Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


2D representation of the interactions of this orthosteric/allosteric ligand.


Links and nodes colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:F484 R:R:Y207 6.19 1 Yes Yes 6 7 1 2
R:R:V488 R:R:Y207 7.57 1 No Yes 6 7 2 2
R:R:I215 R:R:P220 5.08 0 No Yes 5 8 2 2
R:R:I215 R:R:M301 7.29 0 No No 5 4 2 1
R:R:N219 R:R:P220 6.52 1 Yes Yes 7 8 1 2
R:R:L221 R:R:N219 5.49 1 Yes Yes 6 7 1 1
R:R:F222 R:R:N219 8.46 1 Yes Yes 6 7 2 1
R:R:N219 R:R:V386 4.43 1 Yes Yes 7 5 1 2
L:L:?1 R:R:N219 12.94 1 Yes Yes 0 7 0 1
R:R:L221 R:R:P220 3.28 1 Yes Yes 6 8 1 2
R:R:F484 R:R:P220 4.33 1 Yes Yes 6 8 1 2
R:R:F222 R:R:L221 2.44 1 Yes Yes 6 6 2 1
R:R:F484 R:R:L221 2.44 1 Yes Yes 6 6 1 1
R:R:L221 R:R:P513 6.57 1 Yes Yes 6 8 1 1
L:L:?1 R:R:L221 1.86 1 Yes Yes 0 6 0 1
R:R:F222 R:R:V386 2.62 1 Yes Yes 6 5 2 2
R:R:F222 R:R:P513 8.67 1 Yes Yes 6 8 2 1
R:R:F222 R:R:L515 3.65 1 Yes Yes 6 5 2 2
R:R:S387 R:R:W281 2.47 1 Yes Yes 8 7 2 2
R:R:M525 R:R:W281 9.31 1 No Yes 5 7 2 2
R:R:W281 W:W:?1 4.57 1 Yes Yes 7 0 2 1
R:R:L303 R:R:M301 4.24 1 No No 3 4 1 1
L:L:?1 R:R:M301 5.71 1 Yes No 0 4 0 1
L:L:?1 R:R:L303 1.86 1 Yes No 0 3 0 1
R:R:L325 R:R:M525 4.24 1 No No 5 5 2 2
R:R:L325 W:W:?1 2.78 1 No Yes 5 0 2 1
R:R:F332 W:W:?1 2.45 1 Yes Yes 9 0 2 1
R:R:K395 R:R:Q380 4.07 1 Yes No 3 7 1 2
R:R:N396 R:R:Q380 11.88 1 No No 7 7 2 2
R:R:D382 R:R:G383 3.35 1 Yes Yes 9 8 1 2
R:R:D382 R:R:Y394 6.9 1 Yes Yes 9 5 1 1
R:R:D382 R:R:K395 2.77 1 Yes Yes 9 3 1 1
L:L:?1 R:R:D382 1.83 1 Yes Yes 0 9 0 1
R:R:D384 R:R:V386 5.84 1 Yes Yes 8 5 1 2
R:R:D384 R:R:S387 11.78 1 Yes Yes 8 8 1 2
R:R:D384 R:R:Y394 16.09 1 Yes Yes 8 5 1 1
L:L:?1 R:R:D384 1.83 1 Yes Yes 0 8 0 1
R:R:F391 R:R:Y394 8.25 1 Yes Yes 8 5 2 1
R:R:F391 W:W:?1 14.67 1 Yes Yes 8 0 2 1
L:L:?1 R:R:Y394 8.68 1 Yes Yes 0 5 0 1
R:R:Y394 W:W:?1 7.06 1 Yes Yes 5 0 1 1
R:R:K395 R:R:N396 6.99 1 Yes No 3 7 1 2
R:R:E481 R:R:K395 4.05 1 No Yes 5 3 1 1
L:L:?1 R:R:K395 10.44 1 Yes Yes 0 3 0 1
R:R:H470 R:R:R400 3.39 1 Yes Yes 7 9 2 2
R:R:D473 R:R:R400 10.72 1 No Yes 8 9 1 2
R:R:H470 R:R:V404 12.45 1 Yes No 7 7 2 2
R:R:V404 W:W:?1 5.98 1 No Yes 7 0 2 1
R:R:I408 R:R:V463 4.61 1 No No 7 7 2 2
R:R:I408 W:W:?1 10.03 1 No Yes 7 0 2 1
R:R:V463 W:W:?1 2.99 1 No Yes 7 0 2 1
R:R:H470 R:R:T466 6.85 1 Yes No 7 8 2 2
R:R:T466 W:W:?1 2.96 1 No Yes 8 0 2 1
R:R:H470 R:R:N521 2.55 1 Yes No 7 8 2 2
R:R:H470 W:W:?1 10.33 1 Yes Yes 7 0 2 1
R:R:D473 R:R:W480 2.23 1 No Yes 8 9 1 1
L:L:?1 R:R:D473 11.87 1 Yes No 0 8 0 1
R:R:N476 R:R:W480 25.99 0 No Yes 6 9 2 1
R:R:Q477 R:R:W480 2.19 0 No Yes 6 9 2 1
R:R:E481 R:R:Q477 6.37 1 No No 5 6 1 2
R:R:N511 R:R:W480 11.3 1 Yes Yes 4 9 2 1
R:R:P513 R:R:W480 14.86 1 Yes Yes 8 9 1 1
L:L:?1 R:R:W480 3.83 1 Yes Yes 0 9 0 1
L:L:?1 R:R:E481 8.92 1 Yes No 0 5 0 1
R:R:F484 R:R:V488 6.55 1 Yes No 6 6 1 2
L:L:?1 R:R:F484 13.94 1 Yes Yes 0 6 0 1
L:L:?1 R:R:P513 3.32 1 Yes Yes 0 8 0 1
R:R:E518 R:R:L515 3.98 0 No Yes 7 5 1 2
R:R:E518 R:R:V517 7.13 0 No No 7 6 1 2
L:L:?1 R:R:E518 8.92 1 Yes No 0 7 0 1
R:R:N521 W:W:?1 5.51 1 No Yes 8 0 2 1
R:R:M525 W:W:?1 18.45 1 No Yes 5 0 2 1
R:R:T528 W:W:?1 19.24 0 No Yes 7 0 2 1
L:L:?1 W:W:?1 2.81 1 Yes Yes 0 0 0 1
R:R:E208 R:R:L303 1.33 0 No No 4 3 2 1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

2D representation of the interactions of this orthosteric/allosteric ligand.


Links and nodes colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:L221 R:R:N219 5.49 1 Yes Yes 6 7 2 2
L:L:?1 R:R:N219 12.94 1 Yes Yes 0 7 1 2
R:R:F484 R:R:L221 2.44 1 Yes Yes 6 6 2 2
R:R:L221 R:R:P513 6.57 1 Yes Yes 6 8 2 2
L:L:?1 R:R:L221 1.86 1 Yes Yes 0 6 1 2
R:R:I234 R:R:W281 7.05 1 Yes Yes 7 7 2 1
R:R:F526 R:R:I234 2.51 1 Yes Yes 9 7 2 2
R:R:F274 R:R:L325 2.44 0 Yes No 9 5 2 1
R:R:F274 R:R:T528 2.59 0 Yes No 9 7 2 1
R:R:V321 R:R:W281 4.9 0 No Yes 8 7 2 1
R:R:S387 R:R:W281 2.47 1 Yes Yes 8 7 2 1
R:R:I389 R:R:W281 5.87 1 No Yes 9 7 2 1
R:R:L522 R:R:W281 4.56 0 No Yes 7 7 2 1
R:R:M525 R:R:W281 9.31 1 No Yes 5 7 1 1
R:R:F526 R:R:W281 2 1 Yes Yes 9 7 2 1
R:R:W281 W:W:?1 4.57 1 Yes Yes 7 0 1 0
R:R:L303 R:R:M301 4.24 1 No No 3 4 2 2
L:L:?1 R:R:M301 5.71 1 Yes No 0 4 1 2
L:L:?1 R:R:L303 1.86 1 Yes No 0 3 1 2
R:R:F318 R:R:Y322 7.22 1 Yes Yes 9 9 2 2
R:R:F318 R:R:F391 6.43 1 Yes Yes 9 8 2 1
R:R:F318 R:R:V392 5.24 1 Yes Yes 9 9 2 2
R:R:F391 R:R:Y322 4.13 1 Yes Yes 8 9 1 2
R:R:L325 R:R:M525 4.24 1 No No 5 5 1 1
R:R:L325 W:W:?1 2.78 1 No Yes 5 0 1 0
R:R:F332 R:R:T336 5.19 1 Yes No 9 7 1 2
R:R:F332 R:R:V411 2.62 1 Yes No 9 5 1 2
R:R:F332 R:R:F455 6.43 1 Yes No 9 8 1 2
R:R:F332 R:R:M532 7.46 1 Yes No 9 8 1 2
R:R:F332 W:W:?1 2.45 1 Yes Yes 9 0 1 0
R:R:D382 R:R:Y394 6.9 1 Yes Yes 9 5 2 1
R:R:D382 R:R:K395 2.77 1 Yes Yes 9 3 2 2
L:L:?1 R:R:D382 1.83 1 Yes Yes 0 9 1 2
R:R:D384 R:R:S387 11.78 1 Yes Yes 8 8 2 2
R:R:D384 R:R:Y394 16.09 1 Yes Yes 8 5 2 1
L:L:?1 R:R:D384 1.83 1 Yes Yes 0 8 1 2
R:R:I389 R:R:S387 4.64 1 No Yes 9 8 2 2
R:R:F391 R:R:V392 3.93 1 Yes Yes 8 9 1 2
R:R:F391 R:R:Y394 8.25 1 Yes Yes 8 5 1 1
R:R:F391 W:W:?1 14.67 1 Yes Yes 8 0 1 0
L:L:?1 R:R:Y394 8.68 1 Yes Yes 0 5 1 1
R:R:Y394 W:W:?1 7.06 1 Yes Yes 5 0 1 0
R:R:E481 R:R:K395 4.05 1 No Yes 5 3 2 2
L:L:?1 R:R:K395 10.44 1 Yes Yes 0 3 1 2
R:R:H470 R:R:R400 3.39 1 Yes Yes 7 9 1 2
R:R:D473 R:R:R400 10.72 1 No Yes 8 9 2 2
R:R:F474 R:R:R400 7.48 1 Yes Yes 6 9 2 2
R:R:H470 R:R:V404 12.45 1 Yes No 7 7 1 1
R:R:V404 W:W:?1 5.98 1 No Yes 7 0 1 0
R:R:I408 R:R:V463 4.61 1 No No 7 7 1 1
R:R:I408 W:W:?1 10.03 1 No Yes 7 0 1 0
R:R:L412 R:R:V463 8.94 0 No No 7 7 2 1
R:R:F455 R:R:M532 4.98 1 No No 8 8 2 2
R:R:F462 R:R:T528 7.78 0 Yes No 7 7 2 1
R:R:V463 W:W:?1 2.99 1 No Yes 7 0 1 0
R:R:H470 R:R:T466 6.85 1 Yes No 7 8 1 1
R:R:T466 W:W:?1 2.96 1 No Yes 8 0 1 0
R:R:C469 R:R:N521 11.02 0 No No 7 8 2 1
R:R:F474 R:R:H470 7.92 1 Yes Yes 6 7 2 1
R:R:H470 R:R:N521 2.55 1 Yes No 7 8 1 1
R:R:H470 W:W:?1 10.33 1 Yes Yes 7 0 1 0
R:R:D473 R:R:W480 2.23 1 No Yes 8 9 2 2
L:L:?1 R:R:D473 11.87 1 Yes No 0 8 1 2
R:R:P513 R:R:W480 14.86 1 Yes Yes 8 9 2 2
L:L:?1 R:R:W480 3.83 1 Yes Yes 0 9 1 2
L:L:?1 R:R:E481 8.92 1 Yes No 0 5 1 2
L:L:?1 R:R:F484 13.94 1 Yes Yes 0 6 1 2
L:L:?1 R:R:P513 3.32 1 Yes Yes 0 8 1 2
L:L:?1 R:R:E518 8.92 1 Yes No 0 7 1 2
R:R:N521 W:W:?1 5.51 1 No Yes 8 0 1 0
R:R:M525 W:W:?1 18.45 1 No Yes 5 0 1 0
R:R:T528 W:W:?1 19.24 0 No Yes 7 0 1 0
L:L:?1 W:W:?1 2.81 1 Yes Yes 0 0 1 0

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB 6XBL
Class F
SubFamily Protein
Type Frizzled
SubType SMO
Species Homo sapiens
Ligand SAG
Other Ligand(s) Cholesterol
Protein Partners Gi1/Beta1/Gamma2
PDB Resolution 3.96
Date 2020-09-30
D.O.I. 10.1038/s41589-020-0646-2
Net Summary
Imin 1.64
Number of Linked Nodes 987
Number of Links 1386
Number of Hubs 279
Number of Links mediated by Hubs 992
Number of Communities 20
Number of Nodes involved in Communities 425
Number of Links involved in Communities 704
Path Summary
Number Of Nodes in MetaPath 80
Number Of Links MetaPath 79
Number of Shortest Paths 13820713
Length Of Smallest Path 3
Average Path Length 37.5686
Length of Longest Path 59
Minimum Path Strength 1.155
Average Path Strength 4.45435
Maximum Path Strength 21.31
Minimum Path Correlation 0.7
Average Path Correlation 0.998395
Maximum Path Correlation 1
Minimum % Of Corr. Nodes 2.94118
Average % Of Corr. Nodes 35.008
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 63.4298
Maximum Path Hubs % 100
AnnotationTypeLinks
Gene OntologyMolecular Function
Gene OntologyBiological Process
Gene OntologyCellular Component
SCOP2Domain Identifier
SCOP2Family Identifier
Membrane Protein Annotations-• Orientations of Proteins in Membranes database (OPM)   • Protein Data Bank of Transmembrane Proteins (PDBTM)   • MemProtMD


Details about the values in these tables can be found in the corresponding documentation page .
CodeV0S
PDB ResiduesL:L:?1
Environment DetailsOpen EMBL-EBI Page
CodeV0S
Name3-chloro-N-[trans-4-(methylamino)cyclohexyl]-N-{[3-(pyridin-4-yl)phenyl]methyl}-1-benzothiophene-2-carboxamide
Synonyms
Identifier3-chloranyl-~{N}-[4-(methylamino)cyclohexyl]-~{N}-[(3-pyridin-4-ylphenyl)methyl]-1-benzothiophene-2-carboxamide
FormulaC28 H28 Cl N3 O S
Molecular Weight490.059
SMILESCNC1CCC(CC1)N(Cc2cccc(c2)c3ccncc3)C(=O)c4c(c5ccccc5s4)Cl
PubChem
Formal Charge0
Total Atoms62
Total Chiral Atoms0
Total Bonds66
Total Aromatic Bonds22

CodeCLR
PDB ResiduesW:W:?1
Environment DetailsOpen EMBL-EBI Page
CodeCLR
NameCholesterol
Synonyms
  • Cholest-5-en-3beta-ol
  • Cholesterin
  • (3β,14β,17α)-cholest-5-en-3-ol
  • Cholesterol
Identifier(3S,8S,9S,10R,13R,14S,17R)-10,13-dimethyl-17-[(2R)-6-methylheptan-2-yl]-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-ol
FormulaC27 H46 O
Molecular Weight386.654
SMILESCC(C)CCC[C@@H](C)[C@H]1CC[C@@H]2[C@@]1(CC[C@H]3[C@H]2CC=C4[C@@]3(CC[C@@H](C4)O)C)C
PubChem5997
Formal Charge0
Total Atoms74
Total Chiral Atoms8
Total Bonds77
Total Aromatic Bonds0

PDBsumOpen PDBsum Page
ChainA
ProteinG Protein α Sub unit
UniProtP63096
Sequence
>6XBL_Chain_A
LSAEDKAAV ERSKMIDRN LREDGEKAA REVKLLLLG AGESGKSTI 
VKQMKGIVE THFTFKDLH FKMFDVGGQ RSERKKWIH CFEGVTAII 
FCVALSDYD LVNRMHESM KLFDSICNN KWFTDTSII LFLNKKDLF 
EEKIKKSPL TICYPEYAG SNTYEEAAA YIQCQFEDL NKRKDTKEI 
YTHFTCATD TKNVQFVFD AVTDVIIKN NLKDCGLF


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainG
ProteinG Protein γ Sub unit
UniProtP59768
Sequence
>6XBL_Chain_G
IAQARKLVE QLKMEANID RIKVSKAAA DLMAYCEAH AKEDPLLTP 
VPASENPF


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainR
ProteinReceptor
UniProtQ99835
Sequence
>6XBL_Chain_R
HCGRAAPCE PLRYNVCLG SVLPYGATS TLLAGDSDS QEEAHGKLV 
LWSGLRNAP RCWAVIQPL LCAVYMPKC ENDRVELPS RTLCQATRG 
PCAIVERER GWPDFLRCT PDRFPEGCT NEVQNIKFN SSGQCEVPL 
VRTDNPKSW YEDVEGCGI QCQNPLFTE AEHQDMHSY IAAFGAVTG 
LCTLFTLAT FVADWRNSN RYPAVILFY VNACFFVGS IGWLAQFMD 
GARREIVCR ADGTMRLGE PTSNETLSC VIIFVIVYY ALMAGVVWF 
VVLTYAWHT SFKALGTTY QPLSGKTSY FHLLTWSLP FVLTVAILA 
VAQVDGDSV SGICFVGYK NYRYRAGFV LAPIGLVLI VGGYFLIRG 
VMTLFSIKS NHPGLLSEK AASKINETM LRLGIFGFL AFGFVLITF 
SCHFYDFFN QAEWERSFR DYVLCQANV TIGDCEIKN RPSLLVEKI 
NLFAMFGTG IAMSTWVWT


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainB
ProteinG Protein β Sub unit
UniProtP62873
Sequence
>6XBL_Chain_B
DQLRQEAEQ LKNQIRDAR KACADATLS QITNNIDPV GRIQMRTRR 
TLRGHLAKI YAMHWGTDS RLLVSASQD GKLIIWDSY TTNKVHAIP 
LRSSWVMTC AYAPSGNYV ACGGLDNIC SIYNLKTRE GNVRVSREL 
AGHTGYLSC CRFLDDNQI VTSSGDTTC ALWDIETGQ QTTTFTGHT 
GDVMSLSLA PDTRLFVSG ACDASAKLW DVREGMCRQ TFTGHESDI 
NAICFFPNG NAFATGSDD ATCRLFDLR ADQELMTYS HDNIICGIT 
SVSFSKSGR LLLAGYDDF NCNVWDALK ADRAGVLAG HDNRVSCLG 
VTDDGMAVA TGSWDSFLK IWN


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  



This network is also present in following consensuses:
IdComponents
smo_on_allo6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
gi_frizzled6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
4JKVFProteinFrizzledSMOHomo sapiensTaladegib (LY2940680)--2.452013-04-2410.1038/nature12167
4N4WFProteinFrizzledSMOHomo sapiens-SANT-1-2.82014-01-2210.1038/ncomms5355
4O9RFProteinFrizzledSMOHomo sapiensCyclopamine--3.22014-03-0510.1038/ncomms4309
4QIMFProteinFrizzledSMOHomo sapiensPubChem 24905375--2.612014-07-2310.1038/ncomms5355
4QINFProteinFrizzledSMOHomo sapiensSAG1.5--2.62014-07-2310.1038/ncomms5355
5L7DFProteinFrizzledSMOHomo sapiens-Cholesterol-3.22016-07-2010.1038/nature18934
5L7IFProteinFrizzledSMOHomo sapiensVismodegib--3.32016-07-2010.1038/nature18934
5V56FProteinFrizzledSMOHomo sapiensTC114--2.92017-05-2410.1038/ncomms15383
5V57FProteinFrizzledSMOHomo sapiensTC114--32017-05-2410.1038/ncomms15383
6D32FProteinFrizzledSMOXenopus laevisCyclopamineCyclopamine-3.752018-05-2310.1016/j.cell.2018.04.029
6D35FProteinFrizzledSMOXenopus laevis-Cholesterol-3.92018-05-2310.1016/j.cell.2018.04.029
6O3CFProteinFrizzledSMOMus musculusSAG21kCholesterol-2.82019-07-0310.1038/s41586-019-1355-4
6OT0FProteinFrizzledSMOHomo sapiens-25(S)-EpoxycholesterolGi1/&β;1/&γ;23.842019-06-1210.1038/s41586-019-1286-0
6XBJFProteinFrizzledSMOHomo sapiens-CholesterolGi1/&β;1/&γ;23.882020-09-3010.1038/s41589-020-0646-2
6XBKFProteinFrizzledSMOHomo sapiens-CholesterolGi1/&β;1/&γ;23.242020-09-3010.1038/s41589-020-0646-2
6XBLFProteinFrizzledSMOHomo sapiensSAGCholesterolGi1/&β;1/&γ;23.962020-09-3010.1038/s41589-020-0646-2
6XBMFProteinFrizzledSMOHomo sapiens-25(S)-EpoxycholesterolGi1/&β;1/&γ;23.142020-09-3010.1038/s41589-020-0646-2
7ZI0FProteinFrizzledSMOHomo sapiensSAGCholesterol-32022-06-1510.1126/sciadv.abm5563
8CXOFProteinFrizzledSMOMus musculus---3.72022-08-0310.1038/s41467-022-32125-2
4JKV (Dimer)FProteinFrizzledSMOHomo sapiensTaladegib (LY2940680)--2.452013-04-2410.1038/nature12167




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