psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:N192	12.11	Yes	Yes	2	0	7
2	L:L:?1	R:R:L194	5.55	Yes	Yes	2	0	6
3	L:L:?1	R:R:F195	2.93	Yes	Yes	2	0	6
4	L:L:?1	R:R:D357	16.33	Yes	Yes	2	0	8
5	L:L:?1	R:R:Y367	15.04	Yes	Yes	2	0	5
6	L:L:?1	R:R:K368	4.52	Yes	No	0	0	4
7	L:L:?1	R:R:R373	4.87	Yes	Yes	2	0	9
8	L:L:?1	R:R:Q450	8.54	Yes	No	2	0	7
9	L:L:?1	R:R:E454	3.19	Yes	No	2	0	5
10	L:L:?1	R:R:F457	5.86	Yes	Yes	0	0	7
11	L:L:?1	R:R:E491	9.56	Yes	No	0	0	6
12	R:R:C151	R:R:C37	7.28	No	No	9	8	9
13	R:R:K111	R:R:K38	7.18	No	No	0	3	4
14	R:R:K39	R:R:V64	4.55	No	No	0	6	5
15	R:R:K39	R:R:V112	3.04	No	Yes	0	6	8
16	R:R:K39	R:R:L114	4.23	No	No	0	6	7
17	R:R:K111	R:R:T40	7.51	No	No	0	3	3
18	R:R:S62	R:R:T41	6.4	Yes	No	6	8	6
19	R:R:T41	R:R:V64	7.93	No	No	6	6	5
20	R:R:T41	R:R:V112	4.76	No	Yes	6	6	8
21	R:R:C43	R:R:L60	3.17	No	No	0	9	4
22	R:R:C107	R:R:C43	7.28	No	No	0	9	9
23	R:R:E44	R:R:Q72	14.02	No	No	0	6	8
24	R:R:L60	R:R:P45	4.93	No	No	0	4	4
25	R:R:L46	R:R:L56	5.54	No	Yes	0	7	7
26	R:R:L46	R:R:T61	7.37	No	No	0	7	9
27	R:R:K47	R:R:Y48	3.58	No	No	0	4	4
28	R:R:K47	R:R:Q72	4.07	No	No	0	4	8
29	R:R:D73	R:R:K47	6.91	No	No	0	4	4
30	R:R:H76	R:R:Y48	27.22	No	No	0	4	4
31	R:R:L462	R:R:N49	10.98	No	No	0	4	5
32	R:R:I50	R:R:V55	3.07	No	No	0	5	4
33	R:R:D182	R:R:I50	13.99	No	No	0	5	5
34	R:R:C51	R:R:L56	4.76	No	Yes	4	9	7
35	R:R:C100	R:R:C51	7.28	No	No	0	9	9
36	R:R:C51	R:R:M104	3.24	No	No	4	9	6
37	R:R:L52	R:R:W92	7.97	No	Yes	0	6	9
38	R:R:E184	R:R:G53	6.55	No	No	0	5	8
39	R:R:I158	R:R:S54	3.1	Yes	No	4	5	5
40	R:R:F160	R:R:S54	13.21	Yes	No	4	8	5
41	R:R:Q165	R:R:V55	2.87	No	No	0	3	4
42	R:R:A465	R:R:V55	5.09	No	No	0	6	4
43	R:R:L56	R:R:P57	3.28	Yes	Yes	4	7	7
44	R:R:L56	R:R:Y58	14.07	Yes	Yes	4	7	9
45	R:R:L56	R:R:M104	4.24	Yes	No	4	7	6
46	R:R:P57	R:R:Y58	5.56	Yes	Yes	4	7	9
47	R:R:I158	R:R:P57	6.77	Yes	Yes	4	5	7
48	R:R:I469	R:R:P57	5.08	Yes	Yes	4	4	7
49	R:R:K106	R:R:Y58	19.11	Yes	Yes	4	6	9
50	R:R:E154	R:R:Y58	3.37	No	Yes	4	5	9
51	R:R:Q72	R:R:T61	4.25	No	No	0	8	9
52	R:R:P105	R:R:T61	3.5	No	No	0	9	9
53	R:R:S62	R:R:V64	4.85	Yes	No	6	8	5
54	R:R:C107	R:R:S62	3.44	No	Yes	6	9	8
55	R:R:S62	R:R:V112	3.23	Yes	Yes	6	8	8
56	R:R:T63	R:R:V75	3.17	No	No	0	5	7
57	R:R:L65	R:R:P115	3.28	No	No	0	8	9
58	R:R:A66	R:R:S69	3.42	No	Yes	0	6	7
59	R:R:A66	R:R:Y103	4	No	Yes	0	6	7
60	R:R:E67	R:R:F139	10.49	No	Yes	1	5	8
61	R:R:E67	R:R:Y146	11.22	No	Yes	1	5	4
62	R:R:D68	R:R:S69	5.89	Yes	Yes	1	6	7
63	R:R:D68	R:R:K78	9.68	Yes	No	1	6	5
64	R:R:D68	R:R:Y103	11.49	Yes	Yes	1	6	7
65	R:R:D68	R:R:F139	9.55	Yes	Yes	1	6	8
66	R:R:D68	W:W:?3	4.35	Yes	Yes	1	6	0
67	R:R:E74	R:R:S69	4.31	No	Yes	1	5	7
68	R:R:S69	R:R:V75	3.23	Yes	No	0	7	7
69	R:R:K78	R:R:S69	6.12	No	Yes	1	5	7
70	R:R:S70	R:R:S71	3.26	No	No	1	3	6
71	R:R:E74	R:R:S70	10.06	No	No	1	5	3
72	R:R:D73	R:R:S71	2.94	No	No	0	4	6
73	R:R:E74	R:R:S71	7.19	No	No	1	5	6
74	R:R:V75	R:R:Y103	3.79	No	Yes	0	7	7
75	R:R:K78	R:R:Y103	7.17	No	Yes	1	5	7
76	R:R:L79	R:R:Y103	7.03	No	Yes	0	9	7
77	R:R:L81	W:W:?3	6.66	No	Yes	0	4	0
78	R:R:I95	R:R:W82	3.52	Yes	Yes	1	8	7
79	R:R:L99	R:R:W82	12.53	No	Yes	1	9	7
80	R:R:W82	R:R:Y103	7.72	Yes	Yes	1	7	7
81	R:R:V130	R:R:W82	3.68	No	Yes	1	7	7
82	R:R:W136	R:R:W82	3.75	Yes	Yes	1	9	7
83	R:R:P137	R:R:W82	4.05	Yes	Yes	1	9	7
84	R:R:L140	R:R:W82	3.42	Yes	Yes	1	7	7
85	R:R:W82	W:W:?3	8.22	Yes	Yes	1	7	0
86	R:R:R86	R:R:S83	6.59	No	No	0	6	5
87	R:R:C91	R:R:L85	6.35	No	No	1	9	9
88	R:R:L85	R:R:W92	5.69	No	Yes	1	9	9
89	R:R:I95	R:R:L85	2.85	Yes	No	1	8	9
90	R:R:R86	R:R:W92	5	No	Yes	0	6	9
91	R:R:C91	R:R:I95	3.27	No	Yes	1	9	8
92	R:R:C127	R:R:C91	7.28	No	No	1	9	9
93	R:R:I95	R:R:W92	3.52	Yes	Yes	1	8	9
94	R:R:R96	R:R:W92	23.99	No	Yes	0	8	9
95	R:R:I95	R:R:L99	7.14	Yes	No	1	8	9
96	R:R:C127	R:R:I95	6.55	No	Yes	1	9	8
97	R:R:F160	R:R:R96	17.1	Yes	No	0	8	8
98	R:R:E184	R:R:R96	8.14	No	No	0	5	8
99	R:R:L119	R:R:P97	3.28	Yes	No	0	6	7
100	R:R:C120	R:R:L98	3.17	Yes	Yes	1	9	8
101	R:R:L98	R:R:T123	8.84	Yes	No	0	8	8
102	R:R:F147	R:R:L98	3.65	Yes	Yes	1	8	8
103	R:R:C100	R:R:V155	3.42	No	No	0	9	5
104	R:R:C100	R:R:F160	4.19	No	Yes	0	9	8
105	R:R:A101	R:R:P115	3.74	No	No	0	8	9
106	R:R:A101	R:R:V155	3.39	No	No	0	8	5
107	R:R:L140	R:R:V102	4.47	Yes	No	0	7	6
108	R:R:F139	R:R:Y103	5.16	Yes	Yes	1	8	7
109	R:R:E108	R:R:K106	8.1	No	Yes	0	5	6
110	R:R:E113	R:R:K106	10.8	No	Yes	4	5	6
111	R:R:E154	R:R:K106	12.15	No	Yes	4	5	6
112	R:R:C107	R:R:V112	3.42	No	Yes	6	9	8
113	R:R:E113	R:R:E154	8.88	No	No	4	5	5
114	R:R:L114	R:R:P148	3.28	No	No	0	7	7
115	R:R:F147	R:R:P115	7.22	Yes	No	0	8	9
116	R:R:L119	R:R:S116	3	Yes	No	1	6	9
117	R:R:N153	R:R:S116	4.47	No	No	1	7	9
118	R:R:Q117	R:R:Q121	10.24	Yes	No	1	6	5
119	R:R:C142	R:R:Q117	4.58	Yes	Yes	1	9	6
120	R:R:E149	R:R:Q117	3.82	No	Yes	0	3	6
121	R:R:L119	R:R:N153	5.49	Yes	No	1	6	7
122	R:R:C120	R:R:R124	4.18	Yes	Yes	1	9	6
123	R:R:C120	R:R:C142	7.28	Yes	Yes	1	9	9
124	R:R:C120	R:R:F147	15.36	Yes	Yes	1	9	8
125	R:R:Q121	R:R:R124	3.5	No	Yes	1	5	6
126	R:R:C142	R:R:Q121	3.05	Yes	No	1	9	5
127	R:R:R124	R:R:T123	9.06	Yes	No	0	6	8
128	R:R:R124	R:R:W136	29.99	Yes	Yes	1	6	9
129	R:R:C142	R:R:R124	8.36	Yes	Yes	1	9	6
130	R:R:P126	R:R:V125	3.53	No	No	0	7	3
131	R:R:A128	R:R:R132	4.15	No	No	0	5	4
132	R:R:E133	R:R:I129	10.93	No	No	0	4	6
133	R:R:V130	R:R:W136	15.94	No	Yes	1	7	9
134	R:R:V130	W:W:?3	3.58	No	Yes	1	7	0
135	R:R:E133	W:W:?3	18.07	No	Yes	0	4	0
136	R:R:R134	W:W:?3	8.77	No	Yes	0	5	0
137	R:R:P137	R:R:W136	5.4	Yes	Yes	1	9	9
138	R:R:L140	R:R:W136	4.56	Yes	Yes	1	7	9
139	R:R:F139	R:R:P137	5.78	Yes	Yes	1	8	9
140	R:R:L140	R:R:P137	13.14	Yes	Yes	1	7	9
141	R:R:P137	W:W:?3	6.58	Yes	Yes	1	9	0
142	R:R:D138	R:R:K141	6.91	No	No	0	4	4
143	R:R:F139	R:R:L140	7.31	Yes	Yes	1	8	7
144	R:R:F139	R:R:Y146	3.09	Yes	Yes	1	8	4
145	R:R:D145	R:R:T143	8.67	No	No	1	5	5
146	R:R:T143	R:R:Y146	4.99	No	Yes	1	5	4
147	R:R:E149	R:R:T144	7.06	No	No	0	3	4
148	R:R:D145	R:R:Y146	9.2	No	Yes	1	5	4
149	R:R:F147	R:R:Y146	3.09	Yes	Yes	1	8	4
150	R:R:C151	R:R:P148	3.77	No	No	0	8	7
151	R:R:N153	R:R:Q156	10.56	No	No	0	7	5
152	R:R:I469	R:R:N157	4.25	Yes	No	4	4	4
153	R:R:N157	R:R:T473	7.31	No	No	4	4	4
154	R:R:F160	R:R:I158	5.02	Yes	Yes	4	8	5
155	R:R:I158	R:R:I469	2.94	Yes	Yes	4	5	4
156	R:R:Q165	R:R:S162	2.89	No	No	0	3	6
157	R:R:C166	R:R:S162	3.44	No	No	0	9	6
158	R:R:G185	R:R:S162	3.71	No	No	0	8	6
159	R:R:C166	R:R:R172	4.18	No	No	0	9	4
160	R:R:C166	R:R:C186	7.28	No	No	0	9	9
161	R:R:E167	R:R:E464	8.88	No	Yes	0	6	4
162	R:R:A468	R:R:E167	6.03	No	No	0	6	6
163	R:R:P169	R:R:Q189	6.32	No	No	2	8	7
164	R:R:P169	R:R:P193	3.9	No	Yes	2	8	8
165	R:R:P169	R:R:Y460	8.34	No	No	0	8	5
166	R:R:L170	R:R:Y180	3.52	No	No	0	9	8
167	R:R:I188	R:R:L170	2.85	No	No	0	6	9
168	R:R:D174	R:R:R172	7.15	No	No	0	6	4
169	R:R:S178	R:R:T173	4.8	Yes	No	5	8	8
170	R:R:D271	R:R:T173	13.01	Yes	No	5	8	8
171	R:R:N175	R:R:P176	4.89	Yes	No	0	6	3
172	R:R:K177	R:R:N175	9.79	Yes	Yes	5	4	6
173	R:R:N175	R:R:S178	5.96	Yes	Yes	5	6	8
174	R:R:N175	R:R:R269	3.62	Yes	Yes	5	6	7
175	R:R:D271	R:R:N175	4.04	Yes	Yes	5	8	6
176	R:R:P176	R:R:W179	9.46	No	No	0	3	5
177	R:R:K177	R:R:R269	4.95	Yes	Yes	5	4	7
178	R:R:K177	R:R:T280	4.5	Yes	No	5	4	7
179	R:R:K177	R:R:S281	4.59	Yes	No	0	4	8
180	R:R:R269	R:R:S178	7.91	Yes	Yes	5	7	8
181	R:R:D271	R:R:S178	8.83	Yes	Yes	5	8	8
182	R:R:S178	R:R:T273	6.4	Yes	Yes	5	8	8
183	R:R:G185	R:R:W179	5.63	No	No	0	8	5
184	R:R:E181	R:R:Y180	24.69	No	No	10	4	8
185	R:R:R458	R:R:Y180	6.17	No	No	10	5	8
186	R:R:E181	R:R:R458	5.82	No	No	10	4	5
187	R:R:C186	R:R:V183	3.42	No	No	0	9	7
188	R:R:F457	R:R:I188	3.77	Yes	No	0	7	6
189	R:R:P193	R:R:Q189	4.74	Yes	No	2	8	7
190	R:R:C190	R:R:C268	7.28	No	No	11	9	9
191	R:R:N197	R:R:Q191	6.6	No	No	0	3	4
192	R:R:H200	R:R:Q191	18.54	Yes	No	2	8	4
193	R:R:Q191	R:R:S358	4.33	No	No	2	4	8
194	R:R:N192	R:R:P193	6.52	Yes	Yes	2	7	8
195	R:R:L194	R:R:N192	5.49	Yes	Yes	2	6	7
196	R:R:F195	R:R:N192	8.46	Yes	Yes	2	6	7
197	R:R:D357	R:R:N192	5.39	Yes	Yes	2	8	7
198	R:R:N192	R:R:V359	4.43	Yes	Yes	2	7	7
199	R:R:F457	R:R:P193	5.78	Yes	Yes	0	7	8
200	R:R:F195	R:R:L194	4.87	Yes	Yes	2	6	6
201	R:R:I482	R:R:L194	2.85	No	Yes	0	4	6
202	R:R:L194	R:R:P486	4.93	Yes	Yes	2	6	9
203	R:R:E199	R:R:F195	5.83	Yes	Yes	2	8	6
204	R:R:F195	R:R:V359	3.93	Yes	Yes	2	6	7
205	R:R:F195	R:R:R485	5.34	Yes	Yes	2	6	7
206	R:R:F195	R:R:P486	8.67	Yes	Yes	2	6	9
207	R:R:F195	R:R:L488	8.53	Yes	No	2	6	6
208	R:R:E199	R:R:T196	8.47	Yes	No	0	8	8
209	R:R:E199	R:R:R485	9.3	Yes	Yes	2	8	7
210	R:R:E199	R:R:L488	7.95	Yes	No	2	8	6
211	R:R:H200	R:R:H204	4.78	Yes	No	2	8	8
212	R:R:H200	R:R:S358	6.97	Yes	No	2	8	8
213	R:R:H200	R:R:V359	5.54	Yes	Yes	2	8	7
214	R:R:E202	R:R:K492	5.4	No	No	0	7	8
215	R:R:I207	R:R:M203	2.92	No	No	0	7	8
216	R:R:M203	R:R:V359	4.56	No	Yes	0	8	7
217	R:R:H204	R:R:Q257	3.71	No	Yes	2	8	9
218	R:R:H204	R:R:R263	28.21	No	Yes	2	8	8
219	R:R:F210	R:R:Y206	9.28	No	No	0	5	7
220	R:R:K492	R:R:Y206	15.53	No	No	0	8	7
221	R:R:L495	R:R:Y206	3.52	Yes	No	0	8	7
222	R:R:I207	R:R:W254	3.52	No	Yes	7	7	7
223	R:R:I207	R:R:L495	2.85	No	Yes	7	7	8
224	R:R:A208	R:R:F258	4.16	No	No	0	6	8
225	R:R:F210	R:R:F496	5.36	No	No	0	5	6
226	R:R:F210	R:R:F499	8.57	No	Yes	0	5	9
227	R:R:S211	R:R:S251	3.26	No	No	0	7	8
228	R:R:L255	R:R:S211	7.51	No	No	0	7	7
229	R:R:F499	R:R:S211	6.61	Yes	No	0	9	7
230	R:R:I503	R:R:V213	4.61	No	No	0	8	5
231	R:R:S251	R:R:T214	4.8	No	No	0	8	8
232	R:R:F499	R:R:T214	6.49	Yes	No	0	9	8
233	R:R:I503	R:R:T214	4.56	No	No	0	8	8
234	R:R:F248	R:R:I215	7.54	Yes	Yes	12	6	5
235	R:R:I215	R:R:S251	4.64	Yes	No	0	5	8
236	R:R:I215	R:R:I252	2.94	Yes	No	12	5	6
237	R:R:I215	R:R:L255	5.71	Yes	No	0	5	7
238	R:R:C217	R:R:S506	5.16	No	Yes	0	6	9
239	R:R:N244	R:R:T218	7.31	No	No	0	9	9
240	R:R:F248	R:R:T218	9.08	Yes	No	0	6	9
241	R:R:F219	R:R:F248	4.29	No	Yes	0	6	6
242	R:R:N244	R:R:T221	14.62	No	No	13	9	9
243	R:R:S506	R:R:T221	3.2	Yes	No	13	9	9
244	R:R:T221	R:R:V509	11.11	No	Yes	0	9	8
245	R:R:F241	R:R:L222	7.31	Yes	No	0	9	7
246	R:R:F248	R:R:L222	3.65	Yes	No	0	6	7
247	R:R:T224	R:R:V509	4.76	No	Yes	0	9	8
248	R:R:T224	R:R:T514	6.28	No	No	0	9	9
249	R:R:T224	R:R:W518	3.64	No	No	0	9	9
250	R:R:F225	R:R:S232	6.61	Yes	No	0	9	8
251	R:R:F225	R:R:F241	7.5	Yes	Yes	0	9	9
252	R:R:F225	R:R:V509	5.24	Yes	Yes	0	9	8
253	R:R:V227	R:R:W518	7.36	No	No	0	8	9
254	R:R:D228	R:R:N231	13.46	Yes	No	0	9	8
255	R:R:D228	R:R:S232	5.89	Yes	No	0	9	8
256	R:R:D228	R:R:I517	5.6	Yes	No	0	9	7
257	R:R:N233	R:R:W229	21.47	No	No	0	8	8
258	R:R:V238	R:R:Y235	8.83	Yes	Yes	3	7	9
259	R:R:I239	R:R:Y235	3.63	Yes	Yes	0	8	9
260	R:R:Y235	R:R:Y242	2.98	Yes	Yes	3	9	8
261	R:R:T330	R:R:Y235	17.48	No	Yes	0	7	9
262	R:R:I239	R:R:P236	3.39	Yes	No	0	8	9
263	R:R:A311	R:R:P236	3.74	No	No	0	8	9
264	R:R:P236	R:R:W312	5.4	No	Yes	0	9	7
265	R:R:F241	R:R:V238	3.93	Yes	Yes	3	9	7
266	R:R:V238	R:R:Y242	8.83	Yes	Yes	3	7	8
267	R:R:I239	R:R:W304	5.87	Yes	Yes	0	8	9
268	R:R:I239	R:R:L308	4.28	Yes	No	0	8	8
269	R:R:L240	R:R:L308	4.15	No	No	0	8	8
270	R:R:F241	R:R:Y242	5.16	Yes	Yes	3	9	8
271	R:R:W304	R:R:Y242	14.47	Yes	Yes	3	9	8
272	R:R:H334	R:R:Y242	10.89	No	Yes	3	9	8
273	R:R:F305	R:R:V243	3.93	Yes	No	8	8	8
274	R:R:M505	R:R:V243	3.04	Yes	No	8	9	8
275	R:R:N244	R:R:S506	4.47	No	Yes	13	9	9
276	R:R:C246	R:R:S300	5.16	No	Yes	3	9	9
277	R:R:C246	R:R:G301	3.92	No	No	3	9	8
278	R:R:F247	R:R:G301	3.01	No	No	0	8	8
279	R:R:F247	R:R:G502	6.02	No	No	0	8	9
280	R:R:F248	R:R:I252	7.54	Yes	No	12	6	6
281	R:R:G250	R:R:S297	3.71	No	No	0	7	8
282	R:R:G253	R:R:I252	3.53	No	No	0	8	6
283	R:R:G253	R:R:I293	3.53	No	No	0	8	6
284	R:R:V294	R:R:W254	8.58	No	Yes	0	8	7
285	R:R:I362	R:R:W254	7.05	No	Yes	0	9	7
286	R:R:L495	R:R:W254	3.42	Yes	Yes	7	8	7
287	R:R:F499	R:R:W254	8.02	Yes	Yes	7	9	7
288	R:R:F258	R:R:Q257	12.88	No	Yes	2	8	9
289	R:R:Q257	R:R:R263	10.51	Yes	Yes	2	9	8
290	R:R:G361	R:R:Q257	8.22	No	Yes	0	9	9
291	R:R:F258	R:R:R263	6.41	No	Yes	2	8	8
292	R:R:A262	R:R:M259	4.83	No	No	0	7	5
293	R:R:C268	R:R:D264	4.67	No	No	0	9	5
294	R:R:E265	R:R:T284	7.06	No	No	14	7	8
295	R:R:E265	R:R:S286	8.62	No	No	14	7	8
296	R:R:I266	R:R:I290	10.3	No	No	0	8	7
297	R:R:D271	R:R:R269	7.15	Yes	Yes	5	8	7
298	R:R:R269	R:R:T273	3.88	Yes	Yes	5	7	8
299	R:R:R269	R:R:T280	5.17	Yes	No	5	7	7
300	R:R:E283	R:R:R269	6.98	No	Yes	0	8	7
301	R:R:D271	R:R:T273	10.12	Yes	Yes	5	8	8
302	R:R:L276	R:R:M274	8.48	No	No	0	4	5
303	R:R:E278	R:R:R275	15.12	No	Yes	0	8	7
304	R:R:E283	R:R:R275	4.65	No	Yes	0	8	7
305	R:R:R275	R:R:T284	5.17	Yes	No	0	7	8
306	R:R:C287	R:R:R275	6.96	No	Yes	0	9	7
307	R:R:D355	R:R:L276	6.79	Yes	No	0	9	4
308	R:R:E278	R:R:T280	5.64	No	No	0	8	7
309	R:R:E278	R:R:V354	2.85	No	No	0	8	8
310	R:R:P279	R:R:V288	5.3	No	No	0	8	8
311	R:R:S286	R:R:T284	4.8	No	No	14	8	8
312	R:R:L285	R:R:V288	5.96	No	No	0	7	8
313	R:R:C287	R:R:C363	7.28	No	No	0	9	9
314	R:R:I289	R:R:I290	2.94	No	No	0	6	7
315	R:R:I290	R:R:I362	2.94	No	No	0	7	9
316	R:R:F291	R:R:Y295	7.22	Yes	Yes	3	9	9
317	R:R:F291	R:R:I348	10.05	Yes	Yes	3	9	7
318	R:R:F291	R:R:L349	3.65	Yes	No	0	9	8
319	R:R:F291	R:R:V354	13.11	Yes	No	0	9	8
320	R:R:I292	R:R:L349	2.85	No	No	0	7	8
321	R:R:M299	R:R:Y295	13.17	Yes	Yes	0	8	9
322	R:R:L344	R:R:Y295	5.86	Yes	Yes	3	8	9
323	R:R:T345	R:R:Y295	6.24	No	Yes	0	9	9
324	R:R:I348	R:R:Y295	8.46	Yes	Yes	3	7	9
325	R:R:F364	R:R:Y295	4.13	No	Yes	0	9	9
326	R:R:F376	R:R:Y295	6.19	Yes	Yes	3	8	9
327	R:R:W338	R:R:Y296	7.72	Yes	Yes	0	9	8
328	R:R:P341	R:R:Y296	6.95	Yes	Yes	0	9	8
329	R:R:T345	R:R:Y296	3.75	No	Yes	0	9	8
330	R:R:M298	R:R:M299	4.33	No	Yes	0	7	8
331	R:R:M298	R:R:M498	2.89	No	No	0	7	6
332	R:R:M299	R:R:P341	3.35	Yes	Yes	0	8	9
333	R:R:M299	R:R:P380	3.35	Yes	No	0	8	9
334	R:R:G301	R:R:S300	3.71	No	Yes	3	8	9
335	R:R:S300	R:R:W338	7.41	Yes	Yes	3	9	9
336	R:R:P341	R:R:S300	3.56	Yes	Yes	3	9	9
337	R:R:V302	R:R:V384	4.81	No	No	0	6	6
338	R:R:I303	R:R:T337	4.56	Yes	No	3	7	9
339	R:R:I303	R:R:I340	4.42	Yes	Yes	3	7	5
340	R:R:I303	R:R:P341	3.39	Yes	Yes	3	7	9
341	R:R:M307	R:R:W304	4.65	No	Yes	0	7	9
342	R:R:H334	R:R:W304	5.29	No	Yes	3	9	9
343	R:R:T337	R:R:W304	27.9	No	Yes	3	9	9
344	R:R:W304	R:R:W338	8.43	Yes	Yes	3	9	9
345	R:R:F305	R:R:F428	4.29	Yes	Yes	0	8	8
346	R:R:F305	R:R:T501	3.89	Yes	No	8	8	7
347	R:R:F305	R:R:M505	7.46	Yes	Yes	8	8	9
348	R:R:M307	R:R:V306	3.04	No	No	0	7	9
349	R:R:V306	R:R:V384	4.81	No	No	0	9	6
350	R:R:F333	R:R:M307	4.98	No	No	0	9	7
351	R:R:L308	R:R:W312	19.36	No	Yes	0	8	7
352	R:R:G388	R:R:T309	5.46	No	No	0	8	8
353	R:R:F391	R:R:T309	5.19	Yes	No	0	8	8
354	R:R:T314	R:R:Y310	8.74	No	Yes	0	6	8
355	R:R:K329	R:R:Y310	5.97	No	Yes	15	8	8
356	R:R:F333	R:R:Y310	4.13	No	Yes	15	9	8
357	R:R:F391	R:R:Y310	10.32	Yes	Yes	0	8	8
358	R:R:L425	R:R:W312	4.56	No	Yes	0	8	7
359	R:R:F428	R:R:W312	5.01	Yes	Yes	0	8	7
360	R:R:W312	R:R:W508	5.62	Yes	No	0	7	9
361	R:R:H313	R:R:K317	6.55	Yes	No	0	7	5
362	R:R:F391	R:R:H313	4.53	Yes	Yes	0	8	7
363	R:R:H313	R:R:R394	13.54	Yes	No	0	7	7
364	R:R:F316	R:R:G395	3.01	No	No	0	8	8
365	R:R:S327	R:R:T330	3.2	No	No	0	6	7
366	R:R:F333	R:R:K329	3.72	No	No	15	9	8
367	R:R:H334	R:R:W338	12.7	No	Yes	3	9	9
368	R:R:T337	R:R:W338	4.85	No	Yes	3	9	9
369	R:R:I340	R:R:P341	3.39	Yes	Yes	3	5	9
370	R:R:I340	R:R:L344	2.85	Yes	Yes	3	5	8
371	R:R:F342	R:R:V346	7.87	No	No	0	9	8
372	R:R:F376	R:R:L344	6.09	Yes	Yes	3	8	8
373	R:R:L344	R:R:P380	3.28	Yes	No	0	8	9
374	R:R:I348	R:R:V365	9.22	Yes	No	0	7	9
375	R:R:F376	R:R:I348	15.07	Yes	Yes	3	8	7
376	R:R:Q353	R:R:V351	2.87	Yes	No	16	7	6
377	R:R:V351	R:R:Y372	5.05	No	No	16	6	5
378	R:R:D355	R:R:Q353	3.92	Yes	Yes	0	9	7
379	R:R:N369	R:R:Q353	11.88	No	Yes	0	8	7
380	R:R:Q353	R:R:Y372	13.53	Yes	No	16	7	5
381	R:R:D355	R:R:Y367	5.75	Yes	Yes	0	9	5
382	R:R:D355	R:R:K368	4.15	Yes	No	0	9	4
383	R:R:D357	R:R:V359	8.76	Yes	Yes	2	8	7
384	R:R:D357	R:R:S360	10.31	Yes	No	0	8	8
385	R:R:D357	R:R:Y367	4.6	Yes	Yes	2	8	5
386	R:R:I362	R:R:S360	7.74	No	No	0	9	8
387	R:R:F364	R:R:V365	6.55	No	No	0	9	9
388	R:R:F364	R:R:Y367	9.28	No	Yes	0	9	5
389	R:R:G366	R:R:V365	3.68	No	No	0	9	9
390	R:R:R373	R:R:Y367	3.09	Yes	Yes	2	9	5
391	R:R:K368	R:R:N369	13.99	No	No	0	4	8
392	R:R:H371	R:R:Y370	18.51	No	Yes	2	3	4
393	R:R:F447	R:R:Y370	9.28	No	Yes	2	6	4
394	R:R:Q450	R:R:Y370	20.29	No	Yes	2	7	4
395	R:R:F447	R:R:H371	9.05	No	No	2	6	3
396	R:R:H443	R:R:R373	11.28	No	Yes	0	9	9
397	R:R:D446	R:R:R373	3.57	Yes	Yes	2	7	9
398	R:R:A374	R:R:F447	4.16	No	No	0	6	6
399	R:R:L378	R:R:V377	2.98	No	No	0	7	8
400	R:R:F440	R:R:L378	9.74	No	No	0	6	7
401	R:R:H443	R:R:L378	6.43	No	No	0	9	7
402	R:R:I381	R:R:V436	3.07	No	No	0	7	8
403	R:R:F440	R:R:G382	3.01	No	No	0	6	4
404	R:R:F433	R:R:L385	3.65	No	No	0	5	6
405	R:R:L385	R:R:V436	11.92	No	No	0	6	8
406	R:R:G387	R:R:I386	3.53	No	No	0	6	4
407	R:R:F391	R:R:Y390	13.41	Yes	No	0	8	5
408	R:R:R394	R:R:Y390	4.12	No	No	0	7	5
409	R:R:F428	R:R:L392	7.31	Yes	No	0	8	7
410	R:R:I393	R:R:V396	3.07	No	No	0	5	8
411	R:R:G395	R:R:T398	3.64	No	No	0	8	7
412	R:R:F400	R:R:M397	3.73	No	No	0	7	5
413	R:R:I418	R:R:L399	4.28	No	No	0	9	9
414	R:R:L399	R:R:M422	4.24	No	No	0	9	8
415	R:R:L423	R:R:N419	5.49	No	No	0	7	6
416	R:R:R424	R:R:W508	4	No	No	0	9	9
417	R:R:F428	R:R:G429	3.01	Yes	No	0	8	7
418	R:R:A432	R:R:F428	4.16	No	Yes	0	7	8
419	R:R:F435	R:R:L431	6.09	No	No	0	7	6
420	R:R:L431	R:R:S504	6.01	No	No	0	6	7
421	R:R:F435	R:R:G500	4.52	No	No	0	7	6
422	R:R:F435	R:R:T501	10.38	No	No	0	7	7
423	R:R:I438	R:R:L437	2.85	No	No	0	5	4
424	R:R:N494	R:R:T439	5.85	No	No	0	8	8
425	R:R:F440	R:R:F444	4.29	No	No	0	6	5
426	R:R:C442	R:R:V490	3.42	No	Yes	0	7	7
427	R:R:C442	R:R:I493	3.27	No	No	0	7	6
428	R:R:C442	R:R:N494	7.87	No	No	0	7	8
429	R:R:H443	R:R:N494	10.2	No	No	0	9	8
430	R:R:F444	R:R:F448	4.29	No	No	0	5	3
431	R:R:D446	R:R:Y445	3.45	Yes	Yes	2	7	8
432	R:R:N449	R:R:Y445	5.81	No	Yes	2	7	8
433	R:R:W453	R:R:Y445	6.75	Yes	Yes	2	9	8
434	R:R:V490	R:R:Y445	6.31	Yes	Yes	0	7	8
435	R:R:D446	R:R:W453	6.7	Yes	Yes	2	7	9
436	R:R:D446	R:R:E491	7.8	Yes	No	0	7	6
437	R:R:N449	R:R:W453	9.04	No	Yes	2	7	9
438	R:R:E454	R:R:Q450	3.82	No	No	2	5	7
439	R:R:E452	R:R:R455	6.98	No	No	0	2	4
440	R:R:E452	R:R:N484	10.52	No	Yes	0	2	4
441	R:R:N484	R:R:W453	5.65	Yes	Yes	2	4	9
442	R:R:P486	R:R:W453	27.02	Yes	Yes	2	9	9
443	R:R:I482	R:R:S456	3.1	No	No	0	4	8
444	R:R:K483	R:R:S456	3.06	No	No	2	3	8
445	R:R:N484	R:R:S456	7.45	Yes	No	2	4	8
446	R:R:F457	R:R:V461	7.87	Yes	No	0	7	6
447	R:R:E464	R:R:Y460	8.98	Yes	No	0	4	5
448	R:R:I482	R:R:Y460	3.63	No	No	0	4	5
449	R:R:C463	R:R:C480	7.28	No	No	0	9	9
450	R:R:E464	R:R:V467	5.7	Yes	No	0	4	6
451	R:R:C480	R:R:E464	7.6	No	Yes	0	9	4
452	R:R:N466	R:R:P478	6.52	No	No	0	7	4
453	R:R:E471	R:R:V467	5.7	No	No	0	2	6
454	R:R:I469	R:R:T473	3.04	Yes	No	4	4	4
455	R:R:A470	R:R:I477	3.25	No	No	0	4	4
456	R:R:E471	R:R:I477	5.47	No	No	0	2	4
457	R:R:K475	R:R:T473	4.5	No	No	0	4	4
458	R:R:K475	R:R:P476	5.02	No	No	0	4	4
459	R:R:K483	R:R:N484	5.6	No	Yes	2	3	4
460	R:R:P486	R:R:R485	2.88	Yes	Yes	2	9	7
461	R:R:L488	R:R:R485	4.86	No	Yes	2	6	7
462	R:R:S487	R:R:V490	4.85	No	Yes	0	8	7
463	R:R:E491	R:R:V490	2.85	No	Yes	0	6	7
464	R:R:F499	R:R:L495	4.87	Yes	Yes	7	9	8
465	R:R:M505	R:R:T501	3.01	Yes	No	8	9	7
466	R:R:I503	R:R:S506	3.1	No	Yes	0	8	9
467	R:R:M505	R:R:S504	6.13	Yes	No	0	9	7
468	R:R:T511	R:R:T514	4.71	No	No	0	9	9
469	R:R:H76	R:R:S80	2.79	No	No	0	4	3
470	R:R:L114	R:R:L65	2.77	No	No	0	7	8
471	R:R:L119	R:R:L98	2.77	Yes	Yes	1	6	8
472	R:R:A237	R:R:R234	2.77	No	No	0	9	7
473	R:R:A347	R:R:F376	2.77	No	Yes	0	6	8
474	R:R:L46	R:R:N49	2.75	No	No	0	7	5
475	R:R:H313	R:R:T398	2.74	Yes	No	0	7	7
476	R:R:F316	R:R:S315	2.64	No	No	0	8	8
477	R:R:A131	R:R:W136	2.59	No	Yes	0	5	9
478	R:R:A223	R:R:W518	2.59	No	No	0	6	9
479	R:R:F316	R:R:T421	2.59	No	No	0	8	8
480	R:R:F216	R:R:I215	2.51	No	Yes	0	3	5
481	R:R:V509	R:R:W510	2.45	Yes	No	0	8	8
482	R:R:D264	R:R:R263	2.38	No	Yes	0	5	8
483	R:R:L335	R:R:Y332	2.34	No	No	0	6	7
484	R:R:E184	R:R:W179	2.18	No	No	0	5	5
485	R:R:G109	R:R:G110	2.11	No	No	0	5	5
486	R:R:G387	R:R:G388	2.11	No	No	0	6	8
487	R:R:G388	R:R:G389	2.11	No	No	0	8	6
488	R:R:F220	R:R:W510	2	No	No	0	8	8
489	R:R:C43	R:R:G110	1.96	No	No	0	9	5
490	R:R:C190	R:R:G272	1.96	No	No	11	9	5
491	R:R:C268	R:R:G272	1.96	No	No	11	9	5
492	R:R:C363	R:R:G356	1.96	No	No	0	9	8
493	R:R:A163	R:R:G164	1.95	No	No	0	7	6
494	R:R:A249	R:R:G250	1.95	No	No	0	5	7
495	R:R:A256	R:R:G253	1.95	No	No	0	6	8
496	R:R:A374	R:R:G375	1.95	No	No	0	6	5
497	R:R:C37	R:R:P152	1.88	No	No	9	9	5
498	R:R:C127	R:R:P126	1.88	No	No	0	9	7
499	R:R:C151	R:R:P152	1.88	No	No	9	8	5
500	R:R:A88	R:R:P89	1.87	No	No	0	7	9
501	R:R:A94	R:R:P126	1.87	No	No	0	8	7
502	R:R:A352	R:R:P279	1.87	No	No	0	7	8
503	R:R:A379	R:R:P380	1.87	No	No	0	6	9
504	R:R:A470	R:R:P478	1.87	No	No	0	4	4
505	R:R:G84	R:R:S83	1.86	No	No	0	6	5
506	R:R:G356	R:R:V267	1.84	No	No	0	8	8
507	R:R:G361	R:R:V267	1.84	No	No	0	9	8
508	R:R:G187	R:R:T173	1.82	No	No	0	8	8
509	R:R:G187	R:R:T273	1.82	No	Yes	0	8	8
510	R:R:G250	R:R:I293	1.76	No	No	0	7	6
511	R:R:G382	R:R:I381	1.76	No	No	0	4	7
512	R:R:G110	R:R:K111	1.74	No	No	0	5	3
513	R:R:G434	R:R:L437	1.71	No	No	0	5	4
514	R:R:A521	R:R:V227	1.7	No	No	0	7	8
515	R:R:D355	R:R:G277	1.68	Yes	No	0	9	6
516	R:R:A513	R:R:T511	1.68	No	No	0	8	9
517	R:R:G118	R:R:Q117	1.64	No	Yes	0	6	6
518	R:R:E283	R:R:G270	1.64	No	No	0	8	5
519	R:R:L349	R:R:P279	1.64	No	No	0	8	8
520	R:R:S281	R:R:S282	1.63	No	No	0	8	7
521	R:R:A497	R:R:I438	1.62	No	No	0	8	5
522	R:R:S506	R:R:T507	1.6	Yes	No	0	9	8
523	R:R:T273	R:R:V171	1.59	Yes	No	0	8	7
524	R:R:A245	R:R:L222	1.58	No	No	0	6	7
525	R:R:T122	R:R:T123	1.57	No	No	0	4	8
526	R:R:I209	R:R:V213	1.54	No	No	0	5	5
527	R:R:F444	R:R:G441	1.51	No	No	0	5	5
528	R:R:K198	R:R:T196	1.5	No	No	0	3	8
529	R:R:L255	R:R:S212	1.5	No	No	0	7	6
530	R:R:L326	R:R:S327	1.5	No	No	0	8	6
531	R:R:L489	R:R:S487	1.5	No	No	0	5	8
532	R:R:L425	R:R:V396	1.49	No	No	0	8	8
533	R:R:N233	R:R:V238	1.48	No	Yes	0	8	7
534	R:R:I303	R:R:I336	1.47	Yes	No	3	7	5
535	R:R:I336	R:R:I340	1.47	No	Yes	3	5	5
536	R:R:I438	R:R:I493	1.47	No	No	0	5	6
537	R:R:I516	R:R:I517	1.47	No	No	0	4	7
538	R:R:I427	R:R:L431	1.43	No	No	0	6	6
539	R:R:M422	R:R:N419	1.4	No	No	0	8	6
540	R:R:A237	R:R:F225	1.39	No	Yes	0	9	9
541	R:R:A451	R:R:Y370	1.33	No	Yes	0	3	4
542	R:R:E459	R:R:L462	1.33	No	No	0	3	4
543	R:R:F342	R:R:V343	1.31	No	No	0	9	6
544	R:R:A521	R:R:W522	1.3	No	No	0	7	4
545	R:R:I525	R:R:R524	1.25	No	No	0	5	7
546	R:R:N87	R:R:R86	1.21	No	No	0	5	6
547	R:R:D228	R:R:R520	1.19	Yes	No	0	9	7
548	R:R:K483	R:R:Y481	1.19	No	No	0	3	3
549	R:R:K141	R:R:W136	1.16	No	Yes	0	4	9
550	R:R:F342	R:R:Y296	1.03	No	Yes	0	9	8

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	L:L:?1	8.04545	11	2	0
2	R:R:L56	6.378	5	4	7
3	R:R:P57	5.1725	4	4	7
4	R:R:Y58	10.5275	4	4	9
5	R:R:S62	4.48	4	6	8
6	R:R:D68	8.192	5	1	6
7	R:R:S69	4.594	5	1	7
8	R:R:W82	5.86125	8	1	7
9	R:R:W92	9.234	5	1	9
10	R:R:I95	4.475	6	1	8
11	R:R:L98	4.6075	4	1	8
12	R:R:Y103	6.62286	7	1	7
13	R:R:K106	12.54	4	4	6
14	R:R:V112	3.6125	4	6	8
15	R:R:Q117	5.07	4	1	6
16	R:R:L119	3.635	4	1	6
17	R:R:C120	7.4975	4	1	9
18	R:R:R124	11.018	5	1	6
19	R:R:W136	9.05571	7	1	9
20	R:R:P137	6.99	5	1	9
21	R:R:F139	6.89667	6	1	8
22	R:R:L140	6.58	5	1	7
23	R:R:C142	5.8175	4	1	9
24	R:R:Y146	6.318	5	1	4
25	R:R:F147	7.33	4	1	8
26	R:R:I158	4.4575	4	4	5
27	R:R:F160	9.88	4	4	8
28	R:R:N175	5.66	5	5	6
29	R:R:K177	5.9575	4	5	4
30	R:R:S178	6.78	5	5	8
31	R:R:N192	7.06667	6	2	7
32	R:R:P193	5.235	4	2	8
33	R:R:L194	4.738	5	2	6
34	R:R:F195	6.07	8	2	6
35	R:R:E199	7.8875	4	2	8
36	R:R:H200	8.9575	4	2	8
37	R:R:I215	4.668	5	12	5
38	R:R:F225	5.185	4	0	9
39	R:R:D228	6.535	4	0	9
40	R:R:Y235	8.23	4	3	9
41	R:R:V238	5.7675	4	3	7
42	R:R:I239	4.2925	4	0	8
43	R:R:F241	5.975	4	3	9
44	R:R:Y242	8.466	5	3	8
45	R:R:F248	6.42	5	12	6
46	R:R:W254	6.118	5	7	7
47	R:R:Q257	8.83	4	2	9
48	R:R:R263	11.8775	4	2	8
49	R:R:R269	5.66571	7	5	7
50	R:R:D271	8.63	5	5	8
51	R:R:T273	4.762	5	5	8
52	R:R:R275	7.975	4	0	7
53	R:R:F291	8.5075	4	3	9
54	R:R:Y295	7.32429	7	3	9
55	R:R:Y296	4.8625	4	0	8
56	R:R:M299	6.05	4	0	8
57	R:R:S300	4.96	4	3	9
58	R:R:I303	3.46	4	3	7
59	R:R:W304	11.1017	6	3	9
60	R:R:F305	4.8925	4	8	8
61	R:R:Y310	7.29	4	15	8
62	R:R:W312	7.99	5	0	7
63	R:R:H313	6.84	4	0	7
64	R:R:W338	8.222	5	3	9
65	R:R:I340	3.0325	4	3	5
66	R:R:P341	4.128	5	3	9
67	R:R:L344	4.52	4	3	8
68	R:R:I348	10.7	4	3	7
69	R:R:Q353	8.05	4	16	7
70	R:R:D355	4.458	5	0	9
71	R:R:D357	9.078	5	2	8
72	R:R:V359	5.444	5	2	7
73	R:R:Y367	7.552	5	2	5
74	R:R:Y370	12.3525	4	2	4
75	R:R:R373	5.7025	4	2	9
76	R:R:F376	7.53	4	3	8
77	R:R:F391	8.3625	4	0	8
78	R:R:F428	4.756	5	0	8
79	R:R:Y445	5.58	4	2	8
80	R:R:D446	5.38	4	2	7
81	R:R:W453	11.032	5	2	9
82	R:R:F457	5.82	4	0	7
83	R:R:E464	7.79	4	0	4
84	R:R:I469	3.8275	4	4	4
85	R:R:N484	7.305	4	2	4
86	R:R:R485	5.595	4	2	7
87	R:R:P486	10.875	4	2	9
88	R:R:V490	4.3575	4	0	7
89	R:R:L495	3.665	4	7	8
90	R:R:F499	6.912	5	7	9
91	R:R:M505	4.91	4	8	9
92	R:R:S506	3.506	5	13	9
93	R:R:V509	5.89	4	0	8
94	W:W:?3	8.03286	7	1	0

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:Y367	22.8011	15.04	Yes	Yes	2	0	5
2	R:R:F364	R:R:Y367	53.1952	9.28	No	Yes	0	9	5
3	R:R:F364	R:R:Y295	53.3835	4.13	No	Yes	0	9	9
4	R:R:F291	R:R:Y295	97.7422	7.22	Yes	Yes	3	9	9
5	R:R:F291	R:R:V354	99.3857	13.11	Yes	No	0	9	8
6	R:R:E278	R:R:V354	99.4247	2.85	No	No	0	8	8
7	R:R:E278	R:R:T280	97.4597	5.64	No	No	0	8	7
8	R:R:K177	R:R:T280	48.1594	4.5	Yes	No	5	4	7
9	R:R:K177	R:R:N175	47.8048	9.79	Yes	Yes	5	4	6
10	R:R:N175	R:R:P176	100	4.89	Yes	No	0	6	3
11	R:R:P176	R:R:W179	99.6227	9.46	No	No	0	3	5
12	R:R:E184	R:R:W179	94.5999	2.18	No	No	0	5	5
13	R:R:E184	R:R:R96	93.8064	8.14	No	No	0	5	8
14	R:R:F160	R:R:R96	41.3092	17.1	Yes	No	0	8	8
15	R:R:C100	R:R:F160	25.9304	4.19	No	Yes	0	9	8
16	R:R:C100	R:R:V155	17.538	3.42	No	No	0	9	5
17	R:R:A101	R:R:V155	17.0497	3.39	No	No	0	8	5
18	R:R:A101	R:R:P115	16.5575	3.74	No	No	0	8	9
19	R:R:L65	R:R:P115	13.2996	3.28	No	No	0	8	9
20	R:R:L114	R:R:L65	12.7087	2.77	No	No	0	7	8
21	R:R:R269	R:R:T280	49.3172	5.17	Yes	No	5	7	7
22	R:R:N175	R:R:R269	51.0276	3.62	Yes	Yes	5	6	7
23	R:R:L46	R:R:L56	14.2198	5.54	No	Yes	0	7	7
24	R:R:F160	R:R:I158	14.7483	5.02	Yes	Yes	4	8	5
25	R:R:I158	R:R:P57	11.26	6.77	Yes	Yes	4	5	7
26	R:R:R96	R:R:W92	54.2472	23.99	No	Yes	0	8	9
27	R:R:I95	R:R:W92	50.2516	3.52	Yes	Yes	1	8	9
28	R:R:I95	R:R:W82	47.4068	3.52	Yes	Yes	1	8	7
29	R:R:W82	R:R:Y103	17.9653	7.72	Yes	Yes	1	7	7
30	R:R:E74	R:R:S69	12.345	4.31	No	Yes	1	5	7
31	R:R:W136	R:R:W82	16.914	3.75	Yes	Yes	1	9	7
32	R:R:R124	R:R:W136	15.3373	29.99	Yes	Yes	1	6	9
33	R:R:I482	R:R:L194	12.0444	2.85	No	Yes	0	4	6
34	R:R:E464	R:R:Y460	10.2353	8.98	Yes	No	0	4	5
35	R:R:M203	R:R:V359	11.4223	4.56	No	Yes	0	8	7
36	R:R:I207	R:R:M203	11.0658	2.92	No	No	0	7	8
37	R:R:D357	R:R:S360	14.6126	10.31	Yes	No	0	8	8
38	R:R:I362	R:R:S360	14.1788	7.74	No	No	0	9	8
39	R:R:I362	R:R:W254	12.558	7.05	No	Yes	0	9	7
40	R:R:F499	R:R:W254	15.8562	8.02	Yes	Yes	7	9	7
41	R:R:F499	R:R:S211	11.1255	6.61	Yes	No	0	9	7
42	R:R:F499	R:R:T214	12.0645	6.49	Yes	No	0	9	8
43	R:R:F248	R:R:I215	10.5736	7.54	Yes	Yes	12	6	5
44	R:R:T345	R:R:Y295	62.7149	6.24	No	Yes	0	9	9
45	R:R:T345	R:R:Y296	62.4636	3.75	No	Yes	0	9	8
46	R:R:W338	R:R:Y296	62.1856	7.72	Yes	Yes	0	9	8
47	R:R:W304	R:R:W338	45.8866	8.43	Yes	Yes	3	9	9
48	R:R:W304	R:R:Y242	21.7699	14.47	Yes	Yes	3	9	8
49	R:R:F241	R:R:Y242	35.3981	5.16	Yes	Yes	3	9	8
50	R:R:H334	R:R:W338	17.1003	12.7	No	Yes	3	9	9
51	R:R:H334	R:R:Y242	16.775	10.89	No	Yes	3	9	8
52	R:R:F248	R:R:L222	16.7575	3.65	Yes	No	0	6	7
53	R:R:F241	R:R:L222	17.3938	7.31	Yes	No	0	9	7
54	R:R:F225	R:R:F241	21.0556	7.5	Yes	Yes	0	9	9
55	R:R:I239	R:R:W304	23.7784	5.87	Yes	Yes	0	8	9
56	R:R:I239	R:R:P236	13.7457	3.39	Yes	No	0	8	9
57	R:R:P236	R:R:W312	12.5756	5.4	No	Yes	0	9	7
58	R:R:I239	R:R:L308	13.7457	4.28	Yes	No	0	8	8
59	R:R:L308	R:R:W312	12.5756	19.36	No	Yes	0	8	7
60	R:R:F428	R:R:W312	18.0231	5.01	Yes	Yes	0	8	7
61	R:R:F305	R:R:F428	13.2347	4.29	Yes	Yes	0	8	8
62	R:R:M307	R:R:W304	11.8593	4.65	No	Yes	0	7	9
63	R:R:H443	R:R:R373	10.7385	11.28	No	Yes	0	9	9
64	R:R:D357	R:R:Y367	16.2178	4.6	Yes	Yes	2	8	5
65	R:R:F225	R:R:V509	13.8087	5.24	Yes	Yes	0	9	8
66	R:R:R373	R:R:Y367	13.2171	3.09	Yes	Yes	2	9	5

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:?1	R:R:N192	12.11	2	Yes	Yes	0	7	0	1
L:L:?1	R:R:L194	5.55	2	Yes	Yes	0	6	0	1
L:L:?1	R:R:F195	2.93	2	Yes	Yes	0	6	0	1
L:L:?1	R:R:D357	16.33	2	Yes	Yes	0	8	0	1
L:L:?1	R:R:Y367	15.04	2	Yes	Yes	0	5	0	1
L:L:?1	R:R:K368	4.52	2	Yes	No	0	4	0	1
L:L:?1	R:R:R373	4.87	2	Yes	Yes	0	9	0	1
L:L:?1	R:R:Q450	8.54	2	Yes	No	0	7	0	1
L:L:?1	R:R:E454	3.19	2	Yes	No	0	5	0	1
L:L:?1	R:R:F457	5.86	2	Yes	Yes	0	7	0	1
L:L:?1	R:R:E491	9.56	2	Yes	No	0	6	0	1
R:R:F457	R:R:I188	3.77	0	Yes	No	7	6	1	2
R:R:N192	R:R:P193	6.52	2	Yes	Yes	7	8	1	2
R:R:L194	R:R:N192	5.49	2	Yes	Yes	6	7	1	1
R:R:F195	R:R:N192	8.46	2	Yes	Yes	6	7	1	1
R:R:D357	R:R:N192	5.39	2	Yes	Yes	8	7	1	1
R:R:N192	R:R:V359	4.43	2	Yes	Yes	7	7	1	2
R:R:F457	R:R:P193	5.78	0	Yes	Yes	7	8	1	2
R:R:F195	R:R:L194	4.87	2	Yes	Yes	6	6	1	1
R:R:I482	R:R:L194	2.85	0	No	Yes	4	6	2	1
R:R:L194	R:R:P486	4.93	2	Yes	Yes	6	9	1	2
R:R:E199	R:R:F195	5.83	2	Yes	Yes	8	6	2	1
R:R:F195	R:R:V359	3.93	2	Yes	Yes	6	7	1	2
R:R:F195	R:R:R485	5.34	2	Yes	Yes	6	7	1	2
R:R:F195	R:R:P486	8.67	2	Yes	Yes	6	9	1	2
R:R:F195	R:R:L488	8.53	2	Yes	No	6	6	1	2
R:R:E199	R:R:R485	9.3	2	Yes	Yes	8	7	2	2
R:R:E199	R:R:L488	7.95	2	Yes	No	8	6	2	2
R:R:D355	R:R:Y367	5.75	0	Yes	Yes	9	5	2	1
R:R:D355	R:R:K368	4.15	0	Yes	No	9	4	2	1
R:R:D357	R:R:V359	8.76	2	Yes	Yes	8	7	1	2
R:R:D357	R:R:S360	10.31	2	Yes	No	8	8	1	2
R:R:D357	R:R:Y367	4.6	2	Yes	Yes	8	5	1	1
R:R:F364	R:R:Y367	9.28	0	No	Yes	9	5	2	1
R:R:R373	R:R:Y367	3.09	2	Yes	Yes	9	5	1	1
R:R:K368	R:R:N369	13.99	0	No	No	4	8	1	2
R:R:Q450	R:R:Y370	20.29	2	No	Yes	7	4	1	2
R:R:H443	R:R:R373	11.28	0	No	Yes	9	9	2	1
R:R:D446	R:R:R373	3.57	2	Yes	Yes	7	9	2	1
R:R:D446	R:R:E491	7.8	2	Yes	No	7	6	2	1
R:R:E454	R:R:Q450	3.82	2	No	No	5	7	1	1
R:R:F457	R:R:V461	7.87	0	Yes	No	7	6	1	2
R:R:P486	R:R:R485	2.88	2	Yes	Yes	9	7	2	2
R:R:L488	R:R:R485	4.86	2	No	Yes	6	7	2	2
R:R:E491	R:R:V490	2.85	0	No	Yes	6	7	1	2

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

Similarity	Network Type	Name	Ligand	Description
60.00	Single	4QIN	SAG1.5	4QIN-SMO-SAG1.5
60.00	Single	6O3C	SAG21k	6O3C-SMO-SAG21k-Cholesterol
54.55	Single	7ZI0	SAG	7ZI0-SMO-SAG-Cholesterol
50.00	Single	4O9R	Cyclopamine	4O9R-SMO-Cyclopamine
50.00	Single	4QIM	ANTA XV	4QIM-SMO-ANTA XV
46.15	Single	4JKV	Taladegib	4JKV-SMO-Taladegib
44.44	Single	6XBM	5LWE	6XBM-SMO-5LWE-Gi1/β1/γ2
42.86	Single	5V56	TC114	5V56-SMO-TC114
42.86	Single	5V57	TC114	5V57-SMO-TC114
41.67	Single	6XBL	SAG	6XBL-SMO-SAG-Cholesterol-Gi1/β1/γ2
38.46	Single	8IC0	Interleukin-8	8IC0-CXCR1-Interleukin-8-Gi1/β1/γ2
38.46	Consensus	cxcr1_on_gp	Orthosteric Ligand	8IC0-CXCR1-Interleukin-8-Gi1/β1/γ2
33.33	Single	8XXX	CXCL6	8XXX-CXCR2-CXCL6-Go/β1/γ2
33.33	Consensus	cxcr1_on	Orthosteric Ligand	8IC0-CXCR1-Interleukin-8-Gi1/β1/γ2
31.25	Single	8XX3	CXCL3	8XX3-CXCR2-CXCL3-Go/β1/γ2
30.00	Consensus	p2y_off	Orthosteric Ligand	p2y1_off
29.41	Single	8XWF	CXCL3	8XWF-CXCR2-CXCL3
28.57	Single	6XBM	5LWE	6XBM-SMO-5LWE-Gi1/β1/γ2
27.78	Single	8XX6	CXCL8	8XX6-CXCR2-CXCL8-Go/β1/γ2
27.27	Single	4XNW	MRS2500	4XNW-P2Y₁-MRS2500
27.27	Single	8JEF	(3S)-3-hydroxyoctanoic acid	8JEF-HCA₃-(3S)-3-hydroxyoctanoic acid-Gi1/β1/γ2
27.27	Consensus	p2y1_off	Orthosteric Ligand	4XNW-P2Y₁-MRS2500
26.67	Single	6XBK	Cholesterol	6XBK-SMO-Cholesterol-Gi1/β1/γ2
26.67	Single	7YU3	ONO-0740556	7YU3-LPA₁-ONO-0740556-Gi1/β1/γ2
26.32	Single	8XWN	CXCL8	8XWN-CXCR2-CXCL8
25.00	Single	5L7I	Vismodegib	5L7I-SMO-Vismodegib
25.00	Single	6LI0	C17	6LI0-GPR52-C17
25.00	Single	7VDH	C48/80	7VDH-MRGPRX2-C48/80-Gi1/β1/γ2
25.00	Single	7YU5	ONO-0740556	7YU5-LPA₁-ONO-0740556-Gi1/β1/γ2
25.00	Single	7YU7	ONO-0740556	7YU7-LPA₁-ONO-0740556-Gi1/β1/γ2
25.00	Single	8XX7	CXCL5	8XX7-CXCR2-CXCL5-Go/β1/γ2
25.00	Consensus	gi_lpa	Orthosteric Ligand	7TD1-LPA₁-LPA-Gi1/β1/γ2 7YU3-LPA₁-ONO-0740556-Gi1/β1/γ2
25.00	Consensus	lpa_on	Orthosteric Ligand	lpa1_on
25.00	Consensus	lpa_on_gp	Orthosteric Ligand	lpa1_on_gp
23.81	Single	3OE0	CVX15	3OE0-CXCR4-CVX15
23.53	Single	8XWA	CXCL1	8XWA-CXCR2-CXCL1
23.53	Single	8XWM	CXCL6	8XWM-CXCR2-CXCL6
23.53	Single	8XWS	CXCL5	8XWS-CXCR2-CXCL5
23.53	Consensus	cxcr_on	Orthosteric Ligand	cxcr3_on cxcr4_on cxcr1_on cxcr2_on
23.53	Consensus	gi_lipid	Orthosteric Ligand	gi_cannabinoid gi_ffa gi_leukotriene gi_lpa gi_s1p
23.08	Single	3PWH	ZM-241385	3PWH-A_2A-ZM-241385
23.08	Single	6LFO	Interleukin-8	6LFO-CXCR2-Interleukin-8-Gi1/β1/γ2
23.08	Single	7VV5	C48/80	7VV5-MRGPRX2-C48/80-Gi1/β1/γ2
23.08	Single	8HMP	C17	8HMP-GPR52-C17-Gs/β1/γ2
23.08	Consensus	p2y1_on	Orthosteric Ligand	7XXH-P2Y₁-2MeSADP-chim(NtGi1-G11)/β1/γ2
22.22	Single	4RWS	vMIP-II	4RWS-CXCR4-vMIP-II
22.22	Single	7YU8	ONO-0740556	7YU8-LPA₁-ONO-0740556-Gi1/β1/γ2
22.22	Single	8K4O	CXCL1	8K4O-KSHV-CXCL1-Gi1/β1/γ1
22.22	Single	8XVU	CXCL2	8XVU-CXCR2-CXCL2
22.22	Single	8XWV	CXCL1	8XWV-CXCR2-CXCL1-Go/β1/γ2
22.22	Single	8XXH	CXCL2	8XXH-CXCR2-CXCL2-Go/β1/γ2
22.22	Single	8ZPL	HF51116	8ZPL-CXCR4-HF51116
21.74	Single	7F6H	Bradykinin	7F6H-BK₂-Bradykinin-Gq/β1/γ2
21.74	Single	7F6I	Kallidin	7F6I-BK₂-Kallidin-Gq/β1/γ2
21.74	Consensus	cxcr_off	Orthosteric Ligand	cxcr3_off cxcr4_off
21.43	Single	5IU4	ZM-241385	5IU4-A_2A-ZM-241385-Na
21.43	Single	5IUB	Q27456344	5IUB-A_2A-Q27456344-Na
21.43	Single	5K2C	ZM-241385	5K2C-A_2A-ZM-241385-Na
21.43	Single	5NM4	ZM-241385	5NM4-A_2A-ZM-241385-Na
21.43	Single	6AQF	ZM-241385	6AQF-A_2A-ZM-241385
21.43	Single	7ARO	LUF5833	7ARO-A_2A-LUF5833-Na
21.43	Single	7VV6	C48/80	7VV6-MRGPRX2-C48/80
21.43	Single	7XXH	2MeSADP	7XXH-P2Y₁-2MeSADP-chim(NtGi1-G11)/β1/γ2
21.43	Single	9BA0	A1AKN	9BA0-CB₁-A1AKN
21.43	Single	9K0K	UTP	9K0K-P2Y₄-UTP-chim(NtGi1-Gs-CtGq)/β1/γ2
21.43	Single	9K0X	ATP	9K0X-P2Y₂-ATP-chim(NtGi1-Gs-CtGq)/β1/γ2
21.43	Single	9K20	ATP	9K20-P2Y₂-ATP-chim(NtGi1-Go)/β1/γ2
21.43	Consensus	nucleotide_off	Orthosteric Ligand	adenosine_off p2y_off
21.43	Consensus	p2y1_on_gp	Orthosteric Ligand	7XXH-P2Y₁-2MeSADP-chim(NtGi1-G11)/β1/γ2
21.05	Single	7RKN	Fractalkine	7RKN-US28-Fractalkine-Gi1/β1/γ2
21.05	Consensus	cxcr4_off	Orthosteric Ligand	4RWS-CXCR4-vMIP-II 3OE0-CXCR4-CVX15 3OE6-CXCR4-IT1t
21.05	Consensus	cxcr_on_gp	Orthosteric Ligand	cxcr3_on_gp cxcr4_on_gp cxcr1_on_gp cxcr2_on_gp
20.00	Single	4EIY	ZM-241385	4EIY-A_2A-ZM-241385-Na
20.00	Single	5IU8	Q27456347	5IU8-A_2A-Q27456347-Na
20.00	Single	5OLG	ZM-241385	5OLG-A_2A-ZM-241385-Na
20.00	Single	5UEN	DU172	5UEN-A₁-DU172
20.00	Single	6LPJ	ZM-241385	6LPJ-A_2A-ZM-241385-Na
20.00	Single	6LPK	ZM-241385	6LPK-A_2A-ZM-241385-Na
20.00	Single	7CFM	P395	7CFM-GPBA-P395-Gs/β1/γ2
20.00	Single	7FIH	Org43553	7FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/β1/γ2
20.00	Single	7PYR	PSB-2115	7PYR-A_2A-PSB-2115
20.00	Single	7SK8	CXCL12	7SK8-ACKR3-CXCL12-CCX662
20.00	Single	7VLA	CCL15(27-92)	7VLA-CCR1-CCL15(27-92)-Gi1/β1/γ2
20.00	Single	7W2Z	Ghrelin	7W2Z-Ghrelin-Ghrelin-Go/β1/γ2
20.00	Single	7YU4	ONO-0740556	7YU4-LPA₁-ONO-0740556
20.00	Single	8K3Z	CXCL12	8K3Z-CXCR4-CXCL12-Gi1/β1/γ1
20.00	Single	8RW7	StilSwitch1	8RW7-A_2A-StilSwitch1-Na
20.00	Single	8TH3	AT118-H Nanobody	8TH3-AT₁-AT118-H Nanobody
20.00	Single	8U4O	CXCL12	8U4O-CXCR4-CXCL12-Gi1/β1/γ2
20.00	Consensus	ccr1_on	Orthosteric Ligand	7VLA-CCR1-CCL15(27-92)-Gi1/β1/γ2
20.00	Consensus	ccr1_on_gp	Orthosteric Ligand	7VLA-CCR1-CCL15(27-92)-Gi1/β1/γ2
20.00	Consensus	chemokine_on	Orthosteric Ligand	ccr_on cxcr_on
20.00	Consensus	cxcr4_on	Orthosteric Ligand	8K3Z-CXCR4-CXCL12-Gi1/β1/γ1
20.00	Consensus	nucleotide_offon	Orthosteric Ligand	nucleotide_off nucleotide_on
20.00	Consensus	nucleotide_offon_gp	Orthosteric Ligand	nucleotide_on_gp nucleotide_off
19.23	Consensus	bk2_on	Orthosteric Ligand	7F6H-BK₂-Bradykinin-Gq/β1/γ2 7F6I-BK₂-Kallidin-Gq/β1/γ2
19.23	Consensus	bk2_on_gp	Orthosteric Ligand	7F6H-BK₂-Bradykinin-Gq/β1/γ2 7F6I-BK₂-Kallidin-Gq/β1/γ2
19.23	Consensus	bradykinin_on	Orthosteric Ligand	bk2_on
19.23	Consensus	bradykinin_on_gp	Orthosteric Ligand	bk2_on_gp
19.23	Consensus	gq_bradykinin	Orthosteric Ligand	7F6H-BK₂-Bradykinin-Gq/β1/γ2 7F6I-BK₂-Kallidin-Gq/β1/γ2
19.05	Single	7C6A	(Sar1,Ile8)-Angiotensin II	7C6A-AT₂-(Sar1,Ile8)-Angiotensin II
19.05	Single	9J0F	NADH	9J0F-P2Y₁₄-NADH-Gi1/β1/γ2
18.75	Single	5IUA	Q27456348	5IUA-A_2A-Q27456348-Na
18.75	Single	5NM2	ZM-241385	5NM2-A_2A-ZM-241385-Na
18.75	Single	6LFM	Interleukin-8	6LFM-CXCR2-Interleukin-8-Gi1/β1/γ2
18.75	Single	6LPL	ZM-241385	6LPL-A_2A-ZM-241385-Na
18.75	Single	6S0Q	ZM-241385	6S0Q-A_2A-ZM-241385
18.75	Single	6WQA	ZM-241385	6WQA-A_2A-ZM-241385-Na
18.75	Single	7RM5	ZM-241385	7RM5-A_2A-ZM-241385-Na
18.75	Single	7YU6	ONO-0740556	7YU6-LPA₁-ONO-0740556-Gi1/β1/γ2
18.75	Single	8FYN	ZM-241385	8FYN-A_2A-ZM-241385-Na
18.75	Single	8TH4	AT118-L Nanobody	8TH4-AT₁-Losartan-AT118-L Nanobody
18.75	Single	8WGB	VU0155041	8WGB-mGlu4; mGlu2-Glutammate-VU0155041-Gi3/β1/γ2
18.75	Single	9B9Z	A1AKO	9B9Z-CB₁-A1AKO
18.75	Single	9EAH	Nanobody AT209	9EAH-AT₁-Olmesartan-Nanobody AT209
18.75	Consensus	a1_off	Orthosteric Ligand	5UEN-A₁-DU172 5N2S-A₁-PSB36
18.75	Consensus	adenosine_off	Orthosteric Ligand	a1_off a2_off
18.75	Consensus	cxcr2_on_gp	Orthosteric Ligand	6LFM-CXCR2-Interleukin-8-Gi1/β1/γ2
18.75	Consensus	lipid_on	Orthosteric Ligand	cannabinoid_on ffa_on lpl_on prostanoid_on leukotriene_on
18.75	Consensus	lipid_on_gp	Orthosteric Ligand	cannabinoid_on_gp ffa_on_gp lpl_on_gp prostanoid_on_gp leukotriene_on_gp
18.75	Consensus	lpa1_on	Orthosteric Ligand	7TD1-LPA₁-LPA-Gi1/β1/γ2 7YU3-LPA₁-ONO-0740556-Gi1/β1/γ2
18.75	Consensus	lpa1_on_gp	Orthosteric Ligand	7TD1-LPA₁-LPA-Gi1/β1/γ2 7YU3-LPA₁-ONO-0740556-Gi1/β1/γ2
18.75	Consensus	nucleotide_on	Orthosteric Ligand	adenosine_on p2y_on
18.75	Consensus	s1p5_off	Orthosteric Ligand	7YXA-S1P₅-ONO-5430608
18.75	Consensus	s1p_off	Orthosteric Ligand	s1p1_off s1p5_off
18.18	Single	6OT0	25(S)-Epoxycholesterol	6OT0-SMO-25(S)-Epoxycholesterol-Gi1/β1/γ2
18.18	Single	7O7F	6P4-CCL5	7O7F-CCR5-6P4-CCL5-Gi1/β1/γ1
18.18	Single	7TD2	LPA	7TD2-LPA₁-LPA-Gi1/β1/γ2
18.18	Single	8U4Q	REGN7663-Fab	8U4Q-CXCR4-REGN7663-Fab-Gi1/β1/γ2
18.18	Consensus	cxcr4_on_gp	Orthosteric Ligand	8K3Z-CXCR4-CXCL12-Gi1/β1/γ1
17.86	Single	7SK6	CXCL12_LRHQ	7SK6-ACKR3-CXCL12_LRHQ
17.65	Single	6OS1	TRV026	6OS1-AT₁-TRV026
17.65	Single	7F1T	MIP-1a	7F1T-CCR5-MIP-1a
17.65	Single	7F58	THIQ	7F58-MC₄-THIQ-Gs/β1/γ2
17.65	Single	7PX4	PSB-2113	7PX4-A_2A-PSB-2113
17.65	Single	7SK7	CXCL12	7SK7-ACKR3-CXCL12-CCX662
17.65	Single	7TD1	LPA	7TD1-LPA₁-LPA-Gi1/β1/γ2
17.65	Single	7TUY	GSK682753A	7TUY-GPR183-GSK682753A
17.65	Single	7XTQ	R399	7XTQ-GPBA-R399-Gs/β1/γ2
17.65	Single	8FMZ	Neurotensin/Neuromedin-N	8FMZ-NTS₁-Neurotensin/Neuromedin-N-chim(NtGi2L-Gs-CtGq)/β1/γ2
17.65	Single	8HQC	C5a anaphylatoxin	8HQC-C5a₁-C5a anaphylatoxin-Go/β1/γ2
17.65	Single	8ID3	9-Hydroxystearic acid	8ID3-FFA4-9-Hydroxystearic acid-Gi1/β1/γ2
17.65	Single	8ID6	Oleic acid	8ID6-FFA4-Oleic acid-Gi1/β1/γ2
17.65	Single	8WJX	ADP	8WJX-P2Y₁-ADP-chim(Gs-CtGq)/β1/γ2
17.65	Single	9ITE	LPA	9ITE-LPA₆-LPA-chim(NtGi2-G13)/β1/γ2
17.65	Single	9IZG	NKP	9IZG-LPA₁-NKP-chim(NtGi1-Gs-CtGq)/β1/γ2
17.65	Consensus	class-a_off	Orthosteric Ligand	sensory_off alicarboxylic_off amine_off lipid_off nucleotide_off peptide_off protein_off
17.65	Consensus	protein_off	Orthosteric Ligand	chemokine_off grh_off
17.39	Single	5WB2	CX3CL1.35	5WB2-US28-CX3CL1.35
17.39	Consensus	protein_offon	Orthosteric Ligand	protein_off protein_on
17.39	Consensus	protein_offon_gp	Orthosteric Ligand	protein_on_gp protein_off
16.67	Single	4PXZ	2MeSADP	4PXZ-P2Y₁₂-2MeSADP
16.67	Single	4PY0	2MeSATP	4PY0-P2Y₁₂-2MeSATP
16.67	Single	6OS2	TRV026	6OS2-AT₁-TRV026
16.67	Single	7L0S	Neurotensin	7L0S-NTS₁-Neurotensin-Gi1/β1/γ1
16.67	Single	7XW5	ML109	7XW5-TSH-TSH-ML109-Gs/β1/γ2
16.67	Single	8DWC	Proenkephalin-A	8DWC-MRGPRX1-Proenkephalin-A-chim(NtGi2L-Gs-CtGq)/β1/γ2
16.67	Single	8F76	Propanoic acid	8F76-OR51E2-Propanoic acid-Gs/β1/γ2
16.67	Single	8HNK	CXCL11	8HNK-CXCR3-CXCL11-Gi1/β1/γ2
16.67	Single	8J6Q	Compound 9n	8J6Q-HCA₂-β-Hydroxybutyrate-Compound 9n-Gi1/β1/γ2
16.67	Single	8JPB	Neurotensin-(8-13)	8JPB-NTS₁-Neurotensin-(8-13)-SBI-553; GDP; Mg-Gq; GRK2
16.67	Single	8JPS	CCL7	8JPS-ACKR1-CCL7
16.67	Single	8JWY	2-118	8JWY-A_2A-2-118
16.67	Single	8T3Q	Docosa-4,7,10,13,16,19-Hexaenoic acid	8T3Q-FFA4-Docosa-4,7,10,13,16,19-Hexaenoic acid-chim(NtGi2L-Gs-CtGq)/β1/γ2
16.67	Single	8XVH	Endothelin-1	8XVH-ET_B-Endothelin-1-chim(Gs-CtGq)/β1/γ2
16.67	Single	8XVI	Endothelin-1	8XVI-ET_A-Endothelin-1-chim(Gs-CtGq)/β1/γ2
16.67	Single	9IZH	LPA	9IZH-LPA₁-LPA-chim(NtGi2-G13)/β1/γ2
16.67	Consensus	chemokine_off	Orthosteric Ligand	ccr_off cxcr_off
16.67	Consensus	chemokine_on_gp	Orthosteric Ligand	ccr_on_gp cxcr_on_gp
16.67	Consensus	gi_chemokine	Orthosteric Ligand	6WWZ-CCR6-CCL20-Go/β1/γ2 8HNK-CXCR3-CXCL11-Gi1/β1/γ2 8K3Z-CXCR4-CXCL12-Gi1/β1/γ1 8IC0-CXCR1-Interleukin-8-Gi1/β1/γ2 6LFM-CXCR2-Interleukin-8-Gi1/β1/γ2 8KFX-CCR8-LMD-009-Gi1/β1/γ2 7F1Q-CCR5-MIP-1a-Gi1/β1/γ2 8HNL-CXCR3-PS372424-Gi1/β1/γ2 8KFY-CCR8-ZK-756326-Gi1/β1/γ2 7O7F-CCR5-6P4-CCL5-Gi1/β1/γ1 8U1U-CCR8-CCL1-Gi1/β1/γ2 7VLA-CCR1-CCL15(27-92)-Gi1/β1/γ2 7XA3-CCR2-CCL2-Gi1/β1/γ2
16.67	Consensus	lipid_offon	Orthosteric Ligand	lipid_off lipid_on
16.67	Consensus	lipid_offon_gp	Orthosteric Ligand	lipid_on_gp lipid_off
16.67	Consensus	lpa1_off	Orthosteric Ligand	4Z36-LPA₁-ONO-3080573 4Z35-LPA₁-ONO-9910539 4Z34-LPA₁-ONO-9780307
16.67	Consensus	lpa_off	Orthosteric Ligand	lpa1_off
16.67	Consensus	lpl_off	Orthosteric Ligand	s1p_off lpa_off
16.00	Single	5UIW	5P7-CCL5	5UIW-CCR5-5P7-CCL5
16.00	Single	7SK3	CXCL12	7SK3-ACKR3-CXCL12
16.00	Single	7SK4	CXCL12_LRHQ	7SK4-ACKR3-CXCL12_LRHQ
16.00	Single	8XQF	Apelin-13	8XQF-Apelin-Apelin-13-Gi1/β1/γ2
16.00	Consensus	ccr5_off	Orthosteric Ligand	5UIW-CCR5-5P7-CCL5
16.00	Consensus	ccr5_on	Orthosteric Ligand	7O7F-CCR5-6P4-CCL5-Gi1/β1/γ1 7F1Q-CCR5-MIP-1a-Gi1/β1/γ2
16.00	Consensus	ccr_off	Orthosteric Ligand	ccr2_off ccr5_off
15.79	Single	4Z35	ONO-9910539	4Z35-LPA₁-ONO-9910539
15.79	Single	6UP7	Neurotensin	6UP7-NTS₁-Neurotensin-Arrestin2
15.79	Single	7EW0	Ozanimod	7EW0-S1P₁-Ozanimod-Gi1/β1/γ2
15.79	Single	7XK2	MK6892	7XK2-HCA₂-MK6892-Gi1/β1/γ2
15.79	Single	8IYS	TUG-891	8IYS-FFA4-TUG-891-GDP-chim(NtGi1L-Gq)/β1/γ2
15.79	Single	8JPF	Neurotensin	8JPF-NTS₁-Neurotensin-SBI-553
15.79	Single	8WRZ	PubChem 102336704	8WRZ-CB₁-PubChem 102336704-Arrestin2
15.79	Single	8XBE	S3E-LysoPS	8XBE-GPR34-S3E-LysoPS-Gi1/β1/γ1
15.79	Single	8ZX4	Lysophosphatidylinositol	8ZX4-GPR55-Lysophosphatidylinositol-chim(NtGi1-G13)/β1/γ2
15.79	Single	9GE3	Lysophosphatidylinositol	9GE3-GPR55-Lysophosphatidylinositol-chim(NtGi1-G13)/β1/γ2
15.79	Single	9IZF	NKP	9IZF-LPA₁-NKP-Gi1/β1/γ2
15.79	Consensus	nucleotide_on_gp	Orthosteric Ligand	adenosine_on_gp p2y_on_gp
15.38	Single	6PH7	Nerol	6PH7-Rhodopsin-Nerol-Gt(CT)
15.38	Single	6QNO	All-trans-Retinal	6QNO-Rhodopsin-All-trans-Retinal-Gi1/β1/γ1
15.38	Single	7S8N	R-Zinc-3573	7S8N-MRGPRX2-R-Zinc-3573-chim(NtGi2L-Gs-CtGq)/β1/γ2
15.38	Single	7S8O	R-Zinc-3573	7S8O-MRGPRX2-R-Zinc-3573-Gi1/β1/γ2
15.38	Single	7T96	LY2119620	7T96-M₂-Acetylcholine-LY2119620-Go/β1/γ2
15.38	Single	8FX5	Xanomeline	8FX5-M₄-Xanomeline-Xanomeline-Gi1/β1/γ2
15.38	Single	8IHI	Acifran	8IHI-HCA₂-Acifran-Gi1/β1/γ2
15.38	Single	8J6P	Compound 9n	8J6P-HCA₂-Niacin-Compound 9n-Gi1/β1/γ2
15.38	Single	8JHY	Compound 9n	8JHY-HCA₂-Compound 9n-Gi1/β1/γ2
15.38	Single	8JII	Compound 9n	8JII-HCA₂-Niacin-Compound 9n-Gi1/β1/γ2
15.38	Single	8JIL	Niacin	8JIL-HCA₂-Niacin-Gi1/β1/γ2
15.38	Single	8RWH	StilSwitch2	8RWH-A_2A-StilSwitch2-Na
15.38	Single	8U4R	REGN7663-Fab	8U4R-CXCR4-REGN7663-Fab
15.38	Single	8ZX5	AM251	8ZX5-GPR55-AM251-chim(NtGi1-G13)/β1/γ2
15.38	Single	8ZYU	Neurotensin peptide 8-13	8ZYU-NTS₁-Neurotensin peptide 8-13-SBI-553-Arrestin2
15.38	Single	9B9Y	7DY	9B9Y-CB₁-7DY
15.38	Single	9E7R	GB88	9E7R-PAR2-GB88-chim(NtGi1L-Gs-CtGq)/β1/γ2
15.38	Single	9KDF	RES-701-3	9KDF-ET_B-RES-701-3
15.38	Single	9LMP	NE52-QQ57	9LMP-GPR4-NE52-QQ57
15.38	Consensus	adgrg_on	Orthosteric Ligand	adgrg2_on adgrg4_on
15.38	Consensus	adgrg_on_gp	Orthosteric Ligand	adgrg2_on_gp adgrg4_on_gp
15.38	Consensus	gq_nucleotide	Orthosteric Ligand	gq_p2y
15.38	Consensus	gq_p2y	Orthosteric Ligand	7XXH-P2Y₁-2MeSADP-chim(NtGi1-G11)/β1/γ2
15.00	Single	5VBL	Apelin mimetic peptide agonist	5VBL-Apelin-Apelin mimetic peptide agonist
15.00	Single	6KNM	JN241-9	6KNM-Apelin-JN241-9
15.00	Single	6OS9	JMV449	6OS9-NTS₁-JMV449-Gi1/β1/γ2
15.00	Single	7RKF	Fractalkine	7RKF-US28-Fractalkine-GDP-chim(NtGi1-G11)/β1/γ2
15.00	Single	7XBX	CX3CL1	7XBX-CX3CR1-CX3CL1-Gi1/β1/γ2
15.00	Single	7XY6	BAY 60-6583	7XY6-A_2B-BAY 60-6583-chim(NtGi1-Gs)/β1/γ2
15.00	Single	8H4I	Doconexent	8H4I-FFA4-Doconexent-chim(NtGi1-Gs)/β1/γ2
15.00	Single	8JBF	Senktide	8JBF-NK₃-Senktide-chim(NtGi1-Gs-CtGq)/β1/γ2
15.00	Single	8QJ2	pN162	8QJ2-MC₄-pN162-Gs
15.00	Single	8XZF	WN561	8XZF-Apelin-WN561-Gi1/β1/γ2
15.00	Single	9EAJ	Nanobody AT209	9EAJ-AT₁-Nanobody AT209
15.00	Single	9IZA	SCH900271	9IZA-HCA₂-SCH900271-Gi1/β1/γ2
15.00	Consensus	cxcr3_on	Orthosteric Ligand	8HNK-CXCR3-CXCL11-Gi1/β1/γ2 8HNL-CXCR3-PS372424-Gi1/β1/γ2
14.81	Single	8IY5	Endothelin-1	8IY5-ET_B-Endothelin-1-Gi1/β1/γ2
14.81	Single	8IY6	Endothelin-1	8IY6-ET_B-Endothelin-1
14.81	Consensus	endothelin_on	Orthosteric Ligand	etb_on eta_on
14.81	Consensus	gs_melanocortin	Orthosteric Ligand	7F4H-MC₁-Afamelanotide-chim(NtGi1-Gs)/β1/γ2 7F54-MC₄-Afamelanotide-Gs/β1/γ2 7F4D-MC₁-α-MSH-chim(NtGi1-Gs)/β1/γ2 8INR-MC₅-α-MSH-Ca-chim(NtGi1-Gs)/β1/γ2 7F53-MC₄-α-MSH-Gs/β1/γ2 7F55-MC₄-Bremelanotide-Gs/β1/γ2 8GY7-MC₂-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1 8IOC-MC₃-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2 8IOD-MC₅-PG-901-Ca-chim(NtGi1-Gs)/β1/γ2 7AUE-MC₄-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2 7F4I-MC₁-SHU9119-chim(NtGi1-Gs)/β1/γ2 7F58-MC₄-THIQ-Gs/β1/γ2
14.29	Single	3V2W	PubChem 51892645	3V2W-S1P₁-PubChem 51892645
14.29	Single	3VG9	ZM-241385	3VG9-A_2A-ZM-241385-Antibody
14.29	Single	3VGA	ZM-241385	3VGA-A_2A-ZM-241385-Antibody
14.29	Single	4BWB	Neurotensin	4BWB-NTS₁-Neurotensin
14.29	Single	5GLH	Endothelin-1	5GLH-ET_B-Endothelin-1
14.29	Single	5K2D	ZM-241385	5K2D-A_2A-ZM-241385-Na
14.29	Single	5OLH	Vipadenant	5OLH-A_2A-Vipadenant-Na
14.29	Single	5U09	Taranabant	5U09-CB₁-Taranabant
14.29	Single	5ZKQ	ABT-491	5ZKQ-PAF-ABT-491
14.29	Single	6D32	Cyclopamine	6D32-SMO-Cyclopamine-Cyclopamine
14.29	Single	6D35	Cholesterol	6D35-SMO-Cholesterol
14.29	Single	6D9H	Adenosine	6D9H-A₁-Adenosine-Gi2/β1/γ2
14.29	Single	6FKB	PubChem 132473038	6FKB-Rhodopsin-PubChem 132473038
14.29	Single	6IGK	Endothelin-3	6IGK-ET_B-Endothelin-3
14.29	Single	6JZH	ZM-241385	6JZH-A_2A-ZM-241385-Na
14.29	Single	6N51	Quisqualate	6N51-mGlu5; mGlu5-Quisqualate
14.29	Single	6N51	Quisqualate	6N51-mGlu5; mGlu5-Quisqualate
14.29	Single	6PS7	ZM-241385	6PS7-A_2A-ZM-241385-Na
14.29	Single	6UO8	SKF97541	6UO8-GABA_B1, GABA_B2-SKF97541-GS39783
14.29	Single	6UO9	SKF97541	6UO9-GABA_B1, GABA_B2-SKF97541
14.29	Single	6W2X	PubChem 5311042	6W2X-GABA_B1, GABA_B2-PubChem 5311042
14.29	Single	6W2Y	PubChem 5311042	6W2Y-GABAB1; GABAB1-PubChem 5311042
14.29	Single	6W2Y	PubChem 5311042	6W2Y-GABAB1; GABAB1-PubChem 5311042
14.29	Single	6WWZ	CCL20	6WWZ-CCR6-CCL20-Go/β1/γ2
14.29	Single	7C7Q	Baclofen	7C7Q-GABA_B1, GABA_B2-Baclofen-BHFF
14.29	Single	7C7S	CGP54626	7C7S-GABA_B1, GABA_B2-CGP54626
14.29	Single	7CUM	CGP54626	7CUM-GABA_B1, GABA_B2-CGP54626
14.29	Single	7DD5	Ca	7DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
14.29	Single	7DD5	Ca; Ca; Tryptophan; NPS-2143	7DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
14.29	Single	7DD5	Ca	7DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
14.29	Single	7DD5	Ca; Ca; Tryptophan; NPS-2143	7DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
14.29	Single	7DGE	Quisqualate	7DGE-mGlu1; mGlu1-Quisqualate
14.29	Single	7DTT	Ca	7DTT-CaS-Ca-Ca
14.29	Single	7DTT	Ca	7DTT-CaS-Ca-Ca
14.29	Single	7DTU	Tryptophan	7DTU-CaS-Tryptophan
14.29	Single	7DTU	Tryptophan	7DTU-CaS-Tryptophan
14.29	Single	7DTV	Ca	7DTV-CaS-Ca-Ca; Tryptophan
14.29	Single	7DTV	Ca; Tryptophan	7DTV-CaS-Ca-Ca; Tryptophan
14.29	Single	7DTV	Ca	7DTV-CaS-Ca-Ca; Tryptophan
14.29	Single	7DTV	Ca; Tryptophan	7DTV-CaS-Ca-Ca; Tryptophan
14.29	Single	7E6T	Ca	7E6T-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
14.29	Single	7E6T	Ca; Ca; Cyclomethyltryptophan; PO4	7E6T-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
14.29	Single	7E6T	Ca	7E6T-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
14.29	Single	7E6T	Ca; Ca; Cyclomethyltryptophan; PO4	7E6T-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
14.29	Single	7E9G	Eglumetad	7E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/β1/γ2
14.29	Single	7E9G	Eglumetad	7E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/β1/γ2
14.29	Single	7E9H	Phosphoserine	7E9H-mGlu4; mGlu4-Phosphoserine-Gi3/β1/γ2
14.29	Single	7E9H	Phosphoserine	7E9H-mGlu4; mGlu4-Phosphoserine-Gi3/β1/γ2
14.29	Single	7EB2	Baclofen	7EB2-GABAB2; GABAB1-Baclofen-rac-BHFF-Gi1/β1/γ2
14.29	Single	7EPB	Eglumetad	7EPB-mGlu2; mGlu2-Eglumetad
14.29	Single	7EPB	Eglumetad	7EPB-mGlu2; mGlu2-Eglumetad
14.29	Single	7F54	Afamelanotide	7F54-MC₄-Afamelanotide-Gs/β1/γ2
14.29	Single	7FD8	Quisqualate	7FD8-mGlu5; mGlu5-Quisqualate
14.29	Single	7FD8	Quisqualate	7FD8-mGlu5; mGlu5-Quisqualate
14.29	Single	7FD9	LY341495	7FD9-mGlu5; mGlu5-LY341495
14.29	Single	7FD9	LY341495	7FD9-mGlu5; mGlu5-LY341495
14.29	Single	7FIH	hCG	7FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/β1/γ2
14.29	Single	7FII	hCG	7FII-LH-hCG-chim(NtGi1-Gs)/β1/γ2
14.29	Single	7L0R	Neurotensin	7L0R-NTS₁-Neurotensin-Gi1/β1/γ1
14.29	Single	7M3E	Ca; Ca; Tryptophan; NPS-2143	7M3E-CaS-Ca; Ca; Tryptophan; NPS-2143
14.29	Single	7M3E	Ca; Ca; Tryptophan; NPS-2143	7M3E-CaS-Ca; Ca; Tryptophan; NPS-2143
14.29	Single	7M3F	Ca; Ca; Tryptophan; Cinacalcet; PO4	7M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
14.29	Single	7M3F	Ca; Ca; Tryptophan; Cinacalcet; PO4	7M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
14.29	Single	7M3G	Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4	7M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
14.29	Single	7M3G	Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4	7M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
14.29	Single	7M3G	Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4	7M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
14.29	Single	7M3G	Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4	7M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
14.29	Single	7MTQ	LY341495	7MTQ-mGlu2; mGlu2-LY341495
14.29	Single	7MTQ	LY341495	7MTQ-mGlu2; mGlu2-LY341495
14.29	Single	7MTR	Glutamate	7MTR-mGlu2; mGlu2-Glutamate-ADX55164
14.29	Single	7MTR	Glutamate	7MTR-mGlu2; mGlu2-Glutamate-ADX55164
14.29	Single	7MTS	Glutamate	7MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/β1/γ2
14.29	Single	7MTS	Glutamate	7MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/β1/γ2
14.29	Single	7NA7	Ghrelin-27	7NA7-Ghrelin-Ghrelin-27-Gi1/β1/γ2
14.29	Single	7SIL	Ca	7SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
14.29	Single	7SIL	Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4	7SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
14.29	Single	7SIL	Ca	7SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
14.29	Single	7SIL	Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4	7SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
14.29	Single	7SIM	Ca	7SIM-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
14.29	Single	7SIM	Ca; Ca; Cyclomethyltryptophan; PO4	7SIM-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
14.29	Single	7SIM	Ca	7SIM-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
14.29	Single	7SIM	Ca; Ca; Cyclomethyltryptophan; PO4	7SIM-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
14.29	Single	7T9N	M22 Fab	7T9N-TSH-M22 Fab-DPPC-Gs/β1/γ2
14.29	Single	7TUZ	7-alpha,25-dihydroxycholesterol	7TUZ-GPR183-7-α,25-dihydroxycholesterol-Gi1/β1/γ2
14.29	Single	7VDL	Cortistatin-14	7VDL-MRGPRX2-Cortistatin-14-Gi1/β1/γ2
14.29	Single	7W0P	Elabela	7W0P-Apelin-Elabela-Gi1/β1/γ2
14.29	Single	7WF7	S1P	7WF7-S1P₁-S1P-Gi1/β1/γ2
14.29	Single	7WI6	LY341495	7WI6-mGlu3; mGlu3-LY341495
14.29	Single	7WI6	LY341495	7WI6-mGlu3; mGlu3-LY341495
14.29	Single	7WI8	LY341495	7WI8-mGlu3; mGlu3-LY341495
14.29	Single	7WI8	LY341495	7WI8-mGlu3; mGlu3-LY341495
14.29	Single	7WIH	LY2794193	7WIH-mGlu3; mGlu3-LY2794193
14.29	Single	7WIH	LY2794193	7WIH-mGlu3; mGlu3-LY2794193
14.29	Single	7X2C	Fenoldopam	7X2C-D₁-Fenoldopam-Fenoldopam-Gs/β1/γ2
14.29	Single	7XW6	M22 Fab	7XW6-TSH-M22 Fab-ML109-Gs/β1/γ2
14.29	Single	7XW7	K1-70	7XW7-TSH-K1-70
14.29	Single	8DU3	PubChem 105526064	8DU3-A_2A-PubChem 105526064
14.29	Single	8DWG	Proenkephalin-A	8DWG-MRGPRX1-Proenkephalin-A-ML382-chim(NtGi2L-Gs-CtGq)/β1/γ2
14.29	Single	8DWH	PubChem 139030531	8DWH-MRGPRX1-PubChem 139030531-chim(NtGi2L-Gs-CtGq)/β1/γ2
14.29	Single	8HDP	Adenosine	8HDP-A_2B-Adenosine-Gs/β1/γ2
14.29	Single	8IJA	Niacin	8IJA-HCA₂-Niacin-Gi1/β1/γ2
14.29	Single	8IJB	Acipimox	8IJB-HCA₂-Acipimox-Gi1/β1/γ2
14.29	Single	8J6L	Niacin	8J6L-HCA₂-Niacin-Gi1/β1/γ2
14.29	Single	8JCU	LY341495	8JCU-mGlu2; mGlu3-LY341495
14.29	Single	8JCU	LY341495	8JCU-mGlu2; mGlu3-LY341495
14.29	Single	8JCV	LY341495	8JCV-mGlu2; mGlu3-LY341495
14.29	Single	8JCV	LY341495	8JCV-mGlu2; mGlu3-LY341495
14.29	Single	8JCW	LY341495	8JCW-mGlu2; mGlu3-LY341495
14.29	Single	8JCW	LY341495	8JCW-mGlu2; mGlu3-LY341495
14.29	Single	8JCX	LY341495	8JCX-mGlu2; mGlu3-LY341495
14.29	Single	8JCX	LY341495	8JCX-mGlu2; mGlu3-LY341495
14.29	Single	8JCY	LY341495	8JCY-mGlu2; mGlu3-LY341495
14.29	Single	8JCY	LY341495	8JCY-mGlu2; mGlu3-LY341495
14.29	Single	8JCZ	LY341495	8JCZ-mGlu2; mGlu3-LY341495
14.29	Single	8JCZ	LY341495	8JCZ-mGlu2; mGlu3-LY341495
14.29	Single	8JD0	Glutamate	8JD0-mGlu2; mGlu3-Glutamate-NAM563
14.29	Single	8JD1	Glutamate	8JD1-mGlu2; mGlu3-Glutamate
14.29	Single	8JD1	Glutamate	8JD1-mGlu2; mGlu3-Glutamate
14.29	Single	8JD2	Glutamate	8JD2-mGlu2; mGlu3-Glutamate
14.29	Single	8JD2	Glutamate	8JD2-mGlu2; mGlu3-Glutamate
14.29	Single	8JD3	Glutamate	8JD3-mGlu2; mGlu3-Glutamate-JNJ-40411813-Gi1/β1/γ2
14.29	Single	8JD3	Glutamate	8JD3-mGlu2; mGlu3-Glutamate-JNJ-40411813-Gi1/β1/γ2
14.29	Single	8JD4	Glutamate	8JD4-mGlu2; mGlu4-Glutamate
14.29	Single	8JD4	Glutamate	8JD4-mGlu2; mGlu4-Glutamate
14.29	Single	8JD5	Glutamate	8JD5-mGlu2; mGlu4-Glutamate-JNJ-40411813; ADX88178-Gi1/β1/γ2
14.29	Single	8JD5	Glutamate	8JD5-mGlu2; mGlu4-Glutamate-JNJ-40411813; ADX88178-Gi1/β1/γ2
14.29	Single	8JD6	Phosphoserine	8JD6-mGlu4; mGlu4-Phosphoserine-VU0364770-Gi3/β1/γ2
14.29	Single	8JD6	Phosphoserine	8JD6-mGlu4; mGlu4-Phosphoserine-VU0364770-Gi3/β1/γ2
14.29	Single	8RVW	StilSwitch3	8RVW-A_2A-StilSwitch3-Na
14.29	Single	8RW0	Istradefylline	8RW0-A_2A-Istradefylline-Na
14.29	Single	8RW4	AzoSwitch2	8RW4-A_2A-AzoSwitch2-Na
14.29	Single	8RWE	StilSwitch4	8RWE-A_2A-StilSwitch4-Na
14.29	Single	8SZF	Ca; Ca; Tryptophan; Cinacalcet; PO4; Spermine	8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; Spermine
14.29	Single	8SZF	Ca; Ca; Tryptophan; Cinacalcet; PO4; Spermine	8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; Spermine
14.29	Single	8SZG	Ca; Ca; Tryptophan; Cinacalcet; PO4; Spermine	8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; Spermine-chim(NtGi1-Gq)/β1/γ2
14.29	Single	8T7H	Quisqualate	8T7H-mGlu5; mGlu5-Quisqualate
14.29	Single	8T7H	Quisqualate	8T7H-mGlu5; mGlu5-Quisqualate
14.29	Single	8T8M	Quisqualate	8T8M-mGlu5; mGlu5-Quisqualate
14.29	Single	8T8M	Quisqualate	8T8M-mGlu5; mGlu5-Quisqualate
14.29	Single	8TAO	Quisqualate	8TAO-mGlu5; mGlu5-Quisqualate-CDPPB
14.29	Single	8TAO	Quisqualate	8TAO-mGlu5; mGlu5-Quisqualate-CDPPB
14.29	Single	8TQB	Ca; PAM VU6023326	8TQB-mGlu3; mGlu3-Ca; PAM VU6023326-Ca
14.29	Single	8TQB	Ca; PAM VU6023326	8TQB-mGlu3; mGlu3-Ca; PAM VU6023326-Ca
14.29	Single	8TR0	LY341495	8TR0-mGlu3; mGlu3-LY341495
14.29	Single	8TR0	LY341495	8TR0-mGlu3; mGlu3-LY341495
14.29	Single	8TR2	Ca; LY379268	8TR2-mGlu3; mGlu3-Ca; LY379268-Ca
14.29	Single	8TR2	Ca; LY379268	8TR2-mGlu3; mGlu3-Ca; LY379268-Ca
14.29	Single	8TRC	LY341495	8TRC-mGlu3; mGlu3-LY341495
14.29	Single	8TRC	LY341495	8TRC-mGlu3; mGlu3-LY341495
14.29	Single	8TRD	LY341495	8TRD-mGlu3; mGlu3-LY341495
14.29	Single	8TRD	LY341495	8TRD-mGlu3; mGlu3-LY341495
14.29	Single	8U1U	CCL1	8U1U-CCR8-CCL1-Gi1/β1/γ2
14.29	Single	8U4S	REGN7663-Fab	8U4S-CXCR4-REGN7663-Fab
14.29	Single	8U4T	REGN7663-Fab	8U4T-CXCR4-REGN7663-Fab
14.29	Single	8WG9	(2S)-2-amino-4-phosphonobutanoic acid	8WG9-mGlu4; mGlu2-(2S)-2-amino-4-phosphonobutanoic acid
14.29	Single	8WGB	Glutammate	8WGB-mGlu4; mGlu2-Glutammate-VU0155041-Gi3/β1/γ2
14.29	Single	8WGB	Glutammate	8WGB-mGlu4; mGlu2-Glutammate-VU0155041-Gi3/β1/γ2
14.29	Single	8WGC	LY379268	8WGC-mGlu4; mGlu2-LY379268
14.29	Single	8WGD	WAG; WA6	8WGD-mGlu4; mGlu2-WAG; WA6
14.29	Single	8WGD	WAG; WA6	8WGD-mGlu4; mGlu2-WAG; WA6
14.29	Single	8WPG	Tryptophan; Cinacalcet; PO4; Ca	8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
14.29	Single	8WPG	Tryptophan; Cinacalcet; PO4; Ca	8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
14.29	Single	8WPU	Tryptophan; Cinacalcet; PO4; Ca	8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/β1/γ2
14.29	Single	8WPU	Tryptophan; Cinacalcet; PO4; Ca	8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/β1/γ2
14.29	Single	8WVX	Norrin	8WVX-LGR4-Norrin
14.29	Single	8WVY	Norrin	8WVY-LGR4-Norrin
14.29	Single	8X0B	Quisqualate	8X0B-mGlu5; mGlu5-Quisqualate-VU0424465
14.29	Single	8X0B	Quisqualate	8X0B-mGlu5; mGlu5-Quisqualate-VU0424465
14.29	Single	8X0C	Quisqualate	8X0C-mGlu5; mGlu5-Quisqualate-VU0424465
14.29	Single	8X0C	Quisqualate	8X0C-mGlu5; mGlu5-Quisqualate-VU0424465
14.29	Single	8X0D	Quisqualate	8X0D-mGlu5; mGlu5-Quisqualate-VU0424465
14.29	Single	8X0D	Quisqualate	8X0D-mGlu5; mGlu5-Quisqualate-VU0424465
14.29	Single	8X0E	Quisqualate	8X0E-mGlu5; mGlu5-Quisqualate
14.29	Single	8X0E	Quisqualate	8X0E-mGlu5; mGlu5-Quisqualate
14.29	Single	8X0F	Quisqualate	8X0F-mGlu5; mGlu5-Quisqualate-VU0424465
14.29	Single	8X0F	Quisqualate	8X0F-mGlu5; mGlu5-Quisqualate-VU0424465
14.29	Single	8X0G	Quisqualate	8X0G-mGlu5; mGlu5-Quisqualate
14.29	Single	8X0G	Quisqualate	8X0G-mGlu5; mGlu5-Quisqualate
14.29	Single	8X0H	Quisqualate	8X0H-mGlu5; mGlu5-Quisqualate
14.29	Single	8X0H	Quisqualate	8X0H-mGlu5; mGlu5-Quisqualate
14.29	Single	8XUM	R-spondin-2	8XUM-LGR4-R-spondin-2
14.29	Single	8YYW	Alpha-ketoglutarate	8YYW-Oxoglutarate-α-ketoglutarate-α-ketoglutarate-chim(Gi1-CtGq)/β1/γ2
14.29	Single	9ASB	Ca	9ASB-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
14.29	Single	9ASB	Ca; Ca; Cyclomethyltryptophan; 9IG; PO4	9ASB-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
14.29	Single	9AVG	Ca	9AVG-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs)/β1/γ2
14.29	Single	9AVG	Ca; Ca; Cyclomethyltryptophan; 9IG; PO4	9AVG-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs)/β1/γ2
14.29	Single	9AVL	Ca	9AVL-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi3/β2/γ2
14.29	Single	9AVL	Ca; Ca; Cyclomethyltryptophan; 9IG; PO4	9AVL-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi3/β2/γ2
14.29	Single	9AVL	Ca	9AVL-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi3/β2/γ2
14.29	Single	9AVL	Ca; Ca; Cyclomethyltryptophan; 9IG; PO4	9AVL-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi3/β2/γ2
14.29	Single	9AXF	Ca	9AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
14.29	Single	9AXF	Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4	9AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
14.29	Single	9AXF	Ca	9AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
14.29	Single	9AXF	Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4	9AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
14.29	Single	9AYF	Ca	9AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/β1/γ2
14.29	Single	9AYF	Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4	9AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/β1/γ2
14.29	Single	9C1P	Ca	9C1P-CaS-Ca-Ca; Tryptophan; '6218; PO4
14.29	Single	9C1P	Ca; Tryptophan; '6218; PO4	9C1P-CaS-Ca-Ca; Tryptophan; '6218; PO4
14.29	Single	9C1P	Ca	9C1P-CaS-Ca-Ca; Tryptophan; '6218; PO4
14.29	Single	9C1P	Ca; Tryptophan; '6218; PO4	9C1P-CaS-Ca-Ca; Tryptophan; '6218; PO4
14.29	Single	9C2F	Ca	9C2F-CaS-Ca-Ca; Ca; Tryptophan; '54149; PO4
14.29	Single	9C2F	Ca; Ca; Tryptophan; '54149; PO4	9C2F-CaS-Ca-Ca; Ca; Tryptophan; '54149; PO4
14.29	Single	9C2F	Ca	9C2F-CaS-Ca-Ca; Ca; Tryptophan; '54149; PO4
14.29	Single	9C2F	Ca; Ca; Tryptophan; '54149; PO4	9C2F-CaS-Ca-Ca; Ca; Tryptophan; '54149; PO4
14.29	Single	9FUP	Istradefylline	9FUP-A_2A-Istradefylline-Na
14.29	Single	9H2X	A1IR1	9H2X-A_2A-A1IR1-Na
14.29	Single	9II2	Glutamate	9II2-mGlu3; mGlu3-Glutamate-Arrestin2
14.29	Single	9II2	Glutamate	9II2-mGlu3; mGlu3-Glutamate-Arrestin2
14.29	Single	9II3	Glutamate	9II3-mGlu3; mGlu3-Glutamate-Arrestin2
14.29	Single	9II3	Glutamate	9II3-mGlu3; mGlu3-Glutamate-Arrestin2
14.29	Single	9J0I	UDP-Glucuronic acid	9J0I-P2Y₁₄-UDP-Glucuronic acid-Gi1/β1/γ2
14.29	Single	9KHH	Norrin	9KHH-LGR4-Norrin
14.29	Single	9S37	NB21	9S37-LGR4-NB21
14.29	Single	9UTB	Sucralose	9UTB-TAS1R2; TAS1R3-Sucralose
14.29	Consensus	ccr5_on_gp	Orthosteric Ligand	7O7F-CCR5-6P4-CCL5-Gi1/β1/γ1 7F1Q-CCR5-MIP-1a-Gi1/β1/γ2
14.29	Consensus	ccr6_on	Orthosteric Ligand	6WWZ-CCR6-CCL20-Go/β1/γ2
14.29	Consensus	ccr6_on_gp	Orthosteric Ligand	6WWZ-CCR6-CCL20-Go/β1/γ2
14.29	Consensus	gi_nucleotide	Orthosteric Ligand	gi_adenosine gi_p2y
14.29	Consensus	lpl_on	Orthosteric Ligand	s1p_on lpa_on
14.29	Consensus	lpl_on_gp	Orthosteric Ligand	s1p_on_gp lpa_on_gp
14.29	Consensus	mc4_on	Orthosteric Ligand	7AUE-MC₄-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2 7F58-MC₄-THIQ-Gs/β1/γ2 7F54-MC₄-Afamelanotide-Gs/β1/γ2 7F53-MC₄-α-MSH-Gs/β1/γ2 7F55-MC₄-Bremelanotide-Gs/β1/γ2
14.29	Consensus	nk3_on	Orthosteric Ligand	8JBF-NK₃-Senktide-chim(NtGi1-Gs-CtGq)/β1/γ2
14.29	Consensus	nk3_on_gp	Orthosteric Ligand	8JBF-NK₃-Senktide-chim(NtGi1-Gs-CtGq)/β1/γ2
14.29	Consensus	p2y_on	Orthosteric Ligand	p2y1_on p2y10_on p2y12_on
14.29	Consensus	paf_off	Orthosteric Ligand	5ZKQ-PAF-ABT-491
14.29	Consensus	s1p1_off	Orthosteric Ligand	3V2W-S1P₁-PubChem 51892645
13.79	Consensus	endothelin_on_gp	Orthosteric Ligand	etb_on_gp eta_on_gp
13.79	Consensus	melanocortin_on	Orthosteric Ligand	mc1_on mc4_on mc2_on mc3_on mc5_on
13.79	Consensus	melanocortin_on_gp	Orthosteric Ligand	mc1_on_gp mc4_on_gp mc2_on_gp mc3_on_gp mc5_on_gp
13.64	Single	3QAK	UK-432097	3QAK-A_2A-UK-432097
13.64	Single	5XJM	(Sar1,Ile8)-Angiotensin II	5XJM-AT₂-(Sar1,Ile8)-Angiotensin II
13.64	Single	6DO1	Angiotensin-like peptide S1I8	6DO1-AT₁-Angiotensin-like peptide S1I8
13.64	Single	7F1Q	MIP-1a	7F1Q-CCR5-MIP-1a-Gi1/β1/γ2
13.64	Single	7PIV	Setmelanotide	7PIV-MC₄-Setmelanotide-Gs/β1/γ2
13.64	Single	7RKM	Fractalkine	7RKM-US28-Fractalkine-Gi1/β1/γ2
13.64	Single	7RMI	Substance-P	7RMI-NK₁-Substance-P-chim(Gs-CtGq)/β1/γ2
13.64	Single	7SK5	CXCL12	7SK5-ACKR3-CXCL12
13.64	Single	8F7Q	Beta-Endorphin	8F7Q-μ-β-Endorphin-Gi1/β1/γ2
13.64	Single	8F7S	Deltorphin	8F7S-δ-Deltorphin-Gi1/β1/γ2
13.64	Single	8F7W	Dynorphin	8F7W-κ-Dynorphin-Gi1/β1/γ2
13.64	Single	9KFI	Relaxin-3	9KFI-RXFP3-Relaxin-3-Gi2/β1/γ2
13.64	Consensus	compl-peptide_on	Orthosteric Ligand	c5a1_on c3a_on
13.64	Consensus	dop_on_gp	Orthosteric Ligand	8F7S-δ-Deltorphin-Gi1/β1/γ2
13.64	Consensus	gi_ghrelin	Orthosteric Ligand	7NA7-Ghrelin-Ghrelin-27-Gi1/β1/γ2 7NA8-Ghrelin-PubChem 178024-Gi1/β1/γ2
13.64	Consensus	mc4_on_gp	Orthosteric Ligand	7AUE-MC₄-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2 7F58-MC₄-THIQ-Gs/β1/γ2 7F54-MC₄-Afamelanotide-Gs/β1/γ2 7F53-MC₄-α-MSH-Gs/β1/γ2 7F55-MC₄-Bremelanotide-Gs/β1/γ2
13.33	Single	3REY	XAC	3REY-A_2A-XAC
13.33	Single	3V2Y	PubChem 51892645	3V2Y-S1P₁-PubChem 51892645
13.33	Single	5IU7	Q27456346	5IU7-A_2A-Q27456346-Na
13.33	Single	5JTB	ZM-241385	5JTB-A_2A-ZM-241385
13.33	Single	5NLX	ZM-241385	5NLX-A_2A-ZM-241385-Na
13.33	Single	5UVI	ZM-241385	5UVI-A_2A-ZM-241385
13.33	Single	6FK8	PubChem 132473035	6FK8-Rhodopsin-PubChem 132473035
13.33	Single	6LRY	Sarafotoxin-B	6LRY-ET_B-Sarafotoxin-B
13.33	Single	6MH8	ZM-241385	6MH8-A_2A-ZM-241385
13.33	Single	6PEL	Citronellol	6PEL-Rhodopsin-Citronellol-Gt(CT)
13.33	Single	6U1N	LY2119620	6U1N-M₂-LY2119620-Arrestin2
13.33	Single	6WJC	Muscarinic toxin 7	6WJC-M₁-Atropine-Muscarinic toxin 7
13.33	Single	6ZDR	HMS1413f12	6ZDR-A_2A-HMS1413f12-Na
13.33	Single	7C2E	PubChem 149050799	7C2E-GLP-1-PubChem 149050799-Gs/β1/γ2
13.33	Single	7F61	PF-03654746	7F61-H₃-PF-03654746
13.33	Single	7T32	ZM-241385	7T32-A_2A-ZM-241385
13.33	Single	7T94	LY2119620	7T94-M₂-Acetylcholine-LY2119620-chim(NtGi1-Go)/β1/γ2
13.33	Single	7UTZ	DPPC	7UTZ-TSH-TR1402-DPPC-Gs/β1/γ2
13.33	Single	8GUQ	Olorinab	8GUQ-CB₂-Olorinab-Gi1/β1/γ2
13.33	Single	8H4L	Doconexent	8H4L-FFA4-Doconexent-chim(NtGi1-Gs-CtGq)/β1/γ2
13.33	Single	8HQN	9-S-HODE	8HQN-GPR132-9-S-HODE-Gi1/β1/γ2
13.33	Single	8IY9	Niacin	8IY9-HCA₂-Niacin-Go/β1/γ2
13.33	Single	8JER	Acipimox	8JER-HCA₂-Acipimox-Go/β1/γ2
13.33	Single	8K4N	VF0	8K4N-GPR34-VF0-Gi1/β1/γ2
13.33	Single	8K5C	Acipimox	8K5C-HCA₂-Acipimox
13.33	Single	8RQQ	ZM-241385	8RQQ-A_2A-ZM-241385-Na
13.33	Single	8RWC	StilSwitch2	8RWC-A_2A-StilSwitch2-Na
13.33	Single	8RWD	StilSwitch3	8RWD-A_2A-StilSwitch3-Na
13.33	Single	8RWI	StilSwitch2	8RWI-A_2A-StilSwitch2-Na
13.33	Single	8ZPN	AMD3100	8ZPN-CXCR4-AMD3100
13.33	Single	9JFU	NE52-QQ57	9JFU-GPR4-NE52-QQ57
13.33	Single	9M2F	Neuropeptide FF	9M2F-NPFF1-Neuropeptide FF-Gi1/β1/γ2
13.33	Consensus	a2_off	Orthosteric Ligand	a2a_off
13.33	Consensus	a2a_off	Orthosteric Ligand	3RFM-A_2A-Caffeine 8C9W-A_2A-Etrumadenant 3UZA-A_2A-GTPL9236 8GNG-A_2A-Istradefylline 8CU6-A_2A-LJ-4517 7PX4-A_2A-PSB-2113 7PYR-A_2A-PSB-2115 8DU3-A_2A-PubChem 105526064 8JWY-A_2A-2-118 8PWN-A_2A-Theophylline 5IU4-A_2A-ZM-241385-Na 5OLZ-A_2A-PubChem 135566609-Na 6GT3-A_2A-Imaradenant-Na 5OLV-A_2A-LUAA41063-Na 5N2R-A_2A-PSB-36-Na 5IU7-A_2A-Q27456346-Na 5OLH-A_2A-Vipadenant-Na 5OLO-A_2A-Tozadenant-Na 6ZDR-A_2A-HMS1413f12-Na 8GNE-A_2A-KW-6356-Na 8JWZ-A_2A-AB928-Na 5IU8-A_2A-Q27456347-Na 5IUB-A_2A-Q27456344-Na 6ZDV-A_2A-Chromone 5d-Na 5IUA-A_2A-Q27456348-Na 8A2P-A_2A-LUAA47070-Na
13.33	Consensus	adenosine_on	Orthosteric Ligand	a1_on a2_on a3_on
13.33	Consensus	cb1_off	Orthosteric Ligand	5U09-CB₁-Taranabant 5TGZ-CB₁-AM6538
13.33	Consensus	cxcr2_on	Orthosteric Ligand	6LFM-CXCR2-Interleukin-8-Gi1/β1/γ2
13.33	Consensus	gi_adenosine	Orthosteric Ligand	7LD4-A₁-Adenosine-Gi2/β1/γ2 8X17-A_3A-Namodenoson-Gi1/β1/γ2 8X16-A_3A-Piclidenoson-Gi1/β1/γ2
13.04	Single	6LW5	WKYMVm	6LW5-FPR2-ALX-WKYMVm
13.04	Single	6MEO	Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4	6MEO-CCR5-Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4
13.04	Single	7RYC	Oxytocin	7RYC-OT-Oxytocin-chim(NtGi2L-Gs-CtGq)/β1/γ2
13.04	Single	7TD0	LPA	7TD0-LPA₁-LPA-Gi1/β1/γ2
13.04	Single	7XA3	CCL2	7XA3-CCR2-CCL2-Gi1/β1/γ2
13.04	Single	8K6N	Pro-neuropeptide-Y	8K6N-Y₂-Pro-neuropeptide-Y-Gi2/β1/γ1
13.04	Single	8WKZ	SBL-MC-31	8WKZ-MC₄-SBL-MC-31
13.04	Single	9M1O	Morphine-Modulating Neuropeptide B	9M1O-NPFF2-Morphine-Modulating Neuropeptide B-Gi1/β1/γ2
13.04	Single	9U4W	Gonadoliberin-1	9U4W-GnRH₁-Gonadoliberin-1-chim(NtGi1L-Gs-CtGq)/β1/γ2
13.04	Consensus	angiotensin_on	Orthosteric Ligand	at1_on
13.04	Consensus	at1_on	Orthosteric Ligand	7F6G-AT₁-SAR1-AngII-Gq/β1/γ2
13.04	Consensus	c5a1_on	Orthosteric Ligand	8HK5-C5a₁-Complement C5-Gi1/β1/γ2 7Y66-C5a₁-BM213-Gi1/β1/γ2 7Y67-C5a₁-C089 peptide-Gi1/β1/γ2 7Y64-C5a₁-C5a anaphylatoxin-Gi1/β1/γ2
13.04	Consensus	ccr2_on	Orthosteric Ligand	7XA3-CCR2-CCL2-Gi1/β1/γ2
13.04	Consensus	ccr2_on_gp	Orthosteric Ligand	7XA3-CCR2-CCL2-Gi1/β1/γ2
13.04	Consensus	ccr_on	Orthosteric Ligand	ccr6_on ccr8_on ccr2_on ccr1_on ccr5_on
13.04	Consensus	compl-peptide_on_gp	Orthosteric Ligand	c5a1_on_gp c3a_on_gp
12.50	Single	3EML	ZM-241385	3EML-A_2A-ZM-241385
12.50	Single	5K2A	ZM-241385	5K2A-A_2A-ZM-241385-Na
12.50	Single	5OLZ	PubChem 135566609	5OLZ-A_2A-PubChem 135566609-Na
12.50	Single	5OM1	PubChem 135566609	5OM1-A_2A-PubChem 135566609-Na
12.50	Single	5T04	Neurotensin	5T04-NTS₁-Neurotensin
12.50	Single	5TGZ	AM6538	5TGZ-CB₁-AM6538
12.50	Single	5UIG	Cmpd-1	5UIG-A_2A-Cmpd-1
12.50	Single	5VRA	ZM-241385	5VRA-A_2A-ZM-241385-Na
12.50	Single	6D27	CAY10471	6D27-DP₂-CAY10471
12.50	Single	6FK7	PubChem 132473034	6FK7-Rhodopsin-PubChem 132473034
12.50	Single	6FKC	PubChem 132473039	6FKC-Rhodopsin-PubChem 132473039
12.50	Single	6JOD	Angiotensin II	6JOD-AT₂-Angiotensin II
12.50	Single	6KPF	PubChem 145915889	6KPF-CB₂-PubChem 145915889-Gi1/β1/γ2
12.50	Single	6MET	Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4	6MET-CCR5-Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4
12.50	Single	6S0L	ZM-241385	6S0L-A_2A-ZM-241385
12.50	Single	6X1A	Danuglipron	6X1A-GLP-1-Danuglipron-Gs/β1/γ2
12.50	Single	6Z4V	NTS8-13	6Z4V-NTS₁-NTS8-13
12.50	Single	7DD6	Ca	7DD6-CaS-Ca-Ca; Ca; Tryptophan
12.50	Single	7DD6	Ca; Ca; Tryptophan	7DD6-CaS-Ca-Ca; Ca; Tryptophan
12.50	Single	7DD6	Ca	7DD6-CaS-Ca-Ca; Ca; Tryptophan
12.50	Single	7DD6	Ca; Ca; Tryptophan	7DD6-CaS-Ca-Ca; Ca; Tryptophan
12.50	Single	7DD7	Ca	7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
12.50	Single	7DD7	Ca; Ca; Tryptophan; Evocalcet	7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
12.50	Single	7DD7	Ca	7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
12.50	Single	7DD7	Ca; Ca; Tryptophan; Evocalcet	7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
12.50	Single	7DW9	AVP	7DW9-V₂-AVP-chim(NtGi1-Gs)/β1/γ2
12.50	Single	7F6G	SAR1-AngII	7F6G-AT₁-SAR1-AngII-Gq/β1/γ2
12.50	Single	7KH0	AVP	7KH0-V₂-AVP-chim(NtGi1-Gs)/β1/γ2
12.50	Single	7LCK	Danuglipron	7LCK-GLP-1-Danuglipron
12.50	Single	7S15	PubChem 134611223	7S15-GLP-1-PubChem 134611223
12.50	Single	7TRQ	VU0467154	7TRQ-M₄-Iperoxo-VU0467154-Gi1/β1/γ2
12.50	Single	7YK7	DC591053	7YK7-RXFP4-DC591053-Gi2/β1/γ2
12.50	Single	7YON	Peptide-YY(3-36)	7YON-Y₂-Peptide-YY(3-36)-Gi1/β1/γ2
12.50	Single	7YXA	ONO-5430608	7YXA-S1P₅-ONO-5430608
12.50	Single	8CU6	LJ-4517	8CU6-A_2A-LJ-4517
12.50	Single	8CU7	LJ-4517	8CU7-A_2A-LJ-4517-Na
12.50	Single	8EJK	TAK-875	8EJK-FFA1-TAK-875-chim(NtGi1L-Gs-CtGq)/β1/γ2
12.50	Single	8H4K	GW9508	8H4K-FFA4-GW9508-chim(NtGi1-Gs-CtGq)/β1/γ2
12.50	Single	8I7V	Acipimox	8I7V-HCA₂-Acipimox-Gi1/β1/γ2
12.50	Single	8IHF	MK6892	8IHF-HCA₂-MK6892-Gi1/β1/γ2
12.50	Single	8IHJ	Acifran	8IHJ-HCA₃-Acifran-Gi1/β1/γ2
12.50	Single	8J6I	MK6892	8J6I-HCA₂-MK6892-Gi1/β1/γ2
12.50	Single	8JHN	MMF	8JHN-HCA₂-MMF-Go/β1/γ2
12.50	Single	8JII	Niacin	8JII-HCA₂-Niacin-Compound 9n-Gi1/β1/γ2
12.50	Single	8RWX	StilSwitch3	8RWX-A_2A-StilSwitch3-Na
12.50	Single	8SZF	Ca; Ca; Tryptophan; Cinacalcet; PO4; Spermine	8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; Spermine
12.50	Single	8SZF	Ca; Ca; Tryptophan; Cinacalcet; PO4; Spermine	8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; Spermine
12.50	Single	8X17	Namodenoson	8X17-A_3A-Namodenoson-Gi1/β1/γ2
12.50	Single	8X8L	Cortistatin	8X8L-SST5-Cortistatin-chim(NtGi1-Gs-CtGi1)/β1/γ2
12.50	Single	8XJL	PGF2-alpha	8XJL-FP-alpha-PGF2-α-chim(NtGi2-Gs-CtGq)/β1/γ2
12.50	Single	8XZJ	WN353	8XZJ-Apelin-WN353-Gi1/β1/γ2
12.50	Single	8ZBE	Octreotide	8ZBE-SST5-Octreotide-Gi1/β1/γ1
12.50	Single	9ASB	Ca	9ASB-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
12.50	Single	9ASB	Ca; Ca; Cyclomethyltryptophan; 9IG; PO4	9ASB-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
12.50	Single	9AVG	Ca	9AVG-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs)/β1/γ2
12.50	Single	9AVG	Ca; Ca; Cyclomethyltryptophan; 9IG; PO4	9AVG-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs)/β1/γ2
12.50	Single	9AYF	Ca	9AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/β1/γ2
12.50	Single	9AYF	Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4	9AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/β1/γ2
12.50	Single	9H37	A1IR0	9H37-A_2A-A1IR0-Na
12.50	Single	9IMA	Talquetamab	9IMA-GPRC5D-Talquetamab
12.50	Single	9IZC	MK1903	9IZC-HCA₂-MK1903-Gi1/β1/γ2
12.50	Consensus	a3_on	Orthosteric Ligand	a3a_on
12.50	Consensus	adenosine_on_gp	Orthosteric Ligand	a1_on_gp a2_on_gp a3_on_gp
12.50	Consensus	angiotensin_on_gp	Orthosteric Ligand	at1_on_gp
12.50	Consensus	at1_on_gp	Orthosteric Ligand	7F6G-AT₁-SAR1-AngII-Gq/β1/γ2
12.50	Consensus	c5a1_on_gp	Orthosteric Ligand	8HK5-C5a₁-Complement C5-Gi1/β1/γ2 7Y66-C5a₁-BM213-Gi1/β1/γ2 7Y67-C5a₁-C089 peptide-Gi1/β1/γ2 7Y64-C5a₁-C5a anaphylatoxin-Gi1/β1/γ2
12.50	Consensus	class-b2_on	Orthosteric Ligand	adgrg_on adgrf_on adgrl_on adgre_on adgrd_on
12.50	Consensus	class-b2_on_gp	Orthosteric Ligand	adgrg_on_gp adgrf_on_gp adgrl_on_gp adgre_on_gp adgrd_on_gp
12.50	Consensus	crf2_on	Orthosteric Ligand	7TS0-CRF₂-Urocortin-chim(NtGi1L-Go)/β1/γ2
12.50	Consensus	cxcr3_on_gp	Orthosteric Ligand	8HNK-CXCR3-CXCL11-Gi1/β1/γ2 8HNL-CXCR3-PS372424-Gi1/β1/γ2
12.50	Consensus	gi_class-a	Orthosteric Ligand	gi_peptide gi_sensory gi_alicarboxylic gi_amine gi_lipid gi_nucleotide gi_protein
12.50	Consensus	gq_angiotensin	Orthosteric Ligand	7F6G-AT₁-SAR1-AngII-Gq/β1/γ2
12.50	Consensus	gs_vasop-oxy	Orthosteric Ligand	7DW9-V₂-AVP-chim(NtGi1-Gs)/β1/γ2
12.50	Consensus	lipid_off	Orthosteric Ligand	cannabinoid_off paf_off lpl_off prostanoid_off leukotriene_off
12.50	Consensus	p2y_on_gp	Orthosteric Ligand	p2y1_on_gp p2y10_on_gp p2y12_on_gp
12.50	Consensus	protein_on	Orthosteric Ligand	chemokine_on chemerin_on
12.50	Consensus	v2_on	Orthosteric Ligand	7DW9-V₂-AVP-chim(NtGi1-Gs)/β1/γ2
12.50	Consensus	v2_on_gp	Orthosteric Ligand	7DW9-V₂-AVP-chim(NtGi1-Gs)/β1/γ2
12.50	Consensus	vasop-oxy_on	Orthosteric Ligand	v2_on
12.50	Consensus	vasop-oxy_on_gp	Orthosteric Ligand	v2_on_gp
12.00	Single	7F9Y	Ghrelin-28	7F9Y-Ghrelin-Ghrelin-28-chim(NtGi1-Gs-CtGq)/β1/γ2
12.00	Single	7P02	Protachykinin-1	7P02-NK₁-Protachykinin-1-chim(NtGi1-Gs)/β1/γ2
12.00	Single	7VL9	CCL15(26-92)	7VL9-CCR1-CCL15(26-92)-Gi1/β1/γ2
12.00	Single	7Y64	C5a anaphylatoxin	7Y64-C5a₁-C5a anaphylatoxin-Gi1/β1/γ2
12.00	Single	8HCX	Endothelin-1	8HCX-ET_B-Endothelin-1-chim(NtGi2L-Gs-CtGq)/β1/γ2
12.00	Single	8HK5	Complement C5	8HK5-C5a₁-Complement C5-Gi1/β1/γ2
12.00	Single	8ZPS	PrRP20	8ZPS-PrRP-PrRP20-chim(NtGi1-Gs-CtGq)/β1/γ2
12.00	Single	9JFY	hNPSF	9JFY-NPFF2-hNPSF-Gi1/β1/γ2
12.00	Consensus	ccr_on_gp	Orthosteric Ligand	ccr6_on_gp ccr8_on_gp ccr2_on_gp ccr1_on_gp ccr5_on_gp
12.00	Consensus	opioid_on	Orthosteric Ligand	mop_on nop_on dop_on kop_on
11.76	Single	4PHU	Fasiglifam	4PHU-FFA1-Fasiglifam
11.76	Single	5N2R	PSB-36	5N2R-A_2A-PSB-36-Na
11.76	Single	5N2S	PSB36	5N2S-A₁-PSB36
11.76	Single	5OM4	PubChem 135566609	5OM4-A_2A-PubChem 135566609-Na
11.76	Single	5YHL	PubChem 135121352	5YHL-EP₄-PubChem 135121352
11.76	Single	5YWY	ONO-AE3-208	5YWY-EP₄-ONO-AE3-208
11.76	Single	6D26	Fevipiprant	6D26-DP₂-Fevipiprant
11.76	Single	6GDG	NECA	6GDG-A_2A-NECA-Gs/β1/γ1
11.76	Single	6M9T	Misoprostol-FA	6M9T-EP₃-Misoprostol-FA
11.76	Single	7CFN	INT-777	7CFN-GPBA-INT-777-Gs/β1/γ2
11.76	Single	7EO2	FTY720-P	7EO2-S1P₁-FTY720-P-Gi1/β1/γ2
11.76	Single	7EPF	NAM597	7EPF-mGlu2; mGlu2-NAM597
11.76	Single	7LD3	Adenosine	7LD3-A₁-Adenosine-MIPS521-Gi2/β1/γ2
11.76	Single	7TD3	S1P	7TD3-S1P₁-S1P-Gi1/β1/γ2
11.76	Single	7VV0	PAMP-12	7VV0-MRGPRX2-PAMP-12
11.76	Single	7VV4	Cortistatin-14	7VV4-MRGPRX2-Cortistatin-14
11.76	Single	7Y26	Octreotide	7Y26-SST2-Octreotide-chim(NtGi2L-Gs-CtGq)/β1/γ2
11.76	Single	8EJC	TAK-875	8EJC-FFA1-TAK-875-chim(NtGi1L-Gs-CtGq)/β1/γ2
11.76	Single	8GD9	Rivenprost	8GD9-EP₄-Rivenprost-Gs/β1/γ2
11.76	Single	8GNE	KW-6356	8GNE-A_2A-KW-6356-Na
11.76	Single	8ID4	Linoleic acid	8ID4-FFA4-Linoleic acid-Gi1/β1/γ2
11.76	Single	8IZ4	Lysophosphatidylserine	8IZ4-GPR34-Lysophosphatidylserine-Gi1/β1/γ2
11.76	Single	8J6J	GSK256073	8J6J-HCA₂-GSK256073-Gi1/β1/γ2
11.76	Single	8QOT	Nanobody-E	8QOT-μ-Nanobody-E
11.76	Single	8TF5	Oleic acid	8TF5-GPR6-Oleic acid
11.76	Single	8UUJ	FCH-2296413	8UUJ-HCA₂-FCH-2296413-Gi1/β1/γ2
11.76	Single	8YIC	SAR247799	8YIC-S1P₁-SAR247799-Gi1/β1/γ2
11.76	Single	8ZPT	PrRP20	8ZPT-PrRP-PrRP20-chim(NtGi1-Gs-CtGq)/β1/γ2
11.76	Single	8ZYT	Neurotensin peptide 8-13	8ZYT-NTS₁-Neurotensin peptide 8-13-SBI-553-Arrestin2
11.76	Single	9CIB	FCH-2296413	9CIB-HCA₂-FCH-2296413
11.76	Single	9EE8	Adenosine	9EE8-A_2A-Adenosine-Gs/β1/γ2
11.76	Single	9EHS	LUF7602	9EHS-A_3A-LUF7602
11.76	Single	9ERX	D9-THC analog	9ERX-CB₁-D9-THC analog-Gi1/β1/γ2
11.76	Single	9GE2	ML184	9GE2-GPR55-ML184-chim(NtGi1-G13)/β1/γ2
11.76	Consensus	a3_on_gp	Orthosteric Ligand	a3a_on_gp
11.76	Consensus	a3a_on	Orthosteric Ligand	8X17-A_3A-Namodenoson-Gi1/β1/γ2 8X16-A_3A-Piclidenoson-Gi1/β1/γ2
11.76	Consensus	a3a_on_gp	Orthosteric Ligand	8X17-A_3A-Namodenoson-Gi1/β1/γ2 8X16-A_3A-Piclidenoson-Gi1/β1/γ2
11.76	Consensus	dp2_off	Orthosteric Ligand	6D26-DP₂-Fevipiprant
11.76	Consensus	dp_off	Orthosteric Ligand	dp2_off
11.76	Consensus	ep4_off	Orthosteric Ligand	5YWY-EP₄-ONO-AE3-208 5YHL-EP₄-PubChem 135121352
11.76	Consensus	ep_off	Orthosteric Ligand	ep4_off
11.76	Consensus	rxfp4_on	Orthosteric Ligand	7YK7-RXFP4-DC591053-Gi2/β1/γ2 7YJ4-RXFP4-INSL5-Gi2/β1/γ2 7YK6-RXFP4-PubChem 138319674-Gi2/β1/γ2
11.76	Consensus	rxfp4_on_gp	Orthosteric Ligand	7YK7-RXFP4-DC591053-Gi2/β1/γ2 7YJ4-RXFP4-INSL5-Gi2/β1/γ2 7YK6-RXFP4-PubChem 138319674-Gi2/β1/γ2
11.54	Single	4XT3	Fractalkine	4XT3-US28-Fractalkine
11.54	Single	8XVE	BQ3020	8XVE-ET_B-BQ3020-chim(Gs-CtGq)/β1/γ2
11.54	Consensus	crf2_on_gp	Orthosteric Ligand	7TS0-CRF₂-Urocortin-chim(NtGi1L-Go)/β1/γ2
11.54	Consensus	ctlike_on	Orthosteric Ligand	6E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/β1/γ2; RAMP1
11.54	Consensus	gi_compl-pept	Orthosteric Ligand	8HK5-C5a₁-Complement C5-Gi1/β1/γ2 8IA8-C3a_B-E7 peptide-Gi1/β1/γ2 7Y66-C5a₁-BM213-Gi1/β1/γ2 7Y67-C5a₁-C089 peptide-Gi1/β1/γ2 8HK2-C3a_B-C3a anaphylatoxin-Gi1/β1/γ2 7Y64-C5a₁-C5a anaphylatoxin-Gi1/β1/γ2
11.54	Consensus	gi_peptide	Orthosteric Ligand	gi_cck gi_apelin gi_compl-pept gi_endothelin gi_formylpeptide gi_galanin gi_ghrelin gi_npy gi_neurotensin gi_opioid gi_orexin gi_relaxin gi_somatostatin
11.54	Consensus	gi_protein	Orthosteric Ligand	gi_chemokine gi_chemerin
11.54	Consensus	opioid_on_gp	Orthosteric Ligand	mop_on_gp nop_on_gp dop_on_gp kop_on_gp
11.54	Consensus	pac1_on	Orthosteric Ligand	8E3X-PAC₁-PACAP27-Gs/β1/γ2 6M1H-PAC₁-Maxadilan-Gs/β1/γ2
11.54	Consensus	pac1_on_gp	Orthosteric Ligand	8E3X-PAC₁-PACAP27-Gs/β1/γ2 6M1H-PAC₁-Maxadilan-Gs/β1/γ2
11.54	Consensus	protein_on_gp	Orthosteric Ligand	chemokine_on_gp chemerin_on_gp
11.11	Single	3ZEV	Neurotensin	3ZEV-NTS₁-Neurotensin
11.11	Single	4BV0	Neurotensin	4BV0-NTS₁-Neurotensin
11.11	Single	4Z34	ONO-9780307	4Z34-LPA₁-ONO-9780307
11.11	Single	5TZR	MK8666	5TZR-FFA1-MK8666
11.11	Single	6GT3	Imaradenant	6GT3-A_2A-Imaradenant-Na
11.11	Single	6J21	Aprepitant	6J21-NK₁-Aprepitant
11.11	Single	6N4B	MDMB-Fubinaca	6N4B-CB₁-MDMB-Fubinaca-Gi1/β1/γ2
11.11	Single	6Z8N	SRI-9829	6Z8N-NTS₁-SRI-9829
11.11	Single	7F4F	Afamelanotide	7F4F-MC₁-Afamelanotide-chim(NtGi1-Gs)/β1/γ2
11.11	Single	7F53	Alpha-MSH	7F53-MC₄-α-MSH-Gs/β1/γ2
11.11	Single	7KNU	Calcitonin gene-related peptide-1	7KNU-CT Like-Calcitonin gene-related peptide-1-RAMP1
11.11	Single	7L0P	Neurotensin	7L0P-NTS₁-Neurotensin-Gi1/β1/γ1
11.11	Single	7L0Q	Neurotensin	7L0Q-NTS₁-Neurotensin-Gi1/β1/γ1
11.11	Single	7S8M	Cortistatin-14	7S8M-MRGPRX2-Cortistatin-14-Gi1/β1/γ2
11.11	Single	7T9M	CS-17 Antibody	7T9M-TSH-CS-17 Antibody
11.11	Single	7T9N	DPPC	7T9N-TSH-M22 Fab-DPPC-Gs/β1/γ2
11.11	Single	7VIG	CBP-307	7VIG-S1P₁-CBP-307-Gi1/β1/γ2
11.11	Single	7XAT	Somatostatin-14	7XAT-SST2-Somatostatin-14-Gi1/β1/γ2
11.11	Single	7Y24	Octreotide	7Y24-SST2-Octreotide-Go/β1/γ2
11.11	Single	7YOO	Neuropeptide-Y	7YOO-Y₂-Neuropeptide-Y-Gi1/β1/γ2
11.11	Single	8DCS	Cyanopindolol	8DCS-β₁-Cyanopindolol-Gs/β1/γ2
11.11	Single	8FN1	Neurotensin/Neuromedin-N	8FN1-NTS₁-Neurotensin/Neuromedin-N-chim(NtGi1-Go)/β1/γ2
11.11	Single	8I2G	Compound 716340	8I2G-FSH-Glycoprotein hormones α chain-Compound 716340-Gs/β1/γ2
11.11	Single	8I9L	C3a anaphylatoxin	8I9L-C3a_B-C3a anaphylatoxin-Go/β1/γ2
11.11	Single	8IHB	GSK256073	8IHB-HCA₂-GSK256073-Gi1/β1/γ2
11.11	Single	8IHH	LUF6283	8IHH-HCA₂-LUF6283-Gi1/β1/γ2
11.11	Single	8IYH	MK6892	8IYH-HCA₂-MK6892-Go/β1/γ2
11.11	Single	8JBG	Neurokinin-B	8JBG-NK₃-Neurokinin-B-chim(NtGi1-Gs-CtGq)/β1/γ2
11.11	Single	8JGF	BAM8-22	8JGF-MRGPRX1-BAM8-22-chim(NtGi1-Gs-CtGq)/β1/γ2
11.11	Single	8JZP	C5A anaphylatoxin	8JZP-C5a₁-C5A anaphylatoxin-Go/β1/γ2
11.11	Single	8T1V	PubChem 118310209	8T1V-GPR6-PubChem 118310209-Na
11.11	Single	8TLM	Anti-murine CCR8 antibody	8TLM-CCR8-Anti-murine CCR8 antibody
11.11	Single	8W8X	Beta-MSH	8W8X-MC₃-β-MSH-Ca-Gs/β1/γ2
11.11	Single	8WU1	PubChem 119025665	8WU1-CB₁-PubChem 119025665-Arrestin2
11.11	Single	8X16	Piclidenoson	8X16-A_3A-Piclidenoson-Gi1/β1/γ2
11.11	Single	8XBI	S3E-LysoPS	8XBI-GPR34-S3E-LysoPS
11.11	Single	8YH6	Namodenoson	8YH6-A_3A-Namodenoson-Gi1/β1/γ2
11.11	Single	8ZH8	QRF-Amide	8ZH8-QRFP-QRF-Amide-Gq/β1/γ1
11.11	Single	8ZW0	PGD2	8ZW0-DP₁-PGD2-Gs/β1/γ2
11.11	Single	9AST	Lymphotactin	9AST-XCR1-Lymphotactin-Gi1/β1/γ2
11.11	Single	9B65	KCA	9B65-CB₁-KCA-Gi1/β1/γ2
11.11	Single	9EGO	YVF	9EGO-CB₁-YVF-Gi1/β1/γ2
11.11	Consensus	a2_on	Orthosteric Ligand	a2b_on
11.11	Consensus	a2_on_gp	Orthosteric Ligand	a2b_on_gp
11.11	Consensus	a2b_on	Orthosteric Ligand	8HDP-A_2B-Adenosine-Gs/β1/γ2 7XY6-A_2B-BAY 60-6583-chim(NtGi1-Gs)/β1/γ2 7XY7-A_2B-NECA-chim(NtGi1-Gs)/β1/γ2 8HDO-A_2B-BAY 60-6583-Gs/β1/γ2
11.11	Consensus	a2b_on_gp	Orthosteric Ligand	8HDP-A_2B-Adenosine-Gs/β1/γ2 7XY6-A_2B-BAY 60-6583-chim(NtGi1-Gs)/β1/γ2 7XY7-A_2B-NECA-chim(NtGi1-Gs)/β1/γ2 8HDO-A_2B-BAY 60-6583-Gs/β1/γ2
11.11	Consensus	ffa2_on	Orthosteric Ligand	8J22-FFA2-TUG-1375-Gi1/β1/γ2
11.11	Consensus	ffa_on	Orthosteric Ligand	ffa2_on ffa3_on
11.11	Consensus	ffa_on_gp	Orthosteric Ligand	ffa2_on_gp ffa3_on_gp
11.11	Consensus	gi_ffa	Orthosteric Ligand	8J21-FFA3-Butyric acid-Gi1/β1/γ2 8J22-FFA2-TUG-1375-Gi1/β1/γ2
11.11	Consensus	gi_relaxin	Orthosteric Ligand	7YK7-RXFP4-DC591053-Gi2/β1/γ2 7YJ4-RXFP4-INSL5-Gi2/β1/γ2 7YK6-RXFP4-PubChem 138319674-Gi2/β1/γ2
11.11	Consensus	gs_adenosine	Orthosteric Ligand	8HDP-A_2B-Adenosine-Gs/β1/γ2 8HDO-A_2B-BAY 60-6583-Gs/β1/γ2 7XY7-A_2B-NECA-chim(NtGi1-Gs)/β1/γ2 7XY6-A_2B-BAY 60-6583-chim(NtGi1-Gs)/β1/γ2
11.11	Consensus	gs_nucleotide	Orthosteric Ligand	gs_adenosine
11.11	Consensus	motilin_on	Orthosteric Ligand	8IBU-Motilin-Erythromycin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
11.11	Consensus	neurotensin_on	Orthosteric Ligand	nts1_on
11.11	Consensus	npy2_on	Orthosteric Ligand	7YOO-Y₂-Neuropeptide-Y-Gi1/β1/γ2
11.11	Consensus	npy2_on_gp	Orthosteric Ligand	7YOO-Y₂-Neuropeptide-Y-Gi1/β1/γ2
11.11	Consensus	nts1_on	Orthosteric Ligand	6OSA-NTS₁-JMV449-Gi1/β1/γ2 7L0S-NTS₁-Neurotensin-Gi1/β1/γ1
11.11	Consensus	p2y12_on	Orthosteric Ligand	7XXI-P2Y₁₂-2MeSADP-Gi2/β1/γ2
11.11	Consensus	relaxin_on	Orthosteric Ligand	rxfp4_on
11.11	Consensus	relaxin_on_gp	Orthosteric Ligand	rxfp4_on_gp
10.71	Single	5VAI	GLP-1	5VAI-GLP-1-GLP-1-Gs/β1/γ2
10.71	Single	6IGL	IRL1620	6IGL-ET_B-IRL1620
10.71	Consensus	ctlike_on_gp	Orthosteric Ligand	6E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/β1/γ2; RAMP1
10.71	Consensus	etb_on	Orthosteric Ligand	8IY5-ET_B-Endothelin-1-Gi1/β1/γ2 8HBD-ET_B-IRL1620-Gi1/β1/γ2
10.71	Consensus	pth1_on	Orthosteric Ligand	6NBF-PTH1-Long-Acting PTH Analog-Gs/β1/γ2 8HA0-PTH1-PTH-chim(NtGi1-Gs)/β1/γ2 8HAF-PTH1-PTHrP(1-36)-chim(NtGi1-Gs)/β1/γ2 7Y36-PTH1-Teriparatide-Gs/β1/γ2 7Y35-PTH1-Abaloparatide-Gs/β1/γ2
10.53	Single	2YCX	Cyanopindolol	2YCX-β₁-Cyanopindolol
10.53	Single	4GRV	Neurotensin-(8-13)	4GRV-NTS₁-Neurotensin-(8-13)
10.53	Single	4N4W	SANT-1	4N4W-SMO-SANT-1
10.53	Single	4XEE	Neurotensin	4XEE-NTS₁-Neurotensin
10.53	Single	4XES	Neurotensin	4XES-NTS₁-Neurotensin
10.53	Single	4Z36	ONO-3080573	4Z36-LPA₁-ONO-3080573
10.53	Single	5TZY	MK8666; AP8	5TZY-FFA1-MK8666; AP8
10.53	Single	6AK3	Dinoprostone IPGE2	6AK3-EP₃-Dinoprostone IPGE2
10.53	Single	6KPG	AM841	6KPG-CB₁-AM841-Gi1/β1/γ2
10.53	Single	6OS0	Angiotensinogen	6OS0-AT₁-Angiotensinogen
10.53	Single	6OSA	JMV449	6OSA-NTS₁-JMV449-Gi1/β1/γ2
10.53	Single	6RZ7	ONO-2570366	6RZ7-CysLT₂-ONO-2570366
10.53	Single	6YVR	NTS8-13	6YVR-NTS₁-NTS8-13
10.53	Single	7DH5	Mirabegron	7DH5-β₃-Mirabegron-Gs/β1/γ2
10.53	Single	7EVY	Siponimod	7EVY-S1P₁-Siponimod-Gi1/β1/γ2
10.53	Single	7EW2	Fingolimod	7EW2-S1P₃-Fingolimod-Gi1/β1/γ2
10.53	Single	7EXD	Lasmiditan	7EXD-5-HT_1F-Lasmiditan-Gi1/β1/γ2
10.53	Single	7F55	Bremelanotide	7F55-MC₄-Bremelanotide-Gs/β1/γ2
10.53	Single	7MTR	ADX55164	7MTR-mGlu2; mGlu2-Glutamate-ADX55164
10.53	Single	7T6B	S1P	7T6B-S1P₂-S1P-chim(NtGi1L-G13)/β1/γ2
10.53	Single	7W0N	Elabela	7W0N-Apelin-Elabela-Gi1/β1/γ2
10.53	Single	7XW6	ML109	7XW6-TSH-M22 Fab-ML109-Gs/β1/γ2
10.53	Single	7XXI	2MeSADP	7XXI-P2Y₁₂-2MeSADP-Gi2/β1/γ2
10.53	Single	8GCP	PGE2	8GCP-EP₄-PGE2-Gi1/β1/γ2
10.53	Single	8HK2	C3a anaphylatoxin	8HK2-C3a_B-C3a anaphylatoxin-Gi1/β1/γ2
10.53	Single	8IBU	Erythromycin-A	8IBU-Motilin-Erythromycin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
10.53	Single	8ID9	Eicosapentaenoic acid	8ID9-FFA4-Eicosapentaenoic acid-Gi1/β1/γ2
10.53	Single	8IYW	GSK256073	8IYW-HCA₂-GSK256073-Go/β1/γ2
10.53	Single	8J6D	EP141	8J6D-C3a_B-EP141-Go/β1/γ2
10.53	Single	8JPC	Neurotensin-(8-13)	8JPC-NTS₁-Neurotensin-(8-13)-SBI-553; GDP; Mg-Gq; GRK2
10.53	Single	8JWZ	AB928	8JWZ-A_2A-AB928-Na
10.53	Single	8JZ7	MK6892	8JZ7-HCA₂-MK6892-Gi1/β1/γ2
10.53	Single	8U26	Protachykinin-1	8U26-NK₁-Protachykinin-1-Gs/β1/γ2
10.53	Single	8WRB	Lysophosphatidylserine	8WRB-GPR34-Lysophosphatidylserine-Gi1/β1/γ2
10.53	Single	8X8N	Octreotide	8X8N-SST5-Octreotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
10.53	Single	8XQJ	JN241	8XQJ-Apelin-JN241
10.53	Single	8Y6W	TUG-1375	8Y6W-FFA2-TUG-1375-4-CMTB-Gi1/β1/γ2
10.53	Single	9AU0	BW245C	9AU0-DP₁-BW245C-Gs/β1/γ2
10.53	Single	9DGI	Z8526711350	9DGI-CB₁-Z8526711350
10.53	Single	9EBI	Piclidenoson	9EBI-A_3A-Piclidenoson-chim(NtGi1L-Gs-CtGi1)/β1/γ2
10.53	Single	9GYO	P395	9GYO-GPBA-P395-chim(NtGi1-Gs)/β1/γ2
10.53	Consensus	5ht1f_on	Orthosteric Ligand	7EXD-5-HT_1F-Lasmiditan-Gi1/β1/γ2
10.53	Consensus	5ht1f_on_gp	Orthosteric Ligand	7EXD-5-HT_1F-Lasmiditan-Gi1/β1/γ2
10.53	Consensus	beta3_on	Orthosteric Ligand	7DH5-β₃-Mirabegron-Gs/β1/γ2 7XJH-β₃-Isoproterenol-Gs/β1/γ2 7XJI-β₃-Solabegron-Gs/β1/γ2
10.53	Consensus	beta3_on_gp	Orthosteric Ligand	7DH5-β₃-Mirabegron-Gs/β1/γ2 7XJH-β₃-Isoproterenol-Gs/β1/γ2 7XJI-β₃-Solabegron-Gs/β1/γ2
10.53	Consensus	cannabinoid_off	Orthosteric Ligand	cb2_off cb1_off
10.53	Consensus	ccr8_on	Orthosteric Ligand	8KFX-CCR8-LMD-009-Gi1/β1/γ2 8KFY-CCR8-ZK-756326-Gi1/β1/γ2 8U1U-CCR8-CCL1-Gi1/β1/γ2
10.53	Consensus	ffa2_on_gp	Orthosteric Ligand	8J22-FFA2-TUG-1375-Gi1/β1/γ2
10.53	Consensus	gi_neurotensin	Orthosteric Ligand	6OSA-NTS₁-JMV449-Gi1/β1/γ2 7L0S-NTS₁-Neurotensin-Gi1/β1/γ1
10.53	Consensus	gi_p2y	Orthosteric Ligand	7XXI-P2Y₁₂-2MeSADP-Gi2/β1/γ2
10.53	Consensus	leukotriene_off	Orthosteric Ligand	blt_off cyslt_off
10.53	Consensus	motilin_on_gp	Orthosteric Ligand	8IBU-Motilin-Erythromycin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
10.53	Consensus	neurotensin_on_gp	Orthosteric Ligand	nts1_on_gp
10.53	Consensus	nts1_on_gp	Orthosteric Ligand	6OSA-NTS₁-JMV449-Gi1/β1/γ2 7L0S-NTS₁-Neurotensin-Gi1/β1/γ1
10.53	Consensus	opioid_off	Orthosteric Ligand	mop_off nop_off dop_off kop_off
10.53	Consensus	p2y12_on_gp	Orthosteric Ligand	7XXI-P2Y₁₂-2MeSADP-Gi2/β1/γ2
10.53	Consensus	s1p1_on	Orthosteric Ligand	7VIE-S1P₁-S1P-Gi1/β1/γ2 7VIF-S1P₁-S-FTY720-P-Gi1/β1/γ2 7VIG-S1P₁-CBP-307-Gi1/β1/γ2 7EVY-S1P₁-Siponimod-Gi1/β1/γ2 7EVZ-S1P₁-Cenerimod-Gi1/β1/γ2 7EW0-S1P₁-Ozanimod-Gi1/β1/γ2 7EW7-S1P₁-SEW2871-Gi1/β1/γ2
10.53	Consensus	s1p1_on_gp	Orthosteric Ligand	7VIE-S1P₁-S1P-Gi1/β1/γ2 7VIF-S1P₁-S-FTY720-P-Gi1/β1/γ2 7VIG-S1P₁-CBP-307-Gi1/β1/γ2 7EVY-S1P₁-Siponimod-Gi1/β1/γ2 7EVZ-S1P₁-Cenerimod-Gi1/β1/γ2 7EW0-S1P₁-Ozanimod-Gi1/β1/γ2 7EW7-S1P₁-SEW2871-Gi1/β1/γ2
10.34	Consensus	gi_endothelin	Orthosteric Ligand	8IY5-ET_B-Endothelin-1-Gi1/β1/γ2 8HBD-ET_B-IRL1620-Gi1/β1/γ2
10.34	Consensus	gi_npy	Orthosteric Ligand	8K6M-Y₁-Neuropeptide-Y-Gi2/β1/γ1 7X9C-Y₄-Pancreatic Hormone-Gi1/β1/γ2 7YOO-Y₂-Neuropeptide-Y-Gi1/β1/γ2
10.34	Consensus	npy_on	Orthosteric Ligand	npy1_on npy2_on npy4_on
10.34	Consensus	npy_on_gp	Orthosteric Ligand	npy1_on_gp npy2_on_gp npy4_on_gp
10.00	Single	4BUO	Neurotensin	4BUO-NTS₁-Neurotensin
10.00	Single	4NC3	Ergotamine	4NC3-5-HT_2B-Ergotamine
10.00	Single	5TUD	Ergotamine	5TUD-5-HT_2B-Ergotamine
10.00	Single	6M1H	Maxadilan	6M1H-PAC₁-Maxadilan-Gs/β1/γ2
10.00	Single	6O3C	Cholesterol	6O3C-SMO-SAG21k-Cholesterol
10.00	Single	6RZ9	ONO-2770372	6RZ9-CysLT₂-ONO-2770372
10.00	Single	7CX4	Evatanepag	7CX4-EP₂-Evatanepag-Gs/β1/γ2
10.00	Single	7D7M	Dinoprostone	7D7M-EP₄-Dinoprostone-Gs/β1/γ1
10.00	Single	7EVZ	Cenerimod	7EVZ-S1P₁-Cenerimod-Gi1/β1/γ2
10.00	Single	7EZC	UKA	7EZC-A_2A-UKA
10.00	Single	7EZH	Cholecystokinin-8	7EZH-CCK_A-Cholecystokinin-8-Gi1/β1/γ2
10.00	Single	7EZM	Cholecystokinin-8	7EZM-CCK_A-Cholecystokinin-8-chim(NtGsL-Gq)/β1/γ2
10.00	Single	7FIG	hCG	7FIG-LH-hCG-chim(NtGi1L-Gs)/β1/γ2
10.00	Single	7LLL	Exendin-4	7LLL-GLP-1-Exendin-4-Gs/β1/γ2
10.00	Single	7MTS	ADX55164	7MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/β1/γ2
10.00	Single	7P00	Substance-P	7P00-NK₁-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
10.00	Single	7PIU	Setmelanotide	7PIU-MC₄-Setmelanotide-Gs/β1/γ2
10.00	Single	7QVM	Oxytocin	7QVM-OT-Oxytocin-chim(NtGi1-Go-CtGq)/β1/γ2
10.00	Single	7UTZ	TR1402	7UTZ-TSH-TR1402-DPPC-Gs/β1/γ2
10.00	Single	7X8R	BOC5	7X8R-GLP-1-BOC5-Gs/β1/γ2
10.00	Single	7XJI	Solabegron	7XJI-β₃-Solabegron-Gs/β1/γ2
10.00	Single	7XW5	TSH	7XW5-TSH-TSH-ML109-Gs/β1/γ2
10.00	Single	7ZI0	Cholesterol	7ZI0-SMO-SAG-Cholesterol
10.00	Single	8FN0	Neurotensin/Neuromedin-N	8FN0-NTS₁-Neurotensin/Neuromedin-N-SBI-553-chim(NtGi1-Go)/β1/γ2
10.00	Single	8GAG	PubChem 170838490	8GAG-CB₁-PubChem 170838490-Gi1/β1/γ2
10.00	Single	8HBD	IRL1620	8HBD-ET_B-IRL1620-Gi1/β1/γ2
10.00	Single	8ID8	TUG-891	8ID8-FFA4-TUG-891-Gi1/β1/γ2
10.00	Single	8IJD	MK6892	8IJD-HCA₂-MK6892-Gi1/β1/γ2
10.00	Single	8IUL	Latanoprost	8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/β1/γ2
10.00	Single	8WCB	Cyclohexylammonium Ion	8WCB-TA1-Cyclohexylammonium Ion-chim(NtGi1-Gs-CtGq)/β1/γ2
10.00	Single	8WCC	Cyclohexylammonium Ion	8WCC-TA1-Cyclohexylammonium Ion
10.00	Single	9GG5	U46619	9GG5-TXA2-U46619-chim(NtGi2L-Gs-CtGq)/β1/γ2
10.00	Single	9M1H	Prostaglandin E2	9M1H-EP₁-Prostaglandin E2-chim(NtGi1-Gs-CtGq)/β1/γ2
10.00	Consensus	ccka_on	Orthosteric Ligand	7EZH-CCK_A-Cholecystokinin-8-Gi1/β1/γ2
10.00	Consensus	ccka_on_gp	Orthosteric Ligand	7EZH-CCK_A-Cholecystokinin-8-Gi1/β1/γ2
10.00	Consensus	class-a_on	Orthosteric Ligand	sensory_on alicarboxylic_on amine_on lipid_on nucleotide_on peptide_on protein_on
10.00	Consensus	cyslt2_off	Orthosteric Ligand	6RZ7-CysLT₂-ONO-2570366 6RZ8-CysLT₂-ONO-2080365 6RZ9-CysLT₂-ONO-2770372
10.00	Consensus	etb_on_gp	Orthosteric Ligand	8IY5-ET_B-Endothelin-1-Gi1/β1/γ2 8HBD-ET_B-IRL1620-Gi1/β1/γ2
10.00	Consensus	fp-alpha_on	Orthosteric Ligand	8IUK-FP-alpha-PGF2-α-chim(NtGi1-Gs-CtGq)/β1/γ2 8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/β1/γ2 8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/β1/γ2
10.00	Consensus	fp-alpha_on_gp	Orthosteric Ligand	8IUK-FP-alpha-PGF2-α-chim(NtGi1-Gs-CtGq)/β1/γ2 8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/β1/γ2 8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/β1/γ2
10.00	Consensus	gi_s1p	Orthosteric Ligand	7VIE-S1P₁-S1P-Gi1/β1/γ2 7EW3-S1P₃-S1P-Gi1/β1/γ2 7EVY-S1P₁-Siponimod-Gi1/β1/γ2 7EW1-S1P₅-Siponimod-Gi1/β1/γ2 7VIF-S1P₁-S-FTY720-P-Gi1/β1/γ2 7VIG-S1P₁-CBP-307-Gi1/β1/γ2 7EVZ-S1P₁-Cenerimod-Gi1/β1/γ2 7EW4-S1P₃-CYM5541-Gi1/β1/γ2 7EW2-S1P₃-Fingolimod-Gi1/β1/γ2 7EW0-S1P₁-Ozanimod-Gi1/β1/γ2 7EW7-S1P₁-SEW2871-Gi1/β1/γ2
10.00	Consensus	glp1_on	Orthosteric Ligand	7S1M-GLP-1-Ex4-D-Ala-Gs/β1/γ2 7X8R-GLP-1-BOC5-Gs/β1/γ2 6X19-GLP-1-CHU-128-Gs/β1/γ2 6X1A-GLP-1-Danuglipron-Gs/β1/γ2 6X18-GLP-1-GLP-1-Gs/β1/γ2 8JIP-GLP-1-MEDI0382-chim(NtGi1-Gs)/β1/γ2 7C2E-GLP-1-PubChem 149050799-Gs/β1/γ2 7KI0-GLP-1-Semaglutide-Gs/β1/γ2 7KI1-GLP-1-Taspoglutide-Gs/β1/γ2 7X8S-GLP-1-WB4-24-Gs/β1/γ2 8JIS-GLP-1-Peptide-15-chim(NtGi1-Gs)/β1/γ2 7VBI-GLP-1-Non-Acylated Tirzepatide-Gs/β1/γ2
10.00	Consensus	nk1_on	Orthosteric Ligand	7P00-NK₁-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
10.00	Consensus	nk1_on_gp	Orthosteric Ligand	7P00-NK₁-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
10.00	Consensus	prostanoid_off	Orthosteric Ligand	ep_off dp_off
9.68	Consensus	glp1_on_gp	Orthosteric Ligand	7S1M-GLP-1-Ex4-D-Ala-Gs/β1/γ2 7X8R-GLP-1-BOC5-Gs/β1/γ2 6X19-GLP-1-CHU-128-Gs/β1/γ2 6X1A-GLP-1-Danuglipron-Gs/β1/γ2 6X18-GLP-1-GLP-1-Gs/β1/γ2 8JIP-GLP-1-MEDI0382-chim(NtGi1-Gs)/β1/γ2 7C2E-GLP-1-PubChem 149050799-Gs/β1/γ2 7KI0-GLP-1-Semaglutide-Gs/β1/γ2 7KI1-GLP-1-Taspoglutide-Gs/β1/γ2 7X8S-GLP-1-WB4-24-Gs/β1/γ2 8JIS-GLP-1-Peptide-15-chim(NtGi1-Gs)/β1/γ2 7VBI-GLP-1-Non-Acylated Tirzepatide-Gs/β1/γ2
9.68	Consensus	gs_peptide	Orthosteric Ligand	gs_cck gs_melanocortin gs_vasop-oxy
9.68	Consensus	pth1_on_gp	Orthosteric Ligand	6NBF-PTH1-Long-Acting PTH Analog-Gs/β1/γ2 8HA0-PTH1-PTH-chim(NtGi1-Gs)/β1/γ2 8HAF-PTH1-PTHrP(1-36)-chim(NtGi1-Gs)/β1/γ2 7Y36-PTH1-Teriparatide-Gs/β1/γ2 7Y35-PTH1-Abaloparatide-Gs/β1/γ2
9.52	Single	3NY9	ICI118-551	3NY9-β₂-ICI118-551
9.52	Single	5WF6	UK-432097	5WF6-A_2A-UK-432097
9.52	Single	6G79	Donitriptan	6G79-5-HT_1B-Donitriptan-Go/β1/γ2
9.52	Single	6RZ6	ONO-2570366	6RZ6-CysLT₂-ONO-2570366
9.52	Single	6XBJ	Cholesterol	6XBJ-SMO-Cholesterol-Gi1/β1/γ2
9.52	Single	7AUE	Setmelanotide	7AUE-MC₄-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2
9.52	Single	7CX2	PGE2	7CX2-EP₂-PGE2-Gs/β1/γ2
9.52	Single	7F2O	Bradykinin	7F2O-BK₂-Bradykinin-chim(NtGi1-Gs-CtGq)/β1/γ2
9.52	Single	7RMG	Substance-P	7RMG-NK₁-Substance-P-chim(Gs-CtGq)/β1/γ2
9.52	Single	7RMH	Substance-P	7RMH-NK₁-Substance-P-Gs/β1/γ2
9.52	Single	7S8L	Cortistatin-14	7S8L-MRGPRX2-Cortistatin-14-chim(NtGi2L-Gs-CtGq)/β1/γ2
9.52	Single	7T11	Octreotide	7T11-SST2-Octreotide-Gi3/β1/γ2
9.52	Single	7X8S	WB4-24	7X8S-GLP-1-WB4-24-Gs/β1/γ2
9.52	Single	7Y1F	Dynorphin	7Y1F-κ-Dynorphin-Gi1/β1/γ2
9.52	Single	8GDA	L902688	8GDA-EP₄-L902688-Gs/β1/γ2
9.52	Single	8IQ4	Carboprost	8IQ4-FP-alpha-Carboprost-chim(NtGi1-Gs-CtGq)/β1/γ2
9.52	Single	8IUM	Tafluprost acid	8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/β1/γ2
9.52	Single	8J22	TUG-1375	8J22-FFA2-TUG-1375-Gi1/β1/γ2
9.52	Single	8SAI	1-Oleoyl-2-Hydroxy-Sn-Glycero-3-Phospho-L-Serine	8SAI-GPR34-1-Oleoyl-2-Hydroxy-Sn-Glycero-3-Phospho-L-Serine-Gi1/β1/γ2
9.52	Single	8X3L	XWD	8X3L-CB₂-XWD-Gi1/β1/γ2
9.52	Single	8XQJ	JN241	8XQJ-Apelin-JN241
9.52	Single	8Z74	Agonistic antibody	8Z74-Apelin-Agonistic antibody
9.52	Single	9ITB	LPA	9ITB-LPA₆-LPA-chim(NtGi1-Gs-CtGq)/β1/γ2
9.52	Single	9M0R	Neuropeptide VF	9M0R-NPFF1-Neuropeptide VF-Gi1/β1/γ2
9.52	Consensus	dop_on	Orthosteric Ligand	8F7S-δ-Deltorphin-Gi1/β1/γ2
9.52	Consensus	nmur1_on	Orthosteric Ligand	7W53-NMUR1-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
9.52	Consensus	s1p_on	Orthosteric Ligand	s1p1_on s1p3_on s1p5_on
9.52	Consensus	s1p_on_gp	Orthosteric Ligand	s1p1_on_gp s1p3_on_gp s1p5_on_gp
9.38	Single	7X9A	Neuropeptide-Y	7X9A-Y₁-Neuropeptide-Y-Gi1/β1/γ2
9.38	Consensus	pth2_on	Orthosteric Ligand	7F16-PTH2-TIP39-Gs/β1/γ2
9.09	Single	4IB4	Ergotamine	4IB4-5-HT_2B-Ergotamine
9.09	Single	4XT1	Fractalkine	4XT1-US28-Fractalkine
9.09	Single	5L7D	Cholesterol	5L7D-SMO-Cholesterol
9.09	Single	5MZJ	Theophylline	5MZJ-A_2A-Theophylline-Na
9.09	Single	6RZ8	ONO-2080365	6RZ8-CysLT₂-ONO-2080365
9.09	Single	7CX3	Taprenepag	7CX3-EP₂-Taprenepag-Gs/β1/γ2
9.09	Single	7F4I	SHU9119	7F4I-MC₁-SHU9119-chim(NtGi1-Gs)/β1/γ2
9.09	Single	7QA8	Peptide	7QA8-STE2-Peptide
9.09	Single	7QA8	Peptide	7QA8-STE2-Peptide
9.09	Single	7RTB	Peptide-19	7RTB-GLP-1-Peptide-19-Gs/β1/γ2
9.09	Single	7T9I	TSH	7T9I-TSH-TSH-Gs/β1/γ2
9.09	Single	7TD4	Siponimod	7TD4-S1P₁-Siponimod-Gi1/β1/γ2
9.09	Single	7W53	Neuromedin-U-25	7W53-NMUR1-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
9.09	Single	7WIC	Somatostatin-14	7WIC-SST2-Somatostatin-14-Gi1/β1/γ2
9.09	Single	7XKD	Beta-Hydroxyandrosterone	7XKD-ADGRG2-β-Hydroxyandrosterone-Gs/β1/γ2
9.09	Single	7XKE	Beta-Hydroxyandrosterone	7XKE-ADGRG2-β-Hydroxyandrosterone-chim(NtGi1-Gs)/β1/γ2
9.09	Single	8G59	TUG-891	8G59-FFA4-TUG-891-chim(Gi1-CtGq)/β1/γ2
9.09	Single	8GHV	AMG315	8GHV-CB₁-AMG315-Gi1/β1/γ2
9.09	Single	8HQM	NPGLY	8HQM-GPR132-NPGLY-Gi1/β1/γ2
9.09	Single	8HS2	Fab046	8HS2-GPR20-Fab046
9.09	Single	8HVI	NOX-6-7	8HVI-GPR132-NOX-6-7-Gi1/β1/γ2
9.09	Single	8I2G	Glycoprotein hormones alpha chain	8I2G-FSH-Glycoprotein hormones α chain-Compound 716340-Gs/β1/γ2
9.09	Single	8IEB	A1LYA	8IEB-GPR156-A1LYA
9.09	Single	8IEI	A1LYA	8IEI-GPR156-A1LYA
9.09	Single	8IEP	A1LYA	8IEP-GPR156-A1LYA
9.09	Single	8IEP	A1LYA	8IEP-GPR156-A1LYA
9.09	Single	8INR	Alpha-MSH	8INR-MC₅-α-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
9.09	Single	8J6R	MK6892	8J6R-HCA₂-MK6892-Gi1/β1/γ2
9.09	Single	8JIQ	Peptide-15	8JIQ-Glucagon-Peptide-15-Gs/β1/γ2
9.09	Single	8PWN	Theophylline	8PWN-A_2A-Theophylline
9.09	Single	8WDT	photoNECA	8WDT-A_2A-photoNECA
9.09	Single	8WZ2	Orexigenic Neuropeptide QRFP	8WZ2-QRFP-Orexigenic Neuropeptide QRFP-chim(NtGi1L-Gs-CtGq)/β1/γ2
9.09	Single	8X9S	5alpha-DHT	8X9S-ADGRD1-5α-DHT-chim(NtGi1-Gs)/β1/γ2
9.09	Single	8XBH	S3E-LysoPS	8XBH-GPR34-S3E-LysoPS-Gi1/β1/γ2
9.09	Single	8XGM	Chemerin	8XGM-CML2-Chemerin-Gi1/β1/γ2
9.09	Single	8YWF	Retatrutide	8YWF-GLP-1-Retatrutide-chim(NtGi1-Gs)/β1/γ2
9.09	Single	8ZCJ	Pasireotide	8ZCJ-SST5-Pasireotide-Gi1/β1/γ1
9.09	Single	9BKJ	Cholecystokinin-8	9BKJ-CCK_A-Cholecystokinin-8-chim(NtGi1-Gs-CtGq)/β1/γ2
9.09	Single	9BUE	Cagrilintide	9BUE-CT-Cagrilintide-Gs/β1/γ2
9.09	Single	9BUY	LM189	9BUY-β₂-LM189-Gi1/β1/γ2
9.09	Single	9IV2	5alpha-DHT	9IV2-ADGRD1-5α-DHT-chim(NtGi1-Gs)/β1/γ2
9.09	Single	9L3Y	Retinoic acid receptor responder protein 2	9L3Y-CML2-Retinoic acid receptor responder protein 2-Gi1/β1/γ2
9.09	Consensus	class-a_on_gp	Orthosteric Ligand	sensory_on_gp alicarboxylic_on_gp amine_on_gp lipid_on_gp nucleotide_on_gp peptide_on_gp protein_on_gp
9.09	Consensus	gi_opioid	Orthosteric Ligand	8F7R-μ-Endomorphin-Gi1/β1/γ2 8EF5-μ-Fentanyl-Gi1/β1/γ2 7SCG-μ-FH210-Gi1/β1/γ2 7T2H-μ-Lofentanil-Gi1/β1/γ2 7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2 8DZP-κ-momSalB-Gi1/β1/γ2 8EF6-μ-Morphine-Gi1/β1/γ2 8F7X-NOP-Nociceptin-Gi1/β1/γ2 8EFB-μ-Oliceridine-Gi1/β1/γ2 7U2L-μ-PubChem 163201242-Gi1/β1/γ2 8EFO-μ-PZM21-Gi1/β1/γ2 8EFL-μ-SR17018-Gi1/β1/γ2 8F7Q-μ-β-Endorphin-Gi1/β1/γ2 7U2K-μ-C6-guano-Gi1/β1/γ2 8EFQ-μ-Damgo-Gi1/β1/γ2 8F7S-δ-Deltorphin-Gi1/β1/γ2 8F7W-κ-Dynorphin-Gi1/β1/γ2
9.09	Consensus	mop_off	Orthosteric Ligand	4DKL-μ-β-Funaltrexamine 8QOT-μ-Nanobody-E 7UL4-μ-Alvimopan
9.09	Consensus	nmur1_on_gp	Orthosteric Ligand	7W53-NMUR1-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
9.09	Consensus	sst5_on	Orthosteric Ligand	8X8L-SST5-Cortistatin-chim(NtGi1-Gs-CtGi1)/β1/γ2 8X8N-SST5-Octreotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
8.82	Consensus	mc2_on	Orthosteric Ligand	8GY7-MC₂-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1
8.82	Consensus	mc2_on_gp	Orthosteric Ligand	8GY7-MC₂-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1
8.70	Single	6HLO	Aprepitant	6HLO-NK₁-Aprepitant
8.70	Single	6WHC	Glu16 analog of GCG	6WHC-Glucagon-Glu16 analog of GCG-Gs/β1/γ2
8.70	Single	7DDZ	JNJ-31020028	7DDZ-Y₂-JNJ-31020028
8.70	Single	7EZK	Cholecystokinin-8	7EZK-CCK_A-Cholecystokinin-8-chim(NtGi1-Gs)/β1/γ2
8.70	Single	7TRY	Urocortin	7TRY-CRF₂-Urocortin-chim(NtGi1-G11)/β1/γ2
8.70	Single	7VBI	Non-Acylated Tirzepatide	7VBI-GLP-1-Non-Acylated Tirzepatide-Gs/β1/γ2
8.70	Single	7W0N	Elabela	7W0N-Apelin-Elabela-Gi1/β1/γ2
8.70	Single	7XNA	CYN154806	7XNA-SST2-CYN154806
8.70	Single	8IBV	Motilin	8IBV-Motilin-Motilin-chim(NtGi1-Gs-CtGq)/β1/γ2
8.70	Single	8IEB	A1LYA	8IEB-GPR156-A1LYA
8.70	Single	8IOC	Gamma-MSH	8IOC-MC₃-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
8.70	Single	8JZZ	C5a-desArg	8JZZ-C5a₁-C5a-desArg-Go/β1/γ2
8.70	Single	8K6O	Pro-neuropeptide-Y	8K6O-Y₁-Pro-neuropeptide-Y-Gi2/β1/γ1
8.70	Single	8XYD	Platelet Activating Factor	8XYD-PAF-Platelet Activating Factor-Gi1/β1/γ2
8.70	Single	8Z7J	Agonistic antibody	8Z7J-Apelin-Agonistic antibody-Gi1/β1/γ2
8.70	Single	9E82	SDF-1-beta	9E82-ACKR3-SDF-1-β-Arrestin2
8.70	Single	9EAI	Nanobody AT209	9EAI-AT₁-Losartan-Nanobody AT209
8.70	Single	9IQR	Muscarinic toxin 3	9IQR-α_2a-Muscarinic toxin 3
8.70	Single	9IQS	Muscarinic toxin 3	9IQS-M₄-Muscarinic toxin 3
8.70	Consensus	ccr8_on_gp	Orthosteric Ligand	8KFX-CCR8-LMD-009-Gi1/β1/γ2 8KFY-CCR8-ZK-756326-Gi1/β1/γ2 8U1U-CCR8-CCL1-Gi1/β1/γ2
8.70	Consensus	gq_class-a	Orthosteric Ligand	gq_peptide gq_amine gq_nucleotide
8.70	Consensus	mc5_on	Orthosteric Ligand	8INR-MC₅-α-MSH-Ca-chim(NtGi1-Gs)/β1/γ2 8IOD-MC₅-PG-901-Ca-chim(NtGi1-Gs)/β1/γ2
8.70	Consensus	npy2_off	Orthosteric Ligand	7DDZ-Y₂-JNJ-31020028
8.70	Consensus	s1p3_on_gp	Orthosteric Ligand	7EW3-S1P₃-S1P-Gi1/β1/γ2 7EW4-S1P₃-CYM5541-Gi1/β1/γ2 7EW2-S1P₃-Fingolimod-Gi1/β1/γ2
8.70	Consensus	sst2_off	Orthosteric Ligand	7XNA-SST2-CYN154806
8.70	Consensus	sst4_on	Orthosteric Ligand	7XMS-SST4-Somatostatin-14-Gi1/β1/γ2 7XMT-SST4-J-2156-Gi1/β1/γ2
8.70	Consensus	sst4_on_gp	Orthosteric Ligand	7XMS-SST4-Somatostatin-14-Gi1/β1/γ2 7XMT-SST4-J-2156-Gi1/β1/γ2
8.70	Consensus	tachykinin_on_gp	Orthosteric Ligand	nk1_on_gp nk2_on_gp nk3_on_gp
8.57	Consensus	pth2_on_gp	Orthosteric Ligand	7F16-PTH2-TIP39-Gs/β1/γ2
8.33	Single	3RFM	Caffeine	3RFM-A_2A-Caffeine
8.33	Single	5WF5	UK-432097	5WF5-A_2A-UK-432097
8.33	Single	6UUN	Adrenomedullin	6UUN-CT Like (AM1)-Adrenomedullin-Gs/β1/γ2; RAMP2
8.33	Single	7F4D	Alpha-MSH	7F4D-MC₁-α-MSH-chim(NtGi1-Gs)/β1/γ2
8.33	Single	7MBX	Cholecystokinin-8	7MBX-CCK_A-Cholecystokinin-8-Gs/β1/γ1
8.33	Single	7VDM	Substance-P	7VDM-MRGPRX2-Substance-P-Gi1/β1/γ2
8.33	Single	8A2O	Theophylline	8A2O-A_2A-Theophylline-Na
8.33	Single	8K6M	Neuropeptide-Y	8K6M-Y₁-Neuropeptide-Y-Gi2/β1/γ1
8.33	Single	8W8Y	Gamma-MSH	8W8Y-MC₃-γ-MSH-Ca-Gs/β1/γ2
8.33	Single	8XIQ	L796778	8XIQ-SST3-L796778-chim(NtGi1-Gs-CtGi1)/β1/γ2
8.33	Single	8XZG	Apelin-13	8XZG-Apelin-Apelin-13-Gi1/β1/γ2
8.33	Single	8XZH	MM07	8XZH-Apelin-MM07-Gi1/β1/γ2
8.33	Single	9B54	A1AIW	9B54-CB₁-A1AIW-Gi1/β1/γ2
8.33	Single	9IVM	GLP-1 (Truncated)	9IVM-GLP-1-GLP-1 (Truncated)-LSN3318839-chim(NtGi1-Gs)/β2/γ2
8.33	Single	9K27	PrRP31	9K27-PrRP-PrRP31-chim(NtGi1-Gq)/β1/γ2
8.33	Consensus	class-b1_class-b2_cons_on	Orthosteric Ligand	class-b1_on class-b2_on
8.33	Consensus	class-b1_class-b2_cons_on_gp	Orthosteric Ligand	class-b1_on_gp class-b2_on_gp
8.33	Consensus	gi_somatostatin	Orthosteric Ligand	7WIC-SST2-Somatostatin-14-Gi1/β1/γ2 7XMS-SST4-Somatostatin-14-Gi1/β1/γ2 8X8L-SST5-Cortistatin-chim(NtGi1-Gs-CtGi1)/β1/γ2 7XMT-SST4-J-2156-Gi1/β1/γ2 7WIG-SST2-L-054,264-Gi1/β1/γ2 8X8N-SST5-Octreotide-chim(NtGi1-Gs-CtGi1)/β1/γ2 7YAE-SST2-Octreotide-Gi1/β1/γ2 7YAC-SST2-Paltusotine-Gi1/β1/γ2
8.33	Consensus	gs_cck	Orthosteric Ligand	7MBX-CCK_A-Cholecystokinin-8-Gs/β1/γ1
8.33	Consensus	gs_class-a	Orthosteric Ligand	gs_peptide gs_nucleotide gs_amine
8.33	Consensus	mc3_on	Orthosteric Ligand	8IOC-MC₃-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
8.33	Consensus	mc3_on_gp	Orthosteric Ligand	8IOC-MC₃-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
8.33	Consensus	npy1_on	Orthosteric Ligand	8K6M-Y₁-Neuropeptide-Y-Gi2/β1/γ1
8.33	Consensus	npy1_on_gp	Orthosteric Ligand	8K6M-Y₁-Neuropeptide-Y-Gi2/β1/γ1
8.33	Consensus	somatostatin_on	Orthosteric Ligand	sst2_on sst4_on sst5_on
8.33	Consensus	somatostatin_on_gp	Orthosteric Ligand	sst2_on_gp sst4_on_gp sst5_on_gp
8.00	Single	6M1I	PACAP	6M1I-PAC₁-PACAP-Gs/β1/γ2
8.00	Single	6WI9	Secretin	6WI9-Secretin-Secretin-Gs/β1/γ2
8.00	Single	7F4H	Afamelanotide	7F4H-MC₁-Afamelanotide-chim(NtGi1-Gs)/β1/γ2
8.00	Single	7FIM	Tirzepatide	7FIM-GLP-1-Tirzepatide-Gs/β1/γ2
8.00	Single	7FIN	Peptide-20; GGL	7FIN-GIP-Peptide-20; GGL-Gs/β1/γ2
8.00	Single	7T10	Somatostatin-14	7T10-SST2-Somatostatin-14-Gi3/β1/γ2
8.00	Single	7TYI	Amylin	7TYI-CT-Amylin-Gs/β1/γ2
8.00	Single	7WUI	IP15	7WUI-ADGRG2-IP15-chim(NtGi1-Gs)/β1/γ2
8.00	Single	8HA0	PTH	8HA0-PTH1-PTH-chim(NtGi1-Gs)/β1/γ2
8.00	Single	8IED	A1LYA	8IED-GPR156-A1LYA-Go/β1/γ2
8.00	Single	8IED	A1LYA	8IED-GPR156-A1LYA-Go/β1/γ2
8.00	Single	8WST	Pro-MCH	8WST-MCH2-Pro-MCH-chim(NtGi1L-Gs-CtGq)/β1/γ2
8.00	Single	8XWQ	Endothelin-1	8XWQ-ET_B-Endothelin-1-Gi1/β1/γ2
8.00	Single	8YW3	Retatrutide	8YW3-GLP-1-Retatrutide-Gs/β1/γ2
8.00	Single	8YW4	Retatrutide	8YW4-GIP-Retatrutide-chim(NtGi1-Gs)/β1/γ2
8.00	Single	8YW5	Retatrutide	8YW5-Glucagon-Retatrutide-Gs/β1/γ2
8.00	Single	8ZBI	Somatostatin-14	8ZBI-SST3-Somatostatin-14-Gi1/β1/γ2
8.00	Single	9BKK	Cholecystokinin-8	9BKK-CCK_A-Cholecystokinin-8-chim(NtGi1-Gs-CtGq)/β1/γ2
8.00	Single	9BLC	Cagrilintide backbone (non-acylated)	9BLC-CT-Cagrilintide backbone (non-acylated)-Gs/β1/γ2
8.00	Single	9BUD	Cagrilintide	9BUD-CT-Cagrilintide-Gs/β1/γ2
8.00	Single	9EBO	GLP-1 (ACPC18)	9EBO-GLP-1-GLP-1 (ACPC18)-Gs/β1/γ2
8.00	Consensus	gi_formylpeptide	Orthosteric Ligand	7WVY-FPR2-ALX-Amyloid-β42-Gi2/β1/γ2 7T6U-FPR2-ALX-CGEN-855A-Gi1/β1/γ2 7VFX-FPR1-ALX-fMLF-Gi1/β1/γ2 7T6V-FPR2-ALX-fMLFII-Gi1/β1/γ2 7WVX-FPR2-ALX-Humanin-Gi2/β1/γ2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/β1/γ2 6OMM-FPR2-ALX-WKYMVX-Gi1/β1/γ2
8.00	Consensus	mc5_on_gp	Orthosteric Ligand	8INR-MC₅-α-MSH-Ca-chim(NtGi1-Gs)/β1/γ2 8IOD-MC₅-PG-901-Ca-chim(NtGi1-Gs)/β1/γ2
8.00	Consensus	tachykinin_on	Orthosteric Ligand	nk1_on nk2_on nk3_on
7.69	Single	2J4Y	11-cis-Retinal	2J4Y-Rhodopsin-11-cis-Retinal
7.69	Single	3OE6	IT1t	3OE6-CXCR4-IT1t
7.69	Single	3UZA	GTPL9236	3UZA-A_2A-GTPL9236
7.69	Single	5WKT	Octyl-Beta-D-Glucopyranoside	5WKT-Rhodopsin-Octyl-β-D-Glucopyranoside-Gt(CT)
7.69	Single	5YQZ	Glucagon analogue	5YQZ-Glucagon-Glucagon analogue
7.69	Single	6FK9	PubChem 132473036	6FK9-Rhodopsin-PubChem 132473036
7.69	Single	6ME5	Agomelatine	6ME5-MT₁-Agomelatine
7.69	Single	6OIK	LY2119620	6OIK-M₂-Iperoxo-LY2119620-chim(NtGi1-Go)/β1/γ2
7.69	Single	6PWC	Neurotensin	6PWC-NTS₁-Neurotensin-Arrestin2
7.69	Single	6X18	GLP-1	6X18-GLP-1-GLP-1-Gs/β1/γ2
7.69	Single	7F23	Dopamine	7F23-D₁-Dopamine-GDP-Gs/β1/γ2
7.69	Single	7LLY	Oxyntomodulin	7LLY-GLP-1-Oxyntomodulin-Gs/β1/γ2
7.69	Single	7MT8	All-trans-Retinal	7MT8-Rhodopsin-All-trans-Retinal-GRK1
7.69	Single	7MT9	All-trans-Retinal	7MT9-Rhodopsin-All-trans-Retinal-GRK1
7.69	Single	7MTA	All-trans-Retinal	7MTA-Rhodopsin-All-trans-Retinal-GRK1
7.69	Single	7QBI	Alpha-factor mating pheromone	7QBI-STE2-α-factor mating pheromone
7.69	Single	7TYH	Calcitonin-1	7TYH-CT (AMY2)-Calcitonin-1-Gs/β1/γ2; RAMP2
7.69	Single	7TYW	Calcitonin-1	7TYW-CT (AMY1)-Calcitonin-1-Gs/β1/γ2; RAMP1
7.69	Single	7WBJ	PACAP27	7WBJ-VPAC₁-PACAP27-Gs/β1/γ2
7.69	Single	7WC5	Psilocin	7WC5-5-HT_2A-Psilocin
7.69	Single	7X9B	Neuropeptide-Y	7X9B-Y₂-Neuropeptide-Y-Gi1/β1/γ2
7.69	Single	7X9C	Pancreatic Hormone	7X9C-Y₄-Pancreatic Hormone-Gi1/β1/γ2
7.69	Single	7Y35	Abaloparatide	7Y35-PTH1-Abaloparatide-Gs/β1/γ2
7.69	Single	8E3Y	PACAP27	8E3Y-VPAC₁-PACAP27-Gs/β1/γ2
7.69	Single	8E3Z	VIP	8E3Z-VPAC₁-VIP-Gs/β1/γ2
7.69	Single	8EIT	Doconexent	8EIT-FFA1-Doconexent-chim(NtGi1L-Gs-CtGq)/β1/γ2
7.69	Single	8HCQ	Endothelin-1	8HCQ-ET_A-Endothelin-1-chim(NtGi1-Gs-CtGq)/β1/γ2
7.69	Single	8IA2	C5a anaphylatoxin	8IA2-C5a₁-C5a anaphylatoxin-Go/β1/γ2
7.69	Single	8IU2	Retinal	8IU2-Opsin1LW-Retinal-Gi1/β1/γ2
7.69	Single	8J21	Butyric acid	8J21-FFA3-Butyric acid-Gi1/β1/γ2
7.69	Single	8J24	Acetic acid	8J24-FFA2-Acetic acid-Gi1/β1/γ2
7.69	Single	8J6Q	Beta-Hydroxybutyrate	8J6Q-HCA₂-β-Hydroxybutyrate-Compound 9n-Gi1/β1/γ2
7.69	Single	8JRV	Glucagon	8JRV-Glucagon-Glucagon-Arrestin2
7.69	Single	8RQL	Flufenamic acid	8RQL-TAS2R14-Flufenamic acid-Flufenamic acid-chim(NtGi1-Gt3)/β1/γ2
7.69	Single	8WC6	2-Phenylethylamine	8WC6-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/β1/γ2
7.69	Single	8X9U	Metenolone	8X9U-ADGRD1-Metenolone-chim(NtGi1-Gs)/β1/γ2
7.69	Single	8XQE	Apelin-13	8XQE-Apelin-Apelin-13-Gi1/β1/γ2
7.69	Single	8Y63	C20:0 Ceramide	8Y63-FPR2-ALX-C20:0 Ceramide-Gi1/β1/γ2
7.69	Single	8ZRT	ET-1	8ZRT-ET_B-ET-1
7.69	Single	9IV1	5alpha-DHT	9IV1-ADGRD1-5α-DHT-chim(NtGi1-Gs)/β1/γ2
7.69	Single	9JHJ	C18:0 Ceramide	9JHJ-FPR2-ALX-C18:0 Ceramide-Gi1/β1/γ2
7.69	Consensus	calcitonin_on	Orthosteric Ligand	ctlike_on
7.69	Consensus	eta_on	Orthosteric Ligand	8HCQ-ET_A-Endothelin-1-chim(NtGi1-Gs-CtGq)/β1/γ2
7.69	Consensus	eta_on_gp	Orthosteric Ligand	8HCQ-ET_A-Endothelin-1-chim(NtGi1-Gs-CtGq)/β1/γ2
7.69	Consensus	ffa3_on	Orthosteric Ligand	8J21-FFA3-Butyric acid-Gi1/β1/γ2
7.69	Consensus	ffa3_on_gp	Orthosteric Ligand	8J21-FFA3-Butyric acid-Gi1/β1/γ2
7.69	Consensus	gi_apelin	Orthosteric Ligand	8XZH-Apelin-MM07-Gi1/β1/γ2 7W0M-Apelin-PubChem 122701908-Gi1/β1/γ2 8XZJ-Apelin-WN353-Gi1/β1/γ2 8XZF-Apelin-WN561-Gi1/β1/γ2 8XZG-Apelin-Apelin-13-Gi1/β1/γ2
7.69	Consensus	gi_opsins	Orthosteric Ligand	8IU2-Opsin1LW-Retinal-Gi1/β1/γ2
7.69	Consensus	gi_sensory	Orthosteric Ligand	gi_opsins
7.69	Consensus	mc1_on	Orthosteric Ligand	7F4H-MC₁-Afamelanotide-chim(NtGi1-Gs)/β1/γ2 7F4D-MC₁-α-MSH-chim(NtGi1-Gs)/β1/γ2 7F4I-MC₁-SHU9119-chim(NtGi1-Gs)/β1/γ2
7.69	Consensus	mc1_on_gp	Orthosteric Ligand	7F4H-MC₁-Afamelanotide-chim(NtGi1-Gs)/β1/γ2 7F4D-MC₁-α-MSH-chim(NtGi1-Gs)/β1/γ2 7F4I-MC₁-SHU9119-chim(NtGi1-Gs)/β1/γ2
7.69	Consensus	neuromedin-u_on_gp	Orthosteric Ligand	nmur1_on_gp nmur2_on_gp
7.69	Consensus	opsin1lw_on	Orthosteric Ligand	8IU2-Opsin1LW-Retinal-Gi1/β1/γ2
7.69	Consensus	opsin1lw_on_gp	Orthosteric Ligand	8IU2-Opsin1LW-Retinal-Gi1/β1/γ2
7.69	Consensus	pac_on	Orthosteric Ligand	pac1_on
7.69	Consensus	sst5_on_gp	Orthosteric Ligand	8X8L-SST5-Cortistatin-chim(NtGi1-Gs-CtGi1)/β1/γ2 8X8N-SST5-Octreotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
7.69	Consensus	vpac1_on	Orthosteric Ligand	8E3Z-VPAC₁-VIP-Gs/β1/γ2
7.69	Consensus	vpac_on	Orthosteric Ligand	vpac1_on vpac2_on
7.50	Single	8GY7	Corticotropin	8GY7-MC₂-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1
7.41	Single	6FJ3	PTH	6FJ3-PTH1-PTH
7.41	Single	6NBF	Long-Acting PTH Analog	6NBF-PTH1-Long-Acting PTH Analog-Gs/β1/γ2
7.41	Single	6NBI	Long-Acting PTH Analog	6NBI-PTH1-Long-Acting PTH Analog-Gs/β1/γ2
7.41	Single	7KI0	Semaglutide	7KI0-GLP-1-Semaglutide-Gs/β1/γ2
7.41	Single	7QBI	Alpha-factor mating pheromone	7QBI-STE2-α-factor mating pheromone
7.41	Single	7RA3	GIP	7RA3-GIP-GIP-chim(NtGi1-Gs)/β1/γ2
7.41	Single	7RGP	Tirzepatide	7RGP-GLP-1-Tirzepatide-chim(NtGi1-Gs)/β1/γ2
7.41	Single	7VAB	Non-Acylated Tirzepatide	7VAB-GIP-Non-Acylated Tirzepatide-chim(NtGi1-Gs)/β1/γ2
7.41	Single	8E3X	PACAP27	8E3X-PAC₁-PACAP27-Gs/β1/γ2
7.41	Single	8FLR	PTHrP(1-36)	8FLR-PTH1-PTHrP(1-36)-Gs/β1/γ2
7.41	Single	8JIS	Peptide-15	8JIS-GLP-1-Peptide-15-chim(NtGi1-Gs)/β1/γ2
7.41	Single	9BLB	Cagrilintide backbone (non-acylated)	9BLB-CT-Cagrilintide backbone (non-acylated)-Gs/β1/γ2
7.41	Single	9BLW	Cagrilintide backbone (non-acylated)	9BLW-CT (AMY1)-Cagrilintide backbone (non-acylated)-Gs/β1/γ2; RAMP1
7.41	Single	9BP3	Cagrilintide	9BP3-CT (AMY1)-Cagrilintide-Gs/β1/γ2; RAMP1
7.41	Single	9BUB	Cagrilintide	9BUB-CT-Cagrilintide-Gs/β1/γ2
7.41	Single	9J1P	g1:Ox	9J1P-GLP-1-g1:Ox-chim(NtGi1-Gs)/β1/γ2
7.41	Single	9KFK	Relaxin-3	9KFK-RXFP4-Relaxin-3-Gi2/β1/γ2
7.41	Consensus	calcitonin_on_gp	Orthosteric Ligand	ctlike_on_gp
7.41	Consensus	npy4_on	Orthosteric Ligand	7X9C-Y₄-Pancreatic Hormone-Gi1/β1/γ2
7.41	Consensus	npy4_on_gp	Orthosteric Ligand	7X9C-Y₄-Pancreatic Hormone-Gi1/β1/γ2
7.41	Consensus	pac_on_gp	Orthosteric Ligand	pac1_on_gp
7.41	Consensus	vpac1_on_gp	Orthosteric Ligand	8E3Z-VPAC₁-VIP-Gs/β1/γ2
7.41	Consensus	vpac_on_gp	Orthosteric Ligand	vpac1_on_gp vpac2_on_gp
7.14	Single	3OE9	IT1t	3OE9-CXCR4-IT1t
7.14	Single	5NX2	GLP-1 (Truncated)	5NX2-GLP-1-GLP-1 (Truncated)
7.14	Single	6B3J	Exendin-P5	6B3J-GLP-1-Exendin-P5-Gs/β1/γ2
7.14	Single	6FK6	PubChem 132473033	6FK6-Rhodopsin-PubChem 132473033
7.14	Single	6HLL	CP99994	6HLL-NK₁-CP99994
7.14	Single	6PGS	Geraniol	6PGS-Rhodopsin-Geraniol-Gt(CT)
7.14	Single	6TQ4	PubChem 16046844	6TQ4-OX₁-PubChem 16046844-Na
7.14	Single	6UVA	Adrenomedullin-2	6UVA-CT Like (AM2)-Adrenomedullin-2-Gs/β1/γ2; RAMP3
7.14	Single	6VCB	GLP-1	6VCB-GLP-1-GLP-1-LSN3160440-Gs/β1/γ2
7.14	Single	7AD3	Alpha-factor mating pheromone	7AD3-STE2-α-factor mating pheromone-Gi1/STE4/γ2
7.14	Single	7DD5	Ca; Ca; Tryptophan; NPS-2143	7DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
7.14	Single	7DTY	GIP	7DTY-GIP-GIP-Gs/β1/γ2
7.14	Single	7EIB	Des-Arg10-Kallidin	7EIB-BK₁-Des-Arg10-Kallidin-chim(NtGi1-Gs-CtGq)/β1/γ2
7.14	Single	7FIY	Tirzepatide	7FIY-GIP-Tirzepatide-Gs/β1/γ2
7.14	Single	7QBC	Alpha-factor mating pheromone	7QBC-STE2-α-factor mating pheromone
7.14	Single	7S1M	Ex4-D-Ala	7S1M-GLP-1-Ex4-D-Ala-Gs/β1/γ2
7.14	Single	7TRP	LY2033298	7TRP-M₄-Iperoxo-LY2033298-Gi1/β1/γ2
7.14	Single	7TYF	Amylin	7TYF-CT (AMY1)-Amylin-Gs/β1/γ2; RAMP1
7.14	Single	7TYN	Calcitonin-1	7TYN-CT-Calcitonin-1-Gs/β1/γ2
7.14	Single	7UL2	SR48692	7UL2-NTS₁-SR48692-Na
7.14	Single	7VQX	PACAP27	7VQX-VPAC₁-PACAP27-Gs/β1/γ2
7.14	Single	7VUI	JNJ-63533054	7VUI-GPR139-JNJ-63533054-GTP-chim(Gs-CtGq)/β1/γ2
7.14	Single	7VVK	PTH	7VVK-PTH1-PTH-Gs/β1/γ2
7.14	Single	7WVY	Amyloid-Beta42	7WVY-FPR2-ALX-Amyloid-β42-Gi2/β1/γ2
7.14	Single	7XKF	Beta-Hydroxyandrosterone	7XKF-ADGRG2-β-Hydroxyandrosterone-Gs/β1/γ2
7.14	Single	7XT9	Serotonin	7XT9-5-HT₄-Serotonin-Gs/β1/γ2
7.14	Single	7XTA	Serotonin	7XTA-5-HT₄-Serotonin-Gi1/β1/γ2
7.14	Single	8A2P	LUAA47070	8A2P-A_2A-LUAA47070-Na
7.14	Single	8FEG	(DNCP)-Beta-Naloxamine	8FEG-κ-(DNCP)-β-Naloxamine-Gi1/β1/γ2
7.14	Single	8FU6	Glucagon derivative ZP3780	8FU6-Glucagon-Glucagon derivative ZP3780-Gs/β1/γ2
7.14	Single	8H2G	Niacin	8H2G-HCA₂-Niacin-Gi1/β1/γ2
7.14	Single	8HAO	PTH	8HAO-PTH1-PTH-chim(NtGi1-Gs)/β1/γ2
7.14	Single	8HSC	Fab046	8HSC-GPR20-Fab046-Gi1/β1/γ2
7.14	Single	8JLO	Ulotaront	8JLO-TA1-Ulotaront-Gs/β1/γ2
7.14	Single	8K5B	Niacin	8K5B-HCA₂-Niacin
7.14	Single	8SZF	Ca; Ca; Tryptophan; Cinacalcet; PO4; Spermine	8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; Spermine
7.14	Single	8W89	PEA	8W89-TA1-PEA-chim(NtGi1L-Gs)/β1/γ2
7.14	Single	8W8W	Alpha-MSH	8W8W-MC₃-α-MSH-Ca-Gs/β1/γ2
7.14	Single	8XWP	Endothelin-1	8XWP-ET_B-Endothelin-1-Gi1/β1/γ2
7.14	Single	8YH3	N-methyladenosine	8YH3-A_3A-N-methyladenosine-Gi1/β1/γ2
7.14	Single	8ZJG	Chemerin	8ZJG-CML1-Chemerin-Gi1/β1/γ2
7.14	Single	8ZSV	RO5263397	8ZSV-TA1-RO5263397-chim(NtGi1-Gs)/β1/γ2
7.14	Single	9BUC	Cagrilintide	9BUC-CT-Cagrilintide-Gs/β1/γ2
7.14	Single	9C1P	Ca; Tryptophan; '6218; PO4	9C1P-CaS-Ca-Ca; Tryptophan; '6218; PO4
7.14	Single	9IQT	Niacin	9IQT-HCA₂-Niacin-Gi1/β1/γ2
7.14	Single	9IZD	CHBA	9IZD-HCA₁-CHBA-Gi1/β1/γ2
7.14	Single	9K26	PrRP31	9K26-PrRP-PrRP31-Gi1/β1/γ2
7.14	Single	9L3Z	LRH7-C2	9L3Z-CML1-LRH7-C2
7.14	Consensus	5ht4_on	Orthosteric Ligand	7XTA-5-HT₄-Serotonin-Gi1/β1/γ2
7.14	Consensus	5ht4_on_gp	Orthosteric Ligand	7XTA-5-HT₄-Serotonin-Gi1/β1/γ2
7.14	Consensus	crf_on	Orthosteric Ligand	crf2_on crf1_on
7.14	Consensus	glp2_on	Orthosteric Ligand	7D68-GLP-2-GLP-2-Gs/β1/γ2
7.14	Consensus	glp2_on_gp	Orthosteric Ligand	7D68-GLP-2-GLP-2-Gs/β1/γ2
7.14	Consensus	glp_on	Orthosteric Ligand	glp1_on glp2_on
7.14	Consensus	glp_on_gp	Orthosteric Ligand	glp1_on_gp glp2_on_gp
7.14	Consensus	gq_peptide	Orthosteric Ligand	gq_cck gq_kisspeptin gq_bradykinin gq_bombesin gq_angiotensin
7.14	Consensus	neurotensin_off	Orthosteric Ligand	nts1_off
7.14	Consensus	nts1_off	Orthosteric Ligand	7UL2-NTS₁-SR48692-Na
7.14	Consensus	peptide_on	Orthosteric Ligand	cck_on angiotensin_on apelin_on bombesin_on bradykinin_on compl-peptide_on endothelin_on formylpeptide_on galanin_on ghrelin_on kisspeptin_on melanocortin_on motilin_on neuromedin-u_on npy_on neurotensin_on opioid_on orexin_on relaxin_on somatostatin_on tachykinin_on trh_on vasop-oxy_on
7.14	Consensus	peptide_on_gp	Orthosteric Ligand	cck_on_gp angiotensin_on_gp apelin_on_gp bombesin_on_gp bradykinin_on_gp compl-peptide_on_gp endothelin_on_gp formylpeptide_on_gp galanin_on_gp ghrelin_on_gp kisspeptin_on_gp melanocortin_on_gp motilin_on_gp neuromedin-u_on_gp npy_on_gp neurotensin_on_gp opioid_on_gp orexin_on_gp relaxin_on_gp somatostatin_on_gp tachykinin_on_gp trh_on_gp vasop-oxy_on_gp
6.90	Single	6LMK	Glucagon	6LMK-Glucagon-Glucagon-Gs/β1/γ2
6.90	Single	6LML	Glucagon	6LML-Glucagon-Glucagon-Gi1/β1/γ1
6.90	Single	6NBH	Long-Acting PTH Analog	6NBH-PTH1-Long-Acting PTH Analog-Gs/β1/γ2
6.90	Single	6UUS	Adrenomedullin	6UUS-CT Like (AM2)-Adrenomedullin-Gs/β1/γ2; RAMP3
6.90	Single	6WZG	Secretin	6WZG-Secretin-Secretin-Gs/β1/γ2
6.90	Single	7D68	GLP-2	7D68-GLP-2-GLP-2-Gs/β1/γ2
6.90	Single	7KI1	Taspoglutide	7KI1-GLP-1-Taspoglutide-Gs/β1/γ2
6.90	Single	7QBC	Alpha-factor mating pheromone	7QBC-STE2-α-factor mating pheromone
6.90	Single	7TS0	Urocortin	7TS0-CRF₂-Urocortin-chim(NtGi1L-Go)/β1/γ2
6.90	Single	7TYL	Amylin	7TYL-CT-Amylin-Gs/β1/γ2
6.90	Single	7VGX	Neuropeptide-Y	7VGX-Y₁-Neuropeptide-Y-Gi1/β1/γ2
6.90	Single	7VVJ	PTHrP(1-36)	7VVJ-PTH1-PTHrP(1-36)-Gs/β1/γ2
6.90	Single	7VVL	PTH	7VVL-PTH1-PTH-Gs/β1/γ2
6.90	Single	8F0K	Pramlintide Analogue San385	8F0K-CT (AMY3)-Pramlintide Analogue San385-Gs/β1/γ2; RAMP3
6.90	Single	8HAF	PTHrP(1-36)	8HAF-PTH1-PTHrP(1-36)-chim(NtGi1-Gs)/β1/γ2
6.90	Single	9BQ3	Cagrilintide	9BQ3-CT (AMY2)-Cagrilintide-Gs/β1/γ2; RAMP2
6.90	Single	9BTW	Cagrilintide	9BTW-CT (AMY3)-Cagrilintide-Gs/β1/γ2; RAMP3
6.90	Single	9BYO	Exendin-3	9BYO-GLP-1-Exendin-3-Gs/β1/γ2
6.90	Consensus	vip-pacap_on	Orthosteric Ligand	vpac_on pac_on
6.90	Consensus	vip-pacap_on_gp	Orthosteric Ligand	vpac_on_gp pac_on_gp
6.90	Consensus	vpac2_on	Orthosteric Ligand	7VQX-VPAC₁-PACAP27-Gs/β1/γ2
6.90	Consensus	vpac2_on_gp	Orthosteric Ligand	7VQX-VPAC₁-PACAP27-Gs/β1/γ2
6.67	Single	2X72	All-trans-Retinal	2X72-Rhodopsin-All-trans-Retinal-Gt(CT)
6.67	Single	3ODU	IT1t	3ODU-CXCR4-IT1t
6.67	Single	4MQT	LY2119620	4MQT-M₂-Iperoxo-LY2119620
6.67	Single	5OLO	Tozadenant	5OLO-A_2A-Tozadenant-Na
6.67	Single	5OLV	LUAA41063	5OLV-A_2A-LUAA41063-Na
6.67	Single	6DS0	Ly266097	6DS0-5-HT_2B-Ly266097
6.67	Single	6ME2	Ramelteon	6ME2-MT₁-Ramelteon
6.67	Single	6ME9	Ramelteon	6ME9-MT₂-Ramelteon
6.67	Single	6NWE	Octyl-Beta-D-Glucopyranoside	6NWE-Rhodopsin-Octyl-β-D-Glucopyranoside-Gt(CT)
6.67	Single	6OYA	All-trans-Retinal	6OYA-Rhodopsin-All-trans-Retinal-Gt/β1/γ1
6.67	Single	6TQ6	PubChem 145714283	6TQ6-OX₁-PubChem 145714283
6.67	Single	7BR3	Elagolix	7BR3-GnRH₁-Elagolix
6.67	Single	7DUQ	GLP-1	7DUQ-GLP-1-GLP-1-PubChem 156022738-Gs/β1/γ2
6.67	Single	7F1O	Dopamine	7F1O-D₁-Dopamine-GDP; Mg-Gs/β1/γ2
6.67	Single	7LCJ	Danuglipron	7LCJ-GLP-1-Danuglipron
6.67	Single	7LD4	Adenosine	7LD4-A₁-Adenosine-Gi2/β1/γ2
6.67	Single	7M3F	Ca; Ca; Tryptophan; Cinacalcet; PO4	7M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
6.67	Single	7RBT	Tirzepatide	7RBT-GIP-Tirzepatide-LSN3556672-chim(NtGi1-Gs)/β1/γ2
6.67	Single	7SIL	Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4	7SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
6.67	Single	7SIL	Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4	7SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
6.67	Single	7TYX	Amylin	7TYX-CT (AMY2)-Amylin-Gs/β1/γ2; RAMP2
6.67	Single	7VIH	CBP-307	7VIH-S1P₁-CBP-307-Gi1/β1/γ2
6.67	Single	7VUJ	JNJ-63533054	7VUJ-GPR139-JNJ-63533054-GDP-chim(Gs-CtGq)/β1/γ2
6.67	Single	7W0O	Elabela	7W0O-Apelin-Elabela-Gi1/β1/γ2
6.67	Single	7XJJ	Galanin	7XJJ-GAL₁-Galanin-Go/β1/γ2
6.67	Single	7XT8	Serotonin	7XT8-5-HT₄-Serotonin-Gs/β1/γ2
6.67	Single	8GNG	Istradefylline	8GNG-A_2A-Istradefylline
6.67	Single	8H8J	Lodoxamide	8H8J-GPR35-Lodoxamide-Ca-chim(NtGi1L-G13)/β1/γ2
6.67	Single	8J20	Valeric acid	8J20-FFA3-Valeric acid-AR420626-Gi1/β1/γ2
6.67	Single	8JPP	Succinic acid	8JPP-Succinate-Succinic acid-chim(Gs-CtGq)/β1/γ1
6.67	Single	8JSO	AMPH	8JSO-TA1-AMPH-chim(NtGi1-Gs)/β1/γ2
6.67	Single	8T3S	Butyric acid	8T3S-FFA2-Butyric acid-chim(NtGi2L-Gs-CtGq)/β1/γ2
6.67	Single	8T3V	Docosa-4,7,10,13,16,19-Hexaenoic acid	8T3V-FFA1-Docosa-4,7,10,13,16,19-Hexaenoic acid-chim(NtGi2L-Gs-CtGq)/β1/γ2
6.67	Single	8U4P	AMD3100	8U4P-CXCR4-AMD3100-Gi1/β1/γ2
6.67	Single	8U8F	Palmitic Acid	8U8F-GPR3-Palmitic Acid-Gs/β1/γ2
6.67	Single	8UTD	MK1903	8UTD-HCA₂-MK1903-Gi1/β1/γ2
6.67	Single	8WC4	ZH8651	8WC4-TA1-ZH8651-chim(NtGi1-Gs)/β1/γ2
6.67	Single	8WCA	2-Phenylethylamine	8WCA-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/β1/γ2
6.67	Single	8YYW	Alpha-ketoglutarate	8YYW-Oxoglutarate-α-ketoglutarate-α-ketoglutarate-chim(Gi1-CtGq)/β1/γ2
6.67	Single	9C1P	Ca; Tryptophan; '6218; PO4	9C1P-CaS-Ca-Ca; Tryptophan; '6218; PO4
6.67	Single	9C2F	Ca; Ca; Tryptophan; '54149; PO4	9C2F-CaS-Ca-Ca; Ca; Tryptophan; '54149; PO4
6.67	Single	9J5V	CpY	9J5V-LPA₁-CpY-Gi1/β1/γ2
6.67	Consensus	a1_on	Orthosteric Ligand	7LD4-A₁-Adenosine-Gi2/β1/γ2
6.67	Consensus	a1_on_gp	Orthosteric Ligand	7LD4-A₁-Adenosine-Gi2/β1/γ2
6.67	Consensus	class-a_class-b1_cons_on	Orthosteric Ligand	class-a_on class-b1_on
6.67	Consensus	crf1_on	Orthosteric Ligand	6PB0-CRF₁-Urocortin-chim(NtGi1-Gs)/β1/γ2 6P9X-CRF₁-Corticoliberin-Gs/β1/γ2
6.67	Consensus	gip_on	Orthosteric Ligand	7FIN-GIP-Peptide-20; GGL-Gs/β1/γ2 7FIY-GIP-Tirzepatide-Gs/β1/γ2 7DTY-GIP-GIP-Gs/β1/γ2
6.67	Consensus	gip_on_gp	Orthosteric Ligand	7FIN-GIP-Peptide-20; GGL-Gs/β1/γ2 7FIY-GIP-Tirzepatide-Gs/β1/γ2 7DTY-GIP-GIP-Gs/β1/γ2
6.67	Consensus	gnrh1_off	Orthosteric Ligand	7BR3-GnRH₁-Elagolix
6.67	Consensus	rhodopsin_on_gp	Orthosteric Ligand	6OYA-Rhodopsin-All-trans-Retinal-Gt/β1/γ1
6.45	Single	6LPB	PACAP	6LPB-PAC₁-PACAP-Gs/β1/γ1
6.45	Single	7TZF	Amylin	7TZF-CT (AMY3)-Amylin-Gs/β1/γ2; RAMP3
6.45	Single	7VBH	Peptide-20	7VBH-GLP-1-Peptide-20-Gs/β1/γ2
6.45	Single	8F2A	Pramlintide Analogue San385	8F2A-CT (AMY3)-Pramlintide Analogue San385-Gs/β1/γ2; RAMP3
6.45	Single	8FLS	Abaloparatide	8FLS-PTH1-Abaloparatide-Gs/β1/γ2
6.45	Single	8FLU	Long-Acting PTH	8FLU-PTH1-Long-Acting PTH-Gs/β1/γ2
6.45	Single	9AUC	Calcitonin gene-related peptide-1	9AUC-CT (AMY1)-Calcitonin gene-related peptide-1-Gs/β1/γ2; RAMP1
6.25	Single	1F88	11-cis-Retinal	1F88-Rhodopsin-11-cis-Retinal
6.25	Single	2YDO	Adenosine	2YDO-A_2A-Adenosine
6.25	Single	3UZC	4-(3-amino-5-phenyl-1,2,4-triazin-6-yl)-2-chlorophenol	3UZC-A_2A-4-(3-amino-5-phenyl-1,2,4-triazin-6-yl)-2-chlorophenol
6.25	Single	4DKL	Beta-Funaltrexamine	4DKL-μ-β-Funaltrexamine
6.25	Single	4N6H	Naltrindole	4N6H-δ-Naltrindole-Na
6.25	Single	5K2B	ZM-241385	5K2B-A_2A-ZM-241385-Na
6.25	Single	5TE3	Octyl-Beta-D-Glucopyranoside	5TE3-Rhodopsin-Octyl-β-D-Glucopyranoside
6.25	Single	6FKA	PubChem 132473037	6FKA-Rhodopsin-PubChem 132473037
6.25	Single	6ME3	2-Phenylmelatonin	6ME3-MT₁-2-Phenylmelatonin
6.25	Single	6ME4	2-Iodomelatonin	6ME4-MT₁-2-Iodomelatonin
6.25	Single	6PS8	2-Phenylmelatonin	6PS8-MT₁-2-Phenylmelatonin
6.25	Single	6PT0	WIN 55212-2	6PT0-CB₂-WIN 55212-2-Gi1/β1/γ2
6.25	Single	6TPK	Retosiban	6TPK-OT-Retosiban
6.25	Single	6WH4	Methiothepin	6WH4-5-HT_2A-Methiothepin
6.25	Single	6WPW	Glucagon derivative ZP3780	6WPW-Glucagon-Glucagon derivative ZP3780-Gs/β1/γ2
6.25	Single	6ZDV	Chromone 5d	6ZDV-A_2A-Chromone 5d-Na
6.25	Single	7CKW	Fenoldopam	7CKW-D₁-Fenoldopam-Gs/β1/γ2
6.25	Single	7CKZ	Dopamine	7CKZ-D₁-Dopamine-Mevidalen-Gs/β1/γ2
6.25	Single	7F0T	Dopamine	7F0T-D₁-Dopamine-Gs/β1/γ2
6.25	Single	7F1Z	Dopamine	7F1Z-D₁-Dopamine-GDP-Gs/β1/γ2
6.25	Single	7M3G	Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4	7M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
6.25	Single	7V35	Peptide-20	7V35-Glucagon-Peptide-20-Gs/β1/γ2
6.25	Single	7VUG	JNJ-63533054	7VUG-GPR139-JNJ-63533054-Gi1/β1/γ2
6.25	Single	7VVM	PTH	7VVM-PTH1-PTH-Gs/β1/γ2
6.25	Single	7YK6	PubChem 138319674	7YK6-RXFP4-PubChem 138319674-Gi2/β1/γ2
6.25	Single	8GUR	CP55,940	8GUR-CB₂-CP55,940-Gi1/β1/γ2
6.25	Single	8HJ5	PubChem 139030531	8HJ5-MRGPRX1-PubChem 139030531-chim(NtGi1-Gs-CtGq)/β1/γ2
6.25	Single	8IHK	Acifran	8IHK-HCA₃-Acifran
6.25	Single	8JEI	3-nitro-4-(propylamino)benzoic acid	8JEI-HCAR3-3-nitro-4-(propylamino)benzoic acid-Gi1/β1/γ2
6.25	Single	8JIM	MMF	8JIM-HCA₂-MMF-Gi1/β1/γ2
6.25	Single	8JIP	MEDI0382	8JIP-GLP-1-MEDI0382-chim(NtGi1-Gs)/β1/γ2
6.25	Single	8JIR	SAR425899	8JIR-GLP-1-SAR425899-chim(NtGi1-Gs)/β1/γ2
6.25	Single	8JLK	Ulotaront	8JLK-TA1-Ulotaront-chim(NtGi1-Gs)/β1/γ2
6.25	Single	8JLQ	Fenoldopam	8JLQ-TA1-Fenoldopam-Gs/β1/γ2
6.25	Single	8K2W	AMG487	8K2W-CXCR3-AMG487
6.25	Single	8RLN	LUF5834	8RLN-A_2A-LUF5834
6.25	Single	8UHB	RO5256390	8UHB-TA1-RO5256390-Gs/β1/γ2
6.25	Single	8W88	SEP-363856	8W88-TA1-SEP-363856-Gs/β1/γ2
6.25	Single	8WC8	ZH8651	8WC8-TA1-ZH8651-chim(NtGi1-Gs)/β1/γ2
6.25	Single	8X7A	Treprostinil	8X7A-I2-Treprostinil-Gs/β1/γ2
6.25	Single	8Y45	ADL5859	8Y45-δ-ADL5859-Gi2/β1/γ2
6.25	Single	8Y62	C16:0 Ceramide	8Y62-FPR2-ALX-C16:0 Ceramide-Gi1/β1/γ2
6.25	Single	8Y6Y	GLPG0974	8Y6Y-FFA2-GLPG0974
6.25	Single	8YH2	Adenosine	8YH2-A_3A-Adenosine-Gi1/β1/γ2
6.25	Single	8ZPM	AMD070	8ZPM-CXCR4-AMD070
6.25	Single	9ARX	Serotonin	9ARX-5-HT_2A-Serotonin
6.25	Single	9ASB	Ca; Ca; Cyclomethyltryptophan; 9IG; PO4	9ASB-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
6.25	Single	9DQJ	EP-3945	9DQJ-MRGPRD-EP-3945-chim(NtGi1-Gs-CtGq)/β1/γ2
6.25	Single	9EPQ	11,20-Ethanoretinal	9EPQ-Rhodopsin-11,20-Ethanoretinal-chim(Gi1-CtGq)/β1/γ2
6.25	Single	9JKQ	METH	9JKQ-TA1-METH-Gs/β1/γ2
6.25	Single	9JMD	Azithromycin	9JMD-Motilin-Azithromycin-chim(Gs-CtGq)/β1/γ2
6.25	Single	9JR2	PTH	9JR2-PTH1-PTH-chim(NtGi1L-Gs-CtGq)/β1/γ2
6.25	Single	9K1D	Butanoic acid	9K1D-FFA2-Butanoic acid-Gi1/β1/γ2
6.25	Consensus	crf1_on_gp	Orthosteric Ligand	6PB0-CRF₁-Urocortin-chim(NtGi1-Gs)/β1/γ2 6P9X-CRF₁-Corticoliberin-Gs/β1/γ2
6.25	Consensus	crf_on_gp	Orthosteric Ligand	crf2_on_gp crf1_on_gp
6.25	Consensus	cxcr3_off	Orthosteric Ligand	8K2W-CXCR3-AMG487
6.25	Consensus	grh_off	Orthosteric Ligand	gnrh1_off
6.25	Consensus	hca_on	Orthosteric Ligand	hca2_on
6.25	Consensus	opsins_off	Orthosteric Ligand	rhodopsin_off
6.25	Consensus	ot_off	Orthosteric Ligand	6TPK-OT-Retosiban
6.25	Consensus	sensory_off	Orthosteric Ligand	opsins_off
6.25	Consensus	vasop-oxy_off	Orthosteric Ligand	ot_off
6.06	Single	7TYO	Calcitonin	7TYO-CT-Calcitonin-Gs/β1/γ2
6.06	Single	7TYY	Calcitonin-1	7TYY-CT (AMY2)-Calcitonin-1-Gs/β1/γ2; RAMP2
6.06	Single	7Y36	Teriparatide	7Y36-PTH1-Teriparatide-Gs/β1/γ2
6.06	Single	8FLQ	PTH	8FLQ-PTH1-PTH-Gs/β1/γ2
6.06	Single	8JIT	MEDI0382	8JIT-Glucagon-MEDI0382-Gs/β1/γ2
6.06	Single	8JIU	SAR425899	8JIU-Glucagon-SAR425899-Gs/β1/γ2
6.06	Single	9JR3	PTH	9JR3-PTH1-PTH-chim(NtGi1L-Gs-CtGq)/β1/γ2
6.06	Consensus	class-a_class-b1_cons_on_gp	Orthosteric Ligand	class-a_on_gp class-b1_on_gp
6.06	Consensus	glucagon_on	Orthosteric Ligand	glp_on gluc_on secretin_on gip_on
5.88	Single	2Y01	Dobutamine	2Y01-β₁-Dobutamine
5.88	Single	4EJ4	Naltrindole	4EJ4-δ-Naltrindole
5.88	Single	4J4Q	Octyl Beta-D-Glucopyranoside	4J4Q-Rhodopsin-Octyl β-D-Glucopyranoside-Gt(CT)
5.88	Single	4X1H	Nonyl-Beta-D-Glucopyranoside	4X1H-Rhodopsin-Nonyl-β-D-Glucopyranoside-Gt(CT)
5.88	Single	5NDD	AZ8838; Na	5NDD-PAR2-AZ8838; Na
5.88	Single	5ZKP	Foropafant (SR27417)	5ZKP-PAF-Foropafant (SR27417)
5.88	Single	6E3Y	Calcitonin gene-related peptide-1	6E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/β1/γ2; RAMP1
5.88	Single	6FKD	PubChem 137349183	6FKD-Rhodopsin-PubChem 137349183
5.88	Single	6GPS	MK0812	6GPS-CCR2-MK0812
5.88	Single	6IIV	Daltroban	6IIV-TXA2-Daltroban
5.88	Single	6WHA	DB13948	6WHA-5-HT_2A-DB13948-chim(NtGi2L-Gs-CtGq)/β1/γ2
5.88	Single	7BU7	BI167107	7BU7-β₁-BI167107
5.88	Single	7CRH	SKF83959	7CRH-D₁-SKF83959-Gs/β1/γ2
5.88	Single	7DB6	Ramelteon	7DB6-MT₁-Ramelteon-Gi1/β1/γ2
5.88	Single	7JOZ	VFP	7JOZ-D₁-VFP-Gs/β1/γ2
5.88	Single	7JVQ	Apomorphine	7JVQ-D₁-Apomorphine-Gs/β1/γ2
5.88	Single	7LCI	Danuglipron	7LCI-GLP-1-Danuglipron-Gs/β1/γ2
5.88	Single	7LJC	SKF-81297	7LJC-D₁-SKF-81297-Mevidalen-Gs/β1/γ2
5.88	Single	7PP1	Selatogrel	7PP1-P2Y₁₂-Selatogrel
5.88	Single	7T2G	Mitragynine Pseudoindoxyl	7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2
5.88	Single	7V3Z	CP55940	7V3Z-CB₁-CP55940
5.88	Single	7VGZ	Remalteon	7VGZ-MT₁-Remalteon-Gi1/β1/γ2
5.88	Single	7VIE	S1P	7VIE-S1P₁-S1P-Gi1/β1/γ2
5.88	Single	7VIF	S-FTY720-P	7VIF-S1P₁-S-FTY720-P-Gi1/β1/γ2
5.88	Single	7VKT	LTB4	7VKT-BLT₁-LTB4-Gi1/β1/γ2
5.88	Single	7WC8	Lumateperone	7WC8-5-HT_2A-Lumateperone
5.88	Single	7WQ3	Galanin	7WQ3-GAL₁-Galanin-Gi1/β1/γ2
5.88	Single	7X2C	Fenoldopam	7X2C-D₁-Fenoldopam-Fenoldopam-Gs/β1/γ2
5.88	Single	7XTC	5-CT	7XTC-5-HT₇-5-CT-Gs/β1/γ2
5.88	Single	8CIC	Etrumadenant	8CIC-A_2A-Etrumadenant-Na
5.88	Single	8GCM	L902688	8GCM-EP₄-L902688-Gi1/β1/γ2
5.88	Single	8J6P	Niacin	8J6P-HCA₂-Niacin-Compound 9n-Gi1/β1/γ2
5.88	Single	8JD0	NAM563	8JD0-mGlu2; mGlu3-Glutamate-NAM563
5.88	Single	8JLZ	ST1936	8JLZ-5-HT₆-ST1936-Gs/β1/γ2
5.88	Single	8KFY	ZK-756326	8KFY-CCR8-ZK-756326-Gi1/β1/γ2
5.88	Single	8T1W	CVN424	8T1W-GPR6-CVN424
5.88	Single	8W87	METH	8W87-TA1-METH-chim(NtGi1L-Gs)/β1/γ2
5.88	Single	8W8A	RO5256390	8W8A-TA1-RO5256390-chim(NtGi1L-Gs)/β1/γ2
5.88	Single	8XBG	S3E-LysoPS	8XBG-GPR34-S3E-LysoPS
5.88	Single	8YH5	Riboprine	8YH5-A_3A-Riboprine-Gi1/β1/γ2
5.88	Single	8ZQE	GPR15L(C11)	8ZQE-GPR15-GPR15L(C11)-Gi1/β1/γ1
5.88	Single	8ZSS	RO5263397	8ZSS-TA1-RO5263397-chim(NtGi1-Gs)/β1/γ2
5.88	Single	9AVG	Ca; Ca; Cyclomethyltryptophan; 9IG; PO4	9AVG-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs)/β1/γ2
5.88	Single	9CHX	S-Carazolol	9CHX-β₂-S-Carazolol
5.88	Single	9D61	JDTic	9D61-κ-JDTic-Gi1/β1/γ2
5.88	Single	9EPP	11,20-Ethanoretinal	9EPP-Rhodopsin-11,20-Ethanoretinal-chim(Gi1-CtGq)/β1/γ2
5.88	Single	9IVG	GLP-1 (Truncated)	9IVG-GLP-1-GLP-1 (Truncated)-chim(NtGi1-Gs)/β1/γ2
5.88	Single	9IYA	ONO-9710531	9IYA-GPR55-ONO-9710531
5.88	Single	9JGK	Balovaptan	9JGK-5-HT_2B-Balovaptan
5.88	Consensus	5ht6_on	Orthosteric Ligand	7XTB-5-HT₆-Serotonin-Gs/β1/γ2 8JLZ-5-HT₆-ST1936-Gs/β1/γ2
5.88	Consensus	5ht6_on_gp	Orthosteric Ligand	7XTB-5-HT₆-Serotonin-Gs/β1/γ2 8JLZ-5-HT₆-ST1936-Gs/β1/γ2
5.88	Consensus	5ht7_on	Orthosteric Ligand	7XTC-5-HT₇-5-CT-Gs/β1/γ2
5.88	Consensus	5ht7_on_gp	Orthosteric Ligand	7XTC-5-HT₇-5-CT-Gs/β1/γ2
5.88	Consensus	alicarboxylic_on_gp	Orthosteric Ligand	succinate_on_gp hca_on_gp
5.88	Consensus	blt1_on	Orthosteric Ligand	7VKT-BLT₁-LTB4-Gi1/β1/γ2
5.88	Consensus	blt1_on_gp	Orthosteric Ligand	7VKT-BLT₁-LTB4-Gi1/β1/γ2
5.88	Consensus	blt_on	Orthosteric Ligand	blt1_on
5.88	Consensus	blt_on_gp	Orthosteric Ligand	blt1_on_gp
5.88	Consensus	ccr2_off	Orthosteric Ligand	6GPS-CCR2-MK0812
5.88	Consensus	dop_off	Orthosteric Ligand	4EJ4-δ-Naltrindole
5.88	Consensus	gal1_on	Orthosteric Ligand	7WQ3-GAL₁-Galanin-Gi1/β1/γ2
5.88	Consensus	gal1_on_gp	Orthosteric Ligand	7WQ3-GAL₁-Galanin-Gi1/β1/γ2
5.88	Consensus	gi_alicarboxylic	Orthosteric Ligand	gi_hca gi_succinate
5.88	Consensus	gi_galanin	Orthosteric Ligand	7WQ3-GAL₁-Galanin-Gi1/β1/γ2
5.88	Consensus	gi_hca	Orthosteric Ligand	8J6R-HCA₂-MK6892-Gi1/β1/γ2 8JIM-HCA₂-MMF-Gi1/β1/γ2 8IHI-HCA₂-Acifran-Gi1/β1/γ2 8IHH-HCA₂-LUF6283-Gi1/β1/γ2 8I7V-HCA₂-Acipimox-Gi1/β1/γ2 8I7W-HCA₂-GSK256073-Gi1/β1/γ2
5.88	Consensus	gi_leukotriene	Orthosteric Ligand	7VKT-BLT₁-LTB4-Gi1/β1/γ2
5.88	Consensus	gluc_on	Orthosteric Ligand	6LMK-Glucagon-Glucagon-Gs/β1/γ2 8JIT-Glucagon-MEDI0382-Gs/β1/γ2 7V35-Glucagon-Peptide-20-Gs/β1/γ2
5.88	Consensus	glucagon_on_gp	Orthosteric Ligand	glp_on_gp gluc_on_gp secretin_on_gp gip_on_gp
5.88	Consensus	gs_trace-amine	Orthosteric Ligand	8W88-TA1-SEP-363856-Gs/β1/γ2 8JLJ-TA1-T1AM-chim(NtGi1-Gs)/β1/γ2 8JLO-TA1-Ulotaront-Gs/β1/γ2 8WC4-TA1-ZH8651-chim(NtGi1-Gs)/β1/γ2 8WC7-TA1-ZH8667-chim(NtGi1-Gs)/β1/γ2 8JLR-TA1-A77636-chim(NtGi1-Gs)/β1/γ2 8JSO-TA1-AMPH-chim(NtGi1-Gs)/β1/γ2 8W87-TA1-METH-chim(NtGi1L-Gs)/β1/γ2 8W89-TA1-PEA-chim(NtGi1L-Gs)/β1/γ2 8JLP-TA1-Ralmitaront-Gs/β1/γ2 8W8A-TA1-RO5256390-chim(NtGi1L-Gs)/β1/γ2
5.88	Consensus	hca2_on	Orthosteric Ligand	8J6R-HCA₂-MK6892-Gi1/β1/γ2 8JIM-HCA₂-MMF-Gi1/β1/γ2 8I7V-HCA₂-Acipimox-Gi1/β1/γ2 8I7W-HCA₂-GSK256073-Gi1/β1/γ2 8IHH-HCA₂-LUF6283-Gi1/β1/γ2 8IHI-HCA₂-Acifran-Gi1/β1/γ2
5.88	Consensus	hca2_on_gp	Orthosteric Ligand	8J6R-HCA₂-MK6892-Gi1/β1/γ2 8IHI-HCA₂-Acifran-Gi1/β1/γ2 8IHH-HCA₂-LUF6283-Gi1/β1/γ2 8I7V-HCA₂-Acipimox-Gi1/β1/γ2 8JIM-HCA₂-MMF-Gi1/β1/γ2 8I7W-HCA₂-GSK256073-Gi1/β1/γ2
5.88	Consensus	hca_on_gp	Orthosteric Ligand	hca2_on_gp
5.88	Consensus	leukotriene_on	Orthosteric Ligand	blt_on
5.88	Consensus	leukotriene_on_gp	Orthosteric Ligand	blt_on_gp
5.88	Consensus	pth_on	Orthosteric Ligand	pth1_on pth2_on
5.71	Consensus	gluc_on_gp	Orthosteric Ligand	6LMK-Glucagon-Glucagon-Gs/β1/γ2 8JIT-Glucagon-MEDI0382-Gs/β1/γ2 7V35-Glucagon-Peptide-20-Gs/β1/γ2
5.56	Single	2Y00	Dobutamine	2Y00-β₁-Dobutamine
5.56	Single	4NTJ	AZD1283	4NTJ-P2Y₁₂-AZD1283
5.56	Single	5C1M	BU72	5C1M-μ-BU72
5.56	Single	5T1A	BMS-681	5T1A-CCR2-BMS-681-PubChem 12093170
5.56	Single	5X7D	S-Carazolol	5X7D-β₂-S-Carazolol-Cmpd-15
5.56	Single	5ZBQ	UR-MK-299	5ZBQ-Y₁-UR-MK-299
5.56	Single	5ZK3	3-quinuclidinyl-benzilate	5ZK3-M₂-3-quinuclidinyl-benzilate
5.56	Single	6E67	BI167107	6E67-β₂-BI167107-Gs(CT)
5.56	Single	6GPX	MK0812	6GPX-CCR2-MK0812
5.56	Single	6HLP	Netupitant	6HLP-NK₁-Netupitant
5.56	Single	6KPC	PubChem 145915889	6KPC-CB₂-PubChem 145915889
5.56	Single	6ME6	2-Phenylmelatonin	6ME6-MT₂-2-Phenylmelatonin
5.56	Single	6ME7	2-Phenylmelatonin	6ME7-MT₂-2-Phenylmelatonin
5.56	Single	6ME8	2-Phenylmelatonin	6ME8-MT₂-2-Phenylmelatonin
5.56	Single	6RZ4	Pranlukast	6RZ4-CysLT₁-Pranlukast-Na
5.56	Single	6TO7	Suvorexant	6TO7-OX₁-Suvorexant-Na
5.56	Single	6Z4Q	SR142948A	6Z4Q-NTS₁-SR142948A
5.56	Single	6Z4S	SR48692	6Z4S-NTS₁-SR48692
5.56	Single	7BB7	AVP	7BB7-V₂-AVP-Gs/β1/γ2
5.56	Single	7C4S	S1P	7C4S-S1P₃-S1P
5.56	Single	7C61	Ergotamine	7C61-5-HT_1B-Ergotamine
5.56	Single	7CKX	A77636	7CKX-D₁-A77636-Gs/β1/γ2
5.56	Single	7E9G	JNJ-40411813	7E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/β1/γ2
5.56	Single	7F16	TIP39	7F16-PTH2-TIP39-Gs/β1/γ2
5.56	Single	7M3G	Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4	7M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
5.56	Single	7SBF	PZM21	7SBF-μ-PZM21-Gi1/β1/γ2
5.56	Single	7SIN	NPS-2143	7SIN-CaS-NPS-2143
5.56	Single	7SIN	NPS-2143	7SIN-CaS-NPS-2143
5.56	Single	7VUH	JNJ-63533054	7VUH-GPR139-JNJ-63533054-chim(Gs-CtGq)/β1/γ2
5.56	Single	7W41	PD176252	7W41-BB₂-PD176252
5.56	Single	7WC6	LSD	7WC6-5-HT_2A-LSD
5.56	Single	8C9W	Etrumadenant	8C9W-A_2A-Etrumadenant
5.56	Single	8GDC	PGE2	8GDC-EP₃-PGE2-Gi1/β1/γ2
5.56	Single	8HNL	PS372424	8HNL-CXCR3-PS372424-Gi1/β1/γ2
5.56	Single	8J18	(3R)-3-Hydroxydodecanoic acid	8J18-GPR84-(3R)-3-Hydroxydodecanoic acid-Gi1/β1/γ2
5.56	Single	8JGG	BAM8-22	8JGG-MRGPRX1-BAM8-22-Gi1/β1/γ2
5.56	Single	8JXS	PF-6142	8JXS-D₁-PF-6142
5.56	Single	8K8J	Fenofibrate	8K8J-CB₁-Fenofibrate-chim(Gs-CtGq)/β1/γ2
5.56	Single	8S4D	CMF-019	8S4D-Apelin-CMF-019
5.56	Single	8SZG	Ca; Ca; Tryptophan; Cinacalcet; PO4; Spermine	8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; Spermine-chim(NtGi1-Gq)/β1/γ2
5.56	Single	8XYK	VUF10661	8XYK-CXCR3-VUF10661-Go/β1/γ2
5.56	Single	8YH0	NECA	8YH0-A_3A-NECA-Gi1/β1/γ2
5.56	Single	8ZVZ	BW245C	8ZVZ-DP₁-BW245C-Gs/β1/γ2
5.56	Single	9ARY	Serotonin	9ARY-5-HT_2A-Serotonin-chim(NtGi1-Gs-CtGq)/β1/γ2
5.56	Single	9AVL	Ca; Ca; Cyclomethyltryptophan; 9IG; PO4	9AVL-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi3/β2/γ2
5.56	Single	9AXF	Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4	9AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
5.56	Single	9AYF	Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4	9AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/β1/γ2
5.56	Single	9DQH	EP-2825	9DQH-MRGPRD-EP-2825-chim(NtGi1-Gs-CtGq)/β1/γ2
5.56	Single	9HAP	Tolvaptan	9HAP-V₂-Tolvaptan
5.56	Single	9I52	A1IZU	9I52-D₁-A1IZU-Gs/β1/γ2
5.56	Single	9IYB	Prostaglandin	9IYB-DP₂-Prostaglandin-A1D5Q-Gi1/β1/γ2
5.56	Consensus	adgrg2_on	Orthosteric Ligand	7WUI-ADGRG2-IP15-chim(NtGi1-Gs)/β1/γ2 7WUQ-ADGRG2-Gs/β1/γ2 7XKF-ADGRG2-β-Hydroxyandrosterone-Gs/β1/γ2
5.56	Consensus	adgrg2_on_gp	Orthosteric Ligand	7WUI-ADGRG2-IP15-chim(NtGi1-Gs)/β1/γ2 7WUQ-ADGRG2-Gs/β1/γ2 7XKF-ADGRG2-β-Hydroxyandrosterone-Gs/β1/γ2
5.56	Consensus	bb2_off	Orthosteric Ligand	7W41-BB₂-PD176252
5.56	Consensus	blt1_off	Orthosteric Ligand	5X33-BLT₁-BIIL260 7K15-BLT₁-MKD046-Na
5.56	Consensus	blt_off	Orthosteric Ligand	blt1_off
5.56	Consensus	bombesin_off	Orthosteric Ligand	bb2_off
5.56	Consensus	cb2_on	Orthosteric Ligand	8GUR-CB₂-CP55,940-Gi1/β1/γ2 8GUS-CB₂-HU-308-Gi1/β1/γ2 8GUT-CB₂-LEI-102-Gi1/β1/γ2 6KPF-CB₂-PubChem 145915889-Gi1/β1/γ2 6PT0-CB₂-WIN 55212-2-Gi1/β1/γ2 8GUQ-CB₂-Olorinab-Gi1/β1/γ2
5.56	Consensus	cb2_on_gp	Orthosteric Ligand	8GUR-CB₂-CP55,940-Gi1/β1/γ2 8GUS-CB₂-HU-308-Gi1/β1/γ2 8GUT-CB₂-LEI-102-Gi1/β1/γ2 6KPF-CB₂-PubChem 145915889-Gi1/β1/γ2 6PT0-CB₂-WIN 55212-2-Gi1/β1/γ2 8GUQ-CB₂-Olorinab-Gi1/β1/γ2
5.56	Consensus	class-b1_on	Orthosteric Ligand	glucagon_on vip-pacap_on pth_on crf_on calcitonin_on
5.56	Consensus	cyslt_off	Orthosteric Ligand	cyslt2_off cyslt1_off
5.56	Consensus	d1_on	Orthosteric Ligand	7F0T-D₁-Dopamine-Gs/β1/γ2 7CKY-D₁-PW0464-Gs/β1/γ2 8IRR-D₁-Rotigotine-Gs/β1/γ2 7JV5-D₁-SKF81297-Gs/β1/γ2 7JVP-D₁-SKF83959-Gs/β1/γ2 7X2D-D₁-Tavapadon-Gs/β1/γ2 7CKX-D₁-A77636-Gs/β1/γ2 7JVQ-D₁-Apomorphine-Gs/β1/γ2 7CKW-D₁-Fenoldopam-Gs/β1/γ2
5.56	Consensus	gs_amine	Orthosteric Ligand	gs_5ht gs_adrenergic gs_dopamine gs_histamine gs_trace-amine
5.56	Consensus	ta1_on	Orthosteric Ligand	8W87-TA1-METH-chim(NtGi1L-Gs)/β1/γ2 8W89-TA1-PEA-chim(NtGi1L-Gs)/β1/γ2 8JLP-TA1-Ralmitaront-Gs/β1/γ2 8W8A-TA1-RO5256390-chim(NtGi1L-Gs)/β1/γ2 8W88-TA1-SEP-363856-Gs/β1/γ2 8JLO-TA1-Ulotaront-Gs/β1/γ2 8JLR-TA1-A77636-chim(NtGi1-Gs)/β1/γ2 8JSO-TA1-AMPH-chim(NtGi1-Gs)/β1/γ2 8ZSP-TA1-LSD-chim(NtGi1L-Gs-CtGq)/β1/γ2
5.56	Consensus	trace-amine_on	Orthosteric Ligand	ta1_on
5.41	Single	8F0J	Pramlintide Analogue San45	8F0J-CT-Pramlintide Analogue San45-Gs/β1/γ2
5.26	Single	2YDV	NECA	2YDV-A_2A-NECA
5.26	Single	3P0G	BI167107	3P0G-β₂-BI167107
5.26	Single	3PDS	Hydroxybenzylisoproterenol	3PDS-β₂-Hydroxybenzylisoproterenol
5.26	Single	3UON	3-quinuclidinyl-benzilate	3UON-M₂-3-quinuclidinyl-benzilate
5.26	Single	4IAQ	Dihydroergotamine	4IAQ-5-HT_1B-Dihydroergotamine
5.26	Single	4LDL	Hydroxybenzylisoproterenol	4LDL-β₂-Hydroxybenzylisoproterenol
5.26	Single	4UHR	CGS21680	4UHR-A_2A-CGS21680
5.26	Single	5A8E	7-Methylcyanopindolol	5A8E-β₁-7-Methylcyanopindolol-Na
5.26	Single	5G53	NECA	5G53-A_2A-NECA-Gs
5.26	Single	5V54	Methiothepin	5V54-5-HT_1B-Methiothepin
5.26	Single	5XR8	AM841	5XR8-CB₁-AM841
5.26	Single	5XRA	AM11542	5XRA-CB₁-AM11542
5.26	Single	5ZBH	BMS-193885	5ZBH-Y₁-BMS-193885
5.26	Single	5ZHP	PubChem 134828589	5ZHP-M₃-PubChem 134828589
5.26	Single	6E59	L-760735	6E59-NK₁-L-760735
5.26	Single	6J20	Aprepitant	6J20-NK₁-Aprepitant
5.26	Single	6N48	BI167107	6N48-β₂-BI167107-PubChem 138454256
5.26	Single	6O3C	Cholesterol	6O3C-SMO-SAG21k-Cholesterol
5.26	Single	6RZ5	Zafirlukast	6RZ5-CysLT₁-Zafirlukast-Na
5.26	Single	7CKY	PW0464	7CKY-D₁-PW0464-Gs/β1/γ2
5.26	Single	7EW1	Siponimod	7EW1-S1P₅-Siponimod-Gi1/β1/γ2
5.26	Single	7EW3	S1P	7EW3-S1P₃-S1P-Gi1/β1/γ2
5.26	Single	7EW7	SEW2871	7EW7-S1P₁-SEW2871-Gi1/β1/γ2
5.26	Single	7FEE	CP55940	7FEE-CB₁-CP55940-ZCZ011
5.26	Single	7JV5	SKF81297	7JV5-D₁-SKF81297-Gs/β1/γ2
5.26	Single	7JVP	SKF83959	7JVP-D₁-SKF83959-Gs/β1/γ2
5.26	Single	7M8W	15r-Methyl-Prostaglandin D2	7M8W-DP₂-15r-Methyl-Prostaglandin D2-Na
5.26	Single	7R0C	AVP	7R0C-V₂-AVP-Arrestin2
5.26	Single	7WV9	CP55940	7WV9-CB₁-CP55940-ZCZ011-Gi2/β1/γ2
5.26	Single	7WVX	Humanin	7WVX-FPR2-ALX-Humanin-Gi2/β1/γ2
5.26	Single	7XAV	Lanreotide	7XAV-SST2-Lanreotide-Gi1/β1/γ2
5.26	Single	7XBD	Galanin	7XBD-GAL₂-Galanin-chim(NtGi2L-Gs-CtGq)/β1/γ2
5.26	Single	7XJL	Spexin	7XJL-GAL₂-Spexin-chim(NtGi2L-Gs-CtGq)/β1/γ2
5.26	Single	7XOW	Gastrin	7XOW-CCK_B-Gastrin-chim(NtGi1-Gq)/β1/γ2
5.26	Single	7XWO	Neurokinin-A	7XWO-NK₂-Neurokinin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
5.26	Single	7XY7	NECA	7XY7-A_2B-NECA-chim(NtGi1-Gs)/β1/γ2
5.26	Single	7Y67	C089 peptide	7Y67-C5a₁-C089 peptide-Gi1/β1/γ2
5.26	Single	8E0G	BU72	8E0G-μ-BU72
5.26	Single	8F2B	Pramlintide Analogue San45	8F2B-CT (AMY3)-Pramlintide Analogue San45-Gs/β1/γ2; RAMP3
5.26	Single	8GDB	PGE2	8GDB-EP₄-PGE2-Gs/β1/γ2
5.26	Single	8GUS	HU-308	8GUS-CB₂-HU-308-Gi1/β1/γ2
5.26	Single	8HDO	BAY 60-6583	8HDO-A_2B-BAY 60-6583-Gs/β1/γ2
5.26	Single	8HPT	C5a anaphylatoxin C-terminal peptide	8HPT-C5a₁-C5a anaphylatoxin C-terminal peptide-Go/β1/γ2
5.26	Single	8IRR	Rotigotine	8IRR-D₁-Rotigotine-Gs/β1/γ2
5.26	Single	8IUK	PGF2-alpha	8IUK-FP-alpha-PGF2-α-chim(NtGi1-Gs-CtGq)/β1/γ2
5.26	Single	8JD5	JNJ-40411813; ADX88178	8JD5-mGlu2; mGlu4-Glutamate-JNJ-40411813; ADX88178-Gi1/β1/γ2
5.26	Single	8JLP	Ralmitaront	8JLP-TA1-Ralmitaront-Gs/β1/γ2
5.26	Single	8JSR	Anamorelin	8JSR-Ghrelin-Anamorelin-chim(NtGi1-Gs-CtGq)/β1/γ2
5.26	Single	8JXV	Clozapine	8JXV-H₄-Clozapine-Gi1/β1/γ2
5.26	Single	8JXW	VUF6884	8JXW-H₄-VUF6884-Gi1/β1/γ2
5.26	Single	8JXX	Clobenpropit	8JXX-H₄-Clobenpropit-Gi1/β1/γ2
5.26	Single	8UGW	PubChem 3086599	8UGW-A_2A-PubChem 3086599
5.26	Single	8VVF	JDTic	8VVF-κ-JDTic-Gi1/β1/γ2
5.26	Single	8X79	MRE-269	8X79-I2-MRE-269-Gs/β1/γ2
5.26	Single	8XIP	Pasireotide	8XIP-SST1-Pasireotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
5.26	Single	8XJM	Latanoprost	8XJM-FP-alpha-Latanoprost-chim(NtGi2-Gs-CtGq)/β1/γ2
5.26	Single	8XQT	Cholesterol	8XQT-TAS2R14-Cholesterol-Gi1/β1/γ1
5.26	Single	8Y73	Peptide	8Y73-μ-Peptide-MPAM-15-Gi1/β1/γ2
5.26	Single	8ZR5	Firuglipel	8ZR5-GPR119-Firuglipel-Gs/β1/γ2
5.26	Single	8ZWF	JR14a	8ZWF-C3a_B-JR14a
5.26	Single	9AYF	Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4	9AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/β1/γ2
5.26	Single	9BJK	Naloxone	9BJK-μ-Naloxone-NAM
5.26	Single	9CLW	TUG-1375	9CLW-FFA2-TUG-1375-4-CMTB-chim(NtGi1L-Gs-CtGq)/β1/γ2
5.26	Single	9I54	A1IZV	9I54-D₁-A1IZV-Gs/β1/γ2
5.26	Single	9IJD	Carazolol	9IJD-β₃-Carazolol-chim(NtGi1-Gs)/β1/γ2
5.26	Single	9IK9	SST analogue	9IK9-SST1-SST analogue-Gi1/β1/γ2
5.26	Single	9UY3	Anamorelin	9UY3-Ghrelin-Anamorelin-chim(NtGi1-Gs-CtGq)/β1/γ2
5.26	Consensus	5ht1_off	Orthosteric Ligand	5ht1b_off
5.26	Consensus	5ht1b_off	Orthosteric Ligand	5V54-5-HT_1B-Methiothepin
5.26	Consensus	cyslt1_off	Orthosteric Ligand	6RZ5-CysLT₁-Zafirlukast-Na 6RZ4-CysLT₁-Pranlukast-Na
5.26	Consensus	d1_on_gp	Orthosteric Ligand	7F0T-D₁-Dopamine-Gs/β1/γ2 7CKY-D₁-PW0464-Gs/β1/γ2 8IRR-D₁-Rotigotine-Gs/β1/γ2 7JV5-D₁-SKF81297-Gs/β1/γ2 7JVP-D₁-SKF83959-Gs/β1/γ2 7X2D-D₁-Tavapadon-Gs/β1/γ2 7CKX-D₁-A77636-Gs/β1/γ2 7JVQ-D₁-Apomorphine-Gs/β1/γ2 7CKW-D₁-Fenoldopam-Gs/β1/γ2
5.26	Consensus	gi_cannabinoid	Orthosteric Ligand	8GUR-CB₂-CP55,940-Gi1/β1/γ2 8GUS-CB₂-HU-308-Gi1/β1/γ2 8GUT-CB₂-LEI-102-Gi1/β1/γ2 8GUQ-CB₂-Olorinab-Gi1/β1/γ2 6KPF-CB₂-PubChem 145915889-Gi1/β1/γ2 6PT0-CB₂-WIN 55212-2-Gi1/β1/γ2 6KPG-CB₁-AM841-Gi1/β1/γ2
5.26	Consensus	gs_adrenergic	Orthosteric Ligand	7DHI-β₂-Salbutamol-Gs/β1/γ2 7XJI-β₃-Solabegron-Gs/β1/γ2 7JJO-β₁-Isoprenaline-Gs/β1/γ2 6NI3-β₂-BI167107-Gs/β1/γ2 8DCR-β₁-Dobutamine-Gs/β1/γ2 7XJH-β₃-Isoproterenol-Gs/β1/γ2 7DH5-β₃-Mirabegron-Gs/β1/γ2
5.26	Consensus	gs_dopamine	Orthosteric Ligand	7F0T-D₁-Dopamine-Gs/β1/γ2 7CKW-D₁-Fenoldopam-Gs/β1/γ2 7CKY-D₁-PW0464-Gs/β1/γ2 8IRV-D₅-Rotigotine-chim(NtGi1-Gs)/β1/γ2 8IRR-D₁-Rotigotine-Gs/β1/γ2 7JV5-D₁-SKF81297-Gs/β1/γ2 7JVP-D₁-SKF83959-Gs/β1/γ2 7X2D-D₁-Tavapadon-Gs/β1/γ2 7CKX-D₁-A77636-Gs/β1/γ2 7JVQ-D₁-Apomorphine-Gs/β1/γ2
5.26	Consensus	nk2_on_gp	Orthosteric Ligand	7XWO-NK₂-Neurokinin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
5.26	Consensus	npy1_off	Orthosteric Ligand	5ZBH-Y₁-BMS-193885 5ZBQ-Y₁-UR-MK-299
5.26	Consensus	npy_off	Orthosteric Ligand	npy1_off npy2_off
5.26	Consensus	pth_on_gp	Orthosteric Ligand	pth1_on_gp pth2_on_gp
5.26	Consensus	s1p5_on	Orthosteric Ligand	7EW1-S1P₅-Siponimod-Gi1/β1/γ2
5.26	Consensus	s1p5_on_gp	Orthosteric Ligand	7EW1-S1P₅-Siponimod-Gi1/β1/γ2
5.26	Consensus	ta1_on_gp	Orthosteric Ligand	8W87-TA1-METH-chim(NtGi1L-Gs)/β1/γ2 8W89-TA1-PEA-chim(NtGi1L-Gs)/β1/γ2 8JLP-TA1-Ralmitaront-Gs/β1/γ2 8W8A-TA1-RO5256390-chim(NtGi1L-Gs)/β1/γ2 8W88-TA1-SEP-363856-Gs/β1/γ2 8JLO-TA1-Ulotaront-Gs/β1/γ2 8JLR-TA1-A77636-chim(NtGi1-Gs)/β1/γ2 8JSO-TA1-AMPH-chim(NtGi1-Gs)/β1/γ2 8ZSP-TA1-LSD-chim(NtGi1L-Gs-CtGq)/β1/γ2
5.26	Consensus	tachykinin_off	Orthosteric Ligand	nk1_off
5.26	Consensus	trace-amine_on_gp	Orthosteric Ligand	ta1_on_gp
5.00	Single	3VW7	Vorapaxar; Na	3VW7-PAR1-Vorapaxar; Na
5.00	Single	4LDE	BI167107	4LDE-β₂-BI167107
5.00	Single	4OR2	FITM	4OR2-mGlu1; mGlu1-FITM
5.00	Single	4RWA	DIPP-NH2	4RWA-δ-DIPP-NH2
5.00	Single	5F8U	Cyanopindolol	5F8U-β₁-Cyanopindolol
5.00	Single	5X33	BIIL260	5X33-BLT₁-BIIL260
5.00	Single	6A93	Risperidone	6A93-5-HT_2A-Risperidone
5.00	Single	6C1R	PMX53	6C1R-C5a₁-PMX53-Avacopan; Na
5.00	Single	6CM4	Risperidone	6CM4-D₂-Risperidone
5.00	Single	6H7N	S-Xamoterol	6H7N-β₁-S-Xamoterol
5.00	Single	6IIU	Ramatroban	6IIU-TXA2-Ramatroban
5.00	Single	6KQI	CP55940	6KQI-CB₁-CP55940-Org27569
5.00	Single	6MXT	Salmeterol	6MXT-β₂-Salmeterol
5.00	Single	6XBL	Cholesterol	6XBL-SMO-SAG-Cholesterol-Gi1/β1/γ2
5.00	Single	6XOX	Orforglipron	6XOX-GLP-1-Orforglipron-chim(NtGi1-Gs)/β1/γ2
5.00	Single	7BZ2	Arformoterol	7BZ2-β₂-Arformoterol-Gs/β1/γ2
5.00	Single	7EO4	BAF312	7EO4-S1P₁-BAF312-Gi1/β1/γ2
5.00	Single	7K15	MKD046	7K15-BLT₁-MKD046-Na
5.00	Single	7L1U	Orexin	7L1U-OX₂-Orexin-chim(NtGi1-Gs-CtGq)/β1/γ2
5.00	Single	7WQ4	Galanin	7WQ4-GAL₂-Galanin-chim(NtGi1-Gs-CtGq)/β1/γ2
5.00	Single	7XJK	Galanin	7XJK-GAL₂-Galanin-chim(NtGi2L-Gs-CtGq)/β1/γ2
5.00	Single	7XMT	J-2156	7XMT-SST4-J-2156-Gi1/β1/γ2
5.00	Single	7XZ5	Lysophosphatidylcholine	7XZ5-GPR119-Lysophosphatidylcholine-Gs/β1/γ2
5.00	Single	7Y66	BM213	7Y66-C5a₁-BM213-Gi1/β1/γ2
5.00	Single	7YIT	Nalfurafine	7YIT-κ-Nalfurafine
5.00	Single	8G05	6-OAU	8G05-GPR84-6-OAU-Gi1/β1/γ2
5.00	Single	8H0Q	Gastrin Releasing Peptide	8H0Q-BB₂-Gastrin Releasing Peptide-chim(NtGi1-Gs-CtGq)/β1/γ2
5.00	Single	8I9A	EP54	8I9A-C3a_B-EP54-chim(NtGi1-Gs-CtGq)/β1/γ2
5.00	Single	8IA8	E7 peptide	8IA8-C3a_B-E7 peptide-Gi1/β1/γ2
5.00	Single	8IQ6	Latanoprost	8IQ6-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/β1/γ2
5.00	Single	8JD3	JNJ-40411813	8JD3-mGlu2; mGlu3-Glutamate-JNJ-40411813-Gi1/β1/γ2
5.00	Single	8JJ8	Formoterol	8JJ8-β₂-Formoterol
5.00	Single	8JJL	Olodaterol	8JJL-β₂-Olodaterol
5.00	Single	8JJP	Chemerin	8JJP-CML2-Chemerin-Gi1/β1/γ2
5.00	Single	8W1V	PubChem 171716265	8W1V-β₂-PubChem 171716265
5.00	Single	8XJN	Cloprosetnol	8XJN-TXA2-Cloprosetnol-chim(NtGi1-Gs-CtGq)/β1/γ2
5.00	Single	8XQN	Cholesterol	8XQN-TAS2R14-Cholesterol-Aristolochic acid A-Gi1/β1/γ1
5.00	Single	8XQS	Cholesterol	8XQS-TAS2R14-Cholesterol-Flufenamic acid-Gi1/β1/γ1
5.00	Single	8XYI	VUF10661	8XYI-CXCR3-VUF10661
5.00	Single	9BJK	NAM	9BJK-μ-Naloxone-NAM
5.00	Single	9CM3	TUG-1375	9CM3-FFA2-TUG-1375-Compound 187-chim(NtGi1L-Gs-CtGq)/β1/γ2
5.00	Single	9GGG	I-BOP	9GGG-TXA2-I-BOP-chim(NtGi2L-Gs-CtGq)/β1/γ2
5.00	Single	9L3W	Retinoic acid receptor responder protein 2	9L3W-CML1-Retinoic acid receptor responder protein 2-Gi1/β1/γ2
5.00	Single	9M4Q	Doxazosin	9M4Q-Alpha1A-Doxazosin
5.00	Consensus	beta_on	Orthosteric Ligand	beta1_on beta2_on beta3_on
5.00	Consensus	beta_on_gp	Orthosteric Ligand	beta1_on_gp beta2_on_gp beta3_on_gp
5.00	Consensus	c3a_on	Orthosteric Ligand	8HK2-C3a_B-C3a anaphylatoxin-Gi1/β1/γ2 8IA8-C3a_B-E7 peptide-Gi1/β1/γ2
5.00	Consensus	cannabinoid_on	Orthosteric Ligand	cb2_on cb1_on
5.00	Consensus	cannabinoid_on_gp	Orthosteric Ligand	cb2_on_gp cb1_on_gp
5.00	Consensus	cb1_on	Orthosteric Ligand	6KPG-CB₁-AM841-Gi1/β1/γ2 8K8J-CB₁-Fenofibrate-chim(Gs-CtGq)/β1/γ2
5.00	Consensus	class-b1_on_gp	Orthosteric Ligand	glucagon_on_gp vip-pacap_on_gp pth_on_gp crf_on_gp calcitonin_on_gp
5.00	Consensus	galanin_on	Orthosteric Ligand	gal2_on gal1_on
5.00	Consensus	galanin_on_gp	Orthosteric Ligand	gal2_on_gp gal1_on_gp
5.00	Consensus	mop_on	Orthosteric Ligand	8F7R-μ-Endomorphin-Gi1/β1/γ2 8EF5-μ-Fentanyl-Gi1/β1/γ2 7SCG-μ-FH210-Gi1/β1/γ2 7T2H-μ-Lofentanil-Gi1/β1/γ2 7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2 8EF6-μ-Morphine-Gi1/β1/γ2 8EFB-μ-Oliceridine-Gi1/β1/γ2 7U2L-μ-PubChem 163201242-Gi1/β1/γ2 8EFO-μ-PZM21-Gi1/β1/γ2 8EFL-μ-SR17018-Gi1/β1/γ2 8F7Q-μ-β-Endorphin-Gi1/β1/γ2 7U2K-μ-C6-guano-Gi1/β1/γ2 8EFQ-μ-Damgo-Gi1/β1/γ2
5.00	Consensus	mop_on_gp	Orthosteric Ligand	8F7R-μ-Endomorphin-Gi1/β1/γ2 8EF5-μ-Fentanyl-Gi1/β1/γ2 7SCG-μ-FH210-Gi1/β1/γ2 7T2H-μ-Lofentanil-Gi1/β1/γ2 7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2 8EF6-μ-Morphine-Gi1/β1/γ2 8EFB-μ-Oliceridine-Gi1/β1/γ2 7U2L-μ-PubChem 163201242-Gi1/β1/γ2 8EFO-μ-PZM21-Gi1/β1/γ2 8EFL-μ-SR17018-Gi1/β1/γ2 8F7Q-μ-β-Endorphin-Gi1/β1/γ2 7U2K-μ-C6-guano-Gi1/β1/γ2 8EFQ-μ-Damgo-Gi1/β1/γ2
5.00	Consensus	nk1_off	Orthosteric Ligand	6HLP-NK₁-Netupitant 6HLO-NK₁-Aprepitant 6HLL-NK₁-CP99994 6E59-NK₁-L-760735
5.00	Consensus	s1p3_on	Orthosteric Ligand	7EW3-S1P₃-S1P-Gi1/β1/γ2 7EW4-S1P₃-CYM5541-Gi1/β1/γ2 7EW2-S1P₃-Fingolimod-Gi1/β1/γ2
4.76	Single	2YCZ	Iodocyanopindolol	2YCZ-β₁-Iodocyanopindolol
4.76	Single	4BVN	Cyanopindolol	4BVN-β₁-Cyanopindolol-Na
4.76	Single	4OR2	FITM	4OR2-mGlu1; mGlu1-FITM
4.76	Single	6BQG	Ergotamine	6BQG-5-HT_2C-Ergotamine
4.76	Single	6BQH	Ritanserin	6BQH-5-HT_2C-Ritanserin
4.76	Single	6H7L	Dobutamine	6H7L-β₁-Dobutamine
4.76	Single	6IBL	Arformoterol	6IBL-β₁-Arformoterol
4.76	Single	6TKO	Arformoterol	6TKO-β₁-Arformoterol-Arrestin2
4.76	Single	7JVR	Bromoergocryptine	7JVR-D₂-Bromoergocryptine-Gi1/β1/γ2
4.76	Single	7MBY	Cholecystokinin-8	7MBY-CCK_A-Cholecystokinin-8-chim(NtGi1L-Gs-CtGq)/β1/γ2
4.76	Single	7UM4	AS2674723	7UM4-5-HT_5A-AS2674723
4.76	Single	7VGY	2-Iodomelatonin	7VGY-MT₁-2-Iodomelatonin-Gi1/β1/γ2
4.76	Single	7VVN	PTH	7VVN-PTH1-PTH-Gs/β1/γ2
4.76	Single	7X2D	Tavapadon	7X2D-D₁-Tavapadon-Gs/β1/γ2
4.76	Single	7Y65	C5a peptide	7Y65-C5a₁-C5a peptide-Gi1/β1/γ2
4.76	Single	8E9X	2-Deoxycytidine	8E9X-M₄-2-Deoxycytidine-chim(NtGi1-Go)/β1/γ2
4.76	Single	8E9Y	Clozapine-N-oxide	8E9Y-M₃-Clozapine-N-oxide-chim(NtGi2L-Gs-CtGq)/β1/γ2
4.76	Single	8FX5	Xanomeline	8FX5-M₄-Xanomeline-Xanomeline-Gi1/β1/γ2
4.76	Single	8GUT	LEI-102	8GUT-CB₂-LEI-102-Gi1/β1/γ2
4.76	Single	8HN1	Toxin AdTx1	8HN1-Alpha1A-Toxin AdTx1
4.76	Single	8I95	EP54	8I95-C3a_B-EP54-Go/β1/γ2
4.76	Single	8J19	LY237	8J19-GPR84-LY237-Gi1/β1/γ2
4.76	Single	8T3O	TUG-891	8T3O-FFA4-TUG-891-chim(NtGi2L-Gs-CtGq)/β1/γ2
4.76	Single	8XGS	Metastin	8XGS-Kiss1-Metastin-chim(NtGi1-Gq)/β1/γ2
4.76	Single	8XJK	Cloprosetnol	8XJK-FP-alpha-Cloprosetnol-chim(NtGi1-Gs-CtGq)/β1/γ2
4.76	Single	8XJO	U46619	8XJO-TXA2-U46619-chim(NtGi1-Gs-CtGq)/β1/γ2
4.76	Single	9C0K	Exendin-4	9C0K-GLP-1-Exendin-4-Gs/β1/γ2
4.76	Single	9CGJ	C6-Quino	9CGJ-δ-C6-Quino-Gi1/β1/γ2
4.76	Single	9JH5	C16:0 Ceramide	9JH5-CysLT₂-C16:0 Ceramide-chim(NtGi1-Gs-CtGq)/β1/γ2
4.76	Single	9M54	Neuropeptide VF	9M54-NPFF2-Neuropeptide VF-Gi1/β1/γ2
4.76	Consensus	5ht2c_off	Orthosteric Ligand	6BQH-5-HT_2C-Ritanserin
4.76	Consensus	beta1_on	Orthosteric Ligand	8DCR-β₁-Dobutamine-Gs/β1/γ2 7S0F-β₁-Isoprenaline-Gi1/β1/γ2
4.76	Consensus	beta1_on_gp	Orthosteric Ligand	8DCR-β₁-Dobutamine-Gs/β1/γ2 7S0F-β₁-Isoprenaline-Gi1/β1/γ2
4.76	Consensus	c3a_on_gp	Orthosteric Ligand	8HK2-C3a_B-C3a anaphylatoxin-Gi1/β1/γ2 8IA8-C3a_B-E7 peptide-Gi1/β1/γ2
4.76	Consensus	cb1_on_gp	Orthosteric Ligand	6KPG-CB₁-AM841-Gi1/β1/γ2 8K8J-CB₁-Fenofibrate-chim(Gs-CtGq)/β1/γ2
4.76	Consensus	cck_on	Orthosteric Ligand	ccka_on cckb_on
4.76	Consensus	cck_on_gp	Orthosteric Ligand	ccka_on_gp cckb_on_gp
4.76	Consensus	chemerin_on	Orthosteric Ligand	cml1_on
4.76	Consensus	gal2_on	Orthosteric Ligand	7WQ4-GAL₂-Galanin-chim(NtGi1-Gs-CtGq)/β1/γ2 7XJL-GAL₂-Spexin-chim(NtGi2L-Gs-CtGq)/β1/γ2
4.76	Consensus	gal2_on_gp	Orthosteric Ligand	7WQ4-GAL₂-Galanin-chim(NtGi1-Gs-CtGq)/β1/γ2 7XJL-GAL₂-Spexin-chim(NtGi2L-Gs-CtGq)/β1/γ2
4.76	Consensus	nk2_on	Orthosteric Ligand	7XWO-NK₂-Neurokinin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
4.76	Consensus	peptide_off	Orthosteric Ligand	cck_off angiotensin_off bombesin_off endothelin_off ghrelin_off npy_off opioid_off orexin_off somatostatin_off tachykinin_off vasop-oxy_off neurotensin_off
4.76	Consensus	prostanoid_on	Orthosteric Ligand	tp_on fp-alpha_on
4.76	Consensus	prostanoid_on_gp	Orthosteric Ligand	tp_on_gp fp-alpha_on_gp
4.76	Consensus	tp_on	Orthosteric Ligand	8XJO-TXA2-U46619-chim(NtGi1-Gs-CtGq)/β1/γ2
4.76	Consensus	tp_on_gp	Orthosteric Ligand	8XJO-TXA2-U46619-chim(NtGi1-Gs-CtGq)/β1/γ2
4.55	Single	4UG2	CGS21680	4UG2-A_2A-CGS21680
4.55	Single	5ZTY	AM10257	5ZTY-CB₂-AM10257
4.55	Single	6C1Q	PMX53	6C1Q-C5a₁-PMX53-NDT9513727
4.55	Single	6OMM	WKYMVX	6OMM-FPR2-ALX-WKYMVX-Gi1/β1/γ2
4.55	Single	6PT3	DPI-287	6PT3-δ-DPI-287
4.55	Single	7F8W	Gastrin-17	7F8W-CCK_B-Gastrin-17-chim(NtGsL-Gq)/β1/γ2
4.55	Single	7SK9	CCX662	7SK9-ACKR3-CCX662
4.55	Single	7YAE	Octreotide	7YAE-SST2-Octreotide-Gi1/β1/γ2
4.55	Single	7YJ4	INSL5	7YJ4-RXFP4-INSL5-Gi2/β1/γ2
4.55	Single	8F7R	Endomorphin	8F7R-μ-Endomorphin-Gi1/β1/γ2
4.55	Single	8IA7	Cholecystokinin-8	8IA7-CCK_B-Cholecystokinin-8-chim(NtGi1L-Gq)/β1/γ2
4.55	Single	8JLR	A77636	8JLR-TA1-A77636-chim(NtGi1-Gs)/β1/γ2
4.55	Single	8X5Y	Astemizole	8X5Y-H₁-Astemizole
4.55	Single	8XQL	Cholesterol	8XQL-TAS2R14-Cholesterol-Aristolochic acid A-Gt3/β1/γ1
4.55	Single	8XQO	Cholesterol	8XQO-TAS2R14-Cholesterol-Aristolochic acid A-Gi1/β1/γ1
4.55	Single	8Z74	Agonistic antibody	8Z74-Apelin-Agonistic antibody
4.55	Single	9CM7	TUG-1375	9CM7-FFA2-TUG-1375-AZ-1729-Gi1/β1/γ2
4.55	Single	9IPV	JR14a	9IPV-C3a_B-JR14a-Gi1/β1/γ2
4.55	Single	9IPY	JR14a	9IPY-C3a_B-JR14a
4.55	Single	9JF4	PD168368	9JF4-BB₁-PD168368
4.55	Single	9JH6	C20:0 Ceramide	9JH6-CysLT₂-C20:0 Ceramide-chim(NtGi1-Gs-CtGq)/β1/γ2
4.55	Single	9NS9	TUG-1375	9NS9-FFA2-TUG-1375-Compound 187-Gi1/β1/γ2
4.55	Single	9V2N	Macimorelin	9V2N-Ghrelin-Macimorelin-chim(NtGi1-Gs-CtGq)/β1/γ2
4.55	Consensus	cb2_off	Orthosteric Ligand	5ZTY-CB₂-AM10257
4.55	Consensus	formylpeptide_on	Orthosteric Ligand	fpr2-alx_on fpr1-alx_on
4.55	Consensus	gq_cck	Orthosteric Ligand	8IA7-CCK_B-Cholecystokinin-8-chim(NtGi1L-Gq)/β1/γ2 7XOW-CCK_B-Gastrin-chim(NtGi1-Gq)/β1/γ2 7EZM-CCK_A-Cholecystokinin-8-chim(NtGsL-Gq)/β1/γ2 7F8W-CCK_B-Gastrin-17-chim(NtGsL-Gq)/β1/γ2
4.55	Consensus	kiss1_on	Orthosteric Ligand	8ZJD-Kiss1-Kisspeptin-10-chim(NtGi1-Gq)/β1/γ1
4.55	Consensus	kisspeptin_on	Orthosteric Ligand	kiss1_on
4.55	Consensus	ox2_on	Orthosteric Ligand	7L1V-OX₂-PubChem 155491009-chim(NtGi1-Gs-CtGq)/β1/γ2 7SQO-OX₂-TAK-925-Gi1/β1/γ2 7L1U-OX₂-Orexin-chim(NtGi1-Gs-CtGq)/β1/γ2
4.55	Consensus	ox2_on_gp	Orthosteric Ligand	7L1V-OX₂-PubChem 155491009-chim(NtGi1-Gs-CtGq)/β1/γ2 7SQO-OX₂-TAK-925-Gi1/β1/γ2 7L1U-OX₂-Orexin-chim(NtGi1-Gs-CtGq)/β1/γ2
4.35	Single	4IAR	Ergotamine	4IAR-5-HT_1B-Ergotamine
4.35	Single	6WIV	PubChem 52923113; PubChem 52924645	6WIV-GABA_B1, GABA_B2-PubChem 52923113; PubChem 52924645
4.35	Single	6X19	CHU-128	6X19-GLP-1-CHU-128-Gs/β1/γ2
4.35	Single	7F8X	NN9056	7F8X-CCK_A-NN9056
4.35	Single	7T6U	CGEN-855A	7T6U-FPR2-ALX-CGEN-855A-Gi1/β1/γ2
4.35	Single	7WVW	fMYFINILTL	7WVW-FPR2-ALX-fMYFINILTL-Gi2/β1/γ2
4.35	Single	7XAU	Octreotide	7XAU-SST2-Octreotide-Gi1/β1/γ2
4.35	Single	7XMR	Somatostatin-14	7XMR-SST2-Somatostatin-14-Gi1/β1/γ2
4.35	Single	8DCR	Dobutamine	8DCR-β₁-Dobutamine-Gs/β1/γ2
4.35	Single	8F7X	Nociceptin	8F7X-NOP-Nociceptin-Gi1/β1/γ2
4.35	Single	8IEI	A1LYA	8IEI-GPR156-A1LYA
4.35	Single	8IZB	Lysophosphatidylserine	8IZB-GPR174-Lysophosphatidylserine-Gs/β1/γ2
4.35	Single	8KIG	SHU9119	8KIG-MC₃-SHU9119-Ca
4.35	Single	8WKY	PG-934	8WKY-MC₄-PG-934
4.35	Single	8XFT	R-spondin-2	8XFT-LGR4-R-spondin-2-ZNRF3
4.35	Single	8Y69	R-spondin-2	8Y69-LGR4-R-spondin-2-ZNRF3
4.35	Single	8ZBJ	Somatostatin-14	8ZBJ-SST5-Somatostatin-14-Gi1/β1/γ2
4.35	Single	8ZJD	Kisspeptin-10	8ZJD-Kiss1-Kisspeptin-10-chim(NtGi1-Gq)/β1/γ1
4.35	Single	8ZSP	LSD	8ZSP-TA1-LSD-chim(NtGi1L-Gs-CtGq)/β1/γ2
4.35	Single	9HB3	Mambaquaretin-1	9HB3-V₂-Mambaquaretin-1
4.35	Single	9M4T	Silodosin	9M4T-Alpha1A-Silodosin
4.35	Consensus	chemerin_on_gp	Orthosteric Ligand	cml1_on_gp
4.35	Consensus	cml1_on	Orthosteric Ligand	7YKD-CML1-Chemerin-9-Gi1/β1/γ2
4.35	Consensus	gi_chemerin	Orthosteric Ligand	7YKD-CML1-Chemerin-9-Gi1/β1/γ2
4.35	Consensus	gq_kisspeptin	Orthosteric Ligand	8ZJD-Kiss1-Kisspeptin-10-chim(NtGi1-Gq)/β1/γ1
4.35	Consensus	kiss1_on_gp	Orthosteric Ligand	8ZJD-Kiss1-Kisspeptin-10-chim(NtGi1-Gq)/β1/γ1
4.35	Consensus	kisspeptin_on_gp	Orthosteric Ligand	kiss1_on_gp
4.35	Consensus	nop_on	Orthosteric Ligand	8F7X-NOP-Nociceptin-Gi1/β1/γ2
4.35	Consensus	nop_on_gp	Orthosteric Ligand	8F7X-NOP-Nociceptin-Gi1/β1/γ2
4.35	Consensus	somatostatin_off	Orthosteric Ligand	sst2_off
4.17	Single	7E14	Orforglipron	7E14-GLP-1-Orforglipron-PubChem 156022738-Gs/β1/γ2
4.17	Single	7WJ5	Somatostatin-14	7WJ5-SST2-Somatostatin-14-Gi1/β1/γ2
4.17	Single	7XMS	Somatostatin-14	7XMS-SST4-Somatostatin-14-Gi1/β1/γ2
4.17	Single	8JBH	Substance-P	8JBH-NK₃-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
4.17	Single	8KH5	Lysophosphatidylserine	8KH5-GPR174-Lysophosphatidylserine-Gs/β1/γ2
4.17	Single	8WSS	Pro-MCH	8WSS-MCH1-Pro-MCH-Gi1/β1/γ1
4.17	Single	9IK8	SST analogue	9IK8-SST1-SST analogue-Gi1/β1/γ2
4.17	Single	9IQV	Muscarinic toxin 3	9IQV-Alpha1A-Muscarinic toxin 3
4.17	Consensus	cckb_on	Orthosteric Ligand	8IA7-CCK_B-Cholecystokinin-8-chim(NtGi1L-Gq)/β1/γ2 7XOW-CCK_B-Gastrin-chim(NtGi1-Gq)/β1/γ2 7F8V-CCK_B-Gastrin-17-Gi2/β1/γ2
4.17	Consensus	formylpeptide_on_gp	Orthosteric Ligand	fpr2-alx_on_gp fpr1-alx_on_gp
4.17	Consensus	gi_cck	Orthosteric Ligand	7EZH-CCK_A-Cholecystokinin-8-Gi1/β1/γ2 7F8V-CCK_B-Gastrin-17-Gi2/β1/γ2
4.00	Single	6PT2	KGCHM07	6PT2-δ-KGCHM07
4.00	Single	6VN7	PACAP	6VN7-VPAC₁-PACAP-Gs/β1/γ2
4.00	Single	6W25	SHU9119	6W25-MC₄-SHU9119-Ca
4.00	Single	7W55	Neuromedin-U-25	7W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
4.00	Single	7XOU	Cholecystokinin-8	7XOU-CCK_A-Cholecystokinin-8-Gs/β1/γ2
4.00	Single	8WVU	R-spondin-1	8WVU-LGR4-R-spondin-1-RNF43
4.00	Single	8XGU	TAK448	8XGU-Kiss1-TAK448-Gi1/β1/γ2
4.00	Single	8XIR	Pasireotide	8XIR-SST3-Pasireotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
4.00	Single	8Y69	R-spondin-2	8Y69-LGR4-R-spondin-2-ZNRF3
4.00	Single	9B5Y	Long-Acting PTH	9B5Y-PTH1-Long-Acting PTH-chim(NtGi1-Gq)/β1/γ2
4.00	Consensus	cckb_on_gp	Orthosteric Ligand	8IA7-CCK_B-Cholecystokinin-8-chim(NtGi1L-Gq)/β1/γ2 7XOW-CCK_B-Gastrin-chim(NtGi1-Gq)/β1/γ2 7F8V-CCK_B-Gastrin-17-Gi2/β1/γ2
4.00	Consensus	fpr2-alx_on	Orthosteric Ligand	7WVX-FPR2-ALX-Humanin-Gi2/β1/γ2 7T6U-FPR2-ALX-CGEN-855A-Gi1/β1/γ2 7T6V-FPR2-ALX-fMLFII-Gi1/β1/γ2 7WVY-FPR2-ALX-Amyloid-β42-Gi2/β1/γ2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/β1/γ2 6OMM-FPR2-ALX-WKYMVX-Gi1/β1/γ2
4.00	Consensus	nmur2_on	Orthosteric Ligand	7W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
4.00	Consensus	nmur2_on_gp	Orthosteric Ligand	7W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
4.00	Consensus	peptide_offon	Orthosteric Ligand	peptide_off peptide_on
3.85	Single	6NIY	Adrenomedullin	6NIY-CT-Adrenomedullin-Gs/β1/γ2
3.85	Single	6WIV	PubChem 52923113; PubChem 52924645	6WIV-GABA_B1, GABA_B2-PubChem 52923113; PubChem 52924645
3.85	Single	7AD3	Alpha-factor mating pheromone	7AD3-STE2-α-factor mating pheromone-Gi1/STE4/γ2
3.85	Single	7V9M	Somatoliberin	7V9M-GHRH (SV1)-Somatoliberin-Gs/β1/γ2
3.85	Single	7W40	Bombesin	7W40-BB₂-Bombesin-chim(NtGi1L-Gq)/β1/γ2
3.85	Single	7W57	Neuromedin-S	7W57-NMUR2-Neuromedin-S-chim(NtGi1-Gs-CtGq)/β1/γ2
3.85	Single	7XK8	Neuromedin-U-25	7XK8-NMUR2-Neuromedin-U-25-Gi1/β1/γ2
3.85	Single	8XFP	R-spondin-2	8XFP-LGR4-R-spondin-2-ZNRF3
3.85	Consensus	apelin_on	Orthosteric Ligand	8XZH-Apelin-MM07-Gi1/β1/γ2 7W0M-Apelin-PubChem 122701908-Gi1/β1/γ2 8XZJ-Apelin-WN353-Gi1/β1/γ2 8XZF-Apelin-WN561-Gi1/β1/γ2 8XZG-Apelin-Apelin-13-Gi1/β1/γ2
3.85	Consensus	apelin_on_gp	Orthosteric Ligand	8XZH-Apelin-MM07-Gi1/β1/γ2 7W0M-Apelin-PubChem 122701908-Gi1/β1/γ2 8XZJ-Apelin-WN353-Gi1/β1/γ2 8XZF-Apelin-WN561-Gi1/β1/γ2 8XZG-Apelin-Apelin-13-Gi1/β1/γ2
3.85	Consensus	fpr2-alx_on_gp	Orthosteric Ligand	7WVX-FPR2-ALX-Humanin-Gi2/β1/γ2 7T6U-FPR2-ALX-CGEN-855A-Gi1/β1/γ2 7T6V-FPR2-ALX-fMLFII-Gi1/β1/γ2 7WVY-FPR2-ALX-Amyloid-β42-Gi2/β1/γ2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/β1/γ2 6OMM-FPR2-ALX-WKYMVX-Gi1/β1/γ2
3.85	Consensus	neuromedin-u_on	Orthosteric Ligand	nmur1_on nmur2_on
3.85	Consensus	peptide_offon_gp	Orthosteric Ligand	peptide_on_gp peptide_off
3.70	Single	7XV3	Lysophosphatidylserine	7XV3-GPR174-Lysophosphatidylserine-chim(NtGi1-Gs)/β1/γ2
3.70	Single	8IOD	PG-901	8IOD-MC₅-PG-901-Ca-chim(NtGi1-Gs)/β1/γ2
3.70	Single	8WWK	MCH	8WWK-MCH1-MCH-Gi1/β1/γ2
3.70	Single	8WWM	MCH	8WWM-MCH1-MCH-Gi1/β1/γ2
3.70	Single	8XGO	TAK448	8XGO-Kiss1-TAK448-chim(NtGi1-Gq)/β1/γ2
3.70	Consensus	cml1_on_gp	Orthosteric Ligand	7YKD-CML1-Chemerin-9-Gi1/β1/γ2
3.57	Single	6P9Y	PACAP	6P9Y-PAC₁-PACAP-Gs/β1/γ2
3.57	Single	7CZ5	Somatoliberin	7CZ5-GHRH-Somatoliberin-Gs/β1/γ2
3.57	Single	7D3S	Secretin	7D3S-Secretin-Secretin-Gs/β1/γ2
3.57	Single	7F8V	Gastrin-17	7F8V-CCK_B-Gastrin-17-Gi2/β1/γ2
3.57	Single	7W3Z	Gastrin Releasing Peptide	7W3Z-BB₂-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/β1/γ2
3.57	Single	7YKD	Chemerin-9	7YKD-CML1-Chemerin-9-Gi1/β1/γ2
3.57	Single	8H0P	NMB30	8H0P-BB₁-NMB30-chim(NtGi1-Gs-CtGq)/β1/γ2
3.57	Consensus	secretin_on	Orthosteric Ligand	7D3S-Secretin-Secretin-Gs/β1/γ2
3.45	Single	6P9X	Corticoliberin	6P9X-CRF₁-Corticoliberin-Gs/β1/γ2
3.45	Single	8WWL	MCH	8WWL-MCH1-MCH-Gi1/β1/γ2
3.45	Single	8XFS	R-spondin-2	8XFS-LGR4-R-spondin-2-ZNRF3
3.45	Consensus	secretin_on_gp	Orthosteric Ligand	7D3S-Secretin-Secretin-Gs/β1/γ2
3.33	Single	6PB1	Urocortin	6PB1-CRF₂-Urocortin-chim(NtGi1-Gs)/β1/γ2
3.33	Single	8FLT	M-PTH(1-14)	8FLT-PTH1-M-PTH(1-14)-Gs/β1/γ2
3.33	Single	8WWN	MCH	8WWN-MCH1-MCH-Gi1/β1/γ2
3.33	Single	8Y52	BA1	8Y52-BB₃-BA1-chim(NtGi1-Gs-CtGq)/β1/γ2
3.23	Single	6PB0	Urocortin	6PB0-CRF₁-Urocortin-chim(NtGi1-Gs)/β1/γ2
3.23	Single	8ZJE	TAK-448	8ZJE-Kiss1-TAK-448-chim(NtGi1-Gq)/β1/γ1
3.23	Consensus	bb2_on	Orthosteric Ligand	7W40-BB₂-Bombesin-chim(NtGi1L-Gq)/β1/γ2 7W3Z-BB₂-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/β1/γ2
3.23	Consensus	bb2_on_gp	Orthosteric Ligand	7W40-BB₂-Bombesin-chim(NtGi1L-Gq)/β1/γ2 7W3Z-BB₂-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/β1/γ2
3.23	Consensus	bombesin_on	Orthosteric Ligand	bb2_on
3.23	Consensus	bombesin_on_gp	Orthosteric Ligand	bb2_on_gp
3.23	Consensus	gq_bombesin	Orthosteric Ligand	7W40-BB₂-Bombesin-chim(NtGi1L-Gq)/β1/γ2 7W3Z-BB₂-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/β1/γ2

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:D68	R:R:S69	5.89	1	Yes	Yes	6	7	1	2
R:R:D68	R:R:K78	9.68	1	Yes	No	6	5	1	2
R:R:D68	R:R:Y103	11.49	1	Yes	Yes	6	7	1	2
R:R:D68	R:R:F139	9.55	1	Yes	Yes	6	8	1	2
R:R:D68	W:W:?3	4.35	1	Yes	Yes	6	0	1	0
R:R:K78	R:R:S69	6.12	1	No	Yes	5	7	2	2
R:R:K78	R:R:Y103	7.17	1	No	Yes	5	7	2	2
R:R:L81	W:W:?3	6.66	0	No	Yes	4	0	1	0
R:R:I95	R:R:W82	3.52	1	Yes	Yes	8	7	2	1
R:R:L99	R:R:W82	12.53	1	No	Yes	9	7	2	1
R:R:W82	R:R:Y103	7.72	1	Yes	Yes	7	7	1	2
R:R:V130	R:R:W82	3.68	1	No	Yes	7	7	1	1
R:R:W136	R:R:W82	3.75	1	Yes	Yes	9	7	2	1
R:R:P137	R:R:W82	4.05	1	Yes	Yes	9	7	1	1
R:R:L140	R:R:W82	3.42	1	Yes	Yes	7	7	2	1
R:R:W82	W:W:?3	8.22	1	Yes	Yes	7	0	1	0
R:R:I95	R:R:L99	7.14	1	Yes	No	8	9	2	2
R:R:F139	R:R:Y103	5.16	1	Yes	Yes	8	7	2	2
R:R:E133	R:R:I129	10.93	0	No	No	4	6	1	2
R:R:V130	R:R:W136	15.94	1	No	Yes	7	9	1	2
R:R:V130	W:W:?3	3.58	1	No	Yes	7	0	1	0
R:R:E133	W:W:?3	18.07	0	No	Yes	4	0	1	0
R:R:R134	W:W:?3	8.77	0	No	Yes	5	0	1	0
R:R:P137	R:R:W136	5.4	1	Yes	Yes	9	9	1	2
R:R:L140	R:R:W136	4.56	1	Yes	Yes	7	9	2	2
R:R:F139	R:R:P137	5.78	1	Yes	Yes	8	9	2	1
R:R:L140	R:R:P137	13.14	1	Yes	Yes	7	9	2	1
R:R:P137	W:W:?3	6.58	1	Yes	Yes	9	0	1	0
R:R:F139	R:R:L140	7.31	1	Yes	Yes	8	7	2	2

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

Similarity	Network Type	Name	Ligand	Description
100.00	Single	6D35	Cholesterol	6D35-SMO-Cholesterol
100.00	Single	6N51	Quisqualate	6N51-mGlu5; mGlu5-Quisqualate
100.00	Single	6N51	Quisqualate	6N51-mGlu5; mGlu5-Quisqualate
100.00	Single	6UO8	SKF97541	6UO8-GABA_B1, GABA_B2-SKF97541-GS39783
100.00	Single	6UO9	SKF97541	6UO9-GABA_B1, GABA_B2-SKF97541
100.00	Single	6W2X	PubChem 5311042	6W2X-GABA_B1, GABA_B2-PubChem 5311042
100.00	Single	6W2Y	PubChem 5311042	6W2Y-GABAB1; GABAB1-PubChem 5311042
100.00	Single	6W2Y	PubChem 5311042	6W2Y-GABAB1; GABAB1-PubChem 5311042
100.00	Single	7C7Q	Baclofen	7C7Q-GABA_B1, GABA_B2-Baclofen-BHFF
100.00	Single	7C7S	CGP54626	7C7S-GABA_B1, GABA_B2-CGP54626
100.00	Single	7CUM	CGP54626	7CUM-GABA_B1, GABA_B2-CGP54626
100.00	Single	7DD5	Ca	7DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
100.00	Single	7DD5	Ca; Ca; Tryptophan; NPS-2143	7DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
100.00	Single	7DD5	Ca	7DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
100.00	Single	7DD5	Ca; Ca; Tryptophan; NPS-2143	7DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
100.00	Single	7DGE	Quisqualate	7DGE-mGlu1; mGlu1-Quisqualate
100.00	Single	7DTT	Ca	7DTT-CaS-Ca-Ca
100.00	Single	7DTT	Ca	7DTT-CaS-Ca-Ca
100.00	Single	7DTU	Tryptophan	7DTU-CaS-Tryptophan
100.00	Single	7DTU	Tryptophan	7DTU-CaS-Tryptophan
100.00	Single	7DTV	Ca	7DTV-CaS-Ca-Ca; Tryptophan
100.00	Single	7DTV	Ca; Tryptophan	7DTV-CaS-Ca-Ca; Tryptophan
100.00	Single	7DTV	Ca	7DTV-CaS-Ca-Ca; Tryptophan
100.00	Single	7DTV	Ca; Tryptophan	7DTV-CaS-Ca-Ca; Tryptophan
100.00	Single	7E6T	Ca	7E6T-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
100.00	Single	7E6T	Ca; Ca; Cyclomethyltryptophan; PO4	7E6T-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
100.00	Single	7E6T	Ca	7E6T-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
100.00	Single	7E6T	Ca; Ca; Cyclomethyltryptophan; PO4	7E6T-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
100.00	Single	7E9G	Eglumetad	7E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/β1/γ2
100.00	Single	7E9G	Eglumetad	7E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/β1/γ2
100.00	Single	7E9H	Phosphoserine	7E9H-mGlu4; mGlu4-Phosphoserine-Gi3/β1/γ2
100.00	Single	7E9H	Phosphoserine	7E9H-mGlu4; mGlu4-Phosphoserine-Gi3/β1/γ2
100.00	Single	7EB2	Baclofen	7EB2-GABAB2; GABAB1-Baclofen-rac-BHFF-Gi1/β1/γ2
100.00	Single	7EPB	Eglumetad	7EPB-mGlu2; mGlu2-Eglumetad
100.00	Single	7EPB	Eglumetad	7EPB-mGlu2; mGlu2-Eglumetad
100.00	Single	7FD8	Quisqualate	7FD8-mGlu5; mGlu5-Quisqualate
100.00	Single	7FD8	Quisqualate	7FD8-mGlu5; mGlu5-Quisqualate
100.00	Single	7FD9	LY341495	7FD9-mGlu5; mGlu5-LY341495
100.00	Single	7FD9	LY341495	7FD9-mGlu5; mGlu5-LY341495
100.00	Single	7FIH	hCG	7FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/β1/γ2
100.00	Single	7FII	hCG	7FII-LH-hCG-chim(NtGi1-Gs)/β1/γ2
100.00	Single	7M3E	Ca; Ca; Tryptophan; NPS-2143	7M3E-CaS-Ca; Ca; Tryptophan; NPS-2143
100.00	Single	7M3E	Ca; Ca; Tryptophan; NPS-2143	7M3E-CaS-Ca; Ca; Tryptophan; NPS-2143
100.00	Single	7M3F	Ca; Ca; Tryptophan; Cinacalcet; PO4	7M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
100.00	Single	7M3F	Ca; Ca; Tryptophan; Cinacalcet; PO4	7M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
100.00	Single	7M3G	Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4	7M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
100.00	Single	7M3G	Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4	7M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
100.00	Single	7M3G	Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4	7M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
100.00	Single	7M3G	Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4	7M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
100.00	Single	7MTQ	LY341495	7MTQ-mGlu2; mGlu2-LY341495
100.00	Single	7MTQ	LY341495	7MTQ-mGlu2; mGlu2-LY341495
100.00	Single	7MTR	Glutamate	7MTR-mGlu2; mGlu2-Glutamate-ADX55164
100.00	Single	7MTR	Glutamate	7MTR-mGlu2; mGlu2-Glutamate-ADX55164
100.00	Single	7MTS	Glutamate	7MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/β1/γ2
100.00	Single	7MTS	Glutamate	7MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/β1/γ2
100.00	Single	7SIL	Ca	7SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
100.00	Single	7SIL	Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4	7SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
100.00	Single	7SIL	Ca	7SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
100.00	Single	7SIL	Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4	7SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
100.00	Single	7SIM	Ca	7SIM-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
100.00	Single	7SIM	Ca; Ca; Cyclomethyltryptophan; PO4	7SIM-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
100.00	Single	7SIM	Ca	7SIM-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
100.00	Single	7SIM	Ca; Ca; Cyclomethyltryptophan; PO4	7SIM-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
100.00	Single	7T9N	M22 Fab	7T9N-TSH-M22 Fab-DPPC-Gs/β1/γ2
100.00	Single	7WI6	LY341495	7WI6-mGlu3; mGlu3-LY341495
100.00	Single	7WI6	LY341495	7WI6-mGlu3; mGlu3-LY341495
100.00	Single	7WI8	LY341495	7WI8-mGlu3; mGlu3-LY341495
100.00	Single	7WI8	LY341495	7WI8-mGlu3; mGlu3-LY341495
100.00	Single	7WIH	LY2794193	7WIH-mGlu3; mGlu3-LY2794193
100.00	Single	7WIH	LY2794193	7WIH-mGlu3; mGlu3-LY2794193
100.00	Single	7XW6	M22 Fab	7XW6-TSH-M22 Fab-ML109-Gs/β1/γ2
100.00	Single	7XW7	K1-70	7XW7-TSH-K1-70
100.00	Single	8JCU	LY341495	8JCU-mGlu2; mGlu3-LY341495
100.00	Single	8JCU	LY341495	8JCU-mGlu2; mGlu3-LY341495
100.00	Single	8JCV	LY341495	8JCV-mGlu2; mGlu3-LY341495
100.00	Single	8JCV	LY341495	8JCV-mGlu2; mGlu3-LY341495
100.00	Single	8JCW	LY341495	8JCW-mGlu2; mGlu3-LY341495
100.00	Single	8JCW	LY341495	8JCW-mGlu2; mGlu3-LY341495
100.00	Single	8JCX	LY341495	8JCX-mGlu2; mGlu3-LY341495
100.00	Single	8JCX	LY341495	8JCX-mGlu2; mGlu3-LY341495
100.00	Single	8JCY	LY341495	8JCY-mGlu2; mGlu3-LY341495
100.00	Single	8JCY	LY341495	8JCY-mGlu2; mGlu3-LY341495
100.00	Single	8JCZ	LY341495	8JCZ-mGlu2; mGlu3-LY341495
100.00	Single	8JCZ	LY341495	8JCZ-mGlu2; mGlu3-LY341495
100.00	Single	8JD0	Glutamate	8JD0-mGlu2; mGlu3-Glutamate-NAM563
100.00	Single	8JD1	Glutamate	8JD1-mGlu2; mGlu3-Glutamate
100.00	Single	8JD1	Glutamate	8JD1-mGlu2; mGlu3-Glutamate
100.00	Single	8JD2	Glutamate	8JD2-mGlu2; mGlu3-Glutamate
100.00	Single	8JD2	Glutamate	8JD2-mGlu2; mGlu3-Glutamate
100.00	Single	8JD3	Glutamate	8JD3-mGlu2; mGlu3-Glutamate-JNJ-40411813-Gi1/β1/γ2
100.00	Single	8JD3	Glutamate	8JD3-mGlu2; mGlu3-Glutamate-JNJ-40411813-Gi1/β1/γ2
100.00	Single	8JD4	Glutamate	8JD4-mGlu2; mGlu4-Glutamate
100.00	Single	8JD4	Glutamate	8JD4-mGlu2; mGlu4-Glutamate
100.00	Single	8JD5	Glutamate	8JD5-mGlu2; mGlu4-Glutamate-JNJ-40411813; ADX88178-Gi1/β1/γ2
100.00	Single	8JD5	Glutamate	8JD5-mGlu2; mGlu4-Glutamate-JNJ-40411813; ADX88178-Gi1/β1/γ2
100.00	Single	8JD6	Phosphoserine	8JD6-mGlu4; mGlu4-Phosphoserine-VU0364770-Gi3/β1/γ2
100.00	Single	8JD6	Phosphoserine	8JD6-mGlu4; mGlu4-Phosphoserine-VU0364770-Gi3/β1/γ2
100.00	Single	8SZF	Ca; Ca; Tryptophan; Cinacalcet; PO4; Spermine	8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; Spermine
100.00	Single	8SZF	Ca; Ca; Tryptophan; Cinacalcet; PO4; Spermine	8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; Spermine
100.00	Single	8SZG	Ca; Ca; Tryptophan; Cinacalcet; PO4; Spermine	8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; Spermine-chim(NtGi1-Gq)/β1/γ2
100.00	Single	8T7H	Quisqualate	8T7H-mGlu5; mGlu5-Quisqualate
100.00	Single	8T7H	Quisqualate	8T7H-mGlu5; mGlu5-Quisqualate
100.00	Single	8T8M	Quisqualate	8T8M-mGlu5; mGlu5-Quisqualate
100.00	Single	8T8M	Quisqualate	8T8M-mGlu5; mGlu5-Quisqualate
100.00	Single	8TAO	Quisqualate	8TAO-mGlu5; mGlu5-Quisqualate-CDPPB
100.00	Single	8TAO	Quisqualate	8TAO-mGlu5; mGlu5-Quisqualate-CDPPB
100.00	Single	8TQB	Ca; PAM VU6023326	8TQB-mGlu3; mGlu3-Ca; PAM VU6023326-Ca
100.00	Single	8TQB	Ca; PAM VU6023326	8TQB-mGlu3; mGlu3-Ca; PAM VU6023326-Ca
100.00	Single	8TR0	LY341495	8TR0-mGlu3; mGlu3-LY341495
100.00	Single	8TR0	LY341495	8TR0-mGlu3; mGlu3-LY341495
100.00	Single	8TR2	Ca; LY379268	8TR2-mGlu3; mGlu3-Ca; LY379268-Ca
100.00	Single	8TR2	Ca; LY379268	8TR2-mGlu3; mGlu3-Ca; LY379268-Ca
100.00	Single	8TRC	LY341495	8TRC-mGlu3; mGlu3-LY341495
100.00	Single	8TRC	LY341495	8TRC-mGlu3; mGlu3-LY341495
100.00	Single	8TRD	LY341495	8TRD-mGlu3; mGlu3-LY341495
100.00	Single	8TRD	LY341495	8TRD-mGlu3; mGlu3-LY341495
100.00	Single	8WG9	(2S)-2-amino-4-phosphonobutanoic acid	8WG9-mGlu4; mGlu2-(2S)-2-amino-4-phosphonobutanoic acid
100.00	Single	8WGB	Glutammate	8WGB-mGlu4; mGlu2-Glutammate-VU0155041-Gi3/β1/γ2
100.00	Single	8WGB	Glutammate	8WGB-mGlu4; mGlu2-Glutammate-VU0155041-Gi3/β1/γ2
100.00	Single	8WGC	LY379268	8WGC-mGlu4; mGlu2-LY379268
100.00	Single	8WGD	WAG; WA6	8WGD-mGlu4; mGlu2-WAG; WA6
100.00	Single	8WGD	WAG; WA6	8WGD-mGlu4; mGlu2-WAG; WA6
100.00	Single	8WPG	Tryptophan; Cinacalcet; PO4; Ca	8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
100.00	Single	8WPG	Tryptophan; Cinacalcet; PO4; Ca	8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
100.00	Single	8WPU	Tryptophan; Cinacalcet; PO4; Ca	8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/β1/γ2
100.00	Single	8WPU	Tryptophan; Cinacalcet; PO4; Ca	8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/β1/γ2
100.00	Single	8WVX	Norrin	8WVX-LGR4-Norrin
100.00	Single	8WVY	Norrin	8WVY-LGR4-Norrin
100.00	Single	8X0B	Quisqualate	8X0B-mGlu5; mGlu5-Quisqualate-VU0424465
100.00	Single	8X0B	Quisqualate	8X0B-mGlu5; mGlu5-Quisqualate-VU0424465
100.00	Single	8X0C	Quisqualate	8X0C-mGlu5; mGlu5-Quisqualate-VU0424465
100.00	Single	8X0C	Quisqualate	8X0C-mGlu5; mGlu5-Quisqualate-VU0424465
100.00	Single	8X0D	Quisqualate	8X0D-mGlu5; mGlu5-Quisqualate-VU0424465
100.00	Single	8X0D	Quisqualate	8X0D-mGlu5; mGlu5-Quisqualate-VU0424465
100.00	Single	8X0E	Quisqualate	8X0E-mGlu5; mGlu5-Quisqualate
100.00	Single	8X0E	Quisqualate	8X0E-mGlu5; mGlu5-Quisqualate
100.00	Single	8X0F	Quisqualate	8X0F-mGlu5; mGlu5-Quisqualate-VU0424465
100.00	Single	8X0F	Quisqualate	8X0F-mGlu5; mGlu5-Quisqualate-VU0424465
100.00	Single	8X0G	Quisqualate	8X0G-mGlu5; mGlu5-Quisqualate
100.00	Single	8X0G	Quisqualate	8X0G-mGlu5; mGlu5-Quisqualate
100.00	Single	8X0H	Quisqualate	8X0H-mGlu5; mGlu5-Quisqualate
100.00	Single	8X0H	Quisqualate	8X0H-mGlu5; mGlu5-Quisqualate
100.00	Single	8XUM	R-spondin-2	8XUM-LGR4-R-spondin-2
100.00	Single	9ASB	Ca	9ASB-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
100.00	Single	9ASB	Ca; Ca; Cyclomethyltryptophan; 9IG; PO4	9ASB-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
100.00	Single	9AVG	Ca	9AVG-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs)/β1/γ2
100.00	Single	9AVG	Ca; Ca; Cyclomethyltryptophan; 9IG; PO4	9AVG-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs)/β1/γ2
100.00	Single	9AVL	Ca	9AVL-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi3/β2/γ2
100.00	Single	9AVL	Ca; Ca; Cyclomethyltryptophan; 9IG; PO4	9AVL-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi3/β2/γ2
100.00	Single	9AVL	Ca	9AVL-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi3/β2/γ2
100.00	Single	9AVL	Ca; Ca; Cyclomethyltryptophan; 9IG; PO4	9AVL-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi3/β2/γ2
100.00	Single	9AXF	Ca	9AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
100.00	Single	9AXF	Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4	9AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
100.00	Single	9AXF	Ca	9AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
100.00	Single	9AXF	Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4	9AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
100.00	Single	9AYF	Ca	9AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/β1/γ2
100.00	Single	9AYF	Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4	9AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/β1/γ2
100.00	Single	9C1P	Ca	9C1P-CaS-Ca-Ca; Tryptophan; '6218; PO4
100.00	Single	9C1P	Ca; Tryptophan; '6218; PO4	9C1P-CaS-Ca-Ca; Tryptophan; '6218; PO4
100.00	Single	9C1P	Ca	9C1P-CaS-Ca-Ca; Tryptophan; '6218; PO4
100.00	Single	9C1P	Ca; Tryptophan; '6218; PO4	9C1P-CaS-Ca-Ca; Tryptophan; '6218; PO4
100.00	Single	9C2F	Ca	9C2F-CaS-Ca-Ca; Ca; Tryptophan; '54149; PO4
100.00	Single	9C2F	Ca; Ca; Tryptophan; '54149; PO4	9C2F-CaS-Ca-Ca; Ca; Tryptophan; '54149; PO4
100.00	Single	9C2F	Ca	9C2F-CaS-Ca-Ca; Ca; Tryptophan; '54149; PO4
100.00	Single	9C2F	Ca; Ca; Tryptophan; '54149; PO4	9C2F-CaS-Ca-Ca; Ca; Tryptophan; '54149; PO4
100.00	Single	9II2	Glutamate	9II2-mGlu3; mGlu3-Glutamate-Arrestin2
100.00	Single	9II2	Glutamate	9II2-mGlu3; mGlu3-Glutamate-Arrestin2
100.00	Single	9II3	Glutamate	9II3-mGlu3; mGlu3-Glutamate-Arrestin2
100.00	Single	9II3	Glutamate	9II3-mGlu3; mGlu3-Glutamate-Arrestin2
100.00	Single	9KHH	Norrin	9KHH-LGR4-Norrin
100.00	Single	9S37	NB21	9S37-LGR4-NB21
100.00	Single	9UTB	Sucralose	9UTB-TAS1R2; TAS1R3-Sucralose
50.00	Single	7DD6	Ca	7DD6-CaS-Ca-Ca; Ca; Tryptophan
50.00	Single	7DD6	Ca; Ca; Tryptophan	7DD6-CaS-Ca-Ca; Ca; Tryptophan
50.00	Single	7DD6	Ca	7DD6-CaS-Ca-Ca; Ca; Tryptophan
50.00	Single	7DD6	Ca; Ca; Tryptophan	7DD6-CaS-Ca-Ca; Ca; Tryptophan
50.00	Single	7DD7	Ca	7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
50.00	Single	7DD7	Ca; Ca; Tryptophan; Evocalcet	7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
50.00	Single	7DD7	Ca	7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
50.00	Single	7DD7	Ca; Ca; Tryptophan; Evocalcet	7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
50.00	Single	8SZF	Ca; Ca; Tryptophan; Cinacalcet; PO4; Spermine	8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; Spermine
50.00	Single	8SZF	Ca; Ca; Tryptophan; Cinacalcet; PO4; Spermine	8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; Spermine
50.00	Single	9ASB	Ca	9ASB-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
50.00	Single	9ASB	Ca; Ca; Cyclomethyltryptophan; 9IG; PO4	9ASB-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
50.00	Single	9AVG	Ca	9AVG-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs)/β1/γ2
50.00	Single	9AVG	Ca; Ca; Cyclomethyltryptophan; 9IG; PO4	9AVG-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs)/β1/γ2
50.00	Single	9AYF	Ca	9AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/β1/γ2
50.00	Single	9AYF	Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4	9AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/β1/γ2
33.33	Single	7KNU	Calcitonin gene-related peptide-1	7KNU-CT Like-Calcitonin gene-related peptide-1-RAMP1
33.33	Single	7T9M	CS-17 Antibody	7T9M-TSH-CS-17 Antibody
25.00	Single	6O3C	Cholesterol	6O3C-SMO-SAG21k-Cholesterol
25.00	Single	7FIG	hCG	7FIG-LH-hCG-chim(NtGi1L-Gs)/β1/γ2
25.00	Single	7UTZ	TR1402	7UTZ-TSH-TR1402-DPPC-Gs/β1/γ2
25.00	Single	7XW5	TSH	7XW5-TSH-TSH-ML109-Gs/β1/γ2
25.00	Single	7ZI0	Cholesterol	7ZI0-SMO-SAG-Cholesterol
20.00	Single	5L7D	Cholesterol	5L7D-SMO-Cholesterol
20.00	Single	7T9I	TSH	7T9I-TSH-TSH-Gs/β1/γ2
20.00	Single	8HS2	Fab046	8HS2-GPR20-Fab046
20.00	Single	8I2G	Glycoprotein hormones alpha chain	8I2G-FSH-Glycoprotein hormones α chain-Compound 716340-Gs/β1/γ2
20.00	Single	8X9S	5alpha-DHT	8X9S-ADGRD1-5α-DHT-chim(NtGi1-Gs)/β1/γ2
20.00	Single	9IV2	5alpha-DHT	9IV2-ADGRD1-5α-DHT-chim(NtGi1-Gs)/β1/γ2
16.67	Single	6XBM	5LWE	6XBM-SMO-5LWE-Gi1/β1/γ2
16.67	Single	8U4Q	REGN7663-Fab	8U4Q-CXCR4-REGN7663-Fab-Gi1/β1/γ2
16.67	Consensus	p2y_off	Orthosteric Ligand	p2y1_off
14.29	Single	4XNW	MRS2500	4XNW-P2Y₁-MRS2500
14.29	Single	6D32	Cyclopamine	6D32-SMO-Cyclopamine-Cyclopamine
14.29	Single	8JEF	(3S)-3-hydroxyoctanoic acid	8JEF-HCA₃-(3S)-3-hydroxyoctanoic acid-Gi1/β1/γ2
14.29	Single	8JPS	CCL7	8JPS-ACKR1-CCL7
14.29	Single	8JRV	Glucagon	8JRV-Glucagon-Glucagon-Arrestin2
14.29	Consensus	p2y1_off	Orthosteric Ligand	4XNW-P2Y₁-MRS2500
12.50	Single	4O9R	Cyclopamine	4O9R-SMO-Cyclopamine
12.50	Single	6LI0	C17	6LI0-GPR52-C17
12.50	Single	7VDH	C48/80	7VDH-MRGPRX2-C48/80-Gi1/β1/γ2
12.50	Single	8HSC	Fab046	8HSC-GPR20-Fab046-Gi1/β1/γ2
12.50	Single	8U4R	REGN7663-Fab	8U4R-CXCR4-REGN7663-Fab
12.50	Single	9B9Y	7DY	9B9Y-CB₁-7DY
12.50	Single	9E7R	GB88	9E7R-PAR2-GB88-chim(NtGi1L-Gs-CtGq)/β1/γ2
11.11	Single	3V2W	PubChem 51892645	3V2W-S1P₁-PubChem 51892645
11.11	Single	4BWB	Neurotensin	4BWB-NTS₁-Neurotensin
11.11	Single	4QIN	SAG1.5	4QIN-SMO-SAG1.5
11.11	Single	5U09	Taranabant	5U09-CB₁-Taranabant
11.11	Single	6LFO	Interleukin-8	6LFO-CXCR2-Interleukin-8-Gi1/β1/γ2
11.11	Single	6O3C	SAG21k	6O3C-SMO-SAG21k-Cholesterol
11.11	Single	6WWZ	CCL20	6WWZ-CCR6-CCL20-Go/β1/γ2
11.11	Single	7BR3	Elagolix	7BR3-GnRH₁-Elagolix
11.11	Single	7LCJ	Danuglipron	7LCJ-GLP-1-Danuglipron
11.11	Single	7VIH	CBP-307	7VIH-S1P₁-CBP-307-Gi1/β1/γ2
11.11	Single	7VV5	C48/80	7VV5-MRGPRX2-C48/80-Gi1/β1/γ2
11.11	Single	7WF7	S1P	7WF7-S1P₁-S1P-Gi1/β1/γ2
11.11	Single	8HMP	C17	8HMP-GPR52-C17-Gs/β1/γ2
11.11	Single	8U4S	REGN7663-Fab	8U4S-CXCR4-REGN7663-Fab
11.11	Single	8U4T	REGN7663-Fab	8U4T-CXCR4-REGN7663-Fab
11.11	Single	8XXX	CXCL6	8XXX-CXCR2-CXCL6-Go/β1/γ2
11.11	Single	8YYW	Alpha-ketoglutarate	8YYW-Oxoglutarate-α-ketoglutarate-α-ketoglutarate-chim(Gi1-CtGq)/β1/γ2
11.11	Consensus	ccr6_on	Orthosteric Ligand	6WWZ-CCR6-CCL20-Go/β1/γ2
11.11	Consensus	ccr6_on_gp	Orthosteric Ligand	6WWZ-CCR6-CCL20-Go/β1/γ2
11.11	Consensus	cxcr1_on	Orthosteric Ligand	8IC0-CXCR1-Interleukin-8-Gi1/β1/γ2
11.11	Consensus	gnrh1_off	Orthosteric Ligand	7BR3-GnRH₁-Elagolix
11.11	Consensus	p2y1_on	Orthosteric Ligand	7XXH-P2Y₁-2MeSADP-chim(NtGi1-G11)/β1/γ2
11.11	Consensus	s1p1_off	Orthosteric Ligand	3V2W-S1P₁-PubChem 51892645
10.00	Single	3V2Y	PubChem 51892645	3V2Y-S1P₁-PubChem 51892645
10.00	Single	6XBL	SAG	6XBL-SMO-SAG-Cholesterol-Gi1/β1/γ2
10.00	Single	7C2E	PubChem 149050799	7C2E-GLP-1-PubChem 149050799-Gs/β1/γ2
10.00	Single	7UTZ	DPPC	7UTZ-TSH-TR1402-DPPC-Gs/β1/γ2
10.00	Single	7VV6	C48/80	7VV6-MRGPRX2-C48/80
10.00	Single	7XXH	2MeSADP	7XXH-P2Y₁-2MeSADP-chim(NtGi1-G11)/β1/γ2
10.00	Single	7ZI0	SAG	7ZI0-SMO-SAG-Cholesterol
10.00	Single	8H4L	Doconexent	8H4L-FFA4-Doconexent-chim(NtGi1-Gs-CtGq)/β1/γ2
10.00	Single	9BA0	A1AKN	9BA0-CB₁-A1AKN
10.00	Single	9K0K	UTP	9K0K-P2Y₄-UTP-chim(NtGi1-Gs-CtGq)/β1/γ2
10.00	Single	9K0X	ATP	9K0X-P2Y₂-ATP-chim(NtGi1-Gs-CtGq)/β1/γ2
10.00	Single	9K20	ATP	9K20-P2Y₂-ATP-chim(NtGi1-Go)/β1/γ2
10.00	Single	9M2F	Neuropeptide FF	9M2F-NPFF1-Neuropeptide FF-Gi1/β1/γ2
10.00	Consensus	cb1_off	Orthosteric Ligand	5U09-CB₁-Taranabant 5TGZ-CB₁-AM6538
10.00	Consensus	cxcr2_on	Orthosteric Ligand	6LFM-CXCR2-Interleukin-8-Gi1/β1/γ2
10.00	Consensus	grh_off	Orthosteric Ligand	gnrh1_off
10.00	Consensus	nucleotide_off	Orthosteric Ligand	adenosine_off p2y_off
10.00	Consensus	p2y1_on_gp	Orthosteric Ligand	7XXH-P2Y₁-2MeSADP-chim(NtGi1-G11)/β1/γ2
9.09	Single	4QIM	ANTA XV	4QIM-SMO-ANTA XV
9.09	Single	5T04	Neurotensin	5T04-NTS₁-Neurotensin
9.09	Single	5TGZ	AM6538	5TGZ-CB₁-AM6538
9.09	Single	6D27	CAY10471	6D27-DP₂-CAY10471
9.09	Single	6X1A	Danuglipron	6X1A-GLP-1-Danuglipron-Gs/β1/γ2
9.09	Single	6XBM	5LWE	6XBM-SMO-5LWE-Gi1/β1/γ2
9.09	Single	6Z4V	NTS8-13	6Z4V-NTS₁-NTS8-13
9.09	Single	7FIH	Org43553	7FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/β1/γ2
9.09	Single	7LCI	Danuglipron	7LCI-GLP-1-Danuglipron-Gs/β1/γ2
9.09	Single	7LCK	Danuglipron	7LCK-GLP-1-Danuglipron
9.09	Single	7S15	PubChem 134611223	7S15-GLP-1-PubChem 134611223
9.09	Single	7SK8	CXCL12	7SK8-ACKR3-CXCL12-CCX662
9.09	Single	7VIE	S1P	7VIE-S1P₁-S1P-Gi1/β1/γ2
9.09	Single	7VIF	S-FTY720-P	7VIF-S1P₁-S-FTY720-P-Gi1/β1/γ2
9.09	Single	7YU4	ONO-0740556	7YU4-LPA₁-ONO-0740556
9.09	Single	7YXA	ONO-5430608	7YXA-S1P₅-ONO-5430608
9.09	Single	8IC0	Interleukin-8	8IC0-CXCR1-Interleukin-8-Gi1/β1/γ2
9.09	Single	9IVG	GLP-1 (Truncated)	9IVG-GLP-1-GLP-1 (Truncated)-chim(NtGi1-Gs)/β1/γ2
9.09	Consensus	cxcr1_on_gp	Orthosteric Ligand	8IC0-CXCR1-Interleukin-8-Gi1/β1/γ2
9.09	Consensus	lipid_off	Orthosteric Ligand	cannabinoid_off paf_off lpl_off prostanoid_off leukotriene_off
9.09	Consensus	nucleotide_offon	Orthosteric Ligand	nucleotide_off nucleotide_on
9.09	Consensus	nucleotide_offon_gp	Orthosteric Ligand	nucleotide_on_gp nucleotide_off
8.33	Single	4JKV	Taladegib	4JKV-SMO-Taladegib
8.33	Single	5C1M	BU72	5C1M-μ-BU72
8.33	Single	6LFM	Interleukin-8	6LFM-CXCR2-Interleukin-8-Gi1/β1/γ2
8.33	Single	6XBK	Cholesterol	6XBK-SMO-Cholesterol-Gi1/β1/γ2
8.33	Single	7BB7	AVP	7BB7-V₂-AVP-Gs/β1/γ2
8.33	Single	7C4S	S1P	7C4S-S1P₃-S1P
8.33	Single	7EO2	FTY720-P	7EO2-S1P₁-FTY720-P-Gi1/β1/γ2
8.33	Single	7TD3	S1P	7TD3-S1P₁-S1P-Gi1/β1/γ2
8.33	Single	7YU3	ONO-0740556	7YU3-LPA₁-ONO-0740556-Gi1/β1/γ2
8.33	Single	7YU6	ONO-0740556	7YU6-LPA₁-ONO-0740556-Gi1/β1/γ2
8.33	Single	8ID4	Linoleic acid	8ID4-FFA4-Linoleic acid-Gi1/β1/γ2
8.33	Single	8YIC	SAR247799	8YIC-S1P₁-SAR247799-Gi1/β1/γ2
8.33	Single	8ZPT	PrRP20	8ZPT-PrRP-PrRP20-chim(NtGi1-Gs-CtGq)/β1/γ2
8.33	Single	8ZYT	Neurotensin peptide 8-13	8ZYT-NTS₁-Neurotensin peptide 8-13-SBI-553-Arrestin2
8.33	Single	9B9Z	A1AKO	9B9Z-CB₁-A1AKO
8.33	Single	9ERX	D9-THC analog	9ERX-CB₁-D9-THC analog-Gi1/β1/γ2
8.33	Consensus	cxcr2_on_gp	Orthosteric Ligand	6LFM-CXCR2-Interleukin-8-Gi1/β1/γ2
8.33	Consensus	lpa1_on	Orthosteric Ligand	7TD1-LPA₁-LPA-Gi1/β1/γ2 7YU3-LPA₁-ONO-0740556-Gi1/β1/γ2
8.33	Consensus	lpa1_on_gp	Orthosteric Ligand	7TD1-LPA₁-LPA-Gi1/β1/γ2 7YU3-LPA₁-ONO-0740556-Gi1/β1/γ2
8.33	Consensus	s1p5_off	Orthosteric Ligand	7YXA-S1P₅-ONO-5430608
8.33	Consensus	s1p_off	Orthosteric Ligand	s1p1_off s1p5_off
7.69	Single	3ZEV	Neurotensin	3ZEV-NTS₁-Neurotensin
7.69	Single	4BV0	Neurotensin	4BV0-NTS₁-Neurotensin
7.69	Single	4Z34	ONO-9780307	4Z34-LPA₁-ONO-9780307
7.69	Single	5V56	TC114	5V56-SMO-TC114
7.69	Single	5V57	TC114	5V57-SMO-TC114
7.69	Single	6OS1	TRV026	6OS1-AT₁-TRV026
7.69	Single	7EW1	Siponimod	7EW1-S1P₅-Siponimod-Gi1/β1/γ2
7.69	Single	7EW3	S1P	7EW3-S1P₃-S1P-Gi1/β1/γ2
7.69	Single	7F1T	MIP-1a	7F1T-CCR5-MIP-1a
7.69	Single	7F58	THIQ	7F58-MC₄-THIQ-Gs/β1/γ2
7.69	Single	7L0P	Neurotensin	7L0P-NTS₁-Neurotensin-Gi1/β1/γ1
7.69	Single	7L0Q	Neurotensin	7L0Q-NTS₁-Neurotensin-Gi1/β1/γ1
7.69	Single	7R0C	AVP	7R0C-V₂-AVP-Arrestin2
7.69	Single	7SK7	CXCL12	7SK7-ACKR3-CXCL12-CCX662
7.69	Single	7T9N	DPPC	7T9N-TSH-M22 Fab-DPPC-Gs/β1/γ2
7.69	Single	7TD1	LPA	7TD1-LPA₁-LPA-Gi1/β1/γ2
7.69	Single	7VIG	CBP-307	7VIG-S1P₁-CBP-307-Gi1/β1/γ2
7.69	Single	7YU5	ONO-0740556	7YU5-LPA₁-ONO-0740556-Gi1/β1/γ2
7.69	Single	7YU7	ONO-0740556	7YU7-LPA₁-ONO-0740556-Gi1/β1/γ2
7.69	Single	8E0G	BU72	8E0G-μ-BU72
7.69	Single	8FMZ	Neurotensin/Neuromedin-N	8FMZ-NTS₁-Neurotensin/Neuromedin-N-chim(NtGi2L-Gs-CtGq)/β1/γ2
7.69	Single	8FN1	Neurotensin/Neuromedin-N	8FN1-NTS₁-Neurotensin/Neuromedin-N-chim(NtGi1-Go)/β1/γ2
7.69	Single	8HQC	C5a anaphylatoxin	8HQC-C5a₁-C5a anaphylatoxin-Go/β1/γ2
7.69	Single	8I2G	Compound 716340	8I2G-FSH-Glycoprotein hormones α chain-Compound 716340-Gs/β1/γ2
7.69	Single	8ID3	9-Hydroxystearic acid	8ID3-FFA4-9-Hydroxystearic acid-Gi1/β1/γ2
7.69	Single	8ID6	Oleic acid	8ID6-FFA4-Oleic acid-Gi1/β1/γ2
7.69	Single	8JBG	Neurokinin-B	8JBG-NK₃-Neurokinin-B-chim(NtGi1-Gs-CtGq)/β1/γ2
7.69	Single	8JZP	C5A anaphylatoxin	8JZP-C5a₁-C5A anaphylatoxin-Go/β1/γ2
7.69	Single	8WJX	ADP	8WJX-P2Y₁-ADP-chim(Gs-CtGq)/β1/γ2
7.69	Single	8XX7	CXCL5	8XX7-CXCR2-CXCL5-Go/β1/γ2
7.69	Single	9AST	Lymphotactin	9AST-XCR1-Lymphotactin-Gi1/β1/γ2
7.69	Single	9IZG	NKP	9IZG-LPA₁-NKP-chim(NtGi1-Gs-CtGq)/β1/γ2
7.69	Consensus	class-a_off	Orthosteric Ligand	sensory_off alicarboxylic_off amine_off lipid_off nucleotide_off peptide_off protein_off
7.69	Consensus	gi_lpa	Orthosteric Ligand	7TD1-LPA₁-LPA-Gi1/β1/γ2 7YU3-LPA₁-ONO-0740556-Gi1/β1/γ2
7.69	Consensus	lpa_on	Orthosteric Ligand	lpa1_on
7.69	Consensus	lpa_on_gp	Orthosteric Ligand	lpa1_on_gp
7.69	Consensus	motilin_on	Orthosteric Ligand	8IBU-Motilin-Erythromycin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
7.69	Consensus	neurotensin_on	Orthosteric Ligand	nts1_on
7.69	Consensus	nts1_on	Orthosteric Ligand	6OSA-NTS₁-JMV449-Gi1/β1/γ2 7L0S-NTS₁-Neurotensin-Gi1/β1/γ1
7.69	Consensus	protein_off	Orthosteric Ligand	chemokine_off grh_off
7.69	Consensus	s1p5_on	Orthosteric Ligand	7EW1-S1P₅-Siponimod-Gi1/β1/γ2
7.69	Consensus	s1p5_on_gp	Orthosteric Ligand	7EW1-S1P₅-Siponimod-Gi1/β1/γ2
7.14	Single	4GRV	Neurotensin-(8-13)	4GRV-NTS₁-Neurotensin-(8-13)
7.14	Single	4XEE	Neurotensin	4XEE-NTS₁-Neurotensin
7.14	Single	4XES	Neurotensin	4XES-NTS₁-Neurotensin
7.14	Single	6KPG	AM841	6KPG-CB₁-AM841-Gi1/β1/γ2
7.14	Single	6OS0	Angiotensinogen	6OS0-AT₁-Angiotensinogen
7.14	Single	6OS2	TRV026	6OS2-AT₁-TRV026
7.14	Single	6OSA	JMV449	6OSA-NTS₁-JMV449-Gi1/β1/γ2
7.14	Single	6XOX	Orforglipron	6XOX-GLP-1-Orforglipron-chim(NtGi1-Gs)/β1/γ2
7.14	Single	6YVR	NTS8-13	6YVR-NTS₁-NTS8-13
7.14	Single	7EVY	Siponimod	7EVY-S1P₁-Siponimod-Gi1/β1/γ2
7.14	Single	7EW2	Fingolimod	7EW2-S1P₃-Fingolimod-Gi1/β1/γ2
7.14	Single	7L0S	Neurotensin	7L0S-NTS₁-Neurotensin-Gi1/β1/γ1
7.14	Single	7W0N	Elabela	7W0N-Apelin-Elabela-Gi1/β1/γ2
7.14	Single	7XW5	ML109	7XW5-TSH-TSH-ML109-Gs/β1/γ2
7.14	Single	8IBU	Erythromycin-A	8IBU-Motilin-Erythromycin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
7.14	Single	8JPB	Neurotensin-(8-13)	8JPB-NTS₁-Neurotensin-(8-13)-SBI-553; GDP; Mg-Gq; GRK2
7.14	Single	8JPC	Neurotensin-(8-13)	8JPC-NTS₁-Neurotensin-(8-13)-SBI-553; GDP; Mg-Gq; GRK2
7.14	Single	8T3Q	Docosa-4,7,10,13,16,19-Hexaenoic acid	8T3Q-FFA4-Docosa-4,7,10,13,16,19-Hexaenoic acid-chim(NtGi2L-Gs-CtGq)/β1/γ2
7.14	Single	8U26	Protachykinin-1	8U26-NK₁-Protachykinin-1-Gs/β1/γ2
7.14	Single	8XQJ	JN241	8XQJ-Apelin-JN241
7.14	Single	8XWA	CXCL1	8XWA-CXCR2-CXCL1
7.14	Single	8XWM	CXCL6	8XWM-CXCR2-CXCL6
7.14	Single	8XWS	CXCL5	8XWS-CXCR2-CXCL5
7.14	Single	8XX3	CXCL3	8XX3-CXCR2-CXCL3-Go/β1/γ2
7.14	Single	9IZH	LPA	9IZH-LPA₁-LPA-chim(NtGi2-G13)/β1/γ2
7.14	Consensus	cannabinoid_off	Orthosteric Ligand	cb2_off cb1_off
7.14	Consensus	ccr8_on	Orthosteric Ligand	8KFX-CCR8-LMD-009-Gi1/β1/γ2 8KFY-CCR8-ZK-756326-Gi1/β1/γ2 8U1U-CCR8-CCL1-Gi1/β1/γ2
7.14	Consensus	cxcr_on	Orthosteric Ligand	cxcr3_on cxcr4_on cxcr1_on cxcr2_on
7.14	Consensus	gi_lipid	Orthosteric Ligand	gi_cannabinoid gi_ffa gi_leukotriene gi_lpa gi_s1p
7.14	Consensus	gi_neurotensin	Orthosteric Ligand	6OSA-NTS₁-JMV449-Gi1/β1/γ2 7L0S-NTS₁-Neurotensin-Gi1/β1/γ1
7.14	Consensus	lipid_offon	Orthosteric Ligand	lipid_off lipid_on
7.14	Consensus	lipid_offon_gp	Orthosteric Ligand	lipid_on_gp lipid_off
7.14	Consensus	lpa1_off	Orthosteric Ligand	4Z36-LPA₁-ONO-3080573 4Z35-LPA₁-ONO-9910539 4Z34-LPA₁-ONO-9780307
7.14	Consensus	lpa_off	Orthosteric Ligand	lpa1_off
7.14	Consensus	lpl_off	Orthosteric Ligand	s1p_off lpa_off
7.14	Consensus	mop_on	Orthosteric Ligand	8F7R-μ-Endomorphin-Gi1/β1/γ2 8EF5-μ-Fentanyl-Gi1/β1/γ2 7SCG-μ-FH210-Gi1/β1/γ2 7T2H-μ-Lofentanil-Gi1/β1/γ2 7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2 8EF6-μ-Morphine-Gi1/β1/γ2 8EFB-μ-Oliceridine-Gi1/β1/γ2 7U2L-μ-PubChem 163201242-Gi1/β1/γ2 8EFO-μ-PZM21-Gi1/β1/γ2 8EFL-μ-SR17018-Gi1/β1/γ2 8F7Q-μ-β-Endorphin-Gi1/β1/γ2 7U2K-μ-C6-guano-Gi1/β1/γ2 8EFQ-μ-Damgo-Gi1/β1/γ2
7.14	Consensus	mop_on_gp	Orthosteric Ligand	8F7R-μ-Endomorphin-Gi1/β1/γ2 8EF5-μ-Fentanyl-Gi1/β1/γ2 7SCG-μ-FH210-Gi1/β1/γ2 7T2H-μ-Lofentanil-Gi1/β1/γ2 7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2 8EF6-μ-Morphine-Gi1/β1/γ2 8EFB-μ-Oliceridine-Gi1/β1/γ2 7U2L-μ-PubChem 163201242-Gi1/β1/γ2 8EFO-μ-PZM21-Gi1/β1/γ2 8EFL-μ-SR17018-Gi1/β1/γ2 8F7Q-μ-β-Endorphin-Gi1/β1/γ2 7U2K-μ-C6-guano-Gi1/β1/γ2 8EFQ-μ-Damgo-Gi1/β1/γ2
7.14	Consensus	motilin_on_gp	Orthosteric Ligand	8IBU-Motilin-Erythromycin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
7.14	Consensus	neurotensin_on_gp	Orthosteric Ligand	nts1_on_gp
7.14	Consensus	nts1_on_gp	Orthosteric Ligand	6OSA-NTS₁-JMV449-Gi1/β1/γ2 7L0S-NTS₁-Neurotensin-Gi1/β1/γ1
7.14	Consensus	s1p1_on	Orthosteric Ligand	7VIE-S1P₁-S1P-Gi1/β1/γ2 7VIF-S1P₁-S-FTY720-P-Gi1/β1/γ2 7VIG-S1P₁-CBP-307-Gi1/β1/γ2 7EVY-S1P₁-Siponimod-Gi1/β1/γ2 7EVZ-S1P₁-Cenerimod-Gi1/β1/γ2 7EW0-S1P₁-Ozanimod-Gi1/β1/γ2 7EW7-S1P₁-SEW2871-Gi1/β1/γ2
7.14	Consensus	s1p1_on_gp	Orthosteric Ligand	7VIE-S1P₁-S1P-Gi1/β1/γ2 7VIF-S1P₁-S-FTY720-P-Gi1/β1/γ2 7VIG-S1P₁-CBP-307-Gi1/β1/γ2 7EVY-S1P₁-Siponimod-Gi1/β1/γ2 7EVZ-S1P₁-Cenerimod-Gi1/β1/γ2 7EW0-S1P₁-Ozanimod-Gi1/β1/γ2 7EW7-S1P₁-SEW2871-Gi1/β1/γ2
7.14	Consensus	s1p3_on	Orthosteric Ligand	7EW3-S1P₃-S1P-Gi1/β1/γ2 7EW4-S1P₃-CYM5541-Gi1/β1/γ2 7EW2-S1P₃-Fingolimod-Gi1/β1/γ2
6.67	Single	4BUO	Neurotensin	4BUO-NTS₁-Neurotensin
6.67	Single	4RWS	vMIP-II	4RWS-CXCR4-vMIP-II
6.67	Single	4Z35	ONO-9910539	4Z35-LPA₁-ONO-9910539
6.67	Single	6M1H	Maxadilan	6M1H-PAC₁-Maxadilan-Gs/β1/γ2
6.67	Single	6UP7	Neurotensin	6UP7-NTS₁-Neurotensin-Arrestin2
6.67	Single	7EVZ	Cenerimod	7EVZ-S1P₁-Cenerimod-Gi1/β1/γ2
6.67	Single	7EW0	Ozanimod	7EW0-S1P₁-Ozanimod-Gi1/β1/γ2
6.67	Single	7LLL	Exendin-4	7LLL-GLP-1-Exendin-4-Gs/β1/γ2
6.67	Single	7P00	Substance-P	7P00-NK₁-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
6.67	Single	7VVN	PTH	7VVN-PTH1-PTH-Gs/β1/γ2
6.67	Single	7X8R	BOC5	7X8R-GLP-1-BOC5-Gs/β1/γ2
6.67	Single	7YU8	ONO-0740556	7YU8-LPA₁-ONO-0740556-Gi1/β1/γ2
6.67	Single	8FN0	Neurotensin/Neuromedin-N	8FN0-NTS₁-Neurotensin/Neuromedin-N-SBI-553-chim(NtGi1-Go)/β1/γ2
6.67	Single	8IYS	TUG-891	8IYS-FFA4-TUG-891-GDP-chim(NtGi1L-Gq)/β1/γ2
6.67	Single	8JPF	Neurotensin	8JPF-NTS₁-Neurotensin-SBI-553
6.67	Single	8K4O	CXCL1	8K4O-KSHV-CXCL1-Gi1/β1/γ1
6.67	Single	8XVU	CXCL2	8XVU-CXCR2-CXCL2
6.67	Single	8XWF	CXCL3	8XWF-CXCR2-CXCL3
6.67	Single	8XWV	CXCL1	8XWV-CXCR2-CXCL1-Go/β1/γ2
6.67	Single	8XXH	CXCL2	8XXH-CXCR2-CXCL2-Go/β1/γ2
6.67	Single	8ZX4	Lysophosphatidylinositol	8ZX4-GPR55-Lysophosphatidylinositol-chim(NtGi1-G13)/β1/γ2
6.67	Single	9C0K	Exendin-4	9C0K-GLP-1-Exendin-4-Gs/β1/γ2
6.67	Single	9GE3	Lysophosphatidylinositol	9GE3-GPR55-Lysophosphatidylinositol-chim(NtGi1-G13)/β1/γ2
6.67	Single	9IZF	NKP	9IZF-LPA₁-NKP-Gi1/β1/γ2
6.67	Consensus	class-a_on	Orthosteric Ligand	sensory_on alicarboxylic_on amine_on lipid_on nucleotide_on peptide_on protein_on
6.67	Consensus	gi_s1p	Orthosteric Ligand	7VIE-S1P₁-S1P-Gi1/β1/γ2 7EW3-S1P₃-S1P-Gi1/β1/γ2 7EVY-S1P₁-Siponimod-Gi1/β1/γ2 7EW1-S1P₅-Siponimod-Gi1/β1/γ2 7VIF-S1P₁-S-FTY720-P-Gi1/β1/γ2 7VIG-S1P₁-CBP-307-Gi1/β1/γ2 7EVZ-S1P₁-Cenerimod-Gi1/β1/γ2 7EW4-S1P₃-CYM5541-Gi1/β1/γ2 7EW2-S1P₃-Fingolimod-Gi1/β1/γ2 7EW0-S1P₁-Ozanimod-Gi1/β1/γ2 7EW7-S1P₁-SEW2871-Gi1/β1/γ2
6.67	Consensus	nk1_on	Orthosteric Ligand	7P00-NK₁-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
6.67	Consensus	nk1_on_gp	Orthosteric Ligand	7P00-NK₁-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
6.25	Single	5VBL	Apelin mimetic peptide agonist	5VBL-Apelin-Apelin mimetic peptide agonist
6.25	Single	6KNM	JN241-9	6KNM-Apelin-JN241-9
6.25	Single	6OS9	JMV449	6OS9-NTS₁-JMV449-Gi1/β1/γ2
6.25	Single	7AUE	Setmelanotide	7AUE-MC₄-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2
6.25	Single	7RKF	Fractalkine	7RKF-US28-Fractalkine-GDP-chim(NtGi1-G11)/β1/γ2
6.25	Single	7RKN	Fractalkine	7RKN-US28-Fractalkine-Gi1/β1/γ2
6.25	Single	7RMG	Substance-P	7RMG-NK₁-Substance-P-chim(Gs-CtGq)/β1/γ2
6.25	Single	7RMH	Substance-P	7RMH-NK₁-Substance-P-Gs/β1/γ2
6.25	Single	7X8S	WB4-24	7X8S-GLP-1-WB4-24-Gs/β1/γ2
6.25	Single	7XBX	CX3CL1	7XBX-CX3CR1-CX3CL1-Gi1/β1/γ2
6.25	Single	8H4I	Doconexent	8H4I-FFA4-Doconexent-chim(NtGi1-Gs)/β1/γ2
6.25	Single	8JBF	Senktide	8JBF-NK₃-Senktide-chim(NtGi1-Gs-CtGq)/β1/γ2
6.25	Single	8QJ2	pN162	8QJ2-MC₄-pN162-Gs
6.25	Single	8XQJ	JN241	8XQJ-Apelin-JN241
6.25	Single	8XX6	CXCL8	8XX6-CXCR2-CXCL8-Go/β1/γ2
6.25	Consensus	cxcr3_on	Orthosteric Ligand	8HNK-CXCR3-CXCL11-Gi1/β1/γ2 8HNL-CXCR3-PS372424-Gi1/β1/γ2
6.25	Consensus	cxcr4_off	Orthosteric Ligand	4RWS-CXCR4-vMIP-II 3OE0-CXCR4-CVX15 3OE6-CXCR4-IT1t
6.25	Consensus	cxcr_on_gp	Orthosteric Ligand	cxcr3_on_gp cxcr4_on_gp cxcr1_on_gp cxcr2_on_gp
6.25	Consensus	s1p_on	Orthosteric Ligand	s1p1_on s1p3_on s1p5_on
6.25	Consensus	s1p_on_gp	Orthosteric Ligand	s1p1_on_gp s1p3_on_gp s1p5_on_gp
5.88	Single	4XT1	Fractalkine	4XT1-US28-Fractalkine
5.88	Single	6X19	CHU-128	6X19-GLP-1-CHU-128-Gs/β1/γ2
5.88	Single	7F54	Afamelanotide	7F54-MC₄-Afamelanotide-Gs/β1/γ2
5.88	Single	7L0R	Neurotensin	7L0R-NTS₁-Neurotensin-Gi1/β1/γ1
5.88	Single	7RTB	Peptide-19	7RTB-GLP-1-Peptide-19-Gs/β1/γ2
5.88	Single	7TD4	Siponimod	7TD4-S1P₁-Siponimod-Gi1/β1/γ2
5.88	Single	7VLA	CCL15(27-92)	7VLA-CCR1-CCL15(27-92)-Gi1/β1/γ2
5.88	Single	7W0P	Elabela	7W0P-Apelin-Elabela-Gi1/β1/γ2
5.88	Single	7W2Z	Ghrelin	7W2Z-Ghrelin-Ghrelin-Go/β1/γ2
5.88	Single	8JIQ	Peptide-15	8JIQ-Glucagon-Peptide-15-Gs/β1/γ2
5.88	Single	8K3Z	CXCL12	8K3Z-CXCR4-CXCL12-Gi1/β1/γ1
5.88	Single	8U4O	CXCL12	8U4O-CXCR4-CXCL12-Gi1/β1/γ2
5.88	Single	8WZ2	Orexigenic Neuropeptide QRFP	8WZ2-QRFP-Orexigenic Neuropeptide QRFP-chim(NtGi1L-Gs-CtGq)/β1/γ2
5.88	Single	8XFT	R-spondin-2	8XFT-LGR4-R-spondin-2-ZNRF3
5.88	Single	8XGM	Chemerin	8XGM-CML2-Chemerin-Gi1/β1/γ2
5.88	Single	8XWN	CXCL8	8XWN-CXCR2-CXCL8
5.88	Single	8Y69	R-spondin-2	8Y69-LGR4-R-spondin-2-ZNRF3
5.88	Single	8YWF	Retatrutide	8YWF-GLP-1-Retatrutide-chim(NtGi1-Gs)/β1/γ2
5.88	Single	9BUE	Cagrilintide	9BUE-CT-Cagrilintide-Gs/β1/γ2
5.88	Single	9L3Y	Retinoic acid receptor responder protein 2	9L3Y-CML2-Retinoic acid receptor responder protein 2-Gi1/β1/γ2
5.88	Consensus	ccr1_on	Orthosteric Ligand	7VLA-CCR1-CCL15(27-92)-Gi1/β1/γ2
5.88	Consensus	ccr1_on_gp	Orthosteric Ligand	7VLA-CCR1-CCL15(27-92)-Gi1/β1/γ2
5.88	Consensus	chemokine_on	Orthosteric Ligand	ccr_on cxcr_on
5.88	Consensus	class-a_on_gp	Orthosteric Ligand	sensory_on_gp alicarboxylic_on_gp amine_on_gp lipid_on_gp nucleotide_on_gp peptide_on_gp protein_on_gp
5.88	Consensus	cxcr4_on	Orthosteric Ligand	8K3Z-CXCR4-CXCL12-Gi1/β1/γ1
5.88	Consensus	gi_opioid	Orthosteric Ligand	8F7R-μ-Endomorphin-Gi1/β1/γ2 8EF5-μ-Fentanyl-Gi1/β1/γ2 7SCG-μ-FH210-Gi1/β1/γ2 7T2H-μ-Lofentanil-Gi1/β1/γ2 7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2 8DZP-κ-momSalB-Gi1/β1/γ2 8EF6-μ-Morphine-Gi1/β1/γ2 8F7X-NOP-Nociceptin-Gi1/β1/γ2 8EFB-μ-Oliceridine-Gi1/β1/γ2 7U2L-μ-PubChem 163201242-Gi1/β1/γ2 8EFO-μ-PZM21-Gi1/β1/γ2 8EFL-μ-SR17018-Gi1/β1/γ2 8F7Q-μ-β-Endorphin-Gi1/β1/γ2 7U2K-μ-C6-guano-Gi1/β1/γ2 8EFQ-μ-Damgo-Gi1/β1/γ2 8F7S-δ-Deltorphin-Gi1/β1/γ2 8F7W-κ-Dynorphin-Gi1/β1/γ2
5.88	Consensus	lpl_on	Orthosteric Ligand	s1p_on lpa_on
5.88	Consensus	lpl_on_gp	Orthosteric Ligand	s1p_on_gp lpa_on_gp
5.88	Consensus	mc4_on	Orthosteric Ligand	7AUE-MC₄-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2 7F58-MC₄-THIQ-Gs/β1/γ2 7F54-MC₄-Afamelanotide-Gs/β1/γ2 7F53-MC₄-α-MSH-Gs/β1/γ2 7F55-MC₄-Bremelanotide-Gs/β1/γ2
5.88	Consensus	nk3_on	Orthosteric Ligand	8JBF-NK₃-Senktide-chim(NtGi1-Gs-CtGq)/β1/γ2
5.88	Consensus	nk3_on_gp	Orthosteric Ligand	8JBF-NK₃-Senktide-chim(NtGi1-Gs-CtGq)/β1/γ2
5.88	Consensus	p2y_on	Orthosteric Ligand	p2y1_on p2y10_on p2y12_on
5.56	Single	6DO1	Angiotensin-like peptide S1I8	6DO1-AT₁-Angiotensin-like peptide S1I8
5.56	Single	6WHC	Glu16 analog of GCG	6WHC-Glucagon-Glu16 analog of GCG-Gs/β1/γ2
5.56	Single	7C6A	(Sar1,Ile8)-Angiotensin II	7C6A-AT₂-(Sar1,Ile8)-Angiotensin II
5.56	Single	7E14	Orforglipron	7E14-GLP-1-Orforglipron-PubChem 156022738-Gs/β1/γ2
5.56	Single	7F1Q	MIP-1a	7F1Q-CCR5-MIP-1a-Gi1/β1/γ2
5.56	Single	7PIV	Setmelanotide	7PIV-MC₄-Setmelanotide-Gs/β1/γ2
5.56	Single	7RKM	Fractalkine	7RKM-US28-Fractalkine-Gi1/β1/γ2
5.56	Single	7RMI	Substance-P	7RMI-NK₁-Substance-P-chim(Gs-CtGq)/β1/γ2
5.56	Single	7SK5	CXCL12	7SK5-ACKR3-CXCL12
5.56	Single	7TRY	Urocortin	7TRY-CRF₂-Urocortin-chim(NtGi1-G11)/β1/γ2
5.56	Single	7VBI	Non-Acylated Tirzepatide	7VBI-GLP-1-Non-Acylated Tirzepatide-Gs/β1/γ2
5.56	Single	8F7Q	Beta-Endorphin	8F7Q-μ-β-Endorphin-Gi1/β1/γ2
5.56	Single	8IBV	Motilin	8IBV-Motilin-Motilin-chim(NtGi1-Gs-CtGq)/β1/γ2
5.56	Single	8IOC	Gamma-MSH	8IOC-MC₃-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
5.56	Single	8JZZ	C5a-desArg	8JZZ-C5a₁-C5a-desArg-Go/β1/γ2
5.56	Single	8Z7J	Agonistic antibody	8Z7J-Apelin-Agonistic antibody-Gi1/β1/γ2
5.56	Consensus	ccr8_on_gp	Orthosteric Ligand	8KFX-CCR8-LMD-009-Gi1/β1/γ2 8KFY-CCR8-ZK-756326-Gi1/β1/γ2 8U1U-CCR8-CCL1-Gi1/β1/γ2
5.56	Consensus	compl-peptide_on	Orthosteric Ligand	c5a1_on c3a_on
5.56	Consensus	mc4_on_gp	Orthosteric Ligand	7AUE-MC₄-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2 7F58-MC₄-THIQ-Gs/β1/γ2 7F54-MC₄-Afamelanotide-Gs/β1/γ2 7F53-MC₄-α-MSH-Gs/β1/γ2 7F55-MC₄-Bremelanotide-Gs/β1/γ2
5.56	Consensus	s1p3_on_gp	Orthosteric Ligand	7EW3-S1P₃-S1P-Gi1/β1/γ2 7EW4-S1P₃-CYM5541-Gi1/β1/γ2 7EW2-S1P₃-Fingolimod-Gi1/β1/γ2
5.56	Consensus	tachykinin_on_gp	Orthosteric Ligand	nk1_on_gp nk2_on_gp nk3_on_gp
5.26	Single	3OE0	CVX15	3OE0-CXCR4-CVX15
5.26	Single	6LW5	WKYMVm	6LW5-FPR2-ALX-WKYMVm
5.26	Single	6MEO	Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4	6MEO-CCR5-Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4
5.26	Single	6UUN	Adrenomedullin	6UUN-CT Like (AM1)-Adrenomedullin-Gs/β1/γ2; RAMP2
5.26	Single	7O7F	6P4-CCL5	7O7F-CCR5-6P4-CCL5-Gi1/β1/γ1
5.26	Single	7RYC	Oxytocin	7RYC-OT-Oxytocin-chim(NtGi2L-Gs-CtGq)/β1/γ2
5.26	Single	7TD0	LPA	7TD0-LPA₁-LPA-Gi1/β1/γ2
5.26	Single	7TD2	LPA	7TD2-LPA₁-LPA-Gi1/β1/γ2
5.26	Single	7XA3	CCL2	7XA3-CCR2-CCL2-Gi1/β1/γ2
5.26	Single	8K6N	Pro-neuropeptide-Y	8K6N-Y₂-Pro-neuropeptide-Y-Gi2/β1/γ1
5.26	Single	8WKZ	SBL-MC-31	8WKZ-MC₄-SBL-MC-31
5.26	Single	8WVU	R-spondin-1	8WVU-LGR4-R-spondin-1-RNF43
5.26	Single	8XZH	MM07	8XZH-Apelin-MM07-Gi1/β1/γ2
5.26	Single	8Y69	R-spondin-2	8Y69-LGR4-R-spondin-2-ZNRF3
5.26	Single	9IVM	GLP-1 (Truncated)	9IVM-GLP-1-GLP-1 (Truncated)-LSN3318839-chim(NtGi1-Gs)/β2/γ2
5.26	Single	9K27	PrRP31	9K27-PrRP-PrRP31-chim(NtGi1-Gq)/β1/γ2
5.26	Single	9M1O	Morphine-Modulating Neuropeptide B	9M1O-NPFF2-Morphine-Modulating Neuropeptide B-Gi1/β1/γ2
5.26	Single	9U4W	Gonadoliberin-1	9U4W-GnRH₁-Gonadoliberin-1-chim(NtGi1L-Gs-CtGq)/β1/γ2
5.26	Consensus	angiotensin_on	Orthosteric Ligand	at1_on
5.26	Consensus	at1_on	Orthosteric Ligand	7F6G-AT₁-SAR1-AngII-Gq/β1/γ2
5.26	Consensus	c5a1_on	Orthosteric Ligand	8HK5-C5a₁-Complement C5-Gi1/β1/γ2 7Y66-C5a₁-BM213-Gi1/β1/γ2 7Y67-C5a₁-C089 peptide-Gi1/β1/γ2 7Y64-C5a₁-C5a anaphylatoxin-Gi1/β1/γ2
5.26	Consensus	ccr2_on	Orthosteric Ligand	7XA3-CCR2-CCL2-Gi1/β1/γ2
5.26	Consensus	ccr2_on_gp	Orthosteric Ligand	7XA3-CCR2-CCL2-Gi1/β1/γ2
5.26	Consensus	ccr_on	Orthosteric Ligand	ccr6_on ccr8_on ccr2_on ccr1_on ccr5_on
5.26	Consensus	class-b1_class-b2_cons_on	Orthosteric Ligand	class-b1_on class-b2_on
5.26	Consensus	class-b1_class-b2_cons_on_gp	Orthosteric Ligand	class-b1_on_gp class-b2_on_gp
5.26	Consensus	compl-peptide_on_gp	Orthosteric Ligand	c5a1_on_gp c3a_on_gp
5.26	Consensus	cxcr4_on_gp	Orthosteric Ligand	8K3Z-CXCR4-CXCL12-Gi1/β1/γ1
5.26	Consensus	mc3_on	Orthosteric Ligand	8IOC-MC₃-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
5.26	Consensus	mc3_on_gp	Orthosteric Ligand	8IOC-MC₃-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
5.00	Single	5WB2	CX3CL1.35	5WB2-US28-CX3CL1.35
5.00	Single	6M1I	PACAP	6M1I-PAC₁-PACAP-Gs/β1/γ2
5.00	Single	6MET	Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4	6MET-CCR5-Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4
5.00	Single	6WI9	Secretin	6WI9-Secretin-Secretin-Gs/β1/γ2
5.00	Single	7DW9	AVP	7DW9-V₂-AVP-chim(NtGi1-Gs)/β1/γ2
5.00	Single	7F6G	SAR1-AngII	7F6G-AT₁-SAR1-AngII-Gq/β1/γ2
5.00	Single	7FIM	Tirzepatide	7FIM-GLP-1-Tirzepatide-Gs/β1/γ2
5.00	Single	7FIN	Peptide-20; GGL	7FIN-GIP-Peptide-20; GGL-Gs/β1/γ2
5.00	Single	7TYI	Amylin	7TYI-CT-Amylin-Gs/β1/γ2
5.00	Single	7YON	Peptide-YY(3-36)	7YON-Y₂-Peptide-YY(3-36)-Gi1/β1/γ2
5.00	Single	8H4K	GW9508	8H4K-FFA4-GW9508-chim(NtGi1-Gs-CtGq)/β1/γ2
5.00	Single	8HA0	PTH	8HA0-PTH1-PTH-chim(NtGi1-Gs)/β1/γ2
5.00	Single	8XFP	R-spondin-2	8XFP-LGR4-R-spondin-2-ZNRF3
5.00	Single	8XZJ	WN353	8XZJ-Apelin-WN353-Gi1/β1/γ2
5.00	Single	8YW3	Retatrutide	8YW3-GLP-1-Retatrutide-Gs/β1/γ2
5.00	Single	8YW4	Retatrutide	8YW4-GIP-Retatrutide-chim(NtGi1-Gs)/β1/γ2
5.00	Single	8YW5	Retatrutide	8YW5-Glucagon-Retatrutide-Gs/β1/γ2
5.00	Single	9BLC	Cagrilintide backbone (non-acylated)	9BLC-CT-Cagrilintide backbone (non-acylated)-Gs/β1/γ2
5.00	Single	9BUD	Cagrilintide	9BUD-CT-Cagrilintide-Gs/β1/γ2
5.00	Single	9EBO	GLP-1 (ACPC18)	9EBO-GLP-1-GLP-1 (ACPC18)-Gs/β1/γ2
5.00	Consensus	angiotensin_on_gp	Orthosteric Ligand	at1_on_gp
5.00	Consensus	at1_on_gp	Orthosteric Ligand	7F6G-AT₁-SAR1-AngII-Gq/β1/γ2
5.00	Consensus	c5a1_on_gp	Orthosteric Ligand	8HK5-C5a₁-Complement C5-Gi1/β1/γ2 7Y66-C5a₁-BM213-Gi1/β1/γ2 7Y67-C5a₁-C089 peptide-Gi1/β1/γ2 7Y64-C5a₁-C5a anaphylatoxin-Gi1/β1/γ2
5.00	Consensus	crf2_on	Orthosteric Ligand	7TS0-CRF₂-Urocortin-chim(NtGi1L-Go)/β1/γ2
5.00	Consensus	cxcr3_on_gp	Orthosteric Ligand	8HNK-CXCR3-CXCL11-Gi1/β1/γ2 8HNL-CXCR3-PS372424-Gi1/β1/γ2
5.00	Consensus	gi_class-a	Orthosteric Ligand	gi_peptide gi_sensory gi_alicarboxylic gi_amine gi_lipid gi_nucleotide gi_protein
5.00	Consensus	gq_angiotensin	Orthosteric Ligand	7F6G-AT₁-SAR1-AngII-Gq/β1/γ2
5.00	Consensus	gs_vasop-oxy	Orthosteric Ligand	7DW9-V₂-AVP-chim(NtGi1-Gs)/β1/γ2
5.00	Consensus	p2y_on_gp	Orthosteric Ligand	p2y1_on_gp p2y10_on_gp p2y12_on_gp
5.00	Consensus	protein_offon	Orthosteric Ligand	protein_off protein_on
5.00	Consensus	protein_offon_gp	Orthosteric Ligand	protein_on_gp protein_off
5.00	Consensus	protein_on	Orthosteric Ligand	chemokine_on chemerin_on
5.00	Consensus	tachykinin_on	Orthosteric Ligand	nk1_on nk2_on nk3_on
5.00	Consensus	v2_on	Orthosteric Ligand	7DW9-V₂-AVP-chim(NtGi1-Gs)/β1/γ2
5.00	Consensus	v2_on_gp	Orthosteric Ligand	7DW9-V₂-AVP-chim(NtGi1-Gs)/β1/γ2
5.00	Consensus	vasop-oxy_on	Orthosteric Ligand	v2_on
5.00	Consensus	vasop-oxy_on_gp	Orthosteric Ligand	v2_on_gp
4.76	Single	5YQZ	Glucagon analogue	5YQZ-Glucagon-Glucagon analogue
4.76	Single	6X18	GLP-1	6X18-GLP-1-GLP-1-Gs/β1/γ2
4.76	Single	7F6H	Bradykinin	7F6H-BK₂-Bradykinin-Gq/β1/γ2
4.76	Single	7F6I	Kallidin	7F6I-BK₂-Kallidin-Gq/β1/γ2
4.76	Single	7F9Y	Ghrelin-28	7F9Y-Ghrelin-Ghrelin-28-chim(NtGi1-Gs-CtGq)/β1/γ2
4.76	Single	7LLY	Oxyntomodulin	7LLY-GLP-1-Oxyntomodulin-Gs/β1/γ2
4.76	Single	7P02	Protachykinin-1	7P02-NK₁-Protachykinin-1-chim(NtGi1-Gs)/β1/γ2
4.76	Single	7TYH	Calcitonin-1	7TYH-CT (AMY2)-Calcitonin-1-Gs/β1/γ2; RAMP2
4.76	Single	7TYW	Calcitonin-1	7TYW-CT (AMY1)-Calcitonin-1-Gs/β1/γ2; RAMP1
4.76	Single	7VL9	CCL15(26-92)	7VL9-CCR1-CCL15(26-92)-Gi1/β1/γ2
4.76	Single	7WBJ	PACAP27	7WBJ-VPAC₁-PACAP27-Gs/β1/γ2
4.76	Single	7X9B	Neuropeptide-Y	7X9B-Y₂-Neuropeptide-Y-Gi1/β1/γ2
4.76	Single	7Y35	Abaloparatide	7Y35-PTH1-Abaloparatide-Gs/β1/γ2
4.76	Single	7Y64	C5a anaphylatoxin	7Y64-C5a₁-C5a anaphylatoxin-Gi1/β1/γ2
4.76	Single	8E3Y	PACAP27	8E3Y-VPAC₁-PACAP27-Gs/β1/γ2
4.76	Single	8E3Z	VIP	8E3Z-VPAC₁-VIP-Gs/β1/γ2
4.76	Single	8HCQ	Endothelin-1	8HCQ-ET_A-Endothelin-1-chim(NtGi1-Gs-CtGq)/β1/γ2
4.76	Single	8HK5	Complement C5	8HK5-C5a₁-Complement C5-Gi1/β1/γ2
4.76	Single	8HNK	CXCL11	8HNK-CXCR3-CXCL11-Gi1/β1/γ2
4.76	Single	8IA2	C5a anaphylatoxin	8IA2-C5a₁-C5a anaphylatoxin-Go/β1/γ2
4.76	Single	8XQE	Apelin-13	8XQE-Apelin-Apelin-13-Gi1/β1/γ2
4.76	Single	8XVH	Endothelin-1	8XVH-ET_B-Endothelin-1-chim(Gs-CtGq)/β1/γ2
4.76	Single	8XVI	Endothelin-1	8XVI-ET_A-Endothelin-1-chim(Gs-CtGq)/β1/γ2
4.76	Single	8ZPS	PrRP20	8ZPS-PrRP-PrRP20-chim(NtGi1-Gs-CtGq)/β1/γ2
4.76	Single	9JFY	hNPSF	9JFY-NPFF2-hNPSF-Gi1/β1/γ2
4.76	Consensus	calcitonin_on	Orthosteric Ligand	ctlike_on
4.76	Consensus	ccr_on_gp	Orthosteric Ligand	ccr6_on_gp ccr8_on_gp ccr2_on_gp ccr1_on_gp ccr5_on_gp
4.76	Consensus	chemokine_off	Orthosteric Ligand	ccr_off cxcr_off
4.76	Consensus	chemokine_on_gp	Orthosteric Ligand	ccr_on_gp cxcr_on_gp
4.76	Consensus	cxcr_off	Orthosteric Ligand	cxcr3_off cxcr4_off
4.76	Consensus	eta_on	Orthosteric Ligand	8HCQ-ET_A-Endothelin-1-chim(NtGi1-Gs-CtGq)/β1/γ2
4.76	Consensus	eta_on_gp	Orthosteric Ligand	8HCQ-ET_A-Endothelin-1-chim(NtGi1-Gs-CtGq)/β1/γ2
4.76	Consensus	gi_apelin	Orthosteric Ligand	8XZH-Apelin-MM07-Gi1/β1/γ2 7W0M-Apelin-PubChem 122701908-Gi1/β1/γ2 8XZJ-Apelin-WN353-Gi1/β1/γ2 8XZF-Apelin-WN561-Gi1/β1/γ2 8XZG-Apelin-Apelin-13-Gi1/β1/γ2
4.76	Consensus	gi_chemokine	Orthosteric Ligand	6WWZ-CCR6-CCL20-Go/β1/γ2 8HNK-CXCR3-CXCL11-Gi1/β1/γ2 8K3Z-CXCR4-CXCL12-Gi1/β1/γ1 8IC0-CXCR1-Interleukin-8-Gi1/β1/γ2 6LFM-CXCR2-Interleukin-8-Gi1/β1/γ2 8KFX-CCR8-LMD-009-Gi1/β1/γ2 7F1Q-CCR5-MIP-1a-Gi1/β1/γ2 8HNL-CXCR3-PS372424-Gi1/β1/γ2 8KFY-CCR8-ZK-756326-Gi1/β1/γ2 7O7F-CCR5-6P4-CCL5-Gi1/β1/γ1 8U1U-CCR8-CCL1-Gi1/β1/γ2 7VLA-CCR1-CCL15(27-92)-Gi1/β1/γ2 7XA3-CCR2-CCL2-Gi1/β1/γ2
4.76	Consensus	opioid_on	Orthosteric Ligand	mop_on nop_on dop_on kop_on
4.76	Consensus	pac_on	Orthosteric Ligand	pac1_on
4.76	Consensus	vpac1_on	Orthosteric Ligand	8E3Z-VPAC₁-VIP-Gs/β1/γ2
4.76	Consensus	vpac_on	Orthosteric Ligand	vpac1_on vpac2_on
4.55	Single	4XT3	Fractalkine	4XT3-US28-Fractalkine
4.55	Single	5UIW	5P7-CCL5	5UIW-CCR5-5P7-CCL5
4.55	Single	6FJ3	PTH	6FJ3-PTH1-PTH
4.55	Single	6NBF	Long-Acting PTH Analog	6NBF-PTH1-Long-Acting PTH Analog-Gs/β1/γ2
4.55	Single	6NBI	Long-Acting PTH Analog	6NBI-PTH1-Long-Acting PTH Analog-Gs/β1/γ2
4.55	Single	7KI0	Semaglutide	7KI0-GLP-1-Semaglutide-Gs/β1/γ2
4.55	Single	7RA3	GIP	7RA3-GIP-GIP-chim(NtGi1-Gs)/β1/γ2
4.55	Single	7RGP	Tirzepatide	7RGP-GLP-1-Tirzepatide-chim(NtGi1-Gs)/β1/γ2
4.55	Single	7SK3	CXCL12	7SK3-ACKR3-CXCL12
4.55	Single	7SK4	CXCL12_LRHQ	7SK4-ACKR3-CXCL12_LRHQ
4.55	Single	7VAB	Non-Acylated Tirzepatide	7VAB-GIP-Non-Acylated Tirzepatide-chim(NtGi1-Gs)/β1/γ2
4.55	Single	8E3X	PACAP27	8E3X-PAC₁-PACAP27-Gs/β1/γ2
4.55	Single	8FLR	PTHrP(1-36)	8FLR-PTH1-PTHrP(1-36)-Gs/β1/γ2
4.55	Single	8JIS	Peptide-15	8JIS-GLP-1-Peptide-15-chim(NtGi1-Gs)/β1/γ2
4.55	Single	8XQF	Apelin-13	8XQF-Apelin-Apelin-13-Gi1/β1/γ2
4.55	Single	9BLB	Cagrilintide backbone (non-acylated)	9BLB-CT-Cagrilintide backbone (non-acylated)-Gs/β1/γ2
4.55	Single	9BLW	Cagrilintide backbone (non-acylated)	9BLW-CT (AMY1)-Cagrilintide backbone (non-acylated)-Gs/β1/γ2; RAMP1
4.55	Single	9BP3	Cagrilintide	9BP3-CT (AMY1)-Cagrilintide-Gs/β1/γ2; RAMP1
4.55	Single	9BUB	Cagrilintide	9BUB-CT-Cagrilintide-Gs/β1/γ2
4.55	Single	9J1P	g1:Ox	9J1P-GLP-1-g1:Ox-chim(NtGi1-Gs)/β1/γ2
4.55	Consensus	calcitonin_on_gp	Orthosteric Ligand	ctlike_on_gp
4.55	Consensus	ccr5_off	Orthosteric Ligand	5UIW-CCR5-5P7-CCL5
4.55	Consensus	ccr5_on	Orthosteric Ligand	7O7F-CCR5-6P4-CCL5-Gi1/β1/γ1 7F1Q-CCR5-MIP-1a-Gi1/β1/γ2
4.55	Consensus	ccr_off	Orthosteric Ligand	ccr2_off ccr5_off
4.55	Consensus	crf2_on_gp	Orthosteric Ligand	7TS0-CRF₂-Urocortin-chim(NtGi1L-Go)/β1/γ2
4.55	Consensus	ctlike_on	Orthosteric Ligand	6E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/β1/γ2; RAMP1
4.55	Consensus	gi_compl-pept	Orthosteric Ligand	8HK5-C5a₁-Complement C5-Gi1/β1/γ2 8IA8-C3a_B-E7 peptide-Gi1/β1/γ2 7Y66-C5a₁-BM213-Gi1/β1/γ2 7Y67-C5a₁-C089 peptide-Gi1/β1/γ2 8HK2-C3a_B-C3a anaphylatoxin-Gi1/β1/γ2 7Y64-C5a₁-C5a anaphylatoxin-Gi1/β1/γ2
4.55	Consensus	gi_peptide	Orthosteric Ligand	gi_cck gi_apelin gi_compl-pept gi_endothelin gi_formylpeptide gi_galanin gi_ghrelin gi_npy gi_neurotensin gi_opioid gi_orexin gi_relaxin gi_somatostatin
4.55	Consensus	gi_protein	Orthosteric Ligand	gi_chemokine gi_chemerin
4.55	Consensus	opioid_on_gp	Orthosteric Ligand	mop_on_gp nop_on_gp dop_on_gp kop_on_gp
4.55	Consensus	pac1_on	Orthosteric Ligand	8E3X-PAC₁-PACAP27-Gs/β1/γ2 6M1H-PAC₁-Maxadilan-Gs/β1/γ2
4.55	Consensus	pac1_on_gp	Orthosteric Ligand	8E3X-PAC₁-PACAP27-Gs/β1/γ2 6M1H-PAC₁-Maxadilan-Gs/β1/γ2
4.55	Consensus	pac_on_gp	Orthosteric Ligand	pac1_on_gp
4.55	Consensus	protein_on_gp	Orthosteric Ligand	chemokine_on_gp chemerin_on_gp
4.55	Consensus	vpac1_on_gp	Orthosteric Ligand	8E3Z-VPAC₁-VIP-Gs/β1/γ2
4.55	Consensus	vpac_on_gp	Orthosteric Ligand	vpac1_on_gp vpac2_on_gp
4.35	Single	5NX2	GLP-1 (Truncated)	5NX2-GLP-1-GLP-1 (Truncated)
4.35	Single	6B3J	Exendin-P5	6B3J-GLP-1-Exendin-P5-Gs/β1/γ2
4.35	Single	6UVA	Adrenomedullin-2	6UVA-CT Like (AM2)-Adrenomedullin-2-Gs/β1/γ2; RAMP3
4.35	Single	6VCB	GLP-1	6VCB-GLP-1-GLP-1-LSN3160440-Gs/β1/γ2
4.35	Single	7DTY	GIP	7DTY-GIP-GIP-Gs/β1/γ2
4.35	Single	7F53	Alpha-MSH	7F53-MC₄-α-MSH-Gs/β1/γ2
4.35	Single	7FIY	Tirzepatide	7FIY-GIP-Tirzepatide-Gs/β1/γ2
4.35	Single	7S1M	Ex4-D-Ala	7S1M-GLP-1-Ex4-D-Ala-Gs/β1/γ2
4.35	Single	7TYF	Amylin	7TYF-CT (AMY1)-Amylin-Gs/β1/γ2; RAMP1
4.35	Single	7TYN	Calcitonin-1	7TYN-CT-Calcitonin-1-Gs/β1/γ2
4.35	Single	7VQX	PACAP27	7VQX-VPAC₁-PACAP27-Gs/β1/γ2
4.35	Single	7VVK	PTH	7VVK-PTH1-PTH-Gs/β1/γ2
4.35	Single	7YOO	Neuropeptide-Y	7YOO-Y₂-Neuropeptide-Y-Gi1/β1/γ2
4.35	Single	8FU6	Glucagon derivative ZP3780	8FU6-Glucagon-Glucagon derivative ZP3780-Gs/β1/γ2
4.35	Single	8HAO	PTH	8HAO-PTH1-PTH-chim(NtGi1-Gs)/β1/γ2
4.35	Single	8XFS	R-spondin-2	8XFS-LGR4-R-spondin-2-ZNRF3
4.35	Single	8ZH8	QRF-Amide	8ZH8-QRFP-QRF-Amide-Gq/β1/γ1
4.35	Single	8ZJG	Chemerin	8ZJG-CML1-Chemerin-Gi1/β1/γ2
4.35	Single	9BUC	Cagrilintide	9BUC-CT-Cagrilintide-Gs/β1/γ2
4.35	Single	9K26	PrRP31	9K26-PrRP-PrRP31-Gi1/β1/γ2
4.35	Consensus	crf_on	Orthosteric Ligand	crf2_on crf1_on
4.35	Consensus	glp2_on	Orthosteric Ligand	7D68-GLP-2-GLP-2-Gs/β1/γ2
4.35	Consensus	glp2_on_gp	Orthosteric Ligand	7D68-GLP-2-GLP-2-Gs/β1/γ2
4.35	Consensus	glp_on	Orthosteric Ligand	glp1_on glp2_on
4.35	Consensus	glp_on_gp	Orthosteric Ligand	glp1_on_gp glp2_on_gp
4.35	Consensus	gq_peptide	Orthosteric Ligand	gq_cck gq_kisspeptin gq_bradykinin gq_bombesin gq_angiotensin
4.35	Consensus	npy2_on	Orthosteric Ligand	7YOO-Y₂-Neuropeptide-Y-Gi1/β1/γ2
4.35	Consensus	npy2_on_gp	Orthosteric Ligand	7YOO-Y₂-Neuropeptide-Y-Gi1/β1/γ2
4.35	Consensus	peptide_on	Orthosteric Ligand	cck_on angiotensin_on apelin_on bombesin_on bradykinin_on compl-peptide_on endothelin_on formylpeptide_on galanin_on ghrelin_on kisspeptin_on melanocortin_on motilin_on neuromedin-u_on npy_on neurotensin_on opioid_on orexin_on relaxin_on somatostatin_on tachykinin_on trh_on vasop-oxy_on
4.35	Consensus	peptide_on_gp	Orthosteric Ligand	cck_on_gp angiotensin_on_gp apelin_on_gp bombesin_on_gp bradykinin_on_gp compl-peptide_on_gp endothelin_on_gp formylpeptide_on_gp galanin_on_gp ghrelin_on_gp kisspeptin_on_gp melanocortin_on_gp motilin_on_gp neuromedin-u_on_gp npy_on_gp neurotensin_on_gp opioid_on_gp orexin_on_gp relaxin_on_gp somatostatin_on_gp tachykinin_on_gp trh_on_gp vasop-oxy_on_gp
4.17	Single	5VAI	GLP-1	5VAI-GLP-1-GLP-1-Gs/β1/γ2
4.17	Single	6LMK	Glucagon	6LMK-Glucagon-Glucagon-Gs/β1/γ2
4.17	Single	6LML	Glucagon	6LML-Glucagon-Glucagon-Gi1/β1/γ1
4.17	Single	6NBH	Long-Acting PTH Analog	6NBH-PTH1-Long-Acting PTH Analog-Gs/β1/γ2
4.17	Single	6UUS	Adrenomedullin	6UUS-CT Like (AM2)-Adrenomedullin-Gs/β1/γ2; RAMP3
4.17	Single	6WZG	Secretin	6WZG-Secretin-Secretin-Gs/β1/γ2
4.17	Single	7D68	GLP-2	7D68-GLP-2-GLP-2-Gs/β1/γ2
4.17	Single	7KI1	Taspoglutide	7KI1-GLP-1-Taspoglutide-Gs/β1/γ2
4.17	Single	7TS0	Urocortin	7TS0-CRF₂-Urocortin-chim(NtGi1L-Go)/β1/γ2
4.17	Single	7TYL	Amylin	7TYL-CT-Amylin-Gs/β1/γ2
4.17	Single	7VVJ	PTHrP(1-36)	7VVJ-PTH1-PTHrP(1-36)-Gs/β1/γ2
4.17	Single	7VVL	PTH	7VVL-PTH1-PTH-Gs/β1/γ2
4.17	Single	8F0K	Pramlintide Analogue San385	8F0K-CT (AMY3)-Pramlintide Analogue San385-Gs/β1/γ2; RAMP3
4.17	Single	8HAF	PTHrP(1-36)	8HAF-PTH1-PTHrP(1-36)-chim(NtGi1-Gs)/β1/γ2
4.17	Single	8IY5	Endothelin-1	8IY5-ET_B-Endothelin-1-Gi1/β1/γ2
4.17	Single	8IY6	Endothelin-1	8IY6-ET_B-Endothelin-1
4.17	Single	9BQ3	Cagrilintide	9BQ3-CT (AMY2)-Cagrilintide-Gs/β1/γ2; RAMP2
4.17	Single	9BTW	Cagrilintide	9BTW-CT (AMY3)-Cagrilintide-Gs/β1/γ2; RAMP3
4.17	Single	9BYO	Exendin-3	9BYO-GLP-1-Exendin-3-Gs/β1/γ2
4.17	Consensus	bk2_on	Orthosteric Ligand	7F6H-BK₂-Bradykinin-Gq/β1/γ2 7F6I-BK₂-Kallidin-Gq/β1/γ2
4.17	Consensus	bk2_on_gp	Orthosteric Ligand	7F6H-BK₂-Bradykinin-Gq/β1/γ2 7F6I-BK₂-Kallidin-Gq/β1/γ2
4.17	Consensus	bradykinin_on	Orthosteric Ligand	bk2_on
4.17	Consensus	bradykinin_on_gp	Orthosteric Ligand	bk2_on_gp
4.17	Consensus	ctlike_on_gp	Orthosteric Ligand	6E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/β1/γ2; RAMP1
4.17	Consensus	endothelin_on	Orthosteric Ligand	etb_on eta_on
4.17	Consensus	gq_bradykinin	Orthosteric Ligand	7F6H-BK₂-Bradykinin-Gq/β1/γ2 7F6I-BK₂-Kallidin-Gq/β1/γ2
4.17	Consensus	gs_melanocortin	Orthosteric Ligand	7F4H-MC₁-Afamelanotide-chim(NtGi1-Gs)/β1/γ2 7F54-MC₄-Afamelanotide-Gs/β1/γ2 7F4D-MC₁-α-MSH-chim(NtGi1-Gs)/β1/γ2 8INR-MC₅-α-MSH-Ca-chim(NtGi1-Gs)/β1/γ2 7F53-MC₄-α-MSH-Gs/β1/γ2 7F55-MC₄-Bremelanotide-Gs/β1/γ2 8GY7-MC₂-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1 8IOC-MC₃-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2 8IOD-MC₅-PG-901-Ca-chim(NtGi1-Gs)/β1/γ2 7AUE-MC₄-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2 7F4I-MC₁-SHU9119-chim(NtGi1-Gs)/β1/γ2 7F58-MC₄-THIQ-Gs/β1/γ2
4.17	Consensus	pth1_on	Orthosteric Ligand	6NBF-PTH1-Long-Acting PTH Analog-Gs/β1/γ2 8HA0-PTH1-PTH-chim(NtGi1-Gs)/β1/γ2 8HAF-PTH1-PTHrP(1-36)-chim(NtGi1-Gs)/β1/γ2 7Y36-PTH1-Teriparatide-Gs/β1/γ2 7Y35-PTH1-Abaloparatide-Gs/β1/γ2
4.17	Consensus	vip-pacap_on	Orthosteric Ligand	vpac_on pac_on
4.17	Consensus	vip-pacap_on_gp	Orthosteric Ligand	vpac_on_gp pac_on_gp
4.17	Consensus	vpac2_on	Orthosteric Ligand	7VQX-VPAC₁-PACAP27-Gs/β1/γ2
4.17	Consensus	vpac2_on_gp	Orthosteric Ligand	7VQX-VPAC₁-PACAP27-Gs/β1/γ2
4.00	Single	5GLH	Endothelin-1	5GLH-ET_B-Endothelin-1
4.00	Single	6IGK	Endothelin-3	6IGK-ET_B-Endothelin-3
4.00	Single	7DUQ	GLP-1	7DUQ-GLP-1-GLP-1-PubChem 156022738-Gs/β1/γ2
4.00	Single	7RBT	Tirzepatide	7RBT-GIP-Tirzepatide-LSN3556672-chim(NtGi1-Gs)/β1/γ2
4.00	Single	7TYX	Amylin	7TYX-CT (AMY2)-Amylin-Gs/β1/γ2; RAMP2
4.00	Single	8U1U	CCL1	8U1U-CCR8-CCL1-Gi1/β1/γ2
4.00	Consensus	ccr5_on_gp	Orthosteric Ligand	7O7F-CCR5-6P4-CCL5-Gi1/β1/γ1 7F1Q-CCR5-MIP-1a-Gi1/β1/γ2
4.00	Consensus	class-a_class-b1_cons_on	Orthosteric Ligand	class-a_on class-b1_on
4.00	Consensus	gi_npy	Orthosteric Ligand	8K6M-Y₁-Neuropeptide-Y-Gi2/β1/γ1 7X9C-Y₄-Pancreatic Hormone-Gi1/β1/γ2 7YOO-Y₂-Neuropeptide-Y-Gi1/β1/γ2
4.00	Consensus	gip_on	Orthosteric Ligand	7FIN-GIP-Peptide-20; GGL-Gs/β1/γ2 7FIY-GIP-Tirzepatide-Gs/β1/γ2 7DTY-GIP-GIP-Gs/β1/γ2
4.00	Consensus	gip_on_gp	Orthosteric Ligand	7FIN-GIP-Peptide-20; GGL-Gs/β1/γ2 7FIY-GIP-Tirzepatide-Gs/β1/γ2 7DTY-GIP-GIP-Gs/β1/γ2
4.00	Consensus	npy_on	Orthosteric Ligand	npy1_on npy2_on npy4_on
4.00	Consensus	npy_on_gp	Orthosteric Ligand	npy1_on_gp npy2_on_gp npy4_on_gp
3.85	Single	6LPB	PACAP	6LPB-PAC₁-PACAP-Gs/β1/γ1
3.85	Single	7SK6	CXCL12_LRHQ	7SK6-ACKR3-CXCL12_LRHQ
3.85	Single	7TZF	Amylin	7TZF-CT (AMY3)-Amylin-Gs/β1/γ2; RAMP3
3.85	Single	7VBH	Peptide-20	7VBH-GLP-1-Peptide-20-Gs/β1/γ2
3.85	Single	8F2A	Pramlintide Analogue San385	8F2A-CT (AMY3)-Pramlintide Analogue San385-Gs/β1/γ2; RAMP3
3.85	Single	8FLS	Abaloparatide	8FLS-PTH1-Abaloparatide-Gs/β1/γ2
3.85	Single	8FLU	Long-Acting PTH	8FLU-PTH1-Long-Acting PTH-Gs/β1/γ2
3.85	Single	9AUC	Calcitonin gene-related peptide-1	9AUC-CT (AMY1)-Calcitonin gene-related peptide-1-Gs/β1/γ2; RAMP1
3.85	Consensus	endothelin_on_gp	Orthosteric Ligand	etb_on_gp eta_on_gp
3.85	Consensus	glp1_on	Orthosteric Ligand	7S1M-GLP-1-Ex4-D-Ala-Gs/β1/γ2 7X8R-GLP-1-BOC5-Gs/β1/γ2 6X19-GLP-1-CHU-128-Gs/β1/γ2 6X1A-GLP-1-Danuglipron-Gs/β1/γ2 6X18-GLP-1-GLP-1-Gs/β1/γ2 8JIP-GLP-1-MEDI0382-chim(NtGi1-Gs)/β1/γ2 7C2E-GLP-1-PubChem 149050799-Gs/β1/γ2 7KI0-GLP-1-Semaglutide-Gs/β1/γ2 7KI1-GLP-1-Taspoglutide-Gs/β1/γ2 7X8S-GLP-1-WB4-24-Gs/β1/γ2 8JIS-GLP-1-Peptide-15-chim(NtGi1-Gs)/β1/γ2 7VBI-GLP-1-Non-Acylated Tirzepatide-Gs/β1/γ2
3.85	Consensus	melanocortin_on	Orthosteric Ligand	mc1_on mc4_on mc2_on mc3_on mc5_on
3.85	Consensus	melanocortin_on_gp	Orthosteric Ligand	mc1_on_gp mc4_on_gp mc2_on_gp mc3_on_gp mc5_on_gp
3.70	Single	6LRY	Sarafotoxin-B	6LRY-ET_B-Sarafotoxin-B
3.70	Single	6WPW	Glucagon derivative ZP3780	6WPW-Glucagon-Glucagon derivative ZP3780-Gs/β1/γ2
3.70	Single	7V35	Peptide-20	7V35-Glucagon-Peptide-20-Gs/β1/γ2
3.70	Single	7VVM	PTH	7VVM-PTH1-PTH-Gs/β1/γ2
3.70	Single	8JIP	MEDI0382	8JIP-GLP-1-MEDI0382-chim(NtGi1-Gs)/β1/γ2
3.70	Single	8JIR	SAR425899	8JIR-GLP-1-SAR425899-chim(NtGi1-Gs)/β1/γ2
3.70	Single	9JR2	PTH	9JR2-PTH1-PTH-chim(NtGi1L-Gs-CtGq)/β1/γ2
3.70	Consensus	crf_on_gp	Orthosteric Ligand	crf2_on_gp crf1_on_gp
3.70	Consensus	glp1_on_gp	Orthosteric Ligand	7S1M-GLP-1-Ex4-D-Ala-Gs/β1/γ2 7X8R-GLP-1-BOC5-Gs/β1/γ2 6X19-GLP-1-CHU-128-Gs/β1/γ2 6X1A-GLP-1-Danuglipron-Gs/β1/γ2 6X18-GLP-1-GLP-1-Gs/β1/γ2 8JIP-GLP-1-MEDI0382-chim(NtGi1-Gs)/β1/γ2 7C2E-GLP-1-PubChem 149050799-Gs/β1/γ2 7KI0-GLP-1-Semaglutide-Gs/β1/γ2 7KI1-GLP-1-Taspoglutide-Gs/β1/γ2 7X8S-GLP-1-WB4-24-Gs/β1/γ2 8JIS-GLP-1-Peptide-15-chim(NtGi1-Gs)/β1/γ2 7VBI-GLP-1-Non-Acylated Tirzepatide-Gs/β1/γ2
3.70	Consensus	pth1_on_gp	Orthosteric Ligand	6NBF-PTH1-Long-Acting PTH Analog-Gs/β1/γ2 8HA0-PTH1-PTH-chim(NtGi1-Gs)/β1/γ2 8HAF-PTH1-PTHrP(1-36)-chim(NtGi1-Gs)/β1/γ2 7Y36-PTH1-Teriparatide-Gs/β1/γ2 7Y35-PTH1-Abaloparatide-Gs/β1/γ2
3.57	Single	7TYO	Calcitonin	7TYO-CT-Calcitonin-Gs/β1/γ2
3.57	Single	7TYY	Calcitonin-1	7TYY-CT (AMY2)-Calcitonin-1-Gs/β1/γ2; RAMP2
3.57	Single	7X9A	Neuropeptide-Y	7X9A-Y₁-Neuropeptide-Y-Gi1/β1/γ2
3.57	Single	7Y36	Teriparatide	7Y36-PTH1-Teriparatide-Gs/β1/γ2
3.57	Single	8FLQ	PTH	8FLQ-PTH1-PTH-Gs/β1/γ2
3.57	Single	8JIT	MEDI0382	8JIT-Glucagon-MEDI0382-Gs/β1/γ2
3.57	Single	8JIU	SAR425899	8JIU-Glucagon-SAR425899-Gs/β1/γ2
3.57	Single	9JR3	PTH	9JR3-PTH1-PTH-chim(NtGi1L-Gs-CtGq)/β1/γ2
3.57	Consensus	class-a_class-b1_cons_on_gp	Orthosteric Ligand	class-a_on_gp class-b1_on_gp
3.57	Consensus	glucagon_on	Orthosteric Ligand	glp_on gluc_on secretin_on gip_on
3.57	Consensus	pth2_on	Orthosteric Ligand	7F16-PTH2-TIP39-Gs/β1/γ2
3.45	Single	6E3Y	Calcitonin gene-related peptide-1	6E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/β1/γ2; RAMP1
3.45	Consensus	gluc_on	Orthosteric Ligand	6LMK-Glucagon-Glucagon-Gs/β1/γ2 8JIT-Glucagon-MEDI0382-Gs/β1/γ2 7V35-Glucagon-Peptide-20-Gs/β1/γ2
3.45	Consensus	glucagon_on_gp	Orthosteric Ligand	glp_on_gp gluc_on_gp secretin_on_gp gip_on_gp
3.45	Consensus	pth_on	Orthosteric Ligand	pth1_on pth2_on
3.33	Consensus	gluc_on_gp	Orthosteric Ligand	6LMK-Glucagon-Glucagon-Gs/β1/γ2 8JIT-Glucagon-MEDI0382-Gs/β1/γ2 7V35-Glucagon-Peptide-20-Gs/β1/γ2
3.33	Consensus	mc2_on	Orthosteric Ligand	8GY7-MC₂-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1
3.33	Consensus	mc2_on_gp	Orthosteric Ligand	8GY7-MC₂-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1
3.23	Single	7F16	TIP39	7F16-PTH2-TIP39-Gs/β1/γ2
3.23	Consensus	class-b1_on	Orthosteric Ligand	glucagon_on vip-pacap_on pth_on crf_on calcitonin_on
3.23	Consensus	pth2_on_gp	Orthosteric Ligand	7F16-PTH2-TIP39-Gs/β1/γ2
3.12	Single	8F0J	Pramlintide Analogue San45	8F0J-CT-Pramlintide Analogue San45-Gs/β1/γ2
3.03	Single	8F2B	Pramlintide Analogue San45	8F2B-CT (AMY3)-Pramlintide Analogue San45-Gs/β1/γ2; RAMP3
3.03	Consensus	pth_on_gp	Orthosteric Ligand	pth1_on_gp pth2_on_gp
2.86	Consensus	class-b1_on_gp	Orthosteric Ligand	glucagon_on_gp vip-pacap_on_gp pth_on_gp crf_on_gp calcitonin_on_gp
2.78	Single	8GY7	Corticotropin	8GY7-MC₂-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1

PDB Summary
PDB	6D32
Class	F
SubFamily	Protein
Type	Frizzled
SubType	SMO
Species	Xenopus Laevis
Ligand	Cyclopamine
Other Ligand(s)	Cyclopamine
Protein Partners	-
PDB Resolution	3.75
Date	2018-05-23
D.O.I.	doi.org/10.1016/j.cell.2018.04.029

Net Summary
I_min	2.85
Number of Linked Nodes	435
Number of Links	550
Number of Hubs	94
Number of Links mediated by Hubs	321
Number of Communities	16
Number of Nodes involved in Communities	147
Number of Links involved in Communities	221

Path Summary
Number Of Nodes in MetaPath	67
Number Of Links MetaPath	66
Number of Shortest Paths	268183
Length Of Smallest Path	3
Average Path Length	19.252
Length of Longest Path	38
Minimum Path Strength	1.17
Average Path Strength	6.69774
Maximum Path Strength	22.965
Minimum Path Correlation	0.71
Average Path Correlation	0.961896
Maximum Path Correlation	1
Minimum % Of Corr. Nodes	3.57143
Average % Of Corr. Nodes	56.8276
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	49.2993
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process
Gene Ontology	Cellular Component
SCOP2	Domain Identifier	• Cytochromes
SCOP2	Family Identifier	• Cytochromes
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	CY8
PDB Residues	L:L:?1 W:W:?3
Environment Details	Open EMBL-EBI Page
Code	CY8
Name	Cyclopamine
Synonyms	(3alpha,8alpha,14beta,22S,23R)-17,23-epoxyveratraman-3-ol
Identifier
Formula	C27 H41 N O2
Molecular Weight	411.62
SMILES
PubChem	442972
Formal Charge	0
Total Atoms	71
Total Chiral Atoms	10
Total Bonds	76
Total Aromatic Bonds	0


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	A0A1L8GTP2
Sequence	>6D32_Chain_R K C K K T T T C E P L K Y N I C L G S V L P Y A L T S T V L A E D S S S Q D E V H D K L S L W S G L R N A P R C W D A I R P L L C A V Y M P K C E G G K V E L P S Q G L C Q T T R V P C A I V A R E R G W P D F L K C T T D Y F P E G C P N E V Q N I K F N S A G Q C E A P L V R T D N P K S W Y E D V E G C G I Q C Q N P L F T N K E H R E M H I Y I A I F S S V T I F C T F F T L A T F L V D W K N S N R Y P A V I L F Y V N A C F F A G S I G W L A Q F M D G A R D E I V C R G D G T M R L G E P T S S E T L S C V I I F I I V Y Y S M M S G V I W F V M L T Y A W H T S F K A L S G K T S Y F H L I T W S I P F V L T V A I L A V A Q V D G D S V S G I C F V G Y K N Y H Y R A G F V L A P I G L V L I G G G Y F L I R G V M T L F S S K I N E T M L R L G I F G F L A F G F V L I T F G C H F Y D F F N Q A E W E R S F R E Y V L C E A N V A I A E Q T N K P I P E C Y I K N R P S L L V E K I N L F A M F G T G I S M S T W V W T K A T I I I W K R A W C R I Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	4N4W	F	Protein	Frizzled	SMO	Homo sapiens	-	SANT-1	-	2.8	2014-01-22	doi.org/10.1038/ncomms5355
	6D32	F	Protein	Frizzled	SMO	Xenopus laevis	Cyclopamine	Cyclopamine	-	3.75	2018-05-23	doi.org/10.1016/j.cell.2018.04.029
	6D35	F	Protein	Frizzled	SMO	Xenopus laevis	-	Cholesterol	-	3.9	2018-05-23	doi.org/10.1016/j.cell.2018.04.029
	5L7D	F	Protein	Frizzled	SMO	Homo sapiens	-	Cholesterol	-	3.2	2016-07-20	doi.org/10.1038/nature18934
	6O3C	F	Protein	Frizzled	SMO	Mus musculus	SAG21k	Cholesterol	-	2.8	2019-07-03	doi.org/10.1038/s41586-019-1355-4
	6XBJ	F	Protein	Frizzled	SMO	Homo sapiens	-	Cholesterol	Gi1/β1/γ2	3.88	2020-09-30	doi.org/10.1038/s41589-020-0646-2
	6XBJ (No Gprot)	F	Protein	Frizzled	SMO	Homo sapiens	-	Cholesterol		3.88	2020-09-30	doi.org/10.1038/s41589-020-0646-2
	6XBK	F	Protein	Frizzled	SMO	Homo sapiens	-	Cholesterol	Gi1/β1/γ2	3.24	2020-09-30	doi.org/10.1038/s41589-020-0646-2
	6XBK (No Gprot)	F	Protein	Frizzled	SMO	Homo sapiens	-	Cholesterol		3.24	2020-09-30	doi.org/10.1038/s41589-020-0646-2
	6XBL	F	Protein	Frizzled	SMO	Homo sapiens	SAG	Cholesterol	Gi1/β1/γ2	3.96	2020-09-30	doi.org/10.1038/s41589-020-0646-2
	6XBL (No Gprot)	F	Protein	Frizzled	SMO	Homo sapiens	SAG	Cholesterol		3.96	2020-09-30	doi.org/10.1038/s41589-020-0646-2
	7ZI0	F	Protein	Frizzled	SMO	Homo sapiens	SAG	Cholesterol	-	3	2022-06-15	doi.org/10.1126/sciadv.abm5563
	6XBM	F	Protein	Frizzled	SMO	Homo sapiens	-	5LWE	Gi1/β1/γ2	3.14	2020-09-30	doi.org/10.1038/s41589-020-0646-2
	6XBM (No Gprot)	F	Protein	Frizzled	SMO	Homo sapiens	-	5LWE		3.14	2020-09-30	doi.org/10.1038/s41589-020-0646-2
	6OT0	F	Protein	Frizzled	SMO	Homo sapiens	-	25(S)-Epoxycholesterol	Gi1/β1/γ2	3.84	2019-06-12	doi.org/10.1038/s41586-019-1286-0
	6OT0 (No Gprot)	F	Protein	Frizzled	SMO	Homo sapiens	-	25(S)-Epoxycholesterol		3.84	2019-06-12	doi.org/10.1038/s41586-019-1286-0
	4JKV	F	Protein	Frizzled	SMO	Homo sapiens	Taladegib	-	-	2.45	2013-04-24	doi.org/10.1038/nature12167
	5L7I	F	Protein	Frizzled	SMO	Homo sapiens	Vismodegib	-	-	3.3	2016-07-20	doi.org/10.1038/nature18934
	5V56	F	Protein	Frizzled	SMO	Homo sapiens	TC114	-	-	2.9	2017-05-24	doi.org/10.1038/ncomms15383
	5V57	F	Protein	Frizzled	SMO	Homo sapiens	TC114	-	-	3	2017-05-24	doi.org/10.1038/ncomms15383
	4O9R	F	Protein	Frizzled	SMO	Homo sapiens	Cyclopamine	-	-	3.2	2014-03-05	doi.org/10.1038/ncomms4309
	4QIM	F	Protein	Frizzled	SMO	Homo sapiens	ANTA XV	-	-	2.61	2014-07-23	doi.org/10.1038/ncomms5355
	4QIN	F	Protein	Frizzled	SMO	Homo sapiens	SAG1.5	-	-	2.6	2014-07-23	doi.org/10.1038/ncomms5355
	8CXO	F	Protein	Frizzled	SMO	Mus musculus	-	-	-	3.7	2022-08-03	doi.org/10.1038/s41467-022-32125-2

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