psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:R103	5.67	Yes	Yes	2	0	4
2	L:L:?1	R:R:C164	9.26	Yes	No	2	0	6
3	L:L:?1	R:R:C175	3.7	Yes	No	2	0	8
4	L:L:?1	R:R:D179	11.08	Yes	No	0	0	3
5	L:L:?1	R:R:W241	21.26	Yes	Yes	0	0	4
6	L:L:?1	R:R:Y245	17.78	Yes	No	0	0	4
7	R:R:E252	R:R:V23	7.13	No	No	0	2	1
8	R:R:H24	R:R:L28	3.86	No	No	0	1	4
9	R:R:S31	R:R:Y27	8.9	No	Yes	0	3	3
10	R:R:E86	R:R:Y27	5.61	No	Yes	0	3	3
11	R:R:V255	R:R:Y27	5.05	No	Yes	0	1	3
12	R:R:L30	R:R:S259	7.51	No	No	0	5	3
13	R:R:R262	R:R:S31	5.27	Yes	No	0	4	3
14	R:R:L263	R:R:L33	4.15	No	No	0	5	5
15	R:R:L83	R:R:M35	8.48	No	No	0	6	4
16	R:R:S266	R:R:T37	4.8	No	No	0	6	7
17	R:R:T37	R:R:V267	6.35	No	No	0	7	5
18	R:R:C38	R:R:L76	6.35	No	No	0	6	7
19	R:R:G41	R:R:S270	3.71	No	No	0	9	8
20	R:R:F77	R:R:M42	4.98	No	No	0	4	7
21	R:R:D72	R:R:N45	6.73	Yes	No	0	9	9
22	R:R:F277	R:R:V48	7.87	Yes	No	0	7	9
23	R:R:I49	R:R:L66	4.28	No	No	0	7	8
24	R:R:L51	R:R:W50	4.56	No	No	0	7	6
25	R:R:F277	R:R:L51	4.87	Yes	No	0	7	7
26	R:R:L52	R:R:M56	4.24	Yes	No	0	8	7
27	R:R:H57	R:R:L52	9	Yes	Yes	5	6	8
28	R:R:L52	R:R:L66	5.54	Yes	No	5	8	8
29	R:R:F277	R:R:L52	3.65	Yes	Yes	0	7	8
30	R:R:F54	R:R:R55	12.83	No	No	0	6	6
31	R:R:M56	R:R:R283	6.2	No	Yes	0	7	6
32	R:R:H57	R:R:I63	3.98	Yes	No	0	6	7
33	R:R:H57	R:R:L66	6.43	Yes	No	5	6	8
34	R:R:N59	R:R:P60	6.52	Yes	No	1	8	7
35	R:R:F61	R:R:N59	12.08	Yes	Yes	1	8	8
36	R:R:C62	R:R:N59	4.72	No	Yes	1	8	8
37	R:R:N59	R:R:R283	14.46	Yes	Yes	1	8	6
38	R:R:F133	R:R:P60	5.78	Yes	No	1	7	7
39	R:R:P60	R:R:R137	5.76	No	Yes	1	7	9
40	R:R:F61	R:R:Q122	14.05	Yes	No	1	8	9
41	R:R:F61	R:R:S126	5.28	Yes	No	1	8	8
42	R:R:F133	R:R:F61	7.5	Yes	Yes	1	7	8
43	R:R:C62	R:R:R283	4.18	No	Yes	1	8	6
44	R:R:I63	R:R:S142	7.74	No	No	0	7	9
45	R:R:A118	R:R:Y64	5.34	No	Yes	0	8	8
46	R:R:I119	R:R:Y64	3.63	No	Yes	0	9	8
47	R:R:Q122	R:R:Y64	11.27	No	Yes	0	9	8
48	R:R:S142	R:R:Y64	13.99	No	Yes	0	9	8
49	R:R:V145	R:R:Y64	6.31	No	Yes	0	6	8
50	R:R:C146	R:R:N67	7.87	No	No	0	7	9
51	R:R:D72	R:R:L68	9.5	Yes	No	0	9	9
52	R:R:L115	R:R:L68	4.15	No	No	0	7	9
53	R:R:L116	R:R:L68	5.54	No	No	0	9	9
54	R:R:D72	R:R:S269	8.83	Yes	No	0	9	9
55	R:R:D72	R:R:N272	6.73	Yes	No	0	9	9
56	R:R:A108	R:R:L74	4.73	No	No	0	7	6
57	R:R:F75	R:R:L76	6.09	Yes	No	3	6	7
58	R:R:F75	R:R:M79	3.73	Yes	No	3	6	5
59	R:R:F75	R:R:M105	4.98	Yes	Yes	3	6	4
60	R:R:F75	R:R:Y109	7.22	Yes	Yes	3	6	8
61	R:R:F75	R:R:S265	5.28	Yes	No	3	6	8
62	R:R:F75	R:R:S269	7.93	Yes	No	3	6	9
63	R:R:L76	R:R:S269	4.5	No	No	3	7	9
64	R:R:F77	R:R:M101	3.73	No	No	0	4	4
65	R:R:M105	R:R:S78	4.6	Yes	No	0	4	5
66	R:R:M105	R:R:M79	7.22	Yes	No	3	4	5
67	R:R:M79	R:R:R262	4.96	No	Yes	0	5	4
68	R:R:M101	R:R:S81	9.2	No	No	0	4	5
69	R:R:H98	R:R:T82	4.11	Yes	No	0	5	3
70	R:R:L83	R:R:R262	4.86	No	Yes	0	6	4
71	R:R:H98	R:R:L85	7.71	Yes	No	0	5	3
72	R:R:E86	R:R:H98	3.69	No	Yes	0	3	5
73	R:R:H98	R:R:L90	7.71	Yes	No	0	5	1
74	R:R:D95	R:R:F167	9.55	No	No	0	1	1
75	R:R:F167	R:R:K96	13.65	No	No	0	1	1
76	R:R:H98	R:R:K102	6.55	Yes	No	0	5	3
77	R:R:E99	R:R:R103	11.63	No	Yes	2	5	4
78	R:R:E99	R:R:S165	8.62	No	Yes	2	5	3
79	R:R:E99	R:R:F167	5.83	No	No	0	5	1
80	R:R:K102	R:R:R103	4.95	No	Yes	0	3	4
81	R:R:K102	R:R:Y106	3.58	No	Yes	0	3	3
82	R:R:R103	R:R:S161	9.22	Yes	No	2	4	3
83	R:R:R103	R:R:S165	6.59	Yes	Yes	2	4	3
84	R:R:M105	R:R:Y106	11.97	Yes	Yes	0	4	3
85	R:R:L237	R:R:Y106	4.69	No	Yes	0	5	3
86	R:R:W241	R:R:Y106	40.51	Yes	Yes	0	4	3
87	R:R:F107	R:R:W150	5.01	No	Yes	0	5	9
88	R:R:F107	R:R:L154	6.09	No	No	0	5	4
89	R:R:F107	R:R:N157	12.08	No	No	0	5	7
90	R:R:L113	R:R:Y109	15.24	No	Yes	0	8	8
91	R:R:L237	R:R:Y109	5.86	No	Yes	3	5	8
92	R:R:S238	R:R:Y109	5.09	No	Yes	0	7	8
93	R:R:S265	R:R:Y109	7.63	No	Yes	3	8	8
94	R:R:N157	R:R:T110	4.39	No	No	0	7	6
95	R:R:V111	R:R:W150	15.94	No	Yes	0	7	9
96	R:R:C153	R:R:V111	6.83	No	No	0	8	7
97	R:R:L149	R:R:S114	10.51	No	No	0	7	7
98	R:R:L116	R:R:N272	6.87	No	No	0	9	9
99	R:R:L116	R:R:Y276	4.69	No	Yes	0	9	9
100	R:R:L190	R:R:T117	8.84	No	No	0	8	8
101	R:R:M194	R:R:T117	4.52	No	No	0	8	8
102	R:R:I119	R:R:Y276	7.25	No	Yes	0	9	9
103	R:R:M194	R:R:S120	7.67	No	No	0	8	9
104	R:R:S197	R:R:T121	6.4	No	No	0	8	6
105	R:R:F133	R:R:Q122	4.68	Yes	No	1	7	9
106	R:R:R123	R:R:Y276	7.2	No	Yes	0	9	9
107	R:R:C124	R:R:S197	5.16	No	No	0	8	8
108	R:R:F133	R:R:S126	7.93	Yes	No	1	7	8
109	R:R:L201	R:R:V127	4.47	No	No	0	8	8
110	R:R:F129	R:R:L128	4.87	No	No	0	5	6
111	R:R:L128	R:R:T200	4.42	No	No	0	6	5
112	R:R:L128	R:R:W204	9.11	No	No	0	6	6
113	R:R:H136	R:R:W132	5.29	No	No	0	6	6
114	R:R:R137	R:R:W132	9	Yes	No	0	9	6
115	R:R:F133	R:R:R137	10.69	Yes	Yes	1	7	9
116	R:R:C135	R:R:H136	7.37	No	No	0	7	6
117	R:R:L141	R:R:R137	7.29	No	Yes	1	5	9
118	R:R:L141	R:R:P138	8.21	No	No	1	5	8
119	R:R:P138	R:R:W144	5.4	No	No	1	8	5
120	R:R:H140	R:R:R139	4.51	No	No	0	5	5
121	R:R:L141	R:R:W144	6.83	No	No	1	5	5
122	R:R:L148	R:R:L152	6.92	No	No	0	5	6
123	R:R:M156	R:R:Q182	6.8	No	Yes	0	4	6
124	R:R:N157	R:R:Q182	3.96	No	Yes	0	7	6
125	R:R:F163	R:R:L159	3.65	Yes	No	0	4	6
126	R:R:T160	R:R:V178	4.76	No	No	0	4	4
127	R:R:Q182	R:R:T160	7.09	Yes	No	0	6	4
128	R:R:S161	R:R:S165	4.89	No	Yes	2	3	3
129	R:R:L168	R:R:S161	4.5	No	No	2	1	3
130	R:R:F163	R:R:S162	5.28	Yes	No	0	4	3
131	R:R:F163	R:R:R174	16.03	Yes	No	0	4	1
132	R:R:F163	R:R:V178	5.24	Yes	No	0	4	4
133	R:R:C164	R:R:C175	7.28	No	No	2	6	8
134	R:R:L168	R:R:S165	9.01	No	Yes	2	1	3
135	R:R:F170	R:R:K166	12.41	No	No	0	1	3
136	R:R:K169	R:R:R174	3.71	No	No	0	1	1
137	R:R:E172	R:R:N171	5.26	No	No	0	3	5
138	R:R:N171	R:R:R174	20.49	No	No	0	5	1
139	R:R:D173	R:R:R177	7.15	No	No	0	3	3
140	R:R:C175	R:R:W246	5.22	No	Yes	0	8	4
141	R:R:F176	R:R:M180	12.44	No	No	0	2	3
142	R:R:F176	R:R:W246	22.05	No	Yes	0	2	4
143	R:R:D179	R:R:W246	14.52	No	Yes	0	3	4
144	R:R:F242	R:R:Q182	11.71	Yes	Yes	0	5	6
145	R:R:A183	R:R:F242	4.16	No	Yes	0	5	5
146	R:R:I186	R:R:S238	6.19	No	No	0	7	7
147	R:R:F242	R:R:I186	3.77	Yes	No	0	5	7
148	R:R:G188	R:R:P192	4.06	No	No	0	5	5
149	R:R:P192	R:R:T191	5.25	No	No	0	5	5
150	R:R:L235	R:R:T191	4.42	No	No	0	6	5
151	R:R:F230	R:R:M194	16.17	No	No	0	9	8
152	R:R:S198	R:R:V223	4.85	No	No	0	8	8
153	R:R:F202	R:R:F220	17.15	No	Yes	0	5	5
154	R:R:F202	R:R:V223	3.93	No	No	0	5	8
155	R:R:F202	R:R:L224	8.53	No	No	0	5	5
156	R:R:R207	R:R:V203	3.92	No	No	0	5	5
157	R:R:S208	R:R:W204	4.94	No	No	0	5	6
158	R:R:L219	R:R:V205	11.92	No	No	0	7	6
159	R:R:F220	R:R:V205	3.93	Yes	No	0	5	6
160	R:R:Q210	R:R:R206	22.2	Yes	No	4	5	5
161	R:R:Q215	R:R:R206	7.01	Yes	No	4	5	5
162	R:R:F220	R:R:R206	6.41	Yes	No	4	5	5
163	R:R:R213	R:R:S209	10.54	No	No	4	5	7
164	R:R:P216	R:R:S209	3.56	No	No	4	7	7
165	R:R:Q210	R:R:Q215	20.48	Yes	Yes	4	5	5
166	R:R:P216	R:R:Q210	7.9	No	Yes	4	7	5
167	R:R:F220	R:R:Q210	15.23	Yes	Yes	4	5	5
168	R:R:Q211	R:R:W212	9.86	No	No	0	5	3
169	R:R:P216	R:R:R213	8.65	No	No	4	7	5
170	R:R:F220	R:R:Q215	4.68	Yes	Yes	4	5	5
171	R:R:R218	R:R:V279	3.92	No	No	0	7	7
172	R:R:V222	R:R:V279	8.02	No	No	0	7	7
173	R:R:I232	R:R:L228	4.28	No	No	0	5	6
174	R:R:F230	R:R:L231	3.65	No	No	0	9	8
175	R:R:F230	R:R:L235	3.65	No	No	0	9	6
176	R:R:S234	R:R:S268	6.52	No	No	0	7	9
177	R:R:P236	R:R:S261	3.56	No	No	0	9	5
178	R:R:P236	R:R:S264	5.34	No	No	0	9	7
179	R:R:L237	R:R:S265	6.01	No	No	3	5	8
180	R:R:W241	R:R:Y240	3.86	Yes	Yes	0	4	3
181	R:R:Q254	R:R:Y240	6.76	No	Yes	0	2	3
182	R:R:F258	R:R:Y240	14.44	No	Yes	0	3	3
183	R:R:S261	R:R:Y240	3.82	No	Yes	0	5	3
184	R:R:F242	R:R:W241	8.02	Yes	Yes	0	5	4
185	R:R:W246	R:R:Y245	13.5	Yes	No	0	4	4
186	R:R:L249	R:R:M253	5.65	No	No	0	3	1
187	R:R:F258	R:R:R262	16.03	No	Yes	0	3	4
188	R:R:R262	R:R:S259	3.95	Yes	No	0	4	3
189	R:R:N272	R:R:S268	4.47	No	No	0	9	9
190	R:R:I275	R:R:Y276	3.63	No	Yes	0	8	9
191	R:R:F277	R:R:L278	3.65	Yes	No	0	7	7
192	R:R:S281	R:R:S284	4.89	No	No	0	7	5
193	R:R:H285	R:R:S281	9.76	No	No	0	4	7
194	R:R:R282	R:R:R283	5.33	No	Yes	0	5	6
195	R:R:L28	R:R:Y27	3.52	No	Yes	0	4	3
196	R:R:L244	R:R:Y240	3.52	No	Yes	0	3	3
197	R:R:C38	R:R:S266	3.44	No	No	0	6	6
198	R:R:C233	R:R:S268	3.44	No	No	0	7	9
199	R:R:C233	R:R:V229	3.42	No	No	0	7	7
200	R:R:A69	R:R:V48	3.39	No	No	0	9	9
201	R:R:N67	R:R:W150	3.39	No	Yes	0	9	9
202	R:R:C124	R:R:T200	3.38	No	No	0	8	5
203	R:R:M253	R:R:P250	3.35	No	No	0	1	1
204	R:R:N45	R:R:P273	3.26	No	No	0	9	9
205	R:R:C257	R:R:M253	3.24	No	No	0	4	1
206	R:R:S32	R:R:V29	3.23	No	No	0	5	4
207	R:R:S114	R:R:V111	3.23	No	No	0	7	7
208	R:R:S126	R:R:V127	3.23	No	No	0	8	8
209	R:R:S198	R:R:V227	3.23	No	No	0	8	8
210	R:R:S226	R:R:V227	3.23	No	No	0	7	8
211	R:R:A80	R:R:M35	3.22	No	No	0	6	4
212	R:R:S270	R:R:T37	3.2	No	No	0	8	7
213	R:R:T22	R:R:V23	3.17	No	No	0	1	1
214	R:R:T117	R:R:V193	3.17	No	No	0	8	6
215	R:R:H140	R:R:W144	3.17	No	No	0	5	5
216	R:R:P89	R:R:Q88	3.16	No	No	0	3	4
217	R:R:M101	R:R:V97	3.04	No	No	0	4	5
218	R:R:M156	R:R:V181	3.04	No	No	0	4	3
219	R:R:L73	R:R:S46	3	No	No	0	7	6
220	R:R:L74	R:R:S78	3	No	No	0	6	5
221	R:R:L256	R:R:V23	2.98	No	No	0	2	1
222	R:R:L190	R:R:V189	2.98	No	No	0	8	5
223	R:R:L201	R:R:V223	2.98	No	No	0	8	8
224	R:R:L231	R:R:V227	2.98	No	No	0	8	8
225	R:R:L85	R:R:T94	2.95	No	No	0	3	1
226	R:R:L90	R:R:T94	2.95	No	No	0	1	1
227	R:R:L125	R:R:T121	2.95	No	No	0	6	6
228	R:R:A143	R:R:H140	2.93	No	No	0	5	5
229	R:R:N92	R:R:T93	2.92	No	No	0	5	2
230	R:R:I49	R:R:L73	2.85	No	No	0	7	7
231	R:R:L73	R:R:M42	2.83	No	No	0	7	7
232	R:R:C40	R:R:F36	2.79	No	No	0	6	5
233	R:R:L260	R:R:L30	2.77	No	No	0	4	5
234	R:R:A71	R:R:W150	2.59	No	Yes	0	9	9
235	R:R:E172	R:R:F170	2.33	No	No	0	3	1
236	R:R:C146	R:R:G147	1.96	No	No	0	7	5
237	R:R:A43	R:R:G44	1.95	No	No	0	5	9
238	R:R:A71	R:R:G112	1.95	No	No	0	9	9
239	R:R:P250	R:R:P251	1.95	No	No	0	1	2
240	R:R:P89	R:R:V91	1.77	No	No	0	3	4
241	R:R:C40	R:R:S270	1.72	No	No	0	6	8
242	R:R:A183	R:R:V243	1.7	No	No	0	5	5
243	R:R:I131	R:R:P130	1.69	No	No	0	7	9
244	R:R:C135	R:R:I131	1.64	No	No	0	7	7
245	R:R:C233	R:R:I232	1.64	No	No	0	7	5
246	R:R:S197	R:R:V193	1.62	No	No	0	8	6
247	R:R:A225	R:R:I275	1.62	No	No	0	6	8
248	R:R:V221	R:R:V222	1.6	No	No	0	6	7
249	R:R:G53	R:R:H57	1.59	No	Yes	0	6	6
250	R:R:A26	R:R:L30	1.58	No	No	0	3	5
251	R:R:A34	R:R:L83	1.58	No	No	0	6	6
252	R:R:A34	R:R:L263	1.58	No	No	0	6	5
253	R:R:I65	R:R:V48	1.54	No	No	0	8	9
254	R:R:M35	R:R:S84	1.53	No	No	0	4	5
255	R:R:M56	R:R:S284	1.53	No	No	0	7	5
256	R:R:L33	R:R:S32	1.5	No	No	0	5	5
257	R:R:L104	R:R:S78	1.5	No	No	0	5	5
258	R:R:N92	R:R:V91	1.48	No	No	0	5	4
259	R:R:L196	R:R:T195	1.47	No	No	0	4	4
260	R:R:L231	R:R:T195	1.47	No	No	0	8	4
261	R:R:I186	R:R:L185	1.43	No	No	0	7	5
262	R:R:I239	R:R:L235	1.43	No	No	0	6	6
263	R:R:Q215	R:R:T217	1.42	Yes	No	0	5	5
264	R:R:L100	R:R:L104	1.38	No	No	0	4	5
265	R:R:L247	R:R:L249	1.38	No	No	0	3	3
266	R:R:C257	R:R:Y240	1.34	No	Yes	0	4	3
267	R:R:R283	R:R:R58	1.07	Yes	No	0	6	7
268	R:R:F176	R:R:R177	1.07	No	No	0	2	3

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	L:L:?1	11.4583	6	2	0
2	R:R:Y27	5.77	4	0	3
3	R:R:L52	5.6075	4	5	8
4	R:R:H57	5.25	4	5	6
5	R:R:N59	9.445	4	1	8
6	R:R:F61	9.7275	4	1	8
7	R:R:Y64	8.108	5	0	8
8	R:R:D72	7.9475	4	0	9
9	R:R:F75	5.87167	6	3	6
10	R:R:H98	5.954	5	0	5
11	R:R:R103	7.612	5	2	4
12	R:R:M105	7.1925	4	3	4
13	R:R:Y106	15.1875	4	0	3
14	R:R:Y109	8.208	5	3	8
15	R:R:F133	7.316	5	1	7
16	R:R:R137	8.185	4	1	9
17	R:R:W150	6.7325	4	0	9
18	R:R:F163	7.55	4	0	4
19	R:R:S165	7.2775	4	2	3
20	R:R:Q182	7.39	4	0	6
21	R:R:Q210	16.4525	4	4	5
22	R:R:Q215	8.3975	4	4	5
23	R:R:F220	9.48	5	4	5
24	R:R:Y240	5.62333	6	0	3
25	R:R:W241	18.4125	4	0	4
26	R:R:F242	6.915	4	0	5
27	R:R:W246	13.8225	4	0	4
28	R:R:R262	7.014	5	0	4
29	R:R:Y276	5.6925	4	0	9
30	R:R:F277	5.01	4	0	7
31	R:R:R283	6.248	5	1	6

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:W241	16.1317	21.26	Yes	Yes	0	0	4
2	R:R:W241	R:R:Y240	11.2258	3.86	Yes	Yes	0	4	3
3	R:R:F258	R:R:R262	10.3708	16.03	No	Yes	0	3	4
4	R:R:W241	R:R:Y106	40.9418	40.51	Yes	Yes	0	4	3
5	R:R:M105	R:R:Y106	50.7245	11.97	Yes	Yes	0	4	3
6	R:R:F75	R:R:M105	53.0012	4.98	Yes	Yes	3	6	4
7	R:R:F75	R:R:S269	94.4338	7.93	Yes	No	3	6	9
8	R:R:D72	R:R:S269	100	8.83	Yes	No	0	9	9
9	R:R:D72	R:R:L68	49.5248	9.5	Yes	No	0	9	9
10	R:R:L116	R:R:L68	49.4079	5.54	No	No	0	9	9
11	R:R:L116	R:R:Y276	99.7936	4.69	No	Yes	0	9	9
12	R:R:I119	R:R:Y276	98.2258	7.25	No	Yes	0	9	9
13	R:R:I119	R:R:Y64	97.7934	3.63	No	Yes	0	9	8
14	R:R:S142	R:R:Y64	18.5759	13.99	No	Yes	0	9	8
15	R:R:I63	R:R:S142	17.8066	7.74	No	No	0	7	9
16	R:R:H57	R:R:I63	16.9439	3.98	Yes	No	0	6	7
17	R:R:D72	R:R:N272	51.2698	6.73	Yes	No	0	9	9
18	R:R:L116	R:R:N272	50.8608	6.87	No	No	0	9	9
19	R:R:Q122	R:R:Y64	79.5758	11.27	No	Yes	0	9	8
20	R:R:F61	R:R:Q122	38.186	14.05	Yes	No	1	8	9
21	R:R:F133	R:R:Q122	40.8639	4.68	Yes	No	1	7	9
22	R:R:F61	R:R:S126	33.3736	5.28	Yes	No	1	8	8
23	R:R:F133	R:R:S126	32.1232	7.93	Yes	No	1	7	8
24	R:R:F242	R:R:W241	24.0155	8.02	Yes	Yes	0	5	4
25	R:R:F242	R:R:Q182	38.7197	11.71	Yes	Yes	0	5	6
26	R:R:N157	R:R:Q182	19.7815	3.96	No	Yes	0	7	6
27	R:R:F107	R:R:N157	17.1445	12.08	No	No	0	5	7
28	R:R:F107	R:R:W150	14.3205	5.01	No	Yes	0	5	9
29	R:R:F242	R:R:I186	19.4543	3.77	Yes	No	0	5	7
30	R:R:I186	R:R:S238	20.3911	6.19	No	No	0	7	7
31	R:R:S126	R:R:V127	64.0498	3.23	No	No	0	8	8
32	R:R:L201	R:R:V127	62.5852	4.47	No	No	0	8	8
33	R:R:L201	R:R:V223	61.3095	2.98	No	No	0	8	8
34	R:R:S198	R:R:V223	42.3188	4.85	No	No	0	8	8
35	R:R:S198	R:R:V227	40.8055	3.23	No	No	0	8	8
36	R:R:L231	R:R:V227	37.7615	2.98	No	No	0	8	8
37	R:R:F230	R:R:L231	33.1632	3.65	No	No	0	9	8
38	R:R:F230	R:R:M194	23.8616	16.17	No	No	0	9	8
39	R:R:M194	R:R:T117	20.7299	4.52	No	No	0	8	8
40	R:R:T117	R:R:V193	16.0032	3.17	No	No	0	8	6
41	R:R:S197	R:R:V193	14.4198	1.62	No	No	0	8	6
42	R:R:Q182	R:R:T160	15.6156	7.09	Yes	No	0	6	4
43	R:R:T160	R:R:V178	14.3517	4.76	No	No	0	4	4
44	R:R:F163	R:R:V178	12.9338	5.24	Yes	No	0	4	4
45	R:R:F202	R:R:V223	18.9635	3.93	No	No	0	5	8
46	R:R:F202	R:R:F220	15.8045	17.15	No	Yes	0	5	5
47	R:R:M79	R:R:R262	20.728	4.96	No	Yes	0	5	4
48	R:R:K102	R:R:Y106	11.5744	3.58	No	Yes	0	3	3
49	R:R:S238	R:R:Y109	20.9481	5.09	No	Yes	0	7	8
50	R:R:F75	R:R:M79	20.7455	3.73	Yes	No	3	6	5
51	R:R:F75	R:R:Y109	22.6736	7.22	Yes	Yes	3	6	8

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:?1	R:R:R103	5.67	2	Yes	Yes	0	4	0	1
L:L:?1	R:R:C164	9.26	2	Yes	No	0	6	0	1
L:L:?1	R:R:C175	3.7	2	Yes	No	0	8	0	1
L:L:?1	R:R:D179	11.08	2	Yes	No	0	3	0	1
L:L:?1	R:R:W241	21.26	2	Yes	Yes	0	4	0	1
L:L:?1	R:R:Y245	17.78	2	Yes	No	0	4	0	1
R:R:E99	R:R:R103	11.63	2	No	Yes	5	4	2	1
R:R:E99	R:R:S165	8.62	2	No	Yes	5	3	2	2
R:R:K102	R:R:R103	4.95	0	No	Yes	3	4	2	1
R:R:K102	R:R:Y106	3.58	0	No	Yes	3	3	2	2
R:R:R103	R:R:S161	9.22	2	Yes	No	4	3	1	2
R:R:R103	R:R:S165	6.59	2	Yes	Yes	4	3	1	2
R:R:W241	R:R:Y106	40.51	0	Yes	Yes	4	3	1	2
R:R:S161	R:R:S165	4.89	2	No	Yes	3	3	2	2
R:R:C164	R:R:C175	7.28	2	No	No	6	8	1	1
R:R:C175	R:R:W246	5.22	2	No	Yes	8	4	1	2
R:R:D179	R:R:W246	14.52	0	No	Yes	3	4	1	2
R:R:W241	R:R:Y240	3.86	0	Yes	Yes	4	3	1	2
R:R:F242	R:R:W241	8.02	0	Yes	Yes	5	4	2	1
R:R:W246	R:R:Y245	13.5	0	Yes	No	4	4	2	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

Similarity	Network Type	Name	Ligand	Description
85.71	Single	7Y12	Beta-Alanine	7Y12-MRGPRD-β-Alanine-Gi1/β1/γ2
50.00	Single	9DQH	EP-2825	9DQH-MRGPRD-EP-2825-chim(NtGi1-Gs-CtGq)/β1/γ2
33.33	Single	7VDM	Substance-P	7VDM-MRGPRX2-Substance-P-Gi1/β1/γ2
28.57	Single	9DQJ	EP-3945	9DQJ-MRGPRD-EP-3945-chim(NtGi1-Gs-CtGq)/β1/γ2
25.00	Single	8JGB	Conorfamide-Tx2	8JGB-MRGPRX1-Conorfamide-Tx2-Gi1/β1/γ2
23.08	Single	8HJ5	PubChem 139030531	8HJ5-MRGPRX1-PubChem 139030531-chim(NtGi1-Gs-CtGq)/β1/γ2
21.05	Single	8DWG	Proenkephalin-A	8DWG-MRGPRX1-Proenkephalin-A-ML382-chim(NtGi2L-Gs-CtGq)/β1/γ2
20.00	Single	7VV0	PAMP-12	7VV0-MRGPRX2-PAMP-12
18.75	Single	8JGF	BAM8-22	8JGF-MRGPRX1-BAM8-22-chim(NtGi1-Gs-CtGq)/β1/γ2
17.65	Single	8DWC	Proenkephalin-A	8DWC-MRGPRX1-Proenkephalin-A-chim(NtGi2L-Gs-CtGq)/β1/γ2
16.67	Single	7S8N	R-Zinc-3573	7S8N-MRGPRX2-R-Zinc-3573-chim(NtGi2L-Gs-CtGq)/β1/γ2
16.67	Single	7S8O	R-Zinc-3573	7S8O-MRGPRX2-R-Zinc-3573-Gi1/β1/γ2
16.67	Single	7VDH	C48/80	7VDH-MRGPRX2-C48/80-Gi1/β1/γ2
16.67	Single	7XP6	Strychnine	7XP6-T2R46-Strychnine-chim(Gs-CtGt3)/β1/γ2
15.38	Single	7VDL	Cortistatin-14	7VDL-MRGPRX2-Cortistatin-14-Gi1/β1/γ2
15.38	Single	7VV5	C48/80	7VV5-MRGPRX2-C48/80-Gi1/β1/γ2
15.38	Single	8DWH	PubChem 139030531	8DWH-MRGPRX1-PubChem 139030531-chim(NtGi2L-Gs-CtGq)/β1/γ2
15.38	Single	8T3S	Butyric acid	8T3S-FFA2-Butyric acid-chim(NtGi2L-Gs-CtGq)/β1/γ2
15.00	Single	8IZB	Lysophosphatidylserine	8IZB-GPR174-Lysophosphatidylserine-Gs/β1/γ2
14.29	Single	7UTZ	PubChem 644078	7UTZ-TSH-TR1402-PubChem 644078-Gs/β1/γ2
14.29	Single	7VV6	C48/80	7VV6-MRGPRX2-C48/80
14.29	Single	8K4N	VF0	8K4N-GPR34-VF0-Gi1/β1/γ2
13.33	Single	7PP1	Selatogrel	7PP1-P2Y₁₂-Selatogrel
13.33	Single	8XBG	S3E-LysoPS	8XBG-GPR34-S3E-LysoPS
13.33	Single	9IYA	ONO-9710531	9IYA-GPR55-ONO-9710531
12.50	Single	4NTJ	AZD1283	4NTJ-P2Y₁₂-AZD1283
12.50	Single	5ZBQ	UR-MK-299	5ZBQ-Y₁-UR-MK-299
12.50	Single	6HLP	Netupitant	6HLP-NK₁-Netupitant
12.50	Single	6RZ4	Pranlukast	6RZ4-CysLT₁-Pranlukast-Na
12.50	Single	7E9G	JNJ-40411813	7E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/β1/γ2
12.50	Single	7XV3	Lysophosphatidylserine	7XV3-GPR174-Lysophosphatidylserine-chim(NtGi1-Gs)/β1/γ2
12.50	Single	8IZ4	Lysophosphatidylserine	8IZ4-GPR34-Lysophosphatidylserine-Gi1/β1/γ2
12.50	Single	8JGG	BAM8-22	8JGG-MRGPRX1-BAM8-22-Gi1/β1/γ2
12.50	Consensus	cyslt_off	Orthosteric Ligand	cyslt2_off cyslt1_off
11.76	Single	5ZBH	BMS-193885	5ZBH-Y₁-BMS-193885
11.76	Single	6KO5	PubChem 57400002	6KO5-Ghrelin-PubChem 57400002
11.76	Single	7F58	THIQ	7F58-MC₄-THIQ-Gs/β1/γ2
11.76	Single	7R0C	AVP	7R0C-V₂-AVP-Arrestin2
11.76	Single	7S8M	Cortistatin-14	7S8M-MRGPRX2-Cortistatin-14-Gi1/β1/γ2
11.76	Single	7Y24	Octreotide	7Y24-SST2-Octreotide-Go/β1/γ2
11.76	Single	8I2G	Compound 716340	8I2G-FSH-Glycoprotein hormones α chain-Compound 716340-Gs/β1/γ2
11.76	Single	8JSR	Anamorelin	8JSR-Ghrelin-Anamorelin-chim(NtGi1-Gs-CtGq)/β1/γ2
11.76	Single	8XBI	S3E-LysoPS	8XBI-GPR34-S3E-LysoPS
11.76	Single	9GE2	ML184	9GE2-GPR55-ML184-Cholesterol-chim(CtGi1-G13)/β1/γ2
11.76	Consensus	ffa_on	Orthosteric Ligand	ffa2_on ffa3_on
11.76	Consensus	ffa_on_gp	Orthosteric Ligand	ffa2_on_gp ffa3_on_gp
11.76	Consensus	gi_ffa	Orthosteric Ligand	8J21-FFA3-Butyric acid-Gi1/β1/γ2 8J22-FFA2-TUG-1375-Gi1/β1/γ2
11.76	Consensus	npy1_off	Orthosteric Ligand	5ZBH-Y₁-BMS-193885 5ZBQ-Y₁-UR-MK-299
11.76	Consensus	npy_off	Orthosteric Ligand	npy1_off npy2_off
11.76	Consensus	p2y12_on	Orthosteric Ligand	7XXI-P2Y₁₂-2MeSADP-Gi2/β1/γ2
11.11	Single	3VW7	Vorapaxar; Na	3VW7-PAR1-Vorapaxar; Na
11.11	Single	4PXZ	2MeSADP	4PXZ-P2Y₁₂-2MeSADP
11.11	Single	5MZP	Caffeine	5MZP-A_2A-Caffeine-Na
11.11	Single	6RZ7	ONO-2570366	6RZ7-CysLT₂-ONO-2570366
11.11	Single	7EXD	Lasmiditan	7EXD-5-HT_1F-Lasmiditan-Gi1/β1/γ2
11.11	Single	7F55	Bremelanotide	7F55-MC₄-Bremelanotide-Gs/β1/γ2
11.11	Single	7XW5	ML109	7XW5-TSH-TSH-ML109-Gs/β1/γ2
11.11	Single	7XW6	ML109	7XW6-TSH-M22 Fab-ML109-Gs/β1/γ2
11.11	Single	7XW9	TRH	7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/β1/γ2
11.11	Single	7XXI	2MeSADP	7XXI-P2Y₁₂-2MeSADP-Gi2/β1/γ2
11.11	Single	8ID9	Eicosapentaenoic acid	8ID9-FFA4-Eicosapentaenoic acid-Gi1/β1/γ2
11.11	Single	8KGG	LPS	8KGG-P2Y10-LPS-chim(NtGi2-G13)/β1/γ2
11.11	Single	8WRB	Lysophosphatidylserine	8WRB-GPR34-Lysophosphatidylserine-Gi1/β1/γ2
11.11	Consensus	5ht1f_on	Orthosteric Ligand	7EXD-5-HT_1F-Lasmiditan-Gi1/β1/γ2
11.11	Consensus	5ht1f_on_gp	Orthosteric Ligand	7EXD-5-HT_1F-Lasmiditan-Gi1/β1/γ2
11.11	Consensus	gi_p2y	Orthosteric Ligand	7XXI-P2Y₁₂-2MeSADP-Gi2/β1/γ2
11.11	Consensus	p2y12_on_gp	Orthosteric Ligand	7XXI-P2Y₁₂-2MeSADP-Gi2/β1/γ2
11.11	Consensus	trh_on	Orthosteric Ligand	7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/β1/γ2
11.11	Consensus	trh_on_gp	Orthosteric Ligand	7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/β1/γ2
10.53	Single	5TUD	Ergotamine	5TUD-5-HT_2B-Ergotamine
10.53	Single	6RZ9	ONO-2770372	6RZ9-CysLT₂-ONO-2770372
10.53	Single	8XBE	S3E-LysoPS	8XBE-GPR34-S3E-LysoPS-Gi1/β1/γ1
10.53	Single	8ZX4	Lysophosphatidylinositol	8ZX4-GPR55-Lysophosphatidylinositol-chim(NtGi1-G13)/β1/γ2
10.53	Consensus	cyslt2_off	Orthosteric Ligand	6RZ7-CysLT₂-ONO-2570366 6RZ8-CysLT₂-ONO-2080365 6RZ9-CysLT₂-ONO-2770372
10.00	Single	5MZJ	Theophylline	5MZJ-A_2A-Theophylline-Na
10.00	Single	6RZ6	ONO-2570366	6RZ6-CysLT₂-ONO-2570366
10.00	Single	7F9Z	GHRP-6	7F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/β1/γ2
10.00	Single	7S8L	Cortistatin-14	7S8L-MRGPRX2-Cortistatin-14-chim(NtGi2L-Gs-CtGq)/β1/γ2
10.00	Single	8H4I	Doconexent	8H4I-FFA4-Doconexent-chim(NtGi1-Gs)/β1/γ2
10.00	Single	8J22	TUG-1375	8J22-FFA2-TUG-1375-Gi1/β1/γ2
10.00	Single	8PWN	Theophylline	8PWN-A_2A-Theophylline
10.00	Single	8SAI	1-Oleoyl-2-Hydroxy-Sn-Glycero-3-Phospho-L-Serine	8SAI-GPR34-1-Oleoyl-2-Hydroxy-Sn-Glycero-3-Phospho-L-Serine-Gi1/β1/γ2
10.00	Single	9GE2	Cholesterol	9GE2-GPR55-ML184-Cholesterol-chim(CtGi1-G13)/β1/γ2
9.52	Single	6RZ8	ONO-2080365	6RZ8-CysLT₂-ONO-2080365
9.52	Single	7F54	Afamelanotide	7F54-MC₄-Afamelanotide-Gs/β1/γ2
9.52	Single	7XAU	Octreotide	7XAU-SST2-Octreotide-Gi1/β1/γ2
9.52	Single	8G59	TUG-891	8G59-FFA4-TUG-891-chim(Gi1-CtGq)/β1/γ2
9.52	Single	8WKY	PG-934	8WKY-MC₄-PG-934
9.52	Single	8WZ2	Orexigenic Neuropeptide QRFP	8WZ2-QRFP-Orexigenic Neuropeptide QRFP-chim(NtGi1L-Gs-CtGq)/β1/γ2
9.52	Single	8XBH	S3E-LysoPS	8XBH-GPR34-S3E-LysoPS-Gi1/β1/γ2
9.52	Single	8ZCJ	Pasireotide	8ZCJ-SST5-Pasireotide-Gi1/β1/γ1
9.52	Consensus	gi_nucleotide	Orthosteric Ligand	gi_adenosine gi_p2y
9.52	Consensus	mc4_on	Orthosteric Ligand	7AUE-MC₄-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2 7F58-MC₄-THIQ-Gs/β1/γ2 7F54-MC₄-Afamelanotide-Gs/β1/γ2 7F53-MC₄-α-MSH-Gs/β1/γ2 7F55-MC₄-Bremelanotide-Gs/β1/γ2
9.09	Single	3RFM	Caffeine	3RFM-A_2A-Caffeine
9.09	Single	6OT0	25(S)-Epoxycholesterol	6OT0-SMO-25(S)-Epoxycholesterol-Gi1/β1/γ2
9.09	Single	6OY9	All-trans-Retinal	6OY9-Rhodopsin-All-trans-Retinal-Gt/β1/γ1
9.09	Single	7DD5	Ca; Ca; Tryptophan; NPS-2143	7DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
9.09	Single	7PIV	Setmelanotide	7PIV-MC₄-Setmelanotide-Gs/β1/γ2
9.09	Single	7XMS	Somatostatin-14	7XMS-SST4-Somatostatin-14-Gi1/β1/γ2
9.09	Single	8A2O	Theophylline	8A2O-A_2A-Theophylline-Na
9.09	Single	8IKG	Q2B	8IKG-CB₁-Q2B-Gi1/β1/γ1
9.09	Single	8IOC	Gamma-MSH	8IOC-MC₃-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
9.09	Single	8K6O	Pro-neuropeptide-Y	8K6O-Y₁-Pro-neuropeptide-Y-Gi2/β1/γ1
9.09	Single	8KH5	Lysophosphatidylserine	8KH5-GPR174-Lysophosphatidylserine-Gs/β1/γ2
9.09	Single	9C2F	Ca; Ca; Tryptophan; '6218; PO4	9C2F-CaS-Ca-Ca; Ca; Tryptophan; '6218; PO4
9.09	Consensus	ghrelin_on	Orthosteric Ligand	7NA7-Ghrelin-Ghrelin-27-Gi1/β1/γ2 7F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/β1/γ2 7NA8-Ghrelin-PubChem 178024-Gi1/β1/γ2
9.09	Consensus	ghrelin_on_gp	Orthosteric Ligand	7NA7-Ghrelin-Ghrelin-27-Gi1/β1/γ2 7F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/β1/γ2 7NA8-Ghrelin-PubChem 178024-Gi1/β1/γ2
9.09	Consensus	mc4_on_gp	Orthosteric Ligand	7AUE-MC₄-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2 7F58-MC₄-THIQ-Gs/β1/γ2 7F54-MC₄-Afamelanotide-Gs/β1/γ2 7F53-MC₄-α-MSH-Gs/β1/γ2 7F55-MC₄-Bremelanotide-Gs/β1/γ2
8.70	Single	6W25	SHU9119	6W25-MC₄-SHU9119-Ca
8.70	Single	7RYC	Oxytocin	7RYC-OT-Oxytocin-chim(NtGi2L-Gs-CtGq)/β1/γ2
8.70	Single	7XOU	Cholecystokinin-8	7XOU-CCK_A-Cholecystokinin-8-Gs/β1/γ2
8.70	Single	8K6M	Neuropeptide-Y	8K6M-Y₁-Neuropeptide-Y-Gi2/β1/γ1
8.70	Single	8K6N	Pro-neuropeptide-Y	8K6N-Y₂-Pro-neuropeptide-Y-Gi2/β1/γ1
8.70	Single	8WKZ	SBL-MC-31	8WKZ-MC₄-SBL-MC-31
8.70	Single	9K27	PrRP31	9K27-PrRP-PrRP31-chim(NtGi1-Gq)/β1/γ2
8.70	Consensus	mc3_on	Orthosteric Ligand	8IOC-MC₃-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
8.70	Consensus	mc3_on_gp	Orthosteric Ligand	8IOC-MC₃-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
8.70	Consensus	npy1_on	Orthosteric Ligand	8K6M-Y₁-Neuropeptide-Y-Gi2/β1/γ1
8.70	Consensus	npy1_on_gp	Orthosteric Ligand	8K6M-Y₁-Neuropeptide-Y-Gi2/β1/γ1
8.33	Single	3UZA	GTPL9236	3UZA-A_2A-GTPL9236
8.33	Single	6FK9	PubChem 132473036	6FK9-Rhodopsin-PubChem 132473036
8.33	Single	7DD7	Ca; Ca; Tryptophan; Evocalcet	7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
8.33	Single	7KH0	AVP	7KH0-V₂-AVP-chim(NtGi1-Gs)/β1/γ2
8.33	Single	7V6A	-	7V6A-M₄-PubChem 9864275-Gi1/β1/γ2
8.33	Single	7WC5	Psilocin	7WC5-5-HT_2A-Psilocin
8.33	Single	8F76	Propanoic acid	8F76-OR51E2-Propanoic acid-Gs/β1/γ2
8.33	Single	8GH1	Constrained Epinephrine	8GH1-β₂-Constrained Epinephrine
8.33	Single	8J21	Butyric acid	8J21-FFA3-Butyric acid-Gi1/β1/γ2
8.33	Single	8J24	Acetic acid	8J24-FFA2-Acetic acid-Gi1/β1/γ2
8.33	Single	8J6Q	Compound 9n	8J6Q-HCA₂-β-Hydroxybutyrate-Compound 9n-Gi1/β1/γ2
8.33	Single	8SZF	Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW	8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
8.33	Single	8XZJ	WN353	8XZJ-Apelin-WN353-Gi1/β1/γ2
8.33	Single	9C1P	Ca; Tryptophan; '6218; PO4	9C1P-CaS-Ca-Ca; Tryptophan; '6218; PO4
8.33	Single	9C1P	Ca; Tryptophan; '6218; PO4	9C1P-CaS-Ca-Ca; Tryptophan; '6218; PO4
8.33	Consensus	5ht2_on	Orthosteric Ligand	5ht2b_on
8.33	Consensus	5ht2b_on	Orthosteric Ligand	7SRR-5-HT_2B-LSD-chim(NtGi2L-Gs-CtGq)/β1/γ2
8.33	Consensus	ffa3_on	Orthosteric Ligand	8J21-FFA3-Butyric acid-Gi1/β1/γ2
8.33	Consensus	ffa3_on_gp	Orthosteric Ligand	8J21-FFA3-Butyric acid-Gi1/β1/γ2
8.33	Consensus	p2y_on_gp	Orthosteric Ligand	p2y1_on_gp p2y10_on_gp p2y12_on_gp
8.00	Single	7X9B	Neuropeptide-Y	7X9B-Y₂-Neuropeptide-Y-Gi1/β1/γ2
8.00	Single	7X9C	Pancreatic Hormone	7X9C-Y₄-Pancreatic Hormone-Gi1/β1/γ2
8.00	Single	8HCQ	Endothelin-1	8HCQ-ET_A-Endothelin-1-chim(NtGi1-Gs-CtGq)/β1/γ2
8.00	Single	8IOD	PG-901	8IOD-MC₅-PG-901-Ca-chim(NtGi1-Gs)/β1/γ2
8.00	Single	8ZPS	PrRP20	8ZPS-PrRP-PrRP20-chim(NtGi1-Gs-CtGq)/β1/γ2
8.00	Consensus	eta_on	Orthosteric Ligand	8HCQ-ET_A-Endothelin-1-chim(NtGi1-Gs-CtGq)/β1/γ2
8.00	Consensus	eta_on_gp	Orthosteric Ligand	8HCQ-ET_A-Endothelin-1-chim(NtGi1-Gs-CtGq)/β1/γ2
7.69	Single	3PBL	Eticlopride	3PBL-D₃-Eticlopride
7.69	Single	3VGA	ZM-241385	3VGA-A_2A-ZM-241385-Antibody
7.69	Single	6FK6	PubChem 132473033	6FK6-Rhodopsin-PubChem 132473033
7.69	Single	6HLL	CP99994	6HLL-NK₁-CP99994
7.69	Single	6PGS	Geraniol	6PGS-Rhodopsin-Geraniol-Gt(CT)
7.69	Single	6PH7	Nerol	6PH7-Rhodopsin-Nerol-Gt(CT)
7.69	Single	6QNO	All-trans-Retinal	6QNO-Rhodopsin-All-trans-Retinal-Gi1/β1/γ1
7.69	Single	6TP4	ACT-462206	6TP4-OX₁-ACT-462206
7.69	Single	6TQ4	PubChem 16046844	6TQ4-OX₁-PubChem 16046844-Na
7.69	Single	7DD5	Ca; Ca; Tryptophan; NPS-2143	7DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
7.69	Single	7DD7	Ca; Ca; Tryptophan; Evocalcet	7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
7.69	Single	7E2Y	Serotonin	7E2Y-5-HT_1A-Serotonin-Gi1/β1/γ2
7.69	Single	7SRQ	LSD	7SRQ-5-HT_2B-LSD
7.69	Single	7VUI	JNJ-63533054	7VUI-GPR139-JNJ-63533054-GTP-chim(Gs-CtGq)/β1/γ2
7.69	Single	7XT9	Serotonin	7XT9-5-HT₄-Serotonin-Gs/β1/γ2
7.69	Single	7XTA	Serotonin	7XTA-5-HT₄-Serotonin-Gi1/β1/γ2
7.69	Single	7XTB	Serotonin	7XTB-5-HT₆-Serotonin-Gs/β1/γ2
7.69	Single	7YS6	Serotonin	7YS6-5-HT₆-Serotonin-chim(NtGi1-Gs)/β1/γ2
7.69	Single	8A2P	LUAA47070	8A2P-A_2A-LUAA47070-Na
7.69	Single	8EF6	Morphine	8EF6-μ-Morphine-Gi1/β1/γ2
7.69	Single	8IKH	Q2L	8IKH-CB₁-Q2L-Gi1/β1/γ1
7.69	Single	8J6P	Compound 9n	8J6P-HCA₂-Niacin-Compound 9n-Gi1/β1/γ2
7.69	Single	8JHY	Compound 9n	8JHY-HCA₂-Compound 9n-Gi1/β1/γ2
7.69	Single	8JII	Compound 9n	8JII-HCA₂-Niacin-Compound 9n-Gi1/β1/γ2
7.69	Single	8RWH	StilSwitch2	8RWH-A_2A-StilSwitch2-Na
7.69	Single	8SZF	Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW	8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
7.69	Single	8WPU	Tryptophan; Cinacalcet; PO4; Ca	8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/β1/γ2
7.69	Single	8YH3	N-methyladenosine	8YH3-A_3A-N-methyladenosine-Gi1/β1/γ2
7.69	Single	8YN4	Histamine	8YN4-H₂-Histamine-chim(NtGi1L-Gs-CtGq)/β1/γ2
7.69	Single	9J5V	CpY	9J5V-LPA₁-CpY-Gi1/β1/γ2
7.69	Single	9L3Z	LRH7-C2	9L3Z-CML1-LRH7-C2
7.69	Consensus	5ht4_on	Orthosteric Ligand	7XTA-5-HT₄-Serotonin-Gi1/β1/γ2
7.69	Consensus	5ht4_on_gp	Orthosteric Ligand	7XTA-5-HT₄-Serotonin-Gi1/β1/γ2
7.69	Consensus	d3_off	Orthosteric Ligand	3PBL-D₃-Eticlopride
7.69	Consensus	npy4_on	Orthosteric Ligand	7X9C-Y₄-Pancreatic Hormone-Gi1/β1/γ2
7.69	Consensus	npy4_on_gp	Orthosteric Ligand	7X9C-Y₄-Pancreatic Hormone-Gi1/β1/γ2
7.41	Single	7F53	Alpha-MSH	7F53-MC₄-α-MSH-Gs/β1/γ2
7.41	Single	7YOO	Neuropeptide-Y	7YOO-Y₂-Neuropeptide-Y-Gi1/β1/γ2
7.41	Single	8ZH8	QRF-Amide	8ZH8-QRFP-QRF-Amide-Gq/β1/γ1
7.41	Single	9K26	PrRP31	9K26-PrRP-PrRP31-Gi1/β1/γ2
7.41	Consensus	npy2_on	Orthosteric Ligand	7YOO-Y₂-Neuropeptide-Y-Gi1/β1/γ2
7.41	Consensus	npy2_on_gp	Orthosteric Ligand	7YOO-Y₂-Neuropeptide-Y-Gi1/β1/γ2
7.41	Consensus	p2y10_on_gp	Orthosteric Ligand	8KGG-P2Y10-LPS-chim(NtGi2-G13)/β1/γ2
7.14	Single	2X72	All-trans-Retinal	2X72-Rhodopsin-All-trans-Retinal-Gt(CT)
7.14	Single	3PWH	ZM-241385	3PWH-A_2A-ZM-241385
7.14	Single	3VG9	ZM-241385	3VG9-A_2A-ZM-241385-Antibody
7.14	Single	4S0V	Suvorexant	4S0V-OX₂-Suvorexant
7.14	Single	5K2D	ZM-241385	5K2D-A_2A-ZM-241385-Na
7.14	Single	5OLH	Vipadenant	5OLH-A_2A-Vipadenant-Na
7.14	Single	5OLO	Tozadenant	5OLO-A_2A-Tozadenant-Na
7.14	Single	5OLV	LUAA41063	5OLV-A_2A-LUAA41063-Na
7.14	Single	5WS3	EMPA	5WS3-OX₂-EMPA
7.14	Single	6AKX	A4R	6AKX-CCR5-A4R
7.14	Single	6B73	MP1104	6B73-κ-MP1104
7.14	Single	6D9H	Adenosine	6D9H-A₁-Adenosine-Gi2/β1/γ2
7.14	Single	6DS0	Ly266097	6DS0-5-HT_2B-Ly266097
7.14	Single	6FKB	PubChem 132473038	6FKB-Rhodopsin-PubChem 132473038
7.14	Single	6JZH	ZM-241385	6JZH-A_2A-ZM-241385-Na
7.14	Single	6NWE	Octyl-Beta-D-Glucopyranoside	6NWE-Rhodopsin-Octyl-β-D-Glucopyranoside-Gt(CT)
7.14	Single	6PS7	ZM-241385	6PS7-A_2A-ZM-241385-Na
7.14	Single	6TOD	EMPA	6TOD-OX₁-EMPA-Na
7.14	Single	6TPJ	Suvorexant	6TPJ-OX₂-Suvorexant
7.14	Single	6TQ6	PubChem 145714283	6TQ6-OX₁-PubChem 145714283
7.14	Single	6ZA8	RTI-3a	6ZA8-NTS₁-RTI-3a
7.14	Single	7BR3	Elagolix	7BR3-GnRH₁-Elagolix
7.14	Single	7DHR	Isoprenaline	7DHR-β₂-Isoprenaline-Gs/β1/γ2
7.14	Single	7EJ0	L-Norepinephrine	7EJ0-α_2a-L-Norepinephrine-Go/β1/γ2
7.14	Single	7F1O	Dopamine	7F1O-D₁-Dopamine-GDP; Mg-Gs/β1/γ2
7.14	Single	7F8U	Lintitript	7F8U-CCK_A-Lintitript
7.14	Single	7F8Y	Devazepide	7F8Y-CCK_A-Devazepide
7.14	Single	7LD4	Adenosine	7LD4-A₁-Adenosine-Gi2/β1/γ2
7.14	Single	7LJD	Dopamine	7LJD-D₁-Dopamine-Mevidalen-Gs/β1/γ1
7.14	Single	7M3E	Ca; Ca; Tryptophan; NPS-2143	7M3E-CaS-Ca; Ca; Tryptophan; NPS-2143
7.14	Single	7M3E	Ca; Ca; Tryptophan; NPS-2143	7M3E-CaS-Ca; Ca; Tryptophan; NPS-2143
7.14	Single	7M3F	Ca; Ca; Tryptophan; Cinacalcet; PO4	7M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
7.14	Single	7SIL	Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4	7SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
7.14	Single	7SIL	Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4	7SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
7.14	Single	7SRR	LSD	7SRR-5-HT_2B-LSD-chim(NtGi2L-Gs-CtGq)/β1/γ2
7.14	Single	7SRS	LSD	7SRS-5-HT_2B-LSD-Arrestin2
7.14	Single	7VGX	Neuropeptide-Y	7VGX-Y₁-Neuropeptide-Y-Gi1/β1/γ2
7.14	Single	7VUJ	JNJ-63533054	7VUJ-GPR139-JNJ-63533054-GDP-chim(Gs-CtGq)/β1/γ2
7.14	Single	7W0M	PubChem 122701908	7W0M-Apelin-PubChem 122701908-Gi1/β1/γ2
7.14	Single	7WV9	ZCZ011	7WV9-CB₁-CP55940-ZCZ011-Gi2/β1/γ2
7.14	Single	7X2F	Dopamine	7X2F-D₁-Dopamine-Mevidalen-Gs/β1/γ2
7.14	Single	7X5H	5-CT	7X5H-5-HT_5A-5-CT-Gi1/β1/γ2
7.14	Single	7XRR	Lemborexant	7XRR-OX₂-Lemborexant
7.14	Single	7XT8	Serotonin	7XT8-5-HT₄-Serotonin-Gs/β1/γ2
7.14	Single	8DU3	PubChem 105526064	8DU3-A_2A-PubChem 105526064
7.14	Single	8DWG	ML382	8DWG-MRGPRX1-Proenkephalin-A-ML382-chim(NtGi2L-Gs-CtGq)/β1/γ2
7.14	Single	8EFO	PZM21	8EFO-μ-PZM21-Gi1/β1/γ2
7.14	Single	8GGZ	Constrained Epinephrine	8GGZ-β₂-Constrained Epinephrine
7.14	Single	8GNG	Istradefylline	8GNG-A_2A-Istradefylline
7.14	Single	8H8J	Lodoxamide	8H8J-GPR35-Lodoxamide-Ca-chim(NtGi1L-G13)/β1/γ2
7.14	Single	8HDP	Adenosine	8HDP-A_2B-Adenosine-Gs/β1/γ2
7.14	Single	8J20	Valeric acid	8J20-FFA3-Valeric acid-AR420626-Gi1/β1/γ2
7.14	Single	8RVW	StilSwitch3	8RVW-A_2A-StilSwitch3-Na
7.14	Single	8RW0	Istradefylline	8RW0-A_2A-Istradefylline-Na
7.14	Single	8RW4	AzoSwitch2	8RW4-A_2A-AzoSwitch2-Na
7.14	Single	8RWE	StilSwitch4	8RWE-A_2A-StilSwitch4-Na
7.14	Single	8SZG	Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW	8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-chim(NtGi1-Gq)/β1/γ2
7.14	Single	8T3V	Docosa-4,7,10,13,16,19-Hexaenoic acid	8T3V-FFA1-Docosa-4,7,10,13,16,19-Hexaenoic acid-chim(NtGi2L-Gs-CtGq)/β1/γ2
7.14	Single	8TZQ	L-Dopamine	8TZQ-D₂-L-Dopamine-Go/β1/γ2
7.14	Single	8UNS	Constrained Epinephrine	8UNS-β₂-Constrained Epinephrine-GTP-Gs/β1/γ2
7.14	Single	8UNT	Constrained Epinephrine	8UNT-β₂-Constrained Epinephrine-GTP-Gs/β1/γ2
7.14	Single	8UNX	Constrained Epinephrine	8UNX-β₂-Constrained Epinephrine-GTP-Gs/β1/γ2
7.14	Single	8WPG	Tryptophan; Cinacalcet; PO4; Ca	8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
7.14	Single	8YUT	Amthamine	8YUT-H₂-Amthamine-Gs/β1/γ2
7.14	Single	9AVL	Ca; Ca; Cyclomethyltryptophan; 9IG; PO4	9AVL-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi3/β2/γ2
7.14	Single	9C2F	Ca; Ca; Tryptophan; '6218; PO4	9C2F-CaS-Ca-Ca; Ca; Tryptophan; '6218; PO4
7.14	Single	9FUP	Istradefylline	9FUP-A_2A-Istradefylline-Na
7.14	Single	9MQJ	Isoquinuclidine	9MQJ-μ-Isoquinuclidine
7.14	Consensus	5ht1e_on	Orthosteric Ligand	7E33-5-HT_1E-BRL-54443-Gi1/β1/γ2 8UGY-5-HT_1E-Mianserin-Gi1/β1/γ1 8UH3-5-HT_1E-Setiptiline-Gi1/β1/γ1
7.14	Consensus	5ht2_on_gp	Orthosteric Ligand	5ht2b_on_gp
7.14	Consensus	5ht2b_on_gp	Orthosteric Ligand	7SRR-5-HT_2B-LSD-chim(NtGi2L-Gs-CtGq)/β1/γ2
7.14	Consensus	5ht_on	Orthosteric Ligand	5ht1_on 5ht2_on 5ht4_on 5ht5_on 5ht6_on 5ht7_on
7.14	Consensus	a1_on	Orthosteric Ligand	7LD4-A₁-Adenosine-Gi2/β1/γ2
7.14	Consensus	a1_on_gp	Orthosteric Ligand	7LD4-A₁-Adenosine-Gi2/β1/γ2
7.14	Consensus	alpha2_off	Orthosteric Ligand	alpha2c_off
7.14	Consensus	gnrh1_off	Orthosteric Ligand	7BR3-GnRH₁-Elagolix
7.14	Consensus	gs_5ht	Orthosteric Ligand	7XTC-5-HT₇-5-CT-Gs/β1/γ2 7XTB-5-HT₆-Serotonin-Gs/β1/γ2 8JLZ-5-HT₆-ST1936-Gs/β1/γ2 7XT8-5-HT₄-Serotonin-Gs/β1/γ2
7.14	Consensus	gs_melanocortin	Orthosteric Ligand	7F4H-MC₁-Afamelanotide-chim(NtGi1-Gs)/β1/γ2 7F54-MC₄-Afamelanotide-Gs/β1/γ2 7F4D-MC₁-α-MSH-chim(NtGi1-Gs)/β1/γ2 8INR-MC₅-α-MSH-Ca-chim(NtGi1-Gs)/β1/γ2 7F53-MC₄-α-MSH-Gs/β1/γ2 7F55-MC₄-Bremelanotide-Gs/β1/γ2 8GY7-MC₂-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1 8IOC-MC₃-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2 8IOD-MC₅-PG-901-Ca-chim(NtGi1-Gs)/β1/γ2 7AUE-MC₄-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2 7F4I-MC₁-SHU9119-chim(NtGi1-Gs)/β1/γ2 7F58-MC₄-THIQ-Gs/β1/γ2
7.14	Consensus	orexin_off	Orthosteric Ligand	ox2_off ox1_off
7.14	Consensus	ox1_off	Orthosteric Ligand	6TP6-OX₁-Filorexant 6TP4-OX₁-ACT-462206 6V9S-OX₁-GTPL11403 6TOT-OX₁-Lemborexant 6TP3-OX₁-Nemorexant 6TQ6-OX₁-PubChem 145714283 6TQ9-OX₁-SB-408124 4ZJC-OX₁-SB-674042 4ZJ8-OX₁-Suvorexant 6TOD-OX₁-EMPA-Na 6TOS-OX₁-GSK1059865-Na 6TQ4-OX₁-PubChem 16046844-Na
7.14	Consensus	ox2_off	Orthosteric Ligand	5WQC-OX₂-EMPA 6TPN-OX₂-HTL6641 7XRR-OX₂-Lemborexant 6TPJ-OX₂-Suvorexant
6.90	Consensus	gi_npy	Orthosteric Ligand	8K6M-Y₁-Neuropeptide-Y-Gi2/β1/γ1 7X9C-Y₄-Pancreatic Hormone-Gi1/β1/γ2 7YOO-Y₂-Neuropeptide-Y-Gi1/β1/γ2
6.90	Consensus	npy_on	Orthosteric Ligand	npy1_on npy2_on npy4_on
6.90	Consensus	npy_on_gp	Orthosteric Ligand	npy1_on_gp npy2_on_gp npy4_on_gp
6.67	Single	2YDO	Adenosine	2YDO-A_2A-Adenosine
6.67	Single	3REY	XAC	3REY-A_2A-XAC
6.67	Single	3RZE	Cidoxepin	3RZE-H₁-Cidoxepin
6.67	Single	3UZC	4-(3-amino-5-phenyl-1,2,4-triazin-6-yl)-2-chlorophenol	3UZC-A_2A-4-(3-amino-5-phenyl-1,2,4-triazin-6-yl)-2-chlorophenol
6.67	Single	4DKL	Beta-Funaltrexamine	4DKL-μ-β-Funaltrexamine
6.67	Single	4LDO	L-Epinephrine	4LDO-β₂-L-Epinephrine
6.67	Single	4MBS	Maraviroc	4MBS-CCR5-Maraviroc
6.67	Single	4N6H	Naltrindole	4N6H-δ-Naltrindole-Na
6.67	Single	4ZJC	SB-674042	4ZJC-OX₁-SB-674042
6.67	Single	5IU4	ZM-241385	5IU4-A_2A-ZM-241385-Na
6.67	Single	5IU7	Q27456346	5IU7-A_2A-Q27456346-Na
6.67	Single	5IUB	Q27456344	5IUB-A_2A-Q27456344-Na
6.67	Single	5JTB	ZM-241385	5JTB-A_2A-ZM-241385
6.67	Single	5K2B	ZM-241385	5K2B-A_2A-ZM-241385-Na
6.67	Single	5K2C	ZM-241385	5K2C-A_2A-ZM-241385-Na
6.67	Single	5NLX	ZM-241385	5NLX-A_2A-ZM-241385-Na
6.67	Single	5NM4	ZM-241385	5NM4-A_2A-ZM-241385-Na
6.67	Single	5TE3	Octyl-Beta-D-Glucopyranoside	5TE3-Rhodopsin-Octyl-β-D-Glucopyranoside
6.67	Single	5UVI	ZM-241385	5UVI-A_2A-ZM-241385
6.67	Single	6AQF	ZM-241385	6AQF-A_2A-ZM-241385
6.67	Single	6FK8	PubChem 132473035	6FK8-Rhodopsin-PubChem 132473035
6.67	Single	6FKA	PubChem 132473037	6FKA-Rhodopsin-PubChem 132473037
6.67	Single	6IQL	L745870	6IQL-D₄-L745870
6.67	Single	6K41	Dexmedetomidine	6K41-α_2b-Dexmedetomidine-Go/β1/γ2
6.67	Single	6MH8	ZM-241385	6MH8-A_2A-ZM-241385
6.67	Single	6PEL	Citronellol	6PEL-Rhodopsin-Citronellol-Gt(CT)
6.67	Single	6PS0	S-Carazolol	6PS0-β₂-S-Carazolol
6.67	Single	6PS4	ICI118-551	6PS4-β₂-ICI118-551
6.67	Single	6PS5	S-Propranolol	6PS5-β₂-S-Propranolol
6.67	Single	6TOS	GSK1059865	6TOS-OX₁-GSK1059865-Na
6.67	Single	6TP3	Nemorexant	6TP3-OX₁-Nemorexant
6.67	Single	6TPG	EMPA	6TPG-OX₂-EMPA
6.67	Single	6TPK	Retosiban	6TPK-OT-Retosiban
6.67	Single	6TPN	HTL6641	6TPN-OX₂-HTL6641
6.67	Single	6V9S	GTPL11403	6V9S-OX₁-GTPL11403
6.67	Single	6VI4	JDTic	6VI4-κ-JDTic
6.67	Single	6WJC	Muscarinic toxin 7	6WJC-M₁-Atropine-Muscarinic toxin 7
6.67	Single	6ZDR	HMS1413f12	6ZDR-A_2A-HMS1413f12-Na
6.67	Single	6ZDV	Chromone 5d	6ZDV-A_2A-Chromone 5d-Na
6.67	Single	6ZIN	SR48692	6ZIN-NTS₁-SR48692
6.67	Single	7ARO	LUF5833	7ARO-A_2A-LUF5833-Na
6.67	Single	7BB6	AVP	7BB6-V₂-AVP-Gs/β1/γ2
6.67	Single	7CKW	Fenoldopam	7CKW-D₁-Fenoldopam-Gs/β1/γ2
6.67	Single	7CKZ	Dopamine	7CKZ-D₁-Dopamine-Mevidalen-Gs/β1/γ2
6.67	Single	7CMU	Pramipexole	7CMU-D₃-Pramipexole-Gi1/β1/γ2
6.67	Single	7CMV	PD128907	7CMV-D₃-PD128907-Gi1/β1/γ2
6.67	Single	7E33	BRL-54443	7E33-5-HT_1E-BRL-54443-Gi1/β1/γ2
6.67	Single	7EJ8	Brimonidine	7EJ8-α_2a-Brimonidine-Go/β1/γ2
6.67	Single	7EJA	Dexmedetomidine	7EJA-α_2a-Dexmedetomidine-Go/β1/γ2
6.67	Single	7F0T	Dopamine	7F0T-D₁-Dopamine-Gs/β1/γ2
6.67	Single	7F1Z	Dopamine	7F1Z-D₁-Dopamine-GDP-Gs/β1/γ2
6.67	Single	7F24	Dopamine	7F24-D₁-Dopamine-GDP-Gs/β1/γ2
6.67	Single	7RAN	PubChem 164575847	7RAN-5-HT_2A-PubChem 164575847-chim(NtGi2L-Gs-CtGq)/β1/γ2
6.67	Single	7SR8	TAK-925	7SR8-OX₂-TAK-925-chim(NtGi1L-Gs-CtGq)/β1/γ2
6.67	Single	7WC9	PubChem 162421364	7WC9-5-HT_2A-PubChem 162421364
6.67	Single	7XOV	SR146131	7XOV-CCK_A-SR146131-Gs/β1/γ2
6.67	Single	8GED	Constrained Epinephrine	8GED-β₂-Constrained Epinephrine-Gs/β1/γ2
6.67	Single	8GG5	Constrained Epinephrine	8GG5-β₂-Constrained Epinephrine-GTP-Gs/β1/γ2
6.67	Single	8GG7	Constrained Epinephrine	8GG7-β₂-Constrained Epinephrine-GTP-Gs/β1/γ2
6.67	Single	8GGL	Constrained Epinephrine	8GGL-β₂-Constrained Epinephrine
6.67	Single	8GGM	Constrained Epinephrine	8GGM-β₂-Constrained Epinephrine
6.67	Single	8GGP	Constrained Epinephrine	8GGP-β₂-Constrained Epinephrine
6.67	Single	8GGQ	Constrained Epinephrine	8GGQ-β₂-Constrained Epinephrine
6.67	Single	8GGX	Constrained Epinephrine	8GGX-β₂-Constrained Epinephrine
6.67	Single	8H4L	Doconexent	8H4L-FFA4-Doconexent-chim(NtGi1-Gs-CtGq)/β1/γ2
6.67	Single	8IYX	YL-365	8IYX-GPR34-YL-365
6.67	Single	8K4S	DCA-3P	8K4S-MRGPRX4-DCA-3P-chim(NtGi1L-Gs-CtGq)/β1/γ2
6.67	Single	8K9K	Damgo	8K9K-μ-Damgo-Gi3/β1/γ1
6.67	Single	8K9L	Damgo	8K9L-μ-Damgo-VV9-Gi3/β1/γ1
6.67	Single	8RQQ	ZM-241385	8RQQ-A_2A-ZM-241385-Na
6.67	Single	8RWC	StilSwitch2	8RWC-A_2A-StilSwitch2-Na
6.67	Single	8RWD	StilSwitch3	8RWD-A_2A-StilSwitch3-Na
6.67	Single	8RWI	StilSwitch2	8RWI-A_2A-StilSwitch2-Na
6.67	Single	8THL	Epinephrine	8THL-Alpha1A-Epinephrine-chim(NtGi2L-Gs-CtGq)/β1/γ2
6.67	Single	8U02	L-Dopamine	8U02-D₂-L-Dopamine-Go/β1/γ2
6.67	Single	8UNL	Constrained Epinephrine	8UNL-β₂-Constrained Epinephrine-GTP-Gs/β1/γ2
6.67	Single	8UNM	Constrained Epinephrine	8UNM-β₂-Constrained Epinephrine-GTP-Gs/β1/γ2
6.67	Single	8UNO	Constrained Epinephrine	8UNO-β₂-Constrained Epinephrine-GTP-Gs/β1/γ2
6.67	Single	8UNW	Constrained Epinephrine	8UNW-β₂-Constrained Epinephrine-GTP-Gs/β1/γ2
6.67	Single	8UO0	Constrained Epinephrine	8UO0-β₂-Constrained Epinephrine-GTP-Gs/β1/γ2
6.67	Single	8UO1	Constrained Epinephrine	8UO1-β₂-Constrained Epinephrine-GTP; Mg-Gs/β1/γ2
6.67	Single	8VVG	GB18	8VVG-κ-GB18-Gi1/β1/γ2
6.67	Single	8WPG	Tryptophan; Cinacalcet; PO4; Ca	8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
6.67	Single	8WPU	Tryptophan; Cinacalcet; PO4; Ca	8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/β1/γ2
6.67	Single	8Y01	Retinal	8Y01-Opsin1MW-Retinal-Gi1/β1/γ2
6.67	Single	8Y45	ADL5859	8Y45-δ-ADL5859-Gi2/β1/γ2
6.67	Single	8Y53	MK5046	8Y53-BB₃-MK5046-chim(NtGi1-Gs-CtGq)/β1/γ2
6.67	Single	8YH2	Adenosine	8YH2-A_3A-Adenosine-Gi1/β1/γ2
6.67	Single	8YN3	Histamine	8YN3-H₂-Histamine-Gs/β1/γ2
6.67	Single	9ASB	Ca; Ca; Cyclomethyltryptophan; 9IG; PO4	9ASB-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
6.67	Single	9ASB	Ca; Ca; Cyclomethyltryptophan; 9IG; PO4	9ASB-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
6.67	Single	9AVG	Ca; Ca; Cyclomethyltryptophan; 9IG; PO4	9AVG-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs)/β1/γ2
6.67	Single	9AXF	Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4	9AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
6.67	Single	9BJK	Naloxone	9BJK-μ-Naloxone-NAM
6.67	Single	9K1D	Butanoic acid	9K1D-FFA2-Butanoic acid-Cholesterol-Gi1/β1/γ2
6.67	Single	9MQI	Isoquinuclidine	9MQI-μ-Isoquinuclidine
6.67	Consensus	5ht_on_gp	Orthosteric Ligand	5ht1_on_gp 5ht2_on_gp 5ht4_on_gp 5ht5_on_gp 5ht6_on_gp 5ht7_on_gp
6.67	Consensus	a2_off	Orthosteric Ligand	a2a_off
6.67	Consensus	a2a_off	Orthosteric Ligand	3RFM-A_2A-Caffeine 8C9W-A_2A-Etrumadenant 3UZA-A_2A-GTPL9236 8GNG-A_2A-Istradefylline 8CU6-A_2A-LJ-4517 7PX4-A_2A-PSB-2113 7PYR-A_2A-PSB-2115 8DU3-A_2A-PubChem 105526064 8JWY-A_2A-2-118 8PWN-A_2A-Theophylline 5IU4-A_2A-ZM-241385-Na 5OLZ-A_2A-PubChem 135566609-Na 6GT3-A_2A-Imaradenant-Na 5OLV-A_2A-LUAA41063-Na 5N2R-A_2A-PSB-36-Na 5IU7-A_2A-Q27456346-Na 5OLH-A_2A-Vipadenant-Na 5OLO-A_2A-Tozadenant-Na 6ZDR-A_2A-HMS1413f12-Na 8GNE-A_2A-KW-6356-Na 8JWZ-A_2A-AB928-Na 5IU8-A_2A-Q27456347-Na 5IUB-A_2A-Q27456344-Na 6ZDV-A_2A-Chromone 5d-Na 5IUA-A_2A-Q27456348-Na 8A2P-A_2A-LUAA47070-Na
6.67	Consensus	adenosine_on	Orthosteric Ligand	a1_on a2_on a3_on
6.67	Consensus	alpha1_on	Orthosteric Ligand	alpha1a_on
6.67	Consensus	alpha1_on_gp	Orthosteric Ligand	alpha1a_on_gp
6.67	Consensus	alpha1a_on	Orthosteric Ligand	7EJ0-α_2a-L-Norepinephrine-Go/β1/γ2 7EJ8-α_2a-Brimonidine-Go/β1/γ2 7EJA-α_2a-Dexmedetomidine-Go/β1/γ2 7EJK-α_2a-Oxymetazoline-Go/β1/γ2 7W6P-α_2a-N-pyridin-4-ylisoquinolin-4-amine-Go/β1/γ2 7W7E-α_2a-PubChem 164946676-Go/β1/γ2
6.67	Consensus	alpha1a_on_gp	Orthosteric Ligand	7EJ0-α_2a-L-Norepinephrine-Go/β1/γ2 7EJ8-α_2a-Brimonidine-Go/β1/γ2 7EJA-α_2a-Dexmedetomidine-Go/β1/γ2 7EJK-α_2a-Oxymetazoline-Go/β1/γ2 7W6P-α_2a-N-pyridin-4-ylisoquinolin-4-amine-Go/β1/γ2 7W7E-α_2a-PubChem 164946676-Go/β1/γ2
6.67	Consensus	d3_on	Orthosteric Ligand	7CMV-D₃-PD128907-Gi1/β1/γ2 8IRT-D₃-Rotigotine-Gi1/β1/γ2 7CMU-D₃-Pramipexole-Gi1/β1/γ2
6.67	Consensus	d3_on_gp	Orthosteric Ligand	7CMV-D₃-PD128907-Gi1/β1/γ2 8IRT-D₃-Rotigotine-Gi1/β1/γ2 7CMU-D₃-Pramipexole-Gi1/β1/γ2
6.67	Consensus	ghrelin_off	Orthosteric Ligand	6KO5-Ghrelin-PubChem 57400002 7F83-Ghrelin-PF-05190457
6.67	Consensus	gi_adenosine	Orthosteric Ligand	7LD4-A₁-Adenosine-Gi2/β1/γ2 8X17-A_3A-Namodenoson-Gi1/β1/γ2 8X16-A_3A-Piclidenoson-Gi1/β1/γ2
6.67	Consensus	grh_off	Orthosteric Ligand	gnrh1_off
6.67	Consensus	melanocortin_on	Orthosteric Ligand	mc1_on mc4_on mc2_on mc3_on mc5_on
6.67	Consensus	melanocortin_on_gp	Orthosteric Ligand	mc1_on_gp mc4_on_gp mc2_on_gp mc3_on_gp mc5_on_gp
6.67	Consensus	nop_off	Orthosteric Ligand	4EA3-NOP-PubChem 10296561 5DHG-NOP-C-35 5DHH-NOP-SB-612111
6.67	Consensus	nucleotide_off	Orthosteric Ligand	adenosine_off p2y_off
6.67	Consensus	ot_off	Orthosteric Ligand	6TPK-OT-Retosiban
6.67	Consensus	vasop-oxy_off	Orthosteric Ligand	ot_off
6.45	Consensus	gs_peptide	Orthosteric Ligand	gs_cck gs_melanocortin gs_vasop-oxy
6.25	Single	2VT4	Cyanopindolol	2VT4-β₁-Cyanopindolol
6.25	Single	2Y02	Carmoterol	2Y02-β₁-Carmoterol
6.25	Single	2YCY	Cyanopindolol	2YCY-β₁-Cyanopindolol
6.25	Single	3EML	ZM-241385	3EML-A_2A-ZM-241385
6.25	Single	3NY8	ICI118-551	3NY8-β₂-ICI118-551
6.25	Single	3NYA	S-Alprenolol	3NYA-β₂-S-Alprenolol
6.25	Single	3ZPQ	4-(piperazin-1- yl)-1H-indole	3ZPQ-β₁-4-(piperazin-1- yl)-1H-indole-Na
6.25	Single	3ZPR	4-methyl-2-(piperazin-1-yl)	3ZPR-β₁-4-methyl-2-(piperazin-1-yl)-Na
6.25	Single	4EA3	PubChem 10296561	4EA3-NOP-PubChem 10296561
6.25	Single	4EIY	ZM-241385	4EIY-A_2A-ZM-241385-Na
6.25	Single	4EJ4	Naltrindole	4EJ4-δ-Naltrindole
6.25	Single	4GBR	S-Carazolol	4GBR-β₂-S-Carazolol
6.25	Single	4J4Q	Octyl Beta-D-Glucopyranoside	4J4Q-Rhodopsin-Octyl β-D-Glucopyranoside-Gt(CT)
6.25	Single	4QIM	ANTA XV	4QIM-SMO-ANTA XV
6.25	Single	4X1H	Nonyl-Beta-D-Glucopyranoside	4X1H-Rhodopsin-Nonyl-β-D-Glucopyranoside-Gt(CT)
6.25	Single	5DHG	C-35	5DHG-NOP-C-35
6.25	Single	5DHH	SB-612111	5DHH-NOP-SB-612111
6.25	Single	5IU8	Q27456347	5IU8-A_2A-Q27456347-Na
6.25	Single	5K2A	ZM-241385	5K2A-A_2A-ZM-241385-Na
6.25	Single	5OLG	ZM-241385	5OLG-A_2A-ZM-241385-Na
6.25	Single	5OLZ	PubChem 135566609	5OLZ-A_2A-PubChem 135566609-Na
6.25	Single	5OM1	PubChem 135566609	5OM1-A_2A-PubChem 135566609-Na
6.25	Single	5UEN	DU172	5UEN-A₁-DU172
6.25	Single	5UIG	Cmpd-1	5UIG-A_2A-Cmpd-1
6.25	Single	5VRA	ZM-241385	5VRA-A_2A-ZM-241385-Na
6.25	Single	6FK7	PubChem 132473034	6FK7-Rhodopsin-PubChem 132473034
6.25	Single	6FKC	PubChem 132473039	6FKC-Rhodopsin-PubChem 132473039
6.25	Single	6FKD	PubChem 137349183	6FKD-Rhodopsin-PubChem 137349183
6.25	Single	6K42	Dexmedetomidine	6K42-α_2b-Dexmedetomidine-Gi1/β1/γ2
6.25	Single	6LPJ	ZM-241385	6LPJ-A_2A-ZM-241385-Na
6.25	Single	6LPK	ZM-241385	6LPK-A_2A-ZM-241385-Na
6.25	Single	6PRZ	S-Alprenolol	6PRZ-β₂-S-Alprenolol
6.25	Single	6PS1	Timolol	6PS1-β₂-Timolol
6.25	Single	6PS2	S-Alprenolol	6PS2-β₂-S-Alprenolol
6.25	Single	6S0L	ZM-241385	6S0L-A_2A-ZM-241385
6.25	Single	6TOT	Lemborexant	6TOT-OX₁-Lemborexant
6.25	Single	6XBM	25(S)-Epoxycholesterol	6XBM-SMO-25(S)-Epoxycholesterol-Gi1/β1/γ2
6.25	Single	6Z4V	NTS8-13	6Z4V-NTS₁-NTS8-13
6.25	Single	7BTS	L-Epinephrine	7BTS-β₁-L-Epinephrine
6.25	Single	7BU6	L-Norepinephrine	7BU6-β₁-L-Norepinephrine
6.25	Single	7BU7	BI167107	7BU7-β₁-BI167107
6.25	Single	7CRH	SKF83959	7CRH-D₁-SKF83959-Gs/β1/γ2
6.25	Single	7DB6	Ramelteon	7DB6-MT₁-Ramelteon-Gi1/β1/γ2
6.25	Single	7E32	Serotonin	7E32-5-HT_1D-Serotonin-Gi1/β1/γ2
6.25	Single	7FIH	Org43553	7FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/β1/γ2
6.25	Single	7JOZ	VFP	7JOZ-D₁-VFP-Gs/β1/γ2
6.25	Single	7JVQ	Apomorphine	7JVQ-D₁-Apomorphine-Gs/β1/γ2
6.25	Single	7LJC	SKF-81297	7LJC-D₁-SKF-81297-Mevidalen-Gs/β1/γ2
6.25	Single	7M3J	NPS-2143; PO4	7M3J-CaS-NPS-2143; PO4
6.25	Single	7NA8	PubChem 178024	7NA8-Ghrelin-PubChem 178024-Gi1/β1/γ2
6.25	Single	7PYR	PSB-2115	7PYR-A_2A-PSB-2115
6.25	Single	7S0G	Isoprenaline	7S0G-β₁-Isoprenaline-chim(Gi1-CtGs)/β1/γ2
6.25	Single	7SCG	FH210	7SCG-μ-FH210-Gi1/β1/γ2
6.25	Single	7SQO	TAK-925	7SQO-OX₂-TAK-925-Gi1/β1/γ2
6.25	Single	7T2G	Mitragynine Pseudoindoxyl	7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2
6.25	Single	7UL4	Alvimopan	7UL4-μ-Alvimopan
6.25	Single	7UM5	5-CT	7UM5-5-HT_5A-5-CT-chim(NtGi1-Go)/β1/γ2
6.25	Single	7UM6	Lisuride	7UM6-5-HT_5A-Lisuride-chim(NtGi1-Go)/β1/γ2
6.25	Single	7VIE	S1P	7VIE-S1P₁-S1P-Gi1/β1/γ2
6.25	Single	7X2C	Fenoldopam	7X2C-D₁-Fenoldopam-Fenoldopam-Gs/β1/γ2
6.25	Single	7X9A	Neuropeptide-Y	7X9A-Y₁-Neuropeptide-Y-Gi1/β1/γ2
6.25	Single	7XTC	5-CT	7XTC-5-HT₇-5-CT-Gs/β1/γ2
6.25	Single	7YU4	ONO-0740556	7YU4-LPA₁-ONO-0740556
6.25	Single	8CIC	Etrumadenant	8CIC-A_2A-Etrumadenant-Na
6.25	Single	8CU6	LJ-4517	8CU6-A_2A-LJ-4517
6.25	Single	8CU7	LJ-4517	8CU7-A_2A-LJ-4517-Na
6.25	Single	8DZS	GR89,696	8DZS-κ-GR89,696-chim(NtGi2-Gz)/β1/γ2
6.25	Single	8EFQ	Damgo	8EFQ-μ-Damgo-Gi1/β1/γ2
6.25	Single	8EJK	TAK-875	8EJK-FFA1-TAK-875-chim(NtGi1L-Gs-CtGq)/β1/γ2
6.25	Single	8GE3	Constrained Epinephrine	8GE3-β₂-Constrained Epinephrine-Gs/β1/γ2
6.25	Single	8GEC	Constrained Epinephrine	8GEC-β₂-Constrained Epinephrine-Gs/β1/γ2
6.25	Single	8GEE	Constrained Epinephrine	8GEE-β₂-Constrained Epinephrine-Gs/β1/γ2
6.25	Single	8GEH	Constrained Epinephrine	8GEH-β₂-Constrained Epinephrine-Gs/β1/γ2
6.25	Single	8GFV	Constrained Epinephrine	8GFV-β₂-Constrained Epinephrine-GTP-Gs/β1/γ2
6.25	Single	8GFW	Constrained Epinephrine	8GFW-β₂-Constrained Epinephrine-GTP-Gs/β1/γ2
6.25	Single	8GFX	Constrained Epinephrine	8GFX-β₂-Constrained Epinephrine-GTP-Gs/β1/γ2
6.25	Single	8GFZ	Constrained Epinephrine	8GFZ-β₂-Constrained Epinephrine-GTP-Gs/β1/γ2
6.25	Single	8GG0	Constrained Epinephrine	8GG0-β₂-Constrained Epinephrine-GTP-Gs/β1/γ2
6.25	Single	8GG1	Constrained Epinephrine	8GG1-β₂-Constrained Epinephrine-GTP-Gs/β1/γ2
6.25	Single	8GG3	Constrained Epinephrine	8GG3-β₂-Constrained Epinephrine-GTP-Gs/β1/γ2
6.25	Single	8GG4	Constrained Epinephrine	8GG4-β₂-Constrained Epinephrine-GTP-Gs/β1/γ2
6.25	Single	8GG6	Constrained Epinephrine	8GG6-β₂-Constrained Epinephrine-GTP-Gs/β1/γ2
6.25	Single	8GG9	Constrained Epinephrine	8GG9-β₂-Constrained Epinephrine-GTP-Gs/β1/γ2
6.25	Single	8GGI	Constrained Epinephrine	8GGI-β₂-Constrained Epinephrine
6.25	Single	8GGJ	Constrained Epinephrine	8GGJ-β₂-Constrained Epinephrine
6.25	Single	8GGK	Constrained Epinephrine	8GGK-β₂-Constrained Epinephrine
6.25	Single	8GGN	Constrained Epinephrine	8GGN-β₂-Constrained Epinephrine
6.25	Single	8GGO	Constrained Epinephrine	8GGO-β₂-Constrained Epinephrine
6.25	Single	8GGU	Constrained Epinephrine	8GGU-β₂-Constrained Epinephrine
6.25	Single	8IRT	Rotigotine	8IRT-D₃-Rotigotine-Gi1/β1/γ2
6.25	Single	8JD0	NAM563	8JD0-mGlu2; mGlu3-Glutamate-NAM563
6.25	Single	8JJO	Alprenolol	8JJO-β₂-Alprenolol
6.25	Single	8JLZ	ST1936	8JLZ-5-HT₆-ST1936-Gs/β1/γ2
6.25	Single	8JT8	(R)-IHCH-7179	8JT8-5-HT_2A-(R)-IHCH-7179
6.25	Single	8KEX	DCA-3P	8KEX-MRGPRX4-DCA-3P
6.25	Single	8RLN	LUF5834	8RLN-A_2A-LUF5834
6.25	Single	8RW7	StilSwitch1	8RW7-A_2A-StilSwitch1-Na
6.25	Single	8RWX	StilSwitch3	8RWX-A_2A-StilSwitch3-Na
6.25	Single	8SZH	Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW	8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/β1/γ2
6.25	Single	8UGY	Mianserin	8UGY-5-HT_1E-Mianserin-Gi1/β1/γ1
6.25	Single	8UH3	Setiptiline	8UH3-5-HT_1E-Setiptiline-Gi1/β1/γ1
6.25	Single	8UNQ	Constrained Epinephrine	8UNQ-β₂-Constrained Epinephrine-GTP-Gs/β1/γ2
6.25	Single	8UNR	Constrained Epinephrine	8UNR-β₂-Constrained Epinephrine-GTP-Gs/β1/γ2
6.25	Single	8UNU	Constrained Epinephrine	8UNU-β₂-Constrained Epinephrine-GTP-Gs/β1/γ2
6.25	Single	8UNV	Constrained Epinephrine	8UNV-β₂-Constrained Epinephrine-GTP-Gs/β1/γ2
6.25	Single	8UNY	Constrained Epinephrine	8UNY-β₂-Constrained Epinephrine-GTP-Gs/β1/γ2
6.25	Single	8UNZ	Constrained Epinephrine	8UNZ-β₂-Constrained Epinephrine-GTP-Gs/β1/γ2
6.25	Single	8UO2	Constrained Epinephrine	8UO2-β₂-Constrained Epinephrine-GTP-Gs/β1/γ2
6.25	Single	8X17	Namodenoson	8X17-A_3A-Namodenoson-Gi1/β1/γ2
6.25	Single	8X63	Mepyramine	8X63-H₁-Mepyramine
6.25	Single	8X64	Desloratadine	8X64-H₁-Desloratadine
6.25	Single	8X9T	AP503	8X9T-ADGRD1-AP503-chim(NtGi1-Gs)/β1/γ2
6.25	Single	8XVK	Ambrisentan	8XVK-ET_A-Ambrisentan
6.25	Single	8YH5	Riboprine	8YH5-A_3A-Riboprine-Gi1/β1/γ2
6.25	Single	8ZQE	GPR15L(C11)	8ZQE-GPR15-GPR15L(C11)-Gi1/β1/γ1
6.25	Single	9AVG	Ca; Ca; Cyclomethyltryptophan; 9IG; PO4	9AVG-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs)/β1/γ2
6.25	Single	9CBM	Dexmedetomidine	9CBM-α_2a-Dexmedetomidine-Gi1/β1/γ2
6.25	Single	9CHX	S-Carazolol	9CHX-β₂-S-Carazolol
6.25	Single	9D61	JDTic	9D61-κ-JDTic-Gi1/β1/γ2
6.25	Consensus	5ht1d_on	Orthosteric Ligand	7E32-5-HT_1D-Serotonin-Gi1/β1/γ2
6.25	Consensus	5ht1d_on_gp	Orthosteric Ligand	7E32-5-HT_1D-Serotonin-Gi1/β1/γ2
6.25	Consensus	5ht5_on	Orthosteric Ligand	5ht5a_on
6.25	Consensus	5ht5a_on	Orthosteric Ligand	7X5H-5-HT_5A-5-CT-Gi1/β1/γ2 7UM6-5-HT_5A-Lisuride-chim(NtGi1-Go)/β1/γ2 7UM7-5-HT_5A-Methylergometrine-chim(NtGi1-Go)/β1/γ2
6.25	Consensus	5ht6_on	Orthosteric Ligand	7XTB-5-HT₆-Serotonin-Gs/β1/γ2 8JLZ-5-HT₆-ST1936-Gs/β1/γ2
6.25	Consensus	5ht6_on_gp	Orthosteric Ligand	7XTB-5-HT₆-Serotonin-Gs/β1/γ2 8JLZ-5-HT₆-ST1936-Gs/β1/γ2
6.25	Consensus	5ht7_on	Orthosteric Ligand	7XTC-5-HT₇-5-CT-Gs/β1/γ2
6.25	Consensus	5ht7_on_gp	Orthosteric Ligand	7XTC-5-HT₇-5-CT-Gs/β1/γ2
6.25	Consensus	a3_on	Orthosteric Ligand	a3a_on
6.25	Consensus	adenosine_on_gp	Orthosteric Ligand	a1_on_gp a2_on_gp a3_on_gp
6.25	Consensus	adrenergic_on	Orthosteric Ligand	alpha_on beta_on
6.25	Consensus	alpha2_on	Orthosteric Ligand	alpha2b_on
6.25	Consensus	alpha2_on_gp	Orthosteric Ligand	alpha2b_on_gp
6.25	Consensus	alpha2b_on	Orthosteric Ligand	6K42-α_2b-Dexmedetomidine-Gi1/β1/γ2
6.25	Consensus	alpha2b_on_gp	Orthosteric Ligand	6K42-α_2b-Dexmedetomidine-Gi1/β1/γ2
6.25	Consensus	alpha_on	Orthosteric Ligand	alpha1_on alpha2_on
6.25	Consensus	cck_off	Orthosteric Ligand	ccka_off
6.25	Consensus	ccka_off	Orthosteric Ligand	7F8Y-CCK_A-Devazepide 7F8U-CCK_A-Lintitript
6.25	Consensus	dop_off	Orthosteric Ligand	4EJ4-δ-Naltrindole
6.25	Consensus	dopamine_off	Orthosteric Ligand	d2_off d3_off
6.25	Consensus	dopamine_on	Orthosteric Ligand	d2_on d1_on d3_on d4_on d5_on
6.25	Consensus	dopamine_on_gp	Orthosteric Ligand	d2_on_gp d1_on_gp d3_on_gp d4_on_gp d5_on_gp
6.25	Consensus	gi_orexin	Orthosteric Ligand	7SQO-OX₂-TAK-925-Gi1/β1/γ2
6.25	Consensus	histamine_off	Orthosteric Ligand	h1_off
6.25	Consensus	lipid_off	Orthosteric Ligand	cannabinoid_off paf_off lpl_off prostanoid_off leukotriene_off
6.25	Consensus	nucleotide_offon	Orthosteric Ligand	nucleotide_off nucleotide_on
6.25	Consensus	nucleotide_offon_gp	Orthosteric Ligand	nucleotide_on_gp nucleotide_off
5.88	Single	2RH1	S-Carazolol	2RH1-β₂-S-Carazolol
5.88	Single	2YCW	S-Carazolol	2YCW-β₁-S-Carazolol
5.88	Single	4PHU	Fasiglifam	4PHU-FFA1-Fasiglifam
5.88	Single	4RWD	DIPP-NH2	4RWD-δ-DIPP-NH2-Na
5.88	Single	4ZJ8	Suvorexant	4ZJ8-OX₁-Suvorexant
5.88	Single	5C1M	BU72	5C1M-μ-BU72
5.88	Single	5D6L	S-Carazolol	5D6L-β₂-S-Carazolol
5.88	Single	5IUA	Q27456348	5IUA-A_2A-Q27456348-Na
5.88	Single	5JQH	S-Carazolol	5JQH-β₂-S-Carazolol
5.88	Single	5N2R	PSB-36	5N2R-A_2A-PSB-36-Na
5.88	Single	5N2S	PSB36	5N2S-A₁-PSB36
5.88	Single	5NM2	ZM-241385	5NM2-A_2A-ZM-241385-Na
5.88	Single	5OM4	PubChem 135566609	5OM4-A_2A-PubChem 135566609-Na
5.88	Single	5TVN	LSD	5TVN-5-HT_2B-LSD
5.88	Single	5WQC	EMPA	5WQC-OX₂-EMPA
5.88	Single	5X7D	S-Carazolol	5X7D-β₂-S-Carazolol-PubChem 129318963
5.88	Single	5XPR	Bosentan	5XPR-ET_B-Bosentan
5.88	Single	6E67	BI167107	6E67-β₂-BI167107-Gs (fused)
5.88	Single	6GDG	NECA	6GDG-A_2A-NECA-Gs/β1/γ1
5.88	Single	6KUW	PubChem 57213234	6KUW-α_2c-PubChem 57213234
5.88	Single	6LPL	ZM-241385	6LPL-A_2A-ZM-241385-Na
5.88	Single	6PS3	S-Carvedilol	6PS3-β₂-S-Carvedilol
5.88	Single	6PS6	Timolol	6PS6-β₂-Timolol
5.88	Single	6S0Q	ZM-241385	6S0Q-A_2A-ZM-241385
5.88	Single	6TO7	Suvorexant	6TO7-OX₁-Suvorexant-Na
5.88	Single	6TP6	Filorexant	6TP6-OX₁-Filorexant
5.88	Single	6W2X	PubChem 23727970	6W2X-GABA_B1, GABA_B2-PubChem 5311042-PubChem 23727970
5.88	Single	6W2X	PubChem 23727970	6W2X-GABA_B1, GABA_B2-PubChem 5311042-PubChem 23727970
5.88	Single	6WQA	ZM-241385	6WQA-A_2A-ZM-241385-Na
5.88	Single	6XBK	Cholesterol	6XBK-SMO-Cholesterol-Gi1/β1/γ2
5.88	Single	6Z4S	SR48692	6Z4S-NTS₁-SR48692
5.88	Single	7BVQ	S-Carazolol	7BVQ-β₁-S-Carazolol
5.88	Single	7C61	Ergotamine	7C61-5-HT_1B-Ergotamine
5.88	Single	7CFN	INT-777	7CFN-GPBA-INT-777-Gs/β1/γ2
5.88	Single	7CKX	A77636	7CKX-D₁-A77636-Gs/β1/γ2
5.88	Single	7EPF	NAM597	7EPF-mGlu2; mGlu2-NAM597
5.88	Single	7LD3	Adenosine	7LD3-A₁-Adenosine-PubChem 25263603-Gi2/β1/γ2
5.88	Single	7M3J	NPS-2143; PO4	7M3J-CaS-NPS-2143; PO4
5.88	Single	7RM5	ZM-241385	7RM5-A_2A-ZM-241385-Na
5.88	Single	7S0F	Isoprenaline	7S0F-β₁-Isoprenaline-Gi1/β1/γ2
5.88	Single	7SBF	PZM21	7SBF-μ-PZM21-Gi1/β1/γ2
5.88	Single	7SIN	NPS-2143	7SIN-CaS-NPS-2143
5.88	Single	7SIN	NPS-2143	7SIN-CaS-NPS-2143
5.88	Single	7VUH	JNJ-63533054	7VUH-GPR139-JNJ-63533054-chim(Gs-CtGq)/β1/γ2
5.88	Single	7VV4	Cortistatin-14	7VV4-MRGPRX2-Cortistatin-14
5.88	Single	7W41	PD176252	7W41-BB₂-PD176252
5.88	Single	7WC6	LSD	7WC6-5-HT_2A-LSD
5.88	Single	7WIG	L-054,264	7WIG-SST2-L-054,264-Gi1/β1/γ2
5.88	Single	7X1T	Taltirelin	7X1T-TRH-Taltirelin-chim(NtGi2L-Gs-CtGq)/β1/γ2
5.88	Single	7XK9	Constrained Isoproterenol	7XK9-β₂-Constrained Isoproterenol-Na
5.88	Single	7XKA	Constrained Epinephrine	7XKA-β₂-Constrained Epinephrine
5.88	Single	7Y26	Octreotide	7Y26-SST2-Octreotide-chim(NtGi2L-Gs-CtGq)/β1/γ2
5.88	Single	7YU3	ONO-0740556	7YU3-LPA₁-ONO-0740556-Gi1/β1/γ2
5.88	Single	7YU6	ONO-0740556	7YU6-LPA₁-ONO-0740556-Gi1/β1/γ2
5.88	Single	8C9W	Etrumadenant	8C9W-A_2A-Etrumadenant
5.88	Single	8DZQ	momSalB	8DZQ-κ-momSalB-Go/β1/γ2
5.88	Single	8DZR	GR89,696	8DZR-κ-GR89,696-chim(NtGi2-Gt3)/β1/γ2
5.88	Single	8EJC	TAK-875	8EJC-FFA1-TAK-875-chim(NtGi1L-Gs-CtGq)/β1/γ2
5.88	Single	8FYN	ZM-241385	8FYN-A_2A-ZM-241385-Na
5.88	Single	8GDZ	Constrained Epinephrine	8GDZ-β₂-Constrained Epinephrine-Gs/β1/γ2
5.88	Single	8GEB	Constrained Epinephrine	8GEB-β₂-Constrained Epinephrine-Gs/β1/γ2
5.88	Single	8GEG	Constrained Epinephrine	8GEG-β₂-Constrained Epinephrine-Gs/β1/γ2
5.88	Single	8GFY	Constrained Epinephrine	8GFY-β₂-Constrained Epinephrine-GTP-Gs/β1/γ2
5.88	Single	8GG2	Constrained Epinephrine	8GG2-β₂-Constrained Epinephrine-GTP-Gs/β1/γ2
5.88	Single	8GGB	Constrained Epinephrine	8GGB-β₂-Constrained Epinephrine-GTP-Gs/β1/γ2
5.88	Single	8GNE	KW-6356	8GNE-A_2A-KW-6356-Na
5.88	Single	8ID4	Linoleic acid	8ID4-FFA4-Linoleic acid-Gi1/β1/γ2
5.88	Single	8K8J	Fenofibrate	8K8J-CB₁-Fenofibrate-chim(Gs-CtGq)/β1/γ2
5.88	Single	8KFX	LMD-009	8KFX-CCR8-LMD-009-Gi1/β1/γ2
5.88	Single	8QOT	Nanobody-E	8QOT-μ-Nanobody-E
5.88	Single	8S4D	CMF-019	8S4D-Apelin-CMF-019
5.88	Single	8SZG	Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW	8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-chim(NtGi1-Gq)/β1/γ2
5.88	Single	8SZI	Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW	8SZI-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi3/β1/γ2
5.88	Single	8TF5	Oleic acid	8TF5-GPR6-Oleic acid
5.88	Single	8UNN	Constrained Epinephrine	8UNN-β₂-Constrained Epinephrine-GTP-Gs/β1/γ2
5.88	Single	8UNP	Constrained Epinephrine	8UNP-β₂-Constrained Epinephrine-GTP-Gs/β1/γ2
5.88	Single	8VVE	norBNI	8VVE-κ-norBNI-Gi1/β1/γ2
5.88	Single	8WGB	W9R	8WGB-mGlu4; mGlu2-Glutammate-W9R-Gi3/β1/γ2
5.88	Single	8X0B	VU0424465	8X0B-mGlu5; mGlu5-Quisqualate-VU0424465
5.88	Single	8X0D	VU0424465	8X0D-mGlu5; mGlu5-Quisqualate-VU0424465
5.88	Single	8X0D	VU0424465	8X0D-mGlu5; mGlu5-Quisqualate-VU0424465
5.88	Single	8YH0	NECA	8YH0-A_3A-NECA-Gi1/β1/γ2
5.88	Single	9AVL	Ca; Ca; Cyclomethyltryptophan; 9IG; PO4	9AVL-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi3/β2/γ2
5.88	Single	9AXF	Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4	9AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
5.88	Single	9AYF	Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4	9AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/β1/γ2
5.88	Single	9MQK	Isoquinuclidine	9MQK-κ-Isoquinuclidine
5.88	Consensus	5ht1_on	Orthosteric Ligand	5ht1a_on 5ht1d_on 5ht1e_on 5ht1f_on
5.88	Consensus	5ht1_on_gp	Orthosteric Ligand	5ht1a_on_gp 5ht1d_on_gp 5ht1e_on_gp 5ht1f_on_gp
5.88	Consensus	5ht1e_on_gp	Orthosteric Ligand	7E33-5-HT_1E-BRL-54443-Gi1/β1/γ2 8UGY-5-HT_1E-Mianserin-Gi1/β1/γ1 8UH3-5-HT_1E-Setiptiline-Gi1/β1/γ1
5.88	Consensus	5ht5_on_gp	Orthosteric Ligand	5ht5a_on_gp
5.88	Consensus	5ht5a_on_gp	Orthosteric Ligand	7X5H-5-HT_5A-5-CT-Gi1/β1/γ2 7UM6-5-HT_5A-Lisuride-chim(NtGi1-Go)/β1/γ2 7UM7-5-HT_5A-Methylergometrine-chim(NtGi1-Go)/β1/γ2
5.88	Consensus	a1_off	Orthosteric Ligand	5UEN-A₁-DU172 5N2S-A₁-PSB36
5.88	Consensus	a3_on_gp	Orthosteric Ligand	a3a_on_gp
5.88	Consensus	a3a_on	Orthosteric Ligand	8X17-A_3A-Namodenoson-Gi1/β1/γ2 8X16-A_3A-Piclidenoson-Gi1/β1/γ2
5.88	Consensus	a3a_on_gp	Orthosteric Ligand	8X17-A_3A-Namodenoson-Gi1/β1/γ2 8X16-A_3A-Piclidenoson-Gi1/β1/γ2
5.88	Consensus	adenosine_off	Orthosteric Ligand	a1_off a2_off
5.88	Consensus	adrenergic_off	Orthosteric Ligand	alpha_off beta_off
5.88	Consensus	adrenergic_on_gp	Orthosteric Ligand	alpha_on_gp beta_on_gp
5.88	Consensus	alpha2c_off	Orthosteric Ligand	6KUW-α_2c-PubChem 57213234
5.88	Consensus	alpha_off	Orthosteric Ligand	alpha1_off alpha2_off
5.88	Consensus	alpha_on_gp	Orthosteric Ligand	alpha1_on_gp alpha2_on_gp
5.88	Consensus	amine_off	Orthosteric Ligand	5ht_off adrenergic_off dopamine_off histamine_off muscarinic_off
5.88	Consensus	amine_offon	Orthosteric Ligand	amine_off amine_on
5.88	Consensus	amine_offon_gp	Orthosteric Ligand	amine_on_gp amine_off
5.88	Consensus	amine_on	Orthosteric Ligand	5ht_on adrenergic_on dopamine_on histamine_on muscarinic_on trace-amine_on
5.88	Consensus	bb2_off	Orthosteric Ligand	7W41-BB₂-PD176252
5.88	Consensus	beta2_off	Orthosteric Ligand	2RH1-β₂-S-Carazolol 6PS3-β₂-S-Carvedilol 6PS5-β₂-S-Propranolol 3D4S-β₂-Timolol 3NY8-β₂-ICI118-551 3NY9-β₂-ICI118-551 6PRZ-β₂-S-Alprenolol
5.88	Consensus	beta_off	Orthosteric Ligand	beta1_off beta2_off
5.88	Consensus	bombesin_off	Orthosteric Ligand	bb2_off
5.88	Consensus	d1_on	Orthosteric Ligand	7F0T-D₁-Dopamine-Gs/β1/γ2 7CKY-D₁-PW0464-Gs/β1/γ2 8IRR-D₁-Rotigotine-Gs/β1/γ2 7JV5-D₁-SKF81297-Gs/β1/γ2 7JVP-D₁-SKF83959-Gs/β1/γ2 7X2D-D₁-Tavapadon-Gs/β1/γ2 7CKX-D₁-A77636-Gs/β1/γ2 7JVQ-D₁-Apomorphine-Gs/β1/γ2 7CKW-D₁-Fenoldopam-Gs/β1/γ2
5.88	Consensus	d4_on	Orthosteric Ligand	8IRU-D₄-Rotigotine-chim(NtGi1-Gs-CtGi1)/β1/γ2
5.88	Consensus	gi_adrenergic	Orthosteric Ligand	7EJ0-α_2a-L-Norepinephrine-Go/β1/γ2 7EJK-α_2a-Oxymetazoline-Go/β1/γ2 7W7E-α_2a-PubChem 164946676-Go/β1/γ2 7W6P-α_2a-N-pyridin-4-ylisoquinolin-4-amine-Go/β1/γ2 7EJ8-α_2a-Brimonidine-Go/β1/γ2 6K42-α_2b-Dexmedetomidine-Gi1/β1/γ2 7EJA-α_2a-Dexmedetomidine-Go/β1/γ2 7S0F-β₁-Isoprenaline-Gi1/β1/γ2
5.88	Consensus	gs_amine	Orthosteric Ligand	gs_5ht gs_adrenergic gs_dopamine gs_histamine gs_trace-amine
5.88	Consensus	h1_off	Orthosteric Ligand	8X63-H₁-Mepyramine 3RZE-H₁-Cidoxepin 8X5Y-H₁-Astemizole
5.88	Consensus	lpa1_on	Orthosteric Ligand	7TD1-LPA₁-LPA-Gi1/β1/γ2 7YU3-LPA₁-ONO-0740556-Gi1/β1/γ2
5.88	Consensus	lpa1_on_gp	Orthosteric Ligand	7TD1-LPA₁-LPA-Gi1/β1/γ2 7YU3-LPA₁-ONO-0740556-Gi1/β1/γ2
5.88	Consensus	mc2_on	Orthosteric Ligand	8GY7-MC₂-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1
5.88	Consensus	mc2_on_gp	Orthosteric Ligand	8GY7-MC₂-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1
5.88	Consensus	nucleotide_on	Orthosteric Ligand	adenosine_on p2y_on
5.56	Single	2YDV	NECA	2YDV-A_2A-NECA
5.56	Single	3P0G	BI167107	3P0G-β₂-BI167107
5.56	Single	3PDS	Hydroxybenzylisoproterenol	3PDS-β₂-Hydroxybenzylisoproterenol
5.56	Single	3SN6	BI167107	3SN6-β₂-BI167107-Gs/β1/γ2
5.56	Single	3ZEV	Neurotensin	3ZEV-NTS₁-Neurotensin
5.56	Single	4BV0	Neurotensin	4BV0-NTS₁-Neurotensin
5.56	Single	4DJH	JDTic	4DJH-κ-JDTic
5.56	Single	4UHR	CGS21680	4UHR-A_2A-CGS21680
5.56	Single	4Z34	ONO-9780307	4Z34-LPA₁-ONO-9780307
5.56	Single	5A8E	7-Methylcyanopindolol	5A8E-β₁-7-Methylcyanopindolol-Na
5.56	Single	5D5A	S-Carazolol	5D5A-β₂-S-Carazolol
5.56	Single	5D5B	S-Carazolol	5D5B-β₂-S-Carazolol
5.56	Single	5G53	NECA	5G53-A_2A-NECA-Gs
5.56	Single	5TZR	MK8666	5TZR-FFA1-MK8666
5.56	Single	5V56	TC114	5V56-SMO-TC114
5.56	Single	5XRA	AM11542	5XRA-CB₁-AM11542
5.56	Single	6DDE	Damgo	6DDE-μ-Damgo-Gi1/β1/γ2
5.56	Single	6E59	L-760735	6E59-NK₁-L-760735
5.56	Single	6GT3	Imaradenant	6GT3-A_2A-Imaradenant-Na
5.56	Single	6H7J	Isoprenaline	6H7J-β₁-Isoprenaline
5.56	Single	6J20	Aprepitant	6J20-NK₁-Aprepitant
5.56	Single	6J21	Aprepitant	6J21-NK₁-Aprepitant
5.56	Single	6N48	BI167107	6N48-β₂-BI167107-PubChem 138454256
5.56	Single	6NI3	BI167107	6NI3-β₂-BI167107-Gs/β1/γ2
5.56	Single	6O3C	Cholesterol	6O3C-SMO-SAG21k-Cholesterol
5.56	Single	6RZ5	Zafirlukast	6RZ5-CysLT₁-Zafirlukast-Na
5.56	Single	6TQ7	SB-334867	6TQ7-OX₁-SB-334867
5.56	Single	6WGT	LSD	6WGT-5-HT_2A-LSD
5.56	Single	6Z8N	SRI-9829	6Z8N-NTS₁-SRI-9829
5.56	Single	7CKY	PW0464	7CKY-D₁-PW0464-Gs/β1/γ2
5.56	Single	7EW4	CYM5541	7EW4-S1P₃-CYM5541-Gi1/β1/γ2
5.56	Single	7EW7	SEW2871	7EW7-S1P₁-SEW2871-Gi1/β1/γ2
5.56	Single	7FEE	CP55940	7FEE-CB₁-CP55940-ZCZ011
5.56	Single	7JJO	Isoprenaline	7JJO-β₁-Isoprenaline-Gs/β1/γ2
5.56	Single	7JV5	SKF81297	7JV5-D₁-SKF81297-Gs/β1/γ2
5.56	Single	7JVP	SKF83959	7JVP-D₁-SKF83959-Gs/β1/γ2
5.56	Single	7L0P	Neurotensin	7L0P-NTS₁-Neurotensin-Gi1/β1/γ1
5.56	Single	7L0Q	Neurotensin	7L0Q-NTS₁-Neurotensin-Gi1/β1/γ1
5.56	Single	7P2L	4YI	7P2L-mGlu₅-4YI
5.56	Single	7PX4	PSB-2113	7PX4-A_2A-PSB-2113
5.56	Single	7T9N	PubChem 644078	7T9N-TSH-M22 Fab-PubChem 644078-Gs/β1/γ2
5.56	Single	7TD1	LPA	7TD1-LPA₁-LPA-Gi1/β1/γ2
5.56	Single	7TUY	GSK682753A	7TUY-GPR183-GSK682753A
5.56	Single	7U2L	PubChem 163201242	7U2L-μ-PubChem 163201242-Gi1/β1/γ2
5.56	Single	7W6P	N-pyridin-4-ylisoquinolin-4-amine	7W6P-α_2a-N-pyridin-4-ylisoquinolin-4-amine-Go/β1/γ2
5.56	Single	7W7E	PubChem 164946676	7W7E-α_2a-PubChem 164946676-Go/β1/γ2
5.56	Single	7WV9	CP55940	7WV9-CB₁-CP55940-ZCZ011-Gi2/β1/γ2
5.56	Single	7XAV	Lanreotide	7XAV-SST2-Lanreotide-Gi1/β1/γ2
5.56	Single	7XOW	Gastrin	7XOW-CCK_B-Gastrin-chim(NtGi1-Gq)/β1/γ2
5.56	Single	7XWO	Neurokinin-A	7XWO-NK₂-Neurokinin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
5.56	Single	7XY7	NECA	7XY7-A_2B-NECA-chim(NtGi1-Gs)/β1/γ2
5.56	Single	7Y67	C089 peptide	7Y67-C5a₁-C089 peptide-Gi1/β1/γ2
5.56	Single	7YU5	ONO-0740556	7YU5-LPA₁-ONO-0740556-Gi1/β1/γ2
5.56	Single	7YU7	ONO-0740556	7YU7-LPA₁-ONO-0740556-Gi1/β1/γ2
5.56	Single	8DCS	Cyanopindolol	8DCS-β₁-Cyanopindolol-Gs/β1/γ2
5.56	Single	8DZP	momSalB	8DZP-κ-momSalB-Gi1/β1/γ2
5.56	Single	8E0G	BU72	8E0G-μ-BU72
5.56	Single	8EFL	SR17018	8EFL-μ-SR17018-Gi1/β1/γ2
5.56	Single	8FMZ	Neurotensin/Neuromedin-N	8FMZ-NTS₁-Neurotensin/Neuromedin-N-chim(NtGi2L-Gs-CtGq)/β1/γ2
5.56	Single	8FN1	Neurotensin/Neuromedin-N	8FN1-NTS₁-Neurotensin/Neuromedin-N-chim(NtGi1-Go)/β1/γ2
5.56	Single	8HDO	BAY 60-6583	8HDO-A_2B-BAY 60-6583-Gs/β1/γ2
5.56	Single	8HPT	C5a anaphylatoxin C-terminal peptide	8HPT-C5a₁-C5a anaphylatoxin C-terminal peptide-Go/β1/γ2
5.56	Single	8HQC	C5a anaphylatoxin	8HQC-C5a₁-C5a anaphylatoxin-Go/β1/γ2
5.56	Single	8I9L	C3a anaphylatoxin	8I9L-C3a_B-C3a anaphylatoxin-Go/β1/γ2
5.56	Single	8ID3	9-Hydroxystearic acid	8ID3-FFA4-9-Hydroxystearic acid-Gi1/β1/γ2
5.56	Single	8ID6	Oleic acid	8ID6-FFA4-Oleic acid-Gi1/β1/γ2
5.56	Single	8IRR	Rotigotine	8IRR-D₁-Rotigotine-Gs/β1/γ2
5.56	Single	8IRU	Rotigotine	8IRU-D₄-Rotigotine-chim(NtGi1-Gs-CtGi1)/β1/γ2
5.56	Single	8IRV	Rotigotine	8IRV-D₅-Rotigotine-chim(NtGi1-Gs)/β1/γ2
5.56	Single	8JBG	Neurokinin-B	8JBG-NK₃-Neurokinin-B-chim(NtGi1-Gs-CtGq)/β1/γ2
5.56	Single	8JD5	BQI; HZE; PEF	8JD5-mGlu2; mGlu4-Glutamate-BQI; HZE; PEF-Gi1/β1/γ2
5.56	Single	8JXV	Clozapine	8JXV-H₄-Clozapine-Gi1/β1/γ2
5.56	Single	8JZP	C5A anaphylatoxin	8JZP-C5a₁-C5A anaphylatoxin-Go/β1/γ2
5.56	Single	8SZH	Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW	8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/β1/γ2
5.56	Single	8T1V	PubChem 118310209	8T1V-GPR6-PubChem 118310209-Na
5.56	Single	8UGW	PubChem 3086599	8UGW-A_2A-PubChem 3086599
5.56	Single	8VVF	JDTic	8VVF-κ-JDTic-Gi1/β1/γ2
5.56	Single	8X0B	VU0424465	8X0B-mGlu5; mGlu5-Quisqualate-VU0424465
5.56	Single	8X0F	VU0424465	8X0F-mGlu5; mGlu5-Quisqualate-VU0424465
5.56	Single	8X16	Piclidenoson	8X16-A_3A-Piclidenoson-Gi1/β1/γ2
5.56	Single	8XIP	Pasireotide	8XIP-SST1-Pasireotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
5.56	Single	8XVL	Zibotentan	8XVL-ET_A-Zibotentan
5.56	Single	8YH6	Namodenoson	8YH6-A_3A-Namodenoson-Gi1/β1/γ2
5.56	Single	9AYF	Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4	9AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/β1/γ2
5.56	Single	9B65	KCA	9B65-CB₁-KCA-Gi1/β1/γ2
5.56	Single	9IJD	Carazolol	9IJD-β₃-Carazolol-chim(NtGi1-Gs)/β1/γ2
5.56	Single	9IZG	NKP	9IZG-LPA₁-NKP-chim(NtGi1-Gs-CtGq)/β1/γ2
5.56	Consensus	a2_on	Orthosteric Ligand	a2b_on
5.56	Consensus	a2_on_gp	Orthosteric Ligand	a2b_on_gp
5.56	Consensus	a2b_on	Orthosteric Ligand	8HDP-A_2B-Adenosine-Gs/β1/γ2 7XY6-A_2B-BAY 60-6583-chim(NtGi1-Gs)/β1/γ2 7XY7-A_2B-NECA-chim(NtGi1-Gs)/β1/γ2 8HDO-A_2B-BAY 60-6583-Gs/β1/γ2
5.56	Consensus	a2b_on_gp	Orthosteric Ligand	8HDP-A_2B-Adenosine-Gs/β1/γ2 7XY6-A_2B-BAY 60-6583-chim(NtGi1-Gs)/β1/γ2 7XY7-A_2B-NECA-chim(NtGi1-Gs)/β1/γ2 8HDO-A_2B-BAY 60-6583-Gs/β1/γ2
5.56	Consensus	amine_on_gp	Orthosteric Ligand	5ht_on_gp adrenergic_on_gp dopamine_on_gp histamine_on_gp muscarinic_on_gp trace-amine_on_gp
5.56	Consensus	beta1_off	Orthosteric Ligand	2VT4-β₁-Cyanopindolol 2YCW-β₁-S-Carazolol 2YCZ-β₁-Iodocyanopindolol 5A8E-β₁-7-Methylcyanopindolol-Na 3ZPQ-β₁-4-(piperazin-1- yl)-1H-indole-Na 3ZPR-β₁-4-methyl-2-(piperazin-1-yl)-Na
5.56	Consensus	beta2_on	Orthosteric Ligand	7DHI-β₂-Salbutamol-Gs/β1/γ2 6NI3-β₂-BI167107-Gs/β1/γ2
5.56	Consensus	beta2_on_gp	Orthosteric Ligand	7DHI-β₂-Salbutamol-Gs/β1/γ2 6NI3-β₂-BI167107-Gs/β1/γ2
5.56	Consensus	class-a_off	Orthosteric Ligand	sensory_off alicarboxylic_off amine_off lipid_off nucleotide_off peptide_off protein_off
5.56	Consensus	cyslt1_off	Orthosteric Ligand	6RZ5-CysLT₁-Zafirlukast-Na 6RZ4-CysLT₁-Pranlukast-Na
5.56	Consensus	d1_on_gp	Orthosteric Ligand	7F0T-D₁-Dopamine-Gs/β1/γ2 7CKY-D₁-PW0464-Gs/β1/γ2 8IRR-D₁-Rotigotine-Gs/β1/γ2 7JV5-D₁-SKF81297-Gs/β1/γ2 7JVP-D₁-SKF83959-Gs/β1/γ2 7X2D-D₁-Tavapadon-Gs/β1/γ2 7CKX-D₁-A77636-Gs/β1/γ2 7JVQ-D₁-Apomorphine-Gs/β1/γ2 7CKW-D₁-Fenoldopam-Gs/β1/γ2
5.56	Consensus	d4_on_gp	Orthosteric Ligand	8IRU-D₄-Rotigotine-chim(NtGi1-Gs-CtGi1)/β1/γ2
5.56	Consensus	d5_on_gp	Orthosteric Ligand	8IRV-D₅-Rotigotine-chim(NtGi1-Gs)/β1/γ2
5.56	Consensus	ffa2_on	Orthosteric Ligand	8J22-FFA2-TUG-1375-Gi1/β1/γ2
5.56	Consensus	gi_5ht	Orthosteric Ligand	8FYT-5-HT_1A-LSD-Gi1/β1/γ1 7UM7-5-HT_5A-Methylergometrine-chim(NtGi1-Go)/β1/γ2 8UGY-5-HT_1E-Mianserin-Gi1/β1/γ1 8W8B-5-HT_1A-SEP-363856-Gi1/β1/γ2 7E2Y-5-HT_1A-Serotonin-Gi1/β1/γ2 7E32-5-HT_1D-Serotonin-Gi1/β1/γ2 7XTA-5-HT₄-Serotonin-Gi1/β1/γ2 8UH3-5-HT_1E-Setiptiline-Gi1/β1/γ1 8JSP-5-HT_1A-Ulotaront-Gi1/β1/γ2 8FYL-5-HT_1A-Vilazodone-Gi1/β1/γ1 8JT6-5-HT_1A-(R)-IHCH-7179-Gi1/β1/γ2 8FYE-5-HT_1A-4-F,5-MeO-PyrT-Gi1/β1/γ1 7X5H-5-HT_5A-5-CT-Gi1/β1/γ2 8FY8-5-HT_1A-5-MeO-DMT-Gi1/β1/γ1 7E2Z-5-HT_1A-Aripiprazole-Gi1/β1/γ2 7E33-5-HT_1E-BRL-54443-Gi1/β1/γ2 8FYX-5-HT_1A-Buspirone-Gi1/β1/γ1 7EXD-5-HT_1F-Lasmiditan-Gi1/β1/γ2 7UM6-5-HT_5A-Lisuride-chim(NtGi1-Go)/β1/γ2
5.56	Consensus	gi_dopamine	Orthosteric Ligand	7JVR-D₂-Bromoergocryptine-Gi1/β1/γ2 7CMV-D₃-PD128907-Gi1/β1/γ2 7CMU-D₃-Pramipexole-Gi1/β1/γ2 8IRS-D₂-Rotigotine-Gi1/β1/γ2 8IRT-D₃-Rotigotine-Gi1/β1/γ2
5.56	Consensus	gi_lpa	Orthosteric Ligand	7TD1-LPA₁-LPA-Gi1/β1/γ2 7YU3-LPA₁-ONO-0740556-Gi1/β1/γ2
5.56	Consensus	gs_adenosine	Orthosteric Ligand	8HDP-A_2B-Adenosine-Gs/β1/γ2 8HDO-A_2B-BAY 60-6583-Gs/β1/γ2 7XY7-A_2B-NECA-chim(NtGi1-Gs)/β1/γ2 7XY6-A_2B-BAY 60-6583-chim(NtGi1-Gs)/β1/γ2
5.56	Consensus	gs_dopamine	Orthosteric Ligand	7F0T-D₁-Dopamine-Gs/β1/γ2 7CKW-D₁-Fenoldopam-Gs/β1/γ2 7CKY-D₁-PW0464-Gs/β1/γ2 8IRV-D₅-Rotigotine-chim(NtGi1-Gs)/β1/γ2 8IRR-D₁-Rotigotine-Gs/β1/γ2 7JV5-D₁-SKF81297-Gs/β1/γ2 7JVP-D₁-SKF83959-Gs/β1/γ2 7X2D-D₁-Tavapadon-Gs/β1/γ2 7CKX-D₁-A77636-Gs/β1/γ2 7JVQ-D₁-Apomorphine-Gs/β1/γ2
5.56	Consensus	gs_nucleotide	Orthosteric Ligand	gs_adenosine
5.56	Consensus	kop_off	Orthosteric Ligand	4DJH-κ-JDTic
5.56	Consensus	lpa_on	Orthosteric Ligand	lpa1_on
5.56	Consensus	lpa_on_gp	Orthosteric Ligand	lpa1_on_gp
5.56	Consensus	motilin_on	Orthosteric Ligand	8IBU-Motilin-Erythromycin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
5.56	Consensus	neurotensin_on	Orthosteric Ligand	nts1_on
5.56	Consensus	nk2_on_gp	Orthosteric Ligand	7XWO-NK₂-Neurokinin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
5.56	Consensus	nts1_on	Orthosteric Ligand	6OSA-NTS₁-JMV449-Gi1/β1/γ2 7L0S-NTS₁-Neurotensin-Gi1/β1/γ1
5.56	Consensus	tachykinin_off	Orthosteric Ligand	nk1_off
5.26	Single	2YCX	Cyanopindolol	2YCX-β₁-Cyanopindolol
5.26	Single	3D4S	Timolol	3D4S-β₂-Timolol
5.26	Single	4AMI	Bucindolol	4AMI-β₁-Bucindolol
5.26	Single	4GRV	Neurotensin-(8-13)	4GRV-NTS₁-Neurotensin-(8-13)
5.26	Single	4LDE	BI167107	4LDE-β₂-BI167107
5.26	Single	4N4W	SANT-1	4N4W-SMO-SANT-1
5.26	Single	4OR2	FITM	4OR2-mGlu1; mGlu1-FITM
5.26	Single	4PY0	2MeSATP	4PY0-P2Y₁₂-2MeSATP
5.26	Single	4RWA	DIPP-NH2	4RWA-δ-DIPP-NH2
5.26	Single	4XEE	Neurotensin	4XEE-NTS₁-Neurotensin
5.26	Single	4XES	Neurotensin	4XES-NTS₁-Neurotensin
5.26	Single	4Z36	ONO-3080573	4Z36-LPA₁-ONO-3080573
5.26	Single	5F8U	Cyanopindolol	5F8U-β₁-Cyanopindolol
5.26	Single	5TZY	MK8666; PubChem 127053597	5TZY-FFA1-MK8666; PubChem 127053597
5.26	Single	6H7O	Cyanopindolol	6H7O-β₁-Cyanopindolol
5.26	Single	6KQI	CP55940	6KQI-CB₁-CP55940-Org27569
5.26	Single	6MXT	Salmeterol	6MXT-β₂-Salmeterol
5.26	Single	6OSA	JMV449	6OSA-NTS₁-JMV449-Gi1/β1/γ2
5.26	Single	6VMS	Bromoergocryptine	6VMS-D₂-Bromoergocryptine-Gi1/β1/γ2
5.26	Single	6W2Y	PubChem 23727970	6W2Y-GABAB1; GABAB1-PubChem 5311042-PubChem 23727970
5.26	Single	6XBL	Cholesterol	6XBL-SMO-SAG-Cholesterol-Gi1/β1/γ2
5.26	Single	7EO4	BAF312	7EO4-S1P₁-BAF312-Gi1/β1/γ2
5.26	Single	7EPE	NAM563	7EPE-mGlu2; mGlu2-NAM563
5.26	Single	7EVY	Siponimod	7EVY-S1P₁-Siponimod-Gi1/β1/γ2
5.26	Single	7EW2	Fingolimod	7EW2-S1P₃-Fingolimod-Gi1/β1/γ2
5.26	Single	7L0S	Neurotensin	7L0S-NTS₁-Neurotensin-Gi1/β1/γ1
5.26	Single	7L1U	Orexin	7L1U-OX₂-Orexin-chim(NtGi1-Gs-CtGq)/β1/γ2
5.26	Single	7L1V	PubChem 155491009	7L1V-OX₂-PubChem 155491009-chim(NtGi1-Gs-CtGq)/β1/γ2
5.26	Single	7MTR	ADX55164	7MTR-mGlu2; mGlu2-Glutamate-ADX55164
5.26	Single	7SUS	PubChem 122701908	7SUS-Apelin-PubChem 122701908
5.26	Single	7W0L	PubChem 122701908	7W0L-Apelin-PubChem 122701908-Gi1/β1/γ2
5.26	Single	7XMT	J-2156	7XMT-SST4-J-2156-Gi1/β1/γ2
5.26	Single	7Y66	BM213	7Y66-C5a₁-BM213-Gi1/β1/γ2
5.26	Single	7YIT	Nalfurafine	7YIT-κ-Nalfurafine
5.26	Single	7YMJ	Tamsulosin	7YMJ-Alpha1A-Tamsulosin
5.26	Single	8E9W	2-Deoxycytidine	8E9W-M₃-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/β1/γ2
5.26	Single	8FYE	4-F,5-MeO-PyrT	8FYE-5-HT_1A-4-F,5-MeO-PyrT-Gi1/β1/γ1
5.26	Single	8H0Q	Gastrin Releasing Peptide	8H0Q-BB₂-Gastrin Releasing Peptide-chim(NtGi1-Gs-CtGq)/β1/γ2
5.26	Single	8HK2	C3a anaphylatoxin	8HK2-C3a_B-C3a anaphylatoxin-Gi1/β1/γ2
5.26	Single	8I9A	EP54	8I9A-C3a_B-EP54-chim(NtGi1-Gs-CtGq)/β1/γ2
5.26	Single	8IA8	E7 peptide	8IA8-C3a_B-E7 peptide-Gi1/β1/γ2
5.26	Single	8IBU	Erythromycin-A	8IBU-Motilin-Erythromycin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
5.26	Single	8IRS	Rotigotine	8IRS-D₂-Rotigotine-Gi1/β1/γ2
5.26	Single	8JD3	HZR; PEF	8JD3-mGlu2; mGlu3-Glutamate-HZR; PEF-Gi1/β1/γ2
5.26	Single	8JJ8	Formoterol	8JJ8-β₂-Formoterol
5.26	Single	8JJL	Olodaterol	8JJL-β₂-Olodaterol
5.26	Single	8JJP	Chemerin	8JJP-CML2-Chemerin-Gi1/β1/γ2
5.26	Single	8JPB	Neurotensin-(8-13)	8JPB-NTS₁-Neurotensin-(8-13)-PubChem 118610427; GDP; Mg-Gq; GRK2
5.26	Single	8JWY	2-118	8JWY-A_2A-2-118
5.26	Single	8JWZ	AB928	8JWZ-A_2A-AB928-Na
5.26	Single	8SZH	Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW	8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/β1/γ2
5.26	Single	8T3Q	Docosa-4,7,10,13,16,19-Hexaenoic acid	8T3Q-FFA4-Docosa-4,7,10,13,16,19-Hexaenoic acid-chim(NtGi2L-Gs-CtGq)/β1/γ2
5.26	Single	8U26	Protachykinin-1	8U26-NK₁-Protachykinin-1-Gs/β1/γ2
5.26	Single	8W1V	PubChem 171716265	8W1V-β₂-PubChem 171716265
5.26	Single	8XQJ	JN241	8XQJ-Apelin-JN241
5.26	Single	9GYO	P395	9GYO-GPBA-P395-chim(NtGi1-Gs)/β1/γ2
5.26	Single	9IZH	LPA	9IZH-LPA₁-LPA-chim(NtGi2-G13)/β1/γ2
5.26	Single	9L3W	Retinoic acid receptor responder protein 2	9L3W-CML1-Retinoic acid receptor responder protein 2-Gi1/β1/γ2
5.26	Single	9MQL	Isoquinuclidine	9MQL-κ-Isoquinuclidine
5.26	Consensus	alpha1_off	Orthosteric Ligand	alpha1a_off
5.26	Consensus	alpha1a_off	Orthosteric Ligand	7YMJ-Alpha1A-Tamsulosin
5.26	Consensus	beta_on	Orthosteric Ligand	beta1_on beta2_on beta3_on
5.26	Consensus	beta_on_gp	Orthosteric Ligand	beta1_on_gp beta2_on_gp beta3_on_gp
5.26	Consensus	c3a_on	Orthosteric Ligand	8HK2-C3a_B-C3a anaphylatoxin-Gi1/β1/γ2 8IA8-C3a_B-E7 peptide-Gi1/β1/γ2
5.26	Consensus	cb1_on	Orthosteric Ligand	6KPG-CB₁-AM841-Gi1/β1/γ2 8K8J-CB₁-Fenofibrate-chim(Gs-CtGq)/β1/γ2
5.26	Consensus	ccr8_on	Orthosteric Ligand	8KFX-CCR8-LMD-009-Gi1/β1/γ2 8KFY-CCR8-ZK-756326-Gi1/β1/γ2 8U1U-CCR8-CCL1-Gi1/β1/γ2
5.26	Consensus	d2_on_gp	Orthosteric Ligand	7JVR-D₂-Bromoergocryptine-Gi1/β1/γ2 8IRS-D₂-Rotigotine-Gi1/β1/γ2
5.26	Consensus	ffa2_on_gp	Orthosteric Ligand	8J22-FFA2-TUG-1375-Gi1/β1/γ2
5.26	Consensus	gi_amine	Orthosteric Ligand	gi_5ht gi_muscarinic gi_adrenergic gi_dopamine gi_histamine
5.26	Consensus	gi_lipid	Orthosteric Ligand	gi_cannabinoid gi_ffa gi_leukotriene gi_lpa gi_s1p
5.26	Consensus	gi_neurotensin	Orthosteric Ligand	6OSA-NTS₁-JMV449-Gi1/β1/γ2 7L0S-NTS₁-Neurotensin-Gi1/β1/γ1
5.26	Consensus	kop_on	Orthosteric Ligand	8F7W-κ-Dynorphin-Gi1/β1/γ2 8DZS-κ-GR89,696-chim(NtGi2-Gz)/β1/γ2 8DZP-κ-momSalB-Gi1/β1/γ2
5.26	Consensus	leukotriene_off	Orthosteric Ligand	blt_off cyslt_off
5.26	Consensus	lipid_offon	Orthosteric Ligand	lipid_off lipid_on
5.26	Consensus	lipid_offon_gp	Orthosteric Ligand	lipid_on_gp lipid_off
5.26	Consensus	lpa1_off	Orthosteric Ligand	4Z36-LPA₁-ONO-3080573 4Z35-LPA₁-ONO-9910539 4Z34-LPA₁-ONO-9780307
5.26	Consensus	lpa_off	Orthosteric Ligand	lpa1_off
5.26	Consensus	lpl_off	Orthosteric Ligand	s1p_off lpa_off
5.26	Consensus	mop_on	Orthosteric Ligand	8F7R-μ-Endomorphin-Gi1/β1/γ2 8EF5-μ-Fentanyl-Gi1/β1/γ2 7SCG-μ-FH210-Gi1/β1/γ2 7T2H-μ-Lofentanil-Gi1/β1/γ2 7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2 8EF6-μ-Morphine-Gi1/β1/γ2 8EFB-μ-Oliceridine-Gi1/β1/γ2 7U2L-μ-PubChem 163201242-Gi1/β1/γ2 8EFO-μ-PZM21-Gi1/β1/γ2 8EFL-μ-SR17018-Gi1/β1/γ2 8F7Q-μ-β-Endorphin-Gi1/β1/γ2 7U2K-μ-C6-guano-Gi1/β1/γ2 8EFQ-μ-Damgo-Gi1/β1/γ2
5.26	Consensus	mop_on_gp	Orthosteric Ligand	8F7R-μ-Endomorphin-Gi1/β1/γ2 8EF5-μ-Fentanyl-Gi1/β1/γ2 7SCG-μ-FH210-Gi1/β1/γ2 7T2H-μ-Lofentanil-Gi1/β1/γ2 7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2 8EF6-μ-Morphine-Gi1/β1/γ2 8EFB-μ-Oliceridine-Gi1/β1/γ2 7U2L-μ-PubChem 163201242-Gi1/β1/γ2 8EFO-μ-PZM21-Gi1/β1/γ2 8EFL-μ-SR17018-Gi1/β1/γ2 8F7Q-μ-β-Endorphin-Gi1/β1/γ2 7U2K-μ-C6-guano-Gi1/β1/γ2 8EFQ-μ-Damgo-Gi1/β1/γ2
5.26	Consensus	motilin_on_gp	Orthosteric Ligand	8IBU-Motilin-Erythromycin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
5.26	Consensus	neurotensin_on_gp	Orthosteric Ligand	nts1_on_gp
5.26	Consensus	nk1_off	Orthosteric Ligand	6HLP-NK₁-Netupitant 6HLO-NK₁-Aprepitant 6HLL-NK₁-CP99994 6E59-NK₁-L-760735
5.26	Consensus	nts1_on_gp	Orthosteric Ligand	6OSA-NTS₁-JMV449-Gi1/β1/γ2 7L0S-NTS₁-Neurotensin-Gi1/β1/γ1
5.26	Consensus	opioid_off	Orthosteric Ligand	mop_off nop_off dop_off kop_off
5.26	Consensus	orexin_on	Orthosteric Ligand	ox2_on
5.26	Consensus	s1p1_on	Orthosteric Ligand	7VIE-S1P₁-S1P-Gi1/β1/γ2 7VIF-S1P₁-S-FTY720-P-Gi1/β1/γ2 7VIG-S1P₁-CBP-307-Gi1/β1/γ2 7EVY-S1P₁-Siponimod-Gi1/β1/γ2 7EVZ-S1P₁-Cenerimod-Gi1/β1/γ2 7EW0-S1P₁-Ozanimod-Gi1/β1/γ2 7EW7-S1P₁-SEW2871-Gi1/β1/γ2
5.26	Consensus	s1p1_on_gp	Orthosteric Ligand	7VIE-S1P₁-S1P-Gi1/β1/γ2 7VIF-S1P₁-S-FTY720-P-Gi1/β1/γ2 7VIG-S1P₁-CBP-307-Gi1/β1/γ2 7EVY-S1P₁-Siponimod-Gi1/β1/γ2 7EVZ-S1P₁-Cenerimod-Gi1/β1/γ2 7EW0-S1P₁-Ozanimod-Gi1/β1/γ2 7EW7-S1P₁-SEW2871-Gi1/β1/γ2
5.26	Consensus	s1p3_on	Orthosteric Ligand	7EW3-S1P₃-S1P-Gi1/β1/γ2 7EW4-S1P₃-CYM5541-Gi1/β1/γ2 7EW2-S1P₃-Fingolimod-Gi1/β1/γ2
5.00	Single	2YCZ	Iodocyanopindolol	2YCZ-β₁-Iodocyanopindolol
5.00	Single	4BUO	Neurotensin	4BUO-NTS₁-Neurotensin
5.00	Single	4BVN	Cyanopindolol	4BVN-β₁-Cyanopindolol-Na
5.00	Single	4OR2	FITM	4OR2-mGlu1; mGlu1-FITM
5.00	Single	4Z35	ONO-9910539	4Z35-LPA₁-ONO-9910539
5.00	Single	5X93	K-8794	5X93-ET_B-K-8794
5.00	Single	6BQG	Ergotamine	6BQG-5-HT_2C-Ergotamine
5.00	Single	6DDF	Damgo	6DDF-μ-Damgo-Gi1/β1/γ2
5.00	Single	6H7L	Dobutamine	6H7L-β₁-Dobutamine
5.00	Single	6IBL	Arformoterol	6IBL-β₁-Arformoterol
5.00	Single	6K1Q	IRL2500	6K1Q-ET_B-IRL2500
5.00	Single	6TKO	Arformoterol	6TKO-β₁-Arformoterol-Arrestin2
5.00	Single	6UP7	Neurotensin	6UP7-NTS₁-Neurotensin-Arrestin2
5.00	Single	7EVZ	Cenerimod	7EVZ-S1P₁-Cenerimod-Gi1/β1/γ2
5.00	Single	7EW0	Ozanimod	7EW0-S1P₁-Ozanimod-Gi1/β1/γ2
5.00	Single	7EZC	UKA	7EZC-A_2A-UKA
5.00	Single	7EZH	Cholecystokinin-8	7EZH-CCK_A-Cholecystokinin-8-Gi1/β1/γ2
5.00	Single	7EZM	Cholecystokinin-8	7EZM-CCK_A-Cholecystokinin-8-chim(NtGsL-Gq)/β1/γ2
5.00	Single	7MBY	Cholecystokinin-8	7MBY-CCK_A-Cholecystokinin-8-chim(NtGi1L-Gs-CtGq)/β1/γ2
5.00	Single	7MTS	ADX55164	7MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/β1/γ2
5.00	Single	7P00	Substance-P	7P00-NK₁-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
5.00	Single	7PIU	Setmelanotide	7PIU-MC₄-Setmelanotide-Gs/β1/γ2
5.00	Single	7QVM	Oxytocin	7QVM-OT-Oxytocin-chim(NtGi1-Go-CtGq)/β1/γ2
5.00	Single	7UM4	AS2674723	7UM4-5-HT_5A-AS2674723
5.00	Single	7WVV	fMLFII	7WVV-FPR2-ALX-fMLFII-Gi2/β1/γ2
5.00	Single	7X1U	TRH	7X1U-TRH-TRH-chim(NtGi2L-Gs-CtGq)/β1/γ2
5.00	Single	7X2D	Tavapadon	7X2D-D₁-Tavapadon-Gs/β1/γ2
5.00	Single	7YU8	ONO-0740556	7YU8-LPA₁-ONO-0740556-Gi1/β1/γ2
5.00	Single	8E9X	2-Deoxycytidine	8E9X-M₄-2-Deoxycytidine-chim(NtGi1-Go)/β1/γ2
5.00	Single	8E9Y	Clozapine-N-oxide	8E9Y-M₃-Clozapine-N-oxide-chim(NtGi2L-Gs-CtGq)/β1/γ2
5.00	Single	8FN0	Neurotensin/Neuromedin-N	8FN0-NTS₁-Neurotensin/Neuromedin-N-PubChem 118610427-chim(NtGi1-Go)/β1/γ2
5.00	Single	8FX5	Xanomeline	8FX5-M₄-Xanomeline-Xanomeline-Gi1/β1/γ2
5.00	Single	8GUT	LEI-102	8GUT-CB₂-LEI-102-Gi1/β1/γ2
5.00	Single	8GY7	Corticotropin	8GY7-MC₂-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1
5.00	Single	8I95	EP54	8I95-C3a_B-EP54-Go/β1/γ2
5.00	Single	8ID8	TUG-891	8ID8-FFA4-TUG-891-Gi1/β1/γ2
5.00	Single	8IYS	TUG-891	8IYS-FFA4-TUG-891-GDP-chim(NtGi1L-Gq)/β1/γ2
5.00	Single	8JPF	Neurotensin	8JPF-NTS₁-Neurotensin-PubChem 118610427
5.00	Single	8T3O	TUG-891	8T3O-FFA4-TUG-891-2Y5-chim(NtGi2L-Gs-CtGq)/β1/γ2
5.00	Single	8WRZ	PubChem 102336704	8WRZ-CB₁-PubChem 102336704-Arrestin2
5.00	Single	8XGS	Metastin	8XGS-Kiss1-Metastin-chim(NtGi1-Gq)/β1/γ2
5.00	Single	8XIO	L797591	8XIO-SST1-L797591-chim(NtGi1-Gs-CtGi1)/β1/γ2
5.00	Single	8XVJ	Macitentan	8XVJ-ET_A-Macitentan
5.00	Single	9GE3	Lysophosphatidylinositol	9GE3-GPR55-Lysophosphatidylinositol-chim(CtGi1-G13)/β1/γ2
5.00	Single	9IZF	NKP	9IZF-LPA₁-NKP-Gi1/β1/γ2
5.00	Consensus	beta1_on	Orthosteric Ligand	8DCR-β₁-Dobutamine-Gs/β1/γ2 7S0F-β₁-Isoprenaline-Gi1/β1/γ2
5.00	Consensus	beta1_on_gp	Orthosteric Ligand	8DCR-β₁-Dobutamine-Gs/β1/γ2 7S0F-β₁-Isoprenaline-Gi1/β1/γ2
5.00	Consensus	c3a_on_gp	Orthosteric Ligand	8HK2-C3a_B-C3a anaphylatoxin-Gi1/β1/γ2 8IA8-C3a_B-E7 peptide-Gi1/β1/γ2
5.00	Consensus	cb1_on_gp	Orthosteric Ligand	6KPG-CB₁-AM841-Gi1/β1/γ2 8K8J-CB₁-Fenofibrate-chim(Gs-CtGq)/β1/γ2
5.00	Consensus	cck_on	Orthosteric Ligand	ccka_on cckb_on
5.00	Consensus	cck_on_gp	Orthosteric Ligand	ccka_on_gp cckb_on_gp
5.00	Consensus	ccka_on	Orthosteric Ligand	7EZH-CCK_A-Cholecystokinin-8-Gi1/β1/γ2
5.00	Consensus	ccka_on_gp	Orthosteric Ligand	7EZH-CCK_A-Cholecystokinin-8-Gi1/β1/γ2
5.00	Consensus	endothelin_off	Orthosteric Ligand	etb_off
5.00	Consensus	etb_off	Orthosteric Ligand	5X93-ET_B-K-8794 5XPR-ET_B-Bosentan 6K1Q-ET_B-IRL2500
5.00	Consensus	gi_s1p	Orthosteric Ligand	7VIE-S1P₁-S1P-Gi1/β1/γ2 7EW3-S1P₃-S1P-Gi1/β1/γ2 7EVY-S1P₁-Siponimod-Gi1/β1/γ2 7EW1-S1P₅-Siponimod-Gi1/β1/γ2 7VIF-S1P₁-S-FTY720-P-Gi1/β1/γ2 7VIG-S1P₁-CBP-307-Gi1/β1/γ2 7EVZ-S1P₁-Cenerimod-Gi1/β1/γ2 7EW4-S1P₃-CYM5541-Gi1/β1/γ2 7EW2-S1P₃-Fingolimod-Gi1/β1/γ2 7EW0-S1P₁-Ozanimod-Gi1/β1/γ2 7EW7-S1P₁-SEW2871-Gi1/β1/γ2
5.00	Consensus	kop_on_gp	Orthosteric Ligand	8F7W-κ-Dynorphin-Gi1/β1/γ2 8DZS-κ-GR89,696-chim(NtGi2-Gz)/β1/γ2 8DZP-κ-momSalB-Gi1/β1/γ2
5.00	Consensus	nk1_on	Orthosteric Ligand	7P00-NK₁-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
5.00	Consensus	nk1_on_gp	Orthosteric Ligand	7P00-NK₁-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
5.00	Consensus	nk2_on	Orthosteric Ligand	7XWO-NK₂-Neurokinin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
5.00	Consensus	nucleotide_on_gp	Orthosteric Ligand	adenosine_on_gp p2y_on_gp
5.00	Consensus	orexin_on_gp	Orthosteric Ligand	ox2_on_gp
5.00	Consensus	peptide_off	Orthosteric Ligand	cck_off angiotensin_off bombesin_off endothelin_off ghrelin_off npy_off opioid_off orexin_off somatostatin_off tachykinin_off vasop-oxy_off neurotensin_off
4.76	Single	3NY9	ICI118-551	3NY9-β₂-ICI118-551
4.76	Single	4UG2	CGS21680	4UG2-A_2A-CGS21680
4.76	Single	5VBL	Apelin mimetic peptide agonist	5VBL-Apelin-Apelin mimetic peptide agonist
4.76	Single	5WF6	UK-432097	5WF6-A_2A-UK-432097
4.76	Single	5ZTY	AM10257	5ZTY-CB₂-AM10257
4.76	Single	6C1Q	PMX53	6C1Q-C5a₁-PMX53-NDT9513727
4.76	Single	6G79	Donitriptan	6G79-5-HT_1B-Donitriptan-Go/β1/γ2
4.76	Single	6OS9	JMV449	6OS9-NTS₁-JMV449-Gi1/β1/γ2
4.76	Single	6PT3	DPI-287	6PT3-δ-DPI-287
4.76	Single	6W2Y	PubChem 23727970	6W2Y-GABAB1; GABAB1-PubChem 5311042-PubChem 23727970
4.76	Single	6XBJ	Cholesterol	6XBJ-SMO-Cholesterol-Gi1/β1/γ2
4.76	Single	7AUE	Setmelanotide	7AUE-MC₄-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2
4.76	Single	7F2O	Bradykinin	7F2O-BK₂-Bradykinin-chim(NtGi1-Gs-CtGq)/β1/γ2
4.76	Single	7F8W	Gastrin-17	7F8W-CCK_B-Gastrin-17-chim(NtGsL-Gq)/β1/γ2
4.76	Single	7RKN	Fractalkine	7RKN-US28-Fractalkine-Gi1/β1/γ2
4.76	Single	7RMG	Substance-P	7RMG-NK₁-Substance-P-chim(Gs-CtGq)/β1/γ2
4.76	Single	7RMH	Substance-P	7RMH-NK₁-Substance-P-Gs/β1/γ2
4.76	Single	7T11	Octreotide	7T11-SST2-Octreotide-Gi3/β1/γ2
4.76	Single	7XN9	L-054,522	7XN9-SST2-L-054,522
4.76	Single	7XY6	BAY 60-6583	7XY6-A_2B-BAY 60-6583-chim(NtGi1-Gs)/β1/γ2
4.76	Single	7Y1F	Dynorphin	7Y1F-κ-Dynorphin-Gi1/β1/γ2
4.76	Single	7YAE	Octreotide	7YAE-SST2-Octreotide-Gi1/β1/γ2
4.76	Single	8F7R	Endomorphin	8F7R-μ-Endomorphin-Gi1/β1/γ2
4.76	Single	8IA7	Cholecystokinin-8	8IA7-CCK_B-Cholecystokinin-8-chim(NtGi1L-Gq)/β1/γ2
4.76	Single	8IEI	A1LYA	8IEI-GPR156-A1LYA
4.76	Single	8JBF	Senktide	8JBF-NK₃-Senktide-chim(NtGi1-Gs-CtGq)/β1/γ2
4.76	Single	8QJ2	pN162	8QJ2-MC₄-pN162-Gs
4.76	Single	8X3L	XWD	8X3L-CB₂-XWD-Gi1/β1/γ2
4.76	Single	8X5Y	Astemizole	8X5Y-H₁-Astemizole
4.76	Single	8XQJ	JN241	8XQJ-Apelin-JN241
4.76	Single	8Z74	Agonistic antibody	8Z74-Apelin-Agonistic antibody
4.76	Single	8Z74	Agonistic antibody	8Z74-Apelin-Agonistic antibody
4.76	Consensus	cb2_off	Orthosteric Ligand	5ZTY-CB₂-AM10257
4.76	Consensus	dop_on	Orthosteric Ligand	8F7S-δ-Deltorphin-Gi1/β1/γ2
4.76	Consensus	gq_cck	Orthosteric Ligand	8IA7-CCK_B-Cholecystokinin-8-chim(NtGi1L-Gq)/β1/γ2 7XOW-CCK_B-Gastrin-chim(NtGi1-Gq)/β1/γ2 7EZM-CCK_A-Cholecystokinin-8-chim(NtGsL-Gq)/β1/γ2 7F8W-CCK_B-Gastrin-17-chim(NtGsL-Gq)/β1/γ2
4.76	Consensus	kiss1_on	Orthosteric Ligand	8ZJD-Kiss1-Kisspeptin-10-chim(NtGi1-Gq)/β1/γ1
4.76	Consensus	kisspeptin_on	Orthosteric Ligand	kiss1_on
4.76	Consensus	nmur1_on	Orthosteric Ligand	7W53-NMUR1-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
4.76	Consensus	ox2_on	Orthosteric Ligand	7L1V-OX₂-PubChem 155491009-chim(NtGi1-Gs-CtGq)/β1/γ2 7SQO-OX₂-TAK-925-Gi1/β1/γ2 7L1U-OX₂-Orexin-chim(NtGi1-Gs-CtGq)/β1/γ2
4.76	Consensus	ox2_on_gp	Orthosteric Ligand	7L1V-OX₂-PubChem 155491009-chim(NtGi1-Gs-CtGq)/β1/γ2 7SQO-OX₂-TAK-925-Gi1/β1/γ2 7L1U-OX₂-Orexin-chim(NtGi1-Gs-CtGq)/β1/γ2
4.76	Consensus	s1p_on	Orthosteric Ligand	s1p1_on s1p3_on s1p5_on
4.76	Consensus	s1p_on_gp	Orthosteric Ligand	s1p1_on_gp s1p3_on_gp s1p5_on_gp
4.76	Consensus	sst2_on	Orthosteric Ligand	7WIC-SST2-Somatostatin-14-Gi1/β1/γ2 7WIG-SST2-L-054,264-Gi1/β1/γ2 7YAE-SST2-Octreotide-Gi1/β1/γ2 7YAC-SST2-Paltusotine-Gi1/β1/γ2
4.76	Consensus	sst2_on_gp	Orthosteric Ligand	7WIC-SST2-Somatostatin-14-Gi1/β1/γ2 7WIG-SST2-L-054,264-Gi1/β1/γ2 7YAE-SST2-Octreotide-Gi1/β1/γ2 7YAC-SST2-Paltusotine-Gi1/β1/γ2
4.55	Single	4AMJ	S-Carvedilol	4AMJ-β₁-S-Carvedilol
4.55	Single	4IAR	Ergotamine	4IAR-5-HT_1B-Ergotamine
4.55	Single	4IB4	Ergotamine	4IB4-5-HT_2B-Ergotamine
4.55	Single	6WIV	PubChem 52923113; PubChem 52924645	6WIV-GABA_B1, GABA_B2-PubChem 52923113; PubChem 52924645
4.55	Single	7F4I	SHU9119	7F4I-MC₁-SHU9119-chim(NtGi1-Gs)/β1/γ2
4.55	Single	7F8X	NN9056	7F8X-CCK_A-NN9056
4.55	Single	7L0R	Neurotensin	7L0R-NTS₁-Neurotensin-Gi1/β1/γ1
4.55	Single	7NA7	Ghrelin-27	7NA7-Ghrelin-Ghrelin-27-Gi1/β1/γ2
4.55	Single	7TD4	Siponimod	7TD4-S1P₁-Siponimod-Gi1/β1/γ2
4.55	Single	7W0P	Elabela	7W0P-Apelin-Elabela-Gi1/β1/γ2
4.55	Single	7W2Z	Ghrelin	7W2Z-Ghrelin-Ghrelin-Go/β1/γ2
4.55	Single	7W53	Neuromedin-U-25	7W53-NMUR1-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
4.55	Single	7WKD	TRH	7WKD-TRH-TRH-chim(NtGi1-Gs-CtGq)/β1/γ2
4.55	Single	7XMR	Somatostatin-14	7XMR-SST2-Somatostatin-14-Gi1/β1/γ2
4.55	Single	8DCR	Dobutamine	8DCR-β₁-Dobutamine-Gs/β1/γ2
4.55	Single	8F7X	Nociceptin	8F7X-NOP-Nociceptin-Gi1/β1/γ2
4.55	Single	8FYL	Vilazodone	8FYL-5-HT_1A-Vilazodone-Gi1/β1/γ1
4.55	Single	8GHV	AMG315	8GHV-CB₁-AMG315-Gi1/β1/γ2
4.55	Single	8IEB	A1LYA	8IEB-GPR156-A1LYA
4.55	Single	8IEI	A1LYA	8IEI-GPR156-A1LYA
4.55	Single	8IEP	A1LYA	8IEP-GPR156-A1LYA
4.55	Single	8IEP	A1LYA	8IEP-GPR156-A1LYA
4.55	Single	8INR	Alpha-MSH	8INR-MC₅-α-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
4.55	Single	8K3Z	CXCL12	8K3Z-CXCR4-CXCL12-Gi1/β1/γ1
4.55	Single	8KIG	SHU9119	8KIG-MC₃-SHU9119-Ca
4.55	Single	8WDT	photoNECA	8WDT-A_2A-photoNECA
4.55	Single	8ZJD	Kisspeptin-10	8ZJD-Kiss1-Kisspeptin-10-chim(NtGi1-Gq)/β1/γ1
4.55	Single	9BKJ	Cholecystokinin-8	9BKJ-CCK_A-Cholecystokinin-8-chim(NtGi1-Gs-CtGq)/β1/γ2
4.55	Single	9L3Y	Retinoic acid receptor responder protein 2	9L3Y-CML2-Retinoic acid receptor responder protein 2-Gi1/β1/γ2
4.55	Consensus	class-a_on_gp	Orthosteric Ligand	sensory_on_gp alicarboxylic_on_gp amine_on_gp lipid_on_gp nucleotide_on_gp peptide_on_gp protein_on_gp
4.55	Consensus	cxcr4_on	Orthosteric Ligand	8K3Z-CXCR4-CXCL12-Gi1/β1/γ1
4.55	Consensus	gi_opioid	Orthosteric Ligand	8F7R-μ-Endomorphin-Gi1/β1/γ2 8EF5-μ-Fentanyl-Gi1/β1/γ2 7SCG-μ-FH210-Gi1/β1/γ2 7T2H-μ-Lofentanil-Gi1/β1/γ2 7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2 8DZP-κ-momSalB-Gi1/β1/γ2 8EF6-μ-Morphine-Gi1/β1/γ2 8F7X-NOP-Nociceptin-Gi1/β1/γ2 8EFB-μ-Oliceridine-Gi1/β1/γ2 7U2L-μ-PubChem 163201242-Gi1/β1/γ2 8EFO-μ-PZM21-Gi1/β1/γ2 8EFL-μ-SR17018-Gi1/β1/γ2 8F7Q-μ-β-Endorphin-Gi1/β1/γ2 7U2K-μ-C6-guano-Gi1/β1/γ2 8EFQ-μ-Damgo-Gi1/β1/γ2 8F7S-δ-Deltorphin-Gi1/β1/γ2 8F7W-κ-Dynorphin-Gi1/β1/γ2
4.55	Consensus	gq_kisspeptin	Orthosteric Ligand	8ZJD-Kiss1-Kisspeptin-10-chim(NtGi1-Gq)/β1/γ1
4.55	Consensus	kiss1_on_gp	Orthosteric Ligand	8ZJD-Kiss1-Kisspeptin-10-chim(NtGi1-Gq)/β1/γ1
4.55	Consensus	kisspeptin_on_gp	Orthosteric Ligand	kiss1_on_gp
4.55	Consensus	lpl_on	Orthosteric Ligand	s1p_on lpa_on
4.55	Consensus	lpl_on_gp	Orthosteric Ligand	s1p_on_gp lpa_on_gp
4.55	Consensus	mop_off	Orthosteric Ligand	4DKL-μ-β-Funaltrexamine 8QOT-μ-Nanobody-E 7UL4-μ-Alvimopan
4.55	Consensus	nk3_on	Orthosteric Ligand	8JBF-NK₃-Senktide-chim(NtGi1-Gs-CtGq)/β1/γ2
4.55	Consensus	nk3_on_gp	Orthosteric Ligand	8JBF-NK₃-Senktide-chim(NtGi1-Gs-CtGq)/β1/γ2
4.55	Consensus	nmur1_on_gp	Orthosteric Ligand	7W53-NMUR1-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
4.55	Consensus	nop_on	Orthosteric Ligand	8F7X-NOP-Nociceptin-Gi1/β1/γ2
4.55	Consensus	nop_on_gp	Orthosteric Ligand	8F7X-NOP-Nociceptin-Gi1/β1/γ2
4.55	Consensus	p2y_on	Orthosteric Ligand	p2y1_on p2y10_on p2y12_on
4.35	Single	3QAK	UK-432097	3QAK-A_2A-UK-432097
4.35	Single	6HLO	Aprepitant	6HLO-NK₁-Aprepitant
4.35	Single	7CUM	Phospholipid	7CUM-GABA_B1, GABA_B2-CGP54626-Phospholipid
4.35	Single	7CUM	Phospholipid	7CUM-GABA_B1, GABA_B2-CGP54626-Phospholipid
4.35	Single	7DDZ	JNJ-31020028	7DDZ-Y₂-JNJ-31020028
4.35	Single	7EZK	Cholecystokinin-8	7EZK-CCK_A-Cholecystokinin-8-chim(NtGi1-Gs)/β1/γ2
4.35	Single	7RMI	Substance-P	7RMI-NK₁-Substance-P-chim(Gs-CtGq)/β1/γ2
4.35	Single	8F7Q	Beta-Endorphin	8F7Q-μ-β-Endorphin-Gi1/β1/γ2
4.35	Single	8F7S	Deltorphin	8F7S-δ-Deltorphin-Gi1/β1/γ2
4.35	Single	8F7W	Dynorphin	8F7W-κ-Dynorphin-Gi1/β1/γ2
4.35	Single	8IBV	Motilin	8IBV-Motilin-Motilin-chim(NtGi1-Gs-CtGq)/β1/γ2
4.35	Single	8IEB	A1LYA	8IEB-GPR156-A1LYA
4.35	Single	8JBH	Substance-P	8JBH-NK₃-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
4.35	Single	8WSS	Pro-MCH	8WSS-MCH1-Pro-MCH-Gi1/β1/γ1
4.35	Single	9EAI	Nanobody AT209	9EAI-AT₁-Losartan-Nanobody AT209
4.35	Consensus	cckb_on	Orthosteric Ligand	8IA7-CCK_B-Cholecystokinin-8-chim(NtGi1L-Gq)/β1/γ2 7XOW-CCK_B-Gastrin-chim(NtGi1-Gq)/β1/γ2 7F8V-CCK_B-Gastrin-17-Gi2/β1/γ2
4.35	Consensus	ccr8_on_gp	Orthosteric Ligand	8KFX-CCR8-LMD-009-Gi1/β1/γ2 8KFY-CCR8-ZK-756326-Gi1/β1/γ2 8U1U-CCR8-CCL1-Gi1/β1/γ2
4.35	Consensus	compl-peptide_on	Orthosteric Ligand	c5a1_on c3a_on
4.35	Consensus	dop_on_gp	Orthosteric Ligand	8F7S-δ-Deltorphin-Gi1/β1/γ2
4.35	Consensus	gi_cck	Orthosteric Ligand	7EZH-CCK_A-Cholecystokinin-8-Gi1/β1/γ2 7F8V-CCK_B-Gastrin-17-Gi2/β1/γ2
4.35	Consensus	gi_ghrelin	Orthosteric Ligand	7NA7-Ghrelin-Ghrelin-27-Gi1/β1/γ2 7NA8-Ghrelin-PubChem 178024-Gi1/β1/γ2
4.35	Consensus	mc5_on	Orthosteric Ligand	8INR-MC₅-α-MSH-Ca-chim(NtGi1-Gs)/β1/γ2 8IOD-MC₅-PG-901-Ca-chim(NtGi1-Gs)/β1/γ2
4.35	Consensus	npy2_off	Orthosteric Ligand	7DDZ-Y₂-JNJ-31020028
4.35	Consensus	s1p3_on_gp	Orthosteric Ligand	7EW3-S1P₃-S1P-Gi1/β1/γ2 7EW4-S1P₃-CYM5541-Gi1/β1/γ2 7EW2-S1P₃-Fingolimod-Gi1/β1/γ2
4.35	Consensus	sst4_on	Orthosteric Ligand	7XMS-SST4-Somatostatin-14-Gi1/β1/γ2 7XMT-SST4-J-2156-Gi1/β1/γ2
4.35	Consensus	sst4_on_gp	Orthosteric Ligand	7XMS-SST4-Somatostatin-14-Gi1/β1/γ2 7XMT-SST4-J-2156-Gi1/β1/γ2
4.35	Consensus	tachykinin_on_gp	Orthosteric Ligand	nk1_on_gp nk2_on_gp nk3_on_gp
4.17	Single	5WF5	UK-432097	5WF5-A_2A-UK-432097
4.17	Single	6MEO	Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4	6MEO-CCR5-Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4
4.17	Single	6PT2	KGCHM07	6PT2-δ-KGCHM07
4.17	Single	7F4D	Alpha-MSH	7F4D-MC₁-α-MSH-chim(NtGi1-Gs)/β1/γ2
4.17	Single	7MBX	Cholecystokinin-8	7MBX-CCK_A-Cholecystokinin-8-Gs/β1/γ1
4.17	Single	7O7F	6P4-CCL5	7O7F-CCR5-6P4-CCL5-Gi1/β1/γ1
4.17	Single	7T6T	fMLFII	7T6T-FPR1-ALX-fMLFII-Gi1/β1/γ2
4.17	Single	7TD0	LPA	7TD0-LPA₁-LPA-Gi1/β1/γ2
4.17	Single	7TD2	LPA	7TD2-LPA₁-LPA-Gi1/β1/γ2
4.17	Single	7W55	Neuromedin-U-25	7W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
4.17	Single	8XIQ	L796778	8XIQ-SST3-L796778-chim(NtGi1-Gs-CtGi1)/β1/γ2
4.17	Single	8XIR	Pasireotide	8XIR-SST3-Pasireotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
4.17	Single	9B54	A1AIW	9B54-CB₁-A1AIW-Gi1/β1/γ2
4.17	Consensus	c5a1_on	Orthosteric Ligand	8HK5-C5a₁-Complement C5-Gi1/β1/γ2 7Y66-C5a₁-BM213-Gi1/β1/γ2 7Y67-C5a₁-C089 peptide-Gi1/β1/γ2 7Y64-C5a₁-C5a anaphylatoxin-Gi1/β1/γ2
4.17	Consensus	cckb_on_gp	Orthosteric Ligand	8IA7-CCK_B-Cholecystokinin-8-chim(NtGi1L-Gq)/β1/γ2 7XOW-CCK_B-Gastrin-chim(NtGi1-Gq)/β1/γ2 7F8V-CCK_B-Gastrin-17-Gi2/β1/γ2
4.17	Consensus	compl-peptide_on_gp	Orthosteric Ligand	c5a1_on_gp c3a_on_gp
4.17	Consensus	cxcr4_on_gp	Orthosteric Ligand	8K3Z-CXCR4-CXCL12-Gi1/β1/γ1
4.17	Consensus	gi_somatostatin	Orthosteric Ligand	7WIC-SST2-Somatostatin-14-Gi1/β1/γ2 7XMS-SST4-Somatostatin-14-Gi1/β1/γ2 8X8L-SST5-Cortistatin-chim(NtGi1-Gs-CtGi1)/β1/γ2 7XMT-SST4-J-2156-Gi1/β1/γ2 7WIG-SST2-L-054,264-Gi1/β1/γ2 8X8N-SST5-Octreotide-chim(NtGi1-Gs-CtGi1)/β1/γ2 7YAE-SST2-Octreotide-Gi1/β1/γ2 7YAC-SST2-Paltusotine-Gi1/β1/γ2
4.17	Consensus	gs_cck	Orthosteric Ligand	7MBX-CCK_A-Cholecystokinin-8-Gs/β1/γ1
4.17	Consensus	gs_class-a	Orthosteric Ligand	gs_peptide gs_nucleotide gs_amine
4.17	Consensus	nmur2_on	Orthosteric Ligand	7W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
4.17	Consensus	nmur2_on_gp	Orthosteric Ligand	7W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
4.17	Consensus	peptide_offon	Orthosteric Ligand	peptide_off peptide_on
4.17	Consensus	somatostatin_on	Orthosteric Ligand	sst2_on sst4_on sst5_on
4.17	Consensus	somatostatin_on_gp	Orthosteric Ligand	sst2_on_gp sst4_on_gp sst5_on_gp
4.00	Single	5WB2	CX3CL1.35	5WB2-US28-CX3CL1.35
4.00	Single	6MET	Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4	6MET-CCR5-Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4
4.00	Single	6WIV	PubChem 52923113; PubChem 52924645	6WIV-GABA_B1, GABA_B2-PubChem 52923113; PubChem 52924645
4.00	Single	7DW9	AVP	7DW9-V₂-AVP-chim(NtGi1-Gs)/β1/γ2
4.00	Single	7F4H	Afamelanotide	7F4H-MC₁-Afamelanotide-chim(NtGi1-Gs)/β1/γ2
4.00	Single	7T10	Somatostatin-14	7T10-SST2-Somatostatin-14-Gi3/β1/γ2
4.00	Single	7W40	Bombesin	7W40-BB₂-Bombesin-chim(NtGi1L-Gq)/β1/γ2
4.00	Single	7W57	Neuromedin-S	7W57-NMUR2-Neuromedin-S-chim(NtGi1-Gs-CtGq)/β1/γ2
4.00	Single	7WUI	IP15	7WUI-ADGRG2-IP15-chim(NtGi1-Gs)/β1/γ2
4.00	Single	7YON	Peptide-YY(3-36)	7YON-Y₂-Peptide-YY(3-36)-Gi1/β1/γ2
4.00	Single	8H4K	GW9508	8H4K-FFA4-GW9508-chim(NtGi1-Gs-CtGq)/β1/γ2
4.00	Single	8IED	A1LYA	8IED-GPR156-A1LYA-Go/β1/γ2
4.00	Single	8IED	A1LYA	8IED-GPR156-A1LYA-Go/β1/γ2
4.00	Single	8WST	Pro-MCH	8WST-MCH2-Pro-MCH-chim(NtGi1L-Gs-CtGq)/β1/γ2
4.00	Single	8XWQ	Endothelin-1	8XWQ-ET_B-Endothelin-1-Gi1/β1/γ2
4.00	Single	9BKK	Cholecystokinin-8	9BKK-CCK_A-Cholecystokinin-8-chim(NtGi1-Gs-CtGq)/β1/γ2
4.00	Consensus	c5a1_on_gp	Orthosteric Ligand	8HK5-C5a₁-Complement C5-Gi1/β1/γ2 7Y66-C5a₁-BM213-Gi1/β1/γ2 7Y67-C5a₁-C089 peptide-Gi1/β1/γ2 7Y64-C5a₁-C5a anaphylatoxin-Gi1/β1/γ2
4.00	Consensus	gi_class-a	Orthosteric Ligand	gi_peptide gi_sensory gi_alicarboxylic gi_amine gi_lipid gi_nucleotide gi_protein
4.00	Consensus	gs_vasop-oxy	Orthosteric Ligand	7DW9-V₂-AVP-chim(NtGi1-Gs)/β1/γ2
4.00	Consensus	mc5_on_gp	Orthosteric Ligand	8INR-MC₅-α-MSH-Ca-chim(NtGi1-Gs)/β1/γ2 8IOD-MC₅-PG-901-Ca-chim(NtGi1-Gs)/β1/γ2
4.00	Consensus	neuromedin-u_on	Orthosteric Ligand	nmur1_on nmur2_on
4.00	Consensus	peptide_offon_gp	Orthosteric Ligand	peptide_on_gp peptide_off
4.00	Consensus	tachykinin_on	Orthosteric Ligand	nk1_on nk2_on nk3_on
4.00	Consensus	v2_on	Orthosteric Ligand	7DW9-V₂-AVP-chim(NtGi1-Gs)/β1/γ2
4.00	Consensus	v2_on_gp	Orthosteric Ligand	7DW9-V₂-AVP-chim(NtGi1-Gs)/β1/γ2
4.00	Consensus	vasop-oxy_on	Orthosteric Ligand	v2_on
4.00	Consensus	vasop-oxy_on_gp	Orthosteric Ligand	v2_on_gp
3.85	Single	5YQZ	Glucagon analogue	5YQZ-Glucagon-Glucagon analogue
3.85	Single	7F6H	Bradykinin	7F6H-BK₂-Bradykinin-Gq/β1/γ2
3.85	Single	7F6I	Kallidin	7F6I-BK₂-Kallidin-Gq/β1/γ2
3.85	Single	7F9Y	Ghrelin-28	7F9Y-Ghrelin-Ghrelin-28-chim(NtGi1-Gs-CtGq)/β1/γ2
3.85	Single	7P02	Protachykinin-1	7P02-NK₁-Protachykinin-1-chim(NtGi1-Gs)/β1/γ2
3.85	Single	7Y64	C5a anaphylatoxin	7Y64-C5a₁-C5a anaphylatoxin-Gi1/β1/γ2
3.85	Single	8HCX	Endothelin-1	8HCX-ET_B-Endothelin-1-chim(NtGi2L-Gs-CtGq)/β1/γ2
3.85	Single	8HK5	Complement C5	8HK5-C5a₁-Complement C5-Gi1/β1/γ2
3.85	Single	8IA2	C5a anaphylatoxin	8IA2-C5a₁-C5a anaphylatoxin-Go/β1/γ2
3.85	Single	8WWK	MCH	8WWK-MCH1-MCH-Gi1/β1/γ2
3.85	Single	8XGO	TAK448	8XGO-Kiss1-TAK448-chim(NtGi1-Gq)/β1/γ2
3.85	Single	8XVH	Endothelin-1	8XVH-ET_B-Endothelin-1-chim(Gs-CtGq)/β1/γ2
3.85	Single	8XVI	Endothelin-1	8XVI-ET_A-Endothelin-1-chim(Gs-CtGq)/β1/γ2
3.85	Single	8ZRT	ET-1	8ZRT-ET_B-ET-1
3.85	Consensus	mc1_on	Orthosteric Ligand	7F4H-MC₁-Afamelanotide-chim(NtGi1-Gs)/β1/γ2 7F4D-MC₁-α-MSH-chim(NtGi1-Gs)/β1/γ2 7F4I-MC₁-SHU9119-chim(NtGi1-Gs)/β1/γ2
3.85	Consensus	mc1_on_gp	Orthosteric Ligand	7F4H-MC₁-Afamelanotide-chim(NtGi1-Gs)/β1/γ2 7F4D-MC₁-α-MSH-chim(NtGi1-Gs)/β1/γ2 7F4I-MC₁-SHU9119-chim(NtGi1-Gs)/β1/γ2
3.85	Consensus	neuromedin-u_on_gp	Orthosteric Ligand	nmur1_on_gp nmur2_on_gp
3.85	Consensus	opioid_on	Orthosteric Ligand	mop_on nop_on dop_on kop_on
3.85	Consensus	p2y10_on	Orthosteric Ligand	8KGG-P2Y10-LPS-chim(NtGi2-G13)/β1/γ2
3.85	Consensus	sst5_on_gp	Orthosteric Ligand	8X8L-SST5-Cortistatin-chim(NtGi1-Gs-CtGi1)/β1/γ2 8X8N-SST5-Octreotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
3.70	Single	5UIW	5P7-CCL5	5UIW-CCR5-5P7-CCL5
3.70	Single	7F8V	Gastrin-17	7F8V-CCK_B-Gastrin-17-Gi2/β1/γ2
3.70	Single	7W3Z	Gastrin Releasing Peptide	7W3Z-BB₂-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/β1/γ2
3.70	Single	8H0P	NMB30	8H0P-BB₁-NMB30-chim(NtGi1-Gs-CtGq)/β1/γ2
3.70	Single	8XQF	Apelin-13	8XQF-Apelin-Apelin-13-Gi1/β1/γ2
3.70	Single	8XVE	BQ3020	8XVE-ET_B-BQ3020-chim(Gs-CtGq)/β1/γ2
3.70	Consensus	ccr5_off	Orthosteric Ligand	5UIW-CCR5-5P7-CCL5
3.70	Consensus	ccr5_on	Orthosteric Ligand	7O7F-CCR5-6P4-CCL5-Gi1/β1/γ1 7F1Q-CCR5-MIP-1a-Gi1/β1/γ2
3.70	Consensus	gi_compl-pept	Orthosteric Ligand	8HK5-C5a₁-Complement C5-Gi1/β1/γ2 8IA8-C3a_B-E7 peptide-Gi1/β1/γ2 7Y66-C5a₁-BM213-Gi1/β1/γ2 7Y67-C5a₁-C089 peptide-Gi1/β1/γ2 8HK2-C3a_B-C3a anaphylatoxin-Gi1/β1/γ2 7Y64-C5a₁-C5a anaphylatoxin-Gi1/β1/γ2
3.70	Consensus	gi_peptide	Orthosteric Ligand	gi_cck gi_apelin gi_compl-pept gi_endothelin gi_formylpeptide gi_galanin gi_ghrelin gi_npy gi_neurotensin gi_opioid gi_orexin gi_relaxin gi_somatostatin
3.70	Consensus	opioid_on_gp	Orthosteric Ligand	mop_on_gp nop_on_gp dop_on_gp kop_on_gp
3.57	Single	7F4F	Afamelanotide	7F4F-MC₁-Afamelanotide-chim(NtGi1-Gs)/β1/γ2
3.57	Single	7XAT	Somatostatin-14	7XAT-SST2-Somatostatin-14-Gi1/β1/γ2
3.57	Single	8FEG	(DNCP)-Beta-Naloxamine	8FEG-κ-(DNCP)-β-Naloxamine-Gi1/β1/γ2
3.57	Single	8WWL	MCH	8WWL-MCH1-MCH-Gi1/β1/γ2
3.57	Single	8XWP	Endothelin-1	8XWP-ET_B-Endothelin-1-Gi1/β1/γ2
3.57	Consensus	gq_peptide	Orthosteric Ligand	gq_cck gq_kisspeptin gq_bradykinin gq_bombesin gq_angiotensin
3.57	Consensus	peptide_on	Orthosteric Ligand	cck_on angiotensin_on apelin_on bombesin_on bradykinin_on compl-peptide_on endothelin_on formylpeptide_on galanin_on ghrelin_on kisspeptin_on melanocortin_on motilin_on neuromedin-u_on npy_on neurotensin_on opioid_on orexin_on relaxin_on somatostatin_on tachykinin_on trh_on vasop-oxy_on
3.57	Consensus	peptide_on_gp	Orthosteric Ligand	cck_on_gp angiotensin_on_gp apelin_on_gp bombesin_on_gp bradykinin_on_gp compl-peptide_on_gp endothelin_on_gp formylpeptide_on_gp galanin_on_gp ghrelin_on_gp kisspeptin_on_gp melanocortin_on_gp motilin_on_gp neuromedin-u_on_gp npy_on_gp neurotensin_on_gp opioid_on_gp orexin_on_gp relaxin_on_gp somatostatin_on_gp tachykinin_on_gp trh_on_gp vasop-oxy_on_gp
3.45	Single	6IGL	IRL1620	6IGL-ET_B-IRL1620
3.45	Single	8IY5	Endothelin-1	8IY5-ET_B-Endothelin-1-Gi1/β1/γ2
3.45	Single	8IY6	Endothelin-1	8IY6-ET_B-Endothelin-1
3.45	Single	8WWN	MCH	8WWN-MCH1-MCH-Gi1/β1/γ2
3.45	Single	8Y52	BA1	8Y52-BB₃-BA1-chim(NtGi1-Gs-CtGq)/β1/γ2
3.45	Consensus	bk2_on	Orthosteric Ligand	7F6H-BK₂-Bradykinin-Gq/β1/γ2 7F6I-BK₂-Kallidin-Gq/β1/γ2
3.45	Consensus	bk2_on_gp	Orthosteric Ligand	7F6H-BK₂-Bradykinin-Gq/β1/γ2 7F6I-BK₂-Kallidin-Gq/β1/γ2
3.45	Consensus	bradykinin_on	Orthosteric Ligand	bk2_on
3.45	Consensus	bradykinin_on_gp	Orthosteric Ligand	bk2_on_gp
3.45	Consensus	endothelin_on	Orthosteric Ligand	etb_on eta_on
3.45	Consensus	etb_on	Orthosteric Ligand	8IY5-ET_B-Endothelin-1-Gi1/β1/γ2 8HBD-ET_B-IRL1620-Gi1/β1/γ2
3.45	Consensus	gq_bradykinin	Orthosteric Ligand	7F6H-BK₂-Bradykinin-Gq/β1/γ2 7F6I-BK₂-Kallidin-Gq/β1/γ2
3.33	Single	5GLH	Endothelin-1	5GLH-ET_B-Endothelin-1
3.33	Single	6IGK	Endothelin-3	6IGK-ET_B-Endothelin-3
3.33	Single	8U1U	CCL1	8U1U-CCR8-CCL1-Gi1/β1/γ2
3.33	Single	8ZJE	TAK-448	8ZJE-Kiss1-TAK-448-chim(NtGi1-Gq)/β1/γ1
3.33	Consensus	bb2_on	Orthosteric Ligand	7W40-BB₂-Bombesin-chim(NtGi1L-Gq)/β1/γ2 7W3Z-BB₂-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/β1/γ2
3.33	Consensus	bb2_on_gp	Orthosteric Ligand	7W40-BB₂-Bombesin-chim(NtGi1L-Gq)/β1/γ2 7W3Z-BB₂-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/β1/γ2
3.33	Consensus	bombesin_on	Orthosteric Ligand	bb2_on
3.33	Consensus	bombesin_on_gp	Orthosteric Ligand	bb2_on_gp
3.33	Consensus	ccr5_on_gp	Orthosteric Ligand	7O7F-CCR5-6P4-CCL5-Gi1/β1/γ1 7F1Q-CCR5-MIP-1a-Gi1/β1/γ2
3.33	Consensus	gi_endothelin	Orthosteric Ligand	8IY5-ET_B-Endothelin-1-Gi1/β1/γ2 8HBD-ET_B-IRL1620-Gi1/β1/γ2
3.33	Consensus	gq_bombesin	Orthosteric Ligand	7W40-BB₂-Bombesin-chim(NtGi1L-Gq)/β1/γ2 7W3Z-BB₂-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/β1/γ2
3.23	Single	8HBD	IRL1620	8HBD-ET_B-IRL1620-Gi1/β1/γ2
3.23	Consensus	endothelin_on_gp	Orthosteric Ligand	etb_on_gp eta_on_gp
3.23	Consensus	etb_on_gp	Orthosteric Ligand	8IY5-ET_B-Endothelin-1-Gi1/β1/γ2 8HBD-ET_B-IRL1620-Gi1/β1/γ2
3.12	Single	6LRY	Sarafotoxin-B	6LRY-ET_B-Sarafotoxin-B

PDB Summary
PDB	7Y14
Class	A
SubFamily	Orphan
Type	Orphan
SubType	MRGPRD
Species	Homo Sapiens
Ligand	Beta-Alanine
Other Ligand(s)	-
Protein Partners	-
PDB Resolution	3.2
Date	2022-07-20
D.O.I.	10.1038/s42003-022-03668-3

Net Summary
I_min	3.56
Number of Linked Nodes	248
Number of Links	268
Number of Hubs	31
Number of Links mediated by Hubs	119
Number of Communities	5
Number of Nodes involved in Communities	38
Number of Links involved in Communities	52

Path Summary
Number Of Nodes in MetaPath	52
Number Of Links MetaPath	51
Number of Shortest Paths	67314
Length Of Smallest Path	3
Average Path Length	19.5539
Length of Longest Path	40
Minimum Path Strength	1.44
Average Path Strength	7.42148
Maximum Path Strength	30.885
Minimum Path Correlation	0.7
Average Path Correlation	0.92186
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	3.84615
Average % Of Corr. Nodes	37.6317
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	38.2121
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function	• binding • tetrapyrrole binding • heme binding • electron transfer activity • cation binding • transition metal ion binding • iron ion binding • ion binding • metal ion binding • small molecule binding • molecular transducer activity • G protein-coupled receptor activity • transmembrane signaling receptor activity • signaling receptor activity • peptide receptor activity • G protein-coupled peptide receptor activity • electron transport chain • metabolic process • cellular process • generation of precursor metabolites and energy • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cell communication • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway
Gene Ontology	Biological Process	• electron transport chain • metabolic process • cellular process • generation of precursor metabolites and energy • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cell communication • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • signal transduction • regulation of systemic arterial blood pressure by renin-angiotensin • multicellular organismal process • regulation of systemic arterial blood pressure by hormone • system process • regulation of systemic arterial blood pressure mediated by a chemical signal • negative regulation of blood pressure • renal control of peripheral vascular resistance involved in regulation of systemic arterial blood pressure • circulatory system process • angiotensin-mediated vasodilation involved in regulation of systemic arterial blood pressure • negative regulation of systemic arterial blood pressure • regulation of biological quality • blood vessel diameter maintenance • renal system process involved in regulation of systemic arterial blood pressure • blood circulation • regulation of tube diameter • maintenance of blood vessel diameter homeostasis by renin-angiotensin • renal system process • regulation of blood pressure • regulation of tube size • regulation of systemic arterial blood pressure • endocrine process • vascular process in circulatory system • vasodilation • regulation of anatomical structure size • cellular anatomical structure • periplasmic space • cell periphery • plasma membrane • membrane • extracellular region • extracellular space
Gene Ontology	Cellular Component
SCOP2	Domain Identifier
SCOP2	Family Identifier
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	BAL
PDB Residues	L:L:?1
Environment Details	Open EMBL-EBI Page
Code	BAL
Name	beta-Alanine
Synonyms	β-aminopropionic acid
Identifier
Formula	C3 H7 N O2
Molecular Weight	89.093
SMILES
PubChem	4755801
Formal Charge	0
Total Atoms	13
Total Chiral Atoms	0
Total Bonds	12
Total Aromatic Bonds	0


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	Q8TDS7
Sequence	>7Y14_Chain_R T V H T A Y L V L S S L A M F T C L C G M A G N S M V I W L L G F R M H R N P F C I Y I L N L A A A D L L F L F S M A S T L S L E T Q P L V N T T D K V H E L M K R L M Y F A Y T V G L S L L T A I S T Q R C L S V L F P I W F K C H R P R H L S A W V C G L L W T L C L L M N G L T S S F C S K F L K F N E D R C F R V D M V Q A A L I M G V L T P V M T L S S L T L F V W V R R S S Q Q W R R Q P T R L F V V V L A S V L V F L I C S L P L S I Y W F V L Y W L S L P P E M Q V L C F S L S R L S S S V S S S A N P V I Y F L V G S R R S H Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	9DQJ	A	Orphan	Orphan	MRGPRD	Homo sapiens	EP-3945	-	chim(NtGi1-Gs-CtGq)/β1/γ2	2.9	2024-12-11	10.1016/j.celrep.2024.114942
	9DQJ (No Gprot)	A	Orphan	Orphan	MRGPRD	Homo sapiens	EP-3945	-		2.9	2024-12-11	10.1016/j.celrep.2024.114942
	9DQH	A	Orphan	Orphan	MRGPRD	Homo sapiens	EP-2825	-	chim(NtGi1-Gs-CtGq)/β1/γ2	2.92	2024-12-11	10.1016/j.celrep.2024.114942
	9DQH (No Gprot)	A	Orphan	Orphan	MRGPRD	Homo sapiens	EP-2825	-		2.92	2024-12-11	10.1016/j.celrep.2024.114942
	7Y14	A	Orphan	Orphan	MRGPRD	Homo sapiens	β-Alanine	-	-	3.2	2022-07-20	10.1038/s42003-022-03668-3
	7Y13	A	Orphan	Orphan	MRGPRD	Homo sapiens	-	-	-	3.1	2022-07-20	10.1038/s42003-022-03668-3
	7Y15	A	Orphan	Orphan	MRGPRD	Homo sapiens	-	-	Gi1/β1/γ2	2.9	2022-07-20	10.1038/s42003-022-03668-3
	7Y15 (No Gprot)	A	Orphan	Orphan	MRGPRD	Homo sapiens	-	-		2.9	2022-07-20	10.1038/s42003-022-03668-3
	7Y12	A	Orphan	Orphan	MRGPRD	Homo sapiens	β-Alanine	-	Gi1/β1/γ2	3.1	2022-07-20	10.1038/s42003-022-03668-3
	7Y12 (No Gprot)	A	Orphan	Orphan	MRGPRD	Homo sapiens	β-Alanine	-		3.1	2022-07-20	10.1038/s42003-022-03668-3

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