psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:F170	12.09	Yes	No	1	0	7
2	L:L:?1	R:R:S173	5.32	Yes	No	0	0	4
3	L:L:?1	R:R:F174	4.32	Yes	Yes	0	0	5
4	L:L:?1	R:R:F177	10.36	Yes	No	0	0	4
5	L:L:?1	R:R:L193	3.92	Yes	No	0	0	4
6	L:L:?1	R:R:V196	3.17	Yes	No	1	0	7
7	L:L:?1	R:R:T197	3.13	Yes	No	1	0	6
8	L:L:?1	R:R:F200	6.04	Yes	No	1	0	7
9	L:L:?1	R:R:F268	10.36	Yes	Yes	1	0	5
10	L:L:?1	R:R:P269	3.49	Yes	No	0	0	3
11	L:L:?1	R:R:W279	3.23	Yes	Yes	1	0	6
12	L:L:?1	R:R:F379	19.86	Yes	No	0	0	4
13	R:R:E106	R:R:F108	7	No	No	0	4	5
14	R:R:C107	R:R:M109	3.24	No	No	0	2	3
15	R:R:F108	R:R:P269	4.33	No	No	0	5	3
16	R:R:H181	R:R:M109	3.94	No	No	0	3	3
17	R:R:K373	R:R:V110	6.07	No	No	0	3	3
18	R:R:K376	R:R:V110	9.11	No	No	0	2	3
19	R:R:L111	R:R:Q116	15.97	No	No	0	4	4
20	R:R:H178	R:R:L111	5.14	No	No	0	4	4
21	R:R:N112	R:R:P113	6.52	No	No	0	6	2
22	R:R:N112	R:R:Q115	11.88	No	No	0	6	2
23	R:R:P113	R:R:Q116	4.74	No	No	0	2	4
24	R:R:Q116	R:R:V179	5.73	No	No	0	4	4
25	R:R:L117	R:R:V121	2.98	No	No	0	5	4
26	R:R:F174	R:R:I119	2.51	Yes	No	0	5	5
27	R:R:F381	R:R:I119	5.02	No	No	0	4	5
28	R:R:L122	R:R:S123	4.5	No	No	0	5	7
29	R:R:L122	R:R:M384	5.65	No	No	0	5	5
30	R:R:F174	R:R:S123	2.64	Yes	No	0	5	7
31	R:R:L126	R:R:L387	6.92	Yes	No	0	6	7
32	R:R:L126	R:R:L388	2.77	Yes	No	9	6	5
33	R:R:L126	R:R:T391	4.42	Yes	No	9	6	7
34	R:R:G127	R:R:T130	5.46	No	Yes	0	6	7
35	R:R:F129	R:R:T128	2.59	No	No	0	4	5
36	R:R:T130	R:R:V131	3.17	Yes	No	0	7	6
37	R:R:E133	R:R:T130	2.82	Yes	Yes	0	8	7
38	R:R:S167	R:R:T130	9.59	No	Yes	0	7	7
39	R:R:T130	R:R:T391	6.28	Yes	No	0	7	7
40	R:R:E133	R:R:N134	15.77	Yes	Yes	3	8	9
41	R:R:E133	R:R:P394	12.58	Yes	No	3	8	9
42	R:R:D163	R:R:N134	4.04	Yes	Yes	3	9	9
43	R:R:L164	R:R:N134	6.87	No	Yes	0	7	9
44	R:R:N134	R:R:P394	6.52	Yes	No	3	9	9
45	R:R:I141	R:R:V137	3.07	Yes	Yes	0	7	9
46	R:R:A160	R:R:V137	3.39	No	Yes	0	9	9
47	R:R:A398	R:R:V137	3.39	No	Yes	0	7	9
48	R:R:L138	R:R:L142	2.77	No	No	0	7	4
49	R:R:A160	R:R:L138	3.15	No	No	0	9	7
50	R:R:L138	R:R:V161	4.47	No	No	0	7	6
51	R:R:F408	R:R:V140	2.62	No	No	0	7	8
52	R:R:I141	R:R:L142	2.85	Yes	No	0	7	4
53	R:R:I141	R:R:I156	2.94	Yes	No	0	7	8
54	R:R:H143	R:R:R145	9.03	No	Yes	0	5	6
55	R:R:L147	R:R:R145	14.58	Yes	Yes	4	9	6
56	R:R:A407	R:R:R145	2.77	No	Yes	4	7	6
57	R:R:M411	R:R:R145	4.96	No	Yes	0	5	6
58	R:R:L147	R:R:R150	2.43	Yes	Yes	4	9	5
59	R:R:L147	R:R:Y153	7.03	Yes	Yes	4	9	9
60	R:R:A407	R:R:L147	4.73	No	Yes	4	7	9
61	R:R:P151	R:R:R150	2.88	Yes	Yes	0	5	5
62	R:R:R150	R:R:S152	2.64	Yes	No	4	5	8
63	R:R:R150	R:R:Y153	9.26	Yes	Yes	4	5	9
64	R:R:P151	R:R:V228	5.3	Yes	Yes	0	5	6
65	R:R:A233	R:R:P151	3.74	No	Yes	0	7	5
66	R:R:S152	R:R:Y153	5.09	No	Yes	4	8	9
67	R:R:I156	R:R:Y153	2.42	No	Yes	0	8	9
68	R:R:D403	R:R:Y153	5.75	No	Yes	0	6	9
69	R:R:L404	R:R:Y153	21.1	No	Yes	0	8	9
70	R:R:H154	R:R:R230	9.03	No	No	0	3	1
71	R:R:F155	R:R:L209	13.4	No	No	0	8	6
72	R:R:S158	R:R:S206	4.89	No	No	0	9	8
73	R:R:F237	R:R:S158	7.93	No	No	0	8	9
74	R:R:D163	R:R:L159	5.43	Yes	Yes	3	9	9
75	R:R:L159	R:R:S203	3	Yes	No	3	9	9
76	R:R:L159	R:R:S206	3	Yes	No	0	9	8
77	R:R:L159	R:R:L207	4.15	Yes	No	0	9	8
78	R:R:A162	R:R:W241	2.59	No	Yes	0	8	9
79	R:R:D163	R:R:S203	5.89	Yes	No	3	9	9
80	R:R:D163	R:R:S390	11.78	Yes	No	0	9	9
81	R:R:G166	R:R:L165	5.13	No	Yes	5	8	6
82	R:R:I169	R:R:L165	2.85	No	Yes	5	5	6
83	R:R:L165	R:R:S199	4.5	Yes	No	5	6	7
84	R:R:L165	W:W:?1	3.42	Yes	Yes	5	6	0
85	R:R:G166	R:R:S199	3.71	No	No	5	8	7
86	R:R:L387	R:R:S167	3	No	No	0	7	7
87	R:R:I169	W:W:?1	11.76	No	Yes	5	5	0
88	R:R:F170	R:R:V196	10.49	No	No	1	7	7
89	R:R:F170	R:R:S383	2.64	No	No	0	7	6
90	R:R:D176	R:R:Y172	11.49	No	No	0	3	7
91	R:R:K192	R:R:S173	3.06	No	No	0	6	4
92	R:R:F174	R:R:H178	13.58	Yes	No	0	5	4
93	R:R:D176	R:R:R182	7.15	No	No	0	3	4
94	R:R:F177	R:R:H178	5.66	No	No	0	4	4
95	R:R:F177	R:R:F189	5.36	No	No	0	4	9
96	R:R:F180	R:R:V179	3.93	No	No	0	4	4
97	R:R:F180	R:R:R182	12.83	No	No	0	4	4
98	R:R:D184	R:R:V188	5.84	No	No	0	2	5
99	R:R:N187	R:R:S185	2.98	No	No	0	1	7
100	R:R:S185	R:R:V188	4.85	No	No	0	7	5
101	R:R:N187	R:R:R186	4.82	No	Yes	0	1	3
102	R:R:L190	R:R:R186	4.86	No	Yes	0	5	3
103	R:R:N256	R:R:R186	6.03	No	Yes	7	6	3
104	R:R:E258	R:R:R186	6.98	No	Yes	7	1	3
105	R:R:H270	R:R:R186	5.64	Yes	Yes	7	3	3
106	R:R:F189	R:R:L193	2.44	No	No	0	9	4
107	R:R:F189	R:R:P269	10.11	No	No	0	9	3
108	R:R:L190	R:R:L252	5.54	No	No	0	5	5
109	R:R:F191	W:W:?1	9.03	No	Yes	0	5	0
110	R:R:K192	W:W:?1	3.48	No	Yes	0	6	0
111	R:R:G194	W:W:?1	8.45	No	Yes	0	6	0
112	R:R:G195	W:W:?1	8.45	No	Yes	0	4	0
113	R:R:F200	R:R:V196	5.24	No	No	1	7	7
114	R:R:T197	R:R:W279	3.64	No	Yes	1	6	6
115	R:R:A198	W:W:?1	2.6	No	Yes	0	5	0
116	R:R:C386	R:R:F200	5.59	No	No	1	7	7
117	R:R:A244	R:R:T201	3.36	No	No	0	8	6
118	R:R:T201	R:R:W279	4.85	No	Yes	0	6	6
119	R:R:A202	R:R:W241	6.48	No	Yes	0	7	9
120	R:R:L286	R:R:V204	5.96	No	No	0	8	7
121	R:R:G205	R:R:M240	5.24	No	No	0	5	6
122	R:R:I290	R:R:L207	2.85	No	No	0	8	8
123	R:R:L207	R:R:Y397	3.52	No	Yes	0	8	9
124	R:R:F208	R:R:I212	8.79	No	No	0	7	7
125	R:R:F208	R:R:F289	6.43	No	No	0	7	6
126	R:R:T210	R:R:Y397	3.75	No	Yes	0	9	9
127	R:R:A211	R:R:I290	4.87	No	No	0	8	8
128	R:R:D213	R:R:Y224	8.05	No	Yes	10	9	7
129	R:R:D213	R:R:V228	4.38	No	Yes	10	9	6
130	R:R:R214	R:R:Y294	8.23	No	Yes	2	9	9
131	R:R:R214	R:R:Y397	6.17	No	Yes	2	9	9
132	R:R:H219	R:R:Y215	3.27	No	Yes	6	6	8
133	R:R:Y215	R:R:Y292	3.97	Yes	No	0	8	4
134	R:R:A293	R:R:Y215	2.67	No	Yes	0	7	8
135	R:R:Y215	R:R:Y296	12.91	Yes	Yes	6	8	4
136	R:R:S217	R:R:Y224	6.36	No	Yes	0	8	7
137	R:R:I218	R:R:I297	10.3	No	Yes	0	9	9
138	R:R:I218	R:R:K300	2.91	No	No	0	9	5
139	R:R:H219	R:R:R220	10.16	No	No	0	6	5
140	R:R:H219	R:R:Y296	4.36	No	Yes	6	6	4
141	R:R:A223	R:R:R226	5.53	No	No	0	5	4
142	R:R:K225	R:R:Y224	4.78	No	Yes	0	4	7
143	R:R:V228	R:R:Y224	3.79	Yes	Yes	10	6	7
144	R:R:P231	R:R:T229	3.5	No	No	0	4	8
145	R:R:P231	R:R:R230	2.88	No	No	0	4	1
146	R:R:F237	R:R:W241	10.02	No	Yes	0	8	9
147	R:R:I245	R:R:W241	2.35	No	Yes	0	4	9
148	R:R:L250	R:R:V246	8.94	No	No	0	5	3
149	R:R:F278	R:R:I247	3.77	No	No	0	6	5
150	R:R:A248	W:W:?1	2.6	No	Yes	0	7	0
151	R:R:V249	W:W:?1	6.14	No	Yes	0	5	0
152	R:R:P251	R:R:Y275	4.17	No	No	0	6	7
153	R:R:L252	R:R:Y275	2.34	No	No	0	5	7
154	R:R:Q261	R:R:W255	3.29	Yes	No	8	1	5
155	R:R:D272	R:R:W255	11.17	No	No	0	5	5
156	R:R:T274	R:R:W255	7.28	No	No	8	5	5
157	R:R:H270	R:R:N256	3.83	Yes	No	7	3	6
158	R:R:C257	R:R:S262	6.89	No	No	0	9	3
159	R:R:C257	R:R:C264	7.28	No	No	0	9	9
160	R:R:C257	R:R:H270	7.37	No	Yes	0	9	3
161	R:R:E258	R:R:H270	11.08	No	Yes	7	1	3
162	R:R:K259	R:R:L260	7.05	No	No	0	4	3
163	R:R:L260	R:R:Q261	6.65	No	Yes	0	3	1
164	R:R:E273	R:R:Q261	2.55	No	Yes	8	3	1
165	R:R:Q261	R:R:T274	4.25	Yes	No	8	1	5
166	R:R:D272	R:R:S262	8.83	No	No	0	5	3
167	R:R:F268	R:R:S265	5.28	Yes	No	1	5	4
168	R:R:I271	R:R:S265	7.74	Yes	No	1	3	4
169	R:R:D266	R:R:D366	5.32	No	Yes	0	4	4
170	R:R:D266	R:R:M371	12.48	No	No	0	4	1
171	R:R:F268	R:R:I267	6.28	Yes	No	1	5	4
172	R:R:D366	R:R:I267	15.39	Yes	No	1	4	4
173	R:R:I267	R:R:K376	4.36	No	No	0	4	2
174	R:R:F268	R:R:I271	2.51	Yes	Yes	1	5	3
175	R:R:F268	R:R:L276	4.87	Yes	Yes	1	5	5
176	R:R:F268	R:R:M363	6.22	Yes	No	0	5	6
177	R:R:D366	R:R:F268	2.39	Yes	Yes	1	4	5
178	R:R:I271	R:R:Y275	4.84	Yes	No	0	3	7
179	R:R:I271	R:R:L276	2.85	Yes	Yes	1	3	5
180	R:R:E273	R:R:T274	8.47	No	No	8	3	5
181	R:R:D366	R:R:L276	2.71	Yes	Yes	1	4	5
182	R:R:I280	R:R:W279	2.35	Yes	Yes	0	5	6
183	R:R:T283	R:R:W279	9.7	No	Yes	0	8	6
184	R:R:I280	R:R:L360	4.28	Yes	No	0	5	7
185	R:R:I280	R:R:M363	4.37	Yes	No	0	5	6
186	R:R:G281	R:R:S284	3.71	No	No	0	3	5
187	R:R:L286	R:R:V282	2.98	No	No	0	8	6
188	R:R:F289	R:R:V285	5.24	No	No	0	6	6
189	R:R:L287	R:R:L352	4.15	No	No	0	6	9
190	R:R:L287	R:R:W356	3.42	No	Yes	0	6	8
191	R:R:I290	R:R:Y294	2.42	No	Yes	0	8	9
192	R:R:L349	R:R:V291	4.47	No	No	0	8	5
193	R:R:I297	R:R:Y294	2.42	Yes	Yes	2	9	9
194	R:R:I348	R:R:Y294	4.84	No	Yes	2	8	9
195	R:R:L349	R:R:Y294	3.52	No	Yes	0	8	9
196	R:R:Y294	R:R:Y397	4.96	Yes	Yes	2	9	9
197	R:R:W299	R:R:Y296	10.61	No	Yes	6	3	4
198	R:R:K300	R:R:Y296	7.17	No	Yes	6	5	4
199	R:R:I297	R:R:L298	2.85	Yes	Yes	2	9	6
200	R:R:I297	R:R:L345	2.85	Yes	No	2	9	8
201	R:R:L298	R:R:L345	4.15	Yes	No	2	6	8
202	R:R:K300	R:R:W299	9.28	No	No	6	5	3
203	R:R:S303	R:R:W299	7.41	No	No	0	5	3
204	R:R:H302	R:R:V306	6.92	No	No	0	5	5
205	R:R:D338	R:R:H302	10.08	No	No	0	7	5
206	R:R:H304	R:R:M308	2.63	No	No	0	7	7
207	R:R:H304	R:R:M337	3.94	No	No	0	7	6
208	R:R:Q310	R:R:V306	5.73	No	No	0	4	5
209	R:R:M308	R:R:T313	6.02	No	No	0	7	3
210	R:R:P332	R:R:R336	10.09	No	No	0	2	4
211	R:R:D333	R:R:Q334	5.22	No	No	0	3	5
212	R:R:K343	R:R:R400	3.71	No	No	0	7	7
213	R:R:L345	R:R:T344	5.9	No	No	0	8	8
214	R:R:R400	R:R:T344	15.52	No	No	0	7	8
215	R:R:L347	R:R:V351	2.98	No	No	0	7	6
216	R:R:I396	R:R:L347	2.85	No	No	0	9	7
217	R:R:I348	R:R:I396	2.94	No	No	0	8	9
218	R:R:I348	R:R:Y397	2.42	No	Yes	2	8	9
219	R:R:C355	R:R:N389	11.02	No	No	0	8	9
220	R:R:L359	R:R:W356	4.56	Yes	Yes	1	7	8
221	R:R:L360	R:R:W356	5.69	No	Yes	0	7	8
222	R:R:C386	R:R:W356	3.92	No	Yes	1	7	8
223	R:R:N389	R:R:W356	6.78	No	Yes	0	9	8
224	R:R:G357	R:R:P358	4.06	No	No	0	5	9
225	R:R:C382	R:R:P358	3.77	No	No	0	5	9
226	R:R:L385	R:R:P358	3.28	No	No	0	7	9
227	R:R:F379	R:R:L359	2.44	No	Yes	0	4	7
228	R:R:C382	R:R:L359	3.17	No	Yes	0	5	7
229	R:R:C386	R:R:L359	3.17	No	Yes	1	7	7
230	R:R:C382	R:R:I362	3.27	No	No	0	5	4
231	R:R:K370	R:R:Y365	7.17	No	No	0	1	4
232	R:R:K370	R:R:N372	2.8	No	No	0	1	1
233	R:R:I375	R:R:M371	2.92	No	No	0	3	1
234	R:R:I375	R:R:N372	7.08	No	No	0	3	1
235	R:R:L374	R:R:T377	2.95	No	No	0	4	1
236	R:R:I375	R:R:K376	7.27	No	No	0	3	2
237	R:R:F381	R:R:T377	3.89	No	No	0	4	1
238	R:R:L388	R:R:T391	4.42	No	No	9	5	7
239	R:R:N389	R:R:N393	10.9	No	No	0	9	9
240	R:R:N393	R:R:Y397	2.33	No	Yes	0	9	9
241	R:R:L404	R:R:S401	9.01	No	No	0	8	8
242	R:R:H406	R:R:S410	5.58	No	No	0	4	3
243	R:R:H154	R:R:R148	2.26	No	No	0	3	8
244	R:R:R307	R:R:R311	2.13	No	No	0	4	5
245	R:R:F368	R:R:Y365	2.06	No	No	0	5	4
246	R:R:A160	R:R:G157	1.95	No	No	0	9	6
247	R:R:A305	R:R:A335	1.79	No	No	0	5	4
248	R:R:P394	R:R:V137	1.77	No	Yes	0	9	9
249	R:R:G281	R:R:I280	1.76	No	Yes	0	3	5
250	R:R:G369	R:R:M371	1.75	No	No	0	3	1
251	R:R:C149	R:R:S146	1.72	No	No	0	7	5
252	R:R:C238	R:R:V234	1.71	No	No	0	4	1
253	R:R:G254	R:R:L253	1.71	No	No	0	5	5
254	R:R:A120	R:R:V179	1.7	No	No	0	5	4
255	R:R:G254	R:R:N256	1.7	No	No	0	5	6
256	R:R:I247	R:R:P251	1.69	No	No	0	5	6
257	R:R:L250	R:R:P251	1.64	No	No	0	5	6
258	R:R:C355	R:R:I354	1.64	No	No	0	8	5
259	R:R:S123	R:R:V171	1.62	No	No	0	7	7
260	R:R:A223	R:R:I227	1.62	No	No	0	5	4
261	R:R:S284	R:R:V285	1.62	No	No	0	5	6
262	R:R:A301	R:R:M337	1.61	No	No	0	8	6
263	R:R:V131	R:R:V168	1.6	No	No	0	6	4
264	R:R:V234	R:R:V235	1.6	No	No	0	1	3
265	R:R:V346	R:R:V350	1.6	No	No	0	6	6
266	R:R:V351	R:R:V392	1.6	No	No	0	6	6
267	R:R:T377	R:R:V378	1.59	No	No	0	1	4
268	R:R:A342	R:R:L298	1.58	No	Yes	0	7	6
269	R:R:A301	R:R:L341	1.58	No	No	0	8	8
270	R:R:A398	R:R:L399	1.58	No	No	0	7	5
271	R:R:T125	R:R:T128	1.57	No	No	0	4	5
272	R:R:I141	R:R:V140	1.54	Yes	No	0	7	8
273	R:R:I175	R:R:V171	1.54	No	No	0	5	7
274	R:R:I216	R:R:V228	1.54	No	Yes	0	5	6
275	R:R:I227	R:R:V228	1.54	No	Yes	0	4	6
276	R:R:I280	R:R:V364	1.54	Yes	No	0	5	6
277	R:R:A301	R:R:D338	1.54	No	No	0	8	7
278	R:R:A305	R:R:D338	1.54	No	No	0	5	7
279	R:R:I243	R:R:T242	1.52	No	No	0	5	4
280	R:R:M295	R:R:V291	1.52	No	No	0	3	5
281	R:R:F208	R:R:G205	1.51	No	No	0	7	5
282	R:R:L147	R:R:S146	1.5	Yes	No	0	9	5
283	R:R:N112	R:R:S114	1.49	No	No	0	6	5
284	R:R:L287	R:R:V204	1.49	No	No	0	6	7
285	R:R:L276	R:R:V367	1.49	Yes	No	0	5	4
286	R:R:L122	R:R:T125	1.47	No	No	0	5	4
287	R:R:L124	R:R:T128	1.47	No	No	0	3	5
288	R:R:L126	R:R:T125	1.47	Yes	No	0	6	4
289	R:R:L239	R:R:T242	1.47	No	No	0	3	4
290	R:R:D266	R:R:V263	1.46	No	No	0	4	4
291	R:R:F155	R:R:P151	1.44	No	Yes	0	8	5
292	R:R:P221	R:R:R220	1.44	No	No	0	8	5
293	R:R:L135	R:R:L164	1.38	No	No	0	3	7
294	R:R:L298	R:R:L341	1.38	Yes	No	0	6	8
295	R:R:E133	R:R:I395	1.37	Yes	No	0	8	6
296	R:R:H181	R:R:L111	1.29	No	No	0	3	4
297	R:R:K402	R:R:R340	1.24	No	No	0	5	7
298	R:R:Q310	R:R:R307	1.17	No	No	0	4	4
299	R:R:R336	R:R:R340	1.07	No	No	0	4	7

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	L:L:?1	7.1075	12	1	0
2	R:R:L126	3.895	4	9	6
3	R:R:T130	5.464	5	0	7
4	R:R:E133	8.135	4	3	8
5	R:R:N134	8.3	4	3	9
6	R:R:V137	2.905	4	0	9
7	R:R:I141	2.6	4	0	7
8	R:R:R145	7.835	4	4	6
9	R:R:L147	6.054	5	4	9
10	R:R:R150	4.3025	4	4	5
11	R:R:P151	3.34	4	0	5
12	R:R:Y153	8.44167	6	4	9
13	R:R:L159	3.895	4	3	9
14	R:R:D163	6.785	4	3	9
15	R:R:L165	3.975	4	5	6
16	R:R:F174	5.7625	4	0	5
17	R:R:R186	5.666	5	7	3
18	R:R:Y215	5.705	4	6	8
19	R:R:Y224	5.745	4	10	7
20	R:R:V228	3.31	5	10	6
21	R:R:W241	5.36	4	0	9
22	R:R:Q261	4.185	4	8	1
23	R:R:F268	5.41571	7	1	5
24	R:R:H270	6.98	4	7	3
25	R:R:I271	4.485	4	1	3
26	R:R:L276	2.98	4	1	5
27	R:R:W279	4.754	5	1	6
28	R:R:I280	2.86	5	0	5
29	R:R:Y294	4.39833	6	2	9
30	R:R:Y296	8.7625	4	6	4
31	R:R:I297	4.605	4	2	9
32	R:R:L298	2.49	4	2	6
33	R:R:W356	4.874	5	1	8
34	R:R:L359	3.335	4	1	7
35	R:R:D366	6.4525	4	1	4
36	R:R:Y397	3.85833	6	2	9
37	W:W:?1	6.21444	9	5	0

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:F174	52.7149	4.32	Yes	Yes	0	0	5
2	R:R:F174	R:R:H178	23.5311	13.58	Yes	No	0	5	4
3	R:R:H178	R:R:L111	38.4076	5.14	No	No	0	4	4
4	L:L:?1	R:R:F177	20.1878	10.36	Yes	No	0	0	4
5	R:R:F177	R:R:H178	18.5991	5.66	No	No	0	4	4
6	L:L:?1	R:R:F268	63.717	10.36	Yes	Yes	1	0	5
7	R:R:F268	R:R:I267	16.854	6.28	Yes	No	1	5	4
8	R:R:I267	R:R:K376	15.1705	4.36	No	No	0	4	2
9	R:R:L111	R:R:Q116	28.3729	15.97	No	No	0	4	4
10	R:R:P113	R:R:Q116	10.4472	4.74	No	No	0	2	4
11	R:R:Q116	R:R:V179	15.6163	5.73	No	No	0	4	4
12	R:R:F174	R:R:S123	35.9605	2.64	Yes	No	0	5	7
13	R:R:L122	R:R:S123	33.5278	4.5	No	No	0	5	7
14	R:R:L122	R:R:T125	31.9818	1.47	No	No	0	5	4
15	R:R:L126	R:R:T125	31.9628	1.47	Yes	No	0	6	4
16	R:R:L126	R:R:T391	29.8335	4.42	Yes	No	9	6	7
17	R:R:T130	R:R:T391	30.5354	6.28	Yes	No	0	7	7
18	R:R:E133	R:R:T130	32.1667	2.82	Yes	Yes	0	8	7
19	R:R:E133	R:R:P394	22.8529	12.58	Yes	No	3	8	9
20	L:L:?1	R:R:F200	39.5457	6.04	Yes	No	1	0	7
21	R:R:C386	R:R:F200	40.3566	5.59	No	No	1	7	7
22	R:R:C386	R:R:W356	40.2428	3.92	No	Yes	1	7	8
23	R:R:N389	R:R:W356	100	6.78	No	Yes	0	9	8
24	R:R:N389	R:R:N393	96.927	10.9	No	No	0	9	9
25	R:R:N393	R:R:Y397	95.9169	2.33	No	Yes	0	9	9
26	R:R:L207	R:R:Y397	41.0253	3.52	No	Yes	0	8	9
27	R:R:L159	R:R:L207	48.8974	4.15	Yes	No	0	9	8
28	R:R:D163	R:R:L159	34.5948	5.43	Yes	Yes	3	9	9
29	L:L:?1	R:R:F379	42.5807	19.86	Yes	No	0	0	4
30	R:R:F379	R:R:L359	42.3389	2.44	No	Yes	0	4	7
31	R:R:L359	R:R:W356	42.135	4.56	Yes	Yes	1	7	8
32	R:R:P394	R:R:V137	45.3882	1.77	No	Yes	0	9	9
33	R:R:I141	R:R:V137	37.682	3.07	Yes	Yes	0	7	9
34	R:R:I141	R:R:I156	33.5467	2.94	Yes	No	0	7	8
35	R:R:I156	R:R:Y153	32.4133	2.42	No	Yes	0	8	9
36	R:R:R150	R:R:Y153	17.8356	9.26	Yes	Yes	4	5	9
37	R:R:P151	R:R:R150	17.1006	2.88	Yes	Yes	0	5	5
38	R:R:P151	R:R:V228	11.9789	5.3	Yes	Yes	0	5	6
39	R:R:L159	R:R:S206	15.1989	3	Yes	No	0	9	8
40	R:R:S158	R:R:S206	13.0554	4.89	No	No	0	9	8
41	R:R:F237	R:R:S158	10.9025	7.93	No	No	0	8	9
42	L:L:?1	R:R:S173	19.927	5.32	Yes	No	0	0	4
43	R:R:K192	R:R:S173	18.547	3.06	No	No	0	6	4
44	R:R:K192	W:W:?1	17.0484	3.48	No	Yes	0	6	0
45	R:R:F180	R:R:V179	10.4472	3.93	No	No	0	4	4
46	R:R:F268	R:R:I271	53.4879	2.51	Yes	Yes	1	5	3
47	R:R:I271	R:R:Y275	52.9426	4.84	Yes	No	0	3	7
48	R:R:L252	R:R:Y275	42.6424	2.34	No	No	0	5	7
49	R:R:L190	R:R:L252	40.8925	5.54	No	No	0	5	5
50	R:R:L190	R:R:R186	39.1331	4.86	No	Yes	0	5	3
51	R:R:H270	R:R:R186	22.6443	5.64	Yes	Yes	7	3	3
52	R:R:L287	R:R:W356	10.4519	3.42	No	Yes	0	6	8
53	R:R:I290	R:R:L207	15.4313	2.85	No	No	0	8	8
54	R:R:Y294	R:R:Y397	69.3128	4.96	Yes	Yes	2	9	9
55	R:R:I290	R:R:Y294	15.1563	2.42	No	Yes	0	8	9
56	R:R:I297	R:R:Y294	71.3046	2.42	Yes	Yes	2	9	9
57	R:R:I218	R:R:I297	25.6604	10.3	No	Yes	0	9	9
58	R:R:I218	R:R:K300	23.3698	2.91	No	No	0	9	5
59	R:R:K300	R:R:Y296	16.3892	7.17	No	Yes	6	5	4
60	R:R:C257	R:R:H270	21.0177	7.37	No	Yes	0	9	3
61	R:R:C257	R:R:S262	17.2808	6.89	No	No	0	9	3
62	R:R:D272	R:R:S262	15.3981	8.83	No	No	0	5	3
63	R:R:D272	R:R:W255	13.506	11.17	No	No	0	5	5
64	R:R:I280	R:R:L360	24.6076	4.28	Yes	No	0	5	7
65	R:R:I297	R:R:L298	36.4822	2.85	Yes	Yes	2	9	6
66	R:R:L298	R:R:L341	32.2853	1.38	Yes	No	0	6	8
67	R:R:A301	R:R:L341	30.1845	1.58	No	No	0	8	8
68	R:R:A301	R:R:D338	18.7651	1.54	No	No	0	8	7
69	R:R:D338	R:R:H302	11.7987	10.08	No	No	0	7	5
70	R:R:D163	R:R:N134	32.7168	4.04	Yes	Yes	3	9	9
71	R:R:L360	R:R:W356	24.527	5.69	No	Yes	0	7	8
72	R:R:I280	R:R:M363	19.0591	4.37	Yes	No	0	5	6
73	R:R:N134	R:R:P394	23.5501	6.52	Yes	No	3	9	9
74	R:R:F268	R:R:M363	19.1777	6.22	Yes	No	0	5	6

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:?1	R:R:F170	12.09	1	Yes	No	0	7	0	1
L:L:?1	R:R:S173	5.32	1	Yes	No	0	4	0	1
L:L:?1	R:R:F174	4.32	1	Yes	Yes	0	5	0	1
L:L:?1	R:R:F177	10.36	1	Yes	No	0	4	0	1
L:L:?1	R:R:L193	3.92	1	Yes	No	0	4	0	1
L:L:?1	R:R:V196	3.17	1	Yes	No	0	7	0	1
L:L:?1	R:R:T197	3.13	1	Yes	No	0	6	0	1
L:L:?1	R:R:F200	6.04	1	Yes	No	0	7	0	1
L:L:?1	R:R:F268	10.36	1	Yes	Yes	0	5	0	1
L:L:?1	R:R:P269	3.49	1	Yes	No	0	3	0	1
L:L:?1	R:R:W279	3.23	1	Yes	Yes	0	6	0	1
L:L:?1	R:R:F379	19.86	1	Yes	No	0	4	0	1
R:R:F108	R:R:P269	4.33	0	No	No	5	3	2	1
R:R:F174	R:R:I119	2.51	0	Yes	No	5	5	1	2
R:R:F174	R:R:S123	2.64	0	Yes	No	5	7	1	2
R:R:F170	R:R:V196	10.49	1	No	No	7	7	1	1
R:R:F170	R:R:S383	2.64	1	No	No	7	6	1	2
R:R:K192	R:R:S173	3.06	0	No	No	6	4	2	1
R:R:F174	R:R:H178	13.58	0	Yes	No	5	4	1	2
R:R:F177	R:R:H178	5.66	0	No	No	4	4	1	2
R:R:F177	R:R:F189	5.36	0	No	No	4	9	1	2
R:R:F189	R:R:L193	2.44	0	No	No	9	4	2	1
R:R:F189	R:R:P269	10.11	0	No	No	9	3	2	1
R:R:F200	R:R:V196	5.24	1	No	No	7	7	1	1
R:R:T197	R:R:W279	3.64	1	No	Yes	6	6	1	1
R:R:C386	R:R:F200	5.59	1	No	No	7	7	2	1
R:R:T201	R:R:W279	4.85	0	No	Yes	6	6	2	1
R:R:F268	R:R:S265	5.28	1	Yes	No	5	4	1	2
R:R:I271	R:R:S265	7.74	1	Yes	No	3	4	2	2
R:R:F268	R:R:I267	6.28	1	Yes	No	5	4	1	2
R:R:D366	R:R:I267	15.39	1	Yes	No	4	4	2	2
R:R:F268	R:R:I271	2.51	1	Yes	Yes	5	3	1	2
R:R:F268	R:R:L276	4.87	1	Yes	Yes	5	5	1	2
R:R:F268	R:R:M363	6.22	1	Yes	No	5	6	1	2
R:R:D366	R:R:F268	2.39	1	Yes	Yes	4	5	2	1
R:R:I271	R:R:L276	2.85	1	Yes	Yes	3	5	2	2
R:R:D366	R:R:L276	2.71	1	Yes	Yes	4	5	2	2
R:R:I280	R:R:W279	2.35	0	Yes	Yes	5	6	2	1
R:R:T283	R:R:W279	9.7	0	No	Yes	8	6	2	1
R:R:I280	R:R:M363	4.37	0	Yes	No	5	6	2	2
R:R:F379	R:R:L359	2.44	0	No	Yes	4	7	1	2
R:R:C386	R:R:L359	3.17	1	No	Yes	7	7	2	2

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:G166	R:R:L165	5.13	5	No	Yes	8	6	2	1
R:R:I169	R:R:L165	2.85	5	No	Yes	5	6	1	1
R:R:L165	R:R:S199	4.5	5	Yes	No	6	7	1	2
R:R:L165	W:W:?1	3.42	5	Yes	Yes	6	0	1	0
R:R:G166	R:R:S199	3.71	5	No	No	8	7	2	2
R:R:I169	W:W:?1	11.76	5	No	Yes	5	0	1	0
R:R:K192	R:R:S173	3.06	0	No	No	6	4	1	2
R:R:F191	W:W:?1	9.03	0	No	Yes	5	0	1	0
R:R:K192	W:W:?1	3.48	0	No	Yes	6	0	1	0
R:R:G194	W:W:?1	8.45	0	No	Yes	6	0	1	0
R:R:G195	W:W:?1	8.45	0	No	Yes	4	0	1	0
R:R:A198	W:W:?1	2.6	0	No	Yes	5	0	1	0
R:R:A248	W:W:?1	2.6	0	No	Yes	7	0	1	0
R:R:V249	W:W:?1	6.14	0	No	Yes	5	0	1	0

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	7WV9_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	2.33
Number of Linked Nodes	271
Number of Links	299
Number of Hubs	37
Number of Links mediated by Hubs	149
Number of Communities	10
Number of Nodes involved in Communities	58
Number of Links involved in Communities	74

Path Summary
Number Of Nodes in MetaPath	75
Number Of Links MetaPath	74
Number of Shortest Paths	48331
Length Of Smallest Path	3
Average Path Length	14.1593
Length of Longest Path	34
Minimum Path Strength	1.155
Average Path Strength	5.28944
Maximum Path Strength	15.18
Minimum Path Correlation	0.7
Average Path Correlation	0.933983
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	4.54545
Average % Of Corr. Nodes	52.589
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	41.8353
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function	• binding • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • protein-containing complex binding • G-protein beta/gamma-subunit complex binding • protein binding • signaling receptor binding • G protein-coupled receptor binding • cation binding • metal ion binding • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • regulation of biological process • cell population proliferation • regulation of cellular process • positive regulation of cell population proliferation • biological regulation • positive regulation of biological process • positive regulation of neural precursor cell proliferation • regulation of cell population proliferation • cellular process • neural precursor cell proliferation • positive regulation of cellular process • regulation of neural precursor cell proliferation • reactive oxygen species metabolic process • regulation of superoxide metabolic process
Gene Ontology	Biological Process	• regulation of biological process • cell population proliferation • regulation of cellular process • positive regulation of cell population proliferation • biological regulation • positive regulation of biological process • positive regulation of neural precursor cell proliferation • regulation of cell population proliferation • cellular process • neural precursor cell proliferation • positive regulation of cellular process • regulation of neural precursor cell proliferation • reactive oxygen species metabolic process • regulation of superoxide metabolic process • positive regulation of reactive oxygen species metabolic process • superoxide metabolic process • positive regulation of metabolic process • superoxide anion generation • metabolic process • positive regulation of superoxide anion generation • regulation of superoxide anion generation • regulation of metabolic process • regulation of reactive oxygen species metabolic process • regulation of calcium ion transport • regulation of localization • transport • regulation of transport • regulation of monoatomic ion transport • establishment of localization • metal ion transport • calcium ion transport • localization • monoatomic ion transport • regulation of metal ion transport • monoatomic cation transport • cellular response to stimulus • positive regulation of cell communication • positive regulation of signal transduction • response to stimulus • signaling • regulation of signal transduction • intracellular signal transduction • cell communication • positive regulation of response to stimulus • positive regulation of ERK1 and ERK2 cascade • regulation of intracellular signal transduction • intracellular signaling cassette • signal transduction • regulation of signaling • positive regulation of MAPK cascade • positive regulation of intracellular signal transduction • regulation of MAPK cascade • regulation of response to stimulus • MAPK cascade • regulation of cell communication • ERK1 and ERK2 cascade • regulation of ERK1 and ERK2 cascade • positive regulation of signaling • negative regulation of signaling • negative regulation of biological process • negative regulation of G protein-coupled receptor signaling pathway • negative regulation of cell communication • negative regulation of adenylate cyclase-activating adrenergic receptor signaling pathway • adrenergic receptor signaling pathway • negative regulation of cellular process • regulation of G protein-coupled receptor signaling pathway • adenylate cyclase-activating adrenergic receptor signaling pathway • negative regulation of response to stimulus • adenylate cyclase-activating G protein-coupled receptor signaling pathway • negative regulation of signal transduction • negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway • cell division • regulation of body fluid levels • multicellular organismal process • renal system process • system process • positive regulation of urine volume • regulation of urine volume • regulation of biological quality • regulation of vascular associated smooth muscle cell proliferation • positive regulation of vascular associated smooth muscle cell proliferation • regulation of smooth muscle cell proliferation • smooth muscle cell proliferation • positive regulation of smooth muscle cell proliferation • muscle cell proliferation • vascular associated smooth muscle cell proliferation • cell-cell signaling • gamma-aminobutyric acid signaling pathway • purinergic nucleotide receptor signaling pathway • cell surface receptor signaling pathway • G protein-coupled purinergic receptor signaling pathway • G protein-coupled adenosine receptor signaling pathway • regulation of molecular function • negative regulation of lyase activity • regulation of adenylate cyclase activity • regulation of catalytic activity • negative regulation of molecular function • negative regulation of catalytic activity • negative regulation of adenylate cyclase activity • regulated exocytosis • regulation of calcium ion-dependent exocytosis • negative regulation of transport • negative regulation of regulated secretory pathway • vesicle-mediated transport • regulation of regulated secretory pathway • secretion by cell • regulation of secretion by cell • negative regulation of secretion • negative regulation of exocytosis • negative regulation of secretion by cell • calcium-ion regulated exocytosis • secretion • negative regulation of calcium ion-dependent exocytosis • export from cell • regulation of vesicle-mediated transport • regulation of secretion • exocytosis • regulation of exocytosis • regulation of programmed cell death • negative regulation of apoptotic signaling pathway • negative regulation of programmed cell death • regulation of apoptotic process • cell death • apoptotic signaling pathway • negative regulation of apoptotic process • apoptotic process • programmed cell death • regulation of apoptotic signaling pathway • positive regulation of locomotion • regulation of cell motility • positive regulation of cell migration • regulation of locomotion • positive regulation of cell motility • regulation of cell migration • cell migration • cell motility • locomotion • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • trans-synaptic signaling • modulation of chemical synaptic transmission • negative regulation of synaptic transmission • chemical synaptic transmission • synaptic signaling • regulation of trans-synaptic signaling • anterograde trans-synaptic signaling • cellular response to nitrogen compound • cellular response to acetylcholine • response to oxygen-containing compound • response to nitrogen compound • acetylcholine receptor signaling pathway • postsynaptic signal transduction • cellular response to oxygen-containing compound • cellular response to chemical stimulus • G protein-coupled acetylcholine receptor signaling pathway • response to chemical • response to acetylcholine • response to nutrient levels • response to nutrient • midbody • cellular anatomical structure • membrane • membrane-bounded organelle • intracellular anatomical structure • dense core granule • intracellular vesicle • intracellular membrane-bounded organelle • endomembrane system • intracellular organelle • cytoplasmic vesicle • organelle • secretory granule • secretory vesicle
Gene Ontology	Cellular Component	• midbody • cellular anatomical structure • membrane • membrane-bounded organelle • intracellular anatomical structure • dense core granule • intracellular vesicle • intracellular membrane-bounded organelle • endomembrane system • intracellular organelle • cytoplasmic vesicle • organelle • secretory granule • secretory vesicle • cytoplasm • vesicle • neuronal dense core vesicle • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cell periphery • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • extracellular vesicle • extracellular organelle • extracellular region • extracellular space • extracellular membrane-bounded organelle • centrosome • microtubule organizing center • cytoskeleton • membraneless organelle • intracellular membraneless organelle • microtubule cytoskeleton • cytosol • somatodendritic compartment • cell projection • dendrite • dendritic tree • neuron projection • plasma membrane bounded cell projection • nucleus • membrane-enclosed lumen • intracellular organelle lumen • nucleoplasm • organelle lumen • nuclear lumen • neuron to neuron synapse • synapse • cell junction • hippocampal mossy fiber to CA3 synapse • cell body • cilium • ciliary basal body • protein binding • binding • enzyme binding • GTPase binding • protein-containing complex binding • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • multicellular organismal process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development • anatomical structure development • sensory system development • system development • cell population proliferation • cellular process • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • signal transduction • cell communication • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • response to oxygen-containing compound • cellular response to oxygen-containing compound • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to chemical stimulus • cellular response to alcohol • response to hormone • response to chemical • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • small GTPase-mediated signal transduction • Ras protein signal transduction • intracellular signal transduction • intracellular signaling cassette • phospholipase C-activating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular response to nitrogen compound • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • response to nitrogen compound • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to monoamine stimulus • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • synaptic signaling • cellular response to acetylcholine • cell-cell signaling • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • non-motile cilium • 9+0 non-motile cilium • photoreceptor disc membrane • photoreceptor outer segment • photoreceptor cell cilium • organelle membrane • vacuolar membrane • lytic vacuole • vacuole • lytic vacuole membrane • bounding membrane of organelle • lysosomal membrane • lysosome • G-protein beta-subunit binding • fibroblast proliferation • identical protein binding • molecular transducer activity • G protein-coupled receptor activity • transmembrane signaling receptor activity • signaling receptor activity • cannabinoid receptor activity • spermatogenesis • sexual reproduction • reproductive process • multicellular organismal reproductive process • developmental process involved in reproduction • male gamete generation • gamete generation • regulation of penile erection • regulation of reproductive process • mating behavior • behavior • reproductive behavior • regulation of multicellular organismal process • penile erection • copulation • positive regulation of programmed cell death • regulation of apoptotic process • positive regulation of biological process • regulation of programmed cell death • cell death • positive regulation of apoptotic process • apoptotic process • programmed cell death • positive regulation of cellular process • learning or memory • cognition • memory • monoamine transport • regulation of localization • nitrogen compound transport • negative regulation of amine transport • regulation of catecholamine secretion • transport • negative regulation of biological process • negative regulation of transport • organic hydroxy compound transport • dopamine transport • localization • secretion by cell • regulation of secretion by cell • negative regulation of secretion • catecholamine transport • negative regulation of dopamine secretion • signal release • negative regulation of cellular process • negative regulation of secretion by cell • secretion • regulation of transport • export from cell • negative regulation of catecholamine secretion • dopamine secretion • establishment of localization • regulation of secretion • catecholamine secretion • amine transport • regulation of amine transport • regulation of dopamine secretion • regulation of neuron projection development • regulation of cellular component organization • positive regulation of cellular component organization • cellular developmental process • cell projection organization • cell development • neuron projection development • cellular component organization • neurogenesis • neuron differentiation • positive regulation of neuron projection development • cell differentiation • positive regulation of cell projection organization • cellular component organization or biogenesis • plasma membrane bounded cell projection organization • regulation of cell projection organization • nervous system development • generation of neurons • neuron development • regulation of plasma membrane bounded cell projection organization • metabolic process • regulation of metabolic process • protein localization • establishment of protein localization • cellular macromolecule localization • regulation of biological quality • regulation of peptide hormone secretion • regulation of hormone levels • establishment of protein localization to extracellular region • protein secretion • regulation of protein secretion • cellular localization • regulation of hormone secretion • regulation of protein localization • regulation of peptide secretion • hormone secretion • protein localization to extracellular region • peptide secretion • amide transport • regulation of signaling • regulation of peptide transport • regulation of establishment of protein localization • regulation of protein transport • peptide transport • protein transport • regulation of cellular localization • regulation of insulin secretion • peptide hormone secretion • macromolecule localization • hormone transport • regulation of cell communication • insulin secretion • positive regulation of acute inflammatory response to antigenic stimulus • regulation of defense response • regulation of acute inflammatory response to antigenic stimulus • regulation of response to external stimulus • positive regulation of acute inflammatory response • inflammatory response to antigenic stimulus • positive regulation of response to stimulus • positive regulation of response to external stimulus • positive regulation of inflammatory response • positive regulation of immune response • response to stress • regulation of response to stress • regulation of immune system process • acute inflammatory response • positive regulation of immune system process • defense response • immune response • regulation of inflammatory response to antigenic stimulus • response to external stimulus • regulation of inflammatory response • positive regulation of inflammatory response to antigenic stimulus • acute inflammatory response to antigenic stimulus • regulation of response to stimulus • immune system process • positive regulation of defense response • regulation of acute inflammatory response • regulation of immune response • inflammatory response • neuron recognition • neuron projection fasciculation • axonal fasciculation • cell recognition • axon development • inorganic ion homeostasis • intracellular calcium ion homeostasis • homeostatic process • calcium ion homeostasis • regulation of cytosolic calcium ion concentration • regulation of presynaptic cytosolic calcium ion concentration • cellular homeostasis • neuron cellular homeostasis • chemical homeostasis • intracellular monoatomic cation homeostasis • monoatomic ion homeostasis • intracellular chemical homeostasis • monoatomic cation homeostasis • intracellular monoatomic ion homeostasis • regulation of behavior • feeding behavior • regulation of feeding behavior • glucose homeostasis • carbohydrate homeostasis • G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger • cannabinoid signaling pathway • negative regulation of monoatomic ion transport • monoatomic ion transport • serotonin secretion • negative regulation of serotonin secretion • regulation of monoatomic ion transport • serotonin transport • regulation of serotonin secretion • trans-synaptic signaling • synaptic transmission, GABAergic • modulation of chemical synaptic transmission • chemical synaptic transmission • regulation of trans-synaptic signaling • anterograde trans-synaptic signaling • regulation of synaptic transmission, GABAergic • multi-multicellular organism process • maternal process involved in female pregnancy • female pregnancy • multi-organism reproductive process • circulatory system process • regulation of blood pressure • positive regulation of blood pressure • blood circulation • response to ethanol • regulation of action potential • negative regulation of action potential • action potential • regulation of membrane potential • trans-synaptic signaling by endocannabinoid • retrograde trans-synaptic signaling • retrograde trans-synaptic signaling by endocannabinoid • trans-synaptic signaling by lipid • retrograde trans-synaptic signaling by lipid • regulation of leukocyte activation • cell activation • regulation of cell activation • myeloid leukocyte activation • leukocyte activation • negative regulation of cell activation • negative regulation of mast cell activation • negative regulation of immune system process • mast cell activation • regulation of mast cell activation • negative regulation of multicellular organismal process • negative regulation of leukocyte activation • synaptic transmission, glutamatergic • regulation of synaptic transmission, glutamatergic • response to nutrient levels • response to nutrient • response to nicotine • biological process involved in interspecies interaction between organisms • response to other organism • response to lipopolysaccharide • response to biotic stimulus • response to bacterium • response to external biotic stimulus • response to molecule of bacterial origin • response to cocaine • response to alkaloid • acute-phase response • regulation of heat generation • positive regulation of heat generation • heat generation • positive regulation of fever generation • fever generation • multicellular organismal-level homeostasis • temperature homeostasis • positive regulation of multicellular organismal process • regulation of fever generation • negative regulation of blood pressure • catabolic process • negative regulation of fatty acid oxidation • negative regulation of small molecule metabolic process • negative regulation of fatty acid beta-oxidation • oxoacid metabolic process • ketone metabolic process • regulation of lipid metabolic process • organic acid metabolic process • organic acid catabolic process • regulation of primary metabolic process • regulation of fatty acid oxidation • monocarboxylic acid catabolic process • fatty acid oxidation • regulation of small molecule metabolic process • carboxylic acid catabolic process • fatty acid beta-oxidation • small molecule metabolic process • lipid oxidation • negative regulation of lipid catabolic process • negative regulation of catabolic process • fatty acid metabolic process • lipid catabolic process • negative regulation of fatty acid metabolic process • negative regulation of metabolic process • regulation of fatty acid beta-oxidation • carboxylic acid metabolic process • primary metabolic process • lipid modification • regulation of catabolic process • regulation of lipid catabolic process • regulation of ketone metabolic process • fatty acid catabolic process • regulation of fatty acid metabolic process • monocarboxylic acid metabolic process • small molecule catabolic process • negative regulation of lipid metabolic process • lipid metabolic process • actin cytoskeleton • presynapse • presynaptic membrane • plasma membrane region • synaptic membrane • glutamatergic synapse • mitochondrial membrane • mitochondrion • organelle outer membrane • organelle envelope • mitochondrial envelope • mitochondrial outer membrane • outer membrane • membrane microdomain • membrane raft • growth cone • axon • distal axon • site of polarized growth • GABA-ergic synapse
SCOP2	Domain Identifier	• Transducin (heterotrimeric G protein), gamma chain • G protein-coupled receptor-like
SCOP2	Family Identifier	• Transducin (heterotrimeric G protein), gamma chain • G protein-coupled receptor-like
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	9GF
PDB Residues	L:L:?1
Environment Details	Open EMBL-EBI Page
Code	9GF
Name	2-[(1R,2R,5R)-5-hydroxy-2-(3-hydroxypropyl)cyclohexyl]-5-(2-methyloctan-2-yl)phenol
Synonyms
Identifier
Formula	C24 H40 O3
Molecular Weight	376.573
SMILES
PubChem	104895
Formal Charge	0
Total Atoms	67
Total Chiral Atoms	3
Total Bonds	68
Total Aromatic Bonds	6


Code	7IC
PDB Residues	W:W:?1
Environment Details	Open EMBL-EBI Page
Code	7IC
Name	6-methyl-3-[(1S)-2-nitro-1-thiophen-2-yl-ethyl]-2-phenyl-1H-indole
Synonyms
Identifier
Formula	C21 H18 N2 O2 S
Molecular Weight	362.445
SMILES
PubChem	129407013
Formal Charge	0
Total Atoms	44
Total Chiral Atoms	1
Total Bonds	47
Total Aromatic Bonds	21


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P21554
Sequence	>7WV9_nogp_Chain_R E C F M V L N P S Q Q L A I A V L S L T L G T F T V L E N L L V L C V I L H S R S L R C R P S Y H F I G S L A V A D L L G S V I F V Y S F I D F H V F H R K D S R N V F L F K L G G V T A S F T A S V G S L F L T A I D R Y I S I H R P L A Y K R I V T R P K A V V A F C L M W T I A I V I A V L P L L G W N C E K L Q S V C S D I F P H I D E T Y L M F W I G V T S V L L L F I V Y A Y M Y I L W K A H S H A V R M I Q R G T Q K P D Q A R M D I R L A K T L V L I L V V L I I C W G P L L A I M V Y D V F G K M N K L I K T V F A F C S M L C L L N S T V N P I I Y A L R S K D L R H A F R S M Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	9B65	A	Lipid	Cannabinoid	CB₁	Homo sapiens	KCA	-	Gi1/β1/γ2	3.03	2025-03-05	10.1038/s41586-025-08618-7
	9B65 (No Gprot)	A	Lipid	Cannabinoid	CB₁	Homo sapiens	KCA	-		3.03	2025-03-05	10.1038/s41586-025-08618-7
	9B54	A	Lipid	Cannabinoid	CB₁	Homo sapiens	A1AIW	-	Gi1/β1/γ2	2.86	2025-03-05	10.1038/s41586-025-08618-7
	9B54 (No Gprot)	A	Lipid	Cannabinoid	CB₁	Homo sapiens	A1AIW	-		2.86	2025-03-05	10.1038/s41586-025-08618-7
	9BA0	A	Lipid	Cannabinoid	CB₁	Homo sapiens	A1AKN	-	-	3.13	2024-11-20	10.1038/s41467-024-54206-0
	9B9Z	A	Lipid	Cannabinoid	CB₁	Homo sapiens	A1AKO	-	-	3.3	2024-11-20	10.1038/s41467-024-54206-0
	9B9Y	A	Lipid	Cannabinoid	CB₁	Homo sapiens	7DY	-	-	3.5	2024-11-20	10.1038/s41467-024-54206-0
	9ERX	A	Lipid	Cannabinoid	CB₁	Homo sapiens	D9-THC analog	-	Gi1/β1/γ2	2.9	2024-06-26	10.21203/rs.3.rs-4277209/v1
	9ERX (No Gprot)	A	Lipid	Cannabinoid	CB₁	Homo sapiens	D9-THC analog	-		2.9	2024-06-26	10.21203/rs.3.rs-4277209/v1
	8IKH	A	Lipid	Cannabinoid	CB₁	Homo sapiens	-	Q2L	Gi1/β1/γ1	3.3	2024-06-05	10.1073/pnas.2321532121
	8IKH (No Gprot)	A	Lipid	Cannabinoid	CB₁	Homo sapiens	-	Q2L		3.3	2024-06-05	10.1073/pnas.2321532121
	8IKG	A	Lipid	Cannabinoid	CB₁	Homo sapiens	-	Q2B	Gi1/β1/γ1	3.4	2024-06-05	10.1073/pnas.2321532121
	8IKG (No Gprot)	A	Lipid	Cannabinoid	CB₁	Homo sapiens	-	Q2B		3.4	2024-06-05	10.1073/pnas.2321532121
	8WU1	A	Lipid	Cannabinoid	CB₁	Homo sapiens	PubChem 119025665	-	Arrestin2	3.2	2024-03-20	To be published
	8WRZ	A	Lipid	Cannabinoid	CB₁	Homo sapiens	PubChem 102336704	-	Arrestin2	3.6	2024-02-28	10.1093/procel/pwad055
	8GAG	A	Lipid	Cannabinoid	CB₁	Homo sapiens	PubChem 170838490	-	Gi1/β1/γ2	3.3	2024-02-28	To be published
	8GAG (No Gprot)	A	Lipid	Cannabinoid	CB₁	Homo sapiens	PubChem 170838490	-		3.3	2024-02-28	To be published
	8K8J	A	Lipid	Cannabinoid	CB₁	Homo sapiens	Fenofibrate	-	chim(Gs-CtGq)/β1/γ2	2.88	2024-02-14	10.1002/advs.202306311
	8K8J (No Gprot)	A	Lipid	Cannabinoid	CB₁	Homo sapiens	Fenofibrate	-		2.88	2024-02-14	10.1002/advs.202306311
	8GHV	A	Lipid	Cannabinoid	CB₁	Homo sapiens	AMG315	-	Gi1/β1/γ2	2.8	2023-05-24	10.1038/s41467-023-37864-4
	8GHV (No Gprot)	A	Lipid	Cannabinoid	CB₁	Homo sapiens	AMG315	-		2.8	2023-05-24	10.1038/s41467-023-37864-4
	7FEE	A	Lipid	Cannabinoid	CB₁	Homo sapiens	CP55940	ZCZ011	-	2.7	2022-06-15	10.1038/s41589-022-01038-y
	7WV9	A	Lipid	Cannabinoid	CB₁	Homo sapiens	CP55940	ZCZ011	Gi2/β1/γ2	3.36	2022-06-15	10.1038/s41589-022-01038-y
	7WV9 (No Gprot)	A	Lipid	Cannabinoid	CB₁	Homo sapiens	CP55940	ZCZ011		3.36	2022-06-15	10.1038/s41589-022-01038-y
	7V3Z	A	Lipid	Cannabinoid	CB₁	Homo sapiens	CP55940	-	-	3.29	2021-11-24	10.1021/jacs.1c06847
	6KPG	A	Lipid	Cannabinoid	CB₁	Homo sapiens	AM841	-	Gi1/β1/γ2	3	2020-02-12	10.1016/j.cell.2020.01.008
	6KPG (No Gprot)	A	Lipid	Cannabinoid	CB₁	Homo sapiens	AM841	-		3	2020-02-12	10.1016/j.cell.2020.01.008
	6KQI	A	Lipid	Cannabinoid	CB₁	Homo sapiens	CP55940	Org27569	-	3.25	2019-10-23	10.1038/s41589-019-0387-2
	6N4B	A	Lipid	Cannabinoid	CB₁	Homo sapiens	MDMB-Fubinaca	-	Gi1/β1/γ2	3	2019-01-30	10.1016/j.cell.2018.11.040
	6N4B (No Gprot)	A	Lipid	Cannabinoid	CB₁	Homo sapiens	MDMB-Fubinaca	-		3	2019-01-30	10.1016/j.cell.2018.11.040
	5XRA	A	Lipid	Cannabinoid	CB₁	Homo sapiens	AM11542	-	-	2.8	2017-07-12	10.1038/nature23272
	5XR8	A	Lipid	Cannabinoid	CB₁	Homo sapiens	AM841	-	-	2.95	2017-07-12	10.1038/nature23272
	5U09	A	Lipid	Cannabinoid	CB₁	Homo sapiens	Taranabant	-	-	2.6	2016-12-07	10.1038/nature20613
	5TGZ	A	Lipid	Cannabinoid	CB₁	Homo sapiens	AM6538	-	-	2.8	2016-11-02	10.1016/j.cell.2016.10.004

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