psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:G195	R:R:R203	9.01	No	No	0	5	4
2	R:R:C197	R:R:R203	6.96	No	No	0	9	4
3	R:R:C197	R:R:C217	7.28	No	No	0	9	9
4	R:R:A496	R:R:E198	7.54	No	No	0	5	6
5	R:R:P200	R:R:Q220	6.32	No	No	0	7	7
6	R:R:P200	R:R:P224	7.79	No	No	0	7	8
7	R:R:P200	R:R:Q495	9.47	No	No	0	7	4
8	R:R:G216	R:R:R203	7.51	No	No	0	7	4
9	R:R:D302	R:R:T204	10.12	Yes	No	0	7	6
10	R:R:N206	R:R:P207	6.52	No	No	0	5	4
11	R:R:K208	R:R:N206	4.2	No	No	0	3	5
12	R:R:N206	R:R:S209	8.94	No	Yes	0	5	7
13	R:R:P207	R:R:W210	5.4	No	No	0	4	4
14	R:R:R300	R:R:S209	6.59	Yes	Yes	5	6	7
15	R:R:D302	R:R:S209	5.89	Yes	Yes	5	7	7
16	R:R:S209	R:R:T304	4.8	Yes	Yes	5	7	7
17	R:R:E215	R:R:W210	7.63	No	No	0	5	4
18	R:R:G216	R:R:W210	8.44	No	No	0	7	4
19	R:R:E212	R:R:Y211	5.61	No	Yes	0	4	7
20	R:R:I219	R:R:Y211	7.25	No	Yes	0	5	7
21	R:R:V492	R:R:Y211	5.05	No	Yes	0	6	7
22	R:R:C217	R:R:V214	5.12	No	No	0	9	5
23	R:R:Q220	R:R:Q222	3.84	No	Yes	0	7	5
24	R:R:C221	R:R:V298	3.42	No	No	0	9	8
25	R:R:C221	R:R:C299	7.28	No	No	0	9	9
26	R:R:H231	R:R:Q222	7.42	No	Yes	1	7	5
27	R:R:Q222	R:R:R295	3.5	Yes	No	0	5	5
28	R:R:Q222	R:R:S389	4.33	Yes	No	1	5	7
29	R:R:N223	R:R:P224	4.89	Yes	No	0	7	8
30	R:R:L225	R:R:N223	4.12	No	Yes	0	6	7
31	R:R:F226	R:R:N223	8.46	Yes	Yes	1	6	7
32	R:R:D388	R:R:N223	5.39	Yes	Yes	1	8	7
33	R:R:N223	R:R:V390	4.43	Yes	Yes	1	7	5
34	R:R:F488	R:R:P224	4.33	No	No	0	6	8
35	R:R:F488	R:R:L225	7.31	No	No	0	6	6
36	R:R:L225	R:R:Y491	4.69	No	No	0	6	4
37	R:R:E230	R:R:F226	10.49	Yes	Yes	1	8	6
38	R:R:F226	R:R:V390	3.93	Yes	Yes	1	6	5
39	R:R:F226	R:R:R516	17.1	Yes	No	1	6	6
40	R:R:F226	R:R:L519	8.53	Yes	No	1	6	5
41	R:R:E230	R:R:T227	5.64	Yes	No	0	8	5
42	R:R:E228	R:R:Q232	6.37	No	No	0	4	3
43	R:R:E230	R:R:R516	10.47	Yes	No	1	8	6
44	R:R:E230	R:R:L519	6.63	Yes	No	1	8	5
45	R:R:H231	R:R:S389	5.58	No	No	1	7	7
46	R:R:H231	R:R:V390	4.15	No	Yes	1	7	5
47	R:R:D233	R:R:K523	6.91	No	No	0	6	7
48	R:R:I238	R:R:M234	4.37	No	No	0	7	7
49	R:R:E522	R:R:M234	4.06	No	No	0	7	7
50	R:R:K523	R:R:M234	4.32	No	No	0	7	7
51	R:R:H235	R:R:Q288	3.71	No	Yes	6	7	9
52	R:R:H235	R:R:R294	19.18	No	No	6	7	9
53	R:R:F241	R:R:Y237	11.35	No	No	0	4	6
54	R:R:K523	R:R:Y237	22.69	No	No	0	7	6
55	R:R:L526	R:R:Y237	3.52	No	No	0	7	6
56	R:R:F289	R:R:I238	3.77	Yes	No	0	8	7
57	R:R:A239	R:R:F289	5.55	No	Yes	0	5	8
58	R:R:F241	R:R:F527	8.57	No	No	0	4	6
59	R:R:F241	R:R:F530	9.65	No	Yes	0	4	9
60	R:R:G242	R:R:L286	3.42	No	No	0	7	7
61	R:R:F530	R:R:G242	4.52	Yes	No	0	9	7
62	R:R:S282	R:R:T245	4.8	No	No	0	8	7
63	R:R:F530	R:R:T245	7.78	Yes	No	0	9	7
64	R:R:I534	R:R:T245	7.6	No	No	0	7	7
65	R:R:G246	R:R:S282	3.71	No	No	0	4	8
66	R:R:C248	R:R:I534	4.91	No	No	0	6	7
67	R:R:C248	R:R:S537	6.89	No	No	0	6	9
68	R:R:N275	R:R:T249	4.39	No	No	0	9	8
69	R:R:S537	R:R:T249	4.8	No	No	0	9	8
70	R:R:F279	R:R:L250	8.53	No	No	0	5	6
71	R:R:F251	R:R:T255	3.89	No	Yes	10	8	9
72	R:R:F251	R:R:W549	9.02	No	Yes	10	8	9
73	R:R:N275	R:R:T252	5.85	No	No	0	9	8
74	R:R:T252	R:R:V540	7.93	No	No	0	8	8
75	R:R:F272	R:R:L253	6.09	Yes	No	0	8	6
76	R:R:T255	R:R:V540	12.69	Yes	No	0	9	8
77	R:R:T255	R:R:W549	9.7	Yes	Yes	10	9	9
78	R:R:F256	R:R:V269	3.93	Yes	No	0	9	8
79	R:R:F256	R:R:F272	18.22	Yes	Yes	0	9	8
80	R:R:F256	R:R:V540	3.93	Yes	No	0	9	8
81	R:R:D259	R:R:N262	13.46	No	No	0	8	8
82	R:R:N264	R:R:W260	23.73	No	No	0	7	7
83	R:R:F272	R:R:W260	7.02	Yes	No	0	8	7
84	R:R:P267	R:R:Y266	4.17	No	Yes	0	9	9
85	R:R:L357	R:R:Y266	4.69	Yes	Yes	7	8	9
86	R:R:T361	R:R:Y266	8.74	No	Yes	0	6	9
87	R:R:F364	R:R:Y266	8.25	Yes	Yes	7	9	9
88	R:R:I270	R:R:V338	4.61	No	No	0	8	7
89	R:R:I270	R:R:L339	5.71	No	Yes	0	8	8
90	R:R:L271	R:R:L339	8.3	Yes	Yes	0	8	8
91	R:R:F459	R:R:L271	3.65	Yes	Yes	4	8	8
92	R:R:L271	R:R:M536	4.24	Yes	Yes	4	8	8
93	R:R:L271	R:R:W539	7.97	Yes	Yes	4	8	9
94	R:R:F272	R:R:Y273	6.19	Yes	No	0	8	8
95	R:R:W335	R:R:Y273	21.22	Yes	No	8	9	8
96	R:R:H365	R:R:Y273	9.8	No	No	8	9	8
97	R:R:A331	R:R:C277	3.61	No	No	0	9	9
98	R:R:C277	R:R:G332	3.92	No	No	0	9	8
99	R:R:F278	R:R:T532	9.08	No	No	0	9	7
100	R:R:F278	R:R:G533	7.53	No	No	0	9	9
101	R:R:F279	R:R:I283	7.54	No	No	0	5	5
102	R:R:V325	R:R:W285	8.58	No	Yes	2	8	7
103	R:R:I393	R:R:W285	14.09	No	Yes	2	9	7
104	R:R:L526	R:R:W285	5.69	No	Yes	2	7	7
105	R:R:M529	R:R:W285	10.47	No	Yes	2	5	7
106	R:R:F530	R:R:W285	4.01	Yes	Yes	2	9	7
107	R:R:F289	R:R:Q288	15.23	Yes	Yes	6	8	9
108	R:R:Q288	R:R:R294	7.01	Yes	No	6	9	9
109	R:R:G392	R:R:Q288	4.93	No	Yes	0	9	9
110	R:R:F289	R:R:R294	6.41	Yes	No	6	8	9
111	R:R:C299	R:R:R295	9.75	No	No	0	9	5
112	R:R:I297	R:R:I321	4.42	No	No	0	8	7
113	R:R:D302	R:R:R300	4.76	Yes	Yes	5	7	6
114	R:R:R300	R:R:T304	6.47	Yes	Yes	5	6	7
115	R:R:F307	R:R:R300	14.97	No	Yes	0	3	6
116	R:R:E314	R:R:R300	8.14	No	Yes	0	8	6
117	R:R:D302	R:R:T304	13.01	Yes	Yes	5	7	7
118	R:R:E309	R:R:R306	3.49	Yes	No	0	7	6
119	R:R:R306	R:R:T315	3.88	No	No	0	6	7
120	R:R:F307	R:R:K399	7.44	No	No	0	3	3
121	R:R:E309	R:R:T311	5.64	Yes	No	0	7	6
122	R:R:E309	R:R:E314	5.07	Yes	No	0	7	8
123	R:R:C318	R:R:E309	4.56	No	Yes	0	9	7
124	R:R:S313	R:R:T311	6.4	No	No	0	6	6
125	R:R:S317	R:R:T315	4.8	No	No	0	7	7
126	R:R:C318	R:R:C394	7.28	No	No	0	9	9
127	R:R:F322	R:R:V323	3.93	Yes	No	0	9	7
128	R:R:F322	R:R:Y326	7.22	Yes	Yes	9	9	9
129	R:R:F322	R:R:I379	10.05	Yes	Yes	9	9	7
130	R:R:F322	R:R:L380	3.65	Yes	No	0	9	8
131	R:R:F322	R:R:V385	15.73	Yes	No	0	9	8
132	R:R:F322	R:R:V396	3.93	Yes	No	9	9	9
133	R:R:I393	R:R:V325	4.61	No	No	2	9	8
134	R:R:M330	R:R:Y326	13.17	No	Yes	0	8	9
135	R:R:L375	R:R:Y326	5.86	No	Yes	0	8	9
136	R:R:I379	R:R:Y326	7.25	Yes	Yes	9	7	9
137	R:R:W369	R:R:Y327	7.72	No	Yes	0	9	8
138	R:R:P372	R:R:Y327	8.34	No	Yes	0	9	8
139	R:R:M330	R:R:P411	6.71	No	No	0	8	9
140	R:R:V333	R:R:V415	4.81	No	No	0	6	5
141	R:R:T368	R:R:V334	6.35	No	No	0	9	6
142	R:R:V338	R:R:W335	3.68	No	Yes	0	7	9
143	R:R:H365	R:R:W335	6.35	No	Yes	8	9	9
144	R:R:T368	R:R:W335	12.13	No	Yes	0	9	9
145	R:R:W335	R:R:W369	9.37	Yes	No	8	9	9
146	R:R:F336	R:R:T340	3.89	No	Yes	0	9	7
147	R:R:F336	R:R:F464	5.36	No	Yes	0	9	5
148	R:R:V337	R:R:V418	4.81	No	No	0	9	5
149	R:R:F364	R:R:V338	6.55	Yes	No	0	9	7
150	R:R:G419	R:R:T340	5.46	No	Yes	0	8	7
151	R:R:F422	R:R:T340	5.19	Yes	Yes	0	8	7
152	R:R:L423	R:R:T340	7.37	No	Yes	0	7	7
153	R:R:T345	R:R:Y341	7.49	No	Yes	0	6	7
154	R:R:L357	R:R:Y341	5.86	Yes	Yes	7	8	7
155	R:R:F364	R:R:Y341	4.13	Yes	Yes	7	9	7
156	R:R:F422	R:R:Y341	15.47	Yes	Yes	0	8	7
157	R:R:F347	R:R:W343	6.01	Yes	Yes	0	9	9
158	R:R:G426	R:R:W343	4.22	No	Yes	0	8	9
159	R:R:L456	R:R:W343	7.97	No	Yes	0	8	9
160	R:R:G457	R:R:W343	9.85	No	Yes	0	5	9
161	R:R:H344	R:R:R425	14.67	No	No	0	7	7
162	R:R:F347	R:R:T429	10.38	Yes	No	0	9	7
163	R:R:F347	R:R:L430	6.09	Yes	No	0	9	9
164	R:R:F347	R:R:M453	3.73	Yes	No	0	9	9
165	R:R:P356	R:R:Y354	6.95	Yes	No	0	7	7
166	R:R:P356	R:R:Q355	7.9	Yes	No	0	7	7
167	R:R:Q355	R:R:S358	4.33	No	No	0	7	7
168	R:R:K360	R:R:L357	4.23	No	Yes	0	8	8
169	R:R:F364	R:R:L357	7.31	Yes	Yes	7	9	8
170	R:R:L367	R:R:Y363	5.86	No	No	0	4	7
171	R:R:H365	R:R:W369	7.41	No	No	8	9	9
172	R:R:F373	R:R:V377	6.55	No	No	0	7	7
173	R:R:I379	R:R:V396	4.61	Yes	No	9	7	9
174	R:R:F407	R:R:I379	12.56	No	Yes	0	8	7
175	R:R:Q384	R:R:V382	4.3	No	No	3	7	5
176	R:R:V382	R:R:Y403	3.79	No	No	3	5	5
177	R:R:Q384	R:R:Y403	29.31	No	No	3	7	5
178	R:R:C394	R:R:V385	3.42	No	No	0	9	8
179	R:R:D386	R:R:Y398	4.6	No	Yes	0	9	5
180	R:R:D386	R:R:K399	8.3	No	No	0	9	3
181	R:R:C394	R:R:G387	3.92	No	No	0	9	8
182	R:R:D388	R:R:V390	8.76	Yes	Yes	1	8	5
183	R:R:D388	R:R:S391	4.42	Yes	No	1	8	8
184	R:R:D388	R:R:Y398	16.09	Yes	Yes	1	8	5
185	R:R:S391	R:R:Y398	3.82	No	Yes	1	8	5
186	R:R:F395	R:R:Y398	4.13	No	Yes	0	8	5
187	R:R:F395	R:R:V408	5.24	No	No	0	8	7
188	R:R:G397	R:R:V396	3.68	No	No	0	9	9
189	R:R:R404	R:R:Y398	4.12	No	Yes	0	9	5
190	R:R:N400	R:R:Y401	3.49	No	Yes	3	7	3
191	R:R:N400	R:R:R402	6.03	No	No	3	7	1
192	R:R:N400	R:R:Y403	6.98	No	No	3	7	5
193	R:R:R402	R:R:Y401	15.43	No	Yes	3	1	3
194	R:R:F478	R:R:Y401	4.13	No	Yes	0	6	3
195	R:R:E485	R:R:Y401	7.86	No	Yes	0	5	3
196	R:R:H474	R:R:R404	6.77	No	No	0	7	9
197	R:R:A405	R:R:F478	4.16	No	No	0	6	6
198	R:R:H474	R:R:V408	6.92	No	No	0	7	7
199	R:R:F471	R:R:L409	6.09	Yes	No	0	7	8
200	R:R:F475	R:R:L409	3.65	No	No	0	4	8
201	R:R:F478	R:R:L409	3.65	No	No	0	6	8
202	R:R:F471	R:R:G413	4.52	Yes	No	0	7	4
203	R:R:F464	R:R:L416	4.87	Yes	Yes	0	5	7
204	R:R:L416	R:R:V467	5.96	Yes	No	0	7	7
205	R:R:F471	R:R:L416	4.87	Yes	Yes	0	7	7
206	R:R:F422	R:R:V418	3.93	Yes	No	0	8	5
207	R:R:F422	R:R:Y421	5.16	Yes	No	0	8	5
208	R:R:R425	R:R:Y421	7.2	No	No	0	7	5
209	R:R:F464	R:R:L423	3.65	Yes	No	0	5	7
210	R:R:F431	R:R:V427	3.93	No	No	0	7	7
211	R:R:H437	R:R:L440	15.43	No	No	0	8	6
212	R:R:G439	R:R:L441	5.13	No	No	0	5	6
213	R:R:L441	R:R:N450	4.12	No	No	0	6	7
214	R:R:L454	R:R:N450	8.24	No	No	0	6	7
215	R:R:E451	R:R:W539	7.63	No	Yes	0	6	9
216	R:R:F459	R:R:R455	6.41	Yes	No	4	8	9
217	R:R:R455	R:R:W539	11	No	Yes	4	9	9
218	R:R:F459	R:R:M536	6.22	Yes	Yes	4	8	8
219	R:R:F459	R:R:T538	6.49	Yes	No	0	8	7
220	R:R:F459	R:R:W539	11.02	Yes	Yes	4	8	9
221	R:R:L462	R:R:M536	4.24	No	Yes	0	6	8
222	R:R:F466	R:R:T532	6.49	No	No	0	7	7
223	R:R:A535	R:R:F466	4.16	No	No	0	6	7
224	R:R:C473	R:R:V521	3.42	No	Yes	0	7	6
225	R:R:C473	R:R:N525	7.87	No	No	0	7	8
226	R:R:H474	R:R:N525	12.75	No	No	0	7	8
227	R:R:D477	R:R:Y476	4.6	No	No	11	8	7
228	R:R:N480	R:R:Y476	9.3	No	No	0	6	7
229	R:R:V521	R:R:Y476	3.79	Yes	No	11	6	7
230	R:R:D477	R:R:V521	5.84	No	Yes	11	8	6
231	R:R:F479	R:R:N480	7.25	No	No	0	3	6
232	R:R:N480	R:R:W484	9.04	No	Yes	0	6	9
233	R:R:Q481	R:R:W484	5.48	No	Yes	0	6	9
234	R:R:E485	R:R:Q481	6.37	No	No	0	5	6
235	R:R:A482	R:R:R486	4.15	No	No	0	3	3
236	R:R:E483	R:R:R486	13.96	No	No	0	2	3
237	R:R:E483	R:R:K514	5.4	No	No	12	2	4
238	R:R:E483	R:R:N515	6.57	No	Yes	12	2	4
239	R:R:N515	R:R:W484	7.91	Yes	Yes	0	4	9
240	R:R:P517	R:R:W484	16.21	No	Yes	0	8	9
241	R:R:N515	R:R:S487	5.96	Yes	No	0	4	7
242	R:R:F488	R:R:V492	7.87	No	No	0	6	6
243	R:R:D490	R:R:R489	10.72	No	No	0	4	5
244	R:R:Q495	R:R:Y491	19.16	No	No	0	4	4
245	R:R:I513	R:R:Y491	8.46	No	No	0	4	4
246	R:R:C494	R:R:C511	7.28	No	No	0	9	9
247	R:R:C511	R:R:Q495	6.1	No	No	0	9	4
248	R:R:K514	R:R:N515	9.79	No	Yes	12	4	4
249	R:R:S518	R:R:V521	4.85	No	Yes	0	7	6
250	R:R:F530	R:R:L526	3.65	Yes	No	2	9	7
251	R:R:F530	R:R:M529	7.46	Yes	No	2	9	5
252	R:R:T538	R:R:W541	13.34	No	No	0	7	8
253	R:R:T542	R:R:T545	4.71	No	No	0	8	8
254	R:R:C554	R:R:R551	9.75	No	No	0	4	6
255	R:R:R555	R:R:T552	3.88	No	No	0	7	6
256	R:R:L556	R:R:W553	7.97	No	No	0	4	5
257	R:R:A328	R:R:V280	3.39	No	No	0	7	5
258	R:R:A528	R:R:T470	3.36	No	No	0	7	8
259	R:R:L380	R:R:P310	3.28	No	No	0	8	5
260	R:R:L371	R:R:P372	3.28	No	No	0	5	9
261	R:R:C473	R:R:I524	3.27	No	No	0	7	5
262	R:R:A528	R:R:I469	3.25	No	No	0	7	5
263	R:R:C221	R:R:M305	3.24	No	No	0	9	4
264	R:R:A463	R:R:M536	3.22	No	Yes	0	7	8
265	R:R:V337	R:R:V415	3.21	No	No	0	9	5
266	R:R:C217	R:R:L201	3.17	No	No	0	9	9
267	R:R:T376	R:R:V323	3.17	No	No	0	9	7
268	R:R:P267	R:R:Q355	3.16	No	No	0	9	7
269	R:R:A535	R:R:L462	3.15	No	No	0	6	6
270	R:R:T255	R:R:T545	3.14	Yes	No	0	9	8
271	R:R:I534	R:R:V244	3.07	No	No	0	7	4
272	R:R:I297	R:R:V298	3.07	No	No	0	8	8
273	R:R:M536	R:R:V274	3.04	Yes	No	0	8	8
274	R:R:F307	R:R:G308	3.01	No	No	0	3	5
275	R:R:F464	R:R:G465	3.01	Yes	No	0	5	5
276	R:R:F466	R:R:G531	3.01	No	No	0	7	5
277	R:R:N436	R:R:S435	2.98	No	No	0	6	5
278	R:R:N525	R:R:T470	2.92	No	No	0	8	8
279	R:R:N497	R:R:T499	2.92	No	No	0	5	4
280	R:R:Q220	R:R:V202	2.87	No	No	0	7	6
281	R:R:E198	R:R:V498	2.85	No	No	0	6	5
282	R:R:I320	R:R:L316	2.85	No	No	0	5	7
283	R:R:I524	R:R:L520	2.85	No	No	0	5	4
284	R:R:L350	R:R:M453	2.83	No	No	0	6	9
285	R:R:K434	R:R:L430	2.82	No	No	0	8	9
286	R:R:L339	R:R:L456	2.77	Yes	No	0	8	8
287	R:R:L350	R:R:L440	2.77	No	No	0	6	6
288	R:R:A378	R:R:F407	2.77	No	No	0	5	8
289	R:R:L416	R:R:L468	2.77	Yes	No	0	7	4
290	R:R:L430	R:R:L454	2.77	No	No	0	9	6
291	R:R:A331	R:R:Y327	2.67	No	Yes	0	9	8
292	R:R:F256	R:R:S263	2.64	Yes	No	0	9	8
293	R:R:F272	R:R:V257	2.62	Yes	No	0	8	5
294	R:R:F279	R:R:T249	2.59	No	No	0	5	8
295	R:R:A254	R:R:W549	2.59	No	Yes	0	6	9
296	R:R:E198	R:R:Q196	2.55	No	No	0	6	4
297	R:R:F347	R:R:I433	2.51	Yes	No	0	9	7
298	R:R:F471	R:R:I412	2.51	Yes	No	0	7	7
299	R:R:T352	R:R:Y354	2.5	No	No	0	7	7
300	R:R:M428	R:R:R425	2.48	No	No	0	5	7
301	R:R:S346	R:R:W343	2.47	No	Yes	0	8	9
302	R:R:T552	R:R:W549	2.43	No	Yes	0	6	9
303	R:R:K360	R:R:Y363	2.39	No	No	0	8	7
304	R:R:G419	R:R:G420	2.11	No	No	0	8	5
305	R:R:R489	R:R:Y211	2.06	No	Yes	0	5	7
306	R:R:A328	R:R:G281	1.95	No	No	0	7	6
307	R:R:A405	R:R:G406	1.95	No	No	0	6	5
308	R:R:A410	R:R:G406	1.95	No	No	0	5	5
309	R:R:A383	R:R:P310	1.87	No	No	0	6	5
310	R:R:A349	R:R:P356	1.87	No	Yes	0	7	7
311	R:R:G359	R:R:S358	1.86	No	No	0	6	7
312	R:R:G284	R:R:V325	1.84	No	No	0	7	8
313	R:R:G218	R:R:T304	1.82	No	Yes	0	8	7
314	R:R:P310	R:R:V319	1.77	No	No	0	5	7
315	R:R:G284	R:R:I324	1.76	No	No	0	7	5
316	R:R:G460	R:R:L339	1.71	No	Yes	0	7	8
317	R:R:G460	R:R:L423	1.71	No	No	0	7	7
318	R:R:A229	R:R:T227	1.68	No	No	0	4	5
319	R:R:D302	R:R:G303	1.68	Yes	No	0	7	4
320	R:R:A544	R:R:T542	1.68	No	No	0	8	8
321	R:R:K348	R:R:P356	1.67	No	Yes	0	6	7
322	R:R:A342	R:R:I270	1.62	No	No	0	8	8
323	R:R:A287	R:R:I321	1.62	No	No	0	5	7
324	R:R:A293	R:R:I297	1.62	No	No	0	7	8
325	R:R:S370	R:R:V374	1.62	No	No	0	7	5
326	R:R:A287	R:R:M290	1.61	No	No	0	5	4
327	R:R:A293	R:R:M290	1.61	No	No	0	7	4
328	R:R:A276	R:R:L253	1.58	No	No	0	4	6
329	R:R:T352	R:R:T353	1.57	No	No	0	7	6
330	R:R:I324	R:R:V280	1.54	No	No	0	5	5
331	R:R:H437	R:R:P438	1.53	No	No	0	8	7
332	R:R:I548	R:R:T552	1.52	No	No	0	6	6
333	R:R:A268	R:R:E451	1.51	No	No	0	9	6
334	R:R:A301	R:R:E314	1.51	No	No	0	5	8
335	R:R:N436	R:R:S432	1.49	No	No	0	6	5
336	R:R:I320	R:R:I324	1.47	No	No	0	5	5
337	R:R:D213	R:R:V214	1.46	No	No	0	4	5
338	R:R:I424	R:R:M428	1.46	No	No	0	5	5
339	R:R:L329	R:R:M529	1.41	No	No	0	5	5
340	R:R:E451	R:R:T452	1.41	No	No	0	6	8
341	R:R:K543	R:R:L546	1.41	No	No	0	5	4
342	R:R:C554	R:R:R550	1.39	No	No	0	4	5
343	R:R:E228	R:R:Q222	1.27	No	Yes	0	4	5
344	R:R:F459	R:R:I458	1.26	Yes	No	0	8	6
345	R:R:V427	R:R:W343	1.23	No	Yes	0	7	9
346	R:R:N262	R:R:R261	1.21	No	No	0	8	5
347	R:R:N262	R:R:R265	1.21	No	No	0	8	7
348	R:R:N264	R:R:R265	1.21	No	No	0	7	7
349	R:R:L493	R:R:R489	1.21	No	No	0	4	5
350	R:R:F373	R:R:Y327	1.03	No	Yes	0	7	8
351	R:R:R550	R:R:W553	1	No	No	0	5	5

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	R:R:S209	6.555	4	5	7
2	R:R:Y211	4.9925	4	0	7
3	R:R:Q222	4.072	5	1	5
4	R:R:N223	5.458	5	1	7
5	R:R:F226	9.702	5	1	6
6	R:R:E230	8.3075	4	1	8
7	R:R:T255	7.355	4	10	9
8	R:R:F256	7.18	4	0	9
9	R:R:Y266	6.4625	4	7	9
10	R:R:L271	6.04	4	4	8
11	R:R:F272	8.028	5	0	8
12	R:R:W285	8.568	5	2	7
13	R:R:Q288	7.72	4	6	9
14	R:R:F289	7.74	4	6	8
15	R:R:R300	8.186	5	5	6
16	R:R:D302	7.092	5	5	7
17	R:R:T304	6.525	4	5	7
18	R:R:E309	4.69	4	0	7
19	R:R:F322	7.41833	6	9	9
20	R:R:Y326	8.375	4	9	9
21	R:R:Y327	4.94	4	0	8
22	R:R:W335	10.55	5	8	9
23	R:R:L339	4.6225	4	0	8
24	R:R:T340	5.4775	4	0	7
25	R:R:Y341	8.2375	4	7	7
26	R:R:W343	5.29167	6	0	9
27	R:R:F347	5.744	5	0	9
28	R:R:P356	4.5975	4	0	7
29	R:R:L357	5.5225	4	7	8
30	R:R:F364	6.56	4	7	9
31	R:R:I379	8.6175	4	9	7
32	R:R:D388	8.665	4	1	8
33	R:R:V390	5.3175	4	1	5
34	R:R:Y398	6.552	5	1	5
35	R:R:Y401	7.7275	4	3	3
36	R:R:L416	4.6175	4	0	7
37	R:R:F422	7.4375	4	0	8
38	R:R:F459	5.84167	6	4	8
39	R:R:F464	4.2225	4	0	5
40	R:R:F471	4.4975	4	0	7
41	R:R:W484	9.66	4	0	9
42	R:R:N515	7.5575	4	12	4
43	R:R:V521	4.475	4	11	6
44	R:R:F530	6.17833	6	2	9
45	R:R:M536	4.192	5	4	8
46	R:R:W539	9.405	4	4	9
47	R:R:W549	5.935	4	10	9

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:P207	R:R:W210	10.318	5.4	No	No	0	4	4
2	R:R:N206	R:R:P207	11.3204	6.52	No	No	0	5	4
3	R:R:N206	R:R:S209	13.3093	8.94	No	Yes	0	5	7
4	R:R:R300	R:R:S209	14.0135	6.59	Yes	Yes	5	6	7
5	R:R:F307	R:R:R300	44.4459	14.97	No	Yes	0	3	6
6	R:R:F307	R:R:K399	46.0397	7.44	No	No	0	3	3
7	R:R:D386	R:R:K399	46.8272	8.3	No	No	0	9	3
8	R:R:D386	R:R:Y398	47.6093	4.6	No	Yes	0	9	5
9	R:R:D388	R:R:Y398	53.9038	16.09	Yes	Yes	1	8	5
10	R:R:D388	R:R:N223	31.9241	5.39	Yes	Yes	1	8	7
11	R:R:N223	R:R:P224	13.6829	4.89	Yes	No	0	7	8
12	R:R:D388	R:R:V390	21.3938	8.76	Yes	Yes	1	8	5
13	R:R:H231	R:R:V390	15.6127	4.15	No	Yes	1	7	5
14	R:R:H231	R:R:Q222	13.7152	7.42	No	Yes	1	7	5
15	R:R:L225	R:R:N223	12.8229	4.12	No	Yes	0	6	7
16	R:R:V492	R:R:Y211	11.3984	5.05	No	Yes	0	6	7
17	R:R:F488	R:R:V492	13.3093	7.87	No	No	0	6	6
18	R:R:K523	R:R:Y237	20.3806	22.69	No	No	0	7	6
19	R:R:F241	R:R:Y237	10.834	11.35	No	No	0	4	6
20	R:R:F241	R:R:F530	12.4735	9.65	No	Yes	0	4	9
21	R:R:F530	R:R:T245	35.8293	7.78	Yes	No	0	9	7
22	R:R:I534	R:R:T245	37.8934	7.6	No	No	0	7	7
23	R:R:C248	R:R:I534	39.2426	4.91	No	No	0	6	7
24	R:R:C248	R:R:S537	39.9092	6.89	No	No	0	6	9
25	R:R:S537	R:R:T249	40.5703	4.8	No	No	0	9	8
26	R:R:N275	R:R:T249	43.1612	4.39	No	No	0	9	8
27	R:R:N275	R:R:T252	43.7955	5.85	No	No	0	9	8
28	R:R:T252	R:R:V540	44.4083	7.93	No	No	0	8	8
29	R:R:F256	R:R:V540	50.805	3.93	Yes	No	0	9	8
30	R:R:F256	R:R:F272	52.4337	18.22	Yes	Yes	0	9	8
31	R:R:F272	R:R:Y273	57.5832	6.19	Yes	No	0	8	8
32	R:R:W335	R:R:Y273	55.8739	21.22	Yes	No	8	9	8
33	R:R:V338	R:R:W335	61.7196	3.68	No	Yes	0	7	9
34	R:R:I270	R:R:V338	56.0002	4.61	No	No	0	8	7
35	R:R:I270	R:R:L339	56.4679	5.71	No	Yes	0	8	8
36	R:R:G460	R:R:L339	63.6386	1.71	No	Yes	0	7	8
37	R:R:G460	R:R:L423	63.7084	1.71	No	No	0	7	7
38	R:R:F464	R:R:L423	81.0654	3.65	Yes	No	0	5	7
39	R:R:F464	R:R:L416	100	4.87	Yes	Yes	0	5	7
40	R:R:F471	R:R:L416	99.3792	4.87	Yes	Yes	0	7	7
41	R:R:F471	R:R:L409	98.7099	6.09	Yes	No	0	7	8
42	R:R:F478	R:R:L409	98.2369	3.65	No	No	0	6	8
43	R:R:F478	R:R:Y401	97.2263	4.13	No	Yes	0	6	3
44	R:R:E485	R:R:Y401	95.5492	7.86	No	Yes	0	5	3
45	R:R:E485	R:R:Q481	95.2509	6.37	No	No	0	5	6
46	R:R:Q481	R:R:W484	94.9472	5.48	No	Yes	0	6	9
47	R:R:N480	R:R:W484	92.324	9.04	No	Yes	0	6	9
48	R:R:N480	R:R:Y476	91.6145	9.3	No	No	0	6	7
49	R:R:V521	R:R:Y476	90.5394	3.79	Yes	No	11	6	7
50	R:R:C473	R:R:V521	90.1309	3.42	No	Yes	0	7	6
51	R:R:C473	R:R:N525	88.9618	7.87	No	No	0	7	8
52	R:R:H474	R:R:N525	87.3277	12.75	No	No	0	7	8
53	R:R:H474	R:R:R404	85.4248	6.77	No	No	0	7	9
54	R:R:R404	R:R:Y398	84.9921	4.12	No	Yes	0	9	5
55	R:R:L526	R:R:Y237	11.2183	3.52	No	No	0	7	6
56	R:R:F530	R:R:L526	11.5919	3.65	Yes	No	2	9	7
57	R:R:K523	R:R:M234	17.0371	4.32	No	No	0	7	7
58	R:R:I238	R:R:M234	13.6722	4.37	No	No	0	7	7
59	R:R:F289	R:R:I238	11.9816	3.77	Yes	No	0	8	7
60	R:R:F336	R:R:F464	19.5716	5.36	No	Yes	0	9	5
61	R:R:F336	R:R:T340	19.5125	3.89	No	Yes	0	9	7
62	R:R:F422	R:R:T340	38.1917	5.19	Yes	Yes	0	8	7
63	R:R:F422	R:R:Y341	31.6338	15.47	Yes	Yes	0	8	7
64	R:R:L357	R:R:Y341	14.5215	5.86	Yes	Yes	7	8	7
65	R:R:L357	R:R:Y266	11.0221	4.69	Yes	Yes	7	8	9
66	R:R:P267	R:R:Y266	22.1894	4.17	No	Yes	0	9	9
67	R:R:L423	R:R:T340	20.824	7.37	No	Yes	0	7	7
68	R:R:F364	R:R:Y341	16.1851	4.13	Yes	Yes	7	9	7
69	R:R:F364	R:R:Y266	15.4487	8.25	Yes	Yes	7	9	9
70	R:R:L271	R:R:L339	17.701	8.3	Yes	Yes	0	8	8
71	R:R:E314	R:R:R300	27.5405	8.14	No	Yes	0	8	6
72	R:R:E309	R:R:E314	25.7129	5.07	Yes	No	0	7	8
73	R:R:C318	R:R:E309	20.1011	4.56	No	Yes	0	9	7
74	R:R:C318	R:R:C394	19.1469	7.28	No	No	0	9	9
75	R:R:F322	R:R:V385	16.2523	15.73	Yes	No	0	9	8
76	R:R:C394	R:R:V385	17.2226	3.42	No	No	0	9	8
77	R:R:F347	R:R:W343	12.1133	6.01	Yes	Yes	0	9	9
78	R:R:L456	R:R:W343	17.0076	7.97	No	Yes	0	8	9
79	R:R:L339	R:R:L456	17.7816	2.77	Yes	No	0	8	8
80	R:R:P267	R:R:Q355	19.9774	3.16	No	No	0	9	7
81	R:R:P356	R:R:Q355	13.4625	7.9	Yes	No	0	7	7
82	R:R:F364	R:R:V338	10.8152	6.55	Yes	No	0	9	7

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

there is no ligand in network 8CXO

PDB Summary
PDB	8CXO
Class	F
SubFamily	Protein
Type	Frizzled
SubType	SMO
Species	Mus Musculus
Ligand	-
Other Ligand(s)	-
Protein Partners	-
PDB Resolution	3.7
Date	2022-08-03
D.O.I.	10.1038/s41467-022-32125-2

Net Summary
I_min	3.42
Number of Linked Nodes	322
Number of Links	351
Number of Hubs	47
Number of Links mediated by Hubs	170
Number of Communities	12
Number of Nodes involved in Communities	58
Number of Links involved in Communities	74

Path Summary
Number Of Nodes in MetaPath	83
Number Of Links MetaPath	82
Number of Shortest Paths	65145
Length Of Smallest Path	3
Average Path Length	23.7469
Length of Longest Path	57
Minimum Path Strength	1.195
Average Path Strength	6.63202
Maximum Path Strength	18.145
Minimum Path Correlation	0.7
Average Path Correlation	0.946746
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	2.22222
Average % Of Corr. Nodes	45.5621
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	38.1201
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function	• UDP-glycosyltransferase activity • alpha-1,4-glucan glucosyltransferase (NDP-glucose donor) activity • glycosyltransferase activity • alpha-1,4-glucan glucosyltransferase (UDP-glucose donor) activity • transferase activity • glucosyltransferase activity • hexosyltransferase activity • catalytic activity • UDP-glucosyltransferase activity • patched binding • protein binding • binding • signaling receptor binding • protein serine/threonine kinase activity • enzyme regulator activity • catalytic activity, acting on a protein • kinase activity • cyclic nucleotide-dependent protein kinase activity • protein kinase activity • cAMP-dependent protein kinase activity • enzyme inhibitor activity • protein kinase regulator activity • phosphotransferase activity, alcohol group as acceptor • transferase activity, transferring phosphorus-containing groups • cAMP-dependent protein kinase regulator activity • protein kinase inhibitor activity • molecular function inhibitor activity • molecular function regulator activity • cAMP-dependent protein kinase inhibitor activity • protein serine/threonine kinase inhibitor activity • kinase inhibitor activity • kinase regulator activity • sterol binding • oxysterol binding • steroid binding • lipid binding • molecular transducer activity • G protein-coupled receptor activity • transmembrane signaling receptor activity • signaling receptor activity • molecular sequestering activity • protein sequestering activity • protein kinase A catalytic subunit binding • protein kinase A binding • kinase binding • enzyme binding • protein kinase binding • cellular response to stimulus • response to sterol • response to stimulus • response to lipid • response to alcohol • response to oxygen-containing compound • response to cholesterol • cellular response to oxygen-containing compound • cellular response to chemical stimulus • cellular response to alcohol • response to chemical • cellular response to lipid • cellular process • cellular response to sterol
Gene Ontology	Biological Process	• cellular response to stimulus • response to sterol • response to stimulus • response to lipid • response to alcohol • response to oxygen-containing compound • response to cholesterol • cellular response to oxygen-containing compound • cellular response to chemical stimulus • cellular response to alcohol • response to chemical • cellular response to lipid • cellular process • cellular response to sterol • cellular response to cholesterol • developmental process • multicellular organism development • multicellular organismal process • anatomical structure development • pattern specification process • regulation of protein stability • biological regulation • regulation of biological quality • protein stabilization • dorsal/ventral pattern formation • regionalization • apoptotic process • cell death • programmed cell death • regulation of cellular process • regulation of protein modification process • regulation of protein phosphorylation • negative regulation of biological process • negative regulation of phosphate metabolic process • regulation of primary metabolic process • regulation of phosphate metabolic process • phosphate-containing compound metabolic process • negative regulation of protein modification process • negative regulation of cellular process • protein metabolic process • protein modification process • phosphorus metabolic process • negative regulation of protein metabolic process • negative regulation of macromolecule metabolic process • regulation of biological process • protein phosphorylation • phosphorylation • regulation of protein metabolic process • negative regulation of metabolic process • primary metabolic process • regulation of macromolecule metabolic process • negative regulation of protein phosphorylation • macromolecule modification • negative regulation of phosphorus metabolic process • metabolic process • regulation of phosphorylation • regulation of phosphorus metabolic process • macromolecule metabolic process • negative regulation of phosphorylation • regulation of metabolic process • epithelium development • epidermis development • molting cycle process • hair cycle • epidermis morphogenesis • animal organ development • morphogenesis of an epithelium • tissue development • tissue morphogenesis • anatomical structure morphogenesis • skin development • skin epidermis development • hair follicle development • molting cycle • hair cycle process • hair follicle morphogenesis • cellular developmental process • astrocyte differentiation • cell development • astrocyte activation • glial cell development • neurogenesis • astrocyte development • gliogenesis • cell differentiation • response to stress • system development • defense response • cell activation • nervous system development • central nervous system development • glial cell differentiation • glial cell activation • inflammatory response • neuroinflammatory response • head development • brain morphogenesis • forebrain development • brain development • forebrain morphogenesis • animal organ morphogenesis • ossification • endocrine system development • type B pancreatic cell development • epithelial cell differentiation • epithelial cell development • pancreas development • endocrine pancreas development • enteroendocrine cell differentiation • type B pancreatic cell differentiation • RNA metabolic process • negative regulation of RNA biosynthetic process • RNA biosynthetic process • nucleobase-containing compound metabolic process • DNA-templated transcription • nucleic acid biosynthetic process • regulation of RNA metabolic process • transcription by RNA polymerase II • negative regulation of nucleobase-containing compound metabolic process • regulation of nucleobase-containing compound metabolic process • regulation of RNA biosynthetic process • regulation of biosynthetic process • regulation of transcription by RNA polymerase II • negative regulation of DNA-templated transcription • negative regulation of transcription by RNA polymerase II • nucleobase-containing compound biosynthetic process • gene expression • macromolecule biosynthetic process • nucleic acid metabolic process • regulation of gene expression • biosynthetic process • negative regulation of biosynthetic process • negative regulation of macromolecule biosynthetic process • regulation of macromolecule biosynthetic process • regulation of DNA-templated transcription • negative regulation of RNA metabolic process • multicellular organism growth • developmental growth • growth • regulation of somatic stem cell population maintenance • regulation of developmental process • regulation of stem cell population maintenance • stem cell population maintenance • somatic stem cell population maintenance • regulation of multicellular organismal process • maintenance of cell number • heart development • cardiac atrium morphogenesis • cardiac chamber morphogenesis • heart morphogenesis • cardiac atrium development • circulatory system development • cardiac septum development • cardiac septum morphogenesis • cardiac chamber development • atrial septum morphogenesis • atrial septum development • mesonephric epithelium development • kidney epithelium development • branching morphogenesis of an epithelial tube • nephron tubule morphogenesis • regulation of kidney development • regulation of branching involved in ureteric bud morphogenesis • positive regulation of developmental process • tube morphogenesis • nephron development • regulation of morphogenesis of a branching structure • regulation of animal organ morphogenesis • positive regulation of multicellular organismal process • mesonephric tubule development • renal tubule morphogenesis • nephron morphogenesis • nephron epithelium morphogenesis • positive regulation of biological process • nephron tubule development • renal system development • ureteric bud morphogenesis • positive regulation of morphogenesis of an epithelium • branching involved in ureteric bud morphogenesis • renal tubule development • regulation of morphogenesis of an epithelium • epithelial tube morphogenesis • regulation of anatomical structure morphogenesis • nephron epithelium development • ureteric bud development • tube development • mesonephros development • kidney morphogenesis • morphogenesis of a branching structure • positive regulation of branching involved in ureteric bud morphogenesis • mesonephric tubule morphogenesis • kidney development • morphogenesis of a branching epithelium • negative regulation of programmed cell death • regulation of apoptotic process • regulation of programmed cell death • negative regulation of apoptotic process • generation of neurons • central nervous system neuron differentiation • neuron differentiation • positive regulation of cell communication • positive regulation of signal transduction • signaling • regulation of signal transduction • cell communication • positive regulation of response to stimulus • positive regulation of smoothened signaling pathway • signal transduction • positive regulation of cellular process • regulation of smoothened signaling pathway • regulation of signaling • cell surface receptor signaling pathway • smoothened signaling pathway • regulation of response to stimulus • regulation of cell communication • positive regulation of signaling • positive regulation of mesenchymal cell proliferation • cell population proliferation • positive regulation of cell population proliferation • regulation of mesenchymal cell proliferation • regulation of cell population proliferation • mesenchymal cell proliferation • diencephalon development • thalamus development • left/right axis specification • left/right pattern formation • axis specification • regulation of heart morphogenesis • epithelial cell proliferation • blood vessel morphogenesis • vasculogenesis • vasculature development • blood vessel development • mesenchymal to epithelial transition involved in renal vesicle formation • renal vesicle morphogenesis • metanephric renal vesicle morphogenesis • renal vesicle development • metanephros development • metanephric renal vesicle formation • metanephros morphogenesis • metanephric nephron development • mesenchymal to epithelial transition involved in metanephric renal vesicle formation • mesenchymal to epithelial transition involved in metanephros morphogenesis • epithelial cell differentiation involved in kidney development • mesenchymal to epithelial transition • metanephric nephron morphogenesis • cell differentiation involved in metanephros development • cell differentiation involved in kidney development • anatomical structure formation involved in morphogenesis • renal vesicle formation • positive regulation of locomotion • regulation of cell motility • positive regulation of cell migration • regulation of locomotion • positive regulation of cell motility • regulation of cell migration • cell migration • cell motility • locomotion • regulation of growth • regulation of developmental growth • positive regulation of organ growth • organ growth • positive regulation of growth • regulation of organ growth • positive regulation of developmental growth • response to inositol • negative regulation of gene expression • lateral mesoderm development • mesenchyme development • determination of left/right asymmetry in lateral mesoderm • determination of bilateral symmetry • determination of left/right symmetry • mesoderm development • specification of symmetry • dopaminergic neuron differentiation • somite development • embryo development • cell fate specification • cell fate commitment • neuroblast proliferation • neural precursor cell proliferation • digestive system development • midgut development • digestive tract development • regulation of localization • localization • multicellular organismal-level homeostasis • homeostatic process • homeostasis of number of cells within a tissue • anatomical structure homeostasis • tissue homeostasis • homeostasis of number of cells • mammary gland epithelial cell differentiation • mammary gland development • gland development • mammary gland epithelium development • cell-cell signaling • epithelial-mesenchymal cell signaling • muscle cell migration • myoblast migration • positive regulation of macromolecule biosynthetic process • positive regulation of metabolic process • positive regulation of gene expression • positive regulation of biosynthetic process • positive regulation of macromolecule metabolic process • pancreas morphogenesis • cerebellum morphogenesis • cerebellar cortex morphogenesis • hindbrain morphogenesis • cerebellar cortex development • cerebellum development • metencephalon development • hindbrain development • protein localization • establishment of protein localization • cellular localization • nitrogen compound transport • nucleocytoplasmic transport • transport • nuclear transport • intracellular transport • protein localization to nucleus • establishment of localization • import into nucleus • establishment of protein localization to organelle • protein transport • cellular macromolecule localization • macromolecule localization • protein localization to organelle • establishment of localization in cell • protein import into nucleus • intracellular protein transport • regulation of protein localization • positive regulation of nucleocytoplasmic transport • positive regulation of establishment of protein localization • regulation of protein localization to nucleus • positive regulation of protein transport • regulation of protein import into nucleus • positive regulation of intracellular transport • regulation of intracellular transport • regulation of transport • positive regulation of protein localization to nucleus • regulation of establishment of protein localization • positive regulation of protein import into nucleus • regulation of nucleocytoplasmic transport • regulation of protein transport • positive regulation of transport • regulation of cellular localization • positive regulation of protein localization • regulation of intracellular protein transport • positive regulation of intracellular protein transport • embryo development ending in birth or egg hatching • chordate embryonic development • in utero embryonic development • embryonic organ development • pallium development • cerebral cortex development • telencephalon development • neural tube development • dorsal/ventral neural tube patterning • neural tube patterning • positive regulation of DNA-templated transcription • positive regulation of nucleobase-containing compound metabolic process • positive regulation of transcription by RNA polymerase II • positive regulation of RNA metabolic process • positive regulation of RNA biosynthetic process • embryonic heart tube development • embryonic heart tube morphogenesis • heart looping • embryonic organ morphogenesis • embryonic morphogenesis • determination of heart left/right asymmetry • osteoblast differentiation • myotube cell development • skeletal muscle fiber development • skeletal muscle tissue development • muscle cell differentiation • myotube differentiation • striated muscle tissue development • muscle structure development • skeletal muscle organ development • striated muscle cell development • muscle cell development • muscle tissue development • muscle organ development • striated muscle cell differentiation • odontogenesis of dentin-containing tooth • odontogenesis • ventral midline determination • ventral midline development • regulation of cell differentiation • regulation of epithelial cell differentiation • negative regulation of cell differentiation • regulation of multicellular organismal development • negative regulation of epithelial cell differentiation • negative regulation of developmental process • spinal cord dorsal/ventral patterning • spinal cord development • spinal cord patterning • positive regulation of epithelial cell proliferation • regulation of epithelial cell proliferation • stem cell development • neural crest cell differentiation • neural crest cell development • mesenchymal cell migration • stem cell differentiation • ameboidal-type cell migration • mesenchymal cell differentiation • neural crest cell migration • regulation of multicellular organism growth • positive regulation of multicellular organism growth • dentate gyrus development • hippocampus development • limbic system development • smooth muscle tissue development • regulation of molecular function • regulation of DNA binding • regulation of binding • negative regulation of binding • negative regulation of molecular function • negative regulation of DNA binding • regulation of hair cycle • regulation of hair follicle development • negative regulation of hair follicle development • negative regulation of multicellular organismal process • detection of stimulus • contact inhibition • detection of cell density • detection of biotic stimulus • response to biotic stimulus • positive regulation of nervous system development • regulation of neuroblast proliferation • regulation of neurogenesis • regulation of cell development • regulation of nervous system development • positive regulation of cell differentiation • positive regulation of neurogenesis • regulation of neural precursor cell proliferation • positive regulation of cell development • positive regulation of neural precursor cell proliferation • positive regulation of neuroblast proliferation • anterior/posterior pattern specification • intracellular organelle • microtubule organizing center • cellular anatomical structure • intracellular anatomical structure • cytoskeleton • organelle • membraneless organelle • centriole • intracellular membraneless organelle • microtubule cytoskeleton • membrane microdomain • cell periphery • membrane raft • plasma membrane raft
Gene Ontology	Cellular Component	• intracellular organelle • microtubule organizing center • cellular anatomical structure • intracellular anatomical structure • cytoskeleton • organelle • membraneless organelle • centriole • intracellular membraneless organelle • microtubule cytoskeleton • membrane microdomain • cell periphery • membrane raft • plasma membrane raft • membrane • plasma membrane • plasma membrane region • caveola • membrane-bounded organelle • cilium • ciliary membrane • plasma membrane bounded cell projection • cell projection • bounding membrane of organelle • organelle membrane • cell projection membrane • endosome • intracellular vesicle • intracellular membrane-bounded organelle • endomembrane system • cytoplasmic vesicle • late endosome • cytoplasm • vesicle • cytoplasmic vesicle membrane • vesicle membrane • endocytic vesicle membrane • endocytic vesicle • Golgi apparatus • endoplasmic reticulum-Golgi intermediate compartment • non-motile cilium • 9+0 non-motile cilium • endoplasmic reticulum
SCOP2	Domain Identifier	• Type B glycosyltransferase-like
SCOP2	Family Identifier	• Type B glycosyltransferase-like
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	Q99835
Sequence	>8CXO_Chain_R G Q C E A P L V R T D N P K S W Y E D V E G C G I Q C Q N P L F T E A E H Q D M H S Y I A A F G A V T G L C T L F T L A T F V A D W R N S N R Y P A V I L F Y V N A C F F V G S I G W L A Q F M D G A R R E I V C R A D G T M R F G E P T S S E T L S C V I I F V I V Y Y A L M A G V V W F V V L T Y A W H T S F K A L G T T Y Q P L S G K T S Y F H L L T W S L P F V L T V A I L A V A Q V D G D S V S G I C F V G Y K N Y R Y R A G F V L A P I G L V L I V G G Y F L I R G V M T L F S I K S N H P G L L N E T M L R L G I F G F L A F G F V L I T F S C H F Y D F F N Q A E W E R S F R D Y V L C Q A N V T D C E I K N R P S L L V E K I N L F A M F G T G I A M S T W V W T K A T L L I W R R T W C R L Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	8CXO	F	Protein	Frizzled	SMO	Mus musculus	-	-	-	3.7	2022-08-03	10.1038/s41467-022-32125-2
	7ZI0	F	Protein	Frizzled	SMO	Homo sapiens	SAG	Cholesterol	-	3	2022-06-15	10.1126/sciadv.abm5563
	6XBM	F	Protein	Frizzled	SMO	Homo sapiens	-	25(S)-Epoxycholesterol	Gi1/β1/γ2	3.14	2020-09-30	10.1038/s41589-020-0646-2
	6XBM (No Gprot)	F	Protein	Frizzled	SMO	Homo sapiens	-	25(S)-Epoxycholesterol		3.14	2020-09-30	10.1038/s41589-020-0646-2
	6XBL	F	Protein	Frizzled	SMO	Homo sapiens	SAG	Cholesterol	Gi1/β1/γ2	3.96	2020-09-30	10.1038/s41589-020-0646-2
	6XBL (No Gprot)	F	Protein	Frizzled	SMO	Homo sapiens	SAG	Cholesterol		3.96	2020-09-30	10.1038/s41589-020-0646-2
	6XBK	F	Protein	Frizzled	SMO	Homo sapiens	-	Cholesterol	Gi1/β1/γ2	3.24	2020-09-30	10.1038/s41589-020-0646-2
	6XBK (No Gprot)	F	Protein	Frizzled	SMO	Homo sapiens	-	Cholesterol		3.24	2020-09-30	10.1038/s41589-020-0646-2
	6XBJ	F	Protein	Frizzled	SMO	Homo sapiens	-	Cholesterol	Gi1/β1/γ2	3.88	2020-09-30	10.1038/s41589-020-0646-2
	6XBJ (No Gprot)	F	Protein	Frizzled	SMO	Homo sapiens	-	Cholesterol		3.88	2020-09-30	10.1038/s41589-020-0646-2
	6O3C	F	Protein	Frizzled	SMO	Mus musculus	SAG21k	Cholesterol	-	2.8	2019-07-03	10.1038/s41586-019-1355-4
	6OT0	F	Protein	Frizzled	SMO	Homo sapiens	-	25(S)-Epoxycholesterol	Gi1/β1/γ2	3.84	2019-06-12	10.1038/s41586-019-1286-0
	6OT0 (No Gprot)	F	Protein	Frizzled	SMO	Homo sapiens	-	25(S)-Epoxycholesterol		3.84	2019-06-12	10.1038/s41586-019-1286-0
	6D35	F	Protein	Frizzled	SMO	Xenopus laevis	-	Cholesterol	-	3.9	2018-05-23	10.1016/j.cell.2018.04.029
	6D32	F	Protein	Frizzled	SMO	Xenopus laevis	Cyclopamine	Cyclopamine	-	3.75	2018-05-23	10.1016/j.cell.2018.04.029
	5V57	F	Protein	Frizzled	SMO	Homo sapiens	TC114	-	-	3	2017-05-24	10.1038/ncomms15383
	5V56	F	Protein	Frizzled	SMO	Homo sapiens	TC114	-	-	2.9	2017-05-24	10.1038/ncomms15383
	5L7I	F	Protein	Frizzled	SMO	Homo sapiens	Vismodegib	-	-	3.3	2016-07-20	10.1038/nature18934
	5L7D	F	Protein	Frizzled	SMO	Homo sapiens	-	Cholesterol	-	3.2	2016-07-20	10.1038/nature18934
	4QIN	F	Protein	Frizzled	SMO	Homo sapiens	SAG1.5	-	-	2.6	2014-07-23	10.1038/ncomms5355
	4QIM	F	Protein	Frizzled	SMO	Homo sapiens	ANTA XV	-	-	2.61	2014-07-23	10.1038/ncomms5355
	4O9R	F	Protein	Frizzled	SMO	Homo sapiens	Cyclopamine	-	-	3.2	2014-03-05	10.1038/ncomms4309
	4N4W	F	Protein	Frizzled	SMO	Homo sapiens	-	SANT-1	-	2.8	2014-01-22	10.1038/ncomms5355
	4JKV	F	Protein	Frizzled	SMO	Homo sapiens	Taladegib	-	-	2.45	2013-04-24	10.1038/nature12167
	4JKV (Multimeric)	F	Protein	Frizzled	SMO	Homo sapiens	Taladegib	-		2.45	2013-04-24	10.1038/nature12167

You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download 8CXO.zip

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