Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg Int. Strength Num Of Links Community ConSurf
1N:N:L4 4.4845110
2N:N:Q6 6.48754260
3N:N:P7 3.736676260
4N:N:V11 4.1165260
5N:N:I28 4.6985110
6N:N:N31 6.968510
7N:N:W35 7.4765110
8N:N:Y36 6.1925410
9N:N:Q37 9.3400
10N:N:Q38 8.065410
11N:N:L46 6.9925410
12N:N:Y49 11.7017610
13N:N:Y50 5.0825410
14N:N:Q53 8.13410
15N:N:R61 6.725717200
16N:N:F62 6.1165200
17N:N:I75 5.84200
18N:N:D82 6.6465200
19N:N:Y86 6.844200
20N:N:Y87 6.285610
21N:N:T89 8.78410
22N:N:W91 6.57610
23N:N:L95 4.25754110
24N:N:Q98 10.9510
25N:N:L99 3.8254110
26N:N:F100 11.53410
27N:N:T104 7.61754260
28N:N:P116 4.235660
29N:N:F121 5.6075480
30N:N:P123 9.9625460
31N:N:E127 8.396580
32N:N:T134 7.21400
33N:N:L135 6.35667660
34N:N:V136 5.93167680
35N:N:F142 9.6625460
36N:N:Y143 5.97500
37N:N:W151 10.258560
38N:N:Q170 5.7445270
39N:N:Y175 7.605400
40N:N:Y180 5.85833680
41N:N:L181 7.904560
42N:N:L183 8.1875460
43N:N:W188 9.49333660
44N:N:H191 6.262560
45N:N:Y194 8.364560
46N:N:V198 4.4075460
47N:N:H200 6.294560
48L:L:Q6 6.528500
49L:L:L18 7.224120
50L:L:I20 5.194120
51L:L:Y27 9.35410
52L:L:R28 8.324510
53L:L:F29 9.95400
54L:L:Y32 8.42410
55L:L:N35 7.7625410
56L:L:W36 7.825120
57L:L:V37 4.8275410
58L:L:R38 11.205400
59L:L:Q39 7.695410
60L:L:L45 9.17410
61L:L:W47 7.87143710
62L:L:M48 5.4665120
63L:L:R50 12.888510
64L:L:I51 3.8975400
65L:L:D52 6.664510
66L:L:T54 7.435410
67L:L:D55 6.58410
68L:L:Y57 8.41222910
69L:L:Y60 5.8825360
70L:L:I76 6.16754280
71L:L:Y80 8.6025400
72L:L:L81 8.8285120
73L:L:W83 9.096120
74L:L:Y94 9.7475400
75L:L:Y95 7.17667610
76L:L:C96 7.264120
77L:L:R98 10.44510
78L:L:L99 6.1375400
79L:L:E100 6.16667610
80L:L:Y103 8.29375810
81L:L:W107 10.3429710
82L:L:S108 5.175410
83L:L:W111 8.485610
84L:L:P127 5.6254150
85L:L:V129 4.3975400
86L:L:F130 5.825480
87L:L:P131 7.45400
88L:L:L132 7.24480
89L:L:P134 3.3975400
90L:L:L146 6.4025400
91L:L:L149 5.34667680
92L:L:K151 7.84333680
93L:L:D152 5.845480
94L:L:Y153 8.666676150
95L:L:P155 9.4425400
96L:L:W162 7.0885330
97L:L:F174 5.806500
98L:L:Q179 8.2125480
99L:L:Y184 11.60754150
100L:L:S196 3.72754370
101L:L:L197 2.4425400
102L:L:Y202 7.59254370
103L:L:H208 9.96400
104R:R:P48 4.6725409
105R:R:P51 3.9154385
106R:R:L57 4.75407
107R:R:K58 6.6525415
108R:R:I67 4.2875445
109R:R:F72 5.54549
110R:R:R80 12.7167614
111R:R:Y82 9.918514
112R:R:D86 5.9675448
113R:R:L92 4.5625448
114R:R:F97 6.064549
115R:R:H105 7.775617
116R:R:E107 6.37833616
117R:R:R109 10.714515
118R:R:Y116 5.06754393
119R:R:K129 8.514515
120R:R:F130 5.718516
121R:R:F134 9.45515
122R:R:T136 5.345649
123R:R:L138 5.92448
124R:R:F141 5.43375847
125R:R:P142 4.78429749
126R:R:L144 5.2575447
127R:R:K146 4.6404
128R:R:F153 6.0425405
129R:R:F154 5.435646
130R:R:I155 4.375415
131R:R:L156 4.648547
132R:R:E157 9.712518
133R:R:I158 4.985647
134R:R:T159 7.1075415
135R:R:N161 5.11548
136R:R:M164 5.658547
137R:R:I167 4.94407
138R:R:P168 3.6225406
139R:R:F172 6.6575408
140R:R:L175 6.3625447
141R:R:K183 6.4775416
142R:R:L184 5.0075448
143R:R:Y185 8.15833617
144R:R:N187 7.01333649
145R:R:F189 8.68333648
146R:R:Y195 54234
147R:R:F197 6.19754199
148R:R:N198 9.9756237
149R:R:L202 6.1925408
150R:R:Y206 7.586516
151R:R:N208 9.175415
152R:R:K209 9.6625417
153R:R:N210 4.9325449
154R:R:F221 5.353336199
155R:R:P228 4.92254198
156R:R:L231 2.8754197
157R:R:D232 11.4525419
158R:R:S234 5.0925419
159R:R:E251 7.3125415
160R:R:L252 3.1154199
161R:R:I253 7.4475414
162R:R:R255 9.76404
163R:R:R274 3.8413
164R:R:L277 3.5575409
165R:R:Y279 8.3625409
166R:R:P400 3.24754429
167R:R:F405 5.656558
168R:R:R418 7.43754169
169R:R:Y444 9.1645257
170R:R:F451 5.4954449
171R:R:L456 6.60754249
172R:R:D460 7.195249
173R:R:Y466 8.82409
174R:R:D474 7.5645169
175R:R:Y481 6.618336168
176R:R:Y482 7.21754418
177R:R:W488 6.168336169
178R:R:V502 4.255459
179R:R:Y510 5.905407
180R:R:R519 9.3975409
181R:R:W520 6.065407
182R:R:M527 5.874178
183R:R:M542 8.5154449
184R:R:W546 7.7675409
185R:R:Y563 8.08167659
186R:R:L570 5.702559
187R:R:P571 5.3775459
188R:R:D573 6.1875458
189R:R:Y582 5.51167659
190R:R:F594 7.82408
191R:R:Y601 7.98509
192R:R:Y605 5.0625459
193R:R:D633 6.15408
194R:R:V656 4.7125457
195R:R:Y667 5.75857759
196R:R:N674 8.01754249
197R:R:L677 4.0354249
198R:R:Y678 5.753336249
199R:R:F685 5.826439
200R:R:R687 11.68254257
201R:R:D688 7.96254259
202R:R:I691 2.56754256
203A:A:Y37 9.6825434
204A:A:N50 8.32754299
205A:A:S51 4.1554109
206A:A:K53 6.5925109
207A:A:F219 6.701676178
208A:A:F222 13.205427
209A:A:Q227 5.06729
210A:A:R232 6.72428
211A:A:K233 6.77857729
212A:A:W234 6.58833629
213A:A:C237 5.988528
214A:A:F238 8.13857729
215A:A:F246 4.782867149
216A:A:V247 5.174107
217A:A:R265 8.6545299
218A:A:F273 5.566676149
219A:A:I276 4.15254148
220A:A:W277 10.5285146
221A:A:W281 13.4367625
222A:A:I288 5.3275409
223A:A:L289 5.87254149
224A:A:F290 5.571676109
225A:A:N292 4.845409
226A:A:Q294 6.76754216
227A:A:L297 4.325408
228A:A:F312 5.1225308
229A:A:E314 104306
230A:A:F315 12.285406
231A:A:F340 12.2885307
232A:A:R342 7.7054214
233A:A:F345 8.0465148
234A:A:C359 3.4925405
235A:A:Y360 10.6075408
236A:A:F363 7.7265215
237A:A:N371 6.56754109
238A:A:R374 6.98254104
239A:A:F376 5.391258178
240A:A:Y391 8.076504
241B:B:E10 8.12754348
242B:B:L14 6.19254348
243B:B:I37 5.59254222
244B:B:V40 4.9525223
245B:B:H54 8.61167639
246B:B:K57 12.594529
247B:B:Y59 10.558528
248B:B:M61 4.2425436
249B:B:W63 6.21857737
250B:B:V71 5.50254318
251B:B:Q75 12.395429
252B:B:D76 8.134539
253B:B:K78 6.355408
254B:B:I81 5.424317
255B:B:W82 10.04639
256B:B:D83 10.3275438
257B:B:N88 9.1875437
258B:B:K89 6.97667639
259B:B:L95 5.0445328
260B:B:W99 10.0983629
261B:B:M101 5.8175429
262B:B:Y105 4.55758316
263B:B:N110 6.53424
264B:B:Y111 6.354524
265B:B:C114 5.3754328
266B:B:L117 5.572529
267B:B:C121 3.644528
268B:B:I123 4.384526
269B:B:Y124 6.735326
270B:B:E138 6.4725406
271B:B:H142 9.605429
272B:B:Y145 7.71728
273B:B:C148 3.5425496
274B:B:F151 5.50714729
275B:B:I157 5.276527
276B:B:T159 6.7625429
277B:B:S160 5.5475496
278B:B:D163 9.12429
279B:B:C166 4.585498
280B:B:W169 9.86667628
281B:B:Q176 8.0775424
282B:B:F180 9.35597
283B:B:H183 8.015699
284B:B:D186 7.185429
285B:B:V187 4.3375499
286B:B:L190 5.38495
287B:B:F199 8.994599
288B:B:V200 8.61476
289B:B:S201 4.915499
290B:B:C204 6.2527
291B:B:D205 7.01499
292B:B:K209 11.725496
293B:B:L210 5.4475405
294B:B:W211 9.55333698
295B:B:F222 6.692578
296B:B:H225 9.18571779
297B:B:D228 8.406529
298B:B:I232 5.72478
299B:B:F234 7.0725405
300B:B:F235 7.8956186
301B:B:P236 6.7254187
302B:B:F241 8.448576
303B:B:T243 6.2775478
304B:B:D247 8.152579
305B:B:T249 7.855476
306B:B:R251 11.7733678
307B:B:F253 7.32667676
308B:B:D254 5.41754189
309B:B:D258 8.17577
310B:B:M262 5.4825404
311B:B:T263 8.27471
312B:B:Y264 8.532505
313B:B:I269 4.1525424
314B:B:F278 6.0345187
315B:B:R283 8.296229
316B:B:L284 5.08405
317B:B:L285 5.8175406
318B:B:Y289 7.58727
319B:B:D290 6.32667626
320B:B:C294 4.075135
321B:B:N295 8.5275426
322B:B:L300 6.19254226
323B:B:K301 5.765405
324B:B:H311 9.0945139
325B:B:R314 14.146528
326B:B:V315 4.0454137
327B:B:W332 11.33729
328B:B:D333 9.13254139
329B:B:L336 5.545407
330B:B:K337 9.1465136
331B:B:I338 4.4575435
332B:B:W339 10.0745139
333G:G:R27 7.254578
334G:G:Y40 11.87754186
335G:G:D48 6.93509
336G:G:P49 3.8725407
337G:G:L51 4.63506
338G:G:P60 6.268539
339G:G:F61 5.08444938
340W:W:?1 8.138121650
341H:H:?1 11.715230
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
1L:L:F64 L:L:S61 12.44383.96NoNo000
2L:L:S61 L:L:W47 12.62714.94NoYes000
3L:L:W47 N:N:Q98 12.522517.52YesYes100
4N:N:F100 N:N:Q98 93.438210.54YesYes100
5L:L:L45 N:N:F100 10012.18YesYes100
6L:L:L45 N:N:Y87 10010.55YesYes100
7N:N:G103 N:N:Y87 1004.35NoYes000
8N:N:G103 N:N:Q6 1006.58NoYes000
9N:N:P7 N:N:Q6 1004.74YesYes2600
10N:N:P7 N:N:V11 1003.53YesYes2600
11N:N:V11 N:N:V19 1003.21YesNo000
12N:N:I75 N:N:V19 1003.07YesNo000
13N:N:I75 N:N:L73 69.56597.14YesNo000
14N:N:L73 N:N:W35 56.102913.67NoYes000
15N:N:C23 N:N:W35 20.19713.92NoYes1100
16L:L:L45 L:L:V37 1005.96YesYes100
17N:N:Q6 N:N:T104 10011.34YesYes2600
18N:N:T104 N:N:V11 1004.76YesYes2600
19N:N:C23 N:N:L4 17.95314.76NoYes1100
20N:N:C88 N:N:W35 20.19717.84NoYes1100
21N:N:C88 N:N:L4 17.95313.17NoYes1100
22N:N:V33 N:N:W35 11.22074.9NoYes1100
23N:N:L78 N:N:V19 1005.96NoNo000
24N:N:G13 N:N:L78 1001.71NoNo000
25N:N:G13 N:N:S12 1001.86NoNo000
26N:N:L109 N:N:S12 1004.5NoNo000
27N:N:F62 N:N:I75 51.61198.79YesYes2000
28N:N:F62 N:N:R61 17.95263.21YesYes2000
29N:N:R61 N:N:R76 17.95252.13YesNo000
30N:N:D82 N:N:I75 44.87994.2YesYes2000
31N:N:D82 N:N:R61 17.952310.72YesYes2000
32N:N:G64 N:N:L73 11.22091.71NoNo000
33L:L:T106 N:N:Q98 10011.34NoYes100
34L:L:T106 N:N:N34 1004.39NoNo000
35L:L:W107 N:N:N34 1003.39YesNo000
36N:N:T89 N:N:Y36 1003.75YesYes100
37N:N:L46 N:N:Y36 1008.21YesYes100
38L:L:V37 L:L:W111 1003.68YesYes100
39N:N:F62 N:N:L47 11.22046.09YesNo000
40N:N:L39 N:N:Q37 13.46456.65NoYes000
41N:N:F62 N:N:Y86 20.19664.13YesYes2000
42N:N:Q37 N:N:Y86 17.952615.78YesYes000
43N:N:D82 N:N:Y86 20.19673.45YesYes2000
44N:N:A84 N:N:Y86 17.95274NoYes000
45L:L:W111 N:N:P44 10016.21YesNo100
46N:N:Q38 N:N:Y87 1006.76YesYes100
47N:N:P44 N:N:Q38 1009.47NoYes100
48L:L:W111 L:L:Y95 1006.75YesYes100
49L:L:Y95 N:N:Q38 1004.51YesYes100
50N:N:K42 N:N:L39 11.22044.23NoNo000
51N:N:L46 N:N:Y49 1005.86YesYes100
52N:N:Q53 N:N:Y49 10011.27YesYes100
53L:L:W107 R:R:Y185 1005.79YesYes107
54R:R:N208 R:R:Y185 1009.3YesYes157
55R:R:N208 R:R:S234 1005.96YesYes159
56R:R:R255 R:R:S234 1003.95YesYes049
57R:R:Y185 R:R:Y206 10013.9YesYes176
58R:R:L230 R:R:Y206 1008.21NoYes146
59R:R:E251 R:R:L230 10013.25YesNo154
60R:R:E251 R:R:R274 1003.49YesYes153
61N:N:L4 N:N:L99 26.92982.77YesYes1100
62N:N:L109 N:N:Y143 1002.34NoYes000
63N:N:Y143 N:N:Y175 1003.97YesYes000
64N:N:F142 N:N:Y175 10011.35YesYes000
65N:N:F142 N:N:P116 1007.22YesYes600
66N:N:I139 N:N:P116 1003.39NoYes600
67N:N:P116 N:N:V198 1003.53YesYes600
68N:N:P144 N:N:Y143 11.20679.74NoYes000
69N:N:A177 N:N:I139 1003.25NoNo000
70N:N:A177 N:N:T165 1001.68NoNo000
71N:N:S178 N:N:T165 1006.4NoNo000
72N:N:S178 N:N:Y180 1006.36NoYes000
73N:N:V136 N:N:Y180 40.35177.57YesYes800
74N:N:F121 N:N:V136 22.42043.93YesYes800
75L:L:V177 N:N:T165 1003.17NoNo000
76L:L:V177 N:N:Y180 1005.05NoYes000
77L:L:F174 N:N:S178 42.6085.28YesNo000
78L:L:F174 N:N:L138 13.458815.83YesNo000
79N:N:F121 N:N:L138 11.20943.65YesNo800
80N:N:F121 N:N:T119 26.9063.89YesNo000
81N:N:V149 N:N:V198 1003.21NoYes600
82N:N:S179 N:N:V149 1009.7NoNo600
83N:N:S179 N:N:W151 1003.71NoYes600
84N:N:C196 N:N:W151 13.465411.75NoYes600
85L:L:L132 N:N:V136 13.450810.43YesYes800
86L:L:L149 N:N:Y180 1003.52YesYes800
87L:L:L132 L:L:L149 13.45514.15YesYes800
88N:N:L135 N:N:W151 65.077210.25YesYes600
89N:N:L135 N:N:W188 11.22053.42YesYes600
90N:N:T134 N:N:Y180 1003.75YesYes000
91N:N:E127 N:N:T134 1009.88YesYes000
92L:L:L149 N:N:E127 1003.98YesYes800
93N:N:E127 N:N:S124 1004.31YesNo800
94L:L:F130 N:N:E127 17.934811.66YesYes800
95L:L:K151 N:N:T134 49.319612.01YesYes000
96L:L:F130 L:L:K151 17.9393.72YesYes800
97L:L:K151 L:L:L149 49.32148.46YesYes800
98L:L:P131 N:N:S124 1003.56YesNo000
99L:L:P131 N:N:E126 26.903712.58YesNo000
100L:L:D152 L:L:K151 26.90366.91YesYes800
101N:N:L181 N:N:W151 17.952318.22YesYes600
102N:N:L135 N:N:L183 11.22054.15YesYes600
103N:N:L181 N:N:L183 11.220611.07YesYes600
104N:N:L135 N:N:Y194 33.66128.21YesYes600
105L:L:F174 N:N:A176 15.70492.77YesNo000
106N:N:A176 N:N:Q170 13.46144.55NoYes000
107N:N:H191 N:N:Y194 29.174311.98YesYes600
108N:N:H191 N:N:S156 11.22115.58YesNo000
109N:N:D154 N:N:H191 13.46535.04NoYes000
110L:L:K151 L:L:Q179 35.87146.78YesYes800
111L:L:Q179 N:N:E163 17.935810.19YesNo000
112N:N:L183 N:N:Q187 17.95319.32YesNo000
113N:N:Q187 N:N:T184 13.464915.59NoNo000
114L:L:K217 L:L:P131 1008.36NoYes000
115L:L:K217 L:L:V129 1004.55NoYes000
116L:L:V129 L:L:V206 1006.41YesNo000
117L:L:V150 L:L:V206 1004.81NoNo000
118L:L:V150 L:L:Y153 1006.31NoYes1500
119L:L:Y153 L:L:Y184 89.67926.95YesYes1500
120L:L:F154 L:L:Y184 62.77566.19NoYes000
121L:L:F154 L:L:P155 44.839815.89NoYes000
122L:L:P155 L:L:V11 17.9368.84YesNo000
123L:L:P155 L:L:T124 17.9365.25YesNo000
124L:L:P127 L:L:Y153 80.71135.56YesYes1500
125L:L:G126 L:L:P127 17.93594.06NoYes1500
126L:L:H208 L:L:P127 35.87187.63YesYes000
127L:L:H208 L:L:S211 17.9368.37YesNo000
128L:L:V158 L:L:Y153 44.839612.62NoYes000
129L:L:H208 L:L:V158 35.87175.54YesNo000
130L:L:P127 L:L:T213 17.93595.25YesNo1500
131L:L:C148 L:L:V129 17.94213.42NoYes000
132L:L:P131 L:L:V219 1005.3YesNo000
133L:L:G147 L:L:L132 17.93573.42NoYes000
134L:L:L146 L:L:V219 1007.45YesNo000
135L:L:L146 L:L:P134 1006.57YesYes000
136L:L:L197 L:L:P134 1003.28YesYes000
137L:L:A145 N:N:T119 20.17951.68NoNo000
138L:L:A145 L:L:T191 13.4531.68NoNo000
139L:L:L146 L:L:W162 62.7794.56YesYes000
140L:L:L146 L:L:Y202 62.77657.03YesYes000
141L:L:L186 L:L:V150 17.93574.47NoNo1500
142L:L:E156 L:L:Y153 17.935912.35NoYes1500
143L:L:H208 L:L:P210 35.87218.3YesNo000
144L:L:V160 L:L:V206 26.90413.21NoNo000
145L:L:S188 L:L:V160 17.93618.08NoNo000
146L:L:L167 L:L:W162 26.90363.42NoYes3300
147L:L:L167 L:L:N163 17.93585.49NoNo000
148L:L:L197 L:L:P221 89.68053.28YesNo000
149L:L:E220 L:L:P221 80.71253.14NoNo000
150L:L:E220 L:L:K218 71.74459.45NoNo000
151L:L:K218 L:L:T201 62.77654.5NoNo000
152L:L:I203 L:L:T201 53.80853.04NoNo000
153L:L:D216 L:L:I203 44.84041.4NoNo000
154L:L:D216 L:L:N205 35.87249.42NoNo000
155L:L:L178 L:L:Y184 17.93617.58NoYes000
156L:L:S196 L:L:Y202 35.87233.82YesYes3700
157L:L:P193 L:L:S196 17.93623.56NoYes000
158R:R:R274 R:R:T399 1005.17YesNo034
159R:R:P400 R:R:T399 1003.5YesNo094
160R:R:C398 R:R:P400 1003.77NoYes4299
161R:R:C398 R:R:L277 1003.17NoYes099
162R:R:L252 R:R:L277 68.16072.77YesYes099
163R:R:L231 R:R:L252 61.80212.77YesYes1979
164R:R:L231 R:R:V205 58.85712.98YesNo077
165R:R:L182 R:R:V205 57.62874.47NoNo067
166R:R:L180 R:R:L182 18.236.92NoNo076
167R:R:F154 R:R:L180 17.9844.87YesNo067
168R:R:F154 R:R:L128 16.27246.09YesNo069
169R:R:I106 R:R:L128 13.80474.28NoNo079
170R:R:F97 R:R:I106 13.5586.28YesNo097
171R:R:D276 R:R:R255 10021.44NoYes044
172R:R:D276 R:R:T399 10015.9NoNo044
173R:R:F172 R:R:L182 39.15838.53YesNo086
174R:R:F141 R:R:F172 32.5259.65YesYes078
175R:R:F141 R:R:P142 16.036810.11YesYes479
176R:R:I117 R:R:P142 12.353.39NoYes489
177R:R:I117 R:R:L92 12.10824.28NoYes488
178R:R:I67 R:R:P68 15.30193.39YesNo055
179R:R:E93 R:R:P68 14.81354.72NoNo065
180R:R:P168 R:R:Q193 10.37621.58YesNo065
181R:R:H282 R:R:L277 1005.14NoYes099
182R:R:H282 R:R:Y279 1007.62NoYes099
183R:R:I486 R:R:Y279 10012.09NoYes089
184R:R:I486 R:R:S281 1003.1NoNo089
185R:R:A485 R:R:S281 1003.42NoNo099
186R:R:A485 R:R:Y481 1005.34NoYes098
187R:R:Q489 R:R:Y481 1009.02NoYes098
188R:R:N406 R:R:Q489 1007.92NoNo099
189R:R:D403 R:R:N406 1006.73NoNo089
190R:R:D403 R:R:F405 1009.55NoYes088
191R:R:F405 W:W:?1 1006.11YesYes580
192R:R:Y667 W:W:?1 1009.25YesYes590
193R:R:M463 R:R:Y667 1007.18NoYes099
194R:R:M463 R:R:S671 1006.13NoNo099
195R:R:D460 R:R:S671 1004.42YesNo099
196R:R:D460 R:R:N674 1008.08YesYes2499
197R:R:N674 R:R:Y678 1003.49YesYes2499
198R:R:R519 R:R:Y678 1005.14YesYes099
199A:A:Y391 R:R:R519 10020.58YesYes049
200A:A:Y391 R:R:E518 1005.61YesNo049
201R:R:E518 R:R:P449 1006.29NoNo098
202R:R:N447 R:R:P449 10014.66NoNo088
203R:R:N447 R:R:R450 10010.85NoNo089
204R:R:R450 R:R:S442 1006.59NoNo2598
205R:R:S442 R:R:Y444 1003.82NoYes2587
206R:R:D688 R:R:R450 1005.96YesNo2599
207R:R:D688 R:R:Y444 1006.9YesYes2597
208B:B:D312 R:R:Y444 1005.75NoYes057
209R:R:D460 R:R:L456 11.89758.14YesYes2499
210R:R:C600 R:R:T516 15.48535.07NoNo099
211R:R:R519 R:R:Y601 54.31598.23YesYes099
212R:R:L629 R:R:Y678 47.73219.38NoYes2499
213R:R:L629 R:R:Y601 47.52583.52NoYes099
214A:A:L393 R:R:R519 50.14573.64NoYes089
215R:R:C600 R:R:W520 11.22725.22NoYes097
216R:R:T524 R:R:W520 12.04869.7NoYes087
217A:A:F219 A:A:L43 29.45636.09YesNo087
218A:A:I245 A:A:L43 30.85894.28NoNo077
219A:A:I245 A:A:I288 33.65855.89NoYes079
220A:A:D378 A:A:I288 75.71928.4NoYes079
221A:A:D378 A:A:Y360 10017.24NoYes078
222A:A:Y358 A:A:Y360 65.90233.97NoYes048
223A:A:R385 A:A:Y358 67.30336.17NoNo054
224A:A:L394 A:A:R385 1004.86NoNo085
225A:A:L394 R:R:I622 1005.71NoNo088
226R:R:I622 R:R:Y605 1004.84NoYes089
227R:R:M626 R:R:Y605 1004.79NoYes099
228R:R:M626 R:R:Y601 92.3359.58NoYes099
229A:A:D381 A:A:Y360 65.901710.34NoYes088
230A:A:D381 A:A:R385 66.602211.91NoNo085
231A:A:L393 R:R:M626 49.26984.24NoNo089
232B:B:D83 B:B:R68 74.410816.68YesNo085
233B:B:R68 B:B:Y85 10025.72NoNo054
234B:B:Y85 G:G:P60 10011.13NoYes349
235B:B:M325 G:G:P60 1005.03NoYes059
236B:B:M325 G:G:P49 1006.71NoYes057
237G:G:D48 G:G:P49 1003.22YesYes097
238B:B:S279 G:G:D48 98.555310.31NoYes099
239B:B:L284 B:B:S279 99.41874.5YesNo059
240B:B:L284 B:B:V296 1005.96YesNo055
241B:B:L286 B:B:V296 1004.47NoNo075
242B:B:L286 B:B:V327 1004.47NoNo076
243B:B:V327 G:G:L50 1004.47NoNo069
244B:B:M45 G:G:L50 1005.65NoNo049
245B:B:M45 B:B:W339 1003.49NoYes1349
246B:B:T329 B:B:W339 1009.7NoYes089
247B:B:H311 B:B:T329 1006.85YesNo098
248B:B:D333 B:B:H311 1008.82YesYes1399
249B:B:D312 B:B:D333 1006.65NoYes059
250G:G:D48 G:G:L51 98.61688.14YesYes096
251B:B:L284 G:G:L51 1004.15YesYes056
252B:B:K337 B:B:W339 1008.12YesYes1369
253B:B:H311 B:B:K337 10013.1YesYes1396
254A:A:E27 B:B:K89 10.383112.15NoYes369
255B:B:I80 B:B:K89 134.36NoYes389
256B:B:H54 B:B:I80 15.593413.26YesNo398
257B:B:D76 B:B:H54 54.59655.04YesYes399
258A:A:Y37 B:B:D76 83.1313.45YesYes349
259A:A:R42 A:A:Y37 96.103426.75NoYes094
260A:A:F222 A:A:R42 1003.21YesNo079
261A:A:F222 B:B:W99 10021.05YesYes279
262B:B:Q75 B:B:W99 1006.57YesYes299
263B:B:K57 B:B:Q75 67.44313.56YesYes299
264B:B:K57 B:B:W332 70.036416.24YesYes299
265B:B:R314 B:B:W332 10018.99YesYes289
266B:B:R314 B:B:T274 1006.47YesNo288
267B:B:S275 B:B:T274 1004.8NoNo088
268B:B:L318 B:B:S275 1006.01NoNo068
269B:B:C294 B:B:L318 1003.17YesNo056
270B:B:C294 B:B:V315 1005.12YesYes1357
271B:B:H311 B:B:V315 1004.15YesYes1397
272B:B:K89 B:B:W82 13.025110.44YesYes399
273B:B:H54 B:B:W82 20.84293.17YesYes399
274B:B:Q75 B:B:Y59 67.443320.29YesYes298
275B:B:W332 B:B:Y59 10011.58YesYes298
276B:B:C294 B:B:T329 1003.38YesNo058
277B:B:S331 B:B:V315 1003.23NoYes1397
278B:B:D333 B:B:S331 10010.31YesNo1399
279B:B:D76 B:B:K78 23.36288.3YesYes098
280A:A:D33 A:A:Q29 10.38829.14NoNo054
281A:A:D33 B:B:K78 12.98529.68NoYes058
282A:A:R42 A:A:T40 12.99022.59NoNo097
283A:A:C237 A:A:F238 16.86824.19YesYes289
284A:A:C237 B:B:Y59 28.54135.38YesYes288
285A:A:K53 A:A:V247 25.24314.55YesYes1097
286A:A:F290 A:A:V247 50.48535.24YesYes1097
287A:A:F290 A:A:I288 39.26683.77YesYes099
288A:A:F290 A:A:H362 39.26335.66YesNo099
289A:A:D378 A:A:H362 50.479712.61NoNo079
290A:A:K53 A:A:L45 16.82898.46YesNo1098
291A:A:L45 A:A:M221 14.02428.48NoNo1088
292A:A:F246 A:A:I276 1003.77YesYes1498
293A:A:I276 A:A:L282 1004.28YesNo089
294A:A:L282 A:A:N279 1009.61NoNo098
295A:A:N279 A:A:W281 1003.39NoYes085
296A:A:W281 B:B:D290 1008.93YesYes256
297B:B:D290 B:B:T274 1004.34YesNo268
298A:A:W281 B:B:R314 10023.99YesYes258
299A:A:D249 A:A:N50 12.9694.04NoYes2989
300A:A:D249 A:A:K293 25.93815.21NoNo089
301A:A:K293 A:A:S251 33.71923.06NoNo099
302A:A:L297 A:A:S251 36.31294.5YesNo089
303A:A:L297 A:A:Q294 51.87215.32YesYes086
304A:A:F363 A:A:Q294 59.65149.37YesYes2156
305A:A:F363 A:A:L291 1006.09YesNo058
306A:A:L289 A:A:L291 1006.92YesNo098
307A:A:F246 A:A:L289 1004.87YesYes1499
308A:A:D249 A:A:D252 10.37527.98NoNo2988
309A:A:S51 A:A:V247 11.2196.46YesYes1097
310A:A:G52 A:A:N292 11.21893.39NoYes099
311A:A:N292 A:A:V247 11.2194.43YesYes097
312A:A:N292 A:A:T364 11.2197.31YesNo099
313A:A:F290 A:A:T364 14.02356.49YesNo1099
314A:A:C237 B:B:L117 10.38156.35YesYes289
315B:B:M101 B:B:Y145 1007.18YesYes298
316B:B:M101 B:B:Y59 1005.99YesYes298
317A:A:K233 B:B:Y145 10.40343.58YesYes298
318A:A:F246 A:A:F273 46.67734.29YesYes1499
319A:A:F246 A:A:F345 70.01263.22YesYes1498
320A:A:F312 A:A:Q267 59.64575.86YesNo084
321A:A:L270 A:A:Q267 64.83183.99NoNo064
322A:A:F345 A:A:L270 67.422910.96YesNo086
323A:A:L308 A:A:Y253 15.562518.76NoNo078
324A:A:F315 A:A:L308 18.15624.87YesNo067
325A:A:F315 A:A:F340 31.122722.51YesYes067
326A:A:F312 A:A:F340 41.49427.5YesYes3087
327A:A:F273 A:A:W277 20.75115.01YesYes1496
328A:A:C359 A:A:F273 15.5644.19YesYes059
329A:A:C359 A:A:L289 15.5633.17YesYes059
330A:A:N278 A:A:W277 10.37763.39NoYes086
331A:A:C359 A:A:S349 10.37713.44YesNo057
332A:A:F363 A:A:K338 23.34347.44YesNo2155
333A:A:L297 A:A:V301 10.37542.98YesNo087
334A:A:D331 A:A:P332 10.375611.27NoNo041
335A:A:P332 A:A:T335 12.96951.75NoNo014
336A:A:P328 A:A:T335 15.56335.25NoNo014
337A:A:K338 A:A:P328 20.7515.02NoNo051
338A:A:P321 A:A:Y339 12.97044.17NoNo053
339A:A:F363 A:A:Y339 15.56218.25YesNo2153
340A:A:C359 A:A:L346 15.56373.17YesNo054
341B:B:E10 B:B:Q6 13.01842.55YesNo081
342B:B:E10 B:B:L14 16.923610.6YesYes3488
343B:B:L14 G:G:A23 26.03591.58YesNo088
344B:B:I18 G:G:A23 35.14733.25NoNo078
345B:B:I18 B:B:R22 40.33977.52NoNo076
346B:B:Q259 B:B:R22 1008.18NoNo066
347B:B:Q259 G:G:V30 1005.73NoNo068
348B:B:L261 G:G:V30 1004.47NoNo058
349B:B:L261 B:B:L30 1004.15NoNo055
350B:B:L30 B:B:M262 1005.65NoYes054
351B:B:M262 B:B:Y264 1008.38YesYes045
352B:B:W297 B:B:Y264 10017.36NoYes085
353B:B:W297 B:B:Y289 1005.79NoYes287
354B:B:C271 B:B:Y289 1004.03NoYes257
355B:B:C271 B:B:D290 1004.67NoYes256
356B:B:D258 B:B:R22 92.37648.34YesNo076
357B:B:L30 G:G:A34 10.41194.73NoNo056
358B:B:R283 G:G:L51 16.5024.86YesYes096
359G:G:F61 G:G:P60 13.83827.22YesYes389
360B:B:T321 B:B:W63 10.414812.13NoYes377
361B:B:D323 B:B:T321 12.13838.67NoNo377
362B:B:D323 B:B:M325 15.59846.93NoNo075
363B:B:L69 B:B:Y105 1003.52NoYes056
364B:B:D66 B:B:L69 62.30315.43NoNo085
365B:B:D66 B:B:R68 64.033.57NoNo085
366B:B:D83 B:B:L69 62.36914.07YesNo085
367B:B:C148 B:B:T102 88.46913.38YesNo068
368B:B:C149 B:B:T102 91.06363.38NoNo088
369B:B:C121 B:B:C149 46.80513.64YesNo288
370B:B:C121 B:B:T159 48.06633.38YesYes289
371B:B:H142 B:B:T159 51.95986.85YesYes299
372B:B:H142 B:B:S161 10015.34YesNo299
373B:B:G162 B:B:S161 1003.71NoNo299
374B:B:G162 B:B:Y145 10010.14NoYes298
375B:B:C149 B:B:I157 46.85354.91NoYes287
376B:B:I157 B:B:W169 58.46193.52YesYes278
377B:B:H142 B:B:W169 93.50687.41YesYes298
378B:B:I81 B:B:Y105 65.76614.84YesYes3176
379B:B:V71 B:B:Y105 34.61377.57YesYes3186
380B:B:C103 B:B:V71 31.1533.42NoYes088
381B:B:A73 B:B:C103 24.23063.61NoNo098
382B:B:A73 B:B:V100 20.76945.09NoNo099
383B:B:L95 B:B:V100 10.38484.47YesNo3289
384B:B:H91 B:B:I81 62.30547.95NoYes057
385B:B:H91 B:B:V133 55.38284.15NoNo054
386B:B:I93 B:B:V133 51.921510.75NoNo074
387B:B:I93 B:B:Y124 44.9996.04NoYes076
388B:B:E138 B:B:S122 17.30774.31YesNo068
389B:B:S122 B:B:Y124 20.76927.63NoYes086
390B:B:E138 B:B:V135 17.30774.28YesNo064
391B:B:V135 B:B:Y124 20.76927.57NoYes046
392B:B:D118 B:B:I120 13.84624.2NoNo096
393B:B:E138 B:B:I120 20.76936.83YesNo066
394B:B:I123 B:B:Y111 15.63583.63YesYes264
395B:B:I123 B:B:L139 27.29874.28YesNo069
396B:B:L139 B:B:W169 28.565215.94NoYes098
397B:B:I123 B:B:S136 10.42383.1YesNo264
398B:B:C148 B:B:S160 38.97413.44YesYes966
399B:B:C148 B:B:L190 44.17063.17YesYes965
400B:B:L168 B:B:V213 11.71472.98NoNo064
401B:B:R214 B:B:V213 15.61967.85NoNo094
402B:B:E215 B:B:R214 27.33425.82NoNo039
403B:B:D212 B:B:E215 20.82610.39NoNo093
404B:B:D212 B:B:L198 11.71465.43NoNo093
405B:B:L198 B:B:L210 13.01626.92NoYes035
406B:B:L210 B:B:L255 40.34355.54YesNo056
407B:B:F222 B:B:L255 41.64473.65YesNo086
408B:B:D258 B:B:F222 84.58343.58YesYes778
409B:B:D212 B:B:R219 11.714616.68NoNo095
410B:B:L210 B:B:R219 26.03234.86YesNo055
411B:B:E215 B:B:M217 10.41315.41NoNo033
412B:B:M217 B:B:R219 13.01634.96NoNo035
413B:B:F199 B:B:L190 33.77784.87YesYes995
414B:B:S160 B:B:V187 33.77794.85YesYes969
415B:B:F180 B:B:F199 10.393313.93YesYes979
416B:B:F199 B:B:W211 18.188514.03YesYes998
417B:B:H183 B:B:V187 25.98314.15YesYes999
418B:B:D205 B:B:H183 12.9928.82YesYes999
419B:B:F222 B:B:F241 14.314310.72YesYes786
420B:B:F222 B:B:F253 27.33049.65YesYes786
421B:B:K209 B:B:T221 10.393613.51YesNo067
422B:B:L285 B:B:Y264 35.12137.03YesYes065
423B:B:F235 B:B:F278 19.51218.57YesYes1867
424B:B:F278 B:B:L285 29.91648.53YesYes076
425B:B:F235 B:B:N237 10.411612.08YesNo1865
426L:L:F130 L:L:S128 17.93522.64YesNo000
427L:L:L197 L:L:S194 17.93621.5YesNo000
428L:L:N205 L:L:S161 17.93621.49NoNo000
429L:L:K209 L:L:P210 17.93591.67NoNo000
430N:N:F100 N:N:T89 10018.16YesYes100
431L:L:W107 N:N:L46 1005.69YesYes100
432L:L:T106 N:N:T89 91.76974.71NoYes100
433L:L:W111 N:N:Y36 1007.72YesYes100
434L:L:Q39 L:L:Y95 1006.76YesYes100
435L:L:Q39 N:N:Y87 1004.51YesYes100
436N:N:Y49 R:R:Y185 1008.94YesYes107
437N:N:Q53 R:R:N208 1005.28YesYes105
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


2D representation of the interactions of this orthosteric/allosteric ligand.


Links and nodes colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
N:N:N30 R:R:N110 4.09 1 No No 0 6 0 1
N:N:N31 R:R:R109 9.64 1 Yes Yes 0 5 0 1
N:N:Y49 R:R:Y185 8.94 1 Yes Yes 0 7 0 1
N:N:Y50 R:R:E157 5.61 1 Yes Yes 0 8 0 1
N:N:D51 R:R:K209 4.15 0 No Yes 0 7 0 1
N:N:Q53 R:R:N208 5.28 1 Yes Yes 0 5 0 1
N:N:Q53 R:R:K209 10.85 1 Yes Yes 0 7 0 1
N:N:Q53 R:R:Q235 5.12 1 Yes No 0 4 0 1
N:N:L54 R:R:R255 12.15 0 No Yes 0 4 0 1
N:N:S56 R:R:E251 4.31 1 No Yes 0 5 0 1
N:N:S56 R:R:I253 3.1 1 No Yes 0 4 0 1
N:N:S56 R:R:R274 3.95 1 No Yes 0 3 0 1
N:N:D93 R:R:I85 7 1 No No 0 6 0 1
L:L:R28 R:R:K129 9.9 1 Yes Yes 0 5 0 1
L:L:R28 R:R:D151 5.96 1 Yes No 0 4 0 1
L:L:R28 R:R:F153 7.48 1 Yes Yes 0 5 0 1
L:L:S31 R:R:K129 4.59 1 No Yes 0 5 0 1
L:L:Y32 R:R:I155 3.63 1 Yes Yes 0 5 0 1
L:L:D52 R:R:R80 9.53 1 Yes Yes 0 4 0 1
L:L:D52 R:R:H105 6.3 1 Yes Yes 0 7 0 1
L:L:T54 R:R:K129 9.01 1 Yes Yes 0 5 0 1
L:L:D55 R:R:R80 13.1 1 Yes Yes 0 4 0 1
L:L:Y57 R:R:D36 5.75 1 Yes No 0 3 0 1
L:L:Y57 R:R:R38 21.61 1 Yes No 0 4 0 1
L:L:Y57 R:R:T56 7.49 1 Yes No 0 5 0 1
L:L:Y57 R:R:K58 3.58 1 Yes Yes 0 5 0 1
L:L:Y57 R:R:R80 13.38 1 Yes Yes 0 4 0 1
L:L:T58 R:R:E35 8.47 36 No No 0 1 0 1
L:L:Y60 R:R:E35 3.37 36 Yes No 0 1 0 1
L:L:K65 R:R:E34 12.15 0 No No 0 4 0 1
L:L:E100 R:R:K183 4.05 1 Yes Yes 0 6 0 1
L:L:P101 R:R:F130 8.67 1 No Yes 0 6 0 1
L:L:P101 R:R:I155 5.08 1 No Yes 0 5 0 1
L:L:G102 R:R:E107 4.91 0 No Yes 0 6 0 1
L:L:Y103 R:R:K58 9.55 1 Yes Yes 0 5 0 1
L:L:Y103 R:R:Y82 14.89 1 Yes Yes 0 4 0 1
L:L:Y103 R:R:E107 3.37 1 Yes Yes 0 6 0 1
L:L:S104 R:R:R109 13.18 1 No Yes 0 5 0 1
L:L:W107 R:R:Y185 5.79 1 Yes Yes 0 7 0 1
R:R:D36 R:R:R38 15.48 1 No No 3 4 1 1
R:R:D36 R:R:Q55 3.92 1 No No 3 4 1 2
R:R:K58 R:R:T40 7.51 1 Yes No 5 8 1 2
R:R:R80 R:R:T56 9.06 1 Yes No 4 5 1 1
R:R:K58 R:R:Y82 5.97 1 Yes Yes 5 4 1 1
R:R:R80 R:R:Y82 15.43 1 Yes Yes 4 4 1 1
R:R:H105 R:R:R80 15.8 1 Yes Yes 7 4 1 1
R:R:H105 R:R:Y82 5.44 1 Yes Yes 7 4 1 1
R:R:E107 R:R:Y82 7.86 1 Yes Yes 6 4 1 1
R:R:I85 R:R:S84 7.74 0 No No 6 7 1 2
R:R:H105 R:R:T104 8.21 1 Yes No 7 5 1 2
R:R:H105 R:R:K129 5.24 1 Yes Yes 7 5 1 1
R:R:F130 R:R:H105 5.66 1 Yes Yes 6 7 1 1
R:R:E107 R:R:R109 8.14 1 Yes Yes 6 5 1 1
R:R:E107 R:R:F130 5.83 1 Yes Yes 6 6 1 1
R:R:E107 R:R:F134 8.16 1 Yes Yes 6 5 1 2
R:R:N110 R:R:R109 10.85 0 No Yes 6 5 1 1
R:R:F134 R:R:R109 11.76 1 Yes Yes 5 5 2 1
R:R:N110 R:R:N135 8.17 0 No No 6 8 1 2
R:R:D151 R:R:K129 13.83 1 No Yes 4 5 1 1
R:R:F130 R:R:I155 3.77 1 Yes Yes 6 5 1 1
R:R:E157 R:R:F130 4.66 1 Yes Yes 8 6 1 1
R:R:E157 R:R:F134 16.32 1 Yes Yes 8 5 1 2
R:R:F134 R:R:T159 6.49 1 Yes Yes 5 5 2 2
R:R:F153 R:R:I155 5.02 0 Yes Yes 5 5 1 1
R:R:F153 R:R:T179 3.89 0 Yes No 5 5 1 2
R:R:F153 R:R:T181 7.78 0 Yes No 5 7 1 2
R:R:E157 R:R:T159 8.47 1 Yes Yes 8 5 1 2
R:R:E157 R:R:K183 13.5 1 Yes Yes 8 6 1 1
R:R:T159 R:R:Y185 6.24 1 Yes Yes 5 7 2 1
R:R:K183 R:R:Y185 4.78 1 Yes Yes 6 7 1 1
R:R:K183 R:R:Y206 3.58 1 Yes Yes 6 6 1 2
R:R:Y185 R:R:Y206 13.9 1 Yes Yes 7 6 1 2
R:R:N208 R:R:Y185 9.3 1 Yes Yes 5 7 1 1
R:R:K209 R:R:N186 19.58 1 Yes No 7 7 1 2
R:R:L230 R:R:Y206 8.21 1 No Yes 4 6 2 2
R:R:D232 R:R:Y206 6.9 1 Yes Yes 9 6 2 2
R:R:D232 R:R:N208 16.16 1 Yes Yes 9 5 2 1
R:R:N208 R:R:S234 5.96 1 Yes Yes 5 9 1 2
R:R:K209 R:R:Q235 4.07 1 Yes No 7 4 1 1
R:R:E251 R:R:L230 13.25 1 Yes No 5 4 1 2
R:R:D232 R:R:S234 7.36 1 Yes Yes 9 9 2 2
R:R:D232 R:R:I253 15.39 1 Yes Yes 9 4 2 1
R:R:I253 R:R:S234 3.1 1 Yes Yes 4 9 1 2
R:R:R255 R:R:S234 3.95 0 Yes Yes 4 9 1 2
R:R:E251 R:R:I253 8.2 1 Yes Yes 5 4 1 1
R:R:E251 R:R:R274 3.49 1 Yes Yes 5 3 1 1
R:R:D276 R:R:R255 21.44 0 No Yes 4 4 2 1
R:R:R274 R:R:T399 5.17 1 Yes No 3 4 1 2
R:R:D276 R:R:T399 15.9 0 No No 4 4 2 2
R:R:E61 R:R:I85 2.73 0 No No 5 6 2 1
R:R:R274 R:R:T273 2.59 1 Yes No 3 4 1 2
N:N:G57 R:R:R255 1.5 0 No Yes 0 4 0 1
R:R:D151 R:R:I152 1.4 1 No No 4 3 1 2

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

ShowSimilarityNetwork TypeNameLigandDescription
100.00Single6D32Cyclopamine6D32-SMO-Cyclopamine-Cyclopamine
100.00Single6D35Cholesterol6D35-SMO-Cholesterol
100.00Single6N51Quisqualate6N51-mGlu5; mGlu5-Quisqualate
100.00Single6N51Quisqualate6N51-mGlu5; mGlu5-Quisqualate
100.00Single6UO8SKF975416UO8-GABAB1, GABAB2-SKF97541-GS39783
100.00Single6UO9SKF975416UO9-GABAB1, GABAB2-SKF97541
100.00Single6W2XPubChem 53110426W2X-GABAB1, GABAB2-PubChem 5311042-PubChem 23727970
100.00Single6W2YPubChem 53110426W2Y-GABAB1; GABAB1-PubChem 5311042-PubChem 23727970
100.00Single6W2YPubChem 53110426W2Y-GABAB1; GABAB1-PubChem 5311042-PubChem 23727970
100.00Single7C7QBaclofen7C7Q-GABAB1, GABAB2-Baclofen-PubChem 7023848
100.00Single7C7SCGP546267C7S-GABAB1, GABAB2-CGP54626
100.00Single7CUMCGP546267CUM-GABAB1, GABAB2-CGP54626-Phospholipid
100.00Single7DD5Ca7DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
100.00Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
100.00Single7DD5Ca7DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
100.00Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
100.00Single7DGEQuisqualate7DGE-mGlu1; mGlu1-Quisqualate
100.00Single7DTTCa7DTT-CaS-Ca-Ca
100.00Single7DTTCa7DTT-CaS-Ca-Ca
100.00Single7DTUTryptophan7DTU-CaS-Tryptophan
100.00Single7DTUTryptophan7DTU-CaS-Tryptophan
100.00Single7DTVCa7DTV-CaS-Ca-Ca; Tryptophan
100.00Single7DTVCa; Tryptophan7DTV-CaS-Ca-Ca; Tryptophan
100.00Single7DTVCa7DTV-CaS-Ca-Ca; Tryptophan
100.00Single7DTVCa; Tryptophan7DTV-CaS-Ca-Ca; Tryptophan
100.00Single7E6TCa7E6T-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
100.00Single7E6TCa; Ca; Cyclomethyltryptophan; PO47E6T-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
100.00Single7E6TCa7E6T-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
100.00Single7E6TCa; Ca; Cyclomethyltryptophan; PO47E6T-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
100.00Single7E9GEglumetad7E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/β1/γ2
100.00Single7E9GEglumetad7E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/β1/γ2
100.00Single7E9HPhosphoserine7E9H-mGlu4; mGlu4-Phosphoserine-Gi3/β1/γ2
100.00Single7E9HPhosphoserine7E9H-mGlu4; mGlu4-Phosphoserine-Gi3/β1/γ2
100.00Single7EB2Baclofen7EB2-GABAB2; GABAB1-Baclofen-rac-BHFF-Gi1/β1/γ2
100.00Single7EPBEglumetad7EPB-mGlu2; mGlu2-Eglumetad
100.00Single7EPBEglumetad7EPB-mGlu2; mGlu2-Eglumetad
100.00Single7FD8Quisqualate7FD8-mGlu5; mGlu5-Quisqualate
100.00Single7FD8Quisqualate7FD8-mGlu5; mGlu5-Quisqualate
100.00Single7FD9LY3414957FD9-mGlu5; mGlu5-LY341495
100.00Single7FD9LY3414957FD9-mGlu5; mGlu5-LY341495
100.00Single7FIHhCG7FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/β1/γ2
100.00Single7FIIhCG7FII-LH-hCG-chim(NtGi1-Gs)/β1/γ2
100.00Single7M3ECa; Ca; Tryptophan; NPS-21437M3E-CaS-Ca; Ca; Tryptophan; NPS-2143
100.00Single7M3ECa; Ca; Tryptophan; NPS-21437M3E-CaS-Ca; Ca; Tryptophan; NPS-2143
100.00Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
100.00Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
100.00Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
100.00Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
100.00Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
100.00Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
100.00Single7MTQLY3414957MTQ-mGlu2; mGlu2-LY341495
100.00Single7MTQLY3414957MTQ-mGlu2; mGlu2-LY341495
100.00Single7MTRGlutamate7MTR-mGlu2; mGlu2-Glutamate-ADX55164
100.00Single7MTRGlutamate7MTR-mGlu2; mGlu2-Glutamate-ADX55164
100.00Single7MTSGlutamate7MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/β1/γ2
100.00Single7MTSGlutamate7MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/β1/γ2
100.00Single7SILCa7SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
100.00Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
100.00Single7SILCa7SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
100.00Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
100.00Single7SIMCa7SIM-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
100.00Single7SIMCa; Ca; Cyclomethyltryptophan; PO47SIM-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
100.00Single7SIMCa7SIM-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
100.00Single7SIMCa; Ca; Cyclomethyltryptophan; PO47SIM-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
100.00Single7WI6LY3414957WI6-mGlu3; mGlu3-LY341495
100.00Single7WI6LY3414957WI6-mGlu3; mGlu3-LY341495
100.00Single7WI8LY3414957WI8-mGlu3; mGlu3-LY341495
100.00Single7WI8LY3414957WI8-mGlu3; mGlu3-LY341495
100.00Single7WIHLY27941937WIH-mGlu3; mGlu3-LY2794193
100.00Single7WIHLY27941937WIH-mGlu3; mGlu3-LY2794193
100.00Single7XW6M22 Fab7XW6-TSH-M22 Fab-ML109-Gs/β1/γ2
100.00Single7XW7K1-707XW7-TSH-K1-70
100.00Single8JCULY3414958JCU-mGlu2; mGlu3-LY341495
100.00Single8JCULY3414958JCU-mGlu2; mGlu3-LY341495
100.00Single8JCVLY3414958JCV-mGlu2; mGlu3-LY341495
100.00Single8JCVLY3414958JCV-mGlu2; mGlu3-LY341495
100.00Single8JCWLY3414958JCW-mGlu2; mGlu3-LY341495
100.00Single8JCWLY3414958JCW-mGlu2; mGlu3-LY341495
100.00Single8JCXLY3414958JCX-mGlu2; mGlu3-LY341495
100.00Single8JCXLY3414958JCX-mGlu2; mGlu3-LY341495
100.00Single8JCYLY3414958JCY-mGlu2; mGlu3-LY341495
100.00Single8JCYLY3414958JCY-mGlu2; mGlu3-LY341495
100.00Single8JCZLY3414958JCZ-mGlu2; mGlu3-LY341495
100.00Single8JCZLY3414958JCZ-mGlu2; mGlu3-LY341495
100.00Single8JD0Glutamate8JD0-mGlu2; mGlu3-Glutamate-NAM563
100.00Single8JD1Glutamate8JD1-mGlu2; mGlu3-Glutamate
100.00Single8JD1Glutamate8JD1-mGlu2; mGlu3-Glutamate
100.00Single8JD2Glutamate8JD2-mGlu2; mGlu3-Glutamate
100.00Single8JD2Glutamate8JD2-mGlu2; mGlu3-Glutamate
100.00Single8JD3Glutamate8JD3-mGlu2; mGlu3-Glutamate-HZR; PEF-Gi1/β1/γ2
100.00Single8JD3Glutamate8JD3-mGlu2; mGlu3-Glutamate-HZR; PEF-Gi1/β1/γ2
100.00Single8JD4Glutamate8JD4-mGlu2; mGlu4-Glutamate
100.00Single8JD4Glutamate8JD4-mGlu2; mGlu4-Glutamate
100.00Single8JD5Glutamate8JD5-mGlu2; mGlu4-Glutamate-BQI; HZE; PEF-Gi1/β1/γ2
100.00Single8JD5Glutamate8JD5-mGlu2; mGlu4-Glutamate-BQI; HZE; PEF-Gi1/β1/γ2
100.00Single8JD6Phosphoserine8JD6-mGlu4; mGlu4-Phosphoserine-N-(3-chlorophenyl)pyridine-2-carboxamide-Gi3/β1/γ2
100.00Single8JD6Phosphoserine8JD6-mGlu4; mGlu4-Phosphoserine-N-(3-chlorophenyl)pyridine-2-carboxamide-Gi3/β1/γ2
100.00Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
100.00Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
100.00Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
100.00Single8SZGCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-chim(NtGi1-Gq)/β1/γ2
100.00Single8SZGCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-chim(NtGi1-Gq)/β1/γ2
100.00Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/β1/γ2
100.00Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/β1/γ2
100.00Single8SZICa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZI-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi3/β1/γ2
100.00Single8SZICa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZI-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi3/β1/γ2
100.00Single8T7HQuisqualate8T7H-mGlu5; mGlu5-Quisqualate
100.00Single8T7HQuisqualate8T7H-mGlu5; mGlu5-Quisqualate
100.00Single8T8MQuisqualate8T8M-mGlu5; mGlu5-Quisqualate
100.00Single8T8MQuisqualate8T8M-mGlu5; mGlu5-Quisqualate
100.00Single8TAOQuisqualate8TAO-mGlu5; mGlu5-Quisqualate-CDPPB
100.00Single8TAOQuisqualate8TAO-mGlu5; mGlu5-Quisqualate-CDPPB
100.00Single8TQBCa; PAM VU60233268TQB-mGlu3; mGlu3-Ca; PAM VU6023326-Ca
100.00Single8TQBCa; PAM VU60233268TQB-mGlu3; mGlu3-Ca; PAM VU6023326-Ca
100.00Single8TR0LY3414958TR0-mGlu3; mGlu3-LY341495
100.00Single8TR0LY3414958TR0-mGlu3; mGlu3-LY341495
100.00Single8TR2Ca; LY3792688TR2-mGlu3; mGlu3-Ca; LY379268-Ca
100.00Single8TR2Ca; LY3792688TR2-mGlu3; mGlu3-Ca; LY379268-Ca
100.00Single8TRCLY3414958TRC-mGlu3; mGlu3-LY341495
100.00Single8TRCLY3414958TRC-mGlu3; mGlu3-LY341495
100.00Single8TRDLY3414958TRD-mGlu3; mGlu3-LY341495
100.00Single8TRDLY3414958TRD-mGlu3; mGlu3-LY341495
100.00Single8WG9(2S)-2-amino-4-phosphonobutanoic acid8WG9-mGlu4; mGlu2-(2S)-2-amino-4-phosphonobutanoic acid
100.00Single8WGBGlutammate8WGB-mGlu4; mGlu2-Glutammate-W9R-Gi3/β1/γ2
100.00Single8WGBGlutammate8WGB-mGlu4; mGlu2-Glutammate-W9R-Gi3/β1/γ2
100.00Single8WGCLY3792688WGC-mGlu4; mGlu2-LY379268
100.00Single8WGDWAG/WA68WGD-mGlu4; mGlu2-WAG/WA6
100.00Single8WGDWAG/WA68WGD-mGlu4; mGlu2-WAG/WA6
100.00Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
100.00Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
100.00Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/β1/γ2
100.00Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/β1/γ2
100.00Single8WVXNorrin8WVX-LGR4-Norrin
100.00Single8WVYNorrin8WVY-LGR4-Norrin
100.00Single8X0BQuisqualate8X0B-mGlu5; mGlu5-Quisqualate-VU0424465
100.00Single8X0BQuisqualate8X0B-mGlu5; mGlu5-Quisqualate-VU0424465
100.00Single8X0CQuisqualate8X0C-mGlu5; mGlu5-Quisqualate-VU0424465
100.00Single8X0CQuisqualate8X0C-mGlu5; mGlu5-Quisqualate-VU0424465
100.00Single8X0DQuisqualate8X0D-mGlu5; mGlu5-Quisqualate-VU0424465
100.00Single8X0DQuisqualate8X0D-mGlu5; mGlu5-Quisqualate-VU0424465
100.00Single8X0EQuisqualate8X0E-mGlu5; mGlu5-Quisqualate
100.00Single8X0EQuisqualate8X0E-mGlu5; mGlu5-Quisqualate
100.00Single8X0FQuisqualate8X0F-mGlu5; mGlu5-Quisqualate-VU0424465
100.00Single8X0FQuisqualate8X0F-mGlu5; mGlu5-Quisqualate-VU0424465
100.00Single8X0GQuisqualate8X0G-mGlu5; mGlu5-Quisqualate
100.00Single8X0GQuisqualate8X0G-mGlu5; mGlu5-Quisqualate
100.00Single8X0HQuisqualate8X0H-mGlu5; mGlu5-Quisqualate
100.00Single8X0HQuisqualate8X0H-mGlu5; mGlu5-Quisqualate
100.00Single8XUMR-spondin-28XUM-LGR4-R-spondin-2
100.00Single9ASBCa9ASB-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
100.00Single9ASBCa; Ca; Cyclomethyltryptophan; 9IG; PO49ASB-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
100.00Single9AVGCa9AVG-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs)/β1/γ2
100.00Single9AVGCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVG-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs)/β1/γ2
100.00Single9AVLCa9AVL-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi3/β2/γ2
100.00Single9AVLCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVL-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi3/β2/γ2
100.00Single9AVLCa9AVL-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi3/β2/γ2
100.00Single9AVLCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVL-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi3/β2/γ2
100.00Single9AXFCa9AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
100.00Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
100.00Single9AXFCa9AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
100.00Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
100.00Single9AYFCa9AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/β1/γ2
100.00Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/β1/γ2
100.00Single9C1PCa9C1P-CaS-Ca-Ca; Tryptophan; '6218; PO4
100.00Single9C1PCa; Tryptophan; '6218; PO49C1P-CaS-Ca-Ca; Tryptophan; '6218; PO4
100.00Single9C1PCa9C1P-CaS-Ca-Ca; Tryptophan; '6218; PO4
100.00Single9C1PCa; Tryptophan; '6218; PO49C1P-CaS-Ca-Ca; Tryptophan; '6218; PO4
100.00Single9C2FCa9C2F-CaS-Ca-Ca; Ca; Tryptophan; '6218; PO4
100.00Single9C2FCa; Ca; Tryptophan; '6218; PO49C2F-CaS-Ca-Ca; Ca; Tryptophan; '6218; PO4
100.00Single9C2FCa9C2F-CaS-Ca-Ca; Ca; Tryptophan; '6218; PO4
100.00Single9C2FCa; Ca; Tryptophan; '6218; PO49C2F-CaS-Ca-Ca; Ca; Tryptophan; '6218; PO4
100.00Single9II2Glutamate9II2-mGlu3; mGlu3-Glutamate-Arrestin2
100.00Single9II2Glutamate9II2-mGlu3; mGlu3-Glutamate-Arrestin2
100.00Single9II3Glutamate9II3-mGlu3; mGlu3-Glutamate-Arrestin2
100.00Single9II3Glutamate9II3-mGlu3; mGlu3-Glutamate-Arrestin2
50.00Single7DD6Ca7DD6-CaS-Ca-Ca; Ca; Tryptophan
50.00Single7DD6Ca; Ca; Tryptophan7DD6-CaS-Ca-Ca; Ca; Tryptophan
50.00Single7DD6Ca7DD6-CaS-Ca-Ca; Ca; Tryptophan
50.00Single7DD6Ca; Ca; Tryptophan7DD6-CaS-Ca-Ca; Ca; Tryptophan
50.00Single7DD7Ca7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
50.00Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
50.00Single7DD7Ca7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
50.00Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
50.00Single9ASBCa9ASB-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
50.00Single9ASBCa; Ca; Cyclomethyltryptophan; 9IG; PO49ASB-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
50.00Single9AVGCa9AVG-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs)/β1/γ2
50.00Single9AVGCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVG-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs)/β1/γ2
50.00Single9AYFCa9AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/β1/γ2
50.00Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/β1/γ2
33.33Single7KNUCalcitonin gene-related peptide-17KNU-CT Like-Calcitonin gene-related peptide-1-RAMP1
33.33Single7T9MCS-17 Antibody7T9M-TSH-CS-17 Antibody
25.00Single6O3CCholesterol6O3C-SMO-SAG21k-Cholesterol
25.00Single7FIGhCG7FIG-LH-hCG-chim(NtGi1L-Gs)/β1/γ2
25.00Single7UTZTR14027UTZ-TSH-TR1402-PubChem 644078-Gs/β1/γ2
25.00Single7XW5TSH7XW5-TSH-TSH-ML109-Gs/β1/γ2
25.00Single7ZI0Cholesterol7ZI0-SMO-SAG-Cholesterol
20.00Single5L7DCholesterol5L7D-SMO-Cholesterol
20.00Single7T9ITSH7T9I-TSH-TSH-Gs/β1/γ2
20.00Single8HS2Fab0468HS2-GPR20-Fab046
20.00Single8I2GGlycoprotein hormones alpha chain8I2G-FSH-Glycoprotein hormones α chain-Compound 716340-Gs/β1/γ2
20.00Single8X9S5alpha-DHT8X9S-ADGRD1-5α-DHT-chim(NtGi1-Gs)/β1/γ2
20.00Single9IV25alpha-DHT9IV2-ADGRD1-5α-DHT-chim(NtGi1-Gs)/β1/γ2
16.67Single6XBM25(S)-Epoxycholesterol6XBM-SMO-25(S)-Epoxycholesterol-Gi1/β1/γ2
16.67Single8U4QREGN7663-Fab8U4Q-CXCR4-REGN7663-Fab-Cholesterol-Gi1/β1/γ2
16.67Consensusp2y_offOrthosteric Ligandp2y1_off
14.29Single4XNWMRS25004XNW-P2Y1-MRS2500
14.29Single6D32Cyclopamine6D32-SMO-Cyclopamine-Cyclopamine
14.29Single8JEF(3S)-3-hydroxyoctanoic acid8JEF-HCA3-(3S)-3-hydroxyoctanoic acid-Gi1/β1/γ2
14.29Single8JPSCCL78JPS-ACKR1-CCL7
14.29Single8JRVGlucagon8JRV-Glucagon-Glucagon-Arrestin2
14.29Consensusp2y1_offOrthosteric Ligand4XNW-P2Y1-MRS2500
12.50Single4O9RCyclopamine4O9R-SMO-Cyclopamine
12.50Single6LI0C176LI0-GPR52-C17
12.50Single7VDHC48/807VDH-MRGPRX2-C48/80-Gi1/β1/γ2
12.50Single8HSCFab0468HSC-GPR20-Fab046-Gi1/β1/γ2
12.50Single8U4RREGN7663-Fab8U4R-CXCR4-REGN7663-Fab-Cholesterol
12.50Single9B9Y7DY9B9Y-CB1-7DY
11.11Single3V2WPubChem 518926453V2W-S1P1-PubChem 51892645
11.11Single4BWBNeurotensin4BWB-NTS1-Neurotensin
11.11Single4QINSAG1.54QIN-SMO-SAG1.5
11.11Single5U09Taranabant5U09-CB1-Taranabant
11.11Single6LFOInterleukin-86LFO-CXCR2-Interleukin-8-Gi1/β1/γ2
11.11Single6O3CSAG21k6O3C-SMO-SAG21k-Cholesterol
11.11Single6WWZCCL206WWZ-CCR6-CCL20-Go/β1/γ2
11.11Single7BR3Elagolix7BR3-GnRH1-Elagolix
11.11Single7LCJDanuglipron7LCJ-GLP-1-Danuglipron
11.11Single7VIHCBP-3077VIH-S1P1-CBP-307-Gi1/β1/γ2
11.11Single7VV5C48/807VV5-MRGPRX2-C48/80-Gi1/β1/γ2
11.11Single7WF7S1P7WF7-S1P1-S1P-Gi1/β1/γ2
11.11Single8HMPC178HMP-GPR52-C17-Gs/β1/γ2
11.11Single8U4SREGN7663-Fab8U4S-CXCR4-REGN7663-Fab
11.11Single8U4TREGN7663-Fab8U4T-CXCR4-REGN7663-Fab
11.11Single8XXXCXCL68XXX-CXCR2-CXCL6-Go/β1/γ2
11.11Single9BA0A1AKN9BA0-CB1-A1AKN
11.11Consensusccr6_onOrthosteric Ligand6WWZ-CCR6-CCL20-Go/β1/γ2
11.11Consensusccr6_on_gpOrthosteric Ligand6WWZ-CCR6-CCL20-Go/β1/γ2
11.11Consensuscxcr1_onOrthosteric Ligand8IC0-CXCR1-Interleukin-8-Gi1/β1/γ2
11.11Consensusgnrh1_offOrthosteric Ligand7BR3-GnRH1-Elagolix
11.11Consensusp2y1_onOrthosteric Ligand7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/β1/γ2
11.11Consensuss1p1_offOrthosteric Ligand3V2W-S1P1-PubChem 51892645
10.00Single3V2YPubChem 518926453V2Y-S1P1-PubChem 51892645
10.00Single6XBLSAG6XBL-SMO-SAG-Cholesterol-Gi1/β1/γ2
10.00Single7C2EPubChem 1490507997C2E-GLP-1-PubChem 149050799-Gs/β1/γ2
10.00Single7UTZPubChem 6440787UTZ-TSH-TR1402-PubChem 644078-Gs/β1/γ2
10.00Single7VV6C48/807VV6-MRGPRX2-C48/80
10.00Single7XXH2MeSADP7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/β1/γ2
10.00Single7ZI0SAG7ZI0-SMO-SAG-Cholesterol
10.00Single8H4LDoconexent8H4L-FFA4-Doconexent-chim(NtGi1-Gs-CtGq)/β1/γ2
10.00Consensuscb1_offOrthosteric Ligand5U09-CB1-Taranabant 5TGZ-CB1-AM6538
10.00Consensuscxcr2_onOrthosteric Ligand6LFM-CXCR2-Interleukin-8-Gi1/β1/γ2
10.00Consensusgrh_offOrthosteric Ligandgnrh1_off
10.00Consensusnucleotide_offOrthosteric Ligandadenosine_off p2y_off
10.00Consensusp2y1_on_gpOrthosteric Ligand7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/β1/γ2
9.09Single4QIMANTA XV4QIM-SMO-ANTA XV
9.09Single5T04Neurotensin5T04-NTS1-Neurotensin
9.09Single5TGZAM65385TGZ-CB1-AM6538
9.09Single6D27CAY104716D27-DP2-CAY10471
9.09Single6X1ADanuglipron6X1A-GLP-1-Danuglipron-Gs/β1/γ2
9.09Single6XBM25(S)-Epoxycholesterol6XBM-SMO-25(S)-Epoxycholesterol-Gi1/β1/γ2
9.09Single6Z4VNTS8-136Z4V-NTS1-NTS8-13
9.09Single7FIHOrg435537FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/β1/γ2
9.09Single7LCIDanuglipron7LCI-GLP-1-Danuglipron-Gs/β1/γ2
9.09Single7LCKDanuglipron7LCK-GLP-1-Danuglipron
9.09Single7S15PubChem 1346112237S15-GLP-1-PubChem 134611223
9.09Single7SK8CXCL127SK8-ACKR3-CXCL12-CCX662
9.09Single7VIES1P7VIE-S1P1-S1P-Gi1/β1/γ2
9.09Single7VIFS-FTY720-P7VIF-S1P1-S-FTY720-P-Gi1/β1/γ2
9.09Single7YU4ONO-07405567YU4-LPA1-ONO-0740556
9.09Single7YXAONO-54306087YXA-S1P5-ONO-5430608
9.09Single8IC0Interleukin-88IC0-CXCR1-Interleukin-8-Gi1/β1/γ2
9.09Single9B9ZA1AKO9B9Z-CB1-A1AKO
9.09Single9IVGGLP-1 (Truncated)9IVG-GLP-1-GLP-1 (Truncated)-chim(NtGi1-Gs)/β1/γ2
9.09Consensuscxcr1_on_gpOrthosteric Ligand8IC0-CXCR1-Interleukin-8-Gi1/β1/γ2
9.09Consensuslipid_offOrthosteric Ligandcannabinoid_off paf_off lpl_off prostanoid_off leukotriene_off
9.09Consensusnucleotide_offonOrthosteric Ligandnucleotide_off nucleotide_on
9.09Consensusnucleotide_offon_gpOrthosteric Ligandnucleotide_on_gp nucleotide_off
8.33Single4JKVTaladegib4JKV-SMO-Taladegib
8.33Single5C1MBU725C1M-μ-BU72
8.33Single6LFMInterleukin-86LFM-CXCR2-Interleukin-8-Gi1/β1/γ2
8.33Single6XBKCholesterol6XBK-SMO-Cholesterol-Gi1/β1/γ2
8.33Single7BB7AVP7BB7-V2-AVP-Gs/β1/γ2
8.33Single7C4SS1P7C4S-S1P3-S1P
8.33Single7EO2FTY720-P7EO2-S1P1-FTY720-P-Gi1/β1/γ2
8.33Single7TD3S1P7TD3-S1P1-S1P-Gi1/β1/γ2
8.33Single7YU3ONO-07405567YU3-LPA1-ONO-0740556-Gi1/β1/γ2
8.33Single7YU6ONO-07405567YU6-LPA1-ONO-0740556-Gi1/β1/γ2
8.33Single8ID4Linoleic acid8ID4-FFA4-Linoleic acid-Gi1/β1/γ2
8.33Single8ZPTPrRP208ZPT-PrRP-PrRP20-chim(NtGi1-Gs-CtGq)/β1/γ2
8.33Consensuscxcr2_on_gpOrthosteric Ligand6LFM-CXCR2-Interleukin-8-Gi1/β1/γ2
8.33Consensuslpa1_onOrthosteric Ligand7TD1-LPA1-LPA-Gi1/β1/γ2 7YU3-LPA1-ONO-0740556-Gi1/β1/γ2
8.33Consensuslpa1_on_gpOrthosteric Ligand7TD1-LPA1-LPA-Gi1/β1/γ2 7YU3-LPA1-ONO-0740556-Gi1/β1/γ2
8.33Consensuss1p5_offOrthosteric Ligand7YXA-S1P5-ONO-5430608
8.33Consensuss1p_offOrthosteric Ligands1p1_off s1p5_off
7.69Single3ZEVNeurotensin3ZEV-NTS1-Neurotensin
7.69Single4BV0Neurotensin4BV0-NTS1-Neurotensin
7.69Single4Z34ONO-97803074Z34-LPA1-ONO-9780307
7.69Single5V56TC1145V56-SMO-TC114
7.69Single5V57TC1145V57-SMO-TC114
7.69Single6OS1TRV0266OS1-AT1-TRV026
7.69Single7EW1Siponimod7EW1-S1P5-Siponimod-Gi1/β1/γ2
7.69Single7EW3S1P7EW3-S1P3-S1P-Gi1/β1/γ2
7.69Single7F1TMIP-1a7F1T-CCR5-MIP-1a
7.69Single7F58THIQ7F58-MC4-THIQ-Gs/β1/γ2
7.69Single7L0PNeurotensin7L0P-NTS1-Neurotensin-Gi1/β1/γ1
7.69Single7L0QNeurotensin7L0Q-NTS1-Neurotensin-Gi1/β1/γ1
7.69Single7R0CAVP7R0C-V2-AVP-Arrestin2
7.69Single7SK7CXCL127SK7-ACKR3-CXCL12-CCX662
7.69Single7T9NPubChem 6440787T9N-TSH-M22 Fab-PubChem 644078-Gs/β1/γ2
7.69Single7TD1LPA7TD1-LPA1-LPA-Gi1/β1/γ2
7.69Single7VIGCBP-3077VIG-S1P1-CBP-307-Gi1/β1/γ2
7.69Single7YU5ONO-07405567YU5-LPA1-ONO-0740556-Gi1/β1/γ2
7.69Single7YU7ONO-07405567YU7-LPA1-ONO-0740556-Gi1/β1/γ2
7.69Single8E0GBU728E0G-μ-BU72
7.69Single8FMZNeurotensin/Neuromedin-N8FMZ-NTS1-Neurotensin/Neuromedin-N-chim(NtGi2L-Gs-CtGq)/β1/γ2
7.69Single8FN1Neurotensin/Neuromedin-N8FN1-NTS1-Neurotensin/Neuromedin-N-chim(NtGi1-Go)/β1/γ2
7.69Single8HQCC5a anaphylatoxin8HQC-C5a1-C5a anaphylatoxin-Go/β1/γ2
7.69Single8I2GCompound 7163408I2G-FSH-Glycoprotein hormones α chain-Compound 716340-Gs/β1/γ2
7.69Single8ID39-Hydroxystearic acid8ID3-FFA4-9-Hydroxystearic acid-Gi1/β1/γ2
7.69Single8ID6Oleic acid8ID6-FFA4-Oleic acid-Gi1/β1/γ2
7.69Single8JBGNeurokinin-B8JBG-NK3-Neurokinin-B-chim(NtGi1-Gs-CtGq)/β1/γ2
7.69Single8JZPC5A anaphylatoxin8JZP-C5a1-C5A anaphylatoxin-Go/β1/γ2
7.69Single8WJXADP8WJX-P2Y1-ADP-chim(Gs-CtGq)/β1/γ2
7.69Single8XX7CXCL58XX7-CXCR2-CXCL5-Go/β1/γ2
7.69Single9ASTLymphotactin9AST-XCR1-Lymphotactin-Gi1/β1/γ2
7.69Single9IZGNKP9IZG-LPA1-NKP-chim(NtGi1-Gs-CtGq)/β1/γ2
7.69Consensusclass-a_offOrthosteric Ligandsensory_off alicarboxylic_off amine_off lipid_off nucleotide_off peptide_off protein_off
7.69Consensusgi_lpaOrthosteric Ligand7TD1-LPA1-LPA-Gi1/β1/γ2 7YU3-LPA1-ONO-0740556-Gi1/β1/γ2
7.69Consensuslpa_onOrthosteric Ligandlpa1_on
7.69Consensuslpa_on_gpOrthosteric Ligandlpa1_on_gp
7.69Consensusmotilin_onOrthosteric Ligand8IBU-Motilin-Erythromycin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
7.69Consensusneurotensin_onOrthosteric Ligandnts1_on
7.69Consensusnts1_onOrthosteric Ligand6OSA-NTS1-JMV449-Gi1/β1/γ2 7L0S-NTS1-Neurotensin-Gi1/β1/γ1
7.69Consensusprotein_offOrthosteric Ligandchemokine_off grh_off
7.69Consensuss1p5_onOrthosteric Ligand7EW1-S1P5-Siponimod-Gi1/β1/γ2
7.69Consensuss1p5_on_gpOrthosteric Ligand7EW1-S1P5-Siponimod-Gi1/β1/γ2
7.14Single4GRVNeurotensin-(8-13)4GRV-NTS1-Neurotensin-(8-13)
7.14Single4XEENeurotensin4XEE-NTS1-Neurotensin
7.14Single4XESNeurotensin4XES-NTS1-Neurotensin
7.14Single6KPGAM8416KPG-CB1-AM841-Gi1/β1/γ2
7.14Single6OS0Angiotensinogen6OS0-AT1-Angiotensinogen
7.14Single6OS2TRV0266OS2-AT1-TRV026
7.14Single6OSAJMV4496OSA-NTS1-JMV449-Gi1/β1/γ2
7.14Single6XOXOrforglipron6XOX-GLP-1-Orforglipron-chim(NtGi1-Gs)/β1/γ2
7.14Single6YVRNTS8-136YVR-NTS1-NTS8-13
7.14Single7EVYSiponimod7EVY-S1P1-Siponimod-Gi1/β1/γ2
7.14Single7EW2Fingolimod7EW2-S1P3-Fingolimod-Gi1/β1/γ2
7.14Single7L0SNeurotensin7L0S-NTS1-Neurotensin-Gi1/β1/γ1
7.14Single7W0NElabela7W0N-Apelin-Elabela-Gi1/β1/γ2
7.14Single7XW5ML1097XW5-TSH-TSH-ML109-Gs/β1/γ2
7.14Single8IBUErythromycin-A8IBU-Motilin-Erythromycin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
7.14Single8JPBNeurotensin-(8-13)8JPB-NTS1-Neurotensin-(8-13)-PubChem 118610427; GDP; Mg-Gq; GRK2
7.14Single8JPCNeurotensin-(8-13)8JPC-NTS1-Neurotensin-(8-13)-PubChem 118610427; GDP; Mg-Gq; GRK2
7.14Single8T3QDocosa-4,7,10,13,16,19-Hexaenoic acid8T3Q-FFA4-Docosa-4,7,10,13,16,19-Hexaenoic acid-chim(NtGi2L-Gs-CtGq)/β1/γ2
7.14Single8U26Protachykinin-18U26-NK1-Protachykinin-1-Gs/β1/γ2
7.14Single8XQJJN2418XQJ-Apelin-JN241
7.14Single8XWACXCL18XWA-CXCR2-CXCL1
7.14Single8XWMCXCL68XWM-CXCR2-CXCL6
7.14Single8XWSCXCL58XWS-CXCR2-CXCL5
7.14Single8XX3CXCL38XX3-CXCR2-CXCL3-Go/β1/γ2
7.14Single9IZHLPA9IZH-LPA1-LPA-chim(NtGi2-G13)/β1/γ2
7.14Consensuscannabinoid_offOrthosteric Ligandcb2_off cb1_off
7.14Consensusccr8_onOrthosteric Ligand8KFX-CCR8-LMD-009-Gi1/β1/γ2 8KFY-CCR8-ZK-756326-Gi1/β1/γ2 8U1U-CCR8-CCL1-Gi1/β1/γ2
7.14Consensuscxcr_onOrthosteric Ligandcxcr3_on cxcr4_on cxcr1_on cxcr2_on
7.14Consensusgi_lipidOrthosteric Ligandgi_cannabinoid gi_ffa gi_leukotriene gi_lpa gi_s1p
7.14Consensusgi_neurotensinOrthosteric Ligand6OSA-NTS1-JMV449-Gi1/β1/γ2 7L0S-NTS1-Neurotensin-Gi1/β1/γ1
7.14Consensuslipid_offonOrthosteric Ligandlipid_off lipid_on
7.14Consensuslipid_offon_gpOrthosteric Ligandlipid_on_gp lipid_off
7.14Consensuslpa1_offOrthosteric Ligand4Z36-LPA1-ONO-3080573 4Z35-LPA1-ONO-9910539 4Z34-LPA1-ONO-9780307
7.14Consensuslpa_offOrthosteric Ligandlpa1_off
7.14Consensuslpl_offOrthosteric Ligands1p_off lpa_off
7.14Consensusmop_onOrthosteric Ligand8F7R-μ-Endomorphin-Gi1/β1/γ2 8EF5-μ-Fentanyl-Gi1/β1/γ2 7SCG-μ-FH210-Gi1/β1/γ2 7T2H-μ-Lofentanil-Gi1/β1/γ2 7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2 8EF6-μ-Morphine-Gi1/β1/γ2 8EFB-μ-Oliceridine-Gi1/β1/γ2 7U2L-μ-PubChem 163201242-Gi1/β1/γ2 8EFO-μ-PZM21-Gi1/β1/γ2 8EFL-μ-SR17018-Gi1/β1/γ2 8F7Q-μ-β-Endorphin-Gi1/β1/γ2 7U2K-μ-C6-guano-Gi1/β1/γ2 8EFQ-μ-Damgo-Gi1/β1/γ2
7.14Consensusmop_on_gpOrthosteric Ligand8F7R-μ-Endomorphin-Gi1/β1/γ2 8EF5-μ-Fentanyl-Gi1/β1/γ2 7SCG-μ-FH210-Gi1/β1/γ2 7T2H-μ-Lofentanil-Gi1/β1/γ2 7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2 8EF6-μ-Morphine-Gi1/β1/γ2 8EFB-μ-Oliceridine-Gi1/β1/γ2 7U2L-μ-PubChem 163201242-Gi1/β1/γ2 8EFO-μ-PZM21-Gi1/β1/γ2 8EFL-μ-SR17018-Gi1/β1/γ2 8F7Q-μ-β-Endorphin-Gi1/β1/γ2 7U2K-μ-C6-guano-Gi1/β1/γ2 8EFQ-μ-Damgo-Gi1/β1/γ2
7.14Consensusmotilin_on_gpOrthosteric Ligand8IBU-Motilin-Erythromycin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
7.14Consensusneurotensin_on_gpOrthosteric Ligandnts1_on_gp
7.14Consensusnts1_on_gpOrthosteric Ligand6OSA-NTS1-JMV449-Gi1/β1/γ2 7L0S-NTS1-Neurotensin-Gi1/β1/γ1
7.14Consensuss1p1_onOrthosteric Ligand7VIE-S1P1-S1P-Gi1/β1/γ2 7VIF-S1P1-S-FTY720-P-Gi1/β1/γ2 7VIG-S1P1-CBP-307-Gi1/β1/γ2 7EVY-S1P1-Siponimod-Gi1/β1/γ2 7EVZ-S1P1-Cenerimod-Gi1/β1/γ2 7EW0-S1P1-Ozanimod-Gi1/β1/γ2 7EW7-S1P1-SEW2871-Gi1/β1/γ2
7.14Consensuss1p1_on_gpOrthosteric Ligand7VIE-S1P1-S1P-Gi1/β1/γ2 7VIF-S1P1-S-FTY720-P-Gi1/β1/γ2 7VIG-S1P1-CBP-307-Gi1/β1/γ2 7EVY-S1P1-Siponimod-Gi1/β1/γ2 7EVZ-S1P1-Cenerimod-Gi1/β1/γ2 7EW0-S1P1-Ozanimod-Gi1/β1/γ2 7EW7-S1P1-SEW2871-Gi1/β1/γ2
7.14Consensuss1p3_onOrthosteric Ligand7EW3-S1P3-S1P-Gi1/β1/γ2 7EW4-S1P3-CYM5541-Gi1/β1/γ2 7EW2-S1P3-Fingolimod-Gi1/β1/γ2
6.67Single4BUONeurotensin4BUO-NTS1-Neurotensin
6.67Single4RWSvMIP-II4RWS-CXCR4-vMIP-II
6.67Single4Z35ONO-99105394Z35-LPA1-ONO-9910539
6.67Single6M1HMaxadilan6M1H-PAC1-Maxadilan-Gs/β1/γ2
6.67Single6UP7Neurotensin6UP7-NTS1-Neurotensin-Arrestin2
6.67Single7EVZCenerimod7EVZ-S1P1-Cenerimod-Gi1/β1/γ2
6.67Single7EW0Ozanimod7EW0-S1P1-Ozanimod-Gi1/β1/γ2
6.67Single7LLLExendin-47LLL-GLP-1-Exendin-4-Gs/β1/γ2
6.67Single7P00Substance-P7P00-NK1-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
6.67Single7VVNPTH7VVN-PTH1-PTH-Gs/β1/γ2
6.67Single7X8RBOC57X8R-GLP-1-BOC5-Gs/β1/γ2
6.67Single7YU8ONO-07405567YU8-LPA1-ONO-0740556-Gi1/β1/γ2
6.67Single8FN0Neurotensin/Neuromedin-N8FN0-NTS1-Neurotensin/Neuromedin-N-PubChem 118610427-chim(NtGi1-Go)/β1/γ2
6.67Single8IYSTUG-8918IYS-FFA4-TUG-891-GDP-chim(NtGi1L-Gq)/β1/γ2
6.67Single8JPFNeurotensin8JPF-NTS1-Neurotensin-PubChem 118610427
6.67Single8K4OCXCL18K4O-KSHV-CXCL1-Gi1/β1/γ1
6.67Single8XVUCXCL28XVU-CXCR2-CXCL2
6.67Single8XWFCXCL38XWF-CXCR2-CXCL3
6.67Single8XWVCXCL18XWV-CXCR2-CXCL1-Go/β1/γ2
6.67Single8XXHCXCL28XXH-CXCR2-CXCL2-Go/β1/γ2
6.67Single8ZX4Lysophosphatidylinositol 8ZX4-GPR55-Lysophosphatidylinositol-chim(NtGi1-G13)/β1/γ2
6.67Single9GE3Lysophosphatidylinositol9GE3-GPR55-Lysophosphatidylinositol-chim(CtGi1-G13)/β1/γ2
6.67Single9IZFNKP9IZF-LPA1-NKP-Gi1/β1/γ2
6.67Consensusclass-a_onOrthosteric Ligandsensory_on alicarboxylic_on amine_on lipid_on nucleotide_on peptide_on protein_on
6.67Consensusgi_s1pOrthosteric Ligand7VIE-S1P1-S1P-Gi1/β1/γ2 7EW3-S1P3-S1P-Gi1/β1/γ2 7EVY-S1P1-Siponimod-Gi1/β1/γ2 7EW1-S1P5-Siponimod-Gi1/β1/γ2 7VIF-S1P1-S-FTY720-P-Gi1/β1/γ2 7VIG-S1P1-CBP-307-Gi1/β1/γ2 7EVZ-S1P1-Cenerimod-Gi1/β1/γ2 7EW4-S1P3-CYM5541-Gi1/β1/γ2 7EW2-S1P3-Fingolimod-Gi1/β1/γ2 7EW0-S1P1-Ozanimod-Gi1/β1/γ2 7EW7-S1P1-SEW2871-Gi1/β1/γ2
6.67Consensusnk1_onOrthosteric Ligand7P00-NK1-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
6.67Consensusnk1_on_gpOrthosteric Ligand7P00-NK1-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
6.25Single5VBLApelin mimetic peptide agonist5VBL-Apelin-Apelin mimetic peptide agonist
6.25Single6KNMJN241-96KNM-Apelin-JN241-9
6.25Single6OS9JMV4496OS9-NTS1-JMV449-Gi1/β1/γ2
6.25Single7AUESetmelanotide7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2
6.25Single7RKFFractalkine7RKF-US28-Fractalkine-GDP-chim(NtGi1-G11)/β1/γ2
6.25Single7RKNFractalkine7RKN-US28-Fractalkine-Gi1/β1/γ2
6.25Single7RMGSubstance-P7RMG-NK1-Substance-P-chim(Gs-CtGq)/β1/γ2
6.25Single7RMHSubstance-P7RMH-NK1-Substance-P-Gs/β1/γ2
6.25Single7X8SWB4-247X8S-GLP-1-WB4-24-Gs/β1/γ2
6.25Single7XBXCX3CL17XBX-CX3CR1-CX3CL1-Gi1/β1/γ2
6.25Single8H4IDoconexent8H4I-FFA4-Doconexent-chim(NtGi1-Gs)/β1/γ2
6.25Single8JBFSenktide8JBF-NK3-Senktide-chim(NtGi1-Gs-CtGq)/β1/γ2
6.25Single8QJ2pN1628QJ2-MC4-pN162-Gs
6.25Single8XQJJN2418XQJ-Apelin-JN241
6.25Single8XX6CXCL88XX6-CXCR2-CXCL8-Go/β1/γ2
6.25Single9ERXD9-THC analog9ERX-CB1-D9-THC analog-Gi1/β1/γ2
6.25Consensuscxcr3_onOrthosteric Ligand8HNK-CXCR3-CXCL11-Gi1/β1/γ2 8HNL-CXCR3-PS372424-Gi1/β1/γ2
6.25Consensuscxcr4_offOrthosteric Ligand4RWS-CXCR4-vMIP-II 3OE0-CXCR4-CVX15 3OE6-CXCR4-IT1t
6.25Consensuscxcr_on_gpOrthosteric Ligandcxcr3_on_gp cxcr4_on_gp cxcr1_on_gp cxcr2_on_gp
6.25Consensuss1p_onOrthosteric Ligands1p1_on s1p3_on s1p5_on
6.25Consensuss1p_on_gpOrthosteric Ligands1p1_on_gp s1p3_on_gp s1p5_on_gp
5.88Single4XT1Fractalkine4XT1-US28-Fractalkine
5.88Single6X19CHU-1286X19-GLP-1-CHU-128-Gs/β1/γ2
5.88Single7F54Afamelanotide7F54-MC4-Afamelanotide-Gs/β1/γ2
5.88Single7L0RNeurotensin7L0R-NTS1-Neurotensin-Gi1/β1/γ1
5.88Single7RTBPeptide-197RTB-GLP-1-Peptide-19-Gs/β1/γ2
5.88Single7TD4Siponimod7TD4-S1P1-Siponimod-Gi1/β1/γ2
5.88Single7VLACCL15(27-92)7VLA-CCR1-CCL15(27-92)-Gi1/β1/γ2
5.88Single7W0PElabela7W0P-Apelin-Elabela-Gi1/β1/γ2
5.88Single7W2ZGhrelin7W2Z-Ghrelin-Ghrelin-Go/β1/γ2
5.88Single8JIQPeptide-158JIQ-Glucagon-Peptide-15-Gs/β1/γ2
5.88Single8K3ZCXCL128K3Z-CXCR4-CXCL12-Gi1/β1/γ1
5.88Single8U4OCXCL128U4O-CXCR4-CXCL12-Cholesterol-Gi1/β1/γ2
5.88Single8WZ2Orexigenic Neuropeptide QRFP8WZ2-QRFP-Orexigenic Neuropeptide QRFP-chim(NtGi1L-Gs-CtGq)/β1/γ2
5.88Single8XFTR-spondin-28XFT-LGR4-R-spondin-2-ZNRF3
5.88Single8XGMChemerin8XGM-CML2-Chemerin-Gi1/β1/γ2
5.88Single8XWNCXCL88XWN-CXCR2-CXCL8
5.88Single8Y69R-spondin-28Y69-LGR4-R-spondin-2-Cholesterol-ZNRF3
5.88Single9L3YRetinoic acid receptor responder protein 29L3Y-CML2-Retinoic acid receptor responder protein 2-Gi1/β1/γ2
5.88Consensusccr1_onOrthosteric Ligand7VLA-CCR1-CCL15(27-92)-Gi1/β1/γ2
5.88Consensusccr1_on_gpOrthosteric Ligand7VLA-CCR1-CCL15(27-92)-Gi1/β1/γ2
5.88Consensuschemokine_onOrthosteric Ligandccr_on cxcr_on
5.88Consensusclass-a_on_gpOrthosteric Ligandsensory_on_gp alicarboxylic_on_gp amine_on_gp lipid_on_gp nucleotide_on_gp peptide_on_gp protein_on_gp
5.88Consensuscxcr4_onOrthosteric Ligand8K3Z-CXCR4-CXCL12-Gi1/β1/γ1
5.88Consensusgi_opioidOrthosteric Ligand8F7R-μ-Endomorphin-Gi1/β1/γ2 8EF5-μ-Fentanyl-Gi1/β1/γ2 7SCG-μ-FH210-Gi1/β1/γ2 7T2H-μ-Lofentanil-Gi1/β1/γ2 7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2 8DZP-κ-momSalB-Gi1/β1/γ2 8EF6-μ-Morphine-Gi1/β1/γ2 8F7X-NOP-Nociceptin-Gi1/β1/γ2 8EFB-μ-Oliceridine-Gi1/β1/γ2 7U2L-μ-PubChem 163201242-Gi1/β1/γ2 8EFO-μ-PZM21-Gi1/β1/γ2 8EFL-μ-SR17018-Gi1/β1/γ2 8F7Q-μ-β-Endorphin-Gi1/β1/γ2 7U2K-μ-C6-guano-Gi1/β1/γ2 8EFQ-μ-Damgo-Gi1/β1/γ2 8F7S-δ-Deltorphin-Gi1/β1/γ2 8F7W-κ-Dynorphin-Gi1/β1/γ2
5.88Consensuslpl_onOrthosteric Ligands1p_on lpa_on
5.88Consensuslpl_on_gpOrthosteric Ligands1p_on_gp lpa_on_gp
5.88Consensusmc4_onOrthosteric Ligand7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2 7F58-MC4-THIQ-Gs/β1/γ2 7F54-MC4-Afamelanotide-Gs/β1/γ2 7F53-MC4-α-MSH-Gs/β1/γ2 7F55-MC4-Bremelanotide-Gs/β1/γ2
5.88Consensusnk3_onOrthosteric Ligand8JBF-NK3-Senktide-chim(NtGi1-Gs-CtGq)/β1/γ2
5.88Consensusnk3_on_gpOrthosteric Ligand8JBF-NK3-Senktide-chim(NtGi1-Gs-CtGq)/β1/γ2
5.88Consensusp2y_onOrthosteric Ligandp2y1_on p2y10_on p2y12_on
5.56Single6DO1Angiotensin-like peptide S1I86DO1-AT1-Angiotensin-like peptide S1I8
5.56Single6WHCGlu16 analog of GCG6WHC-Glucagon-Glu16 analog of GCG-Gs/β1/γ2
5.56Single7C6A(Sar1,Ile8)-Angiotensin II7C6A-AT2-(Sar1,Ile8)-Angiotensin II
5.56Single7E14Orforglipron7E14-GLP-1-Orforglipron-PubChem 156022738-Gs/β1/γ2
5.56Single7F1QMIP-1a7F1Q-CCR5-MIP-1a-Gi1/β1/γ2
5.56Single7PIVSetmelanotide7PIV-MC4-Setmelanotide-Gs/β1/γ2
5.56Single7RKMFractalkine7RKM-US28-Fractalkine-Gi1/β1/γ2
5.56Single7RMISubstance-P7RMI-NK1-Substance-P-chim(Gs-CtGq)/β1/γ2
5.56Single7SK5CXCL127SK5-ACKR3-CXCL12
5.56Single7TRYUrocortin7TRY-CRF2-Urocortin-chim(NtGi1-G11)/β1/γ2
5.56Single7VBINon-Acylated Tirzepatide7VBI-GLP-1-Non-Acylated Tirzepatide-Gs/β1/γ2
5.56Single8F7QBeta-Endorphin8F7Q-μ-β-Endorphin-Gi1/β1/γ2
5.56Single8IBVMotilin8IBV-Motilin-Motilin-chim(NtGi1-Gs-CtGq)/β1/γ2
5.56Single8IOCGamma-MSH8IOC-MC3-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
5.56Single8JZZC5a-desArg8JZZ-C5a1-C5a-desArg-Go/β1/γ2
5.56Single8Z7JAgonistic antibody8Z7J-Apelin-Agonistic antibody-Gi1/β1/γ2
5.56Consensusccr8_on_gpOrthosteric Ligand8KFX-CCR8-LMD-009-Gi1/β1/γ2 8KFY-CCR8-ZK-756326-Gi1/β1/γ2 8U1U-CCR8-CCL1-Gi1/β1/γ2
5.56Consensuscompl-peptide_onOrthosteric Ligandc5a1_on c3a_on
5.56Consensusmc4_on_gpOrthosteric Ligand7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2 7F58-MC4-THIQ-Gs/β1/γ2 7F54-MC4-Afamelanotide-Gs/β1/γ2 7F53-MC4-α-MSH-Gs/β1/γ2 7F55-MC4-Bremelanotide-Gs/β1/γ2
5.56Consensuss1p3_on_gpOrthosteric Ligand7EW3-S1P3-S1P-Gi1/β1/γ2 7EW4-S1P3-CYM5541-Gi1/β1/γ2 7EW2-S1P3-Fingolimod-Gi1/β1/γ2
5.56Consensustachykinin_on_gpOrthosteric Ligandnk1_on_gp nk2_on_gp nk3_on_gp
5.26Single3OE0CVX153OE0-CXCR4-CVX15
5.26Single6LW5WKYMVm6LW5-FPR2-ALX-WKYMVm
5.26Single6MEOEnvelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd46MEO-CCR5-Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4
5.26Single6UUNAdrenomedullin6UUN-CT Like (AM1)-Adrenomedullin-Gs/β1/γ2; RAMP2
5.26Single7O7F6P4-CCL57O7F-CCR5-6P4-CCL5-Gi1/β1/γ1
5.26Single7RYCOxytocin7RYC-OT-Oxytocin-chim(NtGi2L-Gs-CtGq)/β1/γ2
5.26Single7TD0LPA7TD0-LPA1-LPA-Gi1/β1/γ2
5.26Single7TD2LPA7TD2-LPA1-LPA-Gi1/β1/γ2
5.26Single7XA3CCL27XA3-CCR2-CCL2-Gi1/β1/γ2
5.26Single8K6NPro-neuropeptide-Y8K6N-Y2-Pro-neuropeptide-Y-Gi2/β1/γ1
5.26Single8WKZSBL-MC-318WKZ-MC4-SBL-MC-31
5.26Single8WVUR-spondin-18WVU-LGR4-R-spondin-1-RNF43
5.26Single8XZHMM078XZH-Apelin-MM07-Gi1/β1/γ2
5.26Single8Y69R-spondin-28Y69-LGR4-R-spondin-2-Cholesterol-ZNRF3
5.26Single9IVMGLP-1 (Truncated)9IVM-GLP-1-GLP-1 (Truncated)-LSN3318839-chim(NtGi1-Gs)/β2/γ2
5.26Single9K27PrRP319K27-PrRP-PrRP31-chim(NtGi1-Gq)/β1/γ2
5.26Consensusangiotensin_onOrthosteric Ligandat1_on
5.26Consensusat1_onOrthosteric Ligand7F6G-AT1-SAR1-AngII-Gq/β1/γ2
5.26Consensusc5a1_onOrthosteric Ligand8HK5-C5a1-Complement C5-Gi1/β1/γ2 7Y66-C5a1-BM213-Gi1/β1/γ2 7Y67-C5a1-C089 peptide-Gi1/β1/γ2 7Y64-C5a1-C5a anaphylatoxin-Gi1/β1/γ2
5.26Consensusccr2_onOrthosteric Ligand7XA3-CCR2-CCL2-Gi1/β1/γ2
5.26Consensusccr2_on_gpOrthosteric Ligand7XA3-CCR2-CCL2-Gi1/β1/γ2
5.26Consensusccr_onOrthosteric Ligandccr6_on ccr8_on ccr2_on ccr1_on ccr5_on
5.26Consensuscompl-peptide_on_gpOrthosteric Ligandc5a1_on_gp c3a_on_gp
5.26Consensuscxcr4_on_gpOrthosteric Ligand8K3Z-CXCR4-CXCL12-Gi1/β1/γ1
5.26Consensusmc3_onOrthosteric Ligand8IOC-MC3-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
5.26Consensusmc3_on_gpOrthosteric Ligand8IOC-MC3-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
5.00Single5WB2CX3CL1.355WB2-US28-CX3CL1.35
5.00Single6M1IPACAP6M1I-PAC1-PACAP-Gs/β1/γ2
5.00Single6METEnvelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd46MET-CCR5-Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4
5.00Single6WI9Secretin6WI9-Secretin-Secretin-Gs/β1/γ2
5.00Single7DW9AVP7DW9-V2-AVP-chim(NtGi1-Gs)/β1/γ2
5.00Single7F6GSAR1-AngII7F6G-AT1-SAR1-AngII-Gq/β1/γ2
5.00Single7FIMTirzepatide7FIM-GLP-1-Tirzepatide-Gs/β1/γ2
5.00Single7FINPeptide-20; GGL7FIN-GIP-Peptide-20; GGL-Gs/β1/γ2
5.00Single7TYIAmylin7TYI-CT-Amylin-Gs/β1/γ2
5.00Single7YONPeptide-YY(3-36)7YON-Y2-Peptide-YY(3-36)-Gi1/β1/γ2
5.00Single8H4KGW95088H4K-FFA4-GW9508-chim(NtGi1-Gs-CtGq)/β1/γ2
5.00Single8HA0PTH8HA0-PTH1-PTH-chim(NtGi1-Gs)/β1/γ2
5.00Single8XFPR-spondin-28XFP-LGR4-R-spondin-2-ZNRF3
5.00Single8XZJWN3538XZJ-Apelin-WN353-Gi1/β1/γ2
5.00Single8YW3Retatrutide8YW3-GLP-1-Retatrutide-Gs/β1/γ2
5.00Single8YW4Retatrutide8YW4-GIP-Retatrutide-chim(NtGi1-Gs)/β1/γ22
5.00Single8YW5Retatrutide8YW5-Glucagon-Retatrutide-Gs/β1/γ2
5.00Consensusangiotensin_on_gpOrthosteric Ligandat1_on_gp
5.00Consensusat1_on_gpOrthosteric Ligand7F6G-AT1-SAR1-AngII-Gq/β1/γ2
5.00Consensusc5a1_on_gpOrthosteric Ligand8HK5-C5a1-Complement C5-Gi1/β1/γ2 7Y66-C5a1-BM213-Gi1/β1/γ2 7Y67-C5a1-C089 peptide-Gi1/β1/γ2 7Y64-C5a1-C5a anaphylatoxin-Gi1/β1/γ2
5.00Consensuscxcr3_on_gpOrthosteric Ligand8HNK-CXCR3-CXCL11-Gi1/β1/γ2 8HNL-CXCR3-PS372424-Gi1/β1/γ2
5.00Consensusgi_class-aOrthosteric Ligandgi_peptide gi_sensory gi_alicarboxylic gi_amine gi_lipid gi_nucleotide gi_protein
5.00Consensusgq_angiotensinOrthosteric Ligand7F6G-AT1-SAR1-AngII-Gq/β1/γ2
5.00Consensusgs_vasop-oxyOrthosteric Ligand7DW9-V2-AVP-chim(NtGi1-Gs)/β1/γ2
5.00Consensusp2y_on_gpOrthosteric Ligandp2y1_on_gp p2y10_on_gp p2y12_on_gp
5.00Consensusprotein_offonOrthosteric Ligandprotein_off protein_on
5.00Consensusprotein_offon_gpOrthosteric Ligandprotein_on_gp protein_off
5.00Consensusprotein_onOrthosteric Ligandchemokine_on chemerin_on
5.00Consensustachykinin_onOrthosteric Ligandnk1_on nk2_on nk3_on
5.00Consensusv2_onOrthosteric Ligand7DW9-V2-AVP-chim(NtGi1-Gs)/β1/γ2
5.00Consensusv2_on_gpOrthosteric Ligand7DW9-V2-AVP-chim(NtGi1-Gs)/β1/γ2
5.00Consensusvasop-oxy_onOrthosteric Ligandv2_on
5.00Consensusvasop-oxy_on_gpOrthosteric Ligandv2_on_gp
4.76Single5YQZGlucagon analogue5YQZ-Glucagon-Glucagon analogue
4.76Single6X18GLP-16X18-GLP-1-GLP-1-Gs/β1/γ2
4.76Single7F6HBradykinin7F6H-BK2-Bradykinin-Gq/β1/γ2
4.76Single7F6IKallidin7F6I-BK2-Kallidin-Gq/β1/γ2
4.76Single7F9YGhrelin-287F9Y-Ghrelin-Ghrelin-28-chim(NtGi1-Gs-CtGq)/β1/γ2
4.76Single7LLYOxyntomodulin7LLY-GLP-1-Oxyntomodulin-Gs/β1/γ2
4.76Single7P02Protachykinin-17P02-NK1-Protachykinin-1-chim(NtGi1-Gs)/β1/γ2
4.76Single7TYHCalcitonin-17TYH-CT (AMY2)-Calcitonin-1-Gs/β1/γ2; RAMP2
4.76Single7TYWCalcitonin-17TYW-CT (AMY1)-Calcitonin-1-Gs/β1/γ2; RAMP1
4.76Single7VL9CCL15(26-92)7VL9-CCR1-CCL15(26-92)-Gi1/β1/γ2
4.76Single7WBJPACAP277WBJ-VPAC1-PACAP27-Gs/β1/γ2
4.76Single7X9BNeuropeptide-Y7X9B-Y2-Neuropeptide-Y-Gi1/β1/γ2
4.76Single7Y35Abaloparatide7Y35-PTH1-Abaloparatide-Gs/β1/γ2
4.76Single7Y64C5a anaphylatoxin7Y64-C5a1-C5a anaphylatoxin-Gi1/β1/γ2
4.76Single8E3YPACAP278E3Y-VPAC1-PACAP27-Gs/β1/γ2
4.76Single8E3ZVIP8E3Z-VPAC1-VIP-Gs/β1/γ2
4.76Single8HCQEndothelin-18HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/β1/γ2
4.76Single8HK5Complement C58HK5-C5a1-Complement C5-Gi1/β1/γ2
4.76Single8HNKCXCL118HNK-CXCR3-CXCL11-Gi1/β1/γ2
4.76Single8IA2C5a anaphylatoxin8IA2-C5a1-C5a anaphylatoxin-Go/β1/γ2
4.76Single8XQEApelin-138XQE-Apelin-Apelin-13-Gi1/β1/γ2
4.76Single8XVHEndothelin-18XVH-ETB-Endothelin-1-chim(Gs-CtGq)/β1/γ2
4.76Single8XVIEndothelin-18XVI-ETA-Endothelin-1-chim(Gs-CtGq)/β1/γ2
4.76Single8ZPSPrRP208ZPS-PrRP-PrRP20-chim(NtGi1-Gs-CtGq)/β1/γ2
4.76Consensusccr_on_gpOrthosteric Ligandccr6_on_gp ccr8_on_gp ccr2_on_gp ccr1_on_gp ccr5_on_gp
4.76Consensuschemokine_offOrthosteric Ligandccr_off cxcr_off
4.76Consensuschemokine_on_gpOrthosteric Ligandccr_on_gp cxcr_on_gp
4.76Consensuscxcr_offOrthosteric Ligandcxcr3_off cxcr4_off
4.76Consensuseta_onOrthosteric Ligand8HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/β1/γ2
4.76Consensuseta_on_gpOrthosteric Ligand8HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/β1/γ2
4.76Consensusgi_apelinOrthosteric Ligand8XZH-Apelin-MM07-Gi1/β1/γ2 7W0M-Apelin-PubChem 122701908-Gi1/β1/γ2 8XZJ-Apelin-WN353-Gi1/β1/γ2 8XZF-Apelin-WN561-Gi1/β1/γ2 8XZG-Apelin-Apelin-13-Gi1/β1/γ2
4.76Consensusgi_chemokineOrthosteric Ligand6WWZ-CCR6-CCL20-Go/β1/γ2 8HNK-CXCR3-CXCL11-Gi1/β1/γ2 8K3Z-CXCR4-CXCL12-Gi1/β1/γ1 8IC0-CXCR1-Interleukin-8-Gi1/β1/γ2 6LFM-CXCR2-Interleukin-8-Gi1/β1/γ2 8KFX-CCR8-LMD-009-Gi1/β1/γ2 7F1Q-CCR5-MIP-1a-Gi1/β1/γ2 8HNL-CXCR3-PS372424-Gi1/β1/γ2 8KFY-CCR8-ZK-756326-Gi1/β1/γ2 7O7F-CCR5-6P4-CCL5-Gi1/β1/γ1 8U1U-CCR8-CCL1-Gi1/β1/γ2 7VLA-CCR1-CCL15(27-92)-Gi1/β1/γ2 7XA3-CCR2-CCL2-Gi1/β1/γ2
4.76Consensusopioid_onOrthosteric Ligandmop_on nop_on dop_on kop_on
4.55Single4XT3Fractalkine4XT3-US28-Fractalkine
4.55Single5UIW5P7-CCL55UIW-CCR5-5P7-CCL5
4.55Single6FJ3PTH6FJ3-PTH1-PTH
4.55Single6NBFLong-Acting PTH Analog6NBF-PTH1-Long-Acting PTH Analog-Gs/β1/γ2
4.55Single6NBILong-Acting PTH Analog6NBI-PTH1-Long-Acting PTH Analog-Gs/β1/γ2
4.55Single7KI0Semaglutide7KI0-GLP-1-Semaglutide-Gs/β1/γ2
4.55Single7RA3GIP7RA3-GIP-GIP-chim(NtGi1-Gs)/β1/γ2
4.55Single7RGPTirzepatide7RGP-GLP-1-Tirzepatide-chim(NtGi1-Gs)/β1/γ2
4.55Single7SK3CXCL127SK3-ACKR3-CXCL12
4.55Single7SK4CXCL12_LRHQ7SK4-ACKR3-CXCL12_LRHQ
4.55Single7VABNon-Acylated Tirzepatide7VAB-GIP-Non-Acylated Tirzepatide-chim(NtGi1-Gs)/β1/γ2
4.55Single8E3XPACAP278E3X-PAC1-PACAP27-Gs/β1/γ2
4.55Single8FLRPTHrP(1-36)8FLR-PTH1-PTHrP(1-36)-Gs/β1/γ2
4.55Single8JISPeptide-158JIS-GLP-1-Peptide-15-chim(NtGi1-Gs)/β1/γ2
4.55Single8XQFApelin-138XQF-Apelin-Apelin-13-Gi1/β1/γ2
4.55Single9J1Pg1:Ox9J1P-GLP-1-g1:Ox-chim(NtGi1-Gs)/β1/γ2
4.55Consensusccr5_offOrthosteric Ligand5UIW-CCR5-5P7-CCL5
4.55Consensusccr5_onOrthosteric Ligand7O7F-CCR5-6P4-CCL5-Gi1/β1/γ1 7F1Q-CCR5-MIP-1a-Gi1/β1/γ2
4.55Consensusccr_offOrthosteric Ligandccr2_off ccr5_off
4.55Consensusgi_compl-peptOrthosteric Ligand8HK5-C5a1-Complement C5-Gi1/β1/γ2 8IA8-C3aB-E7 peptide-Gi1/β1/γ2 7Y66-C5a1-BM213-Gi1/β1/γ2 7Y67-C5a1-C089 peptide-Gi1/β1/γ2 8HK2-C3aB-C3a anaphylatoxin-Gi1/β1/γ2 7Y64-C5a1-C5a anaphylatoxin-Gi1/β1/γ2
4.55Consensusgi_peptideOrthosteric Ligandgi_cck gi_apelin gi_compl-pept gi_endothelin gi_formylpeptide gi_galanin gi_ghrelin gi_npy gi_neurotensin gi_opioid gi_orexin gi_relaxin gi_somatostatin
4.55Consensusgi_proteinOrthosteric Ligandgi_chemokine gi_chemerin
4.55Consensusopioid_on_gpOrthosteric Ligandmop_on_gp nop_on_gp dop_on_gp kop_on_gp
4.55Consensusprotein_on_gpOrthosteric Ligandchemokine_on_gp chemerin_on_gp
4.35Single5NX2GLP-1 (Truncated)5NX2-GLP-1-GLP-1 (Truncated)
4.35Single6B3JExendin-P56B3J-GLP-1-Exendin-P5-Gs/β1/γ2
4.35Single6UVAAdrenomedullin-26UVA-CT Like (AM2)-Adrenomedullin-2-Gs/β1/γ2; RAMP3
4.35Single6VCBGLP-16VCB-GLP-1-GLP-1-LSN3160440-Gs/β1/γ2
4.35Single7DTYGIP7DTY-GIP-GIP-Gs/β1/γ2
4.35Single7F53Alpha-MSH7F53-MC4-α-MSH-Gs/β1/γ2
4.35Single7FIYTirzepatide7FIY-GIP-Tirzepatide-Gs/β1/γ2
4.35Single7S1MEx4-D-Ala7S1M-GLP-1-Ex4-D-Ala-Gs/β1/γ2
4.35Single7TYFAmylin7TYF-CT (AMY1)-Amylin-Gs/β1/γ2; RAMP1
4.35Single7TYNCalcitonin-17TYN-CT-Calcitonin-1-Gs/β1/γ2
4.35Single7VQXPACAP277VQX-VPAC1-PACAP27-Gs/β1/γ2
4.35Single7VVKPTH7VVK-PTH1-PTH-Gs/β1/γ2
4.35Single7YOONeuropeptide-Y7YOO-Y2-Neuropeptide-Y-Gi1/β1/γ2
4.35Single8FU6Glucagon derivative ZP37808FU6-Glucagon-Glucagon derivative ZP3780-Gs/β1/γ2
4.35Single8HAOPTH8HAO-PTH1-PTH-chim(NtGi1-Gs)/β1/γ2
4.35Single8XFSR-spondin-28XFS-LGR4-R-spondin-2-ZNRF3
4.35Single8ZH8QRF-Amide8ZH8-QRFP-QRF-Amide-Gq/β1/γ1
4.35Single8ZJGChemerin8ZJG-CML1-Chemerin-Gi1/β1/γ2
4.35Single9K26PrRP319K26-PrRP-PrRP31-Gi1/β1/γ2
4.35Consensusgq_peptideOrthosteric Ligandgq_cck gq_kisspeptin gq_bradykinin gq_bombesin gq_angiotensin
4.35Consensusnpy2_onOrthosteric Ligand7YOO-Y2-Neuropeptide-Y-Gi1/β1/γ2
4.35Consensusnpy2_on_gpOrthosteric Ligand7YOO-Y2-Neuropeptide-Y-Gi1/β1/γ2
4.35Consensuspeptide_onOrthosteric Ligandcck_on angiotensin_on apelin_on bombesin_on bradykinin_on compl-peptide_on endothelin_on formylpeptide_on galanin_on ghrelin_on kisspeptin_on melanocortin_on motilin_on neuromedin-u_on npy_on neurotensin_on opioid_on orexin_on relaxin_on somatostatin_on tachykinin_on trh_on vasop-oxy_on
4.35Consensuspeptide_on_gpOrthosteric Ligandcck_on_gp angiotensin_on_gp apelin_on_gp bombesin_on_gp bradykinin_on_gp compl-peptide_on_gp endothelin_on_gp formylpeptide_on_gp galanin_on_gp ghrelin_on_gp kisspeptin_on_gp melanocortin_on_gp motilin_on_gp neuromedin-u_on_gp npy_on_gp neurotensin_on_gp opioid_on_gp orexin_on_gp relaxin_on_gp somatostatin_on_gp tachykinin_on_gp trh_on_gp vasop-oxy_on_gp
4.17Single5VAIGLP-15VAI-GLP-1-GLP-1-Gs/β1/γ2
4.17Single6LMKGlucagon6LMK-Glucagon-Glucagon-Gs/β1/γ2
4.17Single6LMLGlucagon6LML-Glucagon-Glucagon-Gi1/β1/γ1
4.17Single6NBHLong-Acting PTH Analog6NBH-PTH1-Long-Acting PTH Analog-Gs/β1/γ2
4.17Single6UUSAdrenomedullin6UUS-CT Like (AM2)-Adrenomedullin-Gs/β1/γ2; RAMP3
4.17Single6WZGSecretin6WZG-Secretin-Secretin-Gs/β1/γ2
4.17Single7D68GLP-27D68-GLP-2-GLP-2-Gs/β1/γ2
4.17Single7KI1Taspoglutide7KI1-GLP-1-Taspoglutide-Gs/β1/γ2
4.17Single7TS0Urocortin7TS0-CRF2-Urocortin-chim(NtGi1L-Go)/β1/γ2
4.17Single7TYLAmylin7TYL-CT-Amylin-Gs/β1/γ2
4.17Single7VVJPTHrP(1-36)7VVJ-PTH1-PTHrP(1-36)-Gs/β1/γ2
4.17Single7VVLPTH7VVL-PTH1-PTH-Gs/β1/γ2
4.17Single8F0KPramlintide Analogue San3858F0K-CT (AMY3)-Pramlintide Analogue San385-Gs/β1/γ2; RAMP3
4.17Single8HAFPTHrP(1-36)8HAF-PTH1-PTHrP(1-36)-chim(NtGi1-Gs)/β1/γ2
4.17Single8IY5Endothelin-18IY5-ETB-Endothelin-1-Gi1/β1/γ2
4.17Single8IY6Endothelin-18IY6-ETB-Endothelin-1
4.17Consensusbk2_onOrthosteric Ligand7F6H-BK2-Bradykinin-Gq/β1/γ2 7F6I-BK2-Kallidin-Gq/β1/γ2
4.17Consensusbk2_on_gpOrthosteric Ligand7F6H-BK2-Bradykinin-Gq/β1/γ2 7F6I-BK2-Kallidin-Gq/β1/γ2
4.17Consensusbradykinin_onOrthosteric Ligandbk2_on
4.17Consensusbradykinin_on_gpOrthosteric Ligandbk2_on_gp
4.17Consensusendothelin_onOrthosteric Ligandetb_on eta_on
4.17Consensusgq_bradykininOrthosteric Ligand7F6H-BK2-Bradykinin-Gq/β1/γ2 7F6I-BK2-Kallidin-Gq/β1/γ2
4.17Consensusgs_melanocortinOrthosteric Ligand7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2 7F54-MC4-Afamelanotide-Gs/β1/γ2 7F4D-MC1-α-MSH-chim(NtGi1-Gs)/β1/γ2 8INR-MC5-α-MSH-Ca-chim(NtGi1-Gs)/β1/γ2 7F53-MC4-α-MSH-Gs/β1/γ2 7F55-MC4-Bremelanotide-Gs/β1/γ2 8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1 8IOC-MC3-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2 8IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/β1/γ2 7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2 7F4I-MC1-SHU9119-chim(NtGi1-Gs)/β1/γ2 7F58-MC4-THIQ-Gs/β1/γ2
4.00Single5GLHEndothelin-15GLH-ETB-Endothelin-1
4.00Single6IGKEndothelin-36IGK-ETB-Endothelin-3
4.00Single7DUQGLP-17DUQ-GLP-1-GLP-1-PubChem 156022738-Gs/β1/γ2
4.00Single7RBTTirzepatide7RBT-GIP-Tirzepatide-PubChem 163183774-chim(NtGi1-Gs)/β1/γ2
4.00Single7TYXAmylin7TYX-CT (AMY2)-Amylin-Gs/β1/γ2; RAMP2
4.00Single8U1UCCL18U1U-CCR8-CCL1-Gi1/β1/γ2
4.00Consensusccr5_on_gpOrthosteric Ligand7O7F-CCR5-6P4-CCL5-Gi1/β1/γ1 7F1Q-CCR5-MIP-1a-Gi1/β1/γ2
4.00Consensusgi_npyOrthosteric Ligand8K6M-Y1-Neuropeptide-Y-Gi2/β1/γ1 7X9C-Y4-Pancreatic Hormone-Gi1/β1/γ2 7YOO-Y2-Neuropeptide-Y-Gi1/β1/γ2
4.00Consensusnpy_onOrthosteric Ligandnpy1_on npy2_on npy4_on
4.00Consensusnpy_on_gpOrthosteric Ligandnpy1_on_gp npy2_on_gp npy4_on_gp
3.85Single6LPBPACAP6LPB-PAC1-PACAP-Gs/β1/γ1
3.85Single7SK6CXCL12_LRHQ7SK6-ACKR3-CXCL12_LRHQ
3.85Single7TZFAmylin7TZF-CT (AMY3)-Amylin-Gs/β1/γ2; RAMP3
3.85Single7VBHPeptide-207VBH-GLP-1-Peptide-20-Gs/β1/γ2
3.85Single8F2APramlintide Analogue San3858F2A-CT (AMY3)-Pramlintide Analogue San385-Gs/β1/γ2; RAMP3
3.85Single8FLSAbaloparatide8FLS-PTH1-Abaloparatide-Gs/β1/γ2
3.85Single8FLULong-Acting PTH8FLU-PTH1-Long-Acting PTH-Gs/β1/γ2
3.85Single9AUCCalcitonin gene-related peptide-19AUC-CT (AMY1)-Calcitonin gene-related peptide-1-Gs/β1/γ2; RAMP1
3.85Consensusendothelin_on_gpOrthosteric Ligandetb_on_gp eta_on_gp
3.85Consensusmelanocortin_onOrthosteric Ligandmc1_on mc4_on mc2_on mc3_on mc5_on
3.85Consensusmelanocortin_on_gpOrthosteric Ligandmc1_on_gp mc4_on_gp mc2_on_gp mc3_on_gp mc5_on_gp
3.70Single6LRYSarafotoxin-B6LRY-ETB-Sarafotoxin-B
3.70Single6WPWGlucagon derivative ZP37806WPW-Glucagon-Glucagon derivative ZP3780-Gs/β1/γ2
3.70Single7V35Peptide-207V35-Glucagon-Peptide-20-Gs/β1/γ2
3.70Single7VVMPTH7VVM-PTH1-PTH-Gs/β1/γ2
3.70Single8JIPMEDI03828JIP-GLP-1-MEDI0382-chim(NtGi1-Gs)/β1/γ2
3.70Single8JIRSAR4258998JIR-GLP-1-SAR425899-chim(NtGi1-Gs)/β1/γ2
3.70Single9JR2PTH9JR2-PTH1-PTH-chim(NtGi1L-Gs-CtGq)/β1/γ2
3.57Single7TYOCalcitonin7TYO-CT-Calcitonin-Gs/β1/γ2
3.57Single7TYYCalcitonin-17TYY-CT (AMY2)-Calcitonin-1-Gs/β1/γ2; RAMP2
3.57Single7X9ANeuropeptide-Y7X9A-Y1-Neuropeptide-Y-Gi1/β1/γ2
3.57Single7Y36Teriparatide7Y36-PTH1-Teriparatide-Gs/β1/γ2
3.57Single8FLQPTH8FLQ-PTH1-PTH-Gs/β1/γ2
3.57Single8JITMEDI03828JIT-Glucagon-MEDI0382-Gs/β1/γ2
3.57Single8JIUSAR4258998JIU-Glucagon-SAR425899-Gs/β1/γ2
3.57Single9JR3PTH9JR3-PTH1-PTH-chim(NtGi1L-Gs-CtGq)/β1/γ2
3.45Single6E3YCalcitonin gene-related peptide-16E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/β1/γ2; RAMP1
3.33Consensusmc2_onOrthosteric Ligand8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1
3.33Consensusmc2_on_gpOrthosteric Ligand8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1
3.23Single7F16TIP397F16-PTH2-TIP39-Gs/β1/γ2
3.12Single8F0JPramlintide Analogue San458F0J-CT-Pramlintide Analogue San45-Gs/β1/γ2
3.03Single8F2BPramlintide Analogue San458F2B-CT (AMY3)-Pramlintide Analogue San45-Gs/β1/γ2; RAMP3
2.78Single8GY7Corticotropin8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1

2D representation of the interactions of this orthosteric/allosteric ligand.


Links and nodes colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:D403 R:R:F405 9.55 0 No Yes 8 8 2 1
R:R:F405 R:R:K565 4.96 5 Yes No 8 7 1 2
R:R:F405 R:R:V566 3.93 5 Yes No 8 9 1 2
R:R:F405 R:R:M572 3.73 5 Yes No 8 9 1 1
R:R:F405 W:W:?1 6.11 5 Yes Yes 8 0 1 0
R:R:P407 R:R:V656 7.07 5 No Yes 9 7 2 1
R:R:M463 R:R:Y667 7.18 0 No Yes 9 9 2 1
R:R:L570 R:R:T501 4.42 5 Yes No 9 9 1 2
R:R:T501 R:R:Y667 4.99 5 No Yes 9 9 2 1
R:R:V502 R:R:Y563 6.31 5 Yes Yes 9 9 2 2
R:R:P571 R:R:V502 3.53 5 Yes Yes 9 9 1 2
R:R:E506 R:R:S505 5.75 0 No No 8 9 2 1
R:R:S505 R:R:Y667 6.36 5 No Yes 9 9 1 1
R:R:S505 W:W:?1 3.23 5 No Yes 9 0 1 0
R:R:P571 R:R:Y563 8.34 5 Yes Yes 9 9 1 2
R:R:M572 R:R:V566 6.09 5 No No 9 9 1 2
R:R:V566 R:R:V656 3.21 5 No Yes 9 7 2 1
R:R:I568 R:R:L570 5.71 0 No Yes 9 9 2 1
R:R:L570 R:R:P571 4.93 5 Yes Yes 9 9 1 1
R:R:L570 R:R:Y667 3.52 5 Yes Yes 9 9 1 1
R:R:L570 W:W:?1 9.93 5 Yes Yes 9 0 1 0
R:R:P571 W:W:?1 4.71 5 Yes Yes 9 0 1 0
R:R:M572 W:W:?1 15.21 5 No Yes 9 0 1 0
R:R:T574 W:W:?1 12.68 0 No Yes 6 0 1 0
R:R:A644 R:R:L587 3.15 0 No No 9 8 1 2
R:R:I640 R:R:P639 3.39 5 No No 9 9 1 2
R:R:I640 R:R:Y667 4.84 5 No Yes 9 9 1 1
R:R:I640 W:W:?1 14.33 5 No Yes 9 0 1 0
R:R:I654 R:R:Y643 12.09 0 No No 9 8 1 2
R:R:L662 R:R:Y643 5.86 0 No No 8 8 1 2
R:R:A644 W:W:?1 6.78 0 No Yes 9 0 1 0
R:R:A647 R:R:P652 3.74 5 No No 9 9 1 1
R:R:A647 W:W:?1 6.78 5 No Yes 9 0 1 0
R:R:P652 W:W:?1 5.89 5 No Yes 9 0 1 0
R:R:I654 R:R:N658 4.25 0 No No 9 8 1 2
R:R:I654 W:W:?1 10.23 0 No Yes 9 0 1 0
R:R:S659 R:R:V656 3.23 5 No Yes 9 7 1 1
R:R:V656 W:W:?1 5.34 5 Yes Yes 7 0 1 0
R:R:S659 W:W:?1 11.84 5 No Yes 9 0 1 0
R:R:F666 R:R:L662 3.65 0 No No 8 8 2 1
R:R:L662 W:W:?1 6.95 0 No Yes 8 0 1 0
R:R:P668 R:R:Y667 4.17 0 No Yes 9 9 2 1
R:R:Y667 W:W:?1 9.25 5 Yes Yes 9 0 1 0
R:R:L580 R:R:T574 2.95 0 No No 4 6 2 1
R:R:E404 W:W:?1 0.95 0 No Yes 7 0 1 0

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

ShowSimilarityNetwork TypeNameLigandDescription
71.43Single7FIHOrg435537FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/β1/γ2
68.75Single7XW6ML1097XW6-TSH-M22 Fab-ML109-Gs/β1/γ2
64.29Single7UTZPubChem 6440787UTZ-TSH-TR1402-PubChem 644078-Gs/β1/γ2
62.50Single8I2GCompound 7163408I2G-FSH-Glycoprotein hormones α chain-Compound 716340-Gs/β1/γ2
58.82Single7XW5ML1097XW5-TSH-TSH-ML109-Gs/β1/γ2
45.00Single5WF6UK-4320975WF6-A2A-UK-432097
44.44Single8FN1Neurotensin/Neuromedin-N8FN1-NTS1-Neurotensin/Neuromedin-N-chim(NtGi1-Go)/β1/γ2
42.11Single8H0QGastrin Releasing Peptide8H0Q-BB2-Gastrin Releasing Peptide-chim(NtGi1-Gs-CtGq)/β1/γ2
42.11Single9L3WRetinoic acid receptor responder protein 29L3W-CML1-Retinoic acid receptor responder protein 2-Gi1/β1/γ2
41.18Single6XBM25(S)-Epoxycholesterol6XBM-SMO-25(S)-Epoxycholesterol-Gi1/β1/γ2
40.91Single3QAKUK-4320973QAK-A2A-UK-432097
40.00Single7EZCUKA7EZC-A2A-UKA
40.00Single8FN0Neurotensin/Neuromedin-N8FN0-NTS1-Neurotensin/Neuromedin-N-PubChem 118610427-chim(NtGi1-Go)/β1/γ2
39.13Single5WF5UK-4320975WF5-A2A-UK-432097
39.13Single9K27PrRP319K27-PrRP-PrRP31-chim(NtGi1-Gq)/β1/γ2
38.89Single7Y26Octreotide7Y26-SST2-Octreotide-chim(NtGi2L-Gs-CtGq)/β1/γ2
38.89Single8ZPTPrRP208ZPT-PrRP-PrRP20-chim(NtGi1-Gs-CtGq)/β1/γ2
38.10Single7YAEOctreotide7YAE-SST2-Octreotide-Gi1/β1/γ2
38.10Single8JBFSenktide8JBF-NK3-Senktide-chim(NtGi1-Gs-CtGq)/β1/γ2
37.50Single5OLOTozadenant5OLO-A2A-Tozadenant-Na
37.50Single6D9HAdenosine6D9H-A1-Adenosine-Gi2/β1/γ2
36.84Single8ID39-Hydroxystearic acid8ID3-FFA4-9-Hydroxystearic acid-Gi1/β1/γ2
36.84Single8UGWPubChem 30865998UGW-A2A-PubChem 3086599
36.36Single7L0RNeurotensin7L0R-NTS1-Neurotensin-Gi1/β1/γ1
36.36Single7W0PElabela7W0P-Apelin-Elabela-Gi1/β1/γ2
36.36Single8ZCJPasireotide8ZCJ-SST5-Pasireotide-Gi1/β1/γ1
36.36Consensusclass-a_on_gpOrthosteric Ligandsensory_on_gp alicarboxylic_on_gp amine_on_gp lipid_on_gp nucleotide_on_gp peptide_on_gp protein_on_gp
36.36Consensusnk3_onOrthosteric Ligand8JBF-NK3-Senktide-chim(NtGi1-Gs-CtGq)/β1/γ2
36.36Consensusnk3_on_gpOrthosteric Ligand8JBF-NK3-Senktide-chim(NtGi1-Gs-CtGq)/β1/γ2
35.29Single2YDOAdenosine2YDO-A2A-Adenosine
35.29Consensusnucleotide_offOrthosteric Ligandadenosine_off p2y_off
35.00Single4XEENeurotensin4XEE-NTS1-Neurotensin
35.00Single4XESNeurotensin4XES-NTS1-Neurotensin
35.00Single6OSAJMV4496OSA-NTS1-JMV449-Gi1/β1/γ2
35.00Single7L0SNeurotensin7L0S-NTS1-Neurotensin-Gi1/β1/γ1
35.00Single7L1UOrexin7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/β1/γ2
35.00Single8JPCNeurotensin-(8-13)8JPC-NTS1-Neurotensin-(8-13)-PubChem 118610427; GDP; Mg-Gq; GRK2
35.00Single8U26Protachykinin-18U26-NK1-Protachykinin-1-Gs/β1/γ2
35.00Consensusgi_neurotensinOrthosteric Ligand6OSA-NTS1-JMV449-Gi1/β1/γ2 7L0S-NTS1-Neurotensin-Gi1/β1/γ1
35.00Consensusneurotensin_on_gpOrthosteric Ligandnts1_on_gp
35.00Consensusnts1_on_gpOrthosteric Ligand6OSA-NTS1-JMV449-Gi1/β1/γ2 7L0S-NTS1-Neurotensin-Gi1/β1/γ1
34.78Single7EZKCholecystokinin-87EZK-CCKA-Cholecystokinin-8-chim(NtGi1-Gs)/β1/γ2
34.78Single8IBVMotilin8IBV-Motilin-Motilin-chim(NtGi1-Gs-CtGq)/β1/γ2
34.62Consensusgi_peptideOrthosteric Ligandgi_cck gi_apelin gi_compl-pept gi_endothelin gi_formylpeptide gi_galanin gi_ghrelin gi_npy gi_neurotensin gi_opioid gi_orexin gi_relaxin gi_somatostatin
33.33Single4BUONeurotensin4BUO-NTS1-Neurotensin
33.33Single4J4QOctyl Beta-D-Glucopyranoside4J4Q-Rhodopsin-Octyl β-D-Glucopyranoside-Gt(CT)
33.33Single6PWCNeurotensin6PWC-NTS1-Neurotensin-Arrestin2
33.33Single6UP7Neurotensin6UP7-NTS1-Neurotensin-Arrestin2
33.33Single6Z4VNTS8-136Z4V-NTS1-NTS8-13
33.33Single7EZHCholecystokinin-87EZH-CCKA-Cholecystokinin-8-Gi1/β1/γ2
33.33Single7EZMCholecystokinin-87EZM-CCKA-Cholecystokinin-8-chim(NtGsL-Gq)/β1/γ2
33.33Single7SK8CXCL127SK8-ACKR3-CXCL12-CCX662
33.33Single7V6A-7V6A-M4-PubChem 9864275-Gi1/β1/γ2
33.33Single7WVVfMLFII7WVV-FPR2-ALX-fMLFII-Gi2/β1/γ2
33.33Single7YOONeuropeptide-Y7YOO-Y2-Neuropeptide-Y-Gi1/β1/γ2
33.33Single8K6NPro-neuropeptide-Y8K6N-Y2-Pro-neuropeptide-Y-Gi2/β1/γ1
33.33Single8X17Namodenoson8X17-A3A-Namodenoson-Gi1/β1/γ2
33.33Single9K26PrRP319K26-PrRP-PrRP31-Gi1/β1/γ2
33.33Consensusa3_onOrthosteric Liganda3a_on
33.33Consensuscck_onOrthosteric Ligandccka_on cckb_on
33.33Consensuscck_on_gpOrthosteric Ligandccka_on_gp cckb_on_gp
33.33Consensusccka_onOrthosteric Ligand7EZH-CCKA-Cholecystokinin-8-Gi1/β1/γ2
33.33Consensusccka_on_gpOrthosteric Ligand7EZH-CCKA-Cholecystokinin-8-Gi1/β1/γ2
33.33Consensuschemerin_onOrthosteric Ligandcml1_on
33.33Consensusgq_peptideOrthosteric Ligandgq_cck gq_kisspeptin gq_bradykinin gq_bombesin gq_angiotensin
33.33Consensusnpy2_onOrthosteric Ligand7YOO-Y2-Neuropeptide-Y-Gi1/β1/γ2
33.33Consensusnpy2_on_gpOrthosteric Ligand7YOO-Y2-Neuropeptide-Y-Gi1/β1/γ2
33.33Consensusnucleotide_offonOrthosteric Ligandnucleotide_off nucleotide_on
33.33Consensusnucleotide_offon_gpOrthosteric Ligandnucleotide_on_gp nucleotide_off
33.33Consensuspeptide_onOrthosteric Ligandcck_on angiotensin_on apelin_on bombesin_on bradykinin_on compl-peptide_on endothelin_on formylpeptide_on galanin_on ghrelin_on kisspeptin_on melanocortin_on motilin_on neuromedin-u_on npy_on neurotensin_on opioid_on orexin_on relaxin_on somatostatin_on tachykinin_on trh_on vasop-oxy_on
33.33Consensuspeptide_on_gpOrthosteric Ligandcck_on_gp angiotensin_on_gp apelin_on_gp bombesin_on_gp bradykinin_on_gp compl-peptide_on_gp endothelin_on_gp formylpeptide_on_gp galanin_on_gp ghrelin_on_gp kisspeptin_on_gp melanocortin_on_gp motilin_on_gp neuromedin-u_on_gp npy_on_gp neurotensin_on_gp opioid_on_gp orexin_on_gp relaxin_on_gp somatostatin_on_gp tachykinin_on_gp trh_on_gp vasop-oxy_on_gp
33.33Consensussomatostatin_onOrthosteric Ligandsst2_on sst4_on sst5_on
33.33Consensussomatostatin_on_gpOrthosteric Ligandsst2_on_gp sst4_on_gp sst5_on_gp
32.00Single7KH0AVP7KH0-V2-AVP-chim(NtGi1-Gs)/β1/γ2
32.00Consensusgi_class-aOrthosteric Ligandgi_peptide gi_sensory gi_alicarboxylic gi_amine gi_lipid gi_nucleotide gi_protein
32.00Consensuspeptide_offon_gpOrthosteric Ligandpeptide_on_gp peptide_off
32.00Consensusprotein_onOrthosteric Ligandchemokine_on chemerin_on
31.82Single4UG2CGS216804UG2-A2A-CGS21680
31.82Single6OS9JMV4496OS9-NTS1-JMV449-Gi1/β1/γ2
31.82Single7F2OBradykinin7F2O-BK2-Bradykinin-chim(NtGi1-Gs-CtGq)/β1/γ2
31.82Single7F8WGastrin-177F8W-CCKB-Gastrin-17-chim(NtGsL-Gq)/β1/γ2
31.82Single7T11Octreotide7T11-SST2-Octreotide-Gi3/β1/γ2
31.82Single7XN9L-054,5227XN9-SST2-L-054,522
31.82Single8IA7Cholecystokinin-88IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/β1/γ2
31.82Single8XQJJN2418XQJ-Apelin-JN241
31.82Consensusformylpeptide_onOrthosteric Ligandfpr2-alx_on fpr1-alx_on
31.82Consensusgq_cckOrthosteric Ligand8IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/β1/γ2 7XOW-CCKB-Gastrin-chim(NtGi1-Gq)/β1/γ2 7EZM-CCKA-Cholecystokinin-8-chim(NtGsL-Gq)/β1/γ2 7F8W-CCKB-Gastrin-17-chim(NtGsL-Gq)/β1/γ2
31.82Consensussst2_onOrthosteric Ligand7WIC-SST2-Somatostatin-14-Gi1/β1/γ2 7WIG-SST2-L-054,264-Gi1/β1/γ2 7YAE-SST2-Octreotide-Gi1/β1/γ2 7YAC-SST2-Paltusotine-Gi1/β1/γ2
31.82Consensussst2_on_gpOrthosteric Ligand7WIC-SST2-Somatostatin-14-Gi1/β1/γ2 7WIG-SST2-L-054,264-Gi1/β1/γ2 7YAE-SST2-Octreotide-Gi1/β1/γ2 7YAC-SST2-Paltusotine-Gi1/β1/γ2
31.58Single5N2RPSB-365N2R-A2A-PSB-36-Na
31.58Single5N2SPSB365N2S-A1-PSB36
31.58Single6GDGNECA6GDG-A2A-NECA-Gs/β1/γ1
31.58Single6XBKCholesterol6XBK-SMO-Cholesterol-Gi1/β1/γ2
31.58Single7CFNINT-7777CFN-GPBA-INT-777-Gs/β1/γ2
31.58Single7LD3Adenosine7LD3-A1-Adenosine-PubChem 25263603-Gi2/β1/γ2
31.58Single8GNEKW-63568GNE-A2A-KW-6356-Na
31.58Single8VVEnorBNI8VVE-κ-norBNI-Gi1/β1/γ2
31.58Consensusa3_on_gpOrthosteric Liganda3a_on_gp
31.58Consensusa3a_onOrthosteric Ligand8X17-A3A-Namodenoson-Gi1/β1/γ2 8X16-A3A-Piclidenoson-Gi1/β1/γ2
31.58Consensusa3a_on_gpOrthosteric Ligand8X17-A3A-Namodenoson-Gi1/β1/γ2 8X16-A3A-Piclidenoson-Gi1/β1/γ2
31.25Single7VDHC48/807VDH-MRGPRX2-C48/80-Gi1/β1/γ2
31.25Single7XT9Serotonin7XT9-5-HT4-Serotonin-Gs/β1/γ2
31.03Consensusgi_npyOrthosteric Ligand8K6M-Y1-Neuropeptide-Y-Gi2/β1/γ1 7X9C-Y4-Pancreatic Hormone-Gi1/β1/γ2 7YOO-Y2-Neuropeptide-Y-Gi1/β1/γ2
31.03Consensusnpy_onOrthosteric Ligandnpy1_on npy2_on npy4_on
31.03Consensusnpy_on_gpOrthosteric Ligandnpy1_on_gp npy2_on_gp npy4_on_gp
30.77Single7F6HBradykinin7F6H-BK2-Bradykinin-Gq/β1/γ2
30.77Single7F6IKallidin7F6I-BK2-Kallidin-Gq/β1/γ2
30.77Single7X9BNeuropeptide-Y7X9B-Y2-Neuropeptide-Y-Gi1/β1/γ2
30.77Single7Y35Abaloparatide7Y35-PTH1-Abaloparatide-Gs/β1/γ2
30.77Single8ZPSPrRP208ZPS-PrRP-PrRP20-chim(NtGi1-Gs-CtGq)/β1/γ2
30.77Consensussst5_on_gpOrthosteric Ligand8X8L-SST5-Cortistatin-chim(NtGi1-Gs-CtGi1)/β1/γ2 8X8N-SST5-Octreotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
30.43Single7F8XNN90567F8X-CCKA-NN9056
30.43Single7WICSomatostatin-147WIC-SST2-Somatostatin-14-Gi1/β1/γ2
30.43Single7WKDTRH7WKD-TRH-TRH-chim(NtGi1-Gs-CtGq)/β1/γ2
30.43Single7XAUOctreotide7XAU-SST2-Octreotide-Gi1/β1/γ2
30.43Single8WDTphotoNECA8WDT-A2A-photoNECA
30.43Single8WZ2Orexigenic Neuropeptide QRFP8WZ2-QRFP-Orexigenic Neuropeptide QRFP-chim(NtGi1L-Gs-CtGq)/β1/γ2
30.43Single9L3YRetinoic acid receptor responder protein 29L3Y-CML2-Retinoic acid receptor responder protein 2-Gi1/β1/γ2
30.43Consensuschemerin_on_gpOrthosteric Ligandcml1_on_gp
30.43Consensuscml1_onOrthosteric Ligand7YKD-CML1-Chemerin-9-Gi1/β1/γ2
30.43Consensusgi_chemerinOrthosteric Ligand7YKD-CML1-Chemerin-9-Gi1/β1/γ2
30.43Consensusnop_onOrthosteric Ligand8F7X-NOP-Nociceptin-Gi1/β1/γ2
30.43Consensusnop_on_gpOrthosteric Ligand8F7X-NOP-Nociceptin-Gi1/β1/γ2
30.00Single2YDVNECA2YDV-A2A-NECA
30.00Single3ZEVNeurotensin3ZEV-NTS1-Neurotensin
30.00Single4BV0Neurotensin4BV0-NTS1-Neurotensin
30.00Single4UHRCGS216804UHR-A2A-CGS21680
30.00Single5G53NECA5G53-A2A-NECA-Gs
30.00Single7L0PNeurotensin7L0P-NTS1-Neurotensin-Gi1/β1/γ1
30.00Single7L0QNeurotensin7L0Q-NTS1-Neurotensin-Gi1/β1/γ1
30.00Single7PX4PSB-21137PX4-A2A-PSB-2113
30.00Single7XOWGastrin7XOW-CCKB-Gastrin-chim(NtGi1-Gq)/β1/γ2
30.00Single7Y24Octreotide7Y24-SST2-Octreotide-Go/β1/γ2
30.00Single8FMZNeurotensin/Neuromedin-N8FMZ-NTS1-Neurotensin/Neuromedin-N-chim(NtGi2L-Gs-CtGq)/β1/γ2
30.00Single8ID6Oleic acid8ID6-FFA4-Oleic acid-Gi1/β1/γ2
30.00Single8YH6Namodenoson8YH6-A3A-Namodenoson-Gi1/β1/γ2
30.00Consensusmotilin_onOrthosteric Ligand8IBU-Motilin-Erythromycin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
30.00Consensusneurotensin_onOrthosteric Ligandnts1_on
30.00Consensusnts1_onOrthosteric Ligand6OSA-NTS1-JMV449-Gi1/β1/γ2 7L0S-NTS1-Neurotensin-Gi1/β1/γ1
29.63Single8H0PNMB308H0P-BB1-NMB30-chim(NtGi1-Gs-CtGq)/β1/γ2
29.63Consensusgi_proteinOrthosteric Ligandgi_chemokine gi_chemerin
29.63Consensusprotein_on_gpOrthosteric Ligandchemokine_on_gp chemerin_on_gp
29.41Single2X72All-trans-Retinal2X72-Rhodopsin-All-trans-Retinal-Gt(CT)
29.41Single3VG9ZM-2413853VG9-A2A-ZM-241385-Antibody
29.41Single5K2DZM-2413855K2D-A2A-ZM-241385-Na
29.41Single6JZHZM-2413856JZH-A2A-ZM-241385-Na
29.41Single6NWEOctyl-Beta-D-Glucopyranoside6NWE-Rhodopsin-Octyl-β-D-Glucopyranoside-Gt(CT)
29.41Single6PS7ZM-2413856PS7-A2A-ZM-241385-Na
29.41Single7LD4Adenosine7LD4-A1-Adenosine-Gi2/β1/γ2
29.41Single7VUJJNJ-635330547VUJ-GPR139-JNJ-63533054-GDP-chim(Gs-CtGq)/β1/γ2
29.41Single7XT8Serotonin7XT8-5-HT4-Serotonin-Gs/β1/γ2
29.41Single8GNGIstradefylline8GNG-A2A-Istradefylline
29.41Single8HDPAdenosine8HDP-A2B-Adenosine-Gs/β1/γ2
29.41Single8RVWStilSwitch38RVW-A2A-StilSwitch3-Na
29.41Single8RW4AzoSwitch28RW4-A2A-AzoSwitch2-Na
29.41Single8RWEStilSwitch48RWE-A2A-StilSwitch4-Na
29.41Single9FUPIstradefylline9FUP-A2A-Istradefylline-Na
29.41Consensusa1_onOrthosteric Ligand7LD4-A1-Adenosine-Gi2/β1/γ2
29.41Consensusa1_on_gpOrthosteric Ligand7LD4-A1-Adenosine-Gi2/β1/γ2
29.17Single6DO1Angiotensin-like peptide S1I86DO1-AT1-Angiotensin-like peptide S1I8
29.17Single7F1QMIP-1a7F1Q-CCR5-MIP-1a-Gi1/β1/γ2
29.17Single7WJ5Somatostatin-147WJ5-SST2-Somatostatin-14-Gi1/β1/γ2
29.17Single7XMSSomatostatin-147XMS-SST4-Somatostatin-14-Gi1/β1/γ2
29.17Single8JZZC5a-desArg8JZZ-C5a1-C5a-desArg-Go/β1/γ2
29.17Single8K6OPro-neuropeptide-Y8K6O-Y1-Pro-neuropeptide-Y-Gi2/β1/γ1
29.17Single8WSSPro-MCH8WSS-MCH1-Pro-MCH-Gi1/β1/γ1
29.17Consensuscompl-peptide_onOrthosteric Ligandc5a1_on c3a_on
29.17Consensusformylpeptide_on_gpOrthosteric Ligandfpr2-alx_on_gp fpr1-alx_on_gp
29.17Consensusgi_cckOrthosteric Ligand7EZH-CCKA-Cholecystokinin-8-Gi1/β1/γ2 7F8V-CCKB-Gastrin-17-Gi2/β1/γ2
29.17Consensussst4_onOrthosteric Ligand7XMS-SST4-Somatostatin-14-Gi1/β1/γ2 7XMT-SST4-J-2156-Gi1/β1/γ2
29.17Consensussst4_on_gpOrthosteric Ligand7XMS-SST4-Somatostatin-14-Gi1/β1/γ2 7XMT-SST4-J-2156-Gi1/β1/γ2
29.17Consensustachykinin_on_gpOrthosteric Ligandnk1_on_gp nk2_on_gp nk3_on_gp
28.57Single3VW7Vorapaxar; Na3VW7-PAR1-Vorapaxar; Na
28.57Single4GRVNeurotensin-(8-13)4GRV-NTS1-Neurotensin-(8-13)
28.57Single5MZJTheophylline5MZJ-A2A-Theophylline-Na
28.57Single6MXTSalmeterol6MXT-β2-Salmeterol
28.57Single6OS0Angiotensinogen6OS0-AT1-Angiotensinogen
28.57Single6OS2TRV0266OS2-AT1-TRV026
28.57Single6YVRNTS8-136YVR-NTS1-NTS8-13
28.57Single7XATSomatostatin-147XAT-SST2-Somatostatin-14-Gi1/β1/γ2
28.57Single8HK2C3a anaphylatoxin8HK2-C3aB-C3a anaphylatoxin-Gi1/β1/γ2
28.57Single8I9AEP548I9A-C3aB-EP54-chim(NtGi1-Gs-CtGq)/β1/γ2
28.57Single8IA8E7 peptide8IA8-C3aB-E7 peptide-Gi1/β1/γ2
28.57Single8IBUErythromycin-A8IBU-Motilin-Erythromycin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
28.57Single8ID9Eicosapentaenoic acid8ID9-FFA4-Eicosapentaenoic acid-Gi1/β1/γ2
28.57Single8JPBNeurotensin-(8-13)8JPB-NTS1-Neurotensin-(8-13)-PubChem 118610427; GDP; Mg-Gq; GRK2
28.57Single8PWNTheophylline8PWN-A2A-Theophylline
28.57Single8T3QDocosa-4,7,10,13,16,19-Hexaenoic acid8T3Q-FFA4-Docosa-4,7,10,13,16,19-Hexaenoic acid-chim(NtGi2L-Gs-CtGq)/β1/γ2
28.57Single8W1VPubChem 1717162658W1V-β2-PubChem 171716265
28.57Single8X8NOctreotide8X8N-SST5-Octreotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
28.57Single8XWSCXCL58XWS-CXCR2-CXCL5
28.57Consensusc3a_onOrthosteric Ligand8HK2-C3aB-C3a anaphylatoxin-Gi1/β1/γ2 8IA8-C3aB-E7 peptide-Gi1/β1/γ2
28.57Consensusgalanin_onOrthosteric Ligandgal2_on gal1_on
28.57Consensusgalanin_on_gpOrthosteric Ligandgal2_on_gp gal1_on_gp
28.57Consensusmotilin_on_gpOrthosteric Ligand8IBU-Motilin-Erythromycin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
28.12Single7X9ANeuropeptide-Y7X9A-Y1-Neuropeptide-Y-Gi1/β1/γ2
28.00Single7MBXCholecystokinin-87MBX-CCKA-Cholecystokinin-8-Gs/β1/γ1
28.00Single7T6TfMLFII7T6T-FPR1-ALX-fMLFII-Gi1/β1/γ2
28.00Single7XOUCholecystokinin-87XOU-CCKA-Cholecystokinin-8-Gs/β1/γ2
28.00Single8XIRPasireotide8XIR-SST3-Pasireotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
28.00Consensusangiotensin_onOrthosteric Ligandat1_on
28.00Consensusat1_onOrthosteric Ligand7F6G-AT1-SAR1-AngII-Gq/β1/γ2
28.00Consensuscompl-peptide_on_gpOrthosteric Ligandc5a1_on_gp c3a_on_gp
28.00Consensusgi_somatostatinOrthosteric Ligand7WIC-SST2-Somatostatin-14-Gi1/β1/γ2 7XMS-SST4-Somatostatin-14-Gi1/β1/γ2 8X8L-SST5-Cortistatin-chim(NtGi1-Gs-CtGi1)/β1/γ2 7XMT-SST4-J-2156-Gi1/β1/γ2 7WIG-SST2-L-054,264-Gi1/β1/γ2 8X8N-SST5-Octreotide-chim(NtGi1-Gs-CtGi1)/β1/γ2 7YAE-SST2-Octreotide-Gi1/β1/γ2 7YAC-SST2-Paltusotine-Gi1/β1/γ2
28.00Consensusgs_cckOrthosteric Ligand7MBX-CCKA-Cholecystokinin-8-Gs/β1/γ1
28.00Consensusgs_class-aOrthosteric Ligandgs_peptide gs_nucleotide gs_amine
28.00Consensuspeptide_offonOrthosteric Ligandpeptide_off peptide_on
27.78Single5IU4ZM-2413855IU4-A2A-ZM-241385-Na
27.78Single5IU7Q274563465IU7-A2A-Q27456346-Na
27.78Single5IUBQ274563445IUB-A2A-Q27456344-Na
27.78Single5JTBZM-2413855JTB-A2A-ZM-241385
27.78Single5K2BZM-2413855K2B-A2A-ZM-241385-Na
27.78Single5K2CZM-2413855K2C-A2A-ZM-241385-Na
27.78Single5NLXZM-2413855NLX-A2A-ZM-241385-Na
27.78Single5NM4ZM-2413855NM4-A2A-ZM-241385-Na
27.78Single5TE3Octyl-Beta-D-Glucopyranoside5TE3-Rhodopsin-Octyl-β-D-Glucopyranoside
27.78Single5UVIZM-2413855UVI-A2A-ZM-241385
27.78Single6ME32-Phenylmelatonin6ME3-MT1-2-Phenylmelatonin
27.78Single6MH8ZM-2413856MH8-A2A-ZM-241385
27.78Single6U1NLY21196206U1N-M2-LY2119620-Arrestin2
27.78Single6ZDRHMS1413f126ZDR-A2A-HMS1413f12-Na
27.78Single7BB6AVP7BB6-V2-AVP-Gs/β1/γ2
27.78Single7XOVSR1461317XOV-CCKA-SR146131-Gs/β1/γ2
27.78Single8RQQZM-2413858RQQ-A2A-ZM-241385-Na
27.78Single8RWCStilSwitch28RWC-A2A-StilSwitch2-Na
27.78Single8RWDStilSwitch38RWD-A2A-StilSwitch3-Na
27.78Consensusa2_offOrthosteric Liganda2a_off
27.78Consensusa2a_offOrthosteric Ligand3RFM-A2A-Caffeine 8C9W-A2A-Etrumadenant 3UZA-A2A-GTPL9236 8GNG-A2A-Istradefylline 8CU6-A2A-LJ-4517 7PX4-A2A-PSB-2113 7PYR-A2A-PSB-2115 8DU3-A2A-PubChem 105526064 8JWY-A2A-2-118 8PWN-A2A-Theophylline 5IU4-A2A-ZM-241385-Na 5OLZ-A2A-PubChem 135566609-Na 6GT3-A2A-Imaradenant-Na 5OLV-A2A-LUAA41063-Na 5N2R-A2A-PSB-36-Na 5IU7-A2A-Q27456346-Na 5OLH-A2A-Vipadenant-Na 5OLO-A2A-Tozadenant-Na 6ZDR-A2A-HMS1413f12-Na 8GNE-A2A-KW-6356-Na 8JWZ-A2A-AB928-Na 5IU8-A2A-Q27456347-Na 5IUB-A2A-Q27456344-Na 6ZDV-A2A-Chromone 5d-Na 5IUA-A2A-Q27456348-Na 8A2P-A2A-LUAA47070-Na
27.78Consensusadenosine_onOrthosteric Liganda1_on a2_on a3_on
27.78Consensusgi_adenosineOrthosteric Ligand7LD4-A1-Adenosine-Gi2/β1/γ2 8X17-A3A-Namodenoson-Gi1/β1/γ2 8X16-A3A-Piclidenoson-Gi1/β1/γ2
27.78Consensusgrh_offOrthosteric Ligandgnrh1_off
27.59Single7VGXNeuropeptide-Y7VGX-Y1-Neuropeptide-Y-Gi1/β1/γ2
27.59Single7VVJPTHrP(1-36)7VVJ-PTH1-PTHrP(1-36)-Gs/β1/γ2
27.59Single8IY6Endothelin-18IY6-ETB-Endothelin-1
27.59Single8Y52BA18Y52-BB3-BA1-chim(NtGi1-Gs-CtGq)/β1/γ2
27.59Consensusbk2_onOrthosteric Ligand7F6H-BK2-Bradykinin-Gq/β1/γ2 7F6I-BK2-Kallidin-Gq/β1/γ2
27.59Consensusbk2_on_gpOrthosteric Ligand7F6H-BK2-Bradykinin-Gq/β1/γ2 7F6I-BK2-Kallidin-Gq/β1/γ2
27.59Consensusbradykinin_onOrthosteric Ligandbk2_on
27.59Consensusbradykinin_on_gpOrthosteric Ligandbk2_on_gp
27.59Consensusgq_bradykininOrthosteric Ligand7F6H-BK2-Bradykinin-Gq/β1/γ2 7F6I-BK2-Kallidin-Gq/β1/γ2
27.27Single6BQGErgotamine6BQG-5-HT2C-Ergotamine
27.27Single7MBYCholecystokinin-87MBY-CCKA-Cholecystokinin-8-chim(NtGi1L-Gs-CtGq)/β1/γ2
27.27Single7P00Substance-P7P00-NK1-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
27.27Single8I95EP548I95-C3aB-EP54-Go/β1/γ2
27.27Single8JPFNeurotensin8JPF-NTS1-Neurotensin-PubChem 118610427
27.27Consensusc3a_on_gpOrthosteric Ligand8HK2-C3aB-C3a anaphylatoxin-Gi1/β1/γ2 8IA8-C3aB-E7 peptide-Gi1/β1/γ2
27.27Consensusclass-a_onOrthosteric Ligandsensory_on alicarboxylic_on amine_on lipid_on nucleotide_on peptide_on protein_on
27.27Consensusnk1_onOrthosteric Ligand7P00-NK1-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
27.27Consensusnk1_on_gpOrthosteric Ligand7P00-NK1-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
27.27Consensusnk2_onOrthosteric Ligand7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
26.92Single7DW9AVP7DW9-V2-AVP-chim(NtGi1-Gs)/β1/γ2
26.92Single7F6GSAR1-AngII7F6G-AT1-SAR1-AngII-Gq/β1/γ2
26.92Single7YONPeptide-YY(3-36)7YON-Y2-Peptide-YY(3-36)-Gi1/β1/γ2
26.92Single8WSTPro-MCH8WST-MCH2-Pro-MCH-chim(NtGi1L-Gs-CtGq)/β1/γ2
26.92Single9BKKCholecystokinin-89BKK-CCKA-Cholecystokinin-8-chim(NtGi1-Gs-CtGq)/β1/γ2
26.92Consensusangiotensin_on_gpOrthosteric Ligandat1_on_gp
26.92Consensusat1_on_gpOrthosteric Ligand7F6G-AT1-SAR1-AngII-Gq/β1/γ2
26.92Consensusgq_angiotensinOrthosteric Ligand7F6G-AT1-SAR1-AngII-Gq/β1/γ2
26.92Consensusgs_vasop-oxyOrthosteric Ligand7DW9-V2-AVP-chim(NtGi1-Gs)/β1/γ2
26.92Consensusprotein_offonOrthosteric Ligandprotein_off protein_on
26.92Consensusprotein_offon_gpOrthosteric Ligandprotein_on_gp protein_off
26.92Consensustachykinin_onOrthosteric Ligandnk1_on nk2_on nk3_on
26.92Consensusv2_onOrthosteric Ligand7DW9-V2-AVP-chim(NtGi1-Gs)/β1/γ2
26.92Consensusv2_on_gpOrthosteric Ligand7DW9-V2-AVP-chim(NtGi1-Gs)/β1/γ2
26.92Consensusvasop-oxy_onOrthosteric Ligandv2_on
26.92Consensusvasop-oxy_on_gpOrthosteric Ligandv2_on_gp
26.67Single5GLHEndothelin-15GLH-ETB-Endothelin-1
26.67Single6IGKEndothelin-36IGK-ETB-Endothelin-3
26.67Single8A2OTheophylline8A2O-A2A-Theophylline-Na
26.67Consensusccr5_on_gpOrthosteric Ligand7O7F-CCR5-6P4-CCL5-Gi1/β1/γ1 7F1Q-CCR5-MIP-1a-Gi1/β1/γ2
26.32Single3EMLZM-2413853EML-A2A-ZM-241385
26.32Single4EIYZM-2413854EIY-A2A-ZM-241385-Na
26.32Single4QIMANTA XV4QIM-SMO-ANTA XV
26.32Single4X1HNonyl-Beta-D-Glucopyranoside4X1H-Rhodopsin-Nonyl-β-D-Glucopyranoside-Gt(CT)
26.32Single5IU8Q274563475IU8-A2A-Q27456347-Na
26.32Single5K2AZM-2413855K2A-A2A-ZM-241385-Na
26.32Single5OLGZM-2413855OLG-A2A-ZM-241385-Na
26.32Single5T04Neurotensin5T04-NTS1-Neurotensin
26.32Single5VRAZM-2413855VRA-A2A-ZM-241385-Na
26.32Single6LPJZM-2413856LPJ-A2A-ZM-241385-Na
26.32Single6LPKZM-2413856LPK-A2A-ZM-241385-Na
26.32Single6S0LZM-2413856S0L-A2A-ZM-241385
26.32Single7DB6Ramelteon7DB6-MT1-Ramelteon-Gi1/β1/γ2
26.32Single7JOZVFP7JOZ-D1-VFP-Gs/β1/γ2
26.32Single7PYRPSB-21157PYR-A2A-PSB-2115
26.32Single7VGZRemalteon7VGZ-MT1-Remalteon-Gi1/β1/γ2
26.32Single8RW7StilSwitch18RW7-A2A-StilSwitch1-Na
26.32Single8X9TAP5038X9T-ADGRD1-AP503-chim(NtGi1-Gs)/β1/γ2
26.32Single8ZBEOctreotide8ZBE-SST5-Octreotide-Gi1/β1/γ1
26.32Single8ZQEGPR15L(C11)8ZQE-GPR15-GPR15L(C11)-Gi1/β1/γ1
26.32Single9CHXS-Carazolol9CHX-β2-S-Carazolol
26.32Consensusadenosine_on_gpOrthosteric Liganda1_on_gp a2_on_gp a3_on_gp
26.09Single6G79Donitriptan6G79-5-HT1B-Donitriptan-Go/β1/γ2
26.09Single7RMHSubstance-P7RMH-NK1-Substance-P-Gs/β1/γ2
26.09Single8QJ2pN1628QJ2-MC4-pN162-Gs
26.09Single8Z74Agonistic antibody8Z74-Apelin-Agonistic antibody
26.09Single8Z74Agonistic antibody8Z74-Apelin-Agonistic antibody
25.93Single7P02Protachykinin-17P02-NK1-Protachykinin-1-chim(NtGi1-Gs)/β1/γ2
25.93Single7Y64C5a anaphylatoxin7Y64-C5a1-C5a anaphylatoxin-Gi1/β1/γ2
25.93Single8WWKMCH8WWK-MCH1-MCH-Gi1/β1/γ2
25.93Single8XVIEndothelin-18XVI-ETA-Endothelin-1-chim(Gs-CtGq)/β1/γ2
25.93Consensuschemokine_on_gpOrthosteric Ligandccr_on_gp cxcr_on_gp
25.93Consensuscml1_on_gpOrthosteric Ligand7YKD-CML1-Chemerin-9-Gi1/β1/γ2
25.93Consensusopioid_onOrthosteric Ligandmop_on nop_on dop_on kop_on
25.81Single8FLSAbaloparatide8FLS-PTH1-Abaloparatide-Gs/β1/γ2
25.00Single4IARErgotamine4IAR-5-HT1B-Ergotamine
25.00Single4IB4Ergotamine4IB4-5-HT2B-Ergotamine
25.00Single4RWDDIPP-NH24RWD-δ-DIPP-NH2-Na
25.00Single4XNWMRS25004XNW-P2Y1-MRS2500
25.00Single5IUAQ274563485IUA-A2A-Q27456348-Na
25.00Single5NM2ZM-2413855NM2-A2A-ZM-241385-Na
25.00Single5WKTOctyl-Beta-D-Glucopyranoside5WKT-Rhodopsin-Octyl-β-D-Glucopyranoside-Gt(CT)
25.00Single6FJ3PTH6FJ3-PTH1-PTH
25.00Single6LFMInterleukin-86LFM-CXCR2-Interleukin-8-Gi1/β1/γ2
25.00Single6LPLZM-2413856LPL-A2A-ZM-241385-Na
25.00Single6LRYSarafotoxin-B6LRY-ETB-Sarafotoxin-B
25.00Single6ME5Agomelatine6ME5-MT1-Agomelatine
25.00Single6ME62-Phenylmelatonin6ME6-MT2-2-Phenylmelatonin
25.00Single6ME72-Phenylmelatonin6ME7-MT2-2-Phenylmelatonin
25.00Single6NBFLong-Acting PTH Analog6NBF-PTH1-Long-Acting PTH Analog-Gs/β1/γ2
25.00Single6NBILong-Acting PTH Analog6NBI-PTH1-Long-Acting PTH Analog-Gs/β1/γ2
25.00Single6S0QZM-2413856S0Q-A2A-ZM-241385
25.00Single6WQAZM-2413856WQA-A2A-ZM-241385-Na
25.00Single7C61Ergotamine7C61-5-HT1B-Ergotamine
25.00Single7CKXA776367CKX-D1-A77636-Gs/β1/γ2
25.00Single7F8VGastrin-177F8V-CCKB-Gastrin-17-Gi2/β1/γ2
25.00Single7KI0Semaglutide7KI0-GLP-1-Semaglutide-Gs/β1/γ2
25.00Single7RM5ZM-2413857RM5-A2A-ZM-241385-Na
25.00Single7VFXfMLF7VFX-FPR1-ALX-fMLF-Gi1/β1/γ2
25.00Single7VUHJNJ-635330547VUH-GPR139-JNJ-63533054-chim(Gs-CtGq)/β1/γ2
25.00Single7VVMPTH7VVM-PTH1-PTH-Gs/β1/γ2
25.00Single7W3ZGastrin Releasing Peptide7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/β1/γ2
25.00Single7WIGL-054,2647WIG-SST2-L-054,264-Gi1/β1/γ2
25.00Single7WVWfMYFINILTL7WVW-FPR2-ALX-fMYFINILTL-Gi2/β1/γ2
25.00Single7X1TTaltirelin7X1T-TRH-Taltirelin-chim(NtGi2L-Gs-CtGq)/β1/γ2
25.00Single7YKDChemerin-97YKD-CML1-Chemerin-9-Gi1/β1/γ2
25.00Single8E3XPACAP278E3X-PAC1-PACAP27-Gs/β1/γ2
25.00Single8F7XNociceptin8F7X-NOP-Nociceptin-Gi1/β1/γ2
25.00Single8FLRPTHrP(1-36)8FLR-PTH1-PTHrP(1-36)-Gs/β1/γ2
25.00Single8FYNZM-2413858FYN-A2A-ZM-241385-Na
25.00Single8ID4Linoleic acid8ID4-FFA4-Linoleic acid-Gi1/β1/γ2
25.00Single8K3ZCXCL128K3Z-CXCR4-CXCL12-Gi1/β1/γ1
25.00Single8QOTNanobody-E8QOT-μ-Nanobody-E
25.00Single8XGMChemerin8XGM-CML2-Chemerin-Gi1/β1/γ2
25.00Single8XQFApelin-138XQF-Apelin-Apelin-13-Gi1/β1/γ2
25.00Single9IV15alpha-DHT9IV1-ADGRD1-5α-DHT-chim(NtGi1-Gs)/β1/γ2
25.00Consensusa1_offOrthosteric Ligand5UEN-A1-DU172 5N2S-A1-PSB36
25.00Consensusadenosine_offOrthosteric Liganda1_off a2_off
25.00Consensusccr5_onOrthosteric Ligand7O7F-CCR5-6P4-CCL5-Gi1/β1/γ1 7F1Q-CCR5-MIP-1a-Gi1/β1/γ2
25.00Consensuscxcr2_on_gpOrthosteric Ligand6LFM-CXCR2-Interleukin-8-Gi1/β1/γ2
25.00Consensuscxcr4_onOrthosteric Ligand8K3Z-CXCR4-CXCL12-Gi1/β1/γ1
25.00Consensusd1_onOrthosteric Ligand7F0T-D1-Dopamine-Gs/β1/γ2 7CKY-D1-PW0464-Gs/β1/γ2 8IRR-D1-Rotigotine-Gs/β1/γ2 7JV5-D1-SKF81297-Gs/β1/γ2 7JVP-D1-SKF83959-Gs/β1/γ2 7X2D-D1-Tavapadon-Gs/β1/γ2 7CKX-D1-A77636-Gs/β1/γ2 7JVQ-D1-Apomorphine-Gs/β1/γ2 7CKW-D1-Fenoldopam-Gs/β1/γ2
25.00Consensusfpr1-alx_onOrthosteric Ligand7VFX-FPR1-ALX-fMLF-Gi1/β1/γ2
25.00Consensusfpr1-alx_on_gpOrthosteric Ligand7VFX-FPR1-ALX-fMLF-Gi1/β1/γ2
25.00Consensusgi_compl-peptOrthosteric Ligand8HK5-C5a1-Complement C5-Gi1/β1/γ2 8IA8-C3aB-E7 peptide-Gi1/β1/γ2 7Y66-C5a1-BM213-Gi1/β1/γ2 7Y67-C5a1-C089 peptide-Gi1/β1/γ2 8HK2-C3aB-C3a anaphylatoxin-Gi1/β1/γ2 7Y64-C5a1-C5a anaphylatoxin-Gi1/β1/γ2
25.00Consensusgi_nucleotideOrthosteric Ligandgi_adenosine gi_p2y
25.00Consensusgs_amineOrthosteric Ligandgs_5ht gs_adrenergic gs_dopamine gs_histamine gs_trace-amine
25.00Consensusgs_peptideOrthosteric Ligandgs_cck gs_melanocortin gs_vasop-oxy
25.00Consensusmop_offOrthosteric Ligand4DKL-μ-β-Funaltrexamine 8QOT-μ-Nanobody-E 7UL4-μ-Alvimopan
25.00Consensusnucleotide_onOrthosteric Ligandadenosine_on p2y_on
25.00Consensusopioid_on_gpOrthosteric Ligandmop_on_gp nop_on_gp dop_on_gp kop_on_gp
25.00Consensusp2y1_offOrthosteric Ligand4XNW-P2Y1-MRS2500
25.00Consensusp2y_onOrthosteric Ligandp2y1_on p2y10_on p2y12_on
25.00Consensussst5_onOrthosteric Ligand8X8L-SST5-Cortistatin-chim(NtGi1-Gs-CtGi1)/β1/γ2 8X8N-SST5-Octreotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
24.24Single7Y36Teriparatide7Y36-PTH1-Teriparatide-Gs/β1/γ2
24.24Single8FLQPTH8FLQ-PTH1-PTH-Gs/β1/γ2
24.14Single6VCBGLP-16VCB-GLP-1-GLP-1-LSN3160440-Gs/β1/γ2
24.14Single7EIBDes-Arg10-Kallidin7EIB-BK1-Des-Arg10-Kallidin-chim(NtGi1-Gs-CtGq)/β1/γ2
24.14Single8FEG(DNCP)-Beta-Naloxamine8FEG-κ-(DNCP)-β-Naloxamine-Gi1/β1/γ2
24.14Single8WWLMCH8WWL-MCH1-MCH-Gi1/β1/γ2
24.14Single8ZH8QRF-Amide8ZH8-QRFP-QRF-Amide-Gq/β1/γ1
24.14Single8ZJGChemerin8ZJG-CML1-Chemerin-Gi1/β1/γ2
24.00Single7RMISubstance-P7RMI-NK1-Substance-P-chim(Gs-CtGq)/β1/γ2
24.00Single7VBINon-Acylated Tirzepatide7VBI-GLP-1-Non-Acylated Tirzepatide-Gs/β1/γ2
24.00Single7XNACYN1548067XNA-SST2-CYN154806
24.00Single8JBHSubstance-P8JBH-NK3-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
24.00Single8SG1Chemerin-98SG1-CML1-Chemerin-9-Gi1/β1/γ2
24.00Consensuscckb_onOrthosteric Ligand8IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/β1/γ2 7XOW-CCKB-Gastrin-chim(NtGi1-Gq)/β1/γ2 7F8V-CCKB-Gastrin-17-Gi2/β1/γ2
24.00Consensusgq_class-aOrthosteric Ligandgq_peptide gq_amine gq_nucleotide
24.00Consensussst2_offOrthosteric Ligand7XNA-SST2-CYN154806
23.81Single5A8E7-Methylcyanopindolol5A8E-β1-7-Methylcyanopindolol-Na
23.81Single5V56TC1145V56-SMO-TC114
23.81Single5ZBHBMS-1938855ZBH-Y1-BMS-193885
23.81Single6J21Aprepitant6J21-NK1-Aprepitant
23.81Single6O3CCholesterol6O3C-SMO-SAG21k-Cholesterol
23.81Single6WGTLSD6WGT-5-HT2A-LSD
23.81Single6Z8NSRI-98296Z8N-NTS1-SRI-9829
23.81Single7CKYPW04647CKY-D1-PW0464-Gs/β1/γ2
23.81Single7JV5SKF812977JV5-D1-SKF81297-Gs/β1/γ2
23.81Single7JVPSKF839597JVP-D1-SKF83959-Gs/β1/γ2
23.81Single7R0CAVP7R0C-V2-AVP-Arrestin2
23.81Single7SK7CXCL127SK7-ACKR3-CXCL12-CCX662
23.81Single7XAVLanreotide7XAV-SST2-Lanreotide-Gi1/β1/γ2
23.81Single7XBDGalanin7XBD-GAL2-Galanin-chim(NtGi2L-Gs-CtGq)/β1/γ2
23.81Single7XWONeurokinin-A7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
23.81Single7XY7NECA7XY7-A2B-NECA-chim(NtGi1-Gs)/β1/γ2
23.81Single8HQCC5a anaphylatoxin8HQC-C5a1-C5a anaphylatoxin-Go/β1/γ2
23.81Single8JBGNeurokinin-B8JBG-NK3-Neurokinin-B-chim(NtGi1-Gs-CtGq)/β1/γ2
23.81Single8JXVClozapine8JXV-H4-Clozapine-Gi1/β1/γ2
23.81Single8JZPC5A anaphylatoxin8JZP-C5a1-C5A anaphylatoxin-Go/β1/γ2
23.81Single8X16Piclidenoson8X16-A3A-Piclidenoson-Gi1/β1/γ2
23.81Single8XIPPasireotide8XIP-SST1-Pasireotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
23.81Single8XX7CXCL58XX7-CXCR2-CXCL5-Go/β1/γ2
23.81Consensusa2_onOrthosteric Liganda2b_on
23.81Consensusa2_on_gpOrthosteric Liganda2b_on_gp
23.81Consensusa2b_onOrthosteric Ligand8HDP-A2B-Adenosine-Gs/β1/γ2 7XY6-A2B-BAY 60-6583-chim(NtGi1-Gs)/β1/γ2 7XY7-A2B-NECA-chim(NtGi1-Gs)/β1/γ2 8HDO-A2B-BAY 60-6583-Gs/β1/γ2
23.81Consensusa2b_on_gpOrthosteric Ligand8HDP-A2B-Adenosine-Gs/β1/γ2 7XY6-A2B-BAY 60-6583-chim(NtGi1-Gs)/β1/γ2 7XY7-A2B-NECA-chim(NtGi1-Gs)/β1/γ2 8HDO-A2B-BAY 60-6583-Gs/β1/γ2
23.81Consensusclass-a_offOrthosteric Ligandsensory_off alicarboxylic_off amine_off lipid_off nucleotide_off peptide_off protein_off
23.81Consensusd1_on_gpOrthosteric Ligand7F0T-D1-Dopamine-Gs/β1/γ2 7CKY-D1-PW0464-Gs/β1/γ2 8IRR-D1-Rotigotine-Gs/β1/γ2 7JV5-D1-SKF81297-Gs/β1/γ2 7JVP-D1-SKF83959-Gs/β1/γ2 7X2D-D1-Tavapadon-Gs/β1/γ2 7CKX-D1-A77636-Gs/β1/γ2 7JVQ-D1-Apomorphine-Gs/β1/γ2 7CKW-D1-Fenoldopam-Gs/β1/γ2
23.81Consensusgi_dopamineOrthosteric Ligand7JVR-D2-Bromoergocryptine-Gi1/β1/γ2 7CMV-D3-PD128907-Gi1/β1/γ2 7CMU-D3-Pramipexole-Gi1/β1/γ2 8IRS-D2-Rotigotine-Gi1/β1/γ2 8IRT-D3-Rotigotine-Gi1/β1/γ2
23.81Consensusgs_adenosineOrthosteric Ligand8HDP-A2B-Adenosine-Gs/β1/γ2 8HDO-A2B-BAY 60-6583-Gs/β1/γ2 7XY7-A2B-NECA-chim(NtGi1-Gs)/β1/γ2 7XY6-A2B-BAY 60-6583-chim(NtGi1-Gs)/β1/γ2
23.81Consensusgs_dopamineOrthosteric Ligand7F0T-D1-Dopamine-Gs/β1/γ2 7CKW-D1-Fenoldopam-Gs/β1/γ2 7CKY-D1-PW0464-Gs/β1/γ2 8IRV-D5-Rotigotine-chim(NtGi1-Gs)/β1/γ2 8IRR-D1-Rotigotine-Gs/β1/γ2 7JV5-D1-SKF81297-Gs/β1/γ2 7JVP-D1-SKF83959-Gs/β1/γ2 7X2D-D1-Tavapadon-Gs/β1/γ2 7CKX-D1-A77636-Gs/β1/γ2 7JVQ-D1-Apomorphine-Gs/β1/γ2
23.81Consensusgs_nucleotideOrthosteric Ligandgs_adenosine
23.81Consensusnk2_on_gpOrthosteric Ligand7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
23.81Consensusnpy1_offOrthosteric Ligand5ZBH-Y1-BMS-193885 5ZBQ-Y1-UR-MK-299
23.53Single3VGAZM-2413853VGA-A2A-ZM-241385-Antibody
23.53Single4O9RCyclopamine4O9R-SMO-Cyclopamine
23.53Single7D76Beclomethasone7D76-ADGRG3-Beclomethasone-Go/β1/γ2
23.53Single7VUIJNJ-635330547VUI-GPR139-JNJ-63533054-GTP-chim(Gs-CtGq)/β1/γ2
23.53Single7XTASerotonin7XTA-5-HT4-Serotonin-Gi1/β1/γ2
23.53Single7YS6Serotonin7YS6-5-HT6-Serotonin-chim(NtGi1-Gs)/β1/γ2
23.53Single8A2PLUAA470708A2P-A2A-LUAA47070-Na
23.53Single8RWHStilSwitch28RWH-A2A-StilSwitch2-Na
23.53Single8U4RREGN7663-Fab8U4R-CXCR4-REGN7663-Fab-Cholesterol
23.53Single9IQTNiacin9IQT-HCA2-Niacin-Gi1/β1/γ2
23.53Consensus5ht4_onOrthosteric Ligand7XTA-5-HT4-Serotonin-Gi1/β1/γ2
23.53Consensus5ht4_on_gpOrthosteric Ligand7XTA-5-HT4-Serotonin-Gi1/β1/γ2
23.33Single6IGLIRL16206IGL-ETB-IRL1620
23.33Single6LMKGlucagon6LMK-Glucagon-Glucagon-Gs/β1/γ2
23.33Single6NBHLong-Acting PTH Analog6NBH-PTH1-Long-Acting PTH Analog-Gs/β1/γ2
23.33Single8FLTM-PTH(1-14)8FLT-PTH1-M-PTH(1-14)-Gs/β1/γ2
23.33Single8IY5Endothelin-18IY5-ETB-Endothelin-1-Gi1/β1/γ2
23.33Single8WWNMCH8WWN-MCH1-MCH-Gi1/β1/γ2
23.33Consensusendothelin_onOrthosteric Ligandetb_on eta_on
23.08Single6LW5WKYMVm6LW5-FPR2-ALX-WKYMVm
23.08Single6MEOEnvelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd46MEO-CCR5-Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4
23.08Single7RYCOxytocin7RYC-OT-Oxytocin-chim(NtGi2L-Gs-CtGq)/β1/γ2
23.08Single7TD2LPA7TD2-LPA1-LPA-Gi1/β1/γ2
23.08Consensuscckb_on_gpOrthosteric Ligand8IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/β1/γ2 7XOW-CCKB-Gastrin-chim(NtGi1-Gq)/β1/γ2 7F8V-CCKB-Gastrin-17-Gi2/β1/γ2
23.08Consensuscxcr4_on_gpOrthosteric Ligand8K3Z-CXCR4-CXCL12-Gi1/β1/γ1
22.73Single4AMIBucindolol4AMI-β1-Bucindolol
22.73Single4N4WSANT-14N4W-SMO-SANT-1
22.73Single4RWADIPP-NH24RWA-δ-DIPP-NH2
22.73Single6VMSBromoergocryptine6VMS-D2-Bromoergocryptine-Gi1/β1/γ2
22.73Single6W2YPubChem 237279706W2Y-GABAB1; GABAB1-PubChem 5311042-PubChem 23727970
22.73Single6XBLCholesterol6XBL-SMO-SAG-Cholesterol-Gi1/β1/γ2
22.73Single7DH5Mirabegron7DH5-β3-Mirabegron-Gs/β1/γ2
22.73Single7EVYSiponimod7EVY-S1P1-Siponimod-Gi1/β1/γ2
22.73Single7EXDLasmiditan7EXD-5-HT1F-Lasmiditan-Gi1/β1/γ2
22.73Single7XJKGalanin7XJK-GAL2-Galanin-chim(NtGi2L-Gs-CtGq)/β1/γ2
22.73Single7XMTJ-21567XMT-SST4-J-2156-Gi1/β1/γ2
22.73Single7XW9TRH7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/β1/γ2
22.73Single7Y66BM2137Y66-C5a1-BM213-Gi1/β1/γ2
22.73Single8G056-OAU8G05-GPR84-6-OAU-Gi1/β1/γ2
22.73Single8J6DEP1418J6D-C3aB-EP141-Go/β1/γ2
22.73Single8JJLOlodaterol8JJL-β2-Olodaterol
22.73Single8JJPChemerin8JJP-CML2-Chemerin-Gi1/β1/γ2
22.73Single8JWY2-1188JWY-A2A-2-118
22.73Single8XQJJN2418XQJ-Apelin-JN241
22.73Single8XWACXCL18XWA-CXCR2-CXCL1
22.73Single8XWMCXCL68XWM-CXCR2-CXCL6
22.73Single9GYOP3959GYO-GPBA-P395-chim(NtGi1-Gs)/β1/γ2
22.73Consensus5ht1f_onOrthosteric Ligand7EXD-5-HT1F-Lasmiditan-Gi1/β1/γ2
22.73Consensus5ht1f_on_gpOrthosteric Ligand7EXD-5-HT1F-Lasmiditan-Gi1/β1/γ2
22.73Consensuscannabinoid_offOrthosteric Ligandcb2_off cb1_off
22.73Consensusccr8_onOrthosteric Ligand8KFX-CCR8-LMD-009-Gi1/β1/γ2 8KFY-CCR8-ZK-756326-Gi1/β1/γ2 8U1U-CCR8-CCL1-Gi1/β1/γ2
22.73Consensuscxcr_onOrthosteric Ligandcxcr3_on cxcr4_on cxcr1_on cxcr2_on
22.73Consensusd2_on_gpOrthosteric Ligand7JVR-D2-Bromoergocryptine-Gi1/β1/γ2 8IRS-D2-Rotigotine-Gi1/β1/γ2
22.73Consensusgi_lipidOrthosteric Ligandgi_cannabinoid gi_ffa gi_leukotriene gi_lpa gi_s1p
22.73Consensusm4_onOrthosteric Ligand7TRS-M4-Acetylcholine-Gi1/β1/γ2 7V6A-M4-PubChem 9864275-Gi1/β1/γ2 8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/β1/γ2 7TRK-M4-Iperoxo-Gi1/β1/γ2
22.73Consensusm4_on_gpOrthosteric Ligand7TRS-M4-Acetylcholine-Gi1/β1/γ2 7V6A-M4-PubChem 9864275-Gi1/β1/γ2 8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/β1/γ2 7TRK-M4-Iperoxo-Gi1/β1/γ2
22.73Consensuss1p1_onOrthosteric Ligand7VIE-S1P1-S1P-Gi1/β1/γ2 7VIF-S1P1-S-FTY720-P-Gi1/β1/γ2 7VIG-S1P1-CBP-307-Gi1/β1/γ2 7EVY-S1P1-Siponimod-Gi1/β1/γ2 7EVZ-S1P1-Cenerimod-Gi1/β1/γ2 7EW0-S1P1-Ozanimod-Gi1/β1/γ2 7EW7-S1P1-SEW2871-Gi1/β1/γ2
22.73Consensuss1p1_on_gpOrthosteric Ligand7VIE-S1P1-S1P-Gi1/β1/γ2 7VIF-S1P1-S-FTY720-P-Gi1/β1/γ2 7VIG-S1P1-CBP-307-Gi1/β1/γ2 7EVY-S1P1-Siponimod-Gi1/β1/γ2 7EVZ-S1P1-Cenerimod-Gi1/β1/γ2 7EW0-S1P1-Ozanimod-Gi1/β1/γ2 7EW7-S1P1-SEW2871-Gi1/β1/γ2
22.73Consensustrh_onOrthosteric Ligand7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/β1/γ2
22.73Consensustrh_on_gpOrthosteric Ligand7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/β1/γ2
22.58Single7DUQGLP-17DUQ-GLP-1-GLP-1-PubChem 156022738-Gs/β1/γ2
22.58Consensusbb2_onOrthosteric Ligand7W40-BB2-Bombesin-chim(NtGi1L-Gq)/β1/γ2 7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/β1/γ2
22.58Consensusbb2_on_gpOrthosteric Ligand7W40-BB2-Bombesin-chim(NtGi1L-Gq)/β1/γ2 7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/β1/γ2
22.58Consensusbombesin_onOrthosteric Ligandbb2_on
22.58Consensusbombesin_on_gpOrthosteric Ligandbb2_on_gp
22.58Consensusgq_bombesinOrthosteric Ligand7W40-BB2-Bombesin-chim(NtGi1L-Gq)/β1/γ2 7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/β1/γ2
22.22Single3PWHZM-2413853PWH-A2A-ZM-241385
22.22Single4BWBNeurotensin4BWB-NTS1-Neurotensin
22.22Single4MQTLY21196204MQT-M2-Iperoxo-LY2119620
22.22Single4QINSAG1.54QIN-SMO-SAG1.5
22.22Single5OLVLUAA410635OLV-A2A-LUAA41063-Na
22.22Single5WB2CX3CL1.355WB2-US28-CX3CL1.35
22.22Single6JODAngiotensin II6JOD-AT2-Angiotensin II
22.22Single6LFOInterleukin-86LFO-CXCR2-Interleukin-8-Gi1/β1/γ2
22.22Single6ME2Ramelteon6ME2-MT1-Ramelteon
22.22Single6ME9Ramelteon6ME9-MT2-Ramelteon
22.22Single6METEnvelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd46MET-CCR5-Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4
22.22Single6O3CSAG21k6O3C-SMO-SAG21k-Cholesterol
22.22Single7BR3Elagolix7BR3-GnRH1-Elagolix
22.22Single7F1ODopamine7F1O-D1-Dopamine-GDP; Mg-Gs/β1/γ2
22.22Single7F8ULintitript7F8U-CCKA-Lintitript
22.22Single7VV5C48/807VV5-MRGPRX2-C48/80-Gi1/β1/γ2
22.22Single7W40Bombesin7W40-BB2-Bombesin-chim(NtGi1L-Gq)/β1/γ2
22.22Single7W57Neuromedin-S7W57-NMUR2-Neuromedin-S-chim(NtGi1-Gs-CtGq)/β1/γ2
22.22Single7X5H5-CT7X5H-5-HT5A-5-CT-Gi1/β1/γ2
22.22Single7XJJGalanin7XJJ-GAL1-Galanin-Go/β1/γ2
22.22Single8DU3PubChem 1055260648DU3-A2A-PubChem 105526064
22.22Single8GGZConstrained Epinephrine8GGZ-β2-Constrained Epinephrine
22.22Single8H4KGW95088H4K-FFA4-GW9508-chim(NtGi1-Gs-CtGq)/β1/γ2
22.22Single8H8JLodoxamide8H8J-GPR35-Lodoxamide-Ca-chim(NtGi1L-G13)/β1/γ2
22.22Single8IEDA1LYA8IED-GPR156-A1LYA-Go/β1/γ2
22.22Single8IJBAcipimox8IJB-HCA2-Acipimox-Gi1/β1/γ2
22.22Single8IW4Spermidine8IW4-TA9-Spermidine-chim(NtGi1-Gs)/β1/γ2
22.22Single8IWESpermidine8IWE-TA9-Spermidine
22.22Single8RW0Istradefylline8RW0-A2A-Istradefylline-Na
22.22Single8UNSConstrained Epinephrine8UNS-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
22.22Single8UNTConstrained Epinephrine8UNT-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
22.22Single8UNXConstrained Epinephrine8UNX-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
22.22Single8X8LCortistatin8X8L-SST5-Cortistatin-chim(NtGi1-Gs-CtGi1)/β1/γ2
22.22Single8XXXCXCL68XXX-CXCR2-CXCL6-Go/β1/γ2
22.22Single8XZJWN3538XZJ-Apelin-WN353-Gi1/β1/γ2
22.22Consensus5ht1e_onOrthosteric Ligand7E33-5-HT1E-BRL-54443-Gi1/β1/γ2 8UGY-5-HT1E-Mianserin-Gi1/β1/γ1 8UH3-5-HT1E-Setiptiline-Gi1/β1/γ1
22.22Consensus5ht_onOrthosteric Ligand5ht1_on 5ht2_on 5ht4_on 5ht5_on 5ht6_on 5ht7_on
22.22Consensusalpha2_offOrthosteric Ligandalpha2c_off
22.22Consensuscxcr1_onOrthosteric Ligand8IC0-CXCR1-Interleukin-8-Gi1/β1/γ2
22.22Consensuscxcr3_on_gpOrthosteric Ligand8HNK-CXCR3-CXCL11-Gi1/β1/γ2 8HNL-CXCR3-PS372424-Gi1/β1/γ2
22.22Consensusgi_formylpeptideOrthosteric Ligand7WVY-FPR2-ALX-Amyloid-β42-Gi2/β1/γ2 7T6U-FPR2-ALX-CGEN-855A-Gi1/β1/γ2 7VFX-FPR1-ALX-fMLF-Gi1/β1/γ2 7T6V-FPR2-ALX-fMLFII-Gi1/β1/γ2 7WVX-FPR2-ALX-Humanin-Gi2/β1/γ2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/β1/γ2 6OMM-FPR2-ALX-WKYMVX-Gi1/β1/γ2
22.22Consensusgnrh1_offOrthosteric Ligand7BR3-GnRH1-Elagolix
22.22Consensusgs_5htOrthosteric Ligand7XTC-5-HT7-5-CT-Gs/β1/γ2 7XTB-5-HT6-Serotonin-Gs/β1/γ2 8JLZ-5-HT6-ST1936-Gs/β1/γ2 7XT8-5-HT4-Serotonin-Gs/β1/γ2
22.22Consensusp2y1_onOrthosteric Ligand7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/β1/γ2
22.22Consensusp2y_on_gpOrthosteric Ligandp2y1_on_gp p2y10_on_gp p2y12_on_gp
21.88Single7SK6CXCL12_LRHQ7SK6-ACKR3-CXCL12_LRHQ
21.88Consensusendothelin_on_gpOrthosteric Ligandetb_on_gp eta_on_gp
21.74Single2YCZIodocyanopindolol2YCZ-β1-Iodocyanopindolol
21.74Single4BVNCyanopindolol4BVN-β1-Cyanopindolol-Na
21.74Single4NC3Ergotamine4NC3-5-HT2B-Ergotamine
21.74Single5TUDErgotamine5TUD-5-HT2B-Ergotamine
21.74Single6IBLArformoterol6IBL-β1-Arformoterol
21.74Single6TKOArformoterol6TKO-β1-Arformoterol-Arrestin2
21.74Single7EVZCenerimod7EVZ-S1P1-Cenerimod-Gi1/β1/γ2
21.74Single7EW0Ozanimod7EW0-S1P1-Ozanimod-Gi1/β1/γ2
21.74Single7QVMOxytocin7QVM-OT-Oxytocin-chim(NtGi1-Go-CtGq)/β1/γ2
21.74Single7Y65C5a peptide7Y65-C5a1-C5a peptide-Gi1/β1/γ2
21.74Single8E9X2-Deoxycytidine8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/β1/γ2
21.74Single8FX5Xanomeline8FX5-M4-Xanomeline-Xanomeline-Gi1/β1/γ2
21.74Single8ID8TUG-8918ID8-FFA4-TUG-891-Gi1/β1/γ2
21.74Single8IYSTUG-8918IYS-FFA4-TUG-891-GDP-chim(NtGi1L-Gq)/β1/γ2
21.74Single8J19LY2378J19-GPR84-LY237-Gi1/β1/γ2
21.74Single8K4OCXCL18K4O-KSHV-CXCL1-Gi1/β1/γ1
21.74Single8XGSMetastin8XGS-Kiss1-Metastin-chim(NtGi1-Gq)/β1/γ2
21.74Single8XIOL7975918XIO-SST1-L797591-chim(NtGi1-Gs-CtGi1)/β1/γ2
21.74Single8XVUCXCL28XVU-CXCR2-CXCL2
21.74Single8XWFCXCL38XWF-CXCR2-CXCL3
21.74Single8XWVCXCL18XWV-CXCR2-CXCL1-Go/β1/γ2
21.74Single8XXHCXCL28XXH-CXCR2-CXCL2-Go/β1/γ2
21.74Single8ZX4Lysophosphatidylinositol 8ZX4-GPR55-Lysophosphatidylinositol-chim(NtGi1-G13)/β1/γ2
21.74Single9GE3Lysophosphatidylinositol9GE3-GPR55-Lysophosphatidylinositol-chim(CtGi1-G13)/β1/γ2
21.74Single9IZFNKP9IZF-LPA1-NKP-Gi1/β1/γ2
21.74Consensusgal2_onOrthosteric Ligand7WQ4-GAL2-Galanin-chim(NtGi1-Gs-CtGq)/β1/γ2 7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/β1/γ2
21.74Consensusgal2_on_gpOrthosteric Ligand7WQ4-GAL2-Galanin-chim(NtGi1-Gs-CtGq)/β1/γ2 7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/β1/γ2
21.74Consensusgi_s1pOrthosteric Ligand7VIE-S1P1-S1P-Gi1/β1/γ2 7EW3-S1P3-S1P-Gi1/β1/γ2 7EVY-S1P1-Siponimod-Gi1/β1/γ2 7EW1-S1P5-Siponimod-Gi1/β1/γ2 7VIF-S1P1-S-FTY720-P-Gi1/β1/γ2 7VIG-S1P1-CBP-307-Gi1/β1/γ2 7EVZ-S1P1-Cenerimod-Gi1/β1/γ2 7EW4-S1P3-CYM5541-Gi1/β1/γ2 7EW2-S1P3-Fingolimod-Gi1/β1/γ2 7EW0-S1P1-Ozanimod-Gi1/β1/γ2 7EW7-S1P1-SEW2871-Gi1/β1/γ2
21.74Consensusnucleotide_on_gpOrthosteric Ligandadenosine_on_gp p2y_on_gp
21.74Consensuspeptide_offOrthosteric Ligandcck_off angiotensin_off bombesin_off endothelin_off ghrelin_off npy_off opioid_off orexin_off somatostatin_off tachykinin_off vasop-oxy_off neurotensin_off
21.43Single5MZPCaffeine5MZP-A2A-Caffeine-Na
21.43Single5YQZGlucagon analogue5YQZ-Glucagon-Glucagon analogue
21.43Single6X18GLP-16X18-GLP-1-GLP-1-Gs/β1/γ2
21.43Single7LLYOxyntomodulin7LLY-GLP-1-Oxyntomodulin-Gs/β1/γ2
21.43Single7X9CPancreatic Hormone7X9C-Y4-Pancreatic Hormone-Gi1/β1/γ2
21.43Single8HCQEndothelin-18HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/β1/γ2
21.43Single8HCXEndothelin-18HCX-ETB-Endothelin-1-chim(NtGi2L-Gs-CtGq)/β1/γ2
21.43Single8HK5Complement C58HK5-C5a1-Complement C5-Gi1/β1/γ2
21.43Single8HNKCXCL118HNK-CXCR3-CXCL11-Gi1/β1/γ2
21.43Single8IA2C5a anaphylatoxin8IA2-C5a1-C5a anaphylatoxin-Go/β1/γ2
21.43Single8WWMMCH8WWM-MCH1-MCH-Gi1/β1/γ2
21.43Single8XGOTAK4488XGO-Kiss1-TAK448-chim(NtGi1-Gq)/β1/γ2
21.43Single8XQEApelin-138XQE-Apelin-Apelin-13-Gi1/β1/γ2
21.43Single8XVHEndothelin-18XVH-ETB-Endothelin-1-chim(Gs-CtGq)/β1/γ2
21.43Consensuseta_onOrthosteric Ligand8HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/β1/γ2
21.43Consensuseta_on_gpOrthosteric Ligand8HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/β1/γ2
21.43Consensusgi_apelinOrthosteric Ligand8XZH-Apelin-MM07-Gi1/β1/γ2 7W0M-Apelin-PubChem 122701908-Gi1/β1/γ2 8XZJ-Apelin-WN353-Gi1/β1/γ2 8XZF-Apelin-WN561-Gi1/β1/γ2 8XZG-Apelin-Apelin-13-Gi1/β1/γ2
21.43Consensusgi_chemokineOrthosteric Ligand6WWZ-CCR6-CCL20-Go/β1/γ2 8HNK-CXCR3-CXCL11-Gi1/β1/γ2 8K3Z-CXCR4-CXCL12-Gi1/β1/γ1 8IC0-CXCR1-Interleukin-8-Gi1/β1/γ2 6LFM-CXCR2-Interleukin-8-Gi1/β1/γ2 8KFX-CCR8-LMD-009-Gi1/β1/γ2 7F1Q-CCR5-MIP-1a-Gi1/β1/γ2 8HNL-CXCR3-PS372424-Gi1/β1/γ2 8KFY-CCR8-ZK-756326-Gi1/β1/γ2 7O7F-CCR5-6P4-CCL5-Gi1/β1/γ1 8U1U-CCR8-CCL1-Gi1/β1/γ2 7VLA-CCR1-CCL15(27-92)-Gi1/β1/γ2 7XA3-CCR2-CCL2-Gi1/β1/γ2
21.05Single4LDOL-Epinephrine4LDO-β2-L-Epinephrine
21.05Single4N6HNaltrindole4N6H-δ-Naltrindole-Na
21.05Single6AQFZM-2413856AQF-A2A-ZM-241385
21.05Single6ME42-Iodomelatonin6ME4-MT1-2-Iodomelatonin
21.05Single6PS0S-Carazolol6PS0-β2-S-Carazolol
21.05Single6PS4ICI118-5516PS4-β2-ICI118-551
21.05Single6PS5S-Propranolol6PS5-β2-S-Propranolol
21.05Single6PS82-Phenylmelatonin6PS8-MT1-2-Phenylmelatonin
21.05Single6XBLSAG6XBL-SMO-SAG-Cholesterol-Gi1/β1/γ2
21.05Single6ZDVChromone 5d6ZDV-A2A-Chromone 5d-Na
21.05Single7AROLUF58337ARO-A2A-LUF5833-Na
21.05Single7CKWFenoldopam7CKW-D1-Fenoldopam-Gs/β1/γ2
21.05Single7CKZDopamine7CKZ-D1-Dopamine-Mevidalen-Gs/β1/γ2
21.05Single7CMVPD1289077CMV-D3-PD128907-Gi1/β1/γ2
21.05Single7F0TDopamine7F0T-D1-Dopamine-Gs/β1/γ2
21.05Single7F1ZDopamine7F1Z-D1-Dopamine-GDP-Gs/β1/γ2
21.05Single7F61PF-036547467F61-H3-PF-03654746-Cholesterol
21.05Single7T32ZM-2413857T32-A2A-ZM-241385
21.05Single7T94PubChem 576644067T94-M2-Acetylcholine-PubChem 57664406-chim(NtGi1-Go)/β1/γ2
21.05Single7UL3Famotidine7UL3-H2-Famotidine
21.05Single7VUGJNJ-635330547VUG-GPR139-JNJ-63533054-Gi1/β1/γ2
21.05Single7VV6C48/807VV6-MRGPRX2-C48/80
21.05Single7WC9PubChem 1624213647WC9-5-HT2A-PubChem 162421364
21.05Single7WVUfMLF7WVU-FPR1-ALX-fMLF-Gi1/β1/γ2
21.05Single7XXH2MeSADP7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/β1/γ2
21.05Single7ZI0SAG7ZI0-SMO-SAG-Cholesterol
21.05Single8GEDConstrained Epinephrine8GED-β2-Constrained Epinephrine-Gs/β1/γ2
21.05Single8GG5Constrained Epinephrine8GG5-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
21.05Single8GG7Constrained Epinephrine8GG7-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
21.05Single8GGLConstrained Epinephrine8GGL-β2-Constrained Epinephrine
21.05Single8GGMConstrained Epinephrine8GGM-β2-Constrained Epinephrine
21.05Single8GGPConstrained Epinephrine8GGP-β2-Constrained Epinephrine
21.05Single8GGQConstrained Epinephrine8GGQ-β2-Constrained Epinephrine
21.05Single8GGXConstrained Epinephrine8GGX-β2-Constrained Epinephrine
21.05Single8H4LDoconexent8H4L-FFA4-Doconexent-chim(NtGi1-Gs-CtGq)/β1/γ2
21.05Single8HQN9-S-HODE8HQN-GPR132-9-S-HODE-Gi1/β1/γ2
21.05Single8IY9Niacin8IY9-HCA2-Niacin-Go/β1/γ2
21.05Single8JEI3-nitro-4-(propylamino)benzoic acid8JEI-HCAR3-3-nitro-4-(propylamino)benzoic acid-Gi1/β1/γ2
21.05Single8JERAcipimox8JER-HCA2-Acipimox-Go/β1/γ2
21.05Single8JIMMMF8JIM-HCA2-MMF-Gi1/β1/γ2
21.05Single8JLQFenoldopam8JLQ-TA1-Fenoldopam-Gs/β1/γ2
21.05Single8K4NVF08K4N-GPR34-VF0-Gi1/β1/γ2
21.05Single8RWIStilSwitch28RWI-A2A-StilSwitch2-Na
21.05Single8UHBRO52563908UHB-TA1-RO5256390-Gs/β1/γ2
21.05Single8UNLConstrained Epinephrine8UNL-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
21.05Single8UNMConstrained Epinephrine8UNM-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
21.05Single8UNOConstrained Epinephrine8UNO-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
21.05Single8UNWConstrained Epinephrine8UNW-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
21.05Single8UO0Constrained Epinephrine8UO0-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
21.05Single8UO1Constrained Epinephrine8UO1-β2-Constrained Epinephrine-GTP; Mg-Gs/β1/γ2
21.05Single8W88SEP-3638568W88-TA1-SEP-363856-Gs/β1/γ2
21.05Single8Y45ADL58598Y45-δ-ADL5859-Gi2/β1/γ2
21.05Single8Y53MK50468Y53-BB3-MK5046-chim(NtGi1-Gs-CtGq)/β1/γ2
21.05Single8YH2Adenosine8YH2-A3A-Adenosine-Gi1/β1/γ2
21.05Single9JKQMETH9JKQ-TA1-METH-Gs/β1/γ2
21.05Consensus5ht_on_gpOrthosteric Ligand5ht1_on_gp 5ht2_on_gp 5ht4_on_gp 5ht5_on_gp 5ht6_on_gp 5ht7_on_gp
21.05Consensuscb1_offOrthosteric Ligand5U09-CB1-Taranabant 5TGZ-CB1-AM6538
21.05Consensuscxcr2_onOrthosteric Ligand6LFM-CXCR2-Interleukin-8-Gi1/β1/γ2
21.05Consensushca_onOrthosteric Ligandhca2_on
21.05Consensusp2y1_on_gpOrthosteric Ligand7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/β1/γ2
20.83Single3NY9ICI118-5513NY9-β2-ICI118-551
20.83Single5VBLApelin mimetic peptide agonist5VBL-Apelin-Apelin mimetic peptide agonist
20.83Single5ZTYAM102575ZTY-CB2-AM10257
20.83Single6C1QPMX536C1Q-C5a1-PMX53-NDT9513727
20.83Single6KNMJN241-96KNM-Apelin-JN241-9
20.83Single6W2YPubChem 237279706W2Y-GABAB1; GABAB1-PubChem 5311042-PubChem 23727970
20.83Single6XBJCholesterol6XBJ-SMO-Cholesterol-Gi1/β1/γ2
20.83Single7RMGSubstance-P7RMG-NK1-Substance-P-chim(Gs-CtGq)/β1/γ2
20.83Single7Y1FDynorphin7Y1F-κ-Dynorphin-Gi1/β1/γ2
20.83Single8JLRA776368JLR-TA1-A77636-chim(NtGi1-Gs)/β1/γ2
20.83Single8XX6CXCL88XX6-CXCR2-CXCL8-Go/β1/γ2
20.83Consensuscb2_offOrthosteric Ligand5ZTY-CB2-AM10257
20.83Consensuscxcr3_onOrthosteric Ligand8HNK-CXCR3-CXCL11-Gi1/β1/γ2 8HNL-CXCR3-PS372424-Gi1/β1/γ2
20.83Consensuscxcr4_offOrthosteric Ligand4RWS-CXCR4-vMIP-II 3OE0-CXCR4-CVX15 3OE6-CXCR4-IT1t
20.83Consensuscxcr_on_gpOrthosteric Ligandcxcr3_on_gp cxcr4_on_gp cxcr1_on_gp cxcr2_on_gp
20.83Consensusdop_onOrthosteric Ligand8F7S-δ-Deltorphin-Gi1/β1/γ2
20.83Consensuskiss1_onOrthosteric Ligand8ZJD-Kiss1-Kisspeptin-10-chim(NtGi1-Gq)/β1/γ1
20.83Consensuskisspeptin_onOrthosteric Ligandkiss1_on
20.83Consensusox2_onOrthosteric Ligand7L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/β1/γ2 7SQO-OX2-TAK-925-Gi1/β1/γ2 7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/β1/γ2
20.83Consensusox2_on_gpOrthosteric Ligand7L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/β1/γ2 7SQO-OX2-TAK-925-Gi1/β1/γ2 7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/β1/γ2
20.83Consensuss1p_onOrthosteric Ligands1p1_on s1p3_on s1p5_on
20.83Consensuss1p_on_gpOrthosteric Ligands1p1_on_gp s1p3_on_gp s1p5_on_gp
20.69Single5UIW5P7-CCL55UIW-CCR5-5P7-CCL5
20.69Single6P9YPACAP6P9Y-PAC1-PACAP-Gs/β1/γ2
20.69Single7CZ5Somatoliberin7CZ5-GHRH-Somatoliberin-Gs/β1/γ2
20.69Single7RA3GIP7RA3-GIP-GIP-chim(NtGi1-Gs)/β1/γ2
20.69Single7RGPTirzepatide7RGP-GLP-1-Tirzepatide-chim(NtGi1-Gs)/β1/γ2
20.69Single7SK4CXCL12_LRHQ7SK4-ACKR3-CXCL12_LRHQ
20.69Single8JISPeptide-158JIS-GLP-1-Peptide-15-chim(NtGi1-Gs)/β1/γ2
20.69Single8XVEBQ30208XVE-ETB-BQ3020-chim(Gs-CtGq)/β1/γ2
20.69Single9J1Pg1:Ox9J1P-GLP-1-g1:Ox-chim(NtGi1-Gs)/β1/γ2
20.69Consensusccr5_offOrthosteric Ligand5UIW-CCR5-5P7-CCL5
20.69Consensusccr_offOrthosteric Ligandccr2_off ccr5_off
20.69Consensusnpy4_onOrthosteric Ligand7X9C-Y4-Pancreatic Hormone-Gi1/β1/γ2
20.69Consensusnpy4_on_gpOrthosteric Ligand7X9C-Y4-Pancreatic Hormone-Gi1/β1/γ2
20.59Single9JR3PTH9JR3-PTH1-PTH-chim(NtGi1L-Gs-CtGq)/β1/γ2
20.00Single2Y02Carmoterol2Y02-β1-Carmoterol
20.00Single3NY8ICI118-5513NY8-β2-ICI118-551
20.00Single3NYAS-Alprenolol3NYA-β2-S-Alprenolol
20.00Single3ZPQ4-(piperazin-1- yl)-1H-indole3ZPQ-β1-4-(piperazin-1- yl)-1H-indole-Na
20.00Single4AMJS-Carvedilol4AMJ-β1-S-Carvedilol
20.00Single4EJ4Naltrindole4EJ4-δ-Naltrindole
20.00Single4GBRS-Carazolol4GBR-β2-S-Carazolol
20.00Single5OLZPubChem 1355666095OLZ-A2A-PubChem 135566609-Na
20.00Single5OM1PubChem 1355666095OM1-A2A-PubChem 135566609-Na
20.00Single5TGZAM65385TGZ-CB1-AM6538
20.00Single5UENDU1725UEN-A1-DU172
20.00Single6D27CAY104716D27-DP2-CAY10471
20.00Single6DRZMethysergide6DRZ-5-HT2B-Methysergide
20.00Single6FKCPubChem 1324730396FKC-Rhodopsin-PubChem 132473039
20.00Single6PS1Timolol6PS1-β2-Timolol
20.00Single6PS2S-Alprenolol6PS2-β2-S-Alprenolol
20.00Single6TOTLemborexant6TOT-OX1-Lemborexant
20.00Single7BTSL-Epinephrine7BTS-β1-L-Epinephrine
20.00Single7BU6L-Norepinephrine7BU6-β1-L-Norepinephrine
20.00Single7CFMP3957CFM-GPBA-P395-Gs/β1/γ2
20.00Single7CRHSKF839597CRH-D1-SKF83959-Gs/β1/γ2
20.00Single7DTYGIP7DTY-GIP-GIP-Gs/β1/γ2
20.00Single7E32Serotonin7E32-5-HT1D-Serotonin-Gi1/β1/γ2
20.00Single7F54Afamelanotide7F54-MC4-Afamelanotide-Gs/β1/γ2
20.00Single7FIYTirzepatide7FIY-GIP-Tirzepatide-Gs/β1/γ2
20.00Single7JVQApomorphine7JVQ-D1-Apomorphine-Gs/β1/γ2
20.00Single7LJCSKF-812977LJC-D1-SKF-81297-Mevidalen-Gs/β1/γ2
20.00Single7NA7Ghrelin-277NA7-Ghrelin-Ghrelin-27-Gi1/β1/γ2
20.00Single7S0GIsoprenaline7S0G-β1-Isoprenaline-chim(Gi1-CtGs)/β1/γ2
20.00Single7S1MEx4-D-Ala7S1M-GLP-1-Ex4-D-Ala-Gs/β1/γ2
20.00Single7T6UCGEN-855A7T6U-FPR2-ALX-CGEN-855A-Gi1/β1/γ2
20.00Single7UL4Alvimopan7UL4-μ-Alvimopan
20.00Single7UM55-CT7UM5-5-HT5A-5-CT-chim(NtGi1-Go)/β1/γ2
20.00Single7UM6Lisuride7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/β1/γ2
20.00Single7VIES1P7VIE-S1P1-S1P-Gi1/β1/γ2
20.00Single7VQXPACAP277VQX-VPAC1-PACAP27-Gs/β1/γ2
20.00Single7W2ZGhrelin7W2Z-Ghrelin-Ghrelin-Go/β1/γ2
20.00Single7W53Neuromedin-U-257W53-NMUR1-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
20.00Single7WQ3Galanin7WQ3-GAL1-Galanin-Gi1/β1/γ2
20.00Single7X2CFenoldopam7X2C-D1-Fenoldopam-Fenoldopam-Gs/β1/γ2
20.00Single7XTC5-CT7XTC-5-HT7-5-CT-Gs/β1/γ2
20.00Single7YACPaltusotine7YAC-SST2-Paltusotine-Gi1/β1/γ2
20.00Single8CU6LJ-45178CU6-A2A-LJ-4517
20.00Single8CU7LJ-45178CU7-A2A-LJ-4517-Na
20.00Single8EFQDamgo8EFQ-μ-Damgo-Gi1/β1/γ2
20.00Single8G59TUG-8918G59-FFA4-TUG-891-chim(Gi1-CtGq)/β1/γ2
20.00Single8GE3Constrained Epinephrine8GE3-β2-Constrained Epinephrine-Gs/β1/γ2
20.00Single8GECConstrained Epinephrine8GEC-β2-Constrained Epinephrine-Gs/β1/γ2
20.00Single8GEEConstrained Epinephrine8GEE-β2-Constrained Epinephrine-Gs/β1/γ2
20.00Single8GEHConstrained Epinephrine8GEH-β2-Constrained Epinephrine-Gs/β1/γ2
20.00Single8GFVConstrained Epinephrine8GFV-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
20.00Single8GFWConstrained Epinephrine8GFW-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
20.00Single8GFXConstrained Epinephrine8GFX-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
20.00Single8GFZConstrained Epinephrine8GFZ-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
20.00Single8GG0Constrained Epinephrine8GG0-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
20.00Single8GG1Constrained Epinephrine8GG1-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
20.00Single8GG3Constrained Epinephrine8GG3-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
20.00Single8GG4Constrained Epinephrine8GG4-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
20.00Single8GG6Constrained Epinephrine8GG6-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
20.00Single8GG9Constrained Epinephrine8GG9-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
20.00Single8GGIConstrained Epinephrine8GGI-β2-Constrained Epinephrine
20.00Single8GGJConstrained Epinephrine8GGJ-β2-Constrained Epinephrine
20.00Single8GGKConstrained Epinephrine8GGK-β2-Constrained Epinephrine
20.00Single8GGNConstrained Epinephrine8GGN-β2-Constrained Epinephrine
20.00Single8GGOConstrained Epinephrine8GGO-β2-Constrained Epinephrine
20.00Single8GGUConstrained Epinephrine8GGU-β2-Constrained Epinephrine
20.00Single8HAOPTH8HAO-PTH1-PTH-chim(NtGi1-Gs)/β1/γ2
20.00Single8IC0Interleukin-88IC0-CXCR1-Interleukin-8-Gi1/β1/γ2
20.00Single8IEBA1LYA8IEB-GPR156-A1LYA
20.00Single8J6PNiacin8J6P-HCA2-Niacin-Compound 9n-Gi1/β1/γ2
20.00Single8JHNMMF8JHN-HCA2-MMF-Go/β1/γ2
20.00Single8JIINiacin8JII-HCA2-Niacin-Compound 9n-Gi1/β1/γ2
20.00Single8JJOAlprenolol8JJO-β2-Alprenolol
20.00Single8JLZST19368JLZ-5-HT6-ST1936-Gs/β1/γ2
20.00Single8JT8(R)-IHCH-71798JT8-5-HT2A-(R)-IHCH-7179
20.00Single8RWXStilSwitch38RWX-A2A-StilSwitch3-Na
20.00Single8UGYMianserin8UGY-5-HT1E-Mianserin-Gi1/β1/γ1
20.00Single8UH3Setiptiline8UH3-5-HT1E-Setiptiline-Gi1/β1/γ1
20.00Single8UNQConstrained Epinephrine8UNQ-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
20.00Single8UNRConstrained Epinephrine8UNR-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
20.00Single8UNUConstrained Epinephrine8UNU-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
20.00Single8UNVConstrained Epinephrine8UNV-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
20.00Single8UNYConstrained Epinephrine8UNY-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
20.00Single8UNZConstrained Epinephrine8UNZ-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
20.00Single8UO2Constrained Epinephrine8UO2-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
20.00Single8W8ARO52563908W8A-TA1-RO5256390-chim(NtGi1L-Gs)/β1/γ2
20.00Single8X9S5alpha-DHT8X9S-ADGRD1-5α-DHT-chim(NtGi1-Gs)/β1/γ2
20.00Single8XWNCXCL88XWN-CXCR2-CXCL8
20.00Single8XWPEndothelin-18XWP-ETB-Endothelin-1-Gi1/β1/γ2
20.00Single8YH5Riboprine8YH5-A3A-Riboprine-Gi1/β1/γ2
20.00Single8ZJDKisspeptin-108ZJD-Kiss1-Kisspeptin-10-chim(NtGi1-Gq)/β1/γ1
20.00Single8ZSPLSD8ZSP-TA1-LSD-chim(NtGi1L-Gs-CtGq)/β1/γ2
20.00Single8ZSSRO52633978ZSS-TA1-RO5263397-chim(NtGi1-Gs)/β1/γ2
20.00Single9BKJCholecystokinin-89BKJ-CCKA-Cholecystokinin-8-chim(NtGi1-Gs-CtGq)/β1/γ2
20.00Single9IV25alpha-DHT9IV2-ADGRD1-5α-DHT-chim(NtGi1-Gs)/β1/γ2
20.00Consensus5ht1d_onOrthosteric Ligand7E32-5-HT1D-Serotonin-Gi1/β1/γ2
20.00Consensus5ht1d_on_gpOrthosteric Ligand7E32-5-HT1D-Serotonin-Gi1/β1/γ2
20.00Consensus5ht2b_offOrthosteric Ligand6DRZ-5-HT2B-Methysergide
20.00Consensus5ht5_onOrthosteric Ligand5ht5a_on
20.00Consensus5ht5a_onOrthosteric Ligand7X5H-5-HT5A-5-CT-Gi1/β1/γ2 7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/β1/γ2 7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/β1/γ2
20.00Consensus5ht6_onOrthosteric Ligand7XTB-5-HT6-Serotonin-Gs/β1/γ2 8JLZ-5-HT6-ST1936-Gs/β1/γ2
20.00Consensus5ht6_on_gpOrthosteric Ligand7XTB-5-HT6-Serotonin-Gs/β1/γ2 8JLZ-5-HT6-ST1936-Gs/β1/γ2
20.00Consensus5ht7_onOrthosteric Ligand7XTC-5-HT7-5-CT-Gs/β1/γ2
20.00Consensus5ht7_on_gpOrthosteric Ligand7XTC-5-HT7-5-CT-Gs/β1/γ2
20.00Consensusadrenergic_onOrthosteric Ligandalpha_on beta_on
20.00Consensuscck_offOrthosteric Ligandccka_off
20.00Consensusccka_offOrthosteric Ligand7F8Y-CCKA-Devazepide 7F8U-CCKA-Lintitript
20.00Consensuscxcr1_on_gpOrthosteric Ligand8IC0-CXCR1-Interleukin-8-Gi1/β1/γ2
20.00Consensusdop_offOrthosteric Ligand4EJ4-δ-Naltrindole
20.00Consensusdopamine_offOrthosteric Ligandd2_off d3_off
20.00Consensusdopamine_onOrthosteric Ligandd2_on d1_on d3_on d4_on d5_on
20.00Consensusdopamine_on_gpOrthosteric Ligandd2_on_gp d1_on_gp d3_on_gp d4_on_gp d5_on_gp
20.00Consensusgal1_onOrthosteric Ligand7WQ3-GAL1-Galanin-Gi1/β1/γ2
20.00Consensusgal1_on_gpOrthosteric Ligand7WQ3-GAL1-Galanin-Gi1/β1/γ2
20.00Consensusgi_galaninOrthosteric Ligand7WQ3-GAL1-Galanin-Gi1/β1/γ2
20.00Consensusgi_hcaOrthosteric Ligand8J6R-HCA2-MK6892-Gi1/β1/γ2 8JIM-HCA2-MMF-Gi1/β1/γ2 8IHI-HCA2-Acifran-Gi1/β1/γ2 8IHH-HCA2-LUF6283-Gi1/β1/γ2 8I7V-HCA2-Acipimox-Gi1/β1/γ2 8I7W-HCA2-GSK256073-Gi1/β1/γ2
20.00Consensusgi_opioidOrthosteric Ligand8F7R-μ-Endomorphin-Gi1/β1/γ2 8EF5-μ-Fentanyl-Gi1/β1/γ2 7SCG-μ-FH210-Gi1/β1/γ2 7T2H-μ-Lofentanil-Gi1/β1/γ2 7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2 8DZP-κ-momSalB-Gi1/β1/γ2 8EF6-μ-Morphine-Gi1/β1/γ2 8F7X-NOP-Nociceptin-Gi1/β1/γ2 8EFB-μ-Oliceridine-Gi1/β1/γ2 7U2L-μ-PubChem 163201242-Gi1/β1/γ2 8EFO-μ-PZM21-Gi1/β1/γ2 8EFL-μ-SR17018-Gi1/β1/γ2 8F7Q-μ-β-Endorphin-Gi1/β1/γ2 7U2K-μ-C6-guano-Gi1/β1/γ2 8EFQ-μ-Damgo-Gi1/β1/γ2 8F7S-δ-Deltorphin-Gi1/β1/γ2 8F7W-κ-Dynorphin-Gi1/β1/γ2
20.00Consensusgq_kisspeptinOrthosteric Ligand8ZJD-Kiss1-Kisspeptin-10-chim(NtGi1-Gq)/β1/γ1
20.00Consensushca2_onOrthosteric Ligand8J6R-HCA2-MK6892-Gi1/β1/γ2 8JIM-HCA2-MMF-Gi1/β1/γ2 8I7V-HCA2-Acipimox-Gi1/β1/γ2 8I7W-HCA2-GSK256073-Gi1/β1/γ2 8IHH-HCA2-LUF6283-Gi1/β1/γ2 8IHI-HCA2-Acifran-Gi1/β1/γ2
20.00Consensushca2_on_gpOrthosteric Ligand8J6R-HCA2-MK6892-Gi1/β1/γ2 8IHI-HCA2-Acifran-Gi1/β1/γ2 8IHH-HCA2-LUF6283-Gi1/β1/γ2 8I7V-HCA2-Acipimox-Gi1/β1/γ2 8JIM-HCA2-MMF-Gi1/β1/γ2 8I7W-HCA2-GSK256073-Gi1/β1/γ2
20.00Consensushca_on_gpOrthosteric Ligandhca2_on_gp
20.00Consensuskiss1_on_gpOrthosteric Ligand8ZJD-Kiss1-Kisspeptin-10-chim(NtGi1-Gq)/β1/γ1
20.00Consensuskisspeptin_on_gpOrthosteric Ligandkiss1_on_gp
20.00Consensuslipid_offOrthosteric Ligandcannabinoid_off paf_off lpl_off prostanoid_off leukotriene_off
20.00Consensuslpl_onOrthosteric Ligands1p_on lpa_on
20.00Consensuslpl_on_gpOrthosteric Ligands1p_on_gp lpa_on_gp
20.00Consensusnmur1_on_gpOrthosteric Ligand7W53-NMUR1-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
20.00Consensussomatostatin_offOrthosteric Ligandsst2_off
19.35Single6WZGSecretin6WZG-Secretin-Secretin-Gs/β1/γ2
19.35Single7D68GLP-27D68-GLP-2-GLP-2-Gs/β1/γ2
19.35Single7KI1Taspoglutide7KI1-GLP-1-Taspoglutide-Gs/β1/γ2
19.35Single7VVLPTH7VVL-PTH1-PTH-Gs/β1/γ2
19.35Single8HAFPTHrP(1-36)8HAF-PTH1-PTHrP(1-36)-chim(NtGi1-Gs)/β1/γ2
19.35Consensusetb_onOrthosteric Ligand8IY5-ETB-Endothelin-1-Gi1/β1/γ2 8HBD-ETB-IRL1620-Gi1/β1/γ2
19.35Consensusgs_melanocortinOrthosteric Ligand7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2 7F54-MC4-Afamelanotide-Gs/β1/γ2 7F4D-MC1-α-MSH-chim(NtGi1-Gs)/β1/γ2 8INR-MC5-α-MSH-Ca-chim(NtGi1-Gs)/β1/γ2 7F53-MC4-α-MSH-Gs/β1/γ2 7F55-MC4-Bremelanotide-Gs/β1/γ2 8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1 8IOC-MC3-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2 8IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/β1/γ2 7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2 7F4I-MC1-SHU9119-chim(NtGi1-Gs)/β1/γ2 7F58-MC4-THIQ-Gs/β1/γ2
19.23Single5XJM(Sar1,Ile8)-Angiotensin II5XJM-AT2-(Sar1,Ile8)-Angiotensin II
19.23Single7C6A(Sar1,Ile8)-Angiotensin II7C6A-AT2-(Sar1,Ile8)-Angiotensin II
19.23Single7CUMPhospholipid7CUM-GABAB1, GABAB2-CGP54626-Phospholipid
19.23Single7SK5CXCL127SK5-ACKR3-CXCL12
19.23Single7TRYUrocortin7TRY-CRF2-Urocortin-chim(NtGi1-G11)/β1/γ2
19.23Single8F7QBeta-Endorphin8F7Q-μ-β-Endorphin-Gi1/β1/γ2
19.23Single8F7SDeltorphin8F7S-δ-Deltorphin-Gi1/β1/γ2
19.23Single8IEBA1LYA8IEB-GPR156-A1LYA
19.23Single8Z7JAgonistic antibody8Z7J-Apelin-Agonistic antibody-Gi1/β1/γ2
19.23Single9EAINanobody AT2099EAI-AT1-Losartan-Nanobody AT209
19.23Consensusccr8_on_gpOrthosteric Ligand8KFX-CCR8-LMD-009-Gi1/β1/γ2 8KFY-CCR8-ZK-756326-Gi1/β1/γ2 8U1U-CCR8-CCL1-Gi1/β1/γ2
19.23Consensusdop_on_gpOrthosteric Ligand8F7S-δ-Deltorphin-Gi1/β1/γ2
19.23Consensusgi_ghrelinOrthosteric Ligand7NA7-Ghrelin-Ghrelin-27-Gi1/β1/γ2 7NA8-Ghrelin-PubChem 178024-Gi1/β1/γ2
19.23Consensuss1p3_on_gpOrthosteric Ligand7EW3-S1P3-S1P-Gi1/β1/γ2 7EW4-S1P3-CYM5541-Gi1/β1/γ2 7EW2-S1P3-Fingolimod-Gi1/β1/γ2
19.05Single2RH1S-Carazolol2RH1-β2-S-Carazolol
19.05Single2YCWS-Carazolol2YCW-β1-S-Carazolol
19.05Single4JKVTaladegib4JKV-SMO-Taladegib
19.05Single4ZJ8Suvorexant4ZJ8-OX1-Suvorexant
19.05Single5C1MBU725C1M-μ-BU72
19.05Single5D6LS-Carazolol5D6L-β2-S-Carazolol
19.05Single5JQHS-Carazolol5JQH-β2-S-Carazolol
19.05Single5OM4PubChem 1355666095OM4-A2A-PubChem 135566609-Na
19.05Single5TVNLSD5TVN-5-HT2B-LSD
19.05Single5X7DS-Carazolol5X7D-β2-S-Carazolol-PubChem 129318963
19.05Single5ZBQUR-MK-2995ZBQ-Y1-UR-MK-299
19.05Single5ZK33-quinuclidinyl-benzilate5ZK3-M2-3-quinuclidinyl-benzilate
19.05Single6D26Fevipiprant6D26-DP2-Fevipiprant
19.05Single6E67BI1671076E67-β2-BI167107-Gs (fused)
19.05Single6KUWPubChem 572132346KUW-α2c-PubChem 57213234
19.05Single6ME82-Phenylmelatonin6ME8-MT2-2-Phenylmelatonin
19.05Single6PS3S-Carvedilol6PS3-β2-S-Carvedilol
19.05Single6PS6Timolol6PS6-β2-Timolol
19.05Single6TO7Suvorexant6TO7-OX1-Suvorexant-Na
19.05Single6TP6Filorexant6TP6-OX1-Filorexant
19.05Single6W2XPubChem 237279706W2X-GABAB1, GABAB2-PubChem 5311042-PubChem 23727970
19.05Single7BB7AVP7BB7-V2-AVP-Gs/β1/γ2
19.05Single7BVQS-Carazolol7BVQ-β1-S-Carazolol
19.05Single7EO2FTY720-P7EO2-S1P1-FTY720-P-Gi1/β1/γ2
19.05Single7EPFNAM5977EPF-mGlu2; mGlu2-NAM597
19.05Single7S0FIsoprenaline7S0F-β1-Isoprenaline-Gi1/β1/γ2
19.05Single7VV0PAMP-127VV0-MRGPRX2-PAMP-12
19.05Single7W41PD1762527W41-BB2-PD176252
19.05Single7XK9Constrained Isoproterenol7XK9-β2-Constrained Isoproterenol-Na
19.05Single7XKAConstrained Epinephrine7XKA-β2-Constrained Epinephrine
19.05Single8C9WEtrumadenant8C9W-A2A-Etrumadenant
19.05Single8GDZConstrained Epinephrine8GDZ-β2-Constrained Epinephrine-Gs/β1/γ2
19.05Single8GEBConstrained Epinephrine8GEB-β2-Constrained Epinephrine-Gs/β1/γ2
19.05Single8GEGConstrained Epinephrine8GEG-β2-Constrained Epinephrine-Gs/β1/γ2
19.05Single8GFYConstrained Epinephrine8GFY-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
19.05Single8GG2Constrained Epinephrine8GG2-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
19.05Single8GGBConstrained Epinephrine8GGB-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
19.05Single8IZ4Lysophosphatidylserine8IZ4-GPR34-Lysophosphatidylserine-Gi1/β1/γ2
19.05Single8J18(3R)-3-Hydroxydodecanoic acid8J18-GPR84-(3R)-3-Hydroxydodecanoic acid-Gi1/β1/γ2
19.05Single8S4DCMF-0198S4D-Apelin-CMF-019
19.05Single8TF5Oleic acid8TF5-GPR6-Oleic acid
19.05Single8UNNConstrained Epinephrine8UNN-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
19.05Single8UNPConstrained Epinephrine8UNP-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
19.05Single8UUJFCH-22964138UUJ-HCA2-FCH-2296413-Gi1/β1/γ2
19.05Single8X0DVU04244658X0D-mGlu5; mGlu5-Quisqualate-VU0424465
19.05Single8X0DVU04244658X0D-mGlu5; mGlu5-Quisqualate-VU0424465
19.05Single8YH0NECA8YH0-A3A-NECA-Gi1/β1/γ2
19.05Single9EAHNanobody AT2099EAH-AT1-Olmesartan-Nanobody AT209
19.05Single9IYBProstaglandin9IYB-DP2-Prostaglandin-A1D5Q-Gi1/β1/γ2
19.05Consensus5ht1_onOrthosteric Ligand5ht1a_on 5ht1d_on 5ht1e_on 5ht1f_on
19.05Consensus5ht1_on_gpOrthosteric Ligand5ht1a_on_gp 5ht1d_on_gp 5ht1e_on_gp 5ht1f_on_gp
19.05Consensus5ht1e_on_gpOrthosteric Ligand7E33-5-HT1E-BRL-54443-Gi1/β1/γ2 8UGY-5-HT1E-Mianserin-Gi1/β1/γ1 8UH3-5-HT1E-Setiptiline-Gi1/β1/γ1
19.05Consensus5ht5_on_gpOrthosteric Ligand5ht5a_on_gp
19.05Consensus5ht5a_on_gpOrthosteric Ligand7X5H-5-HT5A-5-CT-Gi1/β1/γ2 7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/β1/γ2 7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/β1/γ2
19.05Consensusadrenergic_offOrthosteric Ligandalpha_off beta_off
19.05Consensusadrenergic_on_gpOrthosteric Ligandalpha_on_gp beta_on_gp
19.05Consensusalpha2c_offOrthosteric Ligand6KUW-α2c-PubChem 57213234
19.05Consensusalpha_offOrthosteric Ligandalpha1_off alpha2_off
19.05Consensusamine_offOrthosteric Ligand5ht_off adrenergic_off dopamine_off histamine_off muscarinic_off
19.05Consensusamine_offonOrthosteric Ligandamine_off amine_on
19.05Consensusamine_offon_gpOrthosteric Ligandamine_on_gp amine_off
19.05Consensusamine_onOrthosteric Ligand5ht_on adrenergic_on dopamine_on histamine_on muscarinic_on trace-amine_on
19.05Consensusbb2_offOrthosteric Ligand7W41-BB2-PD176252
19.05Consensusbeta2_offOrthosteric Ligand2RH1-β2-S-Carazolol 6PS3-β2-S-Carvedilol 6PS5-β2-S-Propranolol 3D4S-β2-Timolol 3NY8-β2-ICI118-551 3NY9-β2-ICI118-551 6PRZ-β2-S-Alprenolol
19.05Consensusbeta_offOrthosteric Ligandbeta1_off beta2_off
19.05Consensusbombesin_offOrthosteric Ligandbb2_off
19.05Consensusd2_onOrthosteric Ligand7JVR-D2-Bromoergocryptine-Gi1/β1/γ2 8IRS-D2-Rotigotine-Gi1/β1/γ2
19.05Consensusdp2_offOrthosteric Ligand6D26-DP2-Fevipiprant
19.05Consensusdp_offOrthosteric Liganddp2_off
19.05Consensusgi_adrenergicOrthosteric Ligand7EJ0-α2a-L-Norepinephrine-Go/β1/γ2 7EJK-α2a-Oxymetazoline-Go/β1/γ2 7W7E-α2a-PubChem 164946676-Go/β1/γ2 7W6P-α2a-N-pyridin-4-ylisoquinolin-4-amine-Go/β1/γ2 7EJ8-α2a-Brimonidine-Go/β1/γ2 6K42-α2b-Dexmedetomidine-Gi1/β1/γ2 7EJA-α2a-Dexmedetomidine-Go/β1/γ2 7S0F-β1-Isoprenaline-Gi1/β1/γ2
19.05Consensusta1_onOrthosteric Ligand8W87-TA1-METH-chim(NtGi1L-Gs)/β1/γ2 8W89-TA1-PEA-chim(NtGi1L-Gs)/β1/γ2 8JLP-TA1-Ralmitaront-Gs/β1/γ2 8W8A-TA1-RO5256390-chim(NtGi1L-Gs)/β1/γ2 8W88-TA1-SEP-363856-Gs/β1/γ2 8JLO-TA1-Ulotaront-Gs/β1/γ2 8JLR-TA1-A77636-chim(NtGi1-Gs)/β1/γ2 8JSO-TA1-AMPH-chim(NtGi1-Gs)/β1/γ2 8ZSP-TA1-LSD-chim(NtGi1L-Gs-CtGq)/β1/γ2
19.05Consensustrace-amine_onOrthosteric Ligandta1_on
18.75Single3RFMCaffeine3RFM-A2A-Caffeine
18.75Single6OT025(S)-Epoxycholesterol6OT0-SMO-25(S)-Epoxycholesterol-Gi1/β1/γ2
18.75Single7RBTTirzepatide7RBT-GIP-Tirzepatide-PubChem 163183774-chim(NtGi1-Gs)/β1/γ2
18.75Single8GEIConstrained Epinephrine8GEI-β2-Constrained Epinephrine-Gs/β1/γ2
18.75Single8U4QREGN7663-Fab8U4Q-CXCR4-REGN7663-Fab-Cholesterol-Gi1/β1/γ2
18.75Consensusgi_endothelinOrthosteric Ligand8IY5-ETB-Endothelin-1-Gi1/β1/γ2 8HBD-ETB-IRL1620-Gi1/β1/γ2
18.75Consensusp2y_offOrthosteric Ligandp2y1_off
18.52Single3OE0CVX153OE0-CXCR4-CVX15
18.52Single6PT2KGCHM076PT2-δ-KGCHM07
18.52Single6VN7PACAP6VN7-VPAC1-PACAP-Gs/β1/γ2
18.52Single7F4DAlpha-MSH7F4D-MC1-α-MSH-chim(NtGi1-Gs)/β1/γ2
18.52Single7TD0LPA7TD0-LPA1-LPA-Gi1/β1/γ2
18.52Single7W55Neuromedin-U-257W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
18.52Single7XA3CCL27XA3-CCR2-CCL2-Gi1/β1/γ2
18.52Single8K6MNeuropeptide-Y8K6M-Y1-Neuropeptide-Y-Gi2/β1/γ1
18.52Single8XGUTAK4488XGU-Kiss1-TAK448-Gi1/β1/γ2
18.52Single8XIQL7967788XIQ-SST3-L796778-chim(NtGi1-Gs-CtGi1)/β1/γ2
18.52Single8XZHMM078XZH-Apelin-MM07-Gi1/β1/γ2
18.52Single9B54A1AIW9B54-CB1-A1AIW-Gi1/β1/γ2
18.52Single9IVMGLP-1 (Truncated)9IVM-GLP-1-GLP-1 (Truncated)-LSN3318839-chim(NtGi1-Gs)/β2/γ2
18.52Consensusc5a1_onOrthosteric Ligand8HK5-C5a1-Complement C5-Gi1/β1/γ2 7Y66-C5a1-BM213-Gi1/β1/γ2 7Y67-C5a1-C089 peptide-Gi1/β1/γ2 7Y64-C5a1-C5a anaphylatoxin-Gi1/β1/γ2
18.52Consensusccr2_onOrthosteric Ligand7XA3-CCR2-CCL2-Gi1/β1/γ2
18.52Consensusccr2_on_gpOrthosteric Ligand7XA3-CCR2-CCL2-Gi1/β1/γ2
18.52Consensusccr_onOrthosteric Ligandccr6_on ccr8_on ccr2_on ccr1_on ccr5_on
18.52Consensusfpr2-alx_onOrthosteric Ligand7WVX-FPR2-ALX-Humanin-Gi2/β1/γ2 7T6U-FPR2-ALX-CGEN-855A-Gi1/β1/γ2 7T6V-FPR2-ALX-fMLFII-Gi1/β1/γ2 7WVY-FPR2-ALX-Amyloid-β42-Gi2/β1/γ2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/β1/γ2 6OMM-FPR2-ALX-WKYMVX-Gi1/β1/γ2
18.52Consensusnmur2_onOrthosteric Ligand7W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
18.52Consensusnmur2_on_gpOrthosteric Ligand7W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
18.52Consensusnpy1_onOrthosteric Ligand8K6M-Y1-Neuropeptide-Y-Gi2/β1/γ1
18.52Consensusnpy1_on_gpOrthosteric Ligand8K6M-Y1-Neuropeptide-Y-Gi2/β1/γ1
18.18Single3P0GBI1671073P0G-β2-BI167107
18.18Single3SN6BI1671073SN6-β2-BI167107-Gs/β1/γ2
18.18Single3UON3-quinuclidinyl-benzilate3UON-M2-3-quinuclidinyl-benzilate
18.18Single4IAQDihydroergotamine4IAQ-5-HT1B-Dihydroergotamine
18.18Single4Z34ONO-97803074Z34-LPA1-ONO-9780307
18.18Single5D5AS-Carazolol5D5A-β2-S-Carazolol
18.18Single5D5BS-Carazolol5D5B-β2-S-Carazolol
18.18Single5V57TC1145V57-SMO-TC114
18.18Single5ZHPPubChem 1348285895ZHP-M3-PubChem 134828589
18.18Single6DDEDamgo6DDE-μ-Damgo-Gi1/β1/γ2
18.18Single6GT3Imaradenant6GT3-A2A-Imaradenant-Na
18.18Single6H7JIsoprenaline6H7J-β1-Isoprenaline
18.18Single6J20Aprepitant6J20-NK1-Aprepitant
18.18Single6KO5PubChem 574000026KO5-Ghrelin-PubChem 57400002
18.18Single6LPBPACAP6LPB-PAC1-PACAP-Gs/β1/γ1
18.18Single6N48BI1671076N48-β2-BI167107-PubChem 138454256
18.18Single6NI3BI1671076NI3-β2-BI167107-Gs/β1/γ2
18.18Single6OS1TRV0266OS1-AT1-TRV026
18.18Single6RZ5Zafirlukast6RZ5-CysLT1-Zafirlukast-Na
18.18Single7B6WCyclazosin7B6W-α1b-Cyclazosin
18.18Single7EW7SEW28717EW7-S1P1-SEW2871-Gi1/β1/γ2
18.18Single7F1TMIP-1a7F1T-CCR5-MIP-1a
18.18Single7F58THIQ7F58-MC4-THIQ-Gs/β1/γ2
18.18Single7JJOIsoprenaline7JJO-β1-Isoprenaline-Gs/β1/γ2
18.18Single7TUYGSK682753A7TUY-GPR183-GSK682753A
18.18Single7VIGCBP-3077VIG-S1P1-CBP-307-Gi1/β1/γ2
18.18Single7W6PN-pyridin-4-ylisoquinolin-4-amine7W6P-α2a-N-pyridin-4-ylisoquinolin-4-amine-Go/β1/γ2
18.18Single7W7EPubChem 1649466767W7E-α2a-PubChem 164946676-Go/β1/γ2
18.18Single7WV9CP559407WV9-CB1-CP55940-ZCZ011-Gi2/β1/γ2
18.18Single7WVXHumanin7WVX-FPR2-ALX-Humanin-Gi2/β1/γ2
18.18Single7XJLSpexin7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/β1/γ2
18.18Single7XTQR3997XTQ-GPBA-R399-Gs/β1/γ2
18.18Single7Y67C089 peptide7Y67-C5a1-C089 peptide-Gi1/β1/γ2
18.18Single8DCSCyanopindolol8DCS-β1-Cyanopindolol-Gs/β1/γ2
18.18Single8E0GBU728E0G-μ-BU72
18.18Single8FLULong-Acting PTH8FLU-PTH1-Long-Acting PTH-Gs/β1/γ2
18.18Single8HBDIRL16208HBD-ETB-IRL1620-Gi1/β1/γ2
18.18Single8I9LC3a anaphylatoxin8I9L-C3aB-C3a anaphylatoxin-Go/β1/γ2
18.18Single8IHBGSK2560738IHB-HCA2-GSK256073-Gi1/β1/γ2
18.18Single8IHHLUF62838IHH-HCA2-LUF6283-Gi1/β1/γ2
18.18Single8IRRRotigotine8IRR-D1-Rotigotine-Gs/β1/γ2
18.18Single8IRVRotigotine8IRV-D5-Rotigotine-chim(NtGi1-Gs)/β1/γ2
18.18Single8JXWVUF68848JXW-H4-VUF6884-Gi1/β1/γ2
18.18Single8T1VPubChem 1183102098T1V-GPR6-PubChem 118310209-Na
18.18Single8WJXADP8WJX-P2Y1-ADP-chim(Gs-CtGq)/β1/γ2
18.18Single9ASTLymphotactin9AST-XCR1-Lymphotactin-Gi1/β1/γ2
18.18Consensusamine_on_gpOrthosteric Ligand5ht_on_gp adrenergic_on_gp dopamine_on_gp histamine_on_gp muscarinic_on_gp trace-amine_on_gp
18.18Consensusbeta1_offOrthosteric Ligand2VT4-β1-Cyanopindolol 2YCW-β1-S-Carazolol 2YCZ-β1-Iodocyanopindolol 5A8E-β1-7-Methylcyanopindolol-Na 3ZPQ-β1-4-(piperazin-1- yl)-1H-indole-Na 3ZPR-β1-4-methyl-2-(piperazin-1-yl)-Na
18.18Consensusbeta2_onOrthosteric Ligand7DHI-β2-Salbutamol-Gs/β1/γ2 6NI3-β2-BI167107-Gs/β1/γ2
18.18Consensusbeta2_on_gpOrthosteric Ligand7DHI-β2-Salbutamol-Gs/β1/γ2 6NI3-β2-BI167107-Gs/β1/γ2
18.18Consensuscyslt1_offOrthosteric Ligand6RZ5-CysLT1-Zafirlukast-Na 6RZ4-CysLT1-Pranlukast-Na
18.18Consensusd5_on_gpOrthosteric Ligand8IRV-D5-Rotigotine-chim(NtGi1-Gs)/β1/γ2
18.18Consensusetb_on_gpOrthosteric Ligand8IY5-ETB-Endothelin-1-Gi1/β1/γ2 8HBD-ETB-IRL1620-Gi1/β1/γ2
18.18Consensusgi_5htOrthosteric Ligand8FYT-5-HT1A-LSD-Gi1/β1/γ1 7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/β1/γ2 8UGY-5-HT1E-Mianserin-Gi1/β1/γ1 8W8B-5-HT1A-SEP-363856-Gi1/β1/γ2 7E2Y-5-HT1A-Serotonin-Gi1/β1/γ2 7E32-5-HT1D-Serotonin-Gi1/β1/γ2 7XTA-5-HT4-Serotonin-Gi1/β1/γ2 8UH3-5-HT1E-Setiptiline-Gi1/β1/γ1 8JSP-5-HT1A-Ulotaront-Gi1/β1/γ2 8FYL-5-HT1A-Vilazodone-Gi1/β1/γ1 8JT6-5-HT1A-(R)-IHCH-7179-Gi1/β1/γ2 8FYE-5-HT1A-4-F,5-MeO-PyrT-Gi1/β1/γ1 7X5H-5-HT5A-5-CT-Gi1/β1/γ2 8FY8-5-HT1A-5-MeO-DMT-Gi1/β1/γ1 7E2Z-5-HT1A-Aripiprazole-Gi1/β1/γ2 7E33-5-HT1E-BRL-54443-Gi1/β1/γ2 8FYX-5-HT1A-Buspirone-Gi1/β1/γ1 7EXD-5-HT1F-Lasmiditan-Gi1/β1/γ2 7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/β1/γ2
18.18Consensusgi_relaxinOrthosteric Ligand7YK7-RXFP4-DC591053-Gi2/β1/γ2 7YJ4-RXFP4-INSL5-Gi2/β1/γ2 7YK6-RXFP4-PubChem 138319674-Gi2/β1/γ2
18.18Consensusmelanocortin_onOrthosteric Ligandmc1_on mc4_on mc2_on mc3_on mc5_on
18.18Consensusmelanocortin_on_gpOrthosteric Ligandmc1_on_gp mc4_on_gp mc2_on_gp mc3_on_gp mc5_on_gp
18.18Consensusrelaxin_onOrthosteric Ligandrxfp4_on
18.18Consensusrelaxin_on_gpOrthosteric Ligandrxfp4_on_gp
18.18Consensusta1_on_gpOrthosteric Ligand8W87-TA1-METH-chim(NtGi1L-Gs)/β1/γ2 8W89-TA1-PEA-chim(NtGi1L-Gs)/β1/γ2 8JLP-TA1-Ralmitaront-Gs/β1/γ2 8W8A-TA1-RO5256390-chim(NtGi1L-Gs)/β1/γ2 8W88-TA1-SEP-363856-Gs/β1/γ2 8JLO-TA1-Ulotaront-Gs/β1/γ2 8JLR-TA1-A77636-chim(NtGi1-Gs)/β1/γ2 8JSO-TA1-AMPH-chim(NtGi1-Gs)/β1/γ2 8ZSP-TA1-LSD-chim(NtGi1L-Gs-CtGq)/β1/γ2
18.18Consensustrace-amine_on_gpOrthosteric Ligandta1_on_gp
17.86Single6NIYAdrenomedullin6NIY-CT-Adrenomedullin-Gs/β1/γ2
17.86Single7F4HAfamelanotide7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2
17.86Single7FIMTirzepatide7FIM-GLP-1-Tirzepatide-Gs/β1/γ2
17.86Single7FINPeptide-20; GGL7FIN-GIP-Peptide-20; GGL-Gs/β1/γ2
17.86Single7T10Somatostatin-147T10-SST2-Somatostatin-14-Gi3/β1/γ2
17.86Single7WUIIP157WUI-ADGRG2-IP15-chim(NtGi1-Gs)/β1/γ2
17.86Single7XK8Neuromedin-U-257XK8-NMUR2-Neuromedin-U-25-Gi1/β1/γ2
17.86Single8HA0PTH8HA0-PTH1-PTH-chim(NtGi1-Gs)/β1/γ2
17.86Single8IEDA1LYA8IED-GPR156-A1LYA-Go/β1/γ2
17.86Single8XWQEndothelin-18XWQ-ETB-Endothelin-1-Gi1/β1/γ2
17.86Single8YW3Retatrutide8YW3-GLP-1-Retatrutide-Gs/β1/γ2
17.86Single8YW5Retatrutide8YW5-Glucagon-Retatrutide-Gs/β1/γ2
17.86Consensusapelin_onOrthosteric Ligand8XZH-Apelin-MM07-Gi1/β1/γ2 7W0M-Apelin-PubChem 122701908-Gi1/β1/γ2 8XZJ-Apelin-WN353-Gi1/β1/γ2 8XZF-Apelin-WN561-Gi1/β1/γ2 8XZG-Apelin-Apelin-13-Gi1/β1/γ2
17.86Consensusapelin_on_gpOrthosteric Ligand8XZH-Apelin-MM07-Gi1/β1/γ2 7W0M-Apelin-PubChem 122701908-Gi1/β1/γ2 8XZJ-Apelin-WN353-Gi1/β1/γ2 8XZF-Apelin-WN561-Gi1/β1/γ2 8XZG-Apelin-Apelin-13-Gi1/β1/γ2
17.86Consensusc5a1_on_gpOrthosteric Ligand8HK5-C5a1-Complement C5-Gi1/β1/γ2 7Y66-C5a1-BM213-Gi1/β1/γ2 7Y67-C5a1-C089 peptide-Gi1/β1/γ2 7Y64-C5a1-C5a anaphylatoxin-Gi1/β1/γ2
17.86Consensusfpr2-alx_on_gpOrthosteric Ligand7WVX-FPR2-ALX-Humanin-Gi2/β1/γ2 7T6U-FPR2-ALX-CGEN-855A-Gi1/β1/γ2 7T6V-FPR2-ALX-fMLFII-Gi1/β1/γ2 7WVY-FPR2-ALX-Amyloid-β42-Gi2/β1/γ2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/β1/γ2 6OMM-FPR2-ALX-WKYMVX-Gi1/β1/γ2
17.86Consensusneuromedin-u_onOrthosteric Ligandnmur1_on nmur2_on
17.65Single3UZAGTPL92363UZA-A2A-GTPL9236
17.65Single6FK9PubChem 1324730366FK9-Rhodopsin-PubChem 132473036
17.65Single6WPWGlucagon derivative ZP37806WPW-Glucagon-Glucagon derivative ZP3780-Gs/β1/γ2
17.65Single7D77Hydrocortisone7D77-ADGRG3-Hydrocortisone-Go/β1/γ2
17.65Single7F23Dopamine7F23-D1-Dopamine-GDP-Gs/β1/γ2
17.65Single7MT9All-trans-Retinal7MT9-Rhodopsin-All-trans-Retinal-GRK1
17.65Single7MTAAll-trans-Retinal7MTA-Rhodopsin-All-trans-Retinal-GRK1
17.65Single7WC5Psilocin7WC5-5-HT2A-Psilocin
17.65Single8GH1Constrained Epinephrine8GH1-β2-Constrained Epinephrine
17.65Single8IW72-Phenylethylamine8IW7-TA9-2-Phenylethylamine-chim(NtGi1-Gs)/β1/γ2
17.65Single8J24Acetic acid8J24-FFA2-Acetic acid-Gi1/β1/γ2
17.65Single8J6QBeta-Hydroxybutyrate8J6Q-HCA2-β-Hydroxybutyrate-Compound 9n-Gi1/β1/γ2
17.65Single8JEF(3S)-3-hydroxyoctanoic acid8JEF-HCA3-(3S)-3-hydroxyoctanoic acid-Gi1/β1/γ2
17.65Single8JIRSAR4258998JIR-GLP-1-SAR425899-chim(NtGi1-Gs)/β1/γ2
17.65Single8JPSCCL78JPS-ACKR1-CCL7
17.65Single8WC62-Phenylethylamine8WC6-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/β1/γ2
17.65Single8YN9Histamine8YN9-H4-Histamine-Gi1/β1/γ2
17.65Single8YUUHistamine8YUU-H3-Histamine-Gi1/β1/γ1
17.65Single9JR2PTH9JR2-PTH1-PTH-chim(NtGi1L-Gs-CtGq)/β1/γ2
17.65Consensus5ht2_onOrthosteric Ligand5ht2b_on
17.65Consensus5ht2b_onOrthosteric Ligand7SRR-5-HT2B-LSD-chim(NtGi2L-Gs-CtGq)/β1/γ2
17.65Consensush3_onOrthosteric Ligand8YUU-H3-Histamine-Gi1/β1/γ1
17.65Consensush3_on_gpOrthosteric Ligand8YUU-H3-Histamine-Gi1/β1/γ1
17.39Single2YCXCyanopindolol2YCX-β1-Cyanopindolol
17.39Single3D4STimolol3D4S-β2-Timolol
17.39Single4LDEBI1671074LDE-β2-BI167107
17.39Single4OR2FITM4OR2-mGlu1; mGlu1-FITM
17.39Single5F8UCyanopindolol5F8U-β1-Cyanopindolol
17.39Single6C1RPMX536C1R-C5a1-PMX53-Avacopan; Na
17.39Single6DRYMethylergonovine6DRY-5-HT2B-Methylergonovine
17.39Single6H7OCyanopindolol6H7O-β1-Cyanopindolol
17.39Single7BZ2Arformoterol7BZ2-β2-Arformoterol-Gs/β1/γ2
17.39Single7EW2Fingolimod7EW2-S1P3-Fingolimod-Gi1/β1/γ2
17.39Single7K15MKD0467K15-BLT1-MKD046-Na
17.39Single7MTRADX551647MTR-mGlu2; mGlu2-Glutamate-ADX55164
17.39Single7SUSPubChem 1227019087SUS-Apelin-PubChem 122701908
17.39Single7W0LPubChem 1227019087W0L-Apelin-PubChem 122701908-Gi1/β1/γ2
17.39Single7WCNAR2314537WCN-GPR119-AR231453-Gs/β1/γ2
17.39Single7WQ4Galanin7WQ4-GAL2-Galanin-chim(NtGi1-Gs-CtGq)/β1/γ2
17.39Single7XZ5Lysophosphatidylcholine7XZ5-GPR119-Lysophosphatidylcholine-Gs/β1/γ2
17.39Single8E9W2-Deoxycytidine8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/β1/γ2
17.39Single8FYE4-F,5-MeO-PyrT8FYE-5-HT1A-4-F,5-MeO-PyrT-Gi1/β1/γ1
17.39Single8IRSRotigotine8IRS-D2-Rotigotine-Gi1/β1/γ2
17.39Single8IYWGSK2560738IYW-HCA2-GSK256073-Go/β1/γ2
17.39Single8JJ8Formoterol8JJ8-β2-Formoterol
17.39Single8JWZAB9288JWZ-A2A-AB928-Na
17.39Single8JZ7MK68928JZ7-HCA2-MK6892-Gi1/β1/γ2
17.39Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/β1/γ2
17.39Single8XX3CXCL38XX3-CXCR2-CXCL3-Go/β1/γ2
17.39Single9IZHLPA9IZH-LPA1-LPA-chim(NtGi2-G13)/β1/γ2
17.39Consensusbeta3_onOrthosteric Ligand7DH5-β3-Mirabegron-Gs/β1/γ2 7XJH-β3-Isoproterenol-Gs/β1/γ2 7XJI-β3-Solabegron-Gs/β1/γ2
17.39Consensusbeta3_on_gpOrthosteric Ligand7DH5-β3-Mirabegron-Gs/β1/γ2 7XJH-β3-Isoproterenol-Gs/β1/γ2 7XJI-β3-Solabegron-Gs/β1/γ2
17.39Consensusbeta_onOrthosteric Ligandbeta1_on beta2_on beta3_on
17.39Consensusbeta_on_gpOrthosteric Ligandbeta1_on_gp beta2_on_gp beta3_on_gp
17.39Consensusgi_amineOrthosteric Ligandgi_5ht gi_muscarinic gi_adrenergic gi_dopamine gi_histamine
17.39Consensusgi_muscarinicOrthosteric Ligand8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/β1/γ2 7T8X-M2-Acetylcholine-chim(NtGi1-Go)/β1/γ2 7TRS-M4-Acetylcholine-Gi1/β1/γ2 7TRK-M4-Iperoxo-Gi1/β1/γ2 7V6A-M4-PubChem 9864275-Gi1/β1/γ2
17.39Consensuslpa1_offOrthosteric Ligand4Z36-LPA1-ONO-3080573 4Z35-LPA1-ONO-9910539 4Z34-LPA1-ONO-9780307
17.39Consensuslpa_offOrthosteric Ligandlpa1_off
17.39Consensuslpl_offOrthosteric Ligands1p_off lpa_off
17.39Consensusmop_onOrthosteric Ligand8F7R-μ-Endomorphin-Gi1/β1/γ2 8EF5-μ-Fentanyl-Gi1/β1/γ2 7SCG-μ-FH210-Gi1/β1/γ2 7T2H-μ-Lofentanil-Gi1/β1/γ2 7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2 8EF6-μ-Morphine-Gi1/β1/γ2 8EFB-μ-Oliceridine-Gi1/β1/γ2 7U2L-μ-PubChem 163201242-Gi1/β1/γ2 8EFO-μ-PZM21-Gi1/β1/γ2 8EFL-μ-SR17018-Gi1/β1/γ2 8F7Q-μ-β-Endorphin-Gi1/β1/γ2 7U2K-μ-C6-guano-Gi1/β1/γ2 8EFQ-μ-Damgo-Gi1/β1/γ2
17.39Consensusmop_on_gpOrthosteric Ligand8F7R-μ-Endomorphin-Gi1/β1/γ2 8EF5-μ-Fentanyl-Gi1/β1/γ2 7SCG-μ-FH210-Gi1/β1/γ2 7T2H-μ-Lofentanil-Gi1/β1/γ2 7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2 8EF6-μ-Morphine-Gi1/β1/γ2 8EFB-μ-Oliceridine-Gi1/β1/γ2 7U2L-μ-PubChem 163201242-Gi1/β1/γ2 8EFO-μ-PZM21-Gi1/β1/γ2 8EFL-μ-SR17018-Gi1/β1/γ2 8F7Q-μ-β-Endorphin-Gi1/β1/γ2 7U2K-μ-C6-guano-Gi1/β1/γ2 8EFQ-μ-Damgo-Gi1/β1/γ2
17.39Consensusnk1_offOrthosteric Ligand6HLP-NK1-Netupitant 6HLO-NK1-Aprepitant 6HLL-NK1-CP99994 6E59-NK1-L-760735
17.39Consensusopioid_offOrthosteric Ligandmop_off nop_off dop_off kop_off
17.39Consensusorexin_onOrthosteric Ligandox2_on
17.24Single7F9YGhrelin-287F9Y-Ghrelin-Ghrelin-28-chim(NtGi1-Gs-CtGq)/β1/γ2
17.24Single7TYHCalcitonin-17TYH-CT (AMY2)-Calcitonin-1-Gs/β1/γ2; RAMP2
17.24Single7WBJPACAP277WBJ-VPAC1-PACAP27-Gs/β1/γ2
17.24Single8E3YPACAP278E3Y-VPAC1-PACAP27-Gs/β1/γ2
17.24Single8E3ZVIP8E3Z-VPAC1-VIP-Gs/β1/γ2
17.24Single8ZRTET-18ZRT-ETB-ET-1
17.24Consensusccr_on_gpOrthosteric Ligandccr6_on_gp ccr8_on_gp ccr2_on_gp ccr1_on_gp ccr5_on_gp
17.24Consensuscxcr_offOrthosteric Ligandcxcr3_off cxcr4_off
17.24Consensusmc1_onOrthosteric Ligand7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2 7F4D-MC1-α-MSH-chim(NtGi1-Gs)/β1/γ2 7F4I-MC1-SHU9119-chim(NtGi1-Gs)/β1/γ2
17.24Consensusmc1_on_gpOrthosteric Ligand7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2 7F4D-MC1-α-MSH-chim(NtGi1-Gs)/β1/γ2 7F4I-MC1-SHU9119-chim(NtGi1-Gs)/β1/γ2
17.24Consensusneuromedin-u_on_gpOrthosteric Ligandnmur1_on_gp nmur2_on_gp
17.14Single7TYOCalcitonin7TYO-CT-Calcitonin-Gs/β1/γ2
17.14Single8JITMEDI03828JIT-Glucagon-MEDI0382-Gs/β1/γ2
17.14Single8JIUSAR4258998JIU-Glucagon-SAR425899-Gs/β1/γ2
16.67Single3OE9IT1t3OE9-CXCR4-IT1t
16.67Single3PBLEticlopride3PBL-D3-Eticlopride
16.67Single4OR2FITM4OR2-mGlu1; mGlu1-FITM
16.67Single4RWSvMIP-II4RWS-CXCR4-vMIP-II
16.67Single4Z35ONO-99105394Z35-LPA1-ONO-9910539
16.67Single5L7IVismodegib5L7I-SMO-Vismodegib
16.67Single6DDFDamgo6DDF-μ-Damgo-Gi1/β1/γ2
16.67Single6E3YCalcitonin gene-related peptide-16E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/β1/γ2; RAMP1
16.67Single6FK6PubChem 1324730336FK6-Rhodopsin-PubChem 132473033
16.67Single6H7LDobutamine6H7L-β1-Dobutamine
16.67Single6HLLCP999946HLL-NK1-CP99994
16.67Single6PGSGeraniol6PGS-Rhodopsin-Geraniol-Gt(CT)
16.67Single6PH7Nerol6PH7-Rhodopsin-Nerol-Gt(CT)
16.67Single6QNOAll-trans-Retinal6QNO-Rhodopsin-All-trans-Retinal-Gi1/β1/γ1
16.67Single6TQ4PubChem 160468446TQ4-OX1-PubChem 16046844-Na
16.67Single7E2YSerotonin7E2Y-5-HT1A-Serotonin-Gi1/β1/γ2
16.67Single7JVRBromoergocryptine7JVR-D2-Bromoergocryptine-Gi1/β1/γ2
16.67Single7LLLExendin-47LLL-GLP-1-Exendin-4-Gs/β1/γ2
16.67Single7MTSADX551647MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/β1/γ2
16.67Single7SK3CXCL127SK3-ACKR3-CXCL12
16.67Single7SRQLSD7SRQ-5-HT2B-LSD
16.67Single7T96LY21196207T96-M2-Acetylcholine-LY2119620-Go/β1/γ2
16.67Single7TRPLY20332987TRP-M4-Iperoxo-LY2033298-Gi1/β1/γ2
16.67Single7UL2SR486927UL2-NTS1-SR48692-Na
16.67Single7UM4AS26747237UM4-5-HT5A-AS2674723
16.67Single7VGY2-Iodomelatonin7VGY-MT1-2-Iodomelatonin-Gi1/β1/γ2
16.67Single7VVNPTH7VVN-PTH1-PTH-Gs/β1/γ2
16.67Single7X1UTRH7X1U-TRH-TRH-chim(NtGi2L-Gs-CtGq)/β1/γ2
16.67Single7X2DTavapadon7X2D-D1-Tavapadon-Gs/β1/γ2
16.67Single7XJISolabegron7XJI-β3-Solabegron-Gs/β1/γ2
16.67Single7XTBSerotonin7XTB-5-HT6-Serotonin-Gs/β1/γ2
16.67Single7YFCHistamine7YFC-H4-Histamine-chim(NtGi1-Gs-CtGq)/β1/γ2
16.67Single7YU8ONO-07405567YU8-LPA1-ONO-0740556-Gi1/β1/γ2
16.67Single8E9YClozapine-N-oxide8E9Y-M3-Clozapine-N-oxide-chim(NtGi2L-Gs-CtGq)/β1/γ2
16.67Single8EF6Morphine8EF6-μ-Morphine-Gi1/β1/γ2
16.67Single8GGYConstrained Epinephrine8GGY-β2-Constrained Epinephrine
16.67Single8H2GNiacin8H2G-HCA2-Niacin-Gi1/β1/γ2
16.67Single8HN1Toxin AdTx18HN1-Alpha1A-Toxin AdTx1
16.67Single8IULLatanoprost8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/β1/γ2
16.67Single8JILNiacin8JIL-HCA2-Niacin-Gi1/β1/γ2
16.67Single8JLOUlotaront8JLO-TA1-Ulotaront-Gs/β1/γ2
16.67Single8K5BNiacin8K5B-HCA2-Niacin
16.67Single8T3OTUG-8918T3O-FFA4-TUG-891-2Y5-chim(NtGi2L-Gs-CtGq)/β1/γ2
16.67Single8UO3Constrained Epinephrine8UO3-β2-Constrained Epinephrine-GTP; Mg-Gs/β1/γ2
16.67Single8UO4Constrained Epinephrine8UO4-β2-Constrained Epinephrine-GTP; Mg-Gs/β1/γ2
16.67Single8W89PEA8W89-TA1-PEA-chim(NtGi1L-Gs)/β1/γ2
16.67Single8XBES3E-LysoPS8XBE-GPR34-S3E-LysoPS-Gi1/β1/γ1
16.67Single8Y0NVUF114188Y0N-CXCR3-VUF11418-Go1/β1/γ2
16.67Single8YH3N-methyladenosine8YH3-A3A-N-methyladenosine-Gi1/β1/γ2
16.67Single8YN4Histamine8YN4-H2-Histamine-chim(NtGi1L-Gs-CtGq)/β1/γ2
16.67Single8YN5Histamine8YN5-H3-Histamine-Gi1/β1/γ2
16.67Single8YN6Imetit8YN6-H3-Imetit-Gi1/β1/γ2
16.67Single8YN7Immethridine8YN7-H3-Immethridine-Go1/β1/γ2
16.67Single8YUVImmepip8YUV-H3-Immepip-Gi1/β1/γ2
16.67Single8ZSVRO52633978ZSV-TA1-RO5263397-chim(NtGi1-Gs)/β1/γ2
16.67Single8ZX5AM2518ZX5-GPR55-AM251-chim(NtGi1-G13)/β1/γ2
16.67Single9B9Y7DY9B9Y-CB1-7DY
16.67Single9EPQ11,20-Ethanoretinal9EPQ-Rhodopsin-11,20-Ethanoretinal-chim(Gi1-CtGq)/β1/γ2
16.67Single9L3ZLRH7-C29L3Z-CML1-LRH7-C2
16.67Consensusbeta1_onOrthosteric Ligand8DCR-β1-Dobutamine-Gs/β1/γ2 7S0F-β1-Isoprenaline-Gi1/β1/γ2
16.67Consensusbeta1_on_gpOrthosteric Ligand8DCR-β1-Dobutamine-Gs/β1/γ2 7S0F-β1-Isoprenaline-Gi1/β1/γ2
16.67Consensusd3_offOrthosteric Ligand3PBL-D3-Eticlopride
16.67Consensusgq_nucleotideOrthosteric Ligandgq_p2y
16.67Consensusgq_p2yOrthosteric Ligand7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/β1/γ2
16.67Consensusneurotensin_offOrthosteric Ligandnts1_off
16.67Consensusnts1_offOrthosteric Ligand7UL2-NTS1-SR48692-Na
16.67Consensusorexin_on_gpOrthosteric Ligandox2_on_gp
16.67Consensusprostanoid_offOrthosteric Ligandep_off dp_off
16.22Consensusmc2_onOrthosteric Ligand8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1
16.22Consensusmc2_on_gpOrthosteric Ligand8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1
16.13Single5NX2GLP-1 (Truncated)5NX2-GLP-1-GLP-1 (Truncated)
16.13Single6B3JExendin-P56B3J-GLP-1-Exendin-P5-Gs/β1/γ2
16.13Single7F4FAfamelanotide7F4F-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2
16.13Single7F53Alpha-MSH7F53-MC4-α-MSH-Gs/β1/γ2
16.13Single7TYFAmylin7TYF-CT (AMY1)-Amylin-Gs/β1/γ2; RAMP1
16.13Single7VVKPTH7VVK-PTH1-PTH-Gs/β1/γ2
16.13Single7WVYAmyloid-Beta427WVY-FPR2-ALX-Amyloid-β42-Gi2/β1/γ2
16.13Single8FU6Glucagon derivative ZP37808FU6-Glucagon-Glucagon derivative ZP3780-Gs/β1/γ2
16.00Single5EE7MK08935EE7-Glucagon-MK0893
16.00Single6OMMWKYMVX6OMM-FPR2-ALX-WKYMVX-Gi1/β1/γ2
16.00Single6PT3DPI-2876PT3-δ-DPI-287
16.00Single7F9ZGHRP-67F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/β1/γ2
16.00Single7RKFFractalkine7RKF-US28-Fractalkine-GDP-chim(NtGi1-G11)/β1/γ2
16.00Single7RKNFractalkine7RKN-US28-Fractalkine-Gi1/β1/γ2
16.00Single7X8SWB4-247X8S-GLP-1-WB4-24-Gs/β1/γ2
16.00Single7XY6BAY 60-65837XY6-A2B-BAY 60-6583-chim(NtGi1-Gs)/β1/γ2
16.00Single7YJ4INSL57YJ4-RXFP4-INSL5-Gi2/β1/γ2
16.00Single8H4IDoconexent8H4I-FFA4-Doconexent-chim(NtGi1-Gs)/β1/γ2
16.00Single8IUMTafluprost acid8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/β1/γ2
16.00Single8SAI1-Oleoyl-2-Hydroxy-Sn-Glycero-3-Phospho-L-Serine8SAI-GPR34-1-Oleoyl-2-Hydroxy-Sn-Glycero-3-Phospho-L-Serine-Gi1/β1/γ2
16.00Single8X3LXWD8X3L-CB2-XWD-Gi1/β1/γ2
16.00Single8XZFWN5618XZF-Apelin-WN561-Gi1/β1/γ2
16.00Single9EAJNanobody AT2099EAJ-AT1-Nanobody AT209
16.00Single9ERXD9-THC analog9ERX-CB1-D9-THC analog-Gi1/β1/γ2
16.00Consensusnmur1_onOrthosteric Ligand7W53-NMUR1-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
15.79Single4S0VSuvorexant4S0V-OX2-Suvorexant
15.79Single5OLHVipadenant5OLH-A2A-Vipadenant-Na
15.79Single5U09Taranabant5U09-CB1-Taranabant
15.79Single6AKXA4R6AKX-CCR5-A4R
15.79Single6DS0Ly2660976DS0-5-HT2B-Ly266097
15.79Single6FKBPubChem 1324730386FKB-Rhodopsin-PubChem 132473038
15.79Single6OBAS-Alprenolol6OBA-β2-S-Alprenolol-GTPL11074
15.79Single6OYAAll-trans-Retinal6OYA-Rhodopsin-All-trans-Retinal-Gt/β1/γ1
15.79Single6TODEMPA6TOD-OX1-EMPA-Na
15.79Single6TPJSuvorexant6TPJ-OX2-Suvorexant
15.79Single6WWZCCL206WWZ-CCR6-CCL20-Go/β1/γ2
15.79Single6ZA8RTI-3a6ZA8-NTS1-RTI-3a
15.79Single7DHRIsoprenaline7DHR-β2-Isoprenaline-Gs/β1/γ2
15.79Single7EJ0L-Norepinephrine7EJ0-α2a-L-Norepinephrine-Go/β1/γ2
15.79Single7F8YDevazepide7F8Y-CCKA-Devazepide
15.79Single7LCJDanuglipron7LCJ-GLP-1-Danuglipron
15.79Single7LJDDopamine7LJD-D1-Dopamine-Mevidalen-Gs/β1/γ1
15.79Single7SRRLSD7SRR-5-HT2B-LSD-chim(NtGi2L-Gs-CtGq)/β1/γ2
15.79Single7SRSLSD7SRS-5-HT2B-LSD-Arrestin2
15.79Single7T8XAcetylcholine7T8X-M2-Acetylcholine-chim(NtGi1-Go)/β1/γ2
15.79Single7T90Acetylcholine7T90-M2-Acetylcholine-chim(NtGi1-Go)/β1/γ2
15.79Single7T96Acetylcholine7T96-M2-Acetylcholine-LY2119620-Go/β1/γ2
15.79Single7VIHCBP-3077VIH-S1P1-CBP-307-Gi1/β1/γ2
15.79Single7W0MPubChem 1227019087W0M-Apelin-PubChem 122701908-Gi1/β1/γ2
15.79Single7W0OElabela7W0O-Apelin-Elabela-Gi1/β1/γ2
15.79Single7X2FDopamine7X2F-D1-Dopamine-Mevidalen-Gs/β1/γ2
15.79Single7YMHNorepinephrine7YMH-Alpha1A-Norepinephrine-chim(Gs-CtGq)
15.79Single8GGAConstrained Epinephrine8GGA-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
15.79Single8GGCConstrained Epinephrine8GGC-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
15.79Single8GGRConstrained Epinephrine8GGR-β2-Constrained Epinephrine
15.79Single8GGWConstrained Epinephrine8GGW-β2-Constrained Epinephrine
15.79Single8GH0Constrained Epinephrine8GH0-β2-Constrained Epinephrine
15.79Single8HOCImetit8HOC-H4-Imetit-Gi1/β1/γ2
15.79Single8IJANiacin8IJA-HCA2-Niacin-Gi1/β1/γ2
15.79Single8J6LNiacin8J6L-HCA2-Niacin-Gi1/β1/γ2
15.79Single8JSOAMPH8JSO-TA1-AMPH-chim(NtGi1-Gs)/β1/γ2
15.79Single8TZQL-Dopamine8TZQ-D2-L-Dopamine-Go/β1/γ2
15.79Single8U4SREGN7663-Fab8U4S-CXCR4-REGN7663-Fab
15.79Single8U4TREGN7663-Fab8U4T-CXCR4-REGN7663-Fab
15.79Single8WC4ZH86518WC4-TA1-ZH8651-chim(NtGi1-Gs)/β1/γ2
15.79Single8WCA2-Phenylethylamine8WCA-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/β1/γ2
15.79Single8XXVIndomethacin8XXV-DP2-Indomethacin-A1D5Q-Gi1/β1/γ2
15.79Single8Y0HVUF114188Y0H-CXCR3-VUF11418
15.79Single8YNAImmepip8YNA-H4-Immepip-Gi1/β1/γ
15.79Single8YUTAmthamine8YUT-H2-Amthamine-Gs/β1/γ2
15.79Single9BA0A1AKN9BA0-CB1-A1AKN
15.79Single9MQJIsoquinuclidine9MQJ-μ-Isoquinuclidine
15.79Consensus5ht2_on_gpOrthosteric Ligand5ht2b_on_gp
15.79Consensus5ht2b_on_gpOrthosteric Ligand7SRR-5-HT2B-LSD-chim(NtGi2L-Gs-CtGq)/β1/γ2
15.79Consensusccr6_onOrthosteric Ligand6WWZ-CCR6-CCL20-Go/β1/γ2
15.79Consensusccr6_on_gpOrthosteric Ligand6WWZ-CCR6-CCL20-Go/β1/γ2
15.79Consensushistamine_onOrthosteric Ligandh1_on h2_on h3_on h4_on
15.79Consensushistamine_on_gpOrthosteric Ligandh1_on_gp h2_on_gp h3_on_gp h4_on_gp
15.79Consensusm2_onOrthosteric Ligand7T8X-M2-Acetylcholine-chim(NtGi1-Go)/β1/γ2
15.79Consensusm2_on_gpOrthosteric Ligand7T8X-M2-Acetylcholine-chim(NtGi1-Go)/β1/γ2
15.79Consensusorexin_offOrthosteric Ligandox2_off ox1_off
15.79Consensusox2_offOrthosteric Ligand5WQC-OX2-EMPA 6TPN-OX2-HTL6641 7XRR-OX2-Lemborexant 6TPJ-OX2-Suvorexant
15.79Consensusrhodopsin_on_gpOrthosteric Ligand6OYA-Rhodopsin-All-trans-Retinal-Gt/β1/γ1
15.62Single6LMLGlucagon6LML-Glucagon-Glucagon-Gi1/β1/γ1
15.62Single7TS0Urocortin7TS0-CRF2-Urocortin-chim(NtGi1L-Go)/β1/γ2
15.62Single7TYLAmylin7TYL-CT-Amylin-Gs/β1/γ2
15.62Single8F0KPramlintide Analogue San3858F0K-CT (AMY3)-Pramlintide Analogue San385-Gs/β1/γ2; RAMP3
15.38Single4XT1Fractalkine4XT1-US28-Fractalkine
15.38Single6WIVPubChem 52923113; PubChem 529246456WIV-GABAB1, GABAB2-PubChem 52923113; PubChem 52924645
15.38Single7F4ISHU91197F4I-MC1-SHU9119-chim(NtGi1-Gs)/β1/γ2
15.38Single7QA8Peptide7QA8-STE2-Peptide
15.38Single7QA8Peptide7QA8-STE2-Peptide
15.38Single7TD4Siponimod7TD4-S1P1-Siponimod-Gi1/β1/γ2
15.38Single7XMRSomatostatin-147XMR-SST2-Somatostatin-14-Gi1/β1/γ2
15.38Single8DCRDobutamine8DCR-β1-Dobutamine-Gs/β1/γ2
15.38Single8DWGProenkephalin-A8DWG-MRGPRX1-Proenkephalin-A-ML382-chim(NtGi2L-Gs-CtGq)/β1/γ2
15.38Single8FYLVilazodone8FYL-5-HT1A-Vilazodone-Gi1/β1/γ1
15.38Single8GHVAMG3158GHV-CB1-AMG315-Gi1/β1/γ2
15.38Single8IEIA1LYA8IEI-GPR156-A1LYA
15.38Single8IEPA1LYA8IEP-GPR156-A1LYA
15.38Single8IEPA1LYA8IEP-GPR156-A1LYA
15.38Single8J6RMK68928J6R-HCA2-MK6892-Gi1/β1/γ2
15.38Single8U4OCXCL128U4O-CXCR4-CXCL12-Cholesterol-Gi1/β1/γ2
15.38Single8XBHS3E-LysoPS8XBH-GPR34-S3E-LysoPS-Gi1/β1/γ2
15.38Consensuschemokine_onOrthosteric Ligandccr_on cxcr_on
15.38Consensusmc4_onOrthosteric Ligand7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2 7F58-MC4-THIQ-Gs/β1/γ2 7F54-MC4-Afamelanotide-Gs/β1/γ2 7F53-MC4-α-MSH-Gs/β1/γ2 7F55-MC4-Bremelanotide-Gs/β1/γ2
15.15Single7TYXAmylin7TYX-CT (AMY2)-Amylin-Gs/β1/γ2; RAMP2
15.15Single8U1UCCL18U1U-CCR8-CCL1-Gi1/β1/γ2
15.15Single8ZJETAK-4488ZJE-Kiss1-TAK-448-chim(NtGi1-Gq)/β1/γ1
15.00Single3REYXAC3REY-A2A-XAC
15.00Single3RZECidoxepin3RZE-H1-Cidoxepin
15.00Single3UZC4-(3-amino-5-phenyl-1,2,4-triazin-6-yl)-2-chlorophenol3UZC-A2A-4-(3-amino-5-phenyl-1,2,4-triazin-6-yl)-2-chlorophenol
15.00Single4DKLBeta-Funaltrexamine4DKL-μ-β-Funaltrexamine
15.00Single4MBSMaraviroc4MBS-CCR5-Maraviroc
15.00Single4ZJCSB-6740424ZJC-OX1-SB-674042
15.00Single6A94Zotepine6A94-5-HT2A-Zotepine
15.00Single6FFIMMPEP6FFI-mGlu5-MMPEP
15.00Single6FK8PubChem 1324730356FK8-Rhodopsin-PubChem 132473035
15.00Single6FKAPubChem 1324730376FKA-Rhodopsin-PubChem 132473037
15.00Single6K41Dexmedetomidine6K41-α2b-Dexmedetomidine-Go/β1/γ2
15.00Single6KUXRS-799486KUX-α2a-RS-79948
15.00Single6PELCitronellol6PEL-Rhodopsin-Citronellol-Gt(CT)
15.00Single6TOSGSK10598656TOS-OX1-GSK1059865-Na
15.00Single6TP3Nemorexant6TP3-OX1-Nemorexant
15.00Single6TPGEMPA6TPG-OX2-EMPA
15.00Single6TPKRetosiban6TPK-OT-Retosiban
15.00Single6TPNHTL66416TPN-OX2-HTL6641
15.00Single6V9SGTPL114036V9S-OX1-GTPL11403
15.00Single6WH4Methiothepin6WH4-5-HT2A-Methiothepin
15.00Single6WJCAtropine6WJC-M1-Atropine-Muscarinic toxin 7
15.00Single7C2EPubChem 1490507997C2E-GLP-1-PubChem 149050799-Gs/β1/γ2
15.00Single7CMUPramipexole7CMU-D3-Pramipexole-Gi1/β1/γ2
15.00Single7DHISalbutamol7DHI-β2-Salbutamol-Gs/β1/γ2
15.00Single7E33BRL-544437E33-5-HT1E-BRL-54443-Gi1/β1/γ2
15.00Single7EJADexmedetomidine7EJA-α2a-Dexmedetomidine-Go/β1/γ2
15.00Single7F24Dopamine7F24-D1-Dopamine-GDP-Gs/β1/γ2
15.00Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
15.00Single7RANPubChem 1645758477RAN-5-HT2A-PubChem 164575847-chim(NtGi2L-Gs-CtGq)/β1/γ2
15.00Single7SR8TAK-9257SR8-OX2-TAK-925-chim(NtGi1L-Gs-CtGq)/β1/γ2
15.00Single7T94Acetylcholine7T94-M2-Acetylcholine-PubChem 57664406-chim(NtGi1-Go)/β1/γ2
15.00Single7TRSAcetylcholine7TRS-M4-Acetylcholine-Gi1/β1/γ2
15.00Single7VODCariprazine7VOD-5-HT2A-Cariprazine
15.00Single8GE1Constrained Epinephrine8GE1-β2-Constrained Epinephrine-Gs/β1/γ2
15.00Single8GE4Constrained Epinephrine8GE4-β2-Constrained Epinephrine-Gs/β1/γ2
15.00Single8GE6Constrained Epinephrine8GE6-β2-Constrained Epinephrine-Gs/β1/γ2
15.00Single8GE7Constrained Epinephrine8GE7-β2-Constrained Epinephrine-Gs/β1/γ2
15.00Single8GE8Constrained Epinephrine8GE8-β2-Constrained Epinephrine-Gs/β1/γ2
15.00Single8GEAConstrained Epinephrine8GEA-β2-Constrained Epinephrine-Gs/β1/γ2
15.00Single8GEFConstrained Epinephrine8GEF-β2-Constrained Epinephrine-Gs/β1/γ2
15.00Single8GG8Constrained Epinephrine8GG8-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
15.00Single8GGSConstrained Epinephrine8GGS-β2-Constrained Epinephrine
15.00Single8GGTConstrained Epinephrine8GGT-β2-Constrained Epinephrine
15.00Single8GGVConstrained Epinephrine8GGV-β2-Constrained Epinephrine
15.00Single8HNMVUF112228HNM-CXCR3-VUF11222-Gi1/β1/γ2
15.00Single8IHKAcifran8IHK-HCA3-Acifran
15.00Single8JLKUlotaront8JLK-TA1-Ulotaront-chim(NtGi1-Gs)/β1/γ2
15.00Single8JLNT1AM8JLN-TA1-T1AM-Gs/β1/γ2
15.00Single8JSPUlotaront8JSP-5-HT1A-Ulotaront-Gi1/β1/γ2
15.00Single8K5CAcipimox8K5C-HCA2-Acipimox
15.00Single8K9KDamgo8K9K-μ-Damgo-Gi3/β1/γ1
15.00Single8K9LDamgo8K9L-μ-Damgo-VV9-Gi3/β1/γ1
15.00Single8PM2DMCH8PM2-TA7-DMCH-Gs/β1/γ2
15.00Single8THLEpinephrine8THL-Alpha1A-Epinephrine-chim(NtGi2L-Gs-CtGq)/β1/γ2
15.00Single8U02L-Dopamine8U02-D2-L-Dopamine-Go/β1/γ2
15.00Single8V6UPubChem 1713924568V6U-5-HT2A-PubChem 171392456-chim(NtGi2-Gs-CtGq)/β1/γ2
15.00Single8VVGGB188VVG-κ-GB18-Gi1/β1/γ2
15.00Single8W8BSEP-3638568W8B-5-HT1A-SEP-363856-Gi1/β1/γ2
15.00Single8WC8ZH86518WC8-TA1-ZH8651-chim(NtGi1-Gs)/β1/γ2
15.00Single8Y01Retinal8Y01-Opsin1MW-Retinal-Gi1/β1/γ2
15.00Single8Y62C16:0 Ceramide8Y62-FPR2-ALX-C16:0 Ceramide-Gi1/β1/γ2
15.00Single8YN3Histamine8YN3-H2-Histamine-Gs/β1/γ2
15.00Single8YN8Proxyfan8YN8-H3-Proxyfan-Go1/β1/γ2
15.00Single9ASBCa; Ca; Cyclomethyltryptophan; 9IG; PO49ASB-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
15.00Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
15.00Single9BJKNaloxone9BJK-μ-Naloxone-NAM
15.00Single9EPP11,20-Ethanoretinal9EPP-Rhodopsin-11,20-Ethanoretinal-chim(Gi1-CtGq)/β1/γ2
15.00Single9K1DButanoic acid9K1D-FFA2-Butanoic acid-Cholesterol-Gi1/β1/γ2
15.00Single9MQIIsoquinuclidine9MQI-μ-Isoquinuclidine
15.00Consensus5ht2a_offOrthosteric Ligand6A94-5-HT2A-Zotepine 6A93-5-HT2A-Risperidone 7VOD-5-HT2A-Cariprazine 7WC8-5-HT2A-Lumateperone 8JT8-5-HT2A-(R)-IHCH-7179
15.00Consensusalpha1_onOrthosteric Ligandalpha1a_on
15.00Consensusalpha1_on_gpOrthosteric Ligandalpha1a_on_gp
15.00Consensusalpha1a_onOrthosteric Ligand7EJ0-α2a-L-Norepinephrine-Go/β1/γ2 7EJ8-α2a-Brimonidine-Go/β1/γ2 7EJA-α2a-Dexmedetomidine-Go/β1/γ2 7EJK-α2a-Oxymetazoline-Go/β1/γ2 7W6P-α2a-N-pyridin-4-ylisoquinolin-4-amine-Go/β1/γ2 7W7E-α2a-PubChem 164946676-Go/β1/γ2
15.00Consensusalpha1a_on_gpOrthosteric Ligand7EJ0-α2a-L-Norepinephrine-Go/β1/γ2 7EJ8-α2a-Brimonidine-Go/β1/γ2 7EJA-α2a-Dexmedetomidine-Go/β1/γ2 7EJK-α2a-Oxymetazoline-Go/β1/γ2 7W6P-α2a-N-pyridin-4-ylisoquinolin-4-amine-Go/β1/γ2 7W7E-α2a-PubChem 164946676-Go/β1/γ2
15.00Consensusd3_onOrthosteric Ligand7CMV-D3-PD128907-Gi1/β1/γ2 8IRT-D3-Rotigotine-Gi1/β1/γ2 7CMU-D3-Pramipexole-Gi1/β1/γ2
15.00Consensusd3_on_gpOrthosteric Ligand7CMV-D3-PD128907-Gi1/β1/γ2 8IRT-D3-Rotigotine-Gi1/β1/γ2 7CMU-D3-Pramipexole-Gi1/β1/γ2
15.00Consensusghrelin_offOrthosteric Ligand6KO5-Ghrelin-PubChem 57400002 7F83-Ghrelin-PF-05190457
15.00Consensusot_offOrthosteric Ligand6TPK-OT-Retosiban
15.00Consensusvasop-oxy_offOrthosteric Ligandot_off
14.81Single6HLOAprepitant6HLO-NK1-Aprepitant
14.81Single7CUMPhospholipid7CUM-GABAB1, GABAB2-CGP54626-Phospholipid
14.81Single7PIVSetmelanotide7PIV-MC4-Setmelanotide-Gs/β1/γ2
14.81Single7RKMFractalkine7RKM-US28-Fractalkine-Gi1/β1/γ2
14.81Single7W0NElabela7W0N-Apelin-Elabela-Gi1/β1/γ2
14.81Single8F7WDynorphin8F7W-κ-Dynorphin-Gi1/β1/γ2
14.81Consensusmc4_on_gpOrthosteric Ligand7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2 7F58-MC4-THIQ-Gs/β1/γ2 7F54-MC4-Afamelanotide-Gs/β1/γ2 7F53-MC4-α-MSH-Gs/β1/γ2 7F55-MC4-Bremelanotide-Gs/β1/γ2
14.71Single7TZFAmylin7TZF-CT (AMY3)-Amylin-Gs/β1/γ2; RAMP3
14.71Single7VBHPeptide-207VBH-GLP-1-Peptide-20-Gs/β1/γ2
14.71Single9AUCCalcitonin gene-related peptide-19AUC-CT (AMY1)-Calcitonin gene-related peptide-1-Gs/β1/γ2; RAMP1
14.29Single2VT4Cyanopindolol2VT4-β1-Cyanopindolol
14.29Single2Y04Salbutamol2Y04-β1-Salbutamol
14.29Single2YCYCyanopindolol2YCY-β1-Cyanopindolol
14.29Single3ZPR4-methyl-2-(piperazin-1-yl)3ZPR-β1-4-methyl-2-(piperazin-1-yl)-Na
14.29Single4DAJTiotropium4DAJ-M3-Tiotropium
14.29Single4MQSIperoxo4MQS-M2-Iperoxo
14.29Single4QKX35V4QKX-β2-35V
14.29Single4U14Tiotropium4U14-M3-Tiotropium
14.29Single4U16N-Methyl-Scopolamine4U16-M3-N-Methyl-Scopolamine
14.29Single5DSGTiotropium5DSG-M4-Tiotropium
14.29Single5UIGCmpd-15UIG-A2A-Cmpd-1
14.29Single5YC8N-Methyl-Scopolamine5YC8-M2-N-Methyl-Scopolamine
14.29Single5ZK8N-Methyl-Scopolamine5ZK8-M2-N-Methyl-Scopolamine
14.29Single5ZKCN-Methyl-Scopolamine5ZKC-M2-N-Methyl-Scopolamine
14.29Single6DRXLisuride6DRX-5-HT2B-Lisuride
14.29Single6FFHFenobam6FFH-mGlu5-Fenobam
14.29Single6FK7PubChem 1324730346FK7-Rhodopsin-PubChem 132473034
14.29Single6FKDPubChem 1373491836FKD-Rhodopsin-PubChem 137349183
14.29Single6H7MSalbutamol6H7M-β1-Salbutamol
14.29Single6K42Dexmedetomidine6K42-α2b-Dexmedetomidine-Gi1/β1/γ2
14.29Single6PRZS-Alprenolol6PRZ-β2-S-Alprenolol
14.29Single6UUNAdrenomedullin6UUN-CT Like (AM1)-Adrenomedullin-Gs/β1/γ2; RAMP2
14.29Single6WHADB139486WHA-5-HT2A-DB13948-chim(NtGi2L-Gs-CtGq)/β1/γ2
14.29Single6X1ADanuglipron6X1A-GLP-1-Danuglipron-Gs/β1/γ2
14.29Single7BU7BI1671077BU7-β1-BI167107
14.29Single7LCIDanuglipron7LCI-GLP-1-Danuglipron-Gs/β1/γ2
14.29Single7LCKDanuglipron7LCK-GLP-1-Danuglipron
14.29Single7M3JNPS-2143; PO47M3J-CaS-NPS-2143; PO4
14.29Single7O7F6P4-CCL57O7F-CCR5-6P4-CCL5-Gi1/β1/γ1
14.29Single7PP1Selatogrel7PP1-P2Y12-Selatogrel
14.29Single7SCGFH2107SCG-μ-FH210-Gi1/β1/γ2
14.29Single7SQOTAK-9257SQO-OX2-TAK-925-Gi1/β1/γ2
14.29Single7T2GMitragynine Pseudoindoxyl7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2
14.29Single7T6VfMLFII7T6V-FPR2-ALX-fMLFII-Gi1/β1/γ2
14.29Single7TRPIperoxo7TRP-M4-Iperoxo-LY2033298-Gi1/β1/γ2
14.29Single7TRQVU04671547TRQ-M4-Iperoxo-VU0467154-Gi1/β1/γ2
14.29Single7V35Peptide-207V35-Glucagon-Peptide-20-Gs/β1/γ2
14.29Single7VH0Ramelteon7VH0-MT2-Ramelteon-Gi1/β1/γ1
14.29Single7VIFS-FTY720-P7VIF-S1P1-S-FTY720-P-Gi1/β1/γ2
14.29Single7WC7Lisuride7WC7-5-HT2A-Lisuride
14.29Single7WC8Lumateperone7WC8-5-HT2A-Lumateperone
14.29Single7XJHIsoproterenol7XJH-β3-Isoproterenol-Gs/β1/γ2
14.29Single7YU4ONO-07405567YU4-LPA1-ONO-0740556
14.29Single8CICEtrumadenant8CIC-A2A-Etrumadenant-Na
14.29Single8FY85-MeO-DMT8FY8-5-HT1A-5-MeO-DMT-Gi1/β1/γ1
14.29Single8GE9Constrained Epinephrine8GE9-β2-Constrained Epinephrine-Gs/β1/γ2
14.29Single8I7VAcipimox8I7V-HCA2-Acipimox-Gi1/β1/γ2
14.29Single8IHJAcifran8IHJ-HCA3-Acifran-Gi1/β1/γ2
14.29Single8IRTRotigotine8IRT-D3-Rotigotine-Gi1/β1/γ2
14.29Single8JD0NAM5638JD0-mGlu2; mGlu3-Glutamate-NAM563
14.29Single8JIPMEDI03828JIP-GLP-1-MEDI0382-chim(NtGi1-Gs)/β1/γ2
14.29Single8K5DGSK2560738K5D-HCA2-GSK256073
14.29Single8KEXDCA-3P8KEX-MRGPRX4-DCA-3P
14.29Single8PJKST1718PJK-5-HT1A-ST171-t7m-Gi1/β1/γ1
14.29Single8RLNLUF58348RLN-A2A-LUF5834
14.29Single8T1WCVN4248T1W-GPR6-CVN424
14.29Single8UWLLisuride8UWL-5-HT2A-Lisuride-chim(NtGi2-Gs-CtGq)/β1/γ2
14.29Single8W87METH8W87-TA1-METH-chim(NtGi1L-Gs)/β1/γ2
14.29Single8WKZSBL-MC-318WKZ-MC4-SBL-MC-31
14.29Single8X63Mepyramine8X63-H1-Mepyramine
14.29Single8X64Desloratadine8X64-H1-Desloratadine
14.29Single8XBGS3E-LysoPS8XBG-GPR34-S3E-LysoPS
14.29Single8XVKAmbrisentan8XVK-ETA-Ambrisentan
14.29Single8XZGApelin-138XZG-Apelin-Apelin-13-Gi1/β1/γ2
14.29Single8Y63C20:0 Ceramide8Y63-FPR2-ALX-C20:0 Ceramide-Gi1/β1/γ2
14.29Single8YICSAR2477998YIC-S1P1-SAR247799-Gi1/β1/γ2
14.29Single9B9ZA1AKO9B9Z-CB1-A1AKO
14.29Single9CBMDexmedetomidine9CBM-α2a-Dexmedetomidine-Gi1/β1/γ2
14.29Single9IYAONO-97105319IYA-GPR55-ONO-9710531
14.29Consensusalicarboxylic_on_gpOrthosteric Ligandsuccinate_on_gp hca_on_gp
14.29Consensusalpha2_onOrthosteric Ligandalpha2b_on
14.29Consensusalpha2_on_gpOrthosteric Ligandalpha2b_on_gp
14.29Consensusalpha2b_onOrthosteric Ligand6K42-α2b-Dexmedetomidine-Gi1/β1/γ2
14.29Consensusalpha2b_on_gpOrthosteric Ligand6K42-α2b-Dexmedetomidine-Gi1/β1/γ2
14.29Consensusalpha_onOrthosteric Ligandalpha1_on alpha2_on
14.29Consensusd5_onOrthosteric Ligand8IRV-D5-Rotigotine-chim(NtGi1-Gs)/β1/γ2
14.29Consensusgi_alicarboxylicOrthosteric Ligandgi_hca gi_succinate
14.29Consensusgi_histamineOrthosteric Ligand8JXX-H4-Clobenpropit-Gi1/β1/γ2 8JXV-H4-Clozapine-Gi1/β1/γ2 8YUU-H3-Histamine-Gi1/β1/γ1 8HN8-H4-Histamine-Gi1/β1/γ2 8HOC-H4-Imetit-Gi1/β1/γ2 8JXW-H4-VUF6884-Gi1/β1/γ2
14.29Consensusgi_orexinOrthosteric Ligand7SQO-OX2-TAK-925-Gi1/β1/γ2
14.29Consensusgs_trace-amineOrthosteric Ligand8W88-TA1-SEP-363856-Gs/β1/γ2 8JLJ-TA1-T1AM-chim(NtGi1-Gs)/β1/γ2 8JLO-TA1-Ulotaront-Gs/β1/γ2 8WC4-TA1-ZH8651-chim(NtGi1-Gs)/β1/γ2 8WC7-TA1-ZH8667-chim(NtGi1-Gs)/β1/γ2 8JLR-TA1-A77636-chim(NtGi1-Gs)/β1/γ2 8JSO-TA1-AMPH-chim(NtGi1-Gs)/β1/γ2 8W87-TA1-METH-chim(NtGi1L-Gs)/β1/γ2 8W89-TA1-PEA-chim(NtGi1L-Gs)/β1/γ2 8JLP-TA1-Ralmitaront-Gs/β1/γ2 8W8A-TA1-RO5256390-chim(NtGi1L-Gs)/β1/γ2
14.29Consensushistamine_offOrthosteric Ligandh1_off
14.29Consensusm4_offOrthosteric Ligand5DSG-M4-Tiotropium
14.29Consensusmuscarinic_onOrthosteric Ligandm2_on m3_on m4_on m1_on
14.29Consensusmuscarinic_on_gpOrthosteric Ligandm2_on_gp m3_on_gp m4_on_gp m1_on_gp
13.95Single8GY7Corticotropin8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1
13.79Single6M1IPACAP6M1I-PAC1-PACAP-Gs/β1/γ2
13.79Single6WI9Secretin6WI9-Secretin-Secretin-Gs/β1/γ2
13.79Single6WIVPubChem 52923113; PubChem 529246456WIV-GABAB1, GABAB2-PubChem 52923113; PubChem 52924645
13.79Single7V9MSomatoliberin7V9M-GHRH (SV1)-Somatoliberin-Gs/β1/γ2
13.79Single8IHFMK68928IHF-HCA2-MK6892-Gi1/β1/γ2
13.79Single8J6IMK68928J6I-HCA2-MK6892-Gi1/β1/γ2
13.79Single8YW4Retatrutide8YW4-GIP-Retatrutide-chim(NtGi1-Gs)/β1/γ22
13.64Single2Y03Isoprenaline2Y03-β1-Isoprenaline
13.64Single4NTJAZD12834NTJ-P2Y12-AZD1283
13.64Single4WW3All-trans-Retinal4WW3-Rhodopsin-All-trans-Retinal
13.64Single5WIUNemonapride5WIU-D4-Nemonapride
13.64Single5WIVNemonapride5WIV-D4-Nemonapride-Na
13.64Single5WQCEMPA5WQC-OX2-EMPA
13.64Single6LUQHaloperidol6LUQ-D2-Haloperidol
13.64Single6OIKIperoxo6OIK-M2-Iperoxo-LY2119620-chim(NtGi1-Go)/β1/γ2
13.64Single6RZ4Pranlukast6RZ4-CysLT1-Pranlukast-Na
13.64Single6W2XPubChem 237279706W2X-GABAB1, GABAB2-PubChem 5311042-PubChem 23727970
13.64Single6Z4QSR142948A6Z4Q-NTS1-SR142948A
13.64Single6Z4SSR486926Z4S-NTS1-SR48692
13.64Single7EUOfMLF7EUO-FPR1-ALX-fMLF-Gi1/β1/γ2
13.64Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
13.64Single7M3JNPS-2143; PO47M3J-CaS-NPS-2143; PO4
13.64Single7SINNPS-21437SIN-CaS-NPS-2143
13.64Single7SINNPS-21437SIN-CaS-NPS-2143
13.64Single7TD3S1P7TD3-S1P1-S1P-Gi1/β1/γ2
13.64Single7TRKIperoxo7TRK-M4-Iperoxo-Gi1/β1/γ2
13.64Single7VOEAripiprazole7VOE-5-HT2A-Aripiprazole
13.64Single7VV4Cortistatin-147VV4-MRGPRX2-Cortistatin-14
13.64Single7WC6LSD7WC6-5-HT2A-LSD
13.64Single7YU3ONO-07405567YU3-LPA1-ONO-0740556-Gi1/β1/γ2
13.64Single7YU6ONO-07405567YU6-LPA1-ONO-0740556-Gi1/β1/γ2
13.64Single8DZQmomSalB8DZQ-κ-momSalB-Go/β1/γ2
13.64Single8DZRGR89,6968DZR-κ-GR89,696-chim(NtGi2-Gt3)/β1/γ2
13.64Single8E9ZIperoxo8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/β1/γ2
13.64Single8EFBOliceridine8EFB-μ-Oliceridine-Gi1/β1/γ2
13.64Single8EJCTAK-8758EJC-FFA1-TAK-875-chim(NtGi1L-Gs-CtGq)/β1/γ2
13.64Single8GDCPGE28GDC-EP3-PGE2-Gi1/β1/γ2
13.64Single8HNLPS3724248HNL-CXCR3-PS372424-Gi1/β1/γ2
13.64Single8I7WGSK2560738I7W-HCA2-GSK256073-Gi1/β1/γ2
13.64Single8J6JGSK2560738J6J-HCA2-GSK256073-Gi1/β1/γ2
13.64Single8JXSPF-61428JXS-D1-PF-6142
13.64Single8K8JFenofibrate8K8J-CB1-Fenofibrate-chim(Gs-CtGq)/β1/γ2
13.64Single8SZICa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZI-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi3/β1/γ2
13.64Single8TH4AT118-L Nanobody8TH4-AT1-Losartan-AT118-L Nanobody
13.64Single8WGBW9R8WGB-mGlu4; mGlu2-Glutammate-W9R-Gi3/β1/γ2
13.64Single8X0BVU04244658X0B-mGlu5; mGlu5-Quisqualate-VU0424465
13.64Single8X0CVU04244658X0C-mGlu5; mGlu5-Quisqualate-VU0424465
13.64Single8XYKVUF106618XYK-CXCR3-VUF10661-Go1/β1/γ2
13.64Single8ZMFA1L108ZMF-5-HT2C-A1L10
13.64Single8ZRKGSK-12922638ZRK-GPR119-GSK-1292263-Gs/β1/γ2
13.64Single9AVLCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVL-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi3/β2/γ2
13.64Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
13.64Single9DQJEP-39459DQJ-MRGPRD-EP-3945-chim(NtGi1-Gs-CtGq)/β1/γ2
13.64Single9MQKIsoquinuclidine9MQK-κ-Isoquinuclidine
13.64Consensus5ht2_offOrthosteric Ligand5ht2a_off 5ht2b_off 5ht2c_off
13.64Consensusalpha_on_gpOrthosteric Ligandalpha1_on_gp alpha2_on_gp
13.64Consensusd4_onOrthosteric Ligand8IRU-D4-Rotigotine-chim(NtGi1-Gs-CtGi1)/β1/γ2
13.64Consensusgq_muscarinicOrthosteric Ligand6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/β1/γ2
13.64Consensush1_offOrthosteric Ligand8X63-H1-Mepyramine 3RZE-H1-Cidoxepin 8X5Y-H1-Astemizole
13.64Consensusm1_onOrthosteric Ligand6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/β1/γ2
13.64Consensusm2_offOrthosteric Ligand5ZKC-M2-N-Methyl-Scopolamine 5ZK3-M2-3-quinuclidinyl-benzilate 5ZKB-M2-AF-DX 384
13.64Consensusm3_onOrthosteric Ligand8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/β1/γ2 8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/β1/γ2 8E9Y-M3-Clozapine-N-oxide-chim(NtGi2L-Gs-CtGq)/β1/γ2
13.64Consensusm3_on_gpOrthosteric Ligand8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/β1/γ2 8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/β1/γ2 8E9Y-M3-Clozapine-N-oxide-chim(NtGi2L-Gs-CtGq)/β1/γ2
13.64Consensusrxfp4_onOrthosteric Ligand7YK7-RXFP4-DC591053-Gi2/β1/γ2 7YJ4-RXFP4-INSL5-Gi2/β1/γ2 7YK6-RXFP4-PubChem 138319674-Gi2/β1/γ2
13.64Consensusrxfp4_on_gpOrthosteric Ligand7YK7-RXFP4-DC591053-Gi2/β1/γ2 7YJ4-RXFP4-INSL5-Gi2/β1/γ2 7YK6-RXFP4-PubChem 138319674-Gi2/β1/γ2
13.33Single8GEJConstrained Epinephrine8GEJ-β2-Constrained Epinephrine-Gs/β1/γ2
13.33Single8IODPG-9018IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/β1/γ2
13.33Single8WCBCyclohexylammonium Ion8WCB-TA1-Cyclohexylammonium Ion-chim(NtGi1-Gs-CtGq)/β1/γ2
13.33Single8WCCCyclohexylammonium Ion8WCC-TA1-Cyclohexylammonium Ion
13.33Single8XOFLys058XOF-GPR30-Lys05-chim(NtGi1-Gs-CtGq)/β1/γ2
13.33Consensuschemokine_offOrthosteric Ligandccr_off cxcr_off
13.04Single3PDSHydroxybenzylisoproterenol3PDS-β2-Hydroxybenzylisoproterenol
13.04Single4LDLHydroxybenzylisoproterenol4LDL-β2-Hydroxybenzylisoproterenol
13.04Single4OO9Mavoglurant4OO9-mGlu5-Mavoglurant
13.04Single4U15Tiotropium4U15-M3-Tiotropium
13.04Single5TZRMK86665TZR-FFA1-MK8666
13.04Single5V54Methiothepin5V54-5-HT1B-Methiothepin
13.04Single5XRAAM115425XRA-CB1-AM11542
13.04Single5ZKBAF-DX 3845ZKB-M2-AF-DX 384
13.04Single6E59L-7607356E59-NK1-L-760735
13.04Single6OIJIperoxo6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/β1/γ2
13.04Single6OL9Tiotropium6OL9-M5-Tiotropium
13.04Single6TQ7SB-3348676TQ7-OX1-SB-334867
13.04Single7EW1Siponimod7EW1-S1P5-Siponimod-Gi1/β1/γ2
13.04Single7EW4CYM55417EW4-S1P3-CYM5541-Gi1/β1/γ2
13.04Single7M8W15r-Methyl-Prostaglandin D27M8W-DP2-15r-Methyl-Prostaglandin D2-Na
13.04Single7P2L4YI7P2L-mGlu5-4YI
13.04Single7S8MCortistatin-147S8M-MRGPRX2-Cortistatin-14-Gi1/β1/γ2
13.04Single7T2HLofentanil7T2H-μ-Lofentanil-Gi1/β1/γ2
13.04Single7TD1LPA7TD1-LPA1-LPA-Gi1/β1/γ2
13.04Single7TRQIperoxo7TRQ-M4-Iperoxo-VU0467154-Gi1/β1/γ2
13.04Single7U2LPubChem 1632012427U2L-μ-PubChem 163201242-Gi1/β1/γ2
13.04Single7YU5ONO-07405567YU5-LPA1-ONO-0740556-Gi1/β1/γ2
13.04Single7YU7ONO-07405567YU7-LPA1-ONO-0740556-Gi1/β1/γ2
13.04Single8DZPmomSalB8DZP-κ-momSalB-Gi1/β1/γ2
13.04Single8EA0Iperoxo8EA0-M3-Iperoxo
13.04Single8EF5Fentanyl8EF5-μ-Fentanyl-Gi1/β1/γ2
13.04Single8EFLSR170188EFL-μ-SR17018-Gi1/β1/γ2
13.04Single8HDOBAY 60-65838HDO-A2B-BAY 60-6583-Gs/β1/γ2
13.04Single8HPTC5a anaphylatoxin C-terminal peptide8HPT-C5a1-C5a anaphylatoxin C-terminal peptide-Go/β1/γ2
13.04Single8IRURotigotine8IRU-D4-Rotigotine-chim(NtGi1-Gs-CtGi1)/β1/γ2
13.04Single8IYHMK68928IYH-HCA2-MK6892-Go/β1/γ2
13.04Single8JGFBAM8-228JGF-MRGPRX1-BAM8-22-chim(NtGi1-Gs-CtGq)/β1/γ2
13.04Single8JLPRalmitaront8JLP-TA1-Ralmitaront-Gs/β1/γ2
13.04Single8JT6(R)-IHCH-71798JT6-5-HT1A-(R)-IHCH-7179-Gi1/β1/γ2
13.04Single8JXXClobenpropit8JXX-H4-Clobenpropit-Gi1/β1/γ2
13.04Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/β1/γ2
13.04Single8TAOCDPPB8TAO-mGlu5; mGlu5-Quisqualate-CDPPB
13.04Single8VVFJDTic8VVF-κ-JDTic-Gi1/β1/γ2
13.04Single8WU1PubChem 1190256658WU1-CB1-PubChem 119025665-Arrestin2
13.04Single8X0BVU04244658X0B-mGlu5; mGlu5-Quisqualate-VU0424465
13.04Single8X0FVU04244658X0F-mGlu5; mGlu5-Quisqualate-VU0424465
13.04Single8X79MRE-2698X79-I2-MRE-269-Gs/β1/γ2
13.04Single8XBIS3E-LysoPS8XBI-GPR34-S3E-LysoPS
13.04Single8XJMLatanoprost8XJM-FP-alpha-Latanoprost-chim(NtGi2-Gs-CtGq)/β1/γ2
13.04Single8XZICMF-0198XZI-Apelin-CMF-019-Gi1/β1/γ2
13.04Single8ZR5Firuglipel8ZR5-GPR119-Firuglipel-Gs/β1/γ2
13.04Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/β1/γ2
13.04Single9B65KCA9B65-CB1-KCA-Gi1/β1/γ2
13.04Single9GE2ML1849GE2-GPR55-ML184-Cholesterol-chim(CtGi1-G13)/β1/γ2
13.04Single9IJDCarazolol9IJD-β3-Carazolol-chim(NtGi1-Gs)/β1/γ2
13.04Single9IZGNKP9IZG-LPA1-NKP-chim(NtGi1-Gs-CtGq)/β1/γ2
13.04Consensus5ht1_offOrthosteric Ligand5ht1b_off
13.04Consensus5ht1b_offOrthosteric Ligand5V54-5-HT1B-Methiothepin
13.04Consensus5ht_offOrthosteric Ligand5ht2_off 5ht1_off
13.04Consensusd4_on_gpOrthosteric Ligand8IRU-D4-Rotigotine-chim(NtGi1-Gs-CtGi1)/β1/γ2
13.04Consensusffa2_onOrthosteric Ligand8J22-FFA2-TUG-1375-Gi1/β1/γ2
13.04Consensusffa_onOrthosteric Ligandffa2_on ffa3_on
13.04Consensusffa_on_gpOrthosteric Ligandffa2_on_gp ffa3_on_gp
13.04Consensusgi_ffaOrthosteric Ligand8J21-FFA3-Butyric acid-Gi1/β1/γ2 8J22-FFA2-TUG-1375-Gi1/β1/γ2
13.04Consensusgi_lpaOrthosteric Ligand7TD1-LPA1-LPA-Gi1/β1/γ2 7YU3-LPA1-ONO-0740556-Gi1/β1/γ2
13.04Consensusgs_adrenergicOrthosteric Ligand7DHI-β2-Salbutamol-Gs/β1/γ2 7XJI-β3-Solabegron-Gs/β1/γ2 7JJO-β1-Isoprenaline-Gs/β1/γ2 6NI3-β2-BI167107-Gs/β1/γ2 8DCR-β1-Dobutamine-Gs/β1/γ2 7XJH-β3-Isoproterenol-Gs/β1/γ2 7DH5-β3-Mirabegron-Gs/β1/γ2
13.04Consensush4_on_gpOrthosteric Ligand8HN8-H4-Histamine-Gi1/β1/γ2 8HOC-H4-Imetit-Gi1/β1/γ2 8JXV-H4-Clozapine-Gi1/β1/γ2 8JXW-H4-VUF6884-Gi1/β1/γ2 8JXX-H4-Clobenpropit-Gi1/β1/γ2
13.04Consensuslpa_onOrthosteric Ligandlpa1_on
13.04Consensuslpa_on_gpOrthosteric Ligandlpa1_on_gp
13.04Consensusm1_on_gpOrthosteric Ligand6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/β1/γ2
13.04Consensusm3_offOrthosteric Ligand4U15-M3-Tiotropium 4U16-M3-N-Methyl-Scopolamine 5ZHP-M3-PubChem 134828589
13.04Consensusm5_offOrthosteric Ligand6OL9-M5-Tiotropium
13.04Consensusmuscarinic_offOrthosteric Ligandm2_off m3_off m4_off m5_off m1_off
13.04Consensusnpy_offOrthosteric Ligandnpy1_off npy2_off
13.04Consensusprotein_offOrthosteric Ligandchemokine_off grh_off
13.04Consensuss1p5_onOrthosteric Ligand7EW1-S1P5-Siponimod-Gi1/β1/γ2
13.04Consensuss1p5_on_gpOrthosteric Ligand7EW1-S1P5-Siponimod-Gi1/β1/γ2
13.04Consensustachykinin_offOrthosteric Ligandnk1_off
12.90Single4XT3Fractalkine4XT3-US28-Fractalkine
12.90Single7D3SSecretin7D3S-Secretin-Secretin-Gs/β1/γ2
12.90Single7VABNon-Acylated Tirzepatide7VAB-GIP-Non-Acylated Tirzepatide-chim(NtGi1-Gs)/β1/γ2
12.82Single7F16TIP397F16-PTH2-TIP39-Gs/β1/γ2
12.50Single4PXZ2MeSADP4PXZ-P2Y12-2MeSADP
12.50Single4Z36ONO-30805734Z36-LPA1-ONO-3080573
12.50Single5CXVTiotropium5CXV-M1-Tiotropium
12.50Single5TZYMK8666; PubChem 1270535975TZY-FFA1-MK8666; PubChem 127053597
12.50Single5UNHPubChem 1264564065UNH-AT2-PubChem 126456406
12.50Single6A93Risperidone6A93-5-HT2A-Risperidone
12.50Single6H7NS-Xamoterol6H7N-β1-S-Xamoterol
12.50Single6KPGAM8416KPG-CB1-AM841-Gi1/β1/γ2
12.50Single6P9XCorticoliberin6P9X-CRF1-Corticoliberin-Gs/β1/γ2
12.50Single6UVAAdrenomedullin-26UVA-CT Like (AM2)-Adrenomedullin-2-Gs/β1/γ2; RAMP3
12.50Single7AD3Alpha-factor mating pheromone7AD3-STE2-α-factor mating pheromone-Gi1/STE4/γ2
12.50Single7DFPSpiperone7DFP-D2-Spiperone
12.50Single7EO4BAF3127EO4-S1P1-BAF312-Gi1/β1/γ2
12.50Single7EPENAM5637EPE-mGlu2; mGlu2-NAM563
12.50Single7F55Bremelanotide7F55-MC4-Bremelanotide-Gs/β1/γ2
12.50Single7L1VPubChem 1554910097L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/β1/γ2
12.50Single7TYNCalcitonin-17TYN-CT-Calcitonin-1-Gs/β1/γ2
12.50Single7V68PubChem 576644067V68-M4-Iperoxo-PubChem 57664406-Gi1/β1/γ2
12.50Single7W0LPubChem 1227019087W0L-Apelin-PubChem 122701908-Gi1/β1/γ2
12.50Single7WC4Serotonin7WC4-5-HT2A-Serotonin
12.50Single7WCMMBX-29827WCM-GPR119-MBX-2982-Gs/β1/γ2
12.50Single7YITNalfurafine7YIT-κ-Nalfurafine
12.50Single7YMJTamsulosin7YMJ-Alpha1A-Tamsulosin
12.50Single8DWCProenkephalin-A8DWC-MRGPRX1-Proenkephalin-A-chim(NtGi2L-Gs-CtGq)/β1/γ2
12.50Single8F0JPramlintide Analogue San458F0J-CT-Pramlintide Analogue San45-Gs/β1/γ2
12.50Single8FYTLSD8FYT-5-HT1A-LSD-Gi1/β1/γ1
12.50Single8HQMNPGLY8HQM-GPR132-NPGLY-Gi1/β1/γ2
12.50Single8HVINOX-6-78HVI-GPR132-NOX-6-7-Gi1/β1/γ2
12.50Single8JD3HZR; PEF8JD3-mGlu2; mGlu3-Glutamate-HZR; PEF-Gi1/β1/γ2
12.50Single8WRBLysophosphatidylserine8WRB-GPR34-Lysophosphatidylserine-Gi1/β1/γ2
12.50Single8XYIVUF106618XYI-CXCR3-VUF10661
12.50Single8ZPLHF511168ZPL-CXCR4-HF51116-Cholesterol
12.50Single9MQLIsoquinuclidine9MQL-κ-Isoquinuclidine
12.50Consensus5ht1a_onOrthosteric Ligand8FYT-5-HT1A-LSD-Gi1/β1/γ1 7E2Y-5-HT1A-Serotonin-Gi1/β1/γ2 7E2Z-5-HT1A-Aripiprazole-Gi1/β1/γ2 8FYX-5-HT1A-Buspirone-Gi1/β1/γ1 8JSP-5-HT1A-Ulotaront-Gi1/β1/γ2 8JT6-5-HT1A-(R)-IHCH-7179-Gi1/β1/γ2 8FY8-5-HT1A-5-MeO-DMT-Gi1/β1/γ1 8FYE-5-HT1A-4-F,5-MeO-PyrT-Gi1/β1/γ1 8FYL-5-HT1A-Vilazodone-Gi1/β1/γ1
12.50Consensus5ht1a_on_gpOrthosteric Ligand8FYT-5-HT1A-LSD-Gi1/β1/γ1 8FYX-5-HT1A-Buspirone-Gi1/β1/γ1 8JSP-5-HT1A-Ulotaront-Gi1/β1/γ2 8JT6-5-HT1A-(R)-IHCH-7179-Gi1/β1/γ2 7E2Y-5-HT1A-Serotonin-Gi1/β1/γ2 7E2Z-5-HT1A-Aripiprazole-Gi1/β1/γ2 8FY8-5-HT1A-5-MeO-DMT-Gi1/β1/γ1 8FYE-5-HT1A-4-F,5-MeO-PyrT-Gi1/β1/γ1 8FYL-5-HT1A-Vilazodone-Gi1/β1/γ1
12.50Consensusalpha1_offOrthosteric Ligandalpha1a_off
12.50Consensusalpha1a_offOrthosteric Ligand7YMJ-Alpha1A-Tamsulosin
12.50Consensuscb1_onOrthosteric Ligand6KPG-CB1-AM841-Gi1/β1/γ2 8K8J-CB1-Fenofibrate-chim(Gs-CtGq)/β1/γ2
12.50Consensusffa2_on_gpOrthosteric Ligand8J22-FFA2-TUG-1375-Gi1/β1/γ2
12.50Consensuskop_onOrthosteric Ligand8F7W-κ-Dynorphin-Gi1/β1/γ2 8DZS-κ-GR89,696-chim(NtGi2-Gz)/β1/γ2 8DZP-κ-momSalB-Gi1/β1/γ2
12.50Consensuslipid_offonOrthosteric Ligandlipid_off lipid_on
12.50Consensuslipid_offon_gpOrthosteric Ligandlipid_on_gp lipid_off
12.50Consensusm1_offOrthosteric Ligand5CXV-M1-Tiotropium
12.50Consensuss1p3_onOrthosteric Ligand7EW3-S1P3-S1P-Gi1/β1/γ2 7EW4-S1P3-CYM5541-Gi1/β1/γ2 7EW2-S1P3-Fingolimod-Gi1/β1/γ2
12.20Single8F2BPramlintide Analogue San458F2B-CT (AMY3)-Pramlintide Analogue San45-Gs/β1/γ2; RAMP3
12.12Single6PB1Urocortin6PB1-CRF2-Urocortin-chim(NtGi1-Gs)/β1/γ2
12.12Single6UUSAdrenomedullin6UUS-CT Like (AM2)-Adrenomedullin-Gs/β1/γ2; RAMP3
12.00Single5UNGPubChem 157800525UNG-AT2-PubChem 15780052
12.00Single5X93K-87945X93-ETB-K-8794
12.00Single6BQHRitanserin6BQH-5-HT2C-Ritanserin
12.00Single6M1HMaxadilan6M1H-PAC1-Maxadilan-Gs/β1/γ2
12.00Single7U2KC6-guano7U2K-μ-C6-guano-Gi1/β1/γ2
12.00Single7X8RBOC57X8R-GLP-1-BOC5-Gs/β1/γ2
12.00Single7XK2MK68927XK2-HCA2-MK6892-Gi1/β1/γ2
12.00Single7XZ6APD6687XZ6-GPR119-APD668-Gs/β1/γ2
12.00Single8GUTLEI-1028GUT-CB2-LEI-102-Gi1/β1/γ2
12.00Single8IJDMK68928IJD-HCA2-MK6892-Gi1/β1/γ2
12.00Single8K2XCXCL108K2X-CXCR3-CXCL10-Gi1/β1/γ2
12.00Single8XJKCloprosetnol8XJK-FP-alpha-Cloprosetnol-chim(NtGi1-Gs-CtGq)/β1/γ2
12.00Consensus5ht2c_offOrthosteric Ligand6BQH-5-HT2C-Ritanserin
12.00Consensuscb1_on_gpOrthosteric Ligand6KPG-CB1-AM841-Gi1/β1/γ2 8K8J-CB1-Fenofibrate-chim(Gs-CtGq)/β1/γ2
12.00Consensusd2_offOrthosteric Ligand6CM4-D2-Risperidone 6LUQ-D2-Haloperidol 7DFP-D2-Spiperone
12.00Consensusendothelin_offOrthosteric Ligandetb_off
12.00Consensusetb_offOrthosteric Ligand5X93-ETB-K-8794 5XPR-ETB-Bosentan 6K1Q-ETB-IRL2500
12.00Consensusfp-alpha_onOrthosteric Ligand8IUK-FP-alpha-PGF2-α-chim(NtGi1-Gs-CtGq)/β1/γ2 8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/β1/γ2 8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/β1/γ2
12.00Consensusfp-alpha_on_gpOrthosteric Ligand8IUK-FP-alpha-PGF2-α-chim(NtGi1-Gs-CtGq)/β1/γ2 8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/β1/γ2 8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/β1/γ2
12.00Consensuskop_on_gpOrthosteric Ligand8F7W-κ-Dynorphin-Gi1/β1/γ2 8DZS-κ-GR89,696-chim(NtGi2-Gz)/β1/γ2 8DZP-κ-momSalB-Gi1/β1/γ2
11.76Single6OY9All-trans-Retinal6OY9-Rhodopsin-All-trans-Retinal-Gt/β1/γ1
11.76Single6XBM25(S)-Epoxycholesterol6XBM-SMO-25(S)-Epoxycholesterol-Gi1/β1/γ2
11.76Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
11.76Single7MTBAll-trans-Retinal7MTB-Rhodopsin-All-trans-Retinal-GRK1
11.76Single7VDMSubstance-P7VDM-MRGPRX2-Substance-P-Gi1/β1/γ2
11.76Single8DPHLorcaserin8DPH-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/β1/γ2
11.76Single8IWM2-Phenylethylamine8IWM-TA9-2-Phenylethylamine
11.76Single8WC5Tetramethylammonium Ion8WC5-TA1-Tetramethylammonium Ion-chim(NtGi1-Gs)/β1/γ2
11.76Single9CHUNoradrenaline9CHU-β2-Noradrenaline
11.76Consensusgs_histamineOrthosteric Ligand8POK-H2-Histamine-Gs/β1/γ2
11.76Consensush2_onOrthosteric Ligand8POK-H2-Histamine-Gs/β1/γ2
11.76Consensusopsins_onOrthosteric Ligandrhodopsin_on opsin1lw_on
11.76Consensussensory_onOrthosteric Ligandopsins_on
11.54Single7S8LCortistatin-147S8L-MRGPRX2-Cortistatin-14-chim(NtGi2L-Gs-CtGq)/β1/γ2
11.54Single7SK9CCX6627SK9-ACKR3-CCX662
11.54Single7XBXCX3CL17XBX-CX3CR1-CX3CL1-Gi1/β1/γ2
11.54Single8F7REndomorphin8F7R-μ-Endomorphin-Gi1/β1/γ2
11.54Single8IEIA1LYA8IEI-GPR156-A1LYA
11.54Single8J22TUG-13758J22-FFA2-TUG-1375-Gi1/β1/γ2
11.54Single8X5YAstemizole8X5Y-H1-Astemizole
11.11Single2J4Y11-cis-Retinal2J4Y-Rhodopsin-11-cis-Retinal
11.11Single3OE6IT1t3OE6-CXCR4-IT1t
11.11Single5UNFPubChem 157800525UNF-AT2-PubChem 15780052
11.11Single6D32Cyclopamine6D32-SMO-Cyclopamine-Cyclopamine
11.11Single6FUFAll-trans-Retinal6FUF-Rhodopsin-All-trans-Retinal-Go
11.11Single6OIKLY21196206OIK-M2-Iperoxo-LY2119620-chim(NtGi1-Go)/β1/γ2
11.11Single7EJKOxymetazoline7EJK-α2a-Oxymetazoline-Go/β1/γ2
11.11Single7MT8All-trans-Retinal7MT8-Rhodopsin-All-trans-Retinal-GRK1
11.11Single7RTBPeptide-197RTB-GLP-1-Peptide-19-Gs/β1/γ2
11.11Single7VLACCL15(27-92)7VLA-CCR1-CCL15(27-92)-Gi1/β1/γ2
11.11Single8DPILorcaserin8DPI-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/β1/γ2
11.11Single8F76Propanoic acid8F76-OR51E2-Propanoic acid-Gs/β1/γ2
11.11Single8GGEConstrained Epinephrine8GGE-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
11.11Single8GGFConstrained Epinephrine8GGF-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
11.11Single8ITFDMCHA8ITF-TA9-DMCHA-chim(NtGi1-Gs)/β1/γ2
11.11Single8IU2Retinal8IU2-Opsin1LW-Retinal-Gi1/β1/γ2
11.11Single8J21Butyric acid8J21-FFA3-Butyric acid-Gi1/β1/γ2
11.11Single8JIQPeptide-158JIQ-Glucagon-Peptide-15-Gs/β1/γ2
11.11Single8JXTHistamine8JXT-H4-Histamine-PO4-Gi1/β1/γ2
11.11Single8PKMBefiradol8PKM-5-HT1A-Befiradol-t7m-Gi1/β1/γ1
11.11Single8POKHistamine8POK-H2-Histamine-Gs/β1/γ2
11.11Single8WC9ZH86518WC9-TA1-ZH8651-chim(NtGi1-Gs-CtGq)/β1/γ2
11.11Single8WKYPG-9348WKY-MC4-PG-934
11.11Single8X9UMetenolone8X9U-ADGRD1-Metenolone-chim(NtGi1-Gs)/β1/γ2
11.11Single9C1PCa; Tryptophan; '6218; PO49C1P-CaS-Ca-Ca; Tryptophan; '6218; PO4
11.11Consensusccr1_onOrthosteric Ligand7VLA-CCR1-CCL15(27-92)-Gi1/β1/γ2
11.11Consensusccr1_on_gpOrthosteric Ligand7VLA-CCR1-CCL15(27-92)-Gi1/β1/γ2
11.11Consensusffa3_onOrthosteric Ligand8J21-FFA3-Butyric acid-Gi1/β1/γ2
11.11Consensusffa3_on_gpOrthosteric Ligand8J21-FFA3-Butyric acid-Gi1/β1/γ2
11.11Consensusgi_opsinsOrthosteric Ligand8IU2-Opsin1LW-Retinal-Gi1/β1/γ2
11.11Consensusgi_sensoryOrthosteric Ligandgi_opsins
11.11Consensush2_on_gpOrthosteric Ligand8POK-H2-Histamine-Gs/β1/γ2
11.11Consensusopsin1lw_onOrthosteric Ligand8IU2-Opsin1LW-Retinal-Gi1/β1/γ2
11.11Consensusopsin1lw_on_gpOrthosteric Ligand8IU2-Opsin1LW-Retinal-Gi1/β1/γ2
11.11Consensusopsins_on_gpOrthosteric Ligandrhodopsin_on_gp opsin1lw_on_gp
11.11Consensusrhodopsin_onOrthosteric Ligand6OYA-Rhodopsin-All-trans-Retinal-Gt/β1/γ1
11.11Consensussensory_on_gpOrthosteric Ligandopsins_on_gp
10.81Single7TYYCalcitonin-17TYY-CT (AMY2)-Calcitonin-1-Gs/β1/γ2; RAMP2
10.71Single6WHCGlu16 analog of GCG6WHC-Glucagon-Glu16 analog of GCG-Gs/β1/γ2
10.71Single8IOCGamma-MSH8IOC-MC3-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
10.71Single8KH5Lysophosphatidylserine8KH5-GPR174-Lysophosphatidylserine-Gs/β1/γ2
10.71Single8XYDPlatelet Activating Factor8XYD-PAF-Platelet Activating Factor-Gi1/β1/γ2
10.71Consensusghrelin_onOrthosteric Ligand7NA7-Ghrelin-Ghrelin-27-Gi1/β1/γ2 7F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/β1/γ2 7NA8-Ghrelin-PubChem 178024-Gi1/β1/γ2
10.71Consensusghrelin_on_gpOrthosteric Ligand7NA7-Ghrelin-Ghrelin-27-Gi1/β1/γ2 7F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/β1/γ2 7NA8-Ghrelin-PubChem 178024-Gi1/β1/γ2
10.53Single5TE520-Methanoretinal5TE5-Rhodopsin-20-Methanoretinal
10.53Single6I9K9-cis-Retinal6I9K-Rhodopsin-9-cis-Retinal
10.53Single6LI0C176LI0-GPR52-C17
10.53Single6TP4ACT-4622066TP4-OX1-ACT-462206
10.53Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
10.53Single7DFLHistamine7DFL-H1-Histamine-chim(NtGi1L-Gq)/β1/γ2
10.53Single7S8NR-Zinc-35737S8N-MRGPRX2-R-Zinc-3573-chim(NtGi2L-Gs-CtGq)/β1/γ2
10.53Single7S8OR-Zinc-35737S8O-MRGPRX2-R-Zinc-3573-Gi1/β1/γ2
10.53Single7V68Iperoxo7V68-M4-Iperoxo-PubChem 57664406-Gi1/β1/γ2
10.53Single7YFDImetit7YFD-H4-Imetit-chim(NtGi1-Gs-CtGq)/β1/γ2
10.53Single8DPFLorcaserin8DPF-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/β1/γ2
10.53Single8FX5Xanomeline8FX5-M4-Xanomeline-Xanomeline-Gi1/β1/γ2
10.53Single8HN8Histamine8HN8-H4-Histamine-Gi1/β1/γ2
10.53Single8IHIAcifran8IHI-HCA2-Acifran-Gi1/β1/γ2
10.53Single8YN2Histamine8YN2-H1-Histamine-chim(NtGi1L-Gs-CtGq)/β1/γ2
10.53Single9EPRRetinal9EPR-Rhodopsin-Retinal-Gi1/β1/γ2
10.53Single9IJEEpinephrine9IJE-β3-Epinephrine-chim(NtGi1-Gs)/β1/γ2
10.53Single9J5VCpY9J5V-LPA1-CpY-Gi1/β1/γ2
10.53Consensush1_onOrthosteric Ligand7DFL-H1-Histamine-chim(NtGi1L-Gq)/β1/γ2
10.53Consensush4_onOrthosteric Ligand8HN8-H4-Histamine-Gi1/β1/γ2 8HOC-H4-Imetit-Gi1/β1/γ2 8JXV-H4-Clozapine-Gi1/β1/γ2 8JXW-H4-VUF6884-Gi1/β1/γ2 8JXX-H4-Clobenpropit-Gi1/β1/γ2
10.34Single6W25SHU91196W25-MC4-SHU9119-Ca
10.34Consensusmc3_onOrthosteric Ligand8IOC-MC3-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
10.34Consensusmc3_on_gpOrthosteric Ligand8IOC-MC3-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
10.00Single2Z7311-cis-Retinal2Z73-Rhodopsin-11-cis-Retinal
10.00Single3AYN9-cis-Retinal3AYN-Rhodopsin-9-cis-Retinal
10.00Single3ODUIT1t3ODU-CXCR4-IT1t
10.00Single3V2WPubChem 518926453V2W-S1P1-PubChem 51892645
10.00Single5WS3EMPA5WS3-OX2-EMPA
10.00Single5ZKQABT-4915ZKQ-PAF-ABT-491
10.00Single6AKYMaraviroc6AKY-CCR5-Maraviroc
10.00Single6B73MP11046B73-κ-MP1104
10.00Single6KUYPubChem 1457046436KUY-α2a-PubChem 145704643
10.00Single6TQ6PubChem 1457142836TQ6-OX1-PubChem 145714283
10.00Single7M3ECa; Ca; Tryptophan; NPS-21437M3E-CaS-Ca; Ca; Tryptophan; NPS-2143
10.00Single7M3ECa; Ca; Tryptophan; NPS-21437M3E-CaS-Ca; Ca; Tryptophan; NPS-2143
10.00Single7T6SPubChem 247763417T6S-FPR2-ALX-PubChem 24776341-Gi1/β1/γ2
10.00Single7TUZ7-alpha,25-dihydroxycholesterol7TUZ-GPR183-7-α,25-dihydroxycholesterol-Gi1/β1/γ2
10.00Single7VDLCortistatin-147VDL-MRGPRX2-Cortistatin-14-Gi1/β1/γ2
10.00Single7WF7S1P7WF7-S1P1-S1P-Gi1/β1/γ2
10.00Single7X2CFenoldopam7X2C-D1-Fenoldopam-Fenoldopam-Gs/β1/γ2
10.00Single7XRRLemborexant7XRR-OX2-Lemborexant
10.00Single7YM8Oxymetazoline7YM8-Alpha1A-Oxymetazoline-chim(Gs-CtGq)
10.00Single8DWGML3828DWG-MRGPRX1-Proenkephalin-A-ML382-chim(NtGi2L-Gs-CtGq)/β1/γ2
10.00Single8EFOPZM218EFO-μ-PZM21-Gi1/β1/γ2
10.00Single8FYXBuspirone8FYX-5-HT1A-Buspirone-Gi1/β1/γ1
10.00Single8HMPC178HMP-GPR52-C17-Gs/β1/γ2
10.00Single8J20Valeric acid8J20-FFA3-Valeric acid-AR420626-Gi1/β1/γ2
10.00Single8JPPSuccinic acid8JPP-Succinate-Succinic acid-chim(Gs-CtGq)/β1/γ1
10.00Single8T3SButyric acid8T3S-FFA2-Butyric acid-chim(NtGi2L-Gs-CtGq)/β1/γ2
10.00Single8U8FPalmitic Acid8U8F-GPR3-Palmitic Acid-Gs/β1/γ2
10.00Single8UTDMK19038UTD-HCA2-MK1903-Gi1/β1/γ2
10.00Single8WC3SEP-3638568WC3-TA1-SEP-363856-chim(NtGi1-Gs)/β1/γ2
10.00Single9C2FCa; Ca; Tryptophan; '6218; PO49C2F-CaS-Ca-Ca; Ca; Tryptophan; '6218; PO4
10.00Consensusgq_histamineOrthosteric Ligand7DFL-H1-Histamine-chim(NtGi1L-Gq)/β1/γ2
10.00Consensush1_on_gpOrthosteric Ligand7DFL-H1-Histamine-chim(NtGi1L-Gq)/β1/γ2
10.00Consensusox1_offOrthosteric Ligand6TP6-OX1-Filorexant 6TP4-OX1-ACT-462206 6V9S-OX1-GTPL11403 6TOT-OX1-Lemborexant 6TP3-OX1-Nemorexant 6TQ6-OX1-PubChem 145714283 6TQ9-OX1-SB-408124 4ZJC-OX1-SB-674042 4ZJ8-OX1-Suvorexant 6TOD-OX1-EMPA-Na 6TOS-OX1-GSK1059865-Na 6TQ4-OX1-PubChem 16046844-Na
10.00Consensuspaf_offOrthosteric Ligand5ZKQ-PAF-ABT-491
10.00Consensuss1p1_offOrthosteric Ligand3V2W-S1P1-PubChem 51892645
10.00Consensussensory_offonOrthosteric Ligandsensory_off sensory_on
10.00Consensussensory_offon_gpOrthosteric Ligandsensory_on_gp sensory_on
9.68Single7QBIAlpha-factor mating pheromone7QBI-STE2-α-factor mating pheromone
9.68Single7TYWCalcitonin-17TYW-CT (AMY1)-Calcitonin-1-Gs/β1/γ2; RAMP1
9.68Single7VL9CCL15(26-92)7VL9-CCR1-CCL15(26-92)-Gi1/β1/γ2
9.68Single7XV3Lysophosphatidylserine7XV3-GPR174-Lysophosphatidylserine-chim(NtGi1-Gs)/β1/γ2
9.52Single1F8811-cis-Retinal1F88-Rhodopsin-11-cis-Retinal
9.52Single3V2YPubChem 518926453V2Y-S1P1-PubChem 51892645
9.52Single4MQTIperoxo4MQT-M2-Iperoxo-LY2119620
9.52Single6IQLL7458706IQL-D4-L745870
9.52Single6VI4JDTic6VI4-κ-JDTic
9.52Single6WJCMuscarinic toxin 76WJC-M1-Atropine-Muscarinic toxin 7
9.52Single6ZINSR486926ZIN-NTS1-SR48692
9.52Single7EJ8Brimonidine7EJ8-α2a-Brimonidine-Go/β1/γ2
9.52Single7UM7Methylergometrine7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/β1/γ2
9.52Single7YK6PubChem 1383196747YK6-RXFP4-PubChem 138319674-Gi2/β1/γ2
9.52Single8DPGPsilocin8DPG-5-HT2C-Psilocin-chim(NtGi2L-Gs-CtGq)/β1/γ2
9.52Single8GUQOlorinab8GUQ-CB2-Olorinab-Gi1/β1/γ2
9.52Single8GURCP55,9408GUR-CB2-CP55,940-Gi1/β1/γ2
9.52Single8JD6N-(3-chlorophenyl)pyridine-2-carboxamide8JD6-mGlu4; mGlu4-Phosphoserine-N-(3-chlorophenyl)pyridine-2-carboxamide-Gi3/β1/γ2
9.52Single8K4SDCA-3P8K4S-MRGPRX4-DCA-3P-chim(NtGi1L-Gs-CtGq)/β1/γ2
9.52Single8THKA616038THK-Alpha1A-A61603-chim(NtGi2L-Gs-CtGq)/β1/γ2
9.52Single8ZMGPimavanserin8ZMG-5-HT2A-Pimavanserin
9.52Single9CBLEpinephrine9CBL-α2a-Epinephrine-Gi1/β1/γ2
9.52Consensusnop_offOrthosteric Ligand4EA3-NOP-PubChem 10296561 5DHG-NOP-C-35 5DHH-NOP-SB-612111
9.52Consensusopsins_offOrthosteric Ligandrhodopsin_off
9.52Consensussensory_offOrthosteric Ligandopsins_off
9.38Single7QBIAlpha-factor mating pheromone7QBI-STE2-α-factor mating pheromone
9.09Single2Y01Dobutamine2Y01-β1-Dobutamine
9.09Single4EA3PubChem 102965614EA3-NOP-PubChem 10296561
9.09Single5DHGC-355DHG-NOP-C-35
9.09Single5DHHSB-6121115DHH-NOP-SB-612111
9.09Single5NDDAZ8838; Na5NDD-PAR2-AZ8838; Na
9.09Single7F83PF-051904577F83-Ghrelin-PF-05190457
9.09Single7NA8PubChem 1780247NA8-Ghrelin-PubChem 178024-Gi1/β1/γ2
9.09Single7QBCAlpha-factor mating pheromone7QBC-STE2-α-factor mating pheromone
9.09Single7S15PubChem 1346112237S15-GLP-1-PubChem 134611223
9.09Single7YK7DC5910537YK7-RXFP4-DC591053-Gi2/β1/γ2
9.09Single8DZSGR89,6968DZS-κ-GR89,696-chim(NtGi2-Gz)/β1/γ2
9.09Single8EJKTAK-8758EJK-FFA1-TAK-875-chim(NtGi1L-Gs-CtGq)/β1/γ2
9.09Single8JLJT1AM8JLJ-TA1-T1AM-chim(NtGi1-Gs)/β1/γ2
9.09Single8JXRLSD8JXR-D1-LSD
9.09Single8TH3AT118-H Nanobody8TH3-AT1-AT118-H Nanobody
9.09Single8WC7ZH86678WC7-TA1-ZH8667-chim(NtGi1-Gs)/β1/γ2
9.09Single9AVGCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVG-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs)/β1/γ2
9.09Single9D61JDTic9D61-κ-JDTic-Gi1/β1/γ2
9.09Single9IMATalquetamab9IMA-GPRC5D-Talquetamab
9.09Consensusgq_amineOrthosteric Ligandgq_muscarinic gq_histamine
8.82Single5VAIGLP-15VAI-GLP-1-GLP-1-Gs/β1/γ2
8.82Single7QBCAlpha-factor mating pheromone7QBC-STE2-α-factor mating pheromone
8.82Single8KGGLPS8KGG-P2Y10-LPS-chim(NtGi2-G13)/β1/γ2
8.70Single2Y00Dobutamine2Y00-β1-Dobutamine
8.70Single4PHUFasiglifam4PHU-FFA1-Fasiglifam
8.70Single5CGCHTL142425CGC-mGlu5-HTL14242
8.70Single5XPRBosentan5XPR-ETB-Bosentan
8.70Single6HLPNetupitant6HLP-NK1-Netupitant
8.70Single6M9TMisoprostol-FA6M9T-EP3-Misoprostol-FA
8.70Single7C4SS1P7C4S-S1P3-S1P
8.70Single7E9GJNJ-404118137E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/β1/γ2
8.70Single7SBFPZM217SBF-μ-PZM21-Gi1/β1/γ2
8.70Single8GD9Rivenprost8GD9-EP4-Rivenprost-Gs/β1/γ2
8.70Single8JGGBAM8-228JGG-MRGPRX1-BAM8-22-Gi1/β1/γ2
8.70Single8KFXLMD-0098KFX-CCR8-LMD-009-Gi1/β1/γ2
8.70Single8SZGCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-chim(NtGi1-Gq)/β1/γ2
8.70Single8T6JCDPPB8T6J-mGlu5; mGlu5-CDPPB
8.70Single8T6JCDPPB8T6J-mGlu5; mGlu5-CDPPB
8.70Single8X0CVU04244658X0C-mGlu5; mGlu5-Quisqualate-VU0424465
8.70Single9DQHEP-28259DQH-MRGPRD-EP-2825-chim(NtGi1-Gs-CtGq)/β1/γ2
8.70Single9F34FOB02-04A9F34-D3-FOB02-04A-Go1/β1/γ2
8.70Consensuscb2_onOrthosteric Ligand8GUR-CB2-CP55,940-Gi1/β1/γ2 8GUS-CB2-HU-308-Gi1/β1/γ2 8GUT-CB2-LEI-102-Gi1/β1/γ2 6KPF-CB2-PubChem 145915889-Gi1/β1/γ2 6PT0-CB2-WIN 55212-2-Gi1/β1/γ2 8GUQ-CB2-Olorinab-Gi1/β1/γ2
8.70Consensuscb2_on_gpOrthosteric Ligand8GUR-CB2-CP55,940-Gi1/β1/γ2 8GUS-CB2-HU-308-Gi1/β1/γ2 8GUT-CB2-LEI-102-Gi1/β1/γ2 6KPF-CB2-PubChem 145915889-Gi1/β1/γ2 6PT0-CB2-WIN 55212-2-Gi1/β1/γ2 8GUQ-CB2-Olorinab-Gi1/β1/γ2
8.70Consensuscyslt_offOrthosteric Ligandcyslt2_off cyslt1_off
8.70Consensuslipid_onOrthosteric Ligandcannabinoid_on ffa_on lpl_on prostanoid_on leukotriene_on
8.70Consensuslipid_on_gpOrthosteric Ligandcannabinoid_on_gp ffa_on_gp lpl_on_gp prostanoid_on_gp leukotriene_on_gp
8.70Consensuslpa1_onOrthosteric Ligand7TD1-LPA1-LPA-Gi1/β1/γ2 7YU3-LPA1-ONO-0740556-Gi1/β1/γ2
8.70Consensuslpa1_on_gpOrthosteric Ligand7TD1-LPA1-LPA-Gi1/β1/γ2 7YU3-LPA1-ONO-0740556-Gi1/β1/γ2
8.70Consensuss1p5_offOrthosteric Ligand7YXA-S1P5-ONO-5430608
8.70Consensuss1p_offOrthosteric Ligands1p1_off s1p5_off
8.57Single6PB0Urocortin6PB0-CRF1-Urocortin-chim(NtGi1-Gs)/β1/γ2
8.33Single4DJHJDTic4DJH-κ-JDTic
8.33Single5XR8AM8415XR8-CB1-AM841
8.33Single6N4BMDMB-Fubinaca6N4B-CB1-MDMB-Fubinaca-Gi1/β1/γ2
8.33Single7E2ZAripiprazole7E2Z-5-HT1A-Aripiprazole-Gi1/β1/γ2
8.33Single7EW3S1P7EW3-S1P3-S1P-Gi1/β1/γ2
8.33Single7FEECP559407FEE-CB1-CP55940-ZCZ011
8.33Single8F2APramlintide Analogue San3858F2A-CT (AMY3)-Pramlintide Analogue San385-Gs/β1/γ2; RAMP3
8.33Single8IUKPGF2-alpha8IUK-FP-alpha-PGF2-α-chim(NtGi1-Gs-CtGq)/β1/γ2
8.33Single8JD5BQI; HZE; PEF8JD5-mGlu2; mGlu4-Glutamate-BQI; HZE; PEF-Gi1/β1/γ2
8.33Single8JSRAnamorelin8JSR-Ghrelin-Anamorelin-chim(NtGi1-Gs-CtGq)/β1/γ2
8.33Single8XVLZibotentan8XVL-ETA-Zibotentan
8.33Single8YNTSNAP-948478YNT-MCH1-SNAP-94847
8.33Single9F33FOB02-04A9F33-D3-FOB02-04A-Go1/β1/γ2
8.33Single9ITELPA9ITE-LPA6-LPA-chim(NtGi2-G13)/β1/γ2
8.33Consensusgi_cannabinoidOrthosteric Ligand8GUR-CB2-CP55,940-Gi1/β1/γ2 8GUS-CB2-HU-308-Gi1/β1/γ2 8GUT-CB2-LEI-102-Gi1/β1/γ2 8GUQ-CB2-Olorinab-Gi1/β1/γ2 6KPF-CB2-PubChem 145915889-Gi1/β1/γ2 6PT0-CB2-WIN 55212-2-Gi1/β1/γ2 6KPG-CB1-AM841-Gi1/β1/γ2
8.33Consensuskop_offOrthosteric Ligand4DJH-κ-JDTic
8.33Consensusp2y12_onOrthosteric Ligand7XXI-P2Y12-2MeSADP-Gi2/β1/γ2
8.00Single4PY02MeSATP4PY0-P2Y12-2MeSATP
8.00Single6CM4Risperidone6CM4-D2-Risperidone
8.00Single6KQICP559406KQI-CB1-CP55940-Org27569
8.00Single6RZ7ONO-25703666RZ7-CysLT2-ONO-2570366
8.00Single6XOXOrforglipron6XOX-GLP-1-Orforglipron-chim(NtGi1-Gs)/β1/γ2
8.00Single6ZG4HTL00099366ZG4-M1-HTL0009936
8.00Single7JNIOlodanrigan7JNI-AT2-Olodanrigan
8.00Single7W0NElabela7W0N-Apelin-Elabela-Gi1/β1/γ2
8.00Single7XXI2MeSADP7XXI-P2Y12-2MeSADP-Gi2/β1/γ2
8.00Single8GCPPGE28GCP-EP4-PGE2-Gi1/β1/γ2
8.00Single8IQ6Latanoprost8IQ6-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/β1/γ2
8.00Single8VHFMBX-29828VHF-GPR119-MBX-2982-Gs/β1/γ2
8.00Single8XJNCloprosetnol8XJN-TP-Cloprosetnol-chim(NtGi1-Gs-CtGq)/β1/γ2
8.00Single8XQNCholesterol8XQN-TAS2R14-Cholesterol-Aristolochic acid A-Gi1/β1/γ1
8.00Single8XQSCholesterol8XQS-TAS2R14-Cholesterol-Flufenamic acid-Gi1/β1/γ1
8.00Consensuscannabinoid_onOrthosteric Ligandcb2_on cb1_on
8.00Consensuscannabinoid_on_gpOrthosteric Ligandcb2_on_gp cb1_on_gp
8.00Consensusgi_p2yOrthosteric Ligand7XXI-P2Y12-2MeSADP-Gi2/β1/γ2
8.00Consensusleukotriene_offOrthosteric Ligandblt_off cyslt_off
8.00Consensusp2y12_on_gpOrthosteric Ligand7XXI-P2Y12-2MeSADP-Gi2/β1/γ2
7.69Single5CGDHTL142425CGD-mGlu5-HTL14242
7.69Single6D32Cyclopamine6D32-SMO-Cyclopamine-Cyclopamine
7.69Single6D35Cholesterol6D35-SMO-Cholesterol
7.69Single6K1QIRL25006K1Q-ETB-IRL2500
7.69Single6N51Quisqualate6N51-mGlu5; mGlu5-Quisqualate
7.69Single6N51Quisqualate6N51-mGlu5; mGlu5-Quisqualate
7.69Single6RZ9ONO-27703726RZ9-CysLT2-ONO-2770372
7.69Single6UO8SKF975416UO8-GABAB1, GABAB2-SKF97541-GS39783
7.69Single6UO9SKF975416UO9-GABAB1, GABAB2-SKF97541
7.69Single6W2XPubChem 53110426W2X-GABAB1, GABAB2-PubChem 5311042-PubChem 23727970
7.69Single6W2YPubChem 53110426W2Y-GABAB1; GABAB1-PubChem 5311042-PubChem 23727970
7.69Single6W2YPubChem 53110426W2Y-GABAB1; GABAB1-PubChem 5311042-PubChem 23727970
7.69Single7C7QBaclofen7C7Q-GABAB1, GABAB2-Baclofen-PubChem 7023848
7.69Single7C7SCGP546267C7S-GABAB1, GABAB2-CGP54626
7.69Single7CUMCGP546267CUM-GABAB1, GABAB2-CGP54626-Phospholipid
7.69Single7D7MDinoprostone7D7M-EP4-Dinoprostone-Gs/β1/γ1
7.69Single7DD5Ca7DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
7.69Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
7.69Single7DD5Ca7DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
7.69Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
7.69Single7DGEQuisqualate7DGE-mGlu1; mGlu1-Quisqualate
7.69Single7DTTCa7DTT-CaS-Ca-Ca
7.69Single7DTTCa7DTT-CaS-Ca-Ca
7.69Single7DTUTryptophan7DTU-CaS-Tryptophan
7.69Single7DTUTryptophan7DTU-CaS-Tryptophan
7.69Single7DTVCa7DTV-CaS-Ca-Ca; Tryptophan
7.69Single7DTVCa; Tryptophan7DTV-CaS-Ca-Ca; Tryptophan
7.69Single7DTVCa7DTV-CaS-Ca-Ca; Tryptophan
7.69Single7DTVCa; Tryptophan7DTV-CaS-Ca-Ca; Tryptophan
7.69Single7E6TCa7E6T-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
7.69Single7E6TCa; Ca; Cyclomethyltryptophan; PO47E6T-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
7.69Single7E6TCa7E6T-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
7.69Single7E6TCa; Ca; Cyclomethyltryptophan; PO47E6T-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
7.69Single7E9GEglumetad7E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/β1/γ2
7.69Single7E9GEglumetad7E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/β1/γ2
7.69Single7E9HPhosphoserine7E9H-mGlu4; mGlu4-Phosphoserine-Gi3/β1/γ2
7.69Single7E9HPhosphoserine7E9H-mGlu4; mGlu4-Phosphoserine-Gi3/β1/γ2
7.69Single7EB2Baclofen7EB2-GABAB2; GABAB1-Baclofen-rac-BHFF-Gi1/β1/γ2
7.69Single7EPBEglumetad7EPB-mGlu2; mGlu2-Eglumetad
7.69Single7EPBEglumetad7EPB-mGlu2; mGlu2-Eglumetad
7.69Single7FD8Quisqualate7FD8-mGlu5; mGlu5-Quisqualate
7.69Single7FD8Quisqualate7FD8-mGlu5; mGlu5-Quisqualate
7.69Single7FD9LY3414957FD9-mGlu5; mGlu5-LY341495
7.69Single7FD9LY3414957FD9-mGlu5; mGlu5-LY341495
7.69Single7FIHhCG7FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/β1/γ2
7.69Single7FIIhCG7FII-LH-hCG-chim(NtGi1-Gs)/β1/γ2
7.69Single7M3ECa; Ca; Tryptophan; NPS-21437M3E-CaS-Ca; Ca; Tryptophan; NPS-2143
7.69Single7M3ECa; Ca; Tryptophan; NPS-21437M3E-CaS-Ca; Ca; Tryptophan; NPS-2143
7.69Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
7.69Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
7.69Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
7.69Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
7.69Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
7.69Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
7.69Single7MTQLY3414957MTQ-mGlu2; mGlu2-LY341495
7.69Single7MTQLY3414957MTQ-mGlu2; mGlu2-LY341495
7.69Single7MTRGlutamate7MTR-mGlu2; mGlu2-Glutamate-ADX55164
7.69Single7MTRGlutamate7MTR-mGlu2; mGlu2-Glutamate-ADX55164
7.69Single7MTSGlutamate7MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/β1/γ2
7.69Single7MTSGlutamate7MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/β1/γ2
7.69Single7PIUSetmelanotide7PIU-MC4-Setmelanotide-Gs/β1/γ2
7.69Single7SILCa7SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
7.69Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
7.69Single7SILCa7SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
7.69Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
7.69Single7SIMCa7SIM-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
7.69Single7SIMCa; Ca; Cyclomethyltryptophan; PO47SIM-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
7.69Single7SIMCa7SIM-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
7.69Single7SIMCa; Ca; Cyclomethyltryptophan; PO47SIM-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
7.69Single7SK7CCX6627SK7-ACKR3-CXCL12-CCX662
7.69Single7SK8CCX6627SK8-ACKR3-CXCL12-CCX662
7.69Single7T9NM22 Fab7T9N-TSH-M22 Fab-PubChem 644078-Gs/β1/γ2
7.69Single7WI6LY3414957WI6-mGlu3; mGlu3-LY341495
7.69Single7WI6LY3414957WI6-mGlu3; mGlu3-LY341495
7.69Single7WI8LY3414957WI8-mGlu3; mGlu3-LY341495
7.69Single7WI8LY3414957WI8-mGlu3; mGlu3-LY341495
7.69Single7WIHLY27941937WIH-mGlu3; mGlu3-LY2794193
7.69Single7WIHLY27941937WIH-mGlu3; mGlu3-LY2794193
7.69Single7XW6M22 Fab7XW6-TSH-M22 Fab-ML109-Gs/β1/γ2
7.69Single7XW7K1-707XW7-TSH-K1-70
7.69Single8GAGPubChem 1708384908GAG-CB1-PubChem 170838490-Gi1/β1/γ2
7.69Single8JCULY3414958JCU-mGlu2; mGlu3-LY341495
7.69Single8JCULY3414958JCU-mGlu2; mGlu3-LY341495
7.69Single8JCVLY3414958JCV-mGlu2; mGlu3-LY341495
7.69Single8JCVLY3414958JCV-mGlu2; mGlu3-LY341495
7.69Single8JCWLY3414958JCW-mGlu2; mGlu3-LY341495
7.69Single8JCWLY3414958JCW-mGlu2; mGlu3-LY341495
7.69Single8JCXLY3414958JCX-mGlu2; mGlu3-LY341495
7.69Single8JCXLY3414958JCX-mGlu2; mGlu3-LY341495
7.69Single8JCYLY3414958JCY-mGlu2; mGlu3-LY341495
7.69Single8JCYLY3414958JCY-mGlu2; mGlu3-LY341495
7.69Single8JCZLY3414958JCZ-mGlu2; mGlu3-LY341495
7.69Single8JCZLY3414958JCZ-mGlu2; mGlu3-LY341495
7.69Single8JD0Glutamate8JD0-mGlu2; mGlu3-Glutamate-NAM563
7.69Single8JD1Glutamate8JD1-mGlu2; mGlu3-Glutamate
7.69Single8JD1Glutamate8JD1-mGlu2; mGlu3-Glutamate
7.69Single8JD2Glutamate8JD2-mGlu2; mGlu3-Glutamate
7.69Single8JD2Glutamate8JD2-mGlu2; mGlu3-Glutamate
7.69Single8JD3Glutamate8JD3-mGlu2; mGlu3-Glutamate-HZR; PEF-Gi1/β1/γ2
7.69Single8JD3Glutamate8JD3-mGlu2; mGlu3-Glutamate-HZR; PEF-Gi1/β1/γ2
7.69Single8JD4Glutamate8JD4-mGlu2; mGlu4-Glutamate
7.69Single8JD4Glutamate8JD4-mGlu2; mGlu4-Glutamate
7.69Single8JD5Glutamate8JD5-mGlu2; mGlu4-Glutamate-BQI; HZE; PEF-Gi1/β1/γ2
7.69Single8JD5Glutamate8JD5-mGlu2; mGlu4-Glutamate-BQI; HZE; PEF-Gi1/β1/γ2
7.69Single8JD6Phosphoserine8JD6-mGlu4; mGlu4-Phosphoserine-N-(3-chlorophenyl)pyridine-2-carboxamide-Gi3/β1/γ2
7.69Single8JD6Phosphoserine8JD6-mGlu4; mGlu4-Phosphoserine-N-(3-chlorophenyl)pyridine-2-carboxamide-Gi3/β1/γ2
7.69Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
7.69Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
7.69Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
7.69Single8SZGCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-chim(NtGi1-Gq)/β1/γ2
7.69Single8SZGCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-chim(NtGi1-Gq)/β1/γ2
7.69Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/β1/γ2
7.69Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/β1/γ2
7.69Single8SZICa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZI-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi3/β1/γ2
7.69Single8SZICa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZI-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi3/β1/γ2
7.69Single8T7HQuisqualate8T7H-mGlu5; mGlu5-Quisqualate
7.69Single8T7HQuisqualate8T7H-mGlu5; mGlu5-Quisqualate
7.69Single8T8MQuisqualate8T8M-mGlu5; mGlu5-Quisqualate
7.69Single8T8MQuisqualate8T8M-mGlu5; mGlu5-Quisqualate
7.69Single8TAOQuisqualate8TAO-mGlu5; mGlu5-Quisqualate-CDPPB
7.69Single8TAOQuisqualate8TAO-mGlu5; mGlu5-Quisqualate-CDPPB
7.69Single8TQBCa; PAM VU60233268TQB-mGlu3; mGlu3-Ca; PAM VU6023326-Ca
7.69Single8TQBCa; PAM VU60233268TQB-mGlu3; mGlu3-Ca; PAM VU6023326-Ca
7.69Single8TR0LY3414958TR0-mGlu3; mGlu3-LY341495
7.69Single8TR0LY3414958TR0-mGlu3; mGlu3-LY341495
7.69Single8TR2Ca; LY3792688TR2-mGlu3; mGlu3-Ca; LY379268-Ca
7.69Single8TR2Ca; LY3792688TR2-mGlu3; mGlu3-Ca; LY379268-Ca
7.69Single8TRCLY3414958TRC-mGlu3; mGlu3-LY341495
7.69Single8TRCLY3414958TRC-mGlu3; mGlu3-LY341495
7.69Single8TRDLY3414958TRD-mGlu3; mGlu3-LY341495
7.69Single8TRDLY3414958TRD-mGlu3; mGlu3-LY341495
7.69Single8WG9(2S)-2-amino-4-phosphonobutanoic acid8WG9-mGlu4; mGlu2-(2S)-2-amino-4-phosphonobutanoic acid
7.69Single8WGBGlutammate8WGB-mGlu4; mGlu2-Glutammate-W9R-Gi3/β1/γ2
7.69Single8WGBGlutammate8WGB-mGlu4; mGlu2-Glutammate-W9R-Gi3/β1/γ2
7.69Single8WGCLY3792688WGC-mGlu4; mGlu2-LY379268
7.69Single8WGDWAG/WA68WGD-mGlu4; mGlu2-WAG/WA6
7.69Single8WGDWAG/WA68WGD-mGlu4; mGlu2-WAG/WA6
7.69Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
7.69Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
7.69Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/β1/γ2
7.69Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/β1/γ2
7.69Single8WRZPubChem 1023367048WRZ-CB1-PubChem 102336704-Arrestin2
7.69Single8WVXNorrin8WVX-LGR4-Norrin
7.69Single8WVYNorrin8WVY-LGR4-Norrin
7.69Single8X0BQuisqualate8X0B-mGlu5; mGlu5-Quisqualate-VU0424465
7.69Single8X0BQuisqualate8X0B-mGlu5; mGlu5-Quisqualate-VU0424465
7.69Single8X0CQuisqualate8X0C-mGlu5; mGlu5-Quisqualate-VU0424465
7.69Single8X0CQuisqualate8X0C-mGlu5; mGlu5-Quisqualate-VU0424465
7.69Single8X0DQuisqualate8X0D-mGlu5; mGlu5-Quisqualate-VU0424465
7.69Single8X0DQuisqualate8X0D-mGlu5; mGlu5-Quisqualate-VU0424465
7.69Single8X0EQuisqualate8X0E-mGlu5; mGlu5-Quisqualate
7.69Single8X0EQuisqualate8X0E-mGlu5; mGlu5-Quisqualate
7.69Single8X0FQuisqualate8X0F-mGlu5; mGlu5-Quisqualate-VU0424465
7.69Single8X0FQuisqualate8X0F-mGlu5; mGlu5-Quisqualate-VU0424465
7.69Single8X0GQuisqualate8X0G-mGlu5; mGlu5-Quisqualate
7.69Single8X0GQuisqualate8X0G-mGlu5; mGlu5-Quisqualate
7.69Single8X0HQuisqualate8X0H-mGlu5; mGlu5-Quisqualate
7.69Single8X0HQuisqualate8X0H-mGlu5; mGlu5-Quisqualate
7.69Single8XJOU466198XJO-TP-U46619-chim(NtGi1-Gs-CtGq)/β1/γ2
7.69Single8XUMR-spondin-28XUM-LGR4-R-spondin-2
7.69Single8XVJMacitentan8XVJ-ETA-Macitentan
7.69Single9ASBCa9ASB-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
7.69Single9ASBCa; Ca; Cyclomethyltryptophan; 9IG; PO49ASB-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
7.69Single9AVGCa9AVG-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs)/β1/γ2
7.69Single9AVGCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVG-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs)/β1/γ2
7.69Single9AVLCa9AVL-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi3/β2/γ2
7.69Single9AVLCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVL-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi3/β2/γ2
7.69Single9AVLCa9AVL-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi3/β2/γ2
7.69Single9AVLCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVL-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi3/β2/γ2
7.69Single9AXFCa9AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
7.69Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
7.69Single9AXFCa9AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
7.69Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
7.69Single9AYFCa9AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/β1/γ2
7.69Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/β1/γ2
7.69Single9C1PCa9C1P-CaS-Ca-Ca; Tryptophan; '6218; PO4
7.69Single9C1PCa; Tryptophan; '6218; PO49C1P-CaS-Ca-Ca; Tryptophan; '6218; PO4
7.69Single9C1PCa9C1P-CaS-Ca-Ca; Tryptophan; '6218; PO4
7.69Single9C1PCa; Tryptophan; '6218; PO49C1P-CaS-Ca-Ca; Tryptophan; '6218; PO4
7.69Single9C2FCa9C2F-CaS-Ca-Ca; Ca; Tryptophan; '6218; PO4
7.69Single9C2FCa; Ca; Tryptophan; '6218; PO49C2F-CaS-Ca-Ca; Ca; Tryptophan; '6218; PO4
7.69Single9C2FCa9C2F-CaS-Ca-Ca; Ca; Tryptophan; '6218; PO4
7.69Single9C2FCa; Ca; Tryptophan; '6218; PO49C2F-CaS-Ca-Ca; Ca; Tryptophan; '6218; PO4
7.69Single9II2Glutamate9II2-mGlu3; mGlu3-Glutamate-Arrestin2
7.69Single9II2Glutamate9II2-mGlu3; mGlu3-Glutamate-Arrestin2
7.69Single9II3Glutamate9II3-mGlu3; mGlu3-Glutamate-Arrestin2
7.69Single9II3Glutamate9II3-mGlu3; mGlu3-Glutamate-Arrestin2
7.69Consensuscyslt2_offOrthosteric Ligand6RZ7-CysLT2-ONO-2570366 6RZ8-CysLT2-ONO-2080365 6RZ9-CysLT2-ONO-2770372
7.69Consensusprostanoid_onOrthosteric Ligandtp_on fp-alpha_on
7.69Consensusprostanoid_on_gpOrthosteric Ligandtp_on_gp fp-alpha_on_gp
7.69Consensustp_onOrthosteric Ligand8XJO-TP-U46619-chim(NtGi1-Gs-CtGq)/β1/γ2
7.69Consensustp_on_gpOrthosteric Ligand8XJO-TP-U46619-chim(NtGi1-Gs-CtGq)/β1/γ2
7.41Single6RZ6ONO-25703666RZ6-CysLT2-ONO-2570366
7.41Single7AUESetmelanotide7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2
7.41Single8GDAL9026888GDA-EP4-L902688-Gs/β1/γ2
7.41Single8IQ4Carboprost8IQ4-FP-alpha-Carboprost-chim(NtGi1-Gs-CtGq)/β1/γ2
7.41Single8XQLCholesterol8XQL-TAS2R14-Cholesterol-Aristolochic acid A-Gt3/β1/γ1
7.41Single8XQOCholesterol8XQO-TAS2R14-Cholesterol-Aristolochic acid A-Gi1/β1/γ1
7.41Single9ITBLPA9ITB-LPA6-LPA-chim(NtGi1-Gs-CtGq)/β1/γ2
7.14Single6RZ8ONO-20803656RZ8-CysLT2-ONO-2080365
7.14Single6X19CHU-1286X19-GLP-1-CHU-128-Gs/β1/γ2
7.14Single7DD6Ca7DD6-CaS-Ca-Ca; Ca; Tryptophan
7.14Single7DD6Ca; Ca; Tryptophan7DD6-CaS-Ca-Ca; Ca; Tryptophan
7.14Single7DD6Ca7DD6-CaS-Ca-Ca; Ca; Tryptophan
7.14Single7DD6Ca; Ca; Tryptophan7DD6-CaS-Ca-Ca; Ca; Tryptophan
7.14Single7DD7Ca7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
7.14Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
7.14Single7DD7Ca7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
7.14Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
7.14Single7W56Neuromedin-S7W56-NMUR1-Neuromedin-S-chim(NtGi1-Gs-CtGq)/β1/γ2
7.14Single9ASBCa9ASB-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
7.14Single9ASBCa; Ca; Cyclomethyltryptophan; 9IG; PO49ASB-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
7.14Single9AVGCa9AVG-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs)/β1/γ2
7.14Single9AVGCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVG-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs)/β1/γ2
7.14Single9AYFCa9AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/β1/γ2
7.14Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/β1/γ2
6.90Single7DDZJNJ-310200287DDZ-Y2-JNJ-31020028
6.90Single7E14Orforglipron7E14-GLP-1-Orforglipron-PubChem 156022738-Gs/β1/γ2
6.90Consensusnpy2_offOrthosteric Ligand7DDZ-Y2-JNJ-31020028
6.67Single7KNUCalcitonin gene-related peptide-17KNU-CT Like-Calcitonin gene-related peptide-1-RAMP1
6.67Single7T9MCS-17 Antibody7T9M-TSH-CS-17 Antibody
6.67Single8TLMAnti-murine CCR8 antibody8TLM-CCR8-Anti-murine CCR8 antibody
6.45Single7AD3Alpha-factor mating pheromone7AD3-STE2-α-factor mating pheromone-Gi1/STE4/γ2
6.45Single7TYIAmylin7TYI-CT-Amylin-Gs/β1/γ2
6.25Single4A4MAll-trans-Retinal4A4M-Rhodopsin-All-trans-Retinal-Gt(CT)
6.25Single5EN0All-trans-Retinal5EN0-Rhodopsin-All-trans-Retinal-Gt(CT)
6.25Single6O3CCholesterol6O3C-SMO-SAG21k-Cholesterol
6.25Single7FIGhCG7FIG-LH-hCG-chim(NtGi1L-Gs)/β1/γ2
6.25Single7UTZTR14027UTZ-TSH-TR1402-PubChem 644078-Gs/β1/γ2
6.25Single7XW5TSH7XW5-TSH-TSH-ML109-Gs/β1/γ2
6.25Single7ZI0Cholesterol7ZI0-SMO-SAG-Cholesterol
6.25Single8JGBConorfamide-Tx28JGB-MRGPRX1-Conorfamide-Tx2-Gi1/β1/γ2
6.25Consensusp2y10_onOrthosteric Ligand8KGG-P2Y10-LPS-chim(NtGi2-G13)/β1/γ2
5.88Single3PXOAll-trans-Retinal3PXO-Rhodopsin-All-trans-Retinal
5.88Single5DYSAll-trans-Retinal5DYS-Rhodopsin-All-trans-Retinal
5.88Single5L7DCholesterol5L7D-SMO-Cholesterol
5.88Single7T9ITSH7T9I-TSH-TSH-Gs/β1/γ2
5.88Single7XKDBeta-Hydroxyandrosterone7XKD-ADGRG2-β-Hydroxyandrosterone-Gs/β1/γ2
5.88Single7XKEBeta-Hydroxyandrosterone7XKE-ADGRG2-β-Hydroxyandrosterone-chim(NtGi1-Gs)/β1/γ2
5.88Single8HS2Fab0468HS2-GPR20-Fab046
5.88Single8I2GGlycoprotein hormones alpha chain8I2G-FSH-Glycoprotein hormones α chain-Compound 716340-Gs/β1/γ2
5.88Consensusp2y10_on_gpOrthosteric Ligand8KGG-P2Y10-LPS-chim(NtGi2-G13)/β1/γ2
5.56Single7Y14Beta-Alanine7Y14-MRGPRD-β-Alanine
5.56Single9C2FCa; Ca; Tryptophan; '6218; PO49C2F-CaS-Ca-Ca; Ca; Tryptophan; '6218; PO4
5.26Single2ZIY11-cis-Retinal2ZIY-Rhodopsin-11-cis-Retinal
5.26Single3C9M11-cis-Retinal3C9M-Rhodopsin-11-cis-Retinal
5.26Single3PQRAll-trans-Retinal3PQR-Rhodopsin-All-trans-Retinal-Gt(CT)
5.26Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
5.26Single7F61Cholesterol7F61-H3-PF-03654746-Cholesterol
5.26Single7Y12Beta-Alanine7Y12-MRGPRD-β-Alanine-Gi1/β1/γ2
5.26Single8EITDoconexent8EIT-FFA1-Doconexent-chim(NtGi1L-Gs-CtGq)/β1/γ2
5.26Single8J6QCompound 9n8J6Q-HCA2-β-Hydroxybutyrate-Compound 9n-Gi1/β1/γ2
5.26Single8JRVGlucagon8JRV-Glucagon-Glucagon-Arrestin2
5.26Single8RQLFlufenamic acid8RQL-TAS2R14-Flufenamic acid-Flufenamic acid-chim(NtGi1-Gt3)/β1/γ2
5.26Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
5.26Single9C1PCa; Tryptophan; '6218; PO49C1P-CaS-Ca-Ca; Tryptophan; '6218; PO4
5.00Single1L9H11-cis-Retinal1L9H-Rhodopsin-11-cis-Retinal
5.00Single1U1911-cis-Retinal1U19-Rhodopsin-11-cis-Retinal
5.00Single2G87All-trans-Retinal2G87-Rhodopsin-All-trans-Retinal
5.00Single2I3511-cis-Retinal2I35-Rhodopsin-11-cis-Retinal
5.00Single3AYMAll-trans-Retinal3AYM-Rhodopsin-All-trans-Retinal
5.00Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
5.00Single7XKFBeta-Hydroxyandrosterone7XKF-ADGRG2-β-Hydroxyandrosterone-Gs/β1/γ2
5.00Single7XP6Strychnine7XP6-T2R46-Strychnine-chim(Gs-CtGt3)/β1/γ2
5.00Single8HSCFab0468HSC-GPR20-Fab046-Gi1/β1/γ2
5.00Single8J6PCompound 9n8J6P-HCA2-Niacin-Compound 9n-Gi1/β1/γ2
5.00Single8JHYCompound 9n8JHY-HCA2-Compound 9n-Gi1/β1/γ2
5.00Single8JIICompound 9n8JII-HCA2-Niacin-Compound 9n-Gi1/β1/γ2
5.00Single8JPNCis-Epoxysuccinic acid8JPN-Succinate-Cis-Epoxysuccinic acid-Gi1/β1/γ1
5.00Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
5.00Single8WP1Cis-Epoxysuccinic acid8WP1-Succinate-Cis-Epoxysuccinic acid-Gi1/β1/γ2
5.00Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/β1/γ2
5.00Single8YRGFospropofol8YRG-MRGPRX4-Fospropofol-chim(NtGi1-Gs-CtGq)/β1/γ2
4.76Single1GZM11-cis-Retinal1GZM-Rhodopsin-11-cis-Retinal
4.76Single2PED9-cis-Retinal2PED-Rhodopsin-9-cis-Retinal
4.76Single3C9L11-cis-Retinal3C9L-Rhodopsin-11-cis-Retinal
4.76Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
4.76Single7S8PMS471347S8P-MRGPRX4-MS47134-chim(NtGi2L-Gs-CtGq)/β1/γ2
4.76Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
4.76Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
4.76Single7VVOPTH7VVO-PTH1-PTH-Gs/β1/γ2
4.76Single8A6CAll-trans-Retinal8A6C-Rhodopsin-All-trans-Retinal
4.76Single8A6DAll-trans-Retinal8A6D-Rhodopsin-All-trans-Retinal
4.76Single8A6EAll-trans-Retinal8A6E-Rhodopsin-All-trans-Retinal
4.76Single8DWHPubChem 1390305318DWH-MRGPRX1-PubChem 139030531-chim(NtGi2L-Gs-CtGq)/β1/γ2
4.76Single8SZGCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-chim(NtGi1-Gq)/β1/γ2
4.76Single8U4PAMD31008U4P-CXCR4-AMD3100-Cholesterol-Gi1/β1/γ2
4.76Single8WOGSuccinic acid8WOG-Succinate-Succinic acid-Gi1/β1/γ2
4.76Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
4.76Single8YKXMaleic acid8YKX-Succinate-Maleic acid-Gi1/β1/γ1
4.76Single9AVLCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVL-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi3/β2/γ2
4.76Single9BQJRO769BQJ-μ-RO76-Gi1/β1/γ2
4.76Consensusangiotensin_offOrthosteric Ligandat1_off
4.76Consensusgi_succinateOrthosteric Ligand8YKW-Succinate-Succinic acid-Gi1/β1/γ1 8YKX-Succinate-Maleic acid-Gi1/β1/γ1
4.76Consensusrhodopsin_offOrthosteric Ligand1U19-Rhodopsin-11-cis-Retinal 2PED-Rhodopsin-9-cis-Retinal 5TE5-Rhodopsin-20-Methanoretinal
4.76Consensussuccinate_onOrthosteric Ligand8YKW-Succinate-Succinic acid-Gi1/β1/γ1 8YKX-Succinate-Maleic acid-Gi1/β1/γ1
4.76Consensussuccinate_on_gpOrthosteric Ligand8YKW-Succinate-Succinic acid-Gi1/β1/γ1 8YKX-Succinate-Maleic acid-Gi1/β1/γ1
4.55Single3OAX11-cis-Retinal3OAX-Rhodopsin-11-cis-Retinal
4.55Single4ZUDOlmesartan4ZUD-AT1-Olmesartan
4.55Single6PT0WIN 55212-26PT0-CB2-WIN 55212-2-Gi1/β1/γ2
4.55Single6ZFZ77-LH-28-16ZFZ-M1-77-LH-28-1
4.55Single6ZG9GSK10347026ZG9-M1-GSK1034702
4.55Single7ZBC11-cis-Retinal7ZBC-Rhodopsin-11-cis-Retinal
4.55Single7ZBE11-cis-Retinal7ZBE-Rhodopsin-11-cis-Retinal
4.55Single8FCZ11-cis-Retinal8FCZ-Rhodopsin-11-cis-Retinal
4.55Single8HJ5PubChem 1390305318HJ5-MRGPRX1-PubChem 139030531-chim(NtGi1-Gs-CtGq)/β1/γ2
4.55Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
4.55Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/β1/γ2
4.55Single8X7ATreprostinil8X7A-I2-Treprostinil-Gs/β1/γ2
4.55Single8YKVPubChem 1375531688YKV-Succinate-PubChem 137553168-Gi1/β1/γ2
4.55Single8ZPMAMD0708ZPM-CXCR4-AMD070-Cholesterol
4.55Single8ZPNAMD31008ZPN-CXCR4-AMD3100-Cholesterol
4.55Single9ASBCa; Ca; Cyclomethyltryptophan; 9IG; PO49ASB-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
4.55Single9AVGCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVG-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs)/β1/γ2
4.55Consensusat1_offOrthosteric Ligand4YAY-AT1-ZD-7155 4ZUD-AT1-Olmesartan
4.35Single1HZX11-cis-Retinal1HZX-Rhodopsin-11-cis-Retinal
4.35Single4YAYZD-71554YAY-AT1-ZD-7155
4.35Single5ZKPForopafant (SR27417)5ZKP-PAF-Foropafant (SR27417)
4.35Single6GPSMK08126GPS-CCR2-MK0812
4.35Single6IIVDaltroban6IIV-TP-Daltroban
4.35Single6KPFPubChem 1459158896KPF-CB2-PubChem 145915889-Gi1/β1/γ2
4.35Single6ORVTT-OAD26ORV-GLP-1-TT-OAD2-Gs/β1/γ2
4.35Single6Z10PubChem 1545855546Z10-Succinate-PubChem 154585554
4.35Single7V3ZCP559407V3Z-CB1-CP55940
4.35Single7VKTLTB47VKT-BLT1-LTB4-Gi1/β1/γ2
4.35Single7YXAONO-54306087YXA-S1P5-ONO-5430608
4.35Single8GCML9026888GCM-EP4-L902688-Gi1/β1/γ2
4.35Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/β1/γ2
4.35Single8XJLPGF2-alpha8XJL-FP-alpha-PGF2-α-chim(NtGi2-Gs-CtGq)/β1/γ2
4.35Single9IVGGLP-1 (Truncated)9IVG-GLP-1-GLP-1 (Truncated)-chim(NtGi1-Gs)/β1/γ2
4.35Consensusblt1_onOrthosteric Ligand7VKT-BLT1-LTB4-Gi1/β1/γ2
4.35Consensusblt1_on_gpOrthosteric Ligand7VKT-BLT1-LTB4-Gi1/β1/γ2
4.35Consensusblt_onOrthosteric Ligandblt1_on
4.35Consensusblt_on_gpOrthosteric Ligandblt1_on_gp
4.35Consensusccr2_offOrthosteric Ligand6GPS-CCR2-MK0812
4.35Consensusgi_leukotrieneOrthosteric Ligand7VKT-BLT1-LTB4-Gi1/β1/γ2
4.35Consensusleukotriene_onOrthosteric Ligandblt_on
4.35Consensusleukotriene_on_gpOrthosteric Ligandblt_on_gp
4.17Single5T1APubChem 68764898; PubChem 120931705T1A-CCR2-PubChem 68764898; PubChem 12093170
4.17Single5YHLPubChem 1351213525YHL-EP4-PubChem 135121352
4.17Single5YWYONO-AE3-2085YWY-EP4-ONO-AE3-208
4.17Single6GPXMK08126GPX-CCR2-MK0812
4.17Single6KPCPubChem 1459158896KPC-CB2-PubChem 145915889
4.17Single8TH4Losartan8TH4-AT1-Losartan-AT118-L Nanobody
4.17Single8YNSSNAP-948478YNS-MCH1-SNAP-94847
4.17Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/β1/γ2
4.17Single9EAHOlmesartan9EAH-AT1-Olmesartan-Nanobody AT209
4.17Consensusblt1_offOrthosteric Ligand5X33-BLT1-BIIL260 7K15-BLT1-MKD046-Na
4.17Consensusblt_offOrthosteric Ligandblt1_off
4.17Consensusep4_offOrthosteric Ligand5YWY-EP4-ONO-AE3-208 5YHL-EP4-PubChem 135121352
4.17Consensusep_offOrthosteric Ligandep4_off
4.00Single8GUSHU-3088GUS-CB2-HU-308-Gi1/β1/γ2
4.00Single8JD5BQI; HZE; PEF8JD5-mGlu2; mGlu4-Glutamate-BQI; HZE; PEF-Gi1/β1/γ2
4.00Single8XQTCholesterol8XQT-TAS2R14-Cholesterol-Cholesterol-Gi1/β1/γ1
3.85Single6AK3Dinoprostone IPGE26AK3-EP3-Dinoprostone IPGE2
3.85Single6IIURamatroban6IIU-TP-Ramatroban
3.85Single7SHEPI; PE7SHE-GPR158-PI; PE
3.85Single7T6BS1P7T6B-S1P2-S1P-chim(NtGi1L-G13)/β1/γ2
3.70Single7CX4Evatanepag7CX4-EP2-Evatanepag-Gs/β1/γ2
3.70Single7SHFPI; PE7SHF-GPR158-PI; PE-B5; RGS7
3.70Single9EAILosartan9EAI-AT1-Losartan-Nanobody AT209
3.57Single7CX2PGE27CX2-EP2-PGE2-Gs/β1/γ2
3.45Single7CX3Taprenepag7CX3-EP2-Taprenepag-Gs/β1/γ2
3.45Single8INRAlpha-MSH8INR-MC5-α-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
3.45Single8IZBLysophosphatidylserine8IZB-GPR174-Lysophosphatidylserine-Gs/β1/γ2
3.45Single8KIGSHU91198KIG-MC3-SHU9119-Ca
3.45Single8XFTR-spondin-28XFT-LGR4-R-spondin-2-ZNRF3
3.45Single8Y69R-spondin-28Y69-LGR4-R-spondin-2-Cholesterol-ZNRF3
3.33Single7SHEPI; PE7SHE-GPR158-PI; PE
3.33Single7SHFPI; PE7SHF-GPR158-PI; PE-B5; RGS7
3.33Consensusmc5_onOrthosteric Ligand8INR-MC5-α-MSH-Ca-chim(NtGi1-Gs)/β1/γ2 8IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/β1/γ2
3.23Single8WVUR-spondin-18WVU-LGR4-R-spondin-1-RNF43
3.23Single8Y69R-spondin-28Y69-LGR4-R-spondin-2-Cholesterol-ZNRF3
3.12Single8XFPR-spondin-28XFP-LGR4-R-spondin-2-ZNRF3
3.12Consensusmc5_on_gpOrthosteric Ligand8INR-MC5-α-MSH-Ca-chim(NtGi1-Gs)/β1/γ2 8IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/β1/γ2
2.86Single8XFSR-spondin-28XFS-LGR4-R-spondin-2-ZNRF3

PDB Summary
PDB 7T9N
Class A
SubFamily Protein
Type Glycoprotein Hormone
SubType TSH
Species Homo Sapiens
Ligand M22 Fab
Other Ligand(s) PubChem 644078
Protein Partners Gs/Beta1/Gamma2
PDB Resolution 2.9
Date 2022-08-03
D.O.I. 10.1038/s41586-022-05159-1
Net Summary
Imin 3.1
Number of Linked Nodes 1544
Number of Links 1980
Number of Hubs 341
Number of Links mediated by Hubs 1230
Number of Communities 45
Number of Nodes involved in Communities 520
Number of Links involved in Communities 808
Path Summary
Number Of Nodes in MetaPath 438
Number Of Links MetaPath 437
Number of Shortest Paths 234310662
Length Of Smallest Path 3
Average Path Length 128
Length of Longest Path 107
Minimum Path Strength 1.41
Average Path Strength 9.06924
Maximum Path Strength 27.8
Minimum Path Correlation 0.71
Average Path Correlation 1
Maximum Path Correlation 1
Minimum % Of Corr. Nodes 1.63934
Average % Of Corr. Nodes 128
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 75.0856
Maximum Path Hubs % 100
AnnotationTypeLinks
Gene OntologyMolecular Function
Gene OntologyBiological Process
Gene OntologyCellular Component
SCOP2Domain Identifier• L domain-like   • Transducin (heterotrimeric G protein), gamma chain
SCOP2Family Identifier• L domain-like   • Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations-• Orientations of Proteins in Membranes database (OPM)   • Protein Data Bank of Transmembrane Proteins (PDBTM)   • MemProtMD


Details about the values in these tables can be found in the corresponding documentation page .
CodeZ41
PDB ResiduesW:W:?1
Environment DetailsOpen EMBL-EBI Page
CodeZ41
Name(2S)-3-hydroxypropane-1,2-diyl dihexadecanoate
Synonyms
Identifier
FormulaC35 H68 O5
Molecular Weight568.911
SMILES
PubChem644078
Formal Charge0
Total Atoms108
Total Chiral Atoms1
Total Bonds107
Total Aromatic Bonds0

CodeNAG
PDB ResiduesH:H:?1 H:H:?2 H:H:?3
Environment DetailsOpen EMBL-EBI Page
CodeNAG
NameN-Acetylglucosamine
SynonymsN-Acetyl-D-glucosamine
Identifier
FormulaC8 H15 N O6
Molecular Weight221.208
SMILES
PubChem24139
Formal Charge0
Total Atoms30
Total Chiral Atoms5
Total Bonds30
Total Aromatic Bonds0

PDBsumOpen PDBsum Page
ChainR
ProteinReceptor
UniProtP16473
Sequence
>7T9N_Chain_R
PCECHQEED FRVTCKDIQ RIPSLPPST QTLKLIETH LRTIPSHAF 
SNLPNISRI YVSIDVTLQ QLESHSFYN LSKVTHIEI RNTRNLTYI 
DPDALKELP LLKFLGIFN TGLKMFPDL TKVYSTDIF FILEITDNP 
YMTSIPVNA FQGLCNETL TLKLYNNGF TSVQGYAFN GTKLDAVYL 
NKNKYLTVI DKDAFGGVY SGPSLLDVS QTSVTALPS KGLEHLKEL 
IARNTWTLK KLPLSLSFL HLTRADLSY PSHCCAFKM VCTPKSDEF 
NPCEDIMGY KFLRIVVWF VSLLALLGN VFVLLILLT SHYKLNVPR 
FLMCNLAFA DFCMGMYLL LIASVDLYT HSEYYNHAI DWQTGPGCN 
TAGFFTVFA SELSVYTLT VITLERWYA ITFAMRLDR KIRLRHACA 
IMVGGWVCC FLLALLPLV GISSYAKVS ICLPMDTET PLALAYIVF 
VLTLNIVAF VIVCCCYVK IYITVRNDT KIAKRMAVL IFTDFICMA 
PISFYALSA ILNKPLITV SNSKILLVL FYPLNSCAN PFLYAIFTK 
AFQRDVFIL LSKFGI


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainA
ProteinG Protein α Sub unit
UniProtP63092
Sequence
>7T9N_Chain_A
NEEKAQREA NKKIEKQLQ KDKQVYRAT HRLLLLGAD NSGKSTIVK 
QMRGIFETK FQVDKVNFH MFDVGGQRD ERRKWIQCF NDVTAIIFV 
VDSSDYNRL QEALNLFKS IWNNRWLRT ISVILFLNK QDLLAEKVL 
AGKSKLEDY FPEFARYTT PPGEDPRVT RAKYFIRDE FLRISTASG 
DGRHYCYPH FTCAVDTEN ARRIFNDCR DIIQRMHLR QYELL


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainB
ProteinG Protein β Sub unit
UniProtP62873
Sequence
>7T9N_Chain_B
ELDQLRQEA EQLKNQIRD ARKACADAT LSQITNNID PVGRIQMRT 
RRTLRGHLA KIYAMHWGT DSRLLVSAS QDGKLIIWD SYTTNKVHA 
IPLRSSWVM TCAYAPSGN YVACGGLDN ICSIYNLKT REGNVRVSR 
ELAGHTGYL SCCRFLDDN QIVTSSGDT TCALWDIET GQQTTTFTG 
HTGDVMSLS LAPDTRLFV SGACDASAK LWDVREGMC RQTFTGHES 
DINAICFFP NGNAFATGS DDATCRLFD LRADQELMT YSHDNIICG 
ITSVSFSKS GRLLLAGYD DFNCNVWDA LKADRAGVL AGHDNRVSC 
LGVTDDGMA VATGSWDSF LKIWN


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainG
ProteinG Protein γ Sub unit
UniProtP59768
Sequence
>7T9N_Chain_G
ASIAQARKL VEQLKMEAN IDRIKVSKA AADLMAYCE AHAKEDPLL 
TPVPASENP FR


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  




This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
7XW5AProteinGlycoprotein HormoneTSHHomo sapiensTSHML109Gs/β1/γ22.962022-08-2410.1038/s41586-022-05173-3
7XW5 (No Gprot) AProteinGlycoprotein HormoneTSHHomo sapiensTSHML1092.962022-08-2410.1038/s41586-022-05173-3
7XW7AProteinGlycoprotein HormoneTSHHomo sapiensK1-70--5.52022-08-1710.1038/s41586-022-05173-3
7XW6AProteinGlycoprotein HormoneTSHHomo sapiensM22 FabML109Gs/β1/γ22.782022-08-1710.1038/s41586-022-05173-3
7XW6 (No Gprot) AProteinGlycoprotein HormoneTSHHomo sapiensM22 FabML1092.782022-08-1710.1038/s41586-022-05173-3
7T9MAProteinGlycoprotein HormoneTSHHomo sapiens-CS-17 Antibody-3.12022-08-1010.1038/s41586-022-05159-1
7UTZAProteinGlycoprotein HormoneTSHHomo sapiensTR1402PubChem 644078Gs/β1/γ22.42022-08-0310.1038/s41586-022-05159-1
7UTZ (No Gprot) AProteinGlycoprotein HormoneTSHHomo sapiensTR1402PubChem 6440782.42022-08-0310.1038/s41586-022-05159-1
7T9NAProteinGlycoprotein HormoneTSHHomo sapiensM22 FabPubChem 644078Gs/β1/γ22.92022-08-0310.1038/s41586-022-05159-1
7T9N (No Gprot) AProteinGlycoprotein HormoneTSHHomo sapiensM22 FabPubChem 6440782.92022-08-0310.1038/s41586-022-05159-1
7T9IAProteinGlycoprotein HormoneTSHHomo sapiensTSH-Gs/β1/γ22.92022-08-0310.1038/s41586-022-05159-1
7T9I (No Gprot) AProteinGlycoprotein HormoneTSHHomo sapiensTSH-2.92022-08-0310.1038/s41586-022-05159-1




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