psnGPCR

Press and hold down the left mouse button and move the mouse to rotate.
Press and hold down the central mouse button and move the mouse to translate.
Use the mouse wheel to zoom in or out.
Click on any atom on your molecule and the corresponding residue label will be placed beneath the viewer.

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?501	R:R:F170	7.01	Yes	Yes	1	0	7
2	L:L:?501	R:R:S173	5.4	Yes	No	0	0	4
3	L:L:?501	R:R:F174	5.26	Yes	Yes	1	0	5
4	L:L:?501	R:R:F177	11.39	Yes	No	1	0	4
5	L:L:?501	R:R:H178	6.48	Yes	Yes	1	0	4
6	L:L:?501	R:R:V196	8.58	Yes	No	1	0	7
7	L:L:?501	R:R:T197	7.43	Yes	No	0	0	6
8	L:L:?501	R:R:F200	6.14	Yes	Yes	1	0	7
9	L:L:?501	R:R:F268	19.28	Yes	No	0	0	5
10	L:L:?501	R:R:I271	5.14	Yes	Yes	1	0	3
11	L:L:?501	R:R:S383	5.4	Yes	No	0	0	6
12	R:R:M109	R:R:V110	3.04	No	No	0	3	3
13	R:R:H178	R:R:L111	3.86	Yes	No	0	4	4
14	R:R:N112	R:R:Q115	5.28	No	No	0	6	2
15	R:R:F381	R:R:Q115	12.88	No	No	0	4	2
16	R:R:Q116	R:R:V179	8.6	No	No	0	4	4
17	R:R:F381	R:R:I119	15.07	No	No	0	4	5
18	R:R:L122	R:R:T125	2.95	No	No	0	5	4
19	R:R:L122	R:R:M384	15.55	No	No	0	5	5
20	R:R:I175	R:R:S123	3.1	No	No	0	5	7
21	R:R:L126	R:R:T125	2.95	No	No	0	6	4
22	R:R:L126	R:R:M384	2.83	No	No	0	6	5
23	R:R:G127	R:R:T130	3.64	No	No	0	6	7
24	R:R:E133	R:R:F129	4.66	No	No	0	8	4
25	R:R:S167	R:R:T130	4.8	No	No	0	7	7
26	R:R:T130	R:R:T391	7.85	No	No	0	7	7
27	R:R:L164	R:R:V131	7.45	No	No	0	7	6
28	R:R:S167	R:R:V131	3.23	No	No	0	7	6
29	R:R:E133	R:R:T391	8.47	No	No	0	8	7
30	R:R:E133	R:R:P394	3.14	No	No	0	8	9
31	R:R:A160	R:R:N134	4.69	No	No	0	9	9
32	R:R:D163	R:R:N134	5.39	Yes	No	0	9	9
33	R:R:F408	R:R:L136	6.09	No	No	0	7	7
34	R:R:L138	R:R:L142	2.77	No	No	0	7	4
35	R:R:L138	R:R:V161	2.98	No	No	0	7	6
36	R:R:C139	R:R:V140	3.42	No	Yes	0	4	8
37	R:R:L404	R:R:V140	2.98	No	Yes	0	8	8
38	R:R:F408	R:R:V140	3.93	No	Yes	0	7	8
39	R:R:I141	R:R:Y153	3.63	No	Yes	0	7	9
40	R:R:H143	R:R:R145	11.28	No	No	0	5	6
41	R:R:H143	R:R:M411	7.88	No	No	0	5	5
42	R:R:R148	R:R:S144	13.18	No	No	0	8	6
43	R:R:R145	R:R:S146	10.54	No	No	0	6	5
44	R:R:A407	R:R:R145	2.77	No	No	0	7	6
45	R:R:L147	R:R:Y153	9.38	No	Yes	4	9	9
46	R:R:D403	R:R:L147	4.07	No	No	0	6	9
47	R:R:L147	R:R:L404	5.54	No	No	4	9	8
48	R:R:H154	R:R:R148	3.39	No	No	0	3	8
49	R:R:R150	R:R:Y153	3.09	No	Yes	0	5	9
50	R:R:D403	R:R:R150	9.53	No	No	0	6	5
51	R:R:P151	R:R:V228	3.53	No	No	0	5	6
52	R:R:D213	R:R:S152	4.42	No	No	0	9	8
53	R:R:I156	R:R:Y153	4.84	No	Yes	0	8	9
54	R:R:S401	R:R:Y153	3.82	No	Yes	0	8	9
55	R:R:L404	R:R:Y153	5.86	No	Yes	4	8	9
56	R:R:F155	R:R:L209	10.96	No	No	0	8	6
57	R:R:A233	R:R:F155	2.77	No	No	0	7	8
58	R:R:S158	R:R:S206	3.26	No	No	0	9	8
59	R:R:F237	R:R:S158	7.93	No	No	0	8	9
60	R:R:S158	R:R:W241	4.94	No	Yes	0	9	9
61	R:R:D163	R:R:L159	5.43	Yes	No	0	9	9
62	R:R:L159	R:R:S206	9.01	No	No	0	9	8
63	R:R:L159	R:R:L207	5.54	No	No	0	9	8
64	R:R:D163	R:R:S390	10.31	Yes	No	0	9	9
65	R:R:D163	R:R:N393	4.04	Yes	No	0	9	9
66	R:R:I169	R:R:L165	7.14	No	No	0	5	6
67	R:R:L165	R:R:S199	3	No	No	0	6	7
68	R:R:G166	R:R:S199	3.71	No	No	0	8	7
69	R:R:G195	R:R:I169	3.53	No	No	0	4	5
70	R:R:F170	R:R:F174	16.08	Yes	Yes	1	7	5
71	R:R:F170	R:R:V196	9.18	Yes	No	1	7	7
72	R:R:F170	R:R:F200	6.43	Yes	Yes	1	7	7
73	R:R:F170	R:R:L387	10.96	Yes	No	0	7	7
74	R:R:K192	R:R:S173	7.65	No	No	0	6	4
75	R:R:F174	R:R:H178	4.53	Yes	Yes	1	5	4
76	R:R:D176	R:R:R182	14.29	No	No	0	3	4
77	R:R:F177	R:R:H178	10.18	No	Yes	1	4	4
78	R:R:F177	R:R:R182	13.9	No	No	0	4	4
79	R:R:F180	R:R:V179	7.87	No	No	0	4	4
80	R:R:D184	R:R:R182	4.76	No	No	0	2	4
81	R:R:K183	R:R:V188	4.55	No	No	0	6	5
82	R:R:D184	R:R:H270	10.08	No	Yes	0	2	3
83	R:R:S185	R:R:V188	6.46	No	No	0	7	5
84	R:R:N256	R:R:R186	8.44	No	No	0	6	3
85	R:R:N187	R:R:V188	4.43	No	No	0	1	5
86	R:R:F189	R:R:L193	8.53	Yes	No	1	9	4
87	R:R:F189	R:R:P269	8.67	Yes	No	1	9	3
88	R:R:F189	R:R:H270	12.44	Yes	Yes	1	9	3
89	R:R:F189	R:R:I271	7.54	Yes	Yes	1	9	3
90	R:R:L190	R:R:P251	9.85	No	No	0	5	6
91	R:R:L190	R:R:L252	12.46	No	No	0	5	5
92	R:R:F191	R:R:L252	3.65	No	No	0	5	5
93	R:R:L193	R:R:T197	2.95	No	No	0	4	6
94	R:R:I271	R:R:L193	5.71	Yes	No	1	3	4
95	R:R:G194	R:R:T197	3.64	No	No	0	6	6
96	R:R:F200	R:R:V196	6.55	Yes	No	1	7	7
97	R:R:C386	R:R:F200	8.38	No	Yes	1	7	7
98	R:R:A202	R:R:W241	7.78	No	Yes	0	7	9
99	R:R:L286	R:R:V204	2.98	No	Yes	0	8	7
100	R:R:L287	R:R:V204	2.98	No	Yes	0	6	7
101	R:R:M240	R:R:S206	3.07	No	No	0	6	8
102	R:R:L207	R:R:Y397	5.86	No	Yes	0	8	9
103	R:R:F208	R:R:L209	3.65	Yes	No	0	7	6
104	R:R:F208	R:R:I212	10.05	Yes	No	5	7	7
105	R:R:F208	R:R:L286	3.65	Yes	No	0	7	8
106	R:R:F208	R:R:F289	10.72	Yes	No	5	7	6
107	R:R:L209	R:R:M240	4.24	No	No	0	6	6
108	R:R:T210	R:R:Y397	4.99	No	Yes	0	9	9
109	R:R:A211	R:R:I290	4.87	No	No	0	8	8
110	R:R:F289	R:R:I212	5.02	No	No	5	6	7
111	R:R:D213	R:R:Y224	10.34	No	No	0	9	7
112	R:R:R214	R:R:Y294	7.2	No	Yes	2	9	9
113	R:R:R214	R:R:Y397	5.14	No	Yes	2	9	9
114	R:R:H219	R:R:Y215	13.07	No	No	6	6	8
115	R:R:A293	R:R:Y215	2.67	No	No	0	7	8
116	R:R:Y215	R:R:Y296	10.92	No	Yes	6	8	4
117	R:R:I216	R:R:Y224	4.84	No	No	0	5	7
118	R:R:I216	R:R:I227	4.42	No	No	0	5	4
119	R:R:I218	R:R:S217	3.1	No	No	0	9	8
120	R:R:S217	R:R:Y224	5.09	No	No	0	8	7
121	R:R:I218	R:R:K300	4.36	No	No	0	9	5
122	R:R:H219	R:R:R220	7.9	No	No	0	6	5
123	R:R:H219	R:R:Y296	4.36	No	Yes	6	6	4
124	R:R:P231	R:R:T229	12.24	No	No	0	4	8
125	R:R:K232	R:R:V235	7.59	No	No	0	5	3
126	R:R:A236	R:R:K232	3.21	No	No	0	5	5
127	R:R:L239	R:R:T242	4.42	No	No	0	3	4
128	R:R:I243	R:R:L239	7.14	No	No	0	5	3
129	R:R:M240	R:R:W241	12.8	No	Yes	0	6	9
130	R:R:I247	R:R:L250	2.85	No	Yes	0	5	5
131	R:R:L252	R:R:V249	5.96	No	No	0	5	5
132	R:R:P251	R:R:W255	2.7	No	Yes	1	6	5
133	R:R:P251	R:R:Y275	5.56	No	Yes	1	6	7
134	R:R:G254	R:R:W255	2.81	No	Yes	0	5	5
135	R:R:D272	R:R:W255	15.63	Yes	Yes	1	5	5
136	R:R:W255	R:R:Y275	5.79	Yes	Yes	1	5	7
137	R:R:H270	R:R:N256	3.83	Yes	No	0	3	6
138	R:R:C257	R:R:C264	7.28	No	No	0	9	9
139	R:R:C264	R:R:E273	6.08	No	No	0	9	3
140	R:R:E273	R:R:S265	2.87	No	No	0	3	4
141	R:R:D266	R:R:K370	8.3	No	No	0	4	1
142	R:R:F268	R:R:I267	17.58	No	Yes	0	5	4
143	R:R:I267	R:R:L276	12.85	Yes	No	3	4	5
144	R:R:I267	R:R:M363	5.83	Yes	Yes	3	4	6
145	R:R:F268	R:R:P269	2.89	No	No	0	5	3
146	R:R:H270	R:R:P269	7.63	Yes	No	1	3	3
147	R:R:I271	R:R:Y275	4.84	Yes	Yes	1	3	7
148	R:R:D272	R:R:T274	10.12	Yes	No	0	5	5
149	R:R:D272	R:R:Y275	3.45	Yes	Yes	1	5	7
150	R:R:I280	R:R:L276	2.85	Yes	No	3	5	5
151	R:R:L276	R:R:M363	2.83	No	Yes	3	5	6
152	R:R:T283	R:R:W279	8.49	No	Yes	0	8	6
153	R:R:W279	R:R:W356	4.69	Yes	Yes	0	6	8
154	R:R:M363	R:R:W279	4.65	Yes	Yes	0	6	6
155	R:R:G281	R:R:I280	3.53	No	Yes	0	3	5
156	R:R:I280	R:R:M363	2.92	Yes	Yes	3	5	6
157	R:R:I280	R:R:V364	7.68	Yes	No	0	5	6
158	R:R:G281	R:R:S284	3.71	No	No	0	3	5
159	R:R:L286	R:R:V282	2.98	No	No	0	8	6
160	R:R:L287	R:R:T283	5.9	No	No	0	6	8
161	R:R:L287	R:R:W356	3.42	No	Yes	0	6	8
162	R:R:A293	R:R:F289	4.16	No	No	0	7	6
163	R:R:I290	R:R:L352	2.85	No	No	0	8	9
164	R:R:A293	R:R:Y292	2.67	No	No	0	7	4
165	R:R:Y292	R:R:Y296	7.94	No	Yes	0	4	4
166	R:R:L345	R:R:Y294	8.21	No	Yes	0	8	9
167	R:R:I348	R:R:Y294	8.46	Yes	Yes	2	8	9
168	R:R:L349	R:R:Y294	7.03	No	Yes	0	8	9
169	R:R:Y294	R:R:Y397	4.96	Yes	Yes	2	9	9
170	R:R:L349	R:R:M295	2.83	No	No	0	8	3
171	R:R:W299	R:R:Y296	2.89	No	Yes	0	3	4
172	R:R:K300	R:R:Y296	14.33	No	Yes	0	5	4
173	R:R:L298	R:R:L345	2.77	No	No	0	6	8
174	R:R:H302	R:R:V306	6.92	No	No	0	5	5
175	R:R:D338	R:R:H302	13.87	Yes	No	0	7	5
176	R:R:H304	R:R:M308	9.19	No	No	0	7	7
177	R:R:H304	R:R:M337	3.94	No	No	0	7	6
178	R:R:M308	R:R:T313	3.01	No	No	0	7	3
179	R:R:A335	R:R:D338	4.63	No	Yes	0	4	7
180	R:R:R336	R:R:R340	9.6	No	No	0	4	7
181	R:R:D338	R:R:I339	8.4	Yes	No	0	7	5
182	R:R:I348	R:R:T344	3.04	Yes	No	0	8	8
183	R:R:R400	R:R:T344	12.94	No	No	0	7	8
184	R:R:I396	R:R:L347	12.85	Yes	No	0	9	7
185	R:R:L347	R:R:R400	3.64	No	No	0	7	7
186	R:R:I348	R:R:I396	2.94	Yes	Yes	0	8	9
187	R:R:I348	R:R:Y397	3.63	Yes	Yes	2	8	9
188	R:R:I354	R:R:V350	3.07	No	No	0	5	6
189	R:R:I396	R:R:V351	3.07	Yes	No	0	9	6
190	R:R:C355	R:R:W356	3.92	No	Yes	0	8	8
191	R:R:C355	R:R:N389	11.02	No	No	0	8	9
192	R:R:L359	R:R:W356	5.69	Yes	Yes	1	7	8
193	R:R:L360	R:R:W356	7.97	No	Yes	0	7	8
194	R:R:C386	R:R:W356	3.92	No	Yes	1	7	8
195	R:R:G357	R:R:P358	4.06	No	No	0	5	9
196	R:R:C382	R:R:P358	3.77	No	No	0	5	9
197	R:R:C382	R:R:L359	4.76	No	Yes	0	5	7
198	R:R:L359	R:R:L385	2.77	Yes	No	0	7	7
199	R:R:C386	R:R:L359	3.17	No	Yes	1	7	7
200	R:R:F379	R:R:I362	6.28	No	No	0	4	4
201	R:R:C382	R:R:I362	3.27	No	No	0	5	4
202	R:R:V367	R:R:Y365	12.62	No	No	0	4	4
203	R:R:M371	R:R:V367	10.65	No	No	0	1	4
204	R:R:G369	R:R:K370	5.23	No	No	0	3	1
205	R:R:I375	R:R:M371	18.95	No	No	0	3	1
206	R:R:K373	R:R:N372	4.2	No	No	0	3	1
207	R:R:F379	R:R:S383	6.61	No	No	0	4	6
208	R:R:L388	R:R:T391	4.42	No	No	0	5	7
209	R:R:L388	R:R:V392	2.98	No	No	0	5	6
210	R:R:N389	R:R:N393	14.98	No	No	0	9	9
211	R:R:I396	R:R:V392	3.07	Yes	No	0	9	6
212	R:R:I395	R:R:L399	4.28	No	No	0	6	5
213	R:R:F174	R:R:S123	2.64	Yes	No	0	5	7
214	R:R:F278	R:R:V282	2.62	No	No	0	6	6
215	R:R:D272	R:R:E273	2.6	Yes	No	0	5	3
216	R:R:A162	R:R:W241	2.59	No	Yes	0	8	9
217	R:R:F381	R:R:T377	2.59	No	No	0	4	1
218	R:R:S152	R:R:Y153	2.54	No	Yes	0	8	9
219	R:R:F174	R:R:I119	2.51	Yes	No	0	5	5
220	R:R:T201	R:R:W279	2.43	No	Yes	0	6	6
221	R:R:I297	R:R:Y294	2.42	No	Yes	0	9	9
222	R:R:K192	R:R:Y172	2.39	No	No	0	6	7
223	R:R:L250	R:R:W255	2.28	Yes	Yes	0	5	5
224	R:R:G194	R:R:G195	2.11	No	No	0	6	4
225	R:R:A160	R:R:G157	1.95	No	No	0	9	6
226	R:R:A198	R:R:G195	1.95	No	No	0	5	4
227	R:R:A233	R:R:P151	1.87	No	No	0	7	5
228	R:R:G127	R:R:V171	1.84	No	No	0	6	7
229	R:R:G205	R:R:V204	1.84	No	Yes	0	5	7
230	R:R:A198	R:R:A248	1.79	No	No	0	5	7
231	R:R:P394	R:R:V137	1.77	No	No	0	9	9
232	R:R:G127	R:R:L126	1.71	No	No	0	6	6
233	R:R:C238	R:R:V234	1.71	No	No	0	4	1
234	R:R:A398	R:R:V137	1.7	No	No	0	7	9
235	R:R:A407	R:R:V140	1.7	No	Yes	0	7	8
236	R:R:A244	R:R:T201	1.68	No	No	0	8	6
237	R:R:N112	R:R:P113	1.63	No	No	0	6	2
238	R:R:A120	R:R:I119	1.62	No	No	0	5	5
239	R:R:S203	R:R:V204	1.62	No	Yes	0	9	7
240	R:R:S284	R:R:V285	1.62	No	No	0	5	6
241	R:R:A301	R:R:M337	1.61	No	No	0	8	6
242	R:R:V346	R:R:V350	1.6	No	No	0	6	6
243	R:R:T377	R:R:V110	1.59	No	No	0	1	3
244	R:R:T125	R:R:V121	1.59	No	No	0	4	4
245	R:R:A380	R:R:L111	1.58	No	No	0	4	4
246	R:R:P113	R:R:Q116	1.58	No	No	0	2	4
247	R:R:A342	R:R:L298	1.58	No	No	0	7	6
248	R:R:A301	R:R:L341	1.58	No	No	0	8	8
249	R:R:A305	R:R:D338	1.54	No	Yes	0	5	7
250	R:R:I375	R:R:V378	1.54	No	No	0	3	4
251	R:R:L124	R:R:S123	1.5	No	No	0	3	7
252	R:R:K232	R:R:T229	1.5	No	No	0	5	8
253	R:R:G312	R:R:R311	1.5	No	No	0	4	5
254	R:R:L164	R:R:V168	1.49	No	No	0	7	4
255	R:R:L250	R:R:V246	1.49	Yes	No	0	5	3
256	R:R:L349	R:R:V291	1.49	No	No	0	8	5
257	R:R:I267	R:R:K376	1.45	Yes	No	0	4	2
258	R:R:P221	R:R:R220	1.44	No	No	0	8	5
259	R:R:P231	R:R:R230	1.44	No	No	0	4	1
260	R:R:K376	R:R:M371	1.44	No	No	0	2	1
261	R:R:I141	R:R:L138	1.43	No	No	0	7	7
262	R:R:I290	R:R:L207	1.43	No	No	0	8	8
263	R:R:K373	R:R:L374	1.41	No	No	0	3	4
264	R:R:C238	R:R:F237	1.4	No	No	0	4	8
265	R:R:H406	R:R:S410	1.39	No	No	0	4	3
266	R:R:L135	R:R:L164	1.38	No	No	0	3	7
267	R:R:D184	R:R:K183	1.38	No	No	0	2	6
268	R:R:A223	R:R:R220	1.38	No	No	0	5	5
269	R:R:L250	R:R:L253	1.38	Yes	No	0	5	5
270	R:R:L341	R:R:L345	1.38	No	No	0	8	8
271	R:R:R409	R:R:S410	1.32	No	No	0	5	3
272	R:R:K402	R:R:R405	1.24	No	No	0	5	8
273	R:R:I245	R:R:W241	1.17	No	Yes	0	4	9

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	L:L:?501	7.95545	11	1	0
2	R:R:V140	3.0075	4	0	8
3	R:R:Y153	4.73714	7	4	9
4	R:R:D163	6.2925	4	0	9
5	R:R:F170	9.932	5	1	7
6	R:R:F174	6.204	5	1	5
7	R:R:H178	6.2625	4	1	4
8	R:R:F189	9.295	4	1	9
9	R:R:F200	6.875	4	1	7
10	R:R:V204	2.355	4	0	7
11	R:R:F208	7.0175	4	5	7
12	R:R:W241	5.856	5	0	9
13	R:R:L250	2	4	0	5
14	R:R:W255	5.842	5	1	5
15	R:R:I267	9.4275	4	3	4
16	R:R:H270	8.495	4	1	3
17	R:R:I271	5.8075	4	1	3
18	R:R:D272	7.95	4	1	5
19	R:R:Y275	4.91	4	1	7
20	R:R:W279	5.065	4	0	6
21	R:R:I280	4.245	4	3	5
22	R:R:Y294	6.38	6	2	9
23	R:R:Y296	8.088	5	6	4
24	R:R:D338	7.11	4	0	7
25	R:R:I348	4.5175	4	2	8
26	R:R:W356	4.935	6	1	8
27	R:R:L359	4.0975	4	1	7
28	R:R:M363	4.0575	4	3	6
29	R:R:I396	5.4825	4	0	9
30	R:R:Y397	4.916	5	2	9

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?501	R:R:F174	24.2517	5.26	Yes	Yes	1	0	5
2	R:R:F174	R:R:I119	32.139	2.51	Yes	No	0	5	5
3	R:R:F381	R:R:I119	27.1632	15.07	No	No	0	4	5
4	R:R:F381	R:R:Q115	16.446	12.88	No	No	0	4	2
5	R:R:N112	R:R:Q115	13.7353	5.28	No	No	0	6	2
6	R:R:N112	R:R:P113	11.0121	1.63	No	No	0	6	2
7	L:L:?501	R:R:F200	72.1905	6.14	Yes	Yes	1	0	7
8	R:R:C386	R:R:F200	92.257	8.38	No	Yes	1	7	7
9	R:R:C386	R:R:W356	89.8789	3.92	No	Yes	1	7	8
10	R:R:C355	R:R:W356	50.3733	3.92	No	Yes	0	8	8
11	R:R:C355	R:R:N389	49.5074	11.02	No	No	0	8	9
12	R:R:N389	R:R:N393	48.6917	14.98	No	No	0	9	9
13	R:R:D163	R:R:N393	48.767	4.04	Yes	No	0	9	9
14	R:R:D163	R:R:L159	49.1435	5.43	Yes	No	0	9	9
15	R:R:L159	R:R:L207	70.8414	5.54	No	No	0	9	8
16	R:R:L207	R:R:Y397	66.148	5.86	No	Yes	0	8	9
17	R:R:I348	R:R:Y397	41.8397	3.63	Yes	Yes	2	8	9
18	R:R:I348	R:R:I396	40.1079	2.94	Yes	Yes	0	8	9
19	R:R:I396	R:R:V392	35.885	3.07	Yes	No	0	9	6
20	R:R:L388	R:R:V392	34.3854	2.98	No	No	0	5	6
21	R:R:L388	R:R:T391	32.8732	4.42	No	No	0	5	7
22	R:R:T130	R:R:T391	23.5364	7.85	No	No	0	7	7
23	R:R:G127	R:R:T130	13.7479	3.64	No	No	0	6	7
24	R:R:G127	R:R:L126	10.3846	1.71	No	No	0	6	6
25	R:R:L287	R:R:W356	69.7873	3.42	No	Yes	0	6	8
26	R:R:L287	R:R:V204	80.9688	2.98	No	Yes	0	6	7
27	R:R:L286	R:R:V204	80.7617	2.98	No	Yes	0	8	7
28	R:R:F208	R:R:L286	80.63	3.65	Yes	No	0	7	8
29	R:R:F208	R:R:F289	100	10.72	Yes	No	5	7	6
30	R:R:A293	R:R:F289	99.4165	4.16	No	No	0	7	6
31	R:R:A293	R:R:Y215	52.1993	2.67	No	No	0	7	8
32	R:R:Y215	R:R:Y296	45.0524	10.92	No	Yes	6	8	4
33	R:R:K300	R:R:Y296	85.1478	14.33	No	Yes	0	5	4
34	R:R:I218	R:R:K300	82.3053	4.36	No	No	0	9	5
35	R:R:I218	R:R:S217	79.626	3.1	No	No	0	9	8
36	R:R:S217	R:R:Y224	76.7899	5.09	No	No	0	8	7
37	R:R:D213	R:R:Y224	68.1747	10.34	No	No	0	9	7
38	R:R:D213	R:R:S152	65.2632	4.42	No	No	0	9	8
39	R:R:S152	R:R:Y153	62.6404	2.54	No	Yes	0	8	9
40	R:R:L404	R:R:Y153	30.5766	5.86	No	Yes	4	8	9
41	R:R:L404	R:R:V140	27.9475	2.98	No	Yes	0	8	8
42	R:R:A293	R:R:Y292	46.1881	2.67	No	No	0	7	4
43	R:R:Y292	R:R:Y296	44.9394	7.94	No	Yes	0	4	4
44	R:R:I141	R:R:Y153	12.5682	3.63	No	Yes	0	7	9
45	R:R:A407	R:R:V140	15.6491	1.7	No	Yes	0	7	8
46	R:R:A407	R:R:R145	12.5369	2.77	No	No	0	7	6
47	R:R:F208	R:R:L209	45.9309	3.65	Yes	No	0	7	6
48	R:R:L159	R:R:S206	38.0059	9.01	No	No	0	9	8
49	R:R:L209	R:R:M240	41.068	4.24	No	No	0	6	6
50	L:L:?501	R:R:T197	15.3417	7.43	Yes	No	0	0	6
51	R:R:G194	R:R:T197	14.0993	3.64	No	No	0	6	6
52	R:R:G194	R:R:G195	12.38	2.11	No	No	0	6	4
53	L:L:?501	R:R:F177	10.6043	11.39	Yes	No	1	0	4
54	R:R:F177	R:R:R182	10.1588	13.9	No	No	0	4	4
55	L:L:?501	R:R:F268	14.8209	19.28	Yes	No	0	0	5
56	R:R:F268	R:R:P269	12.6561	2.89	No	No	0	5	3
57	L:L:?501	R:R:I271	33.6136	5.14	Yes	Yes	1	0	3
58	R:R:I271	R:R:Y275	28.7946	4.84	Yes	Yes	1	3	7
59	R:R:F268	R:R:I267	18.0272	17.58	No	Yes	0	5	4
60	R:R:I267	R:R:M363	23.0031	5.83	Yes	Yes	3	4	6
61	R:R:I280	R:R:M363	10.5666	2.92	Yes	Yes	3	5	6
62	R:R:W279	R:R:W356	23.9882	4.69	Yes	Yes	0	6	8
63	R:R:T283	R:R:W279	13.591	8.49	No	Yes	0	8	6
64	R:R:M363	R:R:W279	31.2418	4.65	Yes	Yes	0	6	6
65	R:R:L287	R:R:T283	13.6663	5.9	No	No	0	6	8
66	R:R:Y294	R:R:Y397	20.6438	4.96	Yes	Yes	2	9	9
67	R:R:L345	R:R:Y294	15.2036	8.21	No	Yes	0	8	9
68	R:R:L341	R:R:L345	10.1901	1.38	No	No	0	8	8
69	R:R:I267	R:R:K376	12.5996	1.45	Yes	No	0	4	2
70	R:R:K376	R:R:M371	10.7548	1.44	No	No	0	2	1
71	R:R:F170	R:R:F174	16.8852	16.08	Yes	Yes	1	7	5
72	R:R:F170	R:R:F200	18.5292	6.43	Yes	Yes	1	7	7
73	R:R:M240	R:R:S206	33.5948	3.07	No	No	0	6	8

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:?501	R:R:F170	7.01	1	Yes	Yes	0	7	0	1
L:L:?501	R:R:S173	5.4	1	Yes	No	0	4	0	1
L:L:?501	R:R:F174	5.26	1	Yes	Yes	0	5	0	1
L:L:?501	R:R:F177	11.39	1	Yes	No	0	4	0	1
L:L:?501	R:R:H178	6.48	1	Yes	Yes	0	4	0	1
L:L:?501	R:R:V196	8.58	1	Yes	No	0	7	0	1
L:L:?501	R:R:T197	7.43	1	Yes	No	0	6	0	1
L:L:?501	R:R:F200	6.14	1	Yes	Yes	0	7	0	1
L:L:?501	R:R:F268	19.28	1	Yes	No	0	5	0	1
L:L:?501	R:R:I271	5.14	1	Yes	Yes	0	3	0	1
L:L:?501	R:R:S383	5.4	1	Yes	No	0	6	0	1
R:R:H178	R:R:L111	3.86	1	Yes	No	4	4	1	2
R:R:F170	R:R:F174	16.08	1	Yes	Yes	7	5	1	1
R:R:F170	R:R:V196	9.18	1	Yes	No	7	7	1	1
R:R:F170	R:R:F200	6.43	1	Yes	Yes	7	7	1	1
R:R:F170	R:R:L387	10.96	1	Yes	No	7	7	1	2
R:R:K192	R:R:S173	7.65	0	No	No	6	4	2	1
R:R:F174	R:R:H178	4.53	1	Yes	Yes	5	4	1	1
R:R:F177	R:R:H178	10.18	1	No	Yes	4	4	1	1
R:R:F177	R:R:R182	13.9	1	No	No	4	4	1	2
R:R:F189	R:R:L193	8.53	1	Yes	No	9	4	2	2
R:R:F189	R:R:P269	8.67	1	Yes	No	9	3	2	2
R:R:F189	R:R:I271	7.54	1	Yes	Yes	9	3	2	1
R:R:L193	R:R:T197	2.95	1	No	No	4	6	2	1
R:R:I271	R:R:L193	5.71	1	Yes	No	3	4	1	2
R:R:G194	R:R:T197	3.64	0	No	No	6	6	2	1
R:R:F200	R:R:V196	6.55	1	Yes	No	7	7	1	1
R:R:C386	R:R:F200	8.38	1	No	Yes	7	7	2	1
R:R:F268	R:R:I267	17.58	0	No	Yes	5	4	1	2
R:R:F268	R:R:P269	2.89	0	No	No	5	3	1	2
R:R:I271	R:R:Y275	4.84	1	Yes	Yes	3	7	1	2
R:R:F379	R:R:S383	6.61	0	No	No	4	6	2	1
R:R:F174	R:R:S123	2.64	1	Yes	No	5	7	1	2
R:R:F174	R:R:I119	2.51	1	Yes	No	5	5	1	2

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	6N4B_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	2.67
Number of Linked Nodes	256
Number of Links	273
Number of Hubs	30
Number of Links mediated by Hubs	116
Number of Communities	6
Number of Nodes involved in Communities	36
Number of Links involved in Communities	48

Path Summary
Number Of Nodes in MetaPath	74
Number Of Links MetaPath	73
Number of Shortest Paths	37211
Length Of Smallest Path	3
Average Path Length	15.9515
Length of Longest Path	34
Minimum Path Strength	1.355
Average Path Strength	5.84059
Maximum Path Strength	18.43
Minimum Path Correlation	0.7
Average Path Correlation	0.923823
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	3.84615
Average % Of Corr. Nodes	42.8105
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	34.4543
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process
Gene Ontology	Cellular Component
SCOP2	Domain Identifier	• G protein-coupled receptor-like • Transducin (heterotrimeric G protein), gamma chain • Ras-like P-loop GTPases
SCOP2	Family Identifier	• G protein-coupled receptor-like • Transducin (heterotrimeric G protein), gamma chain • Ras-like P-loop GTPases
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	KCA
PDB Residues	L:L:?501
Environment Details	Open EMBL-EBI Page
Code	KCA
Name	methyl N-{1-[(4-fluorophenyl)methyl]-1H-indazole-3-carbonyl}-3-methyl-L-valinate
Synonyms
Identifier
Formula	C22 H24 F N3 O3
Molecular Weight	397.443
SMILES
PubChem	119025665
Formal Charge	0
Total Atoms	53
Total Chiral Atoms	1
Total Bonds	55
Total Aromatic Bonds	16


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P21554
Sequence	>6N4B_nogp_Chain_R M V L N P S Q Q L A I A V L S L T L G T F T V L E N L L V L C V I L H S R S L R C R P S Y H F I G S L A V A D L L G S V I F V Y S F I D F H V F H R K D S R N V F L F K L G G V T A S F T A S V G S L F L T A I D R Y I S I H R P L A Y K R I V T R P K A V V A F C L M W T I A I V I A V L P L L G W N C C S D I F P H I D E T Y L M F W I G V T S V L L L F I V Y A Y M Y I L W K A H S H A V R M I Q R G T A R M D I R L A K T L V L I L V V L I I C W G P L L A I M V Y D V F G K M N K L I K T V F A F C S M L C L L N S T V N P I I Y A L R S K D L R H A F R S M Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	5TGZ	A	Lipid	Cannabinoid	CB₁	Homo sapiens	AM6538	-	-	2.8	2016-11-02	doi.org/10.1016/j.cell.2016.10.004
	5U09	A	Lipid	Cannabinoid	CB₁	Homo sapiens	Taranabant	-	-	2.6	2016-12-07	doi.org/10.1038/nature20613
	5XR8	A	Lipid	Cannabinoid	CB₁	Homo sapiens	AM12033	-	-	2.95	2017-07-12	doi.org/10.1038/nature23272
	5XRA	A	Lipid	Cannabinoid	CB₁	Homo sapiens	AM11542	-	-	2.8	2017-07-12	doi.org/10.1038/nature23272
	6N4B	A	Lipid	Cannabinoid	CB₁	Homo sapiens	MDMB-Fubinaca	-	Gi1/β1/γ2	3	2019-01-30	doi.org/10.1016/j.cell.2018.11.040
	6N4B (No Gprot)	A	Lipid	Cannabinoid	CB₁	Homo sapiens	MDMB-Fubinaca	-		3	2019-01-30	doi.org/10.1016/j.cell.2018.11.040
	6KQI	A	Lipid	Cannabinoid	CB₁	Homo sapiens	CP55940	Org27569	-	3.25	2019-10-23	doi.org/10.1038/s41589-019-0387-2
	6KPG	A	Lipid	Cannabinoid	CB₁	Homo sapiens	AM841	-	Gi1/β1/γ2	3	2020-02-12	doi.org/10.1016/j.cell.2020.01.008
	6KPG (No Gprot)	A	Lipid	Cannabinoid	CB₁	Homo sapiens	AM841	-		3	2020-02-12	doi.org/10.1016/j.cell.2020.01.008
	7V3Z	A	Lipid	Cannabinoid	CB₁	Homo sapiens	CP55940	-	-	3.29	2021-11-24	doi.org/10.1021/jacs.1c06847
	7FEE	A	Lipid	Cannabinoid	CB₁	Homo sapiens	CP55940	ZCZ011	-	2.7	2022-06-15	doi.org/10.1038/s41589-022-01038-y
	7WV9	A	Lipid	Cannabinoid	CB₁	Homo sapiens	CP55940	ZCZ011	Gi2/β1/γ2	3.36	2022-06-15	doi.org/10.1038/s41589-022-01038-y
	7WV9 (No Gprot)	A	Lipid	Cannabinoid	CB₁	Homo sapiens	CP55940	ZCZ011		3.36	2022-06-15	doi.org/10.1038/s41589-022-01038-y
	8GHV	A	Lipid	Cannabinoid	CB₁	Homo sapiens	AMG315	-	Gi1/β1/γ2	2.8	2023-05-24	doi.org/10.1038/s41467-023-37864-4
	8GHV (No Gprot)	A	Lipid	Cannabinoid	CB₁	Homo sapiens	AMG315	-		2.8	2023-05-24	doi.org/10.1038/s41467-023-37864-4
	8IKG	A	Lipid	Cannabinoid	CB₁	Homo sapiens	-	PubChem 703205	Gi1/β1/γ1	3.4	2024-06-05	doi.org/10.1073/pnas.2321532121
	8IKG (No Gprot)	A	Lipid	Cannabinoid	CB₁	Homo sapiens	-	PubChem 703205		3.4	2024-06-05	doi.org/10.1073/pnas.2321532121
	8IKH	A	Lipid	Cannabinoid	CB₁	Homo sapiens	-	PubChem 171393541	Gi1/β1/γ1	3.3	2024-06-05	doi.org/10.1073/pnas.2321532121
	8IKH (No Gprot)	A	Lipid	Cannabinoid	CB₁	Homo sapiens	-	PubChem 171393541		3.3	2024-06-05	doi.org/10.1073/pnas.2321532121
	9ERX	A	Lipid	Cannabinoid	CB₁	Homo sapiens	D9-THC analog	-	Gi1/β1/γ2	2.9	2024-06-26	doi.org/10.21203/rs.3.rs-4277209/v1
	9ERX (No Gprot)	A	Lipid	Cannabinoid	CB₁	Homo sapiens	D9-THC analog	-		2.9	2024-06-26	doi.org/10.21203/rs.3.rs-4277209/v1
	9B9Z	A	Lipid	Cannabinoid	CB₁	Homo sapiens	MRI-1867	-	-	3.3	2024-11-20	doi.org/10.1038/s41467-024-54206-0
	9BA0	A	Lipid	Cannabinoid	CB₁	Homo sapiens	MRI-1891	-	-	3.13	2024-11-20	doi.org/10.1038/s41467-024-54206-0
	9B54	A	Lipid	Cannabinoid	CB₁	Homo sapiens	VIP36	-	Gi1/β1/γ2	2.86	2025-03-05	doi.org/10.1038/s41586-025-08618-7
	9B54 (No Gprot)	A	Lipid	Cannabinoid	CB₁	Homo sapiens	VIP36	-		2.86	2025-03-05	doi.org/10.1038/s41586-025-08618-7
	9B65	A	Lipid	Cannabinoid	CB₁	Homo sapiens	MDMB-Fubinaca	-	Gi1/β1/γ2	3.03	2025-03-05	doi.org/10.1038/s41586-025-08618-7
	9B65 (No Gprot)	A	Lipid	Cannabinoid	CB₁	Homo sapiens	MDMB-Fubinaca	-		3.03	2025-03-05	doi.org/10.1038/s41586-025-08618-7
	8K8J	A	Lipid	Cannabinoid	CB₁	Homo sapiens	Fenofibrate	-	chim(Gs-CtGq)/β1/γ2	2.88	2024-02-14	doi.org/10.1002/advs.202306311
	8K8J (No Gprot)	A	Lipid	Cannabinoid	CB₁	Homo sapiens	Fenofibrate	-		2.88	2024-02-14	doi.org/10.1002/advs.202306311
	8GAG	A	Lipid	Cannabinoid	CB₁	Homo sapiens	Z8526711350	-	Gi1/β1/γ2	3.3	2024-02-28	To be published
	8GAG (No Gprot)	A	Lipid	Cannabinoid	CB₁	Homo sapiens	Z8526711350	-		3.3	2024-02-28	To be published
	8WRZ	A	Lipid	Cannabinoid	CB₁	Homo sapiens	AM841	-	Arrestin2	3.6	2024-02-28	AM841
	8WU1	A	Lipid	Cannabinoid	CB₁	Homo sapiens	MDMB-Fubinaca	-	Arrestin2	3.2	2024-03-20	doi.org/10.1016/j.cell.2023.11.017
	9B9Y	A	Lipid	Cannabinoid	CB₁	Homo sapiens	Taranabant	-	-	3.5	2024-11-20	doi.org/10.1038/s41467-024-54206-0
	9DGI	A	Lipid	Cannabinoid	CB₁	Homo sapiens	Z8526711350	-	-	3.35	2025-04-30	doi.org/10.1038/s41467-025-57136-7
	9EGO	A	Lipid	Cannabinoid	CB₁	Homo sapiens	Z8526711350	-	Gi1/β1/γ2	3.2	2025-04-30	doi.org/10.1038/s41467-025-57136-7
	9EGO (No Gprot)	A	Lipid	Cannabinoid	CB₁	Homo sapiens	Z8526711350	-		3.2	2025-04-30	doi.org/10.1038/s41467-025-57136-7

You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download 6N4B_nogp.zip

You can click to copy the link of this page to easily come back here later

or use this QR code to link and share this page.

You can also read or download a guide explaining the meaning of all files and numerical data.