psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:C193	R:R:L197	3.17	No	No	1	9	9
2	R:R:C193	R:R:C213	7.28	No	No	1	9	9
3	R:R:P196	R:R:V195	3.53	Yes	No	0	7	4
4	R:R:L197	R:R:P196	4.93	No	Yes	1	9	7
5	R:R:P196	R:R:P220	3.9	Yes	Yes	1	7	8
6	R:R:F484	R:R:P196	4.33	Yes	Yes	1	6	7
7	R:R:C213	R:R:L197	6.35	No	No	1	9	9
8	R:R:S205	R:R:T200	4.8	No	No	2	7	6
9	R:R:D298	R:R:T200	11.56	Yes	No	2	7	6
10	R:R:T200	R:R:T300	4.71	No	Yes	2	6	7
11	R:R:N202	R:R:P203	6.52	No	No	0	5	4
12	R:R:N202	R:R:S205	8.94	No	No	0	5	7
13	R:R:S205	R:R:T300	3.2	No	Yes	2	7	7
14	R:R:E211	R:R:W206	17.45	No	No	0	5	4
15	R:R:Y207	W:W:?2	21.19	No	Yes	0	7	0
16	R:R:I215	R:R:M301	5.83	No	No	1	5	4
17	R:R:I215	W:W:?2	5.61	No	Yes	1	5	0
18	R:R:P220	R:R:Q216	6.32	Yes	No	0	8	7
19	R:R:C217	R:R:Q218	4.58	No	Yes	0	9	5
20	R:R:C217	R:R:C295	7.28	No	No	0	9	9
21	R:R:E224	R:R:Q218	6.37	No	Yes	4	4	5
22	R:R:H227	R:R:Q218	6.18	Yes	Yes	4	7	5
23	R:R:Q218	R:R:S385	4.33	Yes	No	4	5	7
24	R:R:N219	R:R:P220	4.89	Yes	Yes	1	7	8
25	R:R:L221	R:R:N219	8.24	No	Yes	0	6	7
26	R:R:F222	R:R:N219	4.83	Yes	Yes	1	6	7
27	R:R:D384	R:R:N219	4.04	Yes	Yes	1	8	7
28	R:R:N219	W:W:?1	3.24	Yes	Yes	1	7	0
29	R:R:N219	W:W:?2	4.32	Yes	Yes	1	7	0
30	R:R:F484	R:R:P220	4.33	Yes	Yes	1	6	8
31	R:R:L221	R:R:P513	8.21	No	No	0	6	8
32	R:R:E226	R:R:F222	7	No	Yes	0	8	6
33	R:R:F222	R:R:V386	9.18	Yes	No	0	6	5
34	R:R:F222	R:R:P513	7.22	Yes	No	0	6	8
35	R:R:E518	R:R:F222	4.66	No	Yes	1	7	6
36	R:R:F222	W:W:?1	5.74	Yes	Yes	1	6	0
37	R:R:E224	R:R:H227	3.69	No	Yes	4	4	7
38	R:R:E226	R:R:L515	14.58	No	No	0	8	5
39	R:R:H227	R:R:H231	5.97	Yes	No	0	7	7
40	R:R:H227	R:R:S385	6.97	Yes	No	4	7	7
41	R:R:H227	R:R:V386	9.69	Yes	No	0	7	5
42	R:R:D229	R:R:K519	6.91	No	No	0	6	7
43	R:R:I234	R:R:M230	5.83	No	No	0	7	7
44	R:R:L515	R:R:M230	4.24	No	No	0	5	7
45	R:R:K519	R:R:M230	4.32	No	No	0	7	7
46	R:R:H231	R:R:R290	18.05	No	No	0	7	9
47	R:R:F237	R:R:Y233	13.41	No	No	0	4	6
48	R:R:K519	R:R:Y233	27.47	No	No	0	7	6
49	R:R:L522	R:R:Y233	3.52	No	No	0	7	6
50	R:R:I234	R:R:W281	3.52	No	Yes	0	7	7
51	R:R:A235	R:R:F285	5.55	No	Yes	0	5	8
52	R:R:F237	R:R:F523	4.29	No	No	0	4	6
53	R:R:F237	R:R:F526	6.43	No	Yes	0	4	9
54	R:R:F526	R:R:G238	4.52	Yes	No	0	9	7
55	R:R:S278	R:R:T241	3.2	No	No	0	8	7
56	R:R:F526	R:R:T241	7.78	Yes	No	0	9	7
57	R:R:G242	R:R:S278	3.71	No	No	0	4	8
58	R:R:C244	R:R:S533	5.16	No	No	0	6	9
59	R:R:F275	R:R:T245	5.19	Yes	No	0	5	8
60	R:R:F275	R:R:L246	8.53	Yes	No	0	5	6
61	R:R:F247	R:R:T251	7.78	No	No	0	8	9
62	R:R:N271	R:R:T248	16.08	No	No	0	9	8
63	R:R:T248	R:R:V536	9.52	No	No	0	8	8
64	R:R:F268	R:R:L249	3.65	Yes	No	0	8	6
65	R:R:F275	R:R:L249	4.87	Yes	No	0	5	6
66	R:R:F252	R:R:F268	13.93	No	Yes	0	9	8
67	R:R:F252	R:R:V536	3.93	No	No	0	9	8
68	R:R:D255	R:R:N258	4.04	No	No	0	8	8
69	R:R:N260	R:R:W256	18.08	No	No	0	7	7
70	R:R:F268	R:R:W256	9.02	Yes	No	0	8	7
71	R:R:N258	R:R:S259	5.96	No	No	0	8	8
72	R:R:N260	R:R:V265	4.43	No	No	0	7	8
73	R:R:A264	R:R:R261	8.3	No	No	0	9	7
74	R:R:V265	R:R:Y262	3.79	No	Yes	0	8	9
75	R:R:T357	R:R:Y262	17.48	No	Yes	0	6	9
76	R:R:F360	R:R:Y262	6.19	Yes	Yes	0	9	9
77	R:R:H361	R:R:Y262	7.62	Yes	Yes	0	9	9
78	R:R:L353	R:R:P263	3.28	No	No	0	8	9
79	R:R:F268	R:R:V265	3.93	Yes	No	0	8	8
80	R:R:I266	R:R:W331	9.4	No	Yes	0	8	9
81	R:R:I266	R:R:L335	7.14	No	No	0	8	8
82	R:R:L267	R:R:W535	7.97	No	Yes	0	8	9
83	R:R:F268	R:R:Y269	6.19	Yes	No	0	8	8
84	R:R:W331	R:R:Y269	14.47	Yes	No	3	9	8
85	R:R:H361	R:R:Y269	9.8	Yes	No	3	9	8
86	R:R:M532	R:R:V270	6.09	Yes	No	0	8	8
87	R:R:C273	R:R:G328	3.92	No	No	0	9	8
88	R:R:F274	R:R:T528	3.89	Yes	No	0	9	7
89	R:R:F274	R:R:G529	6.02	Yes	No	0	9	9
90	R:R:F274	R:R:M532	3.73	Yes	Yes	0	9	8
91	R:R:F275	R:R:I279	7.54	Yes	No	0	5	5
92	R:R:A324	R:R:V276	3.39	No	No	0	7	5
93	R:R:V321	R:R:W281	6.13	No	Yes	0	8	7
94	R:R:S387	R:R:W281	3.71	Yes	Yes	1	8	7
95	R:R:I389	R:R:W281	11.74	No	Yes	1	9	7
96	R:R:L522	R:R:W281	3.42	No	Yes	0	7	7
97	R:R:M525	R:R:W281	5.82	No	Yes	1	5	7
98	R:R:F526	R:R:W281	6.01	Yes	Yes	0	9	7
99	R:R:F285	R:R:Q284	9.37	Yes	No	5	8	9
100	R:R:Q284	R:R:R290	3.5	No	No	5	9	9
101	R:R:G388	R:R:Q284	4.93	No	No	0	9	9
102	R:R:F285	R:R:R290	6.41	Yes	No	5	8	9
103	R:R:I293	R:R:I317	8.83	No	No	0	8	7
104	R:R:C295	R:R:V294	3.42	No	No	0	9	8
105	R:R:D298	R:R:R296	5.96	Yes	Yes	2	7	6
106	R:R:R296	R:R:T300	6.47	Yes	Yes	2	6	7
107	R:R:R296	R:R:R302	4.26	Yes	Yes	0	6	6
108	R:R:E310	R:R:R296	9.3	Yes	Yes	0	8	6
109	R:R:D298	R:R:G299	3.35	Yes	No	0	7	4
110	R:R:D298	R:R:T300	13.01	Yes	Yes	2	7	7
111	R:R:L303	R:R:M301	5.65	No	No	0	3	4
112	R:R:M301	W:W:?2	4.44	No	Yes	1	4	0
113	R:R:E305	R:R:R302	17.45	No	Yes	0	7	6
114	R:R:R302	R:R:T311	9.06	Yes	No	0	6	7
115	R:R:C314	R:R:R302	6.96	No	Yes	0	9	6
116	R:R:K395	R:R:L303	11.28	No	No	0	3	3
117	R:R:E305	R:R:T307	7.06	No	No	0	7	6
118	R:R:E305	R:R:E310	3.81	No	Yes	0	7	8
119	R:R:L376	R:R:P306	3.28	No	Yes	0	8	5
120	R:R:A379	R:R:P306	3.74	No	Yes	0	6	5
121	R:R:P306	R:R:V381	3.53	Yes	No	0	5	8
122	R:R:E310	R:R:N309	7.89	Yes	No	0	8	6
123	R:R:E310	R:R:T311	8.47	Yes	No	0	8	7
124	R:R:S313	R:R:T311	3.2	No	No	0	7	7
125	R:R:C314	R:R:C390	7.28	No	No	0	9	9
126	R:R:L376	R:R:V315	5.96	No	No	0	8	7
127	R:R:F318	R:R:Y322	6.19	No	Yes	1	9	9
128	R:R:F318	R:R:I375	5.02	No	Yes	1	9	7
129	R:R:F318	R:R:V381	13.11	No	No	0	9	8
130	R:R:T372	R:R:V319	4.76	No	No	0	9	7
131	R:R:M326	R:R:Y322	9.58	No	Yes	0	8	9
132	R:R:L371	R:R:Y322	7.03	No	Yes	1	8	9
133	R:R:I375	R:R:Y322	6.04	Yes	Yes	1	7	9
134	R:R:F391	R:R:Y322	3.09	No	Yes	1	8	9
135	R:R:F403	R:R:Y322	3.09	Yes	Yes	1	8	9
136	R:R:W365	R:R:Y323	8.68	Yes	Yes	0	9	8
137	R:R:P368	R:R:Y323	5.56	No	Yes	0	9	8
138	R:R:F369	R:R:Y323	4.13	No	Yes	0	7	8
139	R:R:L325	R:R:M525	4.24	No	No	1	5	5
140	R:R:L325	W:W:?1	4.35	No	Yes	1	5	0
141	R:R:M326	R:R:P368	3.35	No	No	0	8	9
142	R:R:M326	R:R:P407	6.71	No	No	0	8	9
143	R:R:V329	R:R:V411	4.81	No	No	0	6	5
144	R:R:T364	R:R:V330	4.76	No	No	0	9	6
145	R:R:V334	R:R:W331	4.9	No	Yes	0	7	9
146	R:R:H361	R:R:W331	10.58	Yes	Yes	3	9	9
147	R:R:T364	R:R:W331	25.47	No	Yes	3	9	9
148	R:R:W331	R:R:W365	12.18	Yes	Yes	3	9	9
149	R:R:F332	R:R:T336	5.19	Yes	No	0	9	7
150	R:R:F332	R:R:F455	6.43	Yes	No	7	9	8
151	R:R:F332	R:R:M532	8.71	Yes	Yes	7	9	8
152	R:R:V333	R:R:V411	3.21	No	No	0	9	5
153	R:R:V333	R:R:V414	3.21	No	No	0	9	5
154	R:R:F360	R:R:V334	9.18	Yes	No	0	9	7
155	R:R:L335	R:R:W339	19.36	No	Yes	0	8	9
156	R:R:G415	R:R:T336	3.64	No	No	0	8	7
157	R:R:T341	R:R:Y337	4.99	No	Yes	0	6	7
158	R:R:K356	R:R:Y337	4.78	No	Yes	6	8	7
159	R:R:F360	R:R:Y337	4.13	Yes	Yes	6	9	7
160	R:R:F418	R:R:Y337	12.38	No	Yes	0	8	7
161	R:R:F343	R:R:W339	6.01	Yes	Yes	8	9	9
162	R:R:L452	R:R:W339	4.56	Yes	Yes	8	8	9
163	R:R:W339	R:R:W535	9.37	Yes	Yes	0	9	9
164	R:R:H340	R:R:K344	9.17	No	No	0	7	6
165	R:R:H340	R:R:R421	6.77	No	No	0	7	7
166	R:R:G422	R:R:H340	3.18	No	No	0	8	7
167	R:R:P352	R:R:T341	3.5	Yes	No	0	7	6
168	R:R:L353	R:R:T341	4.42	No	No	0	8	6
169	R:R:F343	R:R:L426	17.05	Yes	No	0	9	9
170	R:R:F343	R:R:L452	3.65	Yes	Yes	8	9	8
171	R:R:A345	R:R:P352	3.74	No	Yes	0	7	7
172	R:R:I429	R:R:L346	4.28	No	No	0	7	6
173	R:R:P352	R:R:Y350	8.34	Yes	No	0	7	7
174	R:R:F360	R:R:K356	3.72	Yes	No	6	9	8
175	R:R:H361	R:R:W365	8.46	Yes	Yes	3	9	9
176	R:R:L363	R:R:L367	4.15	No	No	0	4	5
177	R:R:T364	R:R:W365	3.64	No	Yes	3	9	9
178	R:R:F369	R:R:V373	7.87	No	No	0	7	7
179	R:R:F403	R:R:L371	4.87	Yes	No	1	8	8
180	R:R:I375	R:R:V392	4.61	Yes	No	1	7	9
181	R:R:F403	R:R:I375	15.07	Yes	Yes	1	8	7
182	R:R:Q380	R:R:V378	7.16	No	No	1	7	5
183	R:R:V378	R:R:Y399	5.05	No	Yes	1	5	5
184	R:R:N396	R:R:Q380	11.88	No	No	1	7	7
185	R:R:Q380	R:R:Y399	23.67	No	Yes	1	7	5
186	R:R:C390	R:R:V381	3.42	No	No	0	9	8
187	R:R:D382	R:R:Y394	6.9	No	Yes	0	9	5
188	R:R:D382	R:R:K395	9.68	No	No	0	9	3
189	R:R:D384	R:R:V386	5.84	Yes	No	0	8	5
190	R:R:D384	R:R:S387	5.89	Yes	Yes	1	8	8
191	R:R:D384	R:R:Y394	9.2	Yes	Yes	1	8	5
192	R:R:D384	W:W:?1	11.73	Yes	Yes	1	8	0
193	R:R:I389	R:R:S387	4.64	No	Yes	1	9	8
194	R:R:S387	W:W:?1	3.54	Yes	Yes	1	8	0
195	R:R:F391	R:R:Y394	5.16	No	Yes	1	8	5
196	R:R:F391	W:W:?1	5.74	No	Yes	1	8	0
197	R:R:F403	R:R:V392	3.93	Yes	No	1	8	9
198	R:R:Y394	W:W:?1	11.05	Yes	Yes	1	5	0
199	R:R:N396	R:R:Y399	10.47	No	Yes	1	7	5
200	R:R:R398	R:R:Y397	7.2	No	Yes	0	1	3
201	R:R:R400	R:R:Y397	3.09	Yes	Yes	1	9	3
202	R:R:F474	R:R:Y397	12.38	Yes	Yes	1	6	3
203	R:R:Q477	R:R:Y397	4.51	No	Yes	0	6	3
204	R:R:F403	R:R:Y399	3.09	Yes	Yes	1	8	5
205	R:R:H470	R:R:R400	5.64	Yes	Yes	1	7	9
206	R:R:F474	R:R:R400	6.41	Yes	Yes	1	6	9
207	R:R:R400	W:W:?1	10.5	Yes	Yes	1	9	0
208	R:R:F467	R:R:L405	13.4	No	No	0	7	8
209	R:R:H470	R:R:L405	11.57	Yes	No	0	7	8
210	R:R:L412	R:R:V463	11.92	No	No	0	7	7
211	R:R:F418	R:R:V414	3.93	No	No	0	8	5
212	R:R:F418	R:R:Y417	6.19	No	No	0	8	5
213	R:R:R421	R:R:Y417	14.4	No	No	0	7	5
214	R:R:G456	R:R:L419	3.42	No	No	0	7	7
215	R:R:G422	R:R:T425	3.64	No	No	0	8	7
216	R:R:L452	R:R:V423	4.47	Yes	No	0	8	7
217	R:R:L426	R:R:M449	5.65	No	No	0	9	9
218	R:R:F427	R:R:M449	4.98	No	No	0	7	9
219	R:R:N432	R:R:S431	5.96	No	No	0	6	5
220	R:R:H433	R:R:P434	6.1	No	No	0	8	7
221	R:R:G435	R:R:H433	4.77	No	No	0	5	8
222	R:R:H433	R:R:L437	9	No	Yes	0	8	6
223	R:R:A441	R:R:L437	3.15	No	Yes	0	8	6
224	R:R:K440	R:R:K444	10.06	No	No	0	6	9
225	R:R:E447	R:R:R451	13.96	No	No	0	6	9
226	R:R:R451	R:R:W535	10	No	Yes	0	9	9
227	R:R:F455	R:R:M532	3.73	No	Yes	7	8	8
228	R:R:F455	R:R:W535	23.05	No	Yes	0	8	9
229	R:R:F462	R:R:L458	4.87	No	No	0	7	6
230	R:R:A531	R:R:L458	3.15	No	No	0	6	6
231	R:R:F462	R:R:G527	4.52	No	No	0	7	5
232	R:R:F462	R:R:T528	9.08	No	No	0	7	7
233	R:R:A524	R:R:I465	3.25	No	No	0	7	5
234	R:R:T466	W:W:?1	6.95	No	Yes	0	8	0
235	R:R:C469	R:R:V517	3.42	No	No	0	7	6
236	R:R:C469	R:R:I520	3.27	No	No	0	7	5
237	R:R:C469	R:R:N521	7.87	No	No	0	7	8
238	R:R:H470	R:R:N521	3.83	Yes	No	1	7	8
239	R:R:H470	W:W:?1	5.05	Yes	Yes	1	7	0
240	R:R:F471	R:R:F474	4.29	No	Yes	0	4	6
241	R:R:N476	R:R:Y472	6.98	No	No	0	6	7
242	R:R:S514	R:R:Y472	7.63	No	No	9	7	7
243	R:R:V517	R:R:Y472	8.83	No	No	9	6	7
244	R:R:D473	R:R:N476	5.39	No	No	0	8	6
245	R:R:D473	R:R:E518	3.9	No	No	1	8	7
246	R:R:D473	W:W:?1	3.2	No	Yes	1	8	0
247	R:R:N476	R:R:W480	9.04	No	No	0	6	9
248	R:R:S483	R:R:W480	6.18	No	No	0	7	9
249	R:R:P513	R:R:W480	18.92	No	No	0	8	9
250	R:R:E481	R:R:R482	12.79	No	No	0	5	3
251	R:R:F484	R:R:V488	7.87	Yes	No	0	6	6
252	R:R:F484	W:W:?2	4.79	Yes	Yes	1	6	0
253	R:R:R485	W:W:?2	12.41	No	Yes	0	5	0
254	R:R:Q491	R:R:Y487	5.64	No	No	0	4	4
255	R:R:L489	R:R:N493	6.87	No	No	0	4	5
256	R:R:C490	R:R:Q491	4.58	No	No	0	9	4
257	R:R:S514	R:R:V517	4.85	No	No	9	7	6
258	R:R:I520	R:R:L516	7.14	No	No	0	5	4
259	R:R:E518	W:W:?1	11.45	No	Yes	1	7	0
260	R:R:N521	W:W:?1	9.71	No	Yes	1	8	0
261	R:R:M525	W:W:?1	13.33	No	Yes	1	5	0
262	R:R:I530	R:R:S533	3.1	No	No	0	7	9
263	R:R:T534	R:R:W537	16.98	No	No	0	7	8
264	R:R:I320	R:R:V276	3.07	No	No	0	5	5
265	R:R:I408	R:R:V329	3.07	No	No	0	7	6
266	R:R:I408	R:R:V463	3.07	No	No	0	7	7
267	R:R:I530	R:R:T241	3.04	No	No	0	7	7
268	R:R:I429	R:R:T425	3.04	No	No	0	7	7
269	R:R:F247	R:R:W537	3.01	No	No	0	8	8
270	R:R:F274	R:R:G328	3.01	Yes	No	0	9	8
271	R:R:F467	R:R:G409	3.01	No	No	0	7	4
272	R:R:L312	R:R:S308	3	No	No	0	7	8
273	R:R:L367	R:R:S366	3	No	No	0	5	7
274	R:R:L376	R:R:V319	2.98	No	No	0	8	7
275	R:R:L405	R:R:V404	2.98	No	No	0	8	7
276	R:R:L410	R:R:V414	2.98	No	No	0	4	5
277	R:R:L419	R:R:T336	2.95	No	No	0	7	7
278	R:R:L426	R:R:T448	2.95	No	No	0	9	8
279	R:R:I317	R:R:I389	2.94	No	No	0	7	9
280	R:R:I445	R:R:L346	2.85	No	No	0	9	6
281	R:R:M449	R:R:N446	2.8	No	No	0	9	7
282	R:R:A401	R:R:F474	2.77	No	Yes	0	6	6
283	R:R:P203	R:R:W206	2.7	No	No	0	4	4
284	R:R:A327	R:R:Y323	2.67	No	Yes	0	9	8
285	R:R:R261	R:R:S259	2.64	No	No	0	7	8
286	R:R:M424	R:R:R421	2.48	No	No	0	5	7
287	R:R:F285	R:R:L282	2.44	Yes	No	0	8	7
288	R:R:D486	R:R:R485	2.38	No	No	0	4	5
289	R:R:Q192	R:R:R199	2.34	No	No	0	4	4
290	R:R:G415	R:R:G416	2.11	No	No	0	8	5
291	R:R:G304	R:R:P306	2.03	No	Yes	0	5	5
292	R:R:C390	R:R:G383	1.96	No	No	0	9	8
293	R:R:A324	R:R:G277	1.95	No	No	0	7	6
294	R:R:A283	R:R:G280	1.95	No	No	0	5	7
295	R:R:A401	R:R:G402	1.95	No	No	0	6	5
296	R:R:A406	R:R:G402	1.95	No	No	0	5	5
297	R:R:G355	R:R:S354	1.86	No	No	0	6	7
298	R:R:G299	R:R:V198	1.84	No	No	0	4	6
299	R:R:G280	R:R:V321	1.84	No	No	0	7	8
300	R:R:G393	R:R:V392	1.84	No	No	0	9	9
301	R:R:G214	R:R:T300	1.82	No	Yes	0	8	7
302	R:R:G280	R:R:I320	1.76	No	No	0	7	5
303	R:R:C213	R:R:V210	1.71	No	No	0	9	5
304	R:R:G435	R:R:L436	1.71	No	No	0	5	6
305	R:R:A441	R:R:S438	1.71	No	No	0	8	8
306	R:R:G453	R:R:L452	1.71	No	Yes	0	5	8
307	R:R:G461	R:R:L464	1.71	No	No	0	5	4
308	R:R:C490	R:R:V494	1.71	No	No	0	9	5
309	R:R:A225	R:R:T223	1.68	No	No	0	4	5
310	R:R:D287	R:R:G288	1.68	No	No	0	5	6
311	R:R:A345	R:R:T348	1.68	No	No	0	7	7
312	R:R:A524	R:R:T466	1.68	No	No	0	7	8
313	R:R:L367	R:R:P368	1.64	No	No	0	5	9
314	R:R:A338	R:R:I266	1.62	No	No	0	8	8
315	R:R:A289	R:R:M286	1.61	No	No	0	7	4
316	R:R:S358	R:R:T357	1.6	No	No	0	6	6
317	R:R:A272	R:R:L249	1.58	No	No	0	4	6
318	R:R:P352	R:R:Q351	1.58	Yes	No	0	7	7
319	R:R:A442	R:R:L437	1.58	No	Yes	0	8	6
320	R:R:E194	R:R:P196	1.57	No	Yes	0	6	7
321	R:R:I530	R:R:V240	1.54	No	No	0	7	4
322	R:R:K440	R:R:S438	1.53	No	No	0	6	8
323	R:R:A225	R:R:Q228	1.52	No	No	0	4	3
324	R:R:A297	R:R:E310	1.51	No	Yes	0	5	8
325	R:R:L312	R:R:V315	1.49	No	No	0	7	7
326	R:R:N432	R:R:S428	1.49	No	No	0	6	5
327	R:R:I316	R:R:I317	1.47	No	No	0	5	7
328	R:R:I420	R:R:M424	1.46	No	No	0	5	5
329	R:R:I429	R:R:L437	1.43	No	Yes	0	7	6
330	R:R:I454	R:R:L450	1.43	No	No	0	6	6
331	R:R:I496	R:R:N493	1.42	No	No	0	4	5
332	R:R:K204	R:R:N202	1.4	No	No	0	3	5
333	R:R:A459	R:R:F332	1.39	No	Yes	0	7	9
334	R:R:A478	R:R:R482	1.38	No	No	0	3	3
335	R:R:F343	R:R:S342	1.32	Yes	No	0	9	8
336	R:R:F247	R:R:V536	1.31	No	No	0	8	8
337	R:R:F460	R:R:L412	1.22	No	No	0	5	7
338	R:R:F474	R:R:F475	1.07	Yes	No	0	6	3
339	R:R:E481	W:W:?2	1.04	No	Yes	0	5	0

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	R:R:P196	3.652	5	1	7
2	R:R:Q218	5.365	4	4	5
3	R:R:N219	4.92667	6	1	7
4	R:R:P220	4.86	4	1	8
5	R:R:F222	6.43833	6	1	6
6	R:R:H227	6.5	5	4	7
7	R:R:Y262	8.77	4	0	9
8	R:R:F268	7.344	5	0	8
9	R:R:F274	4.1625	4	0	9
10	R:R:F275	6.5325	4	0	5
11	R:R:W281	5.76429	7	1	7
12	R:R:F285	5.9425	4	5	8
13	R:R:R296	6.4975	4	2	6
14	R:R:D298	8.47	4	2	7
15	R:R:T300	5.842	5	2	7
16	R:R:R302	9.4325	4	0	6
17	R:R:P306	3.145	4	0	5
18	R:R:E310	6.196	5	0	8
19	R:R:Y322	5.83667	6	1	9
20	R:R:Y323	5.26	4	0	8
21	R:R:W331	12.8333	6	3	9
22	R:R:F332	5.43	4	7	9
23	R:R:Y337	6.57	4	6	7
24	R:R:W339	9.825	4	8	9
25	R:R:F343	7.0075	4	8	9
26	R:R:P352	4.29	4	0	7
27	R:R:F360	5.805	4	6	9
28	R:R:H361	9.115	4	3	9
29	R:R:W365	8.24	4	3	9
30	R:R:I375	7.685	4	1	7
31	R:R:D384	7.34	5	1	8
32	R:R:S387	4.445	4	1	8
33	R:R:Y394	8.0775	4	1	5
34	R:R:Y397	6.795	4	1	3
35	R:R:Y399	10.57	4	1	5
36	R:R:R400	6.41	4	1	9
37	R:R:F403	6.01	5	1	8
38	R:R:L437	3.79	4	0	6
39	R:R:L452	3.5975	4	8	8
40	R:R:H470	6.5225	4	1	7
41	R:R:F474	5.384	5	1	6
42	R:R:F484	5.33	4	1	6
43	R:R:F526	6.185	4	0	9
44	R:R:M532	5.565	4	7	8
45	R:R:W535	12.5975	4	0	9
46	W:W:?1	7.54143	14	1	0
47	W:W:?2	7.68571	7	1	0

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:N219	R:R:P220	10.3634	4.89	Yes	Yes	1	7	8
2	R:R:N219	W:W:?1	18.2336	3.24	Yes	Yes	1	7	0
3	R:R:F391	W:W:?1	88.5322	5.74	No	Yes	1	8	0
4	R:R:F391	R:R:Y322	100	3.09	No	Yes	1	8	9
5	R:R:F318	R:R:Y322	37.2058	6.19	No	Yes	1	9	9
6	R:R:F318	R:R:V381	37.2255	13.11	No	No	0	9	8
7	R:R:C390	R:R:V381	28.9062	3.42	No	No	0	9	8
8	R:R:C314	R:R:C390	27.1835	7.28	No	No	0	9	9
9	R:R:C314	R:R:R302	26.3148	6.96	No	Yes	0	9	6
10	R:R:R296	R:R:R302	16.155	4.26	Yes	Yes	0	6	6
11	R:R:F222	R:R:V386	11.2395	9.18	Yes	No	0	6	5
12	R:R:H227	R:R:V386	29.4069	9.69	Yes	No	0	7	5
13	R:R:D384	R:R:V386	20.2582	5.84	Yes	No	0	8	5
14	R:R:H227	R:R:H231	14.8225	5.97	Yes	No	0	7	7
15	R:R:S387	R:R:W281	21.7993	3.71	Yes	Yes	1	8	7
16	R:R:S387	W:W:?1	22.911	3.54	Yes	Yes	1	8	0
17	R:R:M525	W:W:?1	20.0594	13.33	No	Yes	1	5	0
18	R:R:M525	R:R:W281	19.4066	5.82	No	Yes	1	5	7
19	R:R:H231	R:R:R290	12.7193	18.05	No	No	0	7	9
20	R:R:F526	R:R:W281	17.7575	6.01	Yes	Yes	0	9	7
21	R:R:F526	R:R:T241	11.4383	7.78	Yes	No	0	9	7
22	R:R:M326	R:R:Y322	99.735	9.58	No	Yes	0	8	9
23	R:R:M326	R:R:P368	99.4503	3.35	No	No	0	8	9
24	R:R:P368	R:R:Y323	98.8221	5.56	No	Yes	0	9	8
25	R:R:W365	R:R:Y323	98.1153	8.68	Yes	Yes	0	9	8
26	R:R:W331	R:R:W365	58.1094	12.18	Yes	Yes	3	9	9
27	R:R:W331	R:R:Y269	12.1942	14.47	Yes	No	3	9	8
28	R:R:F268	R:R:Y269	20.9944	6.19	Yes	No	0	8	8
29	R:R:H361	R:R:W365	38.6513	8.46	Yes	Yes	3	9	9
30	R:R:H361	R:R:Y269	10.2604	9.8	Yes	No	3	9	8
31	R:R:F252	R:R:F268	11.4825	13.93	No	Yes	0	9	8
32	R:R:F252	R:R:V536	10.0641	3.93	No	No	0	9	8
33	R:R:H361	R:R:Y262	28.6535	7.62	Yes	Yes	0	9	9
34	R:R:V334	R:R:W331	29.932	4.9	No	Yes	0	7	9
35	R:R:F360	R:R:V334	29.3087	9.18	Yes	No	0	9	7
36	R:R:F360	R:R:Y262	27.4289	6.19	Yes	Yes	0	9	9
37	R:R:F360	R:R:Y337	54.1019	4.13	Yes	Yes	6	9	7
38	R:R:T341	R:R:Y337	11.4923	4.99	No	Yes	0	6	7
39	R:R:I266	R:R:W331	28.3173	9.4	No	Yes	0	8	9
40	R:R:I266	R:R:L335	26.9724	7.14	No	No	0	8	8
41	R:R:L335	R:R:W339	26.2779	19.36	No	Yes	0	8	9
42	R:R:W339	R:R:W535	18.4544	9.37	Yes	Yes	0	9	9
43	R:R:F455	R:R:W535	15.4679	23.05	No	Yes	0	8	9
44	R:R:V321	R:R:W281	11.4727	6.13	No	Yes	0	8	7
45	R:R:F418	R:R:Y337	42.6734	12.38	No	Yes	0	8	7
46	R:R:F418	R:R:V414	12.9181	3.93	No	No	0	8	5
47	R:R:V333	R:R:V414	10.0812	3.21	No	No	0	9	5
48	R:R:F418	R:R:Y417	29.3725	6.19	No	No	0	8	5
49	R:R:R421	R:R:Y417	28.0154	14.4	No	No	0	7	5
50	R:R:H340	R:R:R421	23.9147	6.77	No	No	0	7	7
51	R:R:G422	R:R:H340	21.1563	3.18	No	No	0	8	7
52	R:R:G422	R:R:T425	19.7698	3.64	No	No	0	8	7
53	R:R:I429	R:R:T425	18.3784	3.04	No	No	0	7	7
54	R:R:I429	R:R:L437	14.3292	1.43	No	Yes	0	7	6
55	R:R:N219	W:W:?2	10.6481	4.32	Yes	Yes	1	7	0
56	R:R:F222	W:W:?1	15.9808	5.74	Yes	Yes	1	6	0
57	R:R:D384	W:W:?1	10.307	11.73	Yes	Yes	1	8	0
58	R:R:F391	R:R:Y394	11.3352	5.16	No	Yes	1	8	5

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:P196	R:R:P220	3.9	1	Yes	Yes	7	8	2	2
R:R:F484	R:R:P196	4.33	1	Yes	Yes	6	7	1	2
R:R:Y207	W:W:?2	21.19	0	No	Yes	7	0	1	0
R:R:I215	R:R:M301	5.83	1	No	No	5	4	1	1
R:R:I215	W:W:?2	5.61	1	No	Yes	5	0	1	0
R:R:N219	R:R:P220	4.89	1	Yes	Yes	7	8	1	2
R:R:L221	R:R:N219	8.24	0	No	Yes	6	7	2	1
R:R:F222	R:R:N219	4.83	1	Yes	Yes	6	7	2	1
R:R:D384	R:R:N219	4.04	1	Yes	Yes	8	7	2	1
R:R:N219	W:W:?1	3.24	1	Yes	Yes	7	0	1	2
R:R:N219	W:W:?2	4.32	1	Yes	Yes	7	0	1	0
R:R:F484	R:R:P220	4.33	1	Yes	Yes	6	8	1	2
R:R:F222	W:W:?1	5.74	1	Yes	Yes	6	0	2	2
R:R:L303	R:R:M301	5.65	0	No	No	3	4	2	1
R:R:M301	W:W:?2	4.44	1	No	Yes	4	0	1	0
R:R:D384	W:W:?1	11.73	1	Yes	Yes	8	0	2	2
R:R:E481	R:R:R482	12.79	0	No	No	5	3	1	2
R:R:F484	R:R:V488	7.87	1	Yes	No	6	6	1	2
R:R:F484	W:W:?2	4.79	1	Yes	Yes	6	0	1	0
R:R:R485	W:W:?2	12.41	0	No	Yes	5	0	1	0
R:R:D486	R:R:R485	2.38	0	No	No	4	5	2	1
R:R:E481	W:W:?2	1.04	0	No	Yes	5	0	1	0

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:N219	R:R:P220	4.89	1	Yes	Yes	7	8	1	2
R:R:L221	R:R:N219	8.24	0	No	Yes	6	7	2	1
R:R:F222	R:R:N219	4.83	1	Yes	Yes	6	7	1	1
R:R:D384	R:R:N219	4.04	1	Yes	Yes	8	7	1	1
R:R:N219	W:W:?1	3.24	1	Yes	Yes	7	0	1	0
R:R:N219	W:W:?2	4.32	1	Yes	Yes	7	0	1	2
R:R:L221	R:R:P513	8.21	0	No	No	6	8	2	2
R:R:E226	R:R:F222	7	0	No	Yes	8	6	2	1
R:R:F222	R:R:V386	9.18	1	Yes	No	6	5	1	2
R:R:F222	R:R:P513	7.22	1	Yes	No	6	8	1	2
R:R:E518	R:R:F222	4.66	1	No	Yes	7	6	1	1
R:R:F222	W:W:?1	5.74	1	Yes	Yes	6	0	1	0
R:R:S387	R:R:W281	3.71	1	Yes	Yes	8	7	1	2
R:R:I389	R:R:W281	11.74	1	No	Yes	9	7	2	2
R:R:M525	R:R:W281	5.82	1	No	Yes	5	7	1	2
R:R:F391	R:R:Y322	3.09	1	No	Yes	8	9	1	2
R:R:L325	R:R:M525	4.24	1	No	No	5	5	1	1
R:R:L325	W:W:?1	4.35	1	No	Yes	5	0	1	0
R:R:D382	R:R:Y394	6.9	0	No	Yes	9	5	2	1
R:R:D384	R:R:V386	5.84	1	Yes	No	8	5	1	2
R:R:D384	R:R:S387	5.89	1	Yes	Yes	8	8	1	1
R:R:D384	R:R:Y394	9.2	1	Yes	Yes	8	5	1	1
R:R:D384	W:W:?1	11.73	1	Yes	Yes	8	0	1	0
R:R:I389	R:R:S387	4.64	1	No	Yes	9	8	2	1
R:R:S387	W:W:?1	3.54	1	Yes	Yes	8	0	1	0
R:R:F391	R:R:Y394	5.16	1	No	Yes	8	5	1	1
R:R:F391	W:W:?1	5.74	1	No	Yes	8	0	1	0
R:R:Y394	W:W:?1	11.05	1	Yes	Yes	5	0	1	0
R:R:R400	R:R:Y397	3.09	1	Yes	Yes	9	3	1	2
R:R:F474	R:R:Y397	12.38	1	Yes	Yes	6	3	2	2
R:R:H470	R:R:R400	5.64	1	Yes	Yes	7	9	1	1
R:R:F474	R:R:R400	6.41	1	Yes	Yes	6	9	2	1
R:R:R400	W:W:?1	10.5	1	Yes	Yes	9	0	1	0
R:R:H470	R:R:L405	11.57	1	Yes	No	7	8	1	2
R:R:T466	W:W:?1	6.95	0	No	Yes	8	0	1	0
R:R:C469	R:R:N521	7.87	0	No	No	7	8	2	1
R:R:H470	R:R:N521	3.83	1	Yes	No	7	8	1	1
R:R:H470	W:W:?1	5.05	1	Yes	Yes	7	0	1	0
R:R:D473	R:R:N476	5.39	1	No	No	8	6	1	2
R:R:D473	R:R:E518	3.9	1	No	No	8	7	1	1
R:R:D473	W:W:?1	3.2	1	No	Yes	8	0	1	0
R:R:E518	W:W:?1	11.45	1	No	Yes	7	0	1	0
R:R:N521	W:W:?1	9.71	1	No	Yes	8	0	1	0
R:R:M525	W:W:?1	13.33	1	No	Yes	5	0	1	0
R:R:A524	R:R:T466	1.68	0	No	No	7	8	2	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	6XBM_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	3.09
Number of Linked Nodes	302
Number of Links	339
Number of Hubs	47
Number of Links mediated by Hubs	174
Number of Communities	9
Number of Nodes involved in Communities	66
Number of Links involved in Communities	93

Path Summary
Number Of Nodes in MetaPath	59
Number Of Links MetaPath	58
Number of Shortest Paths	69376
Length Of Smallest Path	3
Average Path Length	14.8302
Length of Longest Path	33
Minimum Path Strength	1.505
Average Path Strength	6.77513
Maximum Path Strength	20.44
Minimum Path Correlation	0.7
Average Path Correlation	0.937069
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	4.16667
Average % Of Corr. Nodes	54.3509
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	46.3149
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process
Gene Ontology	Cellular Component
SCOP2	Domain Identifier	• Transducin (heterotrimeric G protein), gamma chain • Ras-like P-loop GTPases • G protein-coupled receptor-like
SCOP2	Family Identifier	• Transducin (heterotrimeric G protein), gamma chain • Ras-like P-loop GTPases • G protein-coupled receptor-like
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	CO1
PDB Residues	W:W:?1 W:W:?2
Environment Details	Open EMBL-EBI Page
Code	CO1
Name	17-[3-(3,3-DIMETHYL-OXIRANYL)-1-METHYL-PROPYL]-10,13-DIMETHYL-2,3,4,7,8,9,10,11,12,13,14,15,16,17-TETRADECAHYDRO-1H-CYCLOPENTA[A]PHENANTHREN-3-OL
Synonyms	24,25(S)-EPOXYCHOLESTEROL
Identifier
Formula	C27 H44 O2
Molecular Weight	400.637
SMILES
PubChem	3247059
Formal Charge	0
Total Atoms	73
Total Chiral Atoms	9
Total Bonds	77
Total Aromatic Bonds	0


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	Q99835
Sequence	>6XBM_nogp_Chain_R Q C E V P L V R T D N P K S W Y E D V E G C G I Q C Q N P L F T E A E H Q D M H S Y I A A F G A V T G L C T L F T L A T F V A D W R N S N R Y P A V I L F Y V N A C F F V G S I G W L A Q F M D G A R R E I V C R A D G T M R L G E P T S N E T L S C V I I F V I V Y Y A L M A G V V W F V V L T Y A W H T S F K A L G T T Y Q P L S G K T S Y F H L L T W S L P F V L T V A I L A V A Q V D G D S V S G I C F V G Y K N Y R Y R A G F V L A P I G L V L I V G G Y F L I R G V M T L F S I K S N H P G L L S E K A A S K I N E T M L R L G I F G F L A F G F V L I T F S C H F Y D F F N Q A E W E R S F R D Y V L C Q A N V T I P S L L V E K I N L F A M F G T G I A M S T W V W T Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	4N4W	F	Protein	Frizzled	SMO	Homo sapiens	-	SANT-1	-	2.8	2014-01-22	doi.org/10.1038/ncomms5355
	6D32	F	Protein	Frizzled	SMO	Xenopus laevis	Cyclopamine	Cyclopamine	-	3.75	2018-05-23	doi.org/10.1016/j.cell.2018.04.029
	6D35	F	Protein	Frizzled	SMO	Xenopus laevis	-	Cholesterol	-	3.9	2018-05-23	doi.org/10.1016/j.cell.2018.04.029
	5L7D	F	Protein	Frizzled	SMO	Homo sapiens	-	Cholesterol	-	3.2	2016-07-20	doi.org/10.1038/nature18934
	6O3C	F	Protein	Frizzled	SMO	Mus musculus	SAG21k	Cholesterol	-	2.8	2019-07-03	doi.org/10.1038/s41586-019-1355-4
	6XBJ	F	Protein	Frizzled	SMO	Homo sapiens	-	Cholesterol	Gi1/β1/γ2	3.88	2020-09-30	doi.org/10.1038/s41589-020-0646-2
	6XBJ (No Gprot)	F	Protein	Frizzled	SMO	Homo sapiens	-	Cholesterol		3.88	2020-09-30	doi.org/10.1038/s41589-020-0646-2
	6XBK	F	Protein	Frizzled	SMO	Homo sapiens	-	Cholesterol	Gi1/β1/γ2	3.24	2020-09-30	doi.org/10.1038/s41589-020-0646-2
	6XBK (No Gprot)	F	Protein	Frizzled	SMO	Homo sapiens	-	Cholesterol		3.24	2020-09-30	doi.org/10.1038/s41589-020-0646-2
	6XBL	F	Protein	Frizzled	SMO	Homo sapiens	SAG	Cholesterol	Gi1/β1/γ2	3.96	2020-09-30	doi.org/10.1038/s41589-020-0646-2
	6XBL (No Gprot)	F	Protein	Frizzled	SMO	Homo sapiens	SAG	Cholesterol		3.96	2020-09-30	doi.org/10.1038/s41589-020-0646-2
	7ZI0	F	Protein	Frizzled	SMO	Homo sapiens	SAG	Cholesterol	-	3	2022-06-15	doi.org/10.1126/sciadv.abm5563
	6XBM	F	Protein	Frizzled	SMO	Homo sapiens	-	5LWE	Gi1/β1/γ2	3.14	2020-09-30	doi.org/10.1038/s41589-020-0646-2
	6XBM (No Gprot)	F	Protein	Frizzled	SMO	Homo sapiens	-	5LWE		3.14	2020-09-30	doi.org/10.1038/s41589-020-0646-2
	6OT0	F	Protein	Frizzled	SMO	Homo sapiens	-	25(S)-Epoxycholesterol	Gi1/β1/γ2	3.84	2019-06-12	doi.org/10.1038/s41586-019-1286-0
	6OT0 (No Gprot)	F	Protein	Frizzled	SMO	Homo sapiens	-	25(S)-Epoxycholesterol		3.84	2019-06-12	doi.org/10.1038/s41586-019-1286-0
	4JKV	F	Protein	Frizzled	SMO	Homo sapiens	Taladegib	-	-	2.45	2013-04-24	doi.org/10.1038/nature12167
	5L7I	F	Protein	Frizzled	SMO	Homo sapiens	Vismodegib	-	-	3.3	2016-07-20	doi.org/10.1038/nature18934
	5V56	F	Protein	Frizzled	SMO	Homo sapiens	TC114	-	-	2.9	2017-05-24	doi.org/10.1038/ncomms15383
	5V57	F	Protein	Frizzled	SMO	Homo sapiens	TC114	-	-	3	2017-05-24	doi.org/10.1038/ncomms15383
	4O9R	F	Protein	Frizzled	SMO	Homo sapiens	Cyclopamine	-	-	3.2	2014-03-05	doi.org/10.1038/ncomms4309
	4QIM	F	Protein	Frizzled	SMO	Homo sapiens	ANTA XV	-	-	2.61	2014-07-23	doi.org/10.1038/ncomms5355
	4QIN	F	Protein	Frizzled	SMO	Homo sapiens	SAG1.5	-	-	2.6	2014-07-23	doi.org/10.1038/ncomms5355
	8CXO	F	Protein	Frizzled	SMO	Mus musculus	-	-	-	3.7	2022-08-03	doi.org/10.1038/s41467-022-32125-2

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