psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?501	R:R:F170	7.01	Yes	Yes	1	0	7
2	L:L:?501	R:R:S173	5.4	Yes	No	0	0	4
3	L:L:?501	R:R:F174	5.26	Yes	Yes	1	0	5
4	L:L:?501	R:R:F177	11.39	Yes	No	1	0	4
5	L:L:?501	R:R:H178	6.48	Yes	Yes	1	0	4
6	L:L:?501	R:R:V196	8.58	Yes	No	1	0	7
7	L:L:?501	R:R:T197	7.43	Yes	No	0	0	6
8	L:L:?501	R:R:F200	6.14	Yes	Yes	1	0	7
9	L:L:?501	R:R:F268	19.28	Yes	No	0	0	5
10	L:L:?501	R:R:I271	5.14	Yes	Yes	1	0	3
11	L:L:?501	R:R:S383	5.4	Yes	No	0	0	6
12	R:R:M109	R:R:V110	3.04	No	No	0	3	3
13	R:R:H178	R:R:L111	3.86	Yes	No	0	4	4
14	R:R:N112	R:R:Q115	5.28	No	No	0	6	2
15	R:R:F381	R:R:Q115	12.88	No	No	0	4	2
16	R:R:Q116	R:R:V179	8.6	No	No	0	4	4
17	R:R:F381	R:R:I119	15.07	No	No	0	4	5
18	R:R:L122	R:R:T125	2.95	No	No	0	5	4
19	R:R:L122	R:R:M384	15.55	No	No	0	5	5
20	R:R:I175	R:R:S123	3.1	No	No	0	5	7
21	R:R:L126	R:R:T125	2.95	No	No	0	6	4
22	R:R:L126	R:R:M384	2.83	No	No	0	6	5
23	R:R:G127	R:R:T130	3.64	No	No	0	6	7
24	R:R:E133	R:R:F129	4.66	No	No	0	8	4
25	R:R:S167	R:R:T130	4.8	No	No	0	7	7
26	R:R:T130	R:R:T391	7.85	No	No	0	7	7
27	R:R:L164	R:R:V131	7.45	No	No	0	7	6
28	R:R:S167	R:R:V131	3.23	No	No	0	7	6
29	R:R:E133	R:R:T391	8.47	No	No	0	8	7
30	R:R:E133	R:R:P394	3.14	No	No	0	8	9
31	R:R:A160	R:R:N134	4.69	No	No	0	9	9
32	R:R:D163	R:R:N134	5.39	Yes	No	0	9	9
33	R:R:F408	R:R:L136	6.09	No	No	0	7	7
34	R:R:L138	R:R:L142	2.77	No	No	0	7	4
35	R:R:L138	R:R:V161	2.98	No	No	0	7	6
36	R:R:C139	R:R:V140	3.42	No	Yes	0	4	8
37	R:R:L404	R:R:V140	2.98	No	Yes	0	8	8
38	R:R:F408	R:R:V140	3.93	No	Yes	0	7	8
39	R:R:I141	R:R:Y153	3.63	No	Yes	0	7	9
40	R:R:H143	R:R:R145	11.28	No	No	0	5	6
41	R:R:H143	R:R:M411	7.88	No	No	0	5	5
42	R:R:R148	R:R:S144	13.18	No	No	0	8	6
43	R:R:R145	R:R:S146	10.54	No	No	0	6	5
44	R:R:A407	R:R:R145	2.77	No	No	0	7	6
45	R:R:L147	R:R:Y153	9.38	No	Yes	4	9	9
46	R:R:D403	R:R:L147	4.07	No	No	0	6	9
47	R:R:L147	R:R:L404	5.54	No	No	4	9	8
48	R:R:H154	R:R:R148	3.39	No	No	0	3	8
49	R:R:R150	R:R:Y153	3.09	No	Yes	0	5	9
50	R:R:D403	R:R:R150	9.53	No	No	0	6	5
51	R:R:P151	R:R:V228	3.53	No	No	0	5	6
52	R:R:D213	R:R:S152	4.42	No	No	0	9	8
53	R:R:I156	R:R:Y153	4.84	No	Yes	0	8	9
54	R:R:S401	R:R:Y153	3.82	No	Yes	0	8	9
55	R:R:L404	R:R:Y153	5.86	No	Yes	4	8	9
56	R:R:F155	R:R:L209	10.96	No	No	0	8	6
57	R:R:A233	R:R:F155	2.77	No	No	0	7	8
58	R:R:S158	R:R:S206	3.26	No	No	0	9	8
59	R:R:F237	R:R:S158	7.93	No	No	0	8	9
60	R:R:S158	R:R:W241	4.94	No	Yes	0	9	9
61	R:R:D163	R:R:L159	5.43	Yes	No	0	9	9
62	R:R:L159	R:R:S206	9.01	No	No	0	9	8
63	R:R:L159	R:R:L207	5.54	No	No	0	9	8
64	R:R:D163	R:R:S390	10.31	Yes	No	0	9	9
65	R:R:D163	R:R:N393	4.04	Yes	No	0	9	9
66	R:R:I169	R:R:L165	7.14	No	No	0	5	6
67	R:R:L165	R:R:S199	3	No	No	0	6	7
68	R:R:G166	R:R:S199	3.71	No	No	0	8	7
69	R:R:G195	R:R:I169	3.53	No	No	0	4	5
70	R:R:F170	R:R:F174	16.08	Yes	Yes	1	7	5
71	R:R:F170	R:R:V196	9.18	Yes	No	1	7	7
72	R:R:F170	R:R:F200	6.43	Yes	Yes	1	7	7
73	R:R:F170	R:R:L387	10.96	Yes	No	0	7	7
74	R:R:K192	R:R:S173	7.65	No	No	0	6	4
75	R:R:F174	R:R:H178	4.53	Yes	Yes	1	5	4
76	R:R:D176	R:R:R182	14.29	No	No	0	3	4
77	R:R:F177	R:R:H178	10.18	No	Yes	1	4	4
78	R:R:F177	R:R:R182	13.9	No	No	0	4	4
79	R:R:F180	R:R:V179	7.87	No	No	0	4	4
80	R:R:D184	R:R:R182	4.76	No	No	0	2	4
81	R:R:K183	R:R:V188	4.55	No	No	0	6	5
82	R:R:D184	R:R:H270	10.08	No	Yes	0	2	3
83	R:R:S185	R:R:V188	6.46	No	No	0	7	5
84	R:R:N256	R:R:R186	8.44	No	No	0	6	3
85	R:R:N187	R:R:V188	4.43	No	No	0	1	5
86	R:R:F189	R:R:L193	8.53	Yes	No	1	9	4
87	R:R:F189	R:R:P269	8.67	Yes	No	1	9	3
88	R:R:F189	R:R:H270	12.44	Yes	Yes	1	9	3
89	R:R:F189	R:R:I271	7.54	Yes	Yes	1	9	3
90	R:R:L190	R:R:P251	9.85	No	No	0	5	6
91	R:R:L190	R:R:L252	12.46	No	No	0	5	5
92	R:R:F191	R:R:L252	3.65	No	No	0	5	5
93	R:R:L193	R:R:T197	2.95	No	No	0	4	6
94	R:R:I271	R:R:L193	5.71	Yes	No	1	3	4
95	R:R:G194	R:R:T197	3.64	No	No	0	6	6
96	R:R:F200	R:R:V196	6.55	Yes	No	1	7	7
97	R:R:C386	R:R:F200	8.38	No	Yes	1	7	7
98	R:R:A202	R:R:W241	7.78	No	Yes	0	7	9
99	R:R:L286	R:R:V204	2.98	No	Yes	0	8	7
100	R:R:L287	R:R:V204	2.98	No	Yes	0	6	7
101	R:R:M240	R:R:S206	3.07	No	No	0	6	8
102	R:R:L207	R:R:Y397	5.86	No	Yes	0	8	9
103	R:R:F208	R:R:L209	3.65	Yes	No	0	7	6
104	R:R:F208	R:R:I212	10.05	Yes	No	5	7	7
105	R:R:F208	R:R:L286	3.65	Yes	No	0	7	8
106	R:R:F208	R:R:F289	10.72	Yes	No	5	7	6
107	R:R:L209	R:R:M240	4.24	No	No	0	6	6
108	R:R:T210	R:R:Y397	4.99	No	Yes	0	9	9
109	R:R:A211	R:R:I290	4.87	No	No	0	8	8
110	R:R:F289	R:R:I212	5.02	No	No	5	6	7
111	R:R:D213	R:R:Y224	10.34	No	No	0	9	7
112	R:R:R214	R:R:Y294	7.2	No	Yes	2	9	9
113	R:R:R214	R:R:Y397	5.14	No	Yes	2	9	9
114	R:R:H219	R:R:Y215	13.07	No	No	6	6	8
115	R:R:A293	R:R:Y215	2.67	No	No	0	7	8
116	R:R:Y215	R:R:Y296	10.92	No	Yes	6	8	4
117	R:R:I216	R:R:Y224	4.84	No	No	0	5	7
118	R:R:I216	R:R:I227	4.42	No	No	0	5	4
119	R:R:I218	R:R:S217	3.1	No	No	0	9	8
120	R:R:S217	R:R:Y224	5.09	No	No	0	8	7
121	R:R:I218	R:R:K300	4.36	No	No	0	9	5
122	R:R:H219	R:R:R220	7.9	No	No	0	6	5
123	R:R:H219	R:R:Y296	4.36	No	Yes	6	6	4
124	R:R:P231	R:R:T229	12.24	No	No	0	4	8
125	R:R:K232	R:R:V235	7.59	No	No	0	5	3
126	R:R:A236	R:R:K232	3.21	No	No	0	5	5
127	R:R:L239	R:R:T242	4.42	No	No	0	3	4
128	R:R:I243	R:R:L239	7.14	No	No	0	5	3
129	R:R:M240	R:R:W241	12.8	No	Yes	0	6	9
130	R:R:I247	R:R:L250	2.85	No	Yes	0	5	5
131	R:R:L252	R:R:V249	5.96	No	No	0	5	5
132	R:R:P251	R:R:W255	2.7	No	Yes	1	6	5
133	R:R:P251	R:R:Y275	5.56	No	Yes	1	6	7
134	R:R:G254	R:R:W255	2.81	No	Yes	0	5	5
135	R:R:D272	R:R:W255	15.63	Yes	Yes	1	5	5
136	R:R:W255	R:R:Y275	5.79	Yes	Yes	1	5	7
137	R:R:H270	R:R:N256	3.83	Yes	No	0	3	6
138	R:R:C257	R:R:C264	7.28	No	No	0	9	9
139	R:R:C264	R:R:E273	6.08	No	No	0	9	3
140	R:R:E273	R:R:S265	2.87	No	No	0	3	4
141	R:R:D266	R:R:K370	8.3	No	No	0	4	1
142	R:R:F268	R:R:I267	17.58	No	Yes	0	5	4
143	R:R:I267	R:R:L276	12.85	Yes	No	3	4	5
144	R:R:I267	R:R:M363	5.83	Yes	Yes	3	4	6
145	R:R:F268	R:R:P269	2.89	No	No	0	5	3
146	R:R:H270	R:R:P269	7.63	Yes	No	1	3	3
147	R:R:I271	R:R:Y275	4.84	Yes	Yes	1	3	7
148	R:R:D272	R:R:T274	10.12	Yes	No	0	5	5
149	R:R:D272	R:R:Y275	3.45	Yes	Yes	1	5	7
150	R:R:I280	R:R:L276	2.85	Yes	No	3	5	5
151	R:R:L276	R:R:M363	2.83	No	Yes	3	5	6
152	R:R:T283	R:R:W279	8.49	No	Yes	0	8	6
153	R:R:W279	R:R:W356	4.69	Yes	Yes	0	6	8
154	R:R:M363	R:R:W279	4.65	Yes	Yes	0	6	6
155	R:R:G281	R:R:I280	3.53	No	Yes	0	3	5
156	R:R:I280	R:R:M363	2.92	Yes	Yes	3	5	6
157	R:R:I280	R:R:V364	7.68	Yes	No	0	5	6
158	R:R:G281	R:R:S284	3.71	No	No	0	3	5
159	R:R:L286	R:R:V282	2.98	No	No	0	8	6
160	R:R:L287	R:R:T283	5.9	No	No	0	6	8
161	R:R:L287	R:R:W356	3.42	No	Yes	0	6	8
162	R:R:A293	R:R:F289	4.16	No	No	0	7	6
163	R:R:I290	R:R:L352	2.85	No	No	0	8	9
164	R:R:A293	R:R:Y292	2.67	No	No	0	7	4
165	R:R:Y292	R:R:Y296	7.94	No	Yes	0	4	4
166	R:R:L345	R:R:Y294	8.21	No	Yes	0	8	9
167	R:R:I348	R:R:Y294	8.46	Yes	Yes	2	8	9
168	R:R:L349	R:R:Y294	7.03	No	Yes	0	8	9
169	R:R:Y294	R:R:Y397	4.96	Yes	Yes	2	9	9
170	R:R:L349	R:R:M295	2.83	No	No	0	8	3
171	R:R:W299	R:R:Y296	2.89	No	Yes	0	3	4
172	R:R:K300	R:R:Y296	14.33	No	Yes	0	5	4
173	R:R:L298	R:R:L345	2.77	No	No	0	6	8
174	R:R:H302	R:R:V306	6.92	No	No	0	5	5
175	R:R:D338	R:R:H302	13.87	Yes	No	0	7	5
176	R:R:H304	R:R:M308	9.19	No	No	0	7	7
177	R:R:H304	R:R:M337	3.94	No	No	0	7	6
178	R:R:M308	R:R:T313	3.01	No	No	0	7	3
179	R:R:A335	R:R:D338	4.63	No	Yes	0	4	7
180	R:R:R336	R:R:R340	9.6	No	No	0	4	7
181	R:R:D338	R:R:I339	8.4	Yes	No	0	7	5
182	R:R:I348	R:R:T344	3.04	Yes	No	0	8	8
183	R:R:R400	R:R:T344	12.94	No	No	0	7	8
184	R:R:I396	R:R:L347	12.85	Yes	No	0	9	7
185	R:R:L347	R:R:R400	3.64	No	No	0	7	7
186	R:R:I348	R:R:I396	2.94	Yes	Yes	0	8	9
187	R:R:I348	R:R:Y397	3.63	Yes	Yes	2	8	9
188	R:R:I354	R:R:V350	3.07	No	No	0	5	6
189	R:R:I396	R:R:V351	3.07	Yes	No	0	9	6
190	R:R:C355	R:R:W356	3.92	No	Yes	0	8	8
191	R:R:C355	R:R:N389	11.02	No	No	0	8	9
192	R:R:L359	R:R:W356	5.69	Yes	Yes	1	7	8
193	R:R:L360	R:R:W356	7.97	No	Yes	0	7	8
194	R:R:C386	R:R:W356	3.92	No	Yes	1	7	8
195	R:R:G357	R:R:P358	4.06	No	No	0	5	9
196	R:R:C382	R:R:P358	3.77	No	No	0	5	9
197	R:R:C382	R:R:L359	4.76	No	Yes	0	5	7
198	R:R:L359	R:R:L385	2.77	Yes	No	0	7	7
199	R:R:C386	R:R:L359	3.17	No	Yes	1	7	7
200	R:R:F379	R:R:I362	6.28	No	No	0	4	4
201	R:R:C382	R:R:I362	3.27	No	No	0	5	4
202	R:R:V367	R:R:Y365	12.62	No	No	0	4	4
203	R:R:M371	R:R:V367	10.65	No	No	0	1	4
204	R:R:G369	R:R:K370	5.23	No	No	0	3	1
205	R:R:I375	R:R:M371	18.95	No	No	0	3	1
206	R:R:K373	R:R:N372	4.2	No	No	0	3	1
207	R:R:F379	R:R:S383	6.61	No	No	0	4	6
208	R:R:L388	R:R:T391	4.42	No	No	0	5	7
209	R:R:L388	R:R:V392	2.98	No	No	0	5	6
210	R:R:N389	R:R:N393	14.98	No	No	0	9	9
211	R:R:I396	R:R:V392	3.07	Yes	No	0	9	6
212	R:R:I395	R:R:L399	4.28	No	No	0	6	5
213	R:R:F174	R:R:S123	2.64	Yes	No	0	5	7
214	R:R:F278	R:R:V282	2.62	No	No	0	6	6
215	R:R:D272	R:R:E273	2.6	Yes	No	0	5	3
216	R:R:A162	R:R:W241	2.59	No	Yes	0	8	9
217	R:R:F381	R:R:T377	2.59	No	No	0	4	1
218	R:R:S152	R:R:Y153	2.54	No	Yes	0	8	9
219	R:R:F174	R:R:I119	2.51	Yes	No	0	5	5
220	R:R:T201	R:R:W279	2.43	No	Yes	0	6	6
221	R:R:I297	R:R:Y294	2.42	No	Yes	0	9	9
222	R:R:K192	R:R:Y172	2.39	No	No	0	6	7
223	R:R:L250	R:R:W255	2.28	Yes	Yes	0	5	5
224	R:R:G194	R:R:G195	2.11	No	No	0	6	4
225	R:R:A160	R:R:G157	1.95	No	No	0	9	6
226	R:R:A198	R:R:G195	1.95	No	No	0	5	4
227	R:R:A233	R:R:P151	1.87	No	No	0	7	5
228	R:R:G127	R:R:V171	1.84	No	No	0	6	7
229	R:R:G205	R:R:V204	1.84	No	Yes	0	5	7
230	R:R:A198	R:R:A248	1.79	No	No	0	5	7
231	R:R:P394	R:R:V137	1.77	No	No	0	9	9
232	R:R:G127	R:R:L126	1.71	No	No	0	6	6
233	R:R:C238	R:R:V234	1.71	No	No	0	4	1
234	R:R:A398	R:R:V137	1.7	No	No	0	7	9
235	R:R:A407	R:R:V140	1.7	No	Yes	0	7	8
236	R:R:A244	R:R:T201	1.68	No	No	0	8	6
237	R:R:N112	R:R:P113	1.63	No	No	0	6	2
238	R:R:A120	R:R:I119	1.62	No	No	0	5	5
239	R:R:S203	R:R:V204	1.62	No	Yes	0	9	7
240	R:R:S284	R:R:V285	1.62	No	No	0	5	6
241	R:R:A301	R:R:M337	1.61	No	No	0	8	6
242	R:R:V346	R:R:V350	1.6	No	No	0	6	6
243	R:R:T377	R:R:V110	1.59	No	No	0	1	3
244	R:R:T125	R:R:V121	1.59	No	No	0	4	4
245	R:R:A380	R:R:L111	1.58	No	No	0	4	4
246	R:R:P113	R:R:Q116	1.58	No	No	0	2	4
247	R:R:A342	R:R:L298	1.58	No	No	0	7	6
248	R:R:A301	R:R:L341	1.58	No	No	0	8	8
249	R:R:A305	R:R:D338	1.54	No	Yes	0	5	7
250	R:R:I375	R:R:V378	1.54	No	No	0	3	4
251	R:R:L124	R:R:S123	1.5	No	No	0	3	7
252	R:R:K232	R:R:T229	1.5	No	No	0	5	8
253	R:R:G312	R:R:R311	1.5	No	No	0	4	5
254	R:R:L164	R:R:V168	1.49	No	No	0	7	4
255	R:R:L250	R:R:V246	1.49	Yes	No	0	5	3
256	R:R:L349	R:R:V291	1.49	No	No	0	8	5
257	R:R:I267	R:R:K376	1.45	Yes	No	0	4	2
258	R:R:P221	R:R:R220	1.44	No	No	0	8	5
259	R:R:P231	R:R:R230	1.44	No	No	0	4	1
260	R:R:K376	R:R:M371	1.44	No	No	0	2	1
261	R:R:I141	R:R:L138	1.43	No	No	0	7	7
262	R:R:I290	R:R:L207	1.43	No	No	0	8	8
263	R:R:K373	R:R:L374	1.41	No	No	0	3	4
264	R:R:C238	R:R:F237	1.4	No	No	0	4	8
265	R:R:H406	R:R:S410	1.39	No	No	0	4	3
266	R:R:L135	R:R:L164	1.38	No	No	0	3	7
267	R:R:D184	R:R:K183	1.38	No	No	0	2	6
268	R:R:A223	R:R:R220	1.38	No	No	0	5	5
269	R:R:L250	R:R:L253	1.38	Yes	No	0	5	5
270	R:R:L341	R:R:L345	1.38	No	No	0	8	8
271	R:R:R409	R:R:S410	1.32	No	No	0	5	3
272	R:R:K402	R:R:R405	1.24	No	No	0	5	8
273	R:R:I245	R:R:W241	1.17	No	Yes	0	4	9

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	L:L:?501	7.95545	11	1	0
2	R:R:V140	3.0075	4	0	8
3	R:R:Y153	4.73714	7	4	9
4	R:R:D163	6.2925	4	0	9
5	R:R:F170	9.932	5	1	7
6	R:R:F174	6.204	5	1	5
7	R:R:H178	6.2625	4	1	4
8	R:R:F189	9.295	4	1	9
9	R:R:F200	6.875	4	1	7
10	R:R:V204	2.355	4	0	7
11	R:R:F208	7.0175	4	5	7
12	R:R:W241	5.856	5	0	9
13	R:R:L250	2	4	0	5
14	R:R:W255	5.842	5	1	5
15	R:R:I267	9.4275	4	3	4
16	R:R:H270	8.495	4	1	3
17	R:R:I271	5.8075	4	1	3
18	R:R:D272	7.95	4	1	5
19	R:R:Y275	4.91	4	1	7
20	R:R:W279	5.065	4	0	6
21	R:R:I280	4.245	4	3	5
22	R:R:Y294	6.38	6	2	9
23	R:R:Y296	8.088	5	6	4
24	R:R:D338	7.11	4	0	7
25	R:R:I348	4.5175	4	2	8
26	R:R:W356	4.935	6	1	8
27	R:R:L359	4.0975	4	1	7
28	R:R:M363	4.0575	4	3	6
29	R:R:I396	5.4825	4	0	9
30	R:R:Y397	4.916	5	2	9

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?501	R:R:F174	24.2517	5.26	Yes	Yes	1	0	5
2	R:R:F174	R:R:I119	32.139	2.51	Yes	No	0	5	5
3	R:R:F381	R:R:I119	27.1632	15.07	No	No	0	4	5
4	R:R:F381	R:R:Q115	16.446	12.88	No	No	0	4	2
5	R:R:N112	R:R:Q115	13.7353	5.28	No	No	0	6	2
6	R:R:N112	R:R:P113	11.0121	1.63	No	No	0	6	2
7	L:L:?501	R:R:F200	72.1905	6.14	Yes	Yes	1	0	7
8	R:R:C386	R:R:F200	92.257	8.38	No	Yes	1	7	7
9	R:R:C386	R:R:W356	89.8789	3.92	No	Yes	1	7	8
10	R:R:C355	R:R:W356	50.3733	3.92	No	Yes	0	8	8
11	R:R:C355	R:R:N389	49.5074	11.02	No	No	0	8	9
12	R:R:N389	R:R:N393	48.6917	14.98	No	No	0	9	9
13	R:R:D163	R:R:N393	48.767	4.04	Yes	No	0	9	9
14	R:R:D163	R:R:L159	49.1435	5.43	Yes	No	0	9	9
15	R:R:L159	R:R:L207	70.8414	5.54	No	No	0	9	8
16	R:R:L207	R:R:Y397	66.148	5.86	No	Yes	0	8	9
17	R:R:I348	R:R:Y397	41.8397	3.63	Yes	Yes	2	8	9
18	R:R:I348	R:R:I396	40.1142	2.94	Yes	Yes	0	8	9
19	R:R:I396	R:R:V392	35.885	3.07	Yes	No	0	9	6
20	R:R:L388	R:R:V392	34.3854	2.98	No	No	0	5	6
21	R:R:L388	R:R:T391	32.8732	4.42	No	No	0	5	7
22	R:R:T130	R:R:T391	23.5364	7.85	No	No	0	7	7
23	R:R:G127	R:R:T130	13.7479	3.64	No	No	0	6	7
24	R:R:G127	R:R:L126	10.3846	1.71	No	No	0	6	6
25	R:R:L287	R:R:W356	69.7873	3.42	No	Yes	0	6	8
26	R:R:L287	R:R:V204	80.9688	2.98	No	Yes	0	6	7
27	R:R:L286	R:R:V204	80.7617	2.98	No	Yes	0	8	7
28	R:R:F208	R:R:L286	80.63	3.65	Yes	No	0	7	8
29	R:R:F208	R:R:F289	100	10.72	Yes	No	5	7	6
30	R:R:A293	R:R:F289	99.4165	4.16	No	No	0	7	6
31	R:R:A293	R:R:Y215	52.1993	2.67	No	No	0	7	8
32	R:R:Y215	R:R:Y296	45.0524	10.92	No	Yes	6	8	4
33	R:R:K300	R:R:Y296	85.1478	14.33	No	Yes	0	5	4
34	R:R:I218	R:R:K300	82.3053	4.36	No	No	0	9	5
35	R:R:I218	R:R:S217	79.626	3.1	No	No	0	9	8
36	R:R:S217	R:R:Y224	76.7899	5.09	No	No	0	8	7
37	R:R:D213	R:R:Y224	68.1747	10.34	No	No	0	9	7
38	R:R:D213	R:R:S152	65.2632	4.42	No	No	0	9	8
39	R:R:S152	R:R:Y153	62.6404	2.54	No	Yes	0	8	9
40	R:R:L404	R:R:Y153	30.5766	5.86	No	Yes	4	8	9
41	R:R:L404	R:R:V140	27.9475	2.98	No	Yes	0	8	8
42	R:R:A293	R:R:Y292	46.1881	2.67	No	No	0	7	4
43	R:R:Y292	R:R:Y296	44.9394	7.94	No	Yes	0	4	4
44	R:R:I141	R:R:Y153	12.5682	3.63	No	Yes	0	7	9
45	R:R:A407	R:R:V140	15.6491	1.7	No	Yes	0	7	8
46	R:R:A407	R:R:R145	12.5369	2.77	No	No	0	7	6
47	R:R:F208	R:R:L209	45.9309	3.65	Yes	No	0	7	6
48	R:R:L159	R:R:S206	38.0059	9.01	No	No	0	9	8
49	R:R:L209	R:R:M240	41.068	4.24	No	No	0	6	6
50	L:L:?501	R:R:T197	15.3417	7.43	Yes	No	0	0	6
51	R:R:G194	R:R:T197	14.0993	3.64	No	No	0	6	6
52	R:R:G194	R:R:G195	12.38	2.11	No	No	0	6	4
53	L:L:?501	R:R:F177	10.6043	11.39	Yes	No	1	0	4
54	R:R:F177	R:R:R182	10.1588	13.9	No	No	0	4	4
55	L:L:?501	R:R:F268	14.8209	19.28	Yes	No	0	0	5
56	R:R:F268	R:R:P269	12.6561	2.89	No	No	0	5	3
57	L:L:?501	R:R:I271	33.6136	5.14	Yes	Yes	1	0	3
58	R:R:I271	R:R:Y275	28.7946	4.84	Yes	Yes	1	3	7
59	R:R:F268	R:R:I267	18.0272	17.58	No	Yes	0	5	4
60	R:R:I267	R:R:M363	23.0031	5.83	Yes	Yes	3	4	6
61	R:R:I280	R:R:M363	10.5666	2.92	Yes	Yes	3	5	6
62	R:R:W279	R:R:W356	23.9882	4.69	Yes	Yes	0	6	8
63	R:R:T283	R:R:W279	13.591	8.49	No	Yes	0	8	6
64	R:R:M363	R:R:W279	31.2418	4.65	Yes	Yes	0	6	6
65	R:R:L287	R:R:T283	13.6663	5.9	No	No	0	6	8
66	R:R:Y294	R:R:Y397	20.6438	4.96	Yes	Yes	2	9	9
67	R:R:L345	R:R:Y294	15.2036	8.21	No	Yes	0	8	9
68	R:R:L341	R:R:L345	10.1901	1.38	No	No	0	8	8
69	R:R:I267	R:R:K376	12.5996	1.45	Yes	No	0	4	2
70	R:R:K376	R:R:M371	10.7548	1.44	No	No	0	2	1
71	R:R:F170	R:R:F174	16.8852	16.08	Yes	Yes	1	7	5
72	R:R:F170	R:R:F200	18.5292	6.43	Yes	Yes	1	7	7
73	R:R:M240	R:R:S206	33.5948	3.07	No	No	0	6	8

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:?501	R:R:F170	7.01	1	Yes	Yes	0	7	0	1
L:L:?501	R:R:S173	5.4	1	Yes	No	0	4	0	1
L:L:?501	R:R:F174	5.26	1	Yes	Yes	0	5	0	1
L:L:?501	R:R:F177	11.39	1	Yes	No	0	4	0	1
L:L:?501	R:R:H178	6.48	1	Yes	Yes	0	4	0	1
L:L:?501	R:R:V196	8.58	1	Yes	No	0	7	0	1
L:L:?501	R:R:T197	7.43	1	Yes	No	0	6	0	1
L:L:?501	R:R:F200	6.14	1	Yes	Yes	0	7	0	1
L:L:?501	R:R:F268	19.28	1	Yes	No	0	5	0	1
L:L:?501	R:R:I271	5.14	1	Yes	Yes	0	3	0	1
L:L:?501	R:R:S383	5.4	1	Yes	No	0	6	0	1
R:R:H178	R:R:L111	3.86	1	Yes	No	4	4	1	2
R:R:F170	R:R:F174	16.08	1	Yes	Yes	7	5	1	1
R:R:F170	R:R:V196	9.18	1	Yes	No	7	7	1	1
R:R:F170	R:R:F200	6.43	1	Yes	Yes	7	7	1	1
R:R:F170	R:R:L387	10.96	1	Yes	No	7	7	1	2
R:R:K192	R:R:S173	7.65	0	No	No	6	4	2	1
R:R:F174	R:R:H178	4.53	1	Yes	Yes	5	4	1	1
R:R:F177	R:R:H178	10.18	1	No	Yes	4	4	1	1
R:R:F177	R:R:R182	13.9	1	No	No	4	4	1	2
R:R:F189	R:R:L193	8.53	1	Yes	No	9	4	2	2
R:R:F189	R:R:P269	8.67	1	Yes	No	9	3	2	2
R:R:F189	R:R:I271	7.54	1	Yes	Yes	9	3	2	1
R:R:L193	R:R:T197	2.95	1	No	No	4	6	2	1
R:R:I271	R:R:L193	5.71	1	Yes	No	3	4	1	2
R:R:G194	R:R:T197	3.64	0	No	No	6	6	2	1
R:R:F200	R:R:V196	6.55	1	Yes	No	7	7	1	1
R:R:C386	R:R:F200	8.38	1	No	Yes	7	7	2	1
R:R:F268	R:R:I267	17.58	0	No	Yes	5	4	1	2
R:R:F268	R:R:P269	2.89	0	No	No	5	3	1	2
R:R:I271	R:R:Y275	4.84	1	Yes	Yes	3	7	1	2
R:R:F379	R:R:S383	6.61	0	No	No	4	6	2	1
R:R:F174	R:R:S123	2.64	1	Yes	No	5	7	1	2
R:R:F174	R:R:I119	2.51	1	Yes	No	5	5	1	2

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	6N4B_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	2.67
Number of Linked Nodes	256
Number of Links	273
Number of Hubs	30
Number of Links mediated by Hubs	116
Number of Communities	6
Number of Nodes involved in Communities	36
Number of Links involved in Communities	48

Path Summary
Number Of Nodes in MetaPath	74
Number Of Links MetaPath	73
Number of Shortest Paths	37214
Length Of Smallest Path	3
Average Path Length	15.9505
Length of Longest Path	34
Minimum Path Strength	1.355
Average Path Strength	5.8407
Maximum Path Strength	18.43
Minimum Path Correlation	0.7
Average Path Correlation	0.923822
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	3.84615
Average % Of Corr. Nodes	42.8291
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	34.4573
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function	• D2 dopamine receptor binding • protein binding • binding • signaling receptor binding • G protein-coupled receptor binding • dopamine receptor binding • phosphorus-oxygen lyase activity • enzyme regulator activity • cyclase regulator activity • molecular function regulator activity • cyclase activity • adenylate cyclase regulator activity • lyase activity • catalytic activity • adenylate cyclase activity • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • cation binding • magnesium ion binding • metal ion binding • GDP binding • G protein-coupled serotonin receptor binding • protein-containing complex binding • G-protein beta/gamma-subunit complex binding • pyrophosphatase activity • GTPase activity • G protein activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • adenylate cyclase-inhibiting serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • cell communication • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular process • signal transduction
Gene Ontology	Biological Process	• cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • adenylate cyclase-inhibiting serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • cell communication • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular process • signal transduction • response to hormone • response to chemical • response to endogenous stimulus • response to peptide hormone • response to oxygen-containing compound • response to nitrogen compound • cell division • leukocyte migration • immune system process • mononuclear cell migration • lymphocyte migration • cell migration • T cell migration • cell motility • regulation of steroid biosynthetic process • regulation of cholesterol biosynthetic process • regulation of cholesterol metabolic process • steroid metabolic process • regulation of lipid metabolic process • sterol metabolic process • positive regulation of biological process • cholesterol metabolic process • lipid biosynthetic process • alcohol metabolic process • regulation of primary metabolic process • positive regulation of metabolic process • regulation of small molecule metabolic process • positive regulation of biosynthetic process • positive regulation of lipid metabolic process • small molecule metabolic process • steroid biosynthetic process • positive regulation of cellular process • regulation of biosynthetic process • secondary alcohol biosynthetic process • regulation of alcohol biosynthetic process • small molecule biosynthetic process • regulation of steroid metabolic process • cholesterol biosynthetic process • positive regulation of cholesterol biosynthetic process • primary metabolic process • secondary alcohol metabolic process • positive regulation of steroid biosynthetic process • biosynthetic process • sterol biosynthetic process • positive regulation of lipid biosynthetic process • regulation of sterol biosynthetic process • alcohol biosynthetic process • positive regulation of cholesterol metabolic process • positive regulation of steroid metabolic process • metabolic process • regulation of lipid biosynthetic process • positive regulation of small molecule metabolic process • regulation of metabolic process • positive regulation of alcohol biosynthetic process • positive regulation of sterol biosynthetic process • lipid metabolic process • regulation of cytoskeleton organization • regulation of cellular component organization • microtubule cytoskeleton organization • regulation of mitotic spindle organization • mitotic cell cycle • cellular component organization • cell cycle • cellular component organization or biogenesis • regulation of cell cycle • microtubule cytoskeleton organization involved in mitosis • spindle organization • cell cycle process • regulation of cell cycle process • regulation of microtubule-based process • regulation of spindle organization • regulation of organelle organization • mitotic spindle organization • organelle organization • mitotic cell cycle process • microtubule-based process • cytoskeleton organization • regulation of microtubule cytoskeleton organization • protein localization • positive regulation of protein localization to cell periphery • regulation of localization • protein localization to cell periphery • cellular localization • regulation of protein localization • positive regulation of protein localization to cell cortex • regulation of protein localization to cell periphery • localization • regulation of cellular localization • regulation of protein localization to cell cortex • cellular macromolecule localization • macromolecule localization • positive regulation of protein localization • protein localization to cell cortex • response to ketone • response to prostaglandin • response to lipid • response to alcohol • response to prostaglandin E • cellular response to forskolin • cellular response to oxygen-containing compound • cellular response to chemical stimulus • cellular response to alcohol • response to forskolin • cellular response to lipid • cellular response to ketone • midbody • cellular anatomical structure • membrane-bounded organelle • intracellular anatomical structure • nucleus • membrane-enclosed lumen • intracellular membraneless organelle • intracellular membrane-bounded organelle • nucleolus • intracellular organelle lumen • intracellular organelle • organelle lumen • organelle • membraneless organelle
Gene Ontology	Cellular Component	• midbody • cellular anatomical structure • membrane-bounded organelle • intracellular anatomical structure • nucleus • membrane-enclosed lumen • intracellular membraneless organelle • intracellular membrane-bounded organelle • nucleolus • intracellular organelle lumen • intracellular organelle • organelle lumen • organelle • membraneless organelle • nuclear lumen • cell periphery • cell cortex • cytoplasm • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • extracellular vesicle • extracellular organelle • extracellular region • extracellular space • vesicle • extracellular membrane-bounded organelle • centrosome • microtubule organizing center • cytoskeleton • microtubule cytoskeleton • centriolar satellite • cytosol • nucleoplasm • vacuolar membrane • lytic vacuole • vacuole • lytic vacuole membrane • bounding membrane of organelle • lysosomal membrane • organelle membrane • lysosome • Golgi apparatus • endomembrane system • cilium • plasma membrane bounded cell projection • ciliary basal body • cell projection • protein binding • binding • enzyme binding • GTPase binding • protein-containing complex binding • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • multicellular organismal process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development • anatomical structure development • sensory system development • system development • cell population proliferation • cellular process • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • signal transduction • cell communication • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • response to oxygen-containing compound • cellular response to oxygen-containing compound • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to chemical stimulus • cellular response to alcohol • response to hormone • response to chemical • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • small GTPase-mediated signal transduction • Ras protein signal transduction • intracellular signal transduction • intracellular signaling cassette • phospholipase C-activating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular response to nitrogen compound • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • response to nitrogen compound • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to monoamine stimulus • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • synaptic signaling • cellular response to acetylcholine • cell-cell signaling • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • non-motile cilium • 9+0 non-motile cilium • neuron projection • photoreceptor disc membrane • photoreceptor outer segment • photoreceptor cell cilium • synapse • cell junction • identical protein binding • molecular transducer activity • G protein-coupled receptor activity • transmembrane signaling receptor activity • signaling receptor activity • cannabinoid receptor activity • spermatogenesis • sexual reproduction • reproductive process • multicellular organismal reproductive process • developmental process involved in reproduction • male gamete generation • gamete generation • regulation of penile erection • regulation of reproductive process • mating behavior • behavior • reproductive behavior • regulation of multicellular organismal process • penile erection • copulation • positive regulation of programmed cell death • regulation of apoptotic process • positive regulation of biological process • regulation of programmed cell death • cell death • positive regulation of apoptotic process • apoptotic process • programmed cell death • positive regulation of cellular process • learning or memory • cognition • memory • monoamine transport • regulation of localization • nitrogen compound transport • negative regulation of amine transport • regulation of catecholamine secretion • transport • negative regulation of biological process • negative regulation of transport • organic hydroxy compound transport • dopamine transport • localization • secretion by cell • regulation of secretion by cell • negative regulation of secretion • catecholamine transport • negative regulation of dopamine secretion • signal release • negative regulation of cellular process • negative regulation of secretion by cell • secretion • regulation of transport • export from cell • negative regulation of catecholamine secretion • dopamine secretion • establishment of localization • regulation of secretion • catecholamine secretion • amine transport • regulation of amine transport • regulation of dopamine secretion • regulation of neuron projection development • regulation of cellular component organization • positive regulation of cellular component organization • cellular developmental process • cell projection organization • cell development • neuron projection development • cellular component organization • neurogenesis • neuron differentiation • positive regulation of neuron projection development • cell differentiation • positive regulation of cell projection organization • cellular component organization or biogenesis • plasma membrane bounded cell projection organization • regulation of cell projection organization • nervous system development • generation of neurons • neuron development • regulation of plasma membrane bounded cell projection organization • metabolic process • regulation of metabolic process • protein localization • establishment of protein localization • cellular macromolecule localization • regulation of biological quality • regulation of peptide hormone secretion • regulation of hormone levels • establishment of protein localization to extracellular region • protein secretion • regulation of protein secretion • cellular localization • regulation of hormone secretion • regulation of protein localization • regulation of peptide secretion • hormone secretion • protein localization to extracellular region • peptide secretion • amide transport • regulation of signaling • regulation of peptide transport • regulation of establishment of protein localization • regulation of protein transport • peptide transport • protein transport • regulation of cellular localization • regulation of insulin secretion • peptide hormone secretion • macromolecule localization • hormone transport • regulation of cell communication • insulin secretion • positive regulation of acute inflammatory response to antigenic stimulus • regulation of defense response • regulation of acute inflammatory response to antigenic stimulus • regulation of response to external stimulus • positive regulation of acute inflammatory response • inflammatory response to antigenic stimulus • positive regulation of response to stimulus • positive regulation of response to external stimulus • positive regulation of inflammatory response • positive regulation of immune response • response to stress • regulation of response to stress • regulation of immune system process • acute inflammatory response • positive regulation of immune system process • defense response • immune response • regulation of inflammatory response to antigenic stimulus • response to external stimulus • regulation of inflammatory response • positive regulation of inflammatory response to antigenic stimulus • acute inflammatory response to antigenic stimulus • regulation of response to stimulus • immune system process • positive regulation of defense response • regulation of acute inflammatory response • regulation of immune response • inflammatory response • neuron recognition • neuron projection fasciculation • axonal fasciculation • cell recognition • axon development • inorganic ion homeostasis • intracellular calcium ion homeostasis • homeostatic process • calcium ion homeostasis • regulation of cytosolic calcium ion concentration • regulation of presynaptic cytosolic calcium ion concentration • cellular homeostasis • neuron cellular homeostasis • chemical homeostasis • intracellular monoatomic cation homeostasis • monoatomic ion homeostasis • intracellular chemical homeostasis • monoatomic cation homeostasis • intracellular monoatomic ion homeostasis • regulation of behavior • feeding behavior • regulation of feeding behavior • glucose homeostasis • carbohydrate homeostasis • G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger • cannabinoid signaling pathway • negative regulation of monoatomic ion transport • monoatomic ion transport • serotonin secretion • negative regulation of serotonin secretion • regulation of monoatomic ion transport • serotonin transport • regulation of serotonin secretion • trans-synaptic signaling • synaptic transmission, GABAergic • modulation of chemical synaptic transmission • chemical synaptic transmission • regulation of trans-synaptic signaling • anterograde trans-synaptic signaling • regulation of synaptic transmission, GABAergic • multi-multicellular organism process • maternal process involved in female pregnancy • female pregnancy • multi-organism reproductive process • circulatory system process • regulation of blood pressure • positive regulation of blood pressure • blood circulation • response to ethanol • regulation of action potential • negative regulation of action potential • action potential • regulation of membrane potential • trans-synaptic signaling by endocannabinoid • retrograde trans-synaptic signaling • retrograde trans-synaptic signaling by endocannabinoid • trans-synaptic signaling by lipid • retrograde trans-synaptic signaling by lipid • regulation of leukocyte activation • cell activation • regulation of cell activation • myeloid leukocyte activation • leukocyte activation • negative regulation of cell activation • negative regulation of mast cell activation • negative regulation of immune system process • mast cell activation • regulation of mast cell activation • negative regulation of multicellular organismal process • negative regulation of leukocyte activation • synaptic transmission, glutamatergic • regulation of synaptic transmission, glutamatergic • response to nutrient levels • response to nutrient • response to nicotine • biological process involved in interspecies interaction between organisms • response to other organism • response to lipopolysaccharide • response to biotic stimulus • response to bacterium • response to external biotic stimulus • response to molecule of bacterial origin • response to cocaine • response to alkaloid • acute-phase response • regulation of heat generation • positive regulation of heat generation • heat generation • positive regulation of fever generation • fever generation • multicellular organismal-level homeostasis • temperature homeostasis • positive regulation of multicellular organismal process • regulation of fever generation • negative regulation of blood pressure • catabolic process • negative regulation of fatty acid oxidation • negative regulation of small molecule metabolic process • negative regulation of fatty acid beta-oxidation • oxoacid metabolic process • ketone metabolic process • regulation of lipid metabolic process • organic acid metabolic process • organic acid catabolic process • regulation of primary metabolic process • regulation of fatty acid oxidation • monocarboxylic acid catabolic process • fatty acid oxidation • regulation of small molecule metabolic process • carboxylic acid catabolic process • fatty acid beta-oxidation • small molecule metabolic process • lipid oxidation • negative regulation of lipid catabolic process • negative regulation of catabolic process • fatty acid metabolic process • lipid catabolic process • negative regulation of fatty acid metabolic process • negative regulation of metabolic process • regulation of fatty acid beta-oxidation • carboxylic acid metabolic process • primary metabolic process • lipid modification • regulation of catabolic process • regulation of lipid catabolic process • regulation of ketone metabolic process • fatty acid catabolic process • regulation of fatty acid metabolic process • monocarboxylic acid metabolic process • small molecule catabolic process • negative regulation of lipid metabolic process • lipid metabolic process • actin cytoskeleton • presynapse • presynaptic membrane • plasma membrane region • synaptic membrane • glutamatergic synapse • mitochondrial membrane • mitochondrion • organelle outer membrane • organelle envelope • mitochondrial envelope • mitochondrial outer membrane • outer membrane • membrane microdomain • membrane raft • growth cone • axon • distal axon • site of polarized growth • GABA-ergic synapse • G-protein beta-subunit binding • fibroblast proliferation
SCOP2	Domain Identifier	• Ras-like P-loop GTPases • G protein-coupled receptor-like • Transducin (heterotrimeric G protein), gamma chain
SCOP2	Family Identifier	• Ras-like P-loop GTPases • G protein-coupled receptor-like • Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	KCA
PDB Residues	L:L:?501
Environment Details	Open EMBL-EBI Page
Code	KCA
Name	methyl N-{1-[(4-fluorophenyl)methyl]-1H-indazole-3-carbonyl}-3-methyl-L-valinate
Synonyms
Identifier
Formula	C22 H24 F N3 O3
Molecular Weight	397.443
SMILES
PubChem	119025665
Formal Charge	0
Total Atoms	53
Total Chiral Atoms	1
Total Bonds	55
Total Aromatic Bonds	16


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P21554
Sequence	>6N4B_nogp_Chain_R M V L N P S Q Q L A I A V L S L T L G T F T V L E N L L V L C V I L H S R S L R C R P S Y H F I G S L A V A D L L G S V I F V Y S F I D F H V F H R K D S R N V F L F K L G G V T A S F T A S V G S L F L T A I D R Y I S I H R P L A Y K R I V T R P K A V V A F C L M W T I A I V I A V L P L L G W N C C S D I F P H I D E T Y L M F W I G V T S V L L L F I V Y A Y M Y I L W K A H S H A V R M I Q R G T A R M D I R L A K T L V L I L V V L I I C W G P L L A I M V Y D V F G K M N K L I K T V F A F C S M L C L L N S T V N P I I Y A L R S K D L R H A F R S M Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	9B65	A	Lipid	Cannabinoid	CB₁	Homo sapiens	KCA	-	Gi1/β1/γ2	3.03	2025-03-05	10.1038/s41586-025-08618-7
	9B65 (No Gprot)	A	Lipid	Cannabinoid	CB₁	Homo sapiens	KCA	-		3.03	2025-03-05	10.1038/s41586-025-08618-7
	9B54	A	Lipid	Cannabinoid	CB₁	Homo sapiens	A1AIW	-	Gi1/β1/γ2	2.86	2025-03-05	10.1038/s41586-025-08618-7
	9B54 (No Gprot)	A	Lipid	Cannabinoid	CB₁	Homo sapiens	A1AIW	-		2.86	2025-03-05	10.1038/s41586-025-08618-7
	9BA0	A	Lipid	Cannabinoid	CB₁	Homo sapiens	A1AKN	-	-	3.13	2024-11-20	10.1038/s41467-024-54206-0
	9B9Z	A	Lipid	Cannabinoid	CB₁	Homo sapiens	A1AKO	-	-	3.3	2024-11-20	10.1038/s41467-024-54206-0
	9B9Y	A	Lipid	Cannabinoid	CB₁	Homo sapiens	7DY	-	-	3.5	2024-11-20	10.1038/s41467-024-54206-0
	9ERX	A	Lipid	Cannabinoid	CB₁	Homo sapiens	D9-THC analog	-	Gi1/β1/γ2	2.9	2024-06-26	10.21203/rs.3.rs-4277209/v1
	9ERX (No Gprot)	A	Lipid	Cannabinoid	CB₁	Homo sapiens	D9-THC analog	-		2.9	2024-06-26	10.21203/rs.3.rs-4277209/v1
	8IKH	A	Lipid	Cannabinoid	CB₁	Homo sapiens	-	Q2L	Gi1/β1/γ1	3.3	2024-06-05	10.1073/pnas.2321532121
	8IKH (No Gprot)	A	Lipid	Cannabinoid	CB₁	Homo sapiens	-	Q2L		3.3	2024-06-05	10.1073/pnas.2321532121
	8IKG	A	Lipid	Cannabinoid	CB₁	Homo sapiens	-	Q2B	Gi1/β1/γ1	3.4	2024-06-05	10.1073/pnas.2321532121
	8IKG (No Gprot)	A	Lipid	Cannabinoid	CB₁	Homo sapiens	-	Q2B		3.4	2024-06-05	10.1073/pnas.2321532121
	8WU1	A	Lipid	Cannabinoid	CB₁	Homo sapiens	PubChem 119025665	-	Arrestin2	3.2	2024-03-20	To be published
	8WRZ	A	Lipid	Cannabinoid	CB₁	Homo sapiens	PubChem 102336704	-	Arrestin2	3.6	2024-02-28	10.1093/procel/pwad055
	8GAG	A	Lipid	Cannabinoid	CB₁	Homo sapiens	PubChem 170838490	-	Gi1/β1/γ2	3.3	2024-02-28	To be published
	8GAG (No Gprot)	A	Lipid	Cannabinoid	CB₁	Homo sapiens	PubChem 170838490	-		3.3	2024-02-28	To be published
	8K8J	A	Lipid	Cannabinoid	CB₁	Homo sapiens	Fenofibrate	-	chim(Gs-CtGq)/β1/γ2	2.88	2024-02-14	10.1002/advs.202306311
	8K8J (No Gprot)	A	Lipid	Cannabinoid	CB₁	Homo sapiens	Fenofibrate	-		2.88	2024-02-14	10.1002/advs.202306311
	8GHV	A	Lipid	Cannabinoid	CB₁	Homo sapiens	AMG315	-	Gi1/β1/γ2	2.8	2023-05-24	10.1038/s41467-023-37864-4
	8GHV (No Gprot)	A	Lipid	Cannabinoid	CB₁	Homo sapiens	AMG315	-		2.8	2023-05-24	10.1038/s41467-023-37864-4
	7FEE	A	Lipid	Cannabinoid	CB₁	Homo sapiens	CP55940	ZCZ011	-	2.7	2022-06-15	10.1038/s41589-022-01038-y
	7WV9	A	Lipid	Cannabinoid	CB₁	Homo sapiens	CP55940	ZCZ011	Gi2/β1/γ2	3.36	2022-06-15	10.1038/s41589-022-01038-y
	7WV9 (No Gprot)	A	Lipid	Cannabinoid	CB₁	Homo sapiens	CP55940	ZCZ011		3.36	2022-06-15	10.1038/s41589-022-01038-y
	7V3Z	A	Lipid	Cannabinoid	CB₁	Homo sapiens	CP55940	-	-	3.29	2021-11-24	10.1021/jacs.1c06847
	6KPG	A	Lipid	Cannabinoid	CB₁	Homo sapiens	AM841	-	Gi1/β1/γ2	3	2020-02-12	10.1016/j.cell.2020.01.008
	6KPG (No Gprot)	A	Lipid	Cannabinoid	CB₁	Homo sapiens	AM841	-		3	2020-02-12	10.1016/j.cell.2020.01.008
	6KQI	A	Lipid	Cannabinoid	CB₁	Homo sapiens	CP55940	Org27569	-	3.25	2019-10-23	10.1038/s41589-019-0387-2
	6N4B	A	Lipid	Cannabinoid	CB₁	Homo sapiens	MDMB-Fubinaca	-	Gi1/β1/γ2	3	2019-01-30	10.1016/j.cell.2018.11.040
	6N4B (No Gprot)	A	Lipid	Cannabinoid	CB₁	Homo sapiens	MDMB-Fubinaca	-		3	2019-01-30	10.1016/j.cell.2018.11.040
	5XRA	A	Lipid	Cannabinoid	CB₁	Homo sapiens	AM11542	-	-	2.8	2017-07-12	10.1038/nature23272
	5XR8	A	Lipid	Cannabinoid	CB₁	Homo sapiens	AM841	-	-	2.95	2017-07-12	10.1038/nature23272
	5U09	A	Lipid	Cannabinoid	CB₁	Homo sapiens	Taranabant	-	-	2.6	2016-12-07	10.1038/nature20613
	5TGZ	A	Lipid	Cannabinoid	CB₁	Homo sapiens	AM6538	-	-	2.8	2016-11-02	10.1016/j.cell.2016.10.004

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