psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:C107	R:R:E106	4.56	No	No	0	2	4
2	R:R:K373	R:R:M109	2.88	No	No	0	3	3
3	R:R:Q116	R:R:V110	7.16	Yes	No	0	4	3
4	R:R:H181	R:R:V110	2.77	No	No	0	3	3
5	R:R:L111	R:R:N112	4.12	Yes	Yes	4	4	6
6	R:R:L111	R:R:Q115	3.99	Yes	Yes	4	4	2
7	R:R:L111	R:R:Q116	2.66	Yes	Yes	4	4	4
8	R:R:L111	R:R:T377	4.42	Yes	No	0	4	1
9	R:R:N112	R:R:Q115	9.24	Yes	Yes	4	6	2
10	R:R:N112	R:R:Q116	5.28	Yes	Yes	4	6	4
11	R:R:Q115	R:R:Q116	11.52	Yes	Yes	4	2	4
12	R:R:F381	R:R:Q115	2.34	No	Yes	0	4	2
13	R:R:I119	R:R:Q116	2.74	No	Yes	0	5	4
14	R:R:F381	R:R:I119	3.77	No	No	0	4	5
15	R:R:I119	R:R:M384	5.83	No	No	0	5	5
16	R:R:S123	R:R:V171	4.85	No	No	0	7	7
17	R:R:I175	R:R:L124	2.85	No	No	0	5	3
18	R:R:F129	R:R:T125	2.59	No	No	0	4	4
19	R:R:L126	R:R:T391	2.95	No	Yes	0	6	7
20	R:R:G127	R:R:T130	3.64	No	Yes	0	6	7
21	R:R:F129	R:R:L132	2.44	No	No	0	4	3
22	R:R:S167	R:R:T130	4.8	No	Yes	0	7	7
23	R:R:T130	R:R:T391	4.71	Yes	Yes	0	7	7
24	R:R:E133	R:R:L132	6.63	No	No	0	8	3
25	R:R:E133	R:R:L136	2.65	No	No	0	8	7
26	R:R:E133	R:R:I395	10.93	No	No	0	8	6
27	R:R:N134	R:R:V137	2.96	Yes	No	0	9	9
28	R:R:A160	R:R:N134	4.69	No	Yes	0	9	9
29	R:R:L164	R:R:N134	8.24	No	Yes	0	7	9
30	R:R:N134	R:R:P394	3.26	Yes	No	0	9	9
31	R:R:A398	R:R:V137	3.39	No	No	0	7	9
32	R:R:L138	R:R:L142	5.54	No	No	0	7	4
33	R:R:I141	R:R:V140	3.07	No	No	5	7	8
34	R:R:L404	R:R:V140	5.96	Yes	No	5	8	8
35	R:R:F408	R:R:V140	15.73	No	No	0	7	8
36	R:R:I141	R:R:L404	8.56	No	Yes	5	7	8
37	R:R:L142	R:R:S144	3	No	No	0	4	6
38	R:R:F408	R:R:H143	4.53	No	No	0	7	5
39	R:R:R148	R:R:S144	7.91	No	No	0	8	6
40	R:R:L147	R:R:Y153	7.03	No	No	0	9	9
41	R:R:R150	R:R:Y153	15.43	No	No	1	5	9
42	R:R:D403	R:R:R150	3.57	No	No	1	6	5
43	R:R:H154	R:R:P151	3.05	Yes	Yes	1	3	5
44	R:R:F155	R:R:P151	2.89	Yes	Yes	1	8	5
45	R:R:P151	R:R:V228	3.53	Yes	Yes	1	5	6
46	R:R:D213	R:R:S152	4.42	No	No	0	9	8
47	R:R:D403	R:R:Y153	8.05	No	No	1	6	9
48	R:R:F155	R:R:H154	2.26	Yes	Yes	1	8	3
49	R:R:H154	R:R:R230	2.26	Yes	No	0	3	1
50	R:R:A233	R:R:H154	2.93	No	Yes	1	7	3
51	R:R:F155	R:R:L209	7.31	Yes	No	0	8	6
52	R:R:A233	R:R:F155	2.77	No	Yes	1	7	8
53	R:R:I156	R:R:T210	3.04	No	No	0	8	9
54	R:R:I156	R:R:Y397	4.84	No	Yes	0	8	9
55	R:R:F237	R:R:S158	7.93	No	No	0	8	9
56	R:R:D163	R:R:L159	5.43	Yes	Yes	6	9	9
57	R:R:L159	R:R:S203	3	Yes	No	6	9	9
58	R:R:L159	R:R:S206	6.01	Yes	No	0	9	8
59	R:R:L159	R:R:L207	5.54	Yes	No	0	9	8
60	R:R:A162	R:R:W241	2.59	No	Yes	0	8	9
61	R:R:D163	R:R:S203	7.36	Yes	No	6	9	9
62	R:R:D163	R:R:S390	8.83	Yes	No	0	9	9
63	R:R:D163	R:R:P394	6.44	Yes	No	0	9	9
64	R:R:L165	W:W:?1	8.19	No	Yes	0	6	0
65	R:R:G166	R:R:I169	3.53	No	No	0	8	5
66	R:R:G166	R:R:S199	3.71	No	No	0	8	7
67	R:R:I169	R:R:V196	3.07	No	No	0	5	7
68	R:R:I169	W:W:?1	3.62	No	Yes	0	5	0
69	R:R:F170	R:R:F174	8.57	No	No	0	7	5
70	R:R:F170	R:R:L387	7.31	No	No	0	7	7
71	R:R:K192	R:R:S173	6.12	No	No	0	6	4
72	R:R:D176	R:R:F177	4.78	No	No	0	3	4
73	R:R:D176	R:R:R182	3.57	No	No	0	3	4
74	R:R:F177	R:R:F189	5.36	No	No	8	4	9
75	R:R:F177	R:R:K192	2.48	No	No	8	4	6
76	R:R:D184	R:R:R182	15.48	No	No	0	2	4
77	R:R:S185	R:R:V188	3.23	No	No	0	7	5
78	R:R:N187	R:R:R186	10.85	No	No	0	1	3
79	R:R:F189	R:R:K192	8.69	No	No	8	9	6
80	R:R:F191	W:W:?1	28.84	No	Yes	0	5	0
81	R:R:G194	R:R:G195	2.11	No	No	7	6	4
82	R:R:G194	W:W:?1	2.89	No	Yes	7	6	0
83	R:R:G195	W:W:?1	13.02	No	Yes	7	4	0
84	R:R:F200	R:R:V196	2.62	Yes	No	0	7	7
85	R:R:T197	R:R:Y275	3.75	No	Yes	0	6	7
86	R:R:T197	R:R:W279	7.28	No	No	0	6	6
87	R:R:F200	R:R:S199	2.64	Yes	No	0	7	7
88	R:R:F200	R:R:W279	2	Yes	No	0	7	6
89	R:R:C386	R:R:F200	4.19	No	Yes	0	7	7
90	R:R:T201	R:R:W279	7.28	No	No	0	6	6
91	R:R:A202	R:R:W241	7.78	No	Yes	0	7	9
92	R:R:T283	R:R:V204	4.76	No	No	2	8	7
93	R:R:L286	R:R:V204	2.98	Yes	No	0	8	7
94	R:R:V204	R:R:W356	3.68	No	Yes	2	7	8
95	R:R:G205	R:R:M240	3.49	No	No	0	5	6
96	R:R:L207	R:R:Y397	4.69	No	Yes	0	8	9
97	R:R:F208	R:R:I212	7.54	No	No	0	7	7
98	R:R:F208	R:R:L286	12.18	No	Yes	0	7	8
99	R:R:F208	R:R:F289	5.36	No	No	0	7	6
100	R:R:R214	R:R:T210	2.59	No	No	0	9	9
101	R:R:A211	R:R:I290	4.87	No	No	0	8	8
102	R:R:I212	R:R:I216	2.94	No	No	0	7	5
103	R:R:D213	R:R:Y224	8.05	No	Yes	1	9	7
104	R:R:D213	R:R:V228	4.38	No	Yes	1	9	6
105	R:R:R214	R:R:Y294	7.2	No	Yes	0	9	9
106	R:R:R214	R:R:Y397	6.17	No	Yes	0	9	9
107	R:R:H219	R:R:Y215	19.6	No	Yes	3	6	8
108	R:R:A293	R:R:Y215	4	No	Yes	0	7	8
109	R:R:Y215	R:R:Y296	13.9	Yes	Yes	3	8	4
110	R:R:I216	R:R:I227	4.42	No	No	0	5	4
111	R:R:I216	R:R:V228	3.07	No	Yes	0	5	6
112	R:R:I218	R:R:S217	4.64	No	No	0	9	8
113	R:R:S217	R:R:Y224	5.09	No	Yes	0	8	7
114	R:R:I218	R:R:I297	4.42	No	No	0	9	9
115	R:R:I218	R:R:K300	2.91	No	Yes	0	9	5
116	R:R:H219	R:R:R220	7.9	No	No	0	6	5
117	R:R:H219	R:R:Y296	13.07	No	Yes	3	6	4
118	R:R:A223	R:R:R226	5.53	No	No	0	5	4
119	R:R:K225	R:R:Y224	2.39	No	Yes	0	4	7
120	R:R:V228	R:R:Y224	2.52	Yes	Yes	1	6	7
121	R:R:P231	R:R:T229	6.99	No	No	0	4	8
122	R:R:K232	R:R:T229	3	No	No	0	5	8
123	R:R:F237	R:R:W241	6.01	No	Yes	0	8	9
124	R:R:L239	R:R:T242	2.95	No	No	0	3	4
125	R:R:I243	R:R:L239	2.85	No	No	0	5	3
126	R:R:W241	W:W:?1	2.89	Yes	Yes	0	9	0
127	R:R:I245	W:W:?1	9.66	No	Yes	0	4	0
128	R:R:F278	R:R:I247	2.51	No	No	0	6	5
129	R:R:A248	W:W:?1	4	No	Yes	0	7	0
130	R:R:L250	R:R:P251	3.28	No	No	0	5	6
131	R:R:P251	R:R:Y275	19.47	No	Yes	0	6	7
132	R:R:L252	R:R:L253	5.54	No	No	0	5	5
133	R:R:I271	R:R:Y275	9.67	No	Yes	0	3	7
134	R:R:I271	R:R:L276	2.85	No	No	0	3	5
135	R:R:D272	R:R:T274	7.23	No	No	0	5	5
136	R:R:D272	R:R:Y275	3.45	No	Yes	0	5	7
137	R:R:E273	R:R:T274	8.47	No	No	0	3	5
138	R:R:I280	R:R:M277	5.83	Yes	No	0	5	4
139	R:R:F278	R:R:V282	3.93	No	No	0	6	6
140	R:R:G281	R:R:I280	3.53	No	Yes	0	3	5
141	R:R:I280	R:R:L360	5.71	Yes	No	0	5	7
142	R:R:I280	R:R:V364	3.07	Yes	No	0	5	6
143	R:R:T283	R:R:W356	3.64	No	Yes	2	8	8
144	R:R:L287	R:R:L352	5.54	No	No	0	6	9
145	R:R:L287	R:R:W356	4.56	No	Yes	0	6	8
146	R:R:I290	R:R:Y294	2.42	No	Yes	0	8	9
147	R:R:I297	R:R:Y294	2.42	No	Yes	0	9	9
148	R:R:L345	R:R:Y294	5.86	No	Yes	0	8	9
149	R:R:L349	R:R:Y294	10.55	No	Yes	0	8	9
150	R:R:W299	R:R:Y296	2.89	No	Yes	3	3	4
151	R:R:K300	R:R:Y296	5.97	Yes	Yes	3	5	4
152	R:R:K300	R:R:W299	5.8	Yes	No	3	5	3
153	R:R:A301	R:R:D338	3.09	No	Yes	0	8	7
154	R:R:D338	R:R:H302	8.82	Yes	No	0	7	5
155	R:R:H304	R:R:M308	2.63	No	No	0	7	7
156	R:R:H304	R:R:M337	3.94	No	No	0	7	6
157	R:R:K402	R:R:R340	2.48	No	No	0	5	7
158	R:R:R400	R:R:T344	15.52	No	No	0	7	8
159	R:R:I348	R:R:I396	2.94	No	No	0	8	9
160	R:R:I348	R:R:Y397	4.84	No	Yes	0	8	9
161	R:R:C355	R:R:W356	3.92	No	Yes	2	8	8
162	R:R:C355	R:R:N389	9.45	No	No	2	8	9
163	R:R:L360	R:R:W356	4.56	No	Yes	0	7	8
164	R:R:N389	R:R:W356	9.04	No	Yes	2	9	8
165	R:R:G357	R:R:P358	4.06	No	No	0	5	9
166	R:R:L359	R:R:L360	4.15	Yes	No	0	7	7
167	R:R:L359	R:R:M363	4.24	Yes	No	0	7	6
168	R:R:F379	R:R:L359	2.44	No	Yes	0	4	7
169	R:R:C386	R:R:L359	3.17	No	Yes	0	7	7
170	R:R:D366	R:R:I362	2.8	No	No	0	4	4
171	R:R:D366	R:R:I375	4.2	No	No	0	4	3
172	R:R:F368	R:R:V367	2.62	No	No	0	5	4
173	R:R:L374	R:R:T377	4.42	No	No	0	4	1
174	R:R:L374	R:R:V378	2.98	No	No	0	4	4
175	R:R:F379	R:R:S383	3.96	No	No	0	4	6
176	R:R:L388	R:R:T391	7.37	No	Yes	0	5	7
177	R:R:N389	R:R:N393	4.09	No	No	0	9	9
178	R:R:T391	R:R:V392	3.17	Yes	No	0	7	6
179	R:R:N393	R:R:Y397	3.49	No	Yes	0	9	9
180	R:R:K402	R:R:R405	8.66	No	No	0	5	8
181	R:R:H406	R:R:K402	5.24	No	No	0	4	5
182	R:R:A160	R:R:G157	1.95	No	No	0	9	6
183	R:R:A198	R:R:G195	1.95	No	No	0	5	4
184	R:R:C382	R:R:P358	1.88	No	No	0	5	9
185	R:R:G281	R:R:S284	1.86	No	No	0	3	5
186	R:R:A202	R:R:A244	1.79	No	No	0	7	8
187	R:R:A305	R:R:A335	1.79	No	No	0	5	4
188	R:R:G205	R:R:L286	1.71	No	Yes	0	5	8
189	R:R:G254	R:R:N256	1.7	No	No	0	5	6
190	R:R:N112	R:R:P113	1.63	Yes	No	0	6	2
191	R:R:N256	R:R:P251	1.63	No	No	0	6	6
192	R:R:C107	R:R:M109	1.62	No	No	0	2	3
193	R:R:A120	R:R:I175	1.62	No	No	0	5	5
194	R:R:A223	R:R:I227	1.62	No	No	0	5	4
195	R:R:S390	R:R:T130	1.6	No	Yes	0	9	7
196	R:R:V351	R:R:V392	1.6	No	No	0	6	6
197	R:R:T125	R:R:V121	1.59	No	No	0	4	4
198	R:R:A236	R:R:L209	1.58	No	No	0	5	6
199	R:R:A342	R:R:L298	1.58	No	No	0	7	6
200	R:R:A301	R:R:L341	1.58	No	No	0	8	8
201	R:R:A398	R:R:L404	1.58	No	Yes	0	7	8
202	R:R:T125	R:R:T128	1.57	No	No	0	4	5
203	R:R:A305	R:R:D338	1.54	No	Yes	0	5	7
204	R:R:I354	R:R:V350	1.54	No	No	0	5	6
205	R:R:K300	R:R:S303	1.53	Yes	No	0	5	5
206	R:R:M384	R:R:S383	1.53	No	No	0	5	6
207	R:R:I247	R:R:T201	1.52	No	No	0	5	6
208	R:R:M277	R:R:V367	1.52	No	No	0	4	4
209	R:R:M295	R:R:V291	1.52	No	No	0	3	5
210	R:R:L147	R:R:S146	1.5	No	No	0	9	5
211	R:R:L387	R:R:S390	1.5	No	No	0	7	9
212	R:R:L404	R:R:S401	1.5	Yes	No	0	8	8
213	R:R:L164	R:R:V168	1.49	No	No	0	7	4
214	R:R:N187	R:R:S185	1.49	No	No	0	1	7
215	R:R:L253	R:R:V249	1.49	No	No	0	5	5
216	R:R:L286	R:R:V285	1.49	Yes	No	0	8	6
217	R:R:L349	R:R:V291	1.49	No	No	0	8	5
218	R:R:L352	R:R:V291	1.49	No	No	0	9	5
219	R:R:L347	R:R:V350	1.49	No	No	0	7	6
220	R:R:L347	R:R:V351	1.49	No	No	0	7	6
221	R:R:L193	R:R:T197	1.47	No	No	0	4	6
222	R:R:I353	R:R:I354	1.47	No	No	0	6	5
223	R:R:P151	R:R:R150	1.44	Yes	No	1	5	5
224	R:R:P221	R:R:R220	1.44	No	No	0	8	5
225	R:R:P231	R:R:R230	1.44	No	No	0	4	1
226	R:R:K376	R:R:M371	1.44	No	No	0	2	1
227	R:R:I375	R:R:N372	1.42	No	No	0	3	1
228	R:R:L239	R:R:M240	1.41	No	No	0	3	6
229	R:R:L341	R:R:M337	1.41	No	No	0	8	6
230	R:R:L138	R:R:N134	1.37	No	Yes	0	7	9
231	R:R:D338	R:R:L298	1.36	Yes	No	0	7	6
232	R:R:A361	R:R:Y365	1.33	No	No	0	5	4
233	R:R:R145	R:R:S146	1.32	No	No	0	6	5
234	R:R:R307	R:R:S303	1.32	No	No	0	4	5
235	R:R:V364	R:R:Y365	1.26	No	No	0	6	4
236	R:R:I339	R:R:R336	1.25	No	No	0	5	4
237	R:R:I396	R:R:R400	1.25	No	No	0	9	7
238	R:R:F189	R:R:K183	1.24	No	No	0	9	6
239	R:R:K343	R:R:R400	1.24	No	No	0	7	7
240	R:R:L190	R:R:R186	1.21	No	No	0	5	3
241	R:R:F108	R:R:H181	1.13	No	No	0	5	3
242	R:R:H304	R:R:R307	1.13	No	No	0	7	4
243	R:R:Y215	R:R:Y292	0.99	Yes	No	0	8	4

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	R:R:L111	3.7975	4	4	4
2	R:R:N112	5.0675	4	4	6
3	R:R:Q115	6.7725	4	4	2
4	R:R:Q116	5.872	5	4	4
5	R:R:T130	3.6875	4	0	7
6	R:R:N134	4.104	5	0	9
7	R:R:P151	2.7275	4	1	5
8	R:R:H154	2.625	4	1	3
9	R:R:F155	3.8075	4	1	8
10	R:R:L159	4.995	4	6	9
11	R:R:D163	7.015	4	6	9
12	R:R:F200	2.8625	4	0	7
13	R:R:Y215	9.6225	4	3	8
14	R:R:Y224	4.5125	4	1	7
15	R:R:V228	3.375	4	1	6
16	R:R:W241	4.8175	4	0	9
17	R:R:Y275	9.085	4	0	7
18	R:R:I280	4.535	4	0	5
19	R:R:L286	4.59	4	0	8
20	R:R:Y294	5.69	5	0	9
21	R:R:Y296	8.9575	4	3	4
22	R:R:K300	4.0525	4	3	5
23	R:R:D338	3.7025	4	0	7
24	R:R:W356	4.9	6	2	8
25	R:R:L359	3.5	4	0	7
26	R:R:T391	4.55	4	0	7
27	R:R:Y397	4.806	5	0	9
28	R:R:L404	4.4	4	5	8
29	W:W:?1	9.13875	8	7	0

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:I119	R:R:Q116	22.426	2.74	No	Yes	0	5	4
2	R:R:I119	R:R:M384	28.2249	5.83	No	No	0	5	5
3	R:R:T130	R:R:T391	16.5878	4.71	Yes	Yes	0	7	7
4	R:R:S390	R:R:T130	21.7653	1.6	No	Yes	0	9	7
5	R:R:D163	R:R:S390	28.2347	8.83	Yes	No	0	9	9
6	R:R:D163	R:R:L159	55.0592	5.43	Yes	Yes	6	9	9
7	R:R:L159	R:R:L207	59.0434	5.54	Yes	No	0	9	8
8	R:R:L207	R:R:Y397	60.1381	4.69	No	Yes	0	8	9
9	R:R:N393	R:R:Y397	63.3136	3.49	No	Yes	0	9	9
10	R:R:N389	R:R:N393	63.3531	4.09	No	No	0	9	9
11	R:R:N389	R:R:W356	62.8501	9.04	No	Yes	2	9	8
12	R:R:L360	R:R:W356	100	4.56	No	Yes	0	7	8
13	R:R:L359	R:R:L360	90.2367	4.15	Yes	No	0	7	7
14	R:R:F379	R:R:L359	33.7081	2.44	No	Yes	0	4	7
15	R:R:F379	R:R:S383	32.0217	3.96	No	No	0	4	6
16	R:R:M384	R:R:S383	30.1479	1.53	No	No	0	5	6
17	R:R:N134	R:R:P394	30	3.26	Yes	No	0	9	9
18	R:R:D163	R:R:P394	31.5878	6.44	Yes	No	0	9	9
19	R:R:N134	R:R:V137	14.8225	2.96	Yes	No	0	9	9
20	R:R:A398	R:R:V137	13.0375	3.39	No	No	0	7	9
21	R:R:A398	R:R:L404	11.2327	1.58	No	Yes	0	7	8
22	R:R:P151	R:R:R150	10.8678	1.44	Yes	No	1	5	5
23	R:R:P151	R:R:V228	28.6982	3.53	Yes	Yes	1	5	6
24	R:R:I216	R:R:V228	25.3057	3.07	No	Yes	0	5	6
25	R:R:I212	R:R:I216	26.4497	2.94	No	No	0	7	5
26	R:R:F208	R:R:I212	27.2091	7.54	No	No	0	7	7
27	R:R:F208	R:R:L286	28.8856	12.18	No	Yes	0	7	8
28	R:R:L286	R:R:V204	34.5464	2.98	Yes	No	0	8	7
29	R:R:V204	R:R:W356	35.3649	3.68	No	Yes	2	7	8
30	R:R:H154	R:R:P151	10.641	3.05	Yes	Yes	1	3	5
31	R:R:R214	R:R:Y397	49.9507	6.17	No	Yes	0	9	9
32	R:R:W241	W:W:?1	12.6726	2.89	Yes	Yes	0	9	0
33	R:R:I169	W:W:?1	28.2249	3.62	No	Yes	0	5	0
34	R:R:I169	R:R:V196	29.8718	3.07	No	No	0	5	7
35	R:R:F200	R:R:V196	31.7258	2.62	Yes	No	0	7	7
36	R:R:C386	R:R:F200	65.0986	4.19	No	Yes	0	7	7
37	R:R:C386	R:R:L359	66.5582	3.17	No	Yes	0	7	7
38	R:R:F200	R:R:W279	33.8462	2	Yes	No	0	7	6
39	R:R:T197	R:R:W279	24.6943	7.28	No	No	0	6	6
40	R:R:T197	R:R:Y275	20.789	3.75	No	Yes	0	6	7
41	R:R:R214	R:R:Y294	49.2899	7.2	No	Yes	0	9	9
42	R:R:L349	R:R:Y294	24.3393	10.55	No	Yes	0	8	9
43	R:R:L349	R:R:V291	24.211	1.49	No	No	0	8	5
44	R:R:L352	R:R:V291	23.856	1.49	No	No	0	9	5
45	R:R:L287	R:R:L352	24.3294	5.54	No	No	0	6	9
46	R:R:L287	R:R:W356	25.5128	4.56	No	Yes	0	6	8
47	R:R:V228	R:R:Y224	23.0868	2.52	Yes	Yes	1	6	7
48	R:R:K300	R:R:Y296	17.4359	5.97	Yes	Yes	3	5	4
49	R:R:I218	R:R:K300	51.5089	2.91	No	Yes	0	9	5
50	R:R:I218	R:R:I297	61.9625	4.42	No	No	0	9	9
51	R:R:I297	R:R:Y294	63.5404	2.42	No	Yes	0	9	9
52	R:R:S217	R:R:Y224	24.2604	5.09	No	Yes	0	8	7
53	R:R:I218	R:R:S217	25.3846	4.64	No	No	0	9	8
54	R:R:I280	R:R:L360	18.8067	5.71	Yes	No	0	5	7
55	R:R:A301	R:R:L341	17.5049	1.58	No	No	0	8	8
56	R:R:L341	R:R:M337	19.9408	1.41	No	No	0	8	6
57	R:R:H304	R:R:M337	22.0809	3.94	No	No	0	7	6
58	R:R:H304	R:R:R307	26.8442	1.13	No	No	0	7	4
59	R:R:R307	R:R:S303	29.1913	1.32	No	No	0	4	5
60	R:R:K300	R:R:S303	31.5187	1.53	Yes	No	0	5	5
61	R:R:A301	R:R:D338	15.0394	3.09	No	Yes	0	8	7
62	R:R:T391	R:R:V392	11.2327	3.17	Yes	No	0	7	6

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:A162	R:R:W241	2.59	0	No	Yes	8	9	2	1
R:R:L165	W:W:?1	8.19	0	No	Yes	6	0	1	0
R:R:G166	R:R:I169	3.53	0	No	No	8	5	2	1
R:R:I169	R:R:V196	3.07	0	No	No	5	7	1	2
R:R:I169	W:W:?1	3.62	0	No	Yes	5	0	1	0
R:R:F191	W:W:?1	28.84	0	No	Yes	5	0	1	0
R:R:G194	R:R:G195	2.11	7	No	No	6	4	1	1
R:R:G194	W:W:?1	2.89	7	No	Yes	6	0	1	0
R:R:G195	W:W:?1	13.02	7	No	Yes	4	0	1	0
R:R:A202	R:R:W241	7.78	0	No	Yes	7	9	2	1
R:R:F237	R:R:W241	6.01	0	No	Yes	8	9	2	1
R:R:W241	W:W:?1	2.89	0	Yes	Yes	9	0	1	0
R:R:I245	W:W:?1	9.66	0	No	Yes	4	0	1	0
R:R:A248	W:W:?1	4	0	No	Yes	7	0	1	0
R:R:A198	R:R:G195	1.95	0	No	No	5	4	2	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	8IKH_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	2
Number of Linked Nodes	236
Number of Links	243
Number of Hubs	29
Number of Links mediated by Hubs	110
Number of Communities	8
Number of Nodes involved in Communities	36
Number of Links involved in Communities	43

Path Summary
Number Of Nodes in MetaPath	63
Number Of Links MetaPath	62
Number of Shortest Paths	20187
Length Of Smallest Path	3
Average Path Length	13.9403
Length of Longest Path	29
Minimum Path Strength	1.225
Average Path Strength	4.42666
Maximum Path Strength	20.93
Minimum Path Correlation	0.7
Average Path Correlation	0.921137
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	4.7619
Average % Of Corr. Nodes	47.1097
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	36.4835
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process
Gene Ontology	Cellular Component
SCOP2	Domain Identifier	• G protein-coupled receptor-like • Transducin (heterotrimeric G protein), gamma chain • Ras-like P-loop GTPases
SCOP2	Family Identifier	• G protein-coupled receptor-like • Transducin (heterotrimeric G protein), gamma chain • Ras-like P-loop GTPases
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	Q2L
PDB Residues	W:W:?1
Environment Details	Open EMBL-EBI Page
Code	Q2L
Name	3-[(1R)-1-(2-methoxyphenyl)-2-nitro-ethyl]-2-phenyl-1H-indole
Synonyms
Identifier
Formula	C23 H20 N2 O3
Molecular Weight	372.417
SMILES
PubChem	171393541
Formal Charge	0
Total Atoms	48
Total Chiral Atoms	1
Total Bonds	51
Total Aromatic Bonds	22


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P21554
Sequence	>8IKH_nogp_Chain_R E C F M V L N P S Q Q L A I A V L S L T L G T F T V L E N L L V L C V I L H S R S L R C R P S Y H F I G S L A V A D L L G S V I F V Y S F I D F H R K D S R N V F L F K L G G V T A S F T A S V G S L F L T A I D R Y I S I H R P L A Y K R I V T R P K A V V A F C L M W T I A I V I A V L P L L G W N C I D E T Y L M F W I G V T S V L L L F I V Y A Y M Y I L W K A H S H A V R M I Q R G A R M D I R L A K T L V L I L V V L I I C W G P L L A I M V Y D V F G K M N K L I K T V F A F C S M L C L L N S T V N P I I Y A L R S K D L R H A F Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	7FEE	A	Lipid	Cannabinoid	CB₁	Homo sapiens	CP55940	ZCZ011	-	2.7	2022-06-15	doi.org/10.1038/s41589-022-01038-y
	7WV9	A	Lipid	Cannabinoid	CB₁	Homo sapiens	CP55940	ZCZ011	Gi2/β1/γ2	3.36	2022-06-15	doi.org/10.1038/s41589-022-01038-y
	7WV9 (No Gprot)	A	Lipid	Cannabinoid	CB₁	Homo sapiens	CP55940	ZCZ011		3.36	2022-06-15	doi.org/10.1038/s41589-022-01038-y
	8IKH	A	Lipid	Cannabinoid	CB₁	Homo sapiens	-	Q2L	Gi1/β1/γ1	3.3	2024-06-05	doi.org/10.1073/pnas.2321532121
	8IKH (No Gprot)	A	Lipid	Cannabinoid	CB₁	Homo sapiens	-	Q2L		3.3	2024-06-05	doi.org/10.1073/pnas.2321532121
	8IKG	A	Lipid	Cannabinoid	CB₁	Homo sapiens	-	Q2B	Gi1/β1/γ1	3.4	2024-06-05	doi.org/10.1073/pnas.2321532121
	8IKG (No Gprot)	A	Lipid	Cannabinoid	CB₁	Homo sapiens	-	Q2B		3.4	2024-06-05	doi.org/10.1073/pnas.2321532121
	6KQI	A	Lipid	Cannabinoid	CB₁	Homo sapiens	CP55940	Org27569	-	3.25	2019-10-23	doi.org/10.1038/s41589-019-0387-2
	8K8J	A	Lipid	Cannabinoid	CB₁	Homo sapiens	Fenofibrate	-	chim(Gs-CtGq)/β1/γ2	2.88	2024-02-14	doi.org/10.1002/advs.202306311
	8K8J (No Gprot)	A	Lipid	Cannabinoid	CB₁	Homo sapiens	Fenofibrate	-		2.88	2024-02-14	doi.org/10.1002/advs.202306311
	5TGZ	A	Lipid	Cannabinoid	CB₁	Homo sapiens	AM6538	-	-	2.8	2016-11-02	doi.org/10.1016/j.cell.2016.10.004
	6N4B	A	Lipid	Cannabinoid	CB₁	Homo sapiens	MDMB-Fubinaca	-	Gi1/β1/γ2	3	2019-01-30	doi.org/10.1016/j.cell.2018.11.040
	6N4B (No Gprot)	A	Lipid	Cannabinoid	CB₁	Homo sapiens	MDMB-Fubinaca	-		3	2019-01-30	doi.org/10.1016/j.cell.2018.11.040
	6KPG	A	Lipid	Cannabinoid	CB₁	Homo sapiens	AM841	-	Gi1/β1/γ2	3	2020-02-12	doi.org/10.1016/j.cell.2020.01.008
	6KPG (No Gprot)	A	Lipid	Cannabinoid	CB₁	Homo sapiens	AM841	-		3	2020-02-12	doi.org/10.1016/j.cell.2020.01.008
	7V3Z	A	Lipid	Cannabinoid	CB₁	Homo sapiens	CP55940	-	-	3.29	2021-11-24	doi.org/10.1021/jacs.1c06847
	5U09	A	Lipid	Cannabinoid	CB₁	Homo sapiens	Taranabant	-	-	2.6	2016-12-07	doi.org/10.1038/nature20613
	5XR8	A	Lipid	Cannabinoid	CB₁	Homo sapiens	AM841	-	-	2.95	2017-07-12	doi.org/10.1038/nature23272
	5XRA	A	Lipid	Cannabinoid	CB₁	Homo sapiens	AM11542	-	-	2.8	2017-07-12	doi.org/10.1038/nature23272
	8GHV	A	Lipid	Cannabinoid	CB₁	Homo sapiens	AMG315	-	Gi1/β1/γ2	2.8	2023-05-24	doi.org/10.1038/s41467-023-37864-4
	8GHV (No Gprot)	A	Lipid	Cannabinoid	CB₁	Homo sapiens	AMG315	-		2.8	2023-05-24	doi.org/10.1038/s41467-023-37864-4
	9B9Z	A	Lipid	Cannabinoid	CB₁	Homo sapiens	A1AKO	-	-	3.3	2024-11-20	doi.org/10.1038/s41467-024-54206-0
	9BA0	A	Lipid	Cannabinoid	CB₁	Homo sapiens	A1AKN	-	-	3.13	2024-11-20	doi.org/10.1038/s41467-024-54206-0
	9B9Y	A	Lipid	Cannabinoid	CB₁	Homo sapiens	7DY	-	-	3.5	2024-11-20	doi.org/10.1038/s41467-024-54206-0
	9B54	A	Lipid	Cannabinoid	CB₁	Homo sapiens	A1AIW	-	Gi1/β1/γ2	2.86	2025-03-05	doi.org/10.1038/s41586-025-08618-7
	9B54 (No Gprot)	A	Lipid	Cannabinoid	CB₁	Homo sapiens	A1AIW	-		2.86	2025-03-05	doi.org/10.1038/s41586-025-08618-7
	9B65	A	Lipid	Cannabinoid	CB₁	Homo sapiens	KCA	-	Gi1/β1/γ2	3.03	2025-03-05	doi.org/10.1038/s41586-025-08618-7
	9B65 (No Gprot)	A	Lipid	Cannabinoid	CB₁	Homo sapiens	KCA	-		3.03	2025-03-05	doi.org/10.1038/s41586-025-08618-7
	8WRZ	A	Lipid	Cannabinoid	CB₁	Homo sapiens	PubChem 102336704	-	Arrestin2	3.6	2024-02-28	doi.org/10.1093/procel/pwad055
	9ERX	A	Lipid	Cannabinoid	CB₁	Homo sapiens	D9-THC analog	-	Gi1/β1/γ2	2.9	2024-06-26	doi.org/10.21203/rs.3.rs-4277209/v1
	9ERX (No Gprot)	A	Lipid	Cannabinoid	CB₁	Homo sapiens	D9-THC analog	-		2.9	2024-06-26	doi.org/10.21203/rs.3.rs-4277209/v1
	8WU1	A	Lipid	Cannabinoid	CB₁	Homo sapiens	PubChem 119025665	-	Arrestin2	3.2	2024-03-20	doi.org/10.1016/j.cell.2023.11.017
	9DGI	A	Lipid	Cannabinoid	CB₁	Homo sapiens	Z8526711350	-	-	3.35	2025-04-30	doi.org/10.1038/s41467-025-57136-7
	9EGO	A	Lipid	Cannabinoid	CB₁	Homo sapiens	YVF	-	Gi1/β1/γ2	3.2	2025-04-30	doi.org/10.1038/s41467-025-57136-7
	9EGO (No Gprot)	A	Lipid	Cannabinoid	CB₁	Homo sapiens	YVF	-		3.2	2025-04-30	doi.org/10.1038/s41467-025-57136-7
	8GAG	A	Lipid	Cannabinoid	CB₁	Homo sapiens	PubChem 170838490	-	Gi1/β1/γ2	3.3	2024-02-28	To be published
	8GAG (No Gprot)	A	Lipid	Cannabinoid	CB₁	Homo sapiens	PubChem 170838490	-		3.3	2024-02-28	To be published

You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download 8IKH_nogp.zip

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