psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:E106	R:R:M109	8.12	No	No	1	4	3
2	R:R:E106	R:R:F177	5.83	No	Yes	1	4	4
3	R:R:F108	R:R:F177	3.22	No	Yes	0	5	4
4	R:R:F108	R:R:P269	14.45	No	No	0	5	3
5	R:R:F177	R:R:M109	6.22	Yes	No	1	4	3
6	R:R:H181	R:R:M109	5.25	No	No	0	3	3
7	R:R:K376	R:R:V110	4.55	No	No	0	2	3
8	R:R:T377	R:R:V110	4.76	No	No	0	1	3
9	R:R:L111	R:R:Q116	6.65	No	No	0	4	4
10	R:R:I119	R:R:L111	4.28	No	No	0	5	4
11	R:R:N112	R:R:P113	9.77	No	No	0	6	2
12	R:R:N112	R:R:S114	8.94	No	No	6	6	5
13	R:R:N112	R:R:Q115	9.24	No	No	6	6	2
14	R:R:Q115	R:R:S114	7.22	No	No	6	2	5
15	R:R:F381	R:R:Q115	4.68	No	No	0	4	2
16	R:R:Q116	R:R:V179	12.89	No	No	0	4	4
17	R:R:F174	R:R:I119	3.77	Yes	No	0	5	5
18	R:R:F381	R:R:I119	12.56	No	No	0	4	5
19	R:R:S123	R:R:V171	3.23	No	No	0	7	7
20	R:R:I175	R:R:S123	6.19	No	No	0	5	7
21	R:R:F129	R:R:T125	6.49	No	No	0	4	4
22	R:R:L126	R:R:T391	4.42	No	No	0	6	7
23	R:R:F129	R:R:T128	3.89	No	No	0	4	5
24	R:R:N134	R:R:T130	4.39	Yes	Yes	0	9	7
25	R:R:S167	R:R:T130	6.4	No	Yes	0	7	7
26	R:R:S390	R:R:T130	4.8	No	Yes	0	9	7
27	R:R:T130	R:R:T391	6.28	Yes	No	0	7	7
28	R:R:S167	R:R:V131	3.23	No	No	0	7	6
29	R:R:A160	R:R:N134	4.69	No	Yes	0	9	9
30	R:R:D163	R:R:N134	6.73	Yes	Yes	0	9	9
31	R:R:N134	R:R:P394	8.15	Yes	No	0	9	9
32	R:R:A398	R:R:V137	5.09	No	No	0	7	9
33	R:R:L138	R:R:V161	4.47	No	No	0	7	6
34	R:R:F408	R:R:V140	5.24	No	No	0	7	8
35	R:R:I141	R:R:L404	5.71	No	Yes	0	7	8
36	R:R:L142	R:R:R148	3.64	No	No	0	4	8
37	R:R:S144	R:R:S146	4.89	No	No	0	6	5
38	R:R:L147	R:R:S144	6.01	Yes	No	0	9	6
39	R:R:R145	R:R:R148	9.6	No	No	0	6	8
40	R:R:C149	R:R:R145	8.36	No	No	8	7	6
41	R:R:R145	R:R:R230	5.33	No	Yes	8	6	1
42	R:R:L147	R:R:Y153	8.21	Yes	Yes	3	9	9
43	R:R:L147	R:R:L404	4.15	Yes	Yes	3	9	8
44	R:R:C149	R:R:R230	5.57	No	Yes	8	7	1
45	R:R:R150	R:R:Y153	17.49	No	Yes	3	5	9
46	R:R:D403	R:R:R150	10.72	No	No	3	6	5
47	R:R:D213	R:R:P151	3.22	Yes	No	0	9	5
48	R:R:D213	R:R:S152	7.36	Yes	No	0	9	8
49	R:R:S401	R:R:Y153	5.09	No	Yes	3	8	9
50	R:R:D403	R:R:Y153	9.2	No	Yes	3	6	9
51	R:R:L404	R:R:Y153	7.03	Yes	Yes	3	8	9
52	R:R:H154	R:R:R230	4.51	No	Yes	0	3	1
53	R:R:F155	R:R:L209	12.18	Yes	No	0	8	6
54	R:R:D213	R:R:F155	5.97	Yes	Yes	0	9	8
55	R:R:A233	R:R:F155	4.16	No	Yes	0	7	8
56	R:R:S158	R:R:S206	4.89	No	No	0	9	8
57	R:R:S158	R:R:W241	6.18	No	Yes	0	9	9
58	R:R:D163	R:R:L159	8.14	Yes	Yes	2	9	9
59	R:R:L159	R:R:S206	6.01	Yes	No	0	9	8
60	R:R:L159	R:R:L207	5.54	Yes	No	2	9	8
61	R:R:L159	R:R:N393	4.12	Yes	Yes	2	9	9
62	R:R:D163	R:R:S203	4.42	Yes	No	0	9	9
63	R:R:D163	R:R:S390	8.83	Yes	No	0	9	9
64	R:R:D163	R:R:N393	4.04	Yes	Yes	2	9	9
65	R:R:G166	R:R:S199	3.71	No	No	0	8	7
66	R:R:F170	R:R:F174	12.86	Yes	Yes	1	7	5
67	R:R:F170	R:R:F200	3.22	Yes	Yes	1	7	7
68	R:R:F170	R:R:S383	3.96	Yes	No	1	7	6
69	R:R:F170	R:R:M384	4.98	Yes	No	1	7	5
70	R:R:F170	R:R:L387	6.09	Yes	No	0	7	7
71	L:L:?1	R:R:F170	8.24	Yes	Yes	1	0	7
72	R:R:D176	R:R:Y172	4.6	No	No	9	3	7
73	R:R:K192	R:R:Y172	5.97	No	No	9	6	7
74	L:L:?1	R:R:S173	4.51	Yes	No	0	0	4
75	R:R:F174	R:R:H178	10.18	Yes	No	1	5	4
76	R:R:F174	R:R:S383	5.28	Yes	No	1	5	6
77	R:R:F174	R:R:M384	3.73	Yes	No	1	5	5
78	L:L:?1	R:R:F174	4.58	Yes	Yes	1	0	5
79	R:R:I175	R:R:V179	7.68	No	No	7	5	4
80	R:R:F180	R:R:I175	3.77	No	No	7	4	5
81	R:R:D176	R:R:R182	13.1	No	No	0	3	4
82	R:R:D176	R:R:K192	4.15	No	No	9	3	6
83	R:R:D184	R:R:F177	7.17	No	Yes	0	2	4
84	L:L:?1	R:R:F177	14.64	Yes	Yes	1	0	4
85	L:L:?1	R:R:H178	8.69	Yes	No	1	0	4
86	R:R:F180	R:R:V179	6.55	No	No	7	4	4
87	R:R:D184	R:R:R182	7.15	No	No	0	2	4
88	R:R:D184	R:R:F189	10.75	No	No	0	2	9
89	R:R:N187	R:R:S185	4.47	No	No	0	1	7
90	R:R:N187	R:R:R186	3.62	No	Yes	0	1	3
91	R:R:E258	R:R:R186	3.49	No	Yes	0	1	3
92	R:R:K259	R:R:R186	4.95	No	Yes	0	4	3
93	R:R:H270	R:R:R186	7.9	No	Yes	0	3	3
94	R:R:F189	R:R:P269	7.22	No	No	5	9	3
95	R:R:F189	R:R:H270	5.66	No	No	5	9	3
96	R:R:L190	R:R:P251	3.28	No	No	0	5	6
97	R:R:L190	R:R:N256	5.49	No	No	0	5	6
98	R:R:F268	R:R:L193	7.31	Yes	No	1	5	4
99	L:L:?1	R:R:L193	7.28	Yes	No	1	0	4
100	R:R:G194	R:R:T197	3.64	No	No	0	6	6
101	L:L:?1	R:R:V196	8.95	Yes	No	0	0	7
102	R:R:T197	R:R:W279	4.85	No	Yes	1	6	6
103	L:L:?1	R:R:T197	7.75	Yes	No	1	0	6
104	R:R:F200	R:R:S199	5.28	Yes	No	0	7	7
105	R:R:C386	R:R:F200	5.59	No	Yes	0	7	7
106	L:L:?1	R:R:F200	9.15	Yes	Yes	1	0	7
107	R:R:A244	R:R:T201	3.36	No	No	0	8	6
108	R:R:T201	R:R:W279	10.92	No	Yes	0	6	6
109	R:R:A202	R:R:W241	7.78	No	Yes	0	7	9
110	R:R:V204	R:R:V283	3.21	No	No	0	7	8
111	R:R:L286	R:R:V204	4.47	No	No	0	8	7
112	R:R:V204	R:R:W356	7.36	No	No	0	7	8
113	R:R:G205	R:R:M240	3.49	No	Yes	0	5	6
114	R:R:M240	R:R:S206	4.6	Yes	No	0	6	8
115	R:R:L207	R:R:N393	6.87	No	Yes	2	8	9
116	R:R:L207	R:R:Y397	7.03	No	Yes	2	8	9
117	R:R:F208	R:R:L286	6.09	No	No	0	7	8
118	R:R:F208	R:R:F289	10.72	No	No	0	7	6
119	R:R:F208	R:R:I290	3.77	No	No	0	7	8
120	R:R:L209	R:R:M240	4.24	No	Yes	0	6	6
121	R:R:I210	R:R:R214	6.26	No	No	2	9	9
122	R:R:I210	R:R:Y397	7.25	No	Yes	2	9	9
123	R:R:A211	R:R:I290	4.87	No	No	0	8	8
124	R:R:A211	R:R:Y294	4	No	Yes	0	8	9
125	R:R:D213	R:R:Y224	11.49	Yes	Yes	0	9	7
126	R:R:R214	R:R:Y294	8.23	No	Yes	2	9	9
127	R:R:R214	R:R:Y397	6.17	No	Yes	2	9	9
128	R:R:H219	R:R:Y215	17.42	No	Yes	4	6	8
129	R:R:Y215	R:R:Y292	3.97	Yes	No	4	8	4
130	R:R:Y215	R:R:Y296	9.93	Yes	Yes	4	8	4
131	R:R:I216	R:R:I227	4.42	No	No	0	5	4
132	R:R:S217	R:R:Y224	8.9	No	Yes	0	8	7
133	R:R:I218	R:R:I297	4.42	No	No	0	9	9
134	R:R:I218	R:R:K300	4.36	No	No	0	9	5
135	R:R:H219	R:R:R220	14.67	No	No	0	6	5
136	R:R:H219	R:R:Y296	14.16	No	Yes	4	6	4
137	R:R:A223	R:R:R226	4.15	No	No	0	5	4
138	R:R:A223	R:R:I227	3.25	No	No	0	5	4
139	R:R:K225	R:R:Y224	3.58	No	Yes	0	4	7
140	R:R:V228	R:R:Y224	3.79	No	Yes	0	6	7
141	R:R:P231	R:R:T229	5.25	No	No	0	4	8
142	R:R:K232	R:R:T229	4.5	No	No	0	5	8
143	R:R:F237	R:R:V234	3.93	No	No	0	8	1
144	R:R:C238	R:R:F237	5.59	No	No	0	4	8
145	R:R:M240	R:R:W241	5.82	Yes	Yes	0	6	9
146	R:R:I247	R:R:Y275	4.84	No	Yes	0	5	7
147	R:R:F278	R:R:I247	5.02	No	No	0	6	5
148	R:R:L253	R:R:V249	4.47	No	No	0	5	5
149	R:R:L250	R:R:W255	10.25	No	No	0	5	5
150	R:R:P251	R:R:Y275	12.52	No	Yes	0	6	7
151	R:R:G254	R:R:L260	3.42	No	No	0	5	3
152	R:R:T274	R:R:W255	7.28	No	No	0	5	5
153	R:R:W255	R:R:Y275	15.43	No	Yes	0	5	7
154	R:R:K259	R:R:N256	6.99	No	No	0	4	6
155	R:R:C257	R:R:C264	7.28	No	No	0	9	9
156	R:R:D272	R:R:S262	8.83	No	No	0	5	3
157	R:R:K273	R:R:V263	7.59	No	No	0	3	4
158	R:R:D266	R:R:D366	9.31	No	No	0	4	4
159	R:R:D266	R:R:K376	5.53	No	No	0	4	2
160	R:R:F268	R:R:I267	12.56	Yes	No	0	5	4
161	R:R:D366	R:R:I267	5.6	No	No	0	4	4
162	R:R:F379	R:R:I267	11.3	Yes	No	0	4	4
163	R:R:F268	R:R:I271	10.05	Yes	Yes	0	5	3
164	L:L:?1	R:R:F268	12.81	Yes	Yes	1	0	5
165	R:R:H270	R:R:P269	7.63	No	No	5	3	3
166	R:R:I271	R:R:Y275	8.46	Yes	Yes	0	3	7
167	R:R:I271	R:R:L276	5.71	Yes	No	0	3	5
168	R:R:D272	R:R:T274	11.56	No	No	0	5	5
169	R:R:L276	R:R:V367	4.47	No	No	0	5	4
170	R:R:F278	R:R:V282	5.24	No	No	0	6	6
171	R:R:V283	R:R:W279	9.81	No	Yes	0	8	6
172	L:L:?1	R:R:W279	17.97	Yes	Yes	1	0	6
173	R:R:I280	R:R:L360	5.71	No	No	0	5	7
174	R:R:I280	R:R:M363	7.29	No	Yes	0	5	6
175	R:R:L360	R:R:V283	5.96	No	No	0	7	8
176	R:R:L360	R:R:S284	4.5	No	No	0	7	5
177	R:R:L287	R:R:L352	8.3	No	No	0	6	9
178	R:R:I290	R:R:L352	4.28	No	No	0	8	9
179	R:R:Y292	R:R:Y296	5.96	No	Yes	4	4	4
180	R:R:L345	R:R:Y294	4.69	No	Yes	2	8	9
181	R:R:I348	R:R:Y294	7.25	No	Yes	0	8	9
182	R:R:L349	R:R:Y294	4.69	No	Yes	0	8	9
183	R:R:Y294	R:R:Y397	4.96	Yes	Yes	2	9	9
184	R:R:W299	R:R:Y296	5.79	No	Yes	0	3	4
185	R:R:K300	R:R:Y296	7.17	No	Yes	0	5	4
186	R:R:L298	R:R:L345	11.07	No	No	2	6	8
187	R:R:H304	R:R:K300	5.24	No	No	0	7	5
188	R:R:D338	R:R:V306	4.38	No	No	0	7	5
189	R:R:E340	R:R:R400	3.49	No	No	0	7	7
190	R:R:R400	R:R:T344	15.52	No	No	0	7	8
191	R:R:I396	R:R:L347	4.28	Yes	No	0	9	7
192	R:R:I348	R:R:I396	4.42	No	Yes	0	8	9
193	R:R:V351	R:R:V392	6.41	No	No	0	6	6
194	R:R:I396	R:R:V351	4.61	Yes	No	0	9	6
195	R:R:C355	R:R:N389	12.6	No	No	0	8	9
196	R:R:N389	R:R:W356	6.78	No	No	0	9	8
197	R:R:G357	R:R:P358	4.06	No	No	0	5	9
198	R:R:L385	R:R:P358	3.28	No	No	0	7	9
199	R:R:L359	R:R:M363	4.24	No	Yes	1	7	6
200	R:R:F379	R:R:L359	4.87	Yes	No	1	4	7
201	R:R:C386	R:R:L359	4.76	No	No	0	7	7
202	R:R:F379	R:R:I362	6.28	Yes	No	0	4	4
203	R:R:C382	R:R:I362	3.27	No	No	0	5	4
204	R:R:F379	R:R:M363	4.98	Yes	Yes	1	4	6
205	L:L:?1	R:R:M363	6.37	Yes	Yes	1	0	6
206	R:R:K370	R:R:Y365	11.94	No	No	0	1	4
207	R:R:F368	R:R:V367	3.93	No	No	0	5	4
208	R:R:K370	R:R:M371	8.64	No	No	10	1	1
209	R:R:I375	R:R:K370	7.27	No	No	10	3	1
210	R:R:I375	R:R:M371	4.37	No	No	10	3	1
211	R:R:K373	R:R:K376	5.75	No	No	0	3	2
212	R:R:N389	R:R:N393	12.26	No	Yes	0	9	9
213	R:R:I396	R:R:Y397	6.04	Yes	Yes	0	9	9
214	R:R:L399	R:R:R405	3.64	No	No	0	5	8
215	R:R:L404	R:R:S401	9.01	Yes	No	3	8	8
216	R:R:R405	R:R:R409	5.33	No	No	0	8	5
217	R:R:H406	R:R:R409	6.77	No	No	0	4	5
218	R:R:M411	R:R:S410	4.6	No	No	0	5	3
219	R:R:A407	R:R:L147	3.15	No	Yes	0	7	9
220	R:R:E133	R:R:P394	3.14	No	No	0	8	9
221	R:R:I218	R:R:S217	3.1	No	No	0	9	8
222	R:R:I271	R:R:S265	3.1	Yes	No	0	3	4
223	R:R:A305	R:R:D338	3.09	No	No	0	5	7
224	R:R:I169	R:R:V196	3.07	No	No	0	5	7
225	R:R:K273	R:R:V367	3.04	No	No	0	3	4
226	R:R:L124	R:R:S123	3	No	No	0	3	7
227	R:R:L164	R:R:V131	2.98	No	No	0	7	6
228	R:R:L165	R:R:V161	2.98	No	No	0	6	6
229	R:R:L349	R:R:V291	2.98	No	No	0	8	5
230	R:R:L388	R:R:V392	2.98	No	No	0	5	6
231	R:R:I156	R:R:I210	2.94	No	No	0	8	9
232	R:R:I212	R:R:I216	2.94	No	No	0	7	5
233	R:R:I243	R:R:I247	2.94	No	No	0	5	5
234	R:R:I395	R:R:I396	2.94	No	Yes	0	6	9
235	R:R:A380	R:R:H178	2.93	No	No	0	4	4
236	R:R:P151	R:R:R150	2.88	No	No	0	5	5
237	R:R:P231	R:R:R230	2.88	No	Yes	0	4	1
238	R:R:Q310	R:R:V306	2.87	No	No	0	4	5
239	R:R:I141	R:R:L138	2.85	No	No	0	7	7
240	R:R:I243	R:R:L239	2.85	No	No	0	5	3
241	R:R:I353	R:R:L352	2.85	No	No	0	6	9
242	R:R:K259	R:R:L260	2.82	No	No	0	4	3
243	R:R:H304	R:R:S303	2.79	No	No	0	7	5
244	R:R:H154	R:R:V234	2.77	No	No	0	3	1
245	R:R:A293	R:R:Y215	2.67	No	Yes	0	7	8
246	R:R:R307	R:R:S303	2.64	No	No	0	4	5
247	R:R:F129	R:R:T391	2.59	No	No	0	4	7
248	R:R:A162	R:R:W241	2.59	No	Yes	0	8	9
249	R:R:F289	R:R:I212	2.51	No	No	0	6	7
250	R:R:K183	R:R:R182	2.48	No	No	0	6	4
251	R:R:F155	R:R:F237	2.14	Yes	No	0	8	8
252	R:R:G194	R:R:G195	2.11	No	No	0	6	4
253	R:R:A160	R:R:G157	1.95	No	No	0	9	6
254	R:R:A248	R:R:G194	1.95	No	No	0	7	6
255	R:R:C382	R:R:P358	1.88	No	No	0	5	9
256	R:R:G281	R:R:S284	1.86	No	No	0	3	5
257	R:R:G127	R:R:T130	1.82	No	Yes	0	6	7
258	R:R:A198	R:R:A248	1.79	No	No	0	5	7
259	R:R:P394	R:R:V137	1.77	No	No	0	9	9
260	R:R:C257	R:R:S262	1.72	No	No	0	9	3
261	R:R:G254	R:R:L253	1.71	No	No	0	5	5
262	R:R:A407	R:R:V140	1.7	No	No	0	7	8
263	R:R:C355	R:R:I354	1.64	No	No	0	8	5
264	R:R:S167	R:R:V168	1.62	No	No	0	7	4
265	R:R:S185	R:R:V188	1.62	No	No	0	7	5
266	R:R:A198	R:R:I245	1.62	No	No	0	5	4
267	R:R:V350	R:R:V351	1.6	No	No	0	6	6
268	R:R:T242	R:R:V246	1.59	No	No	0	4	3
269	R:R:T377	R:R:V378	1.59	No	No	0	1	4
270	R:R:A342	R:R:L298	1.58	No	No	0	7	6
271	R:R:A301	R:R:L341	1.58	No	No	0	8	8
272	R:R:I280	R:R:V364	1.54	No	No	0	5	6
273	R:R:L132	R:R:V131	1.49	No	No	0	3	6
274	R:R:L288	R:R:V291	1.49	No	No	0	4	5
275	R:R:I362	R:R:I375	1.47	No	No	0	4	3
276	R:R:P221	R:R:R220	1.44	No	No	0	8	5
277	R:R:I395	R:R:L399	1.43	No	No	0	6	5
278	R:R:L349	R:R:M295	1.41	No	No	0	8	3
279	R:R:K373	R:R:L374	1.41	No	No	0	3	4
280	R:R:A118	R:R:F381	1.39	No	No	0	5	4
281	R:R:L190	R:R:L252	1.38	No	No	0	5	5
282	R:R:L252	R:R:L253	1.38	No	No	0	5	5
283	R:R:L298	R:R:L341	1.38	No	No	2	6	8
284	R:R:L341	R:R:L345	1.38	No	No	2	8	8
285	R:R:D403	R:R:K402	1.38	No	No	0	6	5
286	R:R:H143	R:R:M411	1.31	No	No	0	5	5
287	R:R:F191	R:R:V188	1.31	No	No	0	5	5
288	R:R:E258	R:R:Q261	1.27	No	No	0	1	1
289	R:R:L347	R:R:R400	1.21	No	No	0	7	7

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	R:R:T130	4.738	5	0	7
2	R:R:N134	5.99	4	0	9
3	R:R:L147	5.38	4	3	9
4	R:R:Y153	9.404	5	3	9
5	R:R:F155	6.1125	4	0	8
6	R:R:L159	5.9525	4	2	9
7	R:R:D163	6.432	5	2	9
8	R:R:F170	6.55833	6	1	7
9	R:R:F174	6.73333	6	1	5
10	R:R:F177	7.416	5	1	4
11	R:R:R186	4.99	4	0	3
12	R:R:F200	5.81	4	1	7
13	R:R:D213	7.01	4	0	9
14	R:R:Y215	8.4975	4	4	8
15	R:R:Y224	6.94	4	0	7
16	R:R:R230	4.5725	4	8	1
17	R:R:M240	4.5375	4	0	6
18	R:R:W241	5.5925	4	0	9
19	R:R:F268	10.6825	4	1	5
20	R:R:I271	6.83	4	0	3
21	R:R:Y275	10.3125	4	0	7
22	R:R:W279	10.8875	4	1	6
23	R:R:Y294	5.63667	6	2	9
24	R:R:Y296	8.602	5	4	4
25	R:R:M363	5.72	4	1	6
26	R:R:F379	6.8575	4	1	4
27	R:R:N393	6.8225	4	2	9
28	R:R:I396	4.458	5	0	9
29	R:R:Y397	6.29	5	2	9
30	R:R:L404	6.475	4	3	8
31	L:L:?1	9.245	12	1	0

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:F108	R:R:F177	13.8802	3.22	No	Yes	0	5	4
2	R:R:F108	R:R:P269	12.7656	14.45	No	No	0	5	3
3	L:L:?1	R:R:F177	37.1678	14.64	Yes	Yes	1	0	4
4	L:L:?1	R:R:F268	37.1344	12.81	Yes	Yes	1	0	5
5	R:R:F268	R:R:I267	12.2225	12.56	Yes	No	0	5	4
6	R:R:D366	R:R:I267	10.1696	5.6	No	No	0	4	4
7	L:L:?1	R:R:F174	21.8491	4.58	Yes	Yes	1	0	5
8	R:R:F174	R:R:I119	19.215	3.77	Yes	No	0	5	5
9	R:R:I119	R:R:L111	10.5125	4.28	No	No	0	5	4
10	L:L:?1	R:R:W279	84.6432	17.97	Yes	Yes	1	0	6
11	R:R:V283	R:R:W279	89.5732	9.81	No	Yes	0	8	6
12	R:R:V204	R:R:V283	100	3.21	No	No	0	7	8
13	R:R:V204	R:R:W356	86.7962	7.36	No	No	0	7	8
14	R:R:N389	R:R:W356	86.6724	6.78	No	No	0	9	8
15	R:R:N389	R:R:N393	86.2723	12.26	No	Yes	0	9	9
16	R:R:D163	R:R:N393	31.4137	4.04	Yes	Yes	2	9	9
17	R:R:D163	R:R:N134	26.7267	6.73	Yes	Yes	0	9	9
18	R:R:N134	R:R:T130	17.2907	4.39	Yes	Yes	0	9	7
19	R:R:T130	R:R:T391	14.4041	6.28	Yes	No	0	7	7
20	R:R:D163	R:R:S390	18.2957	8.83	Yes	No	0	9	9
21	R:R:S390	R:R:T130	16.9477	4.8	No	Yes	0	9	7
22	R:R:S167	R:R:T130	14.4041	6.4	No	Yes	0	7	7
23	R:R:L159	R:R:N393	46.8515	4.12	Yes	Yes	2	9	9
24	R:R:L159	R:R:S206	68.8768	6.01	Yes	No	0	9	8
25	R:R:M240	R:R:S206	63.7849	4.6	Yes	No	0	6	8
26	R:R:L209	R:R:M240	59.617	4.24	No	Yes	0	6	6
27	R:R:F155	R:R:L209	58.6977	12.18	Yes	No	0	8	6
28	R:R:D213	R:R:F155	44.8843	5.97	Yes	Yes	0	9	8
29	R:R:D213	R:R:P151	22.0111	3.22	Yes	No	0	9	5
30	R:R:P151	R:R:R150	20.7821	2.88	No	No	0	5	5
31	R:R:R150	R:R:Y153	16.9525	17.49	No	Yes	3	5	9
32	R:R:F155	R:R:F237	16.1094	2.14	Yes	No	0	8	8
33	R:R:F237	R:R:V234	13.4991	3.93	No	No	0	8	1
34	R:R:H154	R:R:V234	12.1797	2.77	No	No	0	3	1
35	R:R:H154	R:R:R230	10.8507	4.51	No	Yes	0	3	1
36	R:R:L207	R:R:N393	19.5437	6.87	No	Yes	2	8	9
37	R:R:D184	R:R:F177	19.4675	7.17	No	Yes	0	2	4
38	R:R:D184	R:R:F189	13.1847	10.75	No	No	0	2	9
39	R:R:H270	R:R:P269	11.7843	7.63	No	No	5	3	3
40	R:R:H270	R:R:R186	21.8491	7.9	No	Yes	0	3	3
41	R:R:F189	R:R:H270	12.0463	5.66	No	No	5	9	3
42	R:R:F268	R:R:I271	29.9038	10.05	Yes	Yes	0	5	3
43	R:R:I271	R:R:Y275	23.0018	8.46	Yes	Yes	0	3	7
44	R:R:L286	R:R:V204	21.1537	4.47	No	No	0	8	7
45	R:R:L207	R:R:Y397	36.8343	7.03	No	Yes	2	8	9
46	R:R:F208	R:R:L286	20.2439	6.09	No	No	0	7	8
47	R:R:F208	R:R:F289	10.3696	10.72	No	No	0	7	6
48	R:R:F208	R:R:I290	15.7759	3.77	No	No	0	7	8
49	R:R:A211	R:R:I290	16.1951	4.87	No	No	0	8	8
50	R:R:A211	R:R:Y294	16.3047	4	No	Yes	0	8	9
51	R:R:D213	R:R:Y224	23.4115	11.49	Yes	Yes	0	9	7
52	R:R:S217	R:R:Y224	19.7961	8.9	No	Yes	0	8	7
53	R:R:I218	R:R:S217	18.5243	3.1	No	No	0	9	8
54	R:R:I218	R:R:K300	16.0713	4.36	No	No	0	9	5
55	R:R:K300	R:R:Y296	10.9603	7.17	No	Yes	0	5	4
56	L:L:?1	R:R:M363	15.0853	6.37	Yes	Yes	1	0	6
57	R:R:I280	R:R:M363	11.2651	7.29	No	Yes	0	5	6
58	R:R:L360	R:R:V283	13.4324	5.96	No	No	0	7	8
59	R:R:I280	R:R:L360	11.5319	5.71	No	No	0	5	7
60	R:R:I396	R:R:Y397	20.9631	6.04	Yes	Yes	0	9	9
61	R:R:F379	R:R:M363	17.9575	4.98	Yes	Yes	1	4	6
62	R:R:F379	R:R:I362	18.0861	6.28	Yes	No	0	4	4
63	R:R:D163	R:R:L159	16.0284	8.14	Yes	Yes	2	9	9
64	R:R:L159	R:R:L207	18.4719	5.54	Yes	No	2	9	8
65	R:R:Y294	R:R:Y397	14.1945	4.96	Yes	Yes	2	9	9

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:E106	R:R:M109	8.12	1	No	No	4	3	2	2
R:R:E106	R:R:F177	5.83	1	No	Yes	4	4	2	1
R:R:F108	R:R:F177	3.22	0	No	Yes	5	4	2	1
R:R:F177	R:R:M109	6.22	1	Yes	No	4	3	1	2
R:R:F174	R:R:I119	3.77	1	Yes	No	5	5	1	2
R:R:F170	R:R:F174	12.86	1	Yes	Yes	7	5	1	1
R:R:F170	R:R:F200	3.22	1	Yes	Yes	7	7	1	1
R:R:F170	R:R:S383	3.96	1	Yes	No	7	6	1	2
R:R:F170	R:R:M384	4.98	1	Yes	No	7	5	1	2
R:R:F170	R:R:L387	6.09	1	Yes	No	7	7	1	2
L:L:?1	R:R:F170	8.24	1	Yes	Yes	0	7	0	1
L:L:?1	R:R:S173	4.51	1	Yes	No	0	4	0	1
R:R:F174	R:R:H178	10.18	1	Yes	No	5	4	1	1
R:R:F174	R:R:S383	5.28	1	Yes	No	5	6	1	2
R:R:F174	R:R:M384	3.73	1	Yes	No	5	5	1	2
L:L:?1	R:R:F174	4.58	1	Yes	Yes	0	5	0	1
R:R:D184	R:R:F177	7.17	0	No	Yes	2	4	2	1
L:L:?1	R:R:F177	14.64	1	Yes	Yes	0	4	0	1
L:L:?1	R:R:H178	8.69	1	Yes	No	0	4	0	1
R:R:F268	R:R:L193	7.31	1	Yes	No	5	4	1	1
L:L:?1	R:R:L193	7.28	1	Yes	No	0	4	0	1
R:R:G194	R:R:T197	3.64	0	No	No	6	6	2	1
L:L:?1	R:R:V196	8.95	1	Yes	No	0	7	0	1
R:R:T197	R:R:W279	4.85	1	No	Yes	6	6	1	1
L:L:?1	R:R:T197	7.75	1	Yes	No	0	6	0	1
R:R:F200	R:R:S199	5.28	1	Yes	No	7	7	1	2
R:R:C386	R:R:F200	5.59	0	No	Yes	7	7	2	1
L:L:?1	R:R:F200	9.15	1	Yes	Yes	0	7	0	1
R:R:T201	R:R:W279	10.92	0	No	Yes	6	6	2	1
R:R:F268	R:R:I267	12.56	1	Yes	No	5	4	1	2
R:R:F379	R:R:I267	11.3	1	Yes	No	4	4	2	2
R:R:F268	R:R:I271	10.05	1	Yes	Yes	5	3	1	2
L:L:?1	R:R:F268	12.81	1	Yes	Yes	0	5	0	1
R:R:V283	R:R:W279	9.81	0	No	Yes	8	6	2	1
L:L:?1	R:R:W279	17.97	1	Yes	Yes	0	6	0	1
R:R:I280	R:R:M363	7.29	0	No	Yes	5	6	2	1
R:R:L359	R:R:M363	4.24	1	No	Yes	7	6	2	1
R:R:F379	R:R:L359	4.87	1	Yes	No	4	7	2	2
R:R:C386	R:R:L359	4.76	0	No	No	7	7	2	2
R:R:F379	R:R:M363	4.98	1	Yes	Yes	4	6	2	1
L:L:?1	R:R:M363	6.37	1	Yes	Yes	0	6	0	1
R:R:I169	R:R:V196	3.07	0	No	No	5	7	2	1
R:R:A380	R:R:H178	2.93	0	No	No	4	4	2	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	8K8J_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	3.21
Number of Linked Nodes	258
Number of Links	289
Number of Hubs	31
Number of Links mediated by Hubs	119
Number of Communities	10
Number of Nodes involved in Communities	56
Number of Links involved in Communities	71

Path Summary
Number Of Nodes in MetaPath	66
Number Of Links MetaPath	65
Number of Shortest Paths	41135
Length Of Smallest Path	3
Average Path Length	13.6722
Length of Longest Path	30
Minimum Path Strength	1.38
Average Path Strength	6.90884
Maximum Path Strength	16.045
Minimum Path Correlation	0.7
Average Path Correlation	0.924968
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	4.54545
Average % Of Corr. Nodes	50.3285
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	39.4865
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function	• binding • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • D1 dopamine receptor binding • protein binding • signaling receptor binding • G protein-coupled receptor binding • dopamine receptor binding • protein-containing complex binding • G-protein beta/gamma-subunit complex binding • pyrophosphatase activity • GTPase activity • G protein activity • ribonucleoside triphosphate phosphatase activity • molecular function regulator activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • enzyme regulator activity • cyclase regulator activity • enzyme activator activity • cyclase activator activity • molecular function activator activity • adenylate cyclase regulator activity • adenylate cyclase activator activity • cation binding • metal ion binding • developmental process • multicellular organismal process • epithelium development • ectodermal placode morphogenesis • epidermis development • molting cycle process • hair cycle • animal organ development • hair follicle placode formation • tissue development • ectodermal placode formation • anatomical structure morphogenesis • skin development • skin epidermis development • hair follicle development
Gene Ontology	Biological Process	• developmental process • multicellular organismal process • epithelium development • ectodermal placode morphogenesis • epidermis development • molting cycle process • hair cycle • animal organ development • hair follicle placode formation • tissue development • ectodermal placode formation • anatomical structure morphogenesis • skin development • skin epidermis development • hair follicle development • molting cycle • anatomical structure development • anatomical structure formation involved in morphogenesis • ectodermal placode development • hair cycle process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of smell • cellular response to stimulus • cellular response to nitrogen compound • response to stimulus • response to endogenous stimulus • response to peptide hormone • cellular response to peptide hormone stimulus • response to oxygen-containing compound • response to nitrogen compound • response to glucagon • cellular response to oxygen-containing compound • cellular response to glucagon stimulus • cellular response to endogenous stimulus • cellular response to chemical stimulus • response to hormone • response to chemical • cellular process • cellular response to hormone stimulus • multicellular organism development • skeletal system development • bone development • system development • regulation of body fluid levels • wound healing • homotypic cell-cell adhesion • cell activation • hemostasis • biological regulation • platelet aggregation • blood coagulation • cell adhesion • cell-cell adhesion • response to stress • coagulation • regulation of biological quality • response to wounding • platelet activation • response to fluid shear stress • vascular endothelial cell response to laminar fluid shear stress • response to laminar fluid shear stress • cellular response to stress • cellular response to laminar fluid shear stress • vascular endothelial cell response to fluid shear stress • cellular response to fluid shear stress • cognition • developmental growth • growth • response to ketone • response to prostaglandin • response to lipid • response to alcohol • cellular response to prostaglandin stimulus • cellular response to prostaglandin E stimulus • cellular response to alcohol • cellular response to lipid • response to prostaglandin E • cellular response to ketone • regulation of biological process • regulation of cellular process • signaling • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cell communication • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • signal transduction • homeostatic process • positive regulation of biological process • adaptive thermogenesis • positive regulation of metabolic process • multicellular organismal-level homeostasis • regulation of cold-induced thermogenesis • cold-induced thermogenesis • temperature homeostasis • positive regulation of cold-induced thermogenesis • positive regulation of multicellular organismal process • metabolic process • regulation of multicellular organismal process • regulation of metabolic process • positive regulation of cellular process • regulation of localization • establishment of protein localization • nitrogen compound transport • regulation of hormone secretion • regulation of protein localization • regulation of peptide secretion • transport • hormone secretion • protein localization to extracellular region • localization • peptide secretion • regulation of secretion by cell • secretion by cell • amide transport • signal release • intracellular protein localization • regulation of peptide hormone secretion • regulation of signaling • regulation of transport • secretion • regulation of hormone levels • regulation of peptide transport • regulation of establishment of protein localization • establishment of protein localization to extracellular region • export from cell • cell-cell signaling • regulation of protein transport • protein secretion • establishment of localization • regulation of protein secretion • regulation of secretion • peptide transport • protein transport • regulation of insulin secretion • peptide hormone secretion • macromolecule localization • hormone transport • regulation of cell communication • insulin secretion • adenylate cyclase-activating adrenergic receptor signaling pathway • adrenergic receptor signaling pathway • cellular localization • establishment of localization in cell • intracellular transport • regulation of defense response • regulation of response to external stimulus • negative regulation of inflammatory response • negative regulation of biological process • inflammatory response to antigenic stimulus • regulation of response to stress • regulation of immune system process • negative regulation of inflammatory response to antigenic stimulus • defense response • immune response • negative regulation of response to stimulus • negative regulation of immune response • regulation of inflammatory response to antigenic stimulus • response to external stimulus • regulation of inflammatory response • regulation of response to stimulus • negative regulation of immune system process • immune system process • negative regulation of response to external stimulus • negative regulation of defense response • regulation of immune response • inflammatory response • positive regulation of adenylate cyclase activity • positive regulation of molecular function • regulation of molecular function • positive regulation of cyclase activity • activation of adenylate cyclase activity • regulation of adenylate cyclase activity • regulation of catalytic activity • positive regulation of catalytic activity • positive regulation of lyase activity • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • cellular response to monoamine stimulus • renal system process • chemical homeostasis • multicellular organismal-level water homeostasis • multicellular organismal-level chemical homeostasis • renal water homeostasis • cellular anatomical structure • membrane • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cell periphery • cytoplasmic side of plasma membrane • GTPase complex
Gene Ontology	Cellular Component	• cellular anatomical structure • membrane • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cell periphery • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • membrane-bounded organelle • extracellular vesicle • extracellular organelle • extracellular region • organelle • extracellular space • vesicle • extracellular membrane-bounded organelle • intracellular anatomical structure • cytoplasm • cytosol • Golgi apparatus subcompartment • Golgi apparatus • organelle subcompartment • trans-Golgi network membrane • intracellular membrane-bounded organelle • endomembrane system • intracellular organelle • trans-Golgi network • organelle membrane • protein binding • binding • enzyme binding • GTPase binding • protein-containing complex binding • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • multicellular organismal process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development • anatomical structure development • sensory system development • system development • cell population proliferation • cellular process • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • signal transduction • cell communication • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • response to oxygen-containing compound • cellular response to oxygen-containing compound • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to chemical stimulus • cellular response to alcohol • response to hormone • response to chemical • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • small GTPase-mediated signal transduction • Ras protein signal transduction • intracellular signal transduction • intracellular signaling cassette • phospholipase C-activating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular response to nitrogen compound • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • response to nitrogen compound • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to monoamine stimulus • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • synaptic signaling • cellular response to acetylcholine • cell-cell signaling • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • non-motile cilium • 9+0 non-motile cilium • cilium • neuron projection • photoreceptor disc membrane • photoreceptor outer segment • plasma membrane bounded cell projection • cell projection • photoreceptor cell cilium • vacuolar membrane • lytic vacuole • vacuole • lytic vacuole membrane • bounding membrane of organelle • lysosomal membrane • lysosome • synapse • cell junction • G-protein beta-subunit binding • fibroblast proliferation • tetrapyrrole binding • heme binding • electron transfer activity • cation binding • transition metal ion binding • iron ion binding • ion binding • metal ion binding • small molecule binding • molecular transducer activity • G protein-coupled receptor activity • transmembrane signaling receptor activity • signaling receptor activity • cannabinoid receptor activity • identical protein binding • electron transport chain • metabolic process • generation of precursor metabolites and energy • cannabinoid signaling pathway • regulation of metabolic process • trans-synaptic signaling • trans-synaptic signaling by endocannabinoid • retrograde trans-synaptic signaling • retrograde trans-synaptic signaling by endocannabinoid • trans-synaptic signaling by lipid • retrograde trans-synaptic signaling by lipid • neuron recognition • cellular developmental process • cell projection organization • cell development • neuron projection development • neuron projection fasciculation • cellular component organization • neurogenesis • neuron differentiation • axonal fasciculation • cell differentiation • cell recognition • cellular component organization or biogenesis • plasma membrane bounded cell projection organization • nervous system development • axon development • generation of neurons • neuron development • inorganic ion homeostasis • intracellular calcium ion homeostasis • homeostatic process • calcium ion homeostasis • regulation of cytosolic calcium ion concentration • regulation of presynaptic cytosolic calcium ion concentration • cellular homeostasis • neuron cellular homeostasis • chemical homeostasis • intracellular monoatomic cation homeostasis • monoatomic ion homeostasis • intracellular chemical homeostasis • monoatomic cation homeostasis • intracellular monoatomic ion homeostasis • glucose homeostasis • carbohydrate homeostasis • G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger • periplasmic space • cytoskeleton • membraneless organelle • intracellular membraneless organelle • actin cytoskeleton • presynapse • presynaptic membrane • plasma membrane region • synaptic membrane • membrane microdomain • membrane raft • growth cone • axon • distal axon • site of polarized growth • GABA-ergic synapse • glutamatergic synapse • mitochondrial membrane • mitochondrion • organelle outer membrane • organelle envelope • mitochondrial envelope • mitochondrial outer membrane • outer membrane
SCOP2	Domain Identifier	• Transducin (heterotrimeric G protein), gamma chain • G protein-coupled receptor-like
SCOP2	Family Identifier	• Transducin (heterotrimeric G protein), gamma chain • G protein-coupled receptor-like
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	J3O
PDB Residues	L:L:?1
Environment Details	Open EMBL-EBI Page
Code	J3O
Name	Fenofibrate
Synonyms	Fenofibrato
Identifier
Formula	C20 H21 Cl O4
Molecular Weight	360.831
SMILES
PubChem	3339
Formal Charge	0
Total Atoms	46
Total Chiral Atoms	0
Total Bonds	47
Total Aromatic Bonds	12


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P21554
Sequence	>8K8J_nogp_Chain_R E C F M V L N P S Q Q L A I A V L S L T L G T F T V L E N L L V L C V I L H S R S L R C R P S Y H F I G S L A V A D L L G S V I F V Y S F I D F H V F H R K D S R N V F L F K L G G V T A S F T A S V G S L F L I A I D R Y I S I H R P L A Y K R I V T R P K A V V A F C L M W T I A I V I A V L P L L G W N C E K L Q S V C S D I F P H I D K T Y L M F W I G V V S V L L L F I V Y A Y M Y I L W K A H S H A V R M I Q D I E L A K T L V L I L V V L I I C W G P L L A I M V Y D V F G K M N K L I K T V F A F C S M L C L L N S T V N P I I Y A L R S K D L R H A F R S M Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	7FEE	A	Lipid	Cannabinoid	CB₁	Homo sapiens	CP55940	ZCZ011	-	2.7	2022-06-15	doi.org/10.1038/s41589-022-01038-y
	7WV9	A	Lipid	Cannabinoid	CB₁	Homo sapiens	CP55940	ZCZ011	Gi2/β1/γ2	3.36	2022-06-15	doi.org/10.1038/s41589-022-01038-y
	7WV9 (No Gprot)	A	Lipid	Cannabinoid	CB₁	Homo sapiens	CP55940	ZCZ011		3.36	2022-06-15	doi.org/10.1038/s41589-022-01038-y
	8IKH	A	Lipid	Cannabinoid	CB₁	Homo sapiens	-	Q2L	Gi1/β1/γ1	3.3	2024-06-05	doi.org/10.1073/pnas.2321532121
	8IKH (No Gprot)	A	Lipid	Cannabinoid	CB₁	Homo sapiens	-	Q2L		3.3	2024-06-05	doi.org/10.1073/pnas.2321532121
	8IKG	A	Lipid	Cannabinoid	CB₁	Homo sapiens	-	Q2B	Gi1/β1/γ1	3.4	2024-06-05	doi.org/10.1073/pnas.2321532121
	8IKG (No Gprot)	A	Lipid	Cannabinoid	CB₁	Homo sapiens	-	Q2B		3.4	2024-06-05	doi.org/10.1073/pnas.2321532121
	6KQI	A	Lipid	Cannabinoid	CB₁	Homo sapiens	CP55940	Org27569	-	3.25	2019-10-23	doi.org/10.1038/s41589-019-0387-2
	8K8J	A	Lipid	Cannabinoid	CB₁	Homo sapiens	Fenofibrate	-	chim(Gs-CtGq)/β1/γ2	2.88	2024-02-14	doi.org/10.1002/advs.202306311
	8K8J (No Gprot)	A	Lipid	Cannabinoid	CB₁	Homo sapiens	Fenofibrate	-		2.88	2024-02-14	doi.org/10.1002/advs.202306311
	5TGZ	A	Lipid	Cannabinoid	CB₁	Homo sapiens	AM6538	-	-	2.8	2016-11-02	doi.org/10.1016/j.cell.2016.10.004
	6N4B	A	Lipid	Cannabinoid	CB₁	Homo sapiens	MDMB-Fubinaca	-	Gi1/β1/γ2	3	2019-01-30	doi.org/10.1016/j.cell.2018.11.040
	6N4B (No Gprot)	A	Lipid	Cannabinoid	CB₁	Homo sapiens	MDMB-Fubinaca	-		3	2019-01-30	doi.org/10.1016/j.cell.2018.11.040
	6KPG	A	Lipid	Cannabinoid	CB₁	Homo sapiens	AM841	-	Gi1/β1/γ2	3	2020-02-12	doi.org/10.1016/j.cell.2020.01.008
	6KPG (No Gprot)	A	Lipid	Cannabinoid	CB₁	Homo sapiens	AM841	-		3	2020-02-12	doi.org/10.1016/j.cell.2020.01.008
	7V3Z	A	Lipid	Cannabinoid	CB₁	Homo sapiens	CP55940	-	-	3.29	2021-11-24	doi.org/10.1021/jacs.1c06847
	5U09	A	Lipid	Cannabinoid	CB₁	Homo sapiens	Taranabant	-	-	2.6	2016-12-07	doi.org/10.1038/nature20613
	5XR8	A	Lipid	Cannabinoid	CB₁	Homo sapiens	AM841	-	-	2.95	2017-07-12	doi.org/10.1038/nature23272
	5XRA	A	Lipid	Cannabinoid	CB₁	Homo sapiens	AM11542	-	-	2.8	2017-07-12	doi.org/10.1038/nature23272
	8GHV	A	Lipid	Cannabinoid	CB₁	Homo sapiens	AMG315	-	Gi1/β1/γ2	2.8	2023-05-24	doi.org/10.1038/s41467-023-37864-4
	8GHV (No Gprot)	A	Lipid	Cannabinoid	CB₁	Homo sapiens	AMG315	-		2.8	2023-05-24	doi.org/10.1038/s41467-023-37864-4
	9B9Z	A	Lipid	Cannabinoid	CB₁	Homo sapiens	A1AKO	-	-	3.3	2024-11-20	doi.org/10.1038/s41467-024-54206-0
	9BA0	A	Lipid	Cannabinoid	CB₁	Homo sapiens	A1AKN	-	-	3.13	2024-11-20	doi.org/10.1038/s41467-024-54206-0
	9B9Y	A	Lipid	Cannabinoid	CB₁	Homo sapiens	7DY	-	-	3.5	2024-11-20	doi.org/10.1038/s41467-024-54206-0
	9B54	A	Lipid	Cannabinoid	CB₁	Homo sapiens	A1AIW	-	Gi1/β1/γ2	2.86	2025-03-05	doi.org/10.1038/s41586-025-08618-7
	9B54 (No Gprot)	A	Lipid	Cannabinoid	CB₁	Homo sapiens	A1AIW	-		2.86	2025-03-05	doi.org/10.1038/s41586-025-08618-7
	9B65	A	Lipid	Cannabinoid	CB₁	Homo sapiens	KCA	-	Gi1/β1/γ2	3.03	2025-03-05	doi.org/10.1038/s41586-025-08618-7
	9B65 (No Gprot)	A	Lipid	Cannabinoid	CB₁	Homo sapiens	KCA	-		3.03	2025-03-05	doi.org/10.1038/s41586-025-08618-7
	8WRZ	A	Lipid	Cannabinoid	CB₁	Homo sapiens	PubChem 102336704	-	Arrestin2	3.6	2024-02-28	doi.org/10.1093/procel/pwad055
	9ERX	A	Lipid	Cannabinoid	CB₁	Homo sapiens	D9-THC analog	-	Gi1/β1/γ2	2.9	2024-06-26	doi.org/10.21203/rs.3.rs-4277209/v1
	9ERX (No Gprot)	A	Lipid	Cannabinoid	CB₁	Homo sapiens	D9-THC analog	-		2.9	2024-06-26	doi.org/10.21203/rs.3.rs-4277209/v1
	8WU1	A	Lipid	Cannabinoid	CB₁	Homo sapiens	PubChem 119025665	-	Arrestin2	3.2	2024-03-20	doi.org/10.1016/j.cell.2023.11.017
	9DGI	A	Lipid	Cannabinoid	CB₁	Homo sapiens	Z8526711350	-	-	3.35	2025-04-30	doi.org/10.1038/s41467-025-57136-7
	9EGO	A	Lipid	Cannabinoid	CB₁	Homo sapiens	YVF	-	Gi1/β1/γ2	3.2	2025-04-30	doi.org/10.1038/s41467-025-57136-7
	9EGO (No Gprot)	A	Lipid	Cannabinoid	CB₁	Homo sapiens	YVF	-		3.2	2025-04-30	doi.org/10.1038/s41467-025-57136-7
	8GAG	A	Lipid	Cannabinoid	CB₁	Homo sapiens	PubChem 170838490	-	Gi1/β1/γ2	3.3	2024-02-28	To be published
	8GAG (No Gprot)	A	Lipid	Cannabinoid	CB₁	Homo sapiens	PubChem 170838490	-		3.3	2024-02-28	To be published

You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download 8K8J_nogp.zip

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