psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:I267	R:R:V110	3.07	No	No	0	4	3
2	R:R:K376	R:R:V110	3.04	No	No	0	2	3
3	R:R:L111	R:R:P113	3.28	No	No	0	4	2
4	R:R:K373	R:R:N112	8.39	No	No	0	3	6
5	R:R:K376	R:R:N112	8.39	No	No	0	2	6
6	R:R:P113	R:R:Q116	6.32	No	Yes	0	2	4
7	R:R:I119	R:R:Q116	8.23	No	Yes	7	5	4
8	R:R:A380	R:R:Q116	4.55	No	Yes	0	4	4
9	R:R:F381	R:R:Q116	11.71	No	Yes	7	4	4
10	R:R:F381	R:R:I119	2.51	No	No	7	4	5
11	R:R:S123	R:R:V171	1.62	No	No	0	7	7
12	R:R:T125	R:R:T128	3.14	No	No	0	4	5
13	R:R:L126	R:R:L387	4.15	No	No	0	6	7
14	R:R:L126	R:R:T391	2.95	No	Yes	0	6	7
15	R:R:G127	R:R:T130	3.64	No	Yes	0	6	7
16	R:R:F129	R:R:L132	4.87	No	No	0	4	3
17	R:R:E133	R:R:F129	3.5	Yes	No	0	8	4
18	R:R:E133	R:R:T130	2.82	Yes	Yes	8	8	7
19	R:R:S167	R:R:T130	4.8	No	Yes	0	7	7
20	R:R:S390	R:R:T130	1.6	No	Yes	0	9	7
21	R:R:T130	R:R:T391	7.85	Yes	Yes	8	7	7
22	R:R:L135	R:R:V131	2.98	No	No	9	3	6
23	R:R:L164	R:R:V131	4.47	No	No	9	7	6
24	R:R:S167	R:R:V131	3.23	No	No	0	7	6
25	R:R:E133	R:R:N134	3.94	Yes	Yes	0	8	9
26	R:R:E133	R:R:T391	7.06	Yes	Yes	8	8	7
27	R:R:E133	R:R:I395	8.2	Yes	No	0	8	6
28	R:R:L164	R:R:N134	2.75	No	Yes	0	7	9
29	R:R:N134	R:R:P394	4.89	Yes	No	0	9	9
30	R:R:L135	R:R:L164	2.77	No	No	9	3	7
31	R:R:A398	R:R:V137	1.7	No	No	0	7	9
32	R:R:L138	R:R:L142	6.92	No	No	0	7	4
33	R:R:L138	R:R:V161	2.98	No	No	0	7	6
34	R:R:I141	R:R:R148	5.01	No	No	0	7	8
35	R:R:I141	R:R:L404	2.85	No	No	0	7	8
36	R:R:L142	R:R:R148	7.29	No	No	0	4	8
37	R:R:R148	R:R:S144	3.95	No	No	0	8	6
38	R:R:L147	R:R:Y153	2.34	No	Yes	0	9	9
39	R:R:C149	R:R:R230	4.18	No	No	0	7	1
40	R:R:R150	R:R:Y153	11.32	No	Yes	5	5	9
41	R:R:D403	R:R:R150	3.57	No	No	5	6	5
42	R:R:H154	R:R:P151	3.05	No	No	3	3	5
43	R:R:P151	R:R:V228	3.53	No	Yes	3	5	6
44	R:R:A233	R:R:P151	1.87	No	No	3	7	5
45	R:R:S152	R:R:T210	1.6	No	No	0	8	9
46	R:R:D213	R:R:S152	2.94	Yes	No	0	9	8
47	R:R:S401	R:R:Y153	5.09	No	Yes	5	8	9
48	R:R:D403	R:R:Y153	10.34	No	Yes	5	6	9
49	R:R:F155	R:R:H154	2.26	Yes	No	3	8	3
50	R:R:A233	R:R:H154	2.93	No	No	3	7	3
51	R:R:F155	R:R:L209	7.31	Yes	No	0	8	6
52	R:R:D213	R:R:F155	2.39	Yes	Yes	3	9	8
53	R:R:A233	R:R:F155	2.77	No	Yes	3	7	8
54	R:R:I156	R:R:Y397	4.84	No	Yes	0	8	9
55	R:R:A160	R:R:G157	1.95	No	No	0	9	6
56	R:R:S158	R:R:S206	4.89	No	No	0	9	8
57	R:R:F237	R:R:S158	6.61	No	No	10	8	9
58	R:R:S158	R:R:W241	6.18	No	Yes	10	9	9
59	R:R:D163	R:R:L159	5.43	No	Yes	0	9	9
60	R:R:L159	R:R:S203	3	Yes	No	0	9	9
61	R:R:L159	R:R:S206	3	Yes	No	0	9	8
62	R:R:L159	R:R:L207	5.54	Yes	No	1	9	8
63	R:R:L159	R:R:N393	5.49	Yes	Yes	1	9	9
64	R:R:A162	R:R:S203	1.71	No	No	0	8	9
65	R:R:A162	R:R:W241	2.59	No	Yes	0	8	9
66	R:R:D163	R:R:S390	11.78	No	No	0	9	9
67	R:R:D163	R:R:P394	4.83	No	No	0	9	9
68	R:R:I169	R:R:L165	4.28	Yes	No	0	5	6
69	R:R:L165	R:R:S199	6.01	No	No	0	6	7
70	R:R:G166	R:R:S199	3.71	No	No	0	8	7
71	R:R:I169	W:W:?1	7.94	Yes	Yes	0	5	0
72	R:R:F170	R:R:S383	3.96	No	No	0	7	6
73	R:R:I175	R:R:Y172	3.63	No	No	0	5	7
74	R:R:K192	R:R:S173	7.65	No	No	0	6	4
75	R:R:D176	R:R:F177	3.58	No	No	0	3	4
76	R:R:D176	R:R:R182	2.38	No	No	0	3	4
77	R:R:F177	R:R:H181	6.79	No	No	0	4	3
78	R:R:F177	R:R:F189	6.43	No	No	0	4	9
79	R:R:H178	R:R:V179	6.92	No	No	0	4	4
80	R:R:F180	R:R:R182	3.21	No	No	0	4	4
81	R:R:D184	R:R:R182	8.34	No	No	0	2	4
82	R:R:N187	R:R:S185	5.96	No	No	0	1	7
83	R:R:S185	R:R:V188	1.62	No	No	0	7	5
84	R:R:L190	R:R:R186	7.29	No	No	0	5	3
85	R:R:P269	R:R:R186	14.41	No	No	0	3	3
86	R:R:F189	R:R:F268	17.15	No	No	0	9	5
87	R:R:L190	R:R:L252	4.15	No	No	2	5	5
88	R:R:H270	R:R:L190	7.71	Yes	No	2	3	5
89	R:R:F191	W:W:?1	31.63	No	Yes	0	5	0
90	R:R:F268	R:R:L193	6.09	No	No	0	5	4
91	R:R:G194	R:R:G195	2.11	No	No	11	6	4
92	R:R:G194	W:W:?1	4.76	No	Yes	11	6	0
93	R:R:A198	R:R:G195	1.95	No	No	0	5	4
94	R:R:G195	W:W:?1	9.52	No	Yes	11	4	0
95	R:R:F200	R:R:V196	2.62	No	No	0	7	7
96	R:R:T197	R:R:W279	3.64	No	Yes	0	6	6
97	R:R:A198	R:R:I245	1.62	No	No	0	5	4
98	R:R:A198	R:R:A248	1.79	No	No	0	5	7
99	R:R:F200	R:R:W356	3.01	No	Yes	6	7	8
100	R:R:C386	R:R:F200	5.59	No	No	6	7	7
101	R:R:A244	R:R:T201	1.68	No	No	0	8	6
102	R:R:A202	R:R:W241	6.48	No	Yes	0	7	9
103	R:R:A202	R:R:A244	1.79	No	No	0	7	8
104	R:R:T283	R:R:V204	3.17	No	No	0	8	7
105	R:R:L286	R:R:V204	4.47	No	No	0	8	7
106	R:R:V204	R:R:W356	3.68	No	Yes	0	7	8
107	R:R:G205	R:R:L286	1.71	No	No	0	5	8
108	R:R:L207	R:R:N393	5.49	No	Yes	1	8	9
109	R:R:L207	R:R:Y397	3.52	No	Yes	1	8	9
110	R:R:F208	R:R:I212	10.05	Yes	No	0	7	7
111	R:R:F208	R:R:L286	8.53	Yes	No	0	7	8
112	R:R:F208	R:R:F289	5.36	Yes	No	0	7	6
113	R:R:F208	R:R:I290	3.77	Yes	Yes	0	7	8
114	R:R:A236	R:R:L209	3.15	No	No	0	5	6
115	R:R:L209	R:R:M240	4.24	No	No	0	6	6
116	R:R:R214	R:R:T210	2.59	No	No	1	9	9
117	R:R:T210	R:R:Y397	2.5	No	Yes	1	9	9
118	R:R:A211	R:R:I290	3.25	No	Yes	1	8	8
119	R:R:A211	R:R:A293	1.79	No	No	0	8	7
120	R:R:A211	R:R:Y294	4	No	Yes	1	8	9
121	R:R:D213	R:R:Y224	8.05	Yes	Yes	3	9	7
122	R:R:D213	R:R:V228	2.92	Yes	Yes	3	9	6
123	R:R:R214	R:R:Y294	7.2	No	Yes	1	9	9
124	R:R:R214	R:R:Y397	3.09	No	Yes	1	9	9
125	R:R:I216	R:R:Y215	3.63	No	No	0	5	8
126	R:R:H219	R:R:Y215	15.24	No	No	12	6	8
127	R:R:Y215	R:R:Y296	10.92	No	No	12	8	4
128	R:R:I218	R:R:S217	4.64	No	No	0	9	8
129	R:R:S217	R:R:Y224	5.09	No	Yes	0	8	7
130	R:R:I218	R:R:K300	2.91	No	No	0	9	5
131	R:R:H219	R:R:R220	9.03	No	No	0	6	5
132	R:R:H219	R:R:Y296	4.36	No	No	12	6	4
133	R:R:L222	R:R:P221	1.64	No	No	0	7	8
134	R:R:A223	R:R:R226	2.77	No	No	0	5	4
135	R:R:A223	R:R:I227	3.25	No	No	0	5	4
136	R:R:V228	R:R:Y224	3.79	Yes	Yes	3	6	7
137	R:R:P231	R:R:T229	6.99	No	No	0	4	8
138	R:R:F237	R:R:W241	5.01	No	Yes	10	8	9
139	R:R:I243	R:R:M240	2.92	No	No	0	5	6
140	R:R:I247	R:R:Y275	3.63	No	No	0	5	7
141	R:R:F278	R:R:I247	2.51	No	No	0	6	5
142	R:R:A248	W:W:?1	4.38	No	Yes	0	7	0
143	R:R:L252	R:R:V249	2.98	No	No	0	5	5
144	R:R:V249	W:W:?1	2.76	No	Yes	0	5	0
145	R:R:L250	R:R:P251	4.93	No	Yes	0	5	6
146	R:R:H270	R:R:P251	7.63	Yes	Yes	2	3	6
147	R:R:D272	R:R:P251	1.61	Yes	Yes	2	5	6
148	R:R:P251	R:R:Y275	15.3	Yes	No	0	6	7
149	R:R:H270	R:R:L252	2.57	Yes	No	2	3	5
150	R:R:H270	R:R:N256	5.1	Yes	No	2	3	6
151	R:R:D272	R:R:N256	6.73	Yes	No	2	5	6
152	R:R:C257	R:R:C264	7.28	No	No	2	9	9
153	R:R:C257	R:R:I271	3.27	No	Yes	2	9	3
154	R:R:C264	R:R:I271	11.46	No	Yes	2	9	3
155	R:R:D266	R:R:I271	2.8	No	Yes	0	4	3
156	R:R:F268	R:R:I267	13.82	No	No	0	5	4
157	R:R:D272	R:R:H270	2.52	Yes	Yes	2	5	3
158	R:R:E273	R:R:I271	5.47	No	Yes	0	3	3
159	R:R:E273	R:R:L276	3.98	No	No	0	3	5
160	R:R:I280	R:R:L276	2.85	Yes	No	4	5	5
161	R:R:L276	R:R:M363	2.83	No	Yes	4	5	6
162	R:R:F278	R:R:V282	7.87	No	No	0	6	6
163	R:R:I280	R:R:W279	3.52	Yes	Yes	4	5	6
164	R:R:T283	R:R:W279	3.64	No	Yes	0	8	6
165	R:R:M363	R:R:W279	3.49	Yes	Yes	4	6	6
166	R:R:G281	R:R:I280	1.76	No	Yes	0	3	5
167	R:R:I280	R:R:L360	4.28	Yes	No	0	5	7
168	R:R:I280	R:R:M363	4.37	Yes	Yes	4	5	6
169	R:R:G281	R:R:S284	1.86	No	No	0	3	5
170	R:R:F289	R:R:V285	3.93	No	No	0	6	6
171	R:R:L287	R:R:L352	5.54	No	No	0	6	9
172	R:R:L287	R:R:W356	4.56	No	Yes	0	6	8
173	R:R:I290	R:R:Y294	2.42	Yes	Yes	1	8	9
174	R:R:I290	R:R:L352	2.85	Yes	No	0	8	9
175	R:R:L349	R:R:V291	4.47	No	No	0	8	5
176	R:R:I297	R:R:Y294	2.42	No	Yes	1	9	9
177	R:R:L345	R:R:Y294	4.69	Yes	Yes	1	8	9
178	R:R:I348	R:R:Y294	3.63	No	Yes	1	8	9
179	R:R:L349	R:R:Y294	5.86	No	Yes	0	8	9
180	R:R:Y294	R:R:Y397	4.96	Yes	Yes	1	9	9
181	R:R:W299	R:R:Y296	4.82	No	No	0	3	4
182	R:R:I297	R:R:L345	2.85	No	Yes	1	9	8
183	R:R:L298	R:R:L345	11.07	No	Yes	0	6	8
184	R:R:K300	R:R:W299	3.48	No	No	0	5	3
185	R:R:A301	R:R:M337	1.61	No	No	0	8	6
186	R:R:D338	R:R:H302	13.87	No	No	0	7	5
187	R:R:H304	R:R:R307	2.26	No	No	0	7	4
188	R:R:H304	R:R:M308	3.94	No	No	0	7	7
189	R:R:H304	R:R:M337	2.63	No	No	0	7	6
190	R:R:A305	R:R:A335	1.79	No	No	13	5	4
191	R:R:M308	R:R:T313	3.01	No	No	0	7	3
192	R:R:R311	R:R:T313	10.35	No	No	0	5	3
193	R:R:R336	R:R:R340	5.33	No	No	0	4	7
194	R:R:I339	R:R:K343	4.36	No	No	0	5	7
195	R:R:L345	R:R:T344	2.95	Yes	No	0	8	8
196	R:R:R400	R:R:T344	10.35	No	No	0	7	8
197	R:R:I396	R:R:L347	5.71	No	No	0	9	7
198	R:R:L347	R:R:R400	3.64	No	No	0	7	7
199	R:R:I348	R:R:I396	2.94	No	No	0	8	9
200	R:R:I348	R:R:Y397	3.63	No	Yes	1	8	9
201	R:R:V351	R:R:V392	1.6	No	No	0	6	6
202	R:R:C355	R:R:N389	7.87	No	No	0	8	9
203	R:R:L359	R:R:W356	2.28	No	Yes	6	7	8
204	R:R:L360	R:R:W356	4.56	No	Yes	0	7	8
205	R:R:C386	R:R:W356	2.61	No	Yes	6	7	8
206	R:R:N389	R:R:W356	3.39	No	Yes	0	9	8
207	R:R:G357	R:R:P358	4.06	No	No	0	5	9
208	R:R:C382	R:R:P358	1.88	No	No	0	5	9
209	R:R:L385	R:R:P358	1.64	No	No	0	7	9
210	R:R:C386	R:R:L359	6.35	No	No	6	7	7
211	R:R:I362	R:R:I375	2.94	No	Yes	4	4	3
212	R:R:F379	R:R:I362	7.54	No	No	4	4	4
213	R:R:F379	R:R:M363	2.49	No	Yes	4	4	6
214	R:R:K370	R:R:Y365	5.97	No	No	0	1	4
215	R:R:D366	R:R:G369	1.68	No	No	0	4	3
216	R:R:D366	R:R:M371	6.93	No	No	0	4	1
217	R:R:F368	R:R:V367	3.93	No	No	0	5	4
218	R:R:I375	R:R:M371	8.75	Yes	No	0	3	1
219	R:R:K376	R:R:M371	10.08	No	No	0	2	1
220	R:R:L374	R:R:T377	4.42	No	No	0	4	1
221	R:R:L374	R:R:V378	2.98	No	No	0	4	4
222	R:R:F379	R:R:I375	2.51	No	Yes	4	4	3
223	R:R:L385	R:R:M384	4.24	No	No	0	7	5
224	R:R:L388	R:R:T391	4.42	No	Yes	0	5	7
225	R:R:I396	R:R:V392	3.07	No	No	0	9	6
226	R:R:N393	R:R:P394	1.63	Yes	No	0	9	9
227	R:R:N393	R:R:Y397	8.14	Yes	Yes	1	9	9
228	R:R:D403	R:R:S401	4.42	No	No	5	6	8
229	R:R:K402	R:R:R405	3.71	No	No	0	5	8
230	R:R:H406	R:R:K402	7.86	No	No	0	4	5
231	R:R:T125	R:R:V121	1.59	No	No	0	4	4
232	R:R:C382	R:R:L359	1.59	No	No	0	5	7
233	R:R:A160	R:R:L138	1.58	No	No	0	9	7
234	R:R:A407	R:R:L147	1.58	No	No	0	7	9
235	R:R:A342	R:R:L298	1.58	No	No	0	7	6
236	R:R:A301	R:R:L341	1.58	No	No	0	8	8
237	R:R:A398	R:R:L404	1.58	No	No	0	7	8
238	R:R:A160	R:R:N134	1.56	No	Yes	0	9	9
239	R:R:C257	R:R:D272	1.56	No	Yes	2	9	5
240	R:R:I169	R:R:V168	1.54	Yes	No	0	5	4
241	R:R:I227	R:R:V228	1.54	No	Yes	0	4	6
242	R:R:I243	R:R:V246	1.54	No	No	0	5	3
243	R:R:A305	R:R:D338	1.54	No	No	13	5	7
244	R:R:A335	R:R:D338	1.54	No	No	13	4	7
245	R:R:I354	R:R:V350	1.54	No	No	0	5	6
246	R:R:I362	R:R:V378	1.54	No	No	0	4	4
247	R:R:M277	R:R:V367	1.52	No	No	0	4	4
248	R:R:L147	R:R:S146	1.5	No	No	0	9	5
249	R:R:K232	R:R:T229	1.5	No	No	0	5	8
250	R:R:L404	R:R:S401	1.5	No	No	0	8	8
251	R:R:L122	R:R:V121	1.49	No	No	0	5	4
252	R:R:L387	R:R:V171	1.49	No	No	0	7	7
253	R:R:L253	R:R:V249	1.49	No	No	0	5	5
254	R:R:L347	R:R:V350	1.49	No	No	0	7	6
255	R:R:L239	R:R:T242	1.47	No	No	0	3	4
256	R:R:I353	R:R:I354	1.47	No	No	0	6	5
257	R:R:D184	R:R:V188	1.46	No	No	0	2	5
258	R:R:I169	R:R:K192	1.45	Yes	No	0	5	6
259	R:R:P221	R:R:R220	1.44	No	No	0	8	5
260	R:R:P231	R:R:R230	1.44	No	No	0	4	1
261	R:R:I243	R:R:L239	1.43	No	No	0	5	3
262	R:R:I395	R:R:L399	1.43	No	No	0	6	5
263	R:R:Q115	R:R:T377	1.42	No	No	0	2	1
264	R:R:I375	R:R:N372	1.42	Yes	No	0	3	1
265	R:R:G254	R:R:W255	1.41	No	No	0	5	5
266	R:R:L132	R:R:L136	1.38	No	No	0	3	7
267	R:R:L298	R:R:L341	1.38	No	No	0	6	8
268	R:R:F170	R:R:V171	1.31	No	No	0	7	7
269	R:R:F368	R:R:K370	1.24	No	No	0	5	1
270	R:R:I375	R:R:Y365	1.21	Yes	No	0	3	4
271	R:R:K192	R:R:Y172	1.19	No	No	0	6	7
272	R:R:K225	R:R:Y224	1.19	No	Yes	0	4	7
273	R:R:H143	R:R:R145	1.13	No	No	0	5	6

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	R:R:Q116	7.7025	4	7	4
2	R:R:T130	4.142	5	8	7
3	R:R:E133	5.104	5	8	8
4	R:R:N134	3.285	4	0	9
5	R:R:Y153	7.2725	4	5	9
6	R:R:F155	3.6825	4	3	8
7	R:R:L159	4.492	5	1	9
8	R:R:I169	3.8025	4	0	5
9	R:R:F208	6.9275	4	0	7
10	R:R:D213	4.075	4	3	9
11	R:R:Y224	4.53	4	3	7
12	R:R:V228	2.945	4	3	6
13	R:R:W241	5.065	4	10	9
14	R:R:P251	7.3675	4	2	6
15	R:R:H270	5.106	5	2	3
16	R:R:I271	5.75	4	2	3
17	R:R:D272	3.105	4	2	5
18	R:R:W279	3.5725	4	4	6
19	R:R:I280	3.356	5	4	5
20	R:R:I290	3.0725	4	1	8
21	R:R:Y294	4.3975	8	1	9
22	R:R:L345	5.39	4	1	8
23	R:R:W356	3.44143	7	6	8
24	R:R:M363	3.295	4	4	6
25	R:R:I375	3.366	5	4	3
26	R:R:T391	5.57	4	8	7
27	R:R:N393	5.1875	4	1	9
28	R:R:Y397	4.38286	7	1	9
29	W:W:?1	10.165	6	11	0

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:I267	R:R:V110	24.0809	3.07	No	No	0	4	3
2	R:R:K376	R:R:V110	25.8878	3.04	No	No	0	2	3
3	R:R:K376	R:R:M371	31.2586	10.08	No	No	0	2	1
4	R:R:I375	R:R:M371	36.5544	8.75	Yes	No	0	3	1
5	R:R:F379	R:R:I375	48.0578	2.51	No	Yes	4	4	3
6	R:R:F379	R:R:M363	58.5786	2.49	No	Yes	4	4	6
7	R:R:M363	R:R:W279	28.3942	3.49	Yes	Yes	4	6	6
8	R:R:T283	R:R:W279	30.888	3.64	No	Yes	0	8	6
9	R:R:T283	R:R:V204	31.2378	3.17	No	No	0	8	7
10	R:R:L286	R:R:V204	32.7241	4.47	No	No	0	8	7
11	R:R:F208	R:R:L286	32.8074	8.53	Yes	No	0	7	8
12	R:R:F208	R:R:I290	32.9073	3.77	Yes	Yes	0	7	8
13	R:R:I290	R:R:Y294	100	2.42	Yes	Yes	1	8	9
14	R:R:Y294	R:R:Y397	77.3471	4.96	Yes	Yes	1	9	9
15	R:R:N393	R:R:Y397	55.2271	8.14	Yes	Yes	1	9	9
16	R:R:N393	R:R:P394	40.8427	1.63	Yes	No	0	9	9
17	R:R:N134	R:R:P394	37.8783	4.89	Yes	No	0	9	9
18	R:R:E133	R:R:N134	16.5869	3.94	Yes	Yes	0	8	9
19	R:R:I280	R:R:M363	27.9737	4.37	Yes	Yes	4	5	6
20	R:R:I280	R:R:L360	62.9377	4.28	Yes	No	0	5	7
21	R:R:L360	R:R:W356	63.4498	4.56	No	Yes	0	7	8
22	R:R:L287	R:R:W356	67.38	4.56	No	Yes	0	6	8
23	R:R:L287	R:R:L352	67.7464	5.54	No	No	0	6	9
24	R:R:I290	R:R:L352	68.1211	2.85	Yes	No	0	8	9
25	R:R:D163	R:R:S390	11.2619	11.78	No	No	0	9	9
26	R:R:D163	R:R:L159	11.2286	5.43	No	Yes	0	9	9
27	R:R:L159	R:R:N393	17.4862	5.49	Yes	Yes	1	9	9
28	R:R:L159	R:R:L207	15.7708	5.54	Yes	No	1	9	8
29	R:R:L207	R:R:Y397	16.4828	3.52	No	Yes	1	8	9
30	R:R:I141	R:R:L404	11.9947	2.85	No	No	0	7	8
31	R:R:I141	R:R:R148	13.0355	5.01	No	No	0	7	8
32	R:R:L142	R:R:R148	15.0922	7.29	No	No	0	4	8
33	R:R:L138	R:R:L142	16.1081	6.92	No	No	0	7	4
34	R:R:A160	R:R:L138	18.1148	1.58	No	No	0	9	7
35	R:R:A160	R:R:N134	20.0883	1.56	No	Yes	0	9	9
36	R:R:D213	R:R:F155	17.8151	2.39	Yes	Yes	3	9	8
37	R:R:D213	R:R:S152	49.4775	2.94	Yes	No	0	9	8
38	R:R:S152	R:R:T210	51.0762	1.6	No	No	0	8	9
39	R:R:R214	R:R:T210	20.0674	2.59	No	No	1	9	9
40	R:R:R214	R:R:Y294	20.617	7.2	No	Yes	1	9	9
41	R:R:T210	R:R:Y397	32.5742	2.5	No	Yes	1	9	9
42	R:R:F155	R:R:L209	12.6442	7.31	Yes	No	0	8	6
43	R:R:L159	R:R:S206	13.9681	3	Yes	No	0	9	8
44	R:R:S158	R:R:S206	11.9947	4.89	No	No	0	9	8
45	R:R:L159	R:R:S203	11.9739	3	Yes	No	0	9	9
46	R:R:A162	R:R:S203	10.0004	1.71	No	No	0	8	9
47	R:R:I169	W:W:?1	10.6915	7.94	Yes	Yes	0	5	0
48	R:R:V249	W:W:?1	20.8627	2.76	No	Yes	0	5	0
49	R:R:L252	R:R:V249	23.0276	2.98	No	No	0	5	5
50	R:R:H270	R:R:L252	23.8062	2.57	Yes	No	2	3	5
51	R:R:D272	R:R:H270	27.5199	2.52	Yes	Yes	2	5	3
52	R:R:C257	R:R:D272	36.2421	1.56	No	Yes	2	9	5
53	R:R:C257	R:R:I271	37.0623	3.27	No	Yes	2	9	3
54	R:R:E273	R:R:I271	40.0391	5.47	No	Yes	0	3	3
55	R:R:E273	R:R:L276	40.9676	3.98	No	No	0	3	5
56	R:R:D176	R:R:F177	13.227	3.58	No	No	0	3	4
57	R:R:F177	R:R:F189	16.8658	6.43	No	No	0	4	9
58	R:R:F189	R:R:F268	18.6477	17.15	No	No	0	9	5
59	R:R:F268	R:R:I267	22.2657	13.82	No	No	0	5	4
60	R:R:D176	R:R:R182	11.3618	2.38	No	No	0	3	4
61	R:R:A202	R:R:W241	12.0363	6.48	No	Yes	0	7	9
62	R:R:D213	R:R:Y224	22.6987	8.05	Yes	Yes	3	9	7
63	R:R:W299	R:R:Y296	12.6691	4.82	No	No	0	3	4
64	R:R:K300	R:R:W299	14.4469	3.48	No	No	0	5	3
65	R:R:I218	R:R:K300	16.0748	2.91	No	No	0	9	5
66	R:R:I218	R:R:S217	17.84	4.64	No	No	0	9	8
67	R:R:S217	R:R:Y224	19.5928	5.09	No	Yes	0	8	7
68	R:R:L345	R:R:Y294	15.9749	4.69	Yes	Yes	1	8	9
69	R:R:L298	R:R:L345	12.6816	11.07	No	Yes	0	6	8
70	R:R:L298	R:R:L341	10.2127	1.38	No	No	0	6	8
71	R:R:I280	R:R:L276	34.8224	2.85	Yes	No	4	5	5

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:I169	R:R:L165	4.28	0	Yes	No	5	6	1	2
R:R:I169	W:W:?1	7.94	0	Yes	Yes	5	0	1	0
R:R:F191	W:W:?1	31.63	0	No	Yes	5	0	1	0
R:R:G194	R:R:G195	2.11	11	No	No	6	4	1	1
R:R:G194	W:W:?1	4.76	11	No	Yes	6	0	1	0
R:R:A198	R:R:G195	1.95	0	No	No	5	4	2	1
R:R:G195	W:W:?1	9.52	11	No	Yes	4	0	1	0
R:R:A198	R:R:A248	1.79	0	No	No	5	7	2	1
R:R:A248	W:W:?1	4.38	0	No	Yes	7	0	1	0
R:R:L252	R:R:V249	2.98	2	No	No	5	5	2	1
R:R:V249	W:W:?1	2.76	0	No	Yes	5	0	1	0
R:R:I169	R:R:V168	1.54	0	Yes	No	5	4	1	2
R:R:L253	R:R:V249	1.49	0	No	No	5	5	2	1
R:R:I169	R:R:K192	1.45	0	Yes	No	5	6	1	2

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	8IKG_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	1.6
Number of Linked Nodes	247
Number of Links	273
Number of Hubs	29
Number of Links mediated by Hubs	113
Number of Communities	13
Number of Nodes involved in Communities	64
Number of Links involved in Communities	80

Path Summary
Number Of Nodes in MetaPath	72
Number Of Links MetaPath	71
Number of Shortest Paths	40054
Length Of Smallest Path	3
Average Path Length	16.3591
Length of Longest Path	37
Minimum Path Strength	1.315
Average Path Strength	4.28193
Maximum Path Strength	20.575
Minimum Path Correlation	0.7
Average Path Correlation	0.935375
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	3.22581
Average % Of Corr. Nodes	47.8089
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	39.9415
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process
Gene Ontology	Cellular Component
SCOP2	Domain Identifier	• G protein-coupled receptor-like • Transducin (heterotrimeric G protein), gamma chain • Ras-like P-loop GTPases
SCOP2	Family Identifier	• G protein-coupled receptor-like • Transducin (heterotrimeric G protein), gamma chain • Ras-like P-loop GTPases
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	Q2B
PDB Residues	W:W:?1
Environment Details	Open EMBL-EBI Page
Code	Q2B
Name	3-[(1S)-1-(furan-2-yl)-2-nitro-ethyl]-2-phenyl-1H-indole
Synonyms
Identifier
Formula	C20 H16 N2 O3
Molecular Weight	332.353
SMILES
PubChem	703205
Formal Charge	0
Total Atoms	41
Total Chiral Atoms	1
Total Bonds	44
Total Aromatic Bonds	21


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P21554
Sequence	>8IKG_nogp_Chain_R M V L N P S Q Q L A I A V L S L T L G T F T V L E N L L V L C V I L H S R S L R C R P S Y H F I G S L A V A D L L G S V I F V Y S F I D F H V F H R K D S R N V F L F K L G G V T A S F T A S V G S L F L T A I D R Y I S I H R P L A Y K R I V T R P K A V V A F C L M W T I A I V I A V L P L L G W N C C S D I F P H I D E T Y L M F W I G V T S V L L L F I V Y A Y M Y I L W K A H S H A V R M I Q R G T Q K A R M D I R L A K T L V L I L V V L I I C W G P L L A I M V Y D V F G K M N K L I K T V F A F C S M L C L L N S T V N P I I Y A L R S K D L R H A F Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	7FEE	A	Lipid	Cannabinoid	CB₁	Homo sapiens	CP55940	ZCZ011	-	2.7	2022-06-15	doi.org/10.1038/s41589-022-01038-y
	7WV9	A	Lipid	Cannabinoid	CB₁	Homo sapiens	CP55940	ZCZ011	Gi2/β1/γ2	3.36	2022-06-15	doi.org/10.1038/s41589-022-01038-y
	7WV9 (No Gprot)	A	Lipid	Cannabinoid	CB₁	Homo sapiens	CP55940	ZCZ011		3.36	2022-06-15	doi.org/10.1038/s41589-022-01038-y
	8IKH	A	Lipid	Cannabinoid	CB₁	Homo sapiens	-	Q2L	Gi1/β1/γ1	3.3	2024-06-05	doi.org/10.1073/pnas.2321532121
	8IKH (No Gprot)	A	Lipid	Cannabinoid	CB₁	Homo sapiens	-	Q2L		3.3	2024-06-05	doi.org/10.1073/pnas.2321532121
	8IKG	A	Lipid	Cannabinoid	CB₁	Homo sapiens	-	Q2B	Gi1/β1/γ1	3.4	2024-06-05	doi.org/10.1073/pnas.2321532121
	8IKG (No Gprot)	A	Lipid	Cannabinoid	CB₁	Homo sapiens	-	Q2B		3.4	2024-06-05	doi.org/10.1073/pnas.2321532121
	6KQI	A	Lipid	Cannabinoid	CB₁	Homo sapiens	CP55940	Org27569	-	3.25	2019-10-23	doi.org/10.1038/s41589-019-0387-2
	8K8J	A	Lipid	Cannabinoid	CB₁	Homo sapiens	Fenofibrate	-	chim(Gs-CtGq)/β1/γ2	2.88	2024-02-14	doi.org/10.1002/advs.202306311
	8K8J (No Gprot)	A	Lipid	Cannabinoid	CB₁	Homo sapiens	Fenofibrate	-		2.88	2024-02-14	doi.org/10.1002/advs.202306311
	5TGZ	A	Lipid	Cannabinoid	CB₁	Homo sapiens	AM6538	-	-	2.8	2016-11-02	doi.org/10.1016/j.cell.2016.10.004
	6N4B	A	Lipid	Cannabinoid	CB₁	Homo sapiens	MDMB-Fubinaca	-	Gi1/β1/γ2	3	2019-01-30	doi.org/10.1016/j.cell.2018.11.040
	6N4B (No Gprot)	A	Lipid	Cannabinoid	CB₁	Homo sapiens	MDMB-Fubinaca	-		3	2019-01-30	doi.org/10.1016/j.cell.2018.11.040
	6KPG	A	Lipid	Cannabinoid	CB₁	Homo sapiens	AM841	-	Gi1/β1/γ2	3	2020-02-12	doi.org/10.1016/j.cell.2020.01.008
	6KPG (No Gprot)	A	Lipid	Cannabinoid	CB₁	Homo sapiens	AM841	-		3	2020-02-12	doi.org/10.1016/j.cell.2020.01.008
	7V3Z	A	Lipid	Cannabinoid	CB₁	Homo sapiens	CP55940	-	-	3.29	2021-11-24	doi.org/10.1021/jacs.1c06847
	5U09	A	Lipid	Cannabinoid	CB₁	Homo sapiens	Taranabant	-	-	2.6	2016-12-07	doi.org/10.1038/nature20613
	5XR8	A	Lipid	Cannabinoid	CB₁	Homo sapiens	AM841	-	-	2.95	2017-07-12	doi.org/10.1038/nature23272
	5XRA	A	Lipid	Cannabinoid	CB₁	Homo sapiens	AM11542	-	-	2.8	2017-07-12	doi.org/10.1038/nature23272
	8GHV	A	Lipid	Cannabinoid	CB₁	Homo sapiens	AMG315	-	Gi1/β1/γ2	2.8	2023-05-24	doi.org/10.1038/s41467-023-37864-4
	8GHV (No Gprot)	A	Lipid	Cannabinoid	CB₁	Homo sapiens	AMG315	-		2.8	2023-05-24	doi.org/10.1038/s41467-023-37864-4
	9B9Z	A	Lipid	Cannabinoid	CB₁	Homo sapiens	A1AKO	-	-	3.3	2024-11-20	doi.org/10.1038/s41467-024-54206-0
	9BA0	A	Lipid	Cannabinoid	CB₁	Homo sapiens	A1AKN	-	-	3.13	2024-11-20	doi.org/10.1038/s41467-024-54206-0
	9B9Y	A	Lipid	Cannabinoid	CB₁	Homo sapiens	7DY	-	-	3.5	2024-11-20	doi.org/10.1038/s41467-024-54206-0
	9B54	A	Lipid	Cannabinoid	CB₁	Homo sapiens	A1AIW	-	Gi1/β1/γ2	2.86	2025-03-05	doi.org/10.1038/s41586-025-08618-7
	9B54 (No Gprot)	A	Lipid	Cannabinoid	CB₁	Homo sapiens	A1AIW	-		2.86	2025-03-05	doi.org/10.1038/s41586-025-08618-7
	9B65	A	Lipid	Cannabinoid	CB₁	Homo sapiens	KCA	-	Gi1/β1/γ2	3.03	2025-03-05	doi.org/10.1038/s41586-025-08618-7
	9B65 (No Gprot)	A	Lipid	Cannabinoid	CB₁	Homo sapiens	KCA	-		3.03	2025-03-05	doi.org/10.1038/s41586-025-08618-7
	8WRZ	A	Lipid	Cannabinoid	CB₁	Homo sapiens	PubChem 102336704	-	Arrestin2	3.6	2024-02-28	doi.org/10.1093/procel/pwad055
	9ERX	A	Lipid	Cannabinoid	CB₁	Homo sapiens	D9-THC analog	-	Gi1/β1/γ2	2.9	2024-06-26	doi.org/10.21203/rs.3.rs-4277209/v1
	9ERX (No Gprot)	A	Lipid	Cannabinoid	CB₁	Homo sapiens	D9-THC analog	-		2.9	2024-06-26	doi.org/10.21203/rs.3.rs-4277209/v1
	8WU1	A	Lipid	Cannabinoid	CB₁	Homo sapiens	PubChem 119025665	-	Arrestin2	3.2	2024-03-20	doi.org/10.1016/j.cell.2023.11.017
	9DGI	A	Lipid	Cannabinoid	CB₁	Homo sapiens	Z8526711350	-	-	3.35	2025-04-30	doi.org/10.1038/s41467-025-57136-7
	9EGO	A	Lipid	Cannabinoid	CB₁	Homo sapiens	YVF	-	Gi1/β1/γ2	3.2	2025-04-30	doi.org/10.1038/s41467-025-57136-7
	9EGO (No Gprot)	A	Lipid	Cannabinoid	CB₁	Homo sapiens	YVF	-		3.2	2025-04-30	doi.org/10.1038/s41467-025-57136-7
	8GAG	A	Lipid	Cannabinoid	CB₁	Homo sapiens	PubChem 170838490	-	Gi1/β1/γ2	3.3	2024-02-28	To be published
	8GAG (No Gprot)	A	Lipid	Cannabinoid	CB₁	Homo sapiens	PubChem 170838490	-		3.3	2024-02-28	To be published

You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download 8IKG_nogp.zip

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You can also read or download a guide explaining the meaning of all files and numerical data.