psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:G191	R:R:R199	9.01	No	No	0	5	4
2	R:R:C193	R:R:R199	6.96	No	No	0	9	4
3	R:R:C193	R:R:C213	7.28	No	No	0	9	9
4	R:R:A492	R:R:E194	7.54	No	No	0	5	6
5	R:R:P196	R:R:Q216	6.32	No	No	0	7	7
6	R:R:P196	R:R:P220	7.79	No	No	0	7	8
7	R:R:P196	R:R:Q491	9.47	No	No	0	7	4
8	R:R:G212	R:R:R199	7.51	No	No	0	7	4
9	R:R:D298	R:R:T200	10.12	Yes	No	0	7	6
10	R:R:N202	R:R:P203	6.52	No	No	0	5	4
11	R:R:K204	R:R:N202	4.2	No	No	0	3	5
12	R:R:N202	R:R:S205	8.94	No	Yes	0	5	7
13	R:R:P203	R:R:W206	5.4	No	No	0	4	4
14	R:R:R296	R:R:S205	6.59	Yes	Yes	5	6	7
15	R:R:D298	R:R:S205	5.89	Yes	Yes	5	7	7
16	R:R:S205	R:R:T300	4.8	Yes	Yes	5	7	7
17	R:R:E211	R:R:W206	7.63	No	No	0	5	4
18	R:R:G212	R:R:W206	8.44	No	No	0	7	4
19	R:R:E208	R:R:Y207	5.61	No	Yes	0	4	7
20	R:R:I215	R:R:Y207	7.25	No	Yes	0	5	7
21	R:R:V488	R:R:Y207	5.05	No	Yes	0	6	7
22	R:R:C213	R:R:V210	5.12	No	No	0	9	5
23	R:R:Q216	R:R:Q218	3.84	No	Yes	0	7	5
24	R:R:C217	R:R:V294	3.42	No	No	0	9	8
25	R:R:C217	R:R:C295	7.28	No	No	0	9	9
26	R:R:H227	R:R:Q218	7.42	No	Yes	1	7	5
27	R:R:Q218	R:R:R291	3.5	Yes	No	0	5	5
28	R:R:Q218	R:R:S385	4.33	Yes	No	1	5	7
29	R:R:N219	R:R:P220	4.89	Yes	No	0	7	8
30	R:R:L221	R:R:N219	4.12	No	Yes	0	6	7
31	R:R:F222	R:R:N219	8.46	Yes	Yes	1	6	7
32	R:R:D384	R:R:N219	5.39	Yes	Yes	1	8	7
33	R:R:N219	R:R:V386	4.43	Yes	Yes	1	7	5
34	R:R:F484	R:R:P220	4.33	No	No	0	6	8
35	R:R:F484	R:R:L221	7.31	No	No	0	6	6
36	R:R:L221	R:R:Y487	4.69	No	No	0	6	4
37	R:R:E226	R:R:F222	10.49	Yes	Yes	1	8	6
38	R:R:F222	R:R:V386	3.93	Yes	Yes	1	6	5
39	R:R:F222	R:R:R512	17.1	Yes	No	1	6	6
40	R:R:F222	R:R:L515	8.53	Yes	No	1	6	5
41	R:R:E226	R:R:T223	5.64	Yes	No	0	8	5
42	R:R:E224	R:R:Q228	6.37	No	No	0	4	3
43	R:R:E226	R:R:R512	10.47	Yes	No	1	8	6
44	R:R:E226	R:R:L515	6.63	Yes	No	1	8	5
45	R:R:H227	R:R:S385	5.58	No	No	1	7	7
46	R:R:H227	R:R:V386	4.15	No	Yes	1	7	5
47	R:R:D229	R:R:K519	6.91	No	No	0	6	7
48	R:R:I234	R:R:M230	4.37	No	No	0	7	7
49	R:R:E518	R:R:M230	4.06	No	No	0	7	7
50	R:R:K519	R:R:M230	4.32	No	No	0	7	7
51	R:R:H231	R:R:Q284	3.71	No	Yes	6	7	9
52	R:R:H231	R:R:R290	19.18	No	No	6	7	9
53	R:R:F237	R:R:Y233	11.35	No	No	0	4	6
54	R:R:K519	R:R:Y233	22.69	No	No	0	7	6
55	R:R:L522	R:R:Y233	3.52	No	No	0	7	6
56	R:R:F285	R:R:I234	3.77	Yes	No	0	8	7
57	R:R:A235	R:R:F285	5.55	No	Yes	0	5	8
58	R:R:F237	R:R:F523	8.57	No	No	0	4	6
59	R:R:F237	R:R:F526	9.65	No	Yes	0	4	9
60	R:R:G238	R:R:L282	3.42	No	No	0	7	7
61	R:R:F526	R:R:G238	4.52	Yes	No	0	9	7
62	R:R:S278	R:R:T241	4.8	No	No	0	8	7
63	R:R:F526	R:R:T241	7.78	Yes	No	0	9	7
64	R:R:I530	R:R:T241	7.6	No	No	0	7	7
65	R:R:G242	R:R:S278	3.71	No	No	0	4	8
66	R:R:C244	R:R:I530	4.91	No	No	0	6	7
67	R:R:C244	R:R:S533	6.89	No	No	0	6	9
68	R:R:N271	R:R:T245	4.39	No	No	0	9	8
69	R:R:S533	R:R:T245	4.8	No	No	0	9	8
70	R:R:F275	R:R:L246	8.53	No	No	0	5	6
71	R:R:F247	R:R:T251	3.89	No	Yes	10	8	9
72	R:R:F247	R:R:W545	9.02	No	Yes	10	8	9
73	R:R:N271	R:R:T248	5.85	No	No	0	9	8
74	R:R:T248	R:R:V536	7.93	No	No	0	8	8
75	R:R:F268	R:R:L249	6.09	Yes	No	0	8	6
76	R:R:T251	R:R:V536	12.69	Yes	No	0	9	8
77	R:R:T251	R:R:W545	9.7	Yes	Yes	10	9	9
78	R:R:F252	R:R:V265	3.93	Yes	No	0	9	8
79	R:R:F252	R:R:F268	18.22	Yes	Yes	0	9	8
80	R:R:F252	R:R:V536	3.93	Yes	No	0	9	8
81	R:R:D255	R:R:N258	13.46	No	No	0	8	8
82	R:R:N260	R:R:W256	23.73	No	No	0	7	7
83	R:R:F268	R:R:W256	7.02	Yes	No	0	8	7
84	R:R:P263	R:R:Y262	4.17	No	Yes	0	9	9
85	R:R:L353	R:R:Y262	4.69	Yes	Yes	7	8	9
86	R:R:T357	R:R:Y262	8.74	No	Yes	0	6	9
87	R:R:F360	R:R:Y262	8.25	Yes	Yes	7	9	9
88	R:R:I266	R:R:V334	4.61	No	No	0	8	7
89	R:R:I266	R:R:L335	5.71	No	Yes	0	8	8
90	R:R:L267	R:R:L335	8.3	Yes	Yes	0	8	8
91	R:R:F455	R:R:L267	3.65	Yes	Yes	4	8	8
92	R:R:L267	R:R:M532	4.24	Yes	Yes	4	8	8
93	R:R:L267	R:R:W535	7.97	Yes	Yes	4	8	9
94	R:R:F268	R:R:Y269	6.19	Yes	No	0	8	8
95	R:R:W331	R:R:Y269	21.22	Yes	No	8	9	8
96	R:R:H361	R:R:Y269	9.8	No	No	8	9	8
97	R:R:A327	R:R:C273	3.61	No	No	0	9	9
98	R:R:C273	R:R:G328	3.92	No	No	0	9	8
99	R:R:F274	R:R:T528	9.08	No	No	0	9	7
100	R:R:F274	R:R:G529	7.53	No	No	0	9	9
101	R:R:F275	R:R:I279	7.54	No	No	0	5	5
102	R:R:V321	R:R:W281	8.58	No	Yes	2	8	7
103	R:R:I389	R:R:W281	14.09	No	Yes	2	9	7
104	R:R:L522	R:R:W281	5.69	No	Yes	2	7	7
105	R:R:M525	R:R:W281	10.47	No	Yes	2	5	7
106	R:R:F526	R:R:W281	4.01	Yes	Yes	2	9	7
107	R:R:F285	R:R:Q284	15.23	Yes	Yes	6	8	9
108	R:R:Q284	R:R:R290	7.01	Yes	No	6	9	9
109	R:R:G388	R:R:Q284	4.93	No	Yes	0	9	9
110	R:R:F285	R:R:R290	6.41	Yes	No	6	8	9
111	R:R:C295	R:R:R291	9.75	No	No	0	9	5
112	R:R:I293	R:R:I317	4.42	No	No	0	8	7
113	R:R:D298	R:R:R296	4.76	Yes	Yes	5	7	6
114	R:R:R296	R:R:T300	6.47	Yes	Yes	5	6	7
115	R:R:F303	R:R:R296	14.97	No	Yes	0	3	6
116	R:R:E310	R:R:R296	8.14	No	Yes	0	8	6
117	R:R:D298	R:R:T300	13.01	Yes	Yes	5	7	7
118	R:R:E305	R:R:R302	3.49	Yes	No	0	7	6
119	R:R:R302	R:R:T311	3.88	No	No	0	6	7
120	R:R:F303	R:R:K395	7.44	No	No	0	3	3
121	R:R:E305	R:R:T307	5.64	Yes	No	0	7	6
122	R:R:E305	R:R:E310	5.07	Yes	No	0	7	8
123	R:R:C314	R:R:E305	4.56	No	Yes	0	9	7
124	R:R:S309	R:R:T307	6.4	No	No	0	6	6
125	R:R:S313	R:R:T311	4.8	No	No	0	7	7
126	R:R:C314	R:R:C390	7.28	No	No	0	9	9
127	R:R:F318	R:R:V319	3.93	Yes	No	0	9	7
128	R:R:F318	R:R:Y322	7.22	Yes	Yes	9	9	9
129	R:R:F318	R:R:I375	10.05	Yes	Yes	9	9	7
130	R:R:F318	R:R:L376	3.65	Yes	No	0	9	8
131	R:R:F318	R:R:V381	15.73	Yes	No	0	9	8
132	R:R:F318	R:R:V392	3.93	Yes	No	9	9	9
133	R:R:I389	R:R:V321	4.61	No	No	2	9	8
134	R:R:M326	R:R:Y322	13.17	No	Yes	0	8	9
135	R:R:L371	R:R:Y322	5.86	No	Yes	0	8	9
136	R:R:I375	R:R:Y322	7.25	Yes	Yes	9	7	9
137	R:R:W365	R:R:Y323	7.72	No	Yes	0	9	8
138	R:R:P368	R:R:Y323	8.34	No	Yes	0	9	8
139	R:R:M326	R:R:P407	6.71	No	No	0	8	9
140	R:R:V329	R:R:V411	4.81	No	No	0	6	5
141	R:R:T364	R:R:V330	6.35	No	No	0	9	6
142	R:R:V334	R:R:W331	3.68	No	Yes	0	7	9
143	R:R:H361	R:R:W331	6.35	No	Yes	8	9	9
144	R:R:T364	R:R:W331	12.13	No	Yes	0	9	9
145	R:R:W331	R:R:W365	9.37	Yes	No	8	9	9
146	R:R:F332	R:R:T336	3.89	No	Yes	0	9	7
147	R:R:F332	R:R:F460	5.36	No	Yes	0	9	5
148	R:R:V333	R:R:V414	4.81	No	No	0	9	5
149	R:R:F360	R:R:V334	6.55	Yes	No	0	9	7
150	R:R:G415	R:R:T336	5.46	No	Yes	0	8	7
151	R:R:F418	R:R:T336	5.19	Yes	Yes	0	8	7
152	R:R:L419	R:R:T336	7.37	No	Yes	0	7	7
153	R:R:T341	R:R:Y337	7.49	No	Yes	0	6	7
154	R:R:L353	R:R:Y337	5.86	Yes	Yes	7	8	7
155	R:R:F360	R:R:Y337	4.13	Yes	Yes	7	9	7
156	R:R:F418	R:R:Y337	15.47	Yes	Yes	0	8	7
157	R:R:F343	R:R:W339	6.01	Yes	Yes	0	9	9
158	R:R:G422	R:R:W339	4.22	No	Yes	0	8	9
159	R:R:L452	R:R:W339	7.97	No	Yes	0	8	9
160	R:R:G453	R:R:W339	9.85	No	Yes	0	5	9
161	R:R:H340	R:R:R421	14.67	No	No	0	7	7
162	R:R:F343	R:R:T425	10.38	Yes	No	0	9	7
163	R:R:F343	R:R:L426	6.09	Yes	No	0	9	9
164	R:R:F343	R:R:M449	3.73	Yes	No	0	9	9
165	R:R:P352	R:R:Y350	6.95	Yes	No	0	7	7
166	R:R:P352	R:R:Q351	7.9	Yes	No	0	7	7
167	R:R:Q351	R:R:S354	4.33	No	No	0	7	7
168	R:R:K356	R:R:L353	4.23	No	Yes	0	8	8
169	R:R:F360	R:R:L353	7.31	Yes	Yes	7	9	8
170	R:R:L363	R:R:Y359	5.86	No	No	0	4	7
171	R:R:H361	R:R:W365	7.41	No	No	8	9	9
172	R:R:F369	R:R:V373	6.55	No	No	0	7	7
173	R:R:I375	R:R:V392	4.61	Yes	No	9	7	9
174	R:R:F403	R:R:I375	12.56	No	Yes	0	8	7
175	R:R:Q380	R:R:V378	4.3	No	No	3	7	5
176	R:R:V378	R:R:Y399	3.79	No	No	3	5	5
177	R:R:Q380	R:R:Y399	29.31	No	No	3	7	5
178	R:R:C390	R:R:V381	3.42	No	No	0	9	8
179	R:R:D382	R:R:Y394	4.6	No	Yes	0	9	5
180	R:R:D382	R:R:K395	8.3	No	No	0	9	3
181	R:R:C390	R:R:G383	3.92	No	No	0	9	8
182	R:R:D384	R:R:V386	8.76	Yes	Yes	1	8	5
183	R:R:D384	R:R:S387	4.42	Yes	No	1	8	8
184	R:R:D384	R:R:Y394	16.09	Yes	Yes	1	8	5
185	R:R:S387	R:R:Y394	3.82	No	Yes	1	8	5
186	R:R:F391	R:R:Y394	4.13	No	Yes	0	8	5
187	R:R:F391	R:R:V404	5.24	No	No	0	8	7
188	R:R:G393	R:R:V392	3.68	No	No	0	9	9
189	R:R:R400	R:R:Y394	4.12	No	Yes	0	9	5
190	R:R:N396	R:R:Y397	3.49	No	Yes	3	7	3
191	R:R:N396	R:R:R398	6.03	No	No	3	7	1
192	R:R:N396	R:R:Y399	6.98	No	No	3	7	5
193	R:R:R398	R:R:Y397	15.43	No	Yes	3	1	3
194	R:R:F474	R:R:Y397	4.13	No	Yes	0	6	3
195	R:R:E481	R:R:Y397	7.86	No	Yes	0	5	3
196	R:R:H470	R:R:R400	6.77	No	No	0	7	9
197	R:R:A401	R:R:F474	4.16	No	No	0	6	6
198	R:R:H470	R:R:V404	6.92	No	No	0	7	7
199	R:R:F467	R:R:L405	6.09	Yes	No	0	7	8
200	R:R:F471	R:R:L405	3.65	No	No	0	4	8
201	R:R:F474	R:R:L405	3.65	No	No	0	6	8
202	R:R:F467	R:R:G409	4.52	Yes	No	0	7	4
203	R:R:F460	R:R:L412	4.87	Yes	Yes	0	5	7
204	R:R:L412	R:R:V463	5.96	Yes	No	0	7	7
205	R:R:F467	R:R:L412	4.87	Yes	Yes	0	7	7
206	R:R:F418	R:R:V414	3.93	Yes	No	0	8	5
207	R:R:F418	R:R:Y417	5.16	Yes	No	0	8	5
208	R:R:R421	R:R:Y417	7.2	No	No	0	7	5
209	R:R:F460	R:R:L419	3.65	Yes	No	0	5	7
210	R:R:F427	R:R:V423	3.93	No	No	0	7	7
211	R:R:H433	R:R:L436	15.43	No	No	0	8	6
212	R:R:G435	R:R:L437	5.13	No	No	0	5	6
213	R:R:L437	R:R:N446	4.12	No	No	0	6	7
214	R:R:L450	R:R:N446	8.24	No	No	0	6	7
215	R:R:E447	R:R:W535	7.63	No	Yes	0	6	9
216	R:R:F455	R:R:R451	6.41	Yes	No	4	8	9
217	R:R:R451	R:R:W535	11	No	Yes	4	9	9
218	R:R:F455	R:R:M532	6.22	Yes	Yes	4	8	8
219	R:R:F455	R:R:T534	6.49	Yes	No	0	8	7
220	R:R:F455	R:R:W535	11.02	Yes	Yes	4	8	9
221	R:R:L458	R:R:M532	4.24	No	Yes	0	6	8
222	R:R:F462	R:R:T528	6.49	No	No	0	7	7
223	R:R:A531	R:R:F462	4.16	No	No	0	6	7
224	R:R:C469	R:R:V517	3.42	No	Yes	0	7	6
225	R:R:C469	R:R:N521	7.87	No	No	0	7	8
226	R:R:H470	R:R:N521	12.75	No	No	0	7	8
227	R:R:D473	R:R:Y472	4.6	No	No	11	8	7
228	R:R:N476	R:R:Y472	9.3	No	No	0	6	7
229	R:R:V517	R:R:Y472	3.79	Yes	No	11	6	7
230	R:R:D473	R:R:V517	5.84	No	Yes	11	8	6
231	R:R:F475	R:R:N476	7.25	No	No	0	3	6
232	R:R:N476	R:R:W480	9.04	No	Yes	0	6	9
233	R:R:Q477	R:R:W480	5.48	No	Yes	0	6	9
234	R:R:E481	R:R:Q477	6.37	No	No	0	5	6
235	R:R:A478	R:R:R482	4.15	No	No	0	3	3
236	R:R:E479	R:R:R482	13.96	No	No	0	2	3
237	R:R:E479	R:R:K510	5.4	No	No	12	2	4
238	R:R:E479	R:R:N511	6.57	No	Yes	12	2	4
239	R:R:N511	R:R:W480	7.91	Yes	Yes	0	4	9
240	R:R:P513	R:R:W480	16.21	No	Yes	0	8	9
241	R:R:N511	R:R:S483	5.96	Yes	No	0	4	7
242	R:R:F484	R:R:V488	7.87	No	No	0	6	6
243	R:R:D486	R:R:R485	10.72	No	No	0	4	5
244	R:R:Q491	R:R:Y487	19.16	No	No	0	4	4
245	R:R:I509	R:R:Y487	8.46	No	No	0	4	4
246	R:R:C490	R:R:C507	7.28	No	No	0	9	9
247	R:R:C507	R:R:Q491	6.1	No	No	0	9	4
248	R:R:K510	R:R:N511	9.79	No	Yes	12	4	4
249	R:R:S514	R:R:V517	4.85	No	Yes	0	7	6
250	R:R:F526	R:R:L522	3.65	Yes	No	2	9	7
251	R:R:F526	R:R:M525	7.46	Yes	No	2	9	5
252	R:R:T534	R:R:W537	13.34	No	No	0	7	8
253	R:R:T538	R:R:T541	4.71	No	No	0	8	8
254	R:R:C550	R:R:R547	9.75	No	No	0	4	6
255	R:R:R551	R:R:T548	3.88	No	No	0	7	6
256	R:R:L552	R:R:W549	7.97	No	No	0	4	5
257	R:R:A324	R:R:V276	3.39	No	No	0	7	5
258	R:R:A524	R:R:T466	3.36	No	No	0	7	8
259	R:R:L376	R:R:P306	3.28	No	No	0	8	5
260	R:R:L367	R:R:P368	3.28	No	No	0	5	9
261	R:R:C469	R:R:I520	3.27	No	No	0	7	5
262	R:R:A524	R:R:I465	3.25	No	No	0	7	5
263	R:R:C217	R:R:M301	3.24	No	No	0	9	4
264	R:R:A459	R:R:M532	3.22	No	Yes	0	7	8
265	R:R:V333	R:R:V411	3.21	No	No	0	9	5
266	R:R:C213	R:R:L197	3.17	No	No	0	9	9
267	R:R:T372	R:R:V319	3.17	No	No	0	9	7
268	R:R:P263	R:R:Q351	3.16	No	No	0	9	7
269	R:R:A531	R:R:L458	3.15	No	No	0	6	6
270	R:R:T251	R:R:T541	3.14	Yes	No	0	9	8
271	R:R:I530	R:R:V240	3.07	No	No	0	7	4
272	R:R:I293	R:R:V294	3.07	No	No	0	8	8
273	R:R:M532	R:R:V270	3.04	Yes	No	0	8	8
274	R:R:F303	R:R:G304	3.01	No	No	0	3	5
275	R:R:F460	R:R:G461	3.01	Yes	No	0	5	5
276	R:R:F462	R:R:G527	3.01	No	No	0	7	5
277	R:R:N432	R:R:S431	2.98	No	No	0	6	5
278	R:R:N521	R:R:T466	2.92	No	No	0	8	8
279	R:R:N493	R:R:T495	2.92	No	No	0	5	4
280	R:R:Q216	R:R:V198	2.87	No	No	0	7	6
281	R:R:E194	R:R:V494	2.85	No	No	0	6	5
282	R:R:I316	R:R:L312	2.85	No	No	0	5	7
283	R:R:I520	R:R:L516	2.85	No	No	0	5	4
284	R:R:L346	R:R:M449	2.83	No	No	0	6	9
285	R:R:K430	R:R:L426	2.82	No	No	0	8	9
286	R:R:L335	R:R:L452	2.77	Yes	No	0	8	8
287	R:R:L346	R:R:L436	2.77	No	No	0	6	6
288	R:R:A374	R:R:F403	2.77	No	No	0	5	8
289	R:R:L412	R:R:L464	2.77	Yes	No	0	7	4
290	R:R:L426	R:R:L450	2.77	No	No	0	9	6
291	R:R:A327	R:R:Y323	2.67	No	Yes	0	9	8
292	R:R:F252	R:R:S259	2.64	Yes	No	0	9	8
293	R:R:F268	R:R:V253	2.62	Yes	No	0	8	5
294	R:R:F275	R:R:T245	2.59	No	No	0	5	8
295	R:R:A250	R:R:W545	2.59	No	Yes	0	6	9
296	R:R:E194	R:R:Q192	2.55	No	No	0	6	4
297	R:R:F343	R:R:I429	2.51	Yes	No	0	9	7
298	R:R:F467	R:R:I408	2.51	Yes	No	0	7	7
299	R:R:T348	R:R:Y350	2.5	No	No	0	7	7
300	R:R:M424	R:R:R421	2.48	No	No	0	5	7
301	R:R:S342	R:R:W339	2.47	No	Yes	0	8	9
302	R:R:T548	R:R:W545	2.43	No	Yes	0	6	9
303	R:R:K356	R:R:Y359	2.39	No	No	0	8	7
304	R:R:G415	R:R:G416	2.11	No	No	0	8	5
305	R:R:R485	R:R:Y207	2.06	No	Yes	0	5	7
306	R:R:A324	R:R:G277	1.95	No	No	0	7	6
307	R:R:A401	R:R:G402	1.95	No	No	0	6	5
308	R:R:A406	R:R:G402	1.95	No	No	0	5	5
309	R:R:A379	R:R:P306	1.87	No	No	0	6	5
310	R:R:A345	R:R:P352	1.87	No	Yes	0	7	7
311	R:R:G355	R:R:S354	1.86	No	No	0	6	7
312	R:R:G280	R:R:V321	1.84	No	No	0	7	8
313	R:R:G214	R:R:T300	1.82	No	Yes	0	8	7
314	R:R:P306	R:R:V315	1.77	No	No	0	5	7
315	R:R:G280	R:R:I320	1.76	No	No	0	7	5
316	R:R:G456	R:R:L335	1.71	No	Yes	0	7	8
317	R:R:G456	R:R:L419	1.71	No	No	0	7	7
318	R:R:A225	R:R:T223	1.68	No	No	0	4	5
319	R:R:D298	R:R:G299	1.68	Yes	No	0	7	4
320	R:R:A540	R:R:T538	1.68	No	No	0	8	8
321	R:R:K344	R:R:P352	1.67	No	Yes	0	6	7
322	R:R:A338	R:R:I266	1.62	No	No	0	8	8
323	R:R:A283	R:R:I317	1.62	No	No	0	5	7
324	R:R:A289	R:R:I293	1.62	No	No	0	7	8
325	R:R:S366	R:R:V370	1.62	No	No	0	7	5
326	R:R:A283	R:R:M286	1.61	No	No	0	5	4
327	R:R:A289	R:R:M286	1.61	No	No	0	7	4
328	R:R:A272	R:R:L249	1.58	No	No	0	4	6
329	R:R:T348	R:R:T349	1.57	No	No	0	7	6
330	R:R:I320	R:R:V276	1.54	No	No	0	5	5
331	R:R:H433	R:R:P434	1.53	No	No	0	8	7
332	R:R:I544	R:R:T548	1.52	No	No	0	6	6
333	R:R:A264	R:R:E447	1.51	No	No	0	9	6
334	R:R:A297	R:R:E310	1.51	No	No	0	5	8
335	R:R:N432	R:R:S428	1.49	No	No	0	6	5
336	R:R:I316	R:R:I320	1.47	No	No	0	5	5
337	R:R:D209	R:R:V210	1.46	No	No	0	4	5
338	R:R:I420	R:R:M424	1.46	No	No	0	5	5
339	R:R:L325	R:R:M525	1.41	No	No	0	5	5
340	R:R:E447	R:R:T448	1.41	No	No	0	6	8
341	R:R:K539	R:R:L542	1.41	No	No	0	5	4
342	R:R:C550	R:R:R546	1.39	No	No	0	4	5
343	R:R:E224	R:R:Q218	1.27	No	Yes	0	4	5
344	R:R:F455	R:R:I454	1.26	Yes	No	0	8	6
345	R:R:V423	R:R:W339	1.23	No	Yes	0	7	9
346	R:R:N258	R:R:R257	1.21	No	No	0	8	5
347	R:R:N258	R:R:R261	1.21	No	No	0	8	7
348	R:R:N260	R:R:R261	1.21	No	No	0	7	7
349	R:R:L489	R:R:R485	1.21	No	No	0	4	5
350	R:R:F369	R:R:Y323	1.03	No	Yes	0	7	8
351	R:R:R546	R:R:W549	1	No	No	0	5	5

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	R:R:S205	6.555	4	5	7
2	R:R:Y207	4.9925	4	0	7
3	R:R:Q218	4.072	5	1	5
4	R:R:N219	5.458	5	1	7
5	R:R:F222	9.702	5	1	6
6	R:R:E226	8.3075	4	1	8
7	R:R:T251	7.355	4	10	9
8	R:R:F252	7.18	4	0	9
9	R:R:Y262	6.4625	4	7	9
10	R:R:L267	6.04	4	4	8
11	R:R:F268	8.028	5	0	8
12	R:R:W281	8.568	5	2	7
13	R:R:Q284	7.72	4	6	9
14	R:R:F285	7.74	4	6	8
15	R:R:R296	8.186	5	5	6
16	R:R:D298	7.092	5	5	7
17	R:R:T300	6.525	4	5	7
18	R:R:E305	4.69	4	0	7
19	R:R:F318	7.41833	6	9	9
20	R:R:Y322	8.375	4	9	9
21	R:R:Y323	4.94	4	0	8
22	R:R:W331	10.55	5	8	9
23	R:R:L335	4.6225	4	0	8
24	R:R:T336	5.4775	4	0	7
25	R:R:Y337	8.2375	4	7	7
26	R:R:W339	5.29167	6	0	9
27	R:R:F343	5.744	5	0	9
28	R:R:P352	4.5975	4	0	7
29	R:R:L353	5.5225	4	7	8
30	R:R:F360	6.56	4	7	9
31	R:R:I375	8.6175	4	9	7
32	R:R:D384	8.665	4	1	8
33	R:R:V386	5.3175	4	1	5
34	R:R:Y394	6.552	5	1	5
35	R:R:Y397	7.7275	4	3	3
36	R:R:L412	4.6175	4	0	7
37	R:R:F418	7.4375	4	0	8
38	R:R:F455	5.84167	6	4	8
39	R:R:F460	4.2225	4	0	5
40	R:R:F467	4.4975	4	0	7
41	R:R:W480	9.66	4	0	9
42	R:R:N511	7.5575	4	12	4
43	R:R:V517	4.475	4	11	6
44	R:R:F526	6.17833	6	2	9
45	R:R:M532	4.192	5	4	8
46	R:R:W535	9.405	4	4	9
47	R:R:W545	5.935	4	10	9

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:P203	R:R:W206	10.318	5.4	No	No	0	4	4
2	R:R:N202	R:R:P203	11.3204	6.52	No	No	0	5	4
3	R:R:N202	R:R:S205	13.3093	8.94	No	Yes	0	5	7
4	R:R:R296	R:R:S205	14.0135	6.59	Yes	Yes	5	6	7
5	R:R:F303	R:R:R296	44.4459	14.97	No	Yes	0	3	6
6	R:R:F303	R:R:K395	46.0397	7.44	No	No	0	3	3
7	R:R:D382	R:R:K395	46.8272	8.3	No	No	0	9	3
8	R:R:D382	R:R:Y394	47.6093	4.6	No	Yes	0	9	5
9	R:R:D384	R:R:Y394	53.9038	16.09	Yes	Yes	1	8	5
10	R:R:D384	R:R:N219	31.9241	5.39	Yes	Yes	1	8	7
11	R:R:N219	R:R:P220	13.6829	4.89	Yes	No	0	7	8
12	R:R:D384	R:R:V386	21.3938	8.76	Yes	Yes	1	8	5
13	R:R:H227	R:R:V386	15.6127	4.15	No	Yes	1	7	5
14	R:R:H227	R:R:Q218	13.7152	7.42	No	Yes	1	7	5
15	R:R:L221	R:R:N219	12.8229	4.12	No	Yes	0	6	7
16	R:R:V488	R:R:Y207	11.3984	5.05	No	Yes	0	6	7
17	R:R:F484	R:R:V488	13.3093	7.87	No	No	0	6	6
18	R:R:K519	R:R:Y233	20.3806	22.69	No	No	0	7	6
19	R:R:F237	R:R:Y233	10.834	11.35	No	No	0	4	6
20	R:R:F237	R:R:F526	12.4735	9.65	No	Yes	0	4	9
21	R:R:F526	R:R:T241	35.8293	7.78	Yes	No	0	9	7
22	R:R:I530	R:R:T241	37.8934	7.6	No	No	0	7	7
23	R:R:C244	R:R:I530	39.2426	4.91	No	No	0	6	7
24	R:R:C244	R:R:S533	39.9092	6.89	No	No	0	6	9
25	R:R:S533	R:R:T245	40.5703	4.8	No	No	0	9	8
26	R:R:N271	R:R:T245	43.1612	4.39	No	No	0	9	8
27	R:R:N271	R:R:T248	43.7955	5.85	No	No	0	9	8
28	R:R:T248	R:R:V536	44.4083	7.93	No	No	0	8	8
29	R:R:F252	R:R:V536	50.805	3.93	Yes	No	0	9	8
30	R:R:F252	R:R:F268	52.4337	18.22	Yes	Yes	0	9	8
31	R:R:F268	R:R:Y269	57.5832	6.19	Yes	No	0	8	8
32	R:R:W331	R:R:Y269	55.8739	21.22	Yes	No	8	9	8
33	R:R:V334	R:R:W331	61.7196	3.68	No	Yes	0	7	9
34	R:R:I266	R:R:V334	55.9975	4.61	No	No	0	8	7
35	R:R:I266	R:R:L335	56.4652	5.71	No	Yes	0	8	8
36	R:R:G456	R:R:L335	63.6386	1.71	No	Yes	0	7	8
37	R:R:G456	R:R:L419	63.7084	1.71	No	No	0	7	7
38	R:R:F460	R:R:L419	81.0654	3.65	Yes	No	0	5	7
39	R:R:F460	R:R:L412	100	4.87	Yes	Yes	0	5	7
40	R:R:F467	R:R:L412	99.3792	4.87	Yes	Yes	0	7	7
41	R:R:F467	R:R:L405	98.7099	6.09	Yes	No	0	7	8
42	R:R:F474	R:R:L405	98.2369	3.65	No	No	0	6	8
43	R:R:F474	R:R:Y397	97.2263	4.13	No	Yes	0	6	3
44	R:R:E481	R:R:Y397	95.5492	7.86	No	Yes	0	5	3
45	R:R:E481	R:R:Q477	95.2509	6.37	No	No	0	5	6
46	R:R:Q477	R:R:W480	94.9472	5.48	No	Yes	0	6	9
47	R:R:N476	R:R:W480	92.324	9.04	No	Yes	0	6	9
48	R:R:N476	R:R:Y472	91.6145	9.3	No	No	0	6	7
49	R:R:V517	R:R:Y472	90.5394	3.79	Yes	No	11	6	7
50	R:R:C469	R:R:V517	90.1309	3.42	No	Yes	0	7	6
51	R:R:C469	R:R:N521	88.9618	7.87	No	No	0	7	8
52	R:R:H470	R:R:N521	87.3277	12.75	No	No	0	7	8
53	R:R:H470	R:R:R400	85.4248	6.77	No	No	0	7	9
54	R:R:R400	R:R:Y394	84.9921	4.12	No	Yes	0	9	5
55	R:R:L522	R:R:Y233	11.2183	3.52	No	No	0	7	6
56	R:R:F526	R:R:L522	11.5919	3.65	Yes	No	2	9	7
57	R:R:K519	R:R:M230	17.0371	4.32	No	No	0	7	7
58	R:R:I234	R:R:M230	13.6722	4.37	No	No	0	7	7
59	R:R:F285	R:R:I234	11.9816	3.77	Yes	No	0	8	7
60	R:R:F332	R:R:F460	19.5716	5.36	No	Yes	0	9	5
61	R:R:F332	R:R:T336	19.5125	3.89	No	Yes	0	9	7
62	R:R:F418	R:R:T336	38.1917	5.19	Yes	Yes	0	8	7
63	R:R:F418	R:R:Y337	31.6338	15.47	Yes	Yes	0	8	7
64	R:R:L353	R:R:Y337	14.5215	5.86	Yes	Yes	7	8	7
65	R:R:L353	R:R:Y262	11.0221	4.69	Yes	Yes	7	8	9
66	R:R:P263	R:R:Y262	22.1867	4.17	No	Yes	0	9	9
67	R:R:L419	R:R:T336	20.824	7.37	No	Yes	0	7	7
68	R:R:F360	R:R:Y337	16.1851	4.13	Yes	Yes	7	9	7
69	R:R:F360	R:R:Y262	15.446	8.25	Yes	Yes	7	9	9
70	R:R:L267	R:R:L335	17.701	8.3	Yes	Yes	0	8	8
71	R:R:E310	R:R:R296	27.5405	8.14	No	Yes	0	8	6
72	R:R:E305	R:R:E310	25.7129	5.07	Yes	No	0	7	8
73	R:R:C314	R:R:E305	20.1011	4.56	No	Yes	0	9	7
74	R:R:C314	R:R:C390	19.1469	7.28	No	No	0	9	9
75	R:R:F318	R:R:V381	16.2523	15.73	Yes	No	0	9	8
76	R:R:C390	R:R:V381	17.2226	3.42	No	No	0	9	8
77	R:R:F343	R:R:W339	12.1133	6.01	Yes	Yes	0	9	9
78	R:R:L452	R:R:W339	17.0076	7.97	No	Yes	0	8	9
79	R:R:L335	R:R:L452	17.7789	2.77	Yes	No	0	8	8
80	R:R:P263	R:R:Q351	19.9747	3.16	No	No	0	9	7
81	R:R:P352	R:R:Q351	13.4625	7.9	Yes	No	0	7	7
82	R:R:F360	R:R:V334	10.8125	6.55	Yes	No	0	9	7

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

there is no ligand in network 8CXO

PDB Summary
PDB	8CXO
Class	F
SubFamily	Protein
Type	Frizzled
SubType	SMO
Species	Mus musculus
Ligand	-
Other Ligand(s)	-
Protein Partners	-
PDB Resolution	3.7
Date	2022-08-03
D.O.I.	10.1038/s41467-022-32125-2

Net Summary
I_min	3.42
Number of Linked Nodes	322
Number of Links	351
Number of Hubs	47
Number of Links mediated by Hubs	170
Number of Communities	12
Number of Nodes involved in Communities	58
Number of Links involved in Communities	74

Path Summary
Number Of Nodes in MetaPath	83
Number Of Links MetaPath	82
Number of Shortest Paths	65144
Length Of Smallest Path	3
Average Path Length	23.7471
Length of Longest Path	57
Minimum Path Strength	1.195
Average Path Strength	6.63204
Maximum Path Strength	18.145
Minimum Path Correlation	0.7
Average Path Correlation	0.946746
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	2.22222
Average % Of Corr. Nodes	45.5734
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	38.1201
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process
Gene Ontology	Cellular Component
SCOP2	Domain Identifier
SCOP2	Family Identifier
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	Q99835
Sequence	>8CXO_Chain_R G Q C E A P L V R T D N P K S W Y E D V E G C G I Q C Q N P L F T E A E H Q D M H S Y I A A F G A V T G L C T L F T L A T F V A D W R N S N R Y P A V I L F Y V N A C F F V G S I G W L A Q F M D G A R R E I V C R A D G T M R F G E P T S S E T L S C V I I F V I V Y Y A L M A G V V W F V V L T Y A W H T S F K A L G T T Y Q P L S G K T S Y F H L L T W S L P F V L T V A I L A V A Q V D G D S V S G I C F V G Y K N Y R Y R A G F V L A P I G L V L I V G G Y F L I R G V M T L F S I K S N H P G L L N E T M L R L G I F G F L A F G F V L I T F S C H F Y D F F N Q A E W E R S F R D Y V L C Q A N V T D C E I K N R P S L L V E K I N L F A M F G T G I A M S T W V W T K A T L L I W R R T W C R L Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	4JKV	F	Protein	Frizzled	SMO	Homo sapiens	Taladegib (LY2940680)	-	-	2.45	2013-04-24	10.1038/nature12167
	4N4W	F	Protein	Frizzled	SMO	Homo sapiens	-	SANT-1	-	2.8	2014-01-22	10.1038/ncomms5355
	4O9R	F	Protein	Frizzled	SMO	Homo sapiens	Cyclopamine	-	-	3.2	2014-03-05	10.1038/ncomms4309
	4QIM	F	Protein	Frizzled	SMO	Homo sapiens	PubChem 24905375	-	-	2.61	2014-07-23	10.1038/ncomms5355
	4QIN	F	Protein	Frizzled	SMO	Homo sapiens	SAG1.5	-	-	2.6	2014-07-23	10.1038/ncomms5355
	5L7D	F	Protein	Frizzled	SMO	Homo sapiens	-	Cholesterol	-	3.2	2016-07-20	10.1038/nature18934
	5L7I	F	Protein	Frizzled	SMO	Homo sapiens	Vismodegib	-	-	3.3	2016-07-20	10.1038/nature18934
	5V56	F	Protein	Frizzled	SMO	Homo sapiens	TC114	-	-	2.9	2017-05-24	10.1038/ncomms15383
	5V57	F	Protein	Frizzled	SMO	Homo sapiens	TC114	-	-	3	2017-05-24	10.1038/ncomms15383
	6D32	F	Protein	Frizzled	SMO	Xenopus laevis	Cyclopamine	Cyclopamine	-	3.75	2018-05-23	10.1016/j.cell.2018.04.029
	6D35	F	Protein	Frizzled	SMO	Xenopus laevis	-	Cholesterol	-	3.9	2018-05-23	10.1016/j.cell.2018.04.029
	6O3C	F	Protein	Frizzled	SMO	Mus musculus	SAG21k	Cholesterol	-	2.8	2019-07-03	10.1038/s41586-019-1355-4
	6OT0	F	Protein	Frizzled	SMO	Homo sapiens	-	25(S)-Epoxycholesterol	Gi1/&β;1/&γ;2	3.84	2019-06-12	10.1038/s41586-019-1286-0
	6XBJ	F	Protein	Frizzled	SMO	Homo sapiens	-	Cholesterol	Gi1/&β;1/&γ;2	3.88	2020-09-30	10.1038/s41589-020-0646-2
	6XBK	F	Protein	Frizzled	SMO	Homo sapiens	-	Cholesterol	Gi1/&β;1/&γ;2	3.24	2020-09-30	10.1038/s41589-020-0646-2
	6XBL	F	Protein	Frizzled	SMO	Homo sapiens	SAG	Cholesterol	Gi1/&β;1/&γ;2	3.96	2020-09-30	10.1038/s41589-020-0646-2
	6XBM	F	Protein	Frizzled	SMO	Homo sapiens	-	25(S)-Epoxycholesterol	Gi1/&β;1/&γ;2	3.14	2020-09-30	10.1038/s41589-020-0646-2
	7ZI0	F	Protein	Frizzled	SMO	Homo sapiens	SAG	Cholesterol	-	3	2022-06-15	10.1126/sciadv.abm5563
	8CXO	F	Protein	Frizzled	SMO	Mus musculus	-	-	-	3.7	2022-08-03	10.1038/s41467-022-32125-2
	4JKV (Dimer)	F	Protein	Frizzled	SMO	Homo sapiens	Taladegib (LY2940680)	-	-	2.45	2013-04-24	10.1038/nature12167

You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

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