psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:R103	5.82	Yes	Yes	1	0	4
2	L:L:?1	R:R:Y106	18.71	Yes	No	1	0	3
3	L:L:?1	R:R:C164	5.06	Yes	Yes	1	0	6
4	L:L:?1	R:R:C175	6.33	Yes	No	1	0	8
5	L:L:?1	R:R:D179	27.07	Yes	Yes	1	0	3
6	L:L:?1	R:R:Q182	4.25	Yes	No	0	0	6
7	L:L:?1	R:R:A183	6.29	Yes	No	0	0	5
8	L:L:?1	R:R:S238	4.79	Yes	No	0	0	7
9	L:L:?1	R:R:W241	22.72	Yes	No	1	0	4
10	L:L:?1	R:R:F242	4.86	Yes	No	0	0	5
11	L:L:?1	R:R:Y245	5.61	Yes	Yes	1	0	4
12	R:R:E252	R:R:V23	9.98	No	Yes	0	2	1
13	R:R:E86	R:R:Y27	4.49	No	No	0	3	3
14	R:R:L30	R:R:S259	7.51	No	No	0	5	3
15	R:R:L263	R:R:L33	9.69	No	No	0	5	5
16	R:R:A34	R:R:L263	4.73	No	No	0	6	5
17	R:R:L83	R:R:M35	4.24	No	No	0	6	4
18	R:R:S266	R:R:T37	6.4	No	No	0	6	7
19	R:R:C38	R:R:M79	4.86	No	Yes	0	6	5
20	R:R:L73	R:R:M42	9.9	No	No	0	7	7
21	R:R:F77	R:R:M42	3.73	No	No	0	4	7
22	R:R:G44	R:R:M47	3.49	No	No	0	9	6
23	R:R:A69	R:R:N45	4.69	No	No	0	9	9
24	R:R:D72	R:R:N45	12.12	No	No	0	9	9
25	R:R:L73	R:R:N45	6.87	No	No	0	7	9
26	R:R:L73	R:R:S46	7.51	No	No	0	7	6
27	R:R:A69	R:R:V48	3.39	No	No	0	9	9
28	R:R:F277	R:R:V48	3.93	No	No	0	7	9
29	R:R:I49	R:R:L66	4.28	No	No	0	7	8
30	R:R:L51	R:R:L52	4.15	No	Yes	5	7	8
31	R:R:F277	R:R:L51	13.4	No	No	5	7	7
32	R:R:F277	R:R:L52	8.53	No	Yes	5	7	8
33	R:R:F61	R:R:I65	15.07	No	No	0	8	8
34	R:R:F61	R:R:I119	5.02	No	No	2	8	9
35	R:R:F61	R:R:R123	8.55	No	No	2	8	9
36	R:R:I63	R:R:S142	9.29	No	No	0	7	9
37	R:R:A118	R:R:Y64	5.34	No	Yes	0	8	8
38	R:R:I119	R:R:Y64	4.84	No	Yes	0	9	8
39	R:R:Q122	R:R:Y64	10.15	No	Yes	0	9	8
40	R:R:S142	R:R:Y64	13.99	No	Yes	0	9	8
41	R:R:V145	R:R:Y64	8.83	No	Yes	0	6	8
42	R:R:I65	R:R:Y276	6.04	No	Yes	0	8	9
43	R:R:C146	R:R:N67	11.02	No	No	0	7	9
44	R:R:N67	R:R:W150	5.65	No	Yes	0	9	9
45	R:R:L115	R:R:L68	5.54	No	Yes	0	7	9
46	R:R:L116	R:R:L68	4.15	Yes	Yes	2	9	9
47	R:R:L68	R:R:N272	5.49	Yes	No	2	9	9
48	R:R:L68	R:R:Y276	4.69	Yes	Yes	2	9	9
49	R:R:D72	R:R:L76	8.14	No	No	3	9	7
50	R:R:D72	R:R:S269	8.83	No	No	3	9	9
51	R:R:A108	R:R:L74	4.73	No	No	0	7	6
52	R:R:F75	R:R:M79	3.73	Yes	Yes	3	6	5
53	R:R:F75	R:R:M105	4.98	Yes	No	3	6	4
54	R:R:A108	R:R:F75	4.16	No	Yes	0	7	6
55	R:R:F75	R:R:Y109	6.19	Yes	Yes	0	6	8
56	R:R:F75	R:R:S269	5.28	Yes	No	3	6	9
57	R:R:L76	R:R:S269	4.5	No	No	3	7	9
58	R:R:F77	R:R:S81	7.93	No	No	0	4	5
59	R:R:M105	R:R:S78	6.13	No	No	0	4	5
60	R:R:M105	R:R:M79	5.78	No	Yes	3	4	5
61	R:R:M79	R:R:R262	11.17	Yes	Yes	0	5	4
62	R:R:M79	R:R:S266	4.6	Yes	No	0	5	6
63	R:R:M101	R:R:S81	4.6	No	No	0	4	5
64	R:R:H98	R:R:T82	4.11	No	No	0	5	3
65	R:R:R262	R:R:T82	5.17	Yes	No	0	4	3
66	R:R:L83	R:R:R262	6.07	No	Yes	0	6	4
67	R:R:E86	R:R:H98	6.15	No	No	0	3	5
68	R:R:D95	R:R:L90	8.14	No	No	0	1	1
69	R:R:T94	R:R:V91	11.11	No	No	0	1	4
70	R:R:D95	R:R:F167	3.58	No	No	0	1	1
71	R:R:F167	R:R:K96	3.72	No	No	0	1	1
72	R:R:E99	R:R:R103	9.3	No	Yes	1	5	4
73	R:R:E99	R:R:S165	8.62	No	No	1	5	3
74	R:R:E99	R:R:K166	4.05	No	No	0	5	3
75	R:R:L100	R:R:M101	4.24	No	No	0	4	4
76	R:R:K102	R:R:R103	7.43	No	Yes	0	3	4
77	R:R:K102	R:R:Y106	9.55	No	No	0	3	3
78	R:R:R103	R:R:S161	5.27	Yes	No	0	4	3
79	R:R:R103	R:R:S165	5.27	Yes	No	1	4	3
80	R:R:W241	R:R:Y106	7.72	No	No	1	4	3
81	R:R:F107	R:R:V111	3.93	Yes	No	4	5	7
82	R:R:F107	R:R:W150	6.01	Yes	Yes	4	5	9
83	R:R:C153	R:R:F107	4.19	Yes	Yes	4	8	5
84	R:R:F107	R:R:L154	6.09	Yes	No	0	5	4
85	R:R:F107	R:R:N157	6.04	Yes	Yes	4	5	7
86	R:R:L113	R:R:Y109	9.38	No	Yes	0	8	8
87	R:R:L237	R:R:Y109	7.03	No	Yes	0	5	8
88	R:R:S238	R:R:Y109	7.63	No	Yes	0	7	8
89	R:R:C153	R:R:T110	6.76	Yes	No	4	8	6
90	R:R:N157	R:R:T110	8.77	Yes	No	4	7	6
91	R:R:V111	R:R:W150	12.26	No	Yes	4	7	9
92	R:R:C153	R:R:V111	5.12	Yes	No	4	8	7
93	R:R:F230	R:R:L113	8.53	Yes	No	0	9	8
94	R:R:L149	R:R:S114	6.01	No	No	0	7	7
95	R:R:F230	R:R:L116	7.31	Yes	Yes	2	9	9
96	R:R:L116	R:R:N272	6.87	Yes	No	2	9	9
97	R:R:L116	R:R:Y276	4.69	Yes	Yes	2	9	9
98	R:R:L190	R:R:T117	7.37	No	No	0	8	8
99	R:R:T117	R:R:V193	4.76	No	No	0	8	6
100	R:R:I119	R:R:R123	6.26	No	No	2	9	9
101	R:R:M194	R:R:S120	9.2	No	No	0	8	9
102	R:R:S120	R:R:S197	4.89	No	No	0	9	8
103	R:R:F133	R:R:Q122	3.51	No	No	6	7	9
104	R:R:Q122	R:R:R137	5.84	No	Yes	6	9	9
105	R:R:R123	R:R:Y276	4.12	No	Yes	2	9	9
106	R:R:C124	R:R:L128	4.76	No	Yes	0	8	6
107	R:R:C124	R:R:S197	3.44	No	No	0	8	8
108	R:R:F133	R:R:S126	7.93	No	No	0	7	8
109	R:R:L201	R:R:V127	4.47	No	No	0	8	8
110	R:R:F129	R:R:L128	9.74	No	Yes	0	5	6
111	R:R:L128	R:R:T200	4.42	Yes	No	7	6	5
112	R:R:L128	R:R:W204	4.56	Yes	Yes	7	6	6
113	R:R:R137	R:R:W132	9	Yes	No	0	9	6
114	R:R:F133	R:R:R137	9.62	No	Yes	6	7	9
115	R:R:C135	R:R:H136	5.9	No	No	0	7	6
116	R:R:L141	R:R:R137	4.86	No	Yes	0	5	9
117	R:R:L141	R:R:P138	8.21	No	No	0	5	8
118	R:R:H140	R:R:R139	19.18	No	No	0	5	5
119	R:R:C153	R:R:N157	4.72	Yes	Yes	4	8	7
120	R:R:M156	R:R:Q182	12.23	No	No	0	4	6
121	R:R:N157	R:R:Q182	10.56	Yes	No	0	7	6
122	R:R:G158	R:R:S161	3.71	No	No	0	4	3
123	R:R:F163	R:R:L159	6.09	Yes	No	0	4	6
124	R:R:L159	R:R:V178	4.47	No	No	0	6	4
125	R:R:T160	R:R:V178	11.11	No	No	0	4	4
126	R:R:F163	R:R:K169	4.96	Yes	No	0	4	1
127	R:R:F163	R:R:R174	14.97	Yes	No	0	4	1
128	R:R:C164	R:R:C175	7.28	Yes	No	1	6	8
129	R:R:C164	R:R:D179	4.67	Yes	Yes	1	6	3
130	R:R:L168	R:R:S165	10.51	No	No	0	1	3
131	R:R:D173	R:R:N171	10.77	No	No	8	3	5
132	R:R:N171	R:R:R174	7.23	No	No	8	5	1
133	R:R:D173	R:R:R174	9.53	No	No	8	3	1
134	R:R:C175	R:R:D179	4.67	No	Yes	1	8	3
135	R:R:F176	R:R:M180	13.68	No	No	1	2	3
136	R:R:F176	R:R:Y245	10.32	No	Yes	1	2	4
137	R:R:F176	R:R:W246	5.01	No	No	1	2	4
138	R:R:D179	R:R:Y245	6.9	Yes	Yes	1	3	4
139	R:R:M180	R:R:Y245	3.59	No	Yes	1	3	4
140	R:R:M180	R:R:W246	4.65	No	No	1	3	4
141	R:R:L185	R:R:V189	4.47	No	No	0	5	5
142	R:R:F242	R:R:M187	4.98	No	No	0	5	7
143	R:R:G188	R:R:P192	4.06	No	No	0	5	5
144	R:R:P192	R:R:T191	6.99	No	No	0	5	5
145	R:R:F230	R:R:T191	6.49	Yes	No	2	9	5
146	R:R:L231	R:R:T191	4.42	No	No	2	8	5
147	R:R:F230	R:R:M194	4.98	Yes	No	0	9	8
148	R:R:T200	R:R:W204	4.85	No	Yes	7	5	6
149	R:R:L201	R:R:L219	4.15	No	No	0	8	7
150	R:R:L201	R:R:V223	4.47	No	No	0	8	8
151	R:R:F202	R:R:F220	12.86	No	No	0	5	5
152	R:R:V203	R:R:W204	6.13	No	Yes	0	5	6
153	R:R:L219	R:R:V205	5.96	No	No	0	7	6
154	R:R:F220	R:R:R206	8.55	No	No	0	5	5
155	R:R:S208	R:R:W212	4.94	No	No	0	5	3
156	R:R:S209	R:R:W212	19.77	No	No	9	7	3
157	R:R:P216	R:R:S209	7.13	Yes	No	9	7	7
158	R:R:P216	R:R:W212	5.4	Yes	No	9	7	3
159	R:R:V222	R:R:V279	4.81	No	No	0	7	7
160	R:R:S226	R:R:Y276	6.36	No	Yes	0	7	9
161	R:R:I232	R:R:L228	5.71	No	No	0	5	6
162	R:R:F230	R:R:L231	3.65	Yes	No	2	9	8
163	R:R:C233	R:R:S264	3.44	No	No	0	7	7
164	R:R:S234	R:R:S268	6.52	No	Yes	0	7	9
165	R:R:I239	R:R:L235	5.71	No	No	0	6	6
166	R:R:L237	R:R:S265	6.01	No	No	0	5	8
167	R:R:L244	R:R:Y240	10.55	No	Yes	0	3	3
168	R:R:C257	R:R:Y240	8.06	No	Yes	0	4	3
169	R:R:F258	R:R:Y240	10.32	No	Yes	0	3	3
170	R:R:L244	R:R:Q254	7.99	No	No	0	3	2
171	R:R:W246	R:R:Y245	5.79	No	Yes	1	4	4
172	R:R:L249	R:R:P250	4.93	No	No	0	3	1
173	R:R:L249	R:R:M253	8.48	No	No	0	3	1
174	R:R:E252	R:R:L256	5.3	No	No	0	2	2
175	R:R:F258	R:R:R262	8.55	No	Yes	0	3	4
176	R:R:N272	R:R:S268	4.47	No	Yes	0	9	9
177	R:R:I275	R:R:Y276	4.84	No	Yes	0	8	9
178	R:R:C164	R:R:T160	3.38	Yes	No	0	6	4
179	R:R:C233	R:R:I232	3.27	No	No	0	7	5
180	R:R:S120	R:R:S198	3.26	No	No	0	9	8
181	R:R:S198	R:R:V223	3.23	No	No	0	8	8
182	R:R:S198	R:R:V227	3.23	No	No	0	8	8
183	R:R:S268	R:R:V229	3.23	Yes	No	0	9	7
184	R:R:S270	R:R:V267	3.23	No	No	0	8	5
185	R:R:A80	R:R:M35	3.22	No	No	0	6	4
186	R:R:V23	R:R:V255	3.21	Yes	No	0	1	1
187	R:R:S270	R:R:T37	3.2	No	No	0	8	7
188	R:R:H136	R:R:W132	3.17	No	No	0	6	6
189	R:R:H140	R:R:W144	3.17	No	No	0	5	5
190	R:R:T195	R:R:V227	3.17	No	No	0	4	8
191	R:R:T22	R:R:T25	3.14	No	No	0	1	2
192	R:R:I186	R:R:S238	3.1	No	No	0	7	7
193	R:R:M156	R:R:V181	3.04	No	No	0	4	3
194	R:R:L28	R:R:S32	3	No	No	0	4	5
195	R:R:R207	R:R:W204	3	No	Yes	0	5	6
196	R:R:L85	R:R:V97	2.98	No	No	0	3	5
197	R:R:L149	R:R:V145	2.98	No	No	0	7	6
198	R:R:L190	R:R:V189	2.98	No	No	0	8	5
199	R:R:L125	R:R:T121	2.95	No	No	0	6	6
200	L:L:?1	R:R:F170	2.92	Yes	No	0	0	1
201	R:R:D95	R:R:T94	2.89	No	No	0	1	1
202	R:R:C40	R:R:F36	2.79	No	No	0	6	5
203	R:R:H24	R:R:V23	2.77	No	Yes	0	1	1
204	R:R:L263	R:R:L30	2.77	No	No	0	5	5
205	R:R:L52	R:R:L66	2.77	Yes	No	0	8	8
206	R:R:L104	R:R:L74	2.77	No	No	0	5	6
207	R:R:L100	R:R:L104	2.77	No	No	0	4	5
208	R:R:P138	R:R:W144	2.7	No	No	0	8	5
209	R:R:F163	R:R:S162	2.64	Yes	No	0	4	3
210	R:R:F220	R:R:V205	2.62	No	No	0	5	6
211	R:R:R218	R:R:V279	2.62	No	No	0	7	7
212	R:R:A71	R:R:W150	2.59	No	Yes	0	9	9
213	R:R:S31	R:R:Y27	2.54	No	No	0	3	3
214	R:R:F167	R:R:K166	2.48	No	No	0	1	3
215	R:R:F129	R:R:L125	2.44	No	No	0	5	6
216	R:R:C40	R:R:G41	1.96	No	No	0	6	9
217	R:R:A43	R:R:G44	1.95	No	No	0	5	9
218	R:R:A71	R:R:G112	1.95	No	No	0	9	9
219	R:R:P250	R:R:P251	1.95	No	No	0	1	2
220	R:R:C62	R:R:P60	1.88	No	No	0	8	7
221	R:R:G41	R:R:S270	1.86	No	No	0	9	8
222	R:R:P236	R:R:S261	1.78	No	No	0	9	5
223	R:R:P236	R:R:S264	1.78	No	No	0	9	7
224	R:R:P273	R:R:V48	1.77	No	No	0	9	9
225	R:R:P216	R:R:V205	1.77	Yes	No	0	7	6
226	R:R:C233	R:R:S268	1.72	No	Yes	0	7	9
227	R:R:A34	R:R:S266	1.71	No	No	0	6	6
228	R:R:A271	R:R:V229	1.7	No	No	0	7	7
229	R:R:C135	R:R:I131	1.64	No	No	0	7	7
230	R:R:L235	R:R:P236	1.64	No	No	0	6	9
231	R:R:C135	R:R:K134	1.62	No	No	0	7	7
232	R:R:S226	R:R:V222	1.62	No	No	0	7	7
233	R:R:A225	R:R:I275	1.62	No	No	0	6	8
234	R:R:V221	R:R:V222	1.6	No	No	0	6	7
235	R:R:T22	R:R:V23	1.59	No	Yes	0	1	1
236	R:R:C62	R:R:L52	1.59	No	Yes	0	8	8
237	R:R:T93	R:R:V91	1.59	No	No	0	2	4
238	R:R:A26	R:R:L30	1.58	No	No	0	3	5
239	R:R:P89	R:R:Q88	1.58	No	No	0	3	4
240	R:R:P216	R:R:Q215	1.58	Yes	No	0	7	5
241	R:R:T117	R:R:T121	1.57	No	No	0	8	6
242	R:R:M101	R:R:V97	1.52	No	No	0	4	5
243	R:R:L85	R:R:S84	1.5	No	No	0	3	5
244	R:R:L256	R:R:S259	1.5	No	No	0	2	3
245	R:R:L199	R:R:V203	1.49	No	No	0	5	5
246	R:R:L278	R:R:V274	1.49	No	No	0	7	6
247	R:R:L278	R:R:V279	1.49	No	No	0	7	7
248	R:R:L196	R:R:T195	1.47	No	No	0	4	4
249	R:R:N92	R:R:T93	1.46	No	No	0	5	2
250	R:R:F129	R:R:P130	1.44	No	No	0	5	9
251	R:R:Q88	R:R:T87	1.42	No	No	0	4	4
252	R:R:L152	R:R:L155	1.38	No	No	0	6	4
253	R:R:L249	R:R:Q254	1.33	No	No	0	3	2
254	R:R:E172	R:R:N171	1.31	No	No	0	3	5
255	R:R:Q210	R:R:Q211	1.28	No	No	0	5	5
256	R:R:V243	R:R:Y240	1.26	No	Yes	0	5	3
257	R:R:Q211	R:R:R213	1.17	No	No	0	5	5

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	L:L:?1	9.53583	12	1	0
2	R:R:V23	4.3875	4	0	1
3	R:R:L52	4.26	4	5	8
4	R:R:Y64	8.63	5	0	8
5	R:R:L68	4.9675	4	2	9
6	R:R:F75	4.868	5	3	6
7	R:R:M79	6.028	5	3	5
8	R:R:R103	6.618	5	1	4
9	R:R:F107	5.252	5	4	5
10	R:R:Y109	7.5575	4	0	8
11	R:R:L116	5.755	4	2	9
12	R:R:L128	5.87	4	7	6
13	R:R:R137	7.33	4	6	9
14	R:R:W150	6.6275	4	4	9
15	R:R:C153	5.1975	4	4	8
16	R:R:N157	7.5225	4	4	7
17	R:R:F163	7.165	4	0	4
18	R:R:C164	5.0975	4	1	6
19	R:R:D179	10.8275	4	1	3
20	R:R:W204	4.635	4	7	6
21	R:R:P216	3.97	4	9	7
22	R:R:F230	6.192	5	2	9
23	R:R:Y240	7.5475	4	0	3
24	R:R:Y245	6.442	5	1	4
25	R:R:R262	7.74	4	0	4
26	R:R:S268	3.985	4	0	9
27	R:R:Y276	5.12333	6	2	9

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:S238	76.7914	4.79	Yes	No	0	0	7
2	R:R:S238	R:R:Y109	78.6011	7.63	No	Yes	0	7	8
3	R:R:F75	R:R:Y109	88.5873	6.19	Yes	Yes	0	6	8
4	R:R:F75	R:R:M79	60.2429	3.73	Yes	Yes	3	6	5
5	R:R:M79	R:R:S266	33.2518	4.6	Yes	No	0	5	6
6	R:R:A34	R:R:S266	22.2385	1.71	No	No	0	6	6
7	R:R:A34	R:R:L263	20.6	4.73	No	No	0	6	5
8	R:R:L263	R:R:L30	17.2577	2.77	No	No	0	5	5
9	R:R:L30	R:R:S259	13.8583	7.51	No	No	0	5	3
10	R:R:L256	R:R:S259	12.3094	1.5	No	No	0	2	3
11	R:R:E252	R:R:L256	10.5731	5.3	No	No	0	2	2
12	R:R:M79	R:R:R262	31.3361	11.17	Yes	Yes	0	5	4
13	R:R:S266	R:R:T37	10.7524	6.4	No	No	0	6	7
14	R:R:F75	R:R:S269	29.665	5.28	Yes	No	3	6	9
15	R:R:D72	R:R:S269	26.4286	8.83	No	No	3	9	9
16	R:R:D72	R:R:N45	25.0917	12.12	No	No	0	9	9
17	R:R:A69	R:R:N45	17.6001	4.69	No	No	0	9	9
18	R:R:A69	R:R:V48	15.9126	3.39	No	No	0	9	9
19	R:R:F277	R:R:V48	12.4888	3.93	No	No	0	7	9
20	R:R:L113	R:R:Y109	100	9.38	No	Yes	0	8	8
21	R:R:F230	R:R:L113	99.6821	8.53	Yes	No	0	9	8
22	R:R:F230	R:R:L116	73.0578	7.31	Yes	Yes	2	9	9
23	R:R:L116	R:R:Y276	54.4713	4.69	Yes	Yes	2	9	9
24	R:R:R123	R:R:Y276	40.9636	4.12	No	Yes	2	9	9
25	R:R:I119	R:R:R123	37.8006	6.26	No	No	2	9	9
26	R:R:I119	R:R:Y64	36.5778	4.84	No	Yes	0	9	8
27	R:R:Q122	R:R:Y64	25.0836	10.15	No	Yes	0	9	8
28	L:L:?1	R:R:Q182	25.4259	4.25	Yes	No	0	0	6
29	R:R:N157	R:R:Q182	20.6163	10.56	Yes	No	0	7	6
30	R:R:F107	R:R:N157	14.0214	6.04	Yes	Yes	4	5	7
31	R:R:L116	R:R:N272	22.3527	6.87	Yes	No	2	9	9
32	R:R:A108	R:R:F75	14.7795	4.16	No	Yes	0	7	6
33	R:R:A108	R:R:L74	13.092	4.73	No	No	0	7	6
34	R:R:L104	R:R:L74	11.3883	2.77	No	No	0	5	6
35	L:L:?1	R:R:R103	27.0156	5.82	Yes	Yes	1	0	4
36	R:R:E99	R:R:R103	17.437	9.3	No	Yes	1	5	4
37	R:R:E99	R:R:K166	15.9126	4.05	No	No	0	5	3
38	R:R:F167	R:R:K166	14.2089	2.48	No	No	0	1	3
39	R:R:D95	R:R:F167	10.7443	3.58	No	No	0	1	1
40	R:R:F230	R:R:M194	55.0583	4.98	Yes	No	0	9	8
41	R:R:M194	R:R:S120	53.7947	9.2	No	No	0	8	9
42	R:R:S120	R:R:S197	28.809	4.89	No	No	0	9	8
43	R:R:C124	R:R:S197	27.2357	3.44	No	No	0	8	8
44	R:R:C124	R:R:L128	25.646	4.76	No	Yes	0	8	6
45	R:R:F129	R:R:L128	15.8963	9.74	No	Yes	0	5	6
46	R:R:F129	R:R:L125	12.4725	2.44	No	No	0	5	6
47	R:R:L125	R:R:T121	10.7361	2.95	No	No	0	6	6
48	R:R:S120	R:R:S198	28.3933	3.26	No	No	0	9	8
49	R:R:S198	R:R:V223	21.994	3.23	No	No	0	8	8
50	R:R:L201	R:R:V223	20.494	4.47	No	No	0	8	8
51	R:R:Q122	R:R:R137	19.85	5.84	No	Yes	6	9	9
52	L:L:?1	R:R:C164	19.0919	5.06	Yes	Yes	1	0	6
53	R:R:C164	R:R:T160	17.9261	3.38	Yes	No	0	6	4
54	R:R:T160	R:R:V178	16.2061	11.11	No	No	0	4	4
55	R:R:L159	R:R:V178	14.4697	4.47	No	No	0	6	4
56	R:R:F163	R:R:L159	12.717	6.09	Yes	No	0	4	6
57	R:R:L201	R:R:L219	17.2821	4.15	No	No	0	8	7
58	R:R:L219	R:R:V205	15.7496	5.96	No	No	0	7	6
59	R:R:S226	R:R:Y276	13.2306	6.36	No	Yes	0	7	9
60	R:R:S226	R:R:V222	11.3883	1.62	No	No	0	7	7
61	R:R:N272	R:R:S268	24.4477	4.47	No	Yes	0	9	9
62	R:R:C233	R:R:S268	16.5566	1.72	No	Yes	0	7	9
63	R:R:C233	R:R:S264	10.4671	3.44	No	No	0	7	7
64	R:R:F258	R:R:R262	17.2414	8.55	No	Yes	0	3	4
65	R:R:F258	R:R:Y240	15.7333	10.32	No	Yes	0	3	3
66	R:R:L244	R:R:Y240	10.7361	10.55	No	Yes	0	3	3

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:?1	R:R:R103	5.82	1	Yes	Yes	0	4	0	1
L:L:?1	R:R:Y106	18.71	1	Yes	No	0	3	0	1
L:L:?1	R:R:C164	5.06	1	Yes	Yes	0	6	0	1
L:L:?1	R:R:C175	6.33	1	Yes	No	0	8	0	1
L:L:?1	R:R:D179	27.07	1	Yes	Yes	0	3	0	1
L:L:?1	R:R:Q182	4.25	1	Yes	No	0	6	0	1
L:L:?1	R:R:A183	6.29	1	Yes	No	0	5	0	1
L:L:?1	R:R:S238	4.79	1	Yes	No	0	7	0	1
L:L:?1	R:R:W241	22.72	1	Yes	No	0	4	0	1
L:L:?1	R:R:F242	4.86	1	Yes	No	0	5	0	1
L:L:?1	R:R:Y245	5.61	1	Yes	Yes	0	4	0	1
R:R:E99	R:R:R103	9.3	1	No	Yes	5	4	2	1
R:R:E99	R:R:S165	8.62	1	No	No	5	3	2	2
R:R:K102	R:R:R103	7.43	0	No	Yes	3	4	2	1
R:R:K102	R:R:Y106	9.55	0	No	No	3	3	2	1
R:R:R103	R:R:S161	5.27	1	Yes	No	4	3	1	2
R:R:R103	R:R:S165	5.27	1	Yes	No	4	3	1	2
R:R:W241	R:R:Y106	7.72	1	No	No	4	3	1	1
R:R:S238	R:R:Y109	7.63	0	No	Yes	7	8	1	2
R:R:M156	R:R:Q182	12.23	0	No	No	4	6	2	1
R:R:N157	R:R:Q182	10.56	4	Yes	No	7	6	2	1
R:R:C164	R:R:C175	7.28	1	Yes	No	6	8	1	1
R:R:C164	R:R:D179	4.67	1	Yes	Yes	6	3	1	1
R:R:C175	R:R:D179	4.67	1	No	Yes	8	3	1	1
R:R:F176	R:R:M180	13.68	1	No	No	2	3	2	2
R:R:F176	R:R:Y245	10.32	1	No	Yes	2	4	2	1
R:R:F176	R:R:W246	5.01	1	No	No	2	4	2	2
R:R:D179	R:R:Y245	6.9	1	Yes	Yes	3	4	1	1
R:R:M180	R:R:Y245	3.59	1	No	Yes	3	4	2	1
R:R:M180	R:R:W246	4.65	1	No	No	3	4	2	2
R:R:F242	R:R:M187	4.98	0	No	No	5	7	1	2
R:R:W246	R:R:Y245	5.79	1	No	Yes	4	4	2	1
R:R:C164	R:R:T160	3.38	1	Yes	No	6	4	1	2
R:R:I186	R:R:S238	3.1	0	No	No	7	7	2	1
L:L:?1	R:R:F170	2.92	1	Yes	No	0	1	0	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	9DQH_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	3.39
Number of Linked Nodes	236
Number of Links	257
Number of Hubs	27
Number of Links mediated by Hubs	107
Number of Communities	9
Number of Nodes involved in Communities	50
Number of Links involved in Communities	65

Path Summary
Number Of Nodes in MetaPath	67
Number Of Links MetaPath	66
Number of Shortest Paths	25332
Length Of Smallest Path	3
Average Path Length	12.6024
Length of Longest Path	27
Minimum Path Strength	1.225
Average Path Strength	5.95971
Maximum Path Strength	24.895
Minimum Path Correlation	0.7
Average Path Correlation	0.923861
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	4.7619
Average % Of Corr. Nodes	50.833
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	37.4339
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process	• cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cell communication • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular process • signal transduction • regulation of systemic arterial blood pressure by renin-angiotensin • multicellular organismal process • regulation of systemic arterial blood pressure by hormone • system process • regulation of systemic arterial blood pressure mediated by a chemical signal • negative regulation of blood pressure • renal control of peripheral vascular resistance involved in regulation of systemic arterial blood pressure • circulatory system process • angiotensin-mediated vasodilation involved in regulation of systemic arterial blood pressure • negative regulation of systemic arterial blood pressure • regulation of biological quality • blood vessel diameter maintenance • renal system process involved in regulation of systemic arterial blood pressure • blood circulation • regulation of tube diameter • maintenance of blood vessel diameter homeostasis by renin-angiotensin • renal system process • regulation of blood pressure • regulation of tube size • regulation of systemic arterial blood pressure • endocrine process • vascular process in circulatory system • vasodilation • regulation of anatomical structure size • cell periphery • cellular anatomical structure • plasma membrane • membrane • extracellular region • extracellular space • protein-containing complex binding • binding • G-protein beta/gamma-subunit complex binding • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • cation binding • metal ion binding • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • protein binding • enzyme binding • GTPase binding • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development • anatomical structure development • sensory system development • system development • cell population proliferation • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • response to oxygen-containing compound • cellular response to oxygen-containing compound • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to chemical stimulus • cellular response to alcohol • response to hormone • response to chemical • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • small GTPase-mediated signal transduction • Ras protein signal transduction • intracellular signal transduction • intracellular signaling cassette • phospholipase C-activating G protein-coupled receptor signaling pathway • cellular response to nitrogen compound • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • response to nitrogen compound • cellular response to monoamine stimulus • synaptic signaling • cellular response to acetylcholine • cell-cell signaling • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • extracellular exosome • membrane-bounded organelle • extracellular vesicle • extracellular organelle • organelle • vesicle • extracellular membrane-bounded organelle • non-motile cilium • 9+0 non-motile cilium • cilium • neuron projection • photoreceptor disc membrane • photoreceptor outer segment • plasma membrane bounded cell projection • cell projection • photoreceptor cell cilium • organelle membrane • intracellular anatomical structure • cytoplasm • cytosol • vacuolar membrane • lytic vacuole • vacuole • intracellular membrane-bounded organelle • intracellular organelle • lytic vacuole membrane • bounding membrane of organelle • lysosomal membrane • lysosome • synapse • cell junction • G-protein beta-subunit binding • fibroblast proliferation
Gene Ontology	Cellular Component
SCOP2	Domain Identifier	• Transducin (heterotrimeric G protein), gamma chain
SCOP2	Family Identifier	• Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	A1B
PDB Residues	L:L:?1
Environment Details	Open EMBL-EBI Page
Code	A1B
Name	1-deoxy-alpha-L-xylulofuranose-1,2-borate
Synonyms
Identifier
Formula	C5 H10 B O6
Molecular Weight	176.94
SMILES
PubChem	118797262
Formal Charge	-1
Total Atoms	22
Total Chiral Atoms	3
Total Bonds	23
Total Aromatic Bonds	0


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	Q8TDS7
Sequence	>9DQH_nogp_Chain_R S T V H T A Y L V L S S L A M F T C L C G M A G N S M V I W L L P F C I Y I L N L A A A D L L F L F S M A S T L S L E T Q P L V N T T D K V H E L M K R L M Y F A Y T V G L S L L T A I S T Q R C L S V L F P I W F K C H R P R H L S A W V C G L L W T L C L L M N G L T S S F C S K F L K F N E D R C F R V D M V Q A A L I M G V L T P V M T L S S L T L F V W V R R S S Q Q W R R Q P T R L F V V V L A S V L V F L I C S L P L S I Y W F V L Y W L S L P P E M Q V L C F S L S R L S S S V S S S A N P V I Y F L V Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	9DQJ	A	Orphan	Orphan	MRGPRD	Homo sapiens	EP-3945	-	chim(NtGi1-Gs-CtGq)/β1/γ2	2.9	2024-12-11	10.1016/j.celrep.2024.114942
	9DQJ (No Gprot)	A	Orphan	Orphan	MRGPRD	Homo sapiens	EP-3945	-		2.9	2024-12-11	10.1016/j.celrep.2024.114942
	9DQH	A	Orphan	Orphan	MRGPRD	Homo sapiens	EP-2825	-	chim(NtGi1-Gs-CtGq)/β1/γ2	2.92	2024-12-11	10.1016/j.celrep.2024.114942
	9DQH (No Gprot)	A	Orphan	Orphan	MRGPRD	Homo sapiens	EP-2825	-		2.92	2024-12-11	10.1016/j.celrep.2024.114942
	7Y14	A	Orphan	Orphan	MRGPRD	Homo sapiens	β-Alanine	-	-	3.2	2022-07-20	10.1038/s42003-022-03668-3
	7Y13	A	Orphan	Orphan	MRGPRD	Homo sapiens	-	-	-	3.1	2022-07-20	10.1038/s42003-022-03668-3
	7Y15	A	Orphan	Orphan	MRGPRD	Homo sapiens	-	-	Gi1/β1/γ2	2.9	2022-07-20	10.1038/s42003-022-03668-3
	7Y15 (No Gprot)	A	Orphan	Orphan	MRGPRD	Homo sapiens	-	-		2.9	2022-07-20	10.1038/s42003-022-03668-3
	7Y12	A	Orphan	Orphan	MRGPRD	Homo sapiens	β-Alanine	-	Gi1/β1/γ2	3.1	2022-07-20	10.1038/s42003-022-03668-3
	7Y12 (No Gprot)	A	Orphan	Orphan	MRGPRD	Homo sapiens	β-Alanine	-		3.1	2022-07-20	10.1038/s42003-022-03668-3

You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download 9DQH_nogp.zip

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