Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg Int. Strength Num Of Links Community ConSurf
1A:A:L5 3.5075402
2A:A:L36 4.774157
3A:A:L39 5.5075409
4A:A:F196 8.9545157
5A:A:F199 9.074515
6A:A:S206 6.145418
7A:A:K210 7.724519
8A:A:W211 7.495619
9A:A:F223 6.135409
10A:A:Y230 6.726538
11A:A:L249 5.29409
12A:A:F250 6.61714739
13A:A:W258 8.5325105
14A:A:F259 5.61419
15A:A:F274 5.402539
16A:A:Y287 7.5465177
17A:A:Y290 8.1325407
18A:A:F307 4.91714738
19A:A:Y320 7.472507
20A:A:F323 5.19434
21A:A:T324 5.234189
22A:A:F336 5.706508
23A:A:L353 6.6175407
24A:A:F354 8.1954145
25B:B:V40 5.4754123
26B:B:H54 8.336676199
27B:B:Y59 9.2085108
28B:B:W63 6.74833667
29B:B:D76 5.3254199
30B:B:W82 11.844509
31B:B:N88 5.9175407
32B:B:K89 7.848509
33B:B:H91 5.87455
34B:B:I93 6.53457
35B:B:L95 5.055458
36B:B:W99 7.285819
37B:B:Y105 4.67656
38B:B:N110 6.53414
39B:B:Y111 6.87514
40B:B:L117 4.865419
41B:B:I123 4.795416
42B:B:Y124 4.63714756
43B:B:H142 8.254519
44B:B:Y145 6.07667918
45B:B:F151 5.24619
46B:B:Q156 5.0045205
47B:B:T159 5.965419
48B:B:D163 9.435419
49B:B:C166 4.356548
50B:B:L168 4.6575406
51B:B:W169 11.2475418
52B:B:Q176 6.88414
53B:B:F180 8.312547
54B:B:H183 8.878549
55B:B:D186 4.8175419
56B:B:F199 8.412549
57B:B:K209 12.63446
58B:B:W211 9.592548
59B:B:Q220 7.695427
60B:B:F222 7.5075428
61B:B:H225 9.28667629
62B:B:D228 8.955419
63B:B:F234 4.794505
64B:B:F235 7.1625136
65B:B:P236 6.0154137
66B:B:F241 6.95626
67B:B:T243 4.835428
68B:B:D246 6.546519
69B:B:D247 6.446529
70B:B:T249 5.155426
71B:B:R251 13.385428
72B:B:F253 7.79426
73B:B:D258 8.6575427
74B:B:M262 4.54404
75B:B:Y264 6.188505
76B:B:F278 5.786137
77B:B:R283 9.744129
78B:B:L284 5.7925405
79B:B:Y289 7.304297217
80B:B:V296 3.74505
81B:B:D298 9.1854129
82B:B:K301 5.05754125
83B:B:R304 11.155405
84B:B:H311 8.622599
85B:B:R314 15.07754108
86B:B:V315 3.99497
87B:B:L318 3.4675406
88B:B:W332 12.61147109
89B:B:D333 5.688599
90B:B:K337 6.295496
91B:B:W339 9.88599
92B:B:N340 6.6525469
93G:G:Y40 11.4154136
94G:G:D48 7.1775409
95G:G:F61 6.96667668
96L:L:?1 13.27770
97R:R:L52 4.61754228
98R:R:N59 8.292508
99R:R:F61 9.142588
100R:R:Y64 8.322508
101R:R:D72 8.3175409
102R:R:F75 5.0465116
103R:R:M79 5.05405
104R:R:R103 10.22574
105R:R:Y109 7.2525118
106R:R:S126 6.42488
107R:R:W132 5.825486
108R:R:F133 6.53429787
109R:R:R137 7.7925489
110R:R:W150 6.7325409
111R:R:S165 6.105473
112R:R:R174 7.165401
113R:R:L190 5.0625408
114R:R:R213 8.161676145
115R:R:C233 2.73507
116R:R:Y240 7.186503
117R:R:F242 7.875405
118R:R:W246 9.762574
119R:R:N272 5.974239
120R:R:Y276 6.1645239
121R:R:F277 5.614507
122R:R:R282 5.9125405
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
1B:B:L70 B:B:W82 14.24065.69NoYes059
2B:B:L70 B:B:M61 12.84394.24NoNo656
3B:B:C317 B:B:M61 33.31764.86NoNo076
4B:B:C317 B:B:S316 33.50873.44NoNo079
5B:B:S316 B:B:W332 33.70024.94NoYes099
6B:B:W332 B:B:Y59 40.740112.54YesYes1098
7B:B:Q75 B:B:Y59 42.484912.4NoYes098
8B:B:Q75 B:B:W99 42.69365.48NoYes099
9B:B:S97 B:B:W99 10.67283.71NoYes089
10B:B:D118 B:B:S97 10.399111.78NoNo098
11B:B:D118 B:B:I120 10.12588.4NoNo096
12A:A:F215 B:B:W99 37.747512.03NoYes199
13A:A:F215 A:A:L37 39.1812.18NoNo099
14A:A:L37 A:A:L39 39.2355.54NoYes099
15A:A:F223 A:A:L39 40.49843.65YesYes099
16A:A:F223 A:A:F250 10011.79YesYes099
17A:A:F250 A:A:L266 94.43987.31YesNo399
18A:A:L266 A:A:L268 95.10044.15NoNo398
19A:A:L227 A:A:L268 94.50489.69NoNo378
20A:A:F274 A:A:L227 95.04013.65YesNo397
21A:A:F274 A:A:Y296 96.59145.16YesNo094
22A:A:K271 A:A:Y296 96.54133.58NoNo054
23A:A:C325 A:A:K271 96.51578.08NoNo075
24A:A:C325 A:A:D328 96.46324.67NoNo079
25A:A:D328 A:A:T324 96.43647.23NoYes099
26A:A:H322 A:A:T324 95.51784.11NoYes1899
27A:A:F334 A:A:H322 95.984321.5NoNo039
28A:A:F334 A:A:Y320 95.95096.19NoYes037
29A:A:E318 A:A:Y320 95.813113.47NoYes047
30A:A:E318 R:R:R213 95.77766.98NoYes045
31A:A:K345 R:R:R213 28.3054.95NoYes1455
32A:A:K345 A:A:K349 28.18125.75NoNo1455
33A:A:K349 R:R:R282 56.23987.43NoYes055
34A:A:D350 R:R:R282 24.54628.34NoYes045
35A:A:D350 R:R:N59 24.316812.12NoYes048
36R:R:N59 R:R:P60 26.52486.52YesNo087
37R:R:P60 R:R:R137 14.88015.76NoYes879
38A:A:F354 R:R:R213 67.326411.76YesYes1455
39A:A:F354 A:A:K349 28.38446.2YesNo1455
40R:R:R282 R:R:R283 31.35344.26YesNo056
41R:R:N59 R:R:R283 26.3067.23YesNo086
42R:R:F133 R:R:P60 11.04545.78YesNo877
43R:R:F133 R:R:W132 22.49674.01YesYes876
44R:R:F61 R:R:N59 22.99510.87YesYes088
45R:R:F133 R:R:F61 13.85747.5YesYes878
46A:A:F354 A:A:L348 39.31683.65YesNo059
47A:A:L348 R:R:L219 39.20224.15NoNo097
48A:A:L353 R:R:L219 37.52311.07YesNo077
49B:B:L117 B:B:W99 13.45654.56YesYes199
50B:B:L117 B:B:Y145 13.51193.52YesYes198
51A:A:W211 B:B:Y145 59.81226.75YesYes198
52A:A:R208 A:A:W211 59.59969NoYes099
53A:A:L249 A:A:R208 59.56994.86YesNo099
54A:A:F223 A:A:L249 59.63946.09YesYes099
55A:A:K210 B:B:Y145 61.74753.58YesYes198
56A:A:K210 B:B:D246 60.60985.53YesYes199
57A:A:L353 R:R:R123 32.56436.07YesNo079
58B:B:D246 B:B:S227 60.61064.42YesNo096
59B:B:D247 B:B:S227 60.45215.89YesNo096
60B:B:D247 B:B:H225 58.63843.78YesYes299
61B:B:H225 B:B:T243 57.57415.48YesYes298
62B:B:F241 B:B:T243 41.01963.89YesYes268
63B:B:F241 B:B:V200 26.788811.8YesNo266
64B:B:F234 B:B:V200 26.60726.55YesNo056
65B:B:A193 B:B:F234 28.16974.16NoYes045
66B:B:A193 B:B:D195 27.91423.09NoNo045
67B:B:D195 B:B:R197 27.65843.57NoNo055
68B:B:R197 B:B:R214 27.402119.19NoNo059
69B:B:D212 B:B:R214 14.61811.91NoNo099
70B:B:M217 G:G:M21 13.20852.89NoNo031
71G:G:E17 G:G:M21 12.63878.12NoNo061
72G:G:E17 G:G:K20 12.06854.05NoNo066
73B:B:L14 G:G:K20 11.49792.82NoNo086
74B:B:F222 B:B:F241 19.16077.5YesYes286
75B:B:D258 B:B:F222 33.46094.78YesYes278
76B:B:F253 B:B:T243 16.53263.89YesYes268
77B:B:F222 B:B:F253 16.485210.72YesYes286
78B:B:D258 B:B:R22 34.01127.15YesNo076
79B:B:Q259 B:B:R22 33.55733.5NoNo066
80B:B:T321 B:B:W63 14.186210.92NoYes677
81B:B:D323 B:B:T321 13.70955.78NoNo677
82B:B:D323 B:B:M325 13.5098.32NoNo075
83B:B:M325 G:G:P49 12.15465.03NoNo057
84G:G:D48 G:G:P49 11.03924.83YesNo097
85B:B:G162 B:B:Y145 17.46310.14NoYes198
86B:B:G162 B:B:S161 17.24373.71NoNo199
87B:B:H142 B:B:S161 15.628816.74YesNo199
88B:B:H142 B:B:T159 14.6575.48YesYes199
89B:B:I157 B:B:T159 10.92263.04NoYes179
90B:B:R214 B:B:V213 13.51013.92NoNo094
91B:B:L168 B:B:V213 13.2324.47YesNo064
92B:B:L285 B:B:Y264 16.04013.52NoYes065
93B:B:F278 B:B:L285 14.171110.96YesNo076
94B:B:L252 B:B:Y264 29.32835.86NoYes075
95B:B:L252 B:B:L261 29.71839.69NoNo075
96B:B:D254 B:B:L261 30.11658.14NoNo095
97B:B:A257 B:B:D254 30.91284.63NoNo079
98B:B:Q259 G:G:V30 32.650710.03NoNo068
99R:R:R123 R:R:Y276 32.42358.23NoYes099
100R:R:L116 R:R:Y276 13.30424.69NoYes2399
101R:R:F230 R:R:L116 13.31964.87NoNo099
102R:R:F230 R:R:M194 12.007811.2NoNo098
103R:R:M194 R:R:T117 11.66626.02NoNo088
104R:R:L190 R:R:T117 11.32798.84YesNo088
105R:R:I186 R:R:L190 10.00474.28NoYes078
106R:R:F242 R:R:I186 10.20273.77YesNo057
107R:R:N272 R:R:Y276 20.52665.81YesYes2399
108R:R:D72 R:R:N272 17.22036.73YesYes099
109R:R:D72 R:R:S269 16.396110.31YesNo099
110R:R:F75 R:R:S269 16.03586.61YesNo1169
111R:R:F75 R:R:M79 11.47944.98YesYes065
112R:R:F129 R:R:W132 21.49522NoYes056
113R:R:F129 R:R:L128 19.34754.87NoNo056
114R:R:C124 R:R:L128 12.90193.17NoNo086
115B:B:M61 B:B:W63 20.2834.65NoYes667
116B:B:A257 G:G:V30 31.3115.09NoNo078
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


2D representation of the interactions of this orthosteric/allosteric ligand.


Links and nodes colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
L:L:?1 R:R:R103 11.34 7 Yes Yes 0 4 0 1
L:L:?1 R:R:C164 14.81 7 Yes No 0 6 0 1
L:L:?1 R:R:C175 7.41 7 Yes No 0 8 0 1
L:L:?1 R:R:D179 11.08 7 Yes No 0 3 0 1
L:L:?1 R:R:W241 27.9 7 Yes No 0 4 0 1
L:L:?1 R:R:Y245 15.04 7 Yes No 0 4 0 1
L:L:?1 R:R:W246 5.31 7 Yes Yes 0 4 0 1
R:R:E99 R:R:R103 15.12 7 No Yes 5 4 2 1
R:R:E99 R:R:S165 8.62 7 No Yes 5 3 2 2
R:R:K102 R:R:R103 6.19 0 No Yes 3 4 2 1
R:R:R103 R:R:S161 10.54 7 Yes No 4 3 1 2
R:R:R103 R:R:S165 7.91 7 Yes Yes 4 3 1 2
R:R:W241 R:R:Y106 39.55 7 No No 4 3 1 2
R:R:S161 R:R:S165 4.89 7 No Yes 3 3 2 2
R:R:C164 R:R:C175 7.28 7 No No 6 8 1 1
R:R:C175 R:R:W246 5.22 7 No Yes 8 4 1 1
R:R:F176 R:R:W246 19.04 0 No Yes 2 4 2 1
R:R:D179 R:R:F242 7.17 7 No Yes 3 5 1 2
R:R:D179 R:R:W246 6.7 7 No Yes 3 4 1 1
R:R:W241 R:R:Y245 3.86 7 No No 4 4 1 1
R:R:W246 R:R:Y245 12.54 7 Yes No 4 4 1 1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

ShowSimilarityNetwork TypeNameLigandDescription
85.71Single7Y14Beta-Alanine7Y14-MRGPRD-β-Alanine
46.15Single9DQHEP-28259DQH-MRGPRD-EP-2825-chim(NtGi1-Gs-CtGq)/β1/γ2
44.44Single7VDMSubstance-P7VDM-MRGPRX2-Substance-P-Gi1/β1/γ2
37.50Single8JGBConorfamide-Tx28JGB-MRGPRX1-Conorfamide-Tx2-Gi1/β1/γ2
30.77Single9DQJEP-39459DQJ-MRGPRD-EP-3945-chim(NtGi1-Gs-CtGq)/β1/γ2
26.67Single7VV0PAMP-127VV0-MRGPRX2-PAMP-12
26.32Single8DWGProenkephalin-A8DWG-MRGPRX1-Proenkephalin-A-ML382-chim(NtGi2L-Gs-CtGq)/β1/γ2
25.00Single7S8NR-Zinc-35737S8N-MRGPRX2-R-Zinc-3573-chim(NtGi2L-Gs-CtGq)/β1/γ2
25.00Single7S8OR-Zinc-35737S8O-MRGPRX2-R-Zinc-3573-Gi1/β1/γ2
25.00Single7VDHC48/807VDH-MRGPRX2-C48/80-Gi1/β1/γ2
25.00Single8JGFBAM8-228JGF-MRGPRX1-BAM8-22-chim(NtGi1-Gs-CtGq)/β1/γ2
23.53Single8DWCProenkephalin-A8DWC-MRGPRX1-Proenkephalin-A-chim(NtGi2L-Gs-CtGq)/β1/γ2
23.08Single7VDLCortistatin-147VDL-MRGPRX2-Cortistatin-14-Gi1/β1/γ2
23.08Single7VV5C48/807VV5-MRGPRX2-C48/80-Gi1/β1/γ2
21.43Single7VV6C48/807VV6-MRGPRX2-C48/80
21.43Single8HJ5PubChem 1390305318HJ5-MRGPRX1-PubChem 139030531-chim(NtGi1-Gs-CtGq)/β1/γ2
18.75Single8JGGBAM8-228JGG-MRGPRX1-BAM8-22-Gi1/β1/γ2
17.65Single7S8MCortistatin-147S8M-MRGPRX2-Cortistatin-14-Gi1/β1/γ2
15.79Single9JH5C16:0 Ceramide9JH5-CysLT2-C16:0 Ceramide-chim(NtGi1-Gs-CtGq)/β1/γ2
15.38Single7XP6Strychnine7XP6-TAS2R46-Strychnine-chim(Gs-CtGt3)/β1/γ2
15.00Single7S8LCortistatin-147S8L-MRGPRX2-Cortistatin-14-chim(NtGi2L-Gs-CtGq)/β1/γ2
14.29Single8DWHPubChem 1390305318DWH-MRGPRX1-PubChem 139030531-chim(NtGi2L-Gs-CtGq)/β1/γ2
14.29Single8IZBLysophosphatidylserine8IZB-GPR174-Lysophosphatidylserine-Gs/β1/γ2
14.29Single8T3SButyric acid8T3S-FFA2-Butyric acid-chim(NtGi2L-Gs-CtGq)/β1/γ2
13.64Single9IQRMuscarinic toxin 39IQR-α2a-Muscarinic toxin 3
13.33Single7UTZDPPC7UTZ-TSH-TR1402-DPPC-Gs/β1/γ2
13.33Single8K4NVF08K4N-GPR34-VF0-Gi1/β1/γ2
12.50Single7PP1Selatogrel7PP1-P2Y12-Selatogrel
12.50Single8XBGS3E-LysoPS8XBG-GPR34-S3E-LysoPS
12.50Single9IYAONO-97105319IYA-GPR55-ONO-9710531
12.00Single7XV3Lysophosphatidylserine7XV3-GPR174-Lysophosphatidylserine-chim(NtGi1-Gs)/β1/γ2
11.76Single4NTJAZD12834NTJ-P2Y12-AZD1283
11.76Single5ZBQUR-MK-2995ZBQ-Y1-UR-MK-299
11.76Single6HLPNetupitant6HLP-NK1-Netupitant
11.76Single6RZ4Pranlukast6RZ4-CysLT1-Pranlukast-Na
11.76Single7E9GJNJ-404118137E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/β1/γ2
11.76Single7VV4Cortistatin-147VV4-MRGPRX2-Cortistatin-14
11.76Single8IZ4Lysophosphatidylserine8IZ4-GPR34-Lysophosphatidylserine-Gi1/β1/γ2
11.76Single8ZYTNeurotensin peptide 8-138ZYT-NTS1-Neurotensin peptide 8-13-SBI-553-Arrestin2
11.76Single9GE2ML1849GE2-GPR55-ML184-chim(NtGi1-G13)/β1/γ2
11.76Consensuscyslt_offOrthosteric Ligandcyslt2_off cyslt1_off
11.11Single5ZBHBMS-1938855ZBH-Y1-BMS-193885
11.11Single6KO5PubChem 574000026KO5-Ghrelin-PubChem 57400002
11.11Single7F58THIQ7F58-MC4-THIQ-Gs/β1/γ2
11.11Single7R0CAVP7R0C-V2-AVP-Arrestin2
11.11Single7Y24Octreotide7Y24-SST2-Octreotide-Go/β1/γ2
11.11Single8I2GCompound 7163408I2G-FSH-Glycoprotein hormones α chain-Compound 716340-Gs/β1/γ2
11.11Single8JSRAnamorelin8JSR-Ghrelin-Anamorelin-chim(NtGi1-Gs-CtGq)/β1/γ2
11.11Single8XBIS3E-LysoPS8XBI-GPR34-S3E-LysoPS
11.11Single9UY3Anamorelin9UY3-Ghrelin-Anamorelin-chim(NtGi1-Gs-CtGq)/β1/γ2
11.11Consensusffa_onOrthosteric Ligandffa2_on ffa3_on
11.11Consensusffa_on_gpOrthosteric Ligandffa2_on_gp ffa3_on_gp
11.11Consensusgi_ffaOrthosteric Ligand8J21-FFA3-Butyric acid-Gi1/β1/γ2 8J22-FFA2-TUG-1375-Gi1/β1/γ2
11.11Consensusnpy1_offOrthosteric Ligand5ZBH-Y1-BMS-193885 5ZBQ-Y1-UR-MK-299
11.11Consensusnpy_offOrthosteric Ligandnpy1_off npy2_off
11.11Consensusp2y12_onOrthosteric Ligand7XXI-P2Y12-2MeSADP-Gi2/β1/γ2
10.71Single8KGGLPS8KGG-P2Y10-LPS-chim(NtGi2-G13)/β1/γ2
10.53Single3VW7Vorapaxar; Na3VW7-PAR1-Vorapaxar; Na
10.53Single4PXZ2MeSADP4PXZ-P2Y12-2MeSADP
10.53Single6RZ7ONO-25703666RZ7-CysLT2-ONO-2570366
10.53Single7EXDLasmiditan7EXD-5-HT1F-Lasmiditan-Gi1/β1/γ2
10.53Single7F55Bremelanotide7F55-MC4-Bremelanotide-Gs/β1/γ2
10.53Single7XW5ML1097XW5-TSH-TSH-ML109-Gs/β1/γ2
10.53Single7XW6ML1097XW6-TSH-M22 Fab-ML109-Gs/β1/γ2
10.53Single7XW9TRH7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/β1/γ2
10.53Single7XXI2MeSADP7XXI-P2Y12-2MeSADP-Gi2/β1/γ2
10.53Single8ID9Eicosapentaenoic acid8ID9-FFA4-Eicosapentaenoic acid-Gi1/β1/γ2
10.53Single8WRBLysophosphatidylserine8WRB-GPR34-Lysophosphatidylserine-Gi1/β1/γ2
10.53Consensus5ht1f_onOrthosteric Ligand7EXD-5-HT1F-Lasmiditan-Gi1/β1/γ2
10.53Consensus5ht1f_on_gpOrthosteric Ligand7EXD-5-HT1F-Lasmiditan-Gi1/β1/γ2
10.53Consensusgi_p2yOrthosteric Ligand7XXI-P2Y12-2MeSADP-Gi2/β1/γ2
10.53Consensusp2y12_on_gpOrthosteric Ligand7XXI-P2Y12-2MeSADP-Gi2/β1/γ2
10.53Consensustrh_onOrthosteric Ligand7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/β1/γ2
10.53Consensustrh_on_gpOrthosteric Ligand7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/β1/γ2
10.00Single5MZPCaffeine5MZP-A2A-Caffeine-Na
10.00Single5TUDErgotamine5TUD-5-HT2B-Ergotamine
10.00Single6RZ9ONO-27703726RZ9-CysLT2-ONO-2770372
10.00Single8XBES3E-LysoPS8XBE-GPR34-S3E-LysoPS-Gi1/β1/γ1
10.00Single8ZX4Lysophosphatidylinositol 8ZX4-GPR55-Lysophosphatidylinositol-chim(NtGi1-G13)/β1/γ2
10.00Consensuscyslt2_offOrthosteric Ligand6RZ7-CysLT2-ONO-2570366 6RZ8-CysLT2-ONO-2080365 6RZ9-CysLT2-ONO-2770372
9.52Single6RZ6ONO-25703666RZ6-CysLT2-ONO-2570366
9.52Single7F9ZGHRP-67F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/β1/γ2
9.52Single8H4IDoconexent8H4I-FFA4-Doconexent-chim(NtGi1-Gs)/β1/γ2
9.52Single8J22TUG-13758J22-FFA2-TUG-1375-Gi1/β1/γ2
9.52Single8SAI1-Oleoyl-2-Hydroxy-Sn-Glycero-3-Phospho-L-Serine8SAI-GPR34-1-Oleoyl-2-Hydroxy-Sn-Glycero-3-Phospho-L-Serine-Gi1/β1/γ2
9.52Single9CM7TUG-13759CM7-FFA2-TUG-1375-AZ-1729-Gi1/β1/γ2
9.52Single9JF4PD1683689JF4-BB1-PD168368
9.52Single9NS9TUG-13759NS9-FFA2-TUG-1375-Compound 187-Gi1/β1/γ2
9.09Single5MZJTheophylline5MZJ-A2A-Theophylline-Na
9.09Single6RZ8ONO-20803656RZ8-CysLT2-ONO-2080365
9.09Single7F54Afamelanotide7F54-MC4-Afamelanotide-Gs/β1/γ2
9.09Single7XAUOctreotide7XAU-SST2-Octreotide-Gi1/β1/γ2
9.09Single8G59TUG-8918G59-FFA4-TUG-891-chim(Gi1-CtGq)/β1/γ2
9.09Single8PWNTheophylline8PWN-A2A-Theophylline
9.09Single8WKYPG-9348WKY-MC4-PG-934
9.09Single8WZ2Orexigenic Neuropeptide QRFP8WZ2-QRFP-Orexigenic Neuropeptide QRFP-chim(NtGi1L-Gs-CtGq)/β1/γ2
9.09Single8XBHS3E-LysoPS8XBH-GPR34-S3E-LysoPS-Gi1/β1/γ2
9.09Single8ZCJPasireotide8ZCJ-SST5-Pasireotide-Gi1/β1/γ1
9.09Single9J0IUDP-Glucuronic acid9J0I-P2Y14-UDP-Glucuronic acid-Gi1/β1/γ2
9.09Single9L3YRetinoic acid receptor responder protein 29L3Y-CML2-Retinoic acid receptor responder protein 2-Gi1/β1/γ2
9.09Consensusgi_nucleotideOrthosteric Ligandgi_adenosine gi_p2y
9.09Consensusmc4_onOrthosteric Ligand7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2 7F58-MC4-THIQ-Gs/β1/γ2 7F54-MC4-Afamelanotide-Gs/β1/γ2 7F53-MC4-α-MSH-Gs/β1/γ2 7F55-MC4-Bremelanotide-Gs/β1/γ2
8.70Single7PIVSetmelanotide7PIV-MC4-Setmelanotide-Gs/β1/γ2
8.70Single7XMSSomatostatin-147XMS-SST4-Somatostatin-14-Gi1/β1/γ2
8.70Single8IOCGamma-MSH8IOC-MC3-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
8.70Single8K6OPro-neuropeptide-Y8K6O-Y1-Pro-neuropeptide-Y-Gi2/β1/γ1
8.70Single8KH5Lysophosphatidylserine8KH5-GPR174-Lysophosphatidylserine-Gs/β1/γ2
8.70Single9IK8SST analogue9IK8-SST1-SST analogue-Gi1/β1/γ2
8.70Single9J0FNADH9J0F-P2Y14-NADH-Gi1/β1/γ2
8.70Consensusghrelin_onOrthosteric Ligand7NA7-Ghrelin-Ghrelin-27-Gi1/β1/γ2 7F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/β1/γ2 7NA8-Ghrelin-PubChem 178024-Gi1/β1/γ2
8.70Consensusghrelin_on_gpOrthosteric Ligand7NA7-Ghrelin-Ghrelin-27-Gi1/β1/γ2 7F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/β1/γ2 7NA8-Ghrelin-PubChem 178024-Gi1/β1/γ2
8.70Consensusmc4_on_gpOrthosteric Ligand7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2 7F58-MC4-THIQ-Gs/β1/γ2 7F54-MC4-Afamelanotide-Gs/β1/γ2 7F53-MC4-α-MSH-Gs/β1/γ2 7F55-MC4-Bremelanotide-Gs/β1/γ2
8.33Single3RFMCaffeine3RFM-A2A-Caffeine
8.33Single6OT025(S)-Epoxycholesterol6OT0-SMO-25(S)-Epoxycholesterol-Gi1/β1/γ2
8.33Single6OY9All-trans-Retinal6OY9-Rhodopsin-All-trans-Retinal-Gt/β1/γ1
8.33Single6W25SHU91196W25-MC4-SHU9119-Ca
8.33Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
8.33Single7RYCOxytocin7RYC-OT-Oxytocin-chim(NtGi2L-Gs-CtGq)/β1/γ2
8.33Single7XOUCholecystokinin-87XOU-CCKA-Cholecystokinin-8-Gs/β1/γ2
8.33Single8A2OTheophylline8A2O-A2A-Theophylline-Na
8.33Single8IKGQ2B8IKG-CB1-Q2B-Gi1/β1/γ1
8.33Single8K6MNeuropeptide-Y8K6M-Y1-Neuropeptide-Y-Gi2/β1/γ1
8.33Single8K6NPro-neuropeptide-Y8K6N-Y2-Pro-neuropeptide-Y-Gi2/β1/γ1
8.33Single8WKZSBL-MC-318WKZ-MC4-SBL-MC-31
8.33Single9C2FCa; Ca; Tryptophan; '54149; PO49C2F-CaS-Ca-Ca; Ca; Tryptophan; '54149; PO4
8.33Single9K27PrRP319K27-PrRP-PrRP31-chim(NtGi1-Gq)/β1/γ2
8.33Single9U4WGonadoliberin-19U4W-GnRH1-Gonadoliberin-1-chim(NtGi1L-Gs-CtGq)/β1/γ2
8.33Consensusmc3_onOrthosteric Ligand8IOC-MC3-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
8.33Consensusmc3_on_gpOrthosteric Ligand8IOC-MC3-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
8.33Consensusnpy1_onOrthosteric Ligand8K6M-Y1-Neuropeptide-Y-Gi2/β1/γ1
8.33Consensusnpy1_on_gpOrthosteric Ligand8K6M-Y1-Neuropeptide-Y-Gi2/β1/γ1
8.00Single7KH0AVP7KH0-V2-AVP-chim(NtGi1-Gs)/β1/γ2
8.00Single8XZJWN3538XZJ-Apelin-WN353-Gi1/β1/γ2
8.00Consensusp2y_on_gpOrthosteric Ligandp2y1_on_gp p2y10_on_gp p2y12_on_gp
7.69Single3UZAGTPL92363UZA-A2A-GTPL9236
7.69Single6FK9PubChem 1324730366FK9-Rhodopsin-PubChem 132473036
7.69Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
7.69Single7V6APubChem 98642757V6A-M4-PubChem 9864275-Gi1/β1/γ2
7.69Single7WC5Psilocin7WC5-5-HT2A-Psilocin
7.69Single7X9BNeuropeptide-Y7X9B-Y2-Neuropeptide-Y-Gi1/β1/γ2
7.69Single7X9CPancreatic Hormone7X9C-Y4-Pancreatic Hormone-Gi1/β1/γ2
7.69Single8F76Propanoic acid8F76-OR51E2-Propanoic acid-Gs/β1/γ2
7.69Single8GH1Constrained Epinephrine8GH1-β2-Constrained Epinephrine
7.69Single8HCQEndothelin-18HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/β1/γ2
7.69Single8IODPG-9018IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/β1/γ2
7.69Single8J21Butyric acid8J21-FFA3-Butyric acid-Gi1/β1/γ2
7.69Single8J24Acetic acid8J24-FFA2-Acetic acid-Gi1/β1/γ2
7.69Single8J6QCompound 9n8J6Q-HCA2-β-Hydroxybutyrate-Compound 9n-Gi1/β1/γ2
7.69Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; Spermine8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; Spermine
7.69Single8ZPSPrRP208ZPS-PrRP-PrRP20-chim(NtGi1-Gs-CtGq)/β1/γ2
7.69Consensus5ht2_onOrthosteric Ligand5ht2b_on
7.69Consensus5ht2b_onOrthosteric Ligand7SRR-5-HT2B-LSD-chim(NtGi2L-Gs-CtGq)/β1/γ2
7.69Consensuseta_onOrthosteric Ligand8HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/β1/γ2
7.69Consensuseta_on_gpOrthosteric Ligand8HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/β1/γ2
7.69Consensusffa3_onOrthosteric Ligand8J21-FFA3-Butyric acid-Gi1/β1/γ2
7.69Consensusffa3_on_gpOrthosteric Ligand8J21-FFA3-Butyric acid-Gi1/β1/γ2
7.41Consensusnpy4_onOrthosteric Ligand7X9C-Y4-Pancreatic Hormone-Gi1/β1/γ2
7.41Consensusnpy4_on_gpOrthosteric Ligand7X9C-Y4-Pancreatic Hormone-Gi1/β1/γ2
7.14Single3PBLEticlopride3PBL-D3-Eticlopride
7.14Single6FK6PubChem 1324730336FK6-Rhodopsin-PubChem 132473033
7.14Single6HLLCP999946HLL-NK1-CP99994
7.14Single6PGSGeraniol6PGS-Rhodopsin-Geraniol-Gt(CT)
7.14Single6PH7Nerol6PH7-Rhodopsin-Nerol-Gt(CT)
7.14Single6QNOAll-trans-Retinal6QNO-Rhodopsin-All-trans-Retinal-Gi1/β1/γ1
7.14Single6TP4ACT-4622066TP4-OX1-ACT-462206
7.14Single6TQ4PubChem 160468446TQ4-OX1-PubChem 16046844-Na
7.14Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
7.14Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
7.14Single7E2YSerotonin7E2Y-5-HT1A-Serotonin-Gi1/β1/γ2
7.14Single7F53Alpha-MSH7F53-MC4-α-MSH-Gs/β1/γ2
7.14Single7SRQLSD7SRQ-5-HT2B-LSD
7.14Single7VUIJNJ-635330547VUI-GPR139-JNJ-63533054-GTP-chim(Gs-CtGq)/β1/γ2
7.14Single7XT9Serotonin7XT9-5-HT4-Serotonin-Gs/β1/γ2
7.14Single7XTASerotonin7XTA-5-HT4-Serotonin-Gi1/β1/γ2
7.14Single7XTBSerotonin7XTB-5-HT6-Serotonin-Gs/β1/γ2
7.14Single7YOONeuropeptide-Y7YOO-Y2-Neuropeptide-Y-Gi1/β1/γ2
7.14Single7YS6Serotonin7YS6-5-HT6-Serotonin-chim(NtGi1-Gs)/β1/γ2
7.14Single8A2PLUAA470708A2P-A2A-LUAA47070-Na
7.14Single8EF6Morphine8EF6-μ-Morphine-Gi1/β1/γ2
7.14Single8IKHQ2L8IKH-CB1-Q2L-Gi1/β1/γ1
7.14Single8J6PCompound 9n8J6P-HCA2-Niacin-Compound 9n-Gi1/β1/γ2
7.14Single8JHYCompound 9n8JHY-HCA2-Compound 9n-Gi1/β1/γ2
7.14Single8JIICompound 9n8JII-HCA2-Niacin-Compound 9n-Gi1/β1/γ2
7.14Single8RWHStilSwitch28RWH-A2A-StilSwitch2-Na
7.14Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; Spermine8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; Spermine
7.14Single8W8WAlpha-MSH8W8W-MC3-α-MSH-Ca-Gs/β1/γ2
7.14Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/β1/γ2
7.14Single8YH3N-methyladenosine8YH3-A3A-N-methyladenosine-Gi1/β1/γ2
7.14Single8YN4Histamine8YN4-H2-Histamine-chim(NtGi1L-Gs-CtGq)/β1/γ2
7.14Single8ZH8QRF-Amide8ZH8-QRFP-QRF-Amide-Gq/β1/γ1
7.14Single9C1PCa; Tryptophan; '6218; PO49C1P-CaS-Ca-Ca; Tryptophan; '6218; PO4
7.14Single9E7RGB889E7R-PAR2-GB88-chim(NtGi1L-Gs-CtGq)/β1/γ2
7.14Single9IXJHistamine9IXJ-H2-Histamine-Gs/β1/γ2
7.14Single9K26PrRP319K26-PrRP-PrRP31-Gi1/β1/γ2
7.14Single9L3ZLRH7-C29L3Z-CML1-LRH7-C2
7.14Consensus5ht4_onOrthosteric Ligand7XTA-5-HT4-Serotonin-Gi1/β1/γ2
7.14Consensus5ht4_on_gpOrthosteric Ligand7XTA-5-HT4-Serotonin-Gi1/β1/γ2
7.14Consensusadgrg_onOrthosteric Ligandadgrg2_on adgrg4_on
7.14Consensusadgrg_on_gpOrthosteric Ligandadgrg2_on_gp adgrg4_on_gp
7.14Consensusd3_offOrthosteric Ligand3PBL-D3-Eticlopride
7.14Consensusnpy2_onOrthosteric Ligand7YOO-Y2-Neuropeptide-Y-Gi1/β1/γ2
7.14Consensusnpy2_on_gpOrthosteric Ligand7YOO-Y2-Neuropeptide-Y-Gi1/β1/γ2
7.14Consensusp2y10_on_gpOrthosteric Ligand8KGG-P2Y10-LPS-chim(NtGi2-G13)/β1/γ2
6.90Single7VGXNeuropeptide-Y7VGX-Y1-Neuropeptide-Y-Gi1/β1/γ2
6.90Consensusgs_melanocortinOrthosteric Ligand7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2 7F54-MC4-Afamelanotide-Gs/β1/γ2 7F4D-MC1-α-MSH-chim(NtGi1-Gs)/β1/γ2 8INR-MC5-α-MSH-Ca-chim(NtGi1-Gs)/β1/γ2 7F53-MC4-α-MSH-Gs/β1/γ2 7F55-MC4-Bremelanotide-Gs/β1/γ2 8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1 8IOC-MC3-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2 8IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/β1/γ2 7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2 7F4I-MC1-SHU9119-chim(NtGi1-Gs)/β1/γ2 7F58-MC4-THIQ-Gs/β1/γ2
6.67Single2X72All-trans-Retinal2X72-Rhodopsin-All-trans-Retinal-Gt(CT)
6.67Single3PWHZM-2413853PWH-A2A-ZM-241385
6.67Single3VG9ZM-2413853VG9-A2A-ZM-241385-Antibody
6.67Single3VGAZM-2413853VGA-A2A-ZM-241385-Antibody
6.67Single4S0VSuvorexant4S0V-OX2-Suvorexant
6.67Single5K2DZM-2413855K2D-A2A-ZM-241385-Na
6.67Single5OLHVipadenant5OLH-A2A-Vipadenant-Na
6.67Single5OLOTozadenant5OLO-A2A-Tozadenant-Na
6.67Single5OLVLUAA410635OLV-A2A-LUAA41063-Na
6.67Single5WS3EMPA5WS3-OX2-EMPA
6.67Single6AKXA4R6AKX-CCR5-A4R
6.67Single6B73MP11046B73-κ-MP1104
6.67Single6D9HAdenosine6D9H-A1-Adenosine-Gi2/β1/γ2
6.67Single6DS0Ly2660976DS0-5-HT2B-Ly266097
6.67Single6FKBPubChem 1324730386FKB-Rhodopsin-PubChem 132473038
6.67Single6JZHZM-2413856JZH-A2A-ZM-241385-Na
6.67Single6NWEOctyl-Beta-D-Glucopyranoside6NWE-Rhodopsin-Octyl-β-D-Glucopyranoside-Gt(CT)
6.67Single6PS7ZM-2413856PS7-A2A-ZM-241385-Na
6.67Single6TODEMPA6TOD-OX1-EMPA-Na
6.67Single6TPJSuvorexant6TPJ-OX2-Suvorexant
6.67Single6TQ6PubChem 1457142836TQ6-OX1-PubChem 145714283
6.67Single6ZA8RTI-3a6ZA8-NTS1-RTI-3a
6.67Single7BR3Elagolix7BR3-GnRH1-Elagolix
6.67Single7DHRIsoprenaline7DHR-β2-Isoprenaline-Gs/β1/γ2
6.67Single7EJ0L-Norepinephrine7EJ0-α2a-L-Norepinephrine-Go/β1/γ2
6.67Single7F1ODopamine7F1O-D1-Dopamine-GDP; Mg-Gs/β1/γ2
6.67Single7F8ULintitript7F8U-CCKA-Lintitript
6.67Single7F8YDevazepide7F8Y-CCKA-Devazepide
6.67Single7LD4Adenosine7LD4-A1-Adenosine-Gi2/β1/γ2
6.67Single7LJDDopamine7LJD-D1-Dopamine-Mevidalen-Gs/β1/γ1
6.67Single7M3ECa; Ca; Tryptophan; NPS-21437M3E-CaS-Ca; Ca; Tryptophan; NPS-2143
6.67Single7M3ECa; Ca; Tryptophan; NPS-21437M3E-CaS-Ca; Ca; Tryptophan; NPS-2143
6.67Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
6.67Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
6.67Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
6.67Single7SRRLSD7SRR-5-HT2B-LSD-chim(NtGi2L-Gs-CtGq)/β1/γ2
6.67Single7SRSLSD7SRS-5-HT2B-LSD-Arrestin2
6.67Single7VUJJNJ-635330547VUJ-GPR139-JNJ-63533054-GDP-chim(Gs-CtGq)/β1/γ2
6.67Single7W0MPubChem 1227019087W0M-Apelin-PubChem 122701908-Gi1/β1/γ2
6.67Single7WV9ZCZ0117WV9-CB1-CP55940-ZCZ011-Gi2/β1/γ2
6.67Single7X2FDopamine7X2F-D1-Dopamine-Mevidalen-Gs/β1/γ2
6.67Single7X5H5-CT7X5H-5-HT5A-5-CT-Gi1/β1/γ2
6.67Single7XRRLemborexant7XRR-OX2-Lemborexant
6.67Single7XT8Serotonin7XT8-5-HT4-Serotonin-Gs/β1/γ2
6.67Single8DU3PubChem 1055260648DU3-A2A-PubChem 105526064
6.67Single8DWGML3828DWG-MRGPRX1-Proenkephalin-A-ML382-chim(NtGi2L-Gs-CtGq)/β1/γ2
6.67Single8EFOPZM218EFO-μ-PZM21-Gi1/β1/γ2
6.67Single8GGZConstrained Epinephrine8GGZ-β2-Constrained Epinephrine
6.67Single8GNGIstradefylline8GNG-A2A-Istradefylline
6.67Single8H8JLodoxamide8H8J-GPR35-Lodoxamide-Ca-chim(NtGi1L-G13)/β1/γ2
6.67Single8HDPAdenosine8HDP-A2B-Adenosine-Gs/β1/γ2
6.67Single8J20Valeric acid8J20-FFA3-Valeric acid-AR420626-Gi1/β1/γ2
6.67Single8RVWStilSwitch38RVW-A2A-StilSwitch3-Na
6.67Single8RW0Istradefylline8RW0-A2A-Istradefylline-Na
6.67Single8RW4AzoSwitch28RW4-A2A-AzoSwitch2-Na
6.67Single8RWEStilSwitch48RWE-A2A-StilSwitch4-Na
6.67Single8T3VDocosa-4,7,10,13,16,19-Hexaenoic acid8T3V-FFA1-Docosa-4,7,10,13,16,19-Hexaenoic acid-chim(NtGi2L-Gs-CtGq)/β1/γ2
6.67Single8TZQL-Dopamine8TZQ-D2-L-Dopamine-Go/β1/γ2
6.67Single8UNSConstrained Epinephrine8UNS-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
6.67Single8UNTConstrained Epinephrine8UNT-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
6.67Single8UNXConstrained Epinephrine8UNX-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
6.67Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
6.67Single8YUTAmthamine8YUT-H2-Amthamine-Gs/β1/γ2
6.67Single8YYWAlpha-ketoglutarate8YYW-Oxoglutarate-α-ketoglutarate-α-ketoglutarate-chim(Gi1-CtGq)/β1/γ2
6.67Single9AVLCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVL-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi3/β2/γ2
6.67Single9C1PCa; Tryptophan; '6218; PO49C1P-CaS-Ca-Ca; Tryptophan; '6218; PO4
6.67Single9C2FCa; Ca; Tryptophan; '54149; PO49C2F-CaS-Ca-Ca; Ca; Tryptophan; '54149; PO4
6.67Single9EBHAdenosine9EBH-A3A-Adenosine-Gi1/β1/γ2
6.67Single9EEAAdenosine9EEA-A2A-Adenosine-Gs/β1/γ2
6.67Single9FUPIstradefylline9FUP-A2A-Istradefylline-Na
6.67Single9H2XA1IR19H2X-A2A-A1IR1-Na
6.67Single9J5VCpY9J5V-LPA1-CpY-Gi1/β1/γ2
6.67Single9K6LSA09K6L-TAS2R16-SA0-Gi2/β1/γ2
6.67Single9KPESA09KPE-TAS2R16-SA0-Gi1/β1/γ2
6.67Single9LRBHistamine9LRB-H1-Histamine-Gs/β1/γ2
6.67Single9MQJIsoquinuclidine9MQJ-μ-Isoquinuclidine
6.67Consensus5ht1e_onOrthosteric Ligand7E33-5-HT1E-BRL-54443-Gi1/β1/γ2 8UGY-5-HT1E-Mianserin-Gi1/β1/γ1 8UH3-5-HT1E-Setiptiline-Gi1/β1/γ1
6.67Consensus5ht2_on_gpOrthosteric Ligand5ht2b_on_gp
6.67Consensus5ht2b_on_gpOrthosteric Ligand7SRR-5-HT2B-LSD-chim(NtGi2L-Gs-CtGq)/β1/γ2
6.67Consensus5ht_onOrthosteric Ligand5ht1_on 5ht2_on 5ht4_on 5ht5_on 5ht6_on 5ht7_on
6.67Consensusa1_onOrthosteric Ligand7LD4-A1-Adenosine-Gi2/β1/γ2
6.67Consensusa1_on_gpOrthosteric Ligand7LD4-A1-Adenosine-Gi2/β1/γ2
6.67Consensusalpha2_offOrthosteric Ligandalpha2c_off
6.67Consensusgi_npyOrthosteric Ligand8K6M-Y1-Neuropeptide-Y-Gi2/β1/γ1 7X9C-Y4-Pancreatic Hormone-Gi1/β1/γ2 7YOO-Y2-Neuropeptide-Y-Gi1/β1/γ2
6.67Consensusgnrh1_offOrthosteric Ligand7BR3-GnRH1-Elagolix
6.67Consensusgs_5htOrthosteric Ligand7XTC-5-HT7-5-CT-Gs/β1/γ2 7XTB-5-HT6-Serotonin-Gs/β1/γ2 8JLZ-5-HT6-ST1936-Gs/β1/γ2 7XT8-5-HT4-Serotonin-Gs/β1/γ2
6.67Consensusnpy_onOrthosteric Ligandnpy1_on npy2_on npy4_on
6.67Consensusnpy_on_gpOrthosteric Ligandnpy1_on_gp npy2_on_gp npy4_on_gp
6.67Consensusorexin_offOrthosteric Ligandox2_off ox1_off
6.67Consensusox1_offOrthosteric Ligand6TP6-OX1-Filorexant 6TP4-OX1-ACT-462206 6V9S-OX1-GTPL11403 6TOT-OX1-Lemborexant 6TP3-OX1-Nemorexant 6TQ6-OX1-PubChem 145714283 6TQ9-OX1-SB-408124 4ZJC-OX1-SB-674042 4ZJ8-OX1-Suvorexant 6TOD-OX1-EMPA-Na 6TOS-OX1-GSK1059865-Na 6TQ4-OX1-PubChem 16046844-Na
6.67Consensusox2_offOrthosteric Ligand5WQC-OX2-EMPA 6TPN-OX2-HTL6641 7XRR-OX2-Lemborexant 6TPJ-OX2-Suvorexant
6.45Consensusmelanocortin_onOrthosteric Ligandmc1_on mc4_on mc2_on mc3_on mc5_on
6.45Consensusmelanocortin_on_gpOrthosteric Ligandmc1_on_gp mc4_on_gp mc2_on_gp mc3_on_gp mc5_on_gp
6.25Single2YDOAdenosine2YDO-A2A-Adenosine
6.25Single3REYXAC3REY-A2A-XAC
6.25Single3RZECidoxepin3RZE-H1-Cidoxepin
6.25Single3UZC4-(3-amino-5-phenyl-1,2,4-triazin-6-yl)-2-chlorophenol3UZC-A2A-4-(3-amino-5-phenyl-1,2,4-triazin-6-yl)-2-chlorophenol
6.25Single4DKLBeta-Funaltrexamine4DKL-μ-β-Funaltrexamine
6.25Single4LDOL-Epinephrine4LDO-β2-L-Epinephrine
6.25Single4MBSMaraviroc4MBS-CCR5-Maraviroc
6.25Single4N6HNaltrindole4N6H-δ-Naltrindole-Na
6.25Single4ZJCSB-6740424ZJC-OX1-SB-674042
6.25Single5IU4ZM-2413855IU4-A2A-ZM-241385-Na
6.25Single5IU7Q274563465IU7-A2A-Q27456346-Na
6.25Single5IUBQ274563445IUB-A2A-Q27456344-Na
6.25Single5JTBZM-2413855JTB-A2A-ZM-241385
6.25Single5K2BZM-2413855K2B-A2A-ZM-241385-Na
6.25Single5K2CZM-2413855K2C-A2A-ZM-241385-Na
6.25Single5NLXZM-2413855NLX-A2A-ZM-241385-Na
6.25Single5NM4ZM-2413855NM4-A2A-ZM-241385-Na
6.25Single5TE3Octyl-Beta-D-Glucopyranoside5TE3-Rhodopsin-Octyl-β-D-Glucopyranoside
6.25Single5UVIZM-2413855UVI-A2A-ZM-241385
6.25Single6AQFZM-2413856AQF-A2A-ZM-241385
6.25Single6FK8PubChem 1324730356FK8-Rhodopsin-PubChem 132473035
6.25Single6FKAPubChem 1324730376FKA-Rhodopsin-PubChem 132473037
6.25Single6IQLL7458706IQL-D4-L745870
6.25Single6K41Dexmedetomidine6K41-α2b-Dexmedetomidine-Go/β1/γ2
6.25Single6MH8ZM-2413856MH8-A2A-ZM-241385
6.25Single6PELCitronellol6PEL-Rhodopsin-Citronellol-Gt(CT)
6.25Single6PS0S-Carazolol6PS0-β2-S-Carazolol
6.25Single6PS4ICI118-5516PS4-β2-ICI118-551
6.25Single6PS5S-Propranolol6PS5-β2-S-Propranolol
6.25Single6TOSGSK10598656TOS-OX1-GSK1059865-Na
6.25Single6TP3Nemorexant6TP3-OX1-Nemorexant
6.25Single6TPGEMPA6TPG-OX2-EMPA
6.25Single6TPKRetosiban6TPK-OT-Retosiban
6.25Single6TPNHTL66416TPN-OX2-HTL6641
6.25Single6V9SGTPL114036V9S-OX1-GTPL11403
6.25Single6VI4JDTic6VI4-κ-JDTic
6.25Single6WJCMuscarinic toxin 76WJC-M1-Atropine-Muscarinic toxin 7
6.25Single6ZDRHMS1413f126ZDR-A2A-HMS1413f12-Na
6.25Single6ZDVChromone 5d6ZDV-A2A-Chromone 5d-Na
6.25Single6ZINSR486926ZIN-NTS1-SR48692
6.25Single7AROLUF58337ARO-A2A-LUF5833-Na
6.25Single7BB6AVP7BB6-V2-AVP-Gs/β1/γ2
6.25Single7CKWFenoldopam7CKW-D1-Fenoldopam-Gs/β1/γ2
6.25Single7CKZDopamine7CKZ-D1-Dopamine-Mevidalen-Gs/β1/γ2
6.25Single7CMUPramipexole7CMU-D3-Pramipexole-Gi1/β1/γ2
6.25Single7CMVPD1289077CMV-D3-PD128907-Gi1/β1/γ2
6.25Single7E33BRL-544437E33-5-HT1E-BRL-54443-Gi1/β1/γ2
6.25Single7EJ8Brimonidine7EJ8-α2a-Brimonidine-Go/β1/γ2
6.25Single7EJADexmedetomidine7EJA-α2a-Dexmedetomidine-Go/β1/γ2
6.25Single7F0TDopamine7F0T-D1-Dopamine-Gs/β1/γ2
6.25Single7F1ZDopamine7F1Z-D1-Dopamine-GDP-Gs/β1/γ2
6.25Single7F24Dopamine7F24-D1-Dopamine-GDP-Gs/β1/γ2
6.25Single7RANPubChem 1645758477RAN-5-HT2A-PubChem 164575847-chim(NtGi2L-Gs-CtGq)/β1/γ2
6.25Single7SR8TAK-9257SR8-OX2-TAK-925-chim(NtGi1L-Gs-CtGq)/β1/γ2
6.25Single7WC9PubChem 1624213647WC9-5-HT2A-PubChem 162421364
6.25Single7XOVSR1461317XOV-CCKA-SR146131-Gs/β1/γ2
6.25Single8GEDConstrained Epinephrine8GED-β2-Constrained Epinephrine-Gs/β1/γ2
6.25Single8GG5Constrained Epinephrine8GG5-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
6.25Single8GG7Constrained Epinephrine8GG7-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
6.25Single8GGLConstrained Epinephrine8GGL-β2-Constrained Epinephrine
6.25Single8GGMConstrained Epinephrine8GGM-β2-Constrained Epinephrine
6.25Single8GGPConstrained Epinephrine8GGP-β2-Constrained Epinephrine
6.25Single8GGQConstrained Epinephrine8GGQ-β2-Constrained Epinephrine
6.25Single8GGXConstrained Epinephrine8GGX-β2-Constrained Epinephrine
6.25Single8H4LDoconexent8H4L-FFA4-Doconexent-chim(NtGi1-Gs-CtGq)/β1/γ2
6.25Single8IYXYL-3658IYX-GPR34-YL-365
6.25Single8K4SDCA-3P8K4S-MRGPRX4-DCA-3P-chim(NtGi1L-Gs-CtGq)/β1/γ2
6.25Single8K9KDamgo8K9K-μ-Damgo-Gi3/β1/γ1
6.25Single8K9LDamgo8K9L-μ-Damgo-BMS-986122-Gi3/β1/γ1
6.25Single8RLNLUF58348RLN-A2A-LUF5834
6.25Single8RQQZM-2413858RQQ-A2A-ZM-241385-Na
6.25Single8RWCStilSwitch28RWC-A2A-StilSwitch2-Na
6.25Single8RWDStilSwitch38RWD-A2A-StilSwitch3-Na
6.25Single8RWIStilSwitch28RWI-A2A-StilSwitch2-Na
6.25Single8THLEpinephrine8THL-Alpha1A-Epinephrine-chim(NtGi2L-Gs-CtGq)/β1/γ2
6.25Single8U02L-Dopamine8U02-D2-L-Dopamine-Go/β1/γ2
6.25Single8UNLConstrained Epinephrine8UNL-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
6.25Single8UNMConstrained Epinephrine8UNM-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
6.25Single8UNOConstrained Epinephrine8UNO-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
6.25Single8UNWConstrained Epinephrine8UNW-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
6.25Single8UO0Constrained Epinephrine8UO0-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
6.25Single8UO1Constrained Epinephrine8UO1-β2-Constrained Epinephrine-GTP; Mg-Gs/β1/γ2
6.25Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
6.25Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/β1/γ2
6.25Single8Y01Retinal8Y01-Opsin1MW-Retinal-Gi1/β1/γ2
6.25Single8Y45ADL58598Y45-δ-ADL5859-Gi2/β1/γ2
6.25Single8Y53MK50468Y53-BB3-MK5046-chim(NtGi1-Gs-CtGq)/β1/γ2
6.25Single8YH2Adenosine8YH2-A3A-Adenosine-Gi1/β1/γ2
6.25Single8YN3Histamine8YN3-H2-Histamine-Gs/β1/γ2
6.25Single9ARXSerotonin9ARX-5-HT2A-Serotonin
6.25Single9AS3LSD9AS3-5-HT2A-LSD
6.25Single9AS4LSD9AS4-5-HT2A-LSD-chim(NtGi1-Gs-CtGq)/β1/γ2
6.25Single9AS5Mescaline9AS5-5-HT2A-Mescaline
6.25Single9AS6Mescaline9AS6-5-HT2A-Mescaline-chim(NtGi1-Gs-CtGq)/β1/γ2
6.25Single9ASBCa; Ca; Cyclomethyltryptophan; 9IG; PO49ASB-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
6.25Single9ASBCa; Ca; Cyclomethyltryptophan; 9IG; PO49ASB-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
6.25Single9AVGCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVG-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs)/β1/γ2
6.25Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
6.25Single9EPQ11,20-Ethanoretinal9EPQ-Rhodopsin-11,20-Ethanoretinal-chim(Gi1-CtGq)/β1/γ2
6.25Single9IXXLTD49IXX-CysLT2-LTD4-chim(NtGi1-Gs-CtGq)/β1/γ2
6.25Single9K1DButanoic acid9K1D-FFA2-Butanoic acid-Gi1/β1/γ2
6.25Single9KPDSA09KPD-TAS2R16-SA0-chim(Gs-CtGt3)/β1/γ2
6.25Single9LRDHistamine9LRD-H1-Histamine-Gi1/β1/γ2
6.25Single9M2FNeuropeptide FF9M2F-NPFF1-Neuropeptide FF-Gi1/β1/γ2
6.25Single9MQIIsoquinuclidine9MQI-μ-Isoquinuclidine
6.25Consensus5ht_on_gpOrthosteric Ligand5ht1_on_gp 5ht2_on_gp 5ht4_on_gp 5ht5_on_gp 5ht6_on_gp 5ht7_on_gp
6.25Consensusa2_offOrthosteric Liganda2a_off
6.25Consensusa2a_offOrthosteric Ligand3RFM-A2A-Caffeine 8C9W-A2A-Etrumadenant 3UZA-A2A-GTPL9236 8GNG-A2A-Istradefylline 8CU6-A2A-LJ-4517 7PX4-A2A-PSB-2113 7PYR-A2A-PSB-2115 8DU3-A2A-PubChem 105526064 8JWY-A2A-2-118 8PWN-A2A-Theophylline 5IU4-A2A-ZM-241385-Na 5OLZ-A2A-PubChem 135566609-Na 6GT3-A2A-Imaradenant-Na 5OLV-A2A-LUAA41063-Na 5N2R-A2A-PSB-36-Na 5IU7-A2A-Q27456346-Na 5OLH-A2A-Vipadenant-Na 5OLO-A2A-Tozadenant-Na 6ZDR-A2A-HMS1413f12-Na 8GNE-A2A-KW-6356-Na 8JWZ-A2A-AB928-Na 5IU8-A2A-Q27456347-Na 5IUB-A2A-Q27456344-Na 6ZDV-A2A-Chromone 5d-Na 5IUA-A2A-Q27456348-Na 8A2P-A2A-LUAA47070-Na
6.25Consensusadenosine_onOrthosteric Liganda1_on a2_on a3_on
6.25Consensusalpha1_onOrthosteric Ligandalpha1a_on
6.25Consensusalpha1_on_gpOrthosteric Ligandalpha1a_on_gp
6.25Consensusalpha1a_onOrthosteric Ligand7EJ0-α2a-L-Norepinephrine-Go/β1/γ2 7EJ8-α2a-Brimonidine-Go/β1/γ2 7EJA-α2a-Dexmedetomidine-Go/β1/γ2 7EJK-α2a-Oxymetazoline-Go/β1/γ2 7W6P-α2a-N-pyridin-4-ylisoquinolin-4-amine-Go/β1/γ2 7W7E-α2a-PubChem 164946676-Go/β1/γ2
6.25Consensusalpha1a_on_gpOrthosteric Ligand7EJ0-α2a-L-Norepinephrine-Go/β1/γ2 7EJ8-α2a-Brimonidine-Go/β1/γ2 7EJA-α2a-Dexmedetomidine-Go/β1/γ2 7EJK-α2a-Oxymetazoline-Go/β1/γ2 7W6P-α2a-N-pyridin-4-ylisoquinolin-4-amine-Go/β1/γ2 7W7E-α2a-PubChem 164946676-Go/β1/γ2
6.25Consensusd3_onOrthosteric Ligand7CMV-D3-PD128907-Gi1/β1/γ2 8IRT-D3-Rotigotine-Gi1/β1/γ2 7CMU-D3-Pramipexole-Gi1/β1/γ2
6.25Consensusd3_on_gpOrthosteric Ligand7CMV-D3-PD128907-Gi1/β1/γ2 8IRT-D3-Rotigotine-Gi1/β1/γ2 7CMU-D3-Pramipexole-Gi1/β1/γ2
6.25Consensusghrelin_offOrthosteric Ligand6KO5-Ghrelin-PubChem 57400002 7F83-Ghrelin-PF-05190457
6.25Consensusgi_adenosineOrthosteric Ligand7LD4-A1-Adenosine-Gi2/β1/γ2 8X17-A3A-Namodenoson-Gi1/β1/γ2 8X16-A3A-Piclidenoson-Gi1/β1/γ2
6.25Consensusgrh_offOrthosteric Ligandgnrh1_off
6.25Consensusgs_peptideOrthosteric Ligandgs_cck gs_melanocortin gs_vasop-oxy
6.25Consensusnop_offOrthosteric Ligand4EA3-NOP-PubChem 10296561 5DHG-NOP-C-35 5DHH-NOP-SB-612111
6.25Consensusnucleotide_offOrthosteric Ligandadenosine_off p2y_off
6.25Consensusot_offOrthosteric Ligand6TPK-OT-Retosiban
6.25Consensusvasop-oxy_offOrthosteric Ligandot_off
6.06Single7X9ANeuropeptide-Y7X9A-Y1-Neuropeptide-Y-Gi1/β1/γ2
5.88Single2VT4Cyanopindolol2VT4-β1-Cyanopindolol
5.88Single2Y02Carmoterol2Y02-β1-Carmoterol
5.88Single2YCYCyanopindolol2YCY-β1-Cyanopindolol
5.88Single3EMLZM-2413853EML-A2A-ZM-241385
5.88Single3NY8ICI118-5513NY8-β2-ICI118-551
5.88Single3NYAS-Alprenolol3NYA-β2-S-Alprenolol
5.88Single3ZPQ4-(piperazin-1- yl)-1H-indole3ZPQ-β1-4-(piperazin-1- yl)-1H-indole-Na
5.88Single3ZPR4-methyl-2-(piperazin-1-yl)3ZPR-β1-4-methyl-2-(piperazin-1-yl)-Na
5.88Single4EA3PubChem 102965614EA3-NOP-PubChem 10296561
5.88Single4EIYZM-2413854EIY-A2A-ZM-241385-Na
5.88Single4EJ4Naltrindole4EJ4-δ-Naltrindole
5.88Single4GBRS-Carazolol4GBR-β2-S-Carazolol
5.88Single4J4QOctyl Beta-D-Glucopyranoside4J4Q-Rhodopsin-Octyl β-D-Glucopyranoside-Gt(CT)
5.88Single4QIMANTA XV4QIM-SMO-ANTA XV
5.88Single4X1HNonyl-Beta-D-Glucopyranoside4X1H-Rhodopsin-Nonyl-β-D-Glucopyranoside-Gt(CT)
5.88Single5DHGC-355DHG-NOP-C-35
5.88Single5DHHSB-6121115DHH-NOP-SB-612111
5.88Single5IU8Q274563475IU8-A2A-Q27456347-Na
5.88Single5K2AZM-2413855K2A-A2A-ZM-241385-Na
5.88Single5OLGZM-2413855OLG-A2A-ZM-241385-Na
5.88Single5OLZPubChem 1355666095OLZ-A2A-PubChem 135566609-Na
5.88Single5OM1PubChem 1355666095OM1-A2A-PubChem 135566609-Na
5.88Single5UENDU1725UEN-A1-DU172
5.88Single5UIGCmpd-15UIG-A2A-Cmpd-1
5.88Single5VRAZM-2413855VRA-A2A-ZM-241385-Na
5.88Single6FK7PubChem 1324730346FK7-Rhodopsin-PubChem 132473034
5.88Single6FKCPubChem 1324730396FKC-Rhodopsin-PubChem 132473039
5.88Single6FKDPubChem 1373491836FKD-Rhodopsin-PubChem 137349183
5.88Single6K42Dexmedetomidine6K42-α2b-Dexmedetomidine-Gi1/β1/γ2
5.88Single6LPJZM-2413856LPJ-A2A-ZM-241385-Na
5.88Single6LPKZM-2413856LPK-A2A-ZM-241385-Na
5.88Single6PRZS-Alprenolol6PRZ-β2-S-Alprenolol
5.88Single6PS1Timolol6PS1-β2-Timolol
5.88Single6PS2S-Alprenolol6PS2-β2-S-Alprenolol
5.88Single6S0LZM-2413856S0L-A2A-ZM-241385
5.88Single6TOTLemborexant6TOT-OX1-Lemborexant
5.88Single6XBM5LWE6XBM-SMO-5LWE-Gi1/β1/γ2
5.88Single6Z4VNTS8-136Z4V-NTS1-NTS8-13
5.88Single7BTSL-Epinephrine7BTS-β1-L-Epinephrine
5.88Single7BU6L-Norepinephrine7BU6-β1-L-Norepinephrine
5.88Single7BU7BI1671077BU7-β1-BI167107
5.88Single7CRHSKF839597CRH-D1-SKF83959-Gs/β1/γ2
5.88Single7DB6Ramelteon7DB6-MT1-Ramelteon-Gi1/β1/γ2
5.88Single7E32Serotonin7E32-5-HT1D-Serotonin-Gi1/β1/γ2
5.88Single7FIHOrg435537FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/β1/γ2
5.88Single7JOZVFP7JOZ-D1-VFP-Gs/β1/γ2
5.88Single7JVQApomorphine7JVQ-D1-Apomorphine-Gs/β1/γ2
5.88Single7LJCSKF-812977LJC-D1-SKF-81297-Mevidalen-Gs/β1/γ2
5.88Single7M3JNPS-2143; PO47M3J-CaS-NPS-2143; PO4
5.88Single7NA8PubChem 1780247NA8-Ghrelin-PubChem 178024-Gi1/β1/γ2
5.88Single7PYRPSB-21157PYR-A2A-PSB-2115
5.88Single7S0GIsoprenaline7S0G-β1-Isoprenaline-chim(Gi1-CtGs)/β1/γ2
5.88Single7SCGFH2107SCG-μ-FH210-Gi1/β1/γ2
5.88Single7SQOTAK-9257SQO-OX2-TAK-925-Gi1/β1/γ2
5.88Single7T2GMitragynine Pseudoindoxyl7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2
5.88Single7UL4Alvimopan7UL4-μ-Alvimopan
5.88Single7UM55-CT7UM5-5-HT5A-5-CT-chim(NtGi1-Go)/β1/γ2
5.88Single7UM6Lisuride7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/β1/γ2
5.88Single7VIES1P7VIE-S1P1-S1P-Gi1/β1/γ2
5.88Single7X2CFenoldopam7X2C-D1-Fenoldopam-Fenoldopam-Gs/β1/γ2
5.88Single7XTC5-CT7XTC-5-HT7-5-CT-Gs/β1/γ2
5.88Single7YU4ONO-07405567YU4-LPA1-ONO-0740556
5.88Single8CICEtrumadenant8CIC-A2A-Etrumadenant-Na
5.88Single8CU6LJ-45178CU6-A2A-LJ-4517
5.88Single8CU7LJ-45178CU7-A2A-LJ-4517-Na
5.88Single8DZSGR89,6968DZS-κ-GR89,696-chim(NtGi2-Gz)/β1/γ2
5.88Single8EFQDamgo8EFQ-μ-Damgo-Gi1/β1/γ2
5.88Single8EJKTAK-8758EJK-FFA1-TAK-875-chim(NtGi1L-Gs-CtGq)/β1/γ2
5.88Single8GE3Constrained Epinephrine8GE3-β2-Constrained Epinephrine-Gs/β1/γ2
5.88Single8GECConstrained Epinephrine8GEC-β2-Constrained Epinephrine-Gs/β1/γ2
5.88Single8GEEConstrained Epinephrine8GEE-β2-Constrained Epinephrine-Gs/β1/γ2
5.88Single8GEHConstrained Epinephrine8GEH-β2-Constrained Epinephrine-Gs/β1/γ2
5.88Single8GFVConstrained Epinephrine8GFV-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
5.88Single8GFWConstrained Epinephrine8GFW-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
5.88Single8GFXConstrained Epinephrine8GFX-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
5.88Single8GFZConstrained Epinephrine8GFZ-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
5.88Single8GG0Constrained Epinephrine8GG0-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
5.88Single8GG1Constrained Epinephrine8GG1-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
5.88Single8GG3Constrained Epinephrine8GG3-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
5.88Single8GG4Constrained Epinephrine8GG4-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
5.88Single8GG6Constrained Epinephrine8GG6-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
5.88Single8GG9Constrained Epinephrine8GG9-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
5.88Single8GGIConstrained Epinephrine8GGI-β2-Constrained Epinephrine
5.88Single8GGJConstrained Epinephrine8GGJ-β2-Constrained Epinephrine
5.88Single8GGKConstrained Epinephrine8GGK-β2-Constrained Epinephrine
5.88Single8GGNConstrained Epinephrine8GGN-β2-Constrained Epinephrine
5.88Single8GGOConstrained Epinephrine8GGO-β2-Constrained Epinephrine
5.88Single8GGUConstrained Epinephrine8GGU-β2-Constrained Epinephrine
5.88Single8IRTRotigotine8IRT-D3-Rotigotine-Gi1/β1/γ2
5.88Single8JD0NAM5638JD0-mGlu2; mGlu3-Glutamate-NAM563
5.88Single8JJOAlprenolol8JJO-β2-Alprenolol
5.88Single8JLZST19368JLZ-5-HT6-ST1936-Gs/β1/γ2
5.88Single8JT8(R)-IHCH-71798JT8-5-HT2A-(R)-IHCH-7179
5.88Single8KEXDCA-3P8KEX-MRGPRX4-DCA-3P
5.88Single8RW7StilSwitch18RW7-A2A-StilSwitch1-Na
5.88Single8RWXStilSwitch38RWX-A2A-StilSwitch3-Na
5.88Single8UGYMianserin8UGY-5-HT1E-Mianserin-Gi1/β1/γ1
5.88Single8UH3Setiptiline8UH3-5-HT1E-Setiptiline-Gi1/β1/γ1
5.88Single8UNQConstrained Epinephrine8UNQ-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
5.88Single8UNRConstrained Epinephrine8UNR-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
5.88Single8UNUConstrained Epinephrine8UNU-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
5.88Single8UNVConstrained Epinephrine8UNV-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
5.88Single8UNYConstrained Epinephrine8UNY-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
5.88Single8UNZConstrained Epinephrine8UNZ-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
5.88Single8UO2Constrained Epinephrine8UO2-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
5.88Single8VVGGB188VVG-κ-GB18-Gi1/β1/γ2
5.88Single8X17Namodenoson8X17-A3A-Namodenoson-Gi1/β1/γ2
5.88Single8X63Mepyramine8X63-H1-Mepyramine
5.88Single8X64Desloratadine8X64-H1-Desloratadine
5.88Single8X9TAP5038X9T-ADGRD1-AP503-chim(NtGi1-Gs)/β1/γ2
5.88Single8XVKAmbrisentan8XVK-ETA-Ambrisentan
5.88Single8Y73MPAM-158Y73-μ-Peptide-MPAM-15-Gi1/β1/γ2
5.88Single8YH5Riboprine8YH5-A3A-Riboprine-Gi1/β1/γ2
5.88Single8ZQEGPR15L(C11)8ZQE-GPR15-GPR15L(C11)-Gi1/β1/γ1
5.88Single8ZYYNeurotensin peptide 8-138ZYY-NTS1-Neurotensin peptide 8-13-SBI-553-Arrestin2
5.88Single9AVGCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVG-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs)/β1/γ2
5.88Single9CBMDexmedetomidine9CBM-α2a-Dexmedetomidine-Gi1/β1/γ2
5.88Single9CHXS-Carazolol9CHX-β2-S-Carazolol
5.88Single9D61JDTic9D61-κ-JDTic-Gi1/β1/γ2
5.88Single9H37A1IR09H37-A2A-A1IR0-Na
5.88Single9PLNN-(5-methylnaphthalen-1-yl)pyridin-4-amine9PLN-α2a-N-(5-methylnaphthalen-1-yl)pyridin-4-amine
5.88Single9PLON-(5-methylnaphthalen-1-yl)pyridin-4-amine9PLO-α2a-N-(5-methylnaphthalen-1-yl)pyridin-4-amine-Go/β1/γ2
5.88Single9PQD(6m)-1-methyl-6-(1,2,5,6-tetrahydropyridin-3-yl)-1h-indole9PQD-α2a-(6m)-1-methyl-6-(1,2,5,6-tetrahydropyridin-3-yl)-1h-indole
5.88Consensus5ht1d_onOrthosteric Ligand7E32-5-HT1D-Serotonin-Gi1/β1/γ2
5.88Consensus5ht1d_on_gpOrthosteric Ligand7E32-5-HT1D-Serotonin-Gi1/β1/γ2
5.88Consensus5ht5_onOrthosteric Ligand5ht5a_on
5.88Consensus5ht5a_onOrthosteric Ligand7X5H-5-HT5A-5-CT-Gi1/β1/γ2 7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/β1/γ2 7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/β1/γ2
5.88Consensus5ht6_onOrthosteric Ligand7XTB-5-HT6-Serotonin-Gs/β1/γ2 8JLZ-5-HT6-ST1936-Gs/β1/γ2
5.88Consensus5ht6_on_gpOrthosteric Ligand7XTB-5-HT6-Serotonin-Gs/β1/γ2 8JLZ-5-HT6-ST1936-Gs/β1/γ2
5.88Consensus5ht7_onOrthosteric Ligand7XTC-5-HT7-5-CT-Gs/β1/γ2
5.88Consensus5ht7_on_gpOrthosteric Ligand7XTC-5-HT7-5-CT-Gs/β1/γ2
5.88Consensusa3_onOrthosteric Liganda3a_on
5.88Consensusadenosine_on_gpOrthosteric Liganda1_on_gp a2_on_gp a3_on_gp
5.88Consensusadrenergic_onOrthosteric Ligandalpha_on beta_on
5.88Consensusalpha2_onOrthosteric Ligandalpha2b_on
5.88Consensusalpha2_on_gpOrthosteric Ligandalpha2b_on_gp
5.88Consensusalpha2b_onOrthosteric Ligand6K42-α2b-Dexmedetomidine-Gi1/β1/γ2
5.88Consensusalpha2b_on_gpOrthosteric Ligand6K42-α2b-Dexmedetomidine-Gi1/β1/γ2
5.88Consensusalpha_onOrthosteric Ligandalpha1_on alpha2_on
5.88Consensuscck_offOrthosteric Ligandccka_off
5.88Consensusccka_offOrthosteric Ligand7F8Y-CCKA-Devazepide 7F8U-CCKA-Lintitript
5.88Consensusdop_offOrthosteric Ligand4EJ4-δ-Naltrindole
5.88Consensusdopamine_offOrthosteric Ligandd2_off d3_off
5.88Consensusdopamine_onOrthosteric Ligandd2_on d1_on d3_on d4_on d5_on
5.88Consensusdopamine_on_gpOrthosteric Ligandd2_on_gp d1_on_gp d3_on_gp d4_on_gp d5_on_gp
5.88Consensusgi_orexinOrthosteric Ligand7SQO-OX2-TAK-925-Gi1/β1/γ2
5.88Consensushistamine_offOrthosteric Ligandh1_off
5.88Consensuslipid_offOrthosteric Ligandcannabinoid_off paf_off lpl_off prostanoid_off leukotriene_off
5.88Consensusnucleotide_offonOrthosteric Ligandnucleotide_off nucleotide_on
5.88Consensusnucleotide_offon_gpOrthosteric Ligandnucleotide_on_gp nucleotide_off
5.71Consensusmc2_onOrthosteric Ligand8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1
5.71Consensusmc2_on_gpOrthosteric Ligand8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1
5.56Single2RH1S-Carazolol2RH1-β2-S-Carazolol
5.56Single2YCWS-Carazolol2YCW-β1-S-Carazolol
5.56Single4PHUFasiglifam4PHU-FFA1-Fasiglifam
5.56Single4RWDDIPP-NH24RWD-δ-DIPP-NH2-Na
5.56Single4ZJ8Suvorexant4ZJ8-OX1-Suvorexant
5.56Single5C1MBU725C1M-μ-BU72
5.56Single5D6LS-Carazolol5D6L-β2-S-Carazolol
5.56Single5IUAQ274563485IUA-A2A-Q27456348-Na
5.56Single5JQHS-Carazolol5JQH-β2-S-Carazolol
5.56Single5N2RPSB-365N2R-A2A-PSB-36-Na
5.56Single5N2SPSB365N2S-A1-PSB36
5.56Single5NM2ZM-2413855NM2-A2A-ZM-241385-Na
5.56Single5OM4PubChem 1355666095OM4-A2A-PubChem 135566609-Na
5.56Single5TVNLSD5TVN-5-HT2B-LSD
5.56Single5WQCEMPA5WQC-OX2-EMPA
5.56Single5X7DS-Carazolol5X7D-β2-S-Carazolol-Cmpd-15
5.56Single5XPRBosentan5XPR-ETB-Bosentan
5.56Single6E67BI1671076E67-β2-BI167107-Gs(CT)
5.56Single6GDGNECA6GDG-A2A-NECA-Gs/β1/γ1
5.56Single6KUWPubChem 572132346KUW-α2c-PubChem 57213234
5.56Single6LPLZM-2413856LPL-A2A-ZM-241385-Na
5.56Single6PS3S-Carvedilol6PS3-β2-S-Carvedilol
5.56Single6PS6Timolol6PS6-β2-Timolol
5.56Single6S0QZM-2413856S0Q-A2A-ZM-241385
5.56Single6TO7Suvorexant6TO7-OX1-Suvorexant-Na
5.56Single6TP6Filorexant6TP6-OX1-Filorexant
5.56Single6WQAZM-2413856WQA-A2A-ZM-241385-Na
5.56Single6XBKCholesterol6XBK-SMO-Cholesterol-Gi1/β1/γ2
5.56Single6Z4SSR486926Z4S-NTS1-SR48692
5.56Single7BVQS-Carazolol7BVQ-β1-S-Carazolol
5.56Single7C61Ergotamine7C61-5-HT1B-Ergotamine
5.56Single7CFNINT-7777CFN-GPBA-INT-777-Gs/β1/γ2
5.56Single7CKXA776367CKX-D1-A77636-Gs/β1/γ2
5.56Single7EPFNAM5977EPF-mGlu2; mGlu2-NAM597
5.56Single7LD3Adenosine7LD3-A1-Adenosine-MIPS521-Gi2/β1/γ2
5.56Single7M3JNPS-2143; PO47M3J-CaS-NPS-2143; PO4
5.56Single7RM5ZM-2413857RM5-A2A-ZM-241385-Na
5.56Single7S0FIsoprenaline7S0F-β1-Isoprenaline-Gi1/β1/γ2
5.56Single7SBFPZM217SBF-μ-PZM21-Gi1/β1/γ2
5.56Single7SINNPS-21437SIN-CaS-NPS-2143
5.56Single7SINNPS-21437SIN-CaS-NPS-2143
5.56Single7VUHJNJ-635330547VUH-GPR139-JNJ-63533054-chim(Gs-CtGq)/β1/γ2
5.56Single7W41PD1762527W41-BB2-PD176252
5.56Single7WC6LSD7WC6-5-HT2A-LSD
5.56Single7WIGL-054,2647WIG-SST2-L-054,264-Gi1/β1/γ2
5.56Single7X1TTaltirelin7X1T-TRH-Taltirelin-chim(NtGi2L-Gs-CtGq)/β1/γ2
5.56Single7XK9Constrained Isoproterenol7XK9-β2-Constrained Isoproterenol-Na
5.56Single7XKAConstrained Epinephrine7XKA-β2-Constrained Epinephrine
5.56Single7Y26Octreotide7Y26-SST2-Octreotide-chim(NtGi2L-Gs-CtGq)/β1/γ2
5.56Single7YU3ONO-07405567YU3-LPA1-ONO-0740556-Gi1/β1/γ2
5.56Single7YU6ONO-07405567YU6-LPA1-ONO-0740556-Gi1/β1/γ2
5.56Single8C9WEtrumadenant8C9W-A2A-Etrumadenant
5.56Single8DZQmomSalB8DZQ-κ-momSalB-Go/β1/γ2
5.56Single8DZRGR89,6968DZR-κ-GR89,696-chim(NtGi2-Gt3)/β1/γ2
5.56Single8EJCTAK-8758EJC-FFA1-TAK-875-chim(NtGi1L-Gs-CtGq)/β1/γ2
5.56Single8FYNZM-2413858FYN-A2A-ZM-241385-Na
5.56Single8GDZConstrained Epinephrine8GDZ-β2-Constrained Epinephrine-Gs/β1/γ2
5.56Single8GEBConstrained Epinephrine8GEB-β2-Constrained Epinephrine-Gs/β1/γ2
5.56Single8GEGConstrained Epinephrine8GEG-β2-Constrained Epinephrine-Gs/β1/γ2
5.56Single8GFYConstrained Epinephrine8GFY-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
5.56Single8GG2Constrained Epinephrine8GG2-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
5.56Single8GGBConstrained Epinephrine8GGB-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
5.56Single8GNEKW-63568GNE-A2A-KW-6356-Na
5.56Single8ID4Linoleic acid8ID4-FFA4-Linoleic acid-Gi1/β1/γ2
5.56Single8K8JFenofibrate8K8J-CB1-Fenofibrate-chim(Gs-CtGq)/β1/γ2
5.56Single8KFXLMD-0098KFX-CCR8-LMD-009-Gi1/β1/γ2
5.56Single8QOTNanobody-E8QOT-μ-Nanobody-E
5.56Single8S4DCMF-0198S4D-Apelin-CMF-019
5.56Single8SZGCa; Ca; Tryptophan; Cinacalcet; PO4; Spermine8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; Spermine-chim(NtGi1-Gq)/β1/γ2
5.56Single8TF5Oleic acid8TF5-GPR6-Oleic acid
5.56Single8UNNConstrained Epinephrine8UNN-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
5.56Single8UNPConstrained Epinephrine8UNP-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
5.56Single8WGBVU01550418WGB-mGlu4; mGlu2-Glutammate-VU0155041-Gi3/β1/γ2
5.56Single8X0BVU04244658X0B-mGlu5; mGlu5-Quisqualate-VU0424465
5.56Single8X0DVU04244658X0D-mGlu5; mGlu5-Quisqualate-VU0424465
5.56Single8X0DVU04244658X0D-mGlu5; mGlu5-Quisqualate-VU0424465
5.56Single8YH0NECA8YH0-A3A-NECA-Gi1/β1/γ2
5.56Single9ARYSerotonin9ARY-5-HT2A-Serotonin-chim(NtGi1-Gs-CtGq)/β1/γ2
5.56Single9AVLCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVL-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi3/β2/γ2
5.56Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
5.56Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/β1/γ2
5.56Single9EE8Adenosine9EE8-A2A-Adenosine-Gs/β1/γ2
5.56Single9EHSLUF76029EHS-A3A-LUF7602
5.56Single9HAPTolvaptan9HAP-V2-Tolvaptan
5.56Single9HC04YI9HC0-mGlu5-4YI
5.56Single9I52A1IZU9I52-D1-A1IZU-Gs/β1/γ2
5.56Single9K07DSO-5a9K07-BB3-DSO-5a-chim(NtGi2L-Gs-CtGq)/β1/γ2
5.56Single9KPFSA09KPF-TAS2R16-SA0-Gi1/β1/γ2
5.56Single9MQKIsoquinuclidine9MQK-κ-Isoquinuclidine
5.56Consensus5ht1_onOrthosteric Ligand5ht1a_on 5ht1d_on 5ht1e_on 5ht1f_on
5.56Consensus5ht1_on_gpOrthosteric Ligand5ht1a_on_gp 5ht1d_on_gp 5ht1e_on_gp 5ht1f_on_gp
5.56Consensus5ht1e_on_gpOrthosteric Ligand7E33-5-HT1E-BRL-54443-Gi1/β1/γ2 8UGY-5-HT1E-Mianserin-Gi1/β1/γ1 8UH3-5-HT1E-Setiptiline-Gi1/β1/γ1
5.56Consensus5ht5_on_gpOrthosteric Ligand5ht5a_on_gp
5.56Consensus5ht5a_on_gpOrthosteric Ligand7X5H-5-HT5A-5-CT-Gi1/β1/γ2 7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/β1/γ2 7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/β1/γ2
5.56Consensusa1_offOrthosteric Ligand5UEN-A1-DU172 5N2S-A1-PSB36
5.56Consensusa3_on_gpOrthosteric Liganda3a_on_gp
5.56Consensusa3a_onOrthosteric Ligand8X17-A3A-Namodenoson-Gi1/β1/γ2 8X16-A3A-Piclidenoson-Gi1/β1/γ2
5.56Consensusa3a_on_gpOrthosteric Ligand8X17-A3A-Namodenoson-Gi1/β1/γ2 8X16-A3A-Piclidenoson-Gi1/β1/γ2
5.56Consensusadenosine_offOrthosteric Liganda1_off a2_off
5.56Consensusadgrg2_onOrthosteric Ligand7WUI-ADGRG2-IP15-chim(NtGi1-Gs)/β1/γ2 7WUQ-ADGRG2-Gs/β1/γ2 7XKF-ADGRG2-β-Hydroxyandrosterone-Gs/β1/γ2
5.56Consensusadgrg2_on_gpOrthosteric Ligand7WUI-ADGRG2-IP15-chim(NtGi1-Gs)/β1/γ2 7WUQ-ADGRG2-Gs/β1/γ2 7XKF-ADGRG2-β-Hydroxyandrosterone-Gs/β1/γ2
5.56Consensusadrenergic_offOrthosteric Ligandalpha_off beta_off
5.56Consensusadrenergic_on_gpOrthosteric Ligandalpha_on_gp beta_on_gp
5.56Consensusalpha2c_offOrthosteric Ligand6KUW-α2c-PubChem 57213234
5.56Consensusalpha_offOrthosteric Ligandalpha1_off alpha2_off
5.56Consensusalpha_on_gpOrthosteric Ligandalpha1_on_gp alpha2_on_gp
5.56Consensusamine_offOrthosteric Ligand5ht_off adrenergic_off dopamine_off histamine_off muscarinic_off
5.56Consensusamine_offonOrthosteric Ligandamine_off amine_on
5.56Consensusamine_offon_gpOrthosteric Ligandamine_on_gp amine_off
5.56Consensusamine_onOrthosteric Ligand5ht_on adrenergic_on dopamine_on histamine_on muscarinic_on trace-amine_on
5.56Consensusbb2_offOrthosteric Ligand7W41-BB2-PD176252
5.56Consensusbeta2_offOrthosteric Ligand2RH1-β2-S-Carazolol 6PS3-β2-S-Carvedilol 6PS5-β2-S-Propranolol 3D4S-β2-Timolol 3NY8-β2-ICI118-551 3NY9-β2-ICI118-551 6PRZ-β2-S-Alprenolol
5.56Consensusbeta_offOrthosteric Ligandbeta1_off beta2_off
5.56Consensusbombesin_offOrthosteric Ligandbb2_off
5.56Consensusd1_onOrthosteric Ligand7F0T-D1-Dopamine-Gs/β1/γ2 7CKY-D1-PW0464-Gs/β1/γ2 8IRR-D1-Rotigotine-Gs/β1/γ2 7JV5-D1-SKF81297-Gs/β1/γ2 7JVP-D1-SKF83959-Gs/β1/γ2 7X2D-D1-Tavapadon-Gs/β1/γ2 7CKX-D1-A77636-Gs/β1/γ2 7JVQ-D1-Apomorphine-Gs/β1/γ2 7CKW-D1-Fenoldopam-Gs/β1/γ2
5.56Consensusd4_onOrthosteric Ligand8IRU-D4-Rotigotine-chim(NtGi1-Gs-CtGi1)/β1/γ2
5.56Consensusgi_adrenergicOrthosteric Ligand7EJ0-α2a-L-Norepinephrine-Go/β1/γ2 7EJK-α2a-Oxymetazoline-Go/β1/γ2 7W7E-α2a-PubChem 164946676-Go/β1/γ2 7W6P-α2a-N-pyridin-4-ylisoquinolin-4-amine-Go/β1/γ2 7EJ8-α2a-Brimonidine-Go/β1/γ2 6K42-α2b-Dexmedetomidine-Gi1/β1/γ2 7EJA-α2a-Dexmedetomidine-Go/β1/γ2 7S0F-β1-Isoprenaline-Gi1/β1/γ2
5.56Consensusgs_amineOrthosteric Ligandgs_5ht gs_adrenergic gs_dopamine gs_histamine gs_trace-amine
5.56Consensush1_offOrthosteric Ligand8X63-H1-Mepyramine 3RZE-H1-Cidoxepin 8X5Y-H1-Astemizole
5.56Consensuslpa1_onOrthosteric Ligand7TD1-LPA1-LPA-Gi1/β1/γ2 7YU3-LPA1-ONO-0740556-Gi1/β1/γ2
5.56Consensuslpa1_on_gpOrthosteric Ligand7TD1-LPA1-LPA-Gi1/β1/γ2 7YU3-LPA1-ONO-0740556-Gi1/β1/γ2
5.56Consensusnucleotide_onOrthosteric Ligandadenosine_on p2y_on
5.26Single2YDVNECA2YDV-A2A-NECA
5.26Single3P0GBI1671073P0G-β2-BI167107
5.26Single3PDSHydroxybenzylisoproterenol3PDS-β2-Hydroxybenzylisoproterenol
5.26Single3SN6BI1671073SN6-β2-BI167107-Gs/β1/γ2
5.26Single3ZEVNeurotensin3ZEV-NTS1-Neurotensin
5.26Single4BV0Neurotensin4BV0-NTS1-Neurotensin
5.26Single4DJHJDTic4DJH-κ-JDTic
5.26Single4UHRCGS216804UHR-A2A-CGS21680
5.26Single4Z34ONO-97803074Z34-LPA1-ONO-9780307
5.26Single5A8E7-Methylcyanopindolol5A8E-β1-7-Methylcyanopindolol-Na
5.26Single5D5AS-Carazolol5D5A-β2-S-Carazolol
5.26Single5D5BS-Carazolol5D5B-β2-S-Carazolol
5.26Single5G53NECA5G53-A2A-NECA-Gs
5.26Single5TZRMK86665TZR-FFA1-MK8666
5.26Single5V56TC1145V56-SMO-TC114
5.26Single5XRAAM115425XRA-CB1-AM11542
5.26Single6DDEDamgo6DDE-μ-Damgo-Gi1/β1/γ2
5.26Single6E59L-7607356E59-NK1-L-760735
5.26Single6GT3Imaradenant6GT3-A2A-Imaradenant-Na
5.26Single6H7JIsoprenaline6H7J-β1-Isoprenaline
5.26Single6J20Aprepitant6J20-NK1-Aprepitant
5.26Single6J21Aprepitant6J21-NK1-Aprepitant
5.26Single6N48BI1671076N48-β2-BI167107-PubChem 138454256
5.26Single6NI3BI1671076NI3-β2-BI167107-Gs/β1/γ2
5.26Single6O3CCholesterol6O3C-SMO-SAG21k-Cholesterol
5.26Single6RZ5Zafirlukast6RZ5-CysLT1-Zafirlukast-Na
5.26Single6TQ7SB-3348676TQ7-OX1-SB-334867
5.26Single6WGTLSD6WGT-5-HT2A-LSD
5.26Single6Z8NSRI-98296Z8N-NTS1-SRI-9829
5.26Single7CKYPW04647CKY-D1-PW0464-Gs/β1/γ2
5.26Single7EW4CYM55417EW4-S1P3-CYM5541-Gi1/β1/γ2
5.26Single7EW7SEW28717EW7-S1P1-SEW2871-Gi1/β1/γ2
5.26Single7FEECP559407FEE-CB1-CP55940-ZCZ011
5.26Single7JJOIsoprenaline7JJO-β1-Isoprenaline-Gs/β1/γ2
5.26Single7JV5SKF812977JV5-D1-SKF81297-Gs/β1/γ2
5.26Single7JVPSKF839597JVP-D1-SKF83959-Gs/β1/γ2
5.26Single7L0PNeurotensin7L0P-NTS1-Neurotensin-Gi1/β1/γ1
5.26Single7L0QNeurotensin7L0Q-NTS1-Neurotensin-Gi1/β1/γ1
5.26Single7P2L4YI7P2L-mGlu5-4YI
5.26Single7PX4PSB-21137PX4-A2A-PSB-2113
5.26Single7T9NDPPC7T9N-TSH-M22 Fab-DPPC-Gs/β1/γ2
5.26Single7TD1LPA7TD1-LPA1-LPA-Gi1/β1/γ2
5.26Single7TUYGSK682753A7TUY-GPR183-GSK682753A
5.26Single7U2LPubChem 1632012427U2L-μ-PubChem 163201242-Gi1/β1/γ2
5.26Single7W6PN-pyridin-4-ylisoquinolin-4-amine7W6P-α2a-N-pyridin-4-ylisoquinolin-4-amine-Go/β1/γ2
5.26Single7W7EPubChem 1649466767W7E-α2a-PubChem 164946676-Go/β1/γ2
5.26Single7WV9CP559407WV9-CB1-CP55940-ZCZ011-Gi2/β1/γ2
5.26Single7XAVLanreotide7XAV-SST2-Lanreotide-Gi1/β1/γ2
5.26Single7XOWGastrin7XOW-CCKB-Gastrin-chim(NtGi1-Gq)/β1/γ2
5.26Single7XWONeurokinin-A7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
5.26Single7XY7NECA7XY7-A2B-NECA-chim(NtGi1-Gs)/β1/γ2
5.26Single7Y67C089 peptide7Y67-C5a1-C089 peptide-Gi1/β1/γ2
5.26Single7YU5ONO-07405567YU5-LPA1-ONO-0740556-Gi1/β1/γ2
5.26Single7YU7ONO-07405567YU7-LPA1-ONO-0740556-Gi1/β1/γ2
5.26Single8DCSCyanopindolol8DCS-β1-Cyanopindolol-Gs/β1/γ2
5.26Single8DZPmomSalB8DZP-κ-momSalB-Gi1/β1/γ2
5.26Single8E0GBU728E0G-μ-BU72
5.26Single8EFLSR170188EFL-μ-SR17018-Gi1/β1/γ2
5.26Single8FMZNeurotensin/Neuromedin-N8FMZ-NTS1-Neurotensin/Neuromedin-N-chim(NtGi2L-Gs-CtGq)/β1/γ2
5.26Single8FN1Neurotensin/Neuromedin-N8FN1-NTS1-Neurotensin/Neuromedin-N-chim(NtGi1-Go)/β1/γ2
5.26Single8HDOBAY 60-65838HDO-A2B-BAY 60-6583-Gs/β1/γ2
5.26Single8HPTC5a anaphylatoxin C-terminal peptide8HPT-C5a1-C5a anaphylatoxin C-terminal peptide-Go/β1/γ2
5.26Single8HQCC5a anaphylatoxin8HQC-C5a1-C5a anaphylatoxin-Go/β1/γ2
5.26Single8I9LC3a anaphylatoxin8I9L-C3aB-C3a anaphylatoxin-Go/β1/γ2
5.26Single8ID39-Hydroxystearic acid8ID3-FFA4-9-Hydroxystearic acid-Gi1/β1/γ2
5.26Single8ID6Oleic acid8ID6-FFA4-Oleic acid-Gi1/β1/γ2
5.26Single8IRRRotigotine8IRR-D1-Rotigotine-Gs/β1/γ2
5.26Single8IRURotigotine8IRU-D4-Rotigotine-chim(NtGi1-Gs-CtGi1)/β1/γ2
5.26Single8IRVRotigotine8IRV-D5-Rotigotine-chim(NtGi1-Gs)/β1/γ2
5.26Single8JBGNeurokinin-B8JBG-NK3-Neurokinin-B-chim(NtGi1-Gs-CtGq)/β1/γ2
5.26Single8JD5JNJ-40411813; ADX881788JD5-mGlu2; mGlu4-Glutamate-JNJ-40411813; ADX88178-Gi1/β1/γ2
5.26Single8JXVClozapine8JXV-H4-Clozapine-Gi1/β1/γ2
5.26Single8JZPC5A anaphylatoxin8JZP-C5a1-C5A anaphylatoxin-Go/β1/γ2
5.26Single8T1VPubChem 1183102098T1V-GPR6-PubChem 118310209-Na
5.26Single8UGWPubChem 30865998UGW-A2A-PubChem 3086599
5.26Single8VVEnorBNI8VVE-κ-norBNI-Gi1/β1/γ2
5.26Single8VVFJDTic8VVF-κ-JDTic-Gi1/β1/γ2
5.26Single8X0BVU04244658X0B-mGlu5; mGlu5-Quisqualate-VU0424465
5.26Single8X0FVU04244658X0F-mGlu5; mGlu5-Quisqualate-VU0424465
5.26Single8X16Piclidenoson8X16-A3A-Piclidenoson-Gi1/β1/γ2
5.26Single8XIPPasireotide8XIP-SST1-Pasireotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
5.26Single8XVLZibotentan8XVL-ETA-Zibotentan
5.26Single8Y73Peptide8Y73-μ-Peptide-MPAM-15-Gi1/β1/γ2
5.26Single8YH6Namodenoson8YH6-A3A-Namodenoson-Gi1/β1/γ2
5.26Single8ZWFJR14a8ZWF-C3aB-JR14a
5.26Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/β1/γ2
5.26Single9B65KCA9B65-CB1-KCA-Gi1/β1/γ2
5.26Single9BJKNaloxone9BJK-μ-Naloxone-NAM
5.26Single9CLWTUG-13759CLW-FFA2-TUG-1375-4-CMTB-chim(NtGi1L-Gs-CtGq)/β1/γ2
5.26Single9I54A1IZV9I54-D1-A1IZV-Gs/β1/γ2
5.26Single9IJDCarazolol9IJD-β3-Carazolol-chim(NtGi1-Gs)/β1/γ2
5.26Single9IK9SST analogue9IK9-SST1-SST analogue-Gi1/β1/γ2
5.26Single9IZGNKP9IZG-LPA1-NKP-chim(NtGi1-Gs-CtGq)/β1/γ2
5.26Single9JMCDS-3801b9JMC-Motilin-DS-3801b-chim(Gs-CtGq)/β1/γ2
5.26Consensusa2_onOrthosteric Liganda2b_on
5.26Consensusa2_on_gpOrthosteric Liganda2b_on_gp
5.26Consensusa2b_onOrthosteric Ligand8HDP-A2B-Adenosine-Gs/β1/γ2 7XY6-A2B-BAY 60-6583-chim(NtGi1-Gs)/β1/γ2 7XY7-A2B-NECA-chim(NtGi1-Gs)/β1/γ2 8HDO-A2B-BAY 60-6583-Gs/β1/γ2
5.26Consensusa2b_on_gpOrthosteric Ligand8HDP-A2B-Adenosine-Gs/β1/γ2 7XY6-A2B-BAY 60-6583-chim(NtGi1-Gs)/β1/γ2 7XY7-A2B-NECA-chim(NtGi1-Gs)/β1/γ2 8HDO-A2B-BAY 60-6583-Gs/β1/γ2
5.26Consensusamine_on_gpOrthosteric Ligand5ht_on_gp adrenergic_on_gp dopamine_on_gp histamine_on_gp muscarinic_on_gp trace-amine_on_gp
5.26Consensusbeta1_offOrthosteric Ligand2VT4-β1-Cyanopindolol 2YCW-β1-S-Carazolol 2YCZ-β1-Iodocyanopindolol 5A8E-β1-7-Methylcyanopindolol-Na 3ZPQ-β1-4-(piperazin-1- yl)-1H-indole-Na 3ZPR-β1-4-methyl-2-(piperazin-1-yl)-Na
5.26Consensusbeta2_onOrthosteric Ligand7DHI-β2-Salbutamol-Gs/β1/γ2 6NI3-β2-BI167107-Gs/β1/γ2
5.26Consensusbeta2_on_gpOrthosteric Ligand7DHI-β2-Salbutamol-Gs/β1/γ2 6NI3-β2-BI167107-Gs/β1/γ2
5.26Consensusclass-a_offOrthosteric Ligandsensory_off alicarboxylic_off amine_off lipid_off nucleotide_off peptide_off protein_off
5.26Consensuscyslt1_offOrthosteric Ligand6RZ5-CysLT1-Zafirlukast-Na 6RZ4-CysLT1-Pranlukast-Na
5.26Consensusd1_on_gpOrthosteric Ligand7F0T-D1-Dopamine-Gs/β1/γ2 7CKY-D1-PW0464-Gs/β1/γ2 8IRR-D1-Rotigotine-Gs/β1/γ2 7JV5-D1-SKF81297-Gs/β1/γ2 7JVP-D1-SKF83959-Gs/β1/γ2 7X2D-D1-Tavapadon-Gs/β1/γ2 7CKX-D1-A77636-Gs/β1/γ2 7JVQ-D1-Apomorphine-Gs/β1/γ2 7CKW-D1-Fenoldopam-Gs/β1/γ2
5.26Consensusd4_on_gpOrthosteric Ligand8IRU-D4-Rotigotine-chim(NtGi1-Gs-CtGi1)/β1/γ2
5.26Consensusd5_on_gpOrthosteric Ligand8IRV-D5-Rotigotine-chim(NtGi1-Gs)/β1/γ2
5.26Consensusffa2_onOrthosteric Ligand8J22-FFA2-TUG-1375-Gi1/β1/γ2
5.26Consensusgi_5htOrthosteric Ligand8FYT-5-HT1A-LSD-Gi1/β1/γ1 7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/β1/γ2 8UGY-5-HT1E-Mianserin-Gi1/β1/γ1 8W8B-5-HT1A-SEP-363856-Gi1/β1/γ2 7E2Y-5-HT1A-Serotonin-Gi1/β1/γ2 7E32-5-HT1D-Serotonin-Gi1/β1/γ2 7XTA-5-HT4-Serotonin-Gi1/β1/γ2 8UH3-5-HT1E-Setiptiline-Gi1/β1/γ1 8JSP-5-HT1A-Ulotaront-Gi1/β1/γ2 8FYL-5-HT1A-Vilazodone-Gi1/β1/γ1 8JT6-5-HT1A-(R)-IHCH-7179-Gi1/β1/γ2 8FYE-5-HT1A-4-F,5-MeO-PyrT-Gi1/β1/γ1 7X5H-5-HT5A-5-CT-Gi1/β1/γ2 8FY8-5-HT1A-5-MeO-DMT-Gi1/β1/γ1 7E2Z-5-HT1A-Aripiprazole-Gi1/β1/γ2 7E33-5-HT1E-BRL-54443-Gi1/β1/γ2 8FYX-5-HT1A-Buspirone-Gi1/β1/γ1 7EXD-5-HT1F-Lasmiditan-Gi1/β1/γ2 7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/β1/γ2
5.26Consensusgi_dopamineOrthosteric Ligand7JVR-D2-Bromoergocryptine-Gi1/β1/γ2 7CMV-D3-PD128907-Gi1/β1/γ2 7CMU-D3-Pramipexole-Gi1/β1/γ2 8IRS-D2-Rotigotine-Gi1/β1/γ2 8IRT-D3-Rotigotine-Gi1/β1/γ2
5.26Consensusgi_lpaOrthosteric Ligand7TD1-LPA1-LPA-Gi1/β1/γ2 7YU3-LPA1-ONO-0740556-Gi1/β1/γ2
5.26Consensusgs_adenosineOrthosteric Ligand8HDP-A2B-Adenosine-Gs/β1/γ2 8HDO-A2B-BAY 60-6583-Gs/β1/γ2 7XY7-A2B-NECA-chim(NtGi1-Gs)/β1/γ2 7XY6-A2B-BAY 60-6583-chim(NtGi1-Gs)/β1/γ2
5.26Consensusgs_dopamineOrthosteric Ligand7F0T-D1-Dopamine-Gs/β1/γ2 7CKW-D1-Fenoldopam-Gs/β1/γ2 7CKY-D1-PW0464-Gs/β1/γ2 8IRV-D5-Rotigotine-chim(NtGi1-Gs)/β1/γ2 8IRR-D1-Rotigotine-Gs/β1/γ2 7JV5-D1-SKF81297-Gs/β1/γ2 7JVP-D1-SKF83959-Gs/β1/γ2 7X2D-D1-Tavapadon-Gs/β1/γ2 7CKX-D1-A77636-Gs/β1/γ2 7JVQ-D1-Apomorphine-Gs/β1/γ2
5.26Consensusgs_nucleotideOrthosteric Ligandgs_adenosine
5.26Consensuskop_offOrthosteric Ligand4DJH-κ-JDTic
5.26Consensuslpa_onOrthosteric Ligandlpa1_on
5.26Consensuslpa_on_gpOrthosteric Ligandlpa1_on_gp
5.26Consensusmotilin_onOrthosteric Ligand8IBU-Motilin-Erythromycin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
5.26Consensusneurotensin_onOrthosteric Ligandnts1_on
5.26Consensusnk2_on_gpOrthosteric Ligand7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
5.26Consensusnts1_onOrthosteric Ligand6OSA-NTS1-JMV449-Gi1/β1/γ2 7L0S-NTS1-Neurotensin-Gi1/β1/γ1
5.26Consensustachykinin_offOrthosteric Ligandnk1_off
5.00Single2YCXCyanopindolol2YCX-β1-Cyanopindolol
5.00Single3D4STimolol3D4S-β2-Timolol
5.00Single4AMIBucindolol4AMI-β1-Bucindolol
5.00Single4GRVNeurotensin-(8-13)4GRV-NTS1-Neurotensin-(8-13)
5.00Single4LDEBI1671074LDE-β2-BI167107
5.00Single4N4WSANT-14N4W-SMO-SANT-1
5.00Single4OR2FITM4OR2-mGlu1; mGlu1-FITM
5.00Single4PY02MeSATP4PY0-P2Y12-2MeSATP
5.00Single4RWADIPP-NH24RWA-δ-DIPP-NH2
5.00Single4XEENeurotensin4XEE-NTS1-Neurotensin
5.00Single4XESNeurotensin4XES-NTS1-Neurotensin
5.00Single4Z36ONO-30805734Z36-LPA1-ONO-3080573
5.00Single5F8UCyanopindolol5F8U-β1-Cyanopindolol
5.00Single5TZYMK8666; AP85TZY-FFA1-MK8666; AP8
5.00Single6H7OCyanopindolol6H7O-β1-Cyanopindolol
5.00Single6KQICP559406KQI-CB1-CP55940-Org27569
5.00Single6MXTSalmeterol6MXT-β2-Salmeterol
5.00Single6OSAJMV4496OSA-NTS1-JMV449-Gi1/β1/γ2
5.00Single6VMSBromoergocryptine6VMS-D2-Bromoergocryptine-Gi1/β1/γ2
5.00Single6XBLCholesterol6XBL-SMO-SAG-Cholesterol-Gi1/β1/γ2
5.00Single7EO4BAF3127EO4-S1P1-BAF312-Gi1/β1/γ2
5.00Single7EPENAM5637EPE-mGlu2; mGlu2-NAM563
5.00Single7EVYSiponimod7EVY-S1P1-Siponimod-Gi1/β1/γ2
5.00Single7EW2Fingolimod7EW2-S1P3-Fingolimod-Gi1/β1/γ2
5.00Single7L0SNeurotensin7L0S-NTS1-Neurotensin-Gi1/β1/γ1
5.00Single7L1UOrexin7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/β1/γ2
5.00Single7L1VPubChem 1554910097L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/β1/γ2
5.00Single7MTRADX551647MTR-mGlu2; mGlu2-Glutamate-ADX55164
5.00Single7SUSPubChem 1227019087SUS-Apelin-PubChem 122701908
5.00Single7W0LPubChem 1227019087W0L-Apelin-PubChem 122701908-Gi1/β1/γ2
5.00Single7XMTJ-21567XMT-SST4-J-2156-Gi1/β1/γ2
5.00Single7Y66BM2137Y66-C5a1-BM213-Gi1/β1/γ2
5.00Single7YITNalfurafine7YIT-κ-Nalfurafine
5.00Single7YMJTamsulosin7YMJ-Alpha1A-Tamsulosin
5.00Single8E9W2-Deoxycytidine8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/β1/γ2
5.00Single8FYE4-F,5-MeO-PyrT8FYE-5-HT1A-4-F,5-MeO-PyrT-Gi1/β1/γ1
5.00Single8H0QGastrin Releasing Peptide8H0Q-BB2-Gastrin Releasing Peptide-chim(NtGi1-Gs-CtGq)/β1/γ2
5.00Single8HK2C3a anaphylatoxin8HK2-C3aB-C3a anaphylatoxin-Gi1/β1/γ2
5.00Single8I9AEP548I9A-C3aB-EP54-chim(NtGi1-Gs-CtGq)/β1/γ2
5.00Single8IA8E7 peptide8IA8-C3aB-E7 peptide-Gi1/β1/γ2
5.00Single8IBUErythromycin-A8IBU-Motilin-Erythromycin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
5.00Single8IRSRotigotine8IRS-D2-Rotigotine-Gi1/β1/γ2
5.00Single8JD3JNJ-404118138JD3-mGlu2; mGlu3-Glutamate-JNJ-40411813-Gi1/β1/γ2
5.00Single8JJ8Formoterol8JJ8-β2-Formoterol
5.00Single8JJLOlodaterol8JJL-β2-Olodaterol
5.00Single8JJPChemerin8JJP-CML2-Chemerin-Gi1/β1/γ2
5.00Single8JPBNeurotensin-(8-13)8JPB-NTS1-Neurotensin-(8-13)-SBI-553; GDP; Mg-Gq; GRK2
5.00Single8JWY2-1188JWY-A2A-2-118
5.00Single8JWZAB9288JWZ-A2A-AB928-Na
5.00Single8T3QDocosa-4,7,10,13,16,19-Hexaenoic acid8T3Q-FFA4-Docosa-4,7,10,13,16,19-Hexaenoic acid-chim(NtGi2L-Gs-CtGq)/β1/γ2
5.00Single8U26Protachykinin-18U26-NK1-Protachykinin-1-Gs/β1/γ2
5.00Single8W1VPubChem 1717162658W1V-β2-PubChem 171716265
5.00Single8XQJJN2418XQJ-Apelin-JN241
5.00Single8Y6WTUG-13758Y6W-FFA2-TUG-1375-4-CMTB-Gi1/β1/γ2
5.00Single9CM3TUG-13759CM3-FFA2-TUG-1375-Compound 187-chim(NtGi1L-Gs-CtGq)/β1/γ2
5.00Single9EBIPiclidenoson9EBI-A3A-Piclidenoson-chim(NtGi1L-Gs-CtGi1)/β1/γ2
5.00Single9GYOP3959GYO-GPBA-P395-chim(NtGi1-Gs)/β1/γ2
5.00Single9IZHLPA9IZH-LPA1-LPA-chim(NtGi2-G13)/β1/γ2
5.00Single9L3WRetinoic acid receptor responder protein 29L3W-CML1-Retinoic acid receptor responder protein 2-Gi1/β1/γ2
5.00Single9MQLIsoquinuclidine9MQL-κ-Isoquinuclidine
5.00Consensusalpha1_offOrthosteric Ligandalpha1a_off
5.00Consensusalpha1a_offOrthosteric Ligand7YMJ-Alpha1A-Tamsulosin
5.00Consensusbeta_onOrthosteric Ligandbeta1_on beta2_on beta3_on
5.00Consensusbeta_on_gpOrthosteric Ligandbeta1_on_gp beta2_on_gp beta3_on_gp
5.00Consensusc3a_onOrthosteric Ligand8HK2-C3aB-C3a anaphylatoxin-Gi1/β1/γ2 8IA8-C3aB-E7 peptide-Gi1/β1/γ2
5.00Consensuscb1_onOrthosteric Ligand6KPG-CB1-AM841-Gi1/β1/γ2 8K8J-CB1-Fenofibrate-chim(Gs-CtGq)/β1/γ2
5.00Consensusccr8_onOrthosteric Ligand8KFX-CCR8-LMD-009-Gi1/β1/γ2 8KFY-CCR8-ZK-756326-Gi1/β1/γ2 8U1U-CCR8-CCL1-Gi1/β1/γ2
5.00Consensusd2_on_gpOrthosteric Ligand7JVR-D2-Bromoergocryptine-Gi1/β1/γ2 8IRS-D2-Rotigotine-Gi1/β1/γ2
5.00Consensusffa2_on_gpOrthosteric Ligand8J22-FFA2-TUG-1375-Gi1/β1/γ2
5.00Consensusgi_amineOrthosteric Ligandgi_5ht gi_muscarinic gi_adrenergic gi_dopamine gi_histamine
5.00Consensusgi_lipidOrthosteric Ligandgi_cannabinoid gi_ffa gi_leukotriene gi_lpa gi_s1p
5.00Consensusgi_neurotensinOrthosteric Ligand6OSA-NTS1-JMV449-Gi1/β1/γ2 7L0S-NTS1-Neurotensin-Gi1/β1/γ1
5.00Consensuskop_onOrthosteric Ligand8F7W-κ-Dynorphin-Gi1/β1/γ2 8DZS-κ-GR89,696-chim(NtGi2-Gz)/β1/γ2 8DZP-κ-momSalB-Gi1/β1/γ2
5.00Consensusleukotriene_offOrthosteric Ligandblt_off cyslt_off
5.00Consensuslipid_offonOrthosteric Ligandlipid_off lipid_on
5.00Consensuslipid_offon_gpOrthosteric Ligandlipid_on_gp lipid_off
5.00Consensuslpa1_offOrthosteric Ligand4Z36-LPA1-ONO-3080573 4Z35-LPA1-ONO-9910539 4Z34-LPA1-ONO-9780307
5.00Consensuslpa_offOrthosteric Ligandlpa1_off
5.00Consensuslpl_offOrthosteric Ligands1p_off lpa_off
5.00Consensusmop_onOrthosteric Ligand8F7R-μ-Endomorphin-Gi1/β1/γ2 8EF5-μ-Fentanyl-Gi1/β1/γ2 7SCG-μ-FH210-Gi1/β1/γ2 7T2H-μ-Lofentanil-Gi1/β1/γ2 7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2 8EF6-μ-Morphine-Gi1/β1/γ2 8EFB-μ-Oliceridine-Gi1/β1/γ2 7U2L-μ-PubChem 163201242-Gi1/β1/γ2 8EFO-μ-PZM21-Gi1/β1/γ2 8EFL-μ-SR17018-Gi1/β1/γ2 8F7Q-μ-β-Endorphin-Gi1/β1/γ2 7U2K-μ-C6-guano-Gi1/β1/γ2 8EFQ-μ-Damgo-Gi1/β1/γ2
5.00Consensusmop_on_gpOrthosteric Ligand8F7R-μ-Endomorphin-Gi1/β1/γ2 8EF5-μ-Fentanyl-Gi1/β1/γ2 7SCG-μ-FH210-Gi1/β1/γ2 7T2H-μ-Lofentanil-Gi1/β1/γ2 7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2 8EF6-μ-Morphine-Gi1/β1/γ2 8EFB-μ-Oliceridine-Gi1/β1/γ2 7U2L-μ-PubChem 163201242-Gi1/β1/γ2 8EFO-μ-PZM21-Gi1/β1/γ2 8EFL-μ-SR17018-Gi1/β1/γ2 8F7Q-μ-β-Endorphin-Gi1/β1/γ2 7U2K-μ-C6-guano-Gi1/β1/γ2 8EFQ-μ-Damgo-Gi1/β1/γ2
5.00Consensusmotilin_on_gpOrthosteric Ligand8IBU-Motilin-Erythromycin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
5.00Consensusneurotensin_on_gpOrthosteric Ligandnts1_on_gp
5.00Consensusnk1_offOrthosteric Ligand6HLP-NK1-Netupitant 6HLO-NK1-Aprepitant 6HLL-NK1-CP99994 6E59-NK1-L-760735
5.00Consensusnts1_on_gpOrthosteric Ligand6OSA-NTS1-JMV449-Gi1/β1/γ2 7L0S-NTS1-Neurotensin-Gi1/β1/γ1
5.00Consensusopioid_offOrthosteric Ligandmop_off nop_off dop_off kop_off
5.00Consensusorexin_onOrthosteric Ligandox2_on
5.00Consensuss1p1_onOrthosteric Ligand7VIE-S1P1-S1P-Gi1/β1/γ2 7VIF-S1P1-S-FTY720-P-Gi1/β1/γ2 7VIG-S1P1-CBP-307-Gi1/β1/γ2 7EVY-S1P1-Siponimod-Gi1/β1/γ2 7EVZ-S1P1-Cenerimod-Gi1/β1/γ2 7EW0-S1P1-Ozanimod-Gi1/β1/γ2 7EW7-S1P1-SEW2871-Gi1/β1/γ2
5.00Consensuss1p1_on_gpOrthosteric Ligand7VIE-S1P1-S1P-Gi1/β1/γ2 7VIF-S1P1-S-FTY720-P-Gi1/β1/γ2 7VIG-S1P1-CBP-307-Gi1/β1/γ2 7EVY-S1P1-Siponimod-Gi1/β1/γ2 7EVZ-S1P1-Cenerimod-Gi1/β1/γ2 7EW0-S1P1-Ozanimod-Gi1/β1/γ2 7EW7-S1P1-SEW2871-Gi1/β1/γ2
5.00Consensuss1p3_onOrthosteric Ligand7EW3-S1P3-S1P-Gi1/β1/γ2 7EW4-S1P3-CYM5541-Gi1/β1/γ2 7EW2-S1P3-Fingolimod-Gi1/β1/γ2
4.88Single8GY7Corticotropin8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1
4.76Single2YCZIodocyanopindolol2YCZ-β1-Iodocyanopindolol
4.76Single4BUONeurotensin4BUO-NTS1-Neurotensin
4.76Single4BVNCyanopindolol4BVN-β1-Cyanopindolol-Na
4.76Single4OR2FITM4OR2-mGlu1; mGlu1-FITM
4.76Single4Z35ONO-99105394Z35-LPA1-ONO-9910539
4.76Single5X93K-87945X93-ETB-K-8794
4.76Single6BQGErgotamine6BQG-5-HT2C-Ergotamine
4.76Single6DDFDamgo6DDF-μ-Damgo-Gi1/β1/γ2
4.76Single6H7LDobutamine6H7L-β1-Dobutamine
4.76Single6IBLArformoterol6IBL-β1-Arformoterol
4.76Single6K1QIRL25006K1Q-ETB-IRL2500
4.76Single6TKOArformoterol6TKO-β1-Arformoterol-Arrestin2
4.76Single6UP7Neurotensin6UP7-NTS1-Neurotensin-Arrestin2
4.76Single7EVZCenerimod7EVZ-S1P1-Cenerimod-Gi1/β1/γ2
4.76Single7EW0Ozanimod7EW0-S1P1-Ozanimod-Gi1/β1/γ2
4.76Single7EZCUKA7EZC-A2A-UKA
4.76Single7EZHCholecystokinin-87EZH-CCKA-Cholecystokinin-8-Gi1/β1/γ2
4.76Single7EZMCholecystokinin-87EZM-CCKA-Cholecystokinin-8-chim(NtGsL-Gq)/β1/γ2
4.76Single7MBYCholecystokinin-87MBY-CCKA-Cholecystokinin-8-chim(NtGi1L-Gs-CtGq)/β1/γ2
4.76Single7MTSADX551647MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/β1/γ2
4.76Single7P00Substance-P7P00-NK1-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
4.76Single7PIUSetmelanotide7PIU-MC4-Setmelanotide-Gs/β1/γ2
4.76Single7QVMOxytocin7QVM-OT-Oxytocin-chim(NtGi1-Go-CtGq)/β1/γ2
4.76Single7UM4AS26747237UM4-5-HT5A-AS2674723
4.76Single7WVVfMLFII7WVV-FPR2-ALX-fMLFII-Gi2/β1/γ2
4.76Single7X1UTRH7X1U-TRH-TRH-chim(NtGi2L-Gs-CtGq)/β1/γ2
4.76Single7X2DTavapadon7X2D-D1-Tavapadon-Gs/β1/γ2
4.76Single7YU8ONO-07405567YU8-LPA1-ONO-0740556-Gi1/β1/γ2
4.76Single8E9X2-Deoxycytidine8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/β1/γ2
4.76Single8E9YClozapine-N-oxide8E9Y-M3-Clozapine-N-oxide-chim(NtGi2L-Gs-CtGq)/β1/γ2
4.76Single8FN0Neurotensin/Neuromedin-N8FN0-NTS1-Neurotensin/Neuromedin-N-SBI-553-chim(NtGi1-Go)/β1/γ2
4.76Single8FX5Xanomeline8FX5-M4-Xanomeline-Xanomeline-Gi1/β1/γ2
4.76Single8GUTLEI-1028GUT-CB2-LEI-102-Gi1/β1/γ2
4.76Single8HN1Toxin AdTx18HN1-Alpha1A-Toxin AdTx1
4.76Single8I95EP548I95-C3aB-EP54-Go/β1/γ2
4.76Single8ID8TUG-8918ID8-FFA4-TUG-891-Gi1/β1/γ2
4.76Single8IYSTUG-8918IYS-FFA4-TUG-891-GDP-chim(NtGi1L-Gq)/β1/γ2
4.76Single8JPFNeurotensin8JPF-NTS1-Neurotensin-SBI-553
4.76Single8S2TIsoprenaline8S2T-β1-Isoprenaline-chim(NtGi1-Gs)/β1/γ2
4.76Single8T3OTUG-8918T3O-FFA4-TUG-891-chim(NtGi2L-Gs-CtGq)/β1/γ2
4.76Single8WRZPubChem 1023367048WRZ-CB1-PubChem 102336704-Arrestin2
4.76Single8XGSMetastin8XGS-Kiss1-Metastin-chim(NtGi1-Gq)/β1/γ2
4.76Single8XIOL7975918XIO-SST1-L797591-chim(NtGi1-Gs-CtGi1)/β1/γ2
4.76Single8XVJMacitentan8XVJ-ETA-Macitentan
4.76Single8ZWGJR14a8ZWG-C3aB-JR14a-Gi1/β1/γ2
4.76Single9CGJC6-Quino9CGJ-δ-C6-Quino-Gi1/β1/γ2
4.76Single9GE3Lysophosphatidylinositol9GE3-GPR55-Lysophosphatidylinositol-chim(NtGi1-G13)/β1/γ2
4.76Single9IZFNKP9IZF-LPA1-NKP-Gi1/β1/γ2
4.76Single9M54Neuropeptide VF9M54-NPFF2-Neuropeptide VF-Gi1/β1/γ2
4.76Consensusbeta1_onOrthosteric Ligand8DCR-β1-Dobutamine-Gs/β1/γ2 7S0F-β1-Isoprenaline-Gi1/β1/γ2
4.76Consensusbeta1_on_gpOrthosteric Ligand8DCR-β1-Dobutamine-Gs/β1/γ2 7S0F-β1-Isoprenaline-Gi1/β1/γ2
4.76Consensusc3a_on_gpOrthosteric Ligand8HK2-C3aB-C3a anaphylatoxin-Gi1/β1/γ2 8IA8-C3aB-E7 peptide-Gi1/β1/γ2
4.76Consensuscb1_on_gpOrthosteric Ligand6KPG-CB1-AM841-Gi1/β1/γ2 8K8J-CB1-Fenofibrate-chim(Gs-CtGq)/β1/γ2
4.76Consensuscck_onOrthosteric Ligandccka_on cckb_on
4.76Consensuscck_on_gpOrthosteric Ligandccka_on_gp cckb_on_gp
4.76Consensusccka_onOrthosteric Ligand7EZH-CCKA-Cholecystokinin-8-Gi1/β1/γ2
4.76Consensusccka_on_gpOrthosteric Ligand7EZH-CCKA-Cholecystokinin-8-Gi1/β1/γ2
4.76Consensusendothelin_offOrthosteric Ligandetb_off
4.76Consensusetb_offOrthosteric Ligand5X93-ETB-K-8794 5XPR-ETB-Bosentan 6K1Q-ETB-IRL2500
4.76Consensusgi_s1pOrthosteric Ligand7VIE-S1P1-S1P-Gi1/β1/γ2 7EW3-S1P3-S1P-Gi1/β1/γ2 7EVY-S1P1-Siponimod-Gi1/β1/γ2 7EW1-S1P5-Siponimod-Gi1/β1/γ2 7VIF-S1P1-S-FTY720-P-Gi1/β1/γ2 7VIG-S1P1-CBP-307-Gi1/β1/γ2 7EVZ-S1P1-Cenerimod-Gi1/β1/γ2 7EW4-S1P3-CYM5541-Gi1/β1/γ2 7EW2-S1P3-Fingolimod-Gi1/β1/γ2 7EW0-S1P1-Ozanimod-Gi1/β1/γ2 7EW7-S1P1-SEW2871-Gi1/β1/γ2
4.76Consensuskop_on_gpOrthosteric Ligand8F7W-κ-Dynorphin-Gi1/β1/γ2 8DZS-κ-GR89,696-chim(NtGi2-Gz)/β1/γ2 8DZP-κ-momSalB-Gi1/β1/γ2
4.76Consensusnk1_onOrthosteric Ligand7P00-NK1-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
4.76Consensusnk1_on_gpOrthosteric Ligand7P00-NK1-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
4.76Consensusnk2_onOrthosteric Ligand7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
4.76Consensusnucleotide_on_gpOrthosteric Ligandadenosine_on_gp p2y_on_gp
4.76Consensusorexin_on_gpOrthosteric Ligandox2_on_gp
4.76Consensuspeptide_offOrthosteric Ligandcck_off angiotensin_off bombesin_off endothelin_off ghrelin_off npy_off opioid_off orexin_off somatostatin_off tachykinin_off vasop-oxy_off neurotensin_off
4.55Single3NY9ICI118-5513NY9-β2-ICI118-551
4.55Single4UG2CGS216804UG2-A2A-CGS21680
4.55Single5VBLApelin mimetic peptide agonist5VBL-Apelin-Apelin mimetic peptide agonist
4.55Single5WF6UK-4320975WF6-A2A-UK-432097
4.55Single5ZTYAM102575ZTY-CB2-AM10257
4.55Single6C1QPMX536C1Q-C5a1-PMX53-NDT9513727
4.55Single6G79Donitriptan6G79-5-HT1B-Donitriptan-Go/β1/γ2
4.55Single6OS9JMV4496OS9-NTS1-JMV449-Gi1/β1/γ2
4.55Single6PT3DPI-2876PT3-δ-DPI-287
4.55Single6XBJCholesterol6XBJ-SMO-Cholesterol-Gi1/β1/γ2
4.55Single7AUESetmelanotide7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2
4.55Single7F2OBradykinin7F2O-BK2-Bradykinin-chim(NtGi1-Gs-CtGq)/β1/γ2
4.55Single7F8WGastrin-177F8W-CCKB-Gastrin-17-chim(NtGsL-Gq)/β1/γ2
4.55Single7RKNFractalkine7RKN-US28-Fractalkine-Gi1/β1/γ2
4.55Single7RMGSubstance-P7RMG-NK1-Substance-P-chim(Gs-CtGq)/β1/γ2
4.55Single7RMHSubstance-P7RMH-NK1-Substance-P-Gs/β1/γ2
4.55Single7T11Octreotide7T11-SST2-Octreotide-Gi3/β1/γ2
4.55Single7XN9L-054,5227XN9-SST2-L-054,522
4.55Single7XY6BAY 60-65837XY6-A2B-BAY 60-6583-chim(NtGi1-Gs)/β1/γ2
4.55Single7Y1FDynorphin7Y1F-κ-Dynorphin-Gi1/β1/γ2
4.55Single7YAEOctreotide7YAE-SST2-Octreotide-Gi1/β1/γ2
4.55Single8F7REndomorphin8F7R-μ-Endomorphin-Gi1/β1/γ2
4.55Single8IA7Cholecystokinin-88IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/β1/γ2
4.55Single8JBFSenktide8JBF-NK3-Senktide-chim(NtGi1-Gs-CtGq)/β1/γ2
4.55Single8QJ2pN1628QJ2-MC4-pN162-Gs
4.55Single8X3LXWD8X3L-CB2-XWD-Gi1/β1/γ2
4.55Single8X5YAstemizole8X5Y-H1-Astemizole
4.55Single8XQJJN2418XQJ-Apelin-JN241
4.55Single8Y72Peptide8Y72-μ-Peptide-BMS-986122-Gi1/β1/γ2
4.55Single8Z74Agonistic antibody8Z74-Apelin-Agonistic antibody
4.55Single8Z74Agonistic antibody8Z74-Apelin-Agonistic antibody
4.55Single9CGKC5-Quino9CGK-δ-C5-Quino-Gi1/β1/γ2
4.55Single9IPVJR14a9IPV-C3aB-JR14a-Gi1/β1/γ2
4.55Single9IPYJR14a9IPY-C3aB-JR14a
4.55Single9JH6C20:0 Ceramide9JH6-CysLT2-C20:0 Ceramide-chim(NtGi1-Gs-CtGq)/β1/γ2
4.55Single9M0RNeuropeptide VF9M0R-NPFF1-Neuropeptide VF-Gi1/β1/γ2
4.55Single9V2NMacimorelin9V2N-Ghrelin-Macimorelin-chim(NtGi1-Gs-CtGq)/β1/γ2
4.55Consensuscb2_offOrthosteric Ligand5ZTY-CB2-AM10257
4.55Consensusdop_onOrthosteric Ligand8F7S-δ-Deltorphin-Gi1/β1/γ2
4.55Consensusgq_cckOrthosteric Ligand8IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/β1/γ2 7XOW-CCKB-Gastrin-chim(NtGi1-Gq)/β1/γ2 7EZM-CCKA-Cholecystokinin-8-chim(NtGsL-Gq)/β1/γ2 7F8W-CCKB-Gastrin-17-chim(NtGsL-Gq)/β1/γ2
4.55Consensuskiss1_onOrthosteric Ligand8ZJD-Kiss1-Kisspeptin-10-chim(NtGi1-Gq)/β1/γ1
4.55Consensuskisspeptin_onOrthosteric Ligandkiss1_on
4.55Consensusnmur1_onOrthosteric Ligand7W53-NMUR1-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
4.55Consensusox2_onOrthosteric Ligand7L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/β1/γ2 7SQO-OX2-TAK-925-Gi1/β1/γ2 7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/β1/γ2
4.55Consensusox2_on_gpOrthosteric Ligand7L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/β1/γ2 7SQO-OX2-TAK-925-Gi1/β1/γ2 7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/β1/γ2
4.55Consensuss1p_onOrthosteric Ligands1p1_on s1p3_on s1p5_on
4.55Consensuss1p_on_gpOrthosteric Ligands1p1_on_gp s1p3_on_gp s1p5_on_gp
4.55Consensussst2_onOrthosteric Ligand7WIC-SST2-Somatostatin-14-Gi1/β1/γ2 7WIG-SST2-L-054,264-Gi1/β1/γ2 7YAE-SST2-Octreotide-Gi1/β1/γ2 7YAC-SST2-Paltusotine-Gi1/β1/γ2
4.55Consensussst2_on_gpOrthosteric Ligand7WIC-SST2-Somatostatin-14-Gi1/β1/γ2 7WIG-SST2-L-054,264-Gi1/β1/γ2 7YAE-SST2-Octreotide-Gi1/β1/γ2 7YAC-SST2-Paltusotine-Gi1/β1/γ2
4.35Single4AMJS-Carvedilol4AMJ-β1-S-Carvedilol
4.35Single4IARErgotamine4IAR-5-HT1B-Ergotamine
4.35Single4IB4Ergotamine4IB4-5-HT2B-Ergotamine
4.35Single6WIVPubChem 52923113; PubChem 529246456WIV-GABAB1, GABAB2-PubChem 52923113; PubChem 52924645
4.35Single7F4ISHU91197F4I-MC1-SHU9119-chim(NtGi1-Gs)/β1/γ2
4.35Single7F8XNN90567F8X-CCKA-NN9056
4.35Single7L0RNeurotensin7L0R-NTS1-Neurotensin-Gi1/β1/γ1
4.35Single7NA7Ghrelin-277NA7-Ghrelin-Ghrelin-27-Gi1/β1/γ2
4.35Single7TD4Siponimod7TD4-S1P1-Siponimod-Gi1/β1/γ2
4.35Single7W0PElabela7W0P-Apelin-Elabela-Gi1/β1/γ2
4.35Single7W2ZGhrelin7W2Z-Ghrelin-Ghrelin-Go/β1/γ2
4.35Single7W53Neuromedin-U-257W53-NMUR1-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
4.35Single7WKDTRH7WKD-TRH-TRH-chim(NtGi1-Gs-CtGq)/β1/γ2
4.35Single7XMRSomatostatin-147XMR-SST2-Somatostatin-14-Gi1/β1/γ2
4.35Single8DCRDobutamine8DCR-β1-Dobutamine-Gs/β1/γ2
4.35Single8F7XNociceptin8F7X-NOP-Nociceptin-Gi1/β1/γ2
4.35Single8FYLVilazodone8FYL-5-HT1A-Vilazodone-Gi1/β1/γ1
4.35Single8GHVAMG3158GHV-CB1-AMG315-Gi1/β1/γ2
4.35Single8IEBA1LYA8IEB-GPR156-A1LYA
4.35Single8IEIA1LYA8IEI-GPR156-A1LYA
4.35Single8IEIA1LYA8IEI-GPR156-A1LYA
4.35Single8IEPA1LYA8IEP-GPR156-A1LYA
4.35Single8IEPA1LYA8IEP-GPR156-A1LYA
4.35Single8INRAlpha-MSH8INR-MC5-α-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
4.35Single8K3ZCXCL128K3Z-CXCR4-CXCL12-Gi1/β1/γ1
4.35Single8KIGSHU91198KIG-MC3-SHU9119-Ca
4.35Single8WDTphotoNECA8WDT-A2A-photoNECA
4.35Single8ZBJSomatostatin-148ZBJ-SST5-Somatostatin-14-Gi1/β1/γ2
4.35Single8ZJDKisspeptin-108ZJD-Kiss1-Kisspeptin-10-chim(NtGi1-Gq)/β1/γ1
4.35Single9BKJCholecystokinin-89BKJ-CCKA-Cholecystokinin-8-chim(NtGi1-Gs-CtGq)/β1/γ2
4.35Single9BUYLM1899BUY-β2-LM189-Gi1/β1/γ2
4.35Single9HB3Mambaquaretin-19HB3-V2-Mambaquaretin-1
4.35Single9M4TSilodosin9M4T-Alpha1A-Silodosin
4.35Consensusclass-a_on_gpOrthosteric Ligandsensory_on_gp alicarboxylic_on_gp amine_on_gp lipid_on_gp nucleotide_on_gp peptide_on_gp protein_on_gp
4.35Consensuscxcr4_onOrthosteric Ligand8K3Z-CXCR4-CXCL12-Gi1/β1/γ1
4.35Consensusgi_opioidOrthosteric Ligand8F7R-μ-Endomorphin-Gi1/β1/γ2 8EF5-μ-Fentanyl-Gi1/β1/γ2 7SCG-μ-FH210-Gi1/β1/γ2 7T2H-μ-Lofentanil-Gi1/β1/γ2 7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2 8DZP-κ-momSalB-Gi1/β1/γ2 8EF6-μ-Morphine-Gi1/β1/γ2 8F7X-NOP-Nociceptin-Gi1/β1/γ2 8EFB-μ-Oliceridine-Gi1/β1/γ2 7U2L-μ-PubChem 163201242-Gi1/β1/γ2 8EFO-μ-PZM21-Gi1/β1/γ2 8EFL-μ-SR17018-Gi1/β1/γ2 8F7Q-μ-β-Endorphin-Gi1/β1/γ2 7U2K-μ-C6-guano-Gi1/β1/γ2 8EFQ-μ-Damgo-Gi1/β1/γ2 8F7S-δ-Deltorphin-Gi1/β1/γ2 8F7W-κ-Dynorphin-Gi1/β1/γ2
4.35Consensusgq_kisspeptinOrthosteric Ligand8ZJD-Kiss1-Kisspeptin-10-chim(NtGi1-Gq)/β1/γ1
4.35Consensuskiss1_on_gpOrthosteric Ligand8ZJD-Kiss1-Kisspeptin-10-chim(NtGi1-Gq)/β1/γ1
4.35Consensuskisspeptin_on_gpOrthosteric Ligandkiss1_on_gp
4.35Consensuslpl_onOrthosteric Ligands1p_on lpa_on
4.35Consensuslpl_on_gpOrthosteric Ligands1p_on_gp lpa_on_gp
4.35Consensusmop_offOrthosteric Ligand4DKL-μ-β-Funaltrexamine 8QOT-μ-Nanobody-E 7UL4-μ-Alvimopan
4.35Consensusnk3_onOrthosteric Ligand8JBF-NK3-Senktide-chim(NtGi1-Gs-CtGq)/β1/γ2
4.35Consensusnk3_on_gpOrthosteric Ligand8JBF-NK3-Senktide-chim(NtGi1-Gs-CtGq)/β1/γ2
4.35Consensusnmur1_on_gpOrthosteric Ligand7W53-NMUR1-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
4.35Consensusnop_onOrthosteric Ligand8F7X-NOP-Nociceptin-Gi1/β1/γ2
4.35Consensusnop_on_gpOrthosteric Ligand8F7X-NOP-Nociceptin-Gi1/β1/γ2
4.35Consensusp2y_onOrthosteric Ligandp2y1_on p2y10_on p2y12_on
4.17Single3QAKUK-4320973QAK-A2A-UK-432097
4.17Single6HLOAprepitant6HLO-NK1-Aprepitant
4.17Single7DDZJNJ-310200287DDZ-Y2-JNJ-31020028
4.17Single7EZKCholecystokinin-87EZK-CCKA-Cholecystokinin-8-chim(NtGi1-Gs)/β1/γ2
4.17Single7RMISubstance-P7RMI-NK1-Substance-P-chim(Gs-CtGq)/β1/γ2
4.17Single8F7QBeta-Endorphin8F7Q-μ-β-Endorphin-Gi1/β1/γ2
4.17Single8F7SDeltorphin8F7S-δ-Deltorphin-Gi1/β1/γ2
4.17Single8F7WDynorphin8F7W-κ-Dynorphin-Gi1/β1/γ2
4.17Single8IBVMotilin8IBV-Motilin-Motilin-chim(NtGi1-Gs-CtGq)/β1/γ2
4.17Single8IEBA1LYA8IEB-GPR156-A1LYA
4.17Single8JBHSubstance-P8JBH-NK3-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
4.17Single8WSSPro-MCH8WSS-MCH1-Pro-MCH-Gi1/β1/γ1
4.17Single9EAINanobody AT2099EAI-AT1-Losartan-Nanobody AT209
4.17Single9IQSMuscarinic toxin 39IQS-M4-Muscarinic toxin 3
4.17Single9IQVMuscarinic toxin 39IQV-Alpha1A-Muscarinic toxin 3
4.17Consensuscckb_onOrthosteric Ligand8IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/β1/γ2 7XOW-CCKB-Gastrin-chim(NtGi1-Gq)/β1/γ2 7F8V-CCKB-Gastrin-17-Gi2/β1/γ2
4.17Consensusccr8_on_gpOrthosteric Ligand8KFX-CCR8-LMD-009-Gi1/β1/γ2 8KFY-CCR8-ZK-756326-Gi1/β1/γ2 8U1U-CCR8-CCL1-Gi1/β1/γ2
4.17Consensuscompl-peptide_onOrthosteric Ligandc5a1_on c3a_on
4.17Consensusdop_on_gpOrthosteric Ligand8F7S-δ-Deltorphin-Gi1/β1/γ2
4.17Consensusgi_cckOrthosteric Ligand7EZH-CCKA-Cholecystokinin-8-Gi1/β1/γ2 7F8V-CCKB-Gastrin-17-Gi2/β1/γ2
4.17Consensusgi_ghrelinOrthosteric Ligand7NA7-Ghrelin-Ghrelin-27-Gi1/β1/γ2 7NA8-Ghrelin-PubChem 178024-Gi1/β1/γ2
4.17Consensusmc5_onOrthosteric Ligand8INR-MC5-α-MSH-Ca-chim(NtGi1-Gs)/β1/γ2 8IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/β1/γ2
4.17Consensusnpy2_offOrthosteric Ligand7DDZ-Y2-JNJ-31020028
4.17Consensuss1p3_on_gpOrthosteric Ligand7EW3-S1P3-S1P-Gi1/β1/γ2 7EW4-S1P3-CYM5541-Gi1/β1/γ2 7EW2-S1P3-Fingolimod-Gi1/β1/γ2
4.17Consensussst4_onOrthosteric Ligand7XMS-SST4-Somatostatin-14-Gi1/β1/γ2 7XMT-SST4-J-2156-Gi1/β1/γ2
4.17Consensussst4_on_gpOrthosteric Ligand7XMS-SST4-Somatostatin-14-Gi1/β1/γ2 7XMT-SST4-J-2156-Gi1/β1/γ2
4.17Consensustachykinin_on_gpOrthosteric Ligandnk1_on_gp nk2_on_gp nk3_on_gp
4.00Single5WF5UK-4320975WF5-A2A-UK-432097
4.00Single6MEOEnvelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd46MEO-CCR5-Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4
4.00Single6PT2KGCHM076PT2-δ-KGCHM07
4.00Single7F4DAlpha-MSH7F4D-MC1-α-MSH-chim(NtGi1-Gs)/β1/γ2
4.00Single7MBXCholecystokinin-87MBX-CCKA-Cholecystokinin-8-Gs/β1/γ1
4.00Single7O7F6P4-CCL57O7F-CCR5-6P4-CCL5-Gi1/β1/γ1
4.00Single7T6TfMLFII7T6T-FPR1-ALX-fMLFII-Gi1/β1/γ2
4.00Single7TD0LPA7TD0-LPA1-LPA-Gi1/β1/γ2
4.00Single7TD2LPA7TD2-LPA1-LPA-Gi1/β1/γ2
4.00Single7W55Neuromedin-U-257W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
4.00Single8XIQL7967788XIQ-SST3-L796778-chim(NtGi1-Gs-CtGi1)/β1/γ2
4.00Single8XIRPasireotide8XIR-SST3-Pasireotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
4.00Single9B54A1AIW9B54-CB1-A1AIW-Gi1/β1/γ2
4.00Single9M1OMorphine-Modulating Neuropeptide B9M1O-NPFF2-Morphine-Modulating Neuropeptide B-Gi1/β1/γ2
4.00Consensusc5a1_onOrthosteric Ligand8HK5-C5a1-Complement C5-Gi1/β1/γ2 7Y66-C5a1-BM213-Gi1/β1/γ2 7Y67-C5a1-C089 peptide-Gi1/β1/γ2 7Y64-C5a1-C5a anaphylatoxin-Gi1/β1/γ2
4.00Consensuscckb_on_gpOrthosteric Ligand8IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/β1/γ2 7XOW-CCKB-Gastrin-chim(NtGi1-Gq)/β1/γ2 7F8V-CCKB-Gastrin-17-Gi2/β1/γ2
4.00Consensuscompl-peptide_on_gpOrthosteric Ligandc5a1_on_gp c3a_on_gp
4.00Consensuscxcr4_on_gpOrthosteric Ligand8K3Z-CXCR4-CXCL12-Gi1/β1/γ1
4.00Consensusgi_somatostatinOrthosteric Ligand7WIC-SST2-Somatostatin-14-Gi1/β1/γ2 7XMS-SST4-Somatostatin-14-Gi1/β1/γ2 8X8L-SST5-Cortistatin-chim(NtGi1-Gs-CtGi1)/β1/γ2 7XMT-SST4-J-2156-Gi1/β1/γ2 7WIG-SST2-L-054,264-Gi1/β1/γ2 8X8N-SST5-Octreotide-chim(NtGi1-Gs-CtGi1)/β1/γ2 7YAE-SST2-Octreotide-Gi1/β1/γ2 7YAC-SST2-Paltusotine-Gi1/β1/γ2
4.00Consensusgs_cckOrthosteric Ligand7MBX-CCKA-Cholecystokinin-8-Gs/β1/γ1
4.00Consensusgs_class-aOrthosteric Ligandgs_peptide gs_nucleotide gs_amine
4.00Consensusnmur2_onOrthosteric Ligand7W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
4.00Consensusnmur2_on_gpOrthosteric Ligand7W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
4.00Consensuspeptide_offonOrthosteric Ligandpeptide_off peptide_on
4.00Consensussomatostatin_onOrthosteric Ligandsst2_on sst4_on sst5_on
4.00Consensussomatostatin_on_gpOrthosteric Ligandsst2_on_gp sst4_on_gp sst5_on_gp
3.85Single5WB2CX3CL1.355WB2-US28-CX3CL1.35
3.85Single6METEnvelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd46MET-CCR5-Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4
3.85Single6WIVPubChem 52923113; PubChem 529246456WIV-GABAB1, GABAB2-PubChem 52923113; PubChem 52924645
3.85Single7DW9AVP7DW9-V2-AVP-chim(NtGi1-Gs)/β1/γ2
3.85Single7F4HAfamelanotide7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2
3.85Single7T10Somatostatin-147T10-SST2-Somatostatin-14-Gi3/β1/γ2
3.85Single7W40Bombesin7W40-BB2-Bombesin-chim(NtGi1L-Gq)/β1/γ2
3.85Single7W57Neuromedin-S7W57-NMUR2-Neuromedin-S-chim(NtGi1-Gs-CtGq)/β1/γ2
3.85Single7WUIIP157WUI-ADGRG2-IP15-chim(NtGi1-Gs)/β1/γ2
3.85Single7YONPeptide-YY(3-36)7YON-Y2-Peptide-YY(3-36)-Gi1/β1/γ2
3.85Single8H4KGW95088H4K-FFA4-GW9508-chim(NtGi1-Gs-CtGq)/β1/γ2
3.85Single8IEDA1LYA8IED-GPR156-A1LYA-Go/β1/γ2
3.85Single8IEDA1LYA8IED-GPR156-A1LYA-Go/β1/γ2
3.85Single8WSTPro-MCH8WST-MCH2-Pro-MCH-chim(NtGi1L-Gs-CtGq)/β1/γ2
3.85Single8XWQEndothelin-18XWQ-ETB-Endothelin-1-Gi1/β1/γ2
3.85Single8ZBISomatostatin-148ZBI-SST3-Somatostatin-14-Gi1/β1/γ2
3.85Single9BKKCholecystokinin-89BKK-CCKA-Cholecystokinin-8-chim(NtGi1-Gs-CtGq)/β1/γ2
3.85Consensusc5a1_on_gpOrthosteric Ligand8HK5-C5a1-Complement C5-Gi1/β1/γ2 7Y66-C5a1-BM213-Gi1/β1/γ2 7Y67-C5a1-C089 peptide-Gi1/β1/γ2 7Y64-C5a1-C5a anaphylatoxin-Gi1/β1/γ2
3.85Consensusgi_class-aOrthosteric Ligandgi_peptide gi_sensory gi_alicarboxylic gi_amine gi_lipid gi_nucleotide gi_protein
3.85Consensusgs_vasop-oxyOrthosteric Ligand7DW9-V2-AVP-chim(NtGi1-Gs)/β1/γ2
3.85Consensusmc5_on_gpOrthosteric Ligand8INR-MC5-α-MSH-Ca-chim(NtGi1-Gs)/β1/γ2 8IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/β1/γ2
3.85Consensusneuromedin-u_onOrthosteric Ligandnmur1_on nmur2_on
3.85Consensuspeptide_offon_gpOrthosteric Ligandpeptide_on_gp peptide_off
3.85Consensustachykinin_onOrthosteric Ligandnk1_on nk2_on nk3_on
3.85Consensusv2_onOrthosteric Ligand7DW9-V2-AVP-chim(NtGi1-Gs)/β1/γ2
3.85Consensusv2_on_gpOrthosteric Ligand7DW9-V2-AVP-chim(NtGi1-Gs)/β1/γ2
3.85Consensusvasop-oxy_onOrthosteric Ligandv2_on
3.85Consensusvasop-oxy_on_gpOrthosteric Ligandv2_on_gp
3.70Single5YQZGlucagon analogue5YQZ-Glucagon-Glucagon analogue
3.70Single7F6HBradykinin7F6H-BK2-Bradykinin-Gq/β1/γ2
3.70Single7F6IKallidin7F6I-BK2-Kallidin-Gq/β1/γ2
3.70Single7F9YGhrelin-287F9Y-Ghrelin-Ghrelin-28-chim(NtGi1-Gs-CtGq)/β1/γ2
3.70Single7P02Protachykinin-17P02-NK1-Protachykinin-1-chim(NtGi1-Gs)/β1/γ2
3.70Single7Y64C5a anaphylatoxin7Y64-C5a1-C5a anaphylatoxin-Gi1/β1/γ2
3.70Single8HCXEndothelin-18HCX-ETB-Endothelin-1-chim(NtGi2L-Gs-CtGq)/β1/γ2
3.70Single8HK5Complement C58HK5-C5a1-Complement C5-Gi1/β1/γ2
3.70Single8IA2C5a anaphylatoxin8IA2-C5a1-C5a anaphylatoxin-Go/β1/γ2
3.70Single8WWKMCH8WWK-MCH1-MCH-Gi1/β1/γ2
3.70Single8XGOTAK4488XGO-Kiss1-TAK448-chim(NtGi1-Gq)/β1/γ2
3.70Single8XVHEndothelin-18XVH-ETB-Endothelin-1-chim(Gs-CtGq)/β1/γ2
3.70Single8XVIEndothelin-18XVI-ETA-Endothelin-1-chim(Gs-CtGq)/β1/γ2
3.70Single8ZRTET-18ZRT-ETB-ET-1
3.70Single9JFYhNPSF9JFY-NPFF2-hNPSF-Gi1/β1/γ2
3.70Consensusmc1_onOrthosteric Ligand7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2 7F4D-MC1-α-MSH-chim(NtGi1-Gs)/β1/γ2 7F4I-MC1-SHU9119-chim(NtGi1-Gs)/β1/γ2
3.70Consensusmc1_on_gpOrthosteric Ligand7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2 7F4D-MC1-α-MSH-chim(NtGi1-Gs)/β1/γ2 7F4I-MC1-SHU9119-chim(NtGi1-Gs)/β1/γ2
3.70Consensusneuromedin-u_on_gpOrthosteric Ligandnmur1_on_gp nmur2_on_gp
3.70Consensusopioid_onOrthosteric Ligandmop_on nop_on dop_on kop_on
3.70Consensusp2y10_onOrthosteric Ligand8KGG-P2Y10-LPS-chim(NtGi2-G13)/β1/γ2
3.70Consensussst5_on_gpOrthosteric Ligand8X8L-SST5-Cortistatin-chim(NtGi1-Gs-CtGi1)/β1/γ2 8X8N-SST5-Octreotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
3.57Single5UIW5P7-CCL55UIW-CCR5-5P7-CCL5
3.57Single7F8VGastrin-177F8V-CCKB-Gastrin-17-Gi2/β1/γ2
3.57Single7W3ZGastrin Releasing Peptide7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/β1/γ2
3.57Single8H0PNMB308H0P-BB1-NMB30-chim(NtGi1-Gs-CtGq)/β1/γ2
3.57Single8XQFApelin-138XQF-Apelin-Apelin-13-Gi1/β1/γ2
3.57Single8XVEBQ30208XVE-ETB-BQ3020-chim(Gs-CtGq)/β1/γ2
3.57Consensusccr5_offOrthosteric Ligand5UIW-CCR5-5P7-CCL5
3.57Consensusccr5_onOrthosteric Ligand7O7F-CCR5-6P4-CCL5-Gi1/β1/γ1 7F1Q-CCR5-MIP-1a-Gi1/β1/γ2
3.57Consensusctlike_onOrthosteric Ligand6E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/β1/γ2; RAMP1
3.57Consensusgi_compl-peptOrthosteric Ligand8HK5-C5a1-Complement C5-Gi1/β1/γ2 8IA8-C3aB-E7 peptide-Gi1/β1/γ2 7Y66-C5a1-BM213-Gi1/β1/γ2 7Y67-C5a1-C089 peptide-Gi1/β1/γ2 8HK2-C3aB-C3a anaphylatoxin-Gi1/β1/γ2 7Y64-C5a1-C5a anaphylatoxin-Gi1/β1/γ2
3.57Consensusgi_peptideOrthosteric Ligandgi_cck gi_apelin gi_compl-pept gi_endothelin gi_formylpeptide gi_galanin gi_ghrelin gi_npy gi_neurotensin gi_opioid gi_orexin gi_relaxin gi_somatostatin
3.57Consensusopioid_on_gpOrthosteric Ligandmop_on_gp nop_on_gp dop_on_gp kop_on_gp
3.45Single7F4FAfamelanotide7F4F-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2
3.45Single7XATSomatostatin-147XAT-SST2-Somatostatin-14-Gi1/β1/γ2
3.45Single8FEG(DNCP)-Beta-Naloxamine8FEG-κ-(DNCP)-β-Naloxamine-Gi1/β1/γ2
3.45Single8W8XBeta-MSH8W8X-MC3-β-MSH-Ca-Gs/β1/γ2
3.45Single8WWLMCH8WWL-MCH1-MCH-Gi1/β1/γ2
3.45Single8XWPEndothelin-18XWP-ETB-Endothelin-1-Gi1/β1/γ2
3.45Single9KDFRES-701-39KDF-ETB-RES-701-3
3.45Consensusgq_peptideOrthosteric Ligandgq_cck gq_kisspeptin gq_bradykinin gq_bombesin gq_angiotensin
3.45Consensuspeptide_onOrthosteric Ligandcck_on angiotensin_on apelin_on bombesin_on bradykinin_on compl-peptide_on endothelin_on formylpeptide_on galanin_on ghrelin_on kisspeptin_on melanocortin_on motilin_on neuromedin-u_on npy_on neurotensin_on opioid_on orexin_on relaxin_on somatostatin_on tachykinin_on trh_on vasop-oxy_on
3.45Consensuspeptide_on_gpOrthosteric Ligandcck_on_gp angiotensin_on_gp apelin_on_gp bombesin_on_gp bradykinin_on_gp compl-peptide_on_gp endothelin_on_gp formylpeptide_on_gp galanin_on_gp ghrelin_on_gp kisspeptin_on_gp melanocortin_on_gp motilin_on_gp neuromedin-u_on_gp npy_on_gp neurotensin_on_gp opioid_on_gp orexin_on_gp relaxin_on_gp somatostatin_on_gp tachykinin_on_gp trh_on_gp vasop-oxy_on_gp
3.33Single6IGLIRL16206IGL-ETB-IRL1620
3.33Single8IY5Endothelin-18IY5-ETB-Endothelin-1-Gi1/β1/γ2
3.33Single8IY6Endothelin-18IY6-ETB-Endothelin-1
3.33Single8WWNMCH8WWN-MCH1-MCH-Gi1/β1/γ2
3.33Single8Y52BA18Y52-BB3-BA1-chim(NtGi1-Gs-CtGq)/β1/γ2
3.33Consensusbk2_onOrthosteric Ligand7F6H-BK2-Bradykinin-Gq/β1/γ2 7F6I-BK2-Kallidin-Gq/β1/γ2
3.33Consensusbk2_on_gpOrthosteric Ligand7F6H-BK2-Bradykinin-Gq/β1/γ2 7F6I-BK2-Kallidin-Gq/β1/γ2
3.33Consensusbradykinin_onOrthosteric Ligandbk2_on
3.33Consensusbradykinin_on_gpOrthosteric Ligandbk2_on_gp
3.33Consensusctlike_on_gpOrthosteric Ligand6E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/β1/γ2; RAMP1
3.33Consensusendothelin_onOrthosteric Ligandetb_on eta_on
3.33Consensusetb_onOrthosteric Ligand8IY5-ETB-Endothelin-1-Gi1/β1/γ2 8HBD-ETB-IRL1620-Gi1/β1/γ2
3.33Consensusgq_bradykininOrthosteric Ligand7F6H-BK2-Bradykinin-Gq/β1/γ2 7F6I-BK2-Kallidin-Gq/β1/γ2
3.23Single5GLHEndothelin-15GLH-ETB-Endothelin-1
3.23Single6IGKEndothelin-36IGK-ETB-Endothelin-3
3.23Single8U1UCCL18U1U-CCR8-CCL1-Gi1/β1/γ2
3.23Single8ZJETAK-4488ZJE-Kiss1-TAK-448-chim(NtGi1-Gq)/β1/γ1
3.23Consensusbb2_onOrthosteric Ligand7W40-BB2-Bombesin-chim(NtGi1L-Gq)/β1/γ2 7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/β1/γ2
3.23Consensusbb2_on_gpOrthosteric Ligand7W40-BB2-Bombesin-chim(NtGi1L-Gq)/β1/γ2 7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/β1/γ2
3.23Consensusbombesin_onOrthosteric Ligandbb2_on
3.23Consensusbombesin_on_gpOrthosteric Ligandbb2_on_gp
3.23Consensusccr5_on_gpOrthosteric Ligand7O7F-CCR5-6P4-CCL5-Gi1/β1/γ1 7F1Q-CCR5-MIP-1a-Gi1/β1/γ2
3.23Consensusgi_endothelinOrthosteric Ligand8IY5-ETB-Endothelin-1-Gi1/β1/γ2 8HBD-ETB-IRL1620-Gi1/β1/γ2
3.23Consensusgq_bombesinOrthosteric Ligand7W40-BB2-Bombesin-chim(NtGi1L-Gq)/β1/γ2 7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/β1/γ2
3.12Single8HBDIRL16208HBD-ETB-IRL1620-Gi1/β1/γ2
3.12Consensusendothelin_on_gpOrthosteric Ligandetb_on_gp eta_on_gp
3.12Consensusetb_on_gpOrthosteric Ligand8IY5-ETB-Endothelin-1-Gi1/β1/γ2 8HBD-ETB-IRL1620-Gi1/β1/γ2
3.03Single6LRYSarafotoxin-B6LRY-ETB-Sarafotoxin-B

PDB Summary
PDB 7Y12
Class A
SubFamily Orphan
Type Orphan
SubType MRGPRD
Species Homo Sapiens
Ligand Beta-Alanine
Other Ligand(s) -
Protein Partners Gi1/Beta1/Gamma2
PDB Resolution 3.1
Date 2022-07-20
D.O.I. doi.org/10.1038/s42003-022-03668-3
Net Summary
Imin 3.44
Number of Linked Nodes 829
Number of Links 956
Number of Hubs 122
Number of Links mediated by Hubs 492
Number of Communities 26
Number of Nodes involved in Communities 194
Number of Links involved in Communities 263
Path Summary
Number Of Nodes in MetaPath 117
Number Of Links MetaPath 116
Number of Shortest Paths 810797
Length Of Smallest Path 3
Average Path Length 33.1386
Length of Longest Path 73
Minimum Path Strength 1.25
Average Path Strength 6.96817
Maximum Path Strength 33.725
Minimum Path Correlation 0.71
Average Path Correlation 0.977959
Maximum Path Correlation 1
Minimum % Of Corr. Nodes 2.12766
Average % Of Corr. Nodes 46.1096
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 42.4589
Maximum Path Hubs % 100
AnnotationTypeLinks
Gene OntologyMolecular Function
Gene OntologyBiological Process
Gene OntologyCellular Component
SCOP2Domain Identifier• Transducin (heterotrimeric G protein), gamma chain   • WD40 repeat-like   • Ras-like P-loop GTPases
SCOP2Family Identifier• Transducin (heterotrimeric G protein), gamma chain   • WD40 repeat-like   • Ras-like P-loop GTPases
Membrane Protein Annotations-• Orientations of Proteins in Membranes database (OPM)   • Protein Data Bank of Transmembrane Proteins (PDBTM)   • MemProtMD


Details about the values in these tables can be found in the corresponding documentation page .
CodeBAL
PDB ResiduesL:L:?1
Environment DetailsOpen EMBL-EBI Page
CodeBAL
Namebeta-Alanine
Synonymsω-aminopropionic acid
Identifier
FormulaC3 H7 N O2
Molecular Weight89.093
SMILES
PubChem4755801
Formal Charge0
Total Atoms13
Total Chiral Atoms0
Total Bonds12
Total Aromatic Bonds0

PDBsumOpen PDBsum Page
ChainA
ProteinG Protein α Sub unit
UniProtP63096
Sequence
>7Y12_Chain_A
CTLSAEDKA AVERSKMID RNLREDGEK AAREVKLLL LGAGESGKS 
TIVKQMKTG IVETHFTFK DLHFKMFDV GAQRSERKK WIHCFEGVA 
AIIFCVALS DYDLMNRMH ESMKLFDSI CNNKWFTDT SIILFLNKK 
DLFEEKIKK SPLTICYQE YAGSNTYEE AAAYIQCQF EDLNKRKDT 
KEIYTHFTC STDTKNVQF VFDAVTDVI IKNNLKDCG LF


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainB
ProteinG Protein β Sub unit
UniProtP62874
Sequence
>7Y12_Chain_B
ELDQLRQEA EQLKNQIRD ARKACADAT LSQITNNID PVGRIQMRT 
RRTLRGHLA KIYAMHWGT DSRLLVSAS QDGKLIIWD SYTTNKVHA 
IPLRSSWVM TCAYAPSGN YVACGGLDN ICSIYNLKT REGNVRVSR 
ELAGHTGYL SCCRFLDDN QIVTSSGDT TCALWDIET GQQTTTFTG 
HTGDVMSLS LAPDTRLFV SGACDASAK LWDVREGMC RQTFTGHES 
DINAICFFP NGNAFATGS DDATCRLFD LRADQELMT YSHDNIICG 
ITSVSFSKS GRLLLAGYD DFNCNVWDA LKADRAGVL AGHDNRVSC 
LGVTDDGMA VATGSWDSF LKIWN


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainG
ProteinG Protein γ Sub unit
UniProtP63213
Sequence
>7Y12_Chain_G
ASIAQARKL VEQLKMEAN IDRIKVSKA AADLMAYCE AHAKEDPLL 
TPVPASENP FRE


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainR
ProteinReceptor
UniProtQ8TDS7
Sequence
>7Y12_Chain_R
TVHTAYLVL SSLAMFTCL CGMAGNSMV IWLLGFRMH RNPFCIYIL 
NLAAADLLF LFSMASTLS LETQPLVNT TDKVHELMK RLMYFAYTV 
GLSLLTAIS TQRCLSVLF PIWFKCHRP RHLSAWVCG LLWTLCLLM 
NGLTSSFCS KFLKFNEDR CFRVDMVQA ALIMGVLTP VMTLSSLTL 
FVWVRRSSQ QWRRQPTRL FVVVLASVL VFLICSLPL SIYWFVLYW 
LSLPPEMQV LCFSLSRLS SSVSSSANP VIYFLVGSR RSH


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  




This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
9DQHAOrphanOrphanMRGPRDHomo sapiensEP-2825-chim(NtGi1-Gs-CtGq)/β1/γ22.922024-12-11doi.org/10.1016/j.celrep.2024.114942
9DQH (No Gprot) AOrphanOrphanMRGPRDHomo sapiensEP-2825-2.922024-12-11doi.org/10.1016/j.celrep.2024.114942
9DQJAOrphanOrphanMRGPRDHomo sapiensEP-3945-chim(NtGi1-Gs-CtGq)/β1/γ22.92024-12-11doi.org/10.1016/j.celrep.2024.114942
9DQJ (No Gprot) AOrphanOrphanMRGPRDHomo sapiensEP-3945-2.92024-12-11doi.org/10.1016/j.celrep.2024.114942
7Y12AOrphanOrphanMRGPRDHomo sapiensβ-Alanine-Gi1/β1/γ23.12022-07-20doi.org/10.1038/s42003-022-03668-3
7Y12 (No Gprot) AOrphanOrphanMRGPRDHomo sapiensβ-Alanine-3.12022-07-20doi.org/10.1038/s42003-022-03668-3
7Y13AOrphanOrphanMRGPRDHomo sapiens---3.12022-07-20doi.org/10.1038/s42003-022-03668-3
7Y14AOrphanOrphanMRGPRDHomo sapiensβ-Alanine--3.22022-07-20doi.org/10.1038/s42003-022-03668-3
7Y15AOrphanOrphanMRGPRDHomo sapiens--Gi1/β1/γ22.92022-07-20doi.org/10.1038/s42003-022-03668-3
7Y15 (No Gprot) AOrphanOrphanMRGPRDHomo sapiens--2.92022-07-20doi.org/10.1038/s42003-022-03668-3




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Download 7Y12.zip



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