psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:H24	R:R:L28	3.86	No	No	0	1	4
2	R:R:L28	R:R:Y27	3.52	No	Yes	0	4	3
3	R:R:S31	R:R:Y27	8.9	No	Yes	0	3	3
4	R:R:E86	R:R:Y27	5.61	No	Yes	0	3	3
5	R:R:V255	R:R:Y27	5.05	No	Yes	0	1	3
6	R:R:L30	R:R:S259	7.51	No	No	0	5	3
7	R:R:R262	R:R:S31	5.27	Yes	No	0	4	3
8	R:R:L263	R:R:L33	4.15	No	No	0	5	5
9	R:R:L83	R:R:M35	8.48	No	No	0	6	4
10	R:R:S266	R:R:T37	4.8	No	No	0	6	7
11	R:R:T37	R:R:V267	6.35	No	No	0	7	5
12	R:R:C38	R:R:L76	6.35	No	No	0	6	7
13	R:R:G41	R:R:S270	3.71	No	No	0	9	8
14	R:R:F77	R:R:M42	4.98	No	No	0	4	7
15	R:R:D72	R:R:N45	6.73	Yes	No	0	9	9
16	R:R:F277	R:R:V48	7.87	Yes	No	0	7	9
17	R:R:I49	R:R:L66	4.28	No	No	0	7	8
18	R:R:L51	R:R:W50	4.56	No	No	0	7	6
19	R:R:F277	R:R:L51	4.87	Yes	No	0	7	7
20	R:R:L52	R:R:M56	4.24	Yes	Yes	0	8	7
21	R:R:H57	R:R:L52	9	Yes	Yes	4	6	8
22	R:R:L52	R:R:L66	5.54	Yes	No	4	8	8
23	R:R:F277	R:R:L52	3.65	Yes	Yes	0	7	8
24	R:R:F54	R:R:R55	4.28	No	No	0	6	6
25	R:R:M56	R:R:R283	6.2	Yes	Yes	0	7	6
26	R:R:H57	R:R:I63	3.98	Yes	No	0	6	7
27	R:R:H57	R:R:L66	6.43	Yes	No	4	6	8
28	R:R:N59	R:R:P60	6.52	Yes	No	1	8	7
29	R:R:F61	R:R:N59	12.08	Yes	Yes	1	8	8
30	R:R:C62	R:R:N59	4.72	No	Yes	1	8	8
31	R:R:N59	R:R:R283	14.46	Yes	Yes	1	8	6
32	R:R:F133	R:R:P60	5.78	Yes	No	1	7	7
33	R:R:P60	R:R:R137	5.76	No	Yes	1	7	9
34	R:R:F61	R:R:Q122	14.05	Yes	No	1	8	9
35	R:R:F61	R:R:S126	5.28	Yes	No	1	8	8
36	R:R:F133	R:R:F61	7.5	Yes	Yes	1	7	8
37	R:R:C62	R:R:R283	4.18	No	Yes	1	8	6
38	R:R:I63	R:R:S142	7.74	No	No	0	7	9
39	R:R:A118	R:R:Y64	5.34	No	Yes	0	8	8
40	R:R:I119	R:R:Y64	3.63	No	Yes	0	9	8
41	R:R:Q122	R:R:Y64	11.27	No	Yes	0	9	8
42	R:R:S142	R:R:Y64	13.99	No	Yes	0	9	8
43	R:R:V145	R:R:Y64	6.31	No	Yes	0	6	8
44	R:R:C146	R:R:N67	7.87	No	No	0	7	9
45	R:R:D72	R:R:L68	9.5	Yes	No	0	9	9
46	R:R:L115	R:R:L68	4.15	No	No	0	7	9
47	R:R:L116	R:R:L68	5.54	No	No	0	9	9
48	R:R:D72	R:R:S269	8.83	Yes	No	0	9	9
49	R:R:D72	R:R:N272	6.73	Yes	No	0	9	9
50	R:R:A108	R:R:L74	4.73	No	No	0	7	6
51	R:R:F75	R:R:L76	6.09	Yes	No	3	6	7
52	R:R:F75	R:R:M79	3.73	Yes	No	3	6	5
53	R:R:F75	R:R:M105	4.98	Yes	Yes	3	6	4
54	R:R:F75	R:R:Y109	7.22	Yes	Yes	3	6	8
55	R:R:F75	R:R:S265	5.28	Yes	No	3	6	8
56	R:R:F75	R:R:S269	7.93	Yes	No	3	6	9
57	R:R:L76	R:R:S269	4.5	No	No	3	7	9
58	R:R:F77	R:R:M101	3.73	No	No	0	4	4
59	R:R:M105	R:R:S78	4.6	Yes	No	0	4	5
60	R:R:M105	R:R:M79	7.22	Yes	No	3	4	5
61	R:R:M79	R:R:R262	4.96	No	Yes	0	5	4
62	R:R:M101	R:R:S81	9.2	No	No	0	4	5
63	R:R:H98	R:R:T82	4.11	Yes	No	0	5	3
64	R:R:L83	R:R:R262	4.86	No	Yes	0	6	4
65	R:R:H98	R:R:L85	7.71	Yes	No	0	5	3
66	R:R:E86	R:R:H98	3.69	No	Yes	0	3	5
67	R:R:H98	R:R:L90	7.71	Yes	No	0	5	1
68	R:R:N92	R:R:T93	10.24	No	No	0	5	2
69	R:R:D95	R:R:K166	6.91	No	Yes	2	1	3
70	R:R:D95	R:R:F167	9.55	No	Yes	2	1	1
71	R:R:F167	R:R:K96	13.65	Yes	No	0	1	1
72	R:R:H98	R:R:K102	6.55	Yes	No	0	5	3
73	R:R:E99	R:R:R103	11.63	Yes	Yes	2	5	4
74	R:R:E99	R:R:S165	8.62	Yes	Yes	2	5	3
75	R:R:E99	R:R:K166	4.05	Yes	Yes	2	5	3
76	R:R:E99	R:R:F167	5.83	Yes	Yes	2	5	1
77	R:R:K102	R:R:R103	4.95	No	Yes	0	3	4
78	R:R:K102	R:R:Y106	3.58	No	Yes	0	3	3
79	R:R:R103	R:R:S161	9.22	Yes	No	2	4	3
80	R:R:R103	R:R:S165	6.59	Yes	Yes	2	4	3
81	L:L:?1	R:R:R103	5.66	Yes	Yes	2	0	4
82	R:R:M105	R:R:Y106	11.97	Yes	Yes	0	4	3
83	R:R:L237	R:R:Y106	4.69	No	Yes	0	5	3
84	R:R:W241	R:R:Y106	40.51	Yes	Yes	0	4	3
85	R:R:F107	R:R:W150	5.01	No	Yes	0	5	9
86	R:R:F107	R:R:L154	6.09	No	No	0	5	4
87	R:R:F107	R:R:N157	12.08	No	No	0	5	7
88	R:R:L113	R:R:Y109	15.24	No	Yes	0	8	8
89	R:R:L237	R:R:Y109	5.86	No	Yes	3	5	8
90	R:R:S238	R:R:Y109	5.09	No	Yes	0	7	8
91	R:R:S265	R:R:Y109	7.63	No	Yes	3	8	8
92	R:R:N157	R:R:T110	4.39	No	No	0	7	6
93	R:R:V111	R:R:W150	15.94	No	Yes	0	7	9
94	R:R:C153	R:R:V111	6.83	No	No	0	8	7
95	R:R:L149	R:R:S114	10.51	No	No	0	7	7
96	R:R:L116	R:R:N272	6.87	No	No	0	9	9
97	R:R:L116	R:R:Y276	4.69	No	Yes	0	9	9
98	R:R:L190	R:R:T117	8.84	No	No	0	8	8
99	R:R:M194	R:R:T117	4.52	No	No	0	8	8
100	R:R:I119	R:R:Y276	7.25	No	Yes	0	9	9
101	R:R:M194	R:R:S120	7.67	No	No	0	8	9
102	R:R:S197	R:R:T121	6.4	No	No	0	8	6
103	R:R:F133	R:R:Q122	4.68	Yes	No	1	7	9
104	R:R:R123	R:R:Y276	7.2	No	Yes	0	9	9
105	R:R:C124	R:R:S197	5.16	No	No	0	8	8
106	R:R:F133	R:R:S126	7.93	Yes	No	1	7	8
107	R:R:L201	R:R:V127	4.47	No	No	0	8	8
108	R:R:F129	R:R:L128	4.87	No	No	0	5	6
109	R:R:L128	R:R:T200	4.42	No	No	0	6	5
110	R:R:L128	R:R:W204	9.11	No	No	0	6	6
111	R:R:H136	R:R:W132	5.29	No	No	0	6	6
112	R:R:R137	R:R:W132	9	Yes	No	0	9	6
113	R:R:F133	R:R:R137	10.69	Yes	Yes	1	7	9
114	R:R:C135	R:R:H136	7.37	No	No	0	7	6
115	R:R:L141	R:R:R137	7.29	No	Yes	1	5	9
116	R:R:L141	R:R:P138	8.21	No	No	1	5	8
117	R:R:P138	R:R:W144	5.4	No	No	1	8	5
118	R:R:H140	R:R:R139	4.51	No	No	0	5	5
119	R:R:L141	R:R:W144	6.83	No	No	1	5	5
120	R:R:L148	R:R:L152	6.92	No	No	0	5	6
121	R:R:M156	R:R:Q182	6.8	No	Yes	0	4	6
122	R:R:N157	R:R:Q182	3.96	No	Yes	0	7	6
123	R:R:F163	R:R:L159	3.65	Yes	No	0	4	6
124	R:R:T160	R:R:V178	4.76	No	No	0	4	4
125	R:R:Q182	R:R:T160	7.09	Yes	No	0	6	4
126	R:R:S161	R:R:S165	4.89	No	Yes	2	3	3
127	R:R:L168	R:R:S161	4.5	No	No	2	1	3
128	R:R:F163	R:R:S162	5.28	Yes	No	0	4	3
129	R:R:F163	R:R:R174	16.03	Yes	No	0	4	1
130	R:R:F163	R:R:V178	5.24	Yes	No	0	4	4
131	R:R:C164	R:R:C175	7.28	No	No	2	6	8
132	L:L:?1	R:R:C164	9.24	Yes	No	2	0	6
133	R:R:L168	R:R:S165	9.01	No	Yes	2	1	3
134	R:R:F167	R:R:K166	12.41	Yes	Yes	2	1	3
135	R:R:K169	R:R:R174	6.19	No	No	0	1	1
136	R:R:N171	R:R:R174	20.49	No	No	0	5	1
137	R:R:D173	R:R:R177	8.34	No	No	0	3	3
138	R:R:C175	R:R:W246	5.22	No	Yes	0	8	4
139	L:L:?1	R:R:C175	3.69	Yes	No	2	0	8
140	R:R:F176	R:R:M180	12.44	No	No	0	2	3
141	R:R:F176	R:R:W246	22.05	No	Yes	0	2	4
142	R:R:D179	R:R:W246	14.52	No	Yes	0	3	4
143	L:L:?1	R:R:D179	11.06	Yes	No	0	0	3
144	R:R:F242	R:R:Q182	11.71	Yes	Yes	0	5	6
145	R:R:A183	R:R:F242	4.16	No	Yes	0	5	5
146	R:R:I186	R:R:S238	6.19	No	No	0	7	7
147	R:R:F242	R:R:I186	3.77	Yes	No	0	5	7
148	R:R:M187	R:R:T191	7.53	No	No	0	7	5
149	R:R:G188	R:R:P192	4.06	No	No	0	5	5
150	R:R:P192	R:R:T191	5.25	No	No	0	5	5
151	R:R:L235	R:R:T191	4.42	No	No	0	6	5
152	R:R:F230	R:R:M194	16.17	No	No	0	9	8
153	R:R:S198	R:R:V223	4.85	No	No	0	8	8
154	R:R:F202	R:R:F220	17.15	No	Yes	0	5	5
155	R:R:F202	R:R:V223	3.93	No	No	0	5	8
156	R:R:F202	R:R:L224	8.53	No	No	0	5	5
157	R:R:R207	R:R:V203	3.92	No	No	0	5	5
158	R:R:S208	R:R:W204	4.94	No	No	0	5	6
159	R:R:P216	R:R:V205	3.53	No	No	0	7	6
160	R:R:L219	R:R:V205	11.92	No	No	0	7	6
161	R:R:F220	R:R:V205	3.93	Yes	No	0	5	6
162	R:R:Q210	R:R:R206	21.03	No	No	0	5	5
163	R:R:Q215	R:R:R206	7.01	No	No	5	5	5
164	R:R:F220	R:R:R206	6.41	Yes	No	5	5	5
165	R:R:R213	R:R:S209	10.54	No	No	6	5	7
166	R:R:P216	R:R:S209	3.56	No	No	6	7	7
167	R:R:Q210	R:R:Q211	6.4	No	No	0	5	5
168	R:R:Q211	R:R:W212	9.86	No	No	0	5	3
169	R:R:P216	R:R:R213	8.65	No	No	6	7	5
170	R:R:F220	R:R:Q215	4.68	Yes	No	5	5	5
171	R:R:R218	R:R:V279	3.92	No	No	0	7	7
172	R:R:V222	R:R:V279	8.02	No	No	0	7	7
173	R:R:I232	R:R:L228	4.28	No	No	0	5	6
174	R:R:F230	R:R:L231	3.65	No	No	0	9	8
175	R:R:F230	R:R:L235	3.65	No	No	0	9	6
176	R:R:S234	R:R:S268	6.52	No	No	0	7	9
177	R:R:P236	R:R:S261	3.56	No	No	0	9	5
178	R:R:P236	R:R:S264	5.34	No	No	0	9	7
179	R:R:L237	R:R:S265	6.01	No	No	3	5	8
180	R:R:W241	R:R:Y240	3.86	Yes	Yes	0	4	3
181	R:R:L244	R:R:Y240	3.52	No	Yes	0	3	3
182	R:R:Q254	R:R:Y240	6.76	No	Yes	0	2	3
183	R:R:F258	R:R:Y240	14.44	No	Yes	0	3	3
184	R:R:S261	R:R:Y240	3.82	No	Yes	0	5	3
185	R:R:F242	R:R:W241	8.02	Yes	Yes	0	5	4
186	L:L:?1	R:R:W241	21.21	Yes	Yes	0	0	4
187	R:R:W246	R:R:Y245	13.5	Yes	No	0	4	4
188	L:L:?1	R:R:Y245	17.74	Yes	No	0	0	4
189	R:R:L249	R:R:M253	5.65	No	No	0	3	1
190	R:R:F258	R:R:R262	16.03	No	Yes	0	3	4
191	R:R:R262	R:R:S259	3.95	Yes	No	0	4	3
192	R:R:N272	R:R:S268	4.47	No	No	0	9	9
193	R:R:I275	R:R:Y276	3.63	No	Yes	0	8	9
194	R:R:F277	R:R:L278	3.65	Yes	No	0	7	7
195	R:R:S281	R:R:S284	4.89	No	No	0	7	5
196	R:R:H285	R:R:S281	9.76	No	No	0	4	7
197	R:R:R282	R:R:R283	5.33	No	Yes	0	5	6
198	R:R:C38	R:R:S266	3.44	No	No	0	6	6
199	R:R:C233	R:R:S268	3.44	No	No	0	7	9
200	R:R:C233	R:R:V229	3.42	No	No	0	7	7
201	R:R:A69	R:R:V48	3.39	No	No	0	9	9
202	R:R:N67	R:R:W150	3.39	No	Yes	0	9	9
203	R:R:C124	R:R:T200	3.38	No	No	0	8	5
204	R:R:M253	R:R:P250	3.35	No	No	0	1	1
205	R:R:N45	R:R:P273	3.26	No	No	0	9	9
206	R:R:C257	R:R:M253	3.24	No	No	0	4	1
207	R:R:S32	R:R:V29	3.23	No	No	0	5	4
208	R:R:S114	R:R:V111	3.23	No	No	0	7	7
209	R:R:S126	R:R:V127	3.23	No	No	0	8	8
210	R:R:S198	R:R:V227	3.23	No	No	0	8	8
211	R:R:S226	R:R:V227	3.23	No	No	0	7	8
212	R:R:A80	R:R:M35	3.22	No	No	0	6	4
213	R:R:S270	R:R:T37	3.2	No	No	0	8	7
214	R:R:T22	R:R:V23	3.17	No	No	0	1	1
215	R:R:T117	R:R:V193	3.17	No	No	0	8	6
216	R:R:H140	R:R:W144	3.17	No	No	0	5	5
217	R:R:P89	R:R:Q88	3.16	No	No	0	3	4
218	R:R:M101	R:R:V97	3.04	No	No	0	4	5
219	R:R:M156	R:R:V181	3.04	No	No	0	4	3
220	R:R:L73	R:R:S46	3	No	No	0	7	6
221	R:R:L74	R:R:S78	3	No	No	0	6	5
222	R:R:L256	R:R:V23	2.98	No	No	0	2	1
223	R:R:L190	R:R:V189	2.98	No	No	0	8	5
224	R:R:L201	R:R:V223	2.98	No	No	0	8	8
225	R:R:L231	R:R:V227	2.98	No	No	0	8	8
226	R:R:N92	R:R:V91	2.96	No	No	0	5	4
227	R:R:L85	R:R:T94	2.95	No	No	0	3	1
228	R:R:L90	R:R:T94	2.95	No	No	0	1	1
229	R:R:L125	R:R:T121	2.95	No	No	0	6	6
230	R:R:A143	R:R:H140	2.93	No	No	0	5	5
231	R:R:I239	R:R:M187	2.92	No	No	0	6	7
232	R:R:I49	R:R:L73	2.85	No	No	0	7	7
233	R:R:L73	R:R:M42	2.83	No	No	0	7	7
234	R:R:C40	R:R:F36	2.79	No	No	0	6	5
235	R:R:L260	R:R:L30	2.77	No	No	0	4	5
236	R:R:A71	R:R:W150	2.59	No	Yes	0	9	9
237	R:R:M56	R:R:R55	2.48	Yes	No	0	7	6
238	R:R:C146	R:R:G147	1.96	No	No	0	7	5
239	R:R:A43	R:R:G44	1.95	No	No	0	5	9
240	R:R:A71	R:R:G112	1.95	No	No	0	9	9
241	R:R:P250	R:R:P251	1.95	No	No	0	1	2
242	R:R:P89	R:R:V91	1.77	No	No	0	3	4
243	R:R:C40	R:R:S270	1.72	No	No	0	6	8
244	R:R:A183	R:R:V243	1.7	No	No	0	5	5
245	R:R:I131	R:R:P130	1.69	No	No	0	7	9
246	R:R:C135	R:R:I131	1.64	No	No	0	7	7
247	R:R:C233	R:R:I232	1.64	No	No	0	7	5
248	R:R:S197	R:R:V193	1.62	No	No	0	8	6
249	R:R:A225	R:R:I275	1.62	No	No	0	6	8
250	R:R:V221	R:R:V222	1.6	No	No	0	6	7
251	R:R:G53	R:R:H57	1.59	No	Yes	0	6	6
252	R:R:A26	R:R:L30	1.58	No	No	0	3	5
253	R:R:A34	R:R:L83	1.58	No	No	0	6	6
254	R:R:A34	R:R:L263	1.58	No	No	0	6	5
255	R:R:E252	R:R:P251	1.57	No	No	0	2	2
256	R:R:I65	R:R:V48	1.54	No	No	0	8	9
257	R:R:M35	R:R:S84	1.53	No	No	0	4	5
258	R:R:M56	R:R:S284	1.53	Yes	No	0	7	5
259	R:R:L33	R:R:S32	1.5	No	No	0	5	5
260	R:R:L104	R:R:S78	1.5	No	No	0	5	5
261	R:R:L196	R:R:T195	1.47	No	No	0	4	4
262	R:R:L231	R:R:T195	1.47	No	No	0	8	4
263	R:R:I186	R:R:L185	1.43	No	No	0	7	5
264	R:R:Q215	R:R:T217	1.42	No	No	0	5	5
265	R:R:L100	R:R:L104	1.38	No	No	0	4	5
266	R:R:L247	R:R:L249	1.38	No	No	0	3	3
267	R:R:C257	R:R:Y240	1.34	No	Yes	0	4	3
268	R:R:E172	R:R:N171	1.31	No	No	0	3	5
269	R:R:F170	R:R:K166	1.24	No	Yes	0	1	3
270	R:R:F176	R:R:R177	1.07	No	No	0	2	3

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	R:R:Y27	5.77	4	0	3
2	R:R:L52	5.6075	4	4	8
3	R:R:M56	3.6125	4	0	7
4	R:R:H57	5.25	4	4	6
5	R:R:N59	9.445	4	1	8
6	R:R:F61	9.7275	4	1	8
7	R:R:Y64	8.108	5	0	8
8	R:R:D72	7.9475	4	0	9
9	R:R:F75	5.87167	6	3	6
10	R:R:H98	5.954	5	0	5
11	R:R:E99	7.5325	4	2	5
12	R:R:R103	7.61	5	2	4
13	R:R:M105	7.1925	4	3	4
14	R:R:Y106	15.1875	4	0	3
15	R:R:Y109	8.208	5	3	8
16	R:R:F133	7.316	5	1	7
17	R:R:R137	8.185	4	1	9
18	R:R:W150	6.7325	4	0	9
19	R:R:F163	7.55	4	0	4
20	R:R:S165	7.2775	4	2	3
21	R:R:K166	6.1525	4	2	3
22	R:R:F167	10.36	4	2	1
23	R:R:Q182	7.39	4	0	6
24	R:R:F220	8.0425	4	5	5
25	R:R:Y240	5.62333	6	0	3
26	R:R:W241	18.4	4	0	4
27	R:R:F242	6.915	4	0	5
28	R:R:W246	13.8225	4	0	4
29	R:R:R262	7.014	5	0	4
30	R:R:Y276	5.6925	4	0	9
31	R:R:F277	5.01	4	0	7
32	R:R:R283	7.5425	4	1	6
33	L:L:?1	11.4333	6	2	0

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:M79	R:R:R262	21.2044	4.96	No	Yes	0	5	4
2	R:R:F75	R:R:M79	21.1771	3.73	Yes	No	3	6	5
3	R:R:H57	R:R:I63	17.3209	3.98	Yes	No	0	6	7
4	R:R:I63	R:R:S142	18.1414	7.74	No	No	0	7	9
5	R:R:S142	R:R:Y64	18.8725	13.99	No	Yes	0	9	8
6	R:R:I119	R:R:Y64	98.2041	3.63	No	Yes	0	9	8
7	R:R:I119	R:R:Y276	98.5961	7.25	No	Yes	0	9	9
8	R:R:L116	R:R:Y276	100	4.69	No	Yes	0	9	9
9	R:R:L116	R:R:L68	49.494	5.54	No	No	0	9	9
10	R:R:D72	R:R:L68	49.5743	9.5	Yes	No	0	9	9
11	R:R:D72	R:R:S269	99.9562	8.83	Yes	No	0	9	9
12	R:R:F75	R:R:S269	94.419	7.93	Yes	No	3	6	9
13	R:R:L116	R:R:N272	50.9381	6.87	No	No	0	9	9
14	R:R:D72	R:R:N272	51.2188	6.73	Yes	No	0	9	9
15	R:R:Q122	R:R:Y64	79.8056	11.27	No	Yes	0	9	8
16	R:R:F61	R:R:Q122	38.7423	14.05	Yes	No	1	8	9
17	R:R:F133	R:R:Q122	40.5802	4.68	Yes	No	1	7	9
18	R:R:F61	R:R:S126	33.774	5.28	Yes	No	1	8	8
19	R:R:F133	R:R:S126	32.4375	7.93	Yes	No	1	7	8
20	R:R:F107	R:R:W150	14.0992	5.01	No	Yes	0	5	9
21	R:R:F107	R:R:N157	16.8815	12.08	No	No	0	5	7
22	R:R:N157	R:R:Q182	19.5033	3.96	No	Yes	0	7	6
23	R:R:F242	R:R:Q182	35.5662	11.71	Yes	Yes	0	5	6
24	R:R:F242	R:R:W241	22.2419	8.02	Yes	Yes	0	5	4
25	R:R:W241	R:R:Y106	39.8235	40.51	Yes	Yes	0	4	3
26	R:R:K102	R:R:Y106	13.328	3.58	No	Yes	0	3	3
27	R:R:W241	R:R:Y240	11.7053	3.86	Yes	Yes	0	4	3
28	R:R:F258	R:R:Y240	10.3178	14.44	No	Yes	0	3	3
29	R:R:F258	R:R:R262	10.7991	16.03	No	Yes	0	3	4
30	R:R:F75	R:R:Y109	21.2555	7.22	Yes	Yes	3	6	8
31	R:R:S238	R:R:Y109	19.5362	5.09	No	Yes	0	7	8
32	R:R:S126	R:R:V127	64.8531	3.23	No	No	0	8	8
33	R:R:L201	R:R:V127	63.4802	4.47	No	No	0	8	8
34	R:R:L201	R:R:V223	62.2896	2.98	No	No	0	8	8
35	R:R:S198	R:R:V223	41.4444	4.85	No	No	0	8	8
36	R:R:S198	R:R:V227	40.0168	3.23	No	No	0	8	8
37	R:R:L231	R:R:V227	37.1451	2.98	No	No	0	8	8
38	R:R:F230	R:R:L231	32.8076	3.65	No	No	0	9	8
39	R:R:F230	R:R:M194	22.5591	16.17	No	No	0	9	8
40	R:R:M194	R:R:T117	19.5982	4.52	No	No	0	8	8
41	R:R:T117	R:R:V193	15.1294	3.17	No	No	0	8	6
42	R:R:S197	R:R:V193	13.6325	1.62	No	No	0	8	6
43	R:R:T160	R:R:V178	11.3315	4.76	No	No	0	4	4
44	R:R:Q182	R:R:T160	12.606	7.09	Yes	No	0	6	4
45	R:R:I186	R:R:S238	18.9801	6.19	No	No	0	7	7
46	R:R:F242	R:R:I186	18.0447	3.77	Yes	No	0	5	7
47	R:R:F202	R:R:V223	21.075	3.93	No	No	0	5	8
48	R:R:F202	R:R:F220	18.1067	17.15	No	Yes	0	5	5
49	R:R:M105	R:R:Y106	51.5361	11.97	Yes	Yes	0	4	3
50	L:L:?1	R:R:W241	16.0392	21.21	Yes	Yes	0	0	4
51	R:R:F75	R:R:M105	53.7659	4.98	Yes	Yes	3	6	4

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:E99	R:R:R103	11.63	2	Yes	Yes	5	4	2	1
R:R:E99	R:R:S165	8.62	2	Yes	Yes	5	3	2	2
R:R:K102	R:R:R103	4.95	0	No	Yes	3	4	2	1
R:R:K102	R:R:Y106	3.58	0	No	Yes	3	3	2	2
R:R:R103	R:R:S161	9.22	2	Yes	No	4	3	1	2
R:R:R103	R:R:S165	6.59	2	Yes	Yes	4	3	1	2
L:L:?1	R:R:R103	5.66	2	Yes	Yes	0	4	0	1
R:R:W241	R:R:Y106	40.51	0	Yes	Yes	4	3	1	2
R:R:S161	R:R:S165	4.89	2	No	Yes	3	3	2	2
R:R:C164	R:R:C175	7.28	2	No	No	6	8	1	1
L:L:?1	R:R:C164	9.24	2	Yes	No	0	6	0	1
R:R:C175	R:R:W246	5.22	2	No	Yes	8	4	1	2
L:L:?1	R:R:C175	3.69	2	Yes	No	0	8	0	1
R:R:D179	R:R:W246	14.52	0	No	Yes	3	4	1	2
L:L:?1	R:R:D179	11.06	2	Yes	No	0	3	0	1
R:R:W241	R:R:Y240	3.86	0	Yes	Yes	4	3	1	2
R:R:F242	R:R:W241	8.02	0	Yes	Yes	5	4	2	1
L:L:?1	R:R:W241	21.21	2	Yes	Yes	0	4	0	1
R:R:W246	R:R:Y245	13.5	0	Yes	No	4	4	2	1
L:L:?1	R:R:Y245	17.74	2	Yes	No	0	4	0	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

Similarity	Network Type	Name	Ligand	Description
85.71	Single	7Y12	Beta-alanine	7Y12-MRGPRD-Beta-alanine-Gi1/&β;1/&γ;2
33.33	Single	7VDM	Substance P	7VDM-MRGPRX2-Substance P-Gi1/&β;1/&γ;2
23.08	Single	8HJ5	PubChem 139030531	8HJ5-MRGPRX1-PubChem 139030531-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
20.00	Single	7VV0	PAMP-12	7VV0-MRGPRX2-PAMP-12
20.00	Single	8DWG	Proenkephalin-A	8DWG-MRGPRX1-Proenkephalin-A-ML382-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
18.18	Single	7S8O	(R)-Zinc-3573	7S8O-MRGPRX2-(R)-Zinc-3573-Gi1/&β;1/&γ;2
18.18	Single	8JGB	Conorfamide-Tx2	8JGB-MRGPRX1-Conorfamide-Tx2-Gi1/&β;1/&γ;2
17.65	Single	8DWC	Proenkephalin-A	8DWC-MRGPRX1-Proenkephalin-A-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
17.65	Single	8JGF	BAM8-22	8JGF-MRGPRX1-BAM8-22-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
16.67	Single	7S8N	(R)-Zinc-3573	7S8N-MRGPRX2-(R)-Zinc-3573-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
16.67	Single	7VDH	C48/80	7VDH-MRGPRX2-C48/80-Gi1/&β;1/&γ;2
15.38	Single	7VDL	Cortistatin-14	7VDL-MRGPRX2-Cortistatin-14-Gi1/&β;1/&γ;2
15.38	Single	7VV5	C48/80	7VV5-MRGPRX2-C48/80-Gi1/&β;1/&γ;2
15.38	Single	8DWH	Compound-16	8DWH-MRGPRX1-Compound-16-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
15.00	Single	8IZB	Lysophosphatidylserine	8IZB-GPR174-Lysophosphatidylserine-Gs/&β;1/&γ;2
14.29	Single	7UTZ	PubChem 644078	7UTZ-TSH-TR1402-PubChem 644078-Gs/&β;1/&γ;2
14.29	Single	7VV6	C48/80	7VV6-MRGPRX2-C48/80
14.29	Single	8K4N	VF0	8K4N-GPR34-VF0-Gi1/&β;1/&γ;2
14.29	Single	8T3V	DHA	8T3V-FFA1-DHA-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
13.33	Single	7E9G	JNJ-40411813	7E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/&β;1/&γ;2
13.33	Single	7PP1	Selatogrel	7PP1-P2Y₁₂-Selatogrel
13.33	Single	8JGG	BAM8-22	8JGG-MRGPRX1-BAM8-22-Gi1/&β;1/&γ;2
13.33	Consensus	fsh_on_allo	Other Ligand	8I2G-FSH-Glycoprotein hormones alpha chain-Compound 716340-Gs/&β;1/&γ;2
13.04	Consensus	ste2_on	Orthosteric Ligand	7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
12.50	Single	4NTJ	AZD1283	4NTJ-P2Y₁₂-AZD1283
12.50	Single	5ZBQ	UR-MK-299	5ZBQ-Y₁-UR-MK-299
12.50	Single	6RZ4	Pranlukast	6RZ4-CysLT₁-Pranlukast-Na
12.50	Single	8ID9	Eicosapentaenoic acid	8ID9-FFA4 (GPR120)-Eicosapentaenoic acid-Gi1/&β;1/&γ;2
12.50	Single	8IZ4	Lysophosphatidylserine	8IZ4-GPR34-Lysophosphatidylserine-Gi1/&β;1/&γ;2
12.50	Single	8KH5	Lysophosphatidylserine	8KH5-GPR174-Lysophosphatidylserine-Gs/&β;1/&γ;2
12.00	Single	7XV3	Lysophosphatidylserine	7XV3-GPR174-Lysophosphatidylserine-chim(NtGi1-Gs)/&β;1/&γ;2
11.76	Single	5ZBH	BMS-193885	5ZBH-Y₁-BMS-193885
11.76	Single	6KO5	PubChem 57400002	6KO5-Ghrelin-PubChem 57400002
11.76	Single	7F58	THIQ	7F58-MC₄-THIQ-Gs/&β;1/&γ;2
11.76	Single	7R0C	Acyclovir triphosphate	7R0C-V₂-Acyclovir triphosphate-Arrestin2
11.76	Single	7S8M	Cortistatin-14	7S8M-MRGPRX2-Cortistatin-14-Gi1/&β;1/&γ;2
11.76	Single	7W41	PD176252	7W41-BB₂-PD176252
11.76	Single	8I2G	Compound 716340	8I2G-FSH-Glycoprotein hormones alpha chain-Compound 716340-Gs/&β;1/&γ;2
11.76	Single	8XBI	S3E-LysoPS	8XBI-GPR34-S3E-LysoPS
11.76	Consensus	bb2_off	Orthosteric Ligand	7W41-BB₂-PD176252
11.76	Consensus	bombesin_off	Orthosteric Ligand	bb2_off
11.76	Consensus	gs_ffa	Orthosteric Ligand	8EIT-FFA1 (GPR40)-Doconexent-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2 8EJC-FFA1 (GPR40)-TAK-875-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2 8H4K-FFA4-GW9508-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8T3V-FFA1-DHA-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8T3S-FFA2-Butyric acid-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8T3Q-FFA4-DHA-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8GD9-EP₄-Rivenprost-Gs/&β;1/&γ;2 8GDA-EP₄-L902688-Gs/&β;1/&γ;2 8GDB-EP₄-PGE2-Gs/&β;1/&γ;2
11.76	Consensus	npy1_off	Orthosteric Ligand	5ZBH-Y₁-BMS-193885 5ZBQ-Y₁-UR-MK-299
11.76	Consensus	npy_off	Orthosteric Ligand	npy2_off npy1_off
11.11	Single	3VW7	Vorapaxar; Na	3VW7-PAR1-Vorapaxar; Na
11.11	Single	5MZP	Caffeine	5MZP-A_2A-Caffeine-Na
11.11	Single	6HLP	Netupitant	6HLP-NK₁-Netupitant
11.11	Single	6RZ7	ONO-2570366	6RZ7-CysLT₂-ONO-2570366
11.11	Single	7EXD	Lasmiditan	7EXD-5-HT_1F-Lasmiditan-Gi1/&β;1/&γ;2
11.11	Single	7F55	Bremelanotide	7F55-MC₄-Bremelanotide-Gs/&β;1/&γ;2
11.11	Single	7XW5	ML109	7XW5-TSH-TSH-ML109-Gs/&β;1/&γ;2
11.11	Single	7XW6	ML109	7XW6-TSH-M22 Fab-ML109-Gs/&β;1/&γ;2
11.11	Single	7XW9	TRH	7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
11.11	Single	7XXI	2MeSADP	7XXI-P2Y₁₂-2MeSADP-Gi2/&β;1/&γ;2
11.11	Single	7Y24	Octreotide	7Y24-SST2-Octreotide-Go/&β;1/&γ;2
11.11	Single	8WRB	Lysophosphatidylserine	8WRB-GPR34-Lysophosphatidylserine-Gi1/&β;1/&γ;2
11.11	Consensus	5ht1f_on	Orthosteric Ligand	7EXD-5-HT_1F-Lasmiditan-Gi1/&β;1/&γ;2
11.11	Consensus	gs_trh	Orthosteric Ligand	7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
11.11	Consensus	trh_on	Orthosteric Ligand	7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
11.11	Consensus	tsh_on_allo	Other Ligand	7XW5-TSH-TSH-ML109-Gs/&β;1/&γ;2
10.53	Single	4PXZ	2MeSADP	4PXZ-P2Y₁₂-2MeSADP
10.53	Single	5TUD	Ergotamine	5TUD-5-HT_2B-Ergotamine
10.53	Single	6RZ9	ONO-2770372	6RZ9-CysLT₂-ONO-2770372
10.53	Single	8JD3	HZR; PEF	8JD3-mGlu2; mGlu3-Glutamate-HZR; PEF-Gi1/&β;1/&γ;2
10.53	Consensus	cyslt2_off	Orthosteric Ligand	6RZ6-CysLT₂-ONO-2570366 6RZ9-CysLT₂-ONO-2770372 6RZ8-CysLT₂-ONO-2080365
10.53	Consensus	cyslt_off	Orthosteric Ligand	cyslt2_off
10.00	Single	5MZJ	Theophylline	5MZJ-A_2A-Theophylline-Na
10.00	Single	6RZ6	ONO-2570366	6RZ6-CysLT₂-ONO-2570366
10.00	Single	7F9Z	GHRP-6	7F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
10.00	Single	7S8L	Cortistatin-14	7S8L-MRGPRX2-Cortistatin-14-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
10.00	Single	8H4I	Doconexent	8H4I-FFA4-Doconexent-chim(NtGi1-Gs)/&β;1/&γ;2
10.00	Single	8PWN	Theophylline	8PWN-A_2A-Theophylline
10.00	Single	8SAI	1-oleoyl-2-hydroxy-sn-glycero-3-phospho-L-serine	8SAI-GPR34-1-oleoyl-2-hydroxy-sn-glycero-3-phospho-L-serine-Gi1/&β;1/&γ;2
10.00	Consensus	class-c_on	Other Ligand	gabab_on mglu_on
10.00	Consensus	mc4_on	Orthosteric Ligand	7F53-MC₄-Alpha-MSH-Gs/&β;1/&γ;2 7F55-MC₄-Bremelanotide-Gs/&β;1/&γ;2 7PIV-MC₄-Setmelanotide-Gs/&β;1/&γ;2 7F58-MC₄-THIQ-Gs/&β;1/&γ;2 7F54-MC₄-Afamelanotide-Gs/&β;1/&γ;2
9.52	Single	6RZ8	ONO-2080365	6RZ8-CysLT₂-ONO-2080365
9.52	Single	7F54	Afamelanotide	7F54-MC₄-Afamelanotide-Gs/&β;1/&γ;2
9.52	Single	8G59	TUG-891	8G59-FFA4 (GPR120)-TUG-891-Gi1/&β;1/&γ;2
9.52	Single	8XBH	S3E-LysoPS	8XBH-GPR34-S3E-LysoPS-Gi1/&β;1/&γ;2
9.52	Consensus	sst2_on	Orthosteric Ligand	7XMR-SST2-Somatostatin-14-Gi1/&β;1/&γ;2 7XAU-SST2-Octreotide-Gi1/&β;1/&γ;2 7YAC-SST2-Paltusotine-Gi1/&β;1/&γ;2
9.09	Single	3RFM	Caffeine	3RFM-A_2A-Caffeine
9.09	Single	6OT0	25(S)-Epoxycholesterol	6OT0-SMO-25(S)-Epoxycholesterol-Gi1/&β;1/&γ;2
9.09	Single	6OY9	All-trans-retinal	6OY9-Rhodopsin-All-trans-retinal-Gt/&β;1/&γ;1
9.09	Single	7DD5	Ca; Ca; Tryptophan; NPS-2143	7DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
9.09	Single	7PIU	Setmelanotide	7PIU-MC₄-Setmelanotide-Gs/&β;1/&γ;2
9.09	Single	7PIV	Setmelanotide	7PIV-MC₄-Setmelanotide-Gs/&β;1/&γ;2
9.09	Single	7XMS	Somatostatin-14	7XMS-SST4-Somatostatin-14-Gi1/&β;1/&γ;2
9.09	Single	8A2O	Theophylline	8A2O-A_2A-Theophylline-Na
9.09	Single	8IOC	Gamma-MSH	8IOC-MC₃-Gamma-MSH-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
8.70	Single	6W25	SHU9119	6W25-MC₄-SHU9119-Ca
8.70	Single	7XAU	Octreotide	7XAU-SST2-Octreotide-Gi1/&β;1/&γ;2
8.70	Single	7XOU	Cholecystokinin-8	7XOU-CCK_A-Cholecystokinin-8-Gs/&β;1/&γ;2
8.70	Consensus	mc3_on	Orthosteric Ligand	8IOC-MC₃-Gamma-MSH-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
8.33	Single	3UZA	GTPL9236	3UZA-A_2A-GTPL9236
8.33	Single	6FK9	PubChem 132473036	6FK9-Rhodopsin-PubChem 132473036
8.33	Single	7RYC	Oxytocin	7RYC-OT-Oxytocin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
8.33	Single	7V6A	PubChem 9864275	7V6A-M₄-PubChem 9864275-Gi1/&β;1/&γ;2
8.33	Single	7WC5	Psilocin	7WC5-5-HT_2A-Psilocin
8.33	Single	8F76	-	8F76-OR51E2-Gs/&β;1/&γ;2
8.33	Single	8J21	Butyric acid	8J21-FFA3-Butyric acid-Gi1/&β;1/&γ;2
8.33	Single	8J24	Acetic acid	8J24-FFA2-Acetic acid-Gi1/&β;1/&γ;2
8.33	Single	8XZJ	WN353	8XZJ-Apelin-WN353-Gi1/&β;1/&γ;2
8.33	Consensus	ffa3_on	Orthosteric Ligand	8J21-FFA3-Butyric acid-Gi1/&β;1/&γ;2
8.33	Consensus	ghrelin_on	Orthosteric Ligand	7W2Z-Ghrelin-Ghrelin-Go/&β;1/&γ;2 7F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7NA8-Ghrelin-PubChem 178024-Gi1/&β;1/&γ;2
8.33	Consensus	gi_somatostatin	Orthosteric Ligand	7XMR-SST2-Somatostatin-14-Gi1/&β;1/&γ;2 7XMT-SST4-J-2156-Gi1/&β;1/&γ;2 7XAU-SST2-Octreotide-Gi1/&β;1/&γ;2 7YAC-SST2-Paltusotine-Gi1/&β;1/&γ;2
8.33	Consensus	gip_on_allo	Other Ligand	7RBT-GIP-Tirzepatide-PubChem 163183774-chim(NtGi1-Gs)/&β;1/&γ;2
8.00	Single	7KH0	Acyclovir triphosphate	7KH0-V₂-Acyclovir triphosphate-chim(NtGi1-Gs)/&β;1/&γ;2
8.00	Single	7X9B	Neuropeptide Y	7X9B-Y₂-Neuropeptide Y-Gi1/&β;1/&γ;2
8.00	Single	7X9C	Pancreatic Hormone	7X9C-Y₄-Pancreatic Hormone-Gi1/&β;1/&γ;2
8.00	Single	8HCQ	Endothelin-1	8HCQ-ET_A-Endothelin-1-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
8.00	Single	8IOD	PG-901	8IOD-MC₅-PG-901-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
8.00	Consensus	eta_on	Orthosteric Ligand	8HCQ-ET_A-Endothelin-1-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
8.00	Consensus	gs_ghrelin	Orthosteric Ligand	7F9Y-Ghrelin-Ghrelin-28-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
8.00	Consensus	gs_melanocortin	Orthosteric Ligand	7F4D-MC₁-Alpha-MSH-chim(NtGi1-Gs)/&β;1/&γ;2 7F4H-MC₁-Afamelanotide-chim(NtGi1-Gs)/&β;1/&γ;2 7F54-MC₄-Afamelanotide-Gs/&β;1/&γ;2 7F53-MC₄-Alpha-MSH-Gs/&β;1/&γ;2 7F55-MC₄-Bremelanotide-Gs/&β;1/&γ;2 7PIV-MC₄-Setmelanotide-Gs/&β;1/&γ;2 7F4I-MC₁-SHU9119-chim(NtGi1-Gs)/&β;1/&γ;2 7F58-MC₄-THIQ-Gs/&β;1/&γ;2
7.69	Single	3PBL	Eticlopride	3PBL-D₃-Eticlopride
7.69	Single	5OLV	LUAA41063	5OLV-A_2A-LUAA41063-Na
7.69	Single	6FK6	PubChem 132473033	6FK6-Rhodopsin-PubChem 132473033
7.69	Single	6HLL	CP99994	6HLL-NK₁-CP99994
7.69	Single	6PGS	Geraniol	6PGS-Rhodopsin-Geraniol-Gt(CT)
7.69	Single	6PH7	Nerol	6PH7-Rhodopsin-Nerol-Gt(CT)
7.69	Single	6QNO	All-trans-retinal	6QNO-Rhodopsin-All-trans-retinal-Gi1/&β;1/&γ;1
7.69	Single	6TP4	ACT-462206	6TP4-OX₁-ACT-462206
7.69	Single	6TQ4	PubChem 16046844	6TQ4-OX₁-PubChem 16046844-Na
7.69	Single	7DD5	Ca; Ca; Tryptophan; NPS-2143	7DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
7.69	Single	7DD7	Ca; Ca; Tryptophan; Evocalcet	7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
7.69	Single	7E2Y	Serotonin	7E2Y-5-HT_1A-Serotonin-Gi1/&β;1/&γ;2
7.69	Single	7SRQ	LSD	7SRQ-5-HT_2B-LSD
7.69	Single	7VUI	JNJ-63533054	7VUI-GPR139-JNJ-63533054-GTP-chim(Gs-CtGq)/&β;1/&γ;2
7.69	Single	7XT9	Serotonin	7XT9-5-HT₄-Serotonin-Gs/&β;1/&γ;2
7.69	Single	7XTA	Serotonin	7XTA-5-HT₄-Serotonin-Gi1/&β;1/&γ;2
7.69	Single	7XTB	Serotonin	7XTB-5-HT₆-Serotonin-Gs/&β;1/&γ;2
7.69	Single	7YS6	Serotonin	7YS6-5-HT₆-Serotonin-chim(NtGi1-Gs)/&β;1/&γ;2
7.69	Single	8A2P	LUAA47070	8A2P-A_2A-LUAA47070-Na
7.69	Single	8EF6	Morphine	8EF6-μ-Morphine-Gi1/&β;1/&γ;2
7.69	Single	8GH1	Epinephrine	8GH1-β₂-Epinephrine
7.69	Single	8H8J	Lodoxamide	8H8J-GPR35-Lodoxamide-Ca-chim(NtGi1L-G13)/&β;1/&γ;2
7.69	Single	8J6Q	Compound 9n	8J6Q-HCA₂-Beta-hydroxybutyrate-Compound 9n-Gi1/&β;1/&γ;2
7.69	Single	8JII	Compound 9n	8JII-HCA₂-Niacin-Compound 9n-Gi1/&β;1/&γ;2
7.69	Single	8SZF	Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW	8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
7.69	Consensus	5ht4_on	Orthosteric Ligand	7XT8-5-HT₄-Serotonin-Gs/&β;1/&γ;2
7.69	Consensus	d3_off	Orthosteric Ligand	3PBL-D₃-Eticlopride
7.69	Consensus	gs_vasopressin-ot	Orthosteric Ligand	7RYC-OT-Oxytocin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 7DW9-V₂-Acyclovir triphosphate-chim(NtGi1-Gs)/&β;1/&γ;2
7.69	Consensus	hca2_on_allo	Other Ligand	8J6P-HCA₂-Niacin-Compound 9n-Gi1/&β;1/&γ;2 8J6Q-HCA₂-Beta-hydroxybutyrate-Compound 9n-Gi1/&β;1/&γ;2
7.69	Consensus	npy2_on	Orthosteric Ligand	7YOO-Y₂-Neuropeptide Y-Gi1/&β;1/&γ;2 7YON-Y₂-Peptide YY(3-36)-Gi1/&β;1/&γ;2
7.69	Consensus	npy4_on	Orthosteric Ligand	7X9C-Y₄-Pancreatic Hormone-Gi1/&β;1/&γ;2
7.69	Consensus	ox1_off_allo	Orthosteric Ligand	6TOD-OX₁-EMPA-Na 6TOS-OX₁-GSK1059865-Na 6TQ4-OX₁-PubChem 16046844-Na 6TO7-OX₁-Suvorexant-Na
7.41	Single	7F53	Alpha-MSH	7F53-MC₄-Alpha-MSH-Gs/&β;1/&γ;2
7.41	Single	7YOO	Neuropeptide Y	7YOO-Y₂-Neuropeptide Y-Gi1/&β;1/&γ;2
7.41	Consensus	ste2_on	Orthosteric Ligand	7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
7.14	Single	2X72	All-trans-retinal	2X72-Rhodopsin-All-trans-retinal-Gt(CT)
7.14	Single	3PWH	ZM241385	3PWH-A_2A-ZM241385
7.14	Single	3VG9	ZM241385	3VG9-A_2A-ZM241385-Antibody
7.14	Single	3VGA	ZM241385	3VGA-A_2A-ZM241385-Antibody
7.14	Single	4S0V	Suvorexant	4S0V-OX₂-Suvorexant
7.14	Single	5DHH	SB-612111	5DHH-NOP-SB-612111
7.14	Single	5K2D	ZM241385	5K2D-A_2A-ZM241385
7.14	Single	5OLH	Vipadenant	5OLH-A_2A-Vipadenant-Na
7.14	Single	5OLO	Tozadenant	5OLO-A_2A-Tozadenant-Na
7.14	Single	5WS3	EMPA	5WS3-OX₂-EMPA
7.14	Single	6AKX	A4R	6AKX-CCR5-A4R
7.14	Single	6B73	PubChem 131955138	6B73-κ-PubChem 131955138
7.14	Single	6D9H	Adenosine	6D9H-A₁-Adenosine-Gi2/&β;1/&γ;2
7.14	Single	6FKB	PubChem 132473038	6FKB-Rhodopsin-PubChem 132473038
7.14	Single	6JZH	ZM241385	6JZH-A_2A-ZM241385-Na
7.14	Single	6NWE	Octyl Beta-D-Glucopyranoside	6NWE-Rhodopsin-Octyl Beta-D-Glucopyranoside-Gt(CT)
7.14	Single	6PS7	ZM241385	6PS7-A_2A-ZM241385-Na
7.14	Single	6TOD	EMPA	6TOD-OX₁-EMPA-Na
7.14	Single	6TPJ	Suvorexant	6TPJ-OX₂-Suvorexant
7.14	Single	6TQ6	PubChem 145714283	6TQ6-OX₁-PubChem 145714283
7.14	Single	7BR3	Elagolix	7BR3-GnRH₁-Elagolix
7.14	Single	7DD7	Ca; Ca; Tryptophan; Evocalcet	7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
7.14	Single	7DHR	Isoprenaline	7DHR-β₂-Isoprenaline-Gs/&β;1/&γ;2
7.14	Single	7EJ0	L-Norepinephrine	7EJ0-α_2a-L-Norepinephrine-Go/&β;1/&γ;2
7.14	Single	7F1O	Dopamine	7F1O-D₁-Dopamine-GDP; Mg-Gs/&β;1/&γ;2
7.14	Single	7F24	Dopamine	7F24-D₁-Dopamine-GDP-Gs/&β;1/&γ;2
7.14	Single	7F8U	Lintitript	7F8U-CCK_A-Lintitript
7.14	Single	7F8Y	Devazepide	7F8Y-CCK_A-Devazepide
7.14	Single	7LD4	Adenosine	7LD4-A₁-Adenosine-Gi2/&β;1/&γ;2
7.14	Single	7LJD	Dopamine	7LJD-D₁-Dopamine-Mevidalen-Gs/&β;1/&γ;1
7.14	Single	7M3E	Ca; Ca; Tryptophan; NPS-2143; PO4	7M3E-CaS-Ca; Ca; Tryptophan; NPS-2143; PO4
7.14	Single	7M3E	Ca; Ca; Tryptophan; NPS-2143; PO4	7M3E-CaS-Ca; Ca; Tryptophan; NPS-2143; PO4
7.14	Single	7M3F	Ca; Ca; Tryptophan; Cinacalcet; PO4	7M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
7.14	Single	7SIL	Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4	7SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
7.14	Single	7SIL	Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4	7SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
7.14	Single	7SRR	LSD	7SRR-5-HT_2B-LSD-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
7.14	Single	7SRS	LSD	7SRS-5-HT_2B-LSD-Arrestin2
7.14	Single	7VGX	Neuropeptide Y	7VGX-Y₁-Neuropeptide Y-Gi1/&β;1/&γ;2
7.14	Single	7VUJ	JNJ-63533054	7VUJ-GPR139-JNJ-63533054-GDP-chim(Gs-CtGq)/&β;1/&γ;2
7.14	Single	7W0M	PubChem 122701908	7W0M-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
7.14	Single	7WV9	ZCZ011	7WV9-CB₁-PubMed 104895-ZCZ011-Gi2/&β;1/&γ;2
7.14	Single	7X2F	Dopamine	7X2F-D₁-Dopamine-Mevidalen-Gs/&β;1/&γ;2
7.14	Single	7X5H	5-CT	7X5H-5-HT_5A-5-CT-Gi1/&β;1/&γ;2
7.14	Single	7XRR	Lemborexant	7XRR-OX₂-Lemborexant
7.14	Single	7XT8	Serotonin	7XT8-5-HT₄-Serotonin-Gs/&β;1/&γ;2
7.14	Single	8DU3	PubChem 105526064	8DU3-A_2A-PubChem 105526064
7.14	Single	8EFO	PZM21	8EFO-μ-PZM21-Gi1/&β;1/&γ;2
7.14	Single	8FN0	Neurotensin/neuromedin N	8FN0-NTS₁-Neurotensin/neuromedin N-PubChem 118610427-chim(NtGi1-Go)/&β;1/&γ;2
7.14	Single	8GED	Epinephrine	8GED-β₂-Epinephrine-Gs/&β;1/&γ;2
7.14	Single	8GG9	Epinephrine	8GG9-β₂-Epinephrine-GTP-Gs/&β;1/&γ;2
7.14	Single	8GGF	Epinephrine	8GGF-β₂-Epinephrine-GTP-Gs/&β;1/&γ;2
7.14	Single	8GNG	Istradefylline	8GNG-A_2A-Istradefylline
7.14	Single	8HDP	Adenosine	8HDP-A_2B-Adenosine-Gs/&β;1/&γ;2
7.14	Single	8J20	Valeric acid	8J20-FFA3-Valeric acid-AR420626-Gi1/&β;1/&γ;2
7.14	Single	8J6P	Compound 9n	8J6P-HCA₂-Niacin-Compound 9n-Gi1/&β;1/&γ;2
7.14	Single	8JHY	Compound 9n	8JHY-HCA₂-Compound 9n-Gi1/&β;1/&γ;2
7.14	Single	8SZF	Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW	8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
7.14	Single	8SZG	Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW	8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-chim(NtGi1-Gq)/&β;1/&γ;2
7.14	Single	8T3S	Butyric acid	8T3S-FFA2-Butyric acid-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
7.14	Single	8UNL	Epinephrine	8UNL-β₂-Epinephrine-GTP-Gs/&β;1/&γ;2
7.14	Single	8UNT	Epinephrine	8UNT-β₂-Epinephrine-GTP-Gs/&β;1/&γ;2
7.14	Single	8UNU	Epinephrine	8UNU-β₂-Epinephrine-GTP-Gs/&β;1/&γ;2
7.14	Single	8UNW	Epinephrine	8UNW-β₂-Epinephrine-GTP-Gs/&β;1/&γ;2
7.14	Single	8UO0	Epinephrine	8UO0-β₂-Epinephrine-GTP-Gs/&β;1/&γ;2
7.14	Single	8WPG	Tryptophan; Cinacalcet; PO4; Ca	8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
7.14	Consensus	5ht_on	Orthosteric Ligand	5ht1_on 5ht2_on 5ht4_on 5ht5_on 5ht6_on 5ht7_on
7.14	Consensus	a1_on	Orthosteric Ligand	7LD4-A₁-Adenosine-Gi2/&β;1/&γ;2
7.14	Consensus	a2a_off_allo	Orthosteric Ligand	6ZDR-A_2A-HMS1413f12-Na 6GT3-A_2A-Imaradenant-Na 8CU7-A_2A-LJ-4517-Na 5OLV-A_2A-LUAA41063-Na 5N2R-A_2A-PubChem 92460631; psb36-Na 5MZJ-A_2A-Theophylline-Na 5OLO-A_2A-Tozadenant-Na 5OLH-A_2A-Vipadenant-Na 5NM4-A_2A-ZM241385-Na 8GNE-A_2A-KW-6356-Na 8JWZ-A_2A-AB928-Na 5MZP-A_2A-Caffeine-Na 8CIC-A_2A-Etrumadenant-Na
7.14	Consensus	alpha2_off	Orthosteric Ligand	alpha2a_off alpha2c_off
7.14	Consensus	cb1_on_allo	Other Ligand	7WV9-CB₁-PubMed 104895-ZCZ011-Gi2/&β;1/&γ;2
7.14	Consensus	ffa3_on_allo	Orthosteric Ligand	8J20-FFA3-Valeric acid-AR420626-Gi1/&β;1/&γ;2
7.14	Consensus	gi_nucleotide	Orthosteric Ligand	7LD4-A₁-Adenosine-Gi2/&β;1/&γ;2
7.14	Consensus	gnrh1_off	Orthosteric Ligand	7BR3-GnRH₁-Elagolix
7.14	Consensus	gs_5ht	Orthosteric Ligand	7XT8-5-HT₄-Serotonin-Gs/&β;1/&γ;2 7XTB-5-HT₆-Serotonin-Gs/&β;1/&γ;2 8JLZ-5-HT₆-ST1936-Gs/&β;1/&γ;2 7XTC-5-HT₇-5-CT-Gs/&β;1/&γ;2 6WHA-5-HT_2A-DB13948-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 7RAN-5-HT_2A-PubChem 164575847-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8DPF-5-HT_2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8DPG-5-HT_2C-Psilocin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
7.14	Consensus	mglu_on	Other Ligand	mglu2_on mglu4_on
7.14	Consensus	orexin_off	Orthosteric Ligand	ox2_off ox1_off
7.14	Consensus	p2y_off	Orthosteric Ligand	p2y1_off p2y12_off
6.67	Single	2YDO	Adenosine	2YDO-A_2A-Adenosine
6.67	Single	3REY	PubChem 5697	3REY-A_2A-PubChem 5697
6.67	Single	3RZE	Cidoxepin	3RZE-H₁-Cidoxepin
6.67	Single	3UZC	PubChem 135566609	3UZC-A_2A-PubChem 135566609
6.67	Single	4DKL	Beta-funaltrexamine	4DKL-μ-Beta-funaltrexamine
6.67	Single	4LDO	L-Epinephrine	4LDO-β₂-L-Epinephrine
6.67	Single	4MBS	Maraviroc	4MBS-CCR5-Maraviroc
6.67	Single	4N6H	Naltrindole	4N6H-δ-Naltrindole-Na
6.67	Single	4ZJC	SB-674042	4ZJC-OX₁-SB-674042
6.67	Single	5IU4	ZM241385	5IU4-A_2A-ZM241385-Na
6.67	Single	5IU7	Q27456346	5IU7-A_2A-Q27456346-Na
6.67	Single	5IUB	Q27456344	5IUB-A_2A-Q27456344-Na
6.67	Single	5JTB	ZM241385	5JTB-A_2A-ZM241385
6.67	Single	5K2B	ZM241385	5K2B-A_2A-ZM241385-Na
6.67	Single	5K2C	ZM241385	5K2C-A_2A-ZM241385-Na
6.67	Single	5NLX	ZM241385	5NLX-A_2A-ZM241385-Na
6.67	Single	5NM4	ZM241385	5NM4-A_2A-ZM241385-Na
6.67	Single	5TE3	Octyl Beta-D-Glucopyranoside	5TE3-Rhodopsin-Octyl Beta-D-Glucopyranoside
6.67	Single	5UVI	ZM241385	5UVI-A_2A-ZM241385
6.67	Single	6AQF	ZM241385	6AQF-A_2A-ZM241385
6.67	Single	6DS0	Ly266097	6DS0-5-HT_2B-Ly266097
6.67	Single	6FK8	PubChem 132473035	6FK8-Rhodopsin-PubChem 132473035
6.67	Single	6FKA	PubChem 132473037	6FKA-Rhodopsin-PubChem 132473037
6.67	Single	6IQL	L745870	6IQL-D₄-L745870
6.67	Single	6K41	Dexmedetomidine	6K41-α_2b-Dexmedetomidine-Go/&β;1/&γ;2
6.67	Single	6MH8	ZM241385	6MH8-A_2A-ZM241385
6.67	Single	6PEL	Citronellol	6PEL-Rhodopsin-Citronellol-Gt(CT)
6.67	Single	6PS4	ICI 118-551	6PS4-β₂-ICI 118-551
6.67	Single	6PS5	(S)-Propranolol	6PS5-β₂-(S)-Propranolol
6.67	Single	6TOS	GSK1059865	6TOS-OX₁-GSK1059865-Na
6.67	Single	6TP3	Nemorexant	6TP3-OX₁-Nemorexant
6.67	Single	6TPG	EMPA	6TPG-OX₂-EMPA
6.67	Single	6TPK	Retosiban	6TPK-OT-Retosiban
6.67	Single	6TPN	HTL6641	6TPN-OX₂-HTL6641
6.67	Single	6V9S	GTPL11403	6V9S-OX₁-GTPL11403
6.67	Single	6VI4	JDTic	6VI4-κ-JDTic
6.67	Single	6WJC	Muscarinic toxin 7	6WJC-M₁-Atropine-Muscarinic toxin 7
6.67	Single	6ZA8	RTI-3a	6ZA8-NTS₁-RTI-3a
6.67	Single	6ZDR	HMS1413f12	6ZDR-A_2A-HMS1413f12-Na
6.67	Single	6ZDV	PubChem 984073	6ZDV-A_2A-PubChem 984073-Na
6.67	Single	6ZIN	SR48692	6ZIN-NTS₁-SR48692
6.67	Single	7ARO	LUF5833	7ARO-A_2A-LUF5833-Na
6.67	Single	7BB6	Acyclovir triphosphate	7BB6-V₂-Acyclovir triphosphate-Gs/&β;1/&γ;2
6.67	Single	7CKW	Fenoldopam	7CKW-D₁-Fenoldopam-Gs/&β;1/&γ;2
6.67	Single	7CKZ	Dopamine	7CKZ-D₁-Dopamine-Mevidalen-Gs/&β;1/&γ;2
6.67	Single	7CMU	Pramipexole	7CMU-D₃-Pramipexole-Gi1/&β;1/&γ;2
6.67	Single	7CMV	PD128907	7CMV-D₃-PD128907-Gi1/&β;1/&γ;2
6.67	Single	7E33	BRL-54443	7E33-5-HT_1E-BRL-54443-Gi1/&β;1/&γ;2
6.67	Single	7EJ8	Brimonidine	7EJ8-α_2a-Brimonidine-Go/&β;1/&γ;2
6.67	Single	7EJA	Dexmedetomidine	7EJA-α_2a-Dexmedetomidine-Go/&β;1/&γ;2
6.67	Single	7F0T	Dopamine	7F0T-D₁-Dopamine-Gs/&β;1/&γ;2
6.67	Single	7F1Z	Dopamine	7F1Z-D₁-Dopamine-GDP-Gs/&β;1/&γ;2
6.67	Single	7JOZ	VFP	7JOZ-D₁-VFP-Gs/&β;1/&γ;2
6.67	Single	7RAN	PubChem 164575847	7RAN-5-HT_2A-PubChem 164575847-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
6.67	Single	7SR8	TAK-925	7SR8-OX₂-TAK-925-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
6.67	Single	7WC9	PubChem 162421364	7WC9-5-HT_2A-PubChem 162421364
6.67	Single	7XOV	SR146131	7XOV-CCK_A-SR146131-Gs/&β;1/&γ;2
6.67	Single	8DWG	ML382	8DWG-MRGPRX1-Proenkephalin-A-ML382-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
6.67	Single	8GEG	Epinephrine	8GEG-β₂-Epinephrine-Gs/&β;1/&γ;2
6.67	Single	8GG3	Epinephrine	8GG3-β₂-Epinephrine-GTP-Gs/&β;1/&γ;2
6.67	Single	8GG5	Epinephrine	8GG5-β₂-Epinephrine-GTP-Gs/&β;1/&γ;2
6.67	Single	8GGK	Epinephrine	8GGK-β₂-Epinephrine
6.67	Single	8GGL	Epinephrine	8GGL-β₂-Epinephrine
6.67	Single	8GGM	Epinephrine	8GGM-β₂-Epinephrine
6.67	Single	8GGP	Epinephrine	8GGP-β₂-Epinephrine
6.67	Single	8GGQ	Epinephrine	8GGQ-β₂-Epinephrine
6.67	Single	8H4L	Doconexent	8H4L-FFA4-Doconexent-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
6.67	Single	8IYX	YL-365	8IYX-GPR34-YL-365
6.67	Single	8THL	Epinephrine	8THL-Alpha1A-Epinephrine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
6.67	Single	8UNR	Epinephrine	8UNR-β₂-Epinephrine-GTP-Gs/&β;1/&γ;2
6.67	Single	8UNS	Epinephrine	8UNS-β₂-Epinephrine-GTP-Gs/&β;1/&γ;2
6.67	Single	8UNZ	Epinephrine	8UNZ-β₂-Epinephrine-GTP-Gs/&β;1/&γ;2
6.67	Single	8UO2	Epinephrine	8UO2-β₂-Epinephrine-GTP-Gs/&β;1/&γ;2
6.67	Single	8WC8	ZH8651	8WC8-TA1-ZH8651-chim(NtGi1-Gs)/&β;1/&γ;2
6.67	Single	8WPG	Tryptophan; Cinacalcet; PO4; Ca	8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
6.67	Single	9AXF	Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4	9AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
6.67	Consensus	5ht1e_on	Orthosteric Ligand	7E33-5-HT_1E-BRL-54443-Gi1/&β;1/&γ;2
6.67	Consensus	5ht5_on	Orthosteric Ligand	5ht5a_on
6.67	Consensus	5ht5a_on	Orthosteric Ligand	7UM5-5-HT_5A-5-CT-chim(NtGi1-Go)/&β;1/&γ;2 7UM6-5-HT_5A-Lisuride-chim(NtGi1-Go)/&β;1/&γ;2 7UM7-5-HT_5A-Methylergometrine-chim(NtGi1-Go)/&β;1/&γ;2
6.67	Consensus	alpha2b_on	Orthosteric Ligand	6K41-α_2b-Dexmedetomidine-Go/&β;1/&γ;2
6.67	Consensus	d1_on_allo	Orthosteric Ligand	7LJC-D₁-PubChem 86764103-Mevidalen-Gs/&β;1/&γ;2 7CKZ-D₁-Dopamine-Mevidalen-Gs/&β;1/&γ;2
6.67	Consensus	d3_on	Orthosteric Ligand	8IRT-D₃-Rotigotine-Gi1/&β;1/&γ;2 7CMV-D₃-PD128907-Gi1/&β;1/&γ;2 7CMU-D₃-Pramipexole-Gi1/&β;1/&γ;2
6.67	Consensus	dop_off_allo	Orthosteric Ligand	4N6H-δ-Naltrindole-Na
6.67	Consensus	ffa2_on	Orthosteric Ligand	8J24-FFA2-Acetic acid-Gi1/&β;1/&γ;2 8T3S-FFA2-Butyric acid-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8J22-FFA2-TUG-1375-Gi1/&β;1/&γ;2
6.67	Consensus	ghrelin_off	Orthosteric Ligand	6KO5-Ghrelin-PubChem 57400002 7F83-Ghrelin-PF-05190457
6.67	Consensus	gnrh_off	Orthosteric Ligand	gnrh1_off
6.67	Consensus	lh_on_allo	Other Ligand	7FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/&β;1/&γ;2
6.67	Consensus	m1_off_allo	Other Ligand	6WJC-M₁-Atropine-Muscarinic toxin 7
6.67	Consensus	melanocortin_on	Orthosteric Ligand	mc2_on mc1_on mc3_on mc4_on mc5_on
6.67	Consensus	nop_off	Orthosteric Ligand	4EA3-NOP-PubChem 10296561 5DHG-NOP-PubChem 25001412 5DHH-NOP-SB-612111
6.67	Consensus	ot_off	Orthosteric Ligand	6TPK-OT-Retosiban
6.67	Consensus	ox1_off	Orthosteric Ligand	6TOT-OX₁-Lemborexant 6TP4-OX₁-ACT-462206 6TP6-OX₁-Filorexant 6V9S-OX₁-GTPL11403 6TP3-OX₁-Nemorexant 6TQ6-OX₁-PubChem 145714283 6TQ7-OX₁-SB-334867 6TQ9-OX₁-SB-408124 4ZJC-OX₁-SB-674042 4ZJ8-OX₁-Suvorexant
6.67	Consensus	ox2_off	Orthosteric Ligand	6TPN-OX₂-HTL6641 7XRR-OX₂-Lemborexant
6.67	Consensus	vasopressin-ot_off	Orthosteric Ligand	ot_off
6.25	Single	2VT4	Cyanopindolol	2VT4-β₁-Cyanopindolol
6.25	Single	2Y02	Carmoterol	2Y02-β₁-Carmoterol
6.25	Single	2YCY	Cyanopindolol	2YCY-β₁-Cyanopindolol
6.25	Single	3EML	ZM241385	3EML-A_2A-ZM241385
6.25	Single	3NY8	ICI 118-551	3NY8-β₂-ICI 118-551
6.25	Single	3NYA	(S)-Alprenolol	3NYA-β₂-(S)-Alprenolol
6.25	Single	3ZPQ	4-(piperazin-1- yl)-1H-indole	3ZPQ-β₁-4-(piperazin-1- yl)-1H-indole-Na
6.25	Single	3ZPR	4-methyl-2-(piperazin-1-yl)	3ZPR-β₁-4-methyl-2-(piperazin-1-yl)-Na
6.25	Single	4EA3	PubChem 10296561	4EA3-NOP-PubChem 10296561
6.25	Single	4EIY	ZM241385	4EIY-A_2A-ZM241385-Na
6.25	Single	4EJ4	Naltrindole	4EJ4-δ-Naltrindole
6.25	Single	4GBR	(S)-Carazolol	4GBR-β₂-(S)-Carazolol
6.25	Single	4J4Q	Octyl Beta-D-Glucopyranoside	4J4Q-Rhodopsin-Octyl Beta-D-Glucopyranoside-Gt(CT)
6.25	Single	4QIM	PubChem 24905375	4QIM-SMO-PubChem 24905375
6.25	Single	4X1H	Nonyl Beta-D-Glucopyranoside	4X1H-Rhodopsin-Nonyl Beta-D-Glucopyranoside-Gt(CT)
6.25	Single	5DHG	PubChem 25001412	5DHG-NOP-PubChem 25001412
6.25	Single	5IU8	Q27456347	5IU8-A_2A-Q27456347-Na
6.25	Single	5JQH	(S)-Carazolol	5JQH-β₂-(S)-Carazolol
6.25	Single	5K2A	ZM241385	5K2A-A_2A-ZM241385-Na
6.25	Single	5OLG	ZM241385	5OLG-A_2A-ZM241385-Na
6.25	Single	5OLZ	PubChem 135566609	5OLZ-A_2A-PubChem 135566609-Na
6.25	Single	5OM1	PubChem 135566609	5OM1-A_2A-PubChem 135566609-Na
6.25	Single	5UEN	DU172	5UEN-A₁-DU172
6.25	Single	5UIG	J3.651.884G	5UIG-A_2A-J3.651.884G
6.25	Single	5VRA	ZM241385	5VRA-A_2A-ZM241385-Na
6.25	Single	6FK7	PubChem 132473034	6FK7-Rhodopsin-PubChem 132473034
6.25	Single	6FKC	PubChem 132473039	6FKC-Rhodopsin-PubChem 132473039
6.25	Single	6FKD	PubChem 137349183	6FKD-Rhodopsin-PubChem 137349183
6.25	Single	6K42	Dexmedetomidine	6K42-α_2b-Dexmedetomidine-Gi1/&β;1/&γ;2
6.25	Single	6LPJ	ZM241385	6LPJ-A_2A-ZM241385-Na
6.25	Single	6LPK	ZM241385	6LPK-A_2A-ZM241385-Na
6.25	Single	6PRZ	(S)-Alprenolol	6PRZ-β₂-(S)-Alprenolol
6.25	Single	6PS0	(S)-Carazolol	6PS0-β₂-(S)-Carazolol
6.25	Single	6PS1	Timolol	6PS1-β₂-Timolol
6.25	Single	6PS2	(S)-Alprenolol	6PS2-β₂-(S)-Alprenolol
6.25	Single	6S0L	ZM241385	6S0L-A_2A-ZM241385
6.25	Single	6TOT	Lemborexant	6TOT-OX₁-Lemborexant
6.25	Single	6XBM	25(S)-Epoxycholesterol	6XBM-SMO-25(S)-Epoxycholesterol-Gi1/&β;1/&γ;2
6.25	Single	6Z4V	NTS8-13	6Z4V-NTS₁-NTS8-13
6.25	Single	7BTS	L-Epinephrine	7BTS-β₁-L-Epinephrine
6.25	Single	7BU6	L-Norepinephrine	7BU6-β₁-L-Norepinephrine
6.25	Single	7BU7	BI167107	7BU7-β₁-BI167107
6.25	Single	7CRH	SKF83959	7CRH-D₁-SKF83959-Gs/&β;1/&γ;2
6.25	Single	7DB6	Ramelteon	7DB6-MT₁-Ramelteon-Gi1/&β;1/&γ;2
6.25	Single	7E32	Serotonin	7E32-5-HT_1D-Serotonin-Gi1/&β;1/&γ;2
6.25	Single	7EPF	NAM597	7EPF-mGlu2; mGlu2-NAM597
6.25	Single	7FIH	Org43553	7FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/&β;1/&γ;2
6.25	Single	7JVQ	Apomorphine	7JVQ-D₁-Apomorphine-Gs/&β;1/&γ;2
6.25	Single	7LJC	PubChem 86764103	7LJC-D₁-PubChem 86764103-Mevidalen-Gs/&β;1/&γ;2
6.25	Single	7M3J	NPS-2143; PO4	7M3J-CaS-NPS-2143; PO4
6.25	Single	7NA8	PubChem 178024	7NA8-Ghrelin-PubChem 178024-Gi1/&β;1/&γ;2
6.25	Single	7PYR	PSB-2115	7PYR-A_2A-PSB-2115
6.25	Single	7S0G	Isoprenaline	7S0G-β₁-Isoprenaline-chim(Gi1-CtGs)/&β;1/&γ;2
6.25	Single	7SCG	FH210	7SCG-μ-FH210-Gi1/&β;1/&γ;2
6.25	Single	7SQO	TAK-925	7SQO-OX₂-TAK-925-Gi1/&β;1/&γ;2
6.25	Single	7T2G	Mitragynine pseudoindoxyl	7T2G-μ-Mitragynine pseudoindoxyl-Gi1/&β;1/&γ;2
6.25	Single	7UL4	Alvimopan	7UL4-μ-Alvimopan
6.25	Single	7UM5	5-CT	7UM5-5-HT_5A-5-CT-chim(NtGi1-Go)/&β;1/&γ;2
6.25	Single	7UM6	Lisuride	7UM6-5-HT_5A-Lisuride-chim(NtGi1-Go)/&β;1/&γ;2
6.25	Single	7VIE	S1P	7VIE-S1P₁-S1P-Gi1/&β;1/&γ;2
6.25	Single	7X2C	Fenoldopam	7X2C-D₁-Fenoldopam-Fenoldopam-Gs/&β;1/&γ;2
6.25	Single	7X9A	Neuropeptide Y	7X9A-Y₁-Neuropeptide Y-Gi1/&β;1/&γ;2
6.25	Single	7XTC	5-CT	7XTC-5-HT₇-5-CT-Gs/&β;1/&γ;2
6.25	Single	7YU4	ONO-0740556	7YU4-LPA₁-ONO-0740556
6.25	Single	8CIC	Etrumadenant	8CIC-A_2A-Etrumadenant-Na
6.25	Single	8CU6	LJ-4517	8CU6-A_2A-LJ-4517
6.25	Single	8CU7	LJ-4517	8CU7-A_2A-LJ-4517-Na
6.25	Single	8DZS	GR89,696	8DZS-κ-GR89,696-chim(NtGi2-Gz)/&β;1/&γ;2
6.25	Single	8EFQ	Damgo	8EFQ-μ-Damgo-Gi1/&β;1/&γ;2
6.25	Single	8EJC	TAK-875	8EJC-FFA1 (GPR40)-TAK-875-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
6.25	Single	8EJK	TAK-875	8EJK-FFA1 (GPR40)-TAK-875-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
6.25	Single	8GE3	Epinephrine	8GE3-β₂-Epinephrine-Gs/&β;1/&γ;2
6.25	Single	8GEE	Epinephrine	8GEE-β₂-Epinephrine-Gs/&β;1/&γ;2
6.25	Single	8GEH	Epinephrine	8GEH-β₂-Epinephrine-Gs/&β;1/&γ;2
6.25	Single	8GFW	Epinephrine	8GFW-β₂-Epinephrine-GTP-Gs/&β;1/&γ;2
6.25	Single	8GFX	Epinephrine	8GFX-β₂-Epinephrine-GTP-Gs/&β;1/&γ;2
6.25	Single	8GFY	Epinephrine	8GFY-β₂-Epinephrine-GTP-Gs/&β;1/&γ;2
6.25	Single	8GFZ	Epinephrine	8GFZ-β₂-Epinephrine-GTP-Gs/&β;1/&γ;2
6.25	Single	8GG0	Epinephrine	8GG0-β₂-Epinephrine-GTP-Gs/&β;1/&γ;2
6.25	Single	8GG1	Epinephrine	8GG1-β₂-Epinephrine-GTP-Gs/&β;1/&γ;2
6.25	Single	8GG2	Epinephrine	8GG2-β₂-Epinephrine-GTP-Gs/&β;1/&γ;2
6.25	Single	8GG6	Epinephrine	8GG6-β₂-Epinephrine-GTP-Gs/&β;1/&γ;2
6.25	Single	8GGB	Epinephrine	8GGB-β₂-Epinephrine-GTP-Gs/&β;1/&γ;2
6.25	Single	8GGJ	Epinephrine	8GGJ-β₂-Epinephrine
6.25	Single	8GGN	Epinephrine	8GGN-β₂-Epinephrine
6.25	Single	8GGO	Epinephrine	8GGO-β₂-Epinephrine
6.25	Single	8GGU	Epinephrine	8GGU-β₂-Epinephrine
6.25	Single	8ID4	Linoleic acid	8ID4-FFA4 (GPR120)-Linoleic acid-Gi1/&β;1/&γ;2
6.25	Single	8IRT	Rotigotine	8IRT-D₃-Rotigotine-Gi1/&β;1/&γ;2
6.25	Single	8JJO	Alprenolol	8JJO-β₂-Alprenolol
6.25	Single	8JLZ	ST1936	8JLZ-5-HT₆-ST1936-Gs/&β;1/&γ;2
6.25	Single	8JT8	(R)-IHCH-7179	8JT8-5-HT_2A-(R)-IHCH-7179
6.25	Single	8SZH	Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW	8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/&β;1/&γ;2
6.25	Single	8UNM	Epinephrine	8UNM-β₂-Epinephrine-GTP-Gs/&β;1/&γ;2
6.25	Single	8UNN	Epinephrine	8UNN-β₂-Epinephrine-GTP-Gs/&β;1/&γ;2
6.25	Single	8UNP	Epinephrine	8UNP-β₂-Epinephrine-GTP-Gs/&β;1/&γ;2
6.25	Single	8X17	Namodenoson	8X17-A3A-Namodenoson-Gi1/&β;1/&γ;2
6.25	Single	8X63	Mepyramine	8X63-H₁-Mepyramine
6.25	Single	8X64	Desloratadine	8X64-H₁-Desloratadine
6.25	Consensus	5ht1d_on	Orthosteric Ligand	7E32-5-HT_1D-Serotonin-Gi1/&β;1/&γ;2
6.25	Consensus	5ht6_on	Orthosteric Ligand	7XTB-5-HT₆-Serotonin-Gs/&β;1/&γ;2 8JLZ-5-HT₆-ST1936-Gs/&β;1/&γ;2
6.25	Consensus	5ht7_on	Orthosteric Ligand	7XTC-5-HT₇-5-CT-Gs/&β;1/&γ;2
6.25	Consensus	a2_off	Orthosteric Ligand	a2a_off
6.25	Consensus	a2a_off	Orthosteric Ligand	8C9W-A_2A-Etrumadenant 3UZA-A_2A-GTPL9236 8GNG-A_2A-Istradefylline 5UIG-A_2A-J3.651.884G 8CU6-A_2A-LJ-4517 7PX4-A_2A-PSB-2113 7PYR-A_2A-PSB-2115 8DU3-A_2A-PubChem 105526064 8JWY-A_2A-PubChem 168451710 5K2D-A_2A-ZM241385
6.25	Consensus	adenosine_on	Orthosteric Ligand	a1_on a2_on
6.25	Consensus	adrenergic_on	Orthosteric Ligand	beta_on alpha_on
6.25	Consensus	alpha2_on	Orthosteric Ligand	alpha2a_on alpha2b_on
6.25	Consensus	alpha_on	Orthosteric Ligand	alpha1_on alpha2_on
6.25	Consensus	cck_off	Orthosteric Ligand	ccka_off
6.25	Consensus	ccka_off	Orthosteric Ligand	7F8Y-CCK_A-Devazepide 7F8U-CCK_A-Lintitript
6.25	Consensus	dop_off	Orthosteric Ligand	4EJ4-δ-Naltrindole
6.25	Consensus	dopamine_on	Orthosteric Ligand	d3_on d2_on d5_on d1_on
6.25	Consensus	ffa1_on	Orthosteric Ligand	8EIT-FFA1 (GPR40)-Doconexent-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2 8EJC-FFA1 (GPR40)-TAK-875-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2 8T3V-FFA1-DHA-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
6.25	Consensus	ffa_on	Orthosteric Ligand	ffa4_on ffa1_on ffa2_on ffa3_on
6.25	Consensus	gi_5ht	Orthosteric Ligand	7E2Y-5-HT_1A-Serotonin-Gi1/&β;1/&γ;2 8JSP-5-HT_1A-Ulotaront-Gi1/&β;1/&γ;2 7E32-5-HT_1D-Serotonin-Gi1/&β;1/&γ;2 7E33-5-HT_1E-BRL-54443-Gi1/&β;1/&γ;2 7EXD-5-HT_1F-Lasmiditan-Gi1/&β;1/&γ;2 7XTA-5-HT₄-Serotonin-Gi1/&β;1/&γ;2 7X5H-5-HT_5A-5-CT-Gi1/&β;1/&γ;2 7E2Z-5-HT_1A-Aripiprazole-Gi1/&β;1/&γ;2 8W8B-5-HT_1A-SEP-363856-Gi1/&β;1/&γ;2
6.25	Consensus	gi_neuropeptide	Orthosteric Ligand	7YOO-Y₂-Neuropeptide Y-Gi1/&β;1/&γ;2 7YON-Y₂-Peptide YY(3-36)-Gi1/&β;1/&γ;2 7X9C-Y₄-Pancreatic Hormone-Gi1/&β;1/&γ;2 7X9A-Y₁-Neuropeptide Y-Gi1/&β;1/&γ;2
6.25	Consensus	lipid_off	Orthosteric Ligand	cannabinoid_off leuko_off lpl_off paf_off prostanoid_off
6.25	Consensus	npy1_on	Orthosteric Ligand	7X9A-Y₁-Neuropeptide Y-Gi1/&β;1/&γ;2
6.25	Consensus	npy_on	Orthosteric Ligand	npy2_on npy4_on npy1_on
6.25	Consensus	nucleotide_off	Orthosteric Ligand	adenosine_off p2y_off
6.25	Consensus	nucleotide_on	Orthosteric Ligand	adenosine_on
6.25	Consensus	p2y12_off	Orthosteric Ligand	4NTJ-P2Y₁₂-AZD1283 7PP1-P2Y₁₂-Selatogrel
6.25	Consensus	tachykinin_off	Orthosteric Ligand	nk1_off
5.88	Single	2RH1	(S)-Carazolol	2RH1-β₂-(S)-Carazolol
5.88	Single	2YCW	(S)-Carazolol	2YCW-β₁-(S)-Carazolol
5.88	Single	4PHU	Fasiglifam	4PHU-FFA1 (GPR40)-Fasiglifam
5.88	Single	4ZJ8	Suvorexant	4ZJ8-OX₁-Suvorexant
5.88	Single	5C1M	BU72	5C1M-μ-BU72
5.88	Single	5D6L	(S)-Carazolol	5D6L-β₂-(S)-Carazolol
5.88	Single	5IUA	Q27456348	5IUA-A_2A-Q27456348-Na
5.88	Single	5N2R	PubChem 92460631; psb36	5N2R-A_2A-PubChem 92460631; psb36-Na
5.88	Single	5N2S	PSB36	5N2S-A₁-PSB36
5.88	Single	5NM2	ZM241385	5NM2-A_2A-ZM241385-Na
5.88	Single	5OM4	PubChem 135566609	5OM4-A_2A-PubChem 135566609-Na
5.88	Single	5TVN	LSD	5TVN-5-HT_2B-LSD
5.88	Single	5WQC	EMPA	5WQC-OX₂-EMPA
5.88	Single	5X7D	(S)-Carazolol	5X7D-β₂-(S)-Carazolol-PubChem 129318963
5.88	Single	5XPR	Bosentan	5XPR-ET_B-Bosentan
5.88	Single	6DDE	Damgo	6DDE-μ-Damgo-Gi1/&β;1/&γ;2
5.88	Single	6E67	BI167107	6E67-β₂-BI167107-Gs (fused)
5.88	Single	6GDG	NECA	6GDG-A_2A-NECA-Gs/&β;1/&γ;1
5.88	Single	6KUW	PubChem 57213234	6KUW-α_2c-PubChem 57213234
5.88	Single	6LPL	ZM241385	6LPL-A_2A-ZM241385-Na
5.88	Single	6PS3	(S)-Carvedilol	6PS3-β₂-(S)-Carvedilol
5.88	Single	6PS6	Timolol	6PS6-β₂-Timolol
5.88	Single	6RZ5	Zafirlukast	6RZ5-CysLT₁-Zafirlukast-Na
5.88	Single	6S0Q	ZM241385	6S0Q-A_2A-ZM241385
5.88	Single	6TO7	Suvorexant	6TO7-OX₁-Suvorexant-Na
5.88	Single	6TP6	Filorexant	6TP6-OX₁-Filorexant
5.88	Single	6W2X	PubChem 23727970	6W2X-GABA_B1, GABA_B2-PubChem 5311042-PubChem 23727970
5.88	Single	6WQA	ZM241385	6WQA-A_2A-ZM241385-Na
5.88	Single	6XBK	Cholesterol	6XBK-SMO-Cholesterol-Gi1/&β;1/&γ;2
5.88	Single	6Z4S	SR48692	6Z4S-NTS₁-SR48692
5.88	Single	6Z8N	SRI-9829	6Z8N-NTS₁-SRI-9829
5.88	Single	7BVQ	(S)-Carazolol	7BVQ-β₁-(S)-Carazolol
5.88	Single	7CFN	INT-777	7CFN-GPBA-INT-777-Gs/&β;1/&γ;2
5.88	Single	7CKX	A77636	7CKX-D₁-A77636-Gs/&β;1/&γ;2
5.88	Single	7LD3	Adenosine	7LD3-A₁-Adenosine-PubChem 25263603-Gi2/&β;1/&γ;2
5.88	Single	7M3J	NPS-2143; PO4	7M3J-CaS-NPS-2143; PO4
5.88	Single	7RM5	ZM241385	7RM5-A_2A-ZM241385-Na
5.88	Single	7S0F	Isoprenaline	7S0F-β₁-Isoprenaline-Gi1/&β;1/&γ;2
5.88	Single	7SBF	PZM21	7SBF-μ-PZM21-Gi1/&β;1/&γ;2
5.88	Single	7SIN	NPS-2143	7SIN-CaS-NPS-2143
5.88	Single	7SIN	NPS-2143	7SIN-CaS-NPS-2143
5.88	Single	7T9N	PubChem 644078	7T9N-TSH-M22 Fab-PubChem 644078-Gs/&β;1/&γ;2
5.88	Single	7VUH	JNJ-63533054	7VUH-GPR139-JNJ-63533054-chim(Gs-CtGq)/&β;1/&γ;2
5.88	Single	7VV4	Cortistatin-14	7VV4-MRGPRX2-Cortistatin-14
5.88	Single	7WC6	LSD	7WC6-5-HT_2A-LSD
5.88	Single	7WIG	L-054,264	7WIG-SST2-L-054,264-Gi1/&β;1/&γ;2
5.88	Single	7XKA	Epinephrine	7XKA-β₂-Epinephrine
5.88	Single	7Y26	Octreotide	7Y26-SST2-Octreotide-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
5.88	Single	7Y27	Somatostatin-14	7Y27-SST2-Somatostatin-14-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
5.88	Single	7YU3	ONO-0740556	7YU3-LPA₁-ONO-0740556-Gi1/&β;1/&γ;2
5.88	Single	7YU6	ONO-0740556	7YU6-LPA₁-ONO-0740556-Gi1/&β;1/&γ;2
5.88	Single	7YU7	ONO-0740556	7YU7-LPA₁-ONO-0740556-Gi1/&β;1/&γ;2
5.88	Single	8C9W	Etrumadenant	8C9W-A_2A-Etrumadenant
5.88	Single	8DZQ	momSalB	8DZQ-κ-momSalB-Go/&β;1/&γ;2
5.88	Single	8DZR	GR89,696	8DZR-κ-GR89,696-chim(NtGi2-Gt3)/&β;1/&γ;2
5.88	Single	8FN1	Neurotensin/neuromedin N	8FN1-NTS₁-Neurotensin/neuromedin N-chim(NtGi1-Go)/&β;1/&γ;2
5.88	Single	8FYN	ZM241385	8FYN-A_2A-ZM241385-Na
5.88	Single	8GNE	KW-6356	8GNE-A_2A-KW-6356-Na
5.88	Single	8K8J	Fenofibrate	8K8J-CB₁-Fenofibrate-chim(Gs-CtGq)/&β;1/&γ;2
5.88	Single	8KFX	LMD-009	8KFX-CCR8-LMD-009-Gi1/&β;1/&γ;2
5.88	Single	8QOT	Nanobody E	8QOT-μ-Nanobody E
5.88	Single	8SZG	Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW	8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-chim(NtGi1-Gq)/&β;1/&γ;2
5.88	Single	8SZI	Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW	8SZI-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi3/&β;1/&γ;2
5.88	Single	8UNY	Epinephrine	8UNY-β₂-Epinephrine-GTP-Gs/&β;1/&γ;2
5.88	Single	8WPU	Tryptophan; Cinacalcet; PO4; Ca	8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
5.88	Single	9AXF	Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4	9AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
5.88	Single	9AYF	Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4	9AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/&β;1/&γ;2
5.88	Consensus	5ht1_on	Orthosteric Ligand	5ht1a_on 5ht1d_on 5ht1e_on 5ht1f_on 5ht1b_on
5.88	Consensus	a1_off	Orthosteric Ligand	5UEN-A₁-DU172 5N2S-A₁-PSB36
5.88	Consensus	a1_on_allo	Orthosteric Ligand	7LD3-A₁-Adenosine-PubChem 25263603-Gi2/&β;1/&γ;2
5.88	Consensus	a2a_on	Orthosteric Ligand	6GDG-A_2A-NECA-Gs/&β;1/&γ;1
5.88	Consensus	adrenergic_off	Orthosteric Ligand	beta_off alpha_off
5.88	Consensus	alpha2a_on	Orthosteric Ligand	7EJ0-α_2a-L-Norepinephrine-Go/&β;1/&γ;2 7EJK-α_2a-Oxymetazoline-Go/&β;1/&γ;2 7W7E-α_2a-W58-Go/&β;1/&γ;2 7W6P-α_2a-W96-Go/&β;1/&γ;2 7EJ8-α_2a-Brimonidine-Go/&β;1/&γ;2 7EJA-α_2a-Dexmedetomidine-Go/&β;1/&γ;2
5.88	Consensus	alpha2c_off	Orthosteric Ligand	6KUW-α_2c-PubChem 57213234
5.88	Consensus	amine_off	Orthosteric Ligand	adrenergic_off histamine_off muscarinic_off 5ht_off dopamine_off
5.88	Consensus	beta2_off	Orthosteric Ligand	6PS2-β₂-(S)-Alprenolol 6PS3-β₂-(S)-Carvedilol 6PS5-β₂-(S)-Propranolol 6PS6-β₂-Timolol 2RH1-β₂-(S)-Carazolol 6PS4-β₂-ICI 118-551 3NY9-β₂-PubChem 913103
5.88	Consensus	beta2_on	Orthosteric Ligand	3SN6-β₂-BI167107-Gs/&β;1/&γ;2 7DHR-β₂-Isoprenaline-Gs/&β;1/&γ;2 7BZ2-β₂-Arformoterol-Gs/&β;1/&γ;2 7DHI-β₂-Salbutamol-Gs/&β;1/&γ;2
5.88	Consensus	beta_off	Orthosteric Ligand	beta1_off beta2_off
5.88	Consensus	d1_on	Orthosteric Ligand	7F0T-D₁-Dopamine-Gs/&β;1/&γ;2 7CKY-D₁-PW0464-Gs/&β;1/&γ;2 8IRR-D₁-Rotigotine-Gs/&β;1/&γ;2 7JV5-D₁-SKF81297-Gs/&β;1/&γ;2 7JVP-D₁-SKF83959-Gs/&β;1/&γ;2 7X2D-D₁-Tavapadon-Gs/&β;1/&γ;2 7JOZ-D₁-VFP-Gs/&β;1/&γ;2 7CKX-D₁-A77636-Gs/&β;1/&γ;2 7JVQ-D₁-Apomorphine-Gs/&β;1/&γ;2
5.88	Consensus	gi_adrenergic	Orthosteric Ligand	7S0F-β₁-Isoprenaline-Gi1/&β;1/&γ;2 6K42-α_2b-Dexmedetomidine-Gi1/&β;1/&γ;2
5.88	Consensus	go_amine	Orthosteric Ligand	go_adrenergic go_muscarinic go_5ht
5.88	Consensus	go_opioid	Orthosteric Ligand	8DZQ-κ-momSalB-Go/&β;1/&γ;2
5.88	Consensus	gs_sst	Orthosteric Ligand	7Y27-SST2-Somatostatin-14-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
5.56	Single	2YDV	NECA	2YDV-A_2A-NECA
5.56	Single	3P0G	BI167107	3P0G-β₂-BI167107
5.56	Single	3PDS	Hydroxybenzylisoproterenol	3PDS-β₂-Hydroxybenzylisoproterenol
5.56	Single	3SN6	BI167107	3SN6-β₂-BI167107-Gs/&β;1/&γ;2
5.56	Single	3ZEV	Neurotensin	3ZEV-NTS₁-Neurotensin
5.56	Single	4BV0	Neurotensin	4BV0-NTS₁-Neurotensin
5.56	Single	4DJH	JDTic	4DJH-κ-JDTic
5.56	Single	4RWA	DIPP-NH2	4RWA-δ-DIPP-NH2
5.56	Single	4RWD	DIPP-NH2	4RWD-δ-DIPP-NH2-Na
5.56	Single	4UHR	CGS21680	4UHR-A_2A-CGS21680
5.56	Single	4Z34	ONO-9780307	4Z34-LPA₁-ONO-9780307
5.56	Single	5A8E	7-Methylcyanopindolol	5A8E-β₁-7-Methylcyanopindolol-Na
5.56	Single	5D5A	(S)-Carazolol	5D5A-β₂-(S)-Carazolol
5.56	Single	5D5B	(S)-Carazolol	5D5B-β₂-(S)-Carazolol
5.56	Single	5G53	NECA	5G53-A_2A-NECA-Gs
5.56	Single	5TZR	-	5TZR-FFA1 (GPR40)-MK8666
5.56	Single	5V56	TC114	5V56-SMO-TC114
5.56	Single	5X93	K-8794	5X93-ET_B-K-8794
5.56	Single	5XRA	AM11542	5XRA-CB₁-AM11542
5.56	Single	6E59	L-760735	6E59-NK₁-L-760735
5.56	Single	6GT3	Imaradenant	6GT3-A_2A-Imaradenant-Na
5.56	Single	6H7J	Isoprenaline	6H7J-β₁-Isoprenaline
5.56	Single	6J20	Aprepitant	6J20-NK₁-Aprepitant
5.56	Single	6J21	Aprepitant	6J21-NK₁-Aprepitant
5.56	Single	6N48	BI167107	6N48-β₂-BI167107-PubChem 138454256
5.56	Single	6NI3	BI167107	6NI3-β₂-BI167107-Gs/&β;1/&γ;2
5.56	Single	6O3C	Cholesterol	6O3C-SMO-SAG21k-Cholesterol
5.56	Single	6TQ7	SB-334867	6TQ7-OX₁-SB-334867
5.56	Single	6UP7	Neurotensin	6UP7-NTS₁-Neurotensin-Arrestin2
5.56	Single	6W2X	PubChem 23727970	6W2X-GABA_B1, GABA_B2-PubChem 5311042-PubChem 23727970
5.56	Single	6WGT	LSD	6WGT-5-HT_2A-LSD
5.56	Single	6Z4Q	SR142948A	6Z4Q-NTS₁-SR142948A
5.56	Single	7AUE	Setmelanotide	7AUE-MC₄-Setmelanotide-chim(NtGi1L-Gs)/&β;1/&γ;2
5.56	Single	7CKY	PW0464	7CKY-D₁-PW0464-Gs/&β;1/&γ;2
5.56	Single	7EPE	NAM563	7EPE-mGlu-NAM563
5.56	Single	7EW4	CYM5541	7EW4-S1P₃-CYM5541-Gi1/&β;1/&γ;2
5.56	Single	7EW7	PubChem 4077460	7EW7-S1P₁-PubChem 4077460-Gi1/&β;1/&γ;2
5.56	Single	7FEE	PubMed 104895	7FEE-CB₁-PubMed 104895-ZCZ011
5.56	Single	7JJO	Isoprenaline	7JJO-β₁-Isoprenaline-Gs/&β;1/&γ;2
5.56	Single	7JV5	SKF81297	7JV5-D₁-SKF81297-Gs/&β;1/&γ;2
5.56	Single	7JVP	SKF83959	7JVP-D₁-SKF83959-Gs/&β;1/&γ;2
5.56	Single	7L0P	Neurotensin	7L0P-NTS₁-Neurotensin-Gi1/&β;1/&γ;1
5.56	Single	7L0Q	Neurotensin	7L0Q-NTS₁-Neurotensin-Gi1/&β;1/&γ;1
5.56	Single	7P2L	4YI	7P2L-mGlu₅-4YI
5.56	Single	7PX4	PSB-2113	7PX4-A_2A-PSB-2113
5.56	Single	7TD1	LPA	7TD1-LPA₁-LPA-Gi1/&β;1/&γ;2
5.56	Single	7TUY	GSK682753A	7TUY-GPR183-GSK682753A
5.56	Single	7U2L	PubChem 163201242	7U2L-μ-PubChem 163201242-Gi1/&β;1/&γ;2
5.56	Single	7W6P	W96	7W6P-α_2a-W96-Go/&β;1/&γ;2
5.56	Single	7W7E	W58	7W7E-α_2a-W58-Go/&β;1/&γ;2
5.56	Single	7WV9	PubMed 104895	7WV9-CB₁-PubMed 104895-ZCZ011-Gi2/&β;1/&γ;2
5.56	Single	7XOW	Gastrin	7XOW-CCK_B-Gastrin-Gq/&β;1/&γ;2
5.56	Single	7XOX	Cholecystokinin-8	7XOX-CCK_B-Cholecystokinin-8-Gq/&β;1/&γ;2
5.56	Single	7XWO	Neurokinin-A	7XWO-NK₂-Neurokinin-A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
5.56	Single	7Y67	C089 peptide	7Y67-C5a₁-C089 peptide-Gi1/&β;1/&γ;2
5.56	Single	7YU5	ONO-0740556	7YU5-LPA₁-ONO-0740556-Gi1/&β;1/&γ;2
5.56	Single	8DCS	Cyanopindolol	8DCS-β₁-Cyanopindolol-Gs/&β;1/&γ;2
5.56	Single	8DZP	momSalB	8DZP-κ-momSalB-Gi1/&β;1/&γ;2
5.56	Single	8E0G	BU72	8E0G-μ-BU72
5.56	Single	8EFL	SR17018	8EFL-μ-SR17018-Gi1/&β;1/&γ;2
5.56	Single	8FMZ	Neurotensin/neuromedin N	8FMZ-NTS₁-Neurotensin/neuromedin N-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
5.56	Single	8HDO	BAY 60-6583	8HDO-A_2B-BAY 60-6583-Gs/&β;1/&γ;2
5.56	Single	8HPT	C5a anaphylatoxin C-terminal peptide	8HPT-C5a₁-C5a anaphylatoxin C-terminal peptide-Go/&β;1/&γ;2
5.56	Single	8HQC	C5a anaphylatoxin	8HQC-C5a₁-C5a anaphylatoxin-Go/&β;1/&γ;2
5.56	Single	8I9A	EP54	8I9A-C3a_B-EP54-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
5.56	Single	8ID3	9-Hydroxystearic acid	8ID3-FFA4 (GPR120)-9-Hydroxystearic acid-Gi1/&β;1/&γ;2
5.56	Single	8ID6	Oleic acid	8ID6-FFA4 (GPR120)-Oleic acid-Gi1/&β;1/&γ;2
5.56	Single	8IRR	Rotigotine	8IRR-D₁-Rotigotine-Gs/&β;1/&γ;2
5.56	Single	8IRU	Rotigotine	8IRU-D₄-Rotigotine-chim(NtGi1-Gs-CtGi1)/&β;1/&γ;2
5.56	Single	8JD0	J9R	8JD0-mGlu2; mGlu3-Glutamate-J9R
5.56	Single	8JD5	BQI; HZE; PEF	8JD5-mGlu2; mGlu4-Glutamate-BQI; HZE; PEF-Gi1/&β;1/&γ;2
5.56	Single	8JXV	Clozapine	8JXV-H₄-Clozapine-Gi1/&β;1/&γ;2
5.56	Single	8SZH	Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW	8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/&β;1/&γ;2
5.56	Single	8WPU	Tryptophan; Cinacalcet; PO4; Ca	8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
5.56	Single	8X16	Piclidenoson	8X16-A3A-Piclidenoson-Gi1/&β;1/&γ;2
5.56	Single	9AYF	Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4	9AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/&β;1/&γ;2
5.56	Consensus	5ht1b_on	Orthosteric Ligand	6G79-5-HT_1B-Donitriptan-Go/&β;1/&γ;2
5.56	Consensus	5ht5_off	Orthosteric Ligand	5ht5a_off
5.56	Consensus	5ht_off	Orthosteric Ligand	5ht2_off 5ht5_off 5ht1_off
5.56	Consensus	a2_on	Orthosteric Ligand	a2a_on a2b_on
5.56	Consensus	a2b_on	Orthosteric Ligand	8HDP-A_2B-Adenosine-Gs/&β;1/&γ;2 8HDO-A_2B-BAY 60-6583-Gs/&β;1/&γ;2 7XY7-A_2B-NECA-chim(NtGi1-Gs)/&β;1/&γ;2 7XY6-A_2B-PubChem 11717831-chim(NtGi1-Gs)/&β;1/&γ;2
5.56	Consensus	adenosine_off	Orthosteric Ligand	a1_off a2_off
5.56	Consensus	arrestin2	Orthosteric Ligand	6TKO-β₁-Arformoterol-Arrestin2 6PWC-NTS₁-Neurotensin-Arrestin2 7R0C-V₂-Acyclovir triphosphate-Arrestin2
5.56	Consensus	beta1_off	Orthosteric Ligand	2VT4-β₁-Cyanopindolol 2YCZ-β₁-Iodocyanopindolol
5.56	Consensus	cck_on	Orthosteric Ligand	ccka_on cckb_on
5.56	Consensus	ccka_on	Orthosteric Ligand	7EZH-CCK_A-Cholecystokinin-8-Gi1/&β;1/&γ;2 7XOV-CCK_A-SR146131-Gs/&β;1/&γ;2
5.56	Consensus	class-a_off	Orthosteric Ligand	sensory_off amine_off lipid_off nucleotide_off peptide_off protein_off hcar_off
5.56	Consensus	cyslt1_off_ortoallo	Orthosteric Ligand	6RZ5-CysLT₁-Zafirlukast-Na 6RZ4-CysLT₁-Pranlukast-Na
5.56	Consensus	dopamine_off	Orthosteric Ligand	d3_off d2_off d4_off
5.56	Consensus	ffa4_on	Orthosteric Ligand	8H4K-FFA4-GW9508-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8ID9-FFA4 (GPR120)-Eicosapentaenoic acid-Gi1/&β;1/&γ;2 8ID4-FFA4 (GPR120)-Linoleic acid-Gi1/&β;1/&γ;2 8ID6-FFA4 (GPR120)-Oleic acid-Gi1/&β;1/&γ;2 8G59-FFA4 (GPR120)-TUG-891-Gi1/&β;1/&γ;2 8ID3-FFA4 (GPR120)-9-Hydroxystearic acid-Gi1/&β;1/&γ;2 8H4I-FFA4-Doconexent-chim(NtGi1-Gs)/&β;1/&γ;2
5.56	Consensus	gi_amine	Orthosteric Ligand	gi_5ht gi_adrenergic gi_dopamine gi_muscarinic gi_histamine
5.56	Consensus	gi_dopamine	Orthosteric Ligand	8IRT-D₃-Rotigotine-Gi1/&β;1/&γ;2 7JVR-D₂-Bromoergocryptine-Gi1/&β;1/&γ;2 8IRS-D₂-Rotigotine-Gi1/&β;1/&γ;2 7CMV-D₃-PD128907-Gi1/&β;1/&γ;2 7CMU-D₃-Pramipexole-Gi1/&β;1/&γ;2
5.56	Consensus	gi_ffa	Orthosteric Ligand	8ID6-FFA4 (GPR120)-Oleic acid-Gi1/&β;1/&γ;2 8G59-FFA4 (GPR120)-TUG-891-Gi1/&β;1/&γ;2 8ID3-FFA4 (GPR120)-9-Hydroxystearic acid-Gi1/&β;1/&γ;2 8ID9-FFA4 (GPR120)-Eicosapentaenoic acid-Gi1/&β;1/&γ;2 8ID4-FFA4 (GPR120)-Linoleic acid-Gi1/&β;1/&γ;2 8J22-FFA2-TUG-1375-Gi1/&β;1/&γ;2 8J24-FFA2-Acetic acid-Gi1/&β;1/&γ;2 8J21-FFA3-Butyric acid-Gi1/&β;1/&γ;2
5.56	Consensus	go_adrenergic	Orthosteric Ligand	7EJ0-α_2a-L-Norepinephrine-Go/&β;1/&γ;2 7EJK-α_2a-Oxymetazoline-Go/&β;1/&γ;2 7W7E-α_2a-W58-Go/&β;1/&γ;2 7W6P-α_2a-W96-Go/&β;1/&γ;2 6K41-α_2b-Dexmedetomidine-Go/&β;1/&γ;2 7EJ8-α_2a-Brimonidine-Go/&β;1/&γ;2 7EJA-α_2a-Dexmedetomidine-Go/&β;1/&γ;2
5.56	Consensus	gs_adenosine	Orthosteric Ligand	8HDP-A_2B-Adenosine-Gs/&β;1/&γ;2 8HDO-A_2B-BAY 60-6583-Gs/&β;1/&γ;2 6GDG-A_2A-NECA-Gs/&β;1/&γ;1 7XY7-A_2B-NECA-chim(NtGi1-Gs)/&β;1/&γ;2 7XY6-A_2B-PubChem 11717831-chim(NtGi1-Gs)/&β;1/&γ;2
5.56	Consensus	gs_compl-peptide	Orthosteric Ligand	8I9A-C3a_B-EP54-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
5.56	Consensus	gs_dopamine	Orthosteric Ligand	7F0T-D₁-Dopamine-Gs/&β;1/&γ;2 7CKX-D₁-A77636-Gs/&β;1/&γ;2 7JVQ-D₁-Apomorphine-Gs/&β;1/&γ;2 7CKY-D₁-PW0464-Gs/&β;1/&γ;2 8IRV-D₅-Rotigotine-chim(NtGi1-Gs)/&β;1/&γ;2 7JV5-D₁-SKF81297-Gs/&β;1/&γ;2 7JVP-D₁-SKF83959-Gs/&β;1/&γ;2 7X2D-D₁-Tavapadon-Gs/&β;1/&γ;2 7JOZ-D₁-VFP-Gs/&β;1/&γ;2
5.56	Consensus	gs_nucleotide	Orthosteric Ligand	gs_adenosine
5.56	Consensus	h1_off	Orthosteric Ligand	3RZE-H₁-Cidoxepin 8X5Y-H₁-Astemizole 8X63-H₁-Mepyramine 8X64-H₁-Desloratadine
5.56	Consensus	histamine_off	Orthosteric Ligand	h1_off
5.56	Consensus	kop_off	Orthosteric Ligand	4DJH-κ-JDTic
5.56	Consensus	lpa1_on	Orthosteric Ligand	7TD0-LPA₁-LPA-Gi1/&β;1/&γ;2 7YU3-LPA₁-ONO-0740556-Gi1/&β;1/&γ;2
5.56	Consensus	lpa_off	Orthosteric Ligand	lpa1_off
5.56	Consensus	lpa_on	Orthosteric Ligand	lpa1_on
5.56	Consensus	nk1_off	Orthosteric Ligand	6J20-NK₁-Aprepitant 6HLL-NK₁-CP99994 6E59-NK₁-L-760735
5.56	Consensus	nts1_on_allo	Orthosteric Ligand	8JPB-NTS₁-Neurotensin 8-13-PubChem 118610427; GDP; Mg-Gq; GRK2
5.56	Consensus	s1p3_on	Orthosteric Ligand	7EW3-S1P₃-S1P-Gi1/&β;1/&γ;2 7EW4-S1P₃-CYM5541-Gi1/&β;1/&γ;2 7EW2-S1P₃-Fingolimod-Gi1/&β;1/&γ;2
5.56	Consensus	sst4_on	Orthosteric Ligand	7XMT-SST4-J-2156-Gi1/&β;1/&γ;2
5.26	Single	2YCX	Cyanopindolol	2YCX-β₁-Cyanopindolol
5.26	Single	3D4S	Timolol Maleate	3D4S-β₂-Timolol Maleate
5.26	Single	4AMI	Bucindolol	4AMI-β₁-Bucindolol
5.26	Single	4GRV	Neurotensin 8-13	4GRV-NTS₁-Neurotensin 8-13
5.26	Single	4LDE	BI167107	4LDE-β₂-BI167107
5.26	Single	4N4W	SANT-1	4N4W-SMO-SANT-1
5.26	Single	4OR2	FITM	4OR2-mGlu1; mGlu1-FITM
5.26	Single	4PY0	2MeSATP	4PY0-P2Y₁₂-2MeSATP
5.26	Single	4XEE	Neurotensin	4XEE-NTS₁-Neurotensin
5.26	Single	4XES	Neurotensin	4XES-NTS₁-Neurotensin
5.26	Single	4Z36	ONO-3080573	4Z36-LPA₁-ONO-3080573
5.26	Single	5F8U	Cyanopindolol	5F8U-β₁-Cyanopindolol
5.26	Single	6H7O	Cyanopindolol	6H7O-β₁-Cyanopindolol
5.26	Single	6KQI	PubMed 104895	6KQI-CB₁-PubMed 104895-ORG27569
5.26	Single	6MXT	Salmeterol	6MXT-β₂-Salmeterol
5.26	Single	6OSA	JMV449	6OSA-NTS₁-JMV449-Gi1/&β;1/&γ;2
5.26	Single	6TKO	Arformoterol	6TKO-β₁-Arformoterol-Arrestin2
5.26	Single	6VMS	Bromoergocryptine	6VMS-D₂-Bromoergocryptine-Gi1/&β;1/&γ;2
5.26	Single	6W2Y	PubChem 23727970	6W2Y-GABAB1; GABAB1-PubChem 5311042-PubChem 23727970
5.26	Single	6W2Y	PubChem 23727970	6W2Y-GABAB1; GABAB1-PubChem 5311042-PubChem 23727970
5.26	Single	6XBL	Cholesterol	6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
5.26	Single	7EO4	BAF312	7EO4-S1P₁-BAF312-Gi1/&β;1/&γ;2
5.26	Single	7EVY	Siponimod	7EVY-S1P₁-Siponimod-Gi1/&β;1/&γ;2
5.26	Single	7EW2	Fingolimod	7EW2-S1P₃-Fingolimod-Gi1/&β;1/&γ;2
5.26	Single	7L0S	Neurotensin	7L0S-NTS₁-Neurotensin-Gi1/&β;1/γ1
5.26	Single	7L1U	Orexin	7L1U-OX₂-Orexin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
5.26	Single	7L1V	PubChem 155491009	7L1V-OX₂-PubChem 155491009-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
5.26	Single	7SUS	PubChem 122701908	7SUS-Apelin-PubChem 122701908
5.26	Single	7W0L	PubChem 122701908	7W0L-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
5.26	Single	7X1T	Taltirelin	7X1T-TRH-Taltirelin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
5.26	Single	7XMT	J-2156	7XMT-SST4-J-2156-Gi1/&β;1/&γ;2
5.26	Single	7XY7	NECA	7XY7-A_2B-NECA-chim(NtGi1-Gs)/&β;1/&γ;2
5.26	Single	7Y66	BM213	7Y66-C5a₁-BM213-Gi1/&β;1/&γ;2
5.26	Single	7YIT	Nalfurafine	7YIT-κ-Nalfurafine
5.26	Single	7YMJ	Tamsulosin	7YMJ-Alpha1A-Tamsulosin
5.26	Single	8E9W	2-Deoxycytidine	8E9W-M₃-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
5.26	Single	8H0Q	Gastrin Releasing Peptide	8H0Q-BB₂-Gastrin Releasing Peptide-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
5.26	Single	8HK2	C3a anaphylatoxin	8HK2-C3a_B-C3a anaphylatoxin-Gi1/&β;1/&γ;2
5.26	Single	8I95	EP54	8I95-C3a_B-EP54-Go/&β;1/&γ;2
5.26	Single	8I9L	C3a anaphylatoxin	8I9L-C3a_B-C3a anaphylatoxin-Go/&β;1/&γ;2
5.26	Single	8IA8	E7 peptide	8IA8-C3a_B-E7 peptide-Gi1/&β;1/&γ;2
5.26	Single	8IBU	Erythromycin A	8IBU-Motilin-Erythromycin A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
5.26	Single	8IRS	Rotigotine	8IRS-D₂-Rotigotine-Gi1/&β;1/&γ;2
5.26	Single	8IRV	Rotigotine	8IRV-D₅-Rotigotine-chim(NtGi1-Gs)/&β;1/&γ;2
5.26	Single	8J22	TUG-1375	8J22-FFA2-TUG-1375-Gi1/&β;1/&γ;2
5.26	Single	8JJ8	Formoterol	8JJ8-β₂-Formoterol
5.26	Single	8JJL	Olodaterol	8JJL-β₂-Olodaterol
5.26	Single	8JPB	Neurotensin 8-13	8JPB-NTS₁-Neurotensin 8-13-PubChem 118610427; GDP; Mg-Gq; GRK2
5.26	Single	8JWY	PubChem 168451710	8JWY-A_2A-PubChem 168451710
5.26	Single	8JWZ	AB928	8JWZ-A_2A-AB928-Na
5.26	Single	8SZH	Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW	8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/&β;1/&γ;2
5.26	Single	8T3Q	DHA	8T3Q-FFA4-DHA-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
5.26	Single	8U26	Protachykinin-1	8U26-NK₁-Protachykinin-1-Gs/&β;1/&γ;2
5.26	Consensus	adgrg_on	Orthosteric Ligand	adgrg2_on adgrg3_on
5.26	Consensus	cb1_off_allo	Orthosteric Ligand	6KQI-CB₁-PubMed 104895-ORG27569
5.26	Consensus	class-b2_on	Orthosteric Ligand	adgrg_on
5.26	Consensus	gi_class-f	Other Ligand	gi_frizzled
5.26	Consensus	gi_frizzled	Other Ligand	6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
5.26	Consensus	go_5ht	Orthosteric Ligand	6G79-5-HT_1B-Donitriptan-Go/&β;1/&γ;2 7UM5-5-HT_5A-5-CT-chim(NtGi1-Go)/&β;1/&γ;2 7UM6-5-HT_5A-Lisuride-chim(NtGi1-Go)/&β;1/&γ;2 7UM7-5-HT_5A-Methylergometrine-chim(NtGi1-Go)/&β;1/&γ;2
5.26	Consensus	gs_amine	Orthosteric Ligand	gs_5ht gs_adrenergic gs_dopamine gs_histamine gs_muscarinic gs_tar
5.26	Consensus	leuko_off	Orthosteric Ligand	blt_off cyslt_off
5.26	Consensus	lpa1_off	Orthosteric Ligand	4Z36-LPA₁-ONO-3080573 4Z34-LPA₁-ONO-9780307 4Z35-LPA₁-ONO-9910539 7YU4-LPA₁-ONO-0740556
5.26	Consensus	mop_on	Orthosteric Ligand	8F7Q-μ-Beta-endorphin-Gi1/&β;1/&γ;2 8EFQ-μ-Damgo-Gi1/&β;1/&γ;2 8F7R-μ-Endomorphin-Gi1/&β;1/&γ;2 8EF5-μ-Fentanyl-Gi1/&β;1/&γ;2 8EF6-μ-Morphine-Gi1/&β;1/&γ;2 8EFB-μ-Oliceridine-Gi1/&β;1/&γ;2 8EFO-μ-PZM21-Gi1/&β;1/&γ;2 8EFL-μ-SR17018-Gi1/&β;1/&γ;2
5.26	Consensus	nts1_off	Orthosteric Ligand	6Z4Q-NTS₁-SR142948A 6Z4S-NTS₁-SR48692
5.26	Consensus	nts1_on	Orthosteric Ligand	6OS9-NTS₁-JMV449-Gi1/&β;1/&γ;2
5.26	Consensus	nts_off	Orthosteric Ligand	nts1_off
5.26	Consensus	nts_on	Orthosteric Ligand	nts1_on
5.26	Consensus	opioid_off	Orthosteric Ligand	kop_off mop_off nop_off dop_off
5.26	Consensus	peptide_off	Orthosteric Ligand	opioid_off angiotensin_off bombesin_off cck_off endothelin_off ghrelin_off npy_off nts_off orexin_off vasopressin-ot_off tachykinin_off sst_off
5.00	Single	2YCZ	Iodocyanopindolol	2YCZ-β₁-Iodocyanopindolol
5.00	Single	4BUO	Neurotensin	4BUO-NTS₁-Neurotensin
5.00	Single	4BVN	Cyanopindolol	4BVN-β₁-Cyanopindolol-Na
5.00	Single	4OR2	FITM	4OR2-mGlu1; mGlu1-FITM
5.00	Single	4Z35	ONO-9910539	4Z35-LPA₁-ONO-9910539
5.00	Single	5TZY	MK8666; PubChem 127053597	5TZY-FFA1 (GPR40)-MK8666; PubChem 127053597
5.00	Single	6BQG	Ergotamine	6BQG-5-HT_2C-Ergotamine
5.00	Single	6DDF	Damgo	6DDF-μ-Damgo-Gi1/&β;1/&γ;2
5.00	Single	6G79	Donitriptan	6G79-5-HT_1B-Donitriptan-Go/&β;1/&γ;2
5.00	Single	6H7L	Dobutamine	6H7L-β₁-Dobutamine
5.00	Single	6IBL	Arformoterol	6IBL-β₁-Arformoterol
5.00	Single	6K1Q	IRL2500	6K1Q-ET_B-IRL2500
5.00	Single	6OS9	JMV449	6OS9-NTS₁-JMV449-Gi1/&β;1/&γ;2
5.00	Single	7EVZ	Cenerimod	7EVZ-S1P₁-Cenerimod-Gi1/&β;1/&γ;2
5.00	Single	7EW0	Ozanimod	7EW0-S1P₁-Ozanimod-Gi1/&β;1/&γ;2
5.00	Single	7EZC	UKA	7EZC-A_2A-UKA
5.00	Single	7EZH	Cholecystokinin-8	7EZH-CCK_A-Cholecystokinin-8-Gi1/&β;1/&γ;2
5.00	Single	7EZM	Cholecystokinin-8	7EZM-CCK_A-Cholecystokinin-8-chim(NtGsL-Gq)/&β;1/&γ;2
5.00	Single	7MBY	Cholecystokinin-8	7MBY-CCK_A-Cholecystokinin-8-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
5.00	Single	7MTS	ADX55164	7MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/&β;1/&γ;2
5.00	Single	7P00	Substance P	7P00-NK₁-Substance P-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
5.00	Single	7QVM	Oxytocin	7QVM-OT-Oxytocin-chim(NtGi1-Go-CtGq)/&β;1/&γ;2
5.00	Single	7UM4	AS2674723	7UM4-5-HT_5A-AS2674723
5.00	Single	7WVV	fMLFII	7WVV-FPR2-ALX-fMLFII-Gi2/&β;1/&γ;2
5.00	Single	7X2D	Tavapadon	7X2D-D₁-Tavapadon-Gs/&β;1/&γ;2
5.00	Single	7XAV	Lanreotide	7XAV-SST2-Lanreotide-Gi1/&β;1/&γ;2
5.00	Single	7YU8	ONO-0740556	7YU8-LPA₁-ONO-0740556-Gi1/&β;1/&γ;2
5.00	Single	8E9X	2-Deoxycytidine	8E9X-M₄-2-Deoxycytidine-chim(NtGi1-Go)/&β;1/&γ;2
5.00	Single	8E9Y	PubChem 446603	8E9Y-M₃-PubChem 446603-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
5.00	Single	8FX5	Xanomeline	8FX5-M₄-Xanomeline-Xanomeline-Gi1/&β;1/&γ;2
5.00	Single	8GUT	LEI-102	8GUT-CB₂-LEI-102-Gi1/&β;1/&γ;2
5.00	Single	8ID8	TUG-891	8ID8-FFA4 (GPR120)-TUG-891-Gi1/&β;1/&γ;2
5.00	Single	8IYS	TUG-891	8IYS-FFA4-TUG-891-GDP-chim(NtGi1L-Gq)/&β;1/&γ;2
5.00	Single	8JPF	Neurotensin	8JPF-NTS₁-Neurotensin-PubChem 118610427
5.00	Single	8T3O	TUG-891	8T3O-FFA4-TUG-891-2Y5-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
5.00	Single	8WRZ	8D0	8WRZ-CB₁-8D0-Arrestin1
5.00	Consensus	5ht5a_off	Orthosteric Ligand	7UM4-5-HT_5A-AS2674723
5.00	Consensus	beta1_off_allo	Orthosteric Ligand	4BVN-β₁-Cyanopindolol-Na
5.00	Consensus	cckb_on	Orthosteric Ligand	7XOW-CCK_B-Gastrin-Gq/&β;1/&γ;2 7F8W-CCK_B-Gastrin-17-chim(NtGsL-Gq)/&β;1/&γ;2 8IA7-CCK_B-Cholecystokinin-8-chim(NtGi1L-Gq)/&β;1/&γ;2
5.00	Consensus	endothelin_off	Orthosteric Ligand	etb_off
5.00	Consensus	etb_off	Orthosteric Ligand	5XPR-ET_B-Bosentan 6K1Q-ET_B-IRL2500 5X93-ET_B-K-8794
5.00	Consensus	ffa4_on_allo	Orthosteric Ligand	8T3O-FFA4-TUG-891-2Y5-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
5.00	Consensus	gi_class-a	Orthosteric Ligand	gi_amine gi_lipid gi_melatonin gi_peptide gi_protein gi_nucleotide gi_hcar
5.00	Consensus	gi_neurotensin	Orthosteric Ligand	7L0P-NTS₁-Neurotensin-Gi1/&β;1/&γ;1 6OS9-NTS₁-JMV449-Gi1/&β;1/&γ;2
5.00	Consensus	gs_cck	Orthosteric Ligand	7MBX-CCK_A-Cholecystokinin-8-Gs/&β;1/&γ;1 7XOV-CCK_A-SR146131-Gs/&β;1/&γ;2
5.00	Consensus	gs_orexin	Orthosteric Ligand	7L1U-OX₂-Orexin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7L1V-OX₂-PubChem 155491009-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7SR8-OX₂-TAK-925-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
5.00	Consensus	nk2_on	Orthosteric Ligand	7XWO-NK₂-Neurokinin-A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
5.00	Consensus	orexin_on	Orthosteric Ligand	ox2_on
5.00	Consensus	ot_on	Orthosteric Ligand	7QVM-OT-Oxytocin-chim(NtGi1-Go-CtGq)/&β;1/&γ;2
5.00	Consensus	s1p1_on	Orthosteric Ligand	7TD3-S1P₁-S1P-Gi1/&β;1/&γ;2 7TD4-S1P₁-Siponimod-Gi1/&β;1/&γ;2 7VIF-S1P₁-(S)-FTY720-P-Gi1/&β;1/&γ;2 7EO4-S1P₁-BAF312-Gi1/&β;1/&γ;2 7VIG-S1P₁-CBP-307-Gi1/&β;1/&γ;2 7EVZ-S1P₁-Cenerimod-Gi1/&β;1/&γ;2 7EW0-S1P₁-Ozanimod-Gi1/&β;1/&γ;2 7EW7-S1P₁-PubChem 4077460-Gi1/&β;1/&γ;2
4.76	Single	3NY9	PubChem 913103	3NY9-β₂-PubChem 913103
4.76	Single	4UG2	CGS21680	4UG2-A_2A-CGS21680
4.76	Single	5WF6	UK-432097	5WF6-A_2A-UK-432097
4.76	Single	5ZTY	AM10257	5ZTY-CB₂-AM10257
4.76	Single	6C1Q	PMX53	6C1Q-C5a₁-PMX53-NDT9513727
4.76	Single	6PT3	DPI-287	6PT3-δ-DPI-287
4.76	Single	6XBJ	Cholesterol	6XBJ-SMO-Cholesterol-Gi1/&β;1/&γ;2
4.76	Single	7F2O	Bradykinin	7F2O-BK₂-Bradykinin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
4.76	Single	7F8W	Gastrin-17	7F8W-CCK_B-Gastrin-17-chim(NtGsL-Gq)/&β;1/&γ;2
4.76	Single	7MTR	ADX55164	7MTR-mGlu2; mGlu2-Glutamate-ADX55164
4.76	Single	7NA7	Ghrelin-27	7NA7-Ghrelin-Ghrelin-27-Gi1/&β;1/&γ;2
4.76	Single	7RKN	Fractalkine	7RKN-US28-Fractalkine-Gi1/&β;1/&γ;2
4.76	Single	7RMG	Substance P	7RMG-NK₁-Substance P-chim(Gs-CtGq)/&β;1/&γ;2
4.76	Single	7W2Z	Ghrelin	7W2Z-Ghrelin-Ghrelin-Go/&β;1/&γ;2
4.76	Single	7X1U	TRH	7X1U-TRH-TRH-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
4.76	Single	7XN9	L-054,522	7XN9-SST2-L-054,522
4.76	Single	7XY6	PubChem 11717831	7XY6-A_2B-PubChem 11717831-chim(NtGi1-Gs)/&β;1/&γ;2
4.76	Single	7Y1F	Dynorphin	7Y1F-κ-Dynorphin-Gi1/&β;1/&γ;2
4.76	Single	7YAE	Octreotide	7YAE-SST2-Octreotide-Gi1/&β;1/&γ;2
4.76	Single	8F7R	Endomorphin	8F7R-μ-Endomorphin-Gi1/&β;1/&γ;2
4.76	Single	8IA7	Cholecystokinin-8	8IA7-CCK_B-Cholecystokinin-8-chim(NtGi1L-Gq)/&β;1/&γ;2
4.76	Single	8INR	Alpha-MSH	8INR-MC₅-Alpha-MSH-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
4.76	Single	8JBF	Senktide	8JBF-NK₃-Senktide-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
4.76	Single	8X5Y	Astemizole	8X5Y-H₁-Astemizole
4.76	Consensus	c3a_on	Orthosteric Ligand	8HK2-C3a_B-C3a anaphylatoxin-Gi1/&β;1/&γ;2 8IA8-C3a_B-E7 peptide-Gi1/&β;1/&γ;2 8J6D-C3a_B-EP141-Go/&β;1/&γ;2 8I95-C3a_B-EP54-Go/&β;1/&γ;2
4.76	Consensus	cb2_off	Orthosteric Ligand	5ZTY-CB₂-AM10257
4.76	Consensus	dop_on	Orthosteric Ligand	8F7S-δ-Deltorphin-Gi1/&β;1/&γ;2
4.76	Consensus	gi_apelin	Orthosteric Ligand	7W0P-Apelin-Elabela-Gi1/&β;1/&γ;2 7W0M-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
4.76	Consensus	gi_lipid	Orthosteric Ligand	gi_cannabinoid gi_prostanoid gi_ffa gi_lpl gi_leukotriene
4.76	Consensus	go_compl-peptide	Orthosteric Ligand	8I95-C3a_B-EP54-Go/&β;1/&γ;2 8IA2-C5a₁-C5a anaphylatoxin-Go/&β;1/&γ;2 8I9L-C3a_B-C3a anaphylatoxin-Go/&β;1/&γ;2 8J6D-C3a_B-EP141-Go/&β;1/&γ;2
4.76	Consensus	go_ghrelin	Orthosteric Ligand	7W2Z-Ghrelin-Ghrelin-Go/&β;1/&γ;2
4.76	Consensus	go_vasopressin	Orthosteric Ligand	7QVM-OT-Oxytocin-chim(NtGi1-Go-CtGq)/&β;1/&γ;2
4.76	Consensus	gq_cck	Orthosteric Ligand	8IA7-CCK_B-Cholecystokinin-8-chim(NtGi1L-Gq)/&β;1/&γ;2 7F8W-CCK_B-Gastrin-17-chim(NtGsL-Gq)/&β;1/&γ;2 7EZM-CCK_A-Cholecystokinin-8-chim(NtGsL-Gq)/&β;1/&γ;2 7XOW-CCK_B-Gastrin-Gq/&β;1/&γ;2
4.76	Consensus	gs_adgr	Orthosteric Ligand	7XKD-ADGRG2-Betahydroxyandrosterone-Gs/&β;1/&γ;2 7WUI-ADGRG2-IP15-chim(NtGi1-Gs)/&β;1/&γ;2
4.76	Consensus	gs_bombesin	Orthosteric Ligand	8H0Q-BB₂-Gastrin Releasing Peptide-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8H0P-BB₁-NMB30-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
4.76	Consensus	gs_class-b2	Orthosteric Ligand	gs_adgr
4.76	Consensus	lpl_off	Orthosteric Ligand	s1p_off lpa_off
4.76	Consensus	lpl_on	Orthosteric Ligand	s1p_on lpa_on
4.76	Consensus	motilin_on	Orthosteric Ligand	8IBV-Motilin-Motilin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IBU-Motilin-Erythromycin A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
4.76	Consensus	nk1_on	Orthosteric Ligand	8U26-NK₁-Protachykinin-1-Gs/&β;1/&γ;2 7P00-NK₁-Substance P-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
4.76	Consensus	ox2_on	Orthosteric Ligand	7L1V-OX₂-PubChem 155491009-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7L1U-OX₂-Orexin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7SR8-OX₂-TAK-925-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
4.76	Consensus	ste2_off	Orthosteric Ligand	7QA8-STE2-Peptide
4.55	Single	4AMJ	(S)-Carvedilol	4AMJ-β₁-(S)-Carvedilol
4.55	Single	4IAR	Ergotamine	4IAR-5-HT_1B-Ergotamine
4.55	Single	5VBL	Apelin Mimetic Peptide Agonist	5VBL-Apelin-Apelin Mimetic Peptide Agonist
4.55	Single	6WIV	PubChem 52923113; PubChem 52924645	6WIV-GABA_B1, GABA_B2-PubChem 52923113; PubChem 52924645
4.55	Single	7F4I	SHU9119	7F4I-MC₁-SHU9119-chim(NtGi1-Gs)/&β;1/&γ;2
4.55	Single	7F8X	NN9056	7F8X-CCK_A-NN9056
4.55	Single	7L0R	Neurotensin	7L0R-NTS₁-Neurotensin-Gi1/&β;1/&γ;1
4.55	Single	7RMH	Substance P	7RMH-NK₁-Substance P-Gs/&β;1/&γ;2
4.55	Single	7TD4	Siponimod	7TD4-S1P₁-Siponimod-Gi1/&β;1/&γ;2
4.55	Single	7W0P	Elabela	7W0P-Apelin-Elabela-Gi1/&β;1/&γ;2
4.55	Single	7W53	Neuromedin-U-25	7W53-NMUR1-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
4.55	Single	7WKD	TRH	7WKD-TRH-TRH-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
4.55	Single	7XMR	Somatostatin-14	7XMR-SST2-Somatostatin-14-Gi1/&β;1/&γ;2
4.55	Single	8DCR	Dobutamine	8DCR-β₁-Dobutamine-Gs/&β;1/&γ;2
4.55	Single	8F7X	Nociceptin	8F7X-NOP-Nociceptin-Gi1/&β;1/&γ;2
4.55	Single	8GHV	PubChem 145964903	8GHV-CB₁-PubChem 145964903-Gi1/&β;1/&γ;2
4.55	Consensus	apelin_on	Orthosteric Ligand	7W0P-Apelin-Elabela-Gi1/&β;1/&γ;2 7W0M-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
4.55	Consensus	gi_ghrelin	Orthosteric Ligand	7NA7-Ghrelin-Ghrelin-27-Gi1/&β;1/&γ;2 7NA8-Ghrelin-PubChem 178024-Gi1/&β;1/&γ;2
4.55	Consensus	gi_opioid	Orthosteric Ligand	8EF6-μ-Morphine-Gi1/&β;1/&γ;2 8F7Q-μ-Beta-endorphin-Gi1/&β;1/&γ;2 7U2K-μ-C6-guano-Gi1/&β;1/&γ;2 8EFQ-μ-Damgo-Gi1/&β;1/&γ;2 8F7S-δ-Deltorphin-Gi1/&β;1/&γ;2 8F7W-κ-Dynorphin-Gi1/&β;1/&γ;2 8F7R-μ-Endomorphin-Gi1/&β;1/&γ;2 8EF5-μ-Fentanyl-Gi1/&β;1/&γ;2 7SCG-μ-FH210-Gi1/&β;1/&γ;2 7T2H-μ-Lofentanil-Gi1/&β;1/&γ;2 7T2G-μ-Mitragynine pseudoindoxyl-Gi1/&β;1/&γ;2 8DZP-κ-momSalB-Gi1/&β;1/&γ;2 8F7X-NOP-Nociceptin-Gi1/&β;1/&γ;2 8EFB-μ-Oliceridine-Gi1/&β;1/&γ;2 8FEG-κ-PRD_002517-Gi1/&β;1/&γ;2 7U2L-μ-PubChem 163201242-Gi1/&β;1/&γ;2 8EFO-μ-PZM21-Gi1/&β;1/&γ;2 8EFL-μ-SR17018-Gi1/&β;1/&γ;2
4.55	Consensus	go_class-a	Orthosteric Ligand	go_amine go_peptide go_protein
4.55	Consensus	mop_off	Orthosteric Ligand	7UL4-μ-Alvimopan 4DKL-μ-Beta-funaltrexamine 8QOT-μ-Nanobody E
4.55	Consensus	nop_on	Orthosteric Ligand	8F7X-NOP-Nociceptin-Gi1/&β;1/&γ;2
4.55	Consensus	sst_on	Orthosteric Ligand	sst2_on sst4_on
4.55	Consensus	ste2_off	Orthosteric Ligand	7QA8-STE2-Peptide
4.35	Single	3QAK	UK-432097	3QAK-A_2A-UK-432097
4.35	Single	4IB4	Ergotamine	4IB4-5-HT_2B-Ergotamine
4.35	Single	6HLO	Aprepitant	6HLO-NK₁-Aprepitant
4.35	Single	7CUM	Phospholipid	7CUM-GABA_B1, GABA_B2-CGP54626-Phospholipid
4.35	Single	7CUM	Phospholipid	7CUM-GABA_B1, GABA_B2-CGP54626-Phospholipid
4.35	Single	7DDZ	JNJ-31020028	7DDZ-Y₂-JNJ-31020028
4.35	Single	7EZK	Cholecystokinin-8	7EZK-CCK_A-Cholecystokinin-8-chim(NtGi1-Gs)/&β;1/&γ;2
4.35	Single	7RMI	Substance P	7RMI-NK₁-Substance P-chim(Gs-CtGq)/&β;1/&γ;2
4.35	Single	8F7Q	Beta-endorphin	8F7Q-μ-Beta-endorphin-Gi1/&β;1/&γ;2
4.35	Single	8F7S	Deltorphin	8F7S-δ-Deltorphin-Gi1/&β;1/&γ;2
4.35	Single	8F7W	Dynorphin	8F7W-κ-Dynorphin-Gi1/&β;1/&γ;2
4.35	Single	8IBV	Motilin	8IBV-Motilin-Motilin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
4.35	Consensus	gi_cck	Orthosteric Ligand	7EZH-CCK_A-Cholecystokinin-8-Gi1/&β;1/&γ;2 7F8V-CCK_B-Gastrin-17-Gi2/&β;1/&γ;2
4.35	Consensus	gi_lpl	Orthosteric Ligand	7EW3-S1P₃-S1P-Gi1/&β;1/&γ;2 7TD4-S1P₁-Siponimod-Gi1/&β;1/&γ;2 7VIF-S1P₁-(S)-FTY720-P-Gi1/&β;1/&γ;2 7EO4-S1P₁-BAF312-Gi1/&β;1/&γ;2 7VIG-S1P₁-CBP-307-Gi1/&β;1/&γ;2 7EVZ-S1P₁-Cenerimod-Gi1/&β;1/&γ;2 7EW4-S1P₃-CYM5541-Gi1/&β;1/&γ;2 7EW2-S1P₃-Fingolimod-Gi1/&β;1/&γ;2 7TD0-LPA₁-LPA-Gi1/&β;1/&γ;2 7YU3-LPA₁-ONO-0740556-Gi1/&β;1/&γ;2 7EW0-S1P₁-Ozanimod-Gi1/&β;1/&γ;2 7EW7-S1P₁-PubChem 4077460-Gi1/&β;1/&γ;2
4.35	Consensus	npy2_off	Orthosteric Ligand	7DDZ-Y₂-JNJ-31020028
4.35	Consensus	vasopressin-ot_on	Orthosteric Ligand	ot_on v2_on
4.17	Single	5WF5	UK-432097	5WF5-A_2A-UK-432097
4.17	Single	6PT2	KGCHM07	6PT2-δ-KGCHM07
4.17	Single	7F4D	Alpha-MSH	7F4D-MC₁-Alpha-MSH-chim(NtGi1-Gs)/&β;1/&γ;2
4.17	Single	7F4H	Afamelanotide	7F4H-MC₁-Afamelanotide-chim(NtGi1-Gs)/&β;1/&γ;2
4.17	Single	7MBX	Cholecystokinin-8	7MBX-CCK_A-Cholecystokinin-8-Gs/&β;1/&γ;1
4.17	Single	7O7F	(6P4)CCL5	7O7F-CCR5-(6P4)CCL5-Gi1/&β;1/&γ;1
4.17	Single	7T6T	fMLFII	7T6T-FPR1-ALX-fMLFII-Gi1/&β;1/&γ;2
4.17	Single	7TD0	LPA	7TD0-LPA₁-LPA-Gi1/&β;1/&γ;2
4.17	Single	7TD2	LPA	7TD2-LPA₁-LPA-Gi1/&β;1/&γ;2
4.17	Single	7W55	Neuromedin-U-25	7W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
4.17	Consensus	go_peptide	Orthosteric Ligand	go_opioid go_ghrelin go_compl-peptide go_galanin go_vasopressin
4.17	Consensus	gs_class-a	Orthosteric Ligand	gs_amine gs_nucleotide gs_lipid gs_peptide gs_protein gs_steroid
4.17	Consensus	gs_motilin	Orthosteric Ligand	8IBV-Motilin-Motilin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IBU-Motilin-Erythromycin A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
4.17	Consensus	gs_tachykinin	Orthosteric Ligand	8U26-NK₁-Protachykinin-1-Gs/&β;1/&γ;2 7XWO-NK₂-Neurokinin-A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7P00-NK₁-Substance P-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
4.17	Consensus	mc5_on	Orthosteric Ligand	8INR-MC₅-Alpha-MSH-Ca-chim(NtGi1-Gs)/&β;1/&γ;2 8IOD-MC₅-PG-901-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
4.17	Consensus	opioid_on	Orthosteric Ligand	kop_on mop_on nop_on dop_on
4.17	Consensus	tachykinin_on	Orthosteric Ligand	nk1_on nk2_on
4.00	Single	5WB2	CX3CL1.35	5WB2-US28-CX3CL1.35
4.00	Single	5YQZ	Glucagon analogue	5YQZ-Glucagon-Glucagon analogue
4.00	Single	6MEO	Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4	6MEO-CCR5-Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4
4.00	Single	6MET	Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4	6MET-CCR5-Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4
4.00	Single	6WIV	PubChem 52923113; PubChem 52924645	6WIV-GABA_B1, GABA_B2-PubChem 52923113; PubChem 52924645
4.00	Single	7C61	Ergotamine	7C61-5-HT_1B-Ergotamine
4.00	Single	7DW9	Acyclovir triphosphate	7DW9-V₂-Acyclovir triphosphate-chim(NtGi1-Gs)/&β;1/&γ;2
4.00	Single	7W40	Bombesin	7W40-BB₂-Bombesin-chim(NtGi1L-Gq)/&β;1/&γ;2
4.00	Single	7WUI	IP15	7WUI-ADGRG2-IP15-chim(NtGi1-Gs)/&β;1/&γ;2
4.00	Single	7YON	Peptide YY(3-36)	7YON-Y₂-Peptide YY(3-36)-Gi1/&β;1/&γ;2
4.00	Single	8H4K	GW9508	8H4K-FFA4-GW9508-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
4.00	Single	8IA2	C5a anaphylatoxin	8IA2-C5a₁-C5a anaphylatoxin-Go/&β;1/&γ;2
4.00	Consensus	bk2_on	Orthosteric Ligand	7F2O-BK₂-Bradykinin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7F6I-BK₂-Kallidin-Gq/&β;1/&γ;2
4.00	Consensus	compl-peptide_on	Orthosteric Ligand	c5a1_on c3a_on
4.00	Consensus	nmur2_on	Orthosteric Ligand	7W57-NMUR2-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
4.00	Consensus	nmur_on	Orthosteric Ligand	nmur1_on nmur2_on
4.00	Consensus	v2_on	Orthosteric Ligand	7DW9-V₂-Acyclovir triphosphate-chim(NtGi1-Gs)/&β;1/&γ;2
3.85	Single	7F6H	Bradykinin	7F6H-BK₂-Bradykinin-Gq/&β;1/&γ;2
3.85	Single	7F6I	Kallidin	7F6I-BK₂-Kallidin-Gq/&β;1/&γ;2
3.85	Single	7F9Y	Ghrelin-28	7F9Y-Ghrelin-Ghrelin-28-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
3.85	Single	7P02	Protachykinin-1	7P02-NK₁-Protachykinin-1-chim(NtGi1-Gs)/&β;1/&γ;2
3.85	Single	7Y64	C5a anaphylatoxin	7Y64-C5a₁-C5a anaphylatoxin-Gi1/&β;1/&γ;2
3.85	Single	8HCX	Endothelin-1	8HCX-ET_B-Endothelin-1-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
3.85	Single	8HK5	Complement C5	8HK5-C5a₁-Complement C5-Gi1/&β;1/&γ;2
3.85	Consensus	bombesin_on	Orthosteric Ligand	bb2_on bb1_on
3.85	Consensus	c5a1_on	Orthosteric Ligand	7Y65-C5a₁-C5a peptide-Gi1/&β;1/&γ;2 8HK5-C5a₁-Complement C5-Gi1/&β;1/&γ;2 7Y66-C5a₁-BM213-Gi1/&β;1/&γ;2 7Y67-C5a₁-C089 peptide-Gi1/&β;1/&γ;2 7Y64-C5a₁-C5a anaphylatoxin-Gi1/&β;1/&γ;2
3.85	Consensus	gq_class-a	Orthosteric Ligand	gq_amine gq_peptide
3.85	Consensus	gs_bradykinin	Orthosteric Ligand	7F2O-BK₂-Bradykinin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7EIB-BK₁-Des-Arg10-Kallidin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
3.85	Consensus	gs_neuromedin	Orthosteric Ligand	7W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7W56-NMUR1-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7W57-NMUR2-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
3.85	Consensus	mc1_on	Orthosteric Ligand	7F4H-MC₁-Afamelanotide-chim(NtGi1-Gs)/&β;1/&γ;2 7F4D-MC₁-Alpha-MSH-chim(NtGi1-Gs)/&β;1/&γ;2 7F4I-MC₁-SHU9119-chim(NtGi1-Gs)/&β;1/&γ;2
3.70	Single	5UIW	5P7-CCL5	5UIW-CCR5-5P7-CCL5
3.70	Single	7F8V	Gastrin-17	7F8V-CCK_B-Gastrin-17-Gi2/&β;1/&γ;2
3.70	Single	7W3Z	Gastrin Releasing Peptide	7W3Z-BB₂-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/&β;1/&γ;2
3.70	Single	7W57	Neuromedin-S	7W57-NMUR2-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
3.70	Single	8H0P	NMB30	8H0P-BB₁-NMB30-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
3.70	Consensus	bb1_on	Orthosteric Ligand	8H0P-BB₁-NMB30-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
3.70	Consensus	bradykinin_on	Orthosteric Ligand	bk2_on bk1_on
3.70	Consensus	ccr5_off	Orthosteric Ligand	5UIW-CCR5-5P7-CCL5
3.70	Consensus	ccr5_on	Orthosteric Ligand	7O7F-CCR5-(6P4)CCL5-Gi1/&β;1/&γ;1 7F1Q-CCR5-MIP-1a-Gi1/&β;1/&γ;2
3.70	Consensus	ctlike_on	Orthosteric Ligand	6E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/&β;1/&γ;2; RAMP1 6UUN-CT Like (AM1)-Adrenomedullin-Gs/&β;1/&γ;2; RAMP2
3.70	Consensus	gi_compl-peptide	Orthosteric Ligand	8HK5-C5a₁-Complement C5-Gi1/&β;1/&γ;2 8IA8-C3a_B-E7 peptide-Gi1/&β;1/&γ;2 7Y66-C5a₁-BM213-Gi1/&β;1/&γ;2 7Y67-C5a₁-C089 peptide-Gi1/&β;1/&γ;2 8HK2-C3a_B-C3a anaphylatoxin-Gi1/&β;1/&γ;2 7Y64-C5a₁-C5a anaphylatoxin-Gi1/&β;1/&γ;2 7Y65-C5a₁-C5a peptide-Gi1/&β;1/&γ;2
3.70	Consensus	gi_neuromedin	Orthosteric Ligand	7XK8-NMUR2-Neuromedin-U-25-Gi1/&β;1/&γ;2
3.70	Consensus	kop_on	Orthosteric Ligand	8F7W-κ-Dynorphin-Gi1/&β;1/&γ;2 8DZR-κ-GR89,696-chim(NtGi2-Gt3)/&β;1/&γ;2 8DZP-κ-momSalB-Gi1/&β;1/&γ;2 8FEG-κ-PRD_002517-Gi1/&β;1/&γ;2
3.57	Single	7F4F	Afamelanotide	7F4F-MC₁-Afamelanotide-chim(NtGi1-Gs)/&β;1/&γ;2
3.57	Single	7XK8	Neuromedin-U-25	7XK8-NMUR2-Neuromedin-U-25-Gi1/&β;1/&γ;2
3.57	Consensus	ccr8_on	Orthosteric Ligand	8U1U-CCR8-CCL1-Gi1/&β;1/&γ;2
3.57	Consensus	endothelin_on	Orthosteric Ligand	etb_on eta_on
3.57	Consensus	etb_on	Orthosteric Ligand	8HCX-ET_B-Endothelin-1-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8HBD-ET_B-IRL1620-Gi1/&β;1/&γ;2
3.45	Single	6IGL	IRL1620	6IGL-ET_B-IRL1620
3.45	Single	8FEG	PRD_002517	8FEG-κ-PRD_002517-Gi1/&β;1/&γ;2
3.45	Single	8IY5	Endothelin-1	8IY5-ET_B-Endothelin-1-Gi1/&β;1/&γ;2
3.45	Single	8IY6	Endothelin-1	8IY6-ET_B-Endothelin-1
3.45	Consensus	gq_bradykinin	Orthosteric Ligand	7F6H-BK₂-Bradykinin-Gq/&β;1/&γ;2 7F6I-BK₂-Kallidin-Gq/&β;1/&γ;2
3.45	Consensus	gq_peptide	Orthosteric Ligand	gq_cck gq_angiotensin gq_bombesin gq_bradykinin
3.45	Consensus	gs_endothelin	Orthosteric Ligand	8HCQ-ET_A-Endothelin-1-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8HCX-ET_B-Endothelin-1-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
3.45	Consensus	gs_peptide	Orthosteric Ligand	gs_cck gs_motilin gs_neuromedin gs_orexin gs_sst gs_tachykinin gs_trh gs_vasopressin-ot gs_bombesin gs_bradykinin gs_compl-peptide gs_endothelin gs_galanin gs_ghrelin gs_melanocortin
3.45	Consensus	peptide_on	Orthosteric Ligand	opioid_on angiotensin_on bombesin_on cck_on endothelin_on ghrelin_on npy_on nts_on orexin_on vasopressin-ot_on tachykinin_on sst_on relaxin_on trh_on nmur_on motilin_on melanocortin_on galanin_on fpr-alx_on compl-peptide_on bradykinin_on apelin_on
3.33	Single	5GLH	Endothelin-1	5GLH-ET_B-Endothelin-1
3.33	Single	6IGK	Endothelin-3	6IGK-ET_B-Endothelin-3
3.33	Single	7TYI	Amylin	7TYI-CT-Amylin-Gs/&β;1/&γ;2
3.33	Consensus	bb2_on	Orthosteric Ligand	7W40-BB₂-Bombesin-chim(NtGi1L-Gq)/&β;1/&γ;2 7W3Z-BB₂-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/&β;1/&γ;2
3.33	Consensus	gi_peptide	Orthosteric Ligand	gi_opioid gi_endothelin gi_formylpeptide gi_galanin gi_ghrelin gi_neuromedin gi_neurotensin gi_relaxin gi_neuropeptide gi_somatostatin gi_apelin gi_compl-peptide gi_cck
3.33	Consensus	gq_bombesin	Orthosteric Ligand	7W40-BB₂-Bombesin-chim(NtGi1L-Gq)/&β;1/&γ;2 7W3Z-BB₂-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/&β;1/&γ;2
3.23	Single	8HBD	IRL1620	8HBD-ET_B-IRL1620-Gi1/&β;1/&γ;2
3.23	Consensus	gi_endothelin	Orthosteric Ligand	8IY5-ET_B-Endothelin-1-Gi1/&β;1/&γ;2 8HBD-ET_B-IRL1620-Gi1/&β;1/&γ;2
3.12	Single	6LRY	Sarafotoxin-B	6LRY-ET_B-Sarafotoxin-B
3.12	Single	8U1U	CCL1	8U1U-CCR8-CCL1-Gi1/&β;1/&γ;2
3.03	Single	7TYY	Calcitonin-1	7TYY-CT (AMY2)-Calcitonin-1-Gs/&β;1/&γ;2; RAMP2
3.03	Consensus	mc2_on	Orthosteric Ligand	8GY7-MC₂-Corticotropin-Ca-chim(NtGi1-Gs)/&β;1/&γ;2; MRAP1
2.94	Consensus	gs_class-b	Orthosteric Ligand	gs_class-b1 gs_class-b2
2.56	Single	8GY7	Corticotropin	8GY7-MC₂-Corticotropin-Ca-chim(NtGi1-Gs)/&β;1/&γ;2; MRAP1
2.50	Single	8F0J	Pramlintide analogue san45	8F0J-CT-Pramlintide analogue san45-Gs/&β;1/&γ;2

PDB Summary
PDB	7Y14
Class	A
SubFamily	Orphan
Type	A orphans
SubType	MRGPRD
Species	Homo sapiens
Ligand	Beta-alanine
Other Ligand(s)	-
Protein Partners	-
PDB Resolution	3.2
Date	2022-07-20
D.O.I.	10.1038/s42003-022-03668-3

Net Summary
I_min	3.52
Number of Linked Nodes	248
Number of Links	270
Number of Hubs	33
Number of Links mediated by Hubs	121
Number of Communities	6
Number of Nodes involved in Communities	40
Number of Links involved in Communities	53

Path Summary
Number Of Nodes in MetaPath	52
Number Of Links MetaPath	51
Number of Shortest Paths	71663
Length Of Smallest Path	3
Average Path Length	19.6372
Length of Longest Path	38
Minimum Path Strength	1.44
Average Path Strength	7.36577
Maximum Path Strength	30.86
Minimum Path Correlation	0.7
Average Path Correlation	0.92243
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	3.84615
Average % Of Corr. Nodes	37.2226
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	38.7094
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process
Gene Ontology	Cellular Component
SCOP2	Domain Identifier
SCOP2	Family Identifier
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	BAL
PDB Residues	L:L:?1
Environment Details	Open EMBL-EBI Page
Code	BAL
Name	beta-Alanine
Synonyms	3-aminopropanoic acid
Identifier	3-azanylpropanoic acid
Formula	C3 H7 N O2
Molecular Weight	89.093
SMILES	C(CN)C(=O)O
PubChem	239
Formal Charge	0
Total Atoms	13
Total Chiral Atoms	0
Total Bonds	12
Total Aromatic Bonds	0


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	Q8TDS7
Sequence	>7Y14_Chain_R T V H T A Y L V L S S L A M F T C L C G M A G N S M V I W L L G F R M H R N P F C I Y I L N L A A A D L L F L F S M A S T L S L E T Q P L V N T T D K V H E L M K R L M Y F A Y T V G L S L L T A I S T Q R C L S V L F P I W F K C H R P R H L S A W V C G L L W T L C L L M N G L T S S F C S K F L K F N E D R C F R V D M V Q A A L I M G V L T P V M T L S S L T L F V W V R R S S Q Q W R R Q P T R L F V V V L A S V L V F L I C S L P L S I Y W F V L Y W L S L P P E M Q V L C F S L S R L S S S V S S S A N P V I Y F L V G S R R S H Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	7Y12	A	Orphan	A orphans	MRGPRD	Homo sapiens	Beta-alanine	-	Gi1/&β;1/&γ;2	3.1	2022-07-20	10.1038/s42003-022-03668-3
	7Y13	A	Orphan	A orphans	MRGPRD	Homo sapiens	-	-	-	3.1	2022-07-20	10.1038/s42003-022-03668-3
	7Y14	A	Orphan	A orphans	MRGPRD	Homo sapiens	Beta-alanine	-	-	3.2	2022-07-20	10.1038/s42003-022-03668-3
	7Y15	A	Orphan	A orphans	MRGPRD	Homo sapiens	-	-	Gi1/&β;1/&γ;2	2.9	2022-07-20	10.1038/s42003-022-03668-3

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