psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:F170	4.51	Yes	Yes	1	0	7
2	L:L:?1	R:R:S173	6.66	Yes	No	1	0	4
3	L:L:?1	R:R:F174	2.7	Yes	Yes	1	0	5
4	L:L:?1	R:R:F177	3.6	Yes	No	0	0	4
5	L:L:?1	R:R:F189	5.41	Yes	Yes	1	0	9
6	L:L:?1	R:R:K192	2.09	Yes	Yes	1	0	6
7	L:L:?1	R:R:L193	6.14	Yes	No	1	0	4
8	L:L:?1	R:R:V196	2.2	Yes	No	1	0	7
9	L:L:?1	R:R:T197	10.9	Yes	No	0	0	6
10	L:L:?1	R:R:F268	25.23	Yes	Yes	1	0	5
11	L:L:?1	R:R:L276	2.05	Yes	No	1	0	5
12	L:L:?1	R:R:W279	10.11	Yes	Yes	0	0	6
13	L:L:?1	R:R:S383	5.55	Yes	No	1	0	6
14	R:R:F108	R:R:M109	8.71	No	No	0	5	3
15	R:R:F108	R:R:V110	2.62	No	No	0	5	3
16	R:R:F177	R:R:M109	8.71	No	No	0	4	3
17	R:R:K373	R:R:V110	3.04	No	No	0	3	3
18	R:R:L111	R:R:Q116	5.32	No	No	0	4	4
19	R:R:H178	R:R:L111	5.14	No	No	0	4	4
20	R:R:N112	R:R:P113	11.4	No	No	4	6	2
21	R:R:N112	R:R:S114	2.98	No	No	4	6	5
22	R:R:N112	R:R:Q115	10.56	No	No	0	6	2
23	R:R:P113	R:R:S114	1.78	No	No	4	2	5
24	R:R:Q116	R:R:V179	4.3	No	No	0	4	4
25	R:R:F174	R:R:I119	3.77	Yes	No	0	5	5
26	R:R:F381	R:R:I119	5.02	No	No	0	4	5
27	R:R:L122	R:R:L126	4.15	No	No	0	5	6
28	R:R:L122	R:R:M384	2.83	No	Yes	0	5	5
29	R:R:S123	R:R:V171	4.85	No	No	0	7	7
30	R:R:M384	R:R:S123	3.07	Yes	No	0	5	7
31	R:R:F129	R:R:T125	5.19	No	No	0	4	4
32	R:R:L126	R:R:L387	2.77	No	Yes	0	6	7
33	R:R:G127	R:R:T130	1.82	No	Yes	5	6	7
34	R:R:G127	R:R:S167	1.86	No	No	5	6	7
35	R:R:G127	R:R:L387	1.71	No	Yes	0	6	7
36	R:R:N134	R:R:T130	4.39	No	Yes	0	9	7
37	R:R:S167	R:R:T130	3.2	No	Yes	5	7	7
38	R:R:S390	R:R:T130	9.59	No	Yes	0	9	7
39	R:R:T130	R:R:T391	6.28	Yes	No	0	7	7
40	R:R:L164	R:R:V131	4.47	No	No	0	7	6
41	R:R:N134	R:R:P394	4.89	No	No	0	9	9
42	R:R:P394	R:R:V137	1.77	No	No	0	9	9
43	R:R:I141	R:R:Y153	3.63	No	Yes	0	7	9
44	R:R:P151	R:R:R150	2.88	No	No	0	5	5
45	R:R:R150	R:R:Y153	12.35	No	Yes	6	5	9
46	R:R:D403	R:R:R150	9.53	No	No	6	6	5
47	R:R:P151	R:R:R230	7.21	No	No	0	5	1
48	R:R:D213	R:R:S152	4.42	Yes	No	0	9	8
49	R:R:I156	R:R:Y153	2.42	No	Yes	0	8	9
50	R:R:D403	R:R:Y153	3.45	No	Yes	6	6	9
51	R:R:L404	R:R:Y153	10.55	No	Yes	0	8	9
52	R:R:H154	R:R:V234	2.77	No	No	0	3	1
53	R:R:F155	R:R:L209	10.96	Yes	No	0	8	6
54	R:R:D213	R:R:F155	2.39	Yes	Yes	0	9	8
55	R:R:A236	R:R:F155	2.77	No	Yes	0	5	8
56	R:R:A160	R:R:G157	1.95	No	No	0	9	6
57	R:R:S158	R:R:S206	4.89	No	No	0	9	8
58	R:R:F237	R:R:S158	2.64	Yes	No	0	8	9
59	R:R:L159	R:R:S206	6.01	No	No	0	9	8
60	R:R:L159	R:R:Y397	3.52	No	Yes	0	9	9
61	R:R:A162	R:R:A202	1.79	No	No	2	8	7
62	R:R:A162	R:R:S203	1.71	No	No	0	8	9
63	R:R:A162	R:R:W241	2.59	No	Yes	2	8	9
64	R:R:D163	R:R:S390	11.78	No	No	0	9	9
65	R:R:G166	R:R:L165	1.71	No	No	0	8	6
66	R:R:G166	R:R:S199	3.71	No	No	0	8	7
67	R:R:F170	R:R:F174	4.29	Yes	Yes	1	7	5
68	R:R:F170	R:R:V196	3.93	Yes	No	1	7	7
69	R:R:F170	R:R:S383	5.28	Yes	No	1	7	6
70	R:R:F170	R:R:L387	2.44	Yes	Yes	0	7	7
71	R:R:L387	R:R:V171	4.47	Yes	No	0	7	7
72	R:R:K192	R:R:S173	9.18	Yes	No	1	6	4
73	R:R:F174	R:R:H178	10.18	Yes	No	0	5	4
74	R:R:A380	R:R:F174	2.77	No	Yes	0	4	5
75	R:R:F174	R:R:M384	2.49	Yes	Yes	0	5	5
76	R:R:I175	R:R:V179	3.07	No	No	0	5	4
77	R:R:D176	R:R:R182	17.87	No	No	0	3	4
78	R:R:D176	R:R:K192	2.77	No	Yes	0	3	6
79	R:R:F177	R:R:H178	10.18	No	No	0	4	4
80	R:R:D184	R:R:V188	11.69	No	No	0	2	5
81	R:R:R186	R:R:S185	9.22	No	No	0	3	7
82	R:R:N187	R:R:V188	4.43	No	No	0	1	5
83	R:R:F189	R:R:L190	2.44	Yes	No	0	9	5
84	R:R:F189	R:R:L193	2.44	Yes	No	1	9	4
85	R:R:F189	R:R:P269	5.78	Yes	No	0	9	3
86	R:R:I271	R:R:L193	4.28	No	No	0	3	4
87	R:R:G194	R:R:G195	2.11	No	No	0	6	4
88	R:R:A248	R:R:G194	1.95	No	No	0	7	6
89	R:R:F200	R:R:V196	2.62	No	No	0	7	7
90	R:R:A248	R:R:T197	3.36	No	No	0	7	6
91	R:R:A198	R:R:A248	1.79	No	No	0	5	7
92	R:R:C386	R:R:F200	8.38	No	No	0	7	7
93	R:R:A202	R:R:W241	7.78	No	Yes	2	7	9
94	R:R:L286	R:R:V204	4.47	Yes	No	0	8	7
95	R:R:V204	R:R:W356	4.9	No	Yes	0	7	8
96	R:R:G205	R:R:M240	1.75	No	Yes	0	5	6
97	R:R:G205	R:R:L286	1.71	No	Yes	0	5	8
98	R:R:M240	R:R:S206	4.6	Yes	No	0	6	8
99	R:R:L207	R:R:Y397	3.52	No	Yes	0	8	9
100	R:R:F208	R:R:L286	6.09	No	Yes	0	7	8
101	R:R:F208	R:R:F289	4.29	No	No	0	7	6
102	R:R:A211	R:R:A293	1.79	No	No	0	8	7
103	R:R:A211	R:R:Y294	4	No	Yes	0	8	9
104	R:R:D213	R:R:Y224	6.9	Yes	No	7	9	7
105	R:R:D213	R:R:V228	4.38	Yes	No	7	9	6
106	R:R:R214	R:R:Y294	4.12	No	Yes	0	9	9
107	R:R:H219	R:R:Y215	4.36	No	No	9	6	8
108	R:R:Y215	R:R:Y296	8.94	No	No	9	8	4
109	R:R:S217	R:R:Y224	5.09	No	No	0	8	7
110	R:R:I218	R:R:I297	4.42	No	No	0	9	9
111	R:R:I218	R:R:K300	2.91	No	No	0	9	5
112	R:R:H219	R:R:R220	6.77	No	No	0	6	5
113	R:R:H219	R:R:Y296	8.71	No	No	9	6	4
114	R:R:A223	R:R:R226	2.77	No	No	0	5	4
115	R:R:V228	R:R:Y224	3.79	No	No	7	6	7
116	R:R:P231	R:R:T229	10.49	No	No	0	4	8
117	R:R:K232	R:R:T229	4.5	No	No	0	5	8
118	R:R:F237	R:R:M240	2.49	Yes	Yes	2	8	6
119	R:R:F237	R:R:W241	2	Yes	Yes	2	8	9
120	R:R:M240	R:R:W241	6.98	Yes	Yes	2	6	9
121	R:R:F278	R:R:I247	3.77	No	No	0	6	5
122	R:R:P251	R:R:Y275	6.95	No	Yes	0	6	7
123	R:R:D266	R:R:E273	3.9	No	No	0	4	3
124	R:R:D266	R:R:D366	5.32	No	No	0	4	4
125	R:R:F268	R:R:I267	2.51	Yes	Yes	1	5	4
126	R:R:D366	R:R:I267	11.2	No	Yes	0	4	4
127	R:R:I267	R:R:K376	2.91	Yes	No	0	4	2
128	R:R:F379	R:R:I267	7.54	Yes	Yes	1	4	4
129	R:R:F268	R:R:I271	2.51	Yes	No	0	5	3
130	R:R:F268	R:R:L276	2.44	Yes	No	1	5	5
131	R:R:F268	R:R:F379	3.22	Yes	Yes	1	5	4
132	R:R:H270	R:R:P269	4.58	No	No	0	3	3
133	R:R:I271	R:R:Y275	3.63	No	Yes	0	3	7
134	R:R:D272	R:R:T274	2.89	No	No	0	5	5
135	R:R:D272	R:R:Y275	3.45	No	Yes	0	5	7
136	R:R:M277	R:R:V367	4.56	No	No	0	4	4
137	R:R:T283	R:R:W279	8.49	No	Yes	0	8	6
138	R:R:M363	R:R:W279	3.49	No	Yes	0	6	6
139	R:R:I280	R:R:M363	4.37	No	No	0	5	6
140	R:R:G281	R:R:S284	1.86	No	No	0	3	5
141	R:R:S284	R:R:V285	3.23	No	No	0	5	6
142	R:R:L287	R:R:L352	2.77	No	No	0	6	9
143	R:R:L287	R:R:W356	2.28	No	Yes	0	6	8
144	R:R:I290	R:R:Y294	2.42	No	Yes	0	8	9
145	R:R:L349	R:R:V291	2.98	No	No	0	8	5
146	R:R:L345	R:R:Y294	10.55	No	Yes	0	8	9
147	R:R:L349	R:R:Y294	3.52	No	Yes	0	8	9
148	R:R:K300	R:R:Y296	4.78	No	No	0	5	4
149	R:R:I297	R:R:L345	2.85	No	No	0	9	8
150	R:R:L298	R:R:L345	2.77	No	No	0	6	8
151	R:R:D338	R:R:H302	16.39	No	No	0	7	5
152	R:R:H304	R:R:M308	5.25	No	No	0	7	7
153	R:R:A305	R:R:D338	4.63	No	No	0	5	7
154	R:R:R307	R:R:R311	7.46	No	No	0	4	5
155	R:R:D338	R:R:I339	2.8	No	No	0	7	5
156	R:R:R400	R:R:T344	5.17	No	No	0	7	8
157	R:R:I348	R:R:L349	2.85	No	No	0	8	8
158	R:R:I348	R:R:I396	2.94	No	Yes	8	8	9
159	R:R:I348	R:R:Y397	3.63	No	Yes	8	8	9
160	R:R:I396	R:R:V351	3.07	Yes	No	0	9	6
161	R:R:C355	R:R:L388	4.76	No	No	0	8	5
162	R:R:C355	R:R:N389	7.87	No	No	0	8	9
163	R:R:L360	R:R:W356	3.42	No	Yes	0	7	8
164	R:R:N389	R:R:W356	4.52	No	Yes	0	9	8
165	R:R:G357	R:R:P358	4.06	No	No	0	5	9
166	R:R:C382	R:R:P358	1.88	No	No	0	5	9
167	R:R:L385	R:R:P358	4.93	No	No	0	7	9
168	R:R:L359	R:R:L360	2.77	No	No	0	7	7
169	R:R:L359	R:R:L385	2.77	No	No	0	7	7
170	R:R:F379	R:R:I362	3.77	Yes	No	0	4	4
171	R:R:C382	R:R:I362	3.27	No	No	0	5	4
172	R:R:F379	R:R:M363	2.49	Yes	No	0	4	6
173	R:R:M371	R:R:Y365	7.18	Yes	No	3	1	4
174	R:R:N372	R:R:Y365	4.65	No	No	3	1	4
175	R:R:I375	R:R:Y365	8.46	No	No	3	3	4
176	R:R:D366	R:R:M371	5.54	No	Yes	0	4	1
177	R:R:G369	R:R:K370	1.74	No	No	0	3	1
178	R:R:I375	R:R:M371	8.75	No	Yes	3	3	1
179	R:R:K376	R:R:M371	2.88	No	Yes	0	2	1
180	R:R:I375	R:R:N372	4.25	No	No	3	3	1
181	R:R:L387	R:R:M384	5.65	Yes	Yes	0	7	5
182	R:R:N389	R:R:N393	5.45	No	No	0	9	9
183	R:R:I395	R:R:V392	3.07	No	No	0	6	6
184	R:R:I396	R:R:V392	3.07	Yes	No	0	9	6
185	R:R:I396	R:R:Y397	3.63	Yes	Yes	8	9	9
186	R:R:A398	R:R:V137	1.7	No	No	0	7	9
187	R:R:A244	R:R:T201	1.68	No	No	0	8	6
188	R:R:L250	R:R:P251	1.64	No	No	0	5	6
189	R:R:L253	R:R:P251	1.64	No	No	0	5	6
190	R:R:S185	R:R:V188	1.62	No	No	0	7	5
191	R:R:A198	R:R:I245	1.62	No	No	0	5	4
192	R:R:A301	R:R:M337	1.61	No	No	0	8	6
193	R:R:A305	R:R:M337	1.61	No	No	0	5	6
194	R:R:V131	R:R:V168	1.6	No	No	0	6	4
195	R:R:A342	R:R:L298	1.58	No	No	0	7	6
196	R:R:A301	R:R:L341	1.58	No	No	0	8	8
197	R:R:A398	R:R:L404	1.58	No	No	0	7	8
198	R:R:E133	R:R:P394	1.57	No	No	0	8	9
199	R:R:I169	R:R:S173	1.55	No	No	0	5	4
200	R:R:I218	R:R:S217	1.55	No	No	0	9	8
201	R:R:I227	R:R:V228	1.54	No	No	0	4	6
202	R:R:I245	R:R:V249	1.54	No	No	0	4	5
203	R:R:I354	R:R:V350	1.54	No	No	0	5	6
204	R:R:M411	R:R:V140	1.52	No	No	0	5	8
205	R:R:I243	R:R:T242	1.52	No	No	0	5	4
206	R:R:M295	R:R:V291	1.52	No	No	0	3	5
207	R:R:L165	R:R:V161	1.49	No	No	0	6	6
208	R:R:L276	R:R:V367	1.49	No	No	0	5	4
209	R:R:L286	R:R:V285	1.49	Yes	No	0	8	6
210	R:R:L347	R:R:V350	1.49	No	No	0	7	6
211	R:R:L126	R:R:T125	1.47	No	No	0	6	4
212	R:R:L239	R:R:T242	1.47	No	No	0	3	4
213	R:R:I353	R:R:I354	1.47	No	No	0	6	5
214	R:R:P221	R:R:R220	1.44	No	No	0	8	5
215	R:R:P231	R:R:R230	1.44	No	No	0	4	1
216	R:R:I141	R:R:L138	1.43	No	No	0	7	7
217	R:R:I212	R:R:L209	1.43	No	No	0	7	6
218	R:R:I297	R:R:L341	1.43	No	No	0	9	8
219	R:R:K373	R:R:L374	1.41	No	No	0	3	4
220	R:R:C149	R:R:R148	1.39	No	No	0	7	8
221	R:R:D403	R:R:K402	1.38	No	No	0	6	5
222	R:R:R307	R:R:S303	1.32	No	No	0	4	5
223	R:R:H181	R:R:M109	1.31	No	No	0	3	3
224	R:R:F408	R:R:V140	1.31	No	No	0	7	8
225	R:R:F237	R:R:V234	1.31	Yes	No	0	8	1
226	R:R:H304	R:R:M337	1.31	No	No	0	7	6
227	R:R:F368	R:R:V364	1.31	No	No	0	5	6
228	R:R:F129	R:R:T128	1.3	No	No	0	4	5
229	R:R:F155	R:R:T210	1.3	Yes	No	0	8	9
230	R:R:F191	R:R:K192	1.24	No	Yes	0	5	6
231	R:R:M308	R:R:R307	1.24	No	No	0	7	4
232	R:R:K402	R:R:R405	1.24	No	No	0	5	8
233	R:R:I175	R:R:Y172	1.21	No	No	0	5	7
234	R:R:T201	R:R:W279	1.21	No	Yes	0	6	6
235	R:R:I216	R:R:Y215	1.21	No	No	0	5	8
236	R:R:I247	R:R:Y275	1.21	No	Yes	0	5	7
237	R:R:D184	R:R:R182	1.19	No	No	0	2	4
238	R:R:D184	R:R:F189	1.19	No	Yes	0	2	9

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	L:L:?1	6.70385	13	1	0
2	R:R:T130	5.056	5	5	7
3	R:R:Y153	6.48	5	6	9
4	R:R:F155	4.355	4	0	8
5	R:R:F170	4.09	5	1	7
6	R:R:F174	4.36667	6	1	5
7	R:R:F189	3.452	5	1	9
8	R:R:K192	3.82	4	1	6
9	R:R:D213	4.5225	4	7	9
10	R:R:F237	2.11	4	2	8
11	R:R:M240	3.955	4	2	6
12	R:R:W241	4.8375	4	2	9
13	R:R:I267	6.04	4	1	4
14	R:R:F268	7.182	5	1	5
15	R:R:Y275	3.81	4	0	7
16	R:R:W279	5.825	4	0	6
17	R:R:L286	3.44	4	0	8
18	R:R:Y294	4.922	5	0	9
19	R:R:W356	3.78	4	0	8
20	R:R:M371	6.0875	4	3	1
21	R:R:F379	4.255	4	1	4
22	R:R:M384	3.51	4	0	5
23	R:R:L387	3.408	5	0	7
24	R:R:I396	3.1775	4	8	9
25	R:R:Y397	3.575	4	8	9

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:F177	22.3434	3.6	Yes	No	0	0	4
2	R:R:F177	R:R:M109	12.2626	8.71	No	No	0	4	3
3	L:L:?1	R:R:F174	19.7818	2.7	Yes	Yes	1	0	5
4	R:R:F174	R:R:H178	14.2593	10.18	Yes	No	0	5	4
5	R:R:H178	R:R:L111	19.5188	5.14	No	No	0	4	4
6	R:R:F177	R:R:H178	10.0516	10.18	No	No	0	4	4
7	R:R:L111	R:R:Q116	15.6521	5.32	No	No	0	4	4
8	R:R:Q116	R:R:V179	11.7659	4.3	No	No	0	4	4
9	L:L:?1	R:R:F170	49.2841	4.51	Yes	Yes	1	0	7
10	R:R:F170	R:R:L387	52.6541	2.44	Yes	Yes	0	7	7
11	R:R:G127	R:R:L387	47.492	1.71	No	Yes	0	6	7
12	R:R:G127	R:R:T130	43.8979	1.82	No	Yes	5	6	7
13	R:R:N134	R:R:T130	37.1481	4.39	No	Yes	0	9	7
14	R:R:N134	R:R:P394	35.356	4.89	No	No	0	9	9
15	R:R:P394	R:R:V137	31.7133	1.77	No	No	0	9	9
16	R:R:A398	R:R:V137	29.8627	1.7	No	No	0	7	9
17	R:R:A398	R:R:L404	27.9926	1.58	No	No	0	7	8
18	R:R:L404	R:R:Y153	26.0836	10.55	No	Yes	0	8	9
19	R:R:R150	R:R:Y153	12.3795	12.35	No	Yes	6	5	9
20	R:R:P151	R:R:R150	10.5094	2.88	No	No	0	5	5
21	L:L:?1	R:R:F268	92.2178	25.23	Yes	Yes	1	0	5
22	R:R:F268	R:R:F379	83.072	3.22	Yes	Yes	1	5	4
23	R:R:F379	R:R:I362	100	3.77	Yes	No	0	4	4
24	R:R:C382	R:R:I362	99.6104	3.27	No	No	0	5	4
25	R:R:C382	R:R:P358	99.2013	1.88	No	No	0	5	9
26	R:R:L385	R:R:P358	98.3247	4.93	No	No	0	7	9
27	R:R:L359	R:R:L385	97.8572	2.77	No	No	0	7	7
28	R:R:L359	R:R:L360	97.3702	2.77	No	No	0	7	7
29	R:R:L360	R:R:W356	96.8637	3.42	No	Yes	0	7	8
30	R:R:V204	R:R:W356	92.773	4.9	No	Yes	0	7	8
31	R:R:L286	R:R:V204	92.1106	4.47	Yes	No	0	8	7
32	R:R:G205	R:R:L286	87.7277	1.71	No	Yes	0	5	8
33	R:R:G205	R:R:M240	86.929	1.75	No	Yes	0	5	6
34	R:R:M240	R:R:S206	78.2799	4.6	Yes	No	0	6	8
35	R:R:L159	R:R:S206	77.8514	6.01	No	No	0	9	8
36	R:R:L159	R:R:Y397	76.7313	3.52	No	Yes	0	9	9
37	R:R:I348	R:R:Y397	68.3744	3.63	No	Yes	8	8	9
38	R:R:I348	R:R:L349	68.8614	2.85	No	No	0	8	8
39	R:R:L349	R:R:Y294	65.17	3.52	No	Yes	0	8	9
40	R:R:L345	R:R:Y294	58.9559	10.55	No	Yes	0	8	9
41	R:R:I297	R:R:L345	54.7482	2.85	No	No	0	9	8
42	R:R:I218	R:R:I297	34.6839	4.42	No	No	0	9	9
43	R:R:I218	R:R:S217	20.9019	1.55	No	No	0	9	8
44	R:R:S217	R:R:Y224	19.0708	5.09	No	No	0	8	7
45	R:R:D213	R:R:Y224	13.295	6.9	Yes	No	7	9	7
46	L:L:?1	R:R:F189	17.5709	5.41	Yes	Yes	1	0	9
47	R:R:D184	R:R:F189	11.5613	1.19	No	Yes	0	2	9
48	R:R:F268	R:R:I271	16.9183	2.51	Yes	No	0	5	3
49	L:L:?1	R:R:T197	13.8892	10.9	Yes	No	0	0	6
50	R:R:A248	R:R:T197	12.2041	3.36	No	No	0	7	6
51	R:R:I218	R:R:K300	13.7138	2.91	No	No	0	9	5
52	R:R:K300	R:R:Y296	11.8438	4.78	No	No	0	5	4
53	R:R:I271	R:R:Y275	21.1357	3.63	No	Yes	0	3	7
54	R:R:F268	R:R:I267	15.3307	2.51	Yes	Yes	1	5	4
55	R:R:D366	R:R:I267	15.3696	11.2	No	Yes	0	4	4
56	R:R:I267	R:R:K376	11.5321	2.91	Yes	No	0	4	2
57	R:R:I297	R:R:L341	22.957	1.43	No	No	0	9	8
58	R:R:A301	R:R:L341	21.1844	1.58	No	No	0	8	8
59	R:R:A301	R:R:M337	19.3435	1.61	No	No	0	8	6
60	R:R:F379	R:R:I267	13.2074	7.54	Yes	Yes	1	4	4

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:?1	R:R:F170	4.51	1	Yes	Yes	0	7	0	1
L:L:?1	R:R:S173	6.66	1	Yes	No	0	4	0	1
L:L:?1	R:R:F174	2.7	1	Yes	Yes	0	5	0	1
L:L:?1	R:R:F177	3.6	1	Yes	No	0	4	0	1
L:L:?1	R:R:F189	5.41	1	Yes	Yes	0	9	0	1
L:L:?1	R:R:K192	2.09	1	Yes	Yes	0	6	0	1
L:L:?1	R:R:L193	6.14	1	Yes	No	0	4	0	1
L:L:?1	R:R:V196	2.2	1	Yes	No	0	7	0	1
L:L:?1	R:R:T197	10.9	1	Yes	No	0	6	0	1
L:L:?1	R:R:F268	25.23	1	Yes	Yes	0	5	0	1
L:L:?1	R:R:L276	2.05	1	Yes	No	0	5	0	1
L:L:?1	R:R:W279	10.11	1	Yes	Yes	0	6	0	1
L:L:?1	R:R:S383	5.55	1	Yes	No	0	6	0	1
R:R:F177	R:R:M109	8.71	0	No	No	4	3	1	2
R:R:F174	R:R:I119	3.77	1	Yes	No	5	5	1	2
R:R:F170	R:R:F174	4.29	1	Yes	Yes	7	5	1	1
R:R:F170	R:R:V196	3.93	1	Yes	No	7	7	1	1
R:R:F170	R:R:S383	5.28	1	Yes	No	7	6	1	1
R:R:F170	R:R:L387	2.44	1	Yes	Yes	7	7	1	2
R:R:K192	R:R:S173	9.18	1	Yes	No	6	4	1	1
R:R:F174	R:R:H178	10.18	1	Yes	No	5	4	1	2
R:R:A380	R:R:F174	2.77	0	No	Yes	4	5	2	1
R:R:F174	R:R:M384	2.49	1	Yes	Yes	5	5	1	2
R:R:D176	R:R:K192	2.77	0	No	Yes	3	6	2	1
R:R:F177	R:R:H178	10.18	0	No	No	4	4	1	2
R:R:F189	R:R:L190	2.44	1	Yes	No	9	5	1	2
R:R:F189	R:R:L193	2.44	1	Yes	No	9	4	1	1
R:R:F189	R:R:P269	5.78	1	Yes	No	9	3	1	2
R:R:I271	R:R:L193	4.28	0	No	No	3	4	2	1
R:R:F200	R:R:V196	2.62	0	No	No	7	7	2	1
R:R:A248	R:R:T197	3.36	0	No	No	7	6	2	1
R:R:F268	R:R:I267	2.51	1	Yes	Yes	5	4	1	2
R:R:F379	R:R:I267	7.54	1	Yes	Yes	4	4	2	2
R:R:F268	R:R:I271	2.51	1	Yes	No	5	3	1	2
R:R:F268	R:R:L276	2.44	1	Yes	No	5	5	1	1
R:R:F268	R:R:F379	3.22	1	Yes	Yes	5	4	1	2
R:R:T283	R:R:W279	8.49	0	No	Yes	8	6	2	1
R:R:M363	R:R:W279	3.49	0	No	Yes	6	6	2	1
R:R:F379	R:R:M363	2.49	1	Yes	No	4	6	2	2
R:R:L387	R:R:M384	5.65	0	Yes	Yes	7	5	2	2
R:R:I169	R:R:S173	1.55	0	No	No	5	4	2	1
R:R:L276	R:R:V367	1.49	1	No	No	5	4	1	2
R:R:F191	R:R:K192	1.24	0	No	Yes	5	6	2	1
R:R:T201	R:R:W279	1.21	0	No	Yes	6	6	2	1
R:R:D184	R:R:F189	1.19	0	No	Yes	2	9	2	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	9EGO_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	1.71
Number of Linked Nodes	225
Number of Links	238
Number of Hubs	25
Number of Links mediated by Hubs	100
Number of Communities	9
Number of Nodes involved in Communities	40
Number of Links involved in Communities	48

Path Summary
Number Of Nodes in MetaPath	61
Number Of Links MetaPath	60
Number of Shortest Paths	21667
Length Of Smallest Path	3
Average Path Length	16.1739
Length of Longest Path	45
Minimum Path Strength	1.19
Average Path Strength	4.65335
Maximum Path Strength	14.61
Minimum Path Correlation	0.7
Average Path Correlation	0.924627
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	2.77778
Average % Of Corr. Nodes	45.3717
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	34.6699
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process
Gene Ontology	Cellular Component
SCOP2	Domain Identifier	• G protein-coupled receptor-like • Transducin (heterotrimeric G protein), gamma chain • Ras-like P-loop GTPases
SCOP2	Family Identifier	• G protein-coupled receptor-like • Transducin (heterotrimeric G protein), gamma chain • Ras-like P-loop GTPases
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	YVF
PDB Residues	L:L:?1
Environment Details	Open EMBL-EBI Page
Code	YVF
Name	methyl (2R)-2-({(1M)-5-methyl-1-[3-(trifluoromethyl)phenyl]-1H-pyrazole-3-carbonyl}amino)-2-(thiophen-2-yl)propanoate
Synonyms
Identifier
Formula	C20 H18 F3 N3 O3 S
Molecular Weight	437.435
SMILES
PubChem	170838490
Formal Charge	0
Total Atoms	48
Total Chiral Atoms	1
Total Bonds	50
Total Aromatic Bonds	16


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P21554
Sequence	>9EGO_nogp_Chain_R F M V L N P S Q Q L A I A V L S L T L G T F T V L E N L L V L C V I R C R P S Y H F I G S L A V A D L L G S V I F V Y S F I D F H V F H R K D S R N V F L F K L G G V T A S F T A S V G S L F L T A I D R Y I S I H R P L A Y K R I V T R P K A V V A F C L M W T I A I V I A V L P L L D I F P H I D E T Y L M F W I G V T S V L L L F I V Y A Y M Y I L W K A H S H A V R M I Q R G T A R M D I R L A K T L V L I L V V L I I C W G P L L A I M V Y D V F G K M N K L I K T V F A F C S M L C L L N S T V N P I I Y A L R S K D L R H A F R S M Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	7FEE	A	Lipid	Cannabinoid	CB₁	Homo sapiens	CP55940	ZCZ011	-	2.7	2022-06-15	doi.org/10.1038/s41589-022-01038-y
	7WV9	A	Lipid	Cannabinoid	CB₁	Homo sapiens	CP55940	ZCZ011	Gi2/β1/γ2	3.36	2022-06-15	doi.org/10.1038/s41589-022-01038-y
	7WV9 (No Gprot)	A	Lipid	Cannabinoid	CB₁	Homo sapiens	CP55940	ZCZ011		3.36	2022-06-15	doi.org/10.1038/s41589-022-01038-y
	8IKH	A	Lipid	Cannabinoid	CB₁	Homo sapiens	-	Q2L	Gi1/β1/γ1	3.3	2024-06-05	doi.org/10.1073/pnas.2321532121
	8IKH (No Gprot)	A	Lipid	Cannabinoid	CB₁	Homo sapiens	-	Q2L		3.3	2024-06-05	doi.org/10.1073/pnas.2321532121
	8IKG	A	Lipid	Cannabinoid	CB₁	Homo sapiens	-	Q2B	Gi1/β1/γ1	3.4	2024-06-05	doi.org/10.1073/pnas.2321532121
	8IKG (No Gprot)	A	Lipid	Cannabinoid	CB₁	Homo sapiens	-	Q2B		3.4	2024-06-05	doi.org/10.1073/pnas.2321532121
	6KQI	A	Lipid	Cannabinoid	CB₁	Homo sapiens	CP55940	Org27569	-	3.25	2019-10-23	doi.org/10.1038/s41589-019-0387-2
	8K8J	A	Lipid	Cannabinoid	CB₁	Homo sapiens	Fenofibrate	-	chim(Gs-CtGq)/β1/γ2	2.88	2024-02-14	doi.org/10.1002/advs.202306311
	8K8J (No Gprot)	A	Lipid	Cannabinoid	CB₁	Homo sapiens	Fenofibrate	-		2.88	2024-02-14	doi.org/10.1002/advs.202306311
	5TGZ	A	Lipid	Cannabinoid	CB₁	Homo sapiens	AM6538	-	-	2.8	2016-11-02	doi.org/10.1016/j.cell.2016.10.004
	6N4B	A	Lipid	Cannabinoid	CB₁	Homo sapiens	MDMB-Fubinaca	-	Gi1/β1/γ2	3	2019-01-30	doi.org/10.1016/j.cell.2018.11.040
	6N4B (No Gprot)	A	Lipid	Cannabinoid	CB₁	Homo sapiens	MDMB-Fubinaca	-		3	2019-01-30	doi.org/10.1016/j.cell.2018.11.040
	6KPG	A	Lipid	Cannabinoid	CB₁	Homo sapiens	AM841	-	Gi1/β1/γ2	3	2020-02-12	doi.org/10.1016/j.cell.2020.01.008
	6KPG (No Gprot)	A	Lipid	Cannabinoid	CB₁	Homo sapiens	AM841	-		3	2020-02-12	doi.org/10.1016/j.cell.2020.01.008
	7V3Z	A	Lipid	Cannabinoid	CB₁	Homo sapiens	CP55940	-	-	3.29	2021-11-24	doi.org/10.1021/jacs.1c06847
	5U09	A	Lipid	Cannabinoid	CB₁	Homo sapiens	Taranabant	-	-	2.6	2016-12-07	doi.org/10.1038/nature20613
	5XR8	A	Lipid	Cannabinoid	CB₁	Homo sapiens	AM841	-	-	2.95	2017-07-12	doi.org/10.1038/nature23272
	5XRA	A	Lipid	Cannabinoid	CB₁	Homo sapiens	AM11542	-	-	2.8	2017-07-12	doi.org/10.1038/nature23272
	8GHV	A	Lipid	Cannabinoid	CB₁	Homo sapiens	AMG315	-	Gi1/β1/γ2	2.8	2023-05-24	doi.org/10.1038/s41467-023-37864-4
	8GHV (No Gprot)	A	Lipid	Cannabinoid	CB₁	Homo sapiens	AMG315	-		2.8	2023-05-24	doi.org/10.1038/s41467-023-37864-4
	9B9Z	A	Lipid	Cannabinoid	CB₁	Homo sapiens	A1AKO	-	-	3.3	2024-11-20	doi.org/10.1038/s41467-024-54206-0
	9BA0	A	Lipid	Cannabinoid	CB₁	Homo sapiens	A1AKN	-	-	3.13	2024-11-20	doi.org/10.1038/s41467-024-54206-0
	9B9Y	A	Lipid	Cannabinoid	CB₁	Homo sapiens	7DY	-	-	3.5	2024-11-20	doi.org/10.1038/s41467-024-54206-0
	9B54	A	Lipid	Cannabinoid	CB₁	Homo sapiens	A1AIW	-	Gi1/β1/γ2	2.86	2025-03-05	doi.org/10.1038/s41586-025-08618-7
	9B54 (No Gprot)	A	Lipid	Cannabinoid	CB₁	Homo sapiens	A1AIW	-		2.86	2025-03-05	doi.org/10.1038/s41586-025-08618-7
	9B65	A	Lipid	Cannabinoid	CB₁	Homo sapiens	KCA	-	Gi1/β1/γ2	3.03	2025-03-05	doi.org/10.1038/s41586-025-08618-7
	9B65 (No Gprot)	A	Lipid	Cannabinoid	CB₁	Homo sapiens	KCA	-		3.03	2025-03-05	doi.org/10.1038/s41586-025-08618-7
	8WRZ	A	Lipid	Cannabinoid	CB₁	Homo sapiens	PubChem 102336704	-	Arrestin2	3.6	2024-02-28	doi.org/10.1093/procel/pwad055
	9ERX	A	Lipid	Cannabinoid	CB₁	Homo sapiens	D9-THC analog	-	Gi1/β1/γ2	2.9	2024-06-26	doi.org/10.21203/rs.3.rs-4277209/v1
	9ERX (No Gprot)	A	Lipid	Cannabinoid	CB₁	Homo sapiens	D9-THC analog	-		2.9	2024-06-26	doi.org/10.21203/rs.3.rs-4277209/v1
	8WU1	A	Lipid	Cannabinoid	CB₁	Homo sapiens	PubChem 119025665	-	Arrestin2	3.2	2024-03-20	doi.org/10.1016/j.cell.2023.11.017
	9DGI	A	Lipid	Cannabinoid	CB₁	Homo sapiens	Z8526711350	-	-	3.35	2025-04-30	doi.org/10.1038/s41467-025-57136-7
	9EGO	A	Lipid	Cannabinoid	CB₁	Homo sapiens	YVF	-	Gi1/β1/γ2	3.2	2025-04-30	doi.org/10.1038/s41467-025-57136-7
	9EGO (No Gprot)	A	Lipid	Cannabinoid	CB₁	Homo sapiens	YVF	-		3.2	2025-04-30	doi.org/10.1038/s41467-025-57136-7
	8GAG	A	Lipid	Cannabinoid	CB₁	Homo sapiens	PubChem 170838490	-	Gi1/β1/γ2	3.3	2024-02-28	To be published
	8GAG (No Gprot)	A	Lipid	Cannabinoid	CB₁	Homo sapiens	PubChem 170838490	-		3.3	2024-02-28	To be published

You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download 9EGO_nogp.zip

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