Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg Int. Strength Num Of Links Community ConSurf
1L:L:?1 7.10751210
2R:R:L126 3.895496
3R:R:T130 5.464507
4R:R:E133 8.135438
5R:R:N134 8.3439
6R:R:V137 2.905409
7R:R:I141 2.6407
8R:R:R145 7.835446
9R:R:L147 6.054549
10R:R:R150 4.3025445
11R:R:P151 3.34405
12R:R:Y153 8.44167649
13R:R:L159 3.895439
14R:R:D163 6.785439
15R:R:L165 3.975456
16R:R:F174 5.7625405
17R:R:R186 5.666573
18R:R:Y215 5.705468
19R:R:Y224 5.7454107
20R:R:V228 3.315106
21R:R:W241 5.36409
22R:R:Q261 4.185481
23R:R:F268 5.41571715
24R:R:H270 6.98473
25R:R:I271 4.485413
26R:R:L276 2.98415
27R:R:W279 4.754516
28R:R:I280 2.86505
29R:R:Y294 4.39833629
30R:R:Y296 8.7625464
31R:R:I297 4.605429
32R:R:L298 2.49426
33R:R:W356 4.874518
34R:R:L359 3.335417
35R:R:D366 6.4525414
36R:R:Y397 3.85833629
37W:W:?1 6.21444950
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
1L:L:?1 R:R:F174 52.71494.32YesYes005
2R:R:F174 R:R:H178 23.531113.58YesNo054
3R:R:H178 R:R:L111 38.40765.14NoNo044
4L:L:?1 R:R:F177 20.187810.36YesNo004
5R:R:F177 R:R:H178 18.59915.66NoNo044
6L:L:?1 R:R:F268 63.71710.36YesYes105
7R:R:F268 R:R:I267 16.8546.28YesNo154
8R:R:I267 R:R:K376 15.17054.36NoNo042
9R:R:L111 R:R:Q116 28.372915.97NoNo044
10R:R:P113 R:R:Q116 10.44724.74NoNo024
11R:R:Q116 R:R:V179 15.61635.73NoNo044
12R:R:F174 R:R:S123 35.96052.64YesNo057
13R:R:L122 R:R:S123 33.52784.5NoNo057
14R:R:L122 R:R:T125 31.98181.47NoNo054
15R:R:L126 R:R:T125 31.96281.47YesNo064
16R:R:L126 R:R:T391 29.83354.42YesNo967
17R:R:T130 R:R:T391 30.53546.28YesNo077
18R:R:E133 R:R:T130 32.16672.82YesYes087
19R:R:E133 R:R:P394 22.852912.58YesNo389
20L:L:?1 R:R:F200 39.54576.04YesNo107
21R:R:C386 R:R:F200 40.35665.59NoNo177
22R:R:C386 R:R:W356 40.24283.92NoYes178
23R:R:N389 R:R:W356 1006.78NoYes098
24R:R:N389 R:R:N393 96.92710.9NoNo099
25R:R:N393 R:R:Y397 95.91692.33NoYes099
26R:R:L207 R:R:Y397 41.02533.52NoYes089
27R:R:L159 R:R:L207 48.89744.15YesNo098
28R:R:D163 R:R:L159 34.59485.43YesYes399
29L:L:?1 R:R:F379 42.580719.86YesNo004
30R:R:F379 R:R:L359 42.33892.44NoYes047
31R:R:L359 R:R:W356 42.1354.56YesYes178
32R:R:P394 R:R:V137 45.38821.77NoYes099
33R:R:I141 R:R:V137 37.6823.07YesYes079
34R:R:I141 R:R:I156 33.54672.94YesNo078
35R:R:I156 R:R:Y153 32.41332.42NoYes089
36R:R:R150 R:R:Y153 17.83569.26YesYes459
37R:R:P151 R:R:R150 17.10062.88YesYes055
38R:R:P151 R:R:V228 11.97895.3YesYes056
39R:R:L159 R:R:S206 15.19893YesNo098
40R:R:S158 R:R:S206 13.05544.89NoNo098
41R:R:F237 R:R:S158 10.90257.93NoNo089
42L:L:?1 R:R:S173 19.9275.32YesNo004
43R:R:K192 R:R:S173 18.5473.06NoNo064
44R:R:K192 W:W:?1 17.04843.48NoYes060
45R:R:F180 R:R:V179 10.44723.93NoNo044
46R:R:F268 R:R:I271 53.48792.51YesYes153
47R:R:I271 R:R:Y275 52.94264.84YesNo037
48R:R:L252 R:R:Y275 42.64242.34NoNo057
49R:R:L190 R:R:L252 40.89255.54NoNo055
50R:R:L190 R:R:R186 39.13314.86NoYes053
51R:R:H270 R:R:R186 22.64435.64YesYes733
52R:R:L287 R:R:W356 10.45193.42NoYes068
53R:R:I290 R:R:L207 15.43132.85NoNo088
54R:R:Y294 R:R:Y397 69.31284.96YesYes299
55R:R:I290 R:R:Y294 15.15632.42NoYes089
56R:R:I297 R:R:Y294 71.30462.42YesYes299
57R:R:I218 R:R:I297 25.660410.3NoYes099
58R:R:I218 R:R:K300 23.36982.91NoNo095
59R:R:K300 R:R:Y296 16.38927.17NoYes654
60R:R:C257 R:R:H270 21.01777.37NoYes093
61R:R:C257 R:R:S262 17.28086.89NoNo093
62R:R:D272 R:R:S262 15.39818.83NoNo053
63R:R:D272 R:R:W255 13.50611.17NoNo055
64R:R:I280 R:R:L360 24.60764.28YesNo057
65R:R:I297 R:R:L298 36.48222.85YesYes296
66R:R:L298 R:R:L341 32.28531.38YesNo068
67R:R:A301 R:R:L341 30.18451.58NoNo088
68R:R:A301 R:R:D338 18.76511.54NoNo087
69R:R:D338 R:R:H302 11.798710.08NoNo075
70R:R:D163 R:R:N134 32.71684.04YesYes399
71R:R:L360 R:R:W356 24.5275.69NoYes078
72R:R:I280 R:R:M363 19.05914.37YesNo056
73R:R:N134 R:R:P394 23.55016.52YesNo399
74R:R:F268 R:R:M363 19.17776.22YesNo056
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


2D representation of the interactions of this orthosteric/allosteric ligand.


Links and nodes colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
L:L:?1 R:R:F170 12.09 1 Yes No 0 7 0 1
L:L:?1 R:R:S173 5.32 1 Yes No 0 4 0 1
L:L:?1 R:R:F174 4.32 1 Yes Yes 0 5 0 1
L:L:?1 R:R:F177 10.36 1 Yes No 0 4 0 1
L:L:?1 R:R:L193 3.92 1 Yes No 0 4 0 1
L:L:?1 R:R:V196 3.17 1 Yes No 0 7 0 1
L:L:?1 R:R:T197 3.13 1 Yes No 0 6 0 1
L:L:?1 R:R:F200 6.04 1 Yes No 0 7 0 1
L:L:?1 R:R:F268 10.36 1 Yes Yes 0 5 0 1
L:L:?1 R:R:P269 3.49 1 Yes No 0 3 0 1
L:L:?1 R:R:W279 3.23 1 Yes Yes 0 6 0 1
L:L:?1 R:R:F379 19.86 1 Yes No 0 4 0 1
R:R:F108 R:R:P269 4.33 0 No No 5 3 2 1
R:R:F174 R:R:I119 2.51 0 Yes No 5 5 1 2
R:R:F174 R:R:S123 2.64 0 Yes No 5 7 1 2
R:R:F170 R:R:V196 10.49 1 No No 7 7 1 1
R:R:F170 R:R:S383 2.64 1 No No 7 6 1 2
R:R:K192 R:R:S173 3.06 0 No No 6 4 2 1
R:R:F174 R:R:H178 13.58 0 Yes No 5 4 1 2
R:R:F177 R:R:H178 5.66 0 No No 4 4 1 2
R:R:F177 R:R:F189 5.36 0 No No 4 9 1 2
R:R:F189 R:R:L193 2.44 0 No No 9 4 2 1
R:R:F189 R:R:P269 10.11 0 No No 9 3 2 1
R:R:F200 R:R:V196 5.24 1 No No 7 7 1 1
R:R:T197 R:R:W279 3.64 1 No Yes 6 6 1 1
R:R:C386 R:R:F200 5.59 1 No No 7 7 2 1
R:R:T201 R:R:W279 4.85 0 No Yes 6 6 2 1
R:R:F268 R:R:S265 5.28 1 Yes No 5 4 1 2
R:R:I271 R:R:S265 7.74 1 Yes No 3 4 2 2
R:R:F268 R:R:I267 6.28 1 Yes No 5 4 1 2
R:R:D366 R:R:I267 15.39 1 Yes No 4 4 2 2
R:R:F268 R:R:I271 2.51 1 Yes Yes 5 3 1 2
R:R:F268 R:R:L276 4.87 1 Yes Yes 5 5 1 2
R:R:F268 R:R:M363 6.22 1 Yes No 5 6 1 2
R:R:D366 R:R:F268 2.39 1 Yes Yes 4 5 2 1
R:R:I271 R:R:L276 2.85 1 Yes Yes 3 5 2 2
R:R:D366 R:R:L276 2.71 1 Yes Yes 4 5 2 2
R:R:I280 R:R:W279 2.35 0 Yes Yes 5 6 2 1
R:R:T283 R:R:W279 9.7 0 No Yes 8 6 2 1
R:R:I280 R:R:M363 4.37 0 Yes No 5 6 2 2
R:R:F379 R:R:L359 2.44 0 No Yes 4 7 1 2
R:R:C386 R:R:L359 3.17 1 No Yes 7 7 2 2

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

2D representation of the interactions of this orthosteric/allosteric ligand.


Links and nodes colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:G166 R:R:L165 5.13 5 No Yes 8 6 2 1
R:R:I169 R:R:L165 2.85 5 No Yes 5 6 1 1
R:R:L165 R:R:S199 4.5 5 Yes No 6 7 1 2
R:R:L165 W:W:?1 3.42 5 Yes Yes 6 0 1 0
R:R:G166 R:R:S199 3.71 5 No No 8 7 2 2
R:R:I169 W:W:?1 11.76 5 No Yes 5 0 1 0
R:R:K192 R:R:S173 3.06 0 No No 6 4 1 2
R:R:F191 W:W:?1 9.03 0 No Yes 5 0 1 0
R:R:K192 W:W:?1 3.48 0 No Yes 6 0 1 0
R:R:G194 W:W:?1 8.45 0 No Yes 6 0 1 0
R:R:G195 W:W:?1 8.45 0 No Yes 4 0 1 0
R:R:A198 W:W:?1 2.6 0 No Yes 5 0 1 0
R:R:A248 W:W:?1 2.6 0 No Yes 7 0 1 0
R:R:V249 W:W:?1 6.14 0 No Yes 5 0 1 0

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB 7WV9_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.
Net Summary
Imin 2.33
Number of Linked Nodes 271
Number of Links 299
Number of Hubs 37
Number of Links mediated by Hubs 149
Number of Communities 10
Number of Nodes involved in Communities 58
Number of Links involved in Communities 74
Path Summary
Number Of Nodes in MetaPath 75
Number Of Links MetaPath 74
Number of Shortest Paths 48331
Length Of Smallest Path 3
Average Path Length 14.1593
Length of Longest Path 34
Minimum Path Strength 1.155
Average Path Strength 5.28944
Maximum Path Strength 15.18
Minimum Path Correlation 0.7
Average Path Correlation 0.933982
Maximum Path Correlation 0.99
Minimum % Of Corr. Nodes 4.54545
Average % Of Corr. Nodes 52.5968
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 41.8353
Maximum Path Hubs % 100
AnnotationTypeLinks
Gene OntologyMolecular Function
Gene OntologyBiological Process
Gene OntologyCellular Component
SCOP2Domain Identifier• G protein-coupled receptor-like   • Transducin (heterotrimeric G protein), gamma chain
SCOP2Family Identifier• G protein-coupled receptor-like   • Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations-• Orientations of Proteins in Membranes database (OPM)   • Protein Data Bank of Transmembrane Proteins (PDBTM)   • MemProtMD


Details about the values in these tables can be found in the corresponding documentation page .
Code9GF
PDB ResiduesL:L:?1
Environment DetailsOpen EMBL-EBI Page
Code9GF
Name2-[(1R,2R,5R)-5-hydroxy-2-(3-hydroxypropyl)cyclohexyl]-5-(2-methyloctan-2-yl)phenol
Synonyms
Identifier
FormulaC24 H40 O3
Molecular Weight376.573
SMILES
PubChem104895
Formal Charge0
Total Atoms67
Total Chiral Atoms3
Total Bonds68
Total Aromatic Bonds6

Code7IC
PDB ResiduesW:W:?1
Environment DetailsOpen EMBL-EBI Page
Code7IC
Name6-methyl-3-[(1S)-2-nitro-1-thiophen-2-yl-ethyl]-2-phenyl-1H-indole
Synonyms
Identifier
FormulaC21 H18 N2 O2 S
Molecular Weight362.445
SMILES
PubChem129407013
Formal Charge0
Total Atoms44
Total Chiral Atoms1
Total Bonds47
Total Aromatic Bonds21

PDBsumOpen PDBsum Page
ChainR
ProteinReceptor
UniProtP21554
Sequence
>7WV9_nogp_Chain_R
ECFMVLNPS QQLAIAVLS LTLGTFTVL ENLLVLCVI LHSRSLRCR 
PSYHFIGSL AVADLLGSV IFVYSFIDF HVFHRKDSR NVFLFKLGG 
VTASFTASV GSLFLTAID RYISIHRPL AYKRIVTRP KAVVAFCLM 
WTIAIVIAV LPLLGWNCE KLQSVCSDI FPHIDETYL MFWIGVTSV 
LLLFIVYAY MYILWKAHS HAVRMIQRG TQKPDQARM DIRLAKTLV 
LILVVLIIC WGPLLAIMV YDVFGKMNK LIKTVFAFC SMLCLLNST 
VNPIIYALR SKDLRHAFR SM


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  




This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
7FEEALipidCannabinoidCB1Homo sapiensCP55940ZCZ011-2.72022-06-15doi.org/10.1038/s41589-022-01038-y
7WV9ALipidCannabinoidCB1Homo sapiensCP55940ZCZ011Gi2/β1/γ23.362022-06-15doi.org/10.1038/s41589-022-01038-y
7WV9 (No Gprot) ALipidCannabinoidCB1Homo sapiensCP55940ZCZ0113.362022-06-15doi.org/10.1038/s41589-022-01038-y
8IKHALipidCannabinoidCB1Homo sapiens-Q2LGi1/β1/γ13.32024-06-05doi.org/10.1073/pnas.2321532121
8IKH (No Gprot) ALipidCannabinoidCB1Homo sapiens-Q2L3.32024-06-05doi.org/10.1073/pnas.2321532121
8IKGALipidCannabinoidCB1Homo sapiens-Q2BGi1/β1/γ13.42024-06-05doi.org/10.1073/pnas.2321532121
8IKG (No Gprot) ALipidCannabinoidCB1Homo sapiens-Q2B3.42024-06-05doi.org/10.1073/pnas.2321532121
6KQIALipidCannabinoidCB1Homo sapiensCP55940Org27569-3.252019-10-23doi.org/10.1038/s41589-019-0387-2
8K8JALipidCannabinoidCB1Homo sapiensFenofibrate-chim(Gs-CtGq)/β1/γ22.882024-02-14doi.org/10.1002/advs.202306311
8K8J (No Gprot) ALipidCannabinoidCB1Homo sapiensFenofibrate-2.882024-02-14doi.org/10.1002/advs.202306311
5TGZALipidCannabinoidCB1Homo sapiensAM6538--2.82016-11-02doi.org/10.1016/j.cell.2016.10.004
6N4BALipidCannabinoidCB1Homo sapiensMDMB-Fubinaca-Gi1/β1/γ232019-01-30doi.org/10.1016/j.cell.2018.11.040
6N4B (No Gprot) ALipidCannabinoidCB1Homo sapiensMDMB-Fubinaca-32019-01-30doi.org/10.1016/j.cell.2018.11.040
6KPGALipidCannabinoidCB1Homo sapiensAM841-Gi1/β1/γ232020-02-12doi.org/10.1016/j.cell.2020.01.008
6KPG (No Gprot) ALipidCannabinoidCB1Homo sapiensAM841-32020-02-12doi.org/10.1016/j.cell.2020.01.008
7V3ZALipidCannabinoidCB1Homo sapiensCP55940--3.292021-11-24doi.org/10.1021/jacs.1c06847
5U09ALipidCannabinoidCB1Homo sapiensTaranabant--2.62016-12-07doi.org/10.1038/nature20613
5XR8ALipidCannabinoidCB1Homo sapiensAM841--2.952017-07-12doi.org/10.1038/nature23272
5XRAALipidCannabinoidCB1Homo sapiensAM11542--2.82017-07-12doi.org/10.1038/nature23272
8GHVALipidCannabinoidCB1Homo sapiensAMG315-Gi1/β1/γ22.82023-05-24doi.org/10.1038/s41467-023-37864-4
8GHV (No Gprot) ALipidCannabinoidCB1Homo sapiensAMG315-2.82023-05-24doi.org/10.1038/s41467-023-37864-4
9B9ZALipidCannabinoidCB1Homo sapiensA1AKO--3.32024-11-20doi.org/10.1038/s41467-024-54206-0
9BA0ALipidCannabinoidCB1Homo sapiensA1AKN--3.132024-11-20doi.org/10.1038/s41467-024-54206-0
9B9YALipidCannabinoidCB1Homo sapiens7DY--3.52024-11-20doi.org/10.1038/s41467-024-54206-0
9B54ALipidCannabinoidCB1Homo sapiensA1AIW-Gi1/β1/γ22.862025-03-05doi.org/10.1038/s41586-025-08618-7
9B54 (No Gprot) ALipidCannabinoidCB1Homo sapiensA1AIW-2.862025-03-05doi.org/10.1038/s41586-025-08618-7
9B65ALipidCannabinoidCB1Homo sapiensKCA-Gi1/β1/γ23.032025-03-05doi.org/10.1038/s41586-025-08618-7
9B65 (No Gprot) ALipidCannabinoidCB1Homo sapiensKCA-3.032025-03-05doi.org/10.1038/s41586-025-08618-7
8WRZALipidCannabinoidCB1Homo sapiensPubChem 102336704-Arrestin23.62024-02-28doi.org/10.1093/procel/pwad055
9ERXALipidCannabinoidCB1Homo sapiensD9-THC analog-Gi1/β1/γ22.92024-06-26doi.org/10.21203/rs.3.rs-4277209/v1
9ERX (No Gprot) ALipidCannabinoidCB1Homo sapiensD9-THC analog-2.92024-06-26doi.org/10.21203/rs.3.rs-4277209/v1
8WU1ALipidCannabinoidCB1Homo sapiensPubChem 119025665-Arrestin23.22024-03-20doi.org/10.1016/j.cell.2023.11.017
9DGIALipidCannabinoidCB1Homo sapiensZ8526711350--3.352025-04-30doi.org/10.1038/s41467-025-57136-7
9EGOALipidCannabinoidCB1Homo sapiensYVF-Gi1/β1/γ23.22025-04-30doi.org/10.1038/s41467-025-57136-7
9EGO (No Gprot) ALipidCannabinoidCB1Homo sapiensYVF-3.22025-04-30doi.org/10.1038/s41467-025-57136-7
8GAGALipidCannabinoidCB1Homo sapiensPubChem 170838490-Gi1/β1/γ23.32024-02-28To be published
8GAG (No Gprot) ALipidCannabinoidCB1Homo sapiensPubChem 170838490-3.32024-02-28To be published




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Download 7WV9_nogp.zip



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