psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:N219	12.11	Yes	Yes	1	0	7
2	L:L:?1	R:R:L221	4.44	Yes	No	1	0	6
3	L:L:?1	R:R:F222	3.91	Yes	Yes	1	0	6
4	L:L:?1	R:R:L303	4.44	Yes	No	0	0	3
5	L:L:?1	R:R:D384	11.97	Yes	Yes	1	0	8
6	L:L:?1	R:R:Y394	6.58	Yes	Yes	1	0	5
7	L:L:?1	R:R:K395	13.57	Yes	No	0	0	3
8	L:L:?1	R:R:D473	5.44	Yes	Yes	1	0	8
9	L:L:?1	R:R:Q477	8.54	Yes	No	1	0	6
10	L:L:?1	R:R:F484	14.65	Yes	Yes	1	0	6
11	L:L:?1	R:R:P513	3.95	Yes	No	1	0	8
12	L:L:?1	R:R:E518	11.69	Yes	No	1	0	7
13	R:R:Q192	R:R:R199	11.68	No	No	0	4	4
14	R:R:E211	R:R:Q192	8.92	No	No	0	5	4
15	R:R:C193	R:R:R199	4.18	No	No	0	9	4
16	R:R:C193	R:R:C213	7.28	No	No	0	9	9
17	R:R:P196	R:R:Q216	6.32	Yes	No	1	7	7
18	R:R:P196	R:R:P220	5.84	Yes	Yes	1	7	8
19	R:R:P196	R:R:Y487	5.56	Yes	No	0	7	4
20	R:R:P196	R:R:V488	5.3	Yes	Yes	1	7	6
21	R:R:L197	R:R:Y207	7.03	No	Yes	1	9	7
22	R:R:C213	R:R:L197	4.76	No	No	0	9	9
23	R:R:L197	R:R:V488	4.47	No	Yes	1	9	6
24	R:R:S205	R:R:T200	6.4	Yes	No	2	7	6
25	R:R:D298	R:R:T200	11.56	Yes	No	2	7	6
26	R:R:N202	R:R:P203	4.89	Yes	No	0	5	4
27	R:R:K204	R:R:N202	5.6	No	Yes	0	3	5
28	R:R:N202	R:R:S205	7.45	Yes	Yes	2	5	7
29	R:R:D298	R:R:N202	8.08	Yes	Yes	2	7	5
30	R:R:P203	R:R:W206	6.76	No	No	0	4	4
31	R:R:K204	R:R:T307	6.01	No	Yes	0	3	6
32	R:R:K204	R:R:S308	6.12	No	No	0	3	8
33	R:R:R296	R:R:S205	5.27	Yes	Yes	2	6	7
34	R:R:D298	R:R:S205	8.83	Yes	Yes	2	7	7
35	R:R:S205	R:R:T300	4.8	Yes	Yes	2	7	7
36	R:R:G212	R:R:W206	8.44	No	No	0	7	4
37	R:R:E208	R:R:Y207	24.69	No	Yes	0	4	7
38	R:R:F484	R:R:Y207	5.16	Yes	Yes	1	6	7
39	R:R:V488	R:R:Y207	8.83	Yes	Yes	1	6	7
40	R:R:C213	R:R:V210	5.12	No	No	0	9	5
41	R:R:I215	R:R:M301	5.83	No	No	0	5	4
42	R:R:F484	R:R:I215	3.77	Yes	No	0	6	5
43	R:R:P220	R:R:Q216	6.32	Yes	No	1	8	7
44	R:R:C217	R:R:C295	7.28	No	No	0	9	9
45	R:R:E224	R:R:Q218	8.92	No	No	1	4	5
46	R:R:H227	R:R:Q218	16.07	Yes	No	1	7	5
47	R:R:Q218	R:R:S385	4.33	No	No	1	5	7
48	R:R:N219	R:R:P220	6.52	Yes	Yes	1	7	8
49	R:R:L221	R:R:N219	5.49	No	Yes	1	6	7
50	R:R:F222	R:R:N219	8.46	Yes	Yes	1	6	7
51	R:R:D384	R:R:N219	5.39	Yes	Yes	1	8	7
52	R:R:N219	R:R:V386	4.43	Yes	Yes	1	7	5
53	R:R:F484	R:R:P220	5.78	Yes	Yes	1	6	8
54	R:R:F222	R:R:L221	4.87	Yes	No	1	6	6
55	R:R:E226	R:R:F222	8.16	Yes	Yes	1	8	6
56	R:R:F222	R:R:V386	3.93	Yes	Yes	1	6	5
57	R:R:F222	R:R:R512	5.34	Yes	No	1	6	6
58	R:R:F222	R:R:P513	10.11	Yes	No	1	6	8
59	R:R:F222	R:R:L515	7.31	Yes	No	1	6	5
60	R:R:E226	R:R:T223	9.88	Yes	No	0	8	5
61	R:R:E224	R:R:H227	4.92	No	Yes	1	4	7
62	R:R:E224	R:R:Q228	15.29	No	No	0	4	3
63	R:R:E226	R:R:R512	13.96	Yes	No	1	8	6
64	R:R:E226	R:R:L515	6.63	Yes	No	1	8	5
65	R:R:H227	R:R:H231	7.17	Yes	No	0	7	7
66	R:R:H227	R:R:S385	6.97	Yes	No	1	7	7
67	R:R:H227	R:R:V386	6.92	Yes	Yes	1	7	5
68	R:R:D229	R:R:K519	5.53	No	No	0	6	7
69	R:R:L515	R:R:M230	4.24	No	No	0	5	7
70	R:R:K519	R:R:M230	4.32	No	No	0	7	7
71	R:R:H231	R:R:R290	25.95	No	No	0	7	9
72	R:R:F237	R:R:Y233	8.25	Yes	No	0	4	6
73	R:R:K519	R:R:Y233	14.33	No	No	0	7	6
74	R:R:I234	R:R:W281	8.22	No	Yes	3	7	7
75	R:R:I234	R:R:Q284	5.49	No	Yes	3	7	9
76	R:R:F285	R:R:I234	5.02	Yes	No	3	8	7
77	R:R:A235	R:R:F285	5.55	No	Yes	0	5	8
78	R:R:F237	R:R:F523	7.5	Yes	No	0	4	6
79	R:R:F237	R:R:F526	6.43	Yes	Yes	0	4	9
80	R:R:F526	R:R:G238	6.02	Yes	No	0	9	7
81	R:R:F526	R:R:T241	11.67	Yes	No	0	9	7
82	R:R:I530	R:R:T241	6.08	No	No	0	7	7
83	R:R:C244	R:R:S533	5.16	No	No	0	6	9
84	R:R:F275	R:R:T245	5.19	Yes	No	0	5	8
85	R:R:F275	R:R:L246	14.61	Yes	No	0	5	6
86	R:R:F247	R:R:T251	7.78	No	No	7	8	9
87	R:R:F247	R:R:V536	3.93	No	Yes	7	8	8
88	R:R:F247	R:R:W537	7.02	No	No	0	8	8
89	R:R:N271	R:R:T248	13.16	No	No	0	9	8
90	R:R:T248	R:R:V536	6.35	No	Yes	0	8	8
91	R:R:F268	R:R:L249	4.87	Yes	No	0	8	6
92	R:R:T251	R:R:V536	6.35	No	Yes	7	9	8
93	R:R:T251	R:R:W545	13.34	No	Yes	0	9	9
94	R:R:F252	R:R:F268	12.86	No	Yes	0	9	8
95	R:R:D255	R:R:N258	6.73	No	No	0	8	8
96	R:R:D255	R:R:S259	4.42	No	No	0	8	8
97	R:R:D255	R:R:I544	5.6	No	No	0	8	6
98	R:R:N260	R:R:W256	14.69	No	No	0	7	7
99	R:R:F268	R:R:W256	9.02	Yes	No	0	8	7
100	R:R:V265	R:R:Y262	10.09	No	Yes	0	8	9
101	R:R:I266	R:R:Y262	4.84	No	Yes	0	8	9
102	R:R:S358	R:R:Y262	7.63	No	Yes	0	6	9
103	R:R:F360	R:R:Y262	7.22	No	Yes	0	9	9
104	R:R:I266	R:R:V334	4.61	No	No	0	8	7
105	R:R:I266	R:R:L335	4.28	No	No	0	8	8
106	R:R:L267	R:R:L335	5.54	No	No	0	8	8
107	R:R:L267	R:R:W535	18.22	No	No	0	8	9
108	R:R:F268	R:R:Y269	11.35	Yes	Yes	0	8	8
109	R:R:W331	R:R:Y269	18.33	Yes	Yes	5	9	8
110	R:R:H361	R:R:Y269	9.8	Yes	Yes	5	9	8
111	R:R:W365	R:R:Y269	3.86	Yes	Yes	5	9	8
112	R:R:M532	R:R:V270	4.56	Yes	No	0	8	8
113	R:R:M532	R:R:N271	4.21	Yes	No	0	8	9
114	R:R:C273	R:R:G328	3.92	No	No	0	9	8
115	R:R:F274	R:R:T528	9.08	No	No	0	9	7
116	R:R:F274	R:R:G529	10.54	No	No	0	9	9
117	R:R:F275	R:R:I279	5.02	Yes	No	0	5	5
118	R:R:F526	R:R:S278	3.96	Yes	No	0	9	8
119	R:R:I389	R:R:W281	8.22	No	Yes	0	9	7
120	R:R:L522	R:R:W281	6.83	No	Yes	0	7	7
121	R:R:M525	R:R:W281	6.98	No	Yes	3	5	7
122	R:R:F526	R:R:W281	4.01	Yes	Yes	3	9	7
123	R:R:F285	R:R:Q284	17.57	Yes	Yes	3	8	9
124	R:R:Q284	R:R:R290	18.69	Yes	No	0	9	9
125	R:R:G388	R:R:Q284	8.22	No	Yes	0	9	9
126	R:R:E292	R:R:T311	7.06	No	No	4	5	7
127	R:R:E292	R:R:S313	10.06	No	No	4	5	7
128	R:R:I293	R:R:I317	8.83	No	No	0	8	7
129	R:R:R296	R:R:T300	3.88	Yes	Yes	2	6	7
130	R:R:R296	R:R:T307	6.47	Yes	Yes	0	6	6
131	R:R:E310	R:R:R296	12.79	No	Yes	0	8	6
132	R:R:A297	R:R:E310	4.53	No	No	0	5	8
133	R:R:D298	R:R:T300	8.67	Yes	Yes	2	7	7
134	R:R:L303	R:R:M301	4.24	No	No	0	3	4
135	R:R:E305	R:R:R302	10.47	Yes	No	4	7	6
136	R:R:R302	R:R:T311	3.88	No	No	4	6	7
137	R:R:C314	R:R:R302	8.36	No	No	4	9	6
138	R:R:D382	R:R:L303	6.79	No	No	0	9	3
139	R:R:E305	R:R:T307	11.29	Yes	Yes	0	7	6
140	R:R:E305	R:R:E310	5.07	Yes	No	0	7	8
141	R:R:C314	R:R:E305	4.56	No	Yes	4	9	7
142	R:R:P306	R:R:V315	5.3	No	No	0	5	7
143	R:R:N309	R:R:S308	5.96	No	No	0	6	8
144	R:R:S313	R:R:T311	7.99	No	No	4	7	7
145	R:R:L312	R:R:V315	4.47	No	No	0	7	7
146	R:R:C314	R:R:C390	7.28	No	Yes	0	9	9
147	R:R:V315	R:R:V381	4.81	No	No	0	7	8
148	R:R:F318	R:R:Y322	7.22	Yes	Yes	6	9	9
149	R:R:F318	R:R:I375	11.3	Yes	Yes	6	9	7
150	R:R:F318	R:R:V381	17.04	Yes	No	0	9	8
151	R:R:T372	R:R:V319	4.76	No	No	0	9	7
152	R:R:M326	R:R:Y322	10.78	No	Yes	0	8	9
153	R:R:L371	R:R:Y322	9.38	No	Yes	0	8	9
154	R:R:T372	R:R:Y322	3.75	No	Yes	0	9	9
155	R:R:I375	R:R:Y322	8.46	Yes	Yes	6	7	9
156	R:R:F391	R:R:Y322	4.13	Yes	Yes	0	8	9
157	R:R:F403	R:R:Y322	5.16	Yes	Yes	6	8	9
158	R:R:W365	R:R:Y323	6.75	Yes	Yes	0	9	8
159	R:R:P368	R:R:Y323	9.74	No	Yes	0	9	8
160	R:R:T372	R:R:Y323	3.75	No	Yes	0	9	8
161	R:R:M326	R:R:P407	5.03	No	No	0	8	9
162	R:R:V329	R:R:V411	9.62	No	No	0	6	5
163	R:R:V334	R:R:W331	7.36	No	Yes	0	7	9
164	R:R:H361	R:R:W331	4.23	Yes	Yes	5	9	9
165	R:R:T364	R:R:W331	23.04	No	Yes	5	9	9
166	R:R:W331	R:R:W365	11.25	Yes	Yes	5	9	9
167	R:R:F332	R:R:T336	5.19	No	Yes	0	9	7
168	R:R:F332	R:R:F460	5.36	No	No	0	9	5
169	R:R:F360	R:R:V334	11.8	No	No	0	9	7
170	R:R:G415	R:R:T336	5.46	No	Yes	0	8	7
171	R:R:F418	R:R:T336	6.49	Yes	Yes	0	8	7
172	R:R:L419	R:R:T336	7.37	No	Yes	0	7	7
173	R:R:T341	R:R:Y337	4.99	No	No	0	6	7
174	R:R:F360	R:R:Y337	4.13	No	No	0	9	7
175	R:R:F418	R:R:Y337	15.47	Yes	No	0	8	7
176	R:R:G422	R:R:W339	4.22	No	Yes	0	8	9
177	R:R:V423	R:R:W339	4.9	No	Yes	0	7	9
178	R:R:L452	R:R:W339	9.11	No	Yes	0	8	9
179	R:R:G453	R:R:W339	7.04	No	Yes	0	5	9
180	R:R:H340	R:R:T341	6.85	No	No	0	7	6
181	R:R:F418	R:R:H340	11.31	Yes	No	0	8	7
182	R:R:H340	R:R:R421	11.28	No	No	0	7	7
183	R:R:M449	R:R:S342	6.13	Yes	No	0	9	8
184	R:R:F343	R:R:T425	7.78	No	No	0	9	7
185	R:R:H361	R:R:S358	5.58	Yes	No	0	9	6
186	R:R:H361	R:R:W365	7.41	Yes	Yes	5	9	9
187	R:R:T364	R:R:W365	9.7	No	Yes	5	9	9
188	R:R:F369	R:R:V373	7.87	No	No	0	7	7
189	R:R:A374	R:R:F403	4.16	No	Yes	0	5	8
190	R:R:I375	R:R:V392	12.29	Yes	No	6	7	9
191	R:R:F403	R:R:I375	12.56	Yes	Yes	6	8	7
192	R:R:Q380	R:R:V378	4.3	No	No	8	7	5
193	R:R:V378	R:R:Y399	8.83	No	No	8	5	5
194	R:R:N396	R:R:Q380	13.2	No	No	0	7	7
195	R:R:Q380	R:R:Y399	23.67	No	No	8	7	5
196	R:R:D382	R:R:Y394	5.75	No	Yes	0	9	5
197	R:R:C390	R:R:G383	3.92	Yes	No	0	9	8
198	R:R:D384	R:R:V386	8.76	Yes	Yes	1	8	5
199	R:R:D384	R:R:S387	7.36	Yes	No	0	8	8
200	R:R:D384	R:R:Y394	4.6	Yes	Yes	1	8	5
201	R:R:I389	R:R:S387	4.64	No	No	0	9	8
202	R:R:F391	R:R:V392	5.24	Yes	No	0	8	9
203	R:R:F391	R:R:Y394	8.25	Yes	Yes	0	8	5
204	R:R:F391	R:R:V404	7.87	Yes	No	0	8	7
205	R:R:F403	R:R:V392	3.93	Yes	No	6	8	9
206	R:R:K395	R:R:N396	8.39	No	No	0	3	7
207	R:R:N396	R:R:R398	10.85	No	No	0	7	1
208	R:R:R398	R:R:Y397	4.12	No	Yes	0	1	3
209	R:R:F474	R:R:Y397	5.16	No	Yes	0	6	3
210	R:R:Q477	R:R:Y397	16.91	No	Yes	1	6	3
211	R:R:E481	R:R:Y397	6.73	No	Yes	1	5	3
212	R:R:H470	R:R:R400	5.64	No	No	0	7	9
213	R:R:D473	R:R:R400	10.72	Yes	No	0	8	9
214	R:R:A401	R:R:F474	5.55	No	No	0	6	6
215	R:R:F467	R:R:L405	7.31	No	No	0	7	8
216	R:R:F474	R:R:L405	4.87	No	No	0	6	8
217	R:R:F467	R:R:I408	5.02	No	No	0	7	7
218	R:R:L412	R:R:L464	6.92	Yes	No	0	7	4
219	R:R:F467	R:R:L412	4.87	No	Yes	0	7	7
220	R:R:F418	R:R:V414	3.93	Yes	No	0	8	5
221	R:R:F418	R:R:Y417	5.16	Yes	No	0	8	5
222	R:R:R421	R:R:Y417	11.32	No	No	0	7	5
223	R:R:F457	R:R:L419	9.74	No	No	0	4	7
224	R:R:M424	R:R:V423	4.56	No	No	0	5	7
225	R:R:F457	R:R:V423	3.93	No	No	0	4	7
226	R:R:F427	R:R:S431	7.93	No	No	0	7	5
227	R:R:N432	R:R:S428	4.47	No	No	0	6	5
228	R:R:F455	R:R:R451	4.28	Yes	No	0	8	9
229	R:R:R451	R:R:T538	6.47	No	No	0	9	8
230	R:R:L452	R:R:W535	6.83	No	No	0	8	9
231	R:R:F455	R:R:T534	5.19	Yes	No	0	8	7
232	R:R:F455	R:R:W535	13.03	Yes	No	0	8	9
233	R:R:A524	R:R:F462	4.16	No	No	0	7	7
234	R:R:F462	R:R:T528	5.19	No	No	0	7	7
235	R:R:A524	R:R:I465	6.5	No	No	0	7	5
236	R:R:N521	R:R:T466	7.31	No	No	0	8	8
237	R:R:C469	R:R:N521	12.6	No	No	0	7	8
238	R:R:H470	R:R:N521	7.65	No	No	0	7	8
239	R:R:F471	R:R:F475	9.65	No	No	0	4	3
240	R:R:N476	R:R:Y472	12.79	No	Yes	1	6	7
241	R:R:W480	R:R:Y472	6.75	Yes	Yes	1	9	7
242	R:R:S514	R:R:Y472	3.82	No	Yes	1	7	7
243	R:R:V517	R:R:Y472	8.83	No	Yes	1	6	7
244	R:R:D473	R:R:W480	4.47	Yes	Yes	1	8	9
245	R:R:D473	R:R:E518	11.69	Yes	No	1	8	7
246	R:R:F475	R:R:N476	4.83	No	No	0	3	6
247	R:R:N476	R:R:W480	5.65	No	Yes	1	6	9
248	R:R:E481	R:R:Q477	5.1	No	No	1	5	6
249	R:R:E479	R:R:R482	9.3	No	No	0	2	3
250	R:R:E479	R:R:N511	10.52	No	No	0	2	4
251	R:R:N511	R:R:W480	4.52	No	Yes	0	4	9
252	R:R:P513	R:R:W480	22.97	No	Yes	1	8	9
253	R:R:E481	R:R:R485	6.98	No	No	0	5	5
254	R:R:K510	R:R:S483	7.65	No	No	0	4	7
255	R:R:N511	R:R:S483	7.45	No	No	0	4	7
256	R:R:F484	R:R:V488	7.87	Yes	Yes	1	6	6
257	R:R:Q491	R:R:Y487	14.65	No	No	0	4	4
258	R:R:I509	R:R:Y487	8.46	No	No	0	4	4
259	R:R:C490	R:R:C507	7.28	No	No	0	9	9
260	R:R:C507	R:R:Q491	10.68	No	No	0	9	4
261	R:R:S514	R:R:V517	6.46	No	No	1	7	6
262	R:R:I520	R:R:L516	5.71	No	No	0	5	4
263	R:R:F526	R:R:M525	13.68	Yes	No	3	9	5
264	R:R:G527	R:R:I530	5.29	No	No	0	5	7
265	R:R:T534	R:R:W537	16.98	No	No	0	7	8
266	R:R:T541	R:R:V536	4.76	No	Yes	0	8	8
267	R:R:T538	R:R:T541	4.71	No	No	0	8	8
268	R:R:C550	R:R:R547	4.18	No	No	0	4	6
269	R:R:A327	R:R:P368	3.74	No	No	0	9	9
270	R:R:F274	R:R:M532	3.73	No	Yes	0	9	8
271	R:R:G242	R:R:S278	3.71	No	No	0	4	8
272	R:R:F275	R:R:L249	3.65	Yes	No	0	5	6
273	R:R:F285	R:R:L282	3.65	Yes	No	0	8	7
274	R:R:F318	R:R:L376	3.65	Yes	No	0	9	8
275	R:R:F462	R:R:L458	3.65	No	No	0	7	6
276	R:R:L543	R:R:R547	3.64	No	No	0	4	6
277	R:R:P196	R:R:V195	3.53	Yes	No	0	7	4
278	R:R:G280	R:R:I279	3.53	No	No	0	7	5
279	R:R:M449	R:R:W339	3.49	Yes	Yes	0	9	9
280	R:R:C217	R:R:V294	3.42	No	No	0	9	8
281	R:R:C390	R:R:V381	3.42	Yes	No	0	9	8
282	R:R:G409	R:R:L412	3.42	No	Yes	0	4	7
283	R:R:A324	R:R:V276	3.39	No	No	0	7	5
284	R:R:M449	R:R:P263	3.35	Yes	No	0	9	9
285	R:R:D382	R:R:G393	3.35	No	No	0	9	9
286	R:R:C390	R:R:I293	3.27	Yes	No	0	9	8
287	R:R:A289	R:R:M286	3.22	No	No	0	7	4
288	R:R:A459	R:R:M532	3.22	No	Yes	0	7	8
289	R:R:V333	R:R:V411	3.21	No	No	0	9	5
290	R:R:T364	R:R:V330	3.17	No	No	0	9	6
291	R:R:I530	R:R:V240	3.07	No	No	0	7	4
292	R:R:I293	R:R:V294	3.07	No	No	0	8	8
293	R:R:I544	R:R:T541	3.04	No	No	0	6	8
294	R:R:F343	R:R:W339	3.01	No	Yes	0	9	9
295	R:R:F460	R:R:G416	3.01	No	No	0	5	5
296	R:R:M449	R:R:T448	3.01	Yes	No	0	9	8
297	R:R:F460	R:R:G461	3.01	No	No	0	5	5
298	R:R:L412	R:R:V463	2.98	Yes	No	0	7	7
299	R:R:I316	R:R:I320	2.94	No	No	0	5	5
300	R:R:N446	R:R:T448	2.92	No	No	0	7	8
301	R:R:E194	R:R:V195	2.85	No	No	0	6	4
302	R:R:I316	R:R:L312	2.85	No	No	0	5	7
303	R:R:I413	R:R:L410	2.85	No	No	0	3	4
304	R:R:A264	R:R:R261	2.77	No	No	0	9	7
305	R:R:L362	R:R:L363	2.77	No	No	0	5	4
306	R:R:A478	R:R:Y397	2.67	No	Yes	0	3	3
307	R:R:E447	R:R:L450	2.65	No	No	0	6	6
308	R:R:C273	R:R:W365	2.61	No	Yes	0	9	9
309	R:R:A250	R:R:W545	2.59	No	Yes	0	6	9
310	R:R:A254	R:R:W545	2.59	No	Yes	0	8	9
311	R:R:R551	R:R:T548	2.59	No	No	0	7	6
312	R:R:F343	R:R:I429	2.51	No	No	0	9	7
313	R:R:F455	R:R:I454	2.51	Yes	No	0	8	6
314	R:R:T548	R:R:W545	2.43	No	Yes	0	6	9
315	R:R:N258	R:R:R261	2.41	No	No	0	8	7
316	R:R:E447	R:R:R451	2.33	No	No	0	6	9
317	R:R:A324	R:R:G277	1.95	No	No	0	7	6
318	R:R:A283	R:R:G280	1.95	No	No	0	5	7
319	R:R:A401	R:R:G402	1.95	No	No	0	6	5
320	R:R:A406	R:R:G402	1.95	No	No	0	5	5
321	R:R:A338	R:R:P263	1.87	No	No	0	8	9
322	R:R:A379	R:R:P306	1.87	No	No	0	6	5
323	R:R:G280	R:R:V321	1.84	No	No	0	7	8
324	R:R:G214	R:R:T200	1.82	No	No	0	8	6
325	R:R:G214	R:R:T300	1.82	No	Yes	0	8	7
326	R:R:G304	R:R:T307	1.82	No	Yes	0	5	6
327	R:R:C244	R:R:V240	1.71	No	No	0	6	4
328	R:R:G456	R:R:L335	1.71	No	No	0	7	8
329	R:R:G456	R:R:L419	1.71	No	No	0	7	7
330	R:R:A225	R:R:T223	1.68	No	No	0	4	5
331	R:R:A540	R:R:T538	1.68	No	No	0	8	8
332	R:R:L367	R:R:P368	1.64	No	No	0	5	9
333	R:R:C469	R:R:I520	1.64	No	No	0	7	5
334	R:R:A531	R:R:M532	1.61	No	Yes	0	6	8
335	R:R:V329	R:R:V330	1.6	No	No	0	6	6
336	R:R:V333	R:R:V414	1.6	No	No	0	9	5
337	R:R:T300	R:R:V198	1.59	Yes	No	0	7	6
338	R:R:A239	R:R:L282	1.58	No	No	0	4	7
339	R:R:A272	R:R:L249	1.58	No	No	0	4	6
340	R:R:I429	R:R:S443	1.55	No	No	0	7	6
341	R:R:I320	R:R:V276	1.54	No	No	0	5	5
342	R:R:I413	R:R:V414	1.54	No	No	0	3	5
343	R:R:A492	R:R:E194	1.51	No	No	0	5	6
344	R:R:L325	R:R:V404	1.49	No	No	0	5	7
345	R:R:I420	R:R:M424	1.46	No	No	0	5	5
346	R:R:A441	R:R:H433	1.46	No	No	0	8	8
347	R:R:I445	R:R:M449	1.46	No	Yes	0	9	9
348	R:R:N493	R:R:T495	1.46	No	No	0	5	4
349	R:R:E194	R:R:V494	1.43	No	No	0	6	5
350	R:R:Q491	R:R:V494	1.43	No	No	0	4	5
351	R:R:K430	R:R:L426	1.41	No	No	0	8	9
352	R:R:A236	R:R:F237	1.39	No	Yes	0	4	4
353	R:R:C295	R:R:R291	1.39	No	No	0	9	5
354	R:R:L363	R:R:L367	1.38	No	No	0	4	5
355	R:R:F268	R:R:V253	1.31	Yes	No	0	8	5
356	R:R:F369	R:R:V370	1.31	No	No	0	7	5
357	R:R:D209	R:R:E208	1.3	No	No	0	4	4
358	R:R:L543	R:R:R546	1.21	No	No	0	4	5
359	R:R:D201	R:R:R199	1.19	No	No	0	5	4
360	R:R:L362	R:R:Y359	1.17	No	No	0	5	7
361	R:R:F369	R:R:Y323	1.03	No	Yes	0	7	8

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	L:L:?1	8.44083	12	1	0
2	R:R:P196	5.31	5	1	7
3	R:R:N202	6.505	4	2	5
4	R:R:S205	6.55	5	2	7
5	R:R:Y207	11.4275	4	1	7
6	R:R:N219	7.06667	6	1	7
7	R:R:P220	6.115	4	1	8
8	R:R:F222	6.51125	8	1	6
9	R:R:E226	9.6575	4	1	8
10	R:R:H227	8.41	5	1	7
11	R:R:F237	5.8925	4	0	4
12	R:R:Y262	7.445	4	0	9
13	R:R:F268	7.882	5	0	8
14	R:R:Y269	10.835	4	5	8
15	R:R:F275	7.1175	4	0	5
16	R:R:W281	6.852	5	3	7
17	R:R:Q284	12.4925	4	3	9
18	R:R:F285	7.9475	4	3	8
19	R:R:R296	7.1025	4	2	6
20	R:R:D298	9.285	4	2	7
21	R:R:T300	4.152	5	2	7
22	R:R:E305	7.8475	4	4	7
23	R:R:T307	6.3975	4	0	6
24	R:R:F318	9.8025	4	6	9
25	R:R:Y322	6.98286	7	6	9
26	R:R:Y323	5.3175	4	0	8
27	R:R:W331	12.842	5	5	9
28	R:R:T336	6.1275	4	0	7
29	R:R:W339	5.295	6	0	9
30	R:R:H361	6.755	4	5	9
31	R:R:W365	6.93	6	5	9
32	R:R:I375	11.1525	4	6	7
33	R:R:D384	7.616	5	1	8
34	R:R:V386	6.01	4	1	5
35	R:R:C390	4.4725	4	0	9
36	R:R:F391	6.3725	4	0	8
37	R:R:Y394	6.295	4	1	5
38	R:R:Y397	7.118	5	1	3
39	R:R:F403	6.4525	4	6	8
40	R:R:L412	4.5475	4	0	7
41	R:R:F418	8.472	5	0	8
42	R:R:M449	3.488	5	0	9
43	R:R:F455	6.2525	4	0	8
44	R:R:Y472	8.0475	4	1	7
45	R:R:D473	8.08	4	1	8
46	R:R:W480	8.872	5	1	9
47	R:R:F484	7.446	5	1	6
48	R:R:V488	6.6175	4	1	6
49	R:R:F526	7.62833	6	3	9
50	R:R:M532	3.466	5	0	8
51	R:R:V536	5.3475	4	7	8
52	R:R:W545	5.2375	4	0	9

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:F484	36.3034	14.65	Yes	Yes	1	0	6
2	R:R:F484	R:R:Y207	10.1808	5.16	Yes	Yes	1	6	7
3	R:R:C213	R:R:L197	13.5675	4.76	No	No	0	9	9
4	R:R:F484	R:R:V488	16.1844	7.87	Yes	Yes	1	6	6
5	L:L:?1	R:R:N219	11.274	12.11	Yes	Yes	1	0	7
6	R:R:N219	R:R:P220	19.2214	6.52	Yes	Yes	1	7	8
7	R:R:P196	R:R:P220	23.6491	5.84	Yes	Yes	1	7	8
8	R:R:P196	R:R:Y487	17.3194	5.56	Yes	No	0	7	4
9	L:L:?1	R:R:Y394	71.3935	6.58	Yes	Yes	1	0	5
10	R:R:F391	R:R:Y394	100	8.25	Yes	Yes	0	8	5
11	R:R:F391	R:R:Y322	98.5415	4.13	Yes	Yes	0	8	9
12	R:R:F318	R:R:Y322	46.8834	7.22	Yes	Yes	6	9	9
13	R:R:F318	R:R:V381	45.9545	17.04	Yes	No	0	9	8
14	R:R:C390	R:R:V381	38.1794	3.42	Yes	No	0	9	8
15	R:R:C314	R:R:C390	31.5835	7.28	No	Yes	0	9	9
16	R:R:C314	R:R:E305	26.9888	4.56	No	Yes	4	9	7
17	R:R:E305	R:R:T307	17.0011	11.29	Yes	Yes	0	7	6
18	R:R:H227	R:R:V386	11.2923	6.92	Yes	Yes	1	7	5
19	R:R:D384	R:R:S387	20.4843	7.36	Yes	No	0	8	8
20	R:R:I389	R:R:S387	19.6598	4.64	No	No	0	9	8
21	R:R:I389	R:R:W281	18.8535	8.22	No	Yes	0	9	7
22	R:R:F526	R:R:W281	11.3706	4.01	Yes	Yes	3	9	7
23	R:R:T372	R:R:Y322	91.3612	3.75	No	Yes	0	9	9
24	R:R:T372	R:R:Y323	90.7559	3.75	No	Yes	0	9	8
25	R:R:W365	R:R:Y323	87.4162	6.75	Yes	Yes	0	9	8
26	R:R:W365	R:R:Y269	10.5565	3.86	Yes	Yes	5	9	8
27	R:R:F268	R:R:Y269	13.7214	11.35	Yes	Yes	0	8	8
28	R:R:W331	R:R:W365	67.5581	11.25	Yes	Yes	5	9	9
29	R:R:V334	R:R:W331	71.8814	7.36	No	Yes	0	7	9
30	R:R:I266	R:R:V334	57.6356	4.61	No	No	0	8	7
31	R:R:I266	R:R:L335	58.2775	4.28	No	No	0	8	8
32	R:R:L267	R:R:L335	55.5535	5.54	No	No	0	8	8
33	R:R:L267	R:R:W535	54.8986	18.22	No	No	0	8	9
34	R:R:F455	R:R:W535	45.2083	13.03	Yes	No	0	8	9
35	R:R:F455	R:R:T534	20.4686	5.19	Yes	No	0	8	7
36	R:R:T534	R:R:W537	19.618	16.98	No	No	0	7	8
37	R:R:F247	R:R:W537	18.7779	7.02	No	No	0	8	8
38	R:R:F455	R:R:R451	23.3178	4.28	Yes	No	0	8	9
39	R:R:R451	R:R:T538	20.8417	6.47	No	No	0	9	8
40	R:R:T538	R:R:T541	19.1771	4.71	No	No	0	8	8
41	R:R:T541	R:R:V536	13.2231	4.76	No	Yes	0	8	8
42	R:R:F247	R:R:V536	12.7038	3.93	No	Yes	7	8	8
43	R:R:T248	R:R:V536	24.0118	6.35	No	Yes	0	8	8
44	R:R:N271	R:R:T248	22.1958	13.16	No	No	0	9	8
45	R:R:F360	R:R:V334	14.765	11.8	No	No	0	9	7
46	R:R:M532	R:R:N271	20.3747	4.21	Yes	No	0	8	9
47	R:R:F274	R:R:M532	13.0378	3.73	No	Yes	0	9	8
48	R:R:F360	R:R:Y337	14.4206	4.13	No	No	0	9	7
49	R:R:F418	R:R:Y337	10.9636	15.47	Yes	No	0	8	7
50	R:R:L452	R:R:W535	14.0267	6.83	No	No	0	8	9
51	R:R:L452	R:R:W339	13.1996	9.11	No	Yes	0	8	9
52	L:L:?1	R:R:Q477	16.8602	8.54	Yes	No	1	0	6
53	R:R:Q477	R:R:Y397	13.9223	16.91	No	Yes	1	6	3
54	R:R:F474	R:R:Y397	11.2192	5.16	No	Yes	0	6	3
55	L:L:?1	R:R:D473	17.7186	5.44	Yes	Yes	1	0	8
56	R:R:D473	R:R:W480	10.3191	4.47	Yes	Yes	1	8	9
57	L:L:?1	R:R:P513	10.8748	3.95	Yes	No	1	0	8
58	R:R:P513	R:R:W480	11.3836	22.97	No	Yes	1	8	9
59	R:R:Q491	R:R:Y487	11.6211	14.65	No	No	0	4	4
60	R:R:P196	R:R:V195	11.441	3.53	Yes	No	0	7	4
61	R:R:D384	R:R:Y394	27.2941	4.6	Yes	Yes	1	8	5

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:?1	R:R:N219	12.11	1	Yes	Yes	0	7	0	1
L:L:?1	R:R:L221	4.44	1	Yes	No	0	6	0	1
L:L:?1	R:R:F222	3.91	1	Yes	Yes	0	6	0	1
L:L:?1	R:R:L303	4.44	1	Yes	No	0	3	0	1
L:L:?1	R:R:D384	11.97	1	Yes	Yes	0	8	0	1
L:L:?1	R:R:Y394	6.58	1	Yes	Yes	0	5	0	1
L:L:?1	R:R:K395	13.57	1	Yes	No	0	3	0	1
L:L:?1	R:R:D473	5.44	1	Yes	Yes	0	8	0	1
L:L:?1	R:R:Q477	8.54	1	Yes	No	0	6	0	1
L:L:?1	R:R:F484	14.65	1	Yes	Yes	0	6	0	1
L:L:?1	R:R:P513	3.95	1	Yes	No	0	8	0	1
L:L:?1	R:R:E518	11.69	1	Yes	No	0	7	0	1
R:R:F484	R:R:Y207	5.16	1	Yes	Yes	6	7	1	2
R:R:V488	R:R:Y207	8.83	1	Yes	Yes	6	7	2	2
R:R:I215	R:R:M301	5.83	0	No	No	5	4	2	2
R:R:F484	R:R:I215	3.77	1	Yes	No	6	5	1	2
R:R:N219	R:R:P220	6.52	1	Yes	Yes	7	8	1	2
R:R:L221	R:R:N219	5.49	1	No	Yes	6	7	1	1
R:R:F222	R:R:N219	8.46	1	Yes	Yes	6	7	1	1
R:R:D384	R:R:N219	5.39	1	Yes	Yes	8	7	1	1
R:R:N219	R:R:V386	4.43	1	Yes	Yes	7	5	1	2
R:R:F484	R:R:P220	5.78	1	Yes	Yes	6	8	1	2
R:R:F222	R:R:L221	4.87	1	Yes	No	6	6	1	1
R:R:E226	R:R:F222	8.16	1	Yes	Yes	8	6	2	1
R:R:F222	R:R:V386	3.93	1	Yes	Yes	6	5	1	2
R:R:F222	R:R:R512	5.34	1	Yes	No	6	6	1	2
R:R:F222	R:R:P513	10.11	1	Yes	No	6	8	1	1
R:R:F222	R:R:L515	7.31	1	Yes	No	6	5	1	2
R:R:E226	R:R:R512	13.96	1	Yes	No	8	6	2	2
R:R:E226	R:R:L515	6.63	1	Yes	No	8	5	2	2
R:R:L303	R:R:M301	4.24	0	No	No	3	4	1	2
R:R:D382	R:R:L303	6.79	0	No	No	9	3	2	1
R:R:D382	R:R:Y394	5.75	0	No	Yes	9	5	2	1
R:R:D384	R:R:V386	8.76	1	Yes	Yes	8	5	1	2
R:R:D384	R:R:S387	7.36	1	Yes	No	8	8	1	2
R:R:D384	R:R:Y394	4.6	1	Yes	Yes	8	5	1	1
R:R:F391	R:R:Y394	8.25	0	Yes	Yes	8	5	2	1
R:R:K395	R:R:N396	8.39	0	No	No	3	7	1	2
R:R:Q477	R:R:Y397	16.91	1	No	Yes	6	3	1	2
R:R:E481	R:R:Y397	6.73	1	No	Yes	5	3	2	2
R:R:D473	R:R:R400	10.72	1	Yes	No	8	9	1	2
R:R:D473	R:R:W480	4.47	1	Yes	Yes	8	9	1	2
R:R:D473	R:R:E518	11.69	1	Yes	No	8	7	1	1
R:R:E481	R:R:Q477	5.1	1	No	No	5	6	2	1
R:R:P513	R:R:W480	22.97	1	No	Yes	8	9	1	2
R:R:F484	R:R:V488	7.87	1	Yes	Yes	6	6	1	2

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

Similarity	Network Type	Name	Ligand	Description
88.89	Single	4QIN	SAG1.5	4QIN-SMO-SAG1.5
88.89	Single	6O3C	SAG21k	6O3C-SMO-SAG21k-Cholesterol
80.00	Single	7ZI0	SAG	7ZI0-SMO-SAG-Cholesterol
63.64	Single	6XBL	SAG	6XBL-SMO-SAG-Cholesterol-Gi1/β1/γ2
50.00	Single	4XNW	MRS2500	4XNW-P2Y₁-MRS2500
50.00	Single	6D32	Cyclopamine	6D32-SMO-Cyclopamine-Cyclopamine
50.00	Consensus	p2y1_off	Orthosteric Ligand	4XNW-P2Y₁-MRS2500
46.15	Single	4QIM	ANTA XV	4QIM-SMO-ANTA XV
45.45	Single	5L7I	Vismodegib	5L7I-SMO-Vismodegib
42.86	Single	4JKV	Taladegib	4JKV-SMO-Taladegib
42.86	Single	8TH4	AT118-L Nanobody	8TH4-AT₁-Losartan-AT118-L Nanobody
41.67	Consensus	cxcr1_on	Orthosteric Ligand	8IC0-CXCR1-Interleukin-8-Gi1/β1/γ2
40.00	Single	5V56	TC114	5V56-SMO-TC114
40.00	Single	5V57	TC114	5V57-SMO-TC114
40.00	Single	6XBM	25(S)-Epoxycholesterol	6XBM-SMO-25(S)-Epoxycholesterol-Gi1/β1/γ2
40.00	Consensus	p2y_off	Orthosteric Ligand	p2y1_off
36.36	Single	8JPS	CCL7	8JPS-ACKR1-CCL7
35.71	Single	5T04	Neurotensin	5T04-NTS₁-Neurotensin
35.71	Single	6Z4V	NTS8-13	6Z4V-NTS₁-NTS8-13
35.71	Single	7SK8	CXCL12	7SK8-ACKR3-CXCL12-CCX662
35.71	Single	8IC0	Interleukin-8	8IC0-CXCR1-Interleukin-8-Gi1/β1/γ2
35.71	Consensus	cxcr1_on_gp	Orthosteric Ligand	8IC0-CXCR1-Interleukin-8-Gi1/β1/γ2
35.29	Single	8K4O	CXCL1	8K4O-KSHV-CXCL1-Gi1/β1/γ1
35.29	Single	8XWF	CXCL3	8XWF-CXCR2-CXCL3
33.33	Single	8XX6	CXCL8	8XX6-CXCR2-CXCL8-Go/β1/γ2
33.33	Single	9EAH	Nanobody AT209	9EAH-AT₁-Olmesartan-Nanobody AT209
31.58	Single	7NA7	Ghrelin-27	7NA7-Ghrelin-Ghrelin-27-Gi1/β1/γ2
31.58	Single	8XWN	CXCL8	8XWN-CXCR2-CXCL8
31.25	Single	3ZEV	Neurotensin	3ZEV-NTS₁-Neurotensin
31.25	Single	4BV0	Neurotensin	4BV0-NTS₁-Neurotensin
31.25	Single	6OS1	TRV026	6OS1-AT₁-TRV026
31.25	Single	7L0P	Neurotensin	7L0P-NTS₁-Neurotensin-Gi1/β1/γ1
31.25	Single	7L0Q	Neurotensin	7L0Q-NTS₁-Neurotensin-Gi1/β1/γ1
31.25	Single	7SK7	CXCL12	7SK7-ACKR3-CXCL12-CCX662
31.25	Single	8HQC	C5a anaphylatoxin	8HQC-C5a₁-C5a anaphylatoxin-Go/β1/γ2
31.25	Single	8WJX	ADP	8WJX-P2Y₁-ADP-chim(Gs-CtGq)/β1/γ2
31.25	Single	8XX7	CXCL5	8XX7-CXCR2-CXCL5-Go/β1/γ2
31.25	Consensus	neurotensin_on	Orthosteric Ligand	nts1_on
31.25	Consensus	nts1_on	Orthosteric Ligand	6OSA-NTS₁-JMV449-Gi1/β1/γ2 7L0S-NTS₁-Neurotensin-Gi1/β1/γ1
30.77	Single	4BWB	Neurotensin	4BWB-NTS₁-Neurotensin
30.77	Single	6LFO	Interleukin-8	6LFO-CXCR2-Interleukin-8-Gi1/β1/γ2
30.77	Single	8XXX	CXCL6	8XXX-CXCR2-CXCL6-Go/β1/γ2
30.00	Single	7C6A	(Sar1,Ile8)-Angiotensin II	7C6A-AT₂-(Sar1,Ile8)-Angiotensin II
30.00	Consensus	gi_ghrelin	Orthosteric Ligand	7NA7-Ghrelin-Ghrelin-27-Gi1/β1/γ2 7NA8-Ghrelin-PubChem 178024-Gi1/β1/γ2
29.41	Single	4GRV	Neurotensin-(8-13)	4GRV-NTS₁-Neurotensin-(8-13)
29.41	Single	4XEE	Neurotensin	4XEE-NTS₁-Neurotensin
29.41	Single	4XES	Neurotensin	4XES-NTS₁-Neurotensin
29.41	Single	6OS2	TRV026	6OS2-AT₁-TRV026
29.41	Single	6OSA	JMV449	6OSA-NTS₁-JMV449-Gi1/β1/γ2
29.41	Single	6YVR	NTS8-13	6YVR-NTS₁-NTS8-13
29.41	Single	8J6D	EP141	8J6D-C3a_B-EP141-Go/β1/γ2
29.41	Single	8JPB	Neurotensin-(8-13)	8JPB-NTS₁-Neurotensin-(8-13)-PubChem 118610427; GDP; Mg-Gq; GRK2
29.41	Single	8JPC	Neurotensin-(8-13)	8JPC-NTS₁-Neurotensin-(8-13)-PubChem 118610427; GDP; Mg-Gq; GRK2
29.41	Single	8XWA	CXCL1	8XWA-CXCR2-CXCL1
29.41	Single	8XWM	CXCL6	8XWM-CXCR2-CXCL6
29.41	Single	8XWS	CXCL5	8XWS-CXCR2-CXCL5
29.41	Single	8XX3	CXCL3	8XX3-CXCR2-CXCL3-Go/β1/γ2
29.41	Consensus	cxcr_on	Orthosteric Ligand	cxcr3_on cxcr4_on cxcr1_on cxcr2_on
29.41	Consensus	gi_neurotensin	Orthosteric Ligand	6OSA-NTS₁-JMV449-Gi1/β1/γ2 7L0S-NTS₁-Neurotensin-Gi1/β1/γ1
29.41	Consensus	neurotensin_on_gp	Orthosteric Ligand	nts1_on_gp
29.41	Consensus	nts1_on_gp	Orthosteric Ligand	6OSA-NTS₁-JMV449-Gi1/β1/γ2 7L0S-NTS₁-Neurotensin-Gi1/β1/γ1
28.57	Single	6U1N	LY2119620	6U1N-M₂-LY2119620-Arrestin2
28.57	Single	7T94	PubChem 57664406	7T94-M₂-Acetylcholine-PubChem 57664406-chim(NtGi1-Go)/β1/γ2
28.57	Single	7UTZ	PubChem 644078	7UTZ-TSH-TR1402-PubChem 644078-Gs/β1/γ2
28.57	Consensus	nucleotide_off	Orthosteric Ligand	adenosine_off p2y_off
28.00	Single	8IY5	Endothelin-1	8IY5-ET_B-Endothelin-1-Gi1/β1/γ2
28.00	Single	8IY6	Endothelin-1	8IY6-ET_B-Endothelin-1
28.00	Consensus	endothelin_on	Orthosteric Ligand	etb_on eta_on
27.78	Single	4BUO	Neurotensin	4BUO-NTS₁-Neurotensin
27.78	Single	4RWS	vMIP-II	4RWS-CXCR4-vMIP-II
27.78	Single	6UP7	Neurotensin	6UP7-NTS₁-Neurotensin-Arrestin2
27.78	Single	8FN0	Neurotensin/Neuromedin-N	8FN0-NTS₁-Neurotensin/Neuromedin-N-PubChem 118610427-chim(NtGi1-Go)/β1/γ2
27.78	Single	8JPF	Neurotensin	8JPF-NTS₁-Neurotensin-PubChem 118610427
27.78	Single	8XVU	CXCL2	8XVU-CXCR2-CXCL2
27.78	Single	8XWV	CXCL1	8XWV-CXCR2-CXCL1-Go/β1/γ2
27.78	Single	8XXH	CXCL2	8XXH-CXCR2-CXCL2-Go/β1/γ2
27.27	Consensus	protein_offon	Orthosteric Ligand	protein_off protein_on
27.27	Consensus	protein_offon_gp	Orthosteric Ligand	protein_on_gp protein_off
26.92	Single	5GLH	Endothelin-1	5GLH-ET_B-Endothelin-1
26.67	Single	6XBM	25(S)-Epoxycholesterol	6XBM-SMO-25(S)-Epoxycholesterol-Gi1/β1/γ2
26.67	Single	7CFM	P395	7CFM-GPBA-P395-Gs/β1/γ2
26.67	Single	7FIH	Org43553	7FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/β1/γ2
26.67	Single	7YU4	ONO-0740556	7YU4-LPA₁-ONO-0740556
26.67	Single	8TH3	AT118-H Nanobody	8TH3-AT₁-AT118-H Nanobody
26.67	Single	9IMA	Talquetamab	9IMA-GPRC5D-Talquetamab
26.67	Consensus	nucleotide_offon	Orthosteric Ligand	nucleotide_off nucleotide_on
26.67	Consensus	nucleotide_offon_gp	Orthosteric Ligand	nucleotide_on_gp nucleotide_off
26.32	Single	5VBL	Apelin mimetic peptide agonist	5VBL-Apelin-Apelin mimetic peptide agonist
26.32	Single	6KNM	JN241-9	6KNM-Apelin-JN241-9
26.32	Single	6OS9	JMV449	6OS9-NTS₁-JMV449-Gi1/β1/γ2
26.32	Single	8XQJ	JN241	8XQJ-Apelin-JN241
26.32	Single	9EAJ	Nanobody AT209	9EAJ-AT₁-Nanobody AT209
26.32	Consensus	cxcr_on_gp	Orthosteric Ligand	cxcr3_on_gp cxcr4_on_gp cxcr1_on_gp cxcr2_on_gp
26.09	Single	7F6H	Bradykinin	7F6H-BK₂-Bradykinin-Gq/β1/γ2
26.09	Single	7F6I	Kallidin	7F6I-BK₂-Kallidin-Gq/β1/γ2
26.09	Single	8HCX	Endothelin-1	8HCX-ET_B-Endothelin-1-chim(NtGi2L-Gs-CtGq)/β1/γ2
26.09	Single	8XVI	Endothelin-1	8XVI-ET_A-Endothelin-1-chim(Gs-CtGq)/β1/γ2
26.09	Consensus	chemokine_on_gp	Orthosteric Ligand	ccr_on_gp cxcr_on_gp
25.93	Single	7SK6	CXCL12_LRHQ	7SK6-ACKR3-CXCL12_LRHQ
25.93	Consensus	endothelin_on_gp	Orthosteric Ligand	etb_on_gp eta_on_gp
25.00	Single	5N2R	PSB-36	5N2R-A_2A-PSB-36-Na
25.00	Single	6LFM	Interleukin-8	6LFM-CXCR2-Interleukin-8-Gi1/β1/γ2
25.00	Single	6LRY	Sarafotoxin-B	6LRY-ET_B-Sarafotoxin-B
25.00	Single	6PWC	Neurotensin	6PWC-NTS₁-Neurotensin-Arrestin2
25.00	Single	6XBK	Cholesterol	6XBK-SMO-Cholesterol-Gi1/β1/γ2
25.00	Single	7L0R	Neurotensin	7L0R-NTS₁-Neurotensin-Gi1/β1/γ1
25.00	Single	7SK3	CXCL12	7SK3-ACKR3-CXCL12
25.00	Single	7SK4	CXCL12_LRHQ	7SK4-ACKR3-CXCL12_LRHQ
25.00	Single	7W0P	Elabela	7W0P-Apelin-Elabela-Gi1/β1/γ2
25.00	Single	7W2Z	Ghrelin	7W2Z-Ghrelin-Ghrelin-Go/β1/γ2
25.00	Single	7YU3	ONO-0740556	7YU3-LPA₁-ONO-0740556-Gi1/β1/γ2
25.00	Single	7YU6	ONO-0740556	7YU6-LPA₁-ONO-0740556-Gi1/β1/γ2
25.00	Single	8JEF	(3S)-3-hydroxyoctanoic acid	8JEF-HCA₃-(3S)-3-hydroxyoctanoic acid-Gi1/β1/γ2
25.00	Single	8K3Z	CXCL12	8K3Z-CXCR4-CXCL12-Gi1/β1/γ1
25.00	Single	8ZPT	PrRP20	8ZPT-PrRP-PrRP20-chim(NtGi1-Gs-CtGq)/β1/γ2
25.00	Single	9L3Y	Retinoic acid receptor responder protein 2	9L3Y-CML2-Retinoic acid receptor responder protein 2-Gi1/β1/γ2
25.00	Consensus	chemokine_on	Orthosteric Ligand	ccr_on cxcr_on
25.00	Consensus	cxcr2_on_gp	Orthosteric Ligand	6LFM-CXCR2-Interleukin-8-Gi1/β1/γ2
25.00	Consensus	cxcr4_on	Orthosteric Ligand	8K3Z-CXCR4-CXCL12-Gi1/β1/γ1
25.00	Consensus	gi_peptide	Orthosteric Ligand	gi_cck gi_apelin gi_compl-pept gi_endothelin gi_formylpeptide gi_galanin gi_ghrelin gi_npy gi_neurotensin gi_opioid gi_orexin gi_relaxin gi_somatostatin
23.81	Single	5XJM	(Sar1,Ile8)-Angiotensin II	5XJM-AT₂-(Sar1,Ile8)-Angiotensin II
23.81	Single	6DO1	Angiotensin-like peptide S1I8	6DO1-AT₁-Angiotensin-like peptide S1I8
23.81	Single	7F1Q	MIP-1a	7F1Q-CCR5-MIP-1a-Gi1/β1/γ2
23.81	Single	7SK5	CXCL12	7SK5-ACKR3-CXCL12
23.81	Single	8IBV	Motilin	8IBV-Motilin-Motilin-chim(NtGi1-Gs-CtGq)/β1/γ2
23.81	Single	8JZZ	C5a-desArg	8JZZ-C5a₁-C5a-desArg-Go/β1/γ2
23.81	Single	8Z7J	Agonistic antibody	8Z7J-Apelin-Agonistic antibody-Gi1/β1/γ2
23.81	Consensus	compl-peptide_on	Orthosteric Ligand	c5a1_on c3a_on
23.53	Single	7T9N	PubChem 644078	7T9N-TSH-M22 Fab-PubChem 644078-Gs/β1/γ2
23.53	Single	7XTQ	R399	7XTQ-GPBA-R399-Gs/β1/γ2
23.53	Single	7YU5	ONO-0740556	7YU5-LPA₁-ONO-0740556-Gi1/β1/γ2
23.53	Single	7YU7	ONO-0740556	7YU7-LPA₁-ONO-0740556-Gi1/β1/γ2
23.53	Single	8FMZ	Neurotensin/Neuromedin-N	8FMZ-NTS₁-Neurotensin/Neuromedin-N-chim(NtGi2L-Gs-CtGq)/β1/γ2
23.53	Single	8FN1	Neurotensin/Neuromedin-N	8FN1-NTS₁-Neurotensin/Neuromedin-N-chim(NtGi1-Go)/β1/γ2
23.53	Single	9IZG	NKP	9IZG-LPA₁-NKP-chim(NtGi1-Gs-CtGq)/β1/γ2
23.53	Consensus	gi_lpa	Orthosteric Ligand	7TD1-LPA₁-LPA-Gi1/β1/γ2 7YU3-LPA₁-ONO-0740556-Gi1/β1/γ2
23.53	Consensus	lpa_on	Orthosteric Ligand	lpa1_on
23.53	Consensus	lpa_on_gp	Orthosteric Ligand	lpa1_on_gp
23.08	Single	6IGL	IRL1620	6IGL-ET_B-IRL1620
23.08	Single	6LI0	C17	6LI0-GPR52-C17
23.08	Single	7T96	LY2119620	7T96-M₂-Acetylcholine-LY2119620-Go/β1/γ2
23.08	Single	7VDH	C48/80	7VDH-MRGPRX2-C48/80-Gi1/β1/γ2
23.08	Single	8ZX5	AM251	8ZX5-GPR55-AM251-chim(NtGi1-G13)/β1/γ2
23.08	Consensus	bk2_on	Orthosteric Ligand	7F6H-BK₂-Bradykinin-Gq/β1/γ2 7F6I-BK₂-Kallidin-Gq/β1/γ2
23.08	Consensus	bk2_on_gp	Orthosteric Ligand	7F6H-BK₂-Bradykinin-Gq/β1/γ2 7F6I-BK₂-Kallidin-Gq/β1/γ2
23.08	Consensus	bradykinin_on	Orthosteric Ligand	bk2_on
23.08	Consensus	bradykinin_on_gp	Orthosteric Ligand	bk2_on_gp
23.08	Consensus	etb_on	Orthosteric Ligand	8IY5-ET_B-Endothelin-1-Gi1/β1/γ2 8HBD-ET_B-IRL1620-Gi1/β1/γ2
23.08	Consensus	gq_bradykinin	Orthosteric Ligand	7F6H-BK₂-Bradykinin-Gq/β1/γ2 7F6I-BK₂-Kallidin-Gq/β1/γ2
22.73	Single	3OE0	CVX15	3OE0-CXCR4-CVX15
22.73	Single	6LW5	WKYMVm	6LW5-FPR2-ALX-WKYMVm
22.73	Consensus	angiotensin_on	Orthosteric Ligand	at1_on
22.73	Consensus	at1_on	Orthosteric Ligand	7F6G-AT₁-SAR1-AngII-Gq/β1/γ2
22.73	Consensus	compl-peptide_on_gp	Orthosteric Ligand	c5a1_on_gp c3a_on_gp
22.73	Consensus	cxcr4_on_gp	Orthosteric Ligand	8K3Z-CXCR4-CXCL12-Gi1/β1/γ1
22.22	Single	6IGK	Endothelin-3	6IGK-ET_B-Endothelin-3
22.22	Single	6OS0	Angiotensinogen	6OS0-AT₁-Angiotensinogen
22.22	Single	7L0S	Neurotensin	7L0S-NTS₁-Neurotensin-Gi1/β1/γ1
22.22	Single	7XJK	Galanin	7XJK-GAL₂-Galanin-chim(NtGi2L-Gs-CtGq)/β1/γ2
22.22	Single	7XW5	ML109	7XW5-TSH-TSH-ML109-Gs/β1/γ2
22.22	Single	8XQJ	JN241	8XQJ-Apelin-JN241
22.22	Single	8ZPL	HF51116	8ZPL-CXCR4-HF51116-Cholesterol
22.22	Consensus	gi_endothelin	Orthosteric Ligand	8IY5-ET_B-Endothelin-1-Gi1/β1/γ2 8HBD-ET_B-IRL1620-Gi1/β1/γ2
22.22	Consensus	lpa1_off	Orthosteric Ligand	4Z36-LPA₁-ONO-3080573 4Z35-LPA₁-ONO-9910539 4Z34-LPA₁-ONO-9780307
22.22	Consensus	lpa_off	Orthosteric Ligand	lpa1_off
22.22	Consensus	lpl_off	Orthosteric Ligand	s1p_off lpa_off
21.74	Single	6JOD	Angiotensin II	6JOD-AT₂-Angiotensin II
21.74	Single	7F6G	SAR1-AngII	7F6G-AT₁-SAR1-AngII-Gq/β1/γ2
21.74	Single	8XZJ	WN353	8XZJ-Apelin-WN353-Gi1/β1/γ2
21.74	Consensus	angiotensin_on_gp	Orthosteric Ligand	at1_on_gp
21.74	Consensus	at1_on_gp	Orthosteric Ligand	7F6G-AT₁-SAR1-AngII-Gq/β1/γ2
21.74	Consensus	gi_class-a	Orthosteric Ligand	gi_peptide gi_sensory gi_alicarboxylic gi_amine gi_lipid gi_nucleotide gi_protein
21.74	Consensus	gq_angiotensin	Orthosteric Ligand	7F6G-AT₁-SAR1-AngII-Gq/β1/γ2
21.74	Consensus	protein_on	Orthosteric Ligand	chemokine_on chemerin_on
21.43	Single	3VG9	ZM-241385	3VG9-A_2A-ZM-241385-Antibody
21.43	Single	4MQT	LY2119620	4MQT-M₂-Iperoxo-LY2119620
21.43	Single	5OLO	Tozadenant	5OLO-A_2A-Tozadenant-Na
21.43	Single	6WWZ	CCL20	6WWZ-CCR6-CCL20-Go/β1/γ2
21.43	Single	7VV5	C48/80	7VV5-MRGPRX2-C48/80-Gi1/β1/γ2
21.43	Single	7W0O	Elabela	7W0O-Apelin-Elabela-Gi1/β1/γ2
21.43	Single	8H8J	Lodoxamide	8H8J-GPR35-Lodoxamide-Ca-chim(NtGi1L-G13)/β1/γ2
21.43	Single	8HBD	IRL1620	8HBD-ET_B-IRL1620-Gi1/β1/γ2
21.43	Single	8HMP	C17	8HMP-GPR52-C17-Gs/β1/γ2
21.43	Single	8IJA	Niacin	8IJA-HCA₂-Niacin-Gi1/β1/γ2
21.43	Single	9BA0	A1AKN	9BA0-CB₁-A1AKN
21.43	Consensus	ccr6_on	Orthosteric Ligand	6WWZ-CCR6-CCL20-Go/β1/γ2
21.43	Consensus	ccr6_on_gp	Orthosteric Ligand	6WWZ-CCR6-CCL20-Go/β1/γ2
21.43	Consensus	etb_on_gp	Orthosteric Ligand	8IY5-ET_B-Endothelin-1-Gi1/β1/γ2 8HBD-ET_B-IRL1620-Gi1/β1/γ2
21.43	Consensus	p2y1_on	Orthosteric Ligand	7XXH-P2Y₁-2MeSADP-chim(NtGi1-G11)/β1/γ2
21.05	Single	4Z35	ONO-9910539	4Z35-LPA₁-ONO-9910539
21.05	Single	7EZC	UKA	7EZC-A_2A-UKA
21.05	Single	7YU8	ONO-0740556	7YU8-LPA₁-ONO-0740556-Gi1/β1/γ2
21.05	Single	8ZX4	Lysophosphatidylinositol	8ZX4-GPR55-Lysophosphatidylinositol-chim(NtGi1-G13)/β1/γ2
21.05	Single	9GE3	Lysophosphatidylinositol	9GE3-GPR55-Lysophosphatidylinositol-chim(CtGi1-G13)/β1/γ2
20.83	Single	7Y64	C5a anaphylatoxin	7Y64-C5a₁-C5a anaphylatoxin-Gi1/β1/γ2
20.83	Single	8HCQ	Endothelin-1	8HCQ-ET_A-Endothelin-1-chim(NtGi1-Gs-CtGq)/β1/γ2
20.83	Single	8XVH	Endothelin-1	8XVH-ET_B-Endothelin-1-chim(Gs-CtGq)/β1/γ2
20.83	Single	8ZRT	ET-1	8ZRT-ET_B-ET-1
20.83	Consensus	cxcr_off	Orthosteric Ligand	cxcr3_off cxcr4_off
20.83	Consensus	eta_on	Orthosteric Ligand	8HCQ-ET_A-Endothelin-1-chim(NtGi1-Gs-CtGq)/β1/γ2
20.83	Consensus	eta_on_gp	Orthosteric Ligand	8HCQ-ET_A-Endothelin-1-chim(NtGi1-Gs-CtGq)/β1/γ2
20.83	Consensus	gi_chemokine	Orthosteric Ligand	6WWZ-CCR6-CCL20-Go/β1/γ2 8HNK-CXCR3-CXCL11-Gi1/β1/γ2 8K3Z-CXCR4-CXCL12-Gi1/β1/γ1 8IC0-CXCR1-Interleukin-8-Gi1/β1/γ2 6LFM-CXCR2-Interleukin-8-Gi1/β1/γ2 8KFX-CCR8-LMD-009-Gi1/β1/γ2 7F1Q-CCR5-MIP-1a-Gi1/β1/γ2 8HNL-CXCR3-PS372424-Gi1/β1/γ2 8KFY-CCR8-ZK-756326-Gi1/β1/γ2 7O7F-CCR5-6P4-CCL5-Gi1/β1/γ1 8U1U-CCR8-CCL1-Gi1/β1/γ2 7VLA-CCR1-CCL15(27-92)-Gi1/β1/γ2 7XA3-CCR2-CCL2-Gi1/β1/γ2
20.00	Single	5IU4	ZM-241385	5IU4-A_2A-ZM-241385-Na
20.00	Single	5IUB	Q27456344	5IUB-A_2A-Q27456344-Na
20.00	Single	5K2C	ZM-241385	5K2C-A_2A-ZM-241385-Na
20.00	Single	5NM4	ZM-241385	5NM4-A_2A-ZM-241385-Na
20.00	Single	5WF6	UK-432097	5WF6-A_2A-UK-432097
20.00	Single	7C2E	PubChem 149050799	7C2E-GLP-1-PubChem 149050799-Gs/β1/γ2
20.00	Single	7F2O	Bradykinin	7F2O-BK₂-Bradykinin-chim(NtGi1-Gs-CtGq)/β1/γ2
20.00	Single	7T32	ZM-241385	7T32-A_2A-ZM-241385
20.00	Single	7VV6	C48/80	7VV6-MRGPRX2-C48/80
20.00	Single	7XXH	2MeSADP	7XXH-P2Y₁-2MeSADP-chim(NtGi1-G11)/β1/γ2
20.00	Single	8QJ2	pN162	8QJ2-MC₄-pN162-Gs
20.00	Single	8XQF	Apelin-13	8XQF-Apelin-Apelin-13-Gi1/β1/γ2
20.00	Single	8XZF	WN561	8XZF-Apelin-WN561-Gi1/β1/γ2
20.00	Consensus	ccr5_on	Orthosteric Ligand	7O7F-CCR5-6P4-CCL5-Gi1/β1/γ1 7F1Q-CCR5-MIP-1a-Gi1/β1/γ2
20.00	Consensus	cxcr2_on	Orthosteric Ligand	6LFM-CXCR2-Interleukin-8-Gi1/β1/γ2
20.00	Consensus	cxcr4_off	Orthosteric Ligand	4RWS-CXCR4-vMIP-II 3OE0-CXCR4-CVX15 3OE6-CXCR4-IT1t
20.00	Consensus	formylpeptide_on	Orthosteric Ligand	fpr2-alx_on fpr1-alx_on
20.00	Consensus	gi_compl-pept	Orthosteric Ligand	8HK5-C5a₁-Complement C5-Gi1/β1/γ2 8IA8-C3a_B-E7 peptide-Gi1/β1/γ2 7Y66-C5a₁-BM213-Gi1/β1/γ2 7Y67-C5a₁-C089 peptide-Gi1/β1/γ2 8HK2-C3a_B-C3a anaphylatoxin-Gi1/β1/γ2 7Y64-C5a₁-C5a anaphylatoxin-Gi1/β1/γ2
20.00	Consensus	gi_protein	Orthosteric Ligand	gi_chemokine gi_chemerin
20.00	Consensus	grh_off	Orthosteric Ligand	gnrh1_off
20.00	Consensus	p2y1_on_gp	Orthosteric Ligand	7XXH-P2Y₁-2MeSADP-chim(NtGi1-G11)/β1/γ2
20.00	Consensus	protein_on_gp	Orthosteric Ligand	chemokine_on_gp chemerin_on_gp
19.23	Consensus	gq_peptide	Orthosteric Ligand	gq_cck gq_kisspeptin gq_bradykinin gq_bombesin gq_angiotensin
19.23	Consensus	peptide_on	Orthosteric Ligand	cck_on angiotensin_on apelin_on bombesin_on bradykinin_on compl-peptide_on endothelin_on formylpeptide_on galanin_on ghrelin_on kisspeptin_on melanocortin_on motilin_on neuromedin-u_on npy_on neurotensin_on opioid_on orexin_on relaxin_on somatostatin_on tachykinin_on trh_on vasop-oxy_on
19.23	Consensus	peptide_on_gp	Orthosteric Ligand	cck_on_gp angiotensin_on_gp apelin_on_gp bombesin_on_gp bradykinin_on_gp compl-peptide_on_gp endothelin_on_gp formylpeptide_on_gp galanin_on_gp ghrelin_on_gp kisspeptin_on_gp melanocortin_on_gp motilin_on_gp neuromedin-u_on_gp npy_on_gp neurotensin_on_gp opioid_on_gp orexin_on_gp relaxin_on_gp somatostatin_on_gp tachykinin_on_gp trh_on_gp vasop-oxy_on_gp
19.05	Single	7F54	Afamelanotide	7F54-MC₄-Afamelanotide-Gs/β1/γ2
19.05	Single	7VLA	CCL15(27-92)	7VLA-CCR1-CCL15(27-92)-Gi1/β1/γ2
19.05	Single	8U4O	CXCL12	8U4O-CXCR4-CXCL12-Cholesterol-Gi1/β1/γ2
19.05	Single	8XGM	Chemerin	8XGM-CML2-Chemerin-Gi1/β1/γ2
19.05	Consensus	ccr1_on	Orthosteric Ligand	7VLA-CCR1-CCL15(27-92)-Gi1/β1/γ2
19.05	Consensus	ccr1_on_gp	Orthosteric Ligand	7VLA-CCR1-CCL15(27-92)-Gi1/β1/γ2
19.05	Consensus	lpl_on	Orthosteric Ligand	s1p_on lpa_on
19.05	Consensus	lpl_on_gp	Orthosteric Ligand	s1p_on_gp lpa_on_gp
19.05	Consensus	p2y_on	Orthosteric Ligand	p2y1_on p2y10_on p2y12_on
18.75	Single	4EIY	ZM-241385	4EIY-A_2A-ZM-241385-Na
18.75	Single	5IU8	Q27456347	5IU8-A_2A-Q27456347-Na
18.75	Single	5OLG	ZM-241385	5OLG-A_2A-ZM-241385-Na
18.75	Single	6LPJ	ZM-241385	6LPJ-A_2A-ZM-241385-Na
18.75	Single	6LPK	ZM-241385	6LPK-A_2A-ZM-241385-Na
18.75	Single	6X1A	Danuglipron	6X1A-GLP-1-Danuglipron-Gs/β1/γ2
18.75	Single	7LCK	Danuglipron	7LCK-GLP-1-Danuglipron
18.75	Single	7PYR	PSB-2115	7PYR-A_2A-PSB-2115
18.75	Single	7S15	PubChem 134611223	7S15-GLP-1-PubChem 134611223
18.75	Single	7TRQ	VU0467154	7TRQ-M₄-Iperoxo-VU0467154-Gi1/β1/γ2
18.75	Single	7WQ3	Galanin	7WQ3-GAL₁-Galanin-Gi1/β1/γ2
18.75	Single	8I7V	Acipimox	8I7V-HCA₂-Acipimox-Gi1/β1/γ2
18.75	Single	8JHN	MMF	8JHN-HCA₂-MMF-Go/β1/γ2
18.75	Single	9B9Z	A1AKO	9B9Z-CB₁-A1AKO
18.75	Consensus	gal1_on	Orthosteric Ligand	7WQ3-GAL₁-Galanin-Gi1/β1/γ2
18.75	Consensus	gal1_on_gp	Orthosteric Ligand	7WQ3-GAL₁-Galanin-Gi1/β1/γ2
18.75	Consensus	gi_galanin	Orthosteric Ligand	7WQ3-GAL₁-Galanin-Gi1/β1/γ2
18.52	Consensus	gs_melanocortin	Orthosteric Ligand	7F4H-MC₁-Afamelanotide-chim(NtGi1-Gs)/β1/γ2 7F54-MC₄-Afamelanotide-Gs/β1/γ2 7F4D-MC₁-α-MSH-chim(NtGi1-Gs)/β1/γ2 8INR-MC₅-α-MSH-Ca-chim(NtGi1-Gs)/β1/γ2 7F53-MC₄-α-MSH-Gs/β1/γ2 7F55-MC₄-Bremelanotide-Gs/β1/γ2 8GY7-MC₂-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1 8IOC-MC₃-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2 8IOD-MC₅-PG-901-Ca-chim(NtGi1-Gs)/β1/γ2 7AUE-MC₄-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2 7F4I-MC₁-SHU9119-chim(NtGi1-Gs)/β1/γ2 7F58-MC₄-THIQ-Gs/β1/γ2
18.18	Single	3QAK	UK-432097	3QAK-A_2A-UK-432097
18.18	Single	7VBI	Non-Acylated Tirzepatide	7VBI-GLP-1-Non-Acylated Tirzepatide-Gs/β1/γ2
18.18	Single	7W0N	Elabela	7W0N-Apelin-Elabela-Gi1/β1/γ2
18.18	Single	7XMS	Somatostatin-14	7XMS-SST4-Somatostatin-14-Gi1/β1/γ2
18.18	Single	7XNA	CYN154806	7XNA-SST2-CYN154806
18.18	Single	8HQM	NPGLY	8HQM-GPR132-NPGLY-Gi1/β1/γ2
18.18	Single	8HS2	Fab046	8HS2-GPR20-Fab046
18.18	Single	8HVI	NOX-6-7	8HVI-GPR132-NOX-6-7-Gi1/β1/γ2
18.18	Single	8WSS	Pro-MCH	8WSS-MCH1-Pro-MCH-Gi1/β1/γ1
18.18	Consensus	formylpeptide_on_gp	Orthosteric Ligand	fpr2-alx_on_gp fpr1-alx_on_gp
18.18	Consensus	gq_class-a	Orthosteric Ligand	gq_peptide gq_amine gq_nucleotide
18.18	Consensus	sst2_off	Orthosteric Ligand	7XNA-SST2-CYN154806
17.86	Single	8U1U	CCL1	8U1U-CCR8-CCL1-Gi1/β1/γ2
17.86	Consensus	ccr5_on_gp	Orthosteric Ligand	7O7F-CCR5-6P4-CCL5-Gi1/β1/γ1 7F1Q-CCR5-MIP-1a-Gi1/β1/γ2
17.65	Single	5IUA	Q27456348	5IUA-A_2A-Q27456348-Na
17.65	Single	5N2S	PSB36	5N2S-A₁-PSB36
17.65	Single	5NM2	ZM-241385	5NM2-A_2A-ZM-241385-Na
17.65	Single	6LPL	ZM-241385	6LPL-A_2A-ZM-241385-Na
17.65	Single	6S0Q	ZM-241385	6S0Q-A_2A-ZM-241385
17.65	Single	6WQA	ZM-241385	6WQA-A_2A-ZM-241385-Na
17.65	Single	7RM5	ZM-241385	7RM5-A_2A-ZM-241385-Na
17.65	Single	8FYN	ZM-241385	8FYN-A_2A-ZM-241385-Na
17.65	Single	8GNE	KW-6356	8GNE-A_2A-KW-6356-Na
17.65	Single	8QOT	Nanobody-E	8QOT-μ-Nanobody-E
17.65	Single	8UUJ	FCH-2296413	8UUJ-HCA₂-FCH-2296413-Gi1/β1/γ2
17.65	Consensus	a1_off	Orthosteric Ligand	5UEN-A₁-DU172 5N2S-A₁-PSB36
17.65	Consensus	adenosine_off	Orthosteric Ligand	a1_off a2_off
17.65	Consensus	lpa1_on	Orthosteric Ligand	7TD1-LPA₁-LPA-Gi1/β1/γ2 7YU3-LPA₁-ONO-0740556-Gi1/β1/γ2
17.65	Consensus	lpa1_on_gp	Orthosteric Ligand	7TD1-LPA₁-LPA-Gi1/β1/γ2 7YU3-LPA₁-ONO-0740556-Gi1/β1/γ2
17.65	Consensus	s1p5_off	Orthosteric Ligand	7YXA-S1P₅-ONO-5430608
17.65	Consensus	s1p_off	Orthosteric Ligand	s1p1_off s1p5_off
17.39	Single	5WF5	UK-432097	5WF5-A_2A-UK-432097
17.39	Single	6MEO	Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4	6MEO-CCR5-Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4
17.39	Single	7TD0	LPA	7TD0-LPA₁-LPA-Gi1/β1/γ2
17.39	Single	7TD2	LPA	7TD2-LPA₁-LPA-Gi1/β1/γ2
17.39	Single	7XA3	CCL2	7XA3-CCR2-CCL2-Gi1/β1/γ2
17.39	Single	8K6N	Pro-neuropeptide-Y	8K6N-Y₂-Pro-neuropeptide-Y-Gi2/β1/γ1
17.39	Single	8XZG	Apelin-13	8XZG-Apelin-Apelin-13-Gi1/β1/γ2
17.39	Single	8XZH	MM07	8XZH-Apelin-MM07-Gi1/β1/γ2
17.39	Single	9IVM	GLP-1 (Truncated)	9IVM-GLP-1-GLP-1 (Truncated)-LSN3318839-chim(NtGi1-Gs)/β2/γ2
17.39	Single	9K27	PrRP31	9K27-PrRP-PrRP31-chim(NtGi1-Gq)/β1/γ2
17.39	Consensus	c5a1_on	Orthosteric Ligand	8HK5-C5a₁-Complement C5-Gi1/β1/γ2 7Y66-C5a₁-BM213-Gi1/β1/γ2 7Y67-C5a₁-C089 peptide-Gi1/β1/γ2 7Y64-C5a₁-C5a anaphylatoxin-Gi1/β1/γ2
17.39	Consensus	ccr2_on	Orthosteric Ligand	7XA3-CCR2-CCL2-Gi1/β1/γ2
17.39	Consensus	ccr2_on_gp	Orthosteric Ligand	7XA3-CCR2-CCL2-Gi1/β1/γ2
17.39	Consensus	ccr_on	Orthosteric Ligand	ccr6_on ccr8_on ccr2_on ccr1_on ccr5_on
17.39	Consensus	peptide_offon	Orthosteric Ligand	peptide_off peptide_on
17.24	Consensus	melanocortin_on	Orthosteric Ligand	mc1_on mc4_on mc2_on mc3_on mc5_on
17.24	Consensus	melanocortin_on_gp	Orthosteric Ligand	mc1_on_gp mc4_on_gp mc2_on_gp mc3_on_gp mc5_on_gp
16.67	Single	4Z34	ONO-9780307	4Z34-LPA₁-ONO-9780307
16.67	Single	5WB2	CX3CL1.35	5WB2-US28-CX3CL1.35
16.67	Single	6MET	Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4	6MET-CCR5-Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4
16.67	Single	6Z8N	SRI-9829	6Z8N-NTS₁-SRI-9829
16.67	Single	7F1T	MIP-1a	7F1T-CCR5-MIP-1a
16.67	Single	7F58	THIQ	7F58-MC₄-THIQ-Gs/β1/γ2
16.67	Single	7KH0	AVP	7KH0-V₂-AVP-chim(NtGi1-Gs)/β1/γ2
16.67	Single	7PX4	PSB-2113	7PX4-A_2A-PSB-2113
16.67	Single	7T10	Somatostatin-14	7T10-SST2-Somatostatin-14-Gi3/β1/γ2
16.67	Single	7TD1	LPA	7TD1-LPA₁-LPA-Gi1/β1/γ2
16.67	Single	7WVX	Humanin	7WVX-FPR2-ALX-Humanin-Gi2/β1/γ2
16.67	Single	7XBD	Galanin	7XBD-GAL₂-Galanin-chim(NtGi2L-Gs-CtGq)/β1/γ2
16.67	Single	7XJL	Spexin	7XJL-GAL₂-Spexin-chim(NtGi2L-Gs-CtGq)/β1/γ2
16.67	Single	7XOW	Gastrin	7XOW-CCK_B-Gastrin-chim(NtGi1-Gq)/β1/γ2
16.67	Single	7YON	Peptide-YY(3-36)	7YON-Y₂-Peptide-YY(3-36)-Gi1/β1/γ2
16.67	Single	8I2G	Compound 716340	8I2G-FSH-Glycoprotein hormones α chain-Compound 716340-Gs/β1/γ2
16.67	Single	8I9L	C3a anaphylatoxin	8I9L-C3a_B-C3a anaphylatoxin-Go/β1/γ2
16.67	Single	8ID3	9-Hydroxystearic acid	8ID3-FFA4-9-Hydroxystearic acid-Gi1/β1/γ2
16.67	Single	8ID6	Oleic acid	8ID6-FFA4-Oleic acid-Gi1/β1/γ2
16.67	Single	8IHB	GSK256073	8IHB-HCA₂-GSK256073-Gi1/β1/γ2
16.67	Single	8IHH	LUF6283	8IHH-HCA₂-LUF6283-Gi1/β1/γ2
16.67	Single	8U4Q	REGN7663-Fab	8U4Q-CXCR4-REGN7663-Fab-Cholesterol-Gi1/β1/γ2
16.67	Single	8X8L	Cortistatin	8X8L-SST5-Cortistatin-chim(NtGi1-Gs-CtGi1)/β1/γ2
16.67	Single	8YW3	Retatrutide	8YW3-GLP-1-Retatrutide-Gs/β1/γ2
16.67	Single	9ITE	LPA	9ITE-LPA₆-LPA-chim(NtGi2-G13)/β1/γ2
16.67	Consensus	c5a1_on_gp	Orthosteric Ligand	8HK5-C5a₁-Complement C5-Gi1/β1/γ2 7Y66-C5a₁-BM213-Gi1/β1/γ2 7Y67-C5a₁-C089 peptide-Gi1/β1/γ2 7Y64-C5a₁-C5a anaphylatoxin-Gi1/β1/γ2
16.67	Consensus	class-a_off	Orthosteric Ligand	sensory_off alicarboxylic_off amine_off lipid_off nucleotide_off peptide_off protein_off
16.67	Consensus	gi_formylpeptide	Orthosteric Ligand	7WVY-FPR2-ALX-Amyloid-β42-Gi2/β1/γ2 7T6U-FPR2-ALX-CGEN-855A-Gi1/β1/γ2 7VFX-FPR1-ALX-fMLF-Gi1/β1/γ2 7T6V-FPR2-ALX-fMLFII-Gi1/β1/γ2 7WVX-FPR2-ALX-Humanin-Gi2/β1/γ2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/β1/γ2 6OMM-FPR2-ALX-WKYMVX-Gi1/β1/γ2
16.67	Consensus	gi_relaxin	Orthosteric Ligand	7YK7-RXFP4-DC591053-Gi2/β1/γ2 7YJ4-RXFP4-INSL5-Gi2/β1/γ2 7YK6-RXFP4-PubChem 138319674-Gi2/β1/γ2
16.67	Consensus	motilin_on	Orthosteric Ligand	8IBU-Motilin-Erythromycin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
16.67	Consensus	p2y_on_gp	Orthosteric Ligand	p2y1_on_gp p2y10_on_gp p2y12_on_gp
16.67	Consensus	peptide_offon_gp	Orthosteric Ligand	peptide_on_gp peptide_off
16.67	Consensus	protein_off	Orthosteric Ligand	chemokine_off grh_off
16.67	Consensus	relaxin_on	Orthosteric Ligand	rxfp4_on
16.67	Consensus	relaxin_on_gp	Orthosteric Ligand	rxfp4_on_gp
16.00	Single	5YQZ	Glucagon analogue	5YQZ-Glucagon-Glucagon analogue
16.00	Single	6X18	GLP-1	6X18-GLP-1-GLP-1-Gs/β1/γ2
16.00	Single	7F9Y	Ghrelin-28	7F9Y-Ghrelin-Ghrelin-28-chim(NtGi1-Gs-CtGq)/β1/γ2
16.00	Single	7TYH	Calcitonin-1	7TYH-CT (AMY2)-Calcitonin-1-Gs/β1/γ2; RAMP2
16.00	Single	7X9B	Neuropeptide-Y	7X9B-Y₂-Neuropeptide-Y-Gi1/β1/γ2
16.00	Single	8E3Y	PACAP27	8E3Y-VPAC₁-PACAP27-Gs/β1/γ2
16.00	Single	8E3Z	VIP	8E3Z-VPAC₁-VIP-Gs/β1/γ2
16.00	Single	8HK5	Complement C5	8HK5-C5a₁-Complement C5-Gi1/β1/γ2
16.00	Single	8HNK	CXCL11	8HNK-CXCR3-CXCL11-Gi1/β1/γ2
16.00	Single	8XQE	Apelin-13	8XQE-Apelin-Apelin-13-Gi1/β1/γ2
16.00	Single	8ZPS	PrRP20	8ZPS-PrRP-PrRP20-chim(NtGi1-Gs-CtGq)/β1/γ2
16.00	Consensus	ccr_on_gp	Orthosteric Ligand	ccr6_on_gp ccr8_on_gp ccr2_on_gp ccr1_on_gp ccr5_on_gp
16.00	Consensus	gi_apelin	Orthosteric Ligand	8XZH-Apelin-MM07-Gi1/β1/γ2 7W0M-Apelin-PubChem 122701908-Gi1/β1/γ2 8XZJ-Apelin-WN353-Gi1/β1/γ2 8XZF-Apelin-WN561-Gi1/β1/γ2 8XZG-Apelin-Apelin-13-Gi1/β1/γ2
16.00	Consensus	opioid_on	Orthosteric Ligand	mop_on nop_on dop_on kop_on
15.79	Single	4PXZ	2MeSADP	4PXZ-P2Y₁₂-2MeSADP
15.79	Single	4PY0	2MeSATP	4PY0-P2Y₁₂-2MeSATP
15.79	Single	4Z36	ONO-3080573	4Z36-LPA₁-ONO-3080573
15.79	Single	7L1U	Orexin	7L1U-OX₂-Orexin-chim(NtGi1-Gs-CtGq)/β1/γ2
15.79	Single	7W0N	Elabela	7W0N-Apelin-Elabela-Gi1/β1/γ2
15.79	Single	7XW6	ML109	7XW6-TSH-M22 Fab-ML109-Gs/β1/γ2
15.79	Single	7Y66	BM213	7Y66-C5a₁-BM213-Gi1/β1/γ2
15.79	Single	8DWC	Proenkephalin-A	8DWC-MRGPRX1-Proenkephalin-A-chim(NtGi2L-Gs-CtGq)/β1/γ2
15.79	Single	8H0Q	Gastrin Releasing Peptide	8H0Q-BB₂-Gastrin Releasing Peptide-chim(NtGi1-Gs-CtGq)/β1/γ2
15.79	Single	8HK2	C3a anaphylatoxin	8HK2-C3a_B-C3a anaphylatoxin-Gi1/β1/γ2
15.79	Single	8I9A	EP54	8I9A-C3a_B-EP54-chim(NtGi1-Gs-CtGq)/β1/γ2
15.79	Single	8IBU	Erythromycin-A	8IBU-Motilin-Erythromycin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
15.79	Single	8JJP	Chemerin	8JJP-CML2-Chemerin-Gi1/β1/γ2
15.79	Single	8T3Q	Docosa-4,7,10,13,16,19-Hexaenoic acid	8T3Q-FFA4-Docosa-4,7,10,13,16,19-Hexaenoic acid-chim(NtGi2L-Gs-CtGq)/β1/γ2
15.79	Single	8U26	Protachykinin-1	8U26-NK₁-Protachykinin-1-Gs/β1/γ2
15.79	Single	9IZH	LPA	9IZH-LPA₁-LPA-chim(NtGi2-G13)/β1/γ2
15.79	Single	9L3W	Retinoic acid receptor responder protein 2	9L3W-CML1-Retinoic acid receptor responder protein 2-Gi1/β1/γ2
15.79	Consensus	galanin_on	Orthosteric Ligand	gal2_on gal1_on
15.79	Consensus	galanin_on_gp	Orthosteric Ligand	gal2_on_gp gal1_on_gp
15.79	Consensus	gi_lipid	Orthosteric Ligand	gi_cannabinoid gi_ffa gi_leukotriene gi_lpa gi_s1p
15.79	Consensus	lipid_offon	Orthosteric Ligand	lipid_off lipid_on
15.79	Consensus	lipid_offon_gp	Orthosteric Ligand	lipid_on_gp lipid_off
15.79	Consensus	motilin_on_gp	Orthosteric Ligand	8IBU-Motilin-Erythromycin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
15.38	Single	4XT3	Fractalkine	4XT3-US28-Fractalkine
15.38	Single	5UIW	5P7-CCL5	5UIW-CCR5-5P7-CCL5
15.38	Single	7KI0	Semaglutide	7KI0-GLP-1-Semaglutide-Gs/β1/γ2
15.38	Single	7RGP	Tirzepatide	7RGP-GLP-1-Tirzepatide-chim(NtGi1-Gs)/β1/γ2
15.38	Single	7V6A	-	7V6A-M₄-PubChem 9864275-Gi1/β1/γ2
15.38	Single	7W3Z	Gastrin Releasing Peptide	7W3Z-BB₂-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/β1/γ2
15.38	Single	8E3X	PACAP27	8E3X-PAC₁-PACAP27-Gs/β1/γ2
15.38	Single	8J6Q	Compound 9n	8J6Q-HCA₂-β-Hydroxybutyrate-Compound 9n-Gi1/β1/γ2
15.38	Single	8JIS	Peptide-15	8JIS-GLP-1-Peptide-15-chim(NtGi1-Gs)/β1/γ2
15.38	Single	8JRV	Glucagon	8JRV-Glucagon-Glucagon-Arrestin2
15.38	Single	8RQL	Flufenamic acid	8RQL-TAS2R14-Flufenamic acid-Flufenamic acid-chim(NtGi1-Gt3)/β1/γ2
15.38	Single	8XVE	BQ3020	8XVE-ET_B-BQ3020-chim(Gs-CtGq)/β1/γ2
15.38	Single	9J1P	g1:Ox	9J1P-GLP-1-g1:Ox-chim(NtGi1-Gs)/β1/γ2
15.38	Consensus	ccr5_off	Orthosteric Ligand	5UIW-CCR5-5P7-CCL5
15.38	Consensus	ccr_off	Orthosteric Ligand	ccr2_off ccr5_off
15.38	Consensus	opioid_on_gp	Orthosteric Ligand	mop_on_gp nop_on_gp dop_on_gp kop_on_gp
15.15	Consensus	mc2_on	Orthosteric Ligand	8GY7-MC₂-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1
15.15	Consensus	mc2_on_gp	Orthosteric Ligand	8GY7-MC₂-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1
15.00	Single	6M1H	Maxadilan	6M1H-PAC₁-Maxadilan-Gs/β1/γ2
15.00	Single	7EW0	Ozanimod	7EW0-S1P₁-Ozanimod-Gi1/β1/γ2
15.00	Single	7EZH	Cholecystokinin-8	7EZH-CCK_A-Cholecystokinin-8-Gi1/β1/γ2
15.00	Single	7EZM	Cholecystokinin-8	7EZM-CCK_A-Cholecystokinin-8-chim(NtGsL-Gq)/β1/γ2
15.00	Single	7LLL	Exendin-4	7LLL-GLP-1-Exendin-4-Gs/β1/γ2
15.00	Single	7P00	Substance-P	7P00-NK₁-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
15.00	Single	7Y65	C5a peptide	7Y65-C5a₁-C5a peptide-Gi1/β1/γ2
15.00	Single	8IYS	TUG-891	8IYS-FFA4-TUG-891-GDP-chim(NtGi1L-Gq)/β1/γ2
15.00	Single	8XBE	S3E-LysoPS	8XBE-GPR34-S3E-LysoPS-Gi1/β1/γ1
15.00	Single	9IZF	NKP	9IZF-LPA₁-NKP-Gi1/β1/γ2
15.00	Consensus	c3a_on_gp	Orthosteric Ligand	8HK2-C3a_B-C3a anaphylatoxin-Gi1/β1/γ2 8IA8-C3a_B-E7 peptide-Gi1/β1/γ2
15.00	Consensus	cck_on	Orthosteric Ligand	ccka_on cckb_on
15.00	Consensus	cck_on_gp	Orthosteric Ligand	ccka_on_gp cckb_on_gp
15.00	Consensus	ccka_on	Orthosteric Ligand	7EZH-CCK_A-Cholecystokinin-8-Gi1/β1/γ2
15.00	Consensus	ccka_on_gp	Orthosteric Ligand	7EZH-CCK_A-Cholecystokinin-8-Gi1/β1/γ2
15.00	Consensus	chemerin_on	Orthosteric Ligand	cml1_on
15.00	Consensus	gal2_on	Orthosteric Ligand	7WQ4-GAL₂-Galanin-chim(NtGi1-Gs-CtGq)/β1/γ2 7XJL-GAL₂-Spexin-chim(NtGi2L-Gs-CtGq)/β1/γ2
15.00	Consensus	gal2_on_gp	Orthosteric Ligand	7WQ4-GAL₂-Galanin-chim(NtGi1-Gs-CtGq)/β1/γ2 7XJL-GAL₂-Spexin-chim(NtGi2L-Gs-CtGq)/β1/γ2
15.00	Consensus	nk1_on	Orthosteric Ligand	7P00-NK₁-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
15.00	Consensus	nk1_on_gp	Orthosteric Ligand	7P00-NK₁-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
14.81	Single	6VCB	GLP-1	6VCB-GLP-1-GLP-1-LSN3160440-Gs/β1/γ2
14.81	Single	7EIB	Des-Arg10-Kallidin	7EIB-BK₁-Des-Arg10-Kallidin-chim(NtGi1-Gs-CtGq)/β1/γ2
14.81	Single	7F53	Alpha-MSH	7F53-MC₄-α-MSH-Gs/β1/γ2
14.81	Single	7S1M	Ex4-D-Ala	7S1M-GLP-1-Ex4-D-Ala-Gs/β1/γ2
14.81	Single	7TYF	Amylin	7TYF-CT (AMY1)-Amylin-Gs/β1/γ2; RAMP1
14.81	Single	7TYN	Calcitonin-1	7TYN-CT-Calcitonin-1-Gs/β1/γ2
14.81	Single	7WVY	Amyloid-Beta42	7WVY-FPR2-ALX-Amyloid-β42-Gi2/β1/γ2
14.81	Single	7XAT	Somatostatin-14	7XAT-SST2-Somatostatin-14-Gi1/β1/γ2
14.81	Single	7YOO	Neuropeptide-Y	7YOO-Y₂-Neuropeptide-Y-Gi1/β1/γ2
14.81	Single	8XWP	Endothelin-1	8XWP-ET_B-Endothelin-1-Gi1/β1/γ2
14.81	Single	8ZJG	Chemerin	8ZJG-CML1-Chemerin-Gi1/β1/γ2
14.81	Single	9K26	PrRP31	9K26-PrRP-PrRP31-Gi1/β1/γ2
14.81	Consensus	npy2_on	Orthosteric Ligand	7YOO-Y₂-Neuropeptide-Y-Gi1/β1/γ2
14.81	Consensus	npy2_on_gp	Orthosteric Ligand	7YOO-Y₂-Neuropeptide-Y-Gi1/β1/γ2
14.29	Single	5VAI	GLP-1	5VAI-GLP-1-GLP-1-Gs/β1/γ2
14.29	Single	6OMM	WKYMVX	6OMM-FPR2-ALX-WKYMVX-Gi1/β1/γ2
14.29	Single	7F8W	Gastrin-17	7F8W-CCK_B-Gastrin-17-chim(NtGsL-Gq)/β1/γ2
14.29	Single	7KI1	Taspoglutide	7KI1-GLP-1-Taspoglutide-Gs/β1/γ2
14.29	Single	7RKF	Fractalkine	7RKF-US28-Fractalkine-GDP-chim(NtGi1-G11)/β1/γ2
14.29	Single	7RKN	Fractalkine	7RKN-US28-Fractalkine-Gi1/β1/γ2
14.29	Single	7RMH	Substance-P	7RMH-NK₁-Substance-P-Gs/β1/γ2
14.29	Single	7TRP	LY2033298	7TRP-M₄-Iperoxo-LY2033298-Gi1/β1/γ2
14.29	Single	7TYL	Amylin	7TYL-CT-Amylin-Gs/β1/γ2
14.29	Single	7UL2	SR48692	7UL2-NTS₁-SR48692-Na
14.29	Single	7VUI	JNJ-63533054	7VUI-GPR139-JNJ-63533054-GTP-chim(Gs-CtGq)/β1/γ2
14.29	Single	7XBX	CX3CL1	7XBX-CX3CR1-CX3CL1-Gi1/β1/γ2
14.29	Single	7YAE	Octreotide	7YAE-SST2-Octreotide-Gi1/β1/γ2
14.29	Single	7YJ4	INSL5	7YJ4-RXFP4-INSL5-Gi2/β1/γ2
14.29	Single	8F0K	Pramlintide Analogue San385	8F0K-CT (AMY3)-Pramlintide Analogue San385-Gs/β1/γ2; RAMP3
14.29	Single	8FX5	Xanomeline	8FX5-M₄-Xanomeline-Xanomeline-Gi1/β1/γ2
14.29	Single	8HSC	Fab046	8HSC-GPR20-Fab046-Gi1/β1/γ2
14.29	Single	8IA7	Cholecystokinin-8	8IA7-CCK_B-Cholecystokinin-8-chim(NtGi1L-Gq)/β1/γ2
14.29	Single	8IHI	Acifran	8IHI-HCA₂-Acifran-Gi1/β1/γ2
14.29	Single	8J6P	Compound 9n	8J6P-HCA₂-Niacin-Compound 9n-Gi1/β1/γ2
14.29	Single	8JBF	Senktide	8JBF-NK₃-Senktide-chim(NtGi1-Gs-CtGq)/β1/γ2
14.29	Single	8JHY	Compound 9n	8JHY-HCA₂-Compound 9n-Gi1/β1/γ2
14.29	Single	8JII	Compound 9n	8JII-HCA₂-Niacin-Compound 9n-Gi1/β1/γ2
14.29	Single	8JIL	Niacin	8JIL-HCA₂-Niacin-Gi1/β1/γ2
14.29	Single	8SAI	1-Oleoyl-2-Hydroxy-Sn-Glycero-3-Phospho-L-Serine	8SAI-GPR34-1-Oleoyl-2-Hydroxy-Sn-Glycero-3-Phospho-L-Serine-Gi1/β1/γ2
14.29	Single	8U4R	REGN7663-Fab	8U4R-CXCR4-REGN7663-Fab-Cholesterol
14.29	Single	8Z74	Agonistic antibody	8Z74-Apelin-Agonistic antibody
14.29	Single	9B9Y	7DY	9B9Y-CB₁-7DY
14.29	Single	9ITB	LPA	9ITB-LPA₆-LPA-chim(NtGi1-Gs-CtGq)/β1/γ2
14.29	Consensus	gq_cck	Orthosteric Ligand	8IA7-CCK_B-Cholecystokinin-8-chim(NtGi1L-Gq)/β1/γ2 7XOW-CCK_B-Gastrin-chim(NtGi1-Gq)/β1/γ2 7EZM-CCK_A-Cholecystokinin-8-chim(NtGsL-Gq)/β1/γ2 7F8W-CCK_B-Gastrin-17-chim(NtGsL-Gq)/β1/γ2
14.29	Consensus	gq_nucleotide	Orthosteric Ligand	gq_p2y
14.29	Consensus	gq_p2y	Orthosteric Ligand	7XXH-P2Y₁-2MeSADP-chim(NtGi1-G11)/β1/γ2
14.29	Consensus	neurotensin_off	Orthosteric Ligand	nts1_off
14.29	Consensus	nts1_off	Orthosteric Ligand	7UL2-NTS₁-SR48692-Na
13.79	Single	7DUQ	GLP-1	7DUQ-GLP-1-GLP-1-PubChem 156022738-Gs/β1/γ2
13.79	Single	7TYX	Amylin	7TYX-CT (AMY2)-Amylin-Gs/β1/γ2; RAMP2
13.79	Consensus	gi_npy	Orthosteric Ligand	8K6M-Y₁-Neuropeptide-Y-Gi2/β1/γ1 7X9C-Y₄-Pancreatic Hormone-Gi1/β1/γ2 7YOO-Y₂-Neuropeptide-Y-Gi1/β1/γ2
13.79	Consensus	npy_on	Orthosteric Ligand	npy1_on npy2_on npy4_on
13.79	Consensus	npy_on_gp	Orthosteric Ligand	npy1_on_gp npy2_on_gp npy4_on_gp
13.64	Single	7F8X	NN9056	7F8X-CCK_A-NN9056
13.64	Single	7RTB	Peptide-19	7RTB-GLP-1-Peptide-19-Gs/β1/γ2
13.64	Single	7T6U	CGEN-855A	7T6U-FPR2-ALX-CGEN-855A-Gi1/β1/γ2
13.64	Single	7WIC	Somatostatin-14	7WIC-SST2-Somatostatin-14-Gi1/β1/γ2
13.64	Single	7XAU	Octreotide	7XAU-SST2-Octreotide-Gi1/β1/γ2
13.64	Single	8DWG	Proenkephalin-A	8DWG-MRGPRX1-Proenkephalin-A-ML382-chim(NtGi2L-Gs-CtGq)/β1/γ2
13.64	Single	8F7X	Nociceptin	8F7X-NOP-Nociceptin-Gi1/β1/γ2
13.64	Single	8JIQ	Peptide-15	8JIQ-Glucagon-Peptide-15-Gs/β1/γ2
13.64	Single	8ZCJ	Pasireotide	8ZCJ-SST5-Pasireotide-Gi1/β1/γ1
13.64	Single	9BKJ	Cholecystokinin-8	9BKJ-CCK_A-Cholecystokinin-8-chim(NtGi1-Gs-CtGq)/β1/γ2
13.64	Consensus	chemerin_on_gp	Orthosteric Ligand	cml1_on_gp
13.64	Consensus	class-a_on_gp	Orthosteric Ligand	sensory_on_gp alicarboxylic_on_gp amine_on_gp lipid_on_gp nucleotide_on_gp peptide_on_gp protein_on_gp
13.64	Consensus	cml1_on	Orthosteric Ligand	7YKD-CML1-Chemerin-9-Gi1/β1/γ2
13.64	Consensus	gi_chemerin	Orthosteric Ligand	7YKD-CML1-Chemerin-9-Gi1/β1/γ2
13.64	Consensus	gi_nucleotide	Orthosteric Ligand	gi_adenosine gi_p2y
13.64	Consensus	mc4_on	Orthosteric Ligand	7AUE-MC₄-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2 7F58-MC₄-THIQ-Gs/β1/γ2 7F54-MC₄-Afamelanotide-Gs/β1/γ2 7F53-MC₄-α-MSH-Gs/β1/γ2 7F55-MC₄-Bremelanotide-Gs/β1/γ2
13.64	Consensus	nk3_on	Orthosteric Ligand	8JBF-NK₃-Senktide-chim(NtGi1-Gs-CtGq)/β1/γ2
13.64	Consensus	nk3_on_gp	Orthosteric Ligand	8JBF-NK₃-Senktide-chim(NtGi1-Gs-CtGq)/β1/γ2
13.64	Consensus	nop_on	Orthosteric Ligand	8F7X-NOP-Nociceptin-Gi1/β1/γ2
13.64	Consensus	nop_on_gp	Orthosteric Ligand	8F7X-NOP-Nociceptin-Gi1/β1/γ2
13.64	Consensus	somatostatin_off	Orthosteric Ligand	sst2_off
13.64	Consensus	sst5_on	Orthosteric Ligand	8X8L-SST5-Cortistatin-chim(NtGi1-Gs-CtGi1)/β1/γ2 8X8N-SST5-Octreotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
13.33	Single	3PWH	ZM-241385	3PWH-A_2A-ZM-241385
13.33	Single	3V2W	PubChem 51892645	3V2W-S1P₁-PubChem 51892645
13.33	Single	5K2D	ZM-241385	5K2D-A_2A-ZM-241385-Na
13.33	Single	5U09	Taranabant	5U09-CB₁-Taranabant
13.33	Single	6JZH	ZM-241385	6JZH-A_2A-ZM-241385-Na
13.33	Single	6PS7	ZM-241385	6PS7-A_2A-ZM-241385-Na
13.33	Single	6ZA8	RTI-3a	6ZA8-NTS₁-RTI-3a
13.33	Single	7BR3	Elagolix	7BR3-GnRH₁-Elagolix
13.33	Single	7F8U	Lintitript	7F8U-CCK_A-Lintitript
13.33	Single	7F8Y	Devazepide	7F8Y-CCK_A-Devazepide
13.33	Single	7LCJ	Danuglipron	7LCJ-GLP-1-Danuglipron
13.33	Single	7TZF	Amylin	7TZF-CT (AMY3)-Amylin-Gs/β1/γ2; RAMP3
13.33	Single	7VBH	Peptide-20	7VBH-GLP-1-Peptide-20-Gs/β1/γ2
13.33	Single	7VDL	Cortistatin-14	7VDL-MRGPRX2-Cortistatin-14-Gi1/β1/γ2
13.33	Single	7VUJ	JNJ-63533054	7VUJ-GPR139-JNJ-63533054-GDP-chim(Gs-CtGq)/β1/γ2
13.33	Single	7WF7	S1P	7WF7-S1P₁-S1P-Gi1/β1/γ2
13.33	Single	7X2C	Fenoldopam	7X2C-D₁-Fenoldopam-Fenoldopam-Gs/β1/γ2
13.33	Single	7XJJ	Galanin	7XJJ-GAL₁-Galanin-Go/β1/γ2
13.33	Single	8F2A	Pramlintide Analogue San385	8F2A-CT (AMY3)-Pramlintide Analogue San385-Gs/β1/γ2; RAMP3
13.33	Single	8IJB	Acipimox	8IJB-HCA₂-Acipimox-Gi1/β1/γ2
13.33	Single	8J6L	Niacin	8J6L-HCA₂-Niacin-Gi1/β1/γ2
13.33	Single	8RVW	StilSwitch3	8RVW-A_2A-StilSwitch3-Na
13.33	Single	8RW0	Istradefylline	8RW0-A_2A-Istradefylline-Na
13.33	Single	8U4P	AMD3100	8U4P-CXCR4-AMD3100-Cholesterol-Gi1/β1/γ2
13.33	Single	8U4S	REGN7663-Fab	8U4S-CXCR4-REGN7663-Fab
13.33	Single	8U4T	REGN7663-Fab	8U4T-CXCR4-REGN7663-Fab
13.33	Single	8UTD	MK1903	8UTD-HCA₂-MK1903-Gi1/β1/γ2
13.33	Consensus	gnrh1_off	Orthosteric Ligand	7BR3-GnRH₁-Elagolix
13.33	Consensus	s1p1_off	Orthosteric Ligand	3V2W-S1P₁-PubChem 51892645
13.04	Single	7EZK	Cholecystokinin-8	7EZK-CCK_A-Cholecystokinin-8-chim(NtGi1-Gs)/β1/γ2
13.04	Single	7PIV	Setmelanotide	7PIV-MC₄-Setmelanotide-Gs/β1/γ2
13.04	Single	7RKM	Fractalkine	7RKM-US28-Fractalkine-Gi1/β1/γ2
13.04	Single	7TRY	Urocortin	7TRY-CRF₂-Urocortin-chim(NtGi1-G11)/β1/γ2
13.04	Single	7WJ5	Somatostatin-14	7WJ5-SST2-Somatostatin-14-Gi1/β1/γ2
13.04	Single	8F7Q	Beta-Endorphin	8F7Q-μ-β-Endorphin-Gi1/β1/γ2
13.04	Single	8F7S	Deltorphin	8F7S-δ-Deltorphin-Gi1/β1/γ2
13.04	Single	8F7W	Dynorphin	8F7W-κ-Dynorphin-Gi1/β1/γ2
13.04	Single	8K6O	Pro-neuropeptide-Y	8K6O-Y₁-Pro-neuropeptide-Y-Gi2/β1/γ1
13.04	Single	9EAI	Nanobody AT209	9EAI-AT₁-Losartan-Nanobody AT209
13.04	Consensus	cckb_on	Orthosteric Ligand	8IA7-CCK_B-Cholecystokinin-8-chim(NtGi1L-Gq)/β1/γ2 7XOW-CCK_B-Gastrin-chim(NtGi1-Gq)/β1/γ2 7F8V-CCK_B-Gastrin-17-Gi2/β1/γ2
13.04	Consensus	dop_on_gp	Orthosteric Ligand	8F7S-δ-Deltorphin-Gi1/β1/γ2
13.04	Consensus	gi_cck	Orthosteric Ligand	7EZH-CCK_A-Cholecystokinin-8-Gi1/β1/γ2 7F8V-CCK_B-Gastrin-17-Gi2/β1/γ2
13.04	Consensus	mc4_on_gp	Orthosteric Ligand	7AUE-MC₄-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2 7F58-MC₄-THIQ-Gs/β1/γ2 7F54-MC₄-Afamelanotide-Gs/β1/γ2 7F53-MC₄-α-MSH-Gs/β1/γ2 7F55-MC₄-Bremelanotide-Gs/β1/γ2
13.04	Consensus	sst4_on	Orthosteric Ligand	7XMS-SST4-Somatostatin-14-Gi1/β1/γ2 7XMT-SST4-J-2156-Gi1/β1/γ2
13.04	Consensus	sst4_on_gp	Orthosteric Ligand	7XMS-SST4-Somatostatin-14-Gi1/β1/γ2 7XMT-SST4-J-2156-Gi1/β1/γ2
13.04	Consensus	tachykinin_on_gp	Orthosteric Ligand	nk1_on_gp nk2_on_gp nk3_on_gp
12.90	Single	8JIR	SAR425899	8JIR-GLP-1-SAR425899-chim(NtGi1-Gs)/β1/γ2
12.90	Consensus	gs_peptide	Orthosteric Ligand	gs_cck gs_melanocortin gs_vasop-oxy
12.82	Single	8GY7	Corticotropin	8GY7-MC₂-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1
12.50	Single	3V2Y	PubChem 51892645	3V2Y-S1P₁-PubChem 51892645
12.50	Single	5IU7	Q27456346	5IU7-A_2A-Q27456346-Na
12.50	Single	5JTB	ZM-241385	5JTB-A_2A-ZM-241385
12.50	Single	5K2B	ZM-241385	5K2B-A_2A-ZM-241385-Na
12.50	Single	5NLX	ZM-241385	5NLX-A_2A-ZM-241385-Na
12.50	Single	5UVI	ZM-241385	5UVI-A_2A-ZM-241385
12.50	Single	6AQF	ZM-241385	6AQF-A_2A-ZM-241385
12.50	Single	6D32	Cyclopamine	6D32-SMO-Cyclopamine-Cyclopamine
12.50	Single	6D35	Cholesterol	6D35-SMO-Cholesterol
12.50	Single	6N51	Quisqualate	6N51-mGlu5; mGlu5-Quisqualate
12.50	Single	6N51	Quisqualate	6N51-mGlu5; mGlu5-Quisqualate
12.50	Single	6UO8	SKF97541	6UO8-GABA_B1, GABA_B2-SKF97541-GS39783
12.50	Single	6UO9	SKF97541	6UO9-GABA_B1, GABA_B2-SKF97541
12.50	Single	6UUN	Adrenomedullin	6UUN-CT Like (AM1)-Adrenomedullin-Gs/β1/γ2; RAMP2
12.50	Single	6W2X	PubChem 5311042	6W2X-GABA_B1, GABA_B2-PubChem 5311042-PubChem 23727970
12.50	Single	6W2Y	PubChem 5311042	6W2Y-GABAB1; GABAB1-PubChem 5311042-PubChem 23727970
12.50	Single	6W2Y	PubChem 5311042	6W2Y-GABAB1; GABAB1-PubChem 5311042-PubChem 23727970
12.50	Single	6WJC	Muscarinic toxin 7	6WJC-M₁-Atropine-Muscarinic toxin 7
12.50	Single	6ZDR	HMS1413f12	6ZDR-A_2A-HMS1413f12-Na
12.50	Single	7ARO	LUF5833	7ARO-A_2A-LUF5833-Na
12.50	Single	7C7Q	Baclofen	7C7Q-GABA_B1, GABA_B2-Baclofen-PubChem 7023848
12.50	Single	7C7S	CGP54626	7C7S-GABA_B1, GABA_B2-CGP54626
12.50	Single	7CUM	CGP54626	7CUM-GABA_B1, GABA_B2-CGP54626-Phospholipid
12.50	Single	7DD5	Ca	7DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
12.50	Single	7DD5	Ca; Ca; Tryptophan; NPS-2143	7DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
12.50	Single	7DD5	Ca	7DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
12.50	Single	7DD5	Ca; Ca; Tryptophan; NPS-2143	7DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
12.50	Single	7DGE	Quisqualate	7DGE-mGlu1; mGlu1-Quisqualate
12.50	Single	7DTT	Ca	7DTT-CaS-Ca-Ca
12.50	Single	7DTT	Ca	7DTT-CaS-Ca-Ca
12.50	Single	7DTU	Tryptophan	7DTU-CaS-Tryptophan
12.50	Single	7DTU	Tryptophan	7DTU-CaS-Tryptophan
12.50	Single	7DTV	Ca	7DTV-CaS-Ca-Ca; Tryptophan
12.50	Single	7DTV	Ca; Tryptophan	7DTV-CaS-Ca-Ca; Tryptophan
12.50	Single	7DTV	Ca	7DTV-CaS-Ca-Ca; Tryptophan
12.50	Single	7DTV	Ca; Tryptophan	7DTV-CaS-Ca-Ca; Tryptophan
12.50	Single	7E6T	Ca	7E6T-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
12.50	Single	7E6T	Ca; Ca; Cyclomethyltryptophan; PO4	7E6T-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
12.50	Single	7E6T	Ca	7E6T-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
12.50	Single	7E6T	Ca; Ca; Cyclomethyltryptophan; PO4	7E6T-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
12.50	Single	7E9G	Eglumetad	7E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/β1/γ2
12.50	Single	7E9G	Eglumetad	7E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/β1/γ2
12.50	Single	7E9H	Phosphoserine	7E9H-mGlu4; mGlu4-Phosphoserine-Gi3/β1/γ2
12.50	Single	7E9H	Phosphoserine	7E9H-mGlu4; mGlu4-Phosphoserine-Gi3/β1/γ2
12.50	Single	7EB2	Baclofen	7EB2-GABAB2; GABAB1-Baclofen-rac-BHFF-Gi1/β1/γ2
12.50	Single	7EPB	Eglumetad	7EPB-mGlu2; mGlu2-Eglumetad
12.50	Single	7EPB	Eglumetad	7EPB-mGlu2; mGlu2-Eglumetad
12.50	Single	7F61	PF-03654746	7F61-H₃-PF-03654746-Cholesterol
12.50	Single	7FD8	Quisqualate	7FD8-mGlu5; mGlu5-Quisqualate
12.50	Single	7FD8	Quisqualate	7FD8-mGlu5; mGlu5-Quisqualate
12.50	Single	7FD9	LY341495	7FD9-mGlu5; mGlu5-LY341495
12.50	Single	7FD9	LY341495	7FD9-mGlu5; mGlu5-LY341495
12.50	Single	7FIH	hCG	7FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/β1/γ2
12.50	Single	7FII	hCG	7FII-LH-hCG-chim(NtGi1-Gs)/β1/γ2
12.50	Single	7M3E	Ca; Ca; Tryptophan; NPS-2143	7M3E-CaS-Ca; Ca; Tryptophan; NPS-2143
12.50	Single	7M3E	Ca; Ca; Tryptophan; NPS-2143	7M3E-CaS-Ca; Ca; Tryptophan; NPS-2143
12.50	Single	7M3F	Ca; Ca; Tryptophan; Cinacalcet; PO4	7M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
12.50	Single	7M3F	Ca; Ca; Tryptophan; Cinacalcet; PO4	7M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
12.50	Single	7M3G	Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4	7M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
12.50	Single	7M3G	Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4	7M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
12.50	Single	7M3G	Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4	7M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
12.50	Single	7M3G	Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4	7M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
12.50	Single	7MBX	Cholecystokinin-8	7MBX-CCK_A-Cholecystokinin-8-Gs/β1/γ1
12.50	Single	7MTQ	LY341495	7MTQ-mGlu2; mGlu2-LY341495
12.50	Single	7MTQ	LY341495	7MTQ-mGlu2; mGlu2-LY341495
12.50	Single	7MTR	Glutamate	7MTR-mGlu2; mGlu2-Glutamate-ADX55164
12.50	Single	7MTR	Glutamate	7MTR-mGlu2; mGlu2-Glutamate-ADX55164
12.50	Single	7MTS	Glutamate	7MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/β1/γ2
12.50	Single	7MTS	Glutamate	7MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/β1/γ2
12.50	Single	7O7F	6P4-CCL5	7O7F-CCR5-6P4-CCL5-Gi1/β1/γ1
12.50	Single	7RYC	Oxytocin	7RYC-OT-Oxytocin-chim(NtGi2L-Gs-CtGq)/β1/γ2
12.50	Single	7SIL	Ca	7SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
12.50	Single	7SIL	Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4	7SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
12.50	Single	7SIL	Ca	7SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
12.50	Single	7SIL	Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4	7SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
12.50	Single	7SIM	Ca	7SIM-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
12.50	Single	7SIM	Ca; Ca; Cyclomethyltryptophan; PO4	7SIM-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
12.50	Single	7SIM	Ca	7SIM-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
12.50	Single	7SIM	Ca; Ca; Cyclomethyltryptophan; PO4	7SIM-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
12.50	Single	7T9N	M22 Fab	7T9N-TSH-M22 Fab-PubChem 644078-Gs/β1/γ2
12.50	Single	7TYO	Calcitonin	7TYO-CT-Calcitonin-Gs/β1/γ2
12.50	Single	7TYY	Calcitonin-1	7TYY-CT (AMY2)-Calcitonin-1-Gs/β1/γ2; RAMP2
12.50	Single	7W55	Neuromedin-U-25	7W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
12.50	Single	7WI6	LY341495	7WI6-mGlu3; mGlu3-LY341495
12.50	Single	7WI6	LY341495	7WI6-mGlu3; mGlu3-LY341495
12.50	Single	7WI8	LY341495	7WI8-mGlu3; mGlu3-LY341495
12.50	Single	7WI8	LY341495	7WI8-mGlu3; mGlu3-LY341495
12.50	Single	7WIH	LY2794193	7WIH-mGlu3; mGlu3-LY2794193
12.50	Single	7WIH	LY2794193	7WIH-mGlu3; mGlu3-LY2794193
12.50	Single	7WVU	fMLF	7WVU-FPR1-ALX-fMLF-Gi1/β1/γ2
12.50	Single	7X9A	Neuropeptide-Y	7X9A-Y₁-Neuropeptide-Y-Gi1/β1/γ2
12.50	Single	7XOU	Cholecystokinin-8	7XOU-CCK_A-Cholecystokinin-8-Gs/β1/γ2
12.50	Single	7XOV	SR146131	7XOV-CCK_A-SR146131-Gs/β1/γ2
12.50	Single	7XW6	M22 Fab	7XW6-TSH-M22 Fab-ML109-Gs/β1/γ2
12.50	Single	7XW7	K1-70	7XW7-TSH-K1-70
12.50	Single	7YK6	PubChem 138319674	7YK6-RXFP4-PubChem 138319674-Gi2/β1/γ2
12.50	Single	8H4L	Doconexent	8H4L-FFA4-Doconexent-chim(NtGi1-Gs-CtGq)/β1/γ2
12.50	Single	8HQN	9-S-HODE	8HQN-GPR132-9-S-HODE-Gi1/β1/γ2
12.50	Single	8IY9	Niacin	8IY9-HCA₂-Niacin-Go/β1/γ2
12.50	Single	8JCU	LY341495	8JCU-mGlu2; mGlu3-LY341495
12.50	Single	8JCU	LY341495	8JCU-mGlu2; mGlu3-LY341495
12.50	Single	8JCV	LY341495	8JCV-mGlu2; mGlu3-LY341495
12.50	Single	8JCV	LY341495	8JCV-mGlu2; mGlu3-LY341495
12.50	Single	8JCW	LY341495	8JCW-mGlu2; mGlu3-LY341495
12.50	Single	8JCW	LY341495	8JCW-mGlu2; mGlu3-LY341495
12.50	Single	8JCX	LY341495	8JCX-mGlu2; mGlu3-LY341495
12.50	Single	8JCX	LY341495	8JCX-mGlu2; mGlu3-LY341495
12.50	Single	8JCY	LY341495	8JCY-mGlu2; mGlu3-LY341495
12.50	Single	8JCY	LY341495	8JCY-mGlu2; mGlu3-LY341495
12.50	Single	8JCZ	LY341495	8JCZ-mGlu2; mGlu3-LY341495
12.50	Single	8JCZ	LY341495	8JCZ-mGlu2; mGlu3-LY341495
12.50	Single	8JD0	Glutamate	8JD0-mGlu2; mGlu3-Glutamate-NAM563
12.50	Single	8JD1	Glutamate	8JD1-mGlu2; mGlu3-Glutamate
12.50	Single	8JD1	Glutamate	8JD1-mGlu2; mGlu3-Glutamate
12.50	Single	8JD2	Glutamate	8JD2-mGlu2; mGlu3-Glutamate
12.50	Single	8JD2	Glutamate	8JD2-mGlu2; mGlu3-Glutamate
12.50	Single	8JD3	Glutamate	8JD3-mGlu2; mGlu3-Glutamate-HZR; PEF-Gi1/β1/γ2
12.50	Single	8JD3	Glutamate	8JD3-mGlu2; mGlu3-Glutamate-HZR; PEF-Gi1/β1/γ2
12.50	Single	8JD4	Glutamate	8JD4-mGlu2; mGlu4-Glutamate
12.50	Single	8JD4	Glutamate	8JD4-mGlu2; mGlu4-Glutamate
12.50	Single	8JD5	Glutamate	8JD5-mGlu2; mGlu4-Glutamate-BQI; HZE; PEF-Gi1/β1/γ2
12.50	Single	8JD5	Glutamate	8JD5-mGlu2; mGlu4-Glutamate-BQI; HZE; PEF-Gi1/β1/γ2
12.50	Single	8JD6	Phosphoserine	8JD6-mGlu4; mGlu4-Phosphoserine-N-(3-chlorophenyl)pyridine-2-carboxamide-Gi3/β1/γ2
12.50	Single	8JD6	Phosphoserine	8JD6-mGlu4; mGlu4-Phosphoserine-N-(3-chlorophenyl)pyridine-2-carboxamide-Gi3/β1/γ2
12.50	Single	8JER	Acipimox	8JER-HCA₂-Acipimox-Go/β1/γ2
12.50	Single	8K4N	VF0	8K4N-GPR34-VF0-Gi1/β1/γ2
12.50	Single	8K5C	Acipimox	8K5C-HCA₂-Acipimox
12.50	Single	8RQQ	ZM-241385	8RQQ-A_2A-ZM-241385-Na
12.50	Single	8RWC	StilSwitch2	8RWC-A_2A-StilSwitch2-Na
12.50	Single	8RWD	StilSwitch3	8RWD-A_2A-StilSwitch3-Na
12.50	Single	8RWI	StilSwitch2	8RWI-A_2A-StilSwitch2-Na
12.50	Single	8SZF	Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW	8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
12.50	Single	8SZF	Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW	8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
12.50	Single	8SZF	Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW	8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
12.50	Single	8SZG	Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW	8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-chim(NtGi1-Gq)/β1/γ2
12.50	Single	8SZG	Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW	8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-chim(NtGi1-Gq)/β1/γ2
12.50	Single	8SZH	Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW	8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/β1/γ2
12.50	Single	8SZH	Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW	8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/β1/γ2
12.50	Single	8SZI	Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW	8SZI-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi3/β1/γ2
12.50	Single	8SZI	Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW	8SZI-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi3/β1/γ2
12.50	Single	8T7H	Quisqualate	8T7H-mGlu5; mGlu5-Quisqualate
12.50	Single	8T7H	Quisqualate	8T7H-mGlu5; mGlu5-Quisqualate
12.50	Single	8T8M	Quisqualate	8T8M-mGlu5; mGlu5-Quisqualate
12.50	Single	8T8M	Quisqualate	8T8M-mGlu5; mGlu5-Quisqualate
12.50	Single	8TAO	Quisqualate	8TAO-mGlu5; mGlu5-Quisqualate-CDPPB
12.50	Single	8TAO	Quisqualate	8TAO-mGlu5; mGlu5-Quisqualate-CDPPB
12.50	Single	8TQB	Ca; PAM VU6023326	8TQB-mGlu3; mGlu3-Ca; PAM VU6023326-Ca
12.50	Single	8TQB	Ca; PAM VU6023326	8TQB-mGlu3; mGlu3-Ca; PAM VU6023326-Ca
12.50	Single	8TR0	LY341495	8TR0-mGlu3; mGlu3-LY341495
12.50	Single	8TR0	LY341495	8TR0-mGlu3; mGlu3-LY341495
12.50	Single	8TR2	Ca; LY379268	8TR2-mGlu3; mGlu3-Ca; LY379268-Ca
12.50	Single	8TR2	Ca; LY379268	8TR2-mGlu3; mGlu3-Ca; LY379268-Ca
12.50	Single	8TRC	LY341495	8TRC-mGlu3; mGlu3-LY341495
12.50	Single	8TRC	LY341495	8TRC-mGlu3; mGlu3-LY341495
12.50	Single	8TRD	LY341495	8TRD-mGlu3; mGlu3-LY341495
12.50	Single	8TRD	LY341495	8TRD-mGlu3; mGlu3-LY341495
12.50	Single	8WG9	(2S)-2-amino-4-phosphonobutanoic acid	8WG9-mGlu4; mGlu2-(2S)-2-amino-4-phosphonobutanoic acid
12.50	Single	8WGB	Glutammate	8WGB-mGlu4; mGlu2-Glutammate-W9R-Gi3/β1/γ2
12.50	Single	8WGB	Glutammate	8WGB-mGlu4; mGlu2-Glutammate-W9R-Gi3/β1/γ2
12.50	Single	8WGC	LY379268	8WGC-mGlu4; mGlu2-LY379268
12.50	Single	8WGD	WAG/WA6	8WGD-mGlu4; mGlu2-WAG/WA6
12.50	Single	8WGD	WAG/WA6	8WGD-mGlu4; mGlu2-WAG/WA6
12.50	Single	8WKZ	SBL-MC-31	8WKZ-MC₄-SBL-MC-31
12.50	Single	8WPG	Tryptophan; Cinacalcet; PO4; Ca	8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
12.50	Single	8WPG	Tryptophan; Cinacalcet; PO4; Ca	8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
12.50	Single	8WPU	Tryptophan; Cinacalcet; PO4; Ca	8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/β1/γ2
12.50	Single	8WPU	Tryptophan; Cinacalcet; PO4; Ca	8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/β1/γ2
12.50	Single	8WVX	Norrin	8WVX-LGR4-Norrin
12.50	Single	8WVY	Norrin	8WVY-LGR4-Norrin
12.50	Single	8X0B	Quisqualate	8X0B-mGlu5; mGlu5-Quisqualate-VU0424465
12.50	Single	8X0B	Quisqualate	8X0B-mGlu5; mGlu5-Quisqualate-VU0424465
12.50	Single	8X0C	Quisqualate	8X0C-mGlu5; mGlu5-Quisqualate-VU0424465
12.50	Single	8X0C	Quisqualate	8X0C-mGlu5; mGlu5-Quisqualate-VU0424465
12.50	Single	8X0D	Quisqualate	8X0D-mGlu5; mGlu5-Quisqualate-VU0424465
12.50	Single	8X0D	Quisqualate	8X0D-mGlu5; mGlu5-Quisqualate-VU0424465
12.50	Single	8X0E	Quisqualate	8X0E-mGlu5; mGlu5-Quisqualate
12.50	Single	8X0E	Quisqualate	8X0E-mGlu5; mGlu5-Quisqualate
12.50	Single	8X0F	Quisqualate	8X0F-mGlu5; mGlu5-Quisqualate-VU0424465
12.50	Single	8X0F	Quisqualate	8X0F-mGlu5; mGlu5-Quisqualate-VU0424465
12.50	Single	8X0G	Quisqualate	8X0G-mGlu5; mGlu5-Quisqualate
12.50	Single	8X0G	Quisqualate	8X0G-mGlu5; mGlu5-Quisqualate
12.50	Single	8X0H	Quisqualate	8X0H-mGlu5; mGlu5-Quisqualate
12.50	Single	8X0H	Quisqualate	8X0H-mGlu5; mGlu5-Quisqualate
12.50	Single	8XUM	R-spondin-2	8XUM-LGR4-R-spondin-2
12.50	Single	8Y62	C16:0 Ceramide	8Y62-FPR2-ALX-C16:0 Ceramide-Gi1/β1/γ2
12.50	Single	8ZPN	AMD3100	8ZPN-CXCR4-AMD3100-Cholesterol
12.50	Single	9ASB	Ca	9ASB-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
12.50	Single	9ASB	Ca; Ca; Cyclomethyltryptophan; 9IG; PO4	9ASB-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
12.50	Single	9AVG	Ca	9AVG-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs)/β1/γ2
12.50	Single	9AVG	Ca; Ca; Cyclomethyltryptophan; 9IG; PO4	9AVG-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs)/β1/γ2
12.50	Single	9AVL	Ca	9AVL-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi3/β2/γ2
12.50	Single	9AVL	Ca; Ca; Cyclomethyltryptophan; 9IG; PO4	9AVL-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi3/β2/γ2
12.50	Single	9AVL	Ca	9AVL-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi3/β2/γ2
12.50	Single	9AVL	Ca; Ca; Cyclomethyltryptophan; 9IG; PO4	9AVL-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi3/β2/γ2
12.50	Single	9AXF	Ca	9AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
12.50	Single	9AXF	Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4	9AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
12.50	Single	9AXF	Ca	9AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
12.50	Single	9AXF	Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4	9AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
12.50	Single	9AYF	Ca	9AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/β1/γ2
12.50	Single	9AYF	Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4	9AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/β1/γ2
12.50	Single	9C1P	Ca	9C1P-CaS-Ca-Ca; Tryptophan; '6218; PO4
12.50	Single	9C1P	Ca; Tryptophan; '6218; PO4	9C1P-CaS-Ca-Ca; Tryptophan; '6218; PO4
12.50	Single	9C1P	Ca	9C1P-CaS-Ca-Ca; Tryptophan; '6218; PO4
12.50	Single	9C1P	Ca; Tryptophan; '6218; PO4	9C1P-CaS-Ca-Ca; Tryptophan; '6218; PO4
12.50	Single	9C2F	Ca	9C2F-CaS-Ca-Ca; Ca; Tryptophan; '6218; PO4
12.50	Single	9C2F	Ca; Ca; Tryptophan; '6218; PO4	9C2F-CaS-Ca-Ca; Ca; Tryptophan; '6218; PO4
12.50	Single	9C2F	Ca	9C2F-CaS-Ca-Ca; Ca; Tryptophan; '6218; PO4
12.50	Single	9C2F	Ca; Ca; Tryptophan; '6218; PO4	9C2F-CaS-Ca-Ca; Ca; Tryptophan; '6218; PO4
12.50	Single	9II2	Glutamate	9II2-mGlu3; mGlu3-Glutamate-Arrestin2
12.50	Single	9II2	Glutamate	9II2-mGlu3; mGlu3-Glutamate-Arrestin2
12.50	Single	9II3	Glutamate	9II3-mGlu3; mGlu3-Glutamate-Arrestin2
12.50	Single	9II3	Glutamate	9II3-mGlu3; mGlu3-Glutamate-Arrestin2
12.50	Consensus	a2_off	Orthosteric Ligand	a2a_off
12.50	Consensus	a2a_off	Orthosteric Ligand	3RFM-A_2A-Caffeine 8C9W-A_2A-Etrumadenant 3UZA-A_2A-GTPL9236 8GNG-A_2A-Istradefylline 8CU6-A_2A-LJ-4517 7PX4-A_2A-PSB-2113 7PYR-A_2A-PSB-2115 8DU3-A_2A-PubChem 105526064 8JWY-A_2A-2-118 8PWN-A_2A-Theophylline 5IU4-A_2A-ZM-241385-Na 5OLZ-A_2A-PubChem 135566609-Na 6GT3-A_2A-Imaradenant-Na 5OLV-A_2A-LUAA41063-Na 5N2R-A_2A-PSB-36-Na 5IU7-A_2A-Q27456346-Na 5OLH-A_2A-Vipadenant-Na 5OLO-A_2A-Tozadenant-Na 6ZDR-A_2A-HMS1413f12-Na 8GNE-A_2A-KW-6356-Na 8JWZ-A_2A-AB928-Na 5IU8-A_2A-Q27456347-Na 5IUB-A_2A-Q27456344-Na 6ZDV-A_2A-Chromone 5d-Na 5IUA-A_2A-Q27456348-Na 8A2P-A_2A-LUAA47070-Na
12.50	Consensus	cb1_off	Orthosteric Ligand	5U09-CB₁-Taranabant 5TGZ-CB₁-AM6538
12.50	Consensus	cckb_on_gp	Orthosteric Ligand	8IA7-CCK_B-Cholecystokinin-8-chim(NtGi1L-Gq)/β1/γ2 7XOW-CCK_B-Gastrin-chim(NtGi1-Gq)/β1/γ2 7F8V-CCK_B-Gastrin-17-Gi2/β1/γ2
12.50	Consensus	fpr2-alx_on	Orthosteric Ligand	7WVX-FPR2-ALX-Humanin-Gi2/β1/γ2 7T6U-FPR2-ALX-CGEN-855A-Gi1/β1/γ2 7T6V-FPR2-ALX-fMLFII-Gi1/β1/γ2 7WVY-FPR2-ALX-Amyloid-β42-Gi2/β1/γ2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/β1/γ2 6OMM-FPR2-ALX-WKYMVX-Gi1/β1/γ2
12.50	Consensus	gs_cck	Orthosteric Ligand	7MBX-CCK_A-Cholecystokinin-8-Gs/β1/γ1
12.50	Consensus	nmur2_on	Orthosteric Ligand	7W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
12.50	Consensus	nmur2_on_gp	Orthosteric Ligand	7W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
12.12	Single	6E3Y	Calcitonin gene-related peptide-1	6E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/β1/γ2; RAMP1
12.00	Single	6M1I	PACAP	6M1I-PAC₁-PACAP-Gs/β1/γ2
12.00	Single	6WI9	Secretin	6WI9-Secretin-Secretin-Gs/β1/γ2
12.00	Single	7DW9	AVP	7DW9-V₂-AVP-chim(NtGi1-Gs)/β1/γ2
12.00	Single	7FIM	Tirzepatide	7FIM-GLP-1-Tirzepatide-Gs/β1/γ2
12.00	Single	7FIN	Peptide-20; GGL	7FIN-GIP-Peptide-20; GGL-Gs/β1/γ2
12.00	Single	7TYI	Amylin	7TYI-CT-Amylin-Gs/β1/γ2
12.00	Single	7W40	Bombesin	7W40-BB₂-Bombesin-chim(NtGi1L-Gq)/β1/γ2
12.00	Single	7W57	Neuromedin-S	7W57-NMUR2-Neuromedin-S-chim(NtGi1-Gs-CtGq)/β1/γ2
12.00	Single	7XK8	Neuromedin-U-25	7XK8-NMUR2-Neuromedin-U-25-Gi1/β1/γ2
12.00	Single	8H4K	GW9508	8H4K-FFA4-GW9508-chim(NtGi1-Gs-CtGq)/β1/γ2
12.00	Single	8HA0	PTH	8HA0-PTH1-PTH-chim(NtGi1-Gs)/β1/γ2
12.00	Single	8IHF	MK6892	8IHF-HCA₂-MK6892-Gi1/β1/γ2
12.00	Single	8WST	Pro-MCH	8WST-MCH2-Pro-MCH-chim(NtGi1L-Gs-CtGq)/β1/γ2
12.00	Single	8XWQ	Endothelin-1	8XWQ-ET_B-Endothelin-1-Gi1/β1/γ2
12.00	Single	8YW4	Retatrutide	8YW4-GIP-Retatrutide-chim(NtGi1-Gs)/β1/γ22
12.00	Single	8YW5	Retatrutide	8YW5-Glucagon-Retatrutide-Gs/β1/γ2
12.00	Single	9BKK	Cholecystokinin-8	9BKK-CCK_A-Cholecystokinin-8-chim(NtGi1-Gs-CtGq)/β1/γ2
12.00	Consensus	apelin_on	Orthosteric Ligand	8XZH-Apelin-MM07-Gi1/β1/γ2 7W0M-Apelin-PubChem 122701908-Gi1/β1/γ2 8XZJ-Apelin-WN353-Gi1/β1/γ2 8XZF-Apelin-WN561-Gi1/β1/γ2 8XZG-Apelin-Apelin-13-Gi1/β1/γ2
12.00	Consensus	apelin_on_gp	Orthosteric Ligand	8XZH-Apelin-MM07-Gi1/β1/γ2 7W0M-Apelin-PubChem 122701908-Gi1/β1/γ2 8XZJ-Apelin-WN353-Gi1/β1/γ2 8XZF-Apelin-WN561-Gi1/β1/γ2 8XZG-Apelin-Apelin-13-Gi1/β1/γ2
12.00	Consensus	cxcr3_on_gp	Orthosteric Ligand	8HNK-CXCR3-CXCL11-Gi1/β1/γ2 8HNL-CXCR3-PS372424-Gi1/β1/γ2
12.00	Consensus	fpr2-alx_on_gp	Orthosteric Ligand	7WVX-FPR2-ALX-Humanin-Gi2/β1/γ2 7T6U-FPR2-ALX-CGEN-855A-Gi1/β1/γ2 7T6V-FPR2-ALX-fMLFII-Gi1/β1/γ2 7WVY-FPR2-ALX-Amyloid-β42-Gi2/β1/γ2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/β1/γ2 6OMM-FPR2-ALX-WKYMVX-Gi1/β1/γ2
12.00	Consensus	gs_vasop-oxy	Orthosteric Ligand	7DW9-V₂-AVP-chim(NtGi1-Gs)/β1/γ2
12.00	Consensus	neuromedin-u_on	Orthosteric Ligand	nmur1_on nmur2_on
12.00	Consensus	tachykinin_on	Orthosteric Ligand	nk1_on nk2_on nk3_on
12.00	Consensus	v2_on	Orthosteric Ligand	7DW9-V₂-AVP-chim(NtGi1-Gs)/β1/γ2
12.00	Consensus	v2_on_gp	Orthosteric Ligand	7DW9-V₂-AVP-chim(NtGi1-Gs)/β1/γ2
12.00	Consensus	vasop-oxy_on	Orthosteric Ligand	v2_on
12.00	Consensus	vasop-oxy_on_gp	Orthosteric Ligand	v2_on_gp
11.76	Single	3EML	ZM-241385	3EML-A_2A-ZM-241385
11.76	Single	5K2A	ZM-241385	5K2A-A_2A-ZM-241385-Na
11.76	Single	5TGZ	AM6538	5TGZ-CB₁-AM6538
11.76	Single	5UEN	DU172	5UEN-A₁-DU172
11.76	Single	5VRA	ZM-241385	5VRA-A_2A-ZM-241385-Na
11.76	Single	6D27	CAY10471	6D27-DP₂-CAY10471
11.76	Single	6FKC	PubChem 132473039	6FKC-Rhodopsin-PubChem 132473039
11.76	Single	6S0L	ZM-241385	6S0L-A_2A-ZM-241385
11.76	Single	7LCI	Danuglipron	7LCI-GLP-1-Danuglipron-Gs/β1/γ2
11.76	Single	7YK7	DC591053	7YK7-RXFP4-DC591053-Gi2/β1/γ2
11.76	Single	7YXA	ONO-5430608	7YXA-S1P₅-ONO-5430608
11.76	Single	8IHJ	Acifran	8IHJ-HCA₃-Acifran-Gi1/β1/γ2
11.76	Single	8J6P	Niacin	8J6P-HCA₂-Niacin-Compound 9n-Gi1/β1/γ2
11.76	Single	8JII	Niacin	8JII-HCA₂-Niacin-Compound 9n-Gi1/β1/γ2
11.76	Single	8RW7	StilSwitch1	8RW7-A_2A-StilSwitch1-Na
11.76	Single	8RWX	StilSwitch3	8RWX-A_2A-StilSwitch3-Na
11.76	Single	8XJL	PGF2-alpha	8XJL-FP-alpha-PGF2-α-chim(NtGi2-Gs-CtGq)/β1/γ2
11.76	Single	8ZBE	Octreotide	8ZBE-SST5-Octreotide-Gi1/β1/γ1
11.76	Single	9IVG	GLP-1 (Truncated)	9IVG-GLP-1-GLP-1 (Truncated)-chim(NtGi1-Gs)/β1/γ2
11.76	Consensus	a3_on	Orthosteric Ligand	a3a_on
11.76	Consensus	cck_off	Orthosteric Ligand	ccka_off
11.76	Consensus	ccka_off	Orthosteric Ligand	7F8Y-CCK_A-Devazepide 7F8U-CCK_A-Lintitript
11.76	Consensus	gi_hca	Orthosteric Ligand	8J6R-HCA₂-MK6892-Gi1/β1/γ2 8JIM-HCA₂-MMF-Gi1/β1/γ2 8IHI-HCA₂-Acifran-Gi1/β1/γ2 8IHH-HCA₂-LUF6283-Gi1/β1/γ2 8I7V-HCA₂-Acipimox-Gi1/β1/γ2 8I7W-HCA₂-GSK256073-Gi1/β1/γ2
11.76	Consensus	hca2_on	Orthosteric Ligand	8J6R-HCA₂-MK6892-Gi1/β1/γ2 8JIM-HCA₂-MMF-Gi1/β1/γ2 8I7V-HCA₂-Acipimox-Gi1/β1/γ2 8I7W-HCA₂-GSK256073-Gi1/β1/γ2 8IHH-HCA₂-LUF6283-Gi1/β1/γ2 8IHI-HCA₂-Acifran-Gi1/β1/γ2
11.76	Consensus	hca2_on_gp	Orthosteric Ligand	8J6R-HCA₂-MK6892-Gi1/β1/γ2 8IHI-HCA₂-Acifran-Gi1/β1/γ2 8IHH-HCA₂-LUF6283-Gi1/β1/γ2 8I7V-HCA₂-Acipimox-Gi1/β1/γ2 8JIM-HCA₂-MMF-Gi1/β1/γ2 8I7W-HCA₂-GSK256073-Gi1/β1/γ2
11.76	Consensus	hca_on_gp	Orthosteric Ligand	hca2_on_gp
11.76	Consensus	lipid_off	Orthosteric Ligand	cannabinoid_off paf_off lpl_off prostanoid_off leukotriene_off
11.54	Single	7LLY	Oxyntomodulin	7LLY-GLP-1-Oxyntomodulin-Gs/β1/γ2
11.54	Single	7P02	Protachykinin-1	7P02-NK₁-Protachykinin-1-chim(NtGi1-Gs)/β1/γ2
11.54	Single	7TYW	Calcitonin-1	7TYW-CT (AMY1)-Calcitonin-1-Gs/β1/γ2; RAMP1
11.54	Single	7VL9	CCL15(26-92)	7VL9-CCR1-CCL15(26-92)-Gi1/β1/γ2
11.54	Single	7WBJ	PACAP27	7WBJ-VPAC₁-PACAP27-Gs/β1/γ2
11.54	Single	7X9C	Pancreatic Hormone	7X9C-Y₄-Pancreatic Hormone-Gi1/β1/γ2
11.54	Single	7Y35	Abaloparatide	7Y35-PTH1-Abaloparatide-Gs/β1/γ2
11.54	Single	8IA2	C5a anaphylatoxin	8IA2-C5a₁-C5a anaphylatoxin-Go/β1/γ2
11.54	Single	8WWK	MCH	8WWK-MCH1-MCH-Gi1/β1/γ2
11.54	Single	8WWM	MCH	8WWM-MCH1-MCH-Gi1/β1/γ2
11.54	Consensus	chemokine_off	Orthosteric Ligand	ccr_off cxcr_off
11.54	Consensus	cml1_on_gp	Orthosteric Ligand	7YKD-CML1-Chemerin-9-Gi1/β1/γ2
11.54	Consensus	neuromedin-u_on_gp	Orthosteric Ligand	nmur1_on_gp nmur2_on_gp
11.54	Consensus	sst5_on_gp	Orthosteric Ligand	8X8L-SST5-Cortistatin-chim(NtGi1-Gs-CtGi1)/β1/γ2 8X8N-SST5-Octreotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
11.11	Single	5YHL	PubChem 135121352	5YHL-EP₄-PubChem 135121352
11.11	Single	5YWY	ONO-AE3-208	5YWY-EP₄-ONO-AE3-208
11.11	Single	5ZBQ	UR-MK-299	5ZBQ-Y₁-UR-MK-299
11.11	Single	6D26	Fevipiprant	6D26-DP₂-Fevipiprant
11.11	Single	6FJ3	PTH	6FJ3-PTH1-PTH
11.11	Single	6M9T	Misoprostol-FA	6M9T-EP₃-Misoprostol-FA
11.11	Single	6NBF	Long-Acting PTH Analog	6NBF-PTH1-Long-Acting PTH Analog-Gs/β1/γ2
11.11	Single	6NBI	Long-Acting PTH Analog	6NBI-PTH1-Long-Acting PTH Analog-Gs/β1/γ2
11.11	Single	6P9Y	PACAP	6P9Y-PAC₁-PACAP-Gs/β1/γ2
11.11	Single	6RZ4	Pranlukast	6RZ4-CysLT₁-Pranlukast-Na
11.11	Single	7CFN	INT-777	7CFN-GPBA-INT-777-Gs/β1/γ2
11.11	Single	7CZ5	Somatoliberin	7CZ5-GHRH-Somatoliberin-Gs/β1/γ2
11.11	Single	7DD6	Ca	7DD6-CaS-Ca-Ca; Ca; Tryptophan
11.11	Single	7DD6	Ca; Ca; Tryptophan	7DD6-CaS-Ca-Ca; Ca; Tryptophan
11.11	Single	7DD6	Ca	7DD6-CaS-Ca-Ca; Ca; Tryptophan
11.11	Single	7DD6	Ca; Ca; Tryptophan	7DD6-CaS-Ca-Ca; Ca; Tryptophan
11.11	Single	7DD7	Ca	7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
11.11	Single	7DD7	Ca; Ca; Tryptophan; Evocalcet	7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
11.11	Single	7DD7	Ca	7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
11.11	Single	7DD7	Ca; Ca; Tryptophan; Evocalcet	7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
11.11	Single	7EO2	FTY720-P	7EO2-S1P₁-FTY720-P-Gi1/β1/γ2
11.11	Single	7F8V	Gastrin-17	7F8V-CCK_B-Gastrin-17-Gi2/β1/γ2
11.11	Single	7RA3	GIP	7RA3-GIP-GIP-chim(NtGi1-Gs)/β1/γ2
11.11	Single	7TD3	S1P	7TD3-S1P₁-S1P-Gi1/β1/γ2
11.11	Single	7VAB	Non-Acylated Tirzepatide	7VAB-GIP-Non-Acylated Tirzepatide-chim(NtGi1-Gs)/β1/γ2
11.11	Single	7VUH	JNJ-63533054	7VUH-GPR139-JNJ-63533054-chim(Gs-CtGq)/β1/γ2
11.11	Single	7VV0	PAMP-12	7VV0-MRGPRX2-PAMP-12
11.11	Single	7Y26	Octreotide	7Y26-SST2-Octreotide-chim(NtGi2L-Gs-CtGq)/β1/γ2
11.11	Single	7YKD	Chemerin-9	7YKD-CML1-Chemerin-9-Gi1/β1/γ2
11.11	Single	8F0J	Pramlintide Analogue San45	8F0J-CT-Pramlintide Analogue San45-Gs/β1/γ2
11.11	Single	8FLR	PTHrP(1-36)	8FLR-PTH1-PTHrP(1-36)-Gs/β1/γ2
11.11	Single	8GD9	Rivenprost	8GD9-EP₄-Rivenprost-Gs/β1/γ2
11.11	Single	8H0P	NMB30	8H0P-BB₁-NMB30-chim(NtGi1-Gs-CtGq)/β1/γ2
11.11	Single	8ID4	Linoleic acid	8ID4-FFA4-Linoleic acid-Gi1/β1/γ2
11.11	Single	8IZ4	Lysophosphatidylserine	8IZ4-GPR34-Lysophosphatidylserine-Gi1/β1/γ2
11.11	Single	8J6J	GSK256073	8J6J-HCA₂-GSK256073-Gi1/β1/γ2
11.11	Single	8S4D	CMF-019	8S4D-Apelin-CMF-019
11.11	Single	8TF5	Oleic acid	8TF5-GPR6-Oleic acid
11.11	Single	8VVE	norBNI	8VVE-κ-norBNI-Gi1/β1/γ2
11.11	Single	8WGB	W9R	8WGB-mGlu4; mGlu2-Glutammate-W9R-Gi3/β1/γ2
11.11	Single	9ASB	Ca	9ASB-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
11.11	Single	9ASB	Ca; Ca; Cyclomethyltryptophan; 9IG; PO4	9ASB-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
11.11	Single	9AVG	Ca	9AVG-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs)/β1/γ2
11.11	Single	9AVG	Ca; Ca; Cyclomethyltryptophan; 9IG; PO4	9AVG-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs)/β1/γ2
11.11	Single	9AYF	Ca	9AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/β1/γ2
11.11	Single	9AYF	Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4	9AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/β1/γ2
11.11	Consensus	a3_on_gp	Orthosteric Ligand	a3a_on_gp
11.11	Consensus	a3a_on	Orthosteric Ligand	8X17-A_3A-Namodenoson-Gi1/β1/γ2 8X16-A_3A-Piclidenoson-Gi1/β1/γ2
11.11	Consensus	a3a_on_gp	Orthosteric Ligand	8X17-A_3A-Namodenoson-Gi1/β1/γ2 8X16-A_3A-Piclidenoson-Gi1/β1/γ2
11.11	Consensus	dp2_off	Orthosteric Ligand	6D26-DP₂-Fevipiprant
11.11	Consensus	dp_off	Orthosteric Ligand	dp2_off
11.11	Consensus	ep4_off	Orthosteric Ligand	5YWY-EP₄-ONO-AE3-208 5YHL-EP₄-PubChem 135121352
11.11	Consensus	ep_off	Orthosteric Ligand	ep4_off
11.11	Consensus	lipid_on	Orthosteric Ligand	cannabinoid_on ffa_on lpl_on prostanoid_on leukotriene_on
11.11	Consensus	lipid_on_gp	Orthosteric Ligand	cannabinoid_on_gp ffa_on_gp lpl_on_gp prostanoid_on_gp leukotriene_on_gp
11.11	Consensus	npy4_on	Orthosteric Ligand	7X9C-Y₄-Pancreatic Hormone-Gi1/β1/γ2
11.11	Consensus	npy4_on_gp	Orthosteric Ligand	7X9C-Y₄-Pancreatic Hormone-Gi1/β1/γ2
11.11	Consensus	nucleotide_on	Orthosteric Ligand	adenosine_on p2y_on
11.11	Consensus	rxfp4_on	Orthosteric Ligand	7YK7-RXFP4-DC591053-Gi2/β1/γ2 7YJ4-RXFP4-INSL5-Gi2/β1/γ2 7YK6-RXFP4-PubChem 138319674-Gi2/β1/γ2
11.11	Consensus	rxfp4_on_gp	Orthosteric Ligand	7YK7-RXFP4-DC591053-Gi2/β1/γ2 7YJ4-RXFP4-INSL5-Gi2/β1/γ2 7YK6-RXFP4-PubChem 138319674-Gi2/β1/γ2
10.81	Single	8F2B	Pramlintide Analogue San45	8F2B-CT (AMY3)-Pramlintide Analogue San45-Gs/β1/γ2; RAMP3
10.71	Single	5NX2	GLP-1 (Truncated)	5NX2-GLP-1-GLP-1 (Truncated)
10.71	Single	6B3J	Exendin-P5	6B3J-GLP-1-Exendin-P5-Gs/β1/γ2
10.71	Single	6UVA	Adrenomedullin-2	6UVA-CT Like (AM2)-Adrenomedullin-2-Gs/β1/γ2; RAMP3
10.71	Single	7DTY	GIP	7DTY-GIP-GIP-Gs/β1/γ2
10.71	Single	7F4F	Afamelanotide	7F4F-MC₁-Afamelanotide-chim(NtGi1-Gs)/β1/γ2
10.71	Single	7FIY	Tirzepatide	7FIY-GIP-Tirzepatide-Gs/β1/γ2
10.71	Single	7VQX	PACAP27	7VQX-VPAC₁-PACAP27-Gs/β1/γ2
10.71	Single	7VVK	PTH	7VVK-PTH1-PTH-Gs/β1/γ2
10.71	Single	8FEG	(DNCP)-Beta-Naloxamine	8FEG-κ-(DNCP)-β-Naloxamine-Gi1/β1/γ2
10.71	Single	8FU6	Glucagon derivative ZP3780	8FU6-Glucagon-Glucagon derivative ZP3780-Gs/β1/γ2
10.71	Single	8HAO	PTH	8HAO-PTH1-PTH-chim(NtGi1-Gs)/β1/γ2
10.71	Single	8WWL	MCH	8WWL-MCH1-MCH-Gi1/β1/γ2
10.71	Single	8ZH8	QRF-Amide	8ZH8-QRFP-QRF-Amide-Gq/β1/γ1
10.53	Single	4IAQ	Dihydroergotamine	4IAQ-5-HT_1B-Dihydroergotamine
10.53	Single	6RZ5	Zafirlukast	6RZ5-CysLT₁-Zafirlukast-Na
10.53	Single	7R0C	AVP	7R0C-V₂-AVP-Arrestin2
10.53	Single	7TUY	GSK682753A	7TUY-GPR183-GSK682753A
10.53	Single	7VIG	CBP-307	7VIG-S1P₁-CBP-307-Gi1/β1/γ2
10.53	Single	7XWO	Neurokinin-A	7XWO-NK₂-Neurokinin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
10.53	Single	7Y24	Octreotide	7Y24-SST2-Octreotide-Go/β1/γ2
10.53	Single	7Y67	C089 peptide	7Y67-C5a₁-C089 peptide-Gi1/β1/γ2
10.53	Single	8JBG	Neurokinin-B	8JBG-NK₃-Neurokinin-B-chim(NtGi1-Gs-CtGq)/β1/γ2
10.53	Single	8JGF	BAM8-22	8JGF-MRGPRX1-BAM8-22-chim(NtGi1-Gs-CtGq)/β1/γ2
10.53	Single	8JZP	C5A anaphylatoxin	8JZP-C5a₁-C5A anaphylatoxin-Go/β1/γ2
10.53	Single	8UGW	PubChem 3086599	8UGW-A_2A-PubChem 3086599
10.53	Single	8X16	Piclidenoson	8X16-A_3A-Piclidenoson-Gi1/β1/γ2
10.53	Single	8XBI	S3E-LysoPS	8XBI-GPR34-S3E-LysoPS
10.53	Single	8XIP	Pasireotide	8XIP-SST1-Pasireotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
10.53	Single	8YH6	Namodenoson	8YH6-A_3A-Namodenoson-Gi1/β1/γ2
10.53	Single	9AST	Lymphotactin	9AST-XCR1-Lymphotactin-Gi1/β1/γ2
10.53	Consensus	cyslt1_off	Orthosteric Ligand	6RZ5-CysLT₁-Zafirlukast-Na 6RZ4-CysLT₁-Pranlukast-Na
10.53	Consensus	nk2_on_gp	Orthosteric Ligand	7XWO-NK₂-Neurokinin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
10.53	Consensus	npy1_off	Orthosteric Ligand	5ZBH-Y₁-BMS-193885 5ZBQ-Y₁-UR-MK-299
10.53	Consensus	p2y12_on	Orthosteric Ligand	7XXI-P2Y₁₂-2MeSADP-Gi2/β1/γ2
10.34	Single	6LMK	Glucagon	6LMK-Glucagon-Glucagon-Gs/β1/γ2
10.34	Single	6LML	Glucagon	6LML-Glucagon-Glucagon-Gi1/β1/γ1
10.34	Single	6NBH	Long-Acting PTH Analog	6NBH-PTH1-Long-Acting PTH Analog-Gs/β1/γ2
10.34	Single	6UUS	Adrenomedullin	6UUS-CT Like (AM2)-Adrenomedullin-Gs/β1/γ2; RAMP3
10.34	Single	6WZG	Secretin	6WZG-Secretin-Secretin-Gs/β1/γ2
10.34	Single	7D68	GLP-2	7D68-GLP-2-GLP-2-Gs/β1/γ2
10.34	Single	7TS0	Urocortin	7TS0-CRF₂-Urocortin-chim(NtGi1L-Go)/β1/γ2
10.34	Single	7VGX	Neuropeptide-Y	7VGX-Y₁-Neuropeptide-Y-Gi1/β1/γ2
10.34	Single	7VVJ	PTHrP(1-36)	7VVJ-PTH1-PTHrP(1-36)-Gs/β1/γ2
10.34	Single	7VVL	PTH	7VVL-PTH1-PTH-Gs/β1/γ2
10.34	Single	8HAF	PTHrP(1-36)	8HAF-PTH1-PTHrP(1-36)-chim(NtGi1-Gs)/β1/γ2
10.34	Single	8WWN	MCH	8WWN-MCH1-MCH-Gi1/β1/γ2
10.34	Single	8Y52	BA1	8Y52-BB₃-BA1-chim(NtGi1-Gs-CtGq)/β1/γ2
10.00	Single	3VW7	Vorapaxar; Na	3VW7-PAR1-Vorapaxar; Na
10.00	Single	4N4W	SANT-1	4N4W-SMO-SANT-1
10.00	Single	6AK3	Dinoprostone IPGE2	6AK3-EP₃-Dinoprostone IPGE2
10.00	Single	6C1R	PMX53	6C1R-C5a₁-PMX53-Avacopan; Na
10.00	Single	6KPG	AM841	6KPG-CB₁-AM841-Gi1/β1/γ2
10.00	Single	6MXT	Salmeterol	6MXT-β₂-Salmeterol
10.00	Single	6W2Y	PubChem 23727970	6W2Y-GABAB1; GABAB1-PubChem 5311042-PubChem 23727970
10.00	Single	6XOX	Orforglipron	6XOX-GLP-1-Orforglipron-chim(NtGi1-Gs)/β1/γ2
10.00	Single	7DH5	Mirabegron	7DH5-β₃-Mirabegron-Gs/β1/γ2
10.00	Single	7EVY	Siponimod	7EVY-S1P₁-Siponimod-Gi1/β1/γ2
10.00	Single	7EW2	Fingolimod	7EW2-S1P₃-Fingolimod-Gi1/β1/γ2
10.00	Single	7F55	Bremelanotide	7F55-MC₄-Bremelanotide-Gs/β1/γ2
10.00	Single	7KNU	Calcitonin gene-related peptide-1	7KNU-CT Like-Calcitonin gene-related peptide-1-RAMP1
10.00	Single	7RBT	Tirzepatide	7RBT-GIP-Tirzepatide-PubChem 163183774-chim(NtGi1-Gs)/β1/γ2
10.00	Single	7T6B	S1P	7T6B-S1P₂-S1P-chim(NtGi1L-G13)/β1/γ2
10.00	Single	7T9M	CS-17 Antibody	7T9M-TSH-CS-17 Antibody
10.00	Single	7WQ4	Galanin	7WQ4-GAL₂-Galanin-chim(NtGi1-Gs-CtGq)/β1/γ2
10.00	Single	7XXI	2MeSADP	7XXI-P2Y₁₂-2MeSADP-Gi2/β1/γ2
10.00	Single	8GCP	PGE2	8GCP-EP₄-PGE2-Gi1/β1/γ2
10.00	Single	8IA8	E7 peptide	8IA8-C3a_B-E7 peptide-Gi1/β1/γ2
10.00	Single	8ID9	Eicosapentaenoic acid	8ID9-FFA4-Eicosapentaenoic acid-Gi1/β1/γ2
10.00	Single	8IYW	GSK256073	8IYW-HCA₂-GSK256073-Go/β1/γ2
10.00	Single	8JWY	2-118	8JWY-A_2A-2-118
10.00	Single	8TLM	Anti-murine CCR8 antibody	8TLM-CCR8-Anti-murine CCR8 antibody
10.00	Single	8W1V	PubChem 171716265	8W1V-β₂-PubChem 171716265
10.00	Single	8X8N	Octreotide	8X8N-SST5-Octreotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
10.00	Single	8XQN	Cholesterol	8XQN-TAS2R14-Cholesterol-Aristolochic acid A-Gi1/β1/γ1
10.00	Single	8XQS	Cholesterol	8XQS-TAS2R14-Cholesterol-Flufenamic acid-Gi1/β1/γ1
10.00	Single	8Y63	C20:0 Ceramide	8Y63-FPR2-ALX-C20:0 Ceramide-Gi1/β1/γ2
10.00	Single	8ZJE	TAK-448	8ZJE-Kiss1-TAK-448-chim(NtGi1-Gq)/β1/γ1
10.00	Single	9GYO	P395	9GYO-GPBA-P395-chim(NtGi1-Gs)/β1/γ2
10.00	Consensus	bb2_on	Orthosteric Ligand	7W40-BB₂-Bombesin-chim(NtGi1L-Gq)/β1/γ2 7W3Z-BB₂-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/β1/γ2
10.00	Consensus	bb2_on_gp	Orthosteric Ligand	7W40-BB₂-Bombesin-chim(NtGi1L-Gq)/β1/γ2 7W3Z-BB₂-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/β1/γ2
10.00	Consensus	beta3_on	Orthosteric Ligand	7DH5-β₃-Mirabegron-Gs/β1/γ2 7XJH-β₃-Isoproterenol-Gs/β1/γ2 7XJI-β₃-Solabegron-Gs/β1/γ2
10.00	Consensus	beta3_on_gp	Orthosteric Ligand	7DH5-β₃-Mirabegron-Gs/β1/γ2 7XJH-β₃-Isoproterenol-Gs/β1/γ2 7XJI-β₃-Solabegron-Gs/β1/γ2
10.00	Consensus	bombesin_on	Orthosteric Ligand	bb2_on
10.00	Consensus	bombesin_on_gp	Orthosteric Ligand	bb2_on_gp
10.00	Consensus	c3a_on	Orthosteric Ligand	8HK2-C3a_B-C3a anaphylatoxin-Gi1/β1/γ2 8IA8-C3a_B-E7 peptide-Gi1/β1/γ2
10.00	Consensus	cannabinoid_off	Orthosteric Ligand	cb2_off cb1_off
10.00	Consensus	ccr8_on	Orthosteric Ligand	8KFX-CCR8-LMD-009-Gi1/β1/γ2 8KFY-CCR8-ZK-756326-Gi1/β1/γ2 8U1U-CCR8-CCL1-Gi1/β1/γ2
10.00	Consensus	gi_p2y	Orthosteric Ligand	7XXI-P2Y₁₂-2MeSADP-Gi2/β1/γ2
10.00	Consensus	gq_bombesin	Orthosteric Ligand	7W40-BB₂-Bombesin-chim(NtGi1L-Gq)/β1/γ2 7W3Z-BB₂-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/β1/γ2
10.00	Consensus	leukotriene_off	Orthosteric Ligand	blt_off cyslt_off
10.00	Consensus	p2y12_on_gp	Orthosteric Ligand	7XXI-P2Y₁₂-2MeSADP-Gi2/β1/γ2
10.00	Consensus	s1p1_on	Orthosteric Ligand	7VIE-S1P₁-S1P-Gi1/β1/γ2 7VIF-S1P₁-S-FTY720-P-Gi1/β1/γ2 7VIG-S1P₁-CBP-307-Gi1/β1/γ2 7EVY-S1P₁-Siponimod-Gi1/β1/γ2 7EVZ-S1P₁-Cenerimod-Gi1/β1/γ2 7EW0-S1P₁-Ozanimod-Gi1/β1/γ2 7EW7-S1P₁-SEW2871-Gi1/β1/γ2
10.00	Consensus	s1p1_on_gp	Orthosteric Ligand	7VIE-S1P₁-S1P-Gi1/β1/γ2 7VIF-S1P₁-S-FTY720-P-Gi1/β1/γ2 7VIG-S1P₁-CBP-307-Gi1/β1/γ2 7EVY-S1P₁-Siponimod-Gi1/β1/γ2 7EVZ-S1P₁-Cenerimod-Gi1/β1/γ2 7EW0-S1P₁-Ozanimod-Gi1/β1/γ2 7EW7-S1P₁-SEW2871-Gi1/β1/γ2
9.68	Single	6LPB	PACAP	6LPB-PAC₁-PACAP-Gs/β1/γ1
9.68	Single	8FLS	Abaloparatide	8FLS-PTH1-Abaloparatide-Gs/β1/γ2
9.68	Single	8FLU	Long-Acting PTH	8FLU-PTH1-Long-Acting PTH-Gs/β1/γ2
9.52	Single	4NC3	Ergotamine	4NC3-5-HT_2B-Ergotamine
9.52	Single	6BQG	Ergotamine	6BQG-5-HT_2C-Ergotamine
9.52	Single	7CX4	Evatanepag	7CX4-EP₂-Evatanepag-Gs/β1/γ2
9.52	Single	7D7M	Dinoprostone	7D7M-EP₄-Dinoprostone-Gs/β1/γ1
9.52	Single	7EVZ	Cenerimod	7EVZ-S1P₁-Cenerimod-Gi1/β1/γ2
9.52	Single	7MBY	Cholecystokinin-8	7MBY-CCK_A-Cholecystokinin-8-chim(NtGi1L-Gs-CtGq)/β1/γ2
9.52	Single	7PIU	Setmelanotide	7PIU-MC₄-Setmelanotide-Gs/β1/γ2
9.52	Single	7QVM	Oxytocin	7QVM-OT-Oxytocin-chim(NtGi1-Go-CtGq)/β1/γ2
9.52	Single	7VVN	PTH	7VVN-PTH1-PTH-Gs/β1/γ2
9.52	Single	7WVV	fMLFII	7WVV-FPR2-ALX-fMLFII-Gi2/β1/γ2
9.52	Single	7X8R	BOC5	7X8R-GLP-1-BOC5-Gs/β1/γ2
9.52	Single	7XJI	Solabegron	7XJI-β₃-Solabegron-Gs/β1/γ2
9.52	Single	7XK2	MK6892	7XK2-HCA₂-MK6892-Gi1/β1/γ2
9.52	Single	8HN1	Toxin AdTx1	8HN1-Alpha1A-Toxin AdTx1
9.52	Single	8ID8	TUG-891	8ID8-FFA4-TUG-891-Gi1/β1/γ2
9.52	Single	8IJD	MK6892	8IJD-HCA₂-MK6892-Gi1/β1/γ2
9.52	Single	8IUL	Latanoprost	8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/β1/γ2
9.52	Single	8WRZ	PubChem 102336704	8WRZ-CB₁-PubChem 102336704-Arrestin2
9.52	Single	8XGS	Metastin	8XGS-Kiss1-Metastin-chim(NtGi1-Gq)/β1/γ2
9.52	Consensus	class-a_on	Orthosteric Ligand	sensory_on alicarboxylic_on amine_on lipid_on nucleotide_on peptide_on protein_on
9.52	Consensus	fp-alpha_on	Orthosteric Ligand	8IUK-FP-alpha-PGF2-α-chim(NtGi1-Gs-CtGq)/β1/γ2 8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/β1/γ2 8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/β1/γ2
9.52	Consensus	fp-alpha_on_gp	Orthosteric Ligand	8IUK-FP-alpha-PGF2-α-chim(NtGi1-Gs-CtGq)/β1/γ2 8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/β1/γ2 8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/β1/γ2
9.52	Consensus	gi_s1p	Orthosteric Ligand	7VIE-S1P₁-S1P-Gi1/β1/γ2 7EW3-S1P₃-S1P-Gi1/β1/γ2 7EVY-S1P₁-Siponimod-Gi1/β1/γ2 7EW1-S1P₅-Siponimod-Gi1/β1/γ2 7VIF-S1P₁-S-FTY720-P-Gi1/β1/γ2 7VIG-S1P₁-CBP-307-Gi1/β1/γ2 7EVZ-S1P₁-Cenerimod-Gi1/β1/γ2 7EW4-S1P₃-CYM5541-Gi1/β1/γ2 7EW2-S1P₃-Fingolimod-Gi1/β1/γ2 7EW0-S1P₁-Ozanimod-Gi1/β1/γ2 7EW7-S1P₁-SEW2871-Gi1/β1/γ2
9.52	Consensus	nk2_on	Orthosteric Ligand	7XWO-NK₂-Neurokinin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
9.52	Consensus	nucleotide_on_gp	Orthosteric Ligand	adenosine_on_gp p2y_on_gp
9.52	Consensus	peptide_off	Orthosteric Ligand	cck_off angiotensin_off bombesin_off endothelin_off ghrelin_off npy_off opioid_off orexin_off somatostatin_off tachykinin_off vasop-oxy_off neurotensin_off
9.52	Consensus	prostanoid_off	Orthosteric Ligand	ep_off dp_off
9.38	Single	6WPW	Glucagon derivative ZP3780	6WPW-Glucagon-Glucagon derivative ZP3780-Gs/β1/γ2
9.38	Single	7V35	Peptide-20	7V35-Glucagon-Peptide-20-Gs/β1/γ2
9.38	Single	7VVM	PTH	7VVM-PTH1-PTH-Gs/β1/γ2
9.38	Single	8JIP	MEDI0382	8JIP-GLP-1-MEDI0382-chim(NtGi1-Gs)/β1/γ2
9.38	Single	9JR2	PTH	9JR2-PTH1-PTH-chim(NtGi1L-Gs-CtGq)/β1/γ2
9.09	Single	4UG2	CGS21680	4UG2-A_2A-CGS21680
9.09	Single	6C1Q	PMX53	6C1Q-C5a₁-PMX53-NDT9513727
9.09	Single	6G79	Donitriptan	6G79-5-HT_1B-Donitriptan-Go/β1/γ2
9.09	Single	6O3C	Cholesterol	6O3C-SMO-SAG21k-Cholesterol
9.09	Single	6W2Y	PubChem 23727970	6W2Y-GABAB1; GABAB1-PubChem 5311042-PubChem 23727970
9.09	Single	6XBJ	Cholesterol	6XBJ-SMO-Cholesterol-Gi1/β1/γ2
9.09	Single	7AUE	Setmelanotide	7AUE-MC₄-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2
9.09	Single	7CX2	PGE2	7CX2-EP₂-PGE2-Gs/β1/γ2
9.09	Single	7FIG	hCG	7FIG-LH-hCG-chim(NtGi1L-Gs)/β1/γ2
9.09	Single	7RMG	Substance-P	7RMG-NK₁-Substance-P-chim(Gs-CtGq)/β1/γ2
9.09	Single	7SK9	CCX662	7SK9-ACKR3-CCX662
9.09	Single	7T11	Octreotide	7T11-SST2-Octreotide-Gi3/β1/γ2
9.09	Single	7UTZ	TR1402	7UTZ-TSH-TR1402-PubChem 644078-Gs/β1/γ2
9.09	Single	7X8S	WB4-24	7X8S-GLP-1-WB4-24-Gs/β1/γ2
9.09	Single	7XN9	L-054,522	7XN9-SST2-L-054,522
9.09	Single	7XW5	TSH	7XW5-TSH-TSH-ML109-Gs/β1/γ2
9.09	Single	7XY6	BAY 60-6583	7XY6-A_2B-BAY 60-6583-chim(NtGi1-Gs)/β1/γ2
9.09	Single	7Y1F	Dynorphin	7Y1F-κ-Dynorphin-Gi1/β1/γ2
9.09	Single	7Y36	Teriparatide	7Y36-PTH1-Teriparatide-Gs/β1/γ2
9.09	Single	7ZI0	Cholesterol	7ZI0-SMO-SAG-Cholesterol
9.09	Single	8FLQ	PTH	8FLQ-PTH1-PTH-Gs/β1/γ2
9.09	Single	8GDA	L902688	8GDA-EP₄-L902688-Gs/β1/γ2
9.09	Single	8H4I	Doconexent	8H4I-FFA4-Doconexent-chim(NtGi1-Gs)/β1/γ2
9.09	Single	8IQ4	Carboprost	8IQ4-FP-alpha-Carboprost-chim(NtGi1-Gs-CtGq)/β1/γ2
9.09	Single	8IUM	Tafluprost acid	8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/β1/γ2
9.09	Single	8JIT	MEDI0382	8JIT-Glucagon-MEDI0382-Gs/β1/γ2
9.09	Single	8JIU	SAR425899	8JIU-Glucagon-SAR425899-Gs/β1/γ2
9.09	Single	8WCB	Cyclohexylammonium Ion	8WCB-TA1-Cyclohexylammonium Ion-chim(NtGi1-Gs-CtGq)/β1/γ2
9.09	Single	8WCC	Cyclohexylammonium Ion	8WCC-TA1-Cyclohexylammonium Ion
9.09	Single	8XOF	Lys05	8XOF-GPR30-Lys05-chim(NtGi1-Gs-CtGq)/β1/γ2
9.09	Single	8XQL	Cholesterol	8XQL-TAS2R14-Cholesterol-Aristolochic acid A-Gt3/β1/γ1
9.09	Single	8XQO	Cholesterol	8XQO-TAS2R14-Cholesterol-Aristolochic acid A-Gi1/β1/γ1
9.09	Single	8Z74	Agonistic antibody	8Z74-Apelin-Agonistic antibody
9.09	Single	9ERX	D9-THC analog	9ERX-CB₁-D9-THC analog-Gi1/β1/γ2
9.09	Single	9JR3	PTH	9JR3-PTH1-PTH-chim(NtGi1L-Gs-CtGq)/β1/γ2
9.09	Consensus	cxcr3_on	Orthosteric Ligand	8HNK-CXCR3-CXCL11-Gi1/β1/γ2 8HNL-CXCR3-PS372424-Gi1/β1/γ2
9.09	Consensus	dop_on	Orthosteric Ligand	8F7S-δ-Deltorphin-Gi1/β1/γ2
9.09	Consensus	kiss1_on	Orthosteric Ligand	8ZJD-Kiss1-Kisspeptin-10-chim(NtGi1-Gq)/β1/γ1
9.09	Consensus	kisspeptin_on	Orthosteric Ligand	kiss1_on
9.09	Consensus	nmur1_on	Orthosteric Ligand	7W53-NMUR1-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
9.09	Consensus	ox2_on	Orthosteric Ligand	7L1V-OX₂-PubChem 155491009-chim(NtGi1-Gs-CtGq)/β1/γ2 7SQO-OX₂-TAK-925-Gi1/β1/γ2 7L1U-OX₂-Orexin-chim(NtGi1-Gs-CtGq)/β1/γ2
9.09	Consensus	ox2_on_gp	Orthosteric Ligand	7L1V-OX₂-PubChem 155491009-chim(NtGi1-Gs-CtGq)/β1/γ2 7SQO-OX₂-TAK-925-Gi1/β1/γ2 7L1U-OX₂-Orexin-chim(NtGi1-Gs-CtGq)/β1/γ2
9.09	Consensus	s1p_on	Orthosteric Ligand	s1p1_on s1p3_on s1p5_on
9.09	Consensus	s1p_on_gp	Orthosteric Ligand	s1p1_on_gp s1p3_on_gp s1p5_on_gp
9.09	Consensus	sst2_on	Orthosteric Ligand	7WIC-SST2-Somatostatin-14-Gi1/β1/γ2 7WIG-SST2-L-054,264-Gi1/β1/γ2 7YAE-SST2-Octreotide-Gi1/β1/γ2 7YAC-SST2-Paltusotine-Gi1/β1/γ2
9.09	Consensus	sst2_on_gp	Orthosteric Ligand	7WIC-SST2-Somatostatin-14-Gi1/β1/γ2 7WIG-SST2-L-054,264-Gi1/β1/γ2 7YAE-SST2-Octreotide-Gi1/β1/γ2 7YAC-SST2-Paltusotine-Gi1/β1/γ2
8.70	Single	4IAR	Ergotamine	4IAR-5-HT_1B-Ergotamine
8.70	Single	4IB4	Ergotamine	4IB4-5-HT_2B-Ergotamine
8.70	Single	4XT1	Fractalkine	4XT1-US28-Fractalkine
8.70	Single	6WIV	PubChem 52923113; PubChem 52924645	6WIV-GABA_B1, GABA_B2-PubChem 52923113; PubChem 52924645
8.70	Single	6X19	CHU-128	6X19-GLP-1-CHU-128-Gs/β1/γ2
8.70	Single	7CX3	Taprenepag	7CX3-EP₂-Taprenepag-Gs/β1/γ2
8.70	Single	7QA8	Peptide	7QA8-STE2-Peptide
8.70	Single	7QA8	Peptide	7QA8-STE2-Peptide
8.70	Single	7TD4	Siponimod	7TD4-S1P₁-Siponimod-Gi1/β1/γ2
8.70	Single	7W53	Neuromedin-U-25	7W53-NMUR1-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
8.70	Single	7WVW	fMYFINILTL	7WVW-FPR2-ALX-fMYFINILTL-Gi2/β1/γ2
8.70	Single	7XMR	Somatostatin-14	7XMR-SST2-Somatostatin-14-Gi1/β1/γ2
8.70	Single	8G59	TUG-891	8G59-FFA4-TUG-891-chim(Gi1-CtGq)/β1/γ2
8.70	Single	8GHV	AMG315	8GHV-CB₁-AMG315-Gi1/β1/γ2
8.70	Single	8INR	Alpha-MSH	8INR-MC₅-α-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
8.70	Single	8J6R	MK6892	8J6R-HCA₂-MK6892-Gi1/β1/γ2
8.70	Single	8WDT	photoNECA	8WDT-A_2A-photoNECA
8.70	Single	8WZ2	Orexigenic Neuropeptide QRFP	8WZ2-QRFP-Orexigenic Neuropeptide QRFP-chim(NtGi1L-Gs-CtGq)/β1/γ2
8.70	Single	8XBH	S3E-LysoPS	8XBH-GPR34-S3E-LysoPS-Gi1/β1/γ2
8.70	Single	8ZJD	Kisspeptin-10	8ZJD-Kiss1-Kisspeptin-10-chim(NtGi1-Gq)/β1/γ1
8.70	Consensus	gi_opioid	Orthosteric Ligand	8F7R-μ-Endomorphin-Gi1/β1/γ2 8EF5-μ-Fentanyl-Gi1/β1/γ2 7SCG-μ-FH210-Gi1/β1/γ2 7T2H-μ-Lofentanil-Gi1/β1/γ2 7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2 8DZP-κ-momSalB-Gi1/β1/γ2 8EF6-μ-Morphine-Gi1/β1/γ2 8F7X-NOP-Nociceptin-Gi1/β1/γ2 8EFB-μ-Oliceridine-Gi1/β1/γ2 7U2L-μ-PubChem 163201242-Gi1/β1/γ2 8EFO-μ-PZM21-Gi1/β1/γ2 8EFL-μ-SR17018-Gi1/β1/γ2 8F7Q-μ-β-Endorphin-Gi1/β1/γ2 7U2K-μ-C6-guano-Gi1/β1/γ2 8EFQ-μ-Damgo-Gi1/β1/γ2 8F7S-δ-Deltorphin-Gi1/β1/γ2 8F7W-κ-Dynorphin-Gi1/β1/γ2
8.70	Consensus	gq_kisspeptin	Orthosteric Ligand	8ZJD-Kiss1-Kisspeptin-10-chim(NtGi1-Gq)/β1/γ1
8.70	Consensus	kiss1_on_gp	Orthosteric Ligand	8ZJD-Kiss1-Kisspeptin-10-chim(NtGi1-Gq)/β1/γ1
8.70	Consensus	kisspeptin_on_gp	Orthosteric Ligand	kiss1_on_gp
8.70	Consensus	mop_off	Orthosteric Ligand	4DKL-μ-β-Funaltrexamine 8QOT-μ-Nanobody-E 7UL4-μ-Alvimopan
8.70	Consensus	nmur1_on_gp	Orthosteric Ligand	7W53-NMUR1-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
8.33	Single	5L7D	Cholesterol	5L7D-SMO-Cholesterol
8.33	Single	5MZJ	Theophylline	5MZJ-A_2A-Theophylline-Na
8.33	Single	6WHC	Glu16 analog of GCG	6WHC-Glucagon-Glu16 analog of GCG-Gs/β1/γ2
8.33	Single	7CUM	Phospholipid	7CUM-GABA_B1, GABA_B2-CGP54626-Phospholipid
8.33	Single	7CUM	Phospholipid	7CUM-GABA_B1, GABA_B2-CGP54626-Phospholipid
8.33	Single	7E14	Orforglipron	7E14-GLP-1-Orforglipron-PubChem 156022738-Gs/β1/γ2
8.33	Single	7F16	TIP39	7F16-PTH2-TIP39-Gs/β1/γ2
8.33	Single	7RMI	Substance-P	7RMI-NK₁-Substance-P-chim(Gs-CtGq)/β1/γ2
8.33	Single	7T9I	TSH	7T9I-TSH-TSH-Gs/β1/γ2
8.33	Single	7V68	PubChem 57664406	7V68-M₄-Iperoxo-PubChem 57664406-Gi1/β1/γ2
8.33	Single	7XKD	Beta-Hydroxyandrosterone	7XKD-ADGRG2-β-Hydroxyandrosterone-Gs/β1/γ2
8.33	Single	7XKE	Beta-Hydroxyandrosterone	7XKE-ADGRG2-β-Hydroxyandrosterone-chim(NtGi1-Gs)/β1/γ2
8.33	Single	8I2G	Glycoprotein hormones alpha chain	8I2G-FSH-Glycoprotein hormones α chain-Compound 716340-Gs/β1/γ2
8.33	Single	8IEB	A1LYA	8IEB-GPR156-A1LYA
8.33	Single	8IOC	Gamma-MSH	8IOC-MC₃-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
8.33	Single	8JBH	Substance-P	8JBH-NK₃-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
8.33	Single	8KH5	Lysophosphatidylserine	8KH5-GPR174-Lysophosphatidylserine-Gs/β1/γ2
8.33	Single	8PWN	Theophylline	8PWN-A_2A-Theophylline
8.33	Single	8SG1	Chemerin-9	8SG1-CML1-Chemerin-9-Gi1/β1/γ2
8.33	Single	8X9S	5alpha-DHT	8X9S-ADGRD1-5α-DHT-chim(NtGi1-Gs)/β1/γ2
8.33	Single	8XYD	Platelet Activating Factor	8XYD-PAF-Platelet Activating Factor-Gi1/β1/γ2
8.33	Single	9IV2	5alpha-DHT	9IV2-ADGRD1-5α-DHT-chim(NtGi1-Gs)/β1/γ2
8.33	Consensus	ccr8_on_gp	Orthosteric Ligand	8KFX-CCR8-LMD-009-Gi1/β1/γ2 8KFY-CCR8-ZK-756326-Gi1/β1/γ2 8U1U-CCR8-CCL1-Gi1/β1/γ2
8.33	Consensus	ghrelin_on	Orthosteric Ligand	7NA7-Ghrelin-Ghrelin-27-Gi1/β1/γ2 7F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/β1/γ2 7NA8-Ghrelin-PubChem 178024-Gi1/β1/γ2
8.33	Consensus	ghrelin_on_gp	Orthosteric Ligand	7NA7-Ghrelin-Ghrelin-27-Gi1/β1/γ2 7F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/β1/γ2 7NA8-Ghrelin-PubChem 178024-Gi1/β1/γ2
8.33	Consensus	s1p3_on_gp	Orthosteric Ligand	7EW3-S1P₃-S1P-Gi1/β1/γ2 7EW4-S1P₃-CYM5541-Gi1/β1/γ2 7EW2-S1P₃-Fingolimod-Gi1/β1/γ2
8.00	Single	6PT2	KGCHM07	6PT2-δ-KGCHM07
8.00	Single	6VN7	PACAP	6VN7-VPAC₁-PACAP-Gs/β1/γ2
8.00	Single	7F4D	Alpha-MSH	7F4D-MC₁-α-MSH-chim(NtGi1-Gs)/β1/γ2
8.00	Single	7T6T	fMLFII	7T6T-FPR1-ALX-fMLFII-Gi1/β1/γ2
8.00	Single	8K6M	Neuropeptide-Y	8K6M-Y₁-Neuropeptide-Y-Gi2/β1/γ1
8.00	Single	8XGU	TAK448	8XGU-Kiss1-TAK448-Gi1/β1/γ2
8.00	Single	8XIR	Pasireotide	8XIR-SST3-Pasireotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
8.00	Consensus	gi_somatostatin	Orthosteric Ligand	7WIC-SST2-Somatostatin-14-Gi1/β1/γ2 7XMS-SST4-Somatostatin-14-Gi1/β1/γ2 8X8L-SST5-Cortistatin-chim(NtGi1-Gs-CtGi1)/β1/γ2 7XMT-SST4-J-2156-Gi1/β1/γ2 7WIG-SST2-L-054,264-Gi1/β1/γ2 8X8N-SST5-Octreotide-chim(NtGi1-Gs-CtGi1)/β1/γ2 7YAE-SST2-Octreotide-Gi1/β1/γ2 7YAC-SST2-Paltusotine-Gi1/β1/γ2
8.00	Consensus	gs_class-a	Orthosteric Ligand	gs_peptide gs_nucleotide gs_amine
8.00	Consensus	mc3_on	Orthosteric Ligand	8IOC-MC₃-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
8.00	Consensus	mc3_on_gp	Orthosteric Ligand	8IOC-MC₃-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
8.00	Consensus	npy1_on	Orthosteric Ligand	8K6M-Y₁-Neuropeptide-Y-Gi2/β1/γ1
8.00	Consensus	npy1_on_gp	Orthosteric Ligand	8K6M-Y₁-Neuropeptide-Y-Gi2/β1/γ1
8.00	Consensus	somatostatin_on	Orthosteric Ligand	sst2_on sst4_on sst5_on
8.00	Consensus	somatostatin_on_gp	Orthosteric Ligand	sst2_on_gp sst4_on_gp sst5_on_gp
7.69	Single	6NIY	Adrenomedullin	6NIY-CT-Adrenomedullin-Gs/β1/γ2
7.69	Single	6OT0	25(S)-Epoxycholesterol	6OT0-SMO-25(S)-Epoxycholesterol-Gi1/β1/γ2
7.69	Single	7F4H	Afamelanotide	7F4H-MC₁-Afamelanotide-chim(NtGi1-Gs)/β1/γ2
7.69	Single	7V9M	Somatoliberin	7V9M-GHRH (SV1)-Somatoliberin-Gs/β1/γ2
7.69	Single	7VDM	Substance-P	7VDM-MRGPRX2-Substance-P-Gi1/β1/γ2
7.69	Single	8A2O	Theophylline	8A2O-A_2A-Theophylline-Na
7.69	Single	8IED	A1LYA	8IED-GPR156-A1LYA-Go/β1/γ2
7.69	Single	8J6I	MK6892	8J6I-HCA₂-MK6892-Gi1/β1/γ2
7.41	Single	7QBI	Alpha-factor mating pheromone	7QBI-STE2-α-factor mating pheromone
7.41	Single	8XGO	TAK448	8XGO-Kiss1-TAK448-chim(NtGi1-Gq)/β1/γ2
7.41	Consensus	mc1_on	Orthosteric Ligand	7F4H-MC₁-Afamelanotide-chim(NtGi1-Gs)/β1/γ2 7F4D-MC₁-α-MSH-chim(NtGi1-Gs)/β1/γ2 7F4I-MC₁-SHU9119-chim(NtGi1-Gs)/β1/γ2
7.41	Consensus	mc1_on_gp	Orthosteric Ligand	7F4H-MC₁-Afamelanotide-chim(NtGi1-Gs)/β1/γ2 7F4D-MC₁-α-MSH-chim(NtGi1-Gs)/β1/γ2 7F4I-MC₁-SHU9119-chim(NtGi1-Gs)/β1/γ2
7.14	Single	2J4Y	11-cis-Retinal	2J4Y-Rhodopsin-11-cis-Retinal
7.14	Single	3OE6	IT1t	3OE6-CXCR4-IT1t
7.14	Single	5WKT	Octyl-Beta-D-Glucopyranoside	5WKT-Rhodopsin-Octyl-β-D-Glucopyranoside-Gt(CT)
7.14	Single	6FK9	PubChem 132473036	6FK9-Rhodopsin-PubChem 132473036
7.14	Single	6ME5	Agomelatine	6ME5-MT₁-Agomelatine
7.14	Single	6OIK	LY2119620	6OIK-M₂-Iperoxo-LY2119620-chim(NtGi1-Go)/β1/γ2
7.14	Single	7D3S	Secretin	7D3S-Secretin-Secretin-Gs/β1/γ2
7.14	Single	7D77	Hydrocortisone	7D77-ADGRG3-Hydrocortisone-Go/β1/γ2
7.14	Single	7F23	Dopamine	7F23-D₁-Dopamine-GDP-Gs/β1/γ2
7.14	Single	7F61	Cholesterol	7F61-H₃-PF-03654746-Cholesterol
7.14	Single	7MT8	All-trans-Retinal	7MT8-Rhodopsin-All-trans-Retinal-GRK1
7.14	Single	7MT9	All-trans-Retinal	7MT9-Rhodopsin-All-trans-Retinal-GRK1
7.14	Single	7MTA	All-trans-Retinal	7MTA-Rhodopsin-All-trans-Retinal-GRK1
7.14	Single	7QBI	Alpha-factor mating pheromone	7QBI-STE2-α-factor mating pheromone
7.14	Single	7WC5	Psilocin	7WC5-5-HT_2A-Psilocin
7.14	Single	8F76	Propanoic acid	8F76-OR51E2-Propanoic acid-Gs/β1/γ2
7.14	Single	8J6Q	Beta-Hydroxybutyrate	8J6Q-HCA₂-β-Hydroxybutyrate-Compound 9n-Gi1/β1/γ2
7.14	Single	8WC6	2-Phenylethylamine	8WC6-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/β1/γ2
7.14	Single	9IV1	5alpha-DHT	9IV1-ADGRD1-5α-DHT-chim(NtGi1-Gs)/β1/γ2
6.90	Single	6P9X	Corticoliberin	6P9X-CRF₁-Corticoliberin-Gs/β1/γ2
6.90	Single	7AD3	Alpha-factor mating pheromone	7AD3-STE2-α-factor mating pheromone-Gi1/STE4/γ2
6.90	Single	7QBC	Alpha-factor mating pheromone	7QBC-STE2-α-factor mating pheromone
6.67	Single	3OE9	IT1t	3OE9-CXCR4-IT1t
6.67	Single	3VGA	ZM-241385	3VGA-A_2A-ZM-241385-Antibody
6.67	Single	6FK6	PubChem 132473033	6FK6-Rhodopsin-PubChem 132473033
6.67	Single	6PB1	Urocortin	6PB1-CRF₂-Urocortin-chim(NtGi1-Gs)/β1/γ2
6.67	Single	6PGS	Geraniol	6PGS-Rhodopsin-Geraniol-Gt(CT)
6.67	Single	6PH7	Nerol	6PH7-Rhodopsin-Nerol-Gt(CT)
6.67	Single	6QNO	All-trans-Retinal	6QNO-Rhodopsin-All-trans-Retinal-Gi1/β1/γ1
6.67	Single	7D76	Beclomethasone	7D76-ADGRG3-Beclomethasone-Go/β1/γ2
6.67	Single	7QBC	Alpha-factor mating pheromone	7QBC-STE2-α-factor mating pheromone
6.67	Single	7S8N	R-Zinc-3573	7S8N-MRGPRX2-R-Zinc-3573-chim(NtGi2L-Gs-CtGq)/β1/γ2
6.67	Single	7S8O	R-Zinc-3573	7S8O-MRGPRX2-R-Zinc-3573-Gi1/β1/γ2
6.67	Single	7XKF	Beta-Hydroxyandrosterone	7XKF-ADGRG2-β-Hydroxyandrosterone-Gs/β1/γ2
6.67	Single	7XT9	Serotonin	7XT9-5-HT₄-Serotonin-Gs/β1/γ2
6.67	Single	7XTA	Serotonin	7XTA-5-HT₄-Serotonin-Gi1/β1/γ2
6.67	Single	8FLT	M-PTH(1-14)	8FLT-PTH1-M-PTH(1-14)-Gs/β1/γ2
6.67	Single	8H2G	Niacin	8H2G-HCA₂-Niacin-Gi1/β1/γ2
6.67	Single	8JLO	Ulotaront	8JLO-TA1-Ulotaront-Gs/β1/γ2
6.67	Single	8K5B	Niacin	8K5B-HCA₂-Niacin
6.67	Single	8RWH	StilSwitch2	8RWH-A_2A-StilSwitch2-Na
6.67	Single	8W89	PEA	8W89-TA1-PEA-chim(NtGi1L-Gs)/β1/γ2
6.67	Single	8ZSV	RO5263397	8ZSV-TA1-RO5263397-chim(NtGi1-Gs)/β1/γ2
6.67	Single	9EPQ	11,20-Ethanoretinal	9EPQ-Rhodopsin-11,20-Ethanoretinal-chim(Gi1-CtGq)/β1/γ2
6.67	Single	9IQT	Niacin	9IQT-HCA₂-Niacin-Gi1/β1/γ2
6.67	Single	9J5V	CpY	9J5V-LPA₁-CpY-Gi1/β1/γ2
6.67	Single	9L3Z	LRH7-C2	9L3Z-CML1-LRH7-C2
6.67	Consensus	5ht4_on	Orthosteric Ligand	7XTA-5-HT₄-Serotonin-Gi1/β1/γ2
6.67	Consensus	5ht4_on_gp	Orthosteric Ligand	7XTA-5-HT₄-Serotonin-Gi1/β1/γ2
6.45	Single	6PB0	Urocortin	6PB0-CRF₁-Urocortin-chim(NtGi1-Gs)/β1/γ2
6.25	Single	2X72	All-trans-Retinal	2X72-Rhodopsin-All-trans-Retinal-Gt(CT)
6.25	Single	3ODU	IT1t	3ODU-CXCR4-IT1t
6.25	Single	5OLH	Vipadenant	5OLH-A_2A-Vipadenant-Na
6.25	Single	5ZKQ	ABT-491	5ZKQ-PAF-ABT-491
6.25	Single	6D9H	Adenosine	6D9H-A₁-Adenosine-Gi2/β1/γ2
6.25	Single	6DS0	Ly266097	6DS0-5-HT_2B-Ly266097
6.25	Single	6FKB	PubChem 132473038	6FKB-Rhodopsin-PubChem 132473038
6.25	Single	6ME2	Ramelteon	6ME2-MT₁-Ramelteon
6.25	Single	6ME9	Ramelteon	6ME9-MT₂-Ramelteon
6.25	Single	6NWE	Octyl-Beta-D-Glucopyranoside	6NWE-Rhodopsin-Octyl-β-D-Glucopyranoside-Gt(CT)
6.25	Single	6OYA	All-trans-Retinal	6OYA-Rhodopsin-All-trans-Retinal-Gt/β1/γ1
6.25	Single	7F1O	Dopamine	7F1O-D₁-Dopamine-GDP; Mg-Gs/β1/γ2
6.25	Single	7LD4	Adenosine	7LD4-A₁-Adenosine-Gi2/β1/γ2
6.25	Single	7TUZ	7-alpha,25-dihydroxycholesterol	7TUZ-GPR183-7-α,25-dihydroxycholesterol-Gi1/β1/γ2
6.25	Single	7VIH	CBP-307	7VIH-S1P₁-CBP-307-Gi1/β1/γ2
6.25	Single	7W0M	PubChem 122701908	7W0M-Apelin-PubChem 122701908-Gi1/β1/γ2
6.25	Single	7XT8	Serotonin	7XT8-5-HT₄-Serotonin-Gs/β1/γ2
6.25	Single	8DU3	PubChem 105526064	8DU3-A_2A-PubChem 105526064
6.25	Single	8DWH	PubChem 139030531	8DWH-MRGPRX1-PubChem 139030531-chim(NtGi2L-Gs-CtGq)/β1/γ2
6.25	Single	8GNG	Istradefylline	8GNG-A_2A-Istradefylline
6.25	Single	8HDP	Adenosine	8HDP-A_2B-Adenosine-Gs/β1/γ2
6.25	Single	8JPP	Succinic acid	8JPP-Succinate-Succinic acid-chim(Gs-CtGq)/β1/γ1
6.25	Single	8JSO	AMPH	8JSO-TA1-AMPH-chim(NtGi1-Gs)/β1/γ2
6.25	Single	8RW4	AzoSwitch2	8RW4-A_2A-AzoSwitch2-Na
6.25	Single	8RWE	StilSwitch4	8RWE-A_2A-StilSwitch4-Na
6.25	Single	8U8F	Palmitic Acid	8U8F-GPR3-Palmitic Acid-Gs/β1/γ2
6.25	Single	8WC4	ZH8651	8WC4-TA1-ZH8651-chim(NtGi1-Gs)/β1/γ2
6.25	Single	8WCA	2-Phenylethylamine	8WCA-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/β1/γ2
6.25	Single	9AUC	Calcitonin gene-related peptide-1	9AUC-CT (AMY1)-Calcitonin gene-related peptide-1-Gs/β1/γ2; RAMP1
6.25	Single	9FUP	Istradefylline	9FUP-A_2A-Istradefylline-Na
6.25	Consensus	a1_on	Orthosteric Ligand	7LD4-A₁-Adenosine-Gi2/β1/γ2
6.25	Consensus	a1_on_gp	Orthosteric Ligand	7LD4-A₁-Adenosine-Gi2/β1/γ2
6.25	Consensus	paf_off	Orthosteric Ligand	5ZKQ-PAF-ABT-491
6.25	Consensus	rhodopsin_on_gp	Orthosteric Ligand	6OYA-Rhodopsin-All-trans-Retinal-Gt/β1/γ1
5.88	Single	1F88	11-cis-Retinal	1F88-Rhodopsin-11-cis-Retinal
5.88	Single	2YDO	Adenosine	2YDO-A_2A-Adenosine
5.88	Single	3REY	XAC	3REY-A_2A-XAC
5.88	Single	4N6H	Naltrindole	4N6H-δ-Naltrindole-Na
5.88	Single	4ZUD	Olmesartan	4ZUD-AT₁-Olmesartan
5.88	Single	5TE3	Octyl-Beta-D-Glucopyranoside	5TE3-Rhodopsin-Octyl-β-D-Glucopyranoside
5.88	Single	6FK8	PubChem 132473035	6FK8-Rhodopsin-PubChem 132473035
5.88	Single	6FKA	PubChem 132473037	6FKA-Rhodopsin-PubChem 132473037
5.88	Single	6ME3	2-Phenylmelatonin	6ME3-MT₁-2-Phenylmelatonin
5.88	Single	6ME4	2-Iodomelatonin	6ME4-MT₁-2-Iodomelatonin
5.88	Single	6MH8	ZM-241385	6MH8-A_2A-ZM-241385
5.88	Single	6PEL	Citronellol	6PEL-Rhodopsin-Citronellol-Gt(CT)
5.88	Single	6PS8	2-Phenylmelatonin	6PS8-MT₁-2-Phenylmelatonin
5.88	Single	6PT0	WIN 55212-2	6PT0-CB₂-WIN 55212-2-Gi1/β1/γ2
5.88	Single	6ZIN	SR48692	6ZIN-NTS₁-SR48692
5.88	Single	7BB6	AVP	7BB6-V₂-AVP-Gs/β1/γ2
5.88	Single	7CKW	Fenoldopam	7CKW-D₁-Fenoldopam-Gs/β1/γ2
5.88	Single	7CKZ	Dopamine	7CKZ-D₁-Dopamine-Mevidalen-Gs/β1/γ2
5.88	Single	7F0T	Dopamine	7F0T-D₁-Dopamine-Gs/β1/γ2
5.88	Single	7F1Z	Dopamine	7F1Z-D₁-Dopamine-GDP-Gs/β1/γ2
5.88	Single	7VUG	JNJ-63533054	7VUG-GPR139-JNJ-63533054-Gi1/β1/γ2
5.88	Single	8GUQ	Olorinab	8GUQ-CB₂-Olorinab-Gi1/β1/γ2
5.88	Single	8GUR	CP55,940	8GUR-CB₂-CP55,940-Gi1/β1/γ2
5.88	Single	8IHK	Acifran	8IHK-HCA₃-Acifran
5.88	Single	8JEI	3-nitro-4-(propylamino)benzoic acid	8JEI-HCAR3-3-nitro-4-(propylamino)benzoic acid-Gi1/β1/γ2
5.88	Single	8JIM	MMF	8JIM-HCA₂-MMF-Gi1/β1/γ2
5.88	Single	8JLK	Ulotaront	8JLK-TA1-Ulotaront-chim(NtGi1-Gs)/β1/γ2
5.88	Single	8JLQ	Fenoldopam	8JLQ-TA1-Fenoldopam-Gs/β1/γ2
5.88	Single	8K2W	AMG487	8K2W-CXCR3-AMG487
5.88	Single	8K4S	DCA-3P	8K4S-MRGPRX4-DCA-3P-chim(NtGi1L-Gs-CtGq)/β1/γ2
5.88	Single	8UHB	RO5256390	8UHB-TA1-RO5256390-Gs/β1/γ2
5.88	Single	8W88	SEP-363856	8W88-TA1-SEP-363856-Gs/β1/γ2
5.88	Single	8WC8	ZH8651	8WC8-TA1-ZH8651-chim(NtGi1-Gs)/β1/γ2
5.88	Single	8X7A	Treprostinil	8X7A-I2-Treprostinil-Gs/β1/γ2
5.88	Single	8Y45	ADL5859	8Y45-δ-ADL5859-Gi2/β1/γ2
5.88	Single	8ZPM	AMD070	8ZPM-CXCR4-AMD070-Cholesterol
5.88	Single	9JKQ	METH	9JKQ-TA1-METH-Gs/β1/γ2
5.88	Consensus	adenosine_on	Orthosteric Ligand	a1_on a2_on a3_on
5.88	Consensus	cxcr3_off	Orthosteric Ligand	8K2W-CXCR3-AMG487
5.88	Consensus	gi_adenosine	Orthosteric Ligand	7LD4-A₁-Adenosine-Gi2/β1/γ2 8X17-A_3A-Namodenoson-Gi1/β1/γ2 8X16-A_3A-Piclidenoson-Gi1/β1/γ2
5.88	Consensus	hca_on	Orthosteric Ligand	hca2_on
5.88	Consensus	opsins_off	Orthosteric Ligand	rhodopsin_off
5.88	Consensus	sensory_off	Orthosteric Ligand	opsins_off
5.56	Single	2Y01	Dobutamine	2Y01-β₁-Dobutamine
5.56	Single	4EJ4	Naltrindole	4EJ4-δ-Naltrindole
5.56	Single	4J4Q	Octyl Beta-D-Glucopyranoside	4J4Q-Rhodopsin-Octyl β-D-Glucopyranoside-Gt(CT)
5.56	Single	4X1H	Nonyl-Beta-D-Glucopyranoside	4X1H-Rhodopsin-Nonyl-β-D-Glucopyranoside-Gt(CT)
5.56	Single	5NDD	AZ8838; Na	5NDD-PAR2-AZ8838; Na
5.56	Single	5OLZ	PubChem 135566609	5OLZ-A_2A-PubChem 135566609-Na
5.56	Single	5OM1	PubChem 135566609	5OM1-A_2A-PubChem 135566609-Na
5.56	Single	5UIG	Cmpd-1	5UIG-A_2A-Cmpd-1
5.56	Single	6FK7	PubChem 132473034	6FK7-Rhodopsin-PubChem 132473034
5.56	Single	6FKD	PubChem 137349183	6FKD-Rhodopsin-PubChem 137349183
5.56	Single	6GPS	MK0812	6GPS-CCR2-MK0812
5.56	Single	6IIV	Daltroban	6IIV-TP-Daltroban
5.56	Single	6KPF	PubChem 145915889	6KPF-CB₂-PubChem 145915889-Gi1/β1/γ2
5.56	Single	6ORV	TT-OAD2	6ORV-GLP-1-TT-OAD2-Gs/β1/γ2
5.56	Single	7BU7	BI167107	7BU7-β₁-BI167107
5.56	Single	7CRH	SKF83959	7CRH-D₁-SKF83959-Gs/β1/γ2
5.56	Single	7DB6	Ramelteon	7DB6-MT₁-Ramelteon-Gi1/β1/γ2
5.56	Single	7JOZ	VFP	7JOZ-D₁-VFP-Gs/β1/γ2
5.56	Single	7JVQ	Apomorphine	7JVQ-D₁-Apomorphine-Gs/β1/γ2
5.56	Single	7LJC	SKF-81297	7LJC-D₁-SKF-81297-Mevidalen-Gs/β1/γ2
5.56	Single	7NA8	PubChem 178024	7NA8-Ghrelin-PubChem 178024-Gi1/β1/γ2
5.56	Single	7T2G	Mitragynine Pseudoindoxyl	7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2
5.56	Single	7V3Z	CP55940	7V3Z-CB₁-CP55940
5.56	Single	7VGZ	Remalteon	7VGZ-MT₁-Remalteon-Gi1/β1/γ2
5.56	Single	7VIE	S1P	7VIE-S1P₁-S1P-Gi1/β1/γ2
5.56	Single	7VIF	S-FTY720-P	7VIF-S1P₁-S-FTY720-P-Gi1/β1/γ2
5.56	Single	7VKT	LTB4	7VKT-BLT₁-LTB4-Gi1/β1/γ2
5.56	Single	7WC8	Lumateperone	7WC8-5-HT_2A-Lumateperone
5.56	Single	7X2C	Fenoldopam	7X2C-D₁-Fenoldopam-Fenoldopam-Gs/β1/γ2
5.56	Single	8CU6	LJ-4517	8CU6-A_2A-LJ-4517
5.56	Single	8CU7	LJ-4517	8CU7-A_2A-LJ-4517-Na
5.56	Single	8EJK	TAK-875	8EJK-FFA1-TAK-875-chim(NtGi1L-Gs-CtGq)/β1/γ2
5.56	Single	8GCM	L902688	8GCM-EP₄-L902688-Gi1/β1/γ2
5.56	Single	8JLZ	ST1936	8JLZ-5-HT₆-ST1936-Gs/β1/γ2
5.56	Single	8K5D	GSK256073	8K5D-HCA₂-GSK256073
5.56	Single	8KEX	DCA-3P	8KEX-MRGPRX4-DCA-3P
5.56	Single	8RLN	LUF5834	8RLN-A_2A-LUF5834
5.56	Single	8T1W	CVN424	8T1W-GPR6-CVN424
5.56	Single	8W87	METH	8W87-TA1-METH-chim(NtGi1L-Gs)/β1/γ2
5.56	Single	8W8A	RO5256390	8W8A-TA1-RO5256390-chim(NtGi1L-Gs)/β1/γ2
5.56	Single	8X17	Namodenoson	8X17-A_3A-Namodenoson-Gi1/β1/γ2
5.56	Single	8XBG	S3E-LysoPS	8XBG-GPR34-S3E-LysoPS
5.56	Single	8YH5	Riboprine	8YH5-A_3A-Riboprine-Gi1/β1/γ2
5.56	Single	8YIC	SAR247799	8YIC-S1P₁-SAR247799-Gi1/β1/γ2
5.56	Single	8ZQE	GPR15L(C11)	8ZQE-GPR15-GPR15L(C11)-Gi1/β1/γ1
5.56	Single	8ZSS	RO5263397	8ZSS-TA1-RO5263397-chim(NtGi1-Gs)/β1/γ2
5.56	Single	9CHX	S-Carazolol	9CHX-β₂-S-Carazolol
5.56	Single	9IYA	ONO-9710531	9IYA-GPR55-ONO-9710531
5.56	Consensus	5ht6_on	Orthosteric Ligand	7XTB-5-HT₆-Serotonin-Gs/β1/γ2 8JLZ-5-HT₆-ST1936-Gs/β1/γ2
5.56	Consensus	5ht6_on_gp	Orthosteric Ligand	7XTB-5-HT₆-Serotonin-Gs/β1/γ2 8JLZ-5-HT₆-ST1936-Gs/β1/γ2
5.56	Consensus	adenosine_on_gp	Orthosteric Ligand	a1_on_gp a2_on_gp a3_on_gp
5.56	Consensus	alicarboxylic_on_gp	Orthosteric Ligand	succinate_on_gp hca_on_gp
5.56	Consensus	blt1_on	Orthosteric Ligand	7VKT-BLT₁-LTB4-Gi1/β1/γ2
5.56	Consensus	blt1_on_gp	Orthosteric Ligand	7VKT-BLT₁-LTB4-Gi1/β1/γ2
5.56	Consensus	blt_on	Orthosteric Ligand	blt1_on
5.56	Consensus	blt_on_gp	Orthosteric Ligand	blt1_on_gp
5.56	Consensus	ccr2_off	Orthosteric Ligand	6GPS-CCR2-MK0812
5.56	Consensus	dop_off	Orthosteric Ligand	4EJ4-δ-Naltrindole
5.56	Consensus	gi_alicarboxylic	Orthosteric Ligand	gi_hca gi_succinate
5.56	Consensus	gi_leukotriene	Orthosteric Ligand	7VKT-BLT₁-LTB4-Gi1/β1/γ2
5.56	Consensus	gs_trace-amine	Orthosteric Ligand	8W88-TA1-SEP-363856-Gs/β1/γ2 8JLJ-TA1-T1AM-chim(NtGi1-Gs)/β1/γ2 8JLO-TA1-Ulotaront-Gs/β1/γ2 8WC4-TA1-ZH8651-chim(NtGi1-Gs)/β1/γ2 8WC7-TA1-ZH8667-chim(NtGi1-Gs)/β1/γ2 8JLR-TA1-A77636-chim(NtGi1-Gs)/β1/γ2 8JSO-TA1-AMPH-chim(NtGi1-Gs)/β1/γ2 8W87-TA1-METH-chim(NtGi1L-Gs)/β1/γ2 8W89-TA1-PEA-chim(NtGi1L-Gs)/β1/γ2 8JLP-TA1-Ralmitaront-Gs/β1/γ2 8W8A-TA1-RO5256390-chim(NtGi1L-Gs)/β1/γ2
5.56	Consensus	leukotriene_on	Orthosteric Ligand	blt_on
5.56	Consensus	leukotriene_on_gp	Orthosteric Ligand	blt_on_gp
5.26	Single	2Y00	Dobutamine	2Y00-β₁-Dobutamine
5.26	Single	4NTJ	AZD1283	4NTJ-P2Y₁₂-AZD1283
5.26	Single	4PHU	Fasiglifam	4PHU-FFA1-Fasiglifam
5.26	Single	4RWD	DIPP-NH2	4RWD-δ-DIPP-NH2-Na
5.26	Single	5C1M	BU72	5C1M-μ-BU72
5.26	Single	5OM4	PubChem 135566609	5OM4-A_2A-PubChem 135566609-Na
5.26	Single	5T1A	PubChem 68764898; PubChem 12093170	5T1A-CCR2-PubChem 68764898; PubChem 12093170
5.26	Single	5ZK3	3-quinuclidinyl-benzilate	5ZK3-M₂-3-quinuclidinyl-benzilate
5.26	Single	6E67	BI167107	6E67-β₂-BI167107-Gs (fused)
5.26	Single	6GDG	NECA	6GDG-A_2A-NECA-Gs/β1/γ1
5.26	Single	6GPX	MK0812	6GPX-CCR2-MK0812
5.26	Single	6KPC	PubChem 145915889	6KPC-CB₂-PubChem 145915889
5.26	Single	6ME6	2-Phenylmelatonin	6ME6-MT₂-2-Phenylmelatonin
5.26	Single	6ME7	2-Phenylmelatonin	6ME7-MT₂-2-Phenylmelatonin
5.26	Single	6ME8	2-Phenylmelatonin	6ME8-MT₂-2-Phenylmelatonin
5.26	Single	6W2X	PubChem 23727970	6W2X-GABA_B1, GABA_B2-PubChem 5311042-PubChem 23727970
5.26	Single	6W2X	PubChem 23727970	6W2X-GABA_B1, GABA_B2-PubChem 5311042-PubChem 23727970
5.26	Single	6Z4Q	SR142948A	6Z4Q-NTS₁-SR142948A
5.26	Single	6Z4S	SR48692	6Z4S-NTS₁-SR48692
5.26	Single	7BB7	AVP	7BB7-V₂-AVP-Gs/β1/γ2
5.26	Single	7C4S	S1P	7C4S-S1P₃-S1P
5.26	Single	7C61	Ergotamine	7C61-5-HT_1B-Ergotamine
5.26	Single	7CKX	A77636	7CKX-D₁-A77636-Gs/β1/γ2
5.26	Single	7EPF	NAM597	7EPF-mGlu2; mGlu2-NAM597
5.26	Single	7EUO	fMLF	7EUO-FPR1-ALX-fMLF-Gi1/β1/γ2
5.26	Single	7LD3	Adenosine	7LD3-A₁-Adenosine-PubChem 25263603-Gi2/β1/γ2
5.26	Single	7VFX	fMLF	7VFX-FPR1-ALX-fMLF-Gi1/β1/γ2
5.26	Single	7VV4	Cortistatin-14	7VV4-MRGPRX2-Cortistatin-14
5.26	Single	7W41	PD176252	7W41-BB₂-PD176252
5.26	Single	7WIG	L-054,264	7WIG-SST2-L-054,264-Gi1/β1/γ2
5.26	Single	7X1T	Taltirelin	7X1T-TRH-Taltirelin-chim(NtGi2L-Gs-CtGq)/β1/γ2
5.26	Single	8EJC	TAK-875	8EJC-FFA1-TAK-875-chim(NtGi1L-Gs-CtGq)/β1/γ2
5.26	Single	8GDC	PGE2	8GDC-EP₃-PGE2-Gi1/β1/γ2
5.26	Single	8HNL	PS372424	8HNL-CXCR3-PS372424-Gi1/β1/γ2
5.26	Single	8I7W	GSK256073	8I7W-HCA₂-GSK256073-Gi1/β1/γ2
5.26	Single	8J18	(3R)-3-Hydroxydodecanoic acid	8J18-GPR84-(3R)-3-Hydroxydodecanoic acid-Gi1/β1/γ2
5.26	Single	8JXS	PF-6142	8JXS-D₁-PF-6142
5.26	Single	8K8J	Fenofibrate	8K8J-CB₁-Fenofibrate-chim(Gs-CtGq)/β1/γ2
5.26	Single	8SZI	Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW	8SZI-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi3/β1/γ2
5.26	Single	8XQP	Cholesterol	8XQP-TAS2R14-Cholesterol-Aristolochic acid A-Gt3/β1/γ1
5.26	Single	9DQH	EP-2825	9DQH-MRGPRD-EP-2825-chim(NtGi1-Gs-CtGq)/β1/γ2
5.26	Single	9DQJ	EP-3945	9DQJ-MRGPRD-EP-3945-chim(NtGi1-Gs-CtGq)/β1/γ2
5.26	Single	9EAH	Olmesartan	9EAH-AT₁-Olmesartan-Nanobody AT209
5.26	Single	9IYB	Prostaglandin	9IYB-DP₂-Prostaglandin-A1D5Q-Gi1/β1/γ2
5.26	Consensus	bb2_off	Orthosteric Ligand	7W41-BB₂-PD176252
5.26	Consensus	blt1_off	Orthosteric Ligand	5X33-BLT₁-BIIL260 7K15-BLT₁-MKD046-Na
5.26	Consensus	blt_off	Orthosteric Ligand	blt1_off
5.26	Consensus	bombesin_off	Orthosteric Ligand	bb2_off
5.26	Consensus	cb2_on	Orthosteric Ligand	8GUR-CB₂-CP55,940-Gi1/β1/γ2 8GUS-CB₂-HU-308-Gi1/β1/γ2 8GUT-CB₂-LEI-102-Gi1/β1/γ2 6KPF-CB₂-PubChem 145915889-Gi1/β1/γ2 6PT0-CB₂-WIN 55212-2-Gi1/β1/γ2 8GUQ-CB₂-Olorinab-Gi1/β1/γ2
5.26	Consensus	cb2_on_gp	Orthosteric Ligand	8GUR-CB₂-CP55,940-Gi1/β1/γ2 8GUS-CB₂-HU-308-Gi1/β1/γ2 8GUT-CB₂-LEI-102-Gi1/β1/γ2 6KPF-CB₂-PubChem 145915889-Gi1/β1/γ2 6PT0-CB₂-WIN 55212-2-Gi1/β1/γ2 8GUQ-CB₂-Olorinab-Gi1/β1/γ2
5.26	Consensus	cyslt_off	Orthosteric Ligand	cyslt2_off cyslt1_off
5.26	Consensus	d1_on	Orthosteric Ligand	7F0T-D₁-Dopamine-Gs/β1/γ2 7CKY-D₁-PW0464-Gs/β1/γ2 8IRR-D₁-Rotigotine-Gs/β1/γ2 7JV5-D₁-SKF81297-Gs/β1/γ2 7JVP-D₁-SKF83959-Gs/β1/γ2 7X2D-D₁-Tavapadon-Gs/β1/γ2 7CKX-D₁-A77636-Gs/β1/γ2 7JVQ-D₁-Apomorphine-Gs/β1/γ2 7CKW-D₁-Fenoldopam-Gs/β1/γ2
5.26	Consensus	fpr1-alx_on	Orthosteric Ligand	7VFX-FPR1-ALX-fMLF-Gi1/β1/γ2
5.26	Consensus	fpr1-alx_on_gp	Orthosteric Ligand	7VFX-FPR1-ALX-fMLF-Gi1/β1/γ2
5.26	Consensus	gs_amine	Orthosteric Ligand	gs_5ht gs_adrenergic gs_dopamine gs_histamine gs_trace-amine
5.26	Consensus	ta1_on	Orthosteric Ligand	8W87-TA1-METH-chim(NtGi1L-Gs)/β1/γ2 8W89-TA1-PEA-chim(NtGi1L-Gs)/β1/γ2 8JLP-TA1-Ralmitaront-Gs/β1/γ2 8W8A-TA1-RO5256390-chim(NtGi1L-Gs)/β1/γ2 8W88-TA1-SEP-363856-Gs/β1/γ2 8JLO-TA1-Ulotaront-Gs/β1/γ2 8JLR-TA1-A77636-chim(NtGi1-Gs)/β1/γ2 8JSO-TA1-AMPH-chim(NtGi1-Gs)/β1/γ2 8ZSP-TA1-LSD-chim(NtGi1L-Gs-CtGq)/β1/γ2
5.26	Consensus	trace-amine_on	Orthosteric Ligand	ta1_on
5.00	Single	2YDV	NECA	2YDV-A_2A-NECA
5.00	Single	3P0G	BI167107	3P0G-β₂-BI167107
5.00	Single	3PDS	Hydroxybenzylisoproterenol	3PDS-β₂-Hydroxybenzylisoproterenol
5.00	Single	3UON	3-quinuclidinyl-benzilate	3UON-M₂-3-quinuclidinyl-benzilate
5.00	Single	4LDL	Hydroxybenzylisoproterenol	4LDL-β₂-Hydroxybenzylisoproterenol
5.00	Single	4UHR	CGS21680	4UHR-A_2A-CGS21680
5.00	Single	5A8E	7-Methylcyanopindolol	5A8E-β₁-7-Methylcyanopindolol-Na
5.00	Single	5G53	NECA	5G53-A_2A-NECA-Gs
5.00	Single	5TZR	MK8666	5TZR-FFA1-MK8666
5.00	Single	5XR8	AM841	5XR8-CB₁-AM841
5.00	Single	5XRA	AM11542	5XRA-CB₁-AM11542
5.00	Single	5ZBH	BMS-193885	5ZBH-Y₁-BMS-193885
5.00	Single	5ZHP	PubChem 134828589	5ZHP-M₃-PubChem 134828589
5.00	Single	6DDE	Damgo	6DDE-μ-Damgo-Gi1/β1/γ2
5.00	Single	6GT3	Imaradenant	6GT3-A_2A-Imaradenant-Na
5.00	Single	6J21	Aprepitant	6J21-NK₁-Aprepitant
5.00	Single	6N48	BI167107	6N48-β₂-BI167107-PubChem 138454256
5.00	Single	6N4B	MDMB-Fubinaca	6N4B-CB₁-MDMB-Fubinaca-Gi1/β1/γ2
5.00	Single	6O3C	Cholesterol	6O3C-SMO-SAG21k-Cholesterol
5.00	Single	7CKY	PW0464	7CKY-D₁-PW0464-Gs/β1/γ2
5.00	Single	7EW1	Siponimod	7EW1-S1P₅-Siponimod-Gi1/β1/γ2
5.00	Single	7EW3	S1P	7EW3-S1P₃-S1P-Gi1/β1/γ2
5.00	Single	7EW7	SEW2871	7EW7-S1P₁-SEW2871-Gi1/β1/γ2
5.00	Single	7FEE	CP55940	7FEE-CB₁-CP55940-ZCZ011
5.00	Single	7JV5	SKF81297	7JV5-D₁-SKF81297-Gs/β1/γ2
5.00	Single	7JVP	SKF83959	7JVP-D₁-SKF83959-Gs/β1/γ2
5.00	Single	7M8W	15r-Methyl-Prostaglandin D2	7M8W-DP₂-15r-Methyl-Prostaglandin D2-Na
5.00	Single	7S8M	Cortistatin-14	7S8M-MRGPRX2-Cortistatin-14-Gi1/β1/γ2
5.00	Single	7WV9	CP55940	7WV9-CB₁-CP55940-ZCZ011-Gi2/β1/γ2
5.00	Single	7XAV	Lanreotide	7XAV-SST2-Lanreotide-Gi1/β1/γ2
5.00	Single	8DCS	Cyanopindolol	8DCS-β₁-Cyanopindolol-Gs/β1/γ2
5.00	Single	8E0G	BU72	8E0G-μ-BU72
5.00	Single	8GDB	PGE2	8GDB-EP₄-PGE2-Gs/β1/γ2
5.00	Single	8GUS	HU-308	8GUS-CB₂-HU-308-Gi1/β1/γ2
5.00	Single	8HPT	C5a anaphylatoxin C-terminal peptide	8HPT-C5a₁-C5a anaphylatoxin C-terminal peptide-Go/β1/γ2
5.00	Single	8IRR	Rotigotine	8IRR-D₁-Rotigotine-Gs/β1/γ2
5.00	Single	8IUK	PGF2-alpha	8IUK-FP-alpha-PGF2-α-chim(NtGi1-Gs-CtGq)/β1/γ2
5.00	Single	8IYH	MK6892	8IYH-HCA₂-MK6892-Go/β1/γ2
5.00	Single	8JLP	Ralmitaront	8JLP-TA1-Ralmitaront-Gs/β1/γ2
5.00	Single	8JSR	Anamorelin	8JSR-Ghrelin-Anamorelin-chim(NtGi1-Gs-CtGq)/β1/γ2
5.00	Single	8JXV	Clozapine	8JXV-H₄-Clozapine-Gi1/β1/γ2
5.00	Single	8JXW	VUF6884	8JXW-H₄-VUF6884-Gi1/β1/γ2
5.00	Single	8T1V	PubChem 118310209	8T1V-GPR6-PubChem 118310209-Na
5.00	Single	8WU1	PubChem 119025665	8WU1-CB₁-PubChem 119025665-Arrestin2
5.00	Single	8X79	MRE-269	8X79-I2-MRE-269-Gs/β1/γ2
5.00	Single	8XJM	Latanoprost	8XJM-FP-alpha-Latanoprost-chim(NtGi2-Gs-CtGq)/β1/γ2
5.00	Single	8XZI	CMF-019	8XZI-Apelin-CMF-019-Gi1/β1/γ2
5.00	Single	8ZR5	Firuglipel	8ZR5-GPR119-Firuglipel-Gs/β1/γ2
5.00	Single	9B65	KCA	9B65-CB₁-KCA-Gi1/β1/γ2
5.00	Single	9BJK	NAM	9BJK-μ-Naloxone-NAM
5.00	Single	9F33	FOB02-04A	9F33-D₃-FOB02-04A-Go1/β1/γ2
5.00	Single	9GE2	ML184	9GE2-GPR55-ML184-Cholesterol-chim(CtGi1-G13)/β1/γ2
5.00	Consensus	a2_on	Orthosteric Ligand	a2b_on
5.00	Consensus	a2_on_gp	Orthosteric Ligand	a2b_on_gp
5.00	Consensus	a2b_on	Orthosteric Ligand	8HDP-A_2B-Adenosine-Gs/β1/γ2 7XY6-A_2B-BAY 60-6583-chim(NtGi1-Gs)/β1/γ2 7XY7-A_2B-NECA-chim(NtGi1-Gs)/β1/γ2 8HDO-A_2B-BAY 60-6583-Gs/β1/γ2
5.00	Consensus	a2b_on_gp	Orthosteric Ligand	8HDP-A_2B-Adenosine-Gs/β1/γ2 7XY6-A_2B-BAY 60-6583-chim(NtGi1-Gs)/β1/γ2 7XY7-A_2B-NECA-chim(NtGi1-Gs)/β1/γ2 8HDO-A_2B-BAY 60-6583-Gs/β1/γ2
5.00	Consensus	d1_on_gp	Orthosteric Ligand	7F0T-D₁-Dopamine-Gs/β1/γ2 7CKY-D₁-PW0464-Gs/β1/γ2 8IRR-D₁-Rotigotine-Gs/β1/γ2 7JV5-D₁-SKF81297-Gs/β1/γ2 7JVP-D₁-SKF83959-Gs/β1/γ2 7X2D-D₁-Tavapadon-Gs/β1/γ2 7CKX-D₁-A77636-Gs/β1/γ2 7JVQ-D₁-Apomorphine-Gs/β1/γ2 7CKW-D₁-Fenoldopam-Gs/β1/γ2
5.00	Consensus	ffa2_on	Orthosteric Ligand	8J22-FFA2-TUG-1375-Gi1/β1/γ2
5.00	Consensus	ffa_on	Orthosteric Ligand	ffa2_on ffa3_on
5.00	Consensus	ffa_on_gp	Orthosteric Ligand	ffa2_on_gp ffa3_on_gp
5.00	Consensus	gi_cannabinoid	Orthosteric Ligand	8GUR-CB₂-CP55,940-Gi1/β1/γ2 8GUS-CB₂-HU-308-Gi1/β1/γ2 8GUT-CB₂-LEI-102-Gi1/β1/γ2 8GUQ-CB₂-Olorinab-Gi1/β1/γ2 6KPF-CB₂-PubChem 145915889-Gi1/β1/γ2 6PT0-CB₂-WIN 55212-2-Gi1/β1/γ2 6KPG-CB₁-AM841-Gi1/β1/γ2
5.00	Consensus	gi_ffa	Orthosteric Ligand	8J21-FFA3-Butyric acid-Gi1/β1/γ2 8J22-FFA2-TUG-1375-Gi1/β1/γ2
5.00	Consensus	gs_adenosine	Orthosteric Ligand	8HDP-A_2B-Adenosine-Gs/β1/γ2 8HDO-A_2B-BAY 60-6583-Gs/β1/γ2 7XY7-A_2B-NECA-chim(NtGi1-Gs)/β1/γ2 7XY6-A_2B-BAY 60-6583-chim(NtGi1-Gs)/β1/γ2
5.00	Consensus	gs_adrenergic	Orthosteric Ligand	7DHI-β₂-Salbutamol-Gs/β1/γ2 7XJI-β₃-Solabegron-Gs/β1/γ2 7JJO-β₁-Isoprenaline-Gs/β1/γ2 6NI3-β₂-BI167107-Gs/β1/γ2 8DCR-β₁-Dobutamine-Gs/β1/γ2 7XJH-β₃-Isoproterenol-Gs/β1/γ2 7DH5-β₃-Mirabegron-Gs/β1/γ2
5.00	Consensus	gs_dopamine	Orthosteric Ligand	7F0T-D₁-Dopamine-Gs/β1/γ2 7CKW-D₁-Fenoldopam-Gs/β1/γ2 7CKY-D₁-PW0464-Gs/β1/γ2 8IRV-D₅-Rotigotine-chim(NtGi1-Gs)/β1/γ2 8IRR-D₁-Rotigotine-Gs/β1/γ2 7JV5-D₁-SKF81297-Gs/β1/γ2 7JVP-D₁-SKF83959-Gs/β1/γ2 7X2D-D₁-Tavapadon-Gs/β1/γ2 7CKX-D₁-A77636-Gs/β1/γ2 7JVQ-D₁-Apomorphine-Gs/β1/γ2
5.00	Consensus	gs_nucleotide	Orthosteric Ligand	gs_adenosine
5.00	Consensus	npy_off	Orthosteric Ligand	npy1_off npy2_off
5.00	Consensus	s1p5_on	Orthosteric Ligand	7EW1-S1P₅-Siponimod-Gi1/β1/γ2
5.00	Consensus	s1p5_on_gp	Orthosteric Ligand	7EW1-S1P₅-Siponimod-Gi1/β1/γ2
5.00	Consensus	ta1_on_gp	Orthosteric Ligand	8W87-TA1-METH-chim(NtGi1L-Gs)/β1/γ2 8W89-TA1-PEA-chim(NtGi1L-Gs)/β1/γ2 8JLP-TA1-Ralmitaront-Gs/β1/γ2 8W8A-TA1-RO5256390-chim(NtGi1L-Gs)/β1/γ2 8W88-TA1-SEP-363856-Gs/β1/γ2 8JLO-TA1-Ulotaront-Gs/β1/γ2 8JLR-TA1-A77636-chim(NtGi1-Gs)/β1/γ2 8JSO-TA1-AMPH-chim(NtGi1-Gs)/β1/γ2 8ZSP-TA1-LSD-chim(NtGi1L-Gs-CtGq)/β1/γ2
5.00	Consensus	trace-amine_on_gp	Orthosteric Ligand	ta1_on_gp
4.76	Single	2YCX	Cyanopindolol	2YCX-β₁-Cyanopindolol
4.76	Single	4LDE	BI167107	4LDE-β₂-BI167107
4.76	Single	4RWA	DIPP-NH2	4RWA-δ-DIPP-NH2
4.76	Single	5TZY	MK8666; PubChem 127053597	5TZY-FFA1-MK8666; PubChem 127053597
4.76	Single	5UNH	PubChem 126456406	5UNH-AT₂-PubChem 126456406
4.76	Single	5X33	BIIL260	5X33-BLT₁-BIIL260
4.76	Single	6A93	Risperidone	6A93-5-HT_2A-Risperidone
4.76	Single	6CM4	Risperidone	6CM4-D₂-Risperidone
4.76	Single	6H7N	S-Xamoterol	6H7N-β₁-S-Xamoterol
4.76	Single	6IIU	Ramatroban	6IIU-TP-Ramatroban
4.76	Single	6KQI	CP55940	6KQI-CB₁-CP55940-Org27569
4.76	Single	6RZ7	ONO-2570366	6RZ7-CysLT₂-ONO-2570366
4.76	Single	6XBL	Cholesterol	6XBL-SMO-SAG-Cholesterol-Gi1/β1/γ2
4.76	Single	7BZ2	Arformoterol	7BZ2-β₂-Arformoterol-Gs/β1/γ2
4.76	Single	7EO4	BAF312	7EO4-S1P₁-BAF312-Gi1/β1/γ2
4.76	Single	7EXD	Lasmiditan	7EXD-5-HT_1F-Lasmiditan-Gi1/β1/γ2
4.76	Single	7K15	MKD046	7K15-BLT₁-MKD046-Na
4.76	Single	7MTR	ADX55164	7MTR-mGlu2; mGlu2-Glutamate-ADX55164
4.76	Single	7SUS	PubChem 122701908	7SUS-Apelin-PubChem 122701908
4.76	Single	7W0L	PubChem 122701908	7W0L-Apelin-PubChem 122701908-Gi1/β1/γ2
4.76	Single	7W0L	PubChem 122701908	7W0L-Apelin-PubChem 122701908-Gi1/β1/γ2
4.76	Single	7XW9	TRH	7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/β1/γ2
4.76	Single	7XZ5	Lysophosphatidylcholine	7XZ5-GPR119-Lysophosphatidylcholine-Gs/β1/γ2
4.76	Single	8G05	6-OAU	8G05-GPR84-6-OAU-Gi1/β1/γ2
4.76	Single	8IQ6	Latanoprost	8IQ6-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/β1/γ2
4.76	Single	8JJ8	Formoterol	8JJ8-β₂-Formoterol
4.76	Single	8JJL	Olodaterol	8JJL-β₂-Olodaterol
4.76	Single	8JWZ	AB928	8JWZ-A_2A-AB928-Na
4.76	Single	8JZ7	MK6892	8JZ7-HCA₂-MK6892-Gi1/β1/γ2
4.76	Single	8SZH	Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW	8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/β1/γ2
4.76	Single	8WRB	Lysophosphatidylserine	8WRB-GPR34-Lysophosphatidylserine-Gi1/β1/γ2
4.76	Single	8XJN	Cloprosetnol	8XJN-TP-Cloprosetnol-chim(NtGi1-Gs-CtGq)/β1/γ2
4.76	Consensus	5ht1f_on	Orthosteric Ligand	7EXD-5-HT_1F-Lasmiditan-Gi1/β1/γ2
4.76	Consensus	5ht1f_on_gp	Orthosteric Ligand	7EXD-5-HT_1F-Lasmiditan-Gi1/β1/γ2
4.76	Consensus	beta_on	Orthosteric Ligand	beta1_on beta2_on beta3_on
4.76	Consensus	beta_on_gp	Orthosteric Ligand	beta1_on_gp beta2_on_gp beta3_on_gp
4.76	Consensus	cannabinoid_on	Orthosteric Ligand	cb2_on cb1_on
4.76	Consensus	cannabinoid_on_gp	Orthosteric Ligand	cb2_on_gp cb1_on_gp
4.76	Consensus	cb1_on	Orthosteric Ligand	6KPG-CB₁-AM841-Gi1/β1/γ2 8K8J-CB₁-Fenofibrate-chim(Gs-CtGq)/β1/γ2
4.76	Consensus	ffa2_on_gp	Orthosteric Ligand	8J22-FFA2-TUG-1375-Gi1/β1/γ2
4.76	Consensus	kop_on	Orthosteric Ligand	8F7W-κ-Dynorphin-Gi1/β1/γ2 8DZS-κ-GR89,696-chim(NtGi2-Gz)/β1/γ2 8DZP-κ-momSalB-Gi1/β1/γ2
4.76	Consensus	m4_on	Orthosteric Ligand	7TRS-M₄-Acetylcholine-Gi1/β1/γ2 7V6A-M₄-PubChem 9864275-Gi1/β1/γ2 8E9X-M₄-2-Deoxycytidine-chim(NtGi1-Go)/β1/γ2 7TRK-M₄-Iperoxo-Gi1/β1/γ2
4.76	Consensus	m4_on_gp	Orthosteric Ligand	7TRS-M₄-Acetylcholine-Gi1/β1/γ2 7V6A-M₄-PubChem 9864275-Gi1/β1/γ2 8E9X-M₄-2-Deoxycytidine-chim(NtGi1-Go)/β1/γ2 7TRK-M₄-Iperoxo-Gi1/β1/γ2
4.76	Consensus	mop_on	Orthosteric Ligand	8F7R-μ-Endomorphin-Gi1/β1/γ2 8EF5-μ-Fentanyl-Gi1/β1/γ2 7SCG-μ-FH210-Gi1/β1/γ2 7T2H-μ-Lofentanil-Gi1/β1/γ2 7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2 8EF6-μ-Morphine-Gi1/β1/γ2 8EFB-μ-Oliceridine-Gi1/β1/γ2 7U2L-μ-PubChem 163201242-Gi1/β1/γ2 8EFO-μ-PZM21-Gi1/β1/γ2 8EFL-μ-SR17018-Gi1/β1/γ2 8F7Q-μ-β-Endorphin-Gi1/β1/γ2 7U2K-μ-C6-guano-Gi1/β1/γ2 8EFQ-μ-Damgo-Gi1/β1/γ2
4.76	Consensus	mop_on_gp	Orthosteric Ligand	8F7R-μ-Endomorphin-Gi1/β1/γ2 8EF5-μ-Fentanyl-Gi1/β1/γ2 7SCG-μ-FH210-Gi1/β1/γ2 7T2H-μ-Lofentanil-Gi1/β1/γ2 7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2 8EF6-μ-Morphine-Gi1/β1/γ2 8EFB-μ-Oliceridine-Gi1/β1/γ2 7U2L-μ-PubChem 163201242-Gi1/β1/γ2 8EFO-μ-PZM21-Gi1/β1/γ2 8EFL-μ-SR17018-Gi1/β1/γ2 8F7Q-μ-β-Endorphin-Gi1/β1/γ2 7U2K-μ-C6-guano-Gi1/β1/γ2 8EFQ-μ-Damgo-Gi1/β1/γ2
4.76	Consensus	opioid_off	Orthosteric Ligand	mop_off nop_off dop_off kop_off
4.76	Consensus	orexin_on	Orthosteric Ligand	ox2_on
4.76	Consensus	s1p3_on	Orthosteric Ligand	7EW3-S1P₃-S1P-Gi1/β1/γ2 7EW4-S1P₃-CYM5541-Gi1/β1/γ2 7EW2-S1P₃-Fingolimod-Gi1/β1/γ2
4.76	Consensus	trh_on	Orthosteric Ligand	7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/β1/γ2
4.76	Consensus	trh_on_gp	Orthosteric Ligand	7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/β1/γ2
4.55	Single	2YCZ	Iodocyanopindolol	2YCZ-β₁-Iodocyanopindolol
4.55	Single	4BVN	Cyanopindolol	4BVN-β₁-Cyanopindolol-Na
4.55	Single	5TUD	Ergotamine	5TUD-5-HT_2B-Ergotamine
4.55	Single	6BQH	Ritanserin	6BQH-5-HT_2C-Ritanserin
4.55	Single	6DDF	Damgo	6DDF-μ-Damgo-Gi1/β1/γ2
4.55	Single	6H7L	Dobutamine	6H7L-β₁-Dobutamine
4.55	Single	6IBL	Arformoterol	6IBL-β₁-Arformoterol
4.55	Single	6RZ9	ONO-2770372	6RZ9-CysLT₂-ONO-2770372
4.55	Single	6TKO	Arformoterol	6TKO-β₁-Arformoterol-Arrestin2
4.55	Single	7MTS	ADX55164	7MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/β1/γ2
4.55	Single	7SK7	CCX662	7SK7-ACKR3-CXCL12-CCX662
4.55	Single	7SK8	CCX662	7SK8-ACKR3-CXCL12-CCX662
4.55	Single	7VGY	2-Iodomelatonin	7VGY-MT₁-2-Iodomelatonin-Gi1/β1/γ2
4.55	Single	7X1U	TRH	7X1U-TRH-TRH-chim(NtGi2L-Gs-CtGq)/β1/γ2
4.55	Single	7X2D	Tavapadon	7X2D-D₁-Tavapadon-Gs/β1/γ2
4.55	Single	8E9X	2-Deoxycytidine	8E9X-M₄-2-Deoxycytidine-chim(NtGi1-Go)/β1/γ2
4.55	Single	8FX5	Xanomeline	8FX5-M₄-Xanomeline-Xanomeline-Gi1/β1/γ2
4.55	Single	8GAG	PubChem 170838490	8GAG-CB₁-PubChem 170838490-Gi1/β1/γ2
4.55	Single	8GUT	LEI-102	8GUT-CB₂-LEI-102-Gi1/β1/γ2
4.55	Single	8I95	EP54	8I95-C3a_B-EP54-Go/β1/γ2
4.55	Single	8J19	LY237	8J19-GPR84-LY237-Gi1/β1/γ2
4.55	Single	8T3O	TUG-891	8T3O-FFA4-TUG-891-2Y5-chim(NtGi2L-Gs-CtGq)/β1/γ2
4.55	Single	8XJK	Cloprosetnol	8XJK-FP-alpha-Cloprosetnol-chim(NtGi1-Gs-CtGq)/β1/γ2
4.55	Single	8XJO	U46619	8XJO-TP-U46619-chim(NtGi1-Gs-CtGq)/β1/γ2
4.55	Consensus	5ht2c_off	Orthosteric Ligand	6BQH-5-HT_2C-Ritanserin
4.55	Consensus	beta1_on	Orthosteric Ligand	8DCR-β₁-Dobutamine-Gs/β1/γ2 7S0F-β₁-Isoprenaline-Gi1/β1/γ2
4.55	Consensus	beta1_on_gp	Orthosteric Ligand	8DCR-β₁-Dobutamine-Gs/β1/γ2 7S0F-β₁-Isoprenaline-Gi1/β1/γ2
4.55	Consensus	cb1_on_gp	Orthosteric Ligand	6KPG-CB₁-AM841-Gi1/β1/γ2 8K8J-CB₁-Fenofibrate-chim(Gs-CtGq)/β1/γ2
4.55	Consensus	cyslt2_off	Orthosteric Ligand	6RZ7-CysLT₂-ONO-2570366 6RZ8-CysLT₂-ONO-2080365 6RZ9-CysLT₂-ONO-2770372
4.55	Consensus	kop_on_gp	Orthosteric Ligand	8F7W-κ-Dynorphin-Gi1/β1/γ2 8DZS-κ-GR89,696-chim(NtGi2-Gz)/β1/γ2 8DZP-κ-momSalB-Gi1/β1/γ2
4.55	Consensus	orexin_on_gp	Orthosteric Ligand	ox2_on_gp
4.55	Consensus	prostanoid_on	Orthosteric Ligand	tp_on fp-alpha_on
4.55	Consensus	prostanoid_on_gp	Orthosteric Ligand	tp_on_gp fp-alpha_on_gp
4.55	Consensus	tp_on	Orthosteric Ligand	8XJO-TP-U46619-chim(NtGi1-Gs-CtGq)/β1/γ2
4.55	Consensus	tp_on_gp	Orthosteric Ligand	8XJO-TP-U46619-chim(NtGi1-Gs-CtGq)/β1/γ2
4.35	Single	3NY9	ICI118-551	3NY9-β₂-ICI118-551
4.35	Single	5EE7	MK0893	5EE7-Glucagon-MK0893
4.35	Single	5ZTY	AM10257	5ZTY-CB₂-AM10257
4.35	Single	6PT3	DPI-287	6PT3-δ-DPI-287
4.35	Single	6RZ6	ONO-2570366	6RZ6-CysLT₂-ONO-2570366
4.35	Single	7F9Z	GHRP-6	7F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/β1/γ2
4.35	Single	7S8L	Cortistatin-14	7S8L-MRGPRX2-Cortistatin-14-chim(NtGi2L-Gs-CtGq)/β1/γ2
4.35	Single	8F7R	Endomorphin	8F7R-μ-Endomorphin-Gi1/β1/γ2
4.35	Single	8IEI	A1LYA	8IEI-GPR156-A1LYA
4.35	Single	8J22	TUG-1375	8J22-FFA2-TUG-1375-Gi1/β1/γ2
4.35	Single	8JLR	A77636	8JLR-TA1-A77636-chim(NtGi1-Gs)/β1/γ2
4.35	Single	8X3L	XWD	8X3L-CB₂-XWD-Gi1/β1/γ2
4.35	Single	8X5Y	Astemizole	8X5Y-H₁-Astemizole
4.35	Consensus	cb2_off	Orthosteric Ligand	5ZTY-CB₂-AM10257
4.17	Single	6RZ8	ONO-2080365	6RZ8-CysLT₂-ONO-2080365
4.17	Single	7F4I	SHU9119	7F4I-MC₁-SHU9119-chim(NtGi1-Gs)/β1/γ2
4.17	Single	7W56	Neuromedin-S	7W56-NMUR1-Neuromedin-S-chim(NtGi1-Gs-CtGq)/β1/γ2
4.17	Single	7WKD	TRH	7WKD-TRH-TRH-chim(NtGi1-Gs-CtGq)/β1/γ2
4.17	Single	8DCR	Dobutamine	8DCR-β₁-Dobutamine-Gs/β1/γ2
4.17	Single	8IEB	A1LYA	8IEB-GPR156-A1LYA
4.17	Single	8IEI	A1LYA	8IEI-GPR156-A1LYA
4.17	Single	8IEP	A1LYA	8IEP-GPR156-A1LYA
4.17	Single	8IEP	A1LYA	8IEP-GPR156-A1LYA
4.17	Single	8IZB	Lysophosphatidylserine	8IZB-GPR174-Lysophosphatidylserine-Gs/β1/γ2
4.17	Single	8WKY	PG-934	8WKY-MC₄-PG-934
4.17	Single	8XFT	R-spondin-2	8XFT-LGR4-R-spondin-2-ZNRF3
4.17	Single	8Y69	R-spondin-2	8Y69-LGR4-R-spondin-2-Cholesterol-ZNRF3
4.17	Single	8ZSP	LSD	8ZSP-TA1-LSD-chim(NtGi1L-Gs-CtGq)/β1/γ2
4.00	Single	6HLO	Aprepitant	6HLO-NK₁-Aprepitant
4.00	Single	7DDZ	JNJ-31020028	7DDZ-Y₂-JNJ-31020028
4.00	Consensus	mc5_on	Orthosteric Ligand	8INR-MC₅-α-MSH-Ca-chim(NtGi1-Gs)/β1/γ2 8IOD-MC₅-PG-901-Ca-chim(NtGi1-Gs)/β1/γ2
4.00	Consensus	npy2_off	Orthosteric Ligand	7DDZ-Y₂-JNJ-31020028
3.85	Single	6W25	SHU9119	6W25-MC₄-SHU9119-Ca
3.85	Single	8WVU	R-spondin-1	8WVU-LGR4-R-spondin-1-RNF43
3.85	Single	8XIQ	L796778	8XIQ-SST3-L796778-chim(NtGi1-Gs-CtGi1)/β1/γ2
3.85	Single	8Y69	R-spondin-2	8Y69-LGR4-R-spondin-2-Cholesterol-ZNRF3
3.85	Single	9B54	A1AIW	9B54-CB₁-A1AIW-Gi1/β1/γ2
3.70	Single	6WIV	PubChem 52923113; PubChem 52924645	6WIV-GABA_B1, GABA_B2-PubChem 52923113; PubChem 52924645
3.70	Single	7AD3	Alpha-factor mating pheromone	7AD3-STE2-α-factor mating pheromone-Gi1/STE4/γ2
3.70	Single	7WUI	IP15	7WUI-ADGRG2-IP15-chim(NtGi1-Gs)/β1/γ2
3.70	Single	8IED	A1LYA	8IED-GPR156-A1LYA-Go/β1/γ2
3.70	Single	8XFP	R-spondin-2	8XFP-LGR4-R-spondin-2-ZNRF3
3.70	Consensus	mc5_on_gp	Orthosteric Ligand	8INR-MC₅-α-MSH-Ca-chim(NtGi1-Gs)/β1/γ2 8IOD-MC₅-PG-901-Ca-chim(NtGi1-Gs)/β1/γ2
3.57	Single	7XV3	Lysophosphatidylserine	7XV3-GPR174-Lysophosphatidylserine-chim(NtGi1-Gs)/β1/γ2
3.57	Single	8IOD	PG-901	8IOD-MC₅-PG-901-Ca-chim(NtGi1-Gs)/β1/γ2
3.57	Consensus	p2y10_on	Orthosteric Ligand	8KGG-P2Y10-LPS-chim(NtGi2-G13)/β1/γ2
3.33	Single	8XFS	R-spondin-2	8XFS-LGR4-R-spondin-2-ZNRF3
3.33	Consensus	p2y10_on_gp	Orthosteric Ligand	8KGG-P2Y10-LPS-chim(NtGi2-G13)/β1/γ2
3.23	Single	8KGG	LPS	8KGG-P2Y10-LPS-chim(NtGi2-G13)/β1/γ2

PDB Summary
PDB	4O9R
Class	F
SubFamily	Protein
Type	Frizzled
SubType	SMO
Species	Homo Sapiens
Ligand	Cyclopamine
Other Ligand(s)	-
Protein Partners	-
PDB Resolution	3.2
Date	2014-03-05
D.O.I.	10.1038/ncomms4309

Net Summary
I_min	3.75
Number of Linked Nodes	312
Number of Links	361
Number of Hubs	52
Number of Links mediated by Hubs	193
Number of Communities	8
Number of Nodes involved in Communities	66
Number of Links involved in Communities	97

Path Summary
Number Of Nodes in MetaPath	62
Number Of Links MetaPath	61
Number of Shortest Paths	71936
Length Of Smallest Path	3
Average Path Length	14.9436
Length of Longest Path	35
Minimum Path Strength	1.17
Average Path Strength	7.14237
Maximum Path Strength	22.32
Minimum Path Correlation	0.7
Average Path Correlation	0.940976
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	4
Average % Of Corr. Nodes	56.1903
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	49.5808
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function	• binding • tetrapyrrole binding • heme binding • electron transfer activity • cation binding • transition metal ion binding • iron ion binding • ion binding • metal ion binding • small molecule binding • patched binding • protein binding • signaling receptor binding • molecular transducer activity • G protein-coupled receptor activity • transmembrane signaling receptor activity • signaling receptor activity • protein serine/threonine kinase activity • enzyme regulator activity • catalytic activity, acting on a protein • kinase activity • cyclic nucleotide-dependent protein kinase activity • protein kinase activity • cAMP-dependent protein kinase activity • transferase activity • enzyme inhibitor activity • protein kinase regulator activity • phosphotransferase activity, alcohol group as acceptor • transferase activity, transferring phosphorus-containing groups • cAMP-dependent protein kinase regulator activity • protein kinase inhibitor activity • molecular function inhibitor activity • molecular function regulator activity • catalytic activity • cAMP-dependent protein kinase inhibitor activity • protein serine/threonine kinase inhibitor activity • kinase inhibitor activity • kinase regulator activity • molecular sequestering activity • protein sequestering activity • sterol binding • oxysterol binding • steroid binding • lipid binding • protein kinase A catalytic subunit binding • protein kinase A binding • kinase binding • enzyme binding • protein kinase binding • electron transport chain • metabolic process • cellular process • generation of precursor metabolites and energy • cellular response to stimulus • response to sterol • response to stimulus • response to lipid • response to alcohol • response to oxygen-containing compound • response to cholesterol • cellular response to oxygen-containing compound • cellular response to chemical stimulus • cellular response to alcohol
Gene Ontology	Biological Process	• electron transport chain • metabolic process • cellular process • generation of precursor metabolites and energy • cellular response to stimulus • response to sterol • response to stimulus • response to lipid • response to alcohol • response to oxygen-containing compound • response to cholesterol • cellular response to oxygen-containing compound • cellular response to chemical stimulus • cellular response to alcohol • response to chemical • cellular response to lipid • cellular response to sterol • cellular response to cholesterol • developmental process • cellular developmental process • cell differentiation • cell fate specification • cell fate commitment • neuroblast proliferation • multicellular organismal process • cell population proliferation • nervous system development • generation of neurons • neurogenesis • multicellular organism development • anatomical structure development • neural precursor cell proliferation • system development • pattern specification process • digestive system development • tube development • midgut development • digestive tract development • regulation of protein stability • biological regulation • regulation of biological quality • protein stabilization • central nervous system development • multicellular organismal-level homeostasis • homeostatic process • homeostasis of number of cells within a tissue • anatomical structure homeostasis • tissue homeostasis • homeostasis of number of cells • mammary gland epithelial cell differentiation • epithelium development • mammary gland development • gland development • animal organ development • tissue development • epithelial cell differentiation • mammary gland epithelium development • regulation of biological process • signaling • cell-cell signaling • epithelial-mesenchymal cell signaling • cell communication • muscle cell migration • myoblast migration • cell migration • cell motility • regulation of biosynthetic process • regulation of cellular process • positive regulation of biological process • regulation of macromolecule metabolic process • gene expression • macromolecule biosynthetic process • positive regulation of macromolecule biosynthetic process • regulation of gene expression • positive regulation of metabolic process • biosynthetic process • positive regulation of gene expression • positive regulation of biosynthetic process • regulation of macromolecule biosynthetic process • positive regulation of macromolecule metabolic process • macromolecule metabolic process • regulation of metabolic process • positive regulation of cellular process • anatomical structure morphogenesis • pancreas morphogenesis • pancreas development • animal organ morphogenesis • apoptotic process • cell death • programmed cell death • regulation of protein modification process • regulation of protein phosphorylation • negative regulation of biological process • negative regulation of phosphate metabolic process • regulation of primary metabolic process • regulation of phosphate metabolic process • phosphate-containing compound metabolic process • negative regulation of protein modification process • negative regulation of cellular process • protein metabolic process • protein modification process • phosphorus metabolic process • negative regulation of protein metabolic process • negative regulation of macromolecule metabolic process • protein phosphorylation • phosphorylation • regulation of protein metabolic process • negative regulation of metabolic process • primary metabolic process • negative regulation of protein phosphorylation • macromolecule modification • negative regulation of phosphorus metabolic process • regulation of phosphorylation • regulation of phosphorus metabolic process • negative regulation of phosphorylation • cerebellum morphogenesis • cerebellar cortex morphogenesis • head development • hindbrain morphogenesis • brain development • cerebellar cortex development • cerebellum development • metencephalon development • hindbrain development • protein localization • establishment of protein localization • cellular localization • nitrogen compound transport • nucleocytoplasmic transport • transport • nuclear transport • intracellular transport • protein localization to nucleus • establishment of localization • localization • import into nucleus • establishment of protein localization to organelle • protein transport • cellular macromolecule localization • macromolecule localization • protein localization to organelle • establishment of localization in cell • protein import into nucleus • intracellular protein transport • epidermis development • molting cycle process • hair cycle • epidermis morphogenesis • morphogenesis of an epithelium • tissue morphogenesis • skin development • skin epidermis development • hair follicle development • molting cycle • hair cycle process • hair follicle morphogenesis • regulation of localization • regulation of protein localization • positive regulation of nucleocytoplasmic transport • positive regulation of establishment of protein localization • regulation of protein localization to nucleus • positive regulation of protein transport • regulation of protein import into nucleus • positive regulation of intracellular transport • regulation of intracellular transport • regulation of transport • positive regulation of protein localization to nucleus • regulation of establishment of protein localization • positive regulation of protein import into nucleus • regulation of nucleocytoplasmic transport • regulation of protein transport • positive regulation of transport • regulation of cellular localization • positive regulation of protein localization • regulation of intracellular protein transport • positive regulation of intracellular protein transport • embryo development ending in birth or egg hatching • chordate embryonic development • embryo development • in utero embryonic development • forebrain development • pallium development • cerebral cortex development • telencephalon development • astrocyte differentiation • cell development • astrocyte activation • glial cell development • astrocyte development • gliogenesis • response to stress • defense response • cell activation • glial cell differentiation • glial cell activation • inflammatory response • neuroinflammatory response • brain morphogenesis • forebrain morphogenesis • neural tube development • regionalization • dorsal/ventral pattern formation • dorsal/ventral neural tube patterning • neural tube patterning • endocrine system development • type B pancreatic cell development • epithelial cell development • endocrine pancreas development • enteroendocrine cell differentiation • type B pancreatic cell differentiation • RNA metabolic process • negative regulation of RNA biosynthetic process • RNA biosynthetic process • nucleobase-containing compound metabolic process • DNA-templated transcription • nucleic acid biosynthetic process • regulation of RNA metabolic process • transcription by RNA polymerase II • negative regulation of nucleobase-containing compound metabolic process • regulation of nucleobase-containing compound metabolic process • regulation of RNA biosynthetic process • regulation of transcription by RNA polymerase II • negative regulation of DNA-templated transcription • negative regulation of transcription by RNA polymerase II • nucleobase-containing compound biosynthetic process • nucleic acid metabolic process • negative regulation of biosynthetic process • negative regulation of macromolecule biosynthetic process • regulation of DNA-templated transcription • negative regulation of RNA metabolic process • multicellular organism growth • developmental growth • growth • positive regulation of DNA-templated transcription • positive regulation of nucleobase-containing compound metabolic process • positive regulation of transcription by RNA polymerase II • positive regulation of RNA metabolic process • positive regulation of RNA biosynthetic process • heart morphogenesis • embryonic heart tube development • tube morphogenesis • embryonic heart tube morphogenesis • heart looping • determination of bilateral symmetry • epithelial tube morphogenesis • embryonic organ development • determination of left/right symmetry • specification of symmetry • embryonic organ morphogenesis • heart development • embryonic morphogenesis • determination of heart left/right asymmetry • circulatory system development • left/right pattern formation • regulation of somatic stem cell population maintenance • regulation of developmental process • regulation of stem cell population maintenance • stem cell population maintenance • somatic stem cell population maintenance • regulation of multicellular organismal process • maintenance of cell number • ossification • osteoblast differentiation • cell surface receptor signaling pathway • smoothened signaling pathway • signal transduction • myotube cell development • skeletal muscle fiber development • skeletal muscle tissue development • muscle cell differentiation • myotube differentiation • striated muscle tissue development • muscle structure development • skeletal muscle organ development • striated muscle cell development • muscle cell development • muscle tissue development • muscle organ development • striated muscle cell differentiation • cardiac atrium morphogenesis • cardiac chamber morphogenesis • cardiac atrium development • cardiac septum development • cardiac septum morphogenesis • cardiac chamber development • atrial septum morphogenesis • atrial septum development • mesonephric epithelium development • kidney epithelium development • branching morphogenesis of an epithelial tube • nephron tubule morphogenesis • regulation of kidney development • regulation of branching involved in ureteric bud morphogenesis • positive regulation of developmental process • nephron development • regulation of morphogenesis of a branching structure • regulation of animal organ morphogenesis • positive regulation of multicellular organismal process • mesonephric tubule development • renal tubule morphogenesis • nephron morphogenesis • nephron epithelium morphogenesis • nephron tubule development • renal system development • ureteric bud morphogenesis • positive regulation of morphogenesis of an epithelium • branching involved in ureteric bud morphogenesis • renal tubule development • regulation of morphogenesis of an epithelium • regulation of anatomical structure morphogenesis • nephron epithelium development • ureteric bud development • mesonephros development • kidney morphogenesis • morphogenesis of a branching structure • positive regulation of branching involved in ureteric bud morphogenesis • mesonephric tubule morphogenesis • kidney development • morphogenesis of a branching epithelium • odontogenesis of dentin-containing tooth • odontogenesis • negative regulation of programmed cell death • regulation of apoptotic process • regulation of programmed cell death • negative regulation of apoptotic process • ventral midline determination • ventral midline development • central nervous system neuron differentiation • neuron differentiation • positive regulation of cell communication • positive regulation of signal transduction • regulation of signal transduction • positive regulation of response to stimulus • positive regulation of smoothened signaling pathway • regulation of smoothened signaling pathway • regulation of signaling • regulation of response to stimulus • regulation of cell communication • positive regulation of signaling • regulation of cell differentiation • regulation of epithelial cell differentiation • negative regulation of cell differentiation • regulation of multicellular organismal development • negative regulation of epithelial cell differentiation • negative regulation of developmental process • spinal cord dorsal/ventral patterning • spinal cord development • spinal cord patterning • positive regulation of mesenchymal cell proliferation • positive regulation of cell population proliferation • regulation of mesenchymal cell proliferation • regulation of cell population proliferation • mesenchymal cell proliferation • positive regulation of epithelial cell proliferation • regulation of epithelial cell proliferation • epithelial cell proliferation • diencephalon development • thalamus development • stem cell development • neural crest cell differentiation • neural crest cell development • mesenchyme development • mesenchymal cell migration • stem cell differentiation • ameboidal-type cell migration • mesenchymal cell differentiation • neural crest cell migration • commissural neuron axon guidance • axonogenesis • cell projection organization • plasma membrane bounded cell projection morphogenesis • neuron projection development • cell morphogenesis • cellular component organization • cell projection morphogenesis • neuron projection morphogenesis • cellular component organization or biogenesis • plasma membrane bounded cell projection organization • axon guidance • axon development • cell morphogenesis involved in neuron differentiation • neuron projection guidance • neuron development • left/right axis specification • axis specification • regulation of heart morphogenesis • blood vessel morphogenesis • vasculogenesis • vasculature development • blood vessel development • mesenchymal to epithelial transition involved in renal vesicle formation • renal vesicle morphogenesis • metanephric renal vesicle morphogenesis • renal vesicle development • metanephros development • metanephric renal vesicle formation • metanephros morphogenesis • metanephric nephron development • mesenchymal to epithelial transition involved in metanephric renal vesicle formation • mesenchymal to epithelial transition involved in metanephros morphogenesis • epithelial cell differentiation involved in kidney development • mesenchymal to epithelial transition • metanephric nephron morphogenesis • cell differentiation involved in metanephros development • cell differentiation involved in kidney development • anatomical structure formation involved in morphogenesis • renal vesicle formation • positive regulation of locomotion • regulation of cell motility • positive regulation of cell migration • regulation of locomotion • positive regulation of cell motility • regulation of cell migration • locomotion • regulation of growth • regulation of developmental growth • positive regulation of organ growth • organ growth • positive regulation of growth • regulation of organ growth • positive regulation of developmental growth • regulation of multicellular organism growth • positive regulation of multicellular organism growth • dentate gyrus development • hippocampus development • limbic system development • smooth muscle tissue development • regulation of molecular function • regulation of DNA binding • regulation of binding • negative regulation of binding • negative regulation of molecular function • negative regulation of DNA binding • response to inositol • negative regulation of gene expression • regulation of hair cycle • regulation of hair follicle development • negative regulation of hair follicle development • negative regulation of multicellular organismal process • detection of stimulus • contact inhibition • detection of cell density • detection of biotic stimulus • response to biotic stimulus • lateral mesoderm development • determination of left/right asymmetry in lateral mesoderm • mesoderm development • dopaminergic neuron differentiation • positive regulation of nervous system development • regulation of neuroblast proliferation • regulation of neurogenesis • regulation of cell development • regulation of nervous system development • positive regulation of cell differentiation • positive regulation of neurogenesis • regulation of neural precursor cell proliferation • positive regulation of cell development • positive regulation of neural precursor cell proliferation • positive regulation of neuroblast proliferation • anterior/posterior pattern specification • somite development • cellular anatomical structure • periplasmic space • extracellular exosome • membrane-bounded organelle • extracellular vesicle • extracellular organelle • extracellular region • organelle • extracellular space • vesicle • extracellular membrane-bounded organelle • cell projection • ciliary tip • cilium
Gene Ontology	Cellular Component	• cellular anatomical structure • periplasmic space • extracellular exosome • membrane-bounded organelle • extracellular vesicle • extracellular organelle • extracellular region • organelle • extracellular space • vesicle • extracellular membrane-bounded organelle • cell projection • ciliary tip • cilium • plasma membrane bounded cell projection • somatodendritic compartment • dendrite • dendritic tree • neuron projection • intracellular anatomical structure • membrane • intracellular vesicle • intracellular membrane-bounded organelle • intracellular organelle • cytoplasmic vesicle membrane • bounding membrane of organelle • cytoplasmic vesicle • vesicle membrane • endocytic vesicle membrane • cytoplasm • organelle membrane • endocytic vesicle • Golgi apparatus • endomembrane system • endoplasmic reticulum-Golgi intermediate compartment • non-motile cilium • 9+0 non-motile cilium • microtubule organizing center • cytoskeleton • membraneless organelle • centriole • intracellular membraneless organelle • microtubule cytoskeleton • cell periphery • plasma membrane • ciliary membrane • plasma membrane region • cell projection membrane • endosome • late endosome • endoplasmic reticulum
SCOP2	Domain Identifier	• Cytochromes • G protein-coupled receptor-like
SCOP2	Family Identifier	• Cytochromes • G protein-coupled receptor-like
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	CY8
PDB Residues	L:L:?1
Environment Details	Open EMBL-EBI Page
Code	CY8
Name	Cyclopamine
Synonyms	(3alpha,8alpha,14beta,22S,23R)-17,23-epoxyveratraman-3-ol
Identifier
Formula	C27 H41 N O2
Molecular Weight	411.62
SMILES
PubChem	442972
Formal Charge	0
Total Atoms	71
Total Chiral Atoms	10
Total Bonds	76
Total Aromatic Bonds	0


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	Q99835
Sequence	>4O9R_Chain_R Q C E V P L V R T D N P K S W Y E D V E G C G I Q C Q N P L F T E A E H Q D M H S Y I A A F G A V T G L C T L F T L A T F V A D W R N S N R Y P A V I L F Y V N A C F F V G S I G W L A Q F M D G A R R E I V C R A D G T M R L G E P T S N E T L S C V I I F V I V Y Y A L M A G V V W F V V L T Y A W H T S F K G K T S Y F H L L T W S L P F V L T V A I L A V A Q V D G D S V S G I C F V G Y K N Y R Y R A G F V L A P I G L V L I V G G Y F L I R G V M T L F S I K S N H A A S K I N E T M L R L G I F G F L A F G F V L I T F S C H F Y D F F N Q A E W E R S F R D Y V L C Q A N V T I P D C E I K N R P S L L V E K I N L F A M F G T G I A M S T W V W T K A T L L I W R R T W C R Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	8CXO	F	Protein	Frizzled	SMO	Mus musculus	-	-	-	3.7	2022-08-03	10.1038/s41467-022-32125-2
	7ZI0	F	Protein	Frizzled	SMO	Homo sapiens	SAG	Cholesterol	-	3	2022-06-15	10.1126/sciadv.abm5563
	6XBM	F	Protein	Frizzled	SMO	Homo sapiens	-	25(S)-Epoxycholesterol	Gi1/β1/γ2	3.14	2020-09-30	10.1038/s41589-020-0646-2
	6XBM (No Gprot)	F	Protein	Frizzled	SMO	Homo sapiens	-	25(S)-Epoxycholesterol		3.14	2020-09-30	10.1038/s41589-020-0646-2
	6XBL	F	Protein	Frizzled	SMO	Homo sapiens	SAG	Cholesterol	Gi1/β1/γ2	3.96	2020-09-30	10.1038/s41589-020-0646-2
	6XBL (No Gprot)	F	Protein	Frizzled	SMO	Homo sapiens	SAG	Cholesterol		3.96	2020-09-30	10.1038/s41589-020-0646-2
	6XBK	F	Protein	Frizzled	SMO	Homo sapiens	-	Cholesterol	Gi1/β1/γ2	3.24	2020-09-30	10.1038/s41589-020-0646-2
	6XBK (No Gprot)	F	Protein	Frizzled	SMO	Homo sapiens	-	Cholesterol		3.24	2020-09-30	10.1038/s41589-020-0646-2
	6XBJ	F	Protein	Frizzled	SMO	Homo sapiens	-	Cholesterol	Gi1/β1/γ2	3.88	2020-09-30	10.1038/s41589-020-0646-2
	6XBJ (No Gprot)	F	Protein	Frizzled	SMO	Homo sapiens	-	Cholesterol		3.88	2020-09-30	10.1038/s41589-020-0646-2
	6O3C	F	Protein	Frizzled	SMO	Mus musculus	SAG21k	Cholesterol	-	2.8	2019-07-03	10.1038/s41586-019-1355-4
	6OT0	F	Protein	Frizzled	SMO	Homo sapiens	-	25(S)-Epoxycholesterol	Gi1/β1/γ2	3.84	2019-06-12	10.1038/s41586-019-1286-0
	6OT0 (No Gprot)	F	Protein	Frizzled	SMO	Homo sapiens	-	25(S)-Epoxycholesterol		3.84	2019-06-12	10.1038/s41586-019-1286-0
	6D35	F	Protein	Frizzled	SMO	Xenopus laevis	-	Cholesterol	-	3.9	2018-05-23	10.1016/j.cell.2018.04.029
	6D32	F	Protein	Frizzled	SMO	Xenopus laevis	Cyclopamine	Cyclopamine	-	3.75	2018-05-23	10.1016/j.cell.2018.04.029
	5V57	F	Protein	Frizzled	SMO	Homo sapiens	TC114	-	-	3	2017-05-24	10.1038/ncomms15383
	5V56	F	Protein	Frizzled	SMO	Homo sapiens	TC114	-	-	2.9	2017-05-24	10.1038/ncomms15383
	5L7I	F	Protein	Frizzled	SMO	Homo sapiens	Vismodegib	-	-	3.3	2016-07-20	10.1038/nature18934
	5L7D	F	Protein	Frizzled	SMO	Homo sapiens	-	Cholesterol	-	3.2	2016-07-20	10.1038/nature18934
	4QIN	F	Protein	Frizzled	SMO	Homo sapiens	SAG1.5	-	-	2.6	2014-07-23	10.1038/ncomms5355
	4QIM	F	Protein	Frizzled	SMO	Homo sapiens	ANTA XV	-	-	2.61	2014-07-23	10.1038/ncomms5355
	4O9R	F	Protein	Frizzled	SMO	Homo sapiens	Cyclopamine	-	-	3.2	2014-03-05	10.1038/ncomms4309
	4N4W	F	Protein	Frizzled	SMO	Homo sapiens	-	SANT-1	-	2.8	2014-01-22	10.1038/ncomms5355
	4JKV	F	Protein	Frizzled	SMO	Homo sapiens	Taladegib	-	-	2.45	2013-04-24	10.1038/nature12167
	4JKV (Multimeric)	F	Protein	Frizzled	SMO	Homo sapiens	Taladegib	-		2.45	2013-04-24	10.1038/nature12167

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