psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:Y106	15.47	Yes	Yes	1	0	3
2	L:L:?1	R:R:F170	3.21	Yes	No	0	0	1
3	L:L:?1	R:R:D179	15.22	Yes	No	1	0	3
4	L:L:?1	R:R:Q182	7.9	Yes	Yes	1	0	6
5	L:L:?1	R:R:A183	4.16	Yes	No	0	0	5
6	L:L:?1	R:R:S238	3.96	Yes	No	0	0	7
7	L:L:?1	R:R:W241	27.8	Yes	Yes	1	0	4
8	L:L:?1	R:R:F242	3.21	Yes	No	0	0	5
9	L:L:?1	R:R:Y245	9.28	Yes	Yes	1	0	4
10	R:R:L256	R:R:V23	5.96	No	No	0	2	1
11	R:R:V255	R:R:Y27	11.36	No	No	0	1	3
12	R:R:L28	R:R:S31	6.01	No	No	0	4	3
13	R:R:L28	R:R:S32	4.5	No	No	0	4	5
14	R:R:L30	R:R:S259	7.51	No	No	0	5	3
15	R:R:L263	R:R:L33	4.15	No	No	0	5	5
16	R:R:F36	R:R:M35	3.73	No	Yes	0	5	4
17	R:R:S266	R:R:T37	6.4	No	No	0	6	7
18	R:R:S270	R:R:T37	3.2	No	No	0	8	7
19	R:R:C38	R:R:L76	3.17	Yes	No	0	6	7
20	R:R:C38	R:R:M79	3.24	Yes	No	0	6	5
21	R:R:A80	R:R:C38	3.61	No	Yes	0	6	6
22	R:R:M42	R:R:S46	4.6	No	No	0	7	6
23	R:R:D72	R:R:N45	6.73	Yes	No	0	9	9
24	R:R:L73	R:R:N45	9.61	No	No	0	7	9
25	R:R:N45	R:R:P273	4.89	No	No	0	9	9
26	R:R:L73	R:R:S46	7.51	No	No	0	7	6
27	R:R:L51	R:R:M47	11.31	No	No	0	7	6
28	R:R:A69	R:R:V48	3.39	No	No	0	9	9
29	R:R:F277	R:R:V48	5.24	No	No	0	7	9
30	R:R:A69	R:R:I49	3.25	No	No	0	9	7
31	R:R:F277	R:R:L51	3.65	No	No	0	7	7
32	R:R:L52	R:R:L66	9.69	No	No	0	8	8
33	R:R:C62	R:R:P60	3.77	No	No	0	8	7
34	R:R:F61	R:R:I65	12.56	Yes	No	0	8	8
35	R:R:F61	R:R:I119	8.79	Yes	Yes	3	8	9
36	R:R:F61	R:R:Q122	3.51	Yes	Yes	3	8	9
37	R:R:F61	R:R:R123	5.34	Yes	No	3	8	9
38	R:R:I63	R:R:N67	4.25	No	No	0	7	9
39	R:R:I63	R:R:S142	9.29	No	No	0	7	9
40	R:R:A118	R:R:Y64	5.34	No	Yes	0	8	8
41	R:R:I119	R:R:Y64	4.84	Yes	Yes	0	9	8
42	R:R:Q122	R:R:Y64	9.02	Yes	Yes	0	9	8
43	R:R:S142	R:R:Y64	13.99	No	Yes	0	9	8
44	R:R:V145	R:R:Y64	3.79	No	Yes	0	6	8
45	R:R:C146	R:R:Y64	4.03	No	Yes	0	7	8
46	R:R:I65	R:R:Y276	3.63	No	Yes	0	8	9
47	R:R:C146	R:R:N67	11.02	No	No	0	7	9
48	R:R:N67	R:R:W150	5.65	No	No	0	9	9
49	R:R:D72	R:R:L68	9.5	Yes	No	4	9	9
50	R:R:L68	R:R:N272	6.87	No	No	4	9	9
51	R:R:A71	R:R:V111	3.39	No	Yes	0	9	7
52	R:R:D72	R:R:S269	5.89	Yes	No	0	9	9
53	R:R:D72	R:R:N272	6.73	Yes	No	4	9	9
54	R:R:L104	R:R:L74	4.15	No	No	0	5	6
55	R:R:A108	R:R:L74	4.73	No	No	0	7	6
56	R:R:F75	R:R:M105	3.73	No	Yes	0	6	4
57	R:R:A108	R:R:F75	4.16	No	No	0	7	6
58	R:R:F75	R:R:Y109	5.16	No	Yes	0	6	8
59	R:R:L76	R:R:S269	10.51	No	No	0	7	9
60	R:R:F77	R:R:S81	7.93	No	No	0	4	5
61	R:R:M105	R:R:M79	5.78	Yes	No	0	4	5
62	R:R:M79	R:R:R262	4.96	No	Yes	0	5	4
63	R:R:M101	R:R:S81	4.6	No	No	0	4	5
64	R:R:E86	R:R:T82	5.64	Yes	No	0	3	3
65	R:R:E86	R:R:L83	6.63	Yes	No	5	3	6
66	R:R:L83	R:R:R262	17.01	No	Yes	5	6	4
67	R:R:L85	R:R:T94	4.42	No	No	0	3	1
68	R:R:H98	R:R:L85	6.43	No	No	0	5	3
69	R:R:E86	R:R:H98	4.92	Yes	No	0	3	5
70	R:R:E86	R:R:R262	5.82	Yes	Yes	5	3	4
71	R:R:Q88	R:R:T94	9.92	No	No	0	4	1
72	R:R:D95	R:R:L90	8.14	No	No	0	1	1
73	R:R:T94	R:R:V91	9.52	No	No	0	1	4
74	R:R:D95	R:R:F167	3.58	No	No	0	1	1
75	R:R:E99	R:R:R103	8.14	No	Yes	6	5	4
76	R:R:E99	R:R:S165	10.06	No	No	6	5	3
77	R:R:E99	R:R:F167	3.5	No	No	0	5	1
78	R:R:K102	R:R:R103	8.66	No	Yes	0	3	4
79	R:R:K102	R:R:Y106	8.36	No	Yes	0	3	3
80	R:R:R103	R:R:S161	5.27	Yes	No	0	4	3
81	R:R:R103	R:R:S165	6.59	Yes	No	6	4	3
82	R:R:M105	R:R:Y106	8.38	Yes	Yes	0	4	3
83	R:R:W241	R:R:Y106	7.72	Yes	Yes	1	4	3
84	R:R:F107	R:R:V111	5.24	Yes	Yes	1	5	7
85	R:R:F107	R:R:W150	6.01	Yes	No	1	5	9
86	R:R:F107	R:R:N157	9.67	Yes	No	1	5	7
87	R:R:L113	R:R:Y109	7.03	No	Yes	0	8	8
88	R:R:L237	R:R:Y109	11.72	No	Yes	0	5	8
89	R:R:S238	R:R:Y109	5.09	No	Yes	0	7	8
90	R:R:C153	R:R:T110	5.07	No	No	0	8	6
91	R:R:N157	R:R:T110	10.24	No	No	1	7	6
92	R:R:Q182	R:R:T110	5.67	Yes	No	1	6	6
93	R:R:V111	R:R:W150	17.16	Yes	No	1	7	9
94	R:R:C153	R:R:V111	5.12	No	Yes	0	8	7
95	R:R:F230	R:R:L113	4.87	Yes	No	0	9	8
96	R:R:L149	R:R:S114	6.01	No	No	0	7	7
97	R:R:C153	R:R:S114	3.44	No	No	0	8	7
98	R:R:L190	R:R:S114	4.5	Yes	No	0	8	7
99	R:R:F230	R:R:L116	4.87	Yes	No	0	9	9
100	R:R:L116	R:R:Y276	5.86	No	Yes	0	9	9
101	R:R:L190	R:R:T117	7.37	Yes	No	0	8	8
102	R:R:T117	R:R:V193	3.17	No	No	0	8	6
103	R:R:I119	R:R:R123	3.76	Yes	No	3	9	9
104	R:R:I119	R:R:Y276	6.04	Yes	Yes	0	9	9
105	R:R:M194	R:R:S120	6.13	No	No	0	8	9
106	R:R:S120	R:R:S197	4.89	No	No	0	9	8
107	R:R:S120	R:R:S198	4.89	No	No	0	9	8
108	R:R:S197	R:R:T121	3.2	No	No	0	8	6
109	R:R:F133	R:R:Q122	4.68	No	Yes	3	7	9
110	R:R:Q122	R:R:R137	3.5	Yes	Yes	3	9	9
111	R:R:C124	R:R:L128	4.76	No	Yes	7	8	6
112	R:R:C124	R:R:S197	5.16	No	No	0	8	8
113	R:R:C124	R:R:T200	3.38	No	No	7	8	5
114	R:R:L125	R:R:W132	3.42	No	No	0	6	6
115	R:R:F133	R:R:S126	7.93	No	No	0	7	8
116	R:R:L201	R:R:V127	4.47	No	No	0	8	8
117	R:R:V127	R:R:V205	4.81	No	No	0	8	6
118	R:R:F129	R:R:L128	3.65	No	Yes	0	5	6
119	R:R:L128	R:R:T200	4.42	Yes	No	7	6	5
120	R:R:L128	R:R:W204	12.53	Yes	No	0	6	6
121	R:R:R137	R:R:W132	10	Yes	No	0	9	6
122	R:R:F133	R:R:R137	9.62	No	Yes	3	7	9
123	R:R:C135	R:R:K134	3.23	No	No	0	7	7
124	R:R:C135	R:R:H136	7.37	No	No	0	7	6
125	R:R:L141	R:R:R137	6.07	No	Yes	0	5	9
126	R:R:L141	R:R:P138	3.28	No	No	0	5	8
127	R:R:H140	R:R:R139	9.03	No	No	0	5	5
128	R:R:H140	R:R:W144	4.23	No	No	0	5	5
129	R:R:M156	R:R:Q182	12.23	No	Yes	0	4	6
130	R:R:N157	R:R:Q182	7.92	No	Yes	1	7	6
131	R:R:G158	R:R:S161	3.71	No	No	0	4	3
132	R:R:F163	R:R:L159	7.31	No	No	0	4	6
133	R:R:T160	R:R:V178	11.11	No	No	0	4	4
134	R:R:Q182	R:R:T160	5.67	Yes	No	0	6	4
135	R:R:K169	R:R:S162	4.59	No	No	0	1	3
136	R:R:F163	R:R:R174	9.62	No	No	0	4	1
137	R:R:C164	R:R:C175	7.28	No	No	0	6	8
138	R:R:N171	R:R:R174	7.23	No	No	0	5	1
139	R:R:D173	R:R:E172	3.9	No	No	0	3	3
140	R:R:D173	R:R:R174	4.76	No	No	0	3	1
141	R:R:D173	R:R:R177	19.06	No	No	0	3	3
142	R:R:F176	R:R:M180	11.2	No	No	0	2	3
143	R:R:D179	R:R:Y245	11.49	No	Yes	1	3	4
144	R:R:G188	R:R:P192	4.06	No	No	0	5	5
145	R:R:P192	R:R:T191	3.5	No	No	0	5	5
146	R:R:F230	R:R:T191	6.49	Yes	No	0	9	5
147	R:R:L235	R:R:T191	7.37	No	No	0	6	5
148	R:R:F230	R:R:M194	12.44	Yes	No	0	9	8
149	R:R:L231	R:R:T195	4.42	No	No	0	8	4
150	R:R:S198	R:R:V223	3.23	No	No	0	8	8
151	R:R:S198	R:R:V227	3.23	No	No	0	8	8
152	R:R:L201	R:R:L219	4.15	No	No	0	8	7
153	R:R:F202	R:R:R206	11.76	No	No	2	5	5
154	R:R:F202	R:R:F220	15	No	Yes	2	5	5
155	R:R:F202	R:R:L224	3.65	No	No	0	5	5
156	R:R:L219	R:R:V205	7.45	No	No	0	7	6
157	R:R:F220	R:R:R206	5.34	Yes	No	2	5	5
158	R:R:S209	R:R:W212	4.94	No	Yes	2	7	3
159	R:R:Q215	R:R:S209	8.66	No	No	2	5	7
160	R:R:P216	R:R:S209	5.34	Yes	No	2	7	7
161	R:R:Q211	R:R:W212	4.38	No	Yes	0	5	3
162	R:R:P216	R:R:W212	10.81	Yes	Yes	2	7	3
163	R:R:P216	R:R:Q215	4.74	Yes	No	2	7	5
164	R:R:F220	R:R:P216	4.33	Yes	Yes	2	5	7
165	R:R:S226	R:R:Y276	8.9	No	Yes	0	7	9
166	R:R:S268	R:R:V229	3.23	Yes	No	0	9	7
167	R:R:C233	R:R:S264	3.44	No	No	0	7	7
168	R:R:C233	R:R:V267	3.42	No	No	0	7	5
169	R:R:C233	R:R:S268	3.44	No	Yes	0	7	9
170	R:R:S234	R:R:S268	6.52	No	Yes	0	7	9
171	R:R:P236	R:R:S261	3.56	No	No	0	9	5
172	R:R:W241	R:R:Y240	9.65	Yes	Yes	1	4	3
173	R:R:L244	R:R:Y240	9.38	No	Yes	1	3	3
174	R:R:Q254	R:R:Y240	7.89	No	Yes	1	2	3
175	R:R:F258	R:R:Y240	8.25	No	Yes	0	3	3
176	R:R:L244	R:R:W241	4.56	No	Yes	1	3	4
177	R:R:L247	R:R:V243	4.47	No	No	0	3	5
178	R:R:L244	R:R:Q254	6.65	No	No	1	3	2
179	R:R:W246	R:R:Y245	3.86	No	Yes	0	4	4
180	R:R:L249	R:R:P250	4.93	No	No	0	3	1
181	R:R:L249	R:R:M253	4.24	No	No	0	3	1
182	R:R:E252	R:R:P251	6.29	No	No	0	2	2
183	R:R:F258	R:R:R262	4.28	No	Yes	0	3	4
184	R:R:R262	R:R:S259	3.95	Yes	No	0	4	3
185	R:R:N272	R:R:S268	4.47	No	Yes	0	9	9
186	R:R:A271	R:R:I275	3.25	No	No	0	7	8
187	R:R:I275	R:R:Y276	4.84	No	Yes	0	8	9
188	R:R:P89	R:R:Q88	3.16	No	No	0	3	4
189	L:L:?1	R:R:C164	3.14	Yes	No	0	0	6
190	R:R:I186	R:R:S238	3.1	No	No	0	7	7
191	R:R:R262	R:R:Y27	3.09	Yes	No	0	4	3
192	R:R:M101	R:R:V97	3.04	No	No	0	4	5
193	R:R:M101	R:R:T82	3.01	No	No	0	4	3
194	R:R:L168	R:R:S165	3	No	No	0	1	3
195	R:R:L237	R:R:S265	3	No	No	0	5	8
196	R:R:L33	R:R:V29	2.98	No	No	0	5	4
197	R:R:L128	R:R:V127	2.98	Yes	No	0	6	8
198	R:R:L159	R:R:V178	2.98	No	No	0	6	4
199	R:R:L190	R:R:V189	2.98	Yes	No	0	8	5
200	R:R:L224	R:R:V223	2.98	No	No	0	5	8
201	R:R:L231	R:R:V227	2.98	No	No	0	8	8
202	R:R:I186	R:R:M187	2.92	No	No	0	7	7
203	R:R:I49	R:R:L73	2.85	No	No	0	7	7
204	R:R:I232	R:R:L228	2.85	No	No	0	5	6
205	R:R:L39	R:R:M35	2.83	No	Yes	0	6	4
206	R:R:L260	R:R:L30	2.77	No	No	0	4	5
207	R:R:A34	R:R:R262	2.77	No	Yes	0	6	4
208	R:R:L100	R:R:L104	2.77	No	No	0	4	5
209	R:R:L115	R:R:L149	2.77	No	No	0	7	7
210	R:R:L185	R:R:L190	2.77	No	Yes	0	5	8
211	R:R:F220	R:R:T217	2.59	Yes	No	0	5	5
212	R:R:F107	R:R:L154	2.44	Yes	No	0	5	4
213	R:R:M180	R:R:Y245	2.39	No	Yes	0	3	4
214	R:R:Q210	R:R:R207	2.34	No	No	0	5	5
215	R:R:H136	R:R:W132	2.12	No	No	0	6	6
216	R:R:R214	R:R:W212	2	No	Yes	0	4	3
217	R:R:C40	R:R:G41	1.96	No	No	0	6	9
218	R:R:C146	R:R:G147	1.96	No	No	0	7	5
219	R:R:A43	R:R:G44	1.95	No	No	0	5	9
220	R:R:P250	R:R:P251	1.95	No	No	0	1	2
221	R:R:G41	R:R:S270	1.86	No	No	0	9	8
222	R:R:G112	R:R:V111	1.84	No	Yes	0	9	7
223	R:R:P236	R:R:S264	1.78	No	No	0	9	7
224	R:R:G44	R:R:M47	1.75	No	No	0	9	6
225	R:R:C38	R:R:S266	1.72	Yes	No	0	6	6
226	R:R:A271	R:R:V274	1.7	No	No	0	7	6
227	R:R:C135	R:R:I131	1.64	No	No	0	7	7
228	R:R:A70	R:R:I49	1.62	No	No	0	5	7
229	R:R:S226	R:R:V222	1.62	No	No	0	7	7
230	R:R:A80	R:R:M35	1.61	No	Yes	0	6	4
231	R:R:V23	R:R:V255	1.6	No	No	0	1	1
232	R:R:V222	R:R:V279	1.6	No	No	8	7	7
233	R:R:T25	R:R:V29	1.59	No	No	0	2	4
234	R:R:C62	R:R:L52	1.59	No	No	0	8	8
235	R:R:C257	R:R:L249	1.59	No	No	0	4	3
236	R:R:A26	R:R:L256	1.58	No	No	0	3	2
237	R:R:P60	R:R:Q122	1.58	No	Yes	0	7	9
238	R:R:I239	R:R:V243	1.54	No	No	0	6	5
239	R:R:M35	R:R:S84	1.53	Yes	No	0	4	5
240	R:R:M105	R:R:S78	1.53	Yes	No	0	4	5
241	R:R:M156	R:R:V181	1.52	No	No	0	4	3
242	R:R:L83	R:R:S31	1.5	No	No	0	6	3
243	R:R:L33	R:R:S32	1.5	No	No	0	5	5
244	R:R:L263	R:R:S266	1.5	No	No	0	5	6
245	R:R:A143	R:R:H140	1.46	No	No	0	5	5
246	R:R:I239	R:R:M187	1.46	No	No	0	6	7
247	R:R:F129	R:R:P130	1.44	No	No	0	5	9
248	R:R:E252	R:R:V23	1.43	No	No	0	2	1
249	R:R:Q88	R:R:T87	1.42	No	No	0	4	4
250	R:R:K169	R:R:L168	1.41	No	No	0	1	1
251	R:R:P138	R:R:W144	1.35	No	No	0	8	5
252	R:R:R218	R:R:V222	1.31	No	No	8	7	7
253	R:R:R218	R:R:V279	1.31	No	No	8	7	7
254	R:R:Q210	R:R:Q211	1.28	No	No	0	5	5
255	R:R:V203	R:R:W204	1.23	No	No	0	5	6
256	R:R:F277	R:R:L278	1.22	No	No	0	7	7

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	L:L:?1	9.335	10	1	0
2	R:R:M35	2.425	4	0	4
3	R:R:C38	2.935	4	0	6
4	R:R:F61	7.55	4	3	8
5	R:R:Y64	6.835	6	0	8
6	R:R:D72	7.2125	4	4	9
7	R:R:E86	5.7525	4	5	3
8	R:R:R103	7.165	4	6	4
9	R:R:M105	4.855	4	0	4
10	R:R:Y106	9.9825	4	1	3
11	R:R:F107	5.84	4	1	5
12	R:R:Y109	7.25	4	0	8
13	R:R:V111	6.55	5	1	7
14	R:R:I119	5.8575	4	3	9
15	R:R:Q122	4.458	5	3	9
16	R:R:L128	5.668	5	7	6
17	R:R:R137	7.2975	4	3	9
18	R:R:Q182	7.878	5	1	6
19	R:R:L190	4.405	4	0	8
20	R:R:W212	5.5325	4	2	3
21	R:R:P216	6.305	4	2	7
22	R:R:F220	6.815	4	2	5
23	R:R:F230	7.1675	4	0	9
24	R:R:Y240	8.7925	4	1	3
25	R:R:W241	12.4325	4	1	4
26	R:R:Y245	6.755	4	1	4
27	R:R:R262	5.98286	7	5	4
28	R:R:S268	4.415	4	0	9
29	R:R:Y276	5.854	5	0	9

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:Y106	39.6873	15.47	Yes	Yes	1	0	3
2	R:R:M105	R:R:Y106	41.2379	8.38	Yes	Yes	0	4	3
3	R:R:M105	R:R:M79	100	5.78	Yes	No	0	4	5
4	R:R:M79	R:R:R262	51.2398	4.96	No	Yes	0	5	4
5	R:R:R262	R:R:Y27	22.6501	3.09	Yes	No	0	4	3
6	R:R:V255	R:R:Y27	20.8881	11.36	No	No	0	1	3
7	R:R:V23	R:R:V255	19.062	1.6	No	No	0	1	1
8	L:L:?1	R:R:W241	15.8775	27.8	Yes	Yes	1	0	4
9	R:R:W241	R:R:Y240	14.0065	9.65	Yes	Yes	1	4	3
10	R:R:F258	R:R:Y240	13.6605	8.25	No	Yes	0	3	3
11	R:R:F258	R:R:R262	13.6605	4.28	No	Yes	0	3	4
12	R:R:C38	R:R:M79	67.0597	3.24	Yes	No	0	6	5
13	R:R:C38	R:R:S266	17.1718	1.72	Yes	No	0	6	6
14	R:R:C38	R:R:L76	46.1011	3.17	Yes	No	0	6	7
15	R:R:L76	R:R:S269	44.6274	10.51	No	No	0	7	9
16	R:R:D72	R:R:S269	43.1409	5.89	Yes	No	0	9	9
17	R:R:D72	R:R:N45	25.9435	6.73	Yes	No	0	9	9
18	R:R:L73	R:R:N45	22.6501	9.61	No	No	0	7	9
19	R:R:I49	R:R:L73	17.6139	2.85	No	No	0	7	7
20	R:R:A69	R:R:I49	14.1924	3.25	No	No	0	9	7
21	R:R:A69	R:R:V48	12.4624	3.39	No	No	0	9	9
22	R:R:F277	R:R:V48	10.7195	5.24	No	No	0	7	9
23	L:L:?1	R:R:Q182	50.6503	7.9	Yes	Yes	1	0	6
24	R:R:N157	R:R:Q182	20.8368	7.92	No	Yes	1	7	6
25	R:R:F107	R:R:N157	20.2217	9.67	Yes	No	1	5	7
26	R:R:F107	R:R:W150	13.8976	6.01	Yes	No	1	5	9
27	R:R:N67	R:R:W150	17.6908	5.65	No	No	0	9	9
28	R:R:C146	R:R:N67	14.6152	11.02	No	No	0	7	9
29	R:R:C146	R:R:Y64	13.4235	4.03	No	Yes	0	7	8
30	R:R:Q122	R:R:Y64	27.0584	9.02	Yes	Yes	0	9	8
31	R:R:P60	R:R:Q122	13.2376	1.58	No	Yes	0	7	9
32	L:L:?1	R:R:S238	28.2117	3.96	Yes	No	0	0	7
33	R:R:S238	R:R:Y109	29.2561	5.09	No	Yes	0	7	8
34	R:R:L113	R:R:Y109	93.7464	7.03	No	Yes	0	8	8
35	R:R:F230	R:R:L113	93.4324	4.87	Yes	No	0	9	8
36	R:R:F230	R:R:L116	72.9352	4.87	Yes	No	0	9	9
37	R:R:L116	R:R:Y276	72.2625	5.86	No	Yes	0	9	9
38	R:R:I65	R:R:Y276	20.6894	3.63	No	Yes	0	8	9
39	R:R:F61	R:R:I65	19.7155	12.56	Yes	No	0	8	8
40	R:R:I119	R:R:Y276	46.729	6.04	Yes	Yes	0	9	9
41	R:R:F61	R:R:I119	19.786	8.79	Yes	Yes	3	8	9
42	R:R:D72	R:R:N272	15.8519	6.73	Yes	No	4	9	9
43	R:R:Q182	R:R:T110	17.8317	5.67	Yes	No	1	6	6
44	R:R:C153	R:R:T110	16.9219	5.07	No	No	0	8	6
45	R:R:F75	R:R:M105	73.6593	3.73	No	Yes	0	6	4
46	R:R:F75	R:R:Y109	74.6524	5.16	No	Yes	0	6	8
47	R:R:E86	R:R:R262	25.6103	5.82	Yes	Yes	5	3	4
48	R:R:E86	R:R:T82	10.3607	5.64	Yes	No	0	3	3
49	R:R:E86	R:R:H98	14.5127	4.92	Yes	No	0	3	5
50	R:R:H98	R:R:L85	12.7058	6.43	No	No	0	5	3
51	R:R:L85	R:R:T94	10.617	4.42	No	No	0	3	1
52	R:R:K102	R:R:Y106	21.2789	8.36	No	Yes	0	3	3
53	R:R:K102	R:R:R103	19.6771	8.66	No	Yes	0	3	4
54	R:R:C153	R:R:S114	13.731	3.44	No	No	0	8	7
55	R:R:F230	R:R:M194	55.6417	12.44	Yes	No	0	9	8
56	R:R:M194	R:R:S120	54.1808	6.13	No	No	0	8	9
57	R:R:S120	R:R:S197	24.4954	4.89	No	No	0	9	8
58	R:R:S120	R:R:S198	31.3577	4.89	No	No	0	9	8
59	R:R:C124	R:R:S197	21.0482	5.16	No	No	0	8	8
60	R:R:C124	R:R:L128	17.4857	4.76	No	Yes	7	8	6
61	R:R:Q122	R:R:R137	41.6095	3.5	Yes	Yes	3	9	9
62	R:R:R137	R:R:W132	19.8308	10	Yes	No	0	9	6
63	R:R:H136	R:R:W132	13.2697	2.12	No	No	0	6	6
64	R:R:L141	R:R:R137	19.5489	6.07	No	Yes	0	5	9
65	R:R:L141	R:R:P138	16.5567	3.28	No	No	0	5	8
66	R:R:P138	R:R:W144	13.2697	1.35	No	No	0	8	5
67	R:R:Q182	R:R:T160	15.1727	5.67	Yes	No	0	6	4
68	R:R:T160	R:R:V178	13.731	11.11	No	No	0	4	4
69	R:R:L159	R:R:V178	12.0587	2.98	No	No	0	6	4
70	R:R:F163	R:R:L159	10.3736	7.31	No	No	0	4	6
71	R:R:S198	R:R:V223	24.6043	3.23	No	No	0	8	8
72	R:R:L224	R:R:V223	23.1306	2.98	No	No	0	5	8
73	R:R:F202	R:R:L224	21.3814	3.65	No	No	0	5	5
74	R:R:F202	R:R:F220	17.8125	15	No	Yes	2	5	5
75	R:R:F220	R:R:P216	14.3205	4.33	Yes	Yes	2	5	7
76	R:R:N272	R:R:S268	14.1924	4.47	No	Yes	0	9	9
77	R:R:I186	R:R:S238	12.3919	3.1	No	No	0	7	7
78	R:R:E252	R:R:V23	12.8212	1.43	No	No	0	2	1
79	R:R:E252	R:R:P251	10.726	6.29	No	No	0	2	2
80	R:R:I119	R:R:Y64	26.2254	4.84	Yes	Yes	0	9	8
81	R:R:F61	R:R:Q122	36.9642	3.51	Yes	Yes	3	8	9

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:?1	R:R:Y106	15.47	1	Yes	Yes	0	3	0	1
L:L:?1	R:R:F170	3.21	1	Yes	No	0	1	0	1
L:L:?1	R:R:D179	15.22	1	Yes	No	0	3	0	1
L:L:?1	R:R:Q182	7.9	1	Yes	Yes	0	6	0	1
L:L:?1	R:R:A183	4.16	1	Yes	No	0	5	0	1
L:L:?1	R:R:S238	3.96	1	Yes	No	0	7	0	1
L:L:?1	R:R:W241	27.8	1	Yes	Yes	0	4	0	1
L:L:?1	R:R:F242	3.21	1	Yes	No	0	5	0	1
L:L:?1	R:R:Y245	9.28	1	Yes	Yes	0	4	0	1
R:R:K102	R:R:Y106	8.36	0	No	Yes	3	3	2	1
R:R:M105	R:R:Y106	8.38	0	Yes	Yes	4	3	2	1
R:R:W241	R:R:Y106	7.72	1	Yes	Yes	4	3	1	1
R:R:S238	R:R:Y109	5.09	0	No	Yes	7	8	1	2
R:R:N157	R:R:T110	10.24	1	No	No	7	6	2	2
R:R:Q182	R:R:T110	5.67	1	Yes	No	6	6	1	2
R:R:M156	R:R:Q182	12.23	0	No	Yes	4	6	2	1
R:R:N157	R:R:Q182	7.92	1	No	Yes	7	6	2	1
R:R:Q182	R:R:T160	5.67	1	Yes	No	6	4	1	2
R:R:C164	R:R:C175	7.28	0	No	No	6	8	1	2
R:R:D179	R:R:Y245	11.49	1	No	Yes	3	4	1	1
R:R:W241	R:R:Y240	9.65	1	Yes	Yes	4	3	1	2
R:R:L244	R:R:Y240	9.38	1	No	Yes	3	3	2	2
R:R:L244	R:R:W241	4.56	1	No	Yes	3	4	2	1
R:R:W246	R:R:Y245	3.86	0	No	Yes	4	4	2	1
L:L:?1	R:R:C164	3.14	1	Yes	No	0	6	0	1
R:R:I186	R:R:S238	3.1	0	No	No	7	7	2	1
R:R:M180	R:R:Y245	2.39	0	No	Yes	3	4	2	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	9DQJ_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	3.17
Number of Linked Nodes	233
Number of Links	256
Number of Hubs	29
Number of Links mediated by Hubs	115
Number of Communities	8
Number of Nodes involved in Communities	42
Number of Links involved in Communities	50

Path Summary
Number Of Nodes in MetaPath	82
Number Of Links MetaPath	81
Number of Shortest Paths	36451
Length Of Smallest Path	3
Average Path Length	13.3769
Length of Longest Path	32
Minimum Path Strength	1.465
Average Path Strength	5.99913
Maximum Path Strength	21.51
Minimum Path Correlation	0.7
Average Path Correlation	0.923287
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	5.26316
Average % Of Corr. Nodes	47.6248
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	38.9378
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process
Gene Ontology	Cellular Component
SCOP2	Domain Identifier	• Transducin (heterotrimeric G protein), gamma chain
SCOP2	Family Identifier	• Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	_L_
PDB Residues	L:L:?1
Environment Details	Open EMBL-EBI Page
Code	_L_
Name
Synonyms
Identifier
Formula
Molecular Weight
SMILES
PubChem
Formal Charge
Total Atoms
Total Chiral Atoms
Total Bonds
Total Aromatic Bonds


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	Q8TDS7
Sequence	>9DQJ_nogp_Chain_R S T V H T A Y L V L S S L A M F T C L C G M A G N S M V I W L L P F C I Y I L N L A A A D L L F L F S M A S T L S L E T Q P L V N T T D K V H E L M K R L M Y F A Y T V G L S L L T A I S T Q R C L S V L F P I W F K C H R P R H L S A W V C G L L W T L C L L M N G L T S S F C S K F L K F N E D R C F R V D M V Q A A L I M G V L T P V M T L S S L T L F V W V R R S S Q Q W R R Q P T R L F V V V L A S V L V F L I C S L P L S I Y W F V L Y W L S L P P E M Q V L C F S L S R L S S S V S S S A N P V I Y F L V Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	7Y12	A	Orphan	Orphan	MRGPRD	Homo sapiens	β-Alanine	-	Gi1/β1/γ2	3.1	2022-07-20	doi.org/10.1038/s42003-022-03668-3
	7Y12 (No Gprot)	A	Orphan	Orphan	MRGPRD	Homo sapiens	β-Alanine	-		3.1	2022-07-20	doi.org/10.1038/s42003-022-03668-3
	7Y13	A	Orphan	Orphan	MRGPRD	Homo sapiens	-	-	-	3.1	2022-07-20	doi.org/10.1038/s42003-022-03668-3
	7Y14	A	Orphan	Orphan	MRGPRD	Homo sapiens	β-Alanine	-	-	3.2	2022-07-20	doi.org/10.1038/s42003-022-03668-3
	7Y15	A	Orphan	Orphan	MRGPRD	Homo sapiens	-	-	Gi1/β1/γ2	2.9	2022-07-20	doi.org/10.1038/s42003-022-03668-3
	7Y15 (No Gprot)	A	Orphan	Orphan	MRGPRD	Homo sapiens	-	-		2.9	2022-07-20	doi.org/10.1038/s42003-022-03668-3
	9DQH	A	Orphan	Orphan	MRGPRD	Homo sapiens	EP-2825	-	chim(NtGi1-Gs-CtGq)/β1/γ2	2.92	2024-12-11	doi.org/10.1016/j.celrep.2024.114942
	9DQH (No Gprot)	A	Orphan	Orphan	MRGPRD	Homo sapiens	EP-2825	-		2.92	2024-12-11	doi.org/10.1016/j.celrep.2024.114942
	9DQJ	A	Orphan	Orphan	MRGPRD	Homo sapiens	EP-3945	-	chim(NtGi1-Gs-CtGq)/β1/γ2	2.9	2024-12-11	doi.org/10.1016/j.celrep.2024.114942
	9DQJ (No Gprot)	A	Orphan	Orphan	MRGPRD	Homo sapiens	EP-3945	-		2.9	2024-12-11	doi.org/10.1016/j.celrep.2024.114942

You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download 9DQJ_nogp.zip

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