psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	A:A:D9	A:A:L5	9.5	No	No	0	4	2
2	A:A:K10	A:A:L5	4.23	No	No	0	3	2
3	A:A:K17	A:A:V13	4.55	No	No	0	4	3
4	A:A:V13	B:B:N88	2.96	No	No	0	3	7
5	A:A:R15	B:B:H91	3.39	No	No	0	5	5
6	A:A:S16	B:B:N88	4.47	No	No	0	7	7
7	A:A:S16	B:B:K89	3.06	No	Yes	0	7	9
8	A:A:I19	B:B:K89	5.82	No	Yes	0	9	9
9	A:A:D20	B:B:K89	12.44	No	Yes	0	6	9
10	A:A:L23	B:B:I80	2.85	No	Yes	0	6	8
11	A:A:E28	A:A:K29	5.4	No	No	0	4	1
12	A:A:R32	R:R:R226	9.6	No	No	0	4	4
13	A:A:E33	A:A:H188	3.69	No	No	1	6	6
14	A:A:E33	A:A:H195	7.39	No	No	0	6	4
15	A:A:E33	A:A:K197	12.15	No	No	1	6	7
16	A:A:L36	A:A:V34	2.98	No	Yes	6	7	5
17	A:A:L194	A:A:V34	4.47	No	Yes	6	3	5
18	A:A:F196	A:A:V34	7.87	Yes	Yes	6	4	5
19	A:A:T219	A:A:V34	4.76	No	Yes	0	9	5
20	A:A:F199	A:A:K35	4.96	Yes	No	0	7	9
21	A:A:K35	A:A:V218	4.55	No	No	0	9	5
22	A:A:F196	A:A:L36	3.65	Yes	No	6	4	7
23	A:A:I222	A:A:L36	2.85	No	No	0	8	7
24	A:A:L37	A:A:L39	2.77	No	No	1	9	9
25	A:A:F215	A:A:L37	7.31	Yes	No	1	7	9
26	A:A:I221	A:A:L37	4.28	Yes	No	1	8	9
27	A:A:L38	A:A:M198	7.07	No	No	0	8	6
28	A:A:D200	A:A:L38	4.07	No	No	0	5	8
29	A:A:I222	A:A:L38	2.85	No	No	0	8	8
30	A:A:I221	A:A:L39	4.28	Yes	No	1	8	9
31	A:A:I253	A:A:L39	8.56	No	No	1	7	9
32	A:A:G40	A:A:K46	3.49	No	No	0	9	9
33	A:A:F223	A:A:G40	3.01	Yes	No	0	7	9
34	A:A:A41	A:A:S44	3.42	No	No	0	7	9
35	A:A:E43	A:A:R242	15.12	No	Yes	0	9	9
36	A:A:A226	A:A:S44	3.42	No	No	0	7	9
37	A:A:G45	A:A:T48	5.46	No	No	0	9	9
38	A:A:D200	A:A:K46	6.91	No	No	0	5	9
39	A:A:I49	A:A:Q52	2.74	No	No	0	9	9
40	A:A:N331	A:A:Q52	7.92	Yes	No	0	4	9
41	A:A:F189	A:A:M53	6.22	Yes	No	6	3	9
42	A:A:M198	A:A:M53	4.33	No	No	6	6	9
43	A:A:M53	A:A:V332	3.04	No	No	6	9	8
44	A:A:G183	A:A:T182	3.64	No	No	0	7	9
45	A:A:F199	A:A:I184	3.77	Yes	No	1	7	9
46	A:A:I184	A:A:V201	4.61	No	No	1	9	9
47	A:A:F215	A:A:I184	2.51	Yes	No	1	7	9
48	A:A:E186	A:A:F199	10.49	No	Yes	0	5	7
49	A:A:F189	A:A:T187	5.19	Yes	No	0	3	9
50	A:A:H188	A:A:K197	11.79	No	No	1	6	7
51	A:A:F189	A:A:M198	6.22	Yes	No	6	3	6
52	A:A:H195	A:A:T190	4.11	No	No	0	4	9
53	A:A:F191	A:A:K192	7.44	Yes	No	6	3	5
54	A:A:F191	A:A:V332	6.55	Yes	No	6	3	8
55	A:A:F191	A:A:Q333	10.54	Yes	No	6	3	7
56	A:A:F191	A:A:F336	9.65	Yes	Yes	6	3	8
57	A:A:F336	A:A:K192	11.17	Yes	No	6	8	5
58	A:A:F196	A:A:L194	4.87	Yes	No	6	4	3
59	A:A:F336	A:A:L194	3.65	Yes	No	6	8	3
60	A:A:F196	A:A:V339	7.87	Yes	No	0	4	6
61	A:A:F199	A:A:K197	3.72	Yes	No	1	7	7
62	A:A:F199	A:A:F215	4.29	Yes	Yes	1	7	7
63	A:A:D200	A:A:G202	3.35	No	No	0	5	9
64	A:A:V201	A:A:W211	7.36	No	Yes	1	9	9
65	A:A:F215	A:A:V201	2.62	Yes	No	1	7	9
66	A:A:Q204	A:A:S206	7.22	Yes	No	1	9	9
67	A:A:Q204	A:A:W211	5.48	Yes	Yes	1	9	9
68	A:A:Q204	B:B:L117	3.99	Yes	No	0	9	9
69	A:A:Q204	B:B:Y145	5.64	Yes	Yes	1	9	8
70	A:A:S206	B:B:Y145	5.09	No	Yes	1	9	8
71	A:A:S206	B:B:D186	4.42	No	Yes	1	9	9
72	A:A:E207	B:B:D186	10.39	No	Yes	1	8	9
73	A:A:E207	B:B:C204	6.08	No	Yes	1	8	7
74	A:A:R208	A:A:W211	3	Yes	Yes	1	9	9
75	A:A:L249	A:A:R208	4.86	No	Yes	1	5	9
76	A:A:I253	A:A:R208	2.51	No	Yes	1	7	9
77	A:A:I212	A:A:K209	2.91	No	No	0	9	9
78	A:A:H213	A:A:K209	6.55	No	No	5	8	9
79	A:A:K209	A:A:W258	6.96	No	Yes	5	9	4
80	A:A:K210	B:B:Y145	3.58	Yes	Yes	1	8	8
81	A:A:K210	B:B:M188	7.2	Yes	Yes	1	8	8
82	A:A:K210	B:B:C204	3.23	Yes	Yes	1	8	7
83	A:A:K210	B:B:D228	9.68	Yes	Yes	1	8	9
84	A:A:K210	B:B:N230	4.2	Yes	No	1	8	9
85	A:A:K210	B:B:D246	4.15	Yes	Yes	1	8	9
86	A:A:F215	A:A:W211	5.01	Yes	Yes	1	7	9
87	A:A:F259	A:A:I212	5.02	Yes	No	0	5	9
88	A:A:H213	A:A:W258	11.64	No	Yes	5	8	4
89	A:A:C214	B:B:Y59	5.38	No	No	0	8	8
90	A:A:F215	A:A:V218	2.62	Yes	No	0	7	5
91	A:A:E216	A:A:W258	7.63	No	Yes	0	9	4
92	A:A:E216	B:B:K57	2.7	No	No	0	9	9
93	A:A:A220	A:A:I265	3.25	No	Yes	0	7	6
94	A:A:F259	A:A:I221	10.05	Yes	Yes	1	5	8
95	A:A:I221	A:A:T262	3.04	Yes	No	1	8	4
96	A:A:F267	A:A:I222	2.51	Yes	No	0	9	8
97	A:A:F223	A:A:V225	2.62	Yes	Yes	0	7	7
98	A:A:F223	A:A:L249	7.31	Yes	No	0	7	5
99	A:A:F223	A:A:F250	16.08	Yes	Yes	0	7	9
100	A:A:C224	A:A:F267	2.79	No	Yes	0	9	9
101	A:A:L266	A:A:V225	2.98	Yes	Yes	4	8	7
102	A:A:L268	A:A:V225	2.98	Yes	Yes	4	9	7
103	A:A:F307	A:A:V225	5.24	Yes	Yes	4	5	7
104	A:A:A226	A:A:D229	6.18	No	No	21	7	9
105	A:A:A226	A:A:R242	4.15	No	Yes	21	7	9
106	A:A:L227	A:A:L268	9.69	No	Yes	0	8	9
107	A:A:I303	A:A:L227	4.28	No	No	0	6	8
108	A:A:K270	A:A:S228	4.59	No	No	0	9	7
109	A:A:D229	A:A:R242	20.25	No	Yes	21	9	9
110	A:A:D229	A:A:M243	8.32	No	Yes	0	9	9
111	A:A:M243	A:A:Y230	3.59	Yes	Yes	0	9	8
112	A:A:K277	A:A:Y230	4.78	No	Yes	10	5	8
113	A:A:S281	A:A:Y230	2.54	No	Yes	10	1	8
114	A:A:P282	A:A:Y230	6.95	No	Yes	0	7	8
115	A:A:L283	A:A:Y230	4.69	Yes	Yes	10	5	8
116	A:A:C286	A:A:Y230	8.06	No	Yes	0	3	8
117	A:A:D231	A:A:K277	4.15	No	No	0	8	5
118	A:A:L232	A:A:N241	5.49	No	Yes	0	9	6
119	A:A:L232	A:A:R242	9.72	No	Yes	0	9	9
120	A:A:N241	A:A:V233	5.91	Yes	No	0	6	8
121	A:A:M243	A:A:N241	4.21	Yes	Yes	0	9	6
122	A:A:H244	A:A:N241	7.65	No	Yes	0	8	6
123	A:A:I303	A:A:M243	2.92	No	Yes	0	6	9
124	A:A:F307	A:A:M243	3.73	Yes	Yes	0	5	9
125	A:A:F307	A:A:M247	2.49	Yes	No	0	5	9
126	A:A:L310	A:A:M247	2.83	No	No	0	4	9
127	A:A:I253	A:A:L249	4.28	No	No	1	7	5
128	A:A:C254	A:A:F250	2.79	Yes	Yes	4	8	9
129	A:A:F250	A:A:I264	2.51	Yes	No	4	9	7
130	A:A:F250	A:A:L266	4.87	Yes	Yes	4	9	8
131	A:A:F250	A:A:I319	3.77	Yes	Yes	4	9	4
132	A:A:D251	A:A:N255	5.39	No	No	0	9	5
133	A:A:D251	A:A:L310	5.43	No	No	0	9	4
134	A:A:C254	A:A:I264	3.27	Yes	No	4	8	7
135	A:A:C254	A:A:N311	4.72	Yes	Yes	4	8	4
136	A:A:C254	A:A:K317	3.23	Yes	Yes	4	8	3
137	A:A:K312	A:A:N255	9.79	No	No	0	8	5
138	A:A:F259	A:A:N256	6.04	Yes	No	0	5	8
139	A:A:K257	A:A:W258	8.12	No	Yes	0	8	4
140	A:A:W258	B:B:R314	3	Yes	Yes	5	4	8
141	A:A:W258	B:B:W332	3.75	Yes	Yes	5	4	9
142	A:A:F259	A:A:T262	10.38	Yes	No	1	5	4
143	A:A:R313	A:A:T260	6.47	No	No	0	5	9
144	A:A:D261	A:A:T262	5.78	No	No	0	3	4
145	A:A:S263	A:A:V342	4.85	No	No	0	7	8
146	A:A:I264	A:A:K317	2.91	No	Yes	4	7	3
147	A:A:F267	A:A:I265	3.77	Yes	Yes	7	9	6
148	A:A:F334	A:A:I265	2.51	Yes	Yes	7	5	6
149	A:A:A338	A:A:I265	3.25	No	Yes	0	4	6
150	A:A:L266	A:A:L268	8.3	Yes	Yes	4	8	9
151	A:A:F307	A:A:L266	3.65	Yes	Yes	4	5	8
152	A:A:I319	A:A:L266	2.85	Yes	Yes	4	4	8
153	A:A:F267	A:A:H322	3.39	Yes	Yes	7	9	5
154	A:A:F267	A:A:T324	2.59	Yes	Yes	7	9	4
155	A:A:F267	A:A:F334	3.22	Yes	Yes	7	9	5
156	A:A:L268	A:A:Q304	2.66	Yes	Yes	4	9	7
157	A:A:L268	A:A:T321	2.95	Yes	No	4	9	7
158	A:A:F323	A:A:L268	4.87	Yes	Yes	4	9	9
159	A:A:K270	A:A:N269	8.39	No	No	0	9	8
160	A:A:N269	A:A:T324	4.39	No	Yes	0	8	4
161	A:A:F323	A:A:K271	8.69	Yes	No	0	9	9
162	A:A:C325	A:A:K271	6.47	No	No	0	9	9
163	A:A:D272	A:A:L273	6.79	No	No	0	5	9
164	A:A:D272	A:A:E276	3.9	No	No	0	5	5
165	A:A:E275	A:A:I278	2.73	No	No	0	9	9
166	A:A:E275	A:A:Y296	6.73	No	No	0	9	5
167	A:A:K277	A:A:S281	4.59	No	No	10	5	1
168	A:A:I278	A:A:N294	2.83	No	No	0	9	3
169	A:A:L283	A:A:Y287	5.86	Yes	Yes	10	5	6
170	A:A:L283	A:A:Y290	4.69	Yes	Yes	10	5	6
171	A:A:T284	A:A:Y290	2.5	No	Yes	0	7	6
172	A:A:C286	A:A:Y287	5.38	No	Yes	0	3	6
173	A:A:Y287	A:A:Y290	3.97	Yes	Yes	10	6	6
174	A:A:Y287	A:A:Y302	11.91	Yes	No	10	6	3
175	A:A:I303	A:A:Y287	7.25	No	Yes	0	6	6
176	A:A:Q306	A:A:Y287	9.02	No	Yes	10	3	6
177	A:A:G292	A:A:Y290	4.35	No	Yes	0	3	6
178	A:A:Y290	A:A:Y302	8.94	Yes	No	10	6	3
179	A:A:S293	A:A:T295	3.2	No	Yes	15	7	3
180	A:A:E298	A:A:S293	10.06	No	No	15	4	7
181	A:A:T295	A:A:Y296	2.5	Yes	No	15	3	5
182	A:A:E297	A:A:T295	5.64	No	Yes	15	4	3
183	A:A:E298	A:A:T295	4.23	No	Yes	15	4	3
184	A:A:E297	A:A:Y296	4.49	No	No	15	4	5
185	A:A:E297	A:A:E298	2.54	No	No	15	4	4
186	A:A:A300	A:A:F323	2.77	No	Yes	0	7	9
187	A:A:Q306	A:A:Y302	19.16	No	No	10	3	3
188	A:A:E308	A:A:Q304	5.1	No	Yes	0	8	7
189	A:A:Q304	A:A:T321	12.76	Yes	No	4	7	7
190	A:A:F323	A:A:Q304	5.86	Yes	Yes	4	9	7
191	A:A:E308	A:A:I319	6.83	No	Yes	0	8	4
192	A:A:K314	A:A:N311	2.8	No	Yes	0	4	4
193	A:A:K317	A:A:N311	2.8	Yes	Yes	4	3	4
194	A:A:I319	A:A:N311	4.25	Yes	Yes	4	4	4
195	A:A:D315	A:A:T316	8.67	No	No	0	3	3
196	A:A:E318	A:A:Y320	4.49	No	No	0	7	5
197	A:A:A338	A:A:Y320	2.67	No	No	0	4	5
198	A:A:D341	A:A:Y320	5.75	Yes	No	0	6	5
199	A:A:F323	A:A:T321	2.59	Yes	No	4	9	7
200	A:A:H322	A:A:T324	2.74	Yes	Yes	7	5	4
201	A:A:H322	A:A:K330	2.62	Yes	No	0	5	9
202	A:A:H322	A:A:N331	2.55	Yes	Yes	7	5	4
203	A:A:F334	A:A:H322	18.1	Yes	Yes	7	5	5
204	A:A:D328	A:A:T324	4.34	Yes	Yes	7	8	4
205	A:A:N331	A:A:T324	5.85	Yes	Yes	7	4	4
206	A:A:C325	A:A:D328	9.34	No	Yes	0	9	8
207	A:A:D328	A:A:K330	4.15	Yes	No	0	8	9
208	A:A:D328	A:A:N331	9.42	Yes	Yes	7	8	4
209	A:A:K330	A:A:Q333	2.71	No	No	0	9	7
210	A:A:Q333	A:A:V332	2.87	No	No	6	7	8
211	A:A:F334	R:R:R311	4.28	Yes	No	7	5	5
212	A:A:F334	R:R:T313	2.59	Yes	No	7	5	3
213	A:A:D337	A:A:F336	4.78	No	Yes	0	8	8
214	A:A:F336	A:A:T340	7.78	Yes	No	0	8	8
215	A:A:D337	R:R:R311	13.1	No	No	0	8	5
216	A:A:I344	A:A:T340	3.04	No	No	0	7	8
217	A:A:D341	A:A:K345	12.44	Yes	No	0	6	6
218	A:A:D341	R:R:H304	6.3	Yes	Yes	7	6	7
219	A:A:D341	R:R:M308	6.93	Yes	No	7	6	7
220	A:A:N346	A:A:V342	4.43	No	No	0	5	8
221	A:A:I343	R:R:L222	2.85	No	No	0	7	7
222	A:A:I344	R:R:P221	6.77	No	No	0	7	8
223	A:A:I344	R:R:H304	3.98	No	Yes	0	7	7
224	A:A:N347	R:R:Y224	12.79	No	Yes	0	4	7
225	A:A:L348	A:A:L353	4.15	No	Yes	0	8	8
226	A:A:F354	A:A:L348	8.53	Yes	No	0	7	8
227	A:A:L348	R:R:I218	4.28	No	No	0	8	9
228	A:A:D350	R:R:R150	4.76	No	No	0	5	5
229	A:A:D350	R:R:K225	5.53	No	No	0	5	4
230	A:A:C351	A:A:L353	3.17	Yes	Yes	8	4	8
231	A:A:C351	R:R:R214	5.57	Yes	Yes	8	4	9
232	A:A:C351	R:R:S217	6.89	Yes	No	0	4	8
233	A:A:G352	R:R:S401	3.71	No	No	0	4	8
234	A:A:L353	R:R:R214	12.15	Yes	Yes	8	8	9
235	A:A:L353	R:R:L341	4.15	Yes	No	0	8	8
236	A:A:F354	R:R:M337	2.49	Yes	No	0	7	6
237	A:A:F354	R:R:R340	5.34	Yes	No	0	7	7
238	A:A:F354	R:R:L341	6.09	Yes	No	0	7	8
239	B:B:E3	B:B:L4	3.98	No	No	0	5	4
240	B:B:E3	G:G:I9	4.1	No	No	0	5	2
241	B:B:L4	B:B:R8	3.64	No	No	0	4	3
242	B:B:L7	G:G:A12	4.73	No	No	0	8	5
243	B:B:L7	G:G:R13	6.07	No	No	0	8	6
244	B:B:E12	B:B:Q9	2.55	No	No	0	4	3
245	B:B:E10	B:B:Q13	14.02	No	No	19	8	1
246	B:B:E10	B:B:L14	3.98	No	Yes	19	8	8
247	B:B:E12	B:B:N16	10.52	No	No	0	4	1
248	B:B:L14	B:B:Q13	3.99	Yes	No	19	8	1
249	B:B:Q13	B:B:Q17	5.12	No	No	19	1	4
250	B:B:L14	B:B:Q17	6.65	Yes	No	19	8	4
251	B:B:L14	G:G:L19	5.54	Yes	No	0	8	9
252	B:B:Q17	G:G:A23	3.03	No	No	0	4	8
253	B:B:D20	B:B:R19	8.34	No	No	0	2	4
254	B:B:D27	B:B:Q259	5.22	No	No	0	8	6
255	B:B:D27	G:G:K29	2.77	No	No	0	8	4
256	B:B:D27	G:G:V30	2.92	No	No	0	8	8
257	B:B:Q32	B:B:T29	4.25	No	No	0	1	3
258	B:B:L30	B:B:T34	2.95	Yes	No	0	5	5
259	B:B:L261	B:B:L30	4.15	No	Yes	23	5	5
260	B:B:L30	B:B:M262	4.24	Yes	Yes	23	5	4
261	B:B:L30	G:G:A34	4.73	Yes	No	0	5	6
262	B:B:M262	B:B:S31	6.13	Yes	No	0	4	1
263	B:B:I33	B:B:Q32	2.74	No	No	0	3	1
264	B:B:N35	B:B:N36	8.17	No	No	0	1	1
265	B:B:D38	B:B:I37	4.2	No	No	0	1	2
266	B:B:I37	B:B:K301	2.91	No	No	0	2	5
267	B:B:R283	B:B:V40	5.23	Yes	No	16	9	3
268	B:B:D298	B:B:V40	8.76	No	No	16	9	3
269	B:B:I43	B:B:M45	4.37	No	No	0	3	4
270	B:B:L308	B:B:M45	2.83	No	No	0	7	4
271	B:B:M45	B:B:N340	2.8	No	No	0	4	9
272	B:B:R46	B:B:R48	5.33	No	No	0	5	7
273	B:B:K337	B:B:T47	6.01	Yes	No	9	6	3
274	B:B:T47	B:B:W339	4.85	No	Yes	9	3	9
275	B:B:N340	B:B:R48	4.82	No	No	2	9	7
276	B:B:R48	G:G:F61	3.21	No	Yes	2	7	8
277	B:B:I338	B:B:R49	5.01	Yes	No	2	5	7
278	B:B:R49	G:G:F61	7.48	No	Yes	2	7	8
279	B:B:R49	G:G:E63	4.65	No	No	0	7	6
280	B:B:R52	B:B:T50	7.76	No	No	0	7	3
281	B:B:K337	B:B:T50	4.5	Yes	No	0	6	3
282	B:B:L51	B:B:W82	25.06	Yes	Yes	2	9	9
283	B:B:L51	B:B:T87	4.42	Yes	No	0	9	5
284	B:B:L336	B:B:L51	4.15	No	Yes	2	7	9
285	B:B:I338	B:B:L51	5.71	Yes	Yes	2	5	9
286	B:B:H54	B:B:I58	5.3	Yes	Yes	0	9	9
287	B:B:H54	B:B:S72	8.37	Yes	No	2	9	9
288	B:B:H54	B:B:I80	9.28	Yes	Yes	2	9	8
289	B:B:H54	B:B:S334	2.79	Yes	No	0	9	4
290	B:B:K57	B:B:W332	18.57	No	Yes	0	9	9
291	B:B:C317	B:B:I58	3.27	No	Yes	0	7	9
292	B:B:G330	B:B:I58	3.53	No	Yes	0	5	9
293	B:B:I58	B:B:L336	2.85	Yes	No	0	9	7
294	B:B:W332	B:B:Y59	4.82	Yes	No	0	9	8
295	B:B:A60	B:B:C103	3.61	No	No	0	7	8
296	B:B:L70	B:B:M61	2.83	Yes	No	0	5	6
297	B:B:C317	B:B:M61	4.86	No	No	0	7	6
298	B:B:H62	B:B:Y105	3.27	No	Yes	0	6	6
299	B:B:H62	B:B:R150	9.03	No	No	0	6	6
300	B:B:L70	B:B:W63	12.53	Yes	Yes	0	5	7
301	B:B:S84	B:B:W63	4.94	Yes	Yes	0	5	7
302	B:B:G319	B:B:W63	2.81	No	Yes	0	5	7
303	B:B:T321	B:B:W63	9.7	No	Yes	0	7	7
304	B:B:A326	B:B:W63	2.59	No	Yes	0	7	7
305	B:B:A328	B:B:W63	3.89	No	Yes	0	5	7
306	B:B:G64	B:B:Y105	4.35	No	Yes	0	5	6
307	B:B:T65	B:B:Y105	2.5	No	Yes	0	1	6
308	B:B:D66	B:B:R68	3.57	No	Yes	0	8	5
309	B:B:D66	B:B:L69	2.71	No	No	0	8	5
310	B:B:S67	B:B:T321	6.4	No	No	0	5	7
311	B:B:D322	B:B:S67	4.42	No	No	0	1	5
312	B:B:D83	B:B:R68	5.96	No	Yes	0	8	5
313	B:B:R68	B:B:S84	2.64	Yes	Yes	2	5	5
314	B:B:R68	B:B:Y85	26.75	Yes	Yes	2	5	4
315	B:B:D83	B:B:L69	2.71	No	No	0	8	5
316	B:B:L69	B:B:Y105	3.52	No	Yes	0	5	6
317	B:B:L70	B:B:W82	4.56	Yes	Yes	0	5	9
318	B:B:I338	B:B:L70	2.85	Yes	Yes	0	5	5
319	B:B:L79	B:B:V71	4.47	Yes	No	0	7	8
320	B:B:I81	B:B:V71	3.07	No	No	0	7	8
321	B:B:V71	B:B:Y105	3.79	No	Yes	0	8	6
322	B:B:I80	B:B:S72	3.1	Yes	No	2	8	9
323	B:B:S72	B:B:W82	7.41	No	Yes	2	9	9
324	B:B:I93	B:B:L79	4.28	Yes	Yes	0	7	7
325	B:B:L79	B:B:V112	2.98	Yes	Yes	0	7	8
326	B:B:I80	B:B:W82	14.09	Yes	Yes	2	8	9
327	B:B:I81	B:B:V90	4.61	No	No	0	7	5
328	B:B:K89	B:B:W82	11.6	Yes	Yes	0	9	9
329	B:B:L336	B:B:W82	3.42	No	Yes	2	7	9
330	B:B:D83	B:B:T86	4.34	No	No	0	8	6
331	B:B:S84	B:B:Y85	2.54	Yes	Yes	2	5	4
332	B:B:S84	G:G:F61	6.61	Yes	Yes	2	5	8
333	B:B:Y85	G:G:P60	4.17	Yes	No	0	4	9
334	B:B:Y85	G:G:F61	5.16	Yes	Yes	2	4	8
335	B:B:N88	B:B:T86	7.31	No	No	0	7	6
336	B:B:H91	B:B:V133	11.07	No	No	0	5	4
337	B:B:I93	B:B:P94	3.39	Yes	No	0	7	5
338	B:B:I93	B:B:Y124	4.84	Yes	Yes	0	7	6
339	B:B:I93	B:B:V133	6.14	Yes	No	0	7	4
340	B:B:L117	B:B:M101	4.24	No	No	0	9	9
341	B:B:M101	B:B:Y145	3.59	No	Yes	0	9	8
342	B:B:C149	B:B:T102	5.07	No	No	0	8	8
343	B:B:A104	B:B:F151	2.77	No	Yes	0	7	9
344	B:B:G109	B:B:Y105	4.35	No	Yes	0	5	6
345	B:B:V112	B:B:Y105	2.52	Yes	Yes	0	8	6
346	B:B:A106	B:B:F151	4.16	No	Yes	0	6	9
347	B:B:N110	B:B:S108	7.45	No	No	0	4	6
348	B:B:D154	B:B:S108	5.89	No	No	0	6	6
349	B:B:N110	B:B:Y111	3.49	No	Yes	0	4	4
350	B:B:K127	B:B:N110	6.99	No	No	0	4	4
351	B:B:I123	B:B:Y111	3.63	Yes	Yes	0	6	4
352	B:B:N125	B:B:Y111	13.96	No	Yes	0	4	4
353	B:B:D154	B:B:Y111	6.9	No	Yes	0	6	4
354	B:B:V112	B:B:Y124	3.79	Yes	Yes	0	8	6
355	B:B:L126	B:B:V112	4.47	No	Yes	0	5	8
356	B:B:A113	B:B:F151	4.16	No	Yes	0	9	9
357	B:B:C114	B:B:Y124	6.72	No	Yes	0	8	6
358	B:B:D118	B:B:I120	11.2	No	No	0	9	6
359	B:B:H142	B:B:N119	3.83	Yes	No	0	9	9
360	B:B:G144	B:B:N119	5.09	No	No	0	8	9
361	B:B:E138	B:B:I120	2.73	No	No	0	6	6
362	B:B:A140	B:B:I120	3.25	No	No	0	5	6
363	B:B:C121	B:B:L139	4.76	No	No	0	8	9
364	B:B:S122	B:B:Y124	5.09	No	Yes	0	8	6
365	B:B:E138	B:B:S122	8.62	No	No	0	6	8
366	B:B:I123	B:B:R137	2.51	Yes	No	0	6	5
367	B:B:F151	B:B:I123	5.02	Yes	Yes	0	9	6
368	B:B:I123	B:B:I171	2.94	Yes	No	0	6	6
369	B:B:V135	B:B:Y124	5.05	No	Yes	0	4	6
370	B:B:N125	B:B:T128	5.85	No	No	24	4	3
371	B:B:N125	B:B:R134	6.03	No	No	24	4	3
372	B:B:L126	B:B:V133	2.98	No	No	0	5	4
373	B:B:R134	B:B:T128	2.59	No	No	24	3	3
374	B:B:E138	B:B:V135	4.28	No	No	0	6	4
375	B:B:L139	B:B:R137	3.64	No	No	0	9	5
376	B:B:G174	B:B:R137	4.5	No	No	0	4	5
377	B:B:L139	B:B:W169	11.39	No	Yes	0	9	8
378	B:B:H142	B:B:L146	2.57	Yes	No	14	9	7
379	B:B:H142	B:B:T159	5.48	Yes	Yes	14	9	9
380	B:B:H142	B:B:S161	12.55	Yes	No	0	9	9
381	B:B:A167	B:B:H142	2.93	No	Yes	14	4	9
382	B:B:H142	B:B:W169	4.23	Yes	Yes	14	9	8
383	B:B:D163	B:B:T143	10.12	No	No	0	9	5
384	B:B:S147	B:B:Y145	5.09	No	Yes	0	9	8
385	B:B:G162	B:B:Y145	4.35	No	Yes	1	9	8
386	B:B:D186	B:B:Y145	10.34	Yes	Yes	1	9	8
387	B:B:M188	B:B:Y145	3.59	Yes	Yes	1	8	8
388	B:B:L146	B:B:T159	2.95	No	Yes	14	7	9
389	B:B:C148	B:B:R150	6.96	No	No	0	6	6
390	B:B:C148	B:B:L190	3.17	No	Yes	0	6	5
391	B:B:C149	B:B:T159	3.38	No	Yes	0	8	9
392	B:B:F151	B:B:I157	5.02	Yes	No	0	9	7
393	B:B:D153	B:B:L152	5.43	No	Yes	25	5	3
394	B:B:L152	B:B:Q156	5.32	Yes	No	25	3	5
395	B:B:L152	B:B:L192	5.54	Yes	No	0	3	5
396	B:B:D153	B:B:Q156	3.92	No	No	25	5	5
397	B:B:D170	B:B:N155	6.73	Yes	No	26	9	3
398	B:B:I171	B:B:N155	2.83	No	No	0	6	3
399	B:B:E172	B:B:N155	2.63	No	No	26	6	3
400	B:B:L168	B:B:Q156	3.99	Yes	No	0	6	5
401	B:B:I157	B:B:W169	3.52	No	Yes	0	7	8
402	B:B:I157	B:B:I171	2.94	No	No	0	7	6
403	B:B:L168	B:B:V158	4.47	Yes	No	0	6	5
404	B:B:L190	B:B:V158	2.98	Yes	No	0	5	5
405	B:B:T159	B:B:W169	10.92	Yes	Yes	14	9	8
406	B:B:S160	B:B:V187	4.85	No	Yes	0	6	9
407	B:B:L190	B:B:S160	9.01	Yes	No	0	5	6
408	B:B:D186	B:B:G162	5.03	Yes	No	1	9	9
409	B:B:D163	B:B:T165	2.89	No	No	0	9	7
410	B:B:T165	B:B:T181	3.14	No	No	0	7	2
411	B:B:C166	B:B:F180	2.79	Yes	Yes	0	8	7
412	B:B:C166	B:B:V187	3.42	Yes	Yes	12	8	9
413	B:B:C166	B:B:F199	5.59	Yes	Yes	12	8	9
414	B:B:C166	B:B:S201	3.44	Yes	Yes	12	8	9
415	B:B:A167	B:B:W169	5.19	No	Yes	14	4	8
416	B:B:A167	B:B:Q176	4.55	No	No	14	4	4
417	B:B:L168	B:B:T177	2.95	Yes	No	0	6	4
418	B:B:L168	B:B:V213	2.98	Yes	No	0	6	4
419	B:B:Q176	B:B:W169	14.24	No	Yes	14	4	8
420	B:B:D170	B:B:E172	6.5	Yes	No	26	9	6
421	B:B:D170	B:B:T173	4.34	Yes	No	0	9	5
422	B:B:D170	B:B:T177	4.34	Yes	No	0	9	4
423	B:B:Q175	B:B:T173	2.83	No	No	0	4	5
424	B:B:Q176	B:B:T179	5.67	No	No	0	4	4
425	B:B:T177	B:B:T178	4.71	No	No	0	4	4
426	B:B:F180	B:B:T178	7.78	Yes	No	0	7	4
427	B:B:F180	B:B:W211	13.03	Yes	Yes	0	7	8
428	B:B:F180	B:B:G216	4.52	Yes	No	0	7	4
429	B:B:G182	B:B:T181	3.64	No	No	0	6	2
430	B:B:G185	B:B:T184	3.64	No	No	0	5	3
431	B:B:D205	B:B:T184	10.12	No	No	0	9	3
432	B:B:C204	B:B:D186	4.67	Yes	Yes	1	7	9
433	B:B:S201	B:B:V187	3.23	Yes	Yes	12	9	9
434	B:B:C204	B:B:M188	3.24	Yes	Yes	1	7	8
435	B:B:M188	B:B:N230	4.21	Yes	No	1	8	9
436	B:B:I232	B:B:S189	3.1	Yes	No	0	8	7
437	B:B:F199	B:B:L190	8.53	Yes	Yes	0	9	5
438	B:B:F234	B:B:S191	7.93	No	No	0	5	8
439	B:B:A193	B:B:D195	3.09	No	No	0	4	5
440	B:B:A193	B:B:F234	5.55	No	No	0	4	5
441	B:B:G238	B:B:P194	4.06	No	No	0	7	4
442	B:B:D195	B:B:R197	3.57	No	No	0	5	5
443	B:B:L198	B:B:R197	3.64	No	No	0	3	5
444	B:B:L198	B:B:L210	6.92	No	No	0	3	5
445	B:B:F199	B:B:S201	2.64	Yes	Yes	12	9	9
446	B:B:F199	B:B:W211	10.02	Yes	Yes	12	9	8
447	B:B:F199	B:B:V213	3.93	Yes	No	0	9	4
448	B:B:I232	B:B:V200	6.14	Yes	No	3	8	6
449	B:B:F234	B:B:V200	6.55	No	No	0	5	6
450	B:B:F241	B:B:V200	6.55	Yes	No	3	6	6
451	B:B:S201	B:B:W211	6.18	Yes	Yes	12	9	8
452	B:B:A203	B:B:D205	3.09	No	No	0	8	9
453	B:B:C204	B:B:D228	3.11	Yes	Yes	1	7	9
454	B:B:D205	B:B:S207	8.83	No	No	0	9	5
455	B:B:A206	B:B:E226	4.53	No	No	0	4	3
456	B:B:K209	B:B:W211	9.28	No	Yes	12	6	8
457	B:B:C218	B:B:K209	8.08	No	No	12	5	6
458	B:B:K209	B:B:T221	9.01	No	No	0	6	7
459	B:B:L210	B:B:Q220	3.99	No	Yes	0	5	7
460	B:B:L210	B:B:L255	9.69	No	No	0	5	6
461	B:B:C218	B:B:W211	7.84	No	Yes	12	5	8
462	B:B:D212	B:B:E215	11.69	No	No	20	9	3
463	B:B:D212	B:B:R219	13.1	No	No	20	9	5
464	B:B:E215	B:B:M217	4.06	No	No	20	3	3
465	B:B:E215	B:B:R219	10.47	No	No	20	3	5
466	B:B:M217	B:B:R219	9.93	No	No	20	3	5
467	B:B:M217	G:G:M21	2.89	No	No	0	3	1
468	B:B:F222	B:B:Q220	5.86	No	Yes	3	8	7
469	B:B:D258	B:B:Q220	13.05	Yes	Yes	3	7	7
470	B:B:Q220	G:G:I25	4.12	Yes	No	3	7	2
471	B:B:T221	G:G:E22	7.06	No	No	0	7	9
472	B:B:F222	B:B:F241	8.57	No	Yes	3	8	6
473	B:B:D258	B:B:F222	5.97	Yes	No	3	7	8
474	B:B:E226	B:B:G224	4.91	No	No	0	3	6
475	B:B:E226	B:B:R251	5.82	No	Yes	0	3	8
476	B:B:D228	B:B:S227	5.89	Yes	No	1	9	6
477	B:B:D246	B:B:S227	2.94	Yes	No	1	9	6
478	B:B:D228	B:B:D246	11.98	Yes	Yes	1	9	9
479	B:B:I229	B:B:T243	4.56	No	Yes	0	7	8
480	B:B:I229	B:B:S245	6.19	No	No	0	7	9
481	B:B:D246	B:B:N230	10.77	Yes	No	1	9	9
482	B:B:A231	B:B:V276	3.39	No	No	0	5	6
483	B:B:F241	B:B:I232	5.02	Yes	Yes	3	6	8
484	B:B:I232	B:B:T243	4.56	Yes	Yes	3	8	8
485	B:B:C233	B:B:F278	4.19	No	Yes	0	3	7
486	B:B:F235	B:B:P236	15.89	Yes	Yes	17	6	7
487	B:B:F235	B:B:F278	8.57	Yes	Yes	17	6	7
488	B:B:F235	B:B:G282	4.52	Yes	No	17	6	9
489	B:B:F235	G:G:L37	12.18	Yes	No	0	6	7
490	B:B:F235	G:G:Y40	5.16	Yes	Yes	17	6	6
491	B:B:F278	B:B:P236	2.89	Yes	Yes	17	7	7
492	B:B:G282	B:B:P236	4.06	No	Yes	17	9	7
493	B:B:P236	G:G:Y40	6.95	Yes	Yes	17	7	6
494	B:B:N237	G:G:Y40	9.3	No	Yes	0	5	6
495	B:B:N239	B:B:R256	8.44	No	No	0	2	9
496	B:B:A240	B:B:D254	3.09	No	No	0	6	9
497	B:B:F241	B:B:T243	2.59	Yes	Yes	3	6	8
498	B:B:F241	B:B:F253	9.65	Yes	Yes	3	6	6
499	B:B:F241	B:B:L255	3.65	Yes	No	0	6	6
500	B:B:A242	B:B:F278	2.77	No	Yes	0	4	7
501	B:B:F253	B:B:T243	9.08	Yes	Yes	3	6	8
502	B:B:G244	B:B:I273	3.53	No	No	0	5	6
503	B:B:D247	B:B:S245	4.42	No	No	0	9	9
504	B:B:D247	B:B:T249	8.67	No	Yes	0	9	6
505	B:B:R251	B:B:T249	7.76	Yes	Yes	3	8	6
506	B:B:T249	B:B:T263	3.14	Yes	No	3	6	1
507	B:B:S265	B:B:T249	4.8	No	Yes	0	2	6
508	B:B:C250	B:B:Y264	6.72	No	Yes	0	8	5
509	B:B:F253	B:B:R251	3.21	Yes	Yes	3	6	8
510	B:B:E260	B:B:R251	19.77	No	Yes	3	6	8
511	B:B:R251	B:B:T263	7.76	Yes	No	3	8	1
512	B:B:L252	B:B:L261	5.54	No	No	0	7	5
513	B:B:E260	B:B:F253	4.66	No	Yes	3	6	6
514	B:B:A257	B:B:D254	4.63	No	No	0	7	9
515	B:B:D254	G:G:A33	4.63	No	No	0	9	7
516	B:B:R256	G:G:D36	5.96	No	No	0	9	5
517	B:B:A257	G:G:V30	3.39	No	No	0	7	8
518	B:B:D258	G:G:I25	4.2	Yes	No	3	7	2
519	B:B:D258	G:G:R27	11.91	Yes	No	3	7	8
520	B:B:E260	B:B:T263	4.23	No	No	3	6	1
521	B:B:L261	B:B:M262	2.83	No	Yes	23	5	4
522	B:B:M262	B:B:Y264	8.38	Yes	Yes	0	4	5
523	B:B:L285	B:B:Y264	4.69	No	Yes	0	6	5
524	B:B:W297	B:B:Y264	3.86	Yes	Yes	0	8	5
525	B:B:H266	B:B:I269	2.65	No	No	0	4	4
526	B:B:C271	B:B:I269	3.27	Yes	No	5	5	4
527	B:B:I269	B:B:Y289	3.63	No	Yes	5	4	7
528	B:B:C271	B:B:Y289	5.38	Yes	Yes	5	5	7
529	B:B:C271	B:B:D290	6.22	Yes	Yes	5	5	6
530	B:B:C271	B:B:D291	9.34	Yes	No	0	5	8
531	B:B:D290	B:B:G272	3.35	Yes	No	0	6	4
532	B:B:I273	B:B:Y289	12.09	No	Yes	0	6	7
533	B:B:D290	B:B:T274	2.89	Yes	No	5	6	8
534	B:B:R314	B:B:T274	2.59	Yes	No	5	8	8
535	B:B:L318	B:B:S277	3	Yes	No	0	6	5
536	B:B:F278	B:B:L285	4.87	Yes	No	0	7	6
537	B:B:A299	B:B:F278	2.77	No	Yes	0	5	7
538	B:B:S279	G:G:L50	6.01	No	No	0	9	9
539	B:B:D323	B:B:K280	2.77	No	No	0	7	1
540	B:B:K280	G:G:E47	8.1	No	No	0	1	3
541	B:B:K280	G:G:D48	4.15	No	Yes	0	1	9
542	B:B:S281	G:G:D48	10.31	No	Yes	0	9	9
543	B:B:D298	B:B:R283	15.48	No	Yes	16	9	9
544	B:B:L300	B:B:R283	3.64	No	Yes	16	6	9
545	B:B:R283	G:G:C41	4.18	Yes	No	16	9	7
546	B:B:R283	G:G:L51	7.29	Yes	Yes	0	9	6
547	B:B:L284	B:B:V296	5.96	No	Yes	0	5	5
548	B:B:L284	G:G:L51	2.77	No	Yes	0	5	6
549	B:B:L286	B:B:V296	5.96	No	Yes	0	7	5
550	B:B:L286	B:B:L318	2.77	No	Yes	0	7	6
551	B:B:L286	B:B:V327	4.47	No	No	0	7	6
552	B:B:A287	B:B:Y289	2.67	No	Yes	5	6	7
553	B:B:A287	B:B:W297	2.59	No	Yes	5	6	8
554	B:B:C294	B:B:G288	3.92	Yes	No	0	5	7
555	B:B:N295	B:B:Y289	8.14	Yes	Yes	5	6	7
556	B:B:W297	B:B:Y289	9.65	Yes	Yes	5	8	7
557	B:B:D290	B:B:R314	11.91	Yes	Yes	5	6	8
558	B:B:D291	B:B:N293	2.69	No	No	0	8	5
559	B:B:N293	B:B:N295	4.09	No	Yes	0	5	6
560	B:B:N293	B:B:V307	2.96	No	No	0	5	3
561	B:B:C294	B:B:V315	5.12	Yes	No	9	5	7
562	B:B:C294	B:B:L318	3.17	Yes	Yes	9	5	6
563	B:B:C294	B:B:T329	3.38	Yes	Yes	9	5	8
564	B:B:N295	B:B:W297	5.65	Yes	Yes	5	6	8
565	B:B:N295	B:B:R304	8.44	Yes	No	0	6	5
566	B:B:L308	B:B:V296	2.98	No	Yes	0	7	5
567	B:B:D298	B:B:K301	8.3	No	No	0	9	5
568	B:B:L300	G:G:M38	2.83	No	No	0	6	4
569	B:B:L300	G:G:C41	6.35	No	No	16	6	7
570	B:B:D303	B:B:K301	6.91	No	No	0	2	5
571	B:B:R304	B:B:V307	3.92	No	No	0	5	3
572	B:B:L308	B:B:W339	4.56	No	Yes	0	7	9
573	B:B:H311	B:B:V315	4.15	Yes	No	9	9	7
574	B:B:H311	B:B:T329	4.11	Yes	Yes	9	9	8
575	B:B:G330	B:B:H311	3.18	No	Yes	0	5	9
576	B:B:H311	B:B:S331	16.74	Yes	No	9	9	9
577	B:B:D333	B:B:H311	7.56	Yes	Yes	9	9	9
578	B:B:H311	B:B:K337	3.93	Yes	Yes	9	9	6
579	B:B:N313	B:B:W332	9.04	No	Yes	0	7	9
580	B:B:D333	B:B:N313	2.69	Yes	No	0	9	7
581	B:B:R314	B:B:W332	22.99	Yes	Yes	5	8	9
582	B:B:S331	B:B:V315	6.46	No	No	9	9	7
583	B:B:S316	B:B:W332	7.41	No	Yes	0	9	9
584	B:B:L318	B:B:T329	2.95	Yes	Yes	9	6	8
585	B:B:V320	B:B:V327	8.02	No	No	0	7	6
586	B:B:M325	G:G:P49	5.03	No	No	0	5	7
587	B:B:M325	G:G:P60	6.71	No	No	0	5	9
588	B:B:A326	G:G:F61	4.16	No	Yes	0	7	8
589	B:B:V327	G:G:L50	4.47	No	No	0	6	9
590	B:B:T329	B:B:W339	7.28	Yes	Yes	9	8	9
591	B:B:D333	B:B:S331	4.42	Yes	No	9	9	9
592	B:B:D333	B:B:F335	3.58	Yes	No	0	9	4
593	B:B:K337	B:B:W339	9.28	Yes	Yes	9	6	9
594	B:B:I338	G:G:F61	3.77	Yes	Yes	2	5	8
595	B:B:N340	G:G:F61	4.83	No	Yes	2	9	8
596	G:G:L15	G:G:Q11	5.32	No	No	0	2	3
597	G:G:R13	G:G:V16	5.23	No	No	0	6	7
598	G:G:M21	G:G:Q18	4.08	No	No	0	1	9
599	G:G:E22	G:G:Q18	2.55	No	No	0	9	9
600	G:G:I25	G:G:R27	11.27	No	No	3	2	8
601	G:G:H44	G:G:Y40	8.71	No	Yes	0	6	6
602	G:G:A43	G:G:E42	4.53	No	No	0	4	1
603	G:G:A43	G:G:H44	2.93	No	No	0	4	6
604	G:G:E47	G:G:K46	13.5	No	No	0	3	1
605	G:G:D48	G:G:L51	12.21	Yes	Yes	0	9	6
606	G:G:P55	G:G:V54	3.53	No	No	0	5	6
607	G:G:P60	G:G:R62	4.32	No	No	0	9	7
608	R:R:I267	R:R:V110	3.07	No	No	0	4	3
609	R:R:K376	R:R:V110	3.04	No	No	0	2	3
610	R:R:L111	R:R:P113	3.28	No	No	0	4	2
611	R:R:K373	R:R:N112	8.39	No	No	0	3	6
612	R:R:K376	R:R:N112	8.39	No	No	0	2	6
613	R:R:P113	R:R:Q116	6.32	No	Yes	0	2	4
614	R:R:I119	R:R:Q116	8.23	No	Yes	27	5	4
615	R:R:A380	R:R:Q116	4.55	No	Yes	0	4	4
616	R:R:F381	R:R:Q116	11.71	No	Yes	27	4	4
617	R:R:F381	R:R:I119	2.51	No	No	27	4	5
618	R:R:T125	R:R:T128	3.14	No	No	0	4	5
619	R:R:L126	R:R:L387	4.15	No	No	0	6	7
620	R:R:L126	R:R:T391	2.95	No	Yes	0	6	7
621	R:R:G127	R:R:T130	3.64	No	Yes	0	6	7
622	R:R:F129	R:R:L132	4.87	No	No	0	4	3
623	R:R:E133	R:R:F129	3.5	Yes	No	0	8	4
624	R:R:E133	R:R:T130	2.82	Yes	Yes	28	8	7
625	R:R:S167	R:R:T130	4.8	No	Yes	0	7	7
626	R:R:T130	R:R:T391	7.85	Yes	Yes	28	7	7
627	R:R:L135	R:R:V131	2.98	No	No	29	3	6
628	R:R:L164	R:R:V131	4.47	No	No	29	7	6
629	R:R:S167	R:R:V131	3.23	No	No	0	7	6
630	R:R:E133	R:R:N134	3.94	Yes	Yes	0	8	9
631	R:R:E133	R:R:T391	7.06	Yes	Yes	28	8	7
632	R:R:E133	R:R:I395	8.2	Yes	No	0	8	6
633	R:R:L164	R:R:N134	2.75	No	Yes	0	7	9
634	R:R:N134	R:R:P394	4.89	Yes	No	0	9	9
635	R:R:L135	R:R:L164	2.77	No	No	29	3	7
636	R:R:L138	R:R:L142	6.92	No	No	0	7	4
637	R:R:L138	R:R:V161	2.98	No	No	0	7	6
638	R:R:I141	R:R:R148	5.01	No	No	0	7	8
639	R:R:I141	R:R:L404	2.85	No	No	0	7	8
640	R:R:L142	R:R:R148	7.29	No	No	0	4	8
641	R:R:R148	R:R:S144	3.95	No	No	0	8	6
642	R:R:C149	R:R:R230	4.18	No	No	0	7	1
643	R:R:R150	R:R:Y153	11.32	No	Yes	18	5	9
644	R:R:D403	R:R:R150	3.57	No	No	18	6	5
645	R:R:H154	R:R:P151	3.05	No	No	0	3	5
646	R:R:P151	R:R:V228	3.53	No	Yes	0	5	6
647	R:R:D213	R:R:S152	2.94	No	No	0	9	8
648	R:R:S401	R:R:Y153	5.09	No	Yes	18	8	9
649	R:R:D403	R:R:Y153	10.34	No	Yes	18	6	9
650	R:R:A233	R:R:H154	2.93	No	No	0	7	3
651	R:R:F155	R:R:L209	7.31	No	No	0	8	6
652	R:R:A233	R:R:F155	2.77	No	No	0	7	8
653	R:R:I156	R:R:Y397	4.84	No	Yes	0	8	9
654	R:R:S158	R:R:S206	4.89	No	No	0	9	8
655	R:R:F237	R:R:S158	6.61	No	No	30	8	9
656	R:R:S158	R:R:W241	6.18	No	Yes	30	9	9
657	R:R:D163	R:R:L159	5.43	No	Yes	0	9	9
658	R:R:L159	R:R:S203	3	Yes	No	0	9	9
659	R:R:L159	R:R:S206	3	Yes	No	0	9	8
660	R:R:L159	R:R:L207	5.54	Yes	No	8	9	8
661	R:R:L159	R:R:N393	5.49	Yes	No	8	9	9
662	R:R:A162	R:R:W241	2.59	No	Yes	0	8	9
663	R:R:D163	R:R:S390	11.78	No	No	0	9	9
664	R:R:D163	R:R:P394	4.83	No	No	0	9	9
665	R:R:I169	R:R:L165	4.28	Yes	No	0	5	6
666	R:R:L165	R:R:S199	6.01	No	No	0	6	7
667	R:R:G166	R:R:S199	3.71	No	No	0	8	7
668	R:R:I169	W:W:?1	7.94	Yes	Yes	0	5	0
669	R:R:F170	R:R:S383	3.96	No	No	0	7	6
670	R:R:I175	R:R:Y172	3.63	No	No	0	5	7
671	R:R:K192	R:R:S173	7.65	No	No	0	6	4
672	R:R:D176	R:R:F177	3.58	No	No	0	3	4
673	R:R:F177	R:R:H181	6.79	No	No	0	4	3
674	R:R:F177	R:R:F189	6.43	No	No	0	4	9
675	R:R:H178	R:R:V179	6.92	No	No	0	4	4
676	R:R:F180	R:R:R182	3.21	No	No	0	4	4
677	R:R:D184	R:R:R182	8.34	No	No	0	2	4
678	R:R:N187	R:R:S185	5.96	No	No	0	1	7
679	R:R:L190	R:R:R186	7.29	No	No	0	5	3
680	R:R:P269	R:R:R186	14.41	No	No	0	3	3
681	R:R:F189	R:R:F268	17.15	No	No	0	9	5
682	R:R:L190	R:R:L252	4.15	No	No	11	5	5
683	R:R:H270	R:R:L190	7.71	Yes	No	11	3	5
684	R:R:F191	W:W:?1	31.63	No	Yes	0	5	0
685	R:R:F268	R:R:L193	6.09	No	No	0	5	4
686	R:R:G194	W:W:?1	4.76	No	Yes	0	6	0
687	R:R:G195	W:W:?1	9.52	No	Yes	0	4	0
688	R:R:F200	R:R:V196	2.62	No	No	0	7	7
689	R:R:T197	R:R:W279	3.64	No	Yes	0	6	6
690	R:R:F200	R:R:W356	3.01	No	Yes	31	7	8
691	R:R:C386	R:R:F200	5.59	No	No	31	7	7
692	R:R:A202	R:R:W241	6.48	No	Yes	0	7	9
693	R:R:T283	R:R:V204	3.17	No	No	0	8	7
694	R:R:L286	R:R:V204	4.47	No	No	0	8	7
695	R:R:V204	R:R:W356	3.68	No	Yes	0	7	8
696	R:R:L207	R:R:N393	5.49	No	No	8	8	9
697	R:R:L207	R:R:Y397	3.52	No	Yes	8	8	9
698	R:R:F208	R:R:I212	10.05	Yes	No	0	7	7
699	R:R:F208	R:R:L286	8.53	Yes	No	0	7	8
700	R:R:F208	R:R:F289	5.36	Yes	No	0	7	6
701	R:R:F208	R:R:I290	3.77	Yes	No	0	7	8
702	R:R:A236	R:R:L209	3.15	No	No	0	5	6
703	R:R:L209	R:R:M240	4.24	No	No	0	6	6
704	R:R:R214	R:R:T210	2.59	Yes	No	8	9	9
705	R:R:T210	R:R:Y397	2.5	No	Yes	8	9	9
706	R:R:A211	R:R:I290	3.25	No	No	0	8	8
707	R:R:A211	R:R:Y294	4	No	Yes	0	8	9
708	R:R:D213	R:R:Y224	8.05	No	Yes	22	9	7
709	R:R:D213	R:R:V228	2.92	No	Yes	22	9	6
710	R:R:R214	R:R:Y294	7.2	Yes	Yes	8	9	9
711	R:R:R214	R:R:Y397	3.09	Yes	Yes	8	9	9
712	R:R:I216	R:R:Y215	3.63	No	No	0	5	8
713	R:R:H219	R:R:Y215	15.24	No	No	32	6	8
714	R:R:Y215	R:R:Y296	10.92	No	No	32	8	4
715	R:R:I218	R:R:S217	4.64	No	No	0	9	8
716	R:R:S217	R:R:Y224	5.09	No	Yes	0	8	7
717	R:R:I218	R:R:K300	2.91	No	No	0	9	5
718	R:R:H219	R:R:R220	9.03	No	No	0	6	5
719	R:R:H219	R:R:Y296	4.36	No	No	32	6	4
720	R:R:A223	R:R:R226	2.77	No	No	0	5	4
721	R:R:A223	R:R:I227	3.25	No	No	0	5	4
722	R:R:V228	R:R:Y224	3.79	Yes	Yes	22	6	7
723	R:R:P231	R:R:T229	6.99	No	No	0	4	8
724	R:R:F237	R:R:W241	5.01	No	Yes	30	8	9
725	R:R:I243	R:R:M240	2.92	No	No	0	5	6
726	R:R:I247	R:R:Y275	3.63	No	No	0	5	7
727	R:R:F278	R:R:I247	2.51	No	No	0	6	5
728	R:R:A248	W:W:?1	4.38	No	Yes	0	7	0
729	R:R:L252	R:R:V249	2.98	No	No	0	5	5
730	R:R:V249	W:W:?1	2.76	No	Yes	0	5	0
731	R:R:L250	R:R:P251	4.93	No	No	0	5	6
732	R:R:H270	R:R:P251	7.63	Yes	No	0	3	6
733	R:R:P251	R:R:Y275	15.3	No	No	0	6	7
734	R:R:H270	R:R:L252	2.57	Yes	No	11	3	5
735	R:R:H270	R:R:N256	5.1	Yes	No	11	3	6
736	R:R:D272	R:R:N256	6.73	No	No	11	5	6
737	R:R:C257	R:R:C264	7.28	No	No	11	9	9
738	R:R:C257	R:R:I271	3.27	No	Yes	11	9	3
739	R:R:C264	R:R:I271	11.46	No	Yes	11	9	3
740	R:R:D266	R:R:I271	2.8	No	Yes	0	4	3
741	R:R:F268	R:R:I267	13.82	No	No	0	5	4
742	R:R:D272	R:R:H270	2.52	No	Yes	11	5	3
743	R:R:E273	R:R:I271	5.47	No	Yes	0	3	3
744	R:R:E273	R:R:L276	3.98	No	No	0	3	5
745	R:R:I280	R:R:L276	2.85	Yes	No	13	5	5
746	R:R:L276	R:R:M363	2.83	No	Yes	13	5	6
747	R:R:F278	R:R:V282	7.87	No	No	0	6	6
748	R:R:I280	R:R:W279	3.52	Yes	Yes	13	5	6
749	R:R:T283	R:R:W279	3.64	No	Yes	0	8	6
750	R:R:M363	R:R:W279	3.49	Yes	Yes	13	6	6
751	R:R:I280	R:R:L360	4.28	Yes	No	0	5	7
752	R:R:I280	R:R:M363	4.37	Yes	Yes	13	5	6
753	R:R:F289	R:R:V285	3.93	No	No	0	6	6
754	R:R:L287	R:R:L352	5.54	No	No	0	6	9
755	R:R:L287	R:R:W356	4.56	No	Yes	0	6	8
756	R:R:I290	R:R:L352	2.85	No	No	0	8	9
757	R:R:L349	R:R:V291	4.47	No	No	0	8	5
758	R:R:L345	R:R:Y294	4.69	Yes	Yes	0	8	9
759	R:R:I348	R:R:Y294	3.63	No	Yes	8	8	9
760	R:R:L349	R:R:Y294	5.86	No	Yes	0	8	9
761	R:R:Y294	R:R:Y397	4.96	Yes	Yes	8	9	9
762	R:R:W299	R:R:Y296	4.82	No	No	0	3	4
763	R:R:I297	R:R:L345	2.85	No	Yes	0	9	8
764	R:R:L298	R:R:L345	11.07	No	Yes	0	6	8
765	R:R:K300	R:R:W299	3.48	No	No	0	5	3
766	R:R:D338	R:R:H302	13.87	No	No	0	7	5
767	R:R:H304	R:R:M308	3.94	Yes	No	7	7	7
768	R:R:H304	R:R:M337	2.63	Yes	No	0	7	6
769	R:R:M308	R:R:T313	3.01	No	No	7	7	3
770	R:R:R311	R:R:T313	10.35	No	No	7	5	3
771	R:R:R336	R:R:R340	5.33	No	No	0	4	7
772	R:R:I339	R:R:K343	4.36	No	No	0	5	7
773	R:R:L345	R:R:T344	2.95	Yes	No	0	8	8
774	R:R:R400	R:R:T344	10.35	No	No	0	7	8
775	R:R:I396	R:R:L347	5.71	No	No	0	9	7
776	R:R:L347	R:R:R400	3.64	No	No	0	7	7
777	R:R:I348	R:R:I396	2.94	No	No	0	8	9
778	R:R:I348	R:R:Y397	3.63	No	Yes	8	8	9
779	R:R:C355	R:R:N389	7.87	No	No	0	8	9
780	R:R:L360	R:R:W356	4.56	No	Yes	0	7	8
781	R:R:C386	R:R:W356	2.61	No	Yes	31	7	8
782	R:R:N389	R:R:W356	3.39	No	Yes	0	9	8
783	R:R:G357	R:R:P358	4.06	No	No	0	5	9
784	R:R:C386	R:R:L359	6.35	No	No	0	7	7
785	R:R:I362	R:R:I375	2.94	No	Yes	13	4	3
786	R:R:F379	R:R:I362	7.54	No	No	13	4	4
787	R:R:F379	R:R:M363	2.49	No	Yes	13	4	6
788	R:R:K370	R:R:Y365	5.97	No	No	0	1	4
789	R:R:D366	R:R:M371	6.93	No	No	0	4	1
790	R:R:F368	R:R:V367	3.93	No	No	0	5	4
791	R:R:I375	R:R:M371	8.75	Yes	No	0	3	1
792	R:R:K376	R:R:M371	10.08	No	No	0	2	1
793	R:R:L374	R:R:T377	4.42	No	No	0	4	1
794	R:R:L374	R:R:V378	2.98	No	No	0	4	4
795	R:R:F379	R:R:I375	2.51	No	Yes	13	4	3
796	R:R:L385	R:R:M384	4.24	No	No	0	7	5
797	R:R:L388	R:R:T391	4.42	No	Yes	0	5	7
798	R:R:I396	R:R:V392	3.07	No	No	0	9	6
799	R:R:N393	R:R:Y397	8.14	No	Yes	8	9	9
800	R:R:D403	R:R:S401	4.42	No	No	18	6	8
801	R:R:K402	R:R:R405	3.71	No	No	0	5	8
802	R:R:H406	R:R:K402	7.86	No	No	0	4	5
803	A:A:F189	A:A:K54	2.48	Yes	No	0	3	8
804	A:A:K317	A:A:R313	2.48	Yes	No	0	3	5
805	A:A:F274	A:A:L283	2.44	No	Yes	0	6	5
806	B:B:F292	B:B:N313	2.42	No	No	0	4	7
807	B:B:D312	B:B:F292	2.39	No	No	0	5	4
808	B:B:D212	B:B:R214	2.38	No	No	0	9	9
809	B:B:D312	R:R:R145	2.38	No	No	0	5	6
810	R:R:D176	R:R:R182	2.38	No	No	0	3	4
811	R:R:L147	R:R:Y153	2.34	No	Yes	0	9	9
812	A:A:E25	A:A:R21	2.33	No	No	0	4	4
813	A:A:E28	A:A:R32	2.33	No	No	0	4	4
814	A:A:E245	A:A:R242	2.33	No	Yes	0	4	9
815	G:G:E17	G:G:R13	2.33	No	No	0	6	6
816	R:R:H304	R:R:R307	2.26	Yes	No	0	7	4
817	A:A:G202	A:A:G203	2.11	No	No	0	9	9
818	B:B:G115	B:B:G116	2.11	No	No	0	9	9
819	A:A:C351	A:A:G352	1.96	Yes	No	0	4	4
820	B:B:A140	B:B:G141	1.95	No	No	0	5	5
821	B:B:A208	B:B:G202	1.95	No	No	0	6	6
822	B:B:A231	B:B:G244	1.95	No	No	0	5	5
823	B:B:A305	B:B:G306	1.95	No	No	0	4	4
824	B:B:A309	B:B:G310	1.95	No	No	0	3	5
825	R:R:A160	R:R:G157	1.95	No	No	0	9	6
826	R:R:A198	R:R:G195	1.95	No	No	0	5	4
827	R:R:C382	R:R:P358	1.88	No	No	0	5	9
828	B:B:A106	B:B:P107	1.87	No	No	0	6	6
829	B:B:A193	B:B:P194	1.87	No	No	0	4	4
830	R:R:G281	R:R:S284	1.86	No	No	0	3	5
831	B:B:G41	B:B:V40	1.84	No	No	0	1	3
832	B:B:G306	B:B:V296	1.84	No	Yes	0	4	5
833	B:B:G324	B:B:V320	1.84	No	No	0	9	7
834	B:B:G115	B:B:T102	1.82	No	No	0	9	8
835	B:B:G185	B:B:T164	1.82	No	No	0	5	6
836	B:B:G244	B:B:T243	1.82	No	Yes	0	5	8
837	R:R:A202	R:R:A244	1.79	No	No	0	7	8
838	R:R:A211	R:R:A293	1.79	No	No	0	8	7
839	R:R:A305	R:R:A335	1.79	No	No	33	5	4
840	B:B:G202	B:B:I229	1.76	No	No	0	6	7
841	R:R:G281	R:R:I280	1.76	No	Yes	0	3	5
842	G:G:P53	G:G:T52	1.75	No	No	0	8	4
843	B:B:G77	B:B:K78	1.74	No	No	0	8	8
844	A:A:G27	B:B:L55	1.71	No	No	0	5	6
845	A:A:A41	A:A:S246	1.71	No	No	0	7	9
846	B:B:A28	G:G:S31	1.71	No	No	0	4	9
847	R:R:G205	R:R:L286	1.71	No	No	0	5	8
848	B:B:A28	G:G:V30	1.7	No	No	0	4	8
849	B:B:A203	B:B:V187	1.7	No	Yes	0	8	9
850	B:B:G238	B:B:N239	1.7	No	No	0	7	2
851	B:B:A309	B:B:V307	1.7	No	No	0	3	3
852	R:R:A398	R:R:V137	1.7	No	No	0	7	9
853	A:A:I285	A:A:P282	1.69	No	No	0	4	7
854	R:R:A244	R:R:T201	1.68	No	No	0	8	6
855	R:R:D366	R:R:G369	1.68	No	No	0	4	3
856	A:A:G183	A:A:Q204	1.64	No	Yes	0	7	9
857	R:R:L222	R:R:P221	1.64	No	No	0	7	8
858	R:R:L385	R:R:P358	1.64	No	No	0	7	9
859	A:A:I19	B:B:A92	1.62	No	No	0	9	6
860	B:B:I18	G:G:A23	1.62	No	No	0	7	8
861	B:B:I33	G:G:A34	1.62	No	No	0	3	6
862	B:B:A92	B:B:I80	1.62	No	Yes	0	6	8
863	R:R:S123	R:R:V171	1.62	No	No	0	7	7
864	R:R:S185	R:R:V188	1.62	No	No	0	7	5
865	R:R:A198	R:R:I245	1.62	No	No	0	5	4
866	B:B:D38	B:B:P39	1.61	No	No	0	1	1
867	R:R:A301	R:R:M337	1.61	No	No	0	8	6
868	A:A:S47	A:A:T48	1.6	No	No	0	9	9
869	A:A:V335	A:A:V339	1.6	No	No	0	3	6
870	A:A:V339	A:A:V342	1.6	No	No	0	6	8
871	B:B:S207	B:B:T223	1.6	No	No	0	5	2
872	B:B:S275	B:B:T274	1.6	No	No	0	8	8
873	R:R:V351	R:R:V392	1.6	No	No	0	6	6
874	B:B:C103	B:B:L79	1.59	No	Yes	0	8	7
875	R:R:T125	R:R:V121	1.59	No	No	0	4	4
876	R:R:C382	R:R:L359	1.59	No	No	0	5	7
877	A:A:A299	A:A:L283	1.58	No	Yes	0	4	5
878	B:B:L4	G:G:A12	1.58	No	No	0	4	5
879	B:B:A240	B:B:L252	1.58	No	No	0	6	7
880	B:B:A240	G:G:L37	1.58	No	No	0	6	7
881	R:R:A160	R:R:L138	1.58	No	No	0	9	7
882	R:R:A407	R:R:L147	1.58	No	No	0	7	9
883	R:R:A342	R:R:L298	1.58	No	No	0	7	6
884	R:R:A398	R:R:L404	1.58	No	No	0	7	8
885	A:A:E289	A:A:P288	1.57	No	No	0	5	7
886	B:B:T164	B:B:T165	1.57	No	No	0	6	7
887	R:R:A160	R:R:N134	1.56	No	Yes	0	9	9
888	R:R:C257	R:R:D272	1.56	No	No	11	9	5
889	A:A:I278	A:A:S281	1.55	No	No	0	9	1
890	B:B:I123	B:B:S136	1.55	Yes	No	0	6	4
891	A:A:I49	A:A:V50	1.54	No	No	0	9	7
892	G:G:A45	G:G:D48	1.54	No	Yes	0	4	9
893	R:R:I169	R:R:V168	1.54	Yes	No	0	5	4
894	R:R:I227	R:R:V228	1.54	No	Yes	0	4	6
895	R:R:I243	R:R:V246	1.54	No	No	0	5	3
896	R:R:A305	R:R:D338	1.54	No	No	33	5	7
897	R:R:A335	R:R:D338	1.54	No	No	33	4	7
898	R:R:I354	R:R:V350	1.54	No	No	0	5	6
899	R:R:I362	R:R:V378	1.54	No	No	0	4	4
900	G:G:K20	G:G:V16	1.52	No	No	0	6	7
901	R:R:M277	R:R:V367	1.52	No	No	0	4	4
902	G:G:A39	G:G:E42	1.51	No	No	0	3	1
903	A:A:K317	A:A:T316	1.5	Yes	No	0	3	3
904	B:B:G53	B:B:R52	1.5	No	No	0	9	7
905	R:R:L147	R:R:S146	1.5	No	No	0	9	5
906	R:R:K232	R:R:T229	1.5	No	No	0	5	8
907	A:A:L5	A:A:V13	1.49	No	No	0	2	3
908	R:R:L122	R:R:V121	1.49	No	No	0	5	4
909	R:R:L387	R:R:V171	1.49	No	No	0	7	7
910	R:R:L253	R:R:V249	1.49	No	No	0	5	5
911	R:R:L347	R:R:V350	1.49	No	No	0	7	6
912	A:A:D9	A:A:S6	1.47	No	No	0	4	7
913	B:B:L152	B:B:T196	1.47	Yes	No	0	3	1
914	G:G:L51	G:G:T52	1.47	Yes	No	0	6	4
915	R:R:L239	R:R:T242	1.47	No	No	0	3	4
916	R:R:I353	R:R:I354	1.47	No	No	0	6	5
917	A:A:N269	A:A:T48	1.46	No	No	0	8	9
918	R:R:D184	R:R:V188	1.46	No	No	0	2	5
919	B:B:I18	B:B:K15	1.45	No	No	0	7	6
920	G:G:I28	G:G:K32	1.45	No	No	0	4	5
921	R:R:I169	R:R:K192	1.45	Yes	No	0	5	6
922	R:R:P231	R:R:R230	1.44	No	No	0	4	1
923	R:R:I243	R:R:L239	1.43	No	No	0	5	3
924	R:R:I395	R:R:L399	1.43	No	No	0	6	5
925	R:R:Q115	R:R:T377	1.42	No	No	0	2	1
926	R:R:I375	R:R:N372	1.42	Yes	No	0	3	1
927	B:B:L14	G:G:K20	1.41	Yes	No	0	8	6
928	R:R:G254	R:R:W255	1.41	No	No	0	5	5
929	A:A:M18	A:A:N22	1.4	No	No	0	4	4
930	B:B:K15	B:B:N16	1.4	No	No	0	6	1
931	A:A:P288	A:A:Y287	1.39	No	Yes	0	7	6
932	A:A:D26	B:B:K78	1.38	No	No	0	5	8
933	B:B:D20	B:B:K23	1.38	No	No	0	2	2
934	R:R:L132	R:R:L136	1.38	No	No	0	3	7
935	A:A:D309	A:A:L310	1.36	No	No	0	3	4
936	G:G:L19	G:G:Q18	1.33	No	No	0	9	9
937	A:A:R208	A:A:S252	1.32	Yes	No	0	9	5
938	R:R:F170	R:R:V171	1.31	No	No	0	7	7
939	B:B:H91	B:B:N132	1.28	No	No	0	5	3
940	B:B:H266	B:B:N268	1.28	No	No	0	4	4
941	B:B:E10	B:B:Q6	1.27	No	No	0	8	1
942	B:B:I18	B:B:R22	1.25	No	No	0	7	6
943	A:A:M18	A:A:R21	1.24	No	No	0	4	4
944	A:A:F354	A:A:K349	1.24	Yes	No	0	7	9
945	R:R:F368	R:R:K370	1.24	No	No	0	5	1
946	B:B:N16	B:B:R19	1.21	No	No	0	1	4
947	R:R:I375	R:R:Y365	1.21	Yes	No	0	3	4
948	R:R:K192	R:R:Y172	1.19	No	No	0	6	7
949	B:B:Q44	B:B:R42	1.17	No	No	0	4	2
950	R:R:H143	R:R:R145	1.13	No	No	0	5	6
951	A:A:R21	A:A:R24	1.07	No	No	0	4	3

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	A:A:V34	5.02	4	6	5
2	A:A:F189	5.0275	4	6	3
3	A:A:F191	8.545	4	6	3
4	A:A:F196	6.065	4	6	4
5	A:A:F199	5.446	5	1	7
6	A:A:Q204	4.794	5	1	9
7	A:A:R208	2.9225	4	1	9
8	A:A:K210	5.34	6	1	8
9	A:A:W211	5.2125	4	1	9
10	A:A:F215	4.06	6	1	7
11	A:A:I221	5.4125	4	1	8
12	A:A:F223	7.255	4	0	7
13	A:A:V225	3.455	4	4	7
14	A:A:Y230	5.10167	6	10	8
15	A:A:N241	5.815	4	0	6
16	A:A:R242	10.314	5	21	9
17	A:A:M243	4.554	5	0	9
18	A:A:F250	6.004	5	4	9
19	A:A:C254	3.5025	4	4	8
20	A:A:W258	6.85	6	5	4
21	A:A:F259	7.8725	4	1	5
22	A:A:I265	3.195	4	7	6
23	A:A:L266	4.53	5	4	8
24	A:A:F267	3.045	6	7	9
25	A:A:L268	5.24167	6	4	9
26	A:A:L283	3.852	5	10	5
27	A:A:Y287	6.39714	7	10	6
28	A:A:Y290	4.89	5	10	6
29	A:A:T295	3.8925	4	15	3
30	A:A:Q304	6.595	4	4	7
31	A:A:F307	3.7775	4	4	5
32	A:A:N311	3.6425	4	4	4
33	A:A:K317	2.584	5	4	3
34	A:A:I319	4.425	4	4	4
35	A:A:H322	5.88	5	7	5
36	A:A:F323	4.956	5	4	9
37	A:A:T324	3.982	5	7	4
38	A:A:D328	6.8125	4	7	8
39	A:A:N331	6.435	4	7	4
40	A:A:F334	6.14	5	7	5
41	A:A:F336	7.406	5	6	8
42	A:A:D341	7.855	4	7	6
43	A:A:C351	4.3975	4	8	4
44	A:A:L353	5.905	4	8	8
45	A:A:F354	4.738	5	0	7
46	B:B:L14	4.314	5	19	8
47	B:B:L30	4.0175	4	23	5
48	B:B:L51	9.835	4	2	9
49	B:B:H54	6.435	4	2	9
50	B:B:I58	3.7375	4	0	9
51	B:B:W63	6.07667	6	0	7
52	B:B:R68	9.73	4	2	5
53	B:B:L70	5.6925	4	0	5
54	B:B:L79	3.33	4	0	7
55	B:B:I80	6.188	5	2	8
56	B:B:W82	11.0233	6	2	9
57	B:B:S84	4.1825	4	2	5
58	B:B:Y85	9.655	4	2	4
59	B:B:K89	8.23	4	0	9
60	B:B:I93	4.6625	4	0	7
61	B:B:Y105	3.47143	7	0	6
62	B:B:Y111	6.995	4	0	4
63	B:B:V112	3.44	4	0	8
64	B:B:I123	3.13	5	0	6
65	B:B:Y124	5.098	5	0	6
66	B:B:H142	5.265	6	14	9
67	B:B:Y145	5.15875	8	1	8
68	B:B:F151	4.226	5	0	9
69	B:B:L152	4.44	4	25	3
70	B:B:T159	5.6825	4	14	9
71	B:B:C166	3.81	4	12	8
72	B:B:L168	3.5975	4	0	6
73	B:B:W169	8.24833	6	14	8
74	B:B:D170	5.4775	4	26	9
75	B:B:F180	7.03	4	0	7
76	B:B:D186	6.97	5	1	9
77	B:B:V187	3.3	4	12	9
78	B:B:M188	4.56	4	1	8
79	B:B:L190	5.9225	4	0	5
80	B:B:F199	6.142	5	12	9
81	B:B:S201	3.8725	4	12	9
82	B:B:C204	4.066	5	1	7
83	B:B:W211	9.27	5	12	8
84	B:B:Q220	6.755	4	3	7
85	B:B:D228	7.665	4	1	9
86	B:B:I232	4.705	4	3	8
87	B:B:F235	9.264	5	17	6
88	B:B:P236	7.4475	4	17	7
89	B:B:F241	6.005	6	3	6
90	B:B:T243	4.522	5	3	8
91	B:B:D246	7.46	4	1	9
92	B:B:T249	6.0925	4	3	6
93	B:B:R251	8.864	5	3	8
94	B:B:F253	6.65	4	3	6
95	B:B:D258	8.7825	4	3	7
96	B:B:M262	5.395	4	23	4
97	B:B:Y264	5.9125	4	0	5
98	B:B:C271	6.0525	4	5	5
99	B:B:F278	4.34333	6	17	7
100	B:B:R283	7.164	5	16	9
101	B:B:Y289	6.92667	6	5	7
102	B:B:D290	6.0925	4	5	6
103	B:B:C294	3.8975	4	9	5
104	B:B:N295	6.58	4	5	6
105	B:B:V296	4.185	4	0	5
106	B:B:W297	5.4375	4	5	8
107	B:B:H311	6.61167	6	9	9
108	B:B:R314	10.1225	4	5	8
109	B:B:L318	2.9725	4	9	6
110	B:B:T329	4.43	4	9	8
111	B:B:W332	11.0967	6	5	9
112	B:B:D333	4.5625	4	9	9
113	B:B:K337	5.93	4	9	6
114	B:B:I338	4.335	4	2	5
115	B:B:W339	6.4925	4	9	9
116	G:G:Y40	7.53	4	17	6
117	G:G:D48	7.0525	4	0	9
118	G:G:L51	5.935	4	0	6
119	G:G:F61	5.03143	7	2	8
120	R:R:Q116	7.7025	4	27	4
121	R:R:T130	4.7775	4	28	7
122	R:R:E133	5.104	5	28	8
123	R:R:N134	3.285	4	0	9
124	R:R:Y153	7.2725	4	18	9
125	R:R:L159	4.492	5	8	9
126	R:R:I169	3.8025	4	0	5
127	R:R:F208	6.9275	4	0	7
128	R:R:R214	6.12	5	8	9
129	R:R:Y224	7.43	4	22	7
130	R:R:V228	2.945	4	22	6
131	R:R:W241	5.065	4	30	9
132	R:R:H270	5.106	5	11	3
133	R:R:I271	5.75	4	11	3
134	R:R:W279	3.5725	4	13	6
135	R:R:I280	3.356	5	13	5
136	R:R:Y294	5.05667	6	8	9
137	R:R:H304	3.822	5	7	7
138	R:R:L345	5.39	4	0	8
139	R:R:W356	3.635	6	31	8
140	R:R:M363	3.295	4	13	6
141	R:R:I375	3.366	5	13	3
142	R:R:T391	5.57	4	28	7
143	R:R:Y397	4.38286	7	8	9
144	W:W:?1	10.165	6	0	0

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	B:B:D83	B:B:L69	50.4749	2.71	No	No	0	8	5
2	B:B:L69	B:B:Y105	94.7486	3.52	No	Yes	0	5	6
3	B:B:V112	B:B:Y105	15.6275	2.52	Yes	Yes	0	8	6
4	B:B:L336	B:B:W82	17.4089	3.42	No	Yes	2	7	9
5	B:B:I58	B:B:L336	40.0826	2.85	Yes	No	0	9	7
6	B:B:G330	B:B:I58	51.7994	3.53	No	Yes	0	5	9
7	B:B:G330	B:B:H311	51.7819	3.18	No	Yes	0	5	9
8	B:B:D333	B:B:H311	100	7.56	Yes	Yes	9	9	9
9	B:B:D333	B:B:N313	99.9877	2.69	Yes	No	0	9	7
10	B:B:N313	B:B:W332	99.6256	9.04	No	Yes	0	7	9
11	A:A:W258	B:B:W332	86.9201	3.75	Yes	Yes	5	4	9
12	A:A:K209	A:A:W258	89.9046	6.96	No	Yes	5	9	4
13	A:A:I212	A:A:K209	89.8518	2.91	No	No	0	9	9
14	A:A:F259	A:A:I212	89.7704	5.02	Yes	No	0	5	9
15	A:A:F259	A:A:I221	89.3878	10.05	Yes	Yes	1	5	8
16	A:A:I221	A:A:L39	84.8559	4.28	Yes	No	1	8	9
17	A:A:I253	A:A:L39	84.8007	8.56	No	No	1	7	9
18	A:A:I253	A:A:L249	84.4959	4.28	No	No	1	7	5
19	A:A:F223	A:A:L249	85.5541	7.31	Yes	No	0	7	5
20	A:A:F223	A:A:G40	75.0757	3.01	Yes	No	0	7	9
21	A:A:G40	A:A:K46	74.9842	3.49	No	No	0	9	9
22	A:A:D200	A:A:K46	74.8927	6.91	No	No	0	5	9
23	A:A:D200	A:A:L38	74.618	4.07	No	No	0	5	8
24	A:A:I222	A:A:L38	72.8566	2.85	No	No	0	8	8
25	A:A:F267	A:A:I222	70.192	2.51	Yes	No	0	9	8
26	A:A:F267	A:A:F334	71.1005	3.22	Yes	Yes	7	9	5
27	A:A:F334	R:R:T313	79.0193	2.59	Yes	No	7	5	3
28	R:R:M308	R:R:T313	78.9488	3.01	No	No	7	7	3
29	R:R:H304	R:R:M308	78.5707	3.94	Yes	No	7	7	7
30	R:R:H304	R:R:M337	78.5837	2.63	Yes	No	0	7	6
31	A:A:F354	R:R:M337	78.3564	2.49	Yes	No	0	7	6
32	A:A:F354	A:A:L348	41.0291	8.53	Yes	No	0	7	8
33	A:A:F307	A:A:M243	10.2833	3.73	Yes	Yes	0	5	9
34	A:A:F223	A:A:V225	10.1791	2.62	Yes	Yes	0	7	7
35	A:A:F323	A:A:L268	11.9343	4.87	Yes	Yes	4	9	9
36	A:A:F323	A:A:K271	12.3794	8.69	Yes	No	0	9	9
37	A:A:C325	A:A:K271	12.347	6.47	No	No	0	9	9
38	A:A:C325	A:A:D328	12.3147	9.34	No	Yes	0	9	8
39	B:B:R314	B:B:W332	12.2363	22.99	Yes	Yes	5	8	9
40	A:A:L348	A:A:L353	36.82	4.15	No	Yes	0	8	8
41	A:A:F354	R:R:L341	36.8726	6.09	Yes	No	0	7	8
42	A:A:L353	R:R:L341	36.7488	4.15	Yes	No	0	8	8
43	A:A:L353	R:R:R214	69.5526	12.15	Yes	Yes	8	8	9
44	B:B:H62	B:B:Y105	72.5236	3.27	No	Yes	0	6	6
45	B:B:H62	B:B:R150	71.9524	9.03	No	No	0	6	6
46	B:B:C148	B:B:R150	71.381	6.96	No	No	0	6	6
47	B:B:C148	B:B:L190	70.8096	3.17	No	Yes	0	6	5
48	B:B:F199	B:B:L190	28.7892	8.53	Yes	Yes	0	9	5
49	B:B:F199	B:B:W211	24.7715	10.02	Yes	Yes	12	9	8
50	B:B:K209	B:B:W211	21.9853	9.28	No	Yes	12	6	8
51	B:B:K209	B:B:T221	21.4093	9.01	No	No	0	6	7
52	B:B:T221	G:G:E22	20.8319	7.06	No	No	0	7	9
53	G:G:E22	G:G:Q18	20.2545	2.55	No	No	0	9	9
54	G:G:L19	G:G:Q18	15.0543	1.33	No	No	0	9	9
55	B:B:L14	G:G:L19	14.4761	5.54	Yes	No	0	8	9
56	B:B:D290	B:B:R314	15.1472	11.91	Yes	Yes	5	6	8
57	B:B:C271	B:B:D290	14.8944	6.22	Yes	Yes	5	5	6
58	B:B:C271	B:B:Y289	13.6938	5.38	Yes	Yes	5	5	7
59	B:B:D83	B:B:R68	45.1364	5.96	No	Yes	0	8	5
60	B:B:R68	B:B:S84	56.4486	2.64	Yes	Yes	2	5	5
61	B:B:S84	G:G:F61	34.1058	6.61	Yes	Yes	2	5	8
62	B:B:N340	G:G:F61	46.1248	4.83	No	Yes	2	9	8
63	B:B:M45	B:B:N340	46.3028	2.8	No	No	0	4	9
64	B:B:L308	B:B:M45	46.3872	2.83	No	No	0	7	4
65	B:B:R68	B:B:Y85	34.0527	26.75	Yes	Yes	2	5	4
66	B:B:Y85	G:G:F61	34.5053	5.16	Yes	Yes	2	4	8
67	B:B:H311	B:B:K337	23.7151	3.93	Yes	Yes	9	9	6
68	B:B:H311	B:B:T329	24.7875	4.11	Yes	Yes	9	9	8
69	B:B:T329	B:B:W339	23.6893	7.28	Yes	Yes	9	8	9
70	B:B:K337	B:B:W339	23.6442	9.28	Yes	Yes	9	6	9
71	B:B:L308	B:B:W339	47.313	4.56	No	Yes	0	7	9
72	B:B:I338	B:B:L51	22.6777	5.71	Yes	Yes	2	5	9
73	B:B:L70	B:B:W82	11.5416	4.56	Yes	Yes	0	5	9
74	B:B:L70	B:B:M61	11.439	2.83	Yes	No	0	5	6
75	B:B:C317	B:B:M61	11.4587	4.86	No	No	0	7	6
76	B:B:C317	B:B:I58	11.483	3.27	No	Yes	0	7	9
77	B:B:L70	B:B:W63	22.9061	12.53	Yes	Yes	0	5	7
78	B:B:S84	B:B:W63	22.5256	4.94	Yes	Yes	0	5	7
79	B:B:D66	B:B:R68	45.1075	3.57	No	Yes	0	8	5
80	B:B:D66	B:B:L69	44.843	2.71	No	No	0	8	5
81	B:B:L190	B:B:V158	33.3986	2.98	Yes	No	0	5	5
82	B:B:L168	B:B:V158	32.8229	4.47	Yes	No	0	6	5
83	B:B:L168	B:B:T177	29.3816	2.95	Yes	No	0	6	4
84	B:B:D170	B:B:T177	28.3308	4.34	Yes	No	0	9	4
85	B:B:D170	B:B:N155	26.0228	6.73	Yes	No	26	9	3
86	B:B:I171	B:B:N155	25.4475	2.83	No	No	0	6	3
87	B:B:I157	B:B:I171	13.3091	2.94	No	No	0	7	6
88	B:B:I123	B:B:I171	11.5739	2.94	Yes	No	0	6	6
89	R:R:R214	R:R:Y294	41.3356	7.2	Yes	Yes	8	9	9
90	R:R:A211	R:R:Y294	37.2797	4	No	Yes	0	8	9
91	R:R:A211	R:R:I290	36.7407	3.25	No	No	0	8	8
92	R:R:F208	R:R:I290	12.0661	3.77	Yes	No	0	7	8
93	R:R:F208	R:R:L286	10.9924	8.53	Yes	No	0	7	8
94	R:R:L286	R:R:V204	10.4553	4.47	No	No	0	8	7
95	R:R:T283	R:R:V204	10.1753	3.17	No	No	0	8	7
96	R:R:F379	R:R:M363	18.174	2.49	No	Yes	13	4	6
97	R:R:F379	R:R:I375	14.8705	2.51	No	Yes	13	4	3
98	R:R:I375	R:R:M371	11.0235	8.75	Yes	No	0	3	1
99	R:R:I290	R:R:L352	24.4057	2.85	No	No	0	8	9
100	R:R:L287	R:R:L352	24.1346	5.54	No	No	0	6	9
101	R:R:L287	R:R:W356	23.8635	4.56	No	Yes	0	6	8
102	R:R:L360	R:R:W356	20.6139	4.56	No	Yes	0	7	8
103	R:R:I280	R:R:L360	20.3415	4.28	Yes	No	0	5	7
104	R:R:R214	R:R:Y397	28.0941	3.09	Yes	Yes	8	9	9
105	R:R:L207	R:R:Y397	12.9517	3.52	No	Yes	8	8	9
106	R:R:L159	R:R:L207	12.6778	5.54	Yes	No	8	9	8
107	R:R:D163	R:R:L159	19.8561	5.43	No	Yes	0	9	9
108	R:R:D163	R:R:P394	18.7553	4.83	No	No	0	9	9
109	R:R:N134	R:R:P394	18.2048	4.89	Yes	No	0	9	9
110	R:R:N393	R:R:Y397	12.9518	8.14	No	Yes	8	9	9
111	R:R:L159	R:R:N393	12.6778	5.49	Yes	No	8	9	9
112	R:R:I280	R:R:L276	10.191	2.85	Yes	No	13	5	5
113	B:B:L336	B:B:L51	22.68	4.15	No	Yes	2	7	9
114	B:B:I338	G:G:F61	22.6164	3.77	Yes	Yes	2	5	8

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:I169	R:R:L165	4.28	0	Yes	No	5	6	1	2
R:R:I169	W:W:?1	7.94	0	Yes	Yes	5	0	1	0
R:R:F191	W:W:?1	31.63	0	No	Yes	5	0	1	0
R:R:G194	W:W:?1	4.76	0	No	Yes	6	0	1	0
R:R:G195	W:W:?1	9.52	0	No	Yes	4	0	1	0
R:R:A248	W:W:?1	4.38	0	No	Yes	7	0	1	0
R:R:L252	R:R:V249	2.98	11	No	No	5	5	2	1
R:R:V249	W:W:?1	2.76	0	No	Yes	5	0	1	0
R:R:A198	R:R:G195	1.95	0	No	No	5	4	2	1
R:R:I169	R:R:V168	1.54	0	Yes	No	5	4	1	2
R:R:L253	R:R:V249	1.49	0	No	No	5	5	2	1
R:R:I169	R:R:K192	1.45	0	Yes	No	5	6	1	2

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

Similarity	Network Type	Name	Ligand	Description
66.67	Single	7WV9	ZCZ011	7WV9-CB₁-CP55940-ZCZ011-Gi2/β1/γ2
55.56	Single	8IKH	Q2L	8IKH-CB₁-Q2L-Gi1/β1/γ1
40.00	Single	7FEE	ZCZ011	7FEE-CB₁-CP55940-ZCZ011
25.00	Single	8T3V	Docosa-4,7,10,13,16,19-Hexaenoic acid	8T3V-FFA1-Docosa-4,7,10,13,16,19-Hexaenoic acid-chim(NtGi2L-Gs-CtGq)/β1/γ2
21.43	Single	8EJK	TAK-875	8EJK-FFA1-TAK-875-chim(NtGi1L-Gs-CtGq)/β1/γ2
20.00	Single	4PHU	Fasiglifam	4PHU-FFA1-Fasiglifam
18.75	Single	5TZR	MK8666	5TZR-FFA1-MK8666
17.65	Single	5TZY	MK8666; PubChem 127053597	5TZY-FFA1-MK8666; PubChem 127053597
12.50	Single	8EJC	TAK-875	8EJC-FFA1-TAK-875-chim(NtGi1L-Gs-CtGq)/β1/γ2
9.09	Single	7Y14	Beta-Alanine	7Y14-MRGPRD-β-Alanine
8.33	Single	7Y12	Beta-Alanine	7Y12-MRGPRD-β-Alanine-Gi1/β1/γ2
7.69	Single	5NDZ	AZ3451; Na	5NDZ-PAR2-AZ3451; Na
7.69	Single	8YN2	Histamine	8YN2-H₁-Histamine-chim(NtGi1L-Gs-CtGq)/β1/γ2
7.14	Single	4XNV	BPTU	4XNV-P2Y₁-BPTU
7.14	Single	6ME2	Ramelteon	6ME2-MT₁-Ramelteon
7.14	Single	7T8X	Acetylcholine	7T8X-M₂-Acetylcholine-chim(NtGi1-Go)/β1/γ2
7.14	Single	7T90	Acetylcholine	7T90-M₂-Acetylcholine-chim(NtGi1-Go)/β1/γ2
7.14	Single	7T96	Acetylcholine	7T96-M₂-Acetylcholine-LY2119620-Go/β1/γ2
7.14	Single	8J20	Valeric acid	8J20-FFA3-Valeric acid-AR420626-Gi1/β1/γ2
7.14	Single	8T3S	Butyric acid	8T3S-FFA2-Butyric acid-chim(NtGi2L-Gs-CtGq)/β1/γ2
7.14	Consensus	m2_on	Orthosteric Ligand	7T8X-M₂-Acetylcholine-chim(NtGi1-Go)/β1/γ2
7.14	Consensus	m2_on_gp	Orthosteric Ligand	7T8X-M₂-Acetylcholine-chim(NtGi1-Go)/β1/γ2
6.67	Single	3RZE	Cidoxepin	3RZE-H₁-Cidoxepin
6.67	Single	4MQT	Iperoxo	4MQT-M₂-Iperoxo-LY2119620
6.67	Single	6ME4	2-Iodomelatonin	6ME4-MT₁-2-Iodomelatonin
6.67	Single	6PS8	2-Phenylmelatonin	6PS8-MT₁-2-Phenylmelatonin
6.67	Single	6TPK	Retosiban	6TPK-OT-Retosiban
6.67	Single	6VI4	JDTic	6VI4-κ-JDTic
6.67	Single	7T94	Acetylcholine	7T94-M₂-Acetylcholine-PubChem 57664406-chim(NtGi1-Go)/β1/γ2
6.67	Single	7TRS	Acetylcholine	7TRS-M₄-Acetylcholine-Gi1/β1/γ2
6.67	Single	8HQN	9-S-HODE	8HQN-GPR132-9-S-HODE-Gi1/β1/γ2
6.67	Single	8IYX	YL-365	8IYX-GPR34-YL-365
6.67	Single	8K4N	VF0	8K4N-GPR34-VF0-Gi1/β1/γ2
6.67	Single	8Y53	MK5046	8Y53-BB₃-MK5046-chim(NtGi1-Gs-CtGq)/β1/γ2
6.67	Single	8YN8	Proxyfan	8YN8-H₃-Proxyfan-Go1/β1/γ2
6.67	Single	9K1D	Butanoic acid	9K1D-FFA2-Butanoic acid-Cholesterol-Gi1/β1/γ2
6.67	Consensus	ot_off	Orthosteric Ligand	6TPK-OT-Retosiban
6.67	Consensus	vasop-oxy_off	Orthosteric Ligand	ot_off
6.25	Single	4DAJ	Tiotropium	4DAJ-M₃-Tiotropium
6.25	Single	4MQS	Iperoxo	4MQS-M₂-Iperoxo
6.25	Single	4U14	Tiotropium	4U14-M₃-Tiotropium
6.25	Single	5DSG	Tiotropium	5DSG-M₄-Tiotropium
6.25	Single	5YC8	N-Methyl-Scopolamine	5YC8-M₂-N-Methyl-Scopolamine
6.25	Single	5ZK8	N-Methyl-Scopolamine	5ZK8-M₂-N-Methyl-Scopolamine
6.25	Single	5ZKC	N-Methyl-Scopolamine	5ZKC-M₂-N-Methyl-Scopolamine
6.25	Single	7PP1	Selatogrel	7PP1-P2Y₁₂-Selatogrel
6.25	Single	7TRP	Iperoxo	7TRP-M₄-Iperoxo-LY2033298-Gi1/β1/γ2
6.25	Single	7VH0	Ramelteon	7VH0-MT₂-Ramelteon-Gi1/β1/γ1
6.25	Single	8DZS	GR89,696	8DZS-κ-GR89,696-chim(NtGi2-Gz)/β1/γ2
6.25	Single	8X63	Mepyramine	8X63-H₁-Mepyramine
6.25	Consensus	gi_histamine	Orthosteric Ligand	8JXX-H₄-Clobenpropit-Gi1/β1/γ2 8JXV-H₄-Clozapine-Gi1/β1/γ2 8YUU-H₃-Histamine-Gi1/β1/γ1 8HN8-H₄-Histamine-Gi1/β1/γ2 8HOC-H₄-Imetit-Gi1/β1/γ2 8JXW-H₄-VUF6884-Gi1/β1/γ2
6.25	Consensus	gq_amine	Orthosteric Ligand	gq_muscarinic gq_histamine
6.25	Consensus	histamine_off	Orthosteric Ligand	h1_off
6.25	Consensus	m4_off	Orthosteric Ligand	5DSG-M₄-Tiotropium
6.25	Consensus	muscarinic_on	Orthosteric Ligand	m2_on m3_on m4_on m1_on
6.25	Consensus	muscarinic_on_gp	Orthosteric Ligand	m2_on_gp m3_on_gp m4_on_gp m1_on_gp
5.88	Single	4NTJ	AZD1283	4NTJ-P2Y₁₂-AZD1283
5.88	Single	5XPR	Bosentan	5XPR-ET_B-Bosentan
5.88	Single	5ZK3	3-quinuclidinyl-benzilate	5ZK3-M₂-3-quinuclidinyl-benzilate
5.88	Single	6ME7	2-Phenylmelatonin	6ME7-MT₂-2-Phenylmelatonin
5.88	Single	6OIK	Iperoxo	6OIK-M₂-Iperoxo-LY2119620-chim(NtGi1-Go)/β1/γ2
5.88	Single	7TRK	Iperoxo	7TRK-M₄-Iperoxo-Gi1/β1/γ2
5.88	Single	8IZ4	Lysophosphatidylserine	8IZ4-GPR34-Lysophosphatidylserine-Gi1/β1/γ2
5.88	Single	8J18	(3R)-3-Hydroxydodecanoic acid	8J18-GPR84-(3R)-3-Hydroxydodecanoic acid-Gi1/β1/γ2
5.88	Single	9DQH	EP-2825	9DQH-MRGPRD-EP-2825-chim(NtGi1-Gs-CtGq)/β1/γ2
5.88	Consensus	cyslt_off	Orthosteric Ligand	cyslt2_off cyslt1_off
5.88	Consensus	gq_muscarinic	Orthosteric Ligand	6OIJ-M₁-Iperoxo-chim(NtGi1L-G11)/β1/γ2
5.88	Consensus	h1_off	Orthosteric Ligand	8X63-H₁-Mepyramine 3RZE-H₁-Cidoxepin 8X5Y-H₁-Astemizole
5.88	Consensus	m1_on	Orthosteric Ligand	6OIJ-M₁-Iperoxo-chim(NtGi1L-G11)/β1/γ2
5.88	Consensus	m2_off	Orthosteric Ligand	5ZKC-M₂-N-Methyl-Scopolamine 5ZK3-M₂-3-quinuclidinyl-benzilate 5ZKB-M₂-AF-DX 384
5.88	Consensus	m3_on	Orthosteric Ligand	8E9Z-M₃-Iperoxo-chim(NtGi2L-Gs-CtGq)/β1/γ2 8E9W-M₃-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/β1/γ2 8E9Y-M₃-Clozapine-N-oxide-chim(NtGi2L-Gs-CtGq)/β1/γ2
5.88	Consensus	m3_on_gp	Orthosteric Ligand	8E9Z-M₃-Iperoxo-chim(NtGi2L-Gs-CtGq)/β1/γ2 8E9W-M₃-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/β1/γ2 8E9Y-M₃-Clozapine-N-oxide-chim(NtGi2L-Gs-CtGq)/β1/γ2
5.56	Single	3UON	3-quinuclidinyl-benzilate	3UON-M₂-3-quinuclidinyl-benzilate
5.56	Single	4DJH	JDTic	4DJH-κ-JDTic
5.56	Single	4U15	Tiotropium	4U15-M₃-Tiotropium
5.56	Single	5ZHP	PubChem 134828589	5ZHP-M₃-PubChem 134828589
5.56	Single	6OIJ	Iperoxo	6OIJ-M₁-Iperoxo-chim(NtGi1L-G11)/β1/γ2
5.56	Single	6OL9	Tiotropium	6OL9-M₅-Tiotropium
5.56	Single	6RZ5	Zafirlukast	6RZ5-CysLT₁-Zafirlukast-Na
5.56	Single	7R0C	AVP	7R0C-V₂-AVP-Arrestin2
5.56	Single	7TRQ	Iperoxo	7TRQ-M₄-Iperoxo-VU0467154-Gi1/β1/γ2
5.56	Single	8EA0	Iperoxo	8EA0-M₃-Iperoxo
5.56	Single	8IYH	MK6892	8IYH-HCA₂-MK6892-Go/β1/γ2
5.56	Single	8JGF	BAM8-22	8JGF-MRGPRX1-BAM8-22-chim(NtGi1-Gs-CtGq)/β1/γ2
5.56	Single	8JXV	Clozapine	8JXV-H₄-Clozapine-Gi1/β1/γ2
5.56	Single	8JXW	VUF6884	8JXW-H₄-VUF6884-Gi1/β1/γ2
5.56	Single	8XBI	S3E-LysoPS	8XBI-GPR34-S3E-LysoPS
5.56	Single	9ITE	LPA	9ITE-LPA₆-LPA-chim(NtGi2-G13)/β1/γ2
5.56	Consensus	ffa2_on	Orthosteric Ligand	8J22-FFA2-TUG-1375-Gi1/β1/γ2
5.56	Consensus	h4_on_gp	Orthosteric Ligand	8HN8-H₄-Histamine-Gi1/β1/γ2 8HOC-H₄-Imetit-Gi1/β1/γ2 8JXV-H₄-Clozapine-Gi1/β1/γ2 8JXW-H₄-VUF6884-Gi1/β1/γ2 8JXX-H₄-Clobenpropit-Gi1/β1/γ2
5.56	Consensus	kop_off	Orthosteric Ligand	4DJH-κ-JDTic
5.56	Consensus	m1_on_gp	Orthosteric Ligand	6OIJ-M₁-Iperoxo-chim(NtGi1L-G11)/β1/γ2
5.56	Consensus	m3_off	Orthosteric Ligand	4U15-M₃-Tiotropium 4U16-M₃-N-Methyl-Scopolamine 5ZHP-M₃-PubChem 134828589
5.56	Consensus	m5_off	Orthosteric Ligand	6OL9-M₅-Tiotropium
5.56	Consensus	muscarinic_off	Orthosteric Ligand	m2_off m3_off m4_off m5_off m1_off
5.56	Consensus	p2y12_on	Orthosteric Ligand	7XXI-P2Y₁₂-2MeSADP-Gi2/β1/γ2
5.26	Single	4PXZ	2MeSADP	4PXZ-P2Y₁₂-2MeSADP
5.26	Single	4PY0	2MeSATP	4PY0-P2Y₁₂-2MeSATP
5.26	Single	5CXV	Tiotropium	5CXV-M₁-Tiotropium
5.26	Single	6ZG4	HTL0009936	6ZG4-M₁-HTL0009936
5.26	Single	7L1V	PubChem 155491009	7L1V-OX₂-PubChem 155491009-chim(NtGi1-Gs-CtGq)/β1/γ2
5.26	Single	7XW9	TRH	7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/β1/γ2
5.26	Single	7XXI	2MeSADP	7XXI-P2Y₁₂-2MeSADP-Gi2/β1/γ2
5.26	Single	8DWC	Proenkephalin-A	8DWC-MRGPRX1-Proenkephalin-A-chim(NtGi2L-Gs-CtGq)/β1/γ2
5.26	Single	8E9W	2-Deoxycytidine	8E9W-M₃-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/β1/γ2
5.26	Single	8G05	6-OAU	8G05-GPR84-6-OAU-Gi1/β1/γ2
5.26	Single	8H0Q	Gastrin Releasing Peptide	8H0Q-BB₂-Gastrin Releasing Peptide-chim(NtGi1-Gs-CtGq)/β1/γ2
5.26	Single	8JZ7	MK6892	8JZ7-HCA₂-MK6892-Gi1/β1/γ2
5.26	Single	8WRB	Lysophosphatidylserine	8WRB-GPR34-Lysophosphatidylserine-Gi1/β1/γ2
5.26	Consensus	ffa2_on_gp	Orthosteric Ligand	8J22-FFA2-TUG-1375-Gi1/β1/γ2
5.26	Consensus	gi_amine	Orthosteric Ligand	gi_5ht gi_muscarinic gi_adrenergic gi_dopamine gi_histamine
5.26	Consensus	gi_muscarinic	Orthosteric Ligand	8E9X-M₄-2-Deoxycytidine-chim(NtGi1-Go)/β1/γ2 7T8X-M₂-Acetylcholine-chim(NtGi1-Go)/β1/γ2 7TRS-M₄-Acetylcholine-Gi1/β1/γ2 7TRK-M₄-Iperoxo-Gi1/β1/γ2 7V6A-M₄-PubChem 9864275-Gi1/β1/γ2
5.26	Consensus	gi_p2y	Orthosteric Ligand	7XXI-P2Y₁₂-2MeSADP-Gi2/β1/γ2
5.26	Consensus	m1_off	Orthosteric Ligand	5CXV-M₁-Tiotropium
5.26	Consensus	m4_on	Orthosteric Ligand	7TRS-M₄-Acetylcholine-Gi1/β1/γ2 7V6A-M₄-PubChem 9864275-Gi1/β1/γ2 8E9X-M₄-2-Deoxycytidine-chim(NtGi1-Go)/β1/γ2 7TRK-M₄-Iperoxo-Gi1/β1/γ2
5.26	Consensus	m4_on_gp	Orthosteric Ligand	7TRS-M₄-Acetylcholine-Gi1/β1/γ2 7V6A-M₄-PubChem 9864275-Gi1/β1/γ2 8E9X-M₄-2-Deoxycytidine-chim(NtGi1-Go)/β1/γ2 7TRK-M₄-Iperoxo-Gi1/β1/γ2
5.26	Consensus	p2y12_on_gp	Orthosteric Ligand	7XXI-P2Y₁₂-2MeSADP-Gi2/β1/γ2
5.26	Consensus	trh_on	Orthosteric Ligand	7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/β1/γ2
5.26	Consensus	trh_on_gp	Orthosteric Ligand	7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/β1/γ2
5.00	Single	6RZ9	ONO-2770372	6RZ9-CysLT₂-ONO-2770372
5.00	Single	7D7M	Dinoprostone	7D7M-EP₄-Dinoprostone-Gs/β1/γ1
5.00	Single	7QVM	Oxytocin	7QVM-OT-Oxytocin-chim(NtGi1-Go-CtGq)/β1/γ2
5.00	Single	7VGY	2-Iodomelatonin	7VGY-MT₁-2-Iodomelatonin-Gi1/β1/γ2
5.00	Single	7X1U	TRH	7X1U-TRH-TRH-chim(NtGi2L-Gs-CtGq)/β1/γ2
5.00	Single	8E9X	2-Deoxycytidine	8E9X-M₄-2-Deoxycytidine-chim(NtGi1-Go)/β1/γ2
5.00	Single	8E9Y	Clozapine-N-oxide	8E9Y-M₃-Clozapine-N-oxide-chim(NtGi2L-Gs-CtGq)/β1/γ2
5.00	Single	8FX5	Xanomeline	8FX5-M₄-Xanomeline-Xanomeline-Gi1/β1/γ2
5.00	Single	8IJD	MK6892	8IJD-HCA₂-MK6892-Gi1/β1/γ2
5.00	Single	8J19	LY237	8J19-GPR84-LY237-Gi1/β1/γ2
5.00	Single	8XIO	L797591	8XIO-SST1-L797591-chim(NtGi1-Gs-CtGi1)/β1/γ2
5.00	Consensus	cyslt2_off	Orthosteric Ligand	6RZ7-CysLT₂-ONO-2570366 6RZ8-CysLT₂-ONO-2080365 6RZ9-CysLT₂-ONO-2770372
4.76	Single	6RZ6	ONO-2570366	6RZ6-CysLT₂-ONO-2570366
4.76	Single	8J22	TUG-1375	8J22-FFA2-TUG-1375-Gi1/β1/γ2
4.76	Single	8SAI	1-Oleoyl-2-Hydroxy-Sn-Glycero-3-Phospho-L-Serine	8SAI-GPR34-1-Oleoyl-2-Hydroxy-Sn-Glycero-3-Phospho-L-Serine-Gi1/β1/γ2
4.76	Single	9ITB	LPA	9ITB-LPA₆-LPA-chim(NtGi1-Gs-CtGq)/β1/γ2
4.55	Single	6RZ8	ONO-2080365	6RZ8-CysLT₂-ONO-2080365
4.55	Single	7WKD	TRH	7WKD-TRH-TRH-chim(NtGi1-Gs-CtGq)/β1/γ2
4.55	Single	8DWG	Proenkephalin-A	8DWG-MRGPRX1-Proenkephalin-A-ML382-chim(NtGi2L-Gs-CtGq)/β1/γ2
4.55	Single	8XBH	S3E-LysoPS	8XBH-GPR34-S3E-LysoPS-Gi1/β1/γ2
4.55	Consensus	gi_nucleotide	Orthosteric Ligand	gi_adenosine gi_p2y
4.35	Single	8F7W	Dynorphin	8F7W-κ-Dynorphin-Gi1/β1/γ2
4.17	Single	7RYC	Oxytocin	7RYC-OT-Oxytocin-chim(NtGi2L-Gs-CtGq)/β1/γ2
4.17	Single	7XOU	Cholecystokinin-8	7XOU-CCK_A-Cholecystokinin-8-Gs/β1/γ2
4.17	Single	8XGU	TAK448	8XGU-Kiss1-TAK448-Gi1/β1/γ2
4.17	Single	9K27	PrRP31	9K27-PrRP-PrRP31-chim(NtGi1-Gq)/β1/γ2
4.00	Single	7AD3	Alpha-factor mating pheromone	7AD3-STE2-α-factor mating pheromone-Gi1/STE4/γ2
4.00	Single	7DW9	AVP	7DW9-V₂-AVP-chim(NtGi1-Gs)/β1/γ2
4.00	Single	7KH0	AVP	7KH0-V₂-AVP-chim(NtGi1-Gs)/β1/γ2
4.00	Single	7W40	Bombesin	7W40-BB₂-Bombesin-chim(NtGi1L-Gq)/β1/γ2
4.00	Single	7YON	Peptide-YY(3-36)	7YON-Y₂-Peptide-YY(3-36)-Gi1/β1/γ2
4.00	Single	8IHF	MK6892	8IHF-HCA₂-MK6892-Gi1/β1/γ2
4.00	Single	8J6I	MK6892	8J6I-HCA₂-MK6892-Gi1/β1/γ2
4.00	Consensus	gs_vasop-oxy	Orthosteric Ligand	7DW9-V₂-AVP-chim(NtGi1-Gs)/β1/γ2
4.00	Consensus	p2y_on_gp	Orthosteric Ligand	p2y1_on_gp p2y10_on_gp p2y12_on_gp
4.00	Consensus	v2_on	Orthosteric Ligand	7DW9-V₂-AVP-chim(NtGi1-Gs)/β1/γ2
4.00	Consensus	v2_on_gp	Orthosteric Ligand	7DW9-V₂-AVP-chim(NtGi1-Gs)/β1/γ2
4.00	Consensus	vasop-oxy_on	Orthosteric Ligand	v2_on
4.00	Consensus	vasop-oxy_on_gp	Orthosteric Ligand	v2_on_gp
3.85	Single	8XGO	TAK448	8XGO-Kiss1-TAK448-chim(NtGi1-Gq)/β1/γ2
3.85	Single	8ZPS	PrRP20	8ZPS-PrRP-PrRP20-chim(NtGi1-Gs-CtGq)/β1/γ2
3.70	Single	7W3Z	Gastrin Releasing Peptide	7W3Z-BB₂-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/β1/γ2
3.70	Single	8H0P	NMB30	8H0P-BB₁-NMB30-chim(NtGi1-Gs-CtGq)/β1/γ2
3.57	Single	7AD3	Alpha-factor mating pheromone	7AD3-STE2-α-factor mating pheromone-Gi1/STE4/γ2
3.57	Single	7QBC	Alpha-factor mating pheromone	7QBC-STE2-α-factor mating pheromone
3.57	Single	7YOO	Neuropeptide-Y	7YOO-Y₂-Neuropeptide-Y-Gi1/β1/γ2
3.57	Single	9K26	PrRP31	9K26-PrRP-PrRP31-Gi1/β1/γ2
3.57	Consensus	npy2_on	Orthosteric Ligand	7YOO-Y₂-Neuropeptide-Y-Gi1/β1/γ2
3.57	Consensus	npy2_on_gp	Orthosteric Ligand	7YOO-Y₂-Neuropeptide-Y-Gi1/β1/γ2
3.45	Single	7QBC	Alpha-factor mating pheromone	7QBC-STE2-α-factor mating pheromone
3.45	Single	7VGX	Neuropeptide-Y	7VGX-Y₁-Neuropeptide-Y-Gi1/β1/γ2
3.33	Single	8ZJE	TAK-448	8ZJE-Kiss1-TAK-448-chim(NtGi1-Gq)/β1/γ1
3.33	Consensus	bb2_on	Orthosteric Ligand	7W40-BB₂-Bombesin-chim(NtGi1L-Gq)/β1/γ2 7W3Z-BB₂-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/β1/γ2
3.33	Consensus	bb2_on_gp	Orthosteric Ligand	7W40-BB₂-Bombesin-chim(NtGi1L-Gq)/β1/γ2 7W3Z-BB₂-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/β1/γ2
3.33	Consensus	bombesin_on	Orthosteric Ligand	bb2_on
3.33	Consensus	bombesin_on_gp	Orthosteric Ligand	bb2_on_gp
3.33	Consensus	gq_bombesin	Orthosteric Ligand	7W40-BB₂-Bombesin-chim(NtGi1L-Gq)/β1/γ2 7W3Z-BB₂-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/β1/γ2
3.12	Consensus	gs_peptide	Orthosteric Ligand	gs_cck gs_melanocortin gs_vasop-oxy
2.86	Consensus	mc2_on	Orthosteric Ligand	8GY7-MC₂-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1
2.86	Consensus	mc2_on_gp	Orthosteric Ligand	8GY7-MC₂-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1
2.44	Single	8GY7	Corticotropin	8GY7-MC₂-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1

PDB Summary
PDB	8IKG
Class	A
SubFamily	Lipid
Type	Cannabinoid
SubType	CB1
Species	Homo Sapiens
Ligand	-
Other Ligand(s)	Q2B
Protein Partners	Gi1/Beta1/Gamma1
PDB Resolution	3.4
Date	2024-06-05
D.O.I.	10.1073/pnas.2321532121

Net Summary
I_min	2.49
Number of Linked Nodes	799
Number of Links	951
Number of Hubs	144
Number of Links mediated by Hubs	520
Number of Communities	33
Number of Nodes involved in Communities	229
Number of Links involved in Communities	317

Path Summary
Number Of Nodes in MetaPath	115
Number Of Links MetaPath	114
Number of Shortest Paths	3580412
Length Of Smallest Path	3
Average Path Length	45.1694
Length of Longest Path	83
Minimum Path Strength	1.155
Average Path Strength	5.19955
Maximum Path Strength	20.78
Minimum Path Correlation	0.7
Average Path Correlation	0.991987
Maximum Path Correlation	1
Minimum % Of Corr. Nodes	2.22222
Average % Of Corr. Nodes	33.8712
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	46.8169
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function	• protein binding • binding • enzyme binding • GTPase binding • protein-containing complex binding • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • multicellular organismal process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development
Gene Ontology	Biological Process	• multicellular organismal process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development • anatomical structure development • sensory system development • system development • cell population proliferation • cellular process • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • signal transduction • cell communication • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • response to oxygen-containing compound • cellular response to oxygen-containing compound • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to chemical stimulus • cellular response to alcohol • response to hormone • response to chemical • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • small GTPase-mediated signal transduction • Ras protein signal transduction • intracellular signal transduction • intracellular signaling cassette • phospholipase C-activating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular response to nitrogen compound • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • response to nitrogen compound • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to monoamine stimulus • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • synaptic signaling • cellular response to acetylcholine • cell-cell signaling • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • cellular anatomical structure • membrane • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cell periphery • cytoplasmic side of plasma membrane • GTPase complex
Gene Ontology	Cellular Component	• cellular anatomical structure • membrane • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cell periphery • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • membrane-bounded organelle • extracellular vesicle • extracellular organelle • extracellular region • organelle • extracellular space • vesicle • extracellular membrane-bounded organelle • non-motile cilium • 9+0 non-motile cilium • cilium • neuron projection • photoreceptor disc membrane • photoreceptor outer segment • plasma membrane bounded cell projection • cell projection • photoreceptor cell cilium • organelle membrane • intracellular anatomical structure • cytoplasm • cytosol • vacuolar membrane • lytic vacuole • vacuole • intracellular membrane-bounded organelle • intracellular organelle • lytic vacuole membrane • bounding membrane of organelle • lysosomal membrane • lysosome • synapse • cell junction • D2 dopamine receptor binding • protein binding • binding • signaling receptor binding • G protein-coupled receptor binding • dopamine receptor binding • phosphorus-oxygen lyase activity • enzyme regulator activity • cyclase regulator activity • molecular function regulator activity • cyclase activity • adenylate cyclase regulator activity • lyase activity • catalytic activity • adenylate cyclase activity • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • cation binding • magnesium ion binding • metal ion binding • GDP binding • G protein-coupled serotonin receptor binding • protein-containing complex binding • G-protein beta/gamma-subunit complex binding • pyrophosphatase activity • GTPase activity • G protein activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • adenylate cyclase-inhibiting serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • cell communication • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular process • signal transduction • response to hormone • response to chemical • response to endogenous stimulus • response to peptide hormone • response to oxygen-containing compound • response to nitrogen compound • cell division • leukocyte migration • immune system process • mononuclear cell migration • lymphocyte migration • cell migration • T cell migration • cell motility • regulation of steroid biosynthetic process • regulation of cholesterol biosynthetic process • regulation of cholesterol metabolic process • steroid metabolic process • regulation of lipid metabolic process • sterol metabolic process • positive regulation of biological process • cholesterol metabolic process • lipid biosynthetic process • alcohol metabolic process • regulation of primary metabolic process • positive regulation of metabolic process • regulation of small molecule metabolic process • positive regulation of biosynthetic process • positive regulation of lipid metabolic process • small molecule metabolic process • steroid biosynthetic process • positive regulation of cellular process • regulation of biosynthetic process • secondary alcohol biosynthetic process • regulation of alcohol biosynthetic process • small molecule biosynthetic process • regulation of steroid metabolic process • cholesterol biosynthetic process • positive regulation of cholesterol biosynthetic process • primary metabolic process • secondary alcohol metabolic process • positive regulation of steroid biosynthetic process • biosynthetic process • sterol biosynthetic process • positive regulation of lipid biosynthetic process • regulation of sterol biosynthetic process • alcohol biosynthetic process • positive regulation of cholesterol metabolic process • positive regulation of steroid metabolic process • metabolic process • regulation of lipid biosynthetic process • positive regulation of small molecule metabolic process • regulation of metabolic process • positive regulation of alcohol biosynthetic process • positive regulation of sterol biosynthetic process • lipid metabolic process • regulation of cytoskeleton organization • regulation of cellular component organization • microtubule cytoskeleton organization • regulation of mitotic spindle organization • mitotic cell cycle • cellular component organization • cell cycle • cellular component organization or biogenesis • regulation of cell cycle • microtubule cytoskeleton organization involved in mitosis • spindle organization • cell cycle process • regulation of cell cycle process • regulation of microtubule-based process • regulation of spindle organization • regulation of organelle organization • mitotic spindle organization • organelle organization • mitotic cell cycle process • microtubule-based process • cytoskeleton organization • regulation of microtubule cytoskeleton organization • protein localization • positive regulation of protein localization to cell periphery • regulation of localization • protein localization to cell periphery • cellular localization • regulation of protein localization • positive regulation of protein localization to cell cortex • regulation of protein localization to cell periphery • localization • regulation of cellular localization • regulation of protein localization to cell cortex • cellular macromolecule localization • macromolecule localization • positive regulation of protein localization • protein localization to cell cortex • response to ketone • response to prostaglandin • response to lipid • response to alcohol • response to prostaglandin E • cellular response to forskolin • cellular response to oxygen-containing compound • cellular response to chemical stimulus • cellular response to alcohol • response to forskolin • cellular response to lipid • cellular response to ketone • midbody • nucleus • membrane-enclosed lumen • intracellular membraneless organelle • nucleolus • intracellular organelle lumen • organelle lumen • membraneless organelle • nuclear lumen • cell cortex • centrosome • microtubule organizing center • cytoskeleton • microtubule cytoskeleton • nucleoplasm • G-protein beta-subunit binding • fibroblast proliferation • cell population proliferation • cellular response to nitrogen compound • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to monoamine stimulus • cellular response to prostaglandin stimulus • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to hormone stimulus • identical protein binding • molecular transducer activity • G protein-coupled receptor activity • transmembrane signaling receptor activity • signaling receptor activity • cannabinoid receptor activity • developmental process • spermatogenesis • sexual reproduction • reproductive process • multicellular organismal reproductive process • developmental process involved in reproduction • male gamete generation • gamete generation • multicellular organismal process • regulation of penile erection • regulation of reproductive process • mating behavior • behavior • reproductive behavior • regulation of multicellular organismal process • penile erection • copulation • positive regulation of programmed cell death • regulation of apoptotic process • regulation of programmed cell death • cell death • positive regulation of apoptotic process • apoptotic process • programmed cell death • system process • learning or memory • nervous system process • cognition • memory • monoamine transport • nitrogen compound transport • negative regulation of amine transport • regulation of catecholamine secretion • transport • negative regulation of biological process • negative regulation of transport • organic hydroxy compound transport • dopamine transport • secretion by cell • regulation of secretion by cell • negative regulation of secretion • catecholamine transport • negative regulation of dopamine secretion • signal release • negative regulation of cellular process • negative regulation of secretion by cell • secretion • regulation of transport • export from cell • cell-cell signaling • negative regulation of catecholamine secretion • dopamine secretion • establishment of localization • regulation of secretion • catecholamine secretion • amine transport • regulation of amine transport • regulation of dopamine secretion • regulation of neuron projection development • positive regulation of cellular component organization • cellular developmental process • cell projection organization • cell development • neuron projection development • neurogenesis • multicellular organism development • neuron differentiation • positive regulation of neuron projection development • cell differentiation • anatomical structure development • positive regulation of cell projection organization • system development • plasma membrane bounded cell projection organization • regulation of cell projection organization • nervous system development • generation of neurons • neuron development • regulation of plasma membrane bounded cell projection organization • establishment of protein localization • regulation of biological quality • regulation of peptide hormone secretion • regulation of hormone levels • establishment of protein localization to extracellular region • protein secretion • regulation of protein secretion • regulation of hormone secretion • regulation of peptide secretion • hormone secretion • protein localization to extracellular region • peptide secretion • amide transport • regulation of signaling • regulation of peptide transport • regulation of establishment of protein localization • regulation of protein transport • peptide transport • protein transport • regulation of insulin secretion • peptide hormone secretion • hormone transport • regulation of cell communication • insulin secretion • positive regulation of acute inflammatory response to antigenic stimulus • regulation of defense response • regulation of acute inflammatory response to antigenic stimulus • regulation of response to external stimulus • positive regulation of acute inflammatory response • inflammatory response to antigenic stimulus • positive regulation of response to stimulus • positive regulation of response to external stimulus • positive regulation of inflammatory response • positive regulation of immune response • response to stress • regulation of response to stress • regulation of immune system process • acute inflammatory response • positive regulation of immune system process • defense response • immune response • regulation of inflammatory response to antigenic stimulus • response to external stimulus • regulation of inflammatory response • positive regulation of inflammatory response to antigenic stimulus • acute inflammatory response to antigenic stimulus • regulation of response to stimulus • positive regulation of defense response • regulation of acute inflammatory response • regulation of immune response • inflammatory response • neuron recognition • neuron projection fasciculation • axonal fasciculation • cell recognition • axon development • inorganic ion homeostasis • intracellular calcium ion homeostasis • homeostatic process • calcium ion homeostasis • regulation of cytosolic calcium ion concentration • regulation of presynaptic cytosolic calcium ion concentration • cellular homeostasis • neuron cellular homeostasis • chemical homeostasis • intracellular monoatomic cation homeostasis • monoatomic ion homeostasis • intracellular chemical homeostasis • monoatomic cation homeostasis • intracellular monoatomic ion homeostasis • regulation of behavior • feeding behavior • regulation of feeding behavior • glucose homeostasis • carbohydrate homeostasis • G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger • cannabinoid signaling pathway • negative regulation of monoatomic ion transport • monoatomic ion transport • serotonin secretion • negative regulation of serotonin secretion • regulation of monoatomic ion transport • serotonin transport • regulation of serotonin secretion • trans-synaptic signaling • synaptic transmission, GABAergic • modulation of chemical synaptic transmission • chemical synaptic transmission • synaptic signaling • regulation of trans-synaptic signaling • anterograde trans-synaptic signaling • regulation of synaptic transmission, GABAergic • multi-multicellular organism process • maternal process involved in female pregnancy • female pregnancy • multi-organism reproductive process • circulatory system process • regulation of blood pressure • positive regulation of blood pressure • blood circulation • response to ethanol • regulation of action potential • negative regulation of action potential • action potential • regulation of membrane potential • trans-synaptic signaling by endocannabinoid • retrograde trans-synaptic signaling • retrograde trans-synaptic signaling by endocannabinoid • trans-synaptic signaling by lipid • retrograde trans-synaptic signaling by lipid • regulation of leukocyte activation • cell activation • regulation of cell activation • myeloid leukocyte activation • leukocyte activation • negative regulation of cell activation • negative regulation of mast cell activation • negative regulation of immune system process • mast cell activation • regulation of mast cell activation • negative regulation of multicellular organismal process • negative regulation of leukocyte activation • synaptic transmission, glutamatergic • regulation of synaptic transmission, glutamatergic • response to nutrient levels • response to nutrient • response to nicotine • biological process involved in interspecies interaction between organisms • response to other organism • response to lipopolysaccharide • response to biotic stimulus • response to bacterium • response to external biotic stimulus • response to molecule of bacterial origin • response to cocaine • response to alkaloid • acute-phase response • regulation of heat generation • positive regulation of heat generation • heat generation • positive regulation of fever generation • fever generation • multicellular organismal-level homeostasis • temperature homeostasis • positive regulation of multicellular organismal process • regulation of fever generation • negative regulation of blood pressure • catabolic process • negative regulation of fatty acid oxidation • negative regulation of small molecule metabolic process • negative regulation of fatty acid beta-oxidation • oxoacid metabolic process • ketone metabolic process • organic acid metabolic process • organic acid catabolic process • regulation of fatty acid oxidation • monocarboxylic acid catabolic process • fatty acid oxidation • carboxylic acid catabolic process • fatty acid beta-oxidation • lipid oxidation • negative regulation of lipid catabolic process • negative regulation of catabolic process • fatty acid metabolic process • lipid catabolic process • negative regulation of fatty acid metabolic process • negative regulation of metabolic process • regulation of fatty acid beta-oxidation • carboxylic acid metabolic process • lipid modification • regulation of catabolic process • regulation of lipid catabolic process • regulation of ketone metabolic process • fatty acid catabolic process • regulation of fatty acid metabolic process • monocarboxylic acid metabolic process • small molecule catabolic process • negative regulation of lipid metabolic process • actin cytoskeleton • presynapse • presynaptic membrane • plasma membrane region • synaptic membrane • glutamatergic synapse • mitochondrial membrane • mitochondrion • organelle outer membrane • organelle envelope • mitochondrial envelope • mitochondrial outer membrane • outer membrane • membrane microdomain • membrane raft • growth cone • axon • distal axon • site of polarized growth • GABA-ergic synapse
SCOP2	Domain Identifier	• Ras-like P-loop GTPases • Transducin (heterotrimeric G protein), gamma chain • G protein-coupled receptor-like
SCOP2	Family Identifier	• Ras-like P-loop GTPases • Transducin (heterotrimeric G protein), gamma chain • G protein-coupled receptor-like
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	Q2B
PDB Residues	W:W:?1
Environment Details	Open EMBL-EBI Page
Code	Q2B
Name	3-[(1S)-1-(furan-2-yl)-2-nitro-ethyl]-2-phenyl-1H-indole
Synonyms
Identifier
Formula	C20 H16 N2 O3
Molecular Weight	332.353
SMILES
PubChem	703205
Formal Charge	0
Total Atoms	41
Total Chiral Atoms	1
Total Bonds	44
Total Aromatic Bonds	21


PDBsum	Open PDBsum Page
Chain	A
Protein	G Protein α Sub unit
UniProt	P63096
Sequence	>8IKG_Chain_A T L S A E D K A A V E R S K M I D R N L R E D G E K A A R E V K L L L L G A G E S G K S T I V K Q M K T G I V E T H F T F K D L H F K M F D V G G Q R S E R K K W I H C F E G V T A I I F C V A L S D Y D L V N R M H E S M K L F D S I C N N K W F T D T S I I L F L N K K D L F E E K I K K S P L T I C Y P E Y A G S N T Y E E A A A Y I Q C Q F E D L N K R K D T K E I Y T H F T C A T D T K N V Q F V F D A V T D V I I K N N L K D C G L F Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

Chain	B
Protein	G Protein β Sub unit
UniProt	P62873
Sequence	>8IKG_Chain_B E L D Q L R Q E A E Q L K N Q I R D A R K D A T L S Q I T N N I D P V G R I Q M R T R R T L R G H L A K I Y A M H W G T D S R L L V S G K L I I W D S Y T T N K V H A I P V M T C A Y A P S G N Y V A C G G L D N I C S I Y N L K T R E G N V R V S R E L A G H T G Y L S C C R F L D D N Q I V T S S G D T T C A L W D I E T G Q Q T T T F T G T G D V M S L S L A P D T R L F V S G A C D A S A K L W D V R E G M C R Q T F T G E S D I N A I C F F P N G N A F A T G S D D A T C R L F D L R A D Q E L M T Y S H D N I I C G I T S V S F S K S G R L L L A G Y D D F N C N V W D A L K A D R A G V L A G H D N R V S C L G V T D D G M A V A T G S W D S F L K I W N Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

Chain	G
Protein	G Protein γ Sub unit
UniProt	P59768
Sequence	>8IKG_Chain_G A S I A Q A R K L V E Q L K M E A N I D R I K V S K A A A D L M A Y C E A H A K E D P L L T P V P P F R E Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

Chain	R
Protein	Receptor
UniProt	P21554
Sequence	>8IKG_Chain_R M V L N P S Q Q L A I A V L S L T L G T F T V L E N L L V L C V I L H S R S L R C R P S Y H F I G S L A V A D L L G S V I F V Y S F I D F H V F H R K D S R N V F L F K L G G V T A S F T A S V G S L F L T A I D R Y I S I H R P L A Y K R I V T R P K A V V A F C L M W T I A I V I A V L P L L G W N C C S D I F P H I D E T Y L M F W I G V T S V L L L F I V Y A Y M Y I L W K A H S H A V R M I Q R G T Q K A R M D I R L A K T L V L I L V V L I I C W G P L L A I M V Y D V F G K M N K L I K T V F A F C S M L C L L N S T V N P I I Y A L R S K D L R H A F Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	9B65	A	Lipid	Cannabinoid	CB₁	Homo sapiens	KCA	-	Gi1/β1/γ2	3.03	2025-03-05	10.1038/s41586-025-08618-7
	9B54	A	Lipid	Cannabinoid	CB₁	Homo sapiens	A1AIW	-	Gi1/β1/γ2	2.86	2025-03-05	10.1038/s41586-025-08618-7
	9BA0	A	Lipid	Cannabinoid	CB₁	Homo sapiens	A1AKN	-	-	3.13	2024-11-20	10.1038/s41467-024-54206-0
	9B9Z	A	Lipid	Cannabinoid	CB₁	Homo sapiens	A1AKO	-	-	3.3	2024-11-20	10.1038/s41467-024-54206-0
	9B9Y	A	Lipid	Cannabinoid	CB₁	Homo sapiens	7DY	-	-	3.5	2024-11-20	10.1038/s41467-024-54206-0
	9ERX	A	Lipid	Cannabinoid	CB₁	Homo sapiens	D9-THC analog	-	Gi1/β1/γ2	2.9	2024-06-26	10.21203/rs.3.rs-4277209/v1
	8IKH	A	Lipid	Cannabinoid	CB₁	Homo sapiens	-	Q2L	Gi1/β1/γ1	3.3	2024-06-05	10.1073/pnas.2321532121
	8WU1	A	Lipid	Cannabinoid	CB₁	Homo sapiens	PubChem 119025665	-	Arrestin2	3.2	2024-03-20	To be published
	8WRZ	A	Lipid	Cannabinoid	CB₁	Homo sapiens	PubChem 102336704	-	Arrestin2	3.6	2024-02-28	10.1093/procel/pwad055
	8GAG	A	Lipid	Cannabinoid	CB₁	Homo sapiens	PubChem 170838490	-	Gi1/β1/γ2	3.3	2024-02-28	To be published
	8K8J	A	Lipid	Cannabinoid	CB₁	Homo sapiens	Fenofibrate	-	chim(Gs-CtGq)/β1/γ2	2.88	2024-02-14	10.1002/advs.202306311
	8GHV	A	Lipid	Cannabinoid	CB₁	Homo sapiens	AMG315	-	Gi1/β1/γ2	2.8	2023-05-24	10.1038/s41467-023-37864-4
	7FEE	A	Lipid	Cannabinoid	CB₁	Homo sapiens	CP55940	ZCZ011	-	2.7	2022-06-15	10.1038/s41589-022-01038-y
	7WV9	A	Lipid	Cannabinoid	CB₁	Homo sapiens	CP55940	ZCZ011	Gi2/β1/γ2	3.36	2022-06-15	10.1038/s41589-022-01038-y
	7V3Z	A	Lipid	Cannabinoid	CB₁	Homo sapiens	CP55940	-	-	3.29	2021-11-24	10.1021/jacs.1c06847
	6KPG	A	Lipid	Cannabinoid	CB₁	Homo sapiens	AM841	-	Gi1/β1/γ2	3	2020-02-12	10.1016/j.cell.2020.01.008
	6KQI	A	Lipid	Cannabinoid	CB₁	Homo sapiens	CP55940	Org27569	-	3.25	2019-10-23	10.1038/s41589-019-0387-2
	6N4B	A	Lipid	Cannabinoid	CB₁	Homo sapiens	MDMB-Fubinaca	-	Gi1/β1/γ2	3	2019-01-30	10.1016/j.cell.2018.11.040
	5XRA	A	Lipid	Cannabinoid	CB₁	Homo sapiens	AM11542	-	-	2.8	2017-07-12	10.1038/nature23272
	5XR8	A	Lipid	Cannabinoid	CB₁	Homo sapiens	AM841	-	-	2.95	2017-07-12	10.1038/nature23272
	5U09	A	Lipid	Cannabinoid	CB₁	Homo sapiens	Taranabant	-	-	2.6	2016-12-07	10.1038/nature20613
	5TGZ	A	Lipid	Cannabinoid	CB₁	Homo sapiens	AM6538	-	-	2.8	2016-11-02	10.1016/j.cell.2016.10.004

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