Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


2D representation of the interactions of this orthosteric/allosteric ligand.


Links and nodes colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:F108 R:R:P269 4.33 0 No No 5 3 2 1
R:R:I119 R:R:S123 1.55 6 No Yes 5 7 2 2
R:R:F174 R:R:I119 2.51 6 Yes No 5 5 1 2
R:R:F174 R:R:S123 2.64 6 Yes Yes 5 7 1 2
R:R:F170 R:R:V196 10.49 6 No No 7 7 1 1
R:R:F170 R:R:S383 2.64 6 No No 7 6 1 2
L:L:?1 R:R:F170 12.09 6 Yes No 0 7 0 1
R:R:K192 R:R:S173 3.06 0 No No 6 4 2 1
L:L:?1 R:R:S173 5.32 6 Yes No 0 4 0 1
R:R:F174 R:R:H178 13.58 6 Yes No 5 4 1 2
L:L:?1 R:R:F174 4.32 6 Yes Yes 0 5 0 1
R:R:F177 R:R:H178 5.66 0 No No 4 4 1 2
R:R:F177 R:R:F189 5.36 0 No No 4 9 1 2
L:L:?1 R:R:F177 10.36 6 Yes No 0 4 0 1
R:R:F189 R:R:L193 2.44 0 No No 9 4 2 1
R:R:F189 R:R:P269 10.11 0 No No 9 3 2 1
L:L:?1 R:R:L193 3.92 6 Yes No 0 4 0 1
R:R:F200 R:R:V196 5.24 6 Yes No 7 7 1 1
L:L:?1 R:R:V196 3.17 6 Yes No 0 7 0 1
R:R:T197 R:R:T201 1.57 6 No No 6 6 1 2
R:R:T197 R:R:W279 3.64 6 No Yes 6 6 1 1
L:L:?1 R:R:T197 3.13 6 Yes No 0 6 0 1
R:R:F200 R:R:W279 2 6 Yes Yes 7 6 1 1
R:R:F200 R:R:W356 2 6 Yes Yes 7 8 1 2
R:R:C386 R:R:F200 5.59 6 Yes Yes 7 7 1 1
L:L:?1 R:R:F200 6.04 6 Yes Yes 0 7 0 1
R:R:T201 R:R:W279 4.85 6 No Yes 6 6 2 1
R:R:F268 R:R:S265 5.28 6 Yes No 5 4 1 2
R:R:I271 R:R:S265 7.74 6 Yes No 3 4 2 2
R:R:L276 R:R:S265 1.5 6 Yes No 5 4 2 2
R:R:F268 R:R:I267 6.28 6 Yes No 5 4 1 2
R:R:D366 R:R:I267 15.39 6 Yes No 4 4 2 2
R:R:F268 R:R:I271 2.51 6 Yes Yes 5 3 1 2
R:R:F268 R:R:L276 4.87 6 Yes Yes 5 5 1 2
R:R:F268 R:R:M363 6.22 6 Yes No 5 6 1 1
R:R:D366 R:R:F268 2.39 6 Yes Yes 4 5 2 1
R:R:F268 R:R:F379 2.14 6 Yes No 5 4 1 1
L:L:?1 R:R:F268 10.36 6 Yes Yes 0 5 0 1
L:L:?1 R:R:P269 3.49 6 Yes No 0 3 0 1
R:R:I271 R:R:L276 2.85 6 Yes Yes 3 5 2 2
R:R:D366 R:R:L276 2.71 6 Yes Yes 4 5 2 2
R:R:I280 R:R:W279 2.35 6 Yes Yes 5 6 2 1
R:R:T283 R:R:W279 9.7 6 No Yes 8 6 2 1
R:R:W279 R:R:W356 1.87 6 Yes Yes 6 8 1 2
L:L:?1 R:R:W279 3.23 6 Yes Yes 0 6 0 1
R:R:I280 R:R:T283 1.52 6 Yes No 5 8 2 2
R:R:I280 R:R:M363 4.37 6 Yes No 5 6 2 1
R:R:L359 R:R:W356 4.56 6 Yes Yes 7 8 2 2
R:R:C386 R:R:W356 3.92 6 Yes Yes 7 8 1 2
R:R:F379 R:R:L359 2.44 6 No Yes 4 7 1 2
R:R:C386 R:R:L359 3.17 6 Yes Yes 7 7 1 2
L:L:?1 R:R:M363 2 6 Yes No 0 6 0 1
L:L:?1 R:R:F379 19.86 6 Yes No 0 4 0 1
L:L:?1 R:R:C386 2.25 6 Yes Yes 0 7 0 1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

2D representation of the interactions of this orthosteric/allosteric ligand.


Links and nodes colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:G166 R:R:L165 5.13 9 No Yes 8 6 2 1
R:R:I169 R:R:L165 2.85 9 No Yes 5 6 1 1
R:R:L165 R:R:S199 4.5 9 Yes No 6 7 1 2
R:R:L165 W:W:?1 3.42 9 Yes Yes 6 0 1 0
R:R:G166 R:R:S199 3.71 9 No No 8 7 2 2
R:R:I169 R:R:V168 1.54 9 No No 5 4 1 2
R:R:I169 W:W:?1 11.76 9 No Yes 5 0 1 0
R:R:K192 R:R:S173 3.06 0 No No 6 4 1 2
R:R:F191 W:W:?1 9.03 0 No Yes 5 0 1 0
R:R:K192 W:W:?1 3.48 0 No Yes 6 0 1 0
R:R:G194 R:R:G195 2.11 9 No No 6 4 1 1
R:R:G194 R:R:L252 1.71 9 No No 6 5 1 2
R:R:G194 W:W:?1 8.45 9 No Yes 6 0 1 0
R:R:A198 R:R:G195 1.95 9 No No 5 4 1 1
R:R:G195 W:W:?1 8.45 9 No Yes 4 0 1 0
R:R:A198 R:R:A248 1.79 9 No No 5 7 1 1
R:R:A198 W:W:?1 2.6 9 No Yes 5 0 1 0
R:R:A248 W:W:?1 2.6 9 No Yes 7 0 1 0
R:R:V249 W:W:?1 6.14 0 No Yes 5 0 1 0

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB 7WV9
Class A
SubFamily Lipid
Type Cannabinoid
SubType CB1
Species Homo sapiens
Ligand PubMed 104895
Other Ligand(s) ZCZ011
Protein Partners Gi2/Beta1/Gamma2
PDB Resolution 3.36
Date 2022-06-15
D.O.I. 10.1038/s41589-022-01038-y
Net Summary
Imin 1.5
Number of Linked Nodes 859
Number of Links 1200
Number of Hubs 247
Number of Links mediated by Hubs 827
Number of Communities 18
Number of Nodes involved in Communities 350
Number of Links involved in Communities 575
Path Summary
Number Of Nodes in MetaPath 144
Number Of Links MetaPath 143
Number of Shortest Paths 45796753
Length Of Smallest Path 3
Average Path Length 64
Length of Longest Path 67
Minimum Path Strength 1.41
Average Path Strength 8.00109
Maximum Path Strength 29.32
Minimum Path Correlation 0.7
Average Path Correlation 1
Maximum Path Correlation 1
Minimum % Of Corr. Nodes 2.5641
Average % Of Corr. Nodes 62.3565
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 119.587
Maximum Path Hubs % 100
AnnotationTypeLinks
Gene OntologyMolecular Function
Gene OntologyBiological Process
Gene OntologyCellular Component
SCOP2Domain Identifier
SCOP2Family Identifier
Membrane Protein Annotations-• Orientations of Proteins in Membranes database (OPM)   • Protein Data Bank of Transmembrane Proteins (PDBTM)   • MemProtMD


Details about the values in these tables can be found in the corresponding documentation page .
Code9GF
PDB ResiduesL:L:?1
Environment DetailsOpen EMBL-EBI Page
Code9GF
Name2-[(1R,2R,5R)-5-hydroxy-2-(3-hydroxypropyl)cyclohexyl]-5-(2-methyloctan-2-yl)phenol
Synonyms
Identifier5-(2-methyloctan-2-yl)-2-[(1~{R},2~{R},5~{R})-5-oxidanyl-2-(3-oxidanylpropyl)cyclohexyl]phenol
FormulaC24 H40 O3
Molecular Weight376.573
SMILESCCCCCCC(C)(C)c1ccc(c(c1)O)[C@@H]2C[C@@H](CC[C@H]2CCCO)O
PubChem104895
Formal Charge0
Total Atoms67
Total Chiral Atoms3
Total Bonds68
Total Aromatic Bonds6

Code7IC
PDB ResiduesW:W:?1
Environment DetailsOpen EMBL-EBI Page
Code7IC
Name6-methyl-3-[(1S)-2-nitro-1-thiophen-2-yl-ethyl]-2-phenyl-1H-indole
Synonyms
Identifier6-methyl-3-[(1~{S})-2-nitro-1-thiophen-2-yl-ethyl]-2-phenyl-1~{H}-indole
FormulaC21 H18 N2 O2 S
Molecular Weight362.445
SMILESCc1ccc2c(c1)[nH]c(c2[C@@H](C[N+](=O)[O-])c3cccs3)c4ccccc4
PubChem129407013
Formal Charge0
Total Atoms44
Total Chiral Atoms1
Total Bonds47
Total Aromatic Bonds21

PDBsumOpen PDBsum Page
ChainA
ProteinG Protein α Sub unit
UniProtP04899
Sequence
>7WV9_Chain_A
TVSAEDKAA AERSKMIDK NLREDGEKA AREVKLLLL GAGESGKNT 
IVKQMKTGI VETHFTFKD LHFKMFDVG AQRSERKKW IHCFEGVTA 
IIFCVALSA YDLVLAEDE EMNRMHASM KLFDSICNN KWFTDTSII 
LFLNKKDLF EEKITHSPL TICFPEYTG ANKYDEAAS YIQSKFEDL 
NKRKDTKEI YTHFTCSTD TKNVQFVFD AVTDVIIKN NLKDCGLF


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainB
ProteinG Protein β Sub unit
UniProtP62873
Sequence
>7WV9_Chain_B
ELDQLRQEA EQLKNQIRD ARKACADAT LSQITNNID PVGRIQMRT 
RRTLRGHLA KIYAMHWGT DSRLLVSAS QDGKLIIWD SYTTNKVHA 
IPLRSSWVM TCAYAPSGN YVACGGLDN ICSIYNLKT REGNVRVSR 
ELAGHTGYL SCCRFLDDN QIVTSSGDT TCALWDIET GQQTTTFTG 
HTGDVMSLS LAPDTRLFV SGACDASAK LWDVREGMC RQTFTGHES 
DINAICFFP NGNAFATGS DDATCRLFD LRADQELMT YSHDNIICG 
ITSVSFSKS GRLLLAGYD DFNCNVWDA LKADRAGVL AGHDNRVSC 
LGVTDDGMA VATGSWDSF LKIWN


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainG
ProteinG Protein γ Sub unit
UniProtP59768
Sequence
>7WV9_Chain_G
ASIAQARKL VEQLKMEAN IDRIKVSKA AADLMAYCE AHAKEDPLL 
TPVPASENP FRE


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainR
ProteinReceptor
UniProtP21554
Sequence
>7WV9_Chain_R
ECFMVLNPS QQLAIAVLS LTLGTFTVL ENLLVLCVI LHSRSLRCR 
PSYHFIGSL AVADLLGSV IFVYSFIDF HVFHRKDSR NVFLFKLGG 
VTASFTASV GSLFLTAID RYISIHRPL AYKRIVTRP KAVVAFCLM 
WTIAIVIAV LPLLGWNCE KLQSVCSDI FPHIDETYL MFWIGVTSV 
LLLFIVYAY MYILWKAHS HAVRMIQRG TQKPDQARM DIRLAKTLV 
LILVVLIIC WGPLLAIMV YDVFGKMNK LIKTVFAFC SMLCLLNST 
VNPIIYALR SKDLRHAFR SM


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  



This network is also present in following consensuses:
IdComponents
cb1_on_allo7WV9-CB1-PubMed 104895-ZCZ011-Gi2/&β;1/&γ;2

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
5TGZALipidCannabinoidCB1Homo sapiensAM6538--2.82016-11-0210.1016/j.cell.2016.10.004
5U09ALipidCannabinoidCB1Homo sapiensTaranabant--2.62016-12-0710.1038/nature20613
5XR8ALipidCannabinoidCB1Homo sapiensAM841--2.952017-07-1210.1038/nature23272
5XRAALipidCannabinoidCB1Homo sapiensAM11542--2.82017-07-1210.1038/nature23272
6KPGALipidCannabinoidCB1Homo sapiensAM841-Gi1/&β;1/&γ;232020-02-1210.1016/j.cell.2020.01.008
6KQIALipidCannabinoidCB1Homo sapiensPubMed 104895ORG27569-3.252019-10-2310.1038/s41589-019-0387-2
6N4BALipidCannabinoidCB1Homo sapiensMDMB-Fubinaca-Gi1/&β;1/&γ;232019-01-3010.1016/j.cell.2018.11.040
7FEEALipidCannabinoidCB1Homo sapiensPubMed 104895ZCZ011-2.72022-06-1510.1038/s41589-022-01038-y
7V3ZALipidCannabinoidCB1Homo sapiensPubMed 104895--3.292021-11-2410.1021/jacs.1c06847
8GAGALipidCannabinoidCB1Homo sapiensYVF-Gi1/&β;1/&γ;23.32024-02-28To be published
8GHVALipidCannabinoidCB1Homo sapiensPubChem 145964903-Gi1/&β;1/&γ;22.82023-05-2410.1038/s41467-023-37864-4
8K8JALipidCannabinoidCB1Homo sapiensFenofibrate-chim(Gs-CtGq)/&β;1/&γ;22.882024-02-1410.1002/advs.202306311
8WRZALipidCannabinoidCB1Homo sapiens8D0-Arrestin13.62024-02-2810.1093/procel/pwad055
8WU1ALipidCannabinoidCB1Homo sapiensKCA-Arrestin13.22024-03-20To be published




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