psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:H63	R:R:P175	4.58	No	No	0	3	5
2	R:R:C64	R:R:P175	5.65	No	No	0	7	5
3	R:R:C178	R:R:C64	7.28	No	No	0	6	7
4	R:R:G65	R:R:R138	6	No	No	0	4	4
5	R:R:L91	R:R:R66	7.29	No	No	0	5	6
6	R:R:L141	R:R:R66	10.93	No	No	0	7	6
7	R:R:R173	R:R:R66	4.26	No	No	0	4	6
8	R:R:A68	R:R:V139	3.39	No	No	0	5	7
9	R:R:C70	R:R:S89	3.44	No	No	0	9	8
10	R:R:C134	R:R:C70	5.46	No	No	0	9	9
11	R:R:E71	R:R:R74	3.49	No	No	5	7	4
12	R:R:E71	R:R:Q99	8.92	No	No	5	7	9
13	R:R:L73	R:R:N76	4.12	No	No	0	7	4
14	R:R:G86	R:R:L73	3.42	No	No	0	6	7
15	R:R:Q99	R:R:R74	15.19	No	No	5	9	4
16	R:R:H103	R:R:Y75	11.98	No	No	0	5	3
17	R:R:N76	R:R:V82	4.43	No	No	0	4	4
18	R:R:L83	R:R:N76	4.12	No	No	0	7	4
19	R:R:C78	R:R:S81	3.44	Yes	No	4	9	5
20	R:R:C127	R:R:C78	7.28	No	Yes	0	9	9
21	R:R:C78	R:R:I185	4.91	Yes	Yes	4	9	4
22	R:R:C78	R:R:F187	4.19	Yes	Yes	4	9	6
23	R:R:L106	R:R:L79	4.15	No	No	0	8	5
24	R:R:L79	R:R:R113	4.86	No	No	0	5	5
25	R:R:F187	R:R:S81	9.25	Yes	No	4	6	5
26	R:R:L83	R:R:Y85	14.07	No	Yes	0	7	9
27	R:R:P84	R:R:Y85	4.17	No	Yes	0	4	9
28	R:R:N184	R:R:P84	6.52	No	No	4	3	4
29	R:R:I185	R:R:P84	5.08	Yes	No	4	4	4
30	R:R:M131	R:R:Y85	3.59	Yes	Yes	0	5	9
31	R:R:K133	R:R:Y85	7.17	Yes	Yes	0	6	9
32	R:R:A87	R:R:C134	3.61	No	No	0	4	9
33	R:R:Q99	R:R:T88	12.76	No	No	0	9	9
34	R:R:M131	R:R:T88	4.52	Yes	No	0	5	9
35	R:R:L92	R:R:V129	4.47	No	No	0	8	7
36	R:R:L141	R:R:L92	4.15	No	No	0	7	8
37	R:R:L92	R:R:R173	3.64	No	No	0	8	4
38	R:R:A93	R:R:S96	3.42	No	No	0	5	6
39	R:R:D95	R:R:K105	4.15	Yes	Yes	2	5	4
40	R:R:D95	R:R:P164	6.44	Yes	No	2	5	9
41	R:R:D95	R:R:F166	3.58	Yes	Yes	2	5	6
42	R:R:H103	R:R:V107	6.92	No	No	0	5	4
43	R:R:K105	R:R:L108	7.05	Yes	No	2	4	5
44	R:R:K105	R:R:W109	8.12	Yes	Yes	2	4	7
45	R:R:K105	R:R:Y130	15.53	Yes	Yes	2	4	7
46	R:R:L108	R:R:W109	10.25	No	Yes	2	5	7
47	R:R:L126	R:R:W109	3.42	No	Yes	0	9	7
48	R:R:W109	R:R:Y130	6.75	Yes	Yes	2	7	7
49	R:R:V157	R:R:W109	6.13	No	Yes	0	6	7
50	R:R:R113	R:R:S110	5.27	No	No	0	5	5
51	R:R:G111	R:R:I496	3.53	No	No	0	5	4
52	R:R:L112	R:R:W119	3.42	No	Yes	0	8	9
53	R:R:R113	R:R:W119	13.99	No	Yes	0	5	9
54	R:R:L197	R:R:N114	8.24	No	No	0	9	5
55	R:R:A115	R:R:E211	6.03	No	Yes	0	6	5
56	R:R:G191	R:R:P116	4.06	No	No	0	5	9
57	R:R:R117	R:R:W206	20.99	No	Yes	0	5	4
58	R:R:E211	R:R:R117	9.3	Yes	No	0	5	5
59	R:R:G212	R:R:R117	6	No	No	0	7	5
60	R:R:C118	R:R:C154	7.28	No	No	0	9	9
61	R:R:C118	R:R:E211	7.6	No	Yes	0	9	5
62	R:R:Q123	R:R:W119	19.71	No	Yes	0	8	9
63	R:R:Q192	R:R:W119	4.38	No	Yes	0	4	9
64	R:R:A120	R:R:S190	3.42	No	No	0	4	6
65	R:R:T150	R:R:V121	4.76	Yes	No	0	7	7
66	R:R:I122	R:R:L125	5.71	No	Yes	0	7	7
67	R:R:I122	R:R:L126	9.99	No	No	0	7	9
68	R:R:I122	R:R:T150	7.6	No	Yes	0	7	7
69	R:R:F187	R:R:Q123	21.08	Yes	No	0	6	8
70	R:R:F187	R:R:P124	10.11	Yes	No	0	6	5
71	R:R:L125	R:R:L146	9.69	Yes	No	0	7	6
72	R:R:L125	R:R:R151	3.64	Yes	Yes	0	7	5
73	R:R:L125	R:R:L167	4.15	Yes	No	0	7	7
74	R:R:V129	R:R:Y130	3.79	No	Yes	2	7	7
75	R:R:F166	R:R:V129	3.93	Yes	No	2	6	7
76	R:R:M131	R:R:Y130	3.59	Yes	Yes	0	5	7
77	R:R:F166	R:R:Y130	9.28	Yes	Yes	2	6	7
78	R:R:E140	R:R:K133	5.4	No	Yes	6	5	6
79	R:R:E181	R:R:K133	5.4	No	Yes	6	5	6
80	R:R:E135	R:R:R138	3.49	No	No	0	6	4
81	R:R:E140	R:R:E181	16.49	No	No	6	5	5
82	R:R:L141	R:R:P175	8.21	No	No	0	7	5
83	R:R:F174	R:R:P142	14.45	No	No	0	8	8
84	R:R:S143	R:R:T145	4.8	No	No	0	8	6
85	R:R:Q148	R:R:R144	7.01	No	No	0	5	6
86	R:R:P171	R:R:R144	4.32	No	No	0	3	6
87	R:R:E176	R:R:R144	10.47	No	No	0	4	6
88	R:R:L146	R:R:N180	6.87	No	No	0	6	5
89	R:R:C147	R:R:R151	8.36	No	Yes	0	9	5
90	R:R:C147	R:R:C169	7.28	No	No	0	9	9
91	R:R:R151	R:R:T150	9.06	Yes	Yes	0	5	7
92	R:R:C154	R:R:T150	5.07	No	Yes	0	9	7
93	R:R:R151	R:R:W163	12	Yes	Yes	7	5	8
94	R:R:R151	R:R:R168	4.26	Yes	No	7	5	4
95	R:R:G152	R:R:P153	4.06	No	No	0	4	6
96	R:R:C154	R:R:P153	3.77	No	No	0	9	6
97	R:R:E211	R:R:I156	8.2	Yes	No	0	5	5
98	R:R:V157	R:R:W163	17.16	No	Yes	0	6	8
99	R:R:E158	R:R:W163	6.54	No	Yes	0	7	8
100	R:R:D209	R:R:R159	4.76	No	No	0	4	5
101	R:R:R159	R:R:R485	8.53	No	No	0	5	5
102	R:R:E160	R:R:R161	5.82	No	No	0	4	5
103	R:R:E160	R:R:L489	7.95	No	No	0	4	4
104	R:R:L167	R:R:W163	4.56	No	Yes	0	7	8
105	R:R:R168	R:R:W163	19.99	No	Yes	7	4	8
106	R:R:F166	R:R:P164	7.22	Yes	No	2	6	9
107	R:R:F166	R:R:L167	15.83	Yes	No	0	6	7
108	R:R:C169	R:R:F174	6.98	No	No	0	9	8
109	R:R:P171	R:R:T170	6.99	No	No	0	3	6
110	R:R:D172	R:R:T170	7.23	No	No	0	4	6
111	R:R:D172	R:R:R173	3.57	No	No	0	4	4
112	R:R:N180	R:R:V182	7.39	No	No	0	5	4
113	R:R:I185	R:R:V182	4.61	Yes	No	0	4	4
114	R:R:I185	R:R:N184	5.66	Yes	No	4	4	3
115	R:R:F187	R:R:I185	6.28	Yes	Yes	4	6	4
116	R:R:C193	R:R:R199	4.18	No	No	0	9	4
117	R:R:C193	R:R:C213	7.28	No	No	0	9	9
118	R:R:P196	R:R:V195	3.53	No	No	0	7	4
119	R:R:C213	R:R:L197	11.11	No	No	0	9	9
120	R:R:T200	R:R:W206	4.85	No	Yes	0	6	4
121	R:R:D298	R:R:T200	10.12	Yes	No	0	7	6
122	R:R:N202	R:R:P203	4.89	Yes	No	0	5	4
123	R:R:K204	R:R:N202	5.6	No	Yes	1	3	5
124	R:R:N202	R:R:S205	4.47	Yes	No	1	5	7
125	R:R:N202	R:R:R296	3.62	Yes	Yes	1	5	6
126	R:R:P203	R:R:W206	6.76	No	Yes	0	4	4
127	R:R:K204	R:R:S205	9.18	No	No	1	3	7
128	R:R:K204	R:R:T307	10.51	No	No	0	3	6
129	R:R:R296	R:R:S205	7.91	Yes	No	1	6	7
130	R:R:D209	R:R:Y207	22.99	No	Yes	1	4	7
131	R:R:V210	R:R:Y207	5.05	No	Yes	1	5	7
132	R:R:F484	R:R:Y207	6.19	Yes	Yes	1	6	7
133	R:R:V488	R:R:Y207	7.57	No	Yes	1	6	7
134	R:R:D209	R:R:V210	7.3	No	No	1	4	5
135	R:R:E211	R:R:V210	4.28	Yes	No	0	5	5
136	R:R:I215	R:R:Q216	5.49	No	No	0	5	7
137	R:R:I215	R:R:P220	5.08	No	No	0	5	8
138	R:R:I215	R:R:M301	7.29	No	No	0	5	4
139	R:R:C217	R:R:C295	7.28	No	No	0	9	9
140	R:R:E224	R:R:Q218	7.65	No	No	0	4	5
141	R:R:Q218	R:R:R291	3.5	No	No	0	5	5
142	R:R:N219	R:R:P220	6.52	Yes	No	0	7	8
143	R:R:L221	R:R:N219	5.49	No	Yes	0	6	7
144	R:R:F222	R:R:N219	8.46	Yes	Yes	0	6	7
145	R:R:N219	R:R:V386	4.43	Yes	No	0	7	5
146	L:L:?1	R:R:N219	12.94	Yes	Yes	0	0	7
147	R:R:F484	R:R:P220	4.33	Yes	No	0	6	8
148	R:R:L221	R:R:P513	6.57	No	No	0	6	8
149	R:R:E226	R:R:F222	9.33	No	Yes	0	8	6
150	R:R:F222	R:R:H227	4.53	Yes	No	0	6	7
151	R:R:F222	R:R:R512	7.48	Yes	No	0	6	6
152	R:R:F222	R:R:P513	8.67	Yes	No	0	6	8
153	R:R:F222	R:R:L515	3.65	Yes	No	0	6	5
154	R:R:E226	R:R:T223	8.47	No	No	0	8	5
155	R:R:E224	R:R:H227	14.77	No	No	0	4	7
156	R:R:D229	R:R:M230	4.16	No	No	8	6	7
157	R:R:D229	R:R:K519	4.15	No	Yes	8	6	7
158	R:R:L515	R:R:M230	12.72	No	No	0	5	7
159	R:R:K519	R:R:M230	8.64	Yes	No	8	7	7
160	R:R:H231	R:R:Q284	6.18	No	No	9	7	9
161	R:R:F285	R:R:H231	7.92	Yes	No	9	8	7
162	R:R:F237	R:R:Y233	15.47	No	No	0	4	6
163	R:R:K519	R:R:Y233	21.5	Yes	No	0	7	6
164	R:R:L522	R:R:Y233	3.52	No	No	0	7	6
165	R:R:I234	R:R:W281	7.05	No	Yes	0	7	7
166	R:R:F285	R:R:I234	3.77	Yes	No	0	8	7
167	R:R:A235	R:R:F285	4.16	No	Yes	0	5	8
168	R:R:F237	R:R:F523	5.36	No	No	0	4	6
169	R:R:F237	R:R:F526	11.79	No	No	0	4	9
170	R:R:G238	R:R:L282	3.42	No	No	0	7	7
171	R:R:F526	R:R:G238	4.52	No	No	0	9	7
172	R:R:F526	R:R:T241	5.19	No	No	0	9	7
173	R:R:G242	R:R:S278	3.71	No	No	0	4	8
174	R:R:C244	R:R:I530	4.91	No	No	0	6	7
175	R:R:C244	R:R:S533	3.44	No	No	0	6	9
176	R:R:F275	R:R:T245	3.89	No	No	0	5	8
177	R:R:F247	R:R:T251	5.19	No	No	10	8	9
178	R:R:F247	R:R:V536	5.24	No	Yes	10	8	8
179	R:R:N271	R:R:T248	11.7	No	No	0	9	8
180	R:R:S533	R:R:T248	4.8	No	No	0	9	8
181	R:R:T248	R:R:V536	7.93	No	Yes	0	8	8
182	R:R:F268	R:R:L249	3.65	No	No	0	8	6
183	R:R:F275	R:R:L249	4.87	No	No	0	5	6
184	R:R:T251	R:R:V536	4.76	No	Yes	10	9	8
185	R:R:F252	R:R:F268	8.57	No	No	0	9	8
186	R:R:F252	R:R:V536	3.93	No	Yes	0	9	8
187	R:R:N260	R:R:W256	6.78	No	No	0	7	7
188	R:R:R261	R:R:S259	10.54	No	No	0	7	8
189	R:R:A264	R:R:R261	5.53	No	No	0	9	7
190	R:R:I266	R:R:Y262	4.84	Yes	Yes	3	8	9
191	R:R:T357	R:R:Y262	9.99	No	Yes	3	6	9
192	R:R:F360	R:R:Y262	8.25	Yes	Yes	3	9	9
193	R:R:H361	R:R:Y262	5.44	Yes	Yes	3	9	9
194	R:R:V265	R:R:Y269	5.05	No	Yes	0	8	8
195	R:R:I266	R:R:W331	7.05	Yes	Yes	3	8	9
196	R:R:I266	R:R:L335	5.71	Yes	No	0	8	8
197	R:R:F360	R:R:I266	6.28	Yes	Yes	3	9	8
198	R:R:L267	R:R:W535	14.81	No	Yes	0	8	9
199	R:R:F268	R:R:Y269	5.16	No	Yes	0	8	8
200	R:R:W331	R:R:Y269	14.47	Yes	Yes	3	9	8
201	R:R:H361	R:R:Y269	5.44	Yes	Yes	3	9	8
202	R:R:M532	R:R:V270	4.56	No	No	0	8	8
203	R:R:C273	R:R:G328	3.92	No	No	0	9	8
204	R:R:F274	R:R:G529	4.52	No	No	0	9	9
205	R:R:F275	R:R:I279	6.28	No	No	0	5	5
206	R:R:G280	R:R:I320	3.53	No	No	0	7	5
207	R:R:V321	R:R:W281	4.9	No	Yes	0	8	7
208	R:R:I389	R:R:W281	5.87	No	Yes	0	9	7
209	R:R:L522	R:R:W281	4.56	No	Yes	0	7	7
210	R:R:M525	R:R:W281	9.31	No	Yes	1	5	7
211	R:R:W281	W:W:?1	4.54	Yes	Yes	1	7	0
212	R:R:F285	R:R:Q284	8.2	Yes	No	9	8	9
213	R:R:G388	R:R:Q284	4.93	No	No	0	9	9
214	R:R:D287	R:R:G288	3.35	No	No	0	5	6
215	R:R:R290	R:R:R291	19.19	No	No	0	9	5
216	R:R:D298	R:R:R296	8.34	Yes	Yes	0	7	6
217	R:R:R296	R:R:R302	9.6	Yes	Yes	1	6	6
218	R:R:E310	R:R:R296	4.65	No	Yes	0	8	6
219	R:R:A297	R:R:E310	4.53	No	No	0	5	8
220	R:R:D298	R:R:T300	10.12	Yes	No	0	7	7
221	R:R:L303	R:R:M301	4.24	No	No	0	3	4
222	L:L:?1	R:R:M301	5.71	Yes	No	0	0	4
223	R:R:E305	R:R:R302	13.96	Yes	Yes	1	7	6
224	R:R:C314	R:R:R302	4.18	Yes	Yes	1	9	6
225	R:R:E305	R:R:P306	7.86	Yes	Yes	0	7	5
226	R:R:C314	R:R:E305	6.08	Yes	Yes	1	9	7
227	R:R:E305	R:R:V381	4.28	Yes	No	1	7	8
228	R:R:P306	R:R:V315	10.6	Yes	No	0	5	7
229	R:R:N309	R:R:T307	5.85	No	No	0	6	6
230	R:R:L312	R:R:V315	4.47	No	No	0	7	7
231	R:R:C314	R:R:C390	7.28	Yes	No	0	9	9
232	R:R:I317	R:R:I389	4.42	No	No	0	7	9
233	R:R:F318	R:R:Y322	7.22	Yes	Yes	1	9	9
234	R:R:F318	R:R:V381	15.73	Yes	No	1	9	8
235	R:R:F318	R:R:F391	6.43	Yes	Yes	1	9	8
236	R:R:F318	R:R:V392	5.24	Yes	No	1	9	9
237	R:R:T372	R:R:V319	6.35	No	No	0	9	7
238	R:R:M326	R:R:Y322	5.99	No	Yes	0	8	9
239	R:R:L371	R:R:Y322	5.86	No	Yes	0	8	9
240	R:R:F391	R:R:Y322	4.13	Yes	Yes	1	8	9
241	R:R:W365	R:R:Y323	7.72	No	Yes	0	9	8
242	R:R:P368	R:R:Y323	6.95	No	Yes	0	9	8
243	R:R:F369	R:R:Y323	4.13	No	Yes	0	7	8
244	R:R:L325	R:R:M525	4.24	No	No	0	5	5
245	R:R:M326	R:R:P368	3.35	No	No	0	8	9
246	R:R:M326	R:R:P407	6.71	No	No	0	8	9
247	R:R:V329	R:R:V411	4.81	No	No	0	6	5
248	R:R:T364	R:R:V330	4.76	No	No	0	9	6
249	R:R:H361	R:R:W331	6.35	Yes	Yes	3	9	9
250	R:R:T364	R:R:W331	20.62	No	Yes	0	9	9
251	R:R:W331	R:R:W365	11.25	Yes	No	3	9	9
252	R:R:F332	R:R:T336	5.19	Yes	No	0	9	7
253	R:R:F332	R:R:F455	6.43	Yes	No	11	9	8
254	R:R:F332	R:R:M532	7.46	Yes	No	11	9	8
255	R:R:F360	R:R:V334	9.18	Yes	No	0	9	7
256	R:R:L335	R:R:W339	21.64	No	Yes	0	8	9
257	R:R:F418	R:R:Y337	11.35	No	No	0	8	7
258	R:R:W339	R:R:W535	10.31	Yes	Yes	0	9	9
259	R:R:H340	R:R:K344	5.24	No	No	0	7	6
260	R:R:H340	R:R:R421	4.51	No	No	0	7	7
261	R:R:G422	R:R:H340	4.77	No	No	0	8	7
262	R:R:P352	R:R:T341	10.49	No	No	0	7	6
263	R:R:F343	R:R:L426	15.83	No	No	0	9	9
264	R:R:F360	R:R:T357	3.89	Yes	No	3	9	6
265	R:R:H361	R:R:W365	10.58	Yes	No	3	9	9
266	R:R:F403	R:R:I375	6.28	No	No	0	8	7
267	R:R:K395	R:R:Q380	4.07	Yes	No	1	3	7
268	R:R:N396	R:R:Q380	11.88	No	No	1	7	7
269	R:R:V381	R:R:V392	4.81	No	No	1	8	9
270	R:R:D382	R:R:G383	3.35	No	No	0	9	8
271	R:R:D382	R:R:Y394	6.9	No	Yes	0	9	5
272	R:R:C390	R:R:G383	3.92	No	No	0	9	8
273	R:R:D384	R:R:V386	5.84	No	No	0	8	5
274	R:R:D384	R:R:S387	11.78	No	No	0	8	8
275	R:R:D384	R:R:Y394	16.09	No	Yes	0	8	5
276	R:R:I389	R:R:S387	4.64	No	No	0	9	8
277	R:R:F391	R:R:V392	3.93	Yes	No	1	8	9
278	R:R:F391	R:R:Y394	8.25	Yes	Yes	1	8	5
279	R:R:F391	W:W:?1	14.57	Yes	Yes	1	8	0
280	L:L:?1	R:R:Y394	8.68	Yes	Yes	1	0	5
281	R:R:Y394	W:W:?1	7.01	Yes	Yes	1	5	0
282	R:R:K395	R:R:N396	6.99	Yes	No	1	3	7
283	R:R:E481	R:R:K395	4.05	No	Yes	1	5	3
284	L:L:?1	R:R:K395	10.44	Yes	Yes	1	0	3
285	R:R:N396	R:R:Y399	4.65	No	No	0	7	5
286	R:R:R398	R:R:Y397	5.14	No	No	0	1	3
287	R:R:Q477	R:R:Y397	6.76	No	No	0	6	3
288	R:R:H470	R:R:R400	3.39	Yes	Yes	1	7	9
289	R:R:D473	R:R:R400	10.72	No	Yes	0	8	9
290	R:R:F474	R:R:R400	7.48	Yes	Yes	1	6	9
291	R:R:A401	R:R:F474	8.32	No	Yes	0	6	6
292	R:R:H470	R:R:V404	12.45	Yes	No	1	7	7
293	R:R:V404	W:W:?1	5.94	No	Yes	1	7	0
294	R:R:F467	R:R:L405	9.74	No	No	0	7	8
295	R:R:I408	R:R:V463	4.61	No	No	0	7	7
296	R:R:I408	W:W:?1	9.96	No	Yes	0	7	0
297	R:R:L412	R:R:V463	8.94	No	No	0	7	7
298	R:R:F418	R:R:Y417	5.16	No	No	0	8	5
299	R:R:R421	R:R:Y417	9.26	No	No	0	7	5
300	R:R:L419	R:R:L452	5.54	No	No	0	7	8
301	R:R:N432	R:R:S428	5.96	No	No	0	6	5
302	R:R:H433	R:R:P434	9.15	Yes	No	0	8	7
303	R:R:H433	R:R:L437	3.86	Yes	No	0	8	6
304	R:R:E439	R:R:S438	4.31	No	No	0	5	8
305	R:R:E439	R:R:K440	4.05	No	No	0	5	6
306	R:R:K440	R:R:K444	5.75	No	No	0	6	9
307	R:R:R451	R:R:W535	11	No	Yes	0	9	9
308	R:R:F455	R:R:M532	4.98	No	No	11	8	8
309	R:R:F455	R:R:W535	17.04	No	Yes	0	8	9
310	R:R:F462	R:R:G527	4.52	Yes	No	0	7	5
311	R:R:F462	R:R:T528	7.78	Yes	No	0	7	7
312	R:R:H470	R:R:T466	6.85	Yes	No	0	7	8
313	R:R:C469	R:R:V517	5.12	No	No	0	7	6
314	R:R:C469	R:R:N521	11.02	No	No	0	7	8
315	R:R:F474	R:R:H470	7.92	Yes	Yes	1	6	7
316	R:R:H470	W:W:?1	10.26	Yes	Yes	1	7	0
317	R:R:N476	R:R:Y472	8.14	No	No	0	6	7
318	R:R:V517	R:R:Y472	7.57	No	No	0	6	7
319	L:L:?1	R:R:D473	11.87	Yes	No	0	0	8
320	R:R:N476	R:R:W480	25.99	No	Yes	0	6	9
321	R:R:E481	R:R:Q477	6.37	No	No	0	5	6
322	R:R:E479	R:R:N511	6.57	No	Yes	0	2	4
323	R:R:N511	R:R:W480	11.3	Yes	Yes	0	4	9
324	R:R:P513	R:R:W480	14.86	No	Yes	0	8	9
325	L:L:?1	R:R:W480	3.83	Yes	Yes	0	0	9
326	L:L:?1	R:R:E481	8.92	Yes	No	1	0	5
327	R:R:N511	R:R:S483	5.96	Yes	No	0	4	7
328	R:R:F484	R:R:V488	6.55	Yes	No	1	6	6
329	L:L:?1	R:R:F484	13.94	Yes	Yes	1	0	6
330	R:R:Q491	R:R:Y487	23.67	No	No	0	4	4
331	R:R:I509	R:R:Y487	4.84	No	No	0	4	4
332	R:R:C490	R:R:C507	7.28	No	No	0	9	9
333	R:R:D506	R:R:Q491	10.44	No	No	0	3	4
334	R:R:I496	R:R:N493	8.5	No	No	0	4	5
335	R:R:I509	R:R:R512	6.26	No	No	0	4	6
336	R:R:K510	R:R:N511	5.6	No	Yes	0	4	4
337	R:R:E518	R:R:L515	3.98	No	No	0	7	5
338	R:R:K519	R:R:L516	5.64	Yes	No	0	7	4
339	R:R:E518	R:R:V517	7.13	No	No	0	7	6
340	L:L:?1	R:R:E518	8.92	Yes	No	0	0	7
341	R:R:N521	W:W:?1	5.48	No	Yes	0	8	0
342	R:R:M525	W:W:?1	18.33	No	Yes	1	5	0
343	R:R:T528	W:W:?1	19.11	No	Yes	0	7	0
344	R:R:T534	R:R:W535	6.06	No	Yes	0	7	9
345	R:R:G191	R:R:Q192	3.29	No	No	0	5	4
346	R:R:L353	R:R:P263	3.28	No	No	0	8	9
347	R:R:L376	R:R:P306	3.28	No	Yes	0	8	5
348	R:R:L353	R:R:P352	3.28	No	No	0	8	7
349	R:R:E158	R:R:G162	3.27	No	No	0	7	3
350	R:R:C314	R:R:I293	3.27	Yes	Yes	0	9	8
351	R:R:A283	R:R:I317	3.25	No	No	0	5	7
352	R:R:S89	R:R:V139	3.23	No	No	0	8	7
353	R:R:A102	R:R:M131	3.22	No	Yes	0	7	5
354	R:R:A289	R:R:M286	3.22	No	No	0	7	4
355	R:R:A87	R:R:K133	3.21	No	Yes	0	4	6
356	R:R:S278	R:R:T241	3.2	No	No	0	8	7
357	R:R:S313	R:R:T311	3.2	No	No	0	7	7
358	R:R:G435	R:R:H433	3.18	No	Yes	0	5	8
359	R:R:E194	R:R:P196	3.14	No	No	0	6	7
360	R:R:F403	R:R:Y399	3.09	No	No	0	8	5
361	R:R:I293	R:R:V294	3.07	Yes	No	0	8	8
362	R:R:K105	R:R:S96	3.06	Yes	No	0	4	6
363	R:R:C507	R:R:Q491	3.05	No	No	0	9	4
364	R:R:M449	R:R:V423	3.04	No	No	0	9	7
365	R:R:I429	R:R:T425	3.04	Yes	No	0	7	7
366	R:R:F274	R:R:G328	3.01	No	No	0	9	8
367	R:R:F460	R:R:G461	3.01	No	No	0	5	5
368	R:R:G191	R:R:R199	3	No	No	0	5	4
369	R:R:G393	R:R:R400	3	No	Yes	0	9	9
370	R:R:L410	R:R:V411	2.98	No	No	0	4	5
371	R:R:L419	R:R:T336	2.95	No	No	0	7	7
372	R:R:I317	R:R:I320	2.94	No	No	0	7	5
373	R:R:I465	R:R:I520	2.94	Yes	No	0	5	5
374	R:R:Q123	R:R:S190	2.89	No	No	0	8	6
375	R:R:E101	R:R:S98	2.87	No	No	0	5	6
376	R:R:I445	R:R:L346	2.85	No	No	0	9	6
377	R:R:L426	R:R:M449	2.83	No	No	0	9	9
378	R:R:C295	R:R:R291	2.79	No	No	0	9	5
379	R:R:P352	R:R:Y350	2.78	No	No	0	7	7
380	R:R:L363	R:R:L367	2.77	No	Yes	0	4	5
381	R:R:P263	R:R:W339	2.7	No	Yes	0	9	9
382	R:R:A327	R:R:Y323	2.67	No	Yes	0	9	8
383	R:R:A345	R:R:Y350	2.67	No	No	0	7	7
384	R:R:L353	R:R:Q351	2.66	No	No	0	8	7
385	R:R:R302	R:R:S313	2.64	Yes	No	0	6	7
386	R:R:E194	R:R:N114	2.63	No	No	0	6	5
387	R:R:F274	R:R:V270	2.62	No	No	0	9	8
388	R:R:F332	R:R:V411	2.62	Yes	No	0	9	5
389	R:R:F369	R:R:V373	2.62	No	No	0	7	7
390	R:R:T372	R:R:Y322	2.5	No	Yes	0	9	9
391	R:R:V253	R:R:W256	2.45	No	No	0	5	7
392	R:R:V265	R:R:W256	2.45	No	No	0	8	7
393	R:R:F343	R:R:L346	2.44	No	No	0	9	6
394	R:R:F474	R:R:L405	2.44	Yes	No	0	6	8
395	R:R:N493	R:R:R161	2.41	No	No	0	5	5
396	R:R:E100	R:R:R74	2.33	No	No	0	4	4
397	R:R:G415	R:R:G416	2.11	Yes	No	0	8	5
398	R:R:F247	R:R:W537	2	No	No	0	8	8
399	R:R:F343	R:R:W339	2	No	Yes	0	9	9
400	R:R:C213	R:R:G214	1.96	No	No	0	9	8
401	R:R:A324	R:R:G277	1.95	No	No	0	7	6
402	R:R:A401	R:R:G402	1.95	No	No	0	6	5
403	R:R:A459	R:R:G456	1.95	No	No	0	7	7
404	R:R:A68	R:R:P69	1.87	No	No	0	5	4
405	R:R:A379	R:R:P306	1.87	No	Yes	0	6	5
406	R:R:A406	R:R:P407	1.87	No	No	0	5	9
407	R:R:G80	R:R:S81	1.86	No	No	0	5	5
408	R:R:G80	R:R:S189	1.86	No	No	0	5	5
409	R:R:G104	R:R:V107	1.84	No	No	0	4	4
410	R:R:G415	R:R:V333	1.84	Yes	No	0	8	9
411	R:R:G415	R:R:V414	1.84	Yes	No	0	8	5
412	R:R:G415	R:R:T336	1.82	Yes	No	0	8	7
413	R:R:G422	R:R:T425	1.82	No	No	0	8	7
414	R:R:P132	R:R:S89	1.78	No	No	0	9	8
415	R:R:G456	R:R:L419	1.71	No	No	0	7	7
416	R:R:A149	R:R:V121	1.7	No	No	0	4	7
417	R:R:A128	R:R:V182	1.7	No	No	0	8	4
418	R:R:A324	R:R:V276	1.7	No	No	0	7	5
419	R:R:A93	R:R:T90	1.68	No	No	0	5	5
420	R:R:D95	R:R:G94	1.68	Yes	No	0	5	5
421	R:R:A225	R:R:T223	1.68	No	No	0	4	5
422	R:R:D298	R:R:G299	1.68	Yes	No	0	7	4
423	R:R:G304	R:R:Q380	1.64	No	No	0	5	7
424	R:R:L367	R:R:P368	1.64	Yes	No	0	5	9
425	R:R:A338	R:R:I266	1.62	No	Yes	0	8	8
426	R:R:A289	R:R:I293	1.62	No	Yes	0	7	8
427	R:R:S385	R:R:V386	1.62	No	No	0	7	5
428	R:R:A524	R:R:I465	1.62	No	Yes	0	7	5
429	R:R:S358	R:R:T357	1.6	No	No	0	6	6
430	R:R:T200	R:R:V198	1.59	No	No	0	6	6
431	R:R:T495	R:R:V494	1.59	No	No	0	4	5
432	R:R:A272	R:R:L249	1.58	No	No	0	4	6
433	R:R:E71	R:R:P72	1.57	No	No	0	7	4
434	R:R:A67	R:R:D137	1.54	No	No	0	1	4
435	R:R:A254	R:R:D255	1.54	No	No	0	8	8
436	R:R:I316	R:R:V319	1.54	No	No	0	5	7
437	R:R:I420	R:R:V423	1.54	No	No	0	5	7
438	R:R:I445	R:R:T448	1.52	No	No	0	9	8
439	R:R:A155	R:R:E158	1.51	No	No	0	5	7
440	R:R:L367	R:R:S366	1.5	Yes	No	0	5	7
441	R:R:L106	R:R:V107	1.49	No	No	0	8	4
442	R:R:L367	R:R:V370	1.49	Yes	No	0	5	5
443	R:R:D229	R:R:S232	1.47	No	No	0	6	4
444	R:R:I429	R:R:I445	1.47	Yes	No	0	7	9
445	R:R:I420	R:R:M424	1.46	No	No	0	5	5
446	R:R:D506	R:R:V494	1.46	No	No	0	3	5
447	R:R:E100	R:R:S98	1.44	No	No	0	4	6
448	R:R:Q351	R:R:S354	1.44	No	No	0	7	7
449	R:R:I454	R:R:L450	1.43	No	No	0	6	6
450	R:R:I429	R:R:N432	1.42	Yes	No	0	7	6
451	R:R:K430	R:R:N446	1.4	No	No	0	8	7
452	R:R:M449	R:R:N446	1.4	No	No	0	9	7
453	R:R:A264	R:R:F252	1.39	No	No	0	9	9
454	R:R:D287	R:R:M286	1.39	No	No	0	5	4
455	R:R:A531	R:R:F462	1.39	No	Yes	0	6	7
456	R:R:E292	R:R:I293	1.37	No	Yes	0	5	8
457	R:R:E135	R:R:K133	1.35	No	Yes	0	6	6
458	R:R:E508	R:R:K510	1.35	No	No	0	4	4
459	R:R:D165	R:R:D95	1.33	No	Yes	0	4	5
460	R:R:E208	R:R:L303	1.33	No	No	0	4	3
461	R:R:H433	R:R:I429	1.33	Yes	Yes	0	8	7
462	R:R:D97	R:R:E101	1.3	No	No	0	3	5
463	R:R:S514	R:R:Y472	1.27	No	No	0	7	7
464	R:R:F462	R:R:I465	1.26	Yes	Yes	0	7	5
465	R:R:F523	R:R:I465	1.26	No	Yes	0	6	5
466	R:R:T348	R:R:Y350	1.25	No	No	0	7	7
467	R:R:F460	R:R:L412	1.22	No	No	0	5	7
468	R:R:D486	R:R:R482	1.19	No	No	0	4	3
469	R:R:E160	R:R:R485	1.16	No	No	0	4	5
470	R:R:D201	R:R:W206	1.12	No	Yes	0	5	4
471	R:R:F471	R:R:F474	1.07	No	Yes	0	4	6

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	R:R:C78	4.955	4	4	9
2	R:R:Y85	7.25	4	0	9
3	R:R:D95	3.436	5	2	5
4	R:R:K105	7.582	5	2	4
5	R:R:W109	6.934	5	2	7
6	R:R:W119	10.375	4	0	9
7	R:R:L125	5.7975	4	0	7
8	R:R:Y130	7.788	5	2	7
9	R:R:M131	3.73	4	0	5
10	R:R:K133	4.506	5	6	6
11	R:R:T150	6.6225	4	0	7
12	R:R:R151	7.464	5	7	5
13	R:R:W163	12.05	5	7	8
14	R:R:F166	7.968	5	2	6
15	R:R:I185	5.308	5	4	4
16	R:R:F187	10.182	5	4	6
17	R:R:N202	4.645	4	1	5
18	R:R:W206	8.43	4	0	4
19	R:R:Y207	10.45	4	1	7
20	R:R:E211	7.082	5	0	5
21	R:R:N219	7.568	5	0	7
22	R:R:F222	7.02	6	0	6
23	R:R:Y262	7.13	4	3	9
24	R:R:I266	5.1	5	3	8
25	R:R:Y269	7.53	4	3	8
26	R:R:W281	6.03833	6	1	7
27	R:R:F285	6.0125	4	9	8
28	R:R:I293	2.3325	4	0	8
29	R:R:R296	6.824	5	1	6
30	R:R:D298	7.565	4	0	7
31	R:R:R302	7.595	4	1	6
32	R:R:E305	8.045	4	1	7
33	R:R:P306	5.9025	4	0	5
34	R:R:C314	5.2025	4	1	9
35	R:R:F318	8.655	4	1	9
36	R:R:Y322	5.14	5	1	9
37	R:R:Y323	5.3675	4	0	8
38	R:R:W331	11.948	5	3	9
39	R:R:F332	5.425	4	11	9
40	R:R:W339	9.1625	4	0	9
41	R:R:F360	6.9	4	3	9
42	R:R:H361	6.9525	4	3	9
43	R:R:L367	1.85	4	0	5
44	R:R:F391	7.462	5	1	8
45	R:R:Y394	9.386	5	1	5
46	R:R:K395	6.3875	4	1	3
47	R:R:R400	6.1475	4	1	9
48	R:R:G415	1.9025	4	0	8
49	R:R:I429	1.815	4	0	7
50	R:R:H433	4.38	4	0	8
51	R:R:F462	3.7375	4	0	7
52	R:R:I465	1.77	4	0	5
53	R:R:H470	8.174	5	1	7
54	R:R:F474	5.446	5	1	6
55	R:R:W480	13.995	4	0	9
56	R:R:F484	7.7525	4	1	6
57	R:R:N511	7.3575	4	0	4
58	R:R:K519	9.9825	4	8	7
59	R:R:W535	11.844	5	0	9
60	R:R:V536	5.465	4	10	8
61	L:L:?1	9.47222	9	1	0
62	W:W:?1	10.5778	9	1	0

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:M131	R:R:Y85	12.748	3.59	Yes	Yes	0	5	9
2	R:R:M131	R:R:Y130	17.5047	3.59	Yes	Yes	0	5	7
3	R:R:L92	R:R:V129	31.1763	4.47	No	No	0	8	7
4	R:R:L141	R:R:L92	12.8832	4.15	No	No	0	7	8
5	R:R:L92	R:R:R173	16.5534	3.64	No	No	0	8	4
6	R:R:Q123	R:R:W119	21.3079	19.71	No	Yes	0	8	9
7	R:R:F187	R:R:Q123	24.1321	21.08	Yes	No	0	6	8
8	R:R:F187	R:R:I185	28.7281	6.28	Yes	Yes	4	6	4
9	R:R:F166	R:R:V129	23.6497	3.93	Yes	No	2	6	7
10	R:R:W109	R:R:Y130	22.6485	6.75	Yes	Yes	2	7	7
11	R:R:L126	R:R:W109	25.8807	3.42	No	Yes	0	9	7
12	R:R:E211	R:R:V210	87.0857	4.28	Yes	No	0	5	5
13	R:R:C118	R:R:E211	100	7.6	No	Yes	0	9	5
14	R:R:C118	R:R:C154	99.8425	7.28	No	No	0	9	9
15	R:R:C154	R:R:T150	99.3569	5.07	No	Yes	0	9	7
16	R:R:I122	R:R:T150	55.2175	7.6	No	Yes	0	7	7
17	R:R:I122	R:R:L125	28.8345	5.71	No	Yes	0	7	7
18	R:R:L125	R:R:L167	21.3201	4.15	Yes	No	0	7	7
19	R:R:F166	R:R:L167	30.7628	15.83	Yes	No	0	6	7
20	R:R:R151	R:R:T150	43.6682	9.06	Yes	Yes	0	5	7
21	R:R:L125	R:R:R151	29.4754	3.64	Yes	Yes	0	7	5
22	R:R:R151	R:R:W163	13.1604	12	Yes	Yes	7	5	8
23	R:R:L167	R:R:W163	11.1036	4.56	No	Yes	0	7	8
24	R:R:I122	R:R:L126	26.2543	9.99	No	No	0	7	9
25	R:R:Q192	R:R:W119	11.7611	4.38	No	Yes	0	4	9
26	R:R:G191	R:R:Q192	10.7931	3.29	No	No	0	5	4
27	R:R:E211	R:R:R117	18.1578	9.3	Yes	No	0	5	5
28	R:R:R117	R:R:W206	17.0668	20.99	No	Yes	0	5	4
29	R:R:L125	R:R:L146	36.9266	9.69	Yes	No	0	7	6
30	R:R:D172	R:R:R173	11.0958	3.57	No	No	0	4	4
31	R:R:L146	R:R:N180	36.0617	6.87	No	No	0	6	5
32	R:R:I185	R:R:V182	33.6135	4.61	Yes	No	0	4	4
33	R:R:N180	R:R:V182	35.219	7.39	No	No	0	5	4
34	R:R:V210	R:R:Y207	84.4456	5.05	No	Yes	1	5	7
35	R:R:F484	R:R:Y207	87.4694	6.19	Yes	Yes	1	6	7
36	L:L:?1	R:R:F484	80.1779	13.94	Yes	Yes	1	0	6
37	R:R:F222	R:R:N219	18.3907	8.46	Yes	Yes	0	6	7
38	L:L:?1	R:R:N219	14.1628	12.94	Yes	Yes	0	0	7
39	R:R:W281	W:W:?1	14.3801	4.54	Yes	Yes	1	7	0
40	R:R:Y394	W:W:?1	14.8979	7.01	Yes	Yes	1	5	0
41	L:L:?1	R:R:Y394	73.4241	8.68	Yes	Yes	1	0	5
42	R:R:F252	R:R:F268	14.0242	8.57	No	No	0	9	8
43	R:R:F268	R:R:Y269	20.371	5.16	No	Yes	0	8	8
44	R:R:W331	R:R:Y269	13.6239	14.47	Yes	Yes	3	9	8
45	R:R:W331	R:R:W365	45.2781	11.25	Yes	No	3	9	9
46	R:R:W365	R:R:Y323	60.4034	7.72	No	Yes	0	9	8
47	R:R:P368	R:R:Y323	61.8049	6.95	No	Yes	0	9	8
48	R:R:M326	R:R:P368	63.5069	3.35	No	No	0	8	9
49	R:R:M326	R:R:Y322	64.5015	5.99	No	Yes	0	8	9
50	R:R:F391	R:R:Y322	59.5951	4.13	Yes	Yes	1	8	9
51	R:R:F391	R:R:Y394	55.5102	8.25	Yes	Yes	1	8	5
52	R:R:H361	R:R:Y269	11.974	5.44	Yes	Yes	3	9	8
53	R:R:H361	R:R:W365	14.7682	10.58	Yes	No	3	9	9
54	R:R:I266	R:R:W331	34.0182	7.05	Yes	Yes	3	8	9
55	R:R:I266	R:R:L335	32.5867	5.71	Yes	No	0	8	8
56	R:R:L335	R:R:W339	32.1188	21.64	No	Yes	0	8	9
57	R:R:W339	R:R:W535	13.7936	10.31	Yes	Yes	0	9	9
58	R:R:F455	R:R:W535	11.5848	17.04	No	Yes	0	8	9
59	R:R:R296	R:R:R302	19.2511	9.6	Yes	Yes	1	6	6
60	R:R:E305	R:R:R302	12.728	13.96	Yes	Yes	1	7	6
61	R:R:E305	R:R:V381	14.4821	4.28	Yes	No	1	7	8
62	R:R:F318	R:R:V381	10.5525	15.73	Yes	No	1	9	8
63	R:R:F343	R:R:L346	10.4771	2.44	No	No	0	9	6
64	R:R:F343	R:R:W339	14.9035	2	No	Yes	0	9	9
65	R:R:F391	W:W:?1	13.5485	14.57	Yes	Yes	1	8	0

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:F484	R:R:Y207	6.19	1	Yes	Yes	6	7	1	2
R:R:V488	R:R:Y207	7.57	1	No	Yes	6	7	2	2
R:R:I215	R:R:P220	5.08	0	No	No	5	8	2	2
R:R:I215	R:R:M301	7.29	0	No	No	5	4	2	1
R:R:N219	R:R:P220	6.52	0	Yes	No	7	8	1	2
R:R:L221	R:R:N219	5.49	0	No	Yes	6	7	2	1
R:R:F222	R:R:N219	8.46	0	Yes	Yes	6	7	2	1
R:R:N219	R:R:V386	4.43	0	Yes	No	7	5	1	2
L:L:?1	R:R:N219	12.94	1	Yes	Yes	0	7	0	1
R:R:F484	R:R:P220	4.33	1	Yes	No	6	8	1	2
R:R:L221	R:R:P513	6.57	0	No	No	6	8	2	2
R:R:F222	R:R:P513	8.67	0	Yes	No	6	8	2	2
R:R:F222	R:R:L515	3.65	0	Yes	No	6	5	2	2
R:R:L303	R:R:M301	4.24	0	No	No	3	4	2	1
L:L:?1	R:R:M301	5.71	1	Yes	No	0	4	0	1
R:R:K395	R:R:Q380	4.07	1	Yes	No	3	7	1	2
R:R:N396	R:R:Q380	11.88	1	No	No	7	7	2	2
R:R:D382	R:R:Y394	6.9	0	No	Yes	9	5	2	1
R:R:D384	R:R:V386	5.84	0	No	No	8	5	2	2
R:R:D384	R:R:Y394	16.09	0	No	Yes	8	5	2	1
R:R:F391	R:R:Y394	8.25	1	Yes	Yes	8	5	2	1
R:R:F391	W:W:?1	14.57	1	Yes	Yes	8	0	2	2
L:L:?1	R:R:Y394	8.68	1	Yes	Yes	0	5	0	1
R:R:Y394	W:W:?1	7.01	1	Yes	Yes	5	0	1	2
R:R:K395	R:R:N396	6.99	1	Yes	No	3	7	1	2
R:R:E481	R:R:K395	4.05	1	No	Yes	5	3	1	1
L:L:?1	R:R:K395	10.44	1	Yes	Yes	0	3	0	1
R:R:D473	R:R:R400	10.72	0	No	Yes	8	9	1	2
L:L:?1	R:R:D473	11.87	1	Yes	No	0	8	0	1
R:R:N476	R:R:W480	25.99	0	No	Yes	6	9	2	1
R:R:E481	R:R:Q477	6.37	1	No	No	5	6	1	2
R:R:N511	R:R:W480	11.3	0	Yes	Yes	4	9	2	1
R:R:P513	R:R:W480	14.86	0	No	Yes	8	9	2	1
L:L:?1	R:R:W480	3.83	1	Yes	Yes	0	9	0	1
L:L:?1	R:R:E481	8.92	1	Yes	No	0	5	0	1
R:R:F484	R:R:V488	6.55	1	Yes	No	6	6	1	2
L:L:?1	R:R:F484	13.94	1	Yes	Yes	0	6	0	1
R:R:E518	R:R:L515	3.98	0	No	No	7	5	1	2
R:R:E518	R:R:V517	7.13	0	No	No	7	6	1	2
L:L:?1	R:R:E518	8.92	1	Yes	No	0	7	0	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:I234	R:R:W281	7.05	0	No	Yes	7	7	2	1
R:R:V321	R:R:W281	4.9	0	No	Yes	8	7	2	1
R:R:I389	R:R:W281	5.87	0	No	Yes	9	7	2	1
R:R:L522	R:R:W281	4.56	0	No	Yes	7	7	2	1
R:R:M525	R:R:W281	9.31	1	No	Yes	5	7	1	1
R:R:W281	W:W:?1	4.54	1	Yes	Yes	7	0	1	0
R:R:F318	R:R:Y322	7.22	1	Yes	Yes	9	9	2	2
R:R:F318	R:R:F391	6.43	1	Yes	Yes	9	8	2	1
R:R:F318	R:R:V392	5.24	1	Yes	No	9	9	2	2
R:R:F391	R:R:Y322	4.13	1	Yes	Yes	8	9	1	2
R:R:L325	R:R:M525	4.24	0	No	No	5	5	2	1
R:R:D382	R:R:Y394	6.9	0	No	Yes	9	5	2	1
R:R:D384	R:R:Y394	16.09	0	No	Yes	8	5	2	1
R:R:F391	R:R:V392	3.93	1	Yes	No	8	9	1	2
R:R:F391	R:R:Y394	8.25	1	Yes	Yes	8	5	1	1
R:R:F391	W:W:?1	14.57	1	Yes	Yes	8	0	1	0
L:L:?1	R:R:Y394	8.68	1	Yes	Yes	0	5	2	1
R:R:Y394	W:W:?1	7.01	1	Yes	Yes	5	0	1	0
R:R:H470	R:R:R400	3.39	1	Yes	Yes	7	9	1	2
R:R:F474	R:R:R400	7.48	1	Yes	Yes	6	9	2	2
R:R:H470	R:R:V404	12.45	1	Yes	No	7	7	1	1
R:R:V404	W:W:?1	5.94	1	No	Yes	7	0	1	0
R:R:I408	R:R:V463	4.61	0	No	No	7	7	1	2
R:R:I408	W:W:?1	9.96	0	No	Yes	7	0	1	0
R:R:F462	R:R:T528	7.78	0	Yes	No	7	7	2	1
R:R:H470	R:R:T466	6.85	1	Yes	No	7	8	1	2
R:R:C469	R:R:N521	11.02	0	No	No	7	8	2	1
R:R:F474	R:R:H470	7.92	1	Yes	Yes	6	7	2	1
R:R:H470	W:W:?1	10.26	1	Yes	Yes	7	0	1	0
R:R:N521	W:W:?1	5.48	0	No	Yes	8	0	1	0
R:R:M525	W:W:?1	18.33	1	No	Yes	5	0	1	0
R:R:T528	W:W:?1	19.11	0	No	Yes	7	0	1	0

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	6XBL_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	3.35
Number of Linked Nodes	424
Number of Links	471
Number of Hubs	62
Number of Links mediated by Hubs	230
Number of Communities	11
Number of Nodes involved in Communities	73
Number of Links involved in Communities	96

Path Summary
Number Of Nodes in MetaPath	66
Number Of Links MetaPath	65
Number of Shortest Paths	156636
Length Of Smallest Path	3
Average Path Length	18.8752
Length of Longest Path	49
Minimum Path Strength	1.26
Average Path Strength	7.2894
Maximum Path Strength	20.425
Minimum Path Correlation	0.7
Average Path Correlation	0.963303
Maximum Path Correlation	1
Minimum % Of Corr. Nodes	3.125
Average % Of Corr. Nodes	58.8556
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	47.8185
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process
Gene Ontology	Cellular Component
SCOP2	Domain Identifier	• Transducin (heterotrimeric G protein), gamma chain • Ras-like P-loop GTPases • G protein-coupled receptor-like
SCOP2	Family Identifier	• Transducin (heterotrimeric G protein), gamma chain • Ras-like P-loop GTPases • G protein-coupled receptor-like
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	V0S
PDB Residues	L:L:?1
Environment Details	Open EMBL-EBI Page
Code	V0S
Name	3-chloro-N-[trans-4-(methylamino)cyclohexyl]-N-{[3-(pyridin-4-yl)phenyl]methyl}-1-benzothiophene-2-carboxamide
Synonyms
Identifier
Formula	C28 H28 Cl N3 O S
Molecular Weight	490.059
SMILES
PubChem
Formal Charge	0
Total Atoms	62
Total Chiral Atoms	0
Total Bonds	66
Total Aromatic Bonds	22


Code	CLR
PDB Residues	W:W:?1
Environment Details	Open EMBL-EBI Page
Code	CLR
Name	Cholesterol
Synonyms	Cholesterin Cholesterol Cholest-5-en-3beta-ol (3β,14β,17α)-cholest-5-en-3-ol
Identifier
Formula	C27 H46 O
Molecular Weight	386.654
SMILES
PubChem	5997
Formal Charge	0
Total Atoms	74
Total Chiral Atoms	8
Total Bonds	77
Total Aromatic Bonds	0


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	Q99835
Sequence	>6XBL_nogp_Chain_R H C G R A A P C E P L R Y N V C L G S V L P Y G A T S T L L A G D S D S Q E E A H G K L V L W S G L R N A P R C W A V I Q P L L C A V Y M P K C E N D R V E L P S R T L C Q A T R G P C A I V E R E R G W P D F L R C T P D R F P E G C T N E V Q N I K F N S S G Q C E V P L V R T D N P K S W Y E D V E G C G I Q C Q N P L F T E A E H Q D M H S Y I A A F G A V T G L C T L F T L A T F V A D W R N S N R Y P A V I L F Y V N A C F F V G S I G W L A Q F M D G A R R E I V C R A D G T M R L G E P T S N E T L S C V I I F V I V Y Y A L M A G V V W F V V L T Y A W H T S F K A L G T T Y Q P L S G K T S Y F H L L T W S L P F V L T V A I L A V A Q V D G D S V S G I C F V G Y K N Y R Y R A G F V L A P I G L V L I V G G Y F L I R G V M T L F S I K S N H P G L L S E K A A S K I N E T M L R L G I F G F L A F G F V L I T F S C H F Y D F F N Q A E W E R S F R D Y V L C Q A N V T I G D C E I K N R P S L L V E K I N L F A M F G T G I A M S T W V W T Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	4JKV	F	Protein	Frizzled	SMO	Homo sapiens	Taladegib	-	-	2.45	2013-04-24	doi.org/10.1038/nature12167
	4N4W	F	Protein	Frizzled	SMO	Homo sapiens	-	SANT-1	-	2.8	2014-01-22	doi.org/10.1038/ncomms5355
	4O9R	F	Protein	Frizzled	SMO	Homo sapiens	Cyclopamine	-	-	3.2	2014-03-05	doi.org/10.1038/ncomms4309
	4QIM	F	Protein	Frizzled	SMO	Homo sapiens	ANTA XV	-	-	2.61	2014-07-23	doi.org/10.1038/ncomms5355
	4QIN	F	Protein	Frizzled	SMO	Homo sapiens	SAG1.5	-	-	2.6	2014-07-23	doi.org/10.1038/ncomms5355
	5L7D	F	Protein	Frizzled	SMO	Homo sapiens	-	Cholesterol	-	3.2	2016-07-20	doi.org/10.1038/nature18934
	5L7I	F	Protein	Frizzled	SMO	Homo sapiens	Vismodegib	-	-	3.3	2016-07-20	doi.org/10.1038/nature18934
	5V56	F	Protein	Frizzled	SMO	Homo sapiens	TC114	-	-	2.9	2017-05-24	doi.org/10.1038/ncomms15383
	5V57	F	Protein	Frizzled	SMO	Homo sapiens	TC114	-	-	3	2017-05-24	doi.org/10.1038/ncomms15383
	6D32	F	Protein	Frizzled	SMO	Xenopus laevis	Cyclopamine	Cyclopamine	-	3.75	2018-05-23	doi.org/10.1016/j.cell.2018.04.029
	6D35	F	Protein	Frizzled	SMO	Xenopus laevis	-	Cholesterol	-	3.9	2018-05-23	doi.org/10.1016/j.cell.2018.04.029
	6OT0	F	Protein	Frizzled	SMO	Homo sapiens	-	25(S)-Epoxycholesterol	Gi1/β1/γ2	3.84	2019-06-12	doi.org/10.1038/s41586-019-1286-0
	6OT0 (No Gprot)	F	Protein	Frizzled	SMO	Homo sapiens	-	25(S)-Epoxycholesterol		3.84	2019-06-12	doi.org/10.1038/s41586-019-1286-0
	6O3C	F	Protein	Frizzled	SMO	Mus musculus	SAG21k	Cholesterol	-	2.8	2019-07-03	doi.org/10.1038/s41586-019-1355-4
	6XBJ	F	Protein	Frizzled	SMO	Homo sapiens	-	Cholesterol	Gi1/β1/γ2	3.88	2020-09-30	doi.org/10.1038/s41589-020-0646-2
	6XBJ (No Gprot)	F	Protein	Frizzled	SMO	Homo sapiens	-	Cholesterol		3.88	2020-09-30	doi.org/10.1038/s41589-020-0646-2
	6XBK	F	Protein	Frizzled	SMO	Homo sapiens	-	Cholesterol	Gi1/β1/γ2	3.24	2020-09-30	doi.org/10.1038/s41589-020-0646-2
	6XBK (No Gprot)	F	Protein	Frizzled	SMO	Homo sapiens	-	Cholesterol		3.24	2020-09-30	doi.org/10.1038/s41589-020-0646-2
	6XBL	F	Protein	Frizzled	SMO	Homo sapiens	SAG	Cholesterol	Gi1/β1/γ2	3.96	2020-09-30	doi.org/10.1038/s41589-020-0646-2
	6XBL (No Gprot)	F	Protein	Frizzled	SMO	Homo sapiens	SAG	Cholesterol		3.96	2020-09-30	doi.org/10.1038/s41589-020-0646-2
	6XBM	F	Protein	Frizzled	SMO	Homo sapiens	-	25(S)-Epoxycholesterol	Gi1/β1/γ2	3.14	2020-09-30	doi.org/10.1038/s41589-020-0646-2
	6XBM (No Gprot)	F	Protein	Frizzled	SMO	Homo sapiens	-	25(S)-Epoxycholesterol		3.14	2020-09-30	doi.org/10.1038/s41589-020-0646-2
	7ZI0	F	Protein	Frizzled	SMO	Homo sapiens	SAG	Cholesterol	-	3	2022-06-15	doi.org/10.1126/sciadv.abm5563
	8CXO	F	Protein	Frizzled	SMO	Mus musculus	-	-	-	3.7	2022-08-03	doi.org/10.1038/s41467-022-32125-2

You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download 6XBL_nogp.zip

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You can also read or download a guide explaining the meaning of all files and numerical data.