psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:C64	R:R:P175	5.65	No	No	0	7	5
2	R:R:C178	R:R:C64	7.28	No	No	7	6	7
3	R:R:G65	R:R:R138	7.51	No	No	0	4	4
4	R:R:L141	R:R:R66	7.29	Yes	No	0	7	6
5	R:R:C134	R:R:C70	7.28	No	No	0	9	9
6	R:R:L73	R:R:N76	4.12	No	No	0	7	4
7	R:R:Q99	R:R:Y75	14.65	No	No	0	9	3
8	R:R:H103	R:R:Y75	20.69	No	No	0	5	3
9	R:R:L83	R:R:N76	6.87	No	No	0	7	4
10	R:R:C127	R:R:C78	7.28	No	No	0	9	9
11	R:R:C78	R:R:F187	5.59	No	Yes	0	9	6
12	R:R:L106	R:R:L79	4.15	No	No	0	8	5
13	R:R:L79	R:R:S110	4.5	No	No	0	5	5
14	R:R:F187	R:R:S81	13.21	Yes	No	0	6	5
15	R:R:I185	R:R:P84	6.77	No	No	0	4	4
16	R:R:K133	R:R:Y85	17.91	No	No	0	6	9
17	R:R:E181	R:R:Y85	17.96	No	No	0	5	9
18	R:R:A87	R:R:K133	4.82	No	No	0	4	6
19	R:R:M131	R:R:T88	9.03	No	No	0	5	9
20	R:R:P132	R:R:S89	3.56	No	No	0	9	8
21	R:R:L141	R:R:L92	8.3	Yes	No	0	7	8
22	R:R:D95	R:R:S96	7.36	Yes	Yes	0	5	6
23	R:R:D95	R:R:K105	8.3	Yes	No	3	5	4
24	R:R:D95	R:R:Y130	11.49	Yes	Yes	3	5	7
25	R:R:D95	R:R:F166	26.27	Yes	Yes	3	5	6
26	R:R:E101	R:R:S96	5.75	No	Yes	0	5	6
27	R:R:D97	R:R:E101	5.2	No	No	0	3	5
28	R:R:E100	R:R:Q99	3.82	No	No	0	4	9
29	R:R:H103	R:R:L106	5.14	No	No	0	5	8
30	R:R:H103	R:R:V107	6.92	No	No	0	5	4
31	R:R:K105	R:R:W109	4.64	No	Yes	3	4	7
32	R:R:K105	R:R:Y130	5.97	No	Yes	3	4	7
33	R:R:W109	R:R:Y130	6.75	Yes	Yes	3	7	7
34	R:R:V157	R:R:W109	6.13	No	Yes	0	6	7
35	R:R:Q192	R:R:R113	21.03	No	No	4	4	5
36	R:R:E194	R:R:R113	5.82	Yes	No	4	6	5
37	R:R:N114	R:R:Q192	6.6	No	No	4	5	4
38	R:R:E194	R:R:N114	7.89	Yes	No	4	6	5
39	R:R:P153	R:R:R117	4.32	No	Yes	0	6	5
40	R:R:R117	R:R:W206	8	Yes	Yes	5	5	4
41	R:R:E211	R:R:R117	11.63	No	Yes	5	5	5
42	R:R:G212	R:R:R117	4.5	No	Yes	5	7	5
43	R:R:C118	R:R:C154	7.28	No	No	0	9	9
44	R:R:Q123	R:R:W119	29.57	No	No	0	8	9
45	R:R:S190	R:R:W119	4.94	No	No	0	6	9
46	R:R:I122	R:R:L125	5.71	Yes	No	2	7	7
47	R:R:I122	R:R:L126	8.56	Yes	No	0	7	9
48	R:R:I122	R:R:T150	4.56	Yes	Yes	2	7	7
49	R:R:F187	R:R:Q123	5.86	Yes	No	0	6	8
50	R:R:L125	R:R:L146	6.92	No	Yes	0	7	6
51	R:R:L125	R:R:T150	4.42	No	Yes	2	7	7
52	R:R:F166	R:R:Y130	8.25	Yes	Yes	3	6	7
53	R:R:E135	R:R:R138	16.28	No	No	0	6	4
54	R:R:E140	R:R:R138	6.98	No	No	0	5	4
55	R:R:F174	R:R:P142	17.34	No	No	0	8	8
56	R:R:S143	R:R:T145	4.8	No	No	9	8	6
57	R:R:N180	R:R:S143	8.94	No	No	9	5	8
58	R:R:Q148	R:R:R144	5.84	No	Yes	0	5	6
59	R:R:C169	R:R:R144	4.18	No	Yes	8	9	6
60	R:R:F174	R:R:R144	5.34	No	Yes	8	8	6
61	R:R:E176	R:R:R144	13.96	No	Yes	0	4	6
62	R:R:N180	R:R:T145	4.39	No	No	9	5	6
63	R:R:L146	R:R:N180	4.12	Yes	No	0	6	5
64	R:R:L146	R:R:V182	4.47	Yes	No	0	6	4
65	R:R:C147	R:R:R151	8.36	No	Yes	0	9	5
66	R:R:C147	R:R:C169	7.28	No	No	0	9	9
67	R:R:R151	R:R:T150	3.88	Yes	Yes	2	5	7
68	R:R:R151	R:R:W163	6	Yes	Yes	2	5	8
69	R:R:R151	R:R:R168	8.53	Yes	No	2	5	4
70	R:R:G152	R:R:P153	4.06	No	No	0	4	6
71	R:R:A155	R:R:E158	4.53	No	No	0	5	7
72	R:R:V157	R:R:W163	23.29	No	Yes	0	6	8
73	R:R:E158	R:R:R159	3.49	No	No	0	7	5
74	R:R:E158	R:R:W163	4.36	No	Yes	0	7	8
75	R:R:R159	R:R:R485	6.4	No	Yes	0	5	5
76	R:R:E160	R:R:R161	4.65	No	No	0	4	5
77	R:R:E160	R:R:L489	13.25	No	No	0	4	4
78	R:R:L167	R:R:W163	12.53	No	Yes	0	7	8
79	R:R:R168	R:R:W163	11	No	Yes	2	4	8
80	R:R:F166	R:R:P164	8.67	Yes	No	0	6	9
81	R:R:D165	R:R:R173	5.96	No	No	0	4	4
82	R:R:F166	R:R:L167	17.05	Yes	No	0	6	7
83	R:R:C169	R:R:F174	9.78	No	No	8	9	8
84	R:R:P171	R:R:T170	3.5	No	No	0	3	6
85	R:R:D172	R:R:T170	10.12	No	No	0	4	6
86	R:R:E176	R:R:P171	4.72	No	No	0	4	3
87	R:R:E181	R:R:N184	5.26	No	No	0	5	3
88	R:R:I185	R:R:N184	7.08	No	No	0	4	3
89	R:R:F187	R:R:I185	7.54	Yes	No	0	6	4
90	R:R:K186	R:R:N188	6.99	No	No	0	4	8
91	R:R:E194	R:R:Q192	5.1	Yes	No	4	6	4
92	R:R:C193	R:R:R199	4.18	No	No	0	9	4
93	R:R:C193	R:R:C213	7.28	No	No	0	9	9
94	R:R:P196	R:R:V195	5.3	Yes	No	0	7	4
95	R:R:L197	R:R:P196	4.93	No	Yes	0	9	7
96	R:R:C213	R:R:L197	6.35	No	No	0	9	9
97	R:R:T200	R:R:W206	7.28	No	Yes	0	6	4
98	R:R:D298	R:R:T200	5.78	No	No	0	7	6
99	R:R:K204	R:R:N202	12.59	No	No	0	3	5
100	R:R:N202	R:R:S205	4.47	No	No	0	5	7
101	R:R:K204	R:R:T307	4.5	No	No	0	3	6
102	R:R:R296	R:R:S205	9.22	Yes	No	0	6	7
103	R:R:E211	R:R:W206	4.36	No	Yes	5	5	4
104	R:R:G212	R:R:W206	5.63	No	Yes	5	7	4
105	R:R:D209	R:R:Y207	8.05	No	Yes	10	4	7
106	R:R:V210	R:R:Y207	5.05	No	Yes	0	5	7
107	R:R:I215	R:R:Y207	10.88	No	Yes	0	5	7
108	R:R:R485	R:R:Y207	5.14	Yes	Yes	10	5	7
109	R:R:D209	R:R:R485	17.87	No	Yes	10	4	5
110	R:R:F484	R:R:I215	5.02	Yes	No	0	6	5
111	R:R:P220	R:R:Q216	6.32	No	No	0	8	7
112	R:R:C217	R:R:C295	7.28	No	No	11	9	9
113	R:R:H227	R:R:Q218	4.95	Yes	No	0	7	5
114	R:R:N219	R:R:P220	6.52	Yes	No	0	7	8
115	R:R:L221	R:R:N219	9.61	No	Yes	0	6	7
116	R:R:N219	R:R:R384	3.62	Yes	Yes	0	7	8
117	R:R:N219	R:R:S385	4.47	Yes	No	0	7	7
118	R:R:F484	R:R:P220	7.22	Yes	No	0	6	8
119	R:R:F222	R:R:L221	3.65	Yes	No	0	6	6
120	R:R:F484	R:R:L221	3.65	Yes	No	0	6	6
121	R:R:E226	R:R:F222	5.83	No	Yes	0	8	6
122	R:R:F222	R:R:R384	4.28	Yes	Yes	1	6	8
123	R:R:F222	R:R:V386	5.24	Yes	Yes	1	6	5
124	R:R:F222	R:R:P513	8.67	Yes	No	0	6	8
125	R:R:F222	R:R:L515	4.87	Yes	No	0	6	5
126	R:R:E226	R:R:T223	7.06	No	No	0	8	5
127	R:R:E226	R:R:R512	10.47	No	No	0	8	6
128	R:R:H227	R:R:H231	4.78	Yes	Yes	0	7	7
129	R:R:H227	R:R:S385	6.97	Yes	No	0	7	7
130	R:R:H227	R:R:V386	9.69	Yes	Yes	0	7	5
131	R:R:D229	R:R:K519	4.15	No	No	0	6	7
132	R:R:M230	R:R:V386	4.56	No	Yes	0	7	5
133	R:R:L515	R:R:M230	4.24	No	No	0	5	7
134	R:R:F285	R:R:H231	4.53	Yes	Yes	0	8	7
135	R:R:H231	R:R:R290	23.7	Yes	No	0	7	9
136	R:R:F237	R:R:Y233	6.19	No	No	0	4	6
137	R:R:K519	R:R:Y233	8.36	No	No	0	7	6
138	R:R:L522	R:R:Y233	7.03	No	No	0	7	6
139	R:R:I234	R:R:W281	4.7	No	Yes	1	7	7
140	R:R:I234	R:R:L522	5.71	No	No	0	7	7
141	R:R:F526	R:R:I234	3.77	Yes	No	1	9	7
142	R:R:A235	R:R:F285	8.32	No	Yes	0	5	8
143	R:R:F237	R:R:F523	5.36	No	No	0	4	6
144	R:R:F237	R:R:F526	8.57	No	Yes	0	4	9
145	R:R:F526	R:R:G238	4.52	Yes	No	0	9	7
146	R:R:F526	R:R:T241	9.08	Yes	No	0	9	7
147	R:R:I530	R:R:T241	4.56	No	No	0	7	7
148	R:R:G242	R:R:S278	3.71	No	No	0	4	8
149	R:R:C244	R:R:S533	5.16	No	No	0	6	9
150	R:R:F275	R:R:T245	5.19	Yes	No	0	5	8
151	R:R:F247	R:R:T251	6.49	No	No	0	8	9
152	R:R:F247	R:R:W537	5.01	No	No	0	8	8
153	R:R:N271	R:R:T248	14.62	No	No	12	9	8
154	R:R:S533	R:R:T248	6.4	No	No	12	9	8
155	R:R:T248	R:R:V536	6.35	No	No	0	8	8
156	R:R:A272	R:R:L249	4.73	No	No	0	4	6
157	R:R:F275	R:R:L249	3.65	Yes	No	0	5	6
158	R:R:F252	R:R:S259	7.93	No	No	0	9	8
159	R:R:F252	R:R:F268	13.93	No	Yes	0	9	8
160	R:R:D255	R:R:N258	10.77	No	No	0	8	8
161	R:R:R257	R:R:W256	5	No	No	13	5	7
162	R:R:N260	R:R:W256	10.17	No	No	13	7	7
163	R:R:F268	R:R:W256	9.02	Yes	No	0	8	7
164	R:R:N260	R:R:R257	15.67	No	No	13	7	5
165	R:R:R261	R:R:S259	5.27	No	No	0	7	8
166	R:R:N260	R:R:V265	7.39	No	No	0	7	8
167	R:R:A264	R:R:R261	6.91	No	No	0	9	7
168	R:R:I266	R:R:Y262	4.84	No	Yes	0	8	9
169	R:R:T357	R:R:Y262	14.98	No	Yes	0	6	9
170	R:R:F360	R:R:Y262	6.19	Yes	Yes	0	9	9
171	R:R:H361	R:R:Y262	7.62	Yes	Yes	0	9	9
172	R:R:V265	R:R:Y269	5.05	No	Yes	0	8	8
173	R:R:I266	R:R:W331	5.87	No	Yes	0	8	9
174	R:R:I266	R:R:L335	5.71	No	No	0	8	8
175	R:R:L267	R:R:N271	4.12	No	No	0	8	9
176	R:R:L267	R:R:W535	7.97	No	Yes	0	8	9
177	R:R:F268	R:R:Y269	5.16	Yes	Yes	0	8	8
178	R:R:W331	R:R:Y269	13.5	Yes	Yes	6	9	8
179	R:R:H361	R:R:Y269	7.62	Yes	Yes	6	9	8
180	R:R:M532	R:R:V270	4.56	No	No	0	8	8
181	R:R:N271	R:R:S533	4.47	No	No	12	9	9
182	R:R:C273	R:R:G328	3.92	No	No	0	9	8
183	R:R:F274	R:R:G328	4.52	No	No	0	9	8
184	R:R:F274	R:R:G529	7.53	No	No	0	9	9
185	R:R:V321	R:R:W281	6.13	No	Yes	0	8	7
186	R:R:I389	R:R:W281	7.05	No	Yes	0	9	7
187	R:R:M525	R:R:W281	6.98	Yes	Yes	1	5	7
188	R:R:F526	R:R:W281	9.02	Yes	Yes	1	9	7
189	R:R:W281	W:W:?1	4.54	Yes	Yes	1	7	0
190	R:R:F285	R:R:L282	3.65	Yes	No	0	8	7
191	R:R:F285	R:R:Q284	16.4	Yes	No	0	8	9
192	R:R:Q284	R:R:R290	8.18	No	No	0	9	9
193	R:R:G388	R:R:Q284	4.93	No	No	0	9	9
194	R:R:D287	R:R:G288	5.03	No	No	0	5	6
195	R:R:I293	R:R:I317	5.89	No	No	0	8	7
196	R:R:D298	R:R:R296	3.57	No	Yes	0	7	6
197	R:R:R296	R:R:R302	4.26	Yes	Yes	0	6	6
198	R:R:E310	R:R:R296	12.79	No	Yes	0	8	6
199	R:R:A297	R:R:E310	4.53	No	No	0	5	8
200	R:R:D298	R:R:T300	7.23	No	No	0	7	7
201	R:R:E305	R:R:R302	12.79	Yes	Yes	14	7	6
202	R:R:C314	R:R:R302	6.96	Yes	Yes	14	9	6
203	R:R:K395	R:R:L303	4.23	No	No	0	3	3
204	R:R:E305	R:R:P306	4.72	Yes	No	0	7	5
205	R:R:C314	R:R:E305	6.08	Yes	Yes	14	9	7
206	R:R:E305	R:R:V315	8.56	Yes	Yes	0	7	7
207	R:R:E305	R:R:V381	7.13	Yes	No	0	7	8
208	R:R:E310	R:R:N309	5.26	No	No	0	8	6
209	R:R:S313	R:R:T311	6.4	No	No	0	7	7
210	R:R:L312	R:R:V315	4.47	No	Yes	0	7	7
211	R:R:C314	R:R:C390	7.28	Yes	No	0	9	9
212	R:R:F318	R:R:Y322	8.25	No	Yes	0	9	9
213	R:R:F318	R:R:I375	3.77	No	No	0	9	7
214	R:R:F318	R:R:V381	19.66	No	No	0	9	8
215	R:R:T372	R:R:V319	6.35	No	No	0	9	7
216	R:R:F391	R:R:V321	3.93	Yes	No	0	8	8
217	R:R:M326	R:R:Y322	5.99	No	Yes	1	8	9
218	R:R:L371	R:R:Y322	7.03	No	Yes	1	8	9
219	R:R:T372	R:R:Y322	3.75	No	Yes	0	9	9
220	R:R:F391	R:R:Y322	5.16	Yes	Yes	1	8	9
221	R:R:W365	R:R:Y323	6.75	No	Yes	0	9	8
222	R:R:P368	R:R:Y323	4.17	No	Yes	0	9	8
223	R:R:L325	R:R:M525	4.24	No	Yes	1	5	5
224	R:R:L325	W:W:?1	12.42	No	Yes	1	5	0
225	R:R:L371	R:R:M326	4.24	No	No	1	8	8
226	R:R:M326	R:R:P407	6.71	No	No	0	8	9
227	R:R:I408	R:R:V329	4.61	No	No	1	7	6
228	R:R:V329	R:R:V411	4.81	No	No	0	6	5
229	R:R:V329	W:W:?1	5.94	No	Yes	1	6	0
230	R:R:T364	R:R:V330	4.76	No	No	0	9	6
231	R:R:H361	R:R:W331	6.35	Yes	Yes	6	9	9
232	R:R:T364	R:R:W331	26.68	No	Yes	0	9	9
233	R:R:W331	R:R:W365	13.12	Yes	No	6	9	9
234	R:R:F332	R:R:T336	7.78	Yes	No	0	9	7
235	R:R:F332	R:R:F455	6.43	Yes	Yes	1	9	8
236	R:R:F332	R:R:M532	9.95	Yes	No	1	9	8
237	R:R:F332	W:W:?1	3.64	Yes	Yes	1	9	0
238	R:R:V333	R:R:V411	4.81	No	No	0	9	5
239	R:R:F360	R:R:V334	9.18	Yes	No	0	9	7
240	R:R:L335	R:R:W339	21.64	No	Yes	0	8	9
241	R:R:L419	R:R:T336	4.42	No	No	0	7	7
242	R:R:T341	R:R:Y337	12.48	No	Yes	0	6	7
243	R:R:F360	R:R:Y337	4.13	Yes	Yes	0	9	7
244	R:R:F418	R:R:Y337	10.32	No	Yes	0	8	7
245	R:R:F343	R:R:W339	6.01	No	Yes	0	9	9
246	R:R:L452	R:R:W339	4.56	No	Yes	0	8	9
247	R:R:W339	R:R:W535	8.43	Yes	Yes	0	9	9
248	R:R:F418	R:R:H340	7.92	No	Yes	0	8	7
249	R:R:H340	R:R:R421	7.9	Yes	No	0	7	7
250	R:R:P352	R:R:T341	3.5	Yes	No	0	7	6
251	R:R:F343	R:R:L426	8.53	No	No	0	9	9
252	R:R:I429	R:R:L346	7.14	No	No	0	7	6
253	R:R:G347	R:R:T348	3.64	No	No	0	7	7
254	R:R:P352	R:R:Y350	9.74	Yes	No	0	7	7
255	R:R:Q351	R:R:S354	4.33	No	No	0	7	7
256	R:R:G355	R:R:S354	3.71	No	No	0	6	7
257	R:R:H361	R:R:W365	8.46	Yes	No	6	9	9
258	R:R:F403	R:R:L371	3.65	No	No	0	8	8
259	R:R:I375	R:R:V392	7.68	No	No	0	7	9
260	R:R:F403	R:R:I375	13.82	No	No	0	8	7
261	R:R:V378	R:R:Y399	5.05	No	No	0	5	5
262	R:R:N396	R:R:Q380	11.88	No	No	15	7	7
263	R:R:Q380	R:R:Y399	21.42	No	No	15	7	5
264	R:R:D382	R:R:Y394	12.64	No	Yes	0	9	5
265	R:R:C390	R:R:G383	3.92	No	No	0	9	8
266	R:R:R384	R:R:V386	7.85	Yes	Yes	1	8	5
267	R:R:R384	R:R:S387	5.27	Yes	No	0	8	8
268	R:R:R384	R:R:Y394	10.29	Yes	Yes	1	8	5
269	R:R:F391	R:R:Y394	4.13	Yes	Yes	1	8	5
270	R:R:F391	W:W:?1	3.64	Yes	Yes	1	8	0
271	R:R:Y394	W:W:?1	7.01	Yes	Yes	1	5	0
272	R:R:N396	R:R:Y399	6.98	No	No	15	7	5
273	R:R:R398	R:R:Y397	15.43	No	No	0	1	3
274	R:R:D473	R:R:R400	8.34	No	No	0	8	9
275	R:R:A401	R:R:F474	4.16	No	Yes	0	6	6
276	R:R:V404	W:W:?1	8.91	No	Yes	0	7	0
277	R:R:F467	R:R:L405	12.18	No	No	0	7	8
278	R:R:H470	R:R:L405	9	Yes	No	0	7	8
279	R:R:I408	W:W:?1	11.39	No	Yes	1	7	0
280	R:R:F460	R:R:L412	3.65	No	No	0	5	7
281	R:R:L412	R:R:V463	7.45	No	No	0	7	7
282	R:R:F418	R:R:Y417	6.19	No	No	0	8	5
283	R:R:L419	R:R:L452	5.54	No	No	0	7	8
284	R:R:I420	R:R:M424	4.37	No	No	0	5	5
285	R:R:M424	R:R:R421	4.96	No	No	0	5	7
286	R:R:G422	R:R:T425	3.64	No	No	0	8	7
287	R:R:L426	R:R:M449	4.24	No	Yes	0	9	9
288	R:R:F427	R:R:M449	8.71	No	Yes	0	7	9
289	R:R:H433	R:R:P434	4.58	No	No	0	8	7
290	R:R:H433	R:R:L437	7.71	No	No	0	8	6
291	R:R:K440	R:R:K444	5.75	No	No	0	6	9
292	R:R:M449	R:R:N446	4.21	Yes	No	0	9	7
293	R:R:I454	R:R:L450	7.14	No	No	0	6	6
294	R:R:R451	R:R:W535	5	No	Yes	0	9	9
295	R:R:F455	R:R:M532	4.98	Yes	No	1	8	8
296	R:R:F455	R:R:W535	16.04	Yes	Yes	0	8	9
297	R:R:F462	R:R:L458	9.74	Yes	No	0	7	6
298	R:R:F462	R:R:G527	4.52	Yes	No	0	7	5
299	R:R:F462	R:R:T528	5.19	Yes	No	0	7	7
300	R:R:V463	W:W:?1	4.46	No	Yes	0	7	0
301	R:R:H470	R:R:T466	6.85	Yes	No	1	7	8
302	R:R:T466	W:W:?1	14.7	No	Yes	1	8	0
303	R:R:C469	R:R:N521	11.02	No	No	0	7	8
304	R:R:H470	R:R:N521	6.38	Yes	No	1	7	8
305	R:R:H470	W:W:?1	19.23	Yes	Yes	1	7	0
306	R:R:N476	R:R:Y472	4.65	No	No	0	6	7
307	R:R:V517	R:R:Y472	11.36	No	No	0	6	7
308	R:R:D473	R:R:W480	4.47	No	Yes	0	8	9
309	R:R:E479	R:R:N476	6.57	No	No	0	2	6
310	R:R:N476	R:R:W480	22.6	No	Yes	0	6	9
311	R:R:E481	R:R:Q477	6.37	No	No	0	5	6
312	R:R:E479	R:R:N511	5.26	No	No	0	2	4
313	R:R:N511	R:R:W480	6.78	No	Yes	0	4	9
314	R:R:P513	R:R:W480	28.38	No	Yes	0	8	9
315	R:R:D486	R:R:R482	7.15	No	No	0	4	3
316	R:R:Q491	R:R:Y487	7.89	Yes	No	0	4	4
317	R:R:C490	R:R:C507	7.28	No	No	0	9	9
318	R:R:I509	R:R:R512	8.77	No	No	0	4	6
319	R:R:K510	R:R:N511	6.99	No	No	0	4	4
320	R:R:L516	R:R:S514	4.5	No	No	0	4	7
321	R:R:N521	W:W:?1	5.48	No	Yes	1	8	0
322	R:R:F526	R:R:M525	3.73	Yes	Yes	1	9	5
323	R:R:M525	W:W:?1	14.1	Yes	Yes	1	5	0
324	R:R:T528	W:W:?1	22.05	No	Yes	0	7	0
325	R:R:T534	R:R:W537	6.06	No	No	0	7	8
326	R:R:C70	R:R:S89	3.44	No	No	0	9	8
327	R:R:A102	R:R:S96	3.42	No	Yes	0	7	6
328	R:R:L112	R:R:W119	3.42	No	No	0	8	9
329	R:R:A120	R:R:S190	3.42	No	No	0	4	6
330	R:R:A68	R:R:V139	3.39	No	No	0	5	7
331	R:R:F474	R:R:H470	3.39	Yes	Yes	0	6	7
332	R:R:L83	R:R:P84	3.28	No	No	0	7	4
333	R:R:L141	R:R:P175	3.28	Yes	No	0	7	5
334	R:R:L367	R:R:P368	3.28	No	No	0	5	9
335	R:R:C314	R:R:I293	3.27	Yes	No	0	9	8
336	R:R:C469	R:R:I520	3.27	No	No	0	7	5
337	R:R:A283	R:R:I317	3.25	No	No	0	5	7
338	R:R:A524	R:R:I465	3.25	No	No	0	7	5
339	R:R:S89	R:R:V139	3.23	No	No	0	8	7
340	R:R:A289	R:R:M286	3.22	No	No	0	7	4
341	R:R:F471	R:R:F474	3.22	No	Yes	0	4	6
342	R:R:F166	R:R:R173	3.21	Yes	No	0	6	4
343	R:R:V333	R:R:V414	3.21	No	No	0	9	5
344	R:R:S96	R:R:T90	3.2	Yes	No	0	6	5
345	R:R:G435	R:R:H433	3.18	No	No	0	5	8
346	R:R:T150	R:R:V121	3.17	Yes	No	0	7	7
347	R:R:T251	R:R:V536	3.17	No	No	0	9	8
348	R:R:K444	R:R:S443	3.06	No	No	0	9	6
349	R:R:K510	R:R:S483	3.06	No	No	0	4	7
350	R:R:H63	R:R:P175	3.05	No	No	0	3	5
351	R:R:M301	R:R:T300	3.01	No	No	0	4	7
352	R:R:G191	R:R:R199	3	No	No	0	5	4
353	R:R:L141	R:R:V139	2.98	Yes	No	0	7	7
354	R:R:L376	R:R:V315	2.98	No	Yes	0	8	7
355	R:R:L452	R:R:V423	2.98	No	No	0	8	7
356	R:R:L73	R:R:T88	2.95	No	No	0	7	9
357	R:R:I429	R:R:I445	2.94	No	No	0	7	9
358	R:R:K395	R:R:M301	2.88	No	No	0	3	4
359	R:R:Q183	R:R:V182	2.87	No	No	0	5	4
360	R:R:Q216	R:R:V198	2.87	No	No	0	7	6
361	R:R:I122	R:R:L112	2.85	Yes	No	0	7	8
362	R:R:P263	R:R:Y262	2.78	No	Yes	0	9	9
363	R:R:A338	R:R:F360	2.77	No	Yes	0	8	9
364	R:R:A531	R:R:F455	2.77	No	Yes	0	6	8
365	R:R:A531	R:R:F462	2.77	No	Yes	0	6	7
366	R:R:M131	R:R:Q99	2.72	No	No	0	5	9
367	R:R:P203	R:R:W206	2.7	No	Yes	0	4	4
368	R:R:D201	R:R:N202	2.69	No	No	0	5	5
369	R:R:A93	R:R:Y130	2.67	No	Yes	0	5	7
370	R:R:A327	R:R:Y323	2.67	No	Yes	0	9	8
371	R:R:F275	R:R:S278	2.64	Yes	No	0	5	8
372	R:R:E518	W:W:?1	2.64	No	Yes	0	7	0
373	R:R:F274	R:R:V270	2.62	No	No	0	9	8
374	R:R:R290	R:R:V294	2.62	No	No	0	9	8
375	R:R:H340	R:R:K344	2.62	Yes	No	0	7	6
376	R:R:F369	R:R:V373	2.62	No	No	0	7	7
377	R:R:F484	R:R:V488	2.62	Yes	No	0	6	6
378	R:R:D473	R:R:Q477	2.61	No	No	0	8	6
379	R:R:F523	R:R:I465	2.51	No	No	0	6	5
380	R:R:F275	R:R:L246	2.44	Yes	No	0	5	6
381	R:R:F268	R:R:L249	2.44	Yes	No	0	8	6
382	R:R:L92	R:R:R173	2.43	No	No	0	8	4
383	R:R:K356	R:R:Y337	2.39	No	Yes	0	8	7
384	R:R:D486	R:R:R485	2.38	No	Yes	0	4	5
385	R:R:G415	R:R:G416	2.11	No	No	0	8	5
386	R:R:F369	R:R:Y323	2.06	No	Yes	0	7	8
387	R:R:F474	R:R:Y397	2.06	Yes	No	0	6	3
388	R:R:G191	R:R:P116	2.03	No	No	0	5	9
389	R:R:G212	R:R:P116	2.03	No	No	0	7	9
390	R:R:C213	R:R:G214	1.96	No	No	0	9	8
391	R:R:C217	R:R:G299	1.96	No	No	0	9	4
392	R:R:A324	R:R:G277	1.95	No	No	0	7	6
393	R:R:A401	R:R:G402	1.95	No	No	0	6	5
394	R:R:A68	R:R:P69	1.87	No	No	0	5	4
395	R:R:A115	R:R:P116	1.87	No	No	0	6	9
396	R:R:A379	R:R:P306	1.87	No	No	0	6	5
397	R:R:A345	R:R:P352	1.87	No	Yes	0	7	7
398	R:R:A406	R:R:P407	1.87	No	No	0	5	9
399	R:R:G177	R:R:S143	1.86	No	No	0	2	8
400	R:R:G393	R:R:V392	1.84	No	No	0	9	9
401	R:R:G415	R:R:T336	1.82	No	No	0	8	7
402	R:R:A324	R:R:C273	1.81	No	No	0	7	9
403	R:R:P142	R:R:V129	1.77	No	No	0	8	7
404	R:R:G280	R:R:I279	1.76	No	No	0	7	5
405	R:R:G280	R:R:I317	1.76	No	No	0	7	7
406	R:R:G280	R:R:I320	1.76	No	No	0	7	5
407	R:R:G86	R:R:L73	1.71	No	No	0	6	7
408	R:R:C154	R:R:V121	1.71	No	No	0	9	7
409	R:R:C217	R:R:V294	1.71	No	No	11	9	8
410	R:R:C295	R:R:V294	1.71	No	No	11	9	8
411	R:R:G304	R:R:L303	1.71	No	No	0	5	3
412	R:R:G456	R:R:L419	1.71	No	No	0	7	7
413	R:R:A441	R:R:S438	1.71	No	No	0	8	8
414	R:R:G461	R:R:L464	1.71	No	No	0	5	4
415	R:R:A128	R:R:V182	1.7	No	No	0	8	4
416	R:R:A324	R:R:V276	1.7	No	No	0	7	5
417	R:R:C64	R:R:T179	1.69	No	No	7	7	4
418	R:R:C178	R:R:T179	1.69	No	No	7	6	4
419	R:R:D95	R:R:G94	1.68	Yes	No	0	5	5
420	R:R:A149	R:R:T150	1.68	No	Yes	0	4	7
421	R:R:A225	R:R:T223	1.68	No	No	0	4	5
422	R:R:A345	R:R:T348	1.68	No	No	0	7	7
423	R:R:L91	R:R:P69	1.64	No	No	0	5	4
424	R:R:L146	R:R:P124	1.64	Yes	No	0	6	5
425	R:R:L353	R:R:P263	1.64	No	No	0	8	9
426	R:R:L353	R:R:P352	1.64	No	Yes	0	8	7
427	R:R:D137	R:R:P69	1.61	No	No	0	4	4
428	R:R:S358	R:R:T357	1.6	No	No	0	6	6
429	R:R:G422	R:R:H340	1.59	No	Yes	0	8	7
430	R:R:P196	R:R:Q491	1.58	Yes	Yes	0	7	4
431	R:R:P352	R:R:Q351	1.58	Yes	No	0	7	7
432	R:R:E71	R:R:P72	1.57	No	No	0	7	4
433	R:R:E194	R:R:P196	1.57	Yes	Yes	0	6	7
434	R:R:A459	W:W:?1	1.57	No	Yes	0	7	0
435	R:R:I156	R:R:V157	1.54	No	No	0	5	6
436	R:R:I156	R:R:V210	1.54	No	No	0	5	5
437	R:R:I316	R:R:V315	1.54	No	Yes	0	5	7
438	R:R:K440	R:R:S438	1.53	No	No	0	6	8
439	R:R:C178	R:R:E140	1.52	No	No	0	6	5
440	R:R:G162	R:R:R161	1.5	No	No	0	3	5
441	R:R:L353	R:R:S342	1.5	No	No	0	8	8
442	R:R:L362	R:R:S366	1.5	No	No	0	5	7
443	R:R:N76	R:R:V82	1.48	No	No	0	4	4
444	R:R:D97	R:R:S98	1.47	No	No	0	3	6
445	R:R:D229	R:R:S232	1.47	No	No	0	6	4
446	R:R:L426	R:R:T448	1.47	No	No	0	9	8
447	R:R:I445	R:R:M449	1.46	No	Yes	0	9	9
448	R:R:I445	R:R:L437	1.43	No	No	0	9	6
449	R:R:Q491	R:R:V494	1.43	Yes	No	0	4	5
450	R:R:Q351	R:R:T349	1.42	No	No	0	7	6
451	R:R:E71	R:R:T90	1.41	No	No	0	7	5
452	R:R:K395	R:R:N396	1.4	No	No	0	3	7
453	R:R:D287	R:R:M286	1.39	No	No	0	5	4
454	R:R:C295	R:R:R291	1.39	No	No	0	9	5
455	R:R:A374	R:R:F403	1.39	No	No	0	5	8
456	R:R:L363	R:R:L367	1.38	No	No	0	4	5
457	R:R:E292	R:R:I293	1.37	No	No	0	5	8
458	R:R:E508	R:R:I509	1.37	No	No	0	4	4
459	R:R:R302	R:R:S313	1.32	Yes	No	0	6	7
460	R:R:D506	R:R:Q491	1.31	No	Yes	0	3	4
461	R:R:S514	R:R:Y472	1.27	No	No	0	7	7
462	R:R:H231	R:R:Q228	1.24	Yes	No	0	7	3
463	R:R:K356	R:R:Y359	1.19	No	No	0	8	7
464	R:R:E447	R:R:R451	1.16	No	No	0	6	9
465	R:R:R161	R:R:W109	1	No	Yes	0	5	7

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	R:R:D95	11.02	5	3	5
2	R:R:S96	4.9325	4	0	6
3	R:R:W109	4.63	4	3	7
4	R:R:R117	7.1125	4	5	5
5	R:R:I122	5.42	4	2	7
6	R:R:Y130	7.026	5	3	7
7	R:R:L141	5.4625	4	0	7
8	R:R:R144	7.33	4	8	6
9	R:R:L146	4.2875	4	0	6
10	R:R:T150	3.542	5	2	7
11	R:R:R151	6.6925	4	2	5
12	R:R:W163	11.436	5	2	8
13	R:R:F166	12.69	5	3	6
14	R:R:F187	8.05	4	0	6
15	R:R:E194	5.095	4	4	6
16	R:R:P196	3.345	4	0	7
17	R:R:W206	5.594	5	5	4
18	R:R:Y207	7.28	4	10	7
19	R:R:N219	6.055	4	0	7
20	R:R:F222	5.42333	6	1	6
21	R:R:H227	6.5975	4	0	7
22	R:R:H231	8.5625	4	0	7
23	R:R:Y262	7.282	5	0	9
24	R:R:F268	7.6375	4	0	8
25	R:R:Y269	7.8325	4	6	8
26	R:R:F275	3.48	4	0	5
27	R:R:W281	6.40333	6	1	7
28	R:R:F285	8.225	4	0	8
29	R:R:R296	7.46	4	0	6
30	R:R:R302	6.3325	4	14	6
31	R:R:E305	7.856	5	14	7
32	R:R:C314	5.8975	4	14	9
33	R:R:V315	4.3875	4	0	7
34	R:R:Y322	6.036	5	1	9
35	R:R:Y323	3.9125	4	0	8
36	R:R:W331	13.104	5	6	9
37	R:R:F332	6.95	4	1	9
38	R:R:Y337	7.33	4	0	7
39	R:R:W339	10.16	4	0	9
40	R:R:H340	5.0075	4	0	7
41	R:R:P352	3.666	5	0	7
42	R:R:F360	5.5675	4	0	9
43	R:R:H361	7.5125	4	6	9
44	R:R:R384	6.262	5	1	8
45	R:R:V386	6.835	4	1	5
46	R:R:F391	4.215	4	1	8
47	R:R:Y394	8.5175	4	1	5
48	R:R:M449	4.655	4	0	9
49	R:R:F455	7.555	4	1	8
50	R:R:F462	5.555	4	0	7
51	R:R:H470	8.97	5	1	7
52	R:R:F474	3.2075	4	0	6
53	R:R:W480	15.5575	4	0	9
54	R:R:F484	4.6275	4	0	6
55	R:R:R485	7.9475	4	10	5
56	R:R:Q491	3.0525	4	0	4
57	R:R:M525	7.2625	4	1	5
58	R:R:F526	6.44833	6	1	9
59	R:R:W535	9.36	4	0	9
60	W:W:?1	8.8575	16	1	0

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:L141	R:R:P175	11.7097	3.28	Yes	No	0	7	5
2	R:R:L141	R:R:V139	11.7097	2.98	Yes	No	0	7	7
3	R:R:L141	R:R:L92	25.9166	8.3	Yes	No	0	7	8
4	R:R:L92	R:R:R173	27.2024	2.43	No	No	0	8	4
5	R:R:F166	R:R:R173	29.7711	3.21	Yes	No	0	6	4
6	R:R:F166	R:R:L167	22.0765	17.05	Yes	No	0	6	7
7	R:R:L167	R:R:W163	22.9243	12.53	No	Yes	0	7	8
8	R:R:R151	R:R:W163	51.5511	6	Yes	Yes	2	5	8
9	R:R:R151	R:R:T150	41.5393	3.88	Yes	Yes	2	5	7
10	R:R:I122	R:R:T150	28.6378	4.56	Yes	Yes	2	7	7
11	R:R:I122	R:R:L112	27.082	2.85	Yes	No	0	7	8
12	R:R:L112	R:R:W119	26.2236	3.42	No	No	0	8	9
13	R:R:Q123	R:R:W119	23.6401	29.57	No	No	0	8	9
14	R:R:F187	R:R:Q123	22.777	5.86	Yes	No	0	6	8
15	R:R:F187	R:R:I185	19.315	7.54	Yes	No	0	6	4
16	R:R:I185	R:R:P84	14.0932	6.77	No	No	0	4	4
17	R:R:L83	R:R:P84	13.2195	3.28	No	No	0	7	4
18	R:R:L83	R:R:N76	12.3449	6.87	No	No	0	7	4
19	R:R:L73	R:R:N76	10.5928	4.12	No	No	0	7	4
20	R:R:F166	R:R:Y130	10.5894	8.25	Yes	Yes	3	6	7
21	R:R:W109	R:R:Y130	15.5982	6.75	Yes	Yes	3	7	7
22	R:R:V157	R:R:W109	22.3917	6.13	No	Yes	0	6	7
23	R:R:V157	R:R:W163	36.9964	23.29	No	Yes	0	6	8
24	R:R:I156	R:R:V157	59.2168	1.54	No	No	0	5	6
25	R:R:I156	R:R:V210	59.5661	1.54	No	No	0	5	5
26	R:R:V210	R:R:Y207	59.9158	5.05	No	Yes	0	5	7
27	R:R:I215	R:R:Y207	99.7001	10.88	No	Yes	0	5	7
28	R:R:F484	R:R:I215	100	5.02	Yes	No	0	6	5
29	R:R:F484	R:R:P220	32.7907	7.22	Yes	No	0	6	8
30	R:R:N219	R:R:P220	32.8785	6.52	Yes	No	0	7	8
31	R:R:N219	R:R:R384	61.1872	3.62	Yes	Yes	0	7	8
32	R:R:R384	R:R:Y394	96.2828	10.29	Yes	Yes	1	8	5
33	R:R:F391	R:R:Y394	30.425	4.13	Yes	Yes	1	8	5
34	R:R:F391	R:R:Y322	37.1005	5.16	Yes	Yes	1	8	9
35	R:R:F318	R:R:Y322	33.1069	8.25	No	Yes	0	9	9
36	R:R:F318	R:R:V381	31.4061	19.66	No	No	0	9	8
37	R:R:E305	R:R:V381	30.9614	7.13	Yes	No	0	7	8
38	R:R:E305	R:R:R302	23.0236	12.79	Yes	Yes	14	7	6
39	R:R:R296	R:R:R302	21.865	4.26	Yes	Yes	0	6	6
40	R:R:D298	R:R:R296	17.6464	3.57	No	Yes	0	7	6
41	R:R:D298	R:R:T200	12.8679	5.78	No	No	0	7	6
42	R:R:T200	R:R:W206	12.3847	7.28	No	Yes	0	6	4
43	R:R:E158	R:R:W163	36.9647	4.36	No	Yes	0	7	8
44	R:R:E158	R:R:R159	37.6959	3.49	No	No	0	7	5
45	R:R:R159	R:R:R485	38.061	6.4	No	Yes	0	5	5
46	R:R:R485	R:R:Y207	39.1174	5.14	Yes	Yes	10	5	7
47	R:R:F484	R:R:L221	67.8776	3.65	Yes	No	0	6	6
48	R:R:L221	R:R:N219	32.5974	9.61	No	Yes	0	6	7
49	R:R:F222	R:R:L221	35.5571	3.65	Yes	No	0	6	6
50	R:R:F222	R:R:R384	33.354	4.28	Yes	Yes	1	6	8
51	R:R:Y394	W:W:?1	65.3526	7.01	Yes	Yes	1	5	0
52	R:R:F332	W:W:?1	48.8083	3.64	Yes	Yes	1	9	0
53	R:R:F332	R:R:F455	41.3397	6.43	Yes	Yes	1	9	8
54	R:R:F455	R:R:W535	41.1109	16.04	Yes	Yes	0	8	9
55	R:R:W339	R:R:W535	35.736	8.43	Yes	Yes	0	9	9
56	R:R:L335	R:R:W339	29.9371	21.64	No	Yes	0	8	9
57	R:R:I266	R:R:L335	29.4995	5.71	No	No	0	8	8
58	R:R:I266	R:R:W331	14.1061	5.87	No	Yes	0	8	9
59	R:R:I266	R:R:Y262	15.0436	4.84	No	Yes	0	8	9

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:I234	R:R:W281	4.7	1	No	Yes	7	7	2	1
R:R:F526	R:R:I234	3.77	1	Yes	No	9	7	2	2
R:R:V321	R:R:W281	6.13	0	No	Yes	8	7	2	1
R:R:I389	R:R:W281	7.05	0	No	Yes	9	7	2	1
R:R:M525	R:R:W281	6.98	1	Yes	Yes	5	7	1	1
R:R:F526	R:R:W281	9.02	1	Yes	Yes	9	7	2	1
R:R:W281	W:W:?1	4.54	1	Yes	Yes	7	0	1	0
R:R:F391	R:R:V321	3.93	1	Yes	No	8	8	1	2
R:R:F391	R:R:Y322	5.16	1	Yes	Yes	8	9	1	2
R:R:L325	R:R:M525	4.24	1	No	Yes	5	5	1	1
R:R:L325	W:W:?1	12.42	1	No	Yes	5	0	1	0
R:R:I408	R:R:V329	4.61	1	No	No	7	6	1	1
R:R:V329	R:R:V411	4.81	1	No	No	6	5	1	2
R:R:V329	W:W:?1	5.94	1	No	Yes	6	0	1	0
R:R:F332	R:R:T336	7.78	1	Yes	No	9	7	1	2
R:R:F332	R:R:F455	6.43	1	Yes	Yes	9	8	1	2
R:R:F332	R:R:M532	9.95	1	Yes	No	9	8	1	2
R:R:F332	W:W:?1	3.64	1	Yes	Yes	9	0	1	0
R:R:D382	R:R:Y394	12.64	0	No	Yes	9	5	2	1
R:R:R384	R:R:Y394	10.29	1	Yes	Yes	8	5	2	1
R:R:F391	R:R:Y394	4.13	1	Yes	Yes	8	5	1	1
R:R:F391	W:W:?1	3.64	1	Yes	Yes	8	0	1	0
R:R:Y394	W:W:?1	7.01	1	Yes	Yes	5	0	1	0
R:R:V404	W:W:?1	8.91	0	No	Yes	7	0	1	0
R:R:H470	R:R:L405	9	1	Yes	No	7	8	1	2
R:R:I408	W:W:?1	11.39	1	No	Yes	7	0	1	0
R:R:L412	R:R:V463	7.45	0	No	No	7	7	2	1
R:R:F455	R:R:M532	4.98	1	Yes	No	8	8	2	2
R:R:F462	R:R:T528	5.19	0	Yes	No	7	7	2	1
R:R:V463	W:W:?1	4.46	0	No	Yes	7	0	1	0
R:R:H470	R:R:T466	6.85	1	Yes	No	7	8	1	1
R:R:T466	W:W:?1	14.7	1	No	Yes	8	0	1	0
R:R:C469	R:R:N521	11.02	0	No	No	7	8	2	1
R:R:H470	R:R:N521	6.38	1	Yes	No	7	8	1	1
R:R:H470	W:W:?1	19.23	1	Yes	Yes	7	0	1	0
R:R:N521	W:W:?1	5.48	1	No	Yes	8	0	1	0
R:R:F526	R:R:M525	3.73	1	Yes	Yes	9	5	2	1
R:R:M525	W:W:?1	14.1	1	Yes	Yes	5	0	1	0
R:R:T528	W:W:?1	22.05	0	No	Yes	7	0	1	0
R:R:F474	R:R:H470	3.39	0	Yes	Yes	6	7	2	1
R:R:E518	W:W:?1	2.64	0	No	Yes	7	0	1	0
R:R:A459	W:W:?1	1.57	0	No	Yes	7	0	1	0

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	6XBJ_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	3.49
Number of Linked Nodes	427
Number of Links	465
Number of Hubs	60
Number of Links mediated by Hubs	224
Number of Communities	15
Number of Nodes involved in Communities	72
Number of Links involved in Communities	88

Path Summary
Number Of Nodes in MetaPath	60
Number Of Links MetaPath	59
Number of Shortest Paths	266562
Length Of Smallest Path	3
Average Path Length	22.4777
Length of Longest Path	51
Minimum Path Strength	1.25
Average Path Strength	6.96038
Maximum Path Strength	25.49
Minimum Path Correlation	0.7
Average Path Correlation	0.961039
Maximum Path Correlation	1
Minimum % Of Corr. Nodes	2.77778
Average % Of Corr. Nodes	56.0319
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	51.2266
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process
Gene Ontology	Cellular Component
SCOP2	Domain Identifier	• Transducin (heterotrimeric G protein), gamma chain • Ras-like P-loop GTPases • G protein-coupled receptor-like
SCOP2	Family Identifier	• Transducin (heterotrimeric G protein), gamma chain • Ras-like P-loop GTPases • G protein-coupled receptor-like
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	CLR
PDB Residues	W:W:?1
Environment Details	Open EMBL-EBI Page
Code	CLR
Name	Cholesterol
Synonyms	Cholesterin Cholesterol Cholest-5-en-3beta-ol (3β,14β,17α)-cholest-5-en-3-ol
Identifier
Formula	C27 H46 O
Molecular Weight	386.654
SMILES
PubChem	5997
Formal Charge	0
Total Atoms	74
Total Chiral Atoms	8
Total Bonds	77
Total Aromatic Bonds	0


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	Q99835
Sequence	>6XBJ_nogp_Chain_R H C G R A A P C E P L R Y N V C L G S V L P Y G A T S T L L A G D S D S Q E E A H G K L V L W S G L R N A P R C W A V I Q P L L C A V Y M P K C E N D R V E L P S R T L C Q A T R G P C A I V E R E R G W P D F L R C T P D R F P E G C T N E V Q N I K F N S S G Q C E V P L V R T D N P K S W Y E D V E G C G I Q C Q N P L F T E A E H Q D M H S Y I A A F G A V T G L C T L F T L A T F V A D W R N S N R Y P A V I L F Y V N A C F F V G S I G W L A Q F M D G A R R E I V C R A D G T M R L G E P T S N E T L S C V I I F V I V Y Y A L M A G V V W F V V L T Y A W H T S F K A L G T T Y Q P L S G K T S Y F H L L T W S L P F V L T V A I L A V A Q V D G R S V S G I C F V G Y K N Y R Y R A G F V L A P I G L V L I V G G Y F L I R G V M T L F S I K S N H P G L L S E K A A S K I N E T M L R L G I F G F L A F G F V L I T F S C H F Y D F F N Q A E W E R S F R D Y V L C Q A N V D C E I K N R P S L L V E K I N L F A M F G T G I A M S T W V W T Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	4JKV	F	Protein	Frizzled	SMO	Homo sapiens	Taladegib	-	-	2.45	2013-04-24	doi.org/10.1038/nature12167
	4N4W	F	Protein	Frizzled	SMO	Homo sapiens	-	SANT-1	-	2.8	2014-01-22	doi.org/10.1038/ncomms5355
	4O9R	F	Protein	Frizzled	SMO	Homo sapiens	Cyclopamine	-	-	3.2	2014-03-05	doi.org/10.1038/ncomms4309
	4QIM	F	Protein	Frizzled	SMO	Homo sapiens	ANTA XV	-	-	2.61	2014-07-23	doi.org/10.1038/ncomms5355
	4QIN	F	Protein	Frizzled	SMO	Homo sapiens	SAG1.5	-	-	2.6	2014-07-23	doi.org/10.1038/ncomms5355
	5L7D	F	Protein	Frizzled	SMO	Homo sapiens	-	Cholesterol	-	3.2	2016-07-20	doi.org/10.1038/nature18934
	5L7I	F	Protein	Frizzled	SMO	Homo sapiens	Vismodegib	-	-	3.3	2016-07-20	doi.org/10.1038/nature18934
	5V56	F	Protein	Frizzled	SMO	Homo sapiens	TC114	-	-	2.9	2017-05-24	doi.org/10.1038/ncomms15383
	5V57	F	Protein	Frizzled	SMO	Homo sapiens	TC114	-	-	3	2017-05-24	doi.org/10.1038/ncomms15383
	6D32	F	Protein	Frizzled	SMO	Xenopus laevis	Cyclopamine	Cyclopamine	-	3.75	2018-05-23	doi.org/10.1016/j.cell.2018.04.029
	6D35	F	Protein	Frizzled	SMO	Xenopus laevis	-	Cholesterol	-	3.9	2018-05-23	doi.org/10.1016/j.cell.2018.04.029
	6OT0	F	Protein	Frizzled	SMO	Homo sapiens	-	25(S)-Epoxycholesterol	Gi1/β1/γ2	3.84	2019-06-12	doi.org/10.1038/s41586-019-1286-0
	6OT0 (No Gprot)	F	Protein	Frizzled	SMO	Homo sapiens	-	25(S)-Epoxycholesterol		3.84	2019-06-12	doi.org/10.1038/s41586-019-1286-0
	6O3C	F	Protein	Frizzled	SMO	Mus musculus	SAG21k	Cholesterol	-	2.8	2019-07-03	doi.org/10.1038/s41586-019-1355-4
	6XBJ	F	Protein	Frizzled	SMO	Homo sapiens	-	Cholesterol	Gi1/β1/γ2	3.88	2020-09-30	doi.org/10.1038/s41589-020-0646-2
	6XBJ (No Gprot)	F	Protein	Frizzled	SMO	Homo sapiens	-	Cholesterol		3.88	2020-09-30	doi.org/10.1038/s41589-020-0646-2
	6XBK	F	Protein	Frizzled	SMO	Homo sapiens	-	Cholesterol	Gi1/β1/γ2	3.24	2020-09-30	doi.org/10.1038/s41589-020-0646-2
	6XBK (No Gprot)	F	Protein	Frizzled	SMO	Homo sapiens	-	Cholesterol		3.24	2020-09-30	doi.org/10.1038/s41589-020-0646-2
	6XBL	F	Protein	Frizzled	SMO	Homo sapiens	SAG	Cholesterol	Gi1/β1/γ2	3.96	2020-09-30	doi.org/10.1038/s41589-020-0646-2
	6XBL (No Gprot)	F	Protein	Frizzled	SMO	Homo sapiens	SAG	Cholesterol		3.96	2020-09-30	doi.org/10.1038/s41589-020-0646-2
	6XBM	F	Protein	Frizzled	SMO	Homo sapiens	-	25(S)-Epoxycholesterol	Gi1/β1/γ2	3.14	2020-09-30	doi.org/10.1038/s41589-020-0646-2
	6XBM (No Gprot)	F	Protein	Frizzled	SMO	Homo sapiens	-	25(S)-Epoxycholesterol		3.14	2020-09-30	doi.org/10.1038/s41589-020-0646-2
	7ZI0	F	Protein	Frizzled	SMO	Homo sapiens	SAG	Cholesterol	-	3	2022-06-15	doi.org/10.1126/sciadv.abm5563
	8CXO	F	Protein	Frizzled	SMO	Mus musculus	-	-	-	3.7	2022-08-03	doi.org/10.1038/s41467-022-32125-2

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