Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg Int. Strength Num Of Links Community ConSurf
1A:A:L5 4.25754212
2A:A:V34 5.44485
3A:A:K46 6.1154229
4A:A:I184 6.522519
5A:A:F189 6.4325409
6A:A:F191 10.27485
7A:A:L194 5.535484
8A:A:F196 9.284587
9A:A:M198 4.5507
10A:A:F199 9.322515
11A:A:Q204 6.31519
12A:A:S206 5.0625418
13A:A:E207 7.49419
14A:A:R208 5.865409
15A:A:K209 7.9525418
16A:A:K210 6.6819
17A:A:W211 6.97667619
18A:A:F215 9.575419
19A:A:Y230 11.8554128
20A:A:D231 8.70254129
21A:A:F250 6.328577109
22A:A:D251 7.54105
23A:A:C254 4.355105
24A:A:W258 7.945665
25A:A:F259 6.814509
26A:A:I265 3.672508
27A:A:F267 6.33754169
28A:A:F274 6.405409
29A:A:L283 5.99407
30A:A:Y287 4.46507
31A:A:Y290 7.085137
32A:A:Y296 9.54404
33A:A:E298 6.584134
34A:A:Y320 5.73507
35A:A:F323 5.84114
36A:A:T324 5.99254169
37A:A:C325 4.375407
38A:A:Q333 6.74485
39A:A:F336 6.2825488
40A:A:C351 5.515434
41A:A:L353 6.7875437
42B:B:L4 3.395404
43B:B:V40 5.46693
44B:B:H54 9.05333629
45B:B:Y59 7.908568
46B:B:M61 4.2425426
47B:B:W63 6.02286727
48B:B:D76 6.63429
49B:B:K78 5.3525408
50B:B:L79 5.0675407
51B:B:I80 8.9925428
52B:B:W82 8.6075829
53B:B:N88 6.29407
54B:B:K89 8.588529
55B:B:H91 5.6325405
56B:B:I93 4.7175407
57B:B:L95 5.8875408
58B:B:W99 9.4375819
59B:B:Y105 4.788577176
60B:B:N110 6.9254184
61B:B:Y111 7.0485184
62B:B:V112 4.8754178
63B:B:C114 4.3075408
64B:B:L117 5.402519
65B:B:C121 4.135418
66B:B:Y124 5.64167606
67B:B:L126 4.934175
68B:B:L139 7.296509
69B:B:H142 7.582519
70B:B:Y145 6.1475818
71B:B:L146 4.8225417
72B:B:C149 3.84418
73B:B:F151 4.86333609
74B:B:I157 5407
75B:B:T159 6.43519
76B:B:D163 7.975419
77B:B:W169 9.56833618
78B:B:F180 9.6525447
79B:B:H183 9.404549
80B:B:D186 5.716519
81B:B:F199 8.58449
82B:B:V200 6.86456
83B:B:C204 3.72617
84B:B:D205 7.33449
85B:B:K209 12.8825446
86B:B:L210 5.9075405
87B:B:W211 8.85833648
88B:B:Q220 8.55457
89B:B:F222 9.152558
90B:B:H225 9.746559
91B:B:D228 6.97833619
92B:B:I232 5.095458
93B:B:F235 8.55146
94B:B:P236 6.0154147
95B:B:F241 8.8556
96B:B:T243 6.3175458
97B:B:D246 9.125419
98B:B:T249 4.4456
99B:B:R251 12.242558
100B:B:F253 8.488556
101B:B:D254 5.125409
102B:B:D258 10.5457
103B:B:Q259 4.5406
104B:B:E260 7.6375456
105B:B:Y264 6.224505
106B:B:F278 5.843336147
107B:B:R283 9.146599
108B:B:L284 5.0625495
109B:B:L285 5.21406
110B:B:Y289 7.15714767
111B:B:D290 9.7925466
112B:B:C294 5.09475
113B:B:N295 7.265466
114B:B:W297 6.7475468
115B:B:R304 9.9875465
116B:B:H311 8.046579
117B:B:R314 12.995468
118B:B:V315 4.045477
119B:B:T329 5.72408
120B:B:W332 11.9386769
121B:B:D333 6.8325479
122B:B:F335 5.0175404
123B:B:L336 6.0375427
124B:B:K337 7.8675476
125B:B:W339 12.018579
126B:B:N340 5.7525409
127G:G:V16 4.7425407
128G:G:Y40 9.0954146
129G:G:D48 7.455409
130G:G:N59 7.0775409
131G:G:P60 7.52429
132G:G:F61 5.28628
133G:G:R62 3.615407
134R:R:L52 5.695408
135R:R:N59 6.6725438
136R:R:P60 5.19437
137R:R:F61 6.84857738
138R:R:Y64 7.39608
139R:R:L68 5.1525439
140R:R:D72 7.3439
141R:R:F75 5.81754156
142R:R:M79 5.315405
143R:R:E99 6.9854205
144R:R:K102 4.48254203
145R:R:R103 6.00754204
146R:R:Y109 6.896676158
147R:R:Q122 9.245439
148R:R:S126 5.9725438
149R:R:F133 7.51833637
150R:R:R137 6.51833639
151R:R:W150 7.2975409
152R:R:K166 6.4175403
153R:R:R213 10.184235
154R:R:P216 3.84407
155R:R:V222 2.675437
156R:R:L237 6.3954155
157R:R:Y240 8.6175403
158R:R:Y245 4.6154264
159R:R:L256 2.2625402
160R:R:R262 9.065404
161R:R:S268 4.415409
162R:R:N272 6.422539
163R:R:Y276 6.198539
164R:R:F277 4.7075407
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
1B:B:D66 B:B:R68 26.98154.76NoNo085
2B:B:D66 B:B:L69 27.35796.79NoNo085
3B:B:R68 B:B:Y85 20.974426.75NoNo054
4B:B:I93 B:B:P94 20.54193.39YesNo075
5B:B:K78 B:B:P94 20.13283.35YesNo085
6B:B:L69 B:B:Y105 28.03317.03NoYes056
7B:B:V71 B:B:Y105 14.9526.31NoYes1786
8B:B:L79 B:B:V71 15.14554.47YesNo078
9B:B:I93 B:B:L79 11.24995.71YesYes077
10B:B:V112 B:B:Y105 14.99715.05YesYes1786
11B:B:V112 B:B:Y124 15.5993.79YesYes086
12B:B:I93 B:B:Y124 11.26893.63YesYes076
13B:B:C114 B:B:L79 26.81863.17YesYes087
14B:B:C114 B:B:G115 56.18333.92YesNo089
15B:B:G115 B:B:L146 56.36613.42NoYes097
16B:B:H142 B:B:L146 32.27113.86YesYes197
17B:B:H142 B:B:S161 91.264813.95YesNo199
18B:B:G162 B:B:S161 92.2793.71NoNo199
19B:B:G162 B:B:Y145 91.79064.35NoYes198
20A:A:W211 B:B:Y145 86.60515.79YesYes198
21A:A:R208 A:A:W211 98.65457YesYes099
22A:A:L249 A:A:R208 99.17244.86NoYes099
23A:A:F223 A:A:L249 99.1987.31NoNo099
24A:A:F223 A:A:F250 99.272713.93NoYes099
25A:A:C254 A:A:F250 49.98735.59YesYes1059
26A:A:C254 A:A:N255 50.09233.15YesNo1058
27A:A:K312 A:A:N255 50.03499.79NoNo1058
28A:A:K312 A:A:R313 1002.48NoNo054
29A:A:D315 A:A:R313 99.8442.38NoNo034
30A:A:D315 A:A:T316 99.53155.78NoNo033
31A:A:T260 A:A:T316 99.3754.71NoNo033
32A:A:D261 A:A:T260 99.21835.78NoNo043
33A:A:D261 A:A:K349 99.06154.15NoNo045
34A:A:K349 R:R:R282 98.74737.43NoNo055
35A:A:D350 R:R:R282 98.58999.53NoNo045
36B:B:C114 B:B:Y124 28.04526.72YesYes086
37A:A:F250 A:A:L310 50.08693.65YesNo094
38A:A:D251 A:A:L310 50.234510.86YesNo054
39A:A:D251 A:A:K312 50.12095.53YesNo1055
40A:A:D350 R:R:F61 90.24664.78NoYes348
41R:R:F61 R:R:Q122 23.908714.05YesYes389
42A:A:W211 B:B:L117 25.28125.69YesYes199
43A:A:F250 A:A:L266 34.47786.09YesNo099
44A:A:L266 A:A:L268 33.83926.92NoNo098
45A:A:L227 A:A:L268 33.35118.3NoNo1178
46A:A:F274 A:A:L227 33.28357.31YesNo097
47A:A:F274 A:A:Y296 27.85354.13YesYes094
48A:A:K271 A:A:Y296 27.21965.97NoYes054
49A:A:C325 A:A:K271 27.06073.23YesNo075
50A:A:C325 A:A:D328 26.5836.22YesNo079
51A:A:D328 A:A:T324 14.85175.78NoYes1699
52A:A:F267 A:A:T324 11.43726.49YesYes1699
53A:A:F267 A:A:I265 12.46923.77YesYes098
54A:A:D328 A:A:N331 11.57174.04NoNo1698
55A:A:F267 A:A:N331 11.40536.04YesNo1698
56A:A:F267 A:A:H322 10.04259.05YesNo099
57A:A:C214 B:B:L117 26.58893.17NoYes079
58A:A:C214 B:B:Y59 26.36865.38NoYes078
59B:B:W332 B:B:Y59 25.24036.75YesYes698
60B:B:Y85 G:G:P60 15.812412.52NoYes249
61B:B:W297 B:B:Y264 12.17655.79YesYes085
62B:B:W297 B:B:Y289 12.87428.68YesYes687
63B:B:C271 B:B:Y289 15.06434.03NoYes657
64B:B:C271 B:B:D290 22.9336.22NoYes656
65B:B:D290 B:B:R314 23.477823.82YesYes668
66A:A:C351 R:R:F61 59.09498.38YesYes348
67A:A:C351 R:R:R123 54.57496.96YesNo349
68B:B:C121 B:B:L146 12.40133.17YesYes187
69B:B:C121 B:B:C149 12.2573.64YesYes188
70B:B:C149 B:B:T102 79.34415.07YesNo088
71B:B:C148 B:B:T102 79.18263.38NoNo068
72B:B:C148 B:B:S160 78.85923.44NoNo066
73B:B:S160 B:B:V187 78.53514.85NoNo069
74B:B:C166 B:B:V187 50.67713.42NoNo489
75B:B:C166 B:B:F199 50.50424.19NoYes489
76B:B:F199 B:B:V158 25.17295.24YesNo095
77B:B:L192 B:B:V158 24.98554.47NoNo055
78B:B:L152 B:B:L192 24.79816.92NoNo035
79B:B:L152 B:B:Q156 24.42359.32NoNo035
80B:B:Q156 B:B:R214 24.04883.5NoNo059
81B:B:R197 B:B:R214 71.611211.73NoNo059
82B:B:D195 B:B:R197 71.02963.57NoNo055
83B:B:D195 B:B:P194 69.86593.22NoNo054
84B:B:F234 B:B:P194 68.70154.33NoNo054
85B:B:F234 B:B:V200 67.53647.87NoYes056
86B:B:L210 B:B:V200 29.04524.47YesYes056
87B:B:L210 B:B:Q220 24.91355.32YesYes057
88B:B:D258 B:B:Q220 23.727616.97YesYes577
89B:B:D258 B:B:R22 43.962510.72YesNo076
90B:B:I18 B:B:R22 26.1686.26NoNo076
91B:B:I18 G:G:A23 24.98033.25NoNo078
92B:B:L14 G:G:A23 22.60451.58NoNo088
93B:B:L14 G:G:K20 19.03947.05NoNo086
94G:G:K20 G:G:V16 17.85071.52NoYes067
95B:B:L7 G:G:V16 14.28361.49NoYes087
96B:B:L146 B:B:T159 12.14698.84YesYes179
97B:B:C149 B:B:T159 66.83043.38YesYes189
98B:B:F180 B:B:F199 25.165712.86YesYes479
99B:B:F180 B:B:T178 49.68245.19YesNo474
100B:B:L168 B:B:T178 48.90424.42NoNo464
101B:B:L168 B:B:V213 48.53144.47NoNo064
102B:B:R214 B:B:V213 48.14776.54NoNo094
103B:B:S201 B:B:V187 27.69563.23NoNo499
104B:B:S201 B:B:W211 27.51277.41NoYes498
105B:B:F180 B:B:W211 25.28416.04YesYes478
106B:B:F241 B:B:V200 32.002210.49YesYes566
107B:B:F222 B:B:F241 24.307912.86YesYes586
108B:B:D258 B:B:F222 23.7894.78YesYes578
109B:B:Q259 B:B:R22 16.66194.67YesNo066
110B:B:C25 B:B:Q259 13.09433.05NoYes036
111B:B:C25 G:G:K29 11.90474.85NoNo034
112B:B:D27 G:G:K29 10.71513.83NoNo084
113B:B:H54 B:B:W82 10.32543.17YesYes299
114B:B:D76 B:B:H54 16.18546.3YesYes299
115R:R:R123 R:R:Y276 54.94177.2NoYes399
116R:R:N272 R:R:Y276 54.56195.81YesYes399
117R:R:D72 R:R:N272 36.99676.73YesYes399
118R:R:D72 R:R:S269 36.558710.31YesNo099
119R:R:F75 R:R:S269 28.00667.93YesNo069
120R:R:M79 R:R:R262 11.15796.2YesYes054
121R:R:Q122 R:R:Y64 20.963812.4YesYes098
122R:R:C146 R:R:Y64 19.44714.03NoYes078
123R:R:C146 R:R:N67 19.071812.6NoNo079
124R:R:N67 R:R:W150 18.75995.65NoYes099
125R:R:F75 R:R:Y109 16.37615.16YesYes1568
126R:R:N272 R:R:S268 17.23424.47YesYes099
127R:R:S234 R:R:S268 16.41246.52NoYes079
128R:R:L113 R:R:S234 16.21434.5NoNo087
129R:R:L113 R:R:Y109 16.017414.07NoYes088
130R:R:S238 R:R:Y109 17.41943.82NoYes078
131R:R:Q182 R:R:T110 16.25817.09NoNo066
132R:R:I186 R:R:S238 12.79984.64NoNo077
133R:R:I186 R:R:L190 24.19242.85NoNo078
134R:R:I186 R:R:Q182 12.67185.49NoNo076
135R:R:L190 R:R:T117 21.69648.84NoNo088
136R:R:M194 R:R:T117 20.03153.01NoNo088
137R:R:M194 R:R:S120 11.69697.67NoNo089
138B:B:D76 B:B:K78 17.72928.3YesYes098
139B:B:R314 B:B:W332 23.801618.99YesYes689
140B:B:H142 B:B:T159 55.22436.85YesYes199
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


PDB Summary
PDB 7Y15
Class A
SubFamily Orphan
Type A orphans
SubType MRGPRD
Species Homo sapiens
Ligand -
Other Ligand(s) -
Protein Partners Gi1/Beta1/Gamma2
PDB Resolution 2.9
Date 2022-07-20
D.O.I. 10.1038/s42003-022-03668-3
Net Summary
Imin 3.09
Number of Linked Nodes 831
Number of Links 1011
Number of Hubs 164
Number of Links mediated by Hubs 581
Number of Communities 26
Number of Nodes involved in Communities 220
Number of Links involved in Communities 322
Path Summary
Number Of Nodes in MetaPath 141
Number Of Links MetaPath 140
Number of Shortest Paths 2045289
Length Of Smallest Path 3
Average Path Length 38.4084
Length of Longest Path 72
Minimum Path Strength 1.13
Average Path Strength 6.35477
Maximum Path Strength 23.5533
Minimum Path Correlation 0.7
Average Path Correlation 0.986586
Maximum Path Correlation 1
Minimum % Of Corr. Nodes 2.63158
Average % Of Corr. Nodes 36.4717
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 40.097
Maximum Path Hubs % 100
AnnotationTypeLinks
Gene OntologyMolecular Function
Gene OntologyBiological Process
Gene OntologyCellular Component
SCOP2Domain Identifier
SCOP2Family Identifier
Membrane Protein Annotations-• Orientations of Proteins in Membranes database (OPM)   • Protein Data Bank of Transmembrane Proteins (PDBTM)   • MemProtMD


Details about the values in these tables can be found in the corresponding documentation page .
PDBsumOpen PDBsum Page
ChainA
ProteinG Protein α Sub unit
UniProtP63096
Sequence
>7Y15_Chain_A
CTLSAEDKA AVERSKMID RNLREDGEK AAREVKLLL LGAGESGKS 
TIVKQMKTG IVETHFTFK DLHFKMFDV GAQRSERKK WIHCFEGVA 
AIIFCVALS DYDLMNRMH ESMKLFDSI CNNKWFTDT SIILFLNKK 
DLFEEKIKK SPLTICYQE YAGSNTYEE AAAYIQCQF EDLNKRKDT 
KEIYTHFTC STDTKNVQF VFDAVTDVI IKNNLKDCG LF


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainB
ProteinG Protein β Sub unit
UniProtP62874
Sequence
>7Y15_Chain_B
ELDQLRQEA EQLKNQIRD ARKACADAT LSQITNNID PVGRIQMRT 
RRTLRGHLA KIYAMHWGT DSRLLVSAS QDGKLIIWD SYTTNKVHA 
IPLRSSWVM TCAYAPSGN YVACGGLDN ICSIYNLKT REGNVRVSR 
ELAGHTGYL SCCRFLDDN QIVTSSGDT TCALWDIET GQQTTTFTG 
HTGDVMSLS LAPDTRLFV SGACDASAK LWDVREGMC RQTFTGHES 
DINAICFFP NGNAFATGS DDATCRLFD LRADQELMT YSHDNIICG 
ITSVSFSKS GRLLLAGYD DFNCNVWDA LKADRAGVL AGHDNRVSC 
LGVTDDGMA VATGSWDSF LKIWN


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainG
ProteinG Protein γ Sub unit
UniProtP63213
Sequence
>7Y15_Chain_G
ASIAQARKL VEQLKMEAN IDRIKVSKA AADLMAYCE AHAKEDPLL 
TPVPASENP FRE


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainR
ProteinReceptor
UniProtQ8TDS7
Sequence
>7Y15_Chain_R
TVHTAYLVL SSLAMFTCL CGMAGNSMV IWLLGFRMH RNPFCIYIL 
NLAAADLLF LFSMASTLS LETQPLVNT TDKVHELMK RLMYFAYTV 
GLSLLTAIS TQRCLSVLF PIWFKCHRP RHLSAWVCG LLWTLCLLM 
NGLTSSFCS KFLKFNEDR CFRVDMVQA ALIMGVLTP VMTLSSLTL 
FVWVRRSSQ QWRRQPTRL FVVVLASVL VFLICSLPL SIYWFVLYW 
LSLPPEMQV LCFSLSRLS SSVSSSANP VIYFLVGSR RSH


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  




This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
7Y12AOrphanA orphansMRGPRDHomo sapiensBeta-alanine-Gi1/&β;1/&γ;23.12022-07-2010.1038/s42003-022-03668-3
7Y13AOrphanA orphansMRGPRDHomo sapiens---3.12022-07-2010.1038/s42003-022-03668-3
7Y14AOrphanA orphansMRGPRDHomo sapiensBeta-alanine--3.22022-07-2010.1038/s42003-022-03668-3
7Y15AOrphanA orphansMRGPRDHomo sapiens--Gi1/&β;1/&γ;22.92022-07-2010.1038/s42003-022-03668-3




You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download 7Y15.zip



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