Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg Int. Strength Num Of Links Community ConSurf
1A:A:V34 5.444135
2A:A:I184 7.1275419
3A:A:L194 5.5354134
4A:A:F196 9.2845137
5A:A:K197 12.98416
6A:A:M198 4.5507
7A:A:F199 8.156515
8A:A:Q204 6.5675419
9A:A:S206 5.0625418
10A:A:R208 5.865409
11A:A:K210 6.858519
12A:A:W211 6.97667619
13A:A:F215 9.575419
14A:A:Y230 11.8554198
15A:A:F250 6.32857709
16A:A:W258 7.30714745
17A:A:F259 6.814509
18A:A:I265 3.672508
19A:A:F267 6.33754149
20A:A:F274 6.405409
21A:A:L283 5.99407
22A:A:Y287 5.015407
23A:A:Y290 7.08507
24A:A:Y320 5.8275407
25A:A:F323 5.8494
26A:A:T324 5.99254149
27A:A:F336 7.835408
28A:A:C351 5.515434
29A:A:L353 6.7875437
30B:B:L4 3.395404
31B:B:V40 5.46683
32B:B:H54 10.23529
33B:B:Y59 9.0675448
34B:B:W63 6.02286727
35B:B:D76 6.63429
36B:B:I80 8.9925428
37B:B:W82 9.38428729
38B:B:N88 6.29407
39B:B:K89 8.588529
40B:B:H91 5.6325405
41B:B:I93 4.7175407
42B:B:L95 5.8875408
43B:B:W99 9.22857719
44B:B:Y105 4.788577206
45B:B:N110 6.9254154
46B:B:Y111 7.0485154
47B:B:L117 5.96419
48B:B:Y124 5.64167606
49B:B:L126 4.934205
50B:B:L139 7.296509
51B:B:H142 7.968519
52B:B:Y145 6.1475818
53B:B:F151 4.86333609
54B:B:T159 6.43519
55B:B:D163 7.975419
56B:B:W169 10.848518
57B:B:F180 9.6525467
58B:B:H183 10.9625469
59B:B:D186 6.6925419
60B:B:F199 8.58469
61B:B:V200 6.86456
62B:B:D205 7.33469
63B:B:K209 12.8825466
64B:B:L210 5.9075405
65B:B:W211 9.996568
66B:B:R219 7.1954105
67B:B:Q220 8.55457
68B:B:F222 9.152558
69B:B:H225 9.746559
70B:B:D228 6.714519
71B:B:I232 5.095458
72B:B:F235 8.55116
73B:B:P236 6.0154117
74B:B:F241 8.8556
75B:B:T243 6.3175458
76B:B:R251 14.5458
77B:B:F253 9.8075456
78B:B:D254 5.125409
79B:B:D258 10.5457
80B:B:Q259 4.5406
81B:B:E260 7.6375456
82B:B:Y264 6.224505
83B:B:F278 5.843336117
84B:B:R283 9.146589
85B:B:L284 5.0625485
86B:B:L285 5.21406
87B:B:Y289 7.15714747
88B:B:D290 9.7925446
89B:B:C294 5.09475
90B:B:N295 7.265446
91B:B:W297 6.7475448
92B:B:K301 5.6825405
93B:B:R304 10.4545
94B:B:H311 8.884579
95B:B:R314 12.995448
96B:B:V315 4.8525477
97B:B:T329 5.72408
98B:B:W332 11.9386749
99B:B:D333 6.8325479
100B:B:L336 6.0375427
101B:B:K337 7.8675476
102B:B:W339 12.018579
103G:G:V16 4.7425407
104G:G:Y40 9.0954116
105G:G:D48 6.5545219
106G:G:N59 7.0775409
107G:G:P60 7.52429
108G:G:F61 5.28628
109R:R:L52 5.695408
110R:R:M56 4.44407
111R:R:N59 6.6725438
112R:R:P60 5.19437
113R:R:F61 6.84857738
114R:R:Y64 7.39608
115R:R:L68 5.1525439
116R:R:D72 7.3439
117R:R:F75 5.81754126
118R:R:E99 7.664175
119R:R:K102 4.48254173
120R:R:R103 6.00754174
121R:R:Y109 6.896676128
122R:R:Q122 9.245439
123R:R:S126 5.9725438
124R:R:F133 7.51833637
125R:R:R137 6.51833639
126R:R:W150 7.2975409
127R:R:K166 9.25403
128R:R:T191 4.075405
129R:R:F220 7.83754245
130R:R:V222 2.675437
131R:R:L237 6.3954125
132R:R:S238 3.31407
133R:R:Y240 8.6175403
134R:R:Y245 4.6154234
135R:R:L256 2.2625402
136R:R:R262 9.065404
137R:R:S268 4.415409
138R:R:N272 6.422539
139R:R:Y276 6.198539
140R:R:F277 4.7075407
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
1B:B:D66 B:B:R68 36.04684.76NoNo085
2B:B:D66 B:B:L69 36.23936.79NoNo085
3B:B:L69 B:B:Y105 36.31757.03NoYes056
4B:B:V112 B:B:Y105 36.77655.05NoYes2086
5B:B:V112 B:B:Y124 37.50973.79NoYes086
6B:B:C114 B:B:Y124 41.25436.72NoYes086
7B:B:C114 B:B:G115 43.42123.92NoNo089
8B:B:G115 B:B:L146 43.65413.42NoNo097
9B:B:H142 B:B:L146 28.32683.86YesNo197
10B:B:H142 B:B:S161 98.892513.95YesNo199
11B:B:G162 B:B:S161 1003.71NoNo199
12B:B:G162 B:B:Y145 99.73034.35NoYes198
13A:A:W211 B:B:Y145 88.0715.79YesYes198
14A:A:R208 A:A:W211 82.27917YesYes099
15A:A:I212 A:A:R208 70.15645.01NoYes089
16A:A:F259 A:A:I212 70.08885.02YesNo098
17A:A:F259 A:A:T262 85.24959.08YesNo097
18A:A:D261 A:A:T262 85.13944.34NoNo047
19A:A:D261 A:A:K349 85.02884.15NoNo045
20A:A:K349 R:R:R282 84.80637.43NoNo055
21A:A:D350 R:R:R282 84.69449.53NoNo045
22A:A:D350 R:R:F61 75.59264.78NoYes348
23R:R:F61 R:R:Q122 13.382214.05YesYes389
24B:B:R68 B:B:Y85 32.9826.75NoNo054
25B:B:Y85 G:G:F61 23.24457.22NoYes248
26B:B:S84 G:G:F61 11.30775.28NoYes058
27B:B:S84 B:B:W63 11.03584.94NoYes057
28B:B:L70 B:B:W63 18.768410.25NoYes257
29B:B:L70 B:B:W82 18.25473.42NoYes259
30B:B:I338 G:G:F61 11.30725.02NoYes258
31B:B:I338 B:B:W63 11.05714.7NoYes257
32A:A:Q204 B:B:Y145 13.05256.76YesYes198
33A:A:Q204 B:B:L117 13.07335.32YesYes199
34B:B:L117 B:B:W99 31.81095.69YesYes199
35A:A:W211 B:B:L117 20.03285.69YesYes199
36A:A:L249 A:A:R208 47.43874.86NoYes099
37A:A:F223 A:A:L249 47.22487.31NoNo099
38A:A:F223 A:A:F250 46.5813.93NoYes099
39A:A:F250 A:A:L266 40.82446.09YesNo099
40A:A:L266 A:A:L268 39.84486.92NoNo098
41A:A:L227 A:A:L268 39.09168.3NoNo978
42A:A:F274 A:A:L227 39.0267.31YesNo097
43A:A:F274 A:A:Y296 30.17954.13YesNo094
44A:A:K271 A:A:Y296 29.68415.97NoNo054
45A:A:C325 A:A:K271 29.43573.23NoNo075
46A:A:C325 A:A:D328 28.93756.22NoNo079
47A:A:D328 A:A:T324 15.02685.78NoYes1499
48A:A:F267 A:A:T324 13.45276.49YesYes1499
49A:A:F267 A:A:I265 18.11143.77YesYes098
50A:A:I265 A:A:V335 11.01233.07YesNo088
51A:A:I222 A:A:V335 10.46613.07NoNo078
52A:A:D328 A:A:N331 13.66074.04NoNo1498
53A:A:F267 A:A:N331 13.39846.04YesNo1498
54A:A:F215 A:A:L37 17.27615.83YesNo099
55A:A:F215 B:B:W99 15.407111.02YesYes199
56A:A:F259 A:A:L37 16.42993.65YesNo099
57B:B:W297 B:B:Y264 19.76025.79YesYes085
58B:B:W297 B:B:Y289 20.45918.68YesYes487
59B:B:C271 B:B:Y289 23.4554.03NoYes457
60B:B:C271 B:B:D290 35.04126.22NoYes456
61B:B:D290 B:B:R314 35.835623.82YesYes468
62B:B:Q75 B:B:W99 40.40838.76NoYes099
63B:B:Q75 B:B:Y59 40.07515.78NoYes098
64B:B:W332 B:B:Y59 38.83776.75YesYes498
65B:B:R314 B:B:W332 36.155618.99YesYes489
66A:A:F274 A:A:Y230 10.10534.13YesYes098
67A:A:C351 R:R:F61 55.1188.38YesYes348
68A:A:C351 R:R:R123 50.22656.96YesNo349
69B:B:L146 B:B:T159 15.56378.84NoYes179
70B:B:C149 B:B:T159 74.21523.38NoYes189
71B:B:C149 B:B:T102 75.50875.07NoNo088
72B:B:C148 B:B:T102 75.31343.38NoNo068
73B:B:C148 B:B:S160 74.92173.44NoNo066
74B:B:S160 B:B:V187 74.52814.85NoNo069
75B:B:C166 B:B:V187 74.33073.42NoNo089
76B:B:C166 B:B:F199 70.7414.19NoYes089
77B:B:F199 B:B:V158 33.72475.24YesNo095
78B:B:L192 B:B:V158 33.48764.47NoNo055
79B:B:L152 B:B:L192 33.25086.92NoNo035
80B:B:L152 B:B:Q156 32.7779.32NoNo035
81B:B:Q156 B:B:R214 32.30283.5NoNo059
82B:B:R197 B:B:R214 64.448511.73NoNo059
83B:B:D195 B:B:R197 63.9473.57NoNo055
84B:B:D195 B:B:P194 62.94283.22NoNo054
85B:B:F234 B:B:P194 61.93684.33NoNo054
86B:B:F234 B:B:V200 60.9297.87NoYes056
87B:B:L210 B:B:V200 26.53884.47YesYes056
88B:B:L210 B:B:Q220 22.34195.32YesYes057
89B:B:D258 B:B:Q220 21.281216.97YesYes577
90B:B:D258 B:B:R22 39.51810.72YesNo076
91B:B:I18 B:B:R22 24.63656.26NoNo076
92B:B:I18 G:G:A23 23.57023.25NoNo078
93B:B:L14 G:G:A23 20.36871.58NoNo088
94B:B:L14 G:G:K20 17.16327.05NoNo086
95G:G:K20 G:G:V16 16.09381.52NoYes067
96B:B:L7 G:G:V16 12.8831.49NoYes087
97B:B:F180 B:B:F199 33.706112.86YesYes679
98B:B:F180 B:B:T178 33.6045.19YesNo074
99B:B:L168 B:B:T178 33.36734.42NoNo064
100B:B:L168 B:B:V213 32.8944.47NoNo064
101B:B:R214 B:B:V213 32.65716.54NoNo094
102B:B:F241 B:B:V200 27.047410.49YesYes566
103B:B:F222 B:B:F241 21.770512.86YesYes586
104B:B:D258 B:B:F222 21.41414.78YesYes578
105B:B:Q259 B:B:R22 13.95374.67YesNo066
106B:B:C25 B:B:Q259 10.74023.05NoYes036
107B:B:D291 B:B:N293 12.42346.73NoNo085
108B:B:A309 B:B:N293 12.06534.69NoNo035
109B:B:A309 B:B:G310 11.70681.95NoNo035
110B:B:G310 B:B:W339 11.34782.81NoYes059
111B:B:L285 B:B:Y264 10.94854.69YesYes065
112R:R:R123 R:R:Y276 51.34577.2NoYes399
113R:R:N272 R:R:Y276 52.39895.81YesYes399
114R:R:D72 R:R:N272 32.86236.73YesYes399
115R:R:D72 R:R:S269 32.569810.31YesNo099
116R:R:F75 R:R:S269 31.37327.93YesNo069
117R:R:F75 R:R:M105 10.09636.22YesNo064
118R:R:Q122 R:R:Y64 10.408712.4YesYes098
119R:R:F75 R:R:Y109 18.88435.16YesYes1268
120R:R:N272 R:R:S268 19.22824.47YesYes099
121R:R:S234 R:R:S268 18.37646.52NoYes079
122R:R:L113 R:R:S234 18.17434.5NoNo087
123R:R:L113 R:R:Y109 17.975114.07NoYes088
124R:R:W241 R:R:Y109 10.16273.86NoYes1248
125R:R:S238 R:R:Y109 20.05253.82YesYes078
126R:R:M187 R:R:S238 14.1053.07NoYes077
127R:R:M187 R:R:T191 13.14423.01NoYes075
128R:R:F230 R:R:T191 11.21733.89NoYes095
129R:R:L237 R:R:S261 10.11534.5YesNo055
130B:B:H142 B:B:T159 70.91936.85YesYes199
131B:B:C271 B:B:D291 11.30757.78NoNo458
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


PDB Summary
PDB 7Y15
Class A
SubFamily Orphan
Type Orphan
SubType MRGPRD
Species Homo Sapiens
Ligand -
Other Ligand(s) -
Protein Partners Gi1/Beta1/Gamma2
PDB Resolution 2.9
Date 2022-07-20
D.O.I. doi.org/10.1038/s42003-022-03668-3
Net Summary
Imin 3.38
Number of Linked Nodes 822
Number of Links 962
Number of Hubs 140
Number of Links mediated by Hubs 512
Number of Communities 24
Number of Nodes involved in Communities 191
Number of Links involved in Communities 268
Path Summary
Number Of Nodes in MetaPath 132
Number Of Links MetaPath 131
Number of Shortest Paths 862949
Length Of Smallest Path 3
Average Path Length 32.0386
Length of Longest Path 65
Minimum Path Strength 1.215
Average Path Strength 6.79205
Maximum Path Strength 23.5533
Minimum Path Correlation 0.7
Average Path Correlation 0.977712
Maximum Path Correlation 1
Minimum % Of Corr. Nodes 4.34783
Average % Of Corr. Nodes 44.4087
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 39.7199
Maximum Path Hubs % 100
AnnotationTypeLinks
Gene OntologyMolecular Function
Gene OntologyBiological Process
Gene OntologyCellular Component
SCOP2Domain Identifier• Transducin (heterotrimeric G protein), gamma chain   • WD40 repeat-like   • Ras-like P-loop GTPases
SCOP2Family Identifier• Transducin (heterotrimeric G protein), gamma chain   • WD40 repeat-like   • Ras-like P-loop GTPases
Membrane Protein Annotations-• Orientations of Proteins in Membranes database (OPM)   • Protein Data Bank of Transmembrane Proteins (PDBTM)   • MemProtMD


Details about the values in these tables can be found in the corresponding documentation page .
PDBsumOpen PDBsum Page
ChainA
ProteinG Protein α Sub unit
UniProtP63096
Sequence
>7Y15_Chain_A
CTLSAEDKA AVERSKMID RNLREDGEK AAREVKLLL LGAGESGKS 
TIVKQMKTG IVETHFTFK DLHFKMFDV GAQRSERKK WIHCFEGVA 
AIIFCVALS DYDLMNRMH ESMKLFDSI CNNKWFTDT SIILFLNKK 
DLFEEKIKK SPLTICYQE YAGSNTYEE AAAYIQCQF EDLNKRKDT 
KEIYTHFTC STDTKNVQF VFDAVTDVI IKNNLKDCG LF


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainB
ProteinG Protein β Sub unit
UniProtP62874
Sequence
>7Y15_Chain_B
ELDQLRQEA EQLKNQIRD ARKACADAT LSQITNNID PVGRIQMRT 
RRTLRGHLA KIYAMHWGT DSRLLVSAS QDGKLIIWD SYTTNKVHA 
IPLRSSWVM TCAYAPSGN YVACGGLDN ICSIYNLKT REGNVRVSR 
ELAGHTGYL SCCRFLDDN QIVTSSGDT TCALWDIET GQQTTTFTG 
HTGDVMSLS LAPDTRLFV SGACDASAK LWDVREGMC RQTFTGHES 
DINAICFFP NGNAFATGS DDATCRLFD LRADQELMT YSHDNIICG 
ITSVSFSKS GRLLLAGYD DFNCNVWDA LKADRAGVL AGHDNRVSC 
LGVTDDGMA VATGSWDSF LKIWN


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainG
ProteinG Protein γ Sub unit
UniProtP63213
Sequence
>7Y15_Chain_G
ASIAQARKL VEQLKMEAN IDRIKVSKA AADLMAYCE AHAKEDPLL 
TPVPASENP FRE


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainR
ProteinReceptor
UniProtQ8TDS7
Sequence
>7Y15_Chain_R
TVHTAYLVL SSLAMFTCL CGMAGNSMV IWLLGFRMH RNPFCIYIL 
NLAAADLLF LFSMASTLS LETQPLVNT TDKVHELMK RLMYFAYTV 
GLSLLTAIS TQRCLSVLF PIWFKCHRP RHLSAWVCG LLWTLCLLM 
NGLTSSFCS KFLKFNEDR CFRVDMVQA ALIMGVLTP VMTLSSLTL 
FVWVRRSSQ QWRRQPTRL FVVVLASVL VFLICSLPL SIYWFVLYW 
LSLPPEMQV LCFSLSRLS SSVSSSANP VIYFLVGSR RSH


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  




This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
9DQHAOrphanOrphanMRGPRDHomo sapiensEP-2825-chim(NtGi1-Gs-CtGq)/β1/γ22.922024-12-11doi.org/10.1016/j.celrep.2024.114942
9DQH (No Gprot) AOrphanOrphanMRGPRDHomo sapiensEP-2825-2.922024-12-11doi.org/10.1016/j.celrep.2024.114942
9DQJAOrphanOrphanMRGPRDHomo sapiensEP-3945-chim(NtGi1-Gs-CtGq)/β1/γ22.92024-12-11doi.org/10.1016/j.celrep.2024.114942
9DQJ (No Gprot) AOrphanOrphanMRGPRDHomo sapiensEP-3945-2.92024-12-11doi.org/10.1016/j.celrep.2024.114942
7Y12AOrphanOrphanMRGPRDHomo sapiensβ-Alanine-Gi1/β1/γ23.12022-07-20doi.org/10.1038/s42003-022-03668-3
7Y12 (No Gprot) AOrphanOrphanMRGPRDHomo sapiensβ-Alanine-3.12022-07-20doi.org/10.1038/s42003-022-03668-3
7Y13AOrphanOrphanMRGPRDHomo sapiens---3.12022-07-20doi.org/10.1038/s42003-022-03668-3
7Y14AOrphanOrphanMRGPRDHomo sapiensβ-Alanine--3.22022-07-20doi.org/10.1038/s42003-022-03668-3
7Y15AOrphanOrphanMRGPRDHomo sapiens--Gi1/β1/γ22.92022-07-20doi.org/10.1038/s42003-022-03668-3
7Y15 (No Gprot) AOrphanOrphanMRGPRDHomo sapiens--2.92022-07-20doi.org/10.1038/s42003-022-03668-3




You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download 7Y15.zip



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