psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:H63	R:R:P175	4.58	No	No	0	3	5
2	R:R:C64	R:R:P175	5.65	No	No	0	7	5
3	R:R:C178	R:R:C64	7.28	No	No	0	6	7
4	R:R:G65	R:R:R138	6	No	No	0	4	4
5	R:R:L91	R:R:R66	7.29	No	No	0	5	6
6	R:R:L141	R:R:R66	10.93	No	No	0	7	6
7	R:R:R173	R:R:R66	4.26	No	No	0	4	6
8	R:R:A68	R:R:V139	3.39	No	No	0	5	7
9	R:R:C70	R:R:S89	3.44	No	No	0	9	8
10	R:R:C134	R:R:C70	5.46	No	No	0	9	9
11	R:R:E71	R:R:R74	3.49	No	No	5	7	4
12	R:R:E71	R:R:Q99	8.92	No	No	5	7	9
13	R:R:L73	R:R:N76	4.12	No	No	0	7	4
14	R:R:G86	R:R:L73	3.42	No	No	0	6	7
15	R:R:Q99	R:R:R74	15.19	No	No	5	9	4
16	R:R:H103	R:R:Y75	11.98	No	No	0	5	3
17	R:R:N76	R:R:V82	4.43	No	No	0	4	4
18	R:R:L83	R:R:N76	4.12	No	No	0	7	4
19	R:R:C78	R:R:S81	3.44	Yes	No	4	9	5
20	R:R:C127	R:R:C78	7.28	No	Yes	0	9	9
21	R:R:C78	R:R:I185	4.91	Yes	Yes	4	9	4
22	R:R:C78	R:R:F187	4.19	Yes	Yes	4	9	6
23	R:R:L106	R:R:L79	4.15	No	No	0	8	5
24	R:R:L79	R:R:R113	4.86	No	No	0	5	5
25	R:R:F187	R:R:S81	9.25	Yes	No	4	6	5
26	R:R:L83	R:R:Y85	14.07	No	Yes	0	7	9
27	R:R:P84	R:R:Y85	4.17	No	Yes	0	4	9
28	R:R:N184	R:R:P84	6.52	No	No	4	3	4
29	R:R:I185	R:R:P84	5.08	Yes	No	4	4	4
30	R:R:M131	R:R:Y85	3.59	Yes	Yes	0	5	9
31	R:R:K133	R:R:Y85	7.17	Yes	Yes	0	6	9
32	R:R:A87	R:R:C134	3.61	No	No	0	4	9
33	R:R:Q99	R:R:T88	12.76	No	No	0	9	9
34	R:R:M131	R:R:T88	4.52	Yes	No	0	5	9
35	R:R:L92	R:R:V129	4.47	No	No	0	8	7
36	R:R:L141	R:R:L92	4.15	No	No	0	7	8
37	R:R:L92	R:R:R173	3.64	No	No	0	8	4
38	R:R:A93	R:R:S96	3.42	No	No	0	5	6
39	R:R:D95	R:R:K105	4.15	Yes	Yes	2	5	4
40	R:R:D95	R:R:P164	6.44	Yes	No	2	5	9
41	R:R:D95	R:R:F166	3.58	Yes	Yes	2	5	6
42	R:R:H103	R:R:V107	6.92	No	No	0	5	4
43	R:R:K105	R:R:L108	7.05	Yes	No	2	4	5
44	R:R:K105	R:R:W109	8.12	Yes	Yes	2	4	7
45	R:R:K105	R:R:Y130	15.53	Yes	Yes	2	4	7
46	R:R:L108	R:R:W109	10.25	No	Yes	2	5	7
47	R:R:L126	R:R:W109	3.42	No	Yes	0	9	7
48	R:R:W109	R:R:Y130	6.75	Yes	Yes	2	7	7
49	R:R:V157	R:R:W109	6.13	No	Yes	0	6	7
50	R:R:R113	R:R:S110	5.27	No	No	0	5	5
51	R:R:G111	R:R:I496	3.53	No	No	0	5	4
52	R:R:L112	R:R:W119	3.42	No	Yes	0	8	9
53	R:R:R113	R:R:W119	13.99	No	Yes	0	5	9
54	R:R:L197	R:R:N114	8.24	No	No	0	9	5
55	R:R:A115	R:R:E211	6.03	No	Yes	0	6	5
56	R:R:G191	R:R:P116	4.06	No	No	0	5	9
57	R:R:R117	R:R:W206	20.99	No	Yes	0	5	4
58	R:R:E211	R:R:R117	9.3	Yes	No	0	5	5
59	R:R:G212	R:R:R117	6	No	No	0	7	5
60	R:R:C118	R:R:C154	7.28	No	No	0	9	9
61	R:R:C118	R:R:E211	7.6	No	Yes	0	9	5
62	R:R:Q123	R:R:W119	19.71	No	Yes	0	8	9
63	R:R:Q192	R:R:W119	4.38	No	Yes	0	4	9
64	R:R:A120	R:R:S190	3.42	No	No	0	4	6
65	R:R:T150	R:R:V121	4.76	Yes	No	0	7	7
66	R:R:I122	R:R:L125	5.71	No	Yes	0	7	7
67	R:R:I122	R:R:L126	9.99	No	No	0	7	9
68	R:R:I122	R:R:T150	7.6	No	Yes	0	7	7
69	R:R:F187	R:R:Q123	21.08	Yes	No	0	6	8
70	R:R:F187	R:R:P124	10.11	Yes	No	0	6	5
71	R:R:L125	R:R:L146	9.69	Yes	No	0	7	6
72	R:R:L125	R:R:R151	3.64	Yes	Yes	0	7	5
73	R:R:L125	R:R:L167	4.15	Yes	No	0	7	7
74	R:R:V129	R:R:Y130	3.79	No	Yes	2	7	7
75	R:R:F166	R:R:V129	3.93	Yes	No	2	6	7
76	R:R:M131	R:R:Y130	3.59	Yes	Yes	0	5	7
77	R:R:F166	R:R:Y130	9.28	Yes	Yes	2	6	7
78	R:R:E140	R:R:K133	5.4	No	Yes	6	5	6
79	R:R:E181	R:R:K133	5.4	No	Yes	6	5	6
80	R:R:E135	R:R:R138	3.49	No	No	0	6	4
81	R:R:E140	R:R:E181	16.49	No	No	6	5	5
82	R:R:L141	R:R:P175	8.21	No	No	0	7	5
83	R:R:F174	R:R:P142	14.45	No	No	0	8	8
84	R:R:S143	R:R:T145	4.8	No	No	0	8	6
85	R:R:Q148	R:R:R144	7.01	No	No	0	5	6
86	R:R:P171	R:R:R144	4.32	No	No	0	3	6
87	R:R:E176	R:R:R144	10.47	No	No	0	4	6
88	R:R:L146	R:R:N180	6.87	No	No	0	6	5
89	R:R:C147	R:R:R151	8.36	No	Yes	0	9	5
90	R:R:C147	R:R:C169	7.28	No	No	0	9	9
91	R:R:R151	R:R:T150	9.06	Yes	Yes	0	5	7
92	R:R:C154	R:R:T150	5.07	No	Yes	0	9	7
93	R:R:R151	R:R:W163	12	Yes	Yes	7	5	8
94	R:R:R151	R:R:R168	4.26	Yes	No	7	5	4
95	R:R:G152	R:R:P153	4.06	No	No	0	4	6
96	R:R:C154	R:R:P153	3.77	No	No	0	9	6
97	R:R:E211	R:R:I156	8.2	Yes	No	0	5	5
98	R:R:V157	R:R:W163	17.16	No	Yes	0	6	8
99	R:R:E158	R:R:W163	6.54	No	Yes	0	7	8
100	R:R:D209	R:R:R159	4.76	No	No	0	4	5
101	R:R:R159	R:R:R485	8.53	No	No	0	5	5
102	R:R:E160	R:R:R161	5.82	No	No	0	4	5
103	R:R:E160	R:R:L489	7.95	No	No	0	4	4
104	R:R:L167	R:R:W163	4.56	No	Yes	0	7	8
105	R:R:R168	R:R:W163	19.99	No	Yes	7	4	8
106	R:R:F166	R:R:P164	7.22	Yes	No	2	6	9
107	R:R:F166	R:R:L167	15.83	Yes	No	0	6	7
108	R:R:C169	R:R:F174	6.98	No	No	0	9	8
109	R:R:P171	R:R:T170	6.99	No	No	0	3	6
110	R:R:D172	R:R:T170	7.23	No	No	0	4	6
111	R:R:D172	R:R:R173	3.57	No	No	0	4	4
112	R:R:N180	R:R:V182	7.39	No	No	0	5	4
113	R:R:I185	R:R:V182	4.61	Yes	No	0	4	4
114	R:R:I185	R:R:N184	5.66	Yes	No	4	4	3
115	R:R:F187	R:R:I185	6.28	Yes	Yes	4	6	4
116	R:R:C193	R:R:R199	4.18	No	No	0	9	4
117	R:R:C193	R:R:C213	7.28	No	No	0	9	9
118	R:R:P196	R:R:V195	3.53	No	No	0	7	4
119	R:R:C213	R:R:L197	11.11	No	No	0	9	9
120	R:R:T200	R:R:W206	4.85	No	Yes	0	6	4
121	R:R:D298	R:R:T200	10.12	Yes	No	0	7	6
122	R:R:N202	R:R:P203	4.89	Yes	No	0	5	4
123	R:R:K204	R:R:N202	5.6	No	Yes	1	3	5
124	R:R:N202	R:R:S205	4.47	Yes	No	1	5	7
125	R:R:N202	R:R:R296	3.62	Yes	Yes	1	5	6
126	R:R:P203	R:R:W206	6.76	No	Yes	0	4	4
127	R:R:K204	R:R:S205	9.18	No	No	1	3	7
128	R:R:K204	R:R:T307	10.51	No	No	0	3	6
129	R:R:R296	R:R:S205	7.91	Yes	No	1	6	7
130	R:R:D209	R:R:Y207	22.99	No	Yes	1	4	7
131	R:R:V210	R:R:Y207	5.05	No	Yes	1	5	7
132	R:R:F484	R:R:Y207	6.19	Yes	Yes	1	6	7
133	R:R:V488	R:R:Y207	7.57	No	Yes	1	6	7
134	R:R:D209	R:R:V210	7.3	No	No	1	4	5
135	R:R:E211	R:R:V210	4.28	Yes	No	0	5	5
136	R:R:I215	R:R:Q216	5.49	No	No	0	5	7
137	R:R:I215	R:R:P220	5.08	No	No	0	5	8
138	R:R:I215	R:R:M301	7.29	No	No	0	5	4
139	R:R:C217	R:R:C295	7.28	No	No	0	9	9
140	R:R:E224	R:R:Q218	7.65	No	No	0	4	5
141	R:R:Q218	R:R:R291	3.5	No	No	0	5	5
142	R:R:N219	R:R:P220	6.52	Yes	No	0	7	8
143	R:R:L221	R:R:N219	5.49	No	Yes	0	6	7
144	R:R:F222	R:R:N219	8.46	Yes	Yes	0	6	7
145	R:R:N219	R:R:V386	4.43	Yes	No	0	7	5
146	L:L:?1	R:R:N219	12.94	Yes	Yes	0	0	7
147	R:R:F484	R:R:P220	4.33	Yes	No	0	6	8
148	R:R:L221	R:R:P513	6.57	No	No	0	6	8
149	R:R:E226	R:R:F222	9.33	No	Yes	0	8	6
150	R:R:F222	R:R:H227	4.53	Yes	No	0	6	7
151	R:R:F222	R:R:R512	7.48	Yes	No	0	6	6
152	R:R:F222	R:R:P513	8.67	Yes	No	0	6	8
153	R:R:F222	R:R:L515	3.65	Yes	No	0	6	5
154	R:R:E226	R:R:T223	8.47	No	No	0	8	5
155	R:R:E224	R:R:H227	14.77	No	No	0	4	7
156	R:R:D229	R:R:M230	4.16	No	No	8	6	7
157	R:R:D229	R:R:K519	4.15	No	Yes	8	6	7
158	R:R:L515	R:R:M230	12.72	No	No	0	5	7
159	R:R:K519	R:R:M230	8.64	Yes	No	8	7	7
160	R:R:H231	R:R:Q284	6.18	No	No	9	7	9
161	R:R:F285	R:R:H231	7.92	Yes	No	9	8	7
162	R:R:F237	R:R:Y233	15.47	No	No	0	4	6
163	R:R:K519	R:R:Y233	21.5	Yes	No	0	7	6
164	R:R:L522	R:R:Y233	3.52	No	No	0	7	6
165	R:R:I234	R:R:W281	7.05	No	Yes	0	7	7
166	R:R:F285	R:R:I234	3.77	Yes	No	0	8	7
167	R:R:A235	R:R:F285	4.16	No	Yes	0	5	8
168	R:R:F237	R:R:F523	5.36	No	No	0	4	6
169	R:R:F237	R:R:F526	11.79	No	No	0	4	9
170	R:R:G238	R:R:L282	3.42	No	No	0	7	7
171	R:R:F526	R:R:G238	4.52	No	No	0	9	7
172	R:R:F526	R:R:T241	5.19	No	No	0	9	7
173	R:R:G242	R:R:S278	3.71	No	No	0	4	8
174	R:R:C244	R:R:I530	4.91	No	No	0	6	7
175	R:R:C244	R:R:S533	3.44	No	No	0	6	9
176	R:R:F275	R:R:T245	3.89	No	No	0	5	8
177	R:R:F247	R:R:T251	5.19	No	No	10	8	9
178	R:R:F247	R:R:V536	5.24	No	Yes	10	8	8
179	R:R:N271	R:R:T248	11.7	No	No	0	9	8
180	R:R:S533	R:R:T248	4.8	No	No	0	9	8
181	R:R:T248	R:R:V536	7.93	No	Yes	0	8	8
182	R:R:F268	R:R:L249	3.65	No	No	0	8	6
183	R:R:F275	R:R:L249	4.87	No	No	0	5	6
184	R:R:T251	R:R:V536	4.76	No	Yes	10	9	8
185	R:R:F252	R:R:F268	8.57	No	No	0	9	8
186	R:R:F252	R:R:V536	3.93	No	Yes	0	9	8
187	R:R:N260	R:R:W256	6.78	No	No	0	7	7
188	R:R:R261	R:R:S259	10.54	No	No	0	7	8
189	R:R:A264	R:R:R261	5.53	No	No	0	9	7
190	R:R:I266	R:R:Y262	4.84	Yes	Yes	3	8	9
191	R:R:T357	R:R:Y262	9.99	No	Yes	3	6	9
192	R:R:F360	R:R:Y262	8.25	Yes	Yes	3	9	9
193	R:R:H361	R:R:Y262	5.44	Yes	Yes	3	9	9
194	R:R:V265	R:R:Y269	5.05	No	Yes	0	8	8
195	R:R:I266	R:R:W331	7.05	Yes	Yes	3	8	9
196	R:R:I266	R:R:L335	5.71	Yes	No	0	8	8
197	R:R:F360	R:R:I266	6.28	Yes	Yes	3	9	8
198	R:R:L267	R:R:W535	14.81	No	Yes	0	8	9
199	R:R:F268	R:R:Y269	5.16	No	Yes	0	8	8
200	R:R:W331	R:R:Y269	14.47	Yes	Yes	3	9	8
201	R:R:H361	R:R:Y269	5.44	Yes	Yes	3	9	8
202	R:R:M532	R:R:V270	4.56	No	No	0	8	8
203	R:R:C273	R:R:G328	3.92	No	No	0	9	8
204	R:R:F274	R:R:G529	4.52	No	No	0	9	9
205	R:R:F275	R:R:I279	6.28	No	No	0	5	5
206	R:R:G280	R:R:I320	3.53	No	No	0	7	5
207	R:R:V321	R:R:W281	4.9	No	Yes	0	8	7
208	R:R:I389	R:R:W281	5.87	No	Yes	0	9	7
209	R:R:L522	R:R:W281	4.56	No	Yes	0	7	7
210	R:R:M525	R:R:W281	9.31	No	Yes	1	5	7
211	R:R:W281	W:W:?1	4.54	Yes	Yes	1	7	0
212	R:R:F285	R:R:Q284	8.2	Yes	No	9	8	9
213	R:R:G388	R:R:Q284	4.93	No	No	0	9	9
214	R:R:D287	R:R:G288	3.35	No	No	0	5	6
215	R:R:R290	R:R:R291	19.19	No	No	0	9	5
216	R:R:D298	R:R:R296	8.34	Yes	Yes	0	7	6
217	R:R:R296	R:R:R302	9.6	Yes	Yes	1	6	6
218	R:R:E310	R:R:R296	4.65	No	Yes	0	8	6
219	R:R:A297	R:R:E310	4.53	No	No	0	5	8
220	R:R:D298	R:R:T300	10.12	Yes	No	0	7	7
221	R:R:L303	R:R:M301	4.24	No	No	0	3	4
222	L:L:?1	R:R:M301	5.71	Yes	No	0	0	4
223	R:R:E305	R:R:R302	13.96	Yes	Yes	1	7	6
224	R:R:C314	R:R:R302	4.18	Yes	Yes	1	9	6
225	R:R:E305	R:R:P306	7.86	Yes	Yes	0	7	5
226	R:R:C314	R:R:E305	6.08	Yes	Yes	1	9	7
227	R:R:E305	R:R:V381	4.28	Yes	No	1	7	8
228	R:R:P306	R:R:V315	10.6	Yes	No	0	5	7
229	R:R:N309	R:R:T307	5.85	No	No	0	6	6
230	R:R:L312	R:R:V315	4.47	No	No	0	7	7
231	R:R:C314	R:R:C390	7.28	Yes	No	0	9	9
232	R:R:I317	R:R:I389	4.42	No	No	0	7	9
233	R:R:F318	R:R:Y322	7.22	Yes	Yes	1	9	9
234	R:R:F318	R:R:V381	15.73	Yes	No	1	9	8
235	R:R:F318	R:R:F391	6.43	Yes	Yes	1	9	8
236	R:R:F318	R:R:V392	5.24	Yes	No	1	9	9
237	R:R:T372	R:R:V319	6.35	No	No	0	9	7
238	R:R:M326	R:R:Y322	5.99	No	Yes	0	8	9
239	R:R:L371	R:R:Y322	5.86	No	Yes	0	8	9
240	R:R:F391	R:R:Y322	4.13	Yes	Yes	1	8	9
241	R:R:W365	R:R:Y323	7.72	No	Yes	0	9	8
242	R:R:P368	R:R:Y323	6.95	No	Yes	0	9	8
243	R:R:F369	R:R:Y323	4.13	No	Yes	0	7	8
244	R:R:L325	R:R:M525	4.24	No	No	0	5	5
245	R:R:M326	R:R:P368	3.35	No	No	0	8	9
246	R:R:M326	R:R:P407	6.71	No	No	0	8	9
247	R:R:V329	R:R:V411	4.81	No	No	0	6	5
248	R:R:T364	R:R:V330	4.76	No	No	0	9	6
249	R:R:H361	R:R:W331	6.35	Yes	Yes	3	9	9
250	R:R:T364	R:R:W331	20.62	No	Yes	0	9	9
251	R:R:W331	R:R:W365	11.25	Yes	No	3	9	9
252	R:R:F332	R:R:T336	5.19	Yes	No	0	9	7
253	R:R:F332	R:R:F455	6.43	Yes	No	11	9	8
254	R:R:F332	R:R:M532	7.46	Yes	No	11	9	8
255	R:R:F360	R:R:V334	9.18	Yes	No	0	9	7
256	R:R:L335	R:R:W339	21.64	No	Yes	0	8	9
257	R:R:F418	R:R:Y337	11.35	No	No	0	8	7
258	R:R:W339	R:R:W535	10.31	Yes	Yes	0	9	9
259	R:R:H340	R:R:K344	5.24	No	No	0	7	6
260	R:R:H340	R:R:R421	4.51	No	No	0	7	7
261	R:R:G422	R:R:H340	4.77	No	No	0	8	7
262	R:R:P352	R:R:T341	10.49	No	No	0	7	6
263	R:R:F343	R:R:L426	15.83	No	No	0	9	9
264	R:R:F360	R:R:T357	3.89	Yes	No	3	9	6
265	R:R:H361	R:R:W365	10.58	Yes	No	3	9	9
266	R:R:F403	R:R:I375	6.28	No	No	0	8	7
267	R:R:K395	R:R:Q380	4.07	Yes	No	1	3	7
268	R:R:N396	R:R:Q380	11.88	No	No	1	7	7
269	R:R:V381	R:R:V392	4.81	No	No	1	8	9
270	R:R:D382	R:R:G383	3.35	No	No	0	9	8
271	R:R:D382	R:R:Y394	6.9	No	Yes	0	9	5
272	R:R:C390	R:R:G383	3.92	No	No	0	9	8
273	R:R:D384	R:R:V386	5.84	No	No	0	8	5
274	R:R:D384	R:R:S387	11.78	No	No	0	8	8
275	R:R:D384	R:R:Y394	16.09	No	Yes	0	8	5
276	R:R:I389	R:R:S387	4.64	No	No	0	9	8
277	R:R:F391	R:R:V392	3.93	Yes	No	1	8	9
278	R:R:F391	R:R:Y394	8.25	Yes	Yes	1	8	5
279	R:R:F391	W:W:?1	14.57	Yes	Yes	1	8	0
280	L:L:?1	R:R:Y394	8.68	Yes	Yes	1	0	5
281	R:R:Y394	W:W:?1	7.01	Yes	Yes	1	5	0
282	R:R:K395	R:R:N396	6.99	Yes	No	1	3	7
283	R:R:E481	R:R:K395	4.05	No	Yes	1	5	3
284	L:L:?1	R:R:K395	10.44	Yes	Yes	1	0	3
285	R:R:N396	R:R:Y399	4.65	No	No	0	7	5
286	R:R:R398	R:R:Y397	5.14	No	No	0	1	3
287	R:R:Q477	R:R:Y397	6.76	No	No	0	6	3
288	R:R:H470	R:R:R400	3.39	Yes	Yes	1	7	9
289	R:R:D473	R:R:R400	10.72	No	Yes	0	8	9
290	R:R:F474	R:R:R400	7.48	Yes	Yes	1	6	9
291	R:R:A401	R:R:F474	8.32	No	Yes	0	6	6
292	R:R:H470	R:R:V404	12.45	Yes	No	1	7	7
293	R:R:V404	W:W:?1	5.94	No	Yes	1	7	0
294	R:R:F467	R:R:L405	9.74	No	No	0	7	8
295	R:R:I408	R:R:V463	4.61	No	No	0	7	7
296	R:R:I408	W:W:?1	9.96	No	Yes	0	7	0
297	R:R:L412	R:R:V463	8.94	No	No	0	7	7
298	R:R:F418	R:R:Y417	5.16	No	No	0	8	5
299	R:R:R421	R:R:Y417	9.26	No	No	0	7	5
300	R:R:L419	R:R:L452	5.54	No	No	0	7	8
301	R:R:N432	R:R:S428	5.96	No	No	0	6	5
302	R:R:H433	R:R:P434	9.15	Yes	No	0	8	7
303	R:R:H433	R:R:L437	3.86	Yes	No	0	8	6
304	R:R:E439	R:R:S438	4.31	No	No	0	5	8
305	R:R:E439	R:R:K440	4.05	No	No	0	5	6
306	R:R:K440	R:R:K444	5.75	No	No	0	6	9
307	R:R:R451	R:R:W535	11	No	Yes	0	9	9
308	R:R:F455	R:R:M532	4.98	No	No	11	8	8
309	R:R:F455	R:R:W535	17.04	No	Yes	0	8	9
310	R:R:F462	R:R:G527	4.52	Yes	No	0	7	5
311	R:R:F462	R:R:T528	7.78	Yes	No	0	7	7
312	R:R:H470	R:R:T466	6.85	Yes	No	0	7	8
313	R:R:C469	R:R:V517	5.12	No	No	0	7	6
314	R:R:C469	R:R:N521	11.02	No	No	0	7	8
315	R:R:F474	R:R:H470	7.92	Yes	Yes	1	6	7
316	R:R:H470	W:W:?1	10.26	Yes	Yes	1	7	0
317	R:R:N476	R:R:Y472	8.14	No	No	0	6	7
318	R:R:V517	R:R:Y472	7.57	No	No	0	6	7
319	L:L:?1	R:R:D473	11.87	Yes	No	0	0	8
320	R:R:N476	R:R:W480	25.99	No	Yes	0	6	9
321	R:R:E481	R:R:Q477	6.37	No	No	0	5	6
322	R:R:E479	R:R:N511	6.57	No	Yes	0	2	4
323	R:R:N511	R:R:W480	11.3	Yes	Yes	0	4	9
324	R:R:P513	R:R:W480	14.86	No	Yes	0	8	9
325	L:L:?1	R:R:W480	3.83	Yes	Yes	0	0	9
326	L:L:?1	R:R:E481	8.92	Yes	No	1	0	5
327	R:R:N511	R:R:S483	5.96	Yes	No	0	4	7
328	R:R:F484	R:R:V488	6.55	Yes	No	1	6	6
329	L:L:?1	R:R:F484	13.94	Yes	Yes	1	0	6
330	R:R:Q491	R:R:Y487	23.67	No	No	0	4	4
331	R:R:I509	R:R:Y487	4.84	No	No	0	4	4
332	R:R:C490	R:R:C507	7.28	No	No	0	9	9
333	R:R:D506	R:R:Q491	10.44	No	No	0	3	4
334	R:R:I496	R:R:N493	8.5	No	No	0	4	5
335	R:R:I509	R:R:R512	6.26	No	No	0	4	6
336	R:R:K510	R:R:N511	5.6	No	Yes	0	4	4
337	R:R:E518	R:R:L515	3.98	No	No	0	7	5
338	R:R:K519	R:R:L516	5.64	Yes	No	0	7	4
339	R:R:E518	R:R:V517	7.13	No	No	0	7	6
340	L:L:?1	R:R:E518	8.92	Yes	No	0	0	7
341	R:R:N521	W:W:?1	5.48	No	Yes	0	8	0
342	R:R:M525	W:W:?1	18.33	No	Yes	1	5	0
343	R:R:T528	W:W:?1	19.11	No	Yes	0	7	0
344	R:R:T534	R:R:W535	6.06	No	Yes	0	7	9
345	R:R:G191	R:R:Q192	3.29	No	No	0	5	4
346	R:R:L353	R:R:P263	3.28	No	No	0	8	9
347	R:R:L376	R:R:P306	3.28	No	Yes	0	8	5
348	R:R:L353	R:R:P352	3.28	No	No	0	8	7
349	R:R:E158	R:R:G162	3.27	No	No	0	7	3
350	R:R:C314	R:R:I293	3.27	Yes	Yes	0	9	8
351	R:R:A283	R:R:I317	3.25	No	No	0	5	7
352	R:R:S89	R:R:V139	3.23	No	No	0	8	7
353	R:R:A102	R:R:M131	3.22	No	Yes	0	7	5
354	R:R:A289	R:R:M286	3.22	No	No	0	7	4
355	R:R:A87	R:R:K133	3.21	No	Yes	0	4	6
356	R:R:S278	R:R:T241	3.2	No	No	0	8	7
357	R:R:S313	R:R:T311	3.2	No	No	0	7	7
358	R:R:G435	R:R:H433	3.18	No	Yes	0	5	8
359	R:R:E194	R:R:P196	3.14	No	No	0	6	7
360	R:R:F403	R:R:Y399	3.09	No	No	0	8	5
361	R:R:I293	R:R:V294	3.07	Yes	No	0	8	8
362	R:R:K105	R:R:S96	3.06	Yes	No	0	4	6
363	R:R:C507	R:R:Q491	3.05	No	No	0	9	4
364	R:R:M449	R:R:V423	3.04	No	No	0	9	7
365	R:R:I429	R:R:T425	3.04	Yes	No	0	7	7
366	R:R:F274	R:R:G328	3.01	No	No	0	9	8
367	R:R:F460	R:R:G461	3.01	No	No	0	5	5
368	R:R:G191	R:R:R199	3	No	No	0	5	4
369	R:R:G393	R:R:R400	3	No	Yes	0	9	9
370	R:R:L410	R:R:V411	2.98	No	No	0	4	5
371	R:R:L419	R:R:T336	2.95	No	No	0	7	7
372	R:R:I317	R:R:I320	2.94	No	No	0	7	5
373	R:R:I465	R:R:I520	2.94	Yes	No	0	5	5
374	R:R:Q123	R:R:S190	2.89	No	No	0	8	6
375	R:R:E101	R:R:S98	2.87	No	No	0	5	6
376	R:R:I445	R:R:L346	2.85	No	No	0	9	6
377	R:R:L426	R:R:M449	2.83	No	No	0	9	9
378	R:R:C295	R:R:R291	2.79	No	No	0	9	5
379	R:R:P352	R:R:Y350	2.78	No	No	0	7	7
380	R:R:L363	R:R:L367	2.77	No	Yes	0	4	5
381	R:R:P263	R:R:W339	2.7	No	Yes	0	9	9
382	R:R:A327	R:R:Y323	2.67	No	Yes	0	9	8
383	R:R:A345	R:R:Y350	2.67	No	No	0	7	7
384	R:R:L353	R:R:Q351	2.66	No	No	0	8	7
385	R:R:R302	R:R:S313	2.64	Yes	No	0	6	7
386	R:R:E194	R:R:N114	2.63	No	No	0	6	5
387	R:R:F274	R:R:V270	2.62	No	No	0	9	8
388	R:R:F332	R:R:V411	2.62	Yes	No	0	9	5
389	R:R:F369	R:R:V373	2.62	No	No	0	7	7
390	R:R:T372	R:R:Y322	2.5	No	Yes	0	9	9
391	R:R:V253	R:R:W256	2.45	No	No	0	5	7
392	R:R:V265	R:R:W256	2.45	No	No	0	8	7
393	R:R:F343	R:R:L346	2.44	No	No	0	9	6
394	R:R:F474	R:R:L405	2.44	Yes	No	0	6	8
395	R:R:N493	R:R:R161	2.41	No	No	0	5	5
396	R:R:E100	R:R:R74	2.33	No	No	0	4	4
397	R:R:G415	R:R:G416	2.11	Yes	No	0	8	5
398	R:R:F247	R:R:W537	2	No	No	0	8	8
399	R:R:F343	R:R:W339	2	No	Yes	0	9	9
400	R:R:C213	R:R:G214	1.96	No	No	0	9	8
401	R:R:A324	R:R:G277	1.95	No	No	0	7	6
402	R:R:A401	R:R:G402	1.95	No	No	0	6	5
403	R:R:A459	R:R:G456	1.95	No	No	0	7	7
404	R:R:A68	R:R:P69	1.87	No	No	0	5	4
405	R:R:A379	R:R:P306	1.87	No	Yes	0	6	5
406	R:R:A406	R:R:P407	1.87	No	No	0	5	9
407	R:R:G80	R:R:S81	1.86	No	No	0	5	5
408	R:R:G80	R:R:S189	1.86	No	No	0	5	5
409	R:R:G104	R:R:V107	1.84	No	No	0	4	4
410	R:R:G415	R:R:V333	1.84	Yes	No	0	8	9
411	R:R:G415	R:R:V414	1.84	Yes	No	0	8	5
412	R:R:G415	R:R:T336	1.82	Yes	No	0	8	7
413	R:R:G422	R:R:T425	1.82	No	No	0	8	7
414	R:R:P132	R:R:S89	1.78	No	No	0	9	8
415	R:R:G456	R:R:L419	1.71	No	No	0	7	7
416	R:R:A149	R:R:V121	1.7	No	No	0	4	7
417	R:R:A128	R:R:V182	1.7	No	No	0	8	4
418	R:R:A324	R:R:V276	1.7	No	No	0	7	5
419	R:R:A93	R:R:T90	1.68	No	No	0	5	5
420	R:R:D95	R:R:G94	1.68	Yes	No	0	5	5
421	R:R:A225	R:R:T223	1.68	No	No	0	4	5
422	R:R:D298	R:R:G299	1.68	Yes	No	0	7	4
423	R:R:G304	R:R:Q380	1.64	No	No	0	5	7
424	R:R:L367	R:R:P368	1.64	Yes	No	0	5	9
425	R:R:A338	R:R:I266	1.62	No	Yes	0	8	8
426	R:R:A289	R:R:I293	1.62	No	Yes	0	7	8
427	R:R:S385	R:R:V386	1.62	No	No	0	7	5
428	R:R:A524	R:R:I465	1.62	No	Yes	0	7	5
429	R:R:S358	R:R:T357	1.6	No	No	0	6	6
430	R:R:T200	R:R:V198	1.59	No	No	0	6	6
431	R:R:T495	R:R:V494	1.59	No	No	0	4	5
432	R:R:A272	R:R:L249	1.58	No	No	0	4	6
433	R:R:E71	R:R:P72	1.57	No	No	0	7	4
434	R:R:A67	R:R:D137	1.54	No	No	0	1	4
435	R:R:A254	R:R:D255	1.54	No	No	0	8	8
436	R:R:I316	R:R:V319	1.54	No	No	0	5	7
437	R:R:I420	R:R:V423	1.54	No	No	0	5	7
438	R:R:I445	R:R:T448	1.52	No	No	0	9	8
439	R:R:A155	R:R:E158	1.51	No	No	0	5	7
440	R:R:L367	R:R:S366	1.5	Yes	No	0	5	7
441	R:R:L106	R:R:V107	1.49	No	No	0	8	4
442	R:R:L367	R:R:V370	1.49	Yes	No	0	5	5
443	R:R:D229	R:R:S232	1.47	No	No	0	6	4
444	R:R:I429	R:R:I445	1.47	Yes	No	0	7	9
445	R:R:I420	R:R:M424	1.46	No	No	0	5	5
446	R:R:D506	R:R:V494	1.46	No	No	0	3	5
447	R:R:E100	R:R:S98	1.44	No	No	0	4	6
448	R:R:Q351	R:R:S354	1.44	No	No	0	7	7
449	R:R:I454	R:R:L450	1.43	No	No	0	6	6
450	R:R:I429	R:R:N432	1.42	Yes	No	0	7	6
451	R:R:K430	R:R:N446	1.4	No	No	0	8	7
452	R:R:M449	R:R:N446	1.4	No	No	0	9	7
453	R:R:A264	R:R:F252	1.39	No	No	0	9	9
454	R:R:D287	R:R:M286	1.39	No	No	0	5	4
455	R:R:A531	R:R:F462	1.39	No	Yes	0	6	7
456	R:R:E292	R:R:I293	1.37	No	Yes	0	5	8
457	R:R:E135	R:R:K133	1.35	No	Yes	0	6	6
458	R:R:E508	R:R:K510	1.35	No	No	0	4	4
459	R:R:D165	R:R:D95	1.33	No	Yes	0	4	5
460	R:R:E208	R:R:L303	1.33	No	No	0	4	3
461	R:R:H433	R:R:I429	1.33	Yes	Yes	0	8	7
462	R:R:D97	R:R:E101	1.3	No	No	0	3	5
463	R:R:S514	R:R:Y472	1.27	No	No	0	7	7
464	R:R:F462	R:R:I465	1.26	Yes	Yes	0	7	5
465	R:R:F523	R:R:I465	1.26	No	Yes	0	6	5
466	R:R:T348	R:R:Y350	1.25	No	No	0	7	7
467	R:R:F460	R:R:L412	1.22	No	No	0	5	7
468	R:R:D486	R:R:R482	1.19	No	No	0	4	3
469	R:R:E160	R:R:R485	1.16	No	No	0	4	5
470	R:R:D201	R:R:W206	1.12	No	Yes	0	5	4
471	R:R:F471	R:R:F474	1.07	No	Yes	0	4	6

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	R:R:C78	4.955	4	4	9
2	R:R:Y85	7.25	4	0	9
3	R:R:D95	3.436	5	2	5
4	R:R:K105	7.582	5	2	4
5	R:R:W109	6.934	5	2	7
6	R:R:W119	10.375	4	0	9
7	R:R:L125	5.7975	4	0	7
8	R:R:Y130	7.788	5	2	7
9	R:R:M131	3.73	4	0	5
10	R:R:K133	4.506	5	6	6
11	R:R:T150	6.6225	4	0	7
12	R:R:R151	7.464	5	7	5
13	R:R:W163	12.05	5	7	8
14	R:R:F166	7.968	5	2	6
15	R:R:I185	5.308	5	4	4
16	R:R:F187	10.182	5	4	6
17	R:R:N202	4.645	4	1	5
18	R:R:W206	8.43	4	0	4
19	R:R:Y207	10.45	4	1	7
20	R:R:E211	7.082	5	0	5
21	R:R:N219	7.568	5	0	7
22	R:R:F222	7.02	6	0	6
23	R:R:Y262	7.13	4	3	9
24	R:R:I266	5.1	5	3	8
25	R:R:Y269	7.53	4	3	8
26	R:R:W281	6.03833	6	1	7
27	R:R:F285	6.0125	4	9	8
28	R:R:I293	2.3325	4	0	8
29	R:R:R296	6.824	5	1	6
30	R:R:D298	7.565	4	0	7
31	R:R:R302	7.595	4	1	6
32	R:R:E305	8.045	4	1	7
33	R:R:P306	5.9025	4	0	5
34	R:R:C314	5.2025	4	1	9
35	R:R:F318	8.655	4	1	9
36	R:R:Y322	5.14	5	1	9
37	R:R:Y323	5.3675	4	0	8
38	R:R:W331	11.948	5	3	9
39	R:R:F332	5.425	4	11	9
40	R:R:W339	9.1625	4	0	9
41	R:R:F360	6.9	4	3	9
42	R:R:H361	6.9525	4	3	9
43	R:R:L367	1.85	4	0	5
44	R:R:F391	7.462	5	1	8
45	R:R:Y394	9.386	5	1	5
46	R:R:K395	6.3875	4	1	3
47	R:R:R400	6.1475	4	1	9
48	R:R:G415	1.9025	4	0	8
49	R:R:I429	1.815	4	0	7
50	R:R:H433	4.38	4	0	8
51	R:R:F462	3.7375	4	0	7
52	R:R:I465	1.77	4	0	5
53	R:R:H470	8.174	5	1	7
54	R:R:F474	5.446	5	1	6
55	R:R:W480	13.995	4	0	9
56	R:R:F484	7.7525	4	1	6
57	R:R:N511	7.3575	4	0	4
58	R:R:K519	9.9825	4	8	7
59	R:R:W535	11.844	5	0	9
60	R:R:V536	5.465	4	10	8
61	L:L:?1	9.47222	9	1	0
62	W:W:?1	10.5778	9	1	0

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:M131	R:R:Y85	12.748	3.59	Yes	Yes	0	5	9
2	R:R:M131	R:R:Y130	17.5047	3.59	Yes	Yes	0	5	7
3	R:R:L92	R:R:V129	31.1763	4.47	No	No	0	8	7
4	R:R:L141	R:R:L92	12.8832	4.15	No	No	0	7	8
5	R:R:L92	R:R:R173	16.5534	3.64	No	No	0	8	4
6	R:R:Q123	R:R:W119	21.3079	19.71	No	Yes	0	8	9
7	R:R:F187	R:R:Q123	24.1321	21.08	Yes	No	0	6	8
8	R:R:F187	R:R:I185	28.7281	6.28	Yes	Yes	4	6	4
9	R:R:F166	R:R:V129	23.6497	3.93	Yes	No	2	6	7
10	R:R:W109	R:R:Y130	22.6485	6.75	Yes	Yes	2	7	7
11	R:R:L126	R:R:W109	25.8807	3.42	No	Yes	0	9	7
12	R:R:E211	R:R:V210	87.0857	4.28	Yes	No	0	5	5
13	R:R:C118	R:R:E211	100	7.6	No	Yes	0	9	5
14	R:R:C118	R:R:C154	99.8425	7.28	No	No	0	9	9
15	R:R:C154	R:R:T150	99.3569	5.07	No	Yes	0	9	7
16	R:R:I122	R:R:T150	55.2175	7.6	No	Yes	0	7	7
17	R:R:I122	R:R:L125	28.8345	5.71	No	Yes	0	7	7
18	R:R:L125	R:R:L167	21.3201	4.15	Yes	No	0	7	7
19	R:R:F166	R:R:L167	30.7628	15.83	Yes	No	0	6	7
20	R:R:R151	R:R:T150	43.6682	9.06	Yes	Yes	0	5	7
21	R:R:L125	R:R:R151	29.4754	3.64	Yes	Yes	0	7	5
22	R:R:R151	R:R:W163	13.1604	12	Yes	Yes	7	5	8
23	R:R:L167	R:R:W163	11.1036	4.56	No	Yes	0	7	8
24	R:R:I122	R:R:L126	26.2543	9.99	No	No	0	7	9
25	R:R:Q192	R:R:W119	11.7611	4.38	No	Yes	0	4	9
26	R:R:G191	R:R:Q192	10.7931	3.29	No	No	0	5	4
27	R:R:E211	R:R:R117	18.1578	9.3	Yes	No	0	5	5
28	R:R:R117	R:R:W206	17.0668	20.99	No	Yes	0	5	4
29	R:R:L125	R:R:L146	36.9266	9.69	Yes	No	0	7	6
30	R:R:D172	R:R:R173	11.0958	3.57	No	No	0	4	4
31	R:R:L146	R:R:N180	36.0617	6.87	No	No	0	6	5
32	R:R:I185	R:R:V182	33.6135	4.61	Yes	No	0	4	4
33	R:R:N180	R:R:V182	35.219	7.39	No	No	0	5	4
34	R:R:V210	R:R:Y207	84.4456	5.05	No	Yes	1	5	7
35	R:R:F484	R:R:Y207	87.4694	6.19	Yes	Yes	1	6	7
36	L:L:?1	R:R:F484	80.1779	13.94	Yes	Yes	1	0	6
37	R:R:F222	R:R:N219	18.3907	8.46	Yes	Yes	0	6	7
38	L:L:?1	R:R:N219	14.1628	12.94	Yes	Yes	0	0	7
39	R:R:W281	W:W:?1	14.3801	4.54	Yes	Yes	1	7	0
40	R:R:Y394	W:W:?1	14.8979	7.01	Yes	Yes	1	5	0
41	L:L:?1	R:R:Y394	73.4241	8.68	Yes	Yes	1	0	5
42	R:R:F252	R:R:F268	14.0242	8.57	No	No	0	9	8
43	R:R:F268	R:R:Y269	20.371	5.16	No	Yes	0	8	8
44	R:R:W331	R:R:Y269	13.6239	14.47	Yes	Yes	3	9	8
45	R:R:W331	R:R:W365	45.2781	11.25	Yes	No	3	9	9
46	R:R:W365	R:R:Y323	60.4034	7.72	No	Yes	0	9	8
47	R:R:P368	R:R:Y323	61.8049	6.95	No	Yes	0	9	8
48	R:R:M326	R:R:P368	63.5069	3.35	No	No	0	8	9
49	R:R:M326	R:R:Y322	64.5015	5.99	No	Yes	0	8	9
50	R:R:F391	R:R:Y322	59.5951	4.13	Yes	Yes	1	8	9
51	R:R:F391	R:R:Y394	55.5102	8.25	Yes	Yes	1	8	5
52	R:R:H361	R:R:Y269	11.974	5.44	Yes	Yes	3	9	8
53	R:R:H361	R:R:W365	14.7682	10.58	Yes	No	3	9	9
54	R:R:I266	R:R:W331	34.0182	7.05	Yes	Yes	3	8	9
55	R:R:I266	R:R:L335	32.5867	5.71	Yes	No	0	8	8
56	R:R:L335	R:R:W339	32.1188	21.64	No	Yes	0	8	9
57	R:R:W339	R:R:W535	13.7936	10.31	Yes	Yes	0	9	9
58	R:R:F455	R:R:W535	11.5848	17.04	No	Yes	0	8	9
59	R:R:R296	R:R:R302	19.2511	9.6	Yes	Yes	1	6	6
60	R:R:E305	R:R:R302	12.728	13.96	Yes	Yes	1	7	6
61	R:R:E305	R:R:V381	14.4821	4.28	Yes	No	1	7	8
62	R:R:F318	R:R:V381	10.5525	15.73	Yes	No	1	9	8
63	R:R:F343	R:R:L346	10.4771	2.44	No	No	0	9	6
64	R:R:F343	R:R:W339	14.9035	2	No	Yes	0	9	9
65	R:R:F391	W:W:?1	13.5485	14.57	Yes	Yes	1	8	0

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:F484	R:R:Y207	6.19	1	Yes	Yes	6	7	1	2
R:R:V488	R:R:Y207	7.57	1	No	Yes	6	7	2	2
R:R:I215	R:R:P220	5.08	0	No	No	5	8	2	2
R:R:I215	R:R:M301	7.29	0	No	No	5	4	2	1
R:R:N219	R:R:P220	6.52	0	Yes	No	7	8	1	2
R:R:L221	R:R:N219	5.49	0	No	Yes	6	7	2	1
R:R:F222	R:R:N219	8.46	0	Yes	Yes	6	7	2	1
R:R:N219	R:R:V386	4.43	0	Yes	No	7	5	1	2
L:L:?1	R:R:N219	12.94	1	Yes	Yes	0	7	0	1
R:R:F484	R:R:P220	4.33	1	Yes	No	6	8	1	2
R:R:L221	R:R:P513	6.57	0	No	No	6	8	2	2
R:R:F222	R:R:P513	8.67	0	Yes	No	6	8	2	2
R:R:F222	R:R:L515	3.65	0	Yes	No	6	5	2	2
R:R:L303	R:R:M301	4.24	0	No	No	3	4	2	1
L:L:?1	R:R:M301	5.71	1	Yes	No	0	4	0	1
R:R:K395	R:R:Q380	4.07	1	Yes	No	3	7	1	2
R:R:N396	R:R:Q380	11.88	1	No	No	7	7	2	2
R:R:D382	R:R:Y394	6.9	0	No	Yes	9	5	2	1
R:R:D384	R:R:V386	5.84	0	No	No	8	5	2	2
R:R:D384	R:R:Y394	16.09	0	No	Yes	8	5	2	1
R:R:F391	R:R:Y394	8.25	1	Yes	Yes	8	5	2	1
R:R:F391	W:W:?1	14.57	1	Yes	Yes	8	0	2	2
L:L:?1	R:R:Y394	8.68	1	Yes	Yes	0	5	0	1
R:R:Y394	W:W:?1	7.01	1	Yes	Yes	5	0	1	2
R:R:K395	R:R:N396	6.99	1	Yes	No	3	7	1	2
R:R:E481	R:R:K395	4.05	1	No	Yes	5	3	1	1
L:L:?1	R:R:K395	10.44	1	Yes	Yes	0	3	0	1
R:R:D473	R:R:R400	10.72	0	No	Yes	8	9	1	2
L:L:?1	R:R:D473	11.87	1	Yes	No	0	8	0	1
R:R:N476	R:R:W480	25.99	0	No	Yes	6	9	2	1
R:R:E481	R:R:Q477	6.37	1	No	No	5	6	1	2
R:R:N511	R:R:W480	11.3	0	Yes	Yes	4	9	2	1
R:R:P513	R:R:W480	14.86	0	No	Yes	8	9	2	1
L:L:?1	R:R:W480	3.83	1	Yes	Yes	0	9	0	1
L:L:?1	R:R:E481	8.92	1	Yes	No	0	5	0	1
R:R:F484	R:R:V488	6.55	1	Yes	No	6	6	1	2
L:L:?1	R:R:F484	13.94	1	Yes	Yes	0	6	0	1
R:R:E518	R:R:L515	3.98	0	No	No	7	5	1	2
R:R:E518	R:R:V517	7.13	0	No	No	7	6	1	2
L:L:?1	R:R:E518	8.92	1	Yes	No	0	7	0	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:I234	R:R:W281	7.05	0	No	Yes	7	7	2	1
R:R:V321	R:R:W281	4.9	0	No	Yes	8	7	2	1
R:R:I389	R:R:W281	5.87	0	No	Yes	9	7	2	1
R:R:L522	R:R:W281	4.56	0	No	Yes	7	7	2	1
R:R:M525	R:R:W281	9.31	1	No	Yes	5	7	1	1
R:R:W281	W:W:?1	4.54	1	Yes	Yes	7	0	1	0
R:R:F318	R:R:Y322	7.22	1	Yes	Yes	9	9	2	2
R:R:F318	R:R:F391	6.43	1	Yes	Yes	9	8	2	1
R:R:F318	R:R:V392	5.24	1	Yes	No	9	9	2	2
R:R:F391	R:R:Y322	4.13	1	Yes	Yes	8	9	1	2
R:R:L325	R:R:M525	4.24	0	No	No	5	5	2	1
R:R:D382	R:R:Y394	6.9	0	No	Yes	9	5	2	1
R:R:D384	R:R:Y394	16.09	0	No	Yes	8	5	2	1
R:R:F391	R:R:V392	3.93	1	Yes	No	8	9	1	2
R:R:F391	R:R:Y394	8.25	1	Yes	Yes	8	5	1	1
R:R:F391	W:W:?1	14.57	1	Yes	Yes	8	0	1	0
L:L:?1	R:R:Y394	8.68	1	Yes	Yes	0	5	2	1
R:R:Y394	W:W:?1	7.01	1	Yes	Yes	5	0	1	0
R:R:H470	R:R:R400	3.39	1	Yes	Yes	7	9	1	2
R:R:F474	R:R:R400	7.48	1	Yes	Yes	6	9	2	2
R:R:H470	R:R:V404	12.45	1	Yes	No	7	7	1	1
R:R:V404	W:W:?1	5.94	1	No	Yes	7	0	1	0
R:R:I408	R:R:V463	4.61	0	No	No	7	7	1	2
R:R:I408	W:W:?1	9.96	0	No	Yes	7	0	1	0
R:R:F462	R:R:T528	7.78	0	Yes	No	7	7	2	1
R:R:H470	R:R:T466	6.85	1	Yes	No	7	8	1	2
R:R:C469	R:R:N521	11.02	0	No	No	7	8	2	1
R:R:F474	R:R:H470	7.92	1	Yes	Yes	6	7	2	1
R:R:H470	W:W:?1	10.26	1	Yes	Yes	7	0	1	0
R:R:N521	W:W:?1	5.48	0	No	Yes	8	0	1	0
R:R:M525	W:W:?1	18.33	1	No	Yes	5	0	1	0
R:R:T528	W:W:?1	19.11	0	No	Yes	7	0	1	0

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	6XBL_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	3.35
Number of Linked Nodes	424
Number of Links	471
Number of Hubs	62
Number of Links mediated by Hubs	230
Number of Communities	11
Number of Nodes involved in Communities	73
Number of Links involved in Communities	96

Path Summary
Number Of Nodes in MetaPath	66
Number Of Links MetaPath	65
Number of Shortest Paths	156636
Length Of Smallest Path	3
Average Path Length	18.8752
Length of Longest Path	49
Minimum Path Strength	1.26
Average Path Strength	7.2894
Maximum Path Strength	20.425
Minimum Path Correlation	0.7
Average Path Correlation	0.963393
Maximum Path Correlation	1
Minimum % Of Corr. Nodes	3.125
Average % Of Corr. Nodes	58.8708
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	47.8185
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function	• patched binding • protein binding • binding • signaling receptor binding • molecular transducer activity • G protein-coupled receptor activity • transmembrane signaling receptor activity • signaling receptor activity • protein serine/threonine kinase activity • enzyme regulator activity • catalytic activity, acting on a protein • kinase activity • cyclic nucleotide-dependent protein kinase activity • protein kinase activity • cAMP-dependent protein kinase activity • transferase activity • enzyme inhibitor activity • protein kinase regulator activity • phosphotransferase activity, alcohol group as acceptor • transferase activity, transferring phosphorus-containing groups • cAMP-dependent protein kinase regulator activity • protein kinase inhibitor activity • molecular function inhibitor activity • molecular function regulator activity • catalytic activity • cAMP-dependent protein kinase inhibitor activity • protein serine/threonine kinase inhibitor activity • kinase inhibitor activity • kinase regulator activity • molecular sequestering activity • protein sequestering activity • sterol binding • oxysterol binding • steroid binding • lipid binding • protein kinase A catalytic subunit binding • protein kinase A binding • kinase binding • enzyme binding • protein kinase binding • cellular response to stimulus • response to sterol • response to stimulus • response to lipid • response to alcohol • response to oxygen-containing compound • response to cholesterol • cellular response to oxygen-containing compound • cellular response to chemical stimulus • cellular response to alcohol • response to chemical • cellular response to lipid • cellular process • cellular response to sterol
Gene Ontology	Biological Process	• cellular response to stimulus • response to sterol • response to stimulus • response to lipid • response to alcohol • response to oxygen-containing compound • response to cholesterol • cellular response to oxygen-containing compound • cellular response to chemical stimulus • cellular response to alcohol • response to chemical • cellular response to lipid • cellular process • cellular response to sterol • cellular response to cholesterol • developmental process • cellular developmental process • cell differentiation • cell fate specification • cell fate commitment • neuroblast proliferation • multicellular organismal process • cell population proliferation • nervous system development • generation of neurons • neurogenesis • multicellular organism development • anatomical structure development • neural precursor cell proliferation • system development • pattern specification process • digestive system development • tube development • midgut development • digestive tract development • regulation of protein stability • biological regulation • regulation of biological quality • protein stabilization • central nervous system development • multicellular organismal-level homeostasis • homeostatic process • homeostasis of number of cells within a tissue • anatomical structure homeostasis • tissue homeostasis • homeostasis of number of cells • mammary gland epithelial cell differentiation • epithelium development • mammary gland development • gland development • animal organ development • tissue development • epithelial cell differentiation • mammary gland epithelium development • regulation of biological process • signaling • cell-cell signaling • epithelial-mesenchymal cell signaling • cell communication • muscle cell migration • myoblast migration • cell migration • cell motility • regulation of biosynthetic process • regulation of cellular process • positive regulation of biological process • regulation of macromolecule metabolic process • gene expression • macromolecule biosynthetic process • positive regulation of macromolecule biosynthetic process • regulation of gene expression • positive regulation of metabolic process • biosynthetic process • positive regulation of gene expression • positive regulation of biosynthetic process • regulation of macromolecule biosynthetic process • metabolic process • positive regulation of macromolecule metabolic process • macromolecule metabolic process • regulation of metabolic process • positive regulation of cellular process • anatomical structure morphogenesis • pancreas morphogenesis • pancreas development • animal organ morphogenesis • apoptotic process • cell death • programmed cell death • regulation of protein modification process • regulation of protein phosphorylation • negative regulation of biological process • negative regulation of phosphate metabolic process • regulation of primary metabolic process • regulation of phosphate metabolic process • phosphate-containing compound metabolic process • negative regulation of protein modification process • negative regulation of cellular process • protein metabolic process • protein modification process • phosphorus metabolic process • negative regulation of protein metabolic process • negative regulation of macromolecule metabolic process • protein phosphorylation • phosphorylation • regulation of protein metabolic process • negative regulation of metabolic process • primary metabolic process • negative regulation of protein phosphorylation • macromolecule modification • negative regulation of phosphorus metabolic process • regulation of phosphorylation • regulation of phosphorus metabolic process • negative regulation of phosphorylation • cerebellum morphogenesis • cerebellar cortex morphogenesis • head development • hindbrain morphogenesis • brain development • cerebellar cortex development • cerebellum development • metencephalon development • hindbrain development • protein localization • establishment of protein localization • cellular localization • nitrogen compound transport • nucleocytoplasmic transport • transport • nuclear transport • intracellular transport • protein localization to nucleus • establishment of localization • localization • import into nucleus • establishment of protein localization to organelle • protein transport • cellular macromolecule localization • macromolecule localization • protein localization to organelle • establishment of localization in cell • protein import into nucleus • intracellular protein transport • epidermis development • molting cycle process • hair cycle • epidermis morphogenesis • morphogenesis of an epithelium • tissue morphogenesis • skin development • skin epidermis development • hair follicle development • molting cycle • hair cycle process • hair follicle morphogenesis • regulation of localization • regulation of protein localization • positive regulation of nucleocytoplasmic transport • positive regulation of establishment of protein localization • regulation of protein localization to nucleus • positive regulation of protein transport • regulation of protein import into nucleus • positive regulation of intracellular transport • regulation of intracellular transport • regulation of transport • positive regulation of protein localization to nucleus • regulation of establishment of protein localization • positive regulation of protein import into nucleus • regulation of nucleocytoplasmic transport • regulation of protein transport • positive regulation of transport • regulation of cellular localization • positive regulation of protein localization • regulation of intracellular protein transport • positive regulation of intracellular protein transport • embryo development ending in birth or egg hatching • chordate embryonic development • embryo development • in utero embryonic development • forebrain development • pallium development • cerebral cortex development • telencephalon development • astrocyte differentiation • cell development • astrocyte activation • glial cell development • astrocyte development • gliogenesis • response to stress • defense response • cell activation • glial cell differentiation • glial cell activation • inflammatory response • neuroinflammatory response • brain morphogenesis • forebrain morphogenesis • neural tube development • regionalization • dorsal/ventral pattern formation • dorsal/ventral neural tube patterning • neural tube patterning • endocrine system development • type B pancreatic cell development • epithelial cell development • endocrine pancreas development • enteroendocrine cell differentiation • type B pancreatic cell differentiation • RNA metabolic process • negative regulation of RNA biosynthetic process • RNA biosynthetic process • nucleobase-containing compound metabolic process • DNA-templated transcription • nucleic acid biosynthetic process • regulation of RNA metabolic process • transcription by RNA polymerase II • negative regulation of nucleobase-containing compound metabolic process • regulation of nucleobase-containing compound metabolic process • regulation of RNA biosynthetic process • regulation of transcription by RNA polymerase II • negative regulation of DNA-templated transcription • negative regulation of transcription by RNA polymerase II • nucleobase-containing compound biosynthetic process • nucleic acid metabolic process • negative regulation of biosynthetic process • negative regulation of macromolecule biosynthetic process • regulation of DNA-templated transcription • negative regulation of RNA metabolic process • multicellular organism growth • developmental growth • growth • positive regulation of DNA-templated transcription • positive regulation of nucleobase-containing compound metabolic process • positive regulation of transcription by RNA polymerase II • positive regulation of RNA metabolic process • positive regulation of RNA biosynthetic process • heart morphogenesis • embryonic heart tube development • tube morphogenesis • embryonic heart tube morphogenesis • heart looping • determination of bilateral symmetry • epithelial tube morphogenesis • embryonic organ development • determination of left/right symmetry • specification of symmetry • embryonic organ morphogenesis • heart development • embryonic morphogenesis • determination of heart left/right asymmetry • circulatory system development • left/right pattern formation • regulation of somatic stem cell population maintenance • regulation of developmental process • regulation of stem cell population maintenance • stem cell population maintenance • somatic stem cell population maintenance • regulation of multicellular organismal process • maintenance of cell number • ossification • osteoblast differentiation • cell surface receptor signaling pathway • smoothened signaling pathway • signal transduction • myotube cell development • skeletal muscle fiber development • skeletal muscle tissue development • muscle cell differentiation • myotube differentiation • striated muscle tissue development • muscle structure development • skeletal muscle organ development • striated muscle cell development • muscle cell development • muscle tissue development • muscle organ development • striated muscle cell differentiation • cardiac atrium morphogenesis • cardiac chamber morphogenesis • cardiac atrium development • cardiac septum development • cardiac septum morphogenesis • cardiac chamber development • atrial septum morphogenesis • atrial septum development • mesonephric epithelium development • kidney epithelium development • branching morphogenesis of an epithelial tube • nephron tubule morphogenesis • regulation of kidney development • regulation of branching involved in ureteric bud morphogenesis • positive regulation of developmental process • nephron development • regulation of morphogenesis of a branching structure • regulation of animal organ morphogenesis • positive regulation of multicellular organismal process • mesonephric tubule development • renal tubule morphogenesis • nephron morphogenesis • nephron epithelium morphogenesis • nephron tubule development • renal system development • ureteric bud morphogenesis • positive regulation of morphogenesis of an epithelium • branching involved in ureteric bud morphogenesis • renal tubule development • regulation of morphogenesis of an epithelium • regulation of anatomical structure morphogenesis • nephron epithelium development • ureteric bud development • mesonephros development • kidney morphogenesis • morphogenesis of a branching structure • positive regulation of branching involved in ureteric bud morphogenesis • mesonephric tubule morphogenesis • kidney development • morphogenesis of a branching epithelium • odontogenesis of dentin-containing tooth • odontogenesis • negative regulation of programmed cell death • regulation of apoptotic process • regulation of programmed cell death • negative regulation of apoptotic process • ventral midline determination • ventral midline development • central nervous system neuron differentiation • neuron differentiation • positive regulation of cell communication • positive regulation of signal transduction • regulation of signal transduction • positive regulation of response to stimulus • positive regulation of smoothened signaling pathway • regulation of smoothened signaling pathway • regulation of signaling • regulation of response to stimulus • regulation of cell communication • positive regulation of signaling • regulation of cell differentiation • regulation of epithelial cell differentiation • negative regulation of cell differentiation • regulation of multicellular organismal development • negative regulation of epithelial cell differentiation • negative regulation of developmental process • spinal cord dorsal/ventral patterning • spinal cord development • spinal cord patterning • positive regulation of mesenchymal cell proliferation • positive regulation of cell population proliferation • regulation of mesenchymal cell proliferation • regulation of cell population proliferation • mesenchymal cell proliferation • positive regulation of epithelial cell proliferation • regulation of epithelial cell proliferation • epithelial cell proliferation • diencephalon development • thalamus development • stem cell development • neural crest cell differentiation • neural crest cell development • mesenchyme development • mesenchymal cell migration • stem cell differentiation • ameboidal-type cell migration • mesenchymal cell differentiation • neural crest cell migration • commissural neuron axon guidance • axonogenesis • cell projection organization • plasma membrane bounded cell projection morphogenesis • neuron projection development • cell morphogenesis • cellular component organization • cell projection morphogenesis • neuron projection morphogenesis • cellular component organization or biogenesis • plasma membrane bounded cell projection organization • axon guidance • axon development • cell morphogenesis involved in neuron differentiation • neuron projection guidance • neuron development • left/right axis specification • axis specification • regulation of heart morphogenesis • blood vessel morphogenesis • vasculogenesis • vasculature development • blood vessel development • mesenchymal to epithelial transition involved in renal vesicle formation • renal vesicle morphogenesis • metanephric renal vesicle morphogenesis • renal vesicle development • metanephros development • metanephric renal vesicle formation • metanephros morphogenesis • metanephric nephron development • mesenchymal to epithelial transition involved in metanephric renal vesicle formation • mesenchymal to epithelial transition involved in metanephros morphogenesis • epithelial cell differentiation involved in kidney development • mesenchymal to epithelial transition • metanephric nephron morphogenesis • cell differentiation involved in metanephros development • cell differentiation involved in kidney development • anatomical structure formation involved in morphogenesis • renal vesicle formation • positive regulation of locomotion • regulation of cell motility • positive regulation of cell migration • regulation of locomotion • positive regulation of cell motility • regulation of cell migration • locomotion • regulation of growth • regulation of developmental growth • positive regulation of organ growth • organ growth • positive regulation of growth • regulation of organ growth • positive regulation of developmental growth • regulation of multicellular organism growth • positive regulation of multicellular organism growth • dentate gyrus development • hippocampus development • limbic system development • smooth muscle tissue development • regulation of molecular function • regulation of DNA binding • regulation of binding • negative regulation of binding • negative regulation of molecular function • negative regulation of DNA binding • response to inositol • negative regulation of gene expression • regulation of hair cycle • regulation of hair follicle development • negative regulation of hair follicle development • negative regulation of multicellular organismal process • detection of stimulus • contact inhibition • detection of cell density • detection of biotic stimulus • response to biotic stimulus • lateral mesoderm development • determination of left/right asymmetry in lateral mesoderm • mesoderm development • dopaminergic neuron differentiation • positive regulation of nervous system development • regulation of neuroblast proliferation • regulation of neurogenesis • regulation of cell development • regulation of nervous system development • positive regulation of cell differentiation • positive regulation of neurogenesis • regulation of neural precursor cell proliferation • positive regulation of cell development • positive regulation of neural precursor cell proliferation • positive regulation of neuroblast proliferation • anterior/posterior pattern specification • somite development • extracellular exosome • membrane-bounded organelle • extracellular vesicle • cellular anatomical structure • extracellular organelle • extracellular region • organelle • extracellular space • vesicle • extracellular membrane-bounded organelle • cell projection • ciliary tip • cilium • plasma membrane bounded cell projection
Gene Ontology	Cellular Component	• extracellular exosome • membrane-bounded organelle • extracellular vesicle • cellular anatomical structure • extracellular organelle • extracellular region • organelle • extracellular space • vesicle • extracellular membrane-bounded organelle • cell projection • ciliary tip • cilium • plasma membrane bounded cell projection • somatodendritic compartment • dendrite • dendritic tree • neuron projection • intracellular anatomical structure • membrane • intracellular vesicle • intracellular membrane-bounded organelle • intracellular organelle • cytoplasmic vesicle membrane • bounding membrane of organelle • cytoplasmic vesicle • vesicle membrane • endocytic vesicle membrane • cytoplasm • organelle membrane • endocytic vesicle • Golgi apparatus • endomembrane system • endoplasmic reticulum-Golgi intermediate compartment • non-motile cilium • 9+0 non-motile cilium • microtubule organizing center • cytoskeleton • membraneless organelle • centriole • intracellular membraneless organelle • microtubule cytoskeleton • cell periphery • plasma membrane • ciliary membrane • plasma membrane region • cell projection membrane • endosome • late endosome • endoplasmic reticulum • D2 dopamine receptor binding • protein binding • binding • signaling receptor binding • G protein-coupled receptor binding • dopamine receptor binding • phosphorus-oxygen lyase activity • enzyme regulator activity • cyclase regulator activity • molecular function regulator activity • cyclase activity • adenylate cyclase regulator activity • lyase activity • catalytic activity • adenylate cyclase activity • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • cation binding • magnesium ion binding • metal ion binding • GDP binding • G protein-coupled serotonin receptor binding • protein-containing complex binding • G-protein beta/gamma-subunit complex binding • pyrophosphatase activity • GTPase activity • G protein activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • adenylate cyclase-inhibiting serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • cell communication • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular process • signal transduction • response to hormone • response to chemical • response to endogenous stimulus • response to peptide hormone • response to oxygen-containing compound • response to nitrogen compound • cell division • leukocyte migration • immune system process • mononuclear cell migration • lymphocyte migration • cell migration • T cell migration • cell motility • regulation of steroid biosynthetic process • regulation of cholesterol biosynthetic process • regulation of cholesterol metabolic process • steroid metabolic process • regulation of lipid metabolic process • sterol metabolic process • positive regulation of biological process • cholesterol metabolic process • lipid biosynthetic process • alcohol metabolic process • regulation of primary metabolic process • positive regulation of metabolic process • regulation of small molecule metabolic process • positive regulation of biosynthetic process • positive regulation of lipid metabolic process • small molecule metabolic process • steroid biosynthetic process • positive regulation of cellular process • regulation of biosynthetic process • secondary alcohol biosynthetic process • regulation of alcohol biosynthetic process • small molecule biosynthetic process • regulation of steroid metabolic process • cholesterol biosynthetic process • positive regulation of cholesterol biosynthetic process • primary metabolic process • secondary alcohol metabolic process • positive regulation of steroid biosynthetic process • biosynthetic process • sterol biosynthetic process • positive regulation of lipid biosynthetic process • regulation of sterol biosynthetic process • alcohol biosynthetic process • positive regulation of cholesterol metabolic process • positive regulation of steroid metabolic process • metabolic process • regulation of lipid biosynthetic process • positive regulation of small molecule metabolic process • regulation of metabolic process • positive regulation of alcohol biosynthetic process • positive regulation of sterol biosynthetic process • lipid metabolic process • regulation of cytoskeleton organization • regulation of cellular component organization • microtubule cytoskeleton organization • regulation of mitotic spindle organization • mitotic cell cycle • cellular component organization • cell cycle • cellular component organization or biogenesis • regulation of cell cycle • microtubule cytoskeleton organization involved in mitosis • spindle organization • cell cycle process • regulation of cell cycle process • regulation of microtubule-based process • regulation of spindle organization • regulation of organelle organization • mitotic spindle organization • organelle organization • mitotic cell cycle process • microtubule-based process • cytoskeleton organization • regulation of microtubule cytoskeleton organization • protein localization • positive regulation of protein localization to cell periphery • regulation of localization • protein localization to cell periphery • cellular localization • regulation of protein localization • positive regulation of protein localization to cell cortex • regulation of protein localization to cell periphery • localization • regulation of cellular localization • regulation of protein localization to cell cortex • cellular macromolecule localization • macromolecule localization • positive regulation of protein localization • protein localization to cell cortex • response to ketone • response to prostaglandin • response to lipid • response to alcohol • response to prostaglandin E • cellular response to forskolin • cellular response to oxygen-containing compound • cellular response to chemical stimulus • cellular response to alcohol • response to forskolin • cellular response to lipid • cellular response to ketone • midbody • nucleus • membrane-enclosed lumen • nucleolus • intracellular organelle lumen • organelle lumen • nuclear lumen • cell cortex • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • centrosome • centriolar satellite • cytosol • nucleoplasm • vacuolar membrane • lytic vacuole • vacuole • lytic vacuole membrane • lysosomal membrane • lysosome • ciliary basal body • enzyme binding • GTPase binding • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • multicellular organismal process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development • anatomical structure development • sensory system development • system development • cell population proliferation • cellular response to prostaglandin stimulus • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to hormone stimulus • small GTPase-mediated signal transduction • Ras protein signal transduction • intracellular signal transduction • intracellular signaling cassette • phospholipase C-activating G protein-coupled receptor signaling pathway • cellular response to nitrogen compound • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to monoamine stimulus • synaptic signaling • cellular response to acetylcholine • cell-cell signaling • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • photoreceptor disc membrane • photoreceptor outer segment • photoreceptor cell cilium • synapse • cell junction • G-protein beta-subunit binding • fibroblast proliferation
SCOP2	Domain Identifier	• G protein-coupled receptor-like • Ras-like P-loop GTPases • Transducin (heterotrimeric G protein), gamma chain
SCOP2	Family Identifier	• G protein-coupled receptor-like • Ras-like P-loop GTPases • Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	V0S
PDB Residues	L:L:?1
Environment Details	Open EMBL-EBI Page
Code	V0S
Name	3-chloro-N-[trans-4-(methylamino)cyclohexyl]-N-{[3-(pyridin-4-yl)phenyl]methyl}-1-benzothiophene-2-carboxamide
Synonyms
Identifier
Formula	C28 H28 Cl N3 O S
Molecular Weight	490.059
SMILES
PubChem
Formal Charge	0
Total Atoms	62
Total Chiral Atoms	0
Total Bonds	66
Total Aromatic Bonds	22


Code	CLR
PDB Residues	W:W:?1
Environment Details	Open EMBL-EBI Page
Code	CLR
Name	Cholesterol
Synonyms	Cholesterin Cholesterol Cholest-5-en-3beta-ol (3β,14β,17α)-cholest-5-en-3-ol
Identifier
Formula	C27 H46 O
Molecular Weight	386.654
SMILES
PubChem	5997
Formal Charge	0
Total Atoms	74
Total Chiral Atoms	8
Total Bonds	77
Total Aromatic Bonds	0


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	Q99835
Sequence	>6XBL_nogp_Chain_R H C G R A A P C E P L R Y N V C L G S V L P Y G A T S T L L A G D S D S Q E E A H G K L V L W S G L R N A P R C W A V I Q P L L C A V Y M P K C E N D R V E L P S R T L C Q A T R G P C A I V E R E R G W P D F L R C T P D R F P E G C T N E V Q N I K F N S S G Q C E V P L V R T D N P K S W Y E D V E G C G I Q C Q N P L F T E A E H Q D M H S Y I A A F G A V T G L C T L F T L A T F V A D W R N S N R Y P A V I L F Y V N A C F F V G S I G W L A Q F M D G A R R E I V C R A D G T M R L G E P T S N E T L S C V I I F V I V Y Y A L M A G V V W F V V L T Y A W H T S F K A L G T T Y Q P L S G K T S Y F H L L T W S L P F V L T V A I L A V A Q V D G D S V S G I C F V G Y K N Y R Y R A G F V L A P I G L V L I V G G Y F L I R G V M T L F S I K S N H P G L L S E K A A S K I N E T M L R L G I F G F L A F G F V L I T F S C H F Y D F F N Q A E W E R S F R D Y V L C Q A N V T I G D C E I K N R P S L L V E K I N L F A M F G T G I A M S T W V W T Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	8CXO	F	Protein	Frizzled	SMO	Mus musculus	-	-	-	3.7	2022-08-03	10.1038/s41467-022-32125-2
	7ZI0	F	Protein	Frizzled	SMO	Homo sapiens	SAG	Cholesterol	-	3	2022-06-15	10.1126/sciadv.abm5563
	6XBM	F	Protein	Frizzled	SMO	Homo sapiens	-	25(S)-Epoxycholesterol	Gi1/β1/γ2	3.14	2020-09-30	10.1038/s41589-020-0646-2
	6XBM (No Gprot)	F	Protein	Frizzled	SMO	Homo sapiens	-	25(S)-Epoxycholesterol		3.14	2020-09-30	10.1038/s41589-020-0646-2
	6XBL	F	Protein	Frizzled	SMO	Homo sapiens	SAG	Cholesterol	Gi1/β1/γ2	3.96	2020-09-30	10.1038/s41589-020-0646-2
	6XBL (No Gprot)	F	Protein	Frizzled	SMO	Homo sapiens	SAG	Cholesterol		3.96	2020-09-30	10.1038/s41589-020-0646-2
	6XBK	F	Protein	Frizzled	SMO	Homo sapiens	-	Cholesterol	Gi1/β1/γ2	3.24	2020-09-30	10.1038/s41589-020-0646-2
	6XBK (No Gprot)	F	Protein	Frizzled	SMO	Homo sapiens	-	Cholesterol		3.24	2020-09-30	10.1038/s41589-020-0646-2
	6XBJ	F	Protein	Frizzled	SMO	Homo sapiens	-	Cholesterol	Gi1/β1/γ2	3.88	2020-09-30	10.1038/s41589-020-0646-2
	6XBJ (No Gprot)	F	Protein	Frizzled	SMO	Homo sapiens	-	Cholesterol		3.88	2020-09-30	10.1038/s41589-020-0646-2
	6O3C	F	Protein	Frizzled	SMO	Mus musculus	SAG21k	Cholesterol	-	2.8	2019-07-03	10.1038/s41586-019-1355-4
	6OT0	F	Protein	Frizzled	SMO	Homo sapiens	-	25(S)-Epoxycholesterol	Gi1/β1/γ2	3.84	2019-06-12	10.1038/s41586-019-1286-0
	6OT0 (No Gprot)	F	Protein	Frizzled	SMO	Homo sapiens	-	25(S)-Epoxycholesterol		3.84	2019-06-12	10.1038/s41586-019-1286-0
	6D35	F	Protein	Frizzled	SMO	Xenopus laevis	-	Cholesterol	-	3.9	2018-05-23	10.1016/j.cell.2018.04.029
	6D32	F	Protein	Frizzled	SMO	Xenopus laevis	Cyclopamine	Cyclopamine	-	3.75	2018-05-23	10.1016/j.cell.2018.04.029
	5V57	F	Protein	Frizzled	SMO	Homo sapiens	TC114	-	-	3	2017-05-24	10.1038/ncomms15383
	5V56	F	Protein	Frizzled	SMO	Homo sapiens	TC114	-	-	2.9	2017-05-24	10.1038/ncomms15383
	5L7I	F	Protein	Frizzled	SMO	Homo sapiens	Vismodegib	-	-	3.3	2016-07-20	10.1038/nature18934
	5L7D	F	Protein	Frizzled	SMO	Homo sapiens	-	Cholesterol	-	3.2	2016-07-20	10.1038/nature18934
	4QIN	F	Protein	Frizzled	SMO	Homo sapiens	SAG1.5	-	-	2.6	2014-07-23	10.1038/ncomms5355
	4QIM	F	Protein	Frizzled	SMO	Homo sapiens	ANTA XV	-	-	2.61	2014-07-23	10.1038/ncomms5355
	4O9R	F	Protein	Frizzled	SMO	Homo sapiens	Cyclopamine	-	-	3.2	2014-03-05	10.1038/ncomms4309
	4N4W	F	Protein	Frizzled	SMO	Homo sapiens	-	SANT-1	-	2.8	2014-01-22	10.1038/ncomms5355
	4JKV	F	Protein	Frizzled	SMO	Homo sapiens	Taladegib	-	-	2.45	2013-04-24	10.1038/nature12167
	4JKV (Multimeric)	F	Protein	Frizzled	SMO	Homo sapiens	Taladegib	-		2.45	2013-04-24	10.1038/nature12167

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