Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg Int. Strength Num Of Links Community ConSurf
1N:N:L4 4.484530
2N:N:Q6 5.8530
3N:N:P7 3.73667630
4N:N:V11 4.116530
5N:N:V19 3.805430
6N:N:I28 4.698530
7N:N:N31 6.968510
8N:N:W35 7.476530
9N:N:Y36 6.1925410
10N:N:Q37 8.046530
11N:N:Q38 8.065410
12N:N:L46 6.9925410
13N:N:Y49 11.7017610
14N:N:Y50 4.684510
15N:N:Q53 8.13410
16N:N:R61 6.72571730
17N:N:F62 6.116530
18N:N:I75 5.8430
19N:N:D82 6.646530
20N:N:A84 3.4075430
21N:N:Y86 6.84430
22N:N:Y87 6.285610
23N:N:C88 5.335430
24N:N:T89 8.78410
25N:N:W91 6.57610
26N:N:L95 4.2575430
27N:N:Q98 10.9510
28N:N:L99 3.825430
29N:N:F100 11.53410
30N:N:T104 7.6175430
31N:N:P116 4.235650
32N:N:F121 5.6075460
33N:N:P123 9.9625450
34N:N:E127 8.396560
35N:N:T134 7.21400
36N:N:L135 6.35667650
37N:N:V136 5.93167660
38N:N:L138 5.986560
39N:N:F142 8.332550
40N:N:Y143 5.97500
41N:N:W151 10.258550
42N:N:Q170 5.7445170
43N:N:Y175 7.605450
44N:N:Y180 5.85833660
45N:N:L181 7.904550
46N:N:L183 8.1875450
47N:N:W188 9.49333650
48N:N:H191 6.262550
49N:N:Y194 8.364550
50N:N:V198 4.4075450
51N:N:H200 5.75333650
52L:L:Q6 5.94833680
53L:L:L18 6.372580
54L:L:I20 5.19480
55L:L:Y27 9.35410
56L:L:R28 8.324510
57L:L:F29 8.562500
58L:L:Y32 8.42410
59L:L:N35 7.7625410
60L:L:W36 7.82580
61L:L:V37 4.8275410
62L:L:R38 11.205400
63L:L:Q39 7.695410
64L:L:L45 9.17410
65L:L:W47 7.87143710
66L:L:M48 5.466580
67L:L:R50 12.888510
68L:L:I51 3.8975400
69L:L:D52 6.664510
70L:L:T54 7.435410
71L:L:D55 6.58410
72L:L:Y57 8.41222910
73L:L:Y60 5.8825200
74L:L:I76 6.16754100
75L:L:Y80 8.60254100
76L:L:L81 8.828580
77L:L:W83 9.09680
78L:L:Y94 9.7475400
79L:L:Y95 7.17667610
80L:L:C96 7.26480
81L:L:R98 10.44510
82L:L:L99 6.1375400
83L:L:E100 6.16667610
84L:L:Y103 8.29375810
85L:L:W107 10.3429710
86L:L:S108 5.175410
87L:L:W111 8.485610
88L:L:P127 5.625490
89L:L:V129 4.3975400
90L:L:F130 5.825460
91L:L:P131 7.45400
92L:L:L132 6.392560
93L:L:P134 3.3975400
94L:L:L146 5.7185110
95L:L:L149 5.34667660
96L:L:K151 7.84333660
97L:L:D152 5.845460
98L:L:Y153 8.66667690
99L:L:P155 8.164590
100L:L:E156 8.95490
101L:L:W162 7.0885110
102L:L:F174 5.806500
103L:L:Q179 8.2125460
104L:L:Y184 11.6075490
105L:L:S187 4.828560
106L:L:V190 6.10254110
107L:L:S196 3.72754110
108L:L:L197 2.55500
109L:L:Y202 7.59254110
110L:L:H208 8.578590
111R:R:V39 4.355426
112R:R:T40 3.74408
113R:R:P48 4.6725409
114R:R:L50 4.745425
115R:R:P51 3.915425
116R:R:L57 4.396527
117R:R:K58 6.6525415
118R:R:I67 4.2875425
119R:R:F72 5.54529
120R:R:R80 12.7167614
121R:R:I81 4.7525428
122R:R:Y82 9.918514
123R:R:D86 5.9675428
124R:R:L92 4.25528
125R:R:F97 6.064529
126R:R:H105 7.775617
127R:R:E107 6.37833616
128R:R:R109 10.714515
129R:R:Y116 5.06754223
130R:R:L125 3.9225428
131R:R:L128 4.93529
132R:R:K129 8.514515
133R:R:F130 4.94429716
134R:R:F134 8.39615
135R:R:T136 5.345629
136R:R:L138 5.92428
137R:R:F141 5.43375827
138R:R:P142 4.78429729
139R:R:L144 5.2575427
140R:R:K146 4.6404
141R:R:F153 6.0425405
142R:R:F154 5.435626
143R:R:I155 4.375415
144R:R:L156 4.648527
145R:R:E157 9.712518
146R:R:I158 4.985627
147R:R:T159 7.1075415
148R:R:N161 5.11528
149R:R:M164 5.658527
150R:R:I167 4.94407
151R:R:P168 3.6225406
152R:R:F172 6.6575408
153R:R:L175 6.3625427
154R:R:K183 6.4775416
155R:R:L184 5.0075428
156R:R:Y185 8.15833617
157R:R:N187 7.01333629
158R:R:F189 8.68333628
159R:R:Y195 54144
160R:R:F197 6.19754129
161R:R:N198 9.9756147
162R:R:L202 6.1925408
163R:R:V205 4.0975407
164R:R:Y206 7.586516
165R:R:N208 9.175415
166R:R:K209 9.6625417
167R:R:N210 4.9325429
168R:R:L213 4.32429
169R:R:F221 5.353336129
170R:R:P228 4.92254128
171R:R:L231 2.8754127
172R:R:D232 11.4525419
173R:R:S234 5.0925419
174R:R:E251 7.3125415
175R:R:L252 3.1154129
176R:R:I253 7.4475414
177R:R:R255 9.76404
178R:R:R274 3.8413
179R:R:L277 3.5575409
180R:R:Y279 8.3625239
181R:R:P400 3.24754259
182R:R:F405 5.656548
183R:R:I411 5.14478
184R:R:M412 7.1825478
185R:R:R418 7.4375479
186R:R:I438 7.094188
187R:R:Y444 10.01754157
188R:R:V448 3.53509
189R:R:F451 5.4954169
190R:R:L452 4.2025409
191R:R:L456 5.8865139
192R:R:D460 7.195139
193R:R:Y466 8.82409
194R:R:D474 7.564579
195R:R:Y481 6.61833678
196R:R:Y482 7.21754248
197R:R:W488 6.16833679
198R:R:V502 4.255449
199R:R:E506 6.58408
200R:R:Y510 5.9054167
201R:R:W520 6.065407
202R:R:M542 8.5154169
203R:R:W546 7.7675409
204R:R:Y563 8.08167649
205R:R:V566 4.075449
206R:R:L570 5.702549
207R:R:P571 5.3775449
208R:R:D573 6.1875448
209R:R:Y582 5.51167649
210R:R:F594 7.82408
211R:R:Y601 7.98509
212R:R:Y605 5.0625279
213R:R:D633 6.15408
214R:R:V656 4.7125447
215R:R:V664 5.192579
216R:R:Y667 5.75857749
217R:R:N674 8.01754139
218R:R:L677 4.0354139
219R:R:Y678 5.753336139
220R:R:F685 5.826189
221R:R:R687 11.68254157
222R:R:D688 7.96254159
223R:R:I691 2.56754156
224W:W:?1 7.834711740
225H:H:?1 11.715140
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
1L:L:F64 L:L:S61 21.20453.96NoNo000
2L:L:S61 L:L:W47 21.52784.94NoYes000
3L:L:W47 N:N:Q98 13.152317.52YesYes100
4L:L:L45 N:N:F100 11.487612.18YesYes100
5L:L:L45 N:N:Y87 22.368210.55YesYes100
6N:N:G103 N:N:Y87 23.87844.35NoYes000
7N:N:G103 N:N:Q6 22.14776.58NoYes000
8L:L:L45 L:L:V37 11.15015.96YesYes100
9N:N:P7 N:N:Q6 10.64524.74YesYes300
10N:N:Q6 N:N:T104 10.592911.34YesYes300
11N:N:P7 N:N:V11 10.83783.53YesYes300
12N:N:T104 N:N:V11 10.64774.76YesYes300
13N:N:V11 N:N:V19 21.63023.21YesYes300
14N:N:L78 N:N:V19 1005.96NoYes000
15N:N:G13 N:N:L78 99.87661.71NoNo000
16N:N:G13 N:N:S12 99.81481.86NoNo000
17N:N:L109 N:N:S12 99.62924.5NoNo000
18N:N:P55 N:N:V58 80.80787.07NoNo000
19N:N:L47 N:N:V58 80.7642.98NoNo000
20N:N:F62 N:N:L47 80.3256.09YesNo000
21N:N:F62 N:N:I75 79.84988.79YesYes300
22N:N:Q53 N:N:Y49 25.411711.27YesYes100
23R:R:N208 R:R:Y185 30.35269.3YesYes157
24R:R:N208 R:R:S234 55.38465.96YesYes159
25R:R:R255 R:R:S234 55.21663.95YesYes049
26R:R:Y185 R:R:Y206 30.243913.9YesYes176
27R:R:L230 R:R:Y206 36.70718.21NoYes146
28R:R:E251 R:R:L230 36.698613.25YesNo154
29R:R:E251 R:R:R274 36.66293.49YesYes153
30N:N:L109 N:N:Y143 99.56722.34NoYes000
31N:N:P144 N:N:Y143 49.55189.74NoYes000
32N:N:H200 N:N:P144 49.29273.05YesNo500
33N:N:H200 N:N:P116 49.09037.63YesYes500
34N:N:I139 N:N:P116 88.37723.39NoYes500
35N:N:Y143 N:N:Y175 49.64293.97YesYes000
36N:N:F142 N:N:Y175 49.215911.35YesYes500
37N:N:F142 N:N:P116 49.10457.22YesYes500
38N:N:A177 N:N:I139 88.85793.25NoNo000
39N:N:A177 N:N:T165 88.68661.68NoNo000
40N:N:S178 N:N:T165 46.19036.4NoNo000
41N:N:S178 N:N:Y180 42.2226.36NoYes000
42L:L:V177 N:N:T165 42.32583.17NoNo000
43L:L:V177 N:N:Y180 42.14795.05NoYes000
44L:L:L149 N:N:Y180 40.16263.52YesYes600
45N:N:T134 N:N:Y180 39.79573.75YesYes000
46N:N:E127 N:N:T134 35.00999.88YesYes000
47L:L:L149 N:N:E127 35.12033.98YesYes600
48N:N:E127 N:N:S124 67.18884.31YesNo600
49L:L:P131 N:N:S124 66.4793.56YesNo000
50L:L:F64 L:L:M48 15.91396.22NoYes000
51L:L:K217 L:L:P131 36.23198.36NoYes000
52L:L:K217 L:L:V129 35.49354.55NoYes000
53L:L:V129 L:L:V206 32.57756.41YesNo000
54L:L:V150 L:L:V206 29.62024.81NoNo000
55L:L:V150 L:L:Y153 27.39966.31NoYes900
56L:L:P127 L:L:Y153 10.36995.56YesYes900
57L:L:P131 L:L:V219 27.36675.3YesNo000
58L:L:L146 L:L:V219 26.62777.45YesNo000
59L:L:L146 L:L:P134 12.60746.57YesYes000
60L:L:L197 L:L:P134 10.38343.28YesYes000
61R:R:R274 R:R:T399 36.66565.17YesNo034
62R:R:P400 R:R:T399 91.50283.5YesNo094
63R:R:C398 R:R:P400 91.17953.77NoYes2599
64R:R:C398 R:R:L277 91.09813.17NoYes099
65R:R:L252 R:R:L277 45.11292.77YesYes099
66R:R:L231 R:R:L252 42.12982.77YesYes1279
67R:R:L231 R:R:V205 41.00522.98YesYes077
68R:R:L182 R:R:V205 25.15024.47NoYes067
69R:R:L180 R:R:L182 11.14066.92NoNo076
70R:R:F154 R:R:L180 11.00964.87YesNo067
71R:R:F154 R:R:L128 10.11446.09YesYes269
72R:R:D276 R:R:R255 55.008221.44NoYes044
73R:R:D276 R:R:T399 54.938815.9NoNo044
74R:R:L207 R:R:V205 15.22282.98NoYes077
75R:R:L184 R:R:L207 12.05095.54YesNo087
76R:R:F172 R:R:L182 13.90618.53YesNo086
77R:R:F141 R:R:F172 10.80349.65YesYes078
78R:R:I117 R:R:P142 13.68053.39NoYes289
79R:R:I117 R:R:L92 13.44094.28NoYes288
80R:R:I67 R:R:P68 12.45013.39YesNo055
81R:R:E93 R:R:P68 12.07374.72NoNo065
82R:R:H282 R:R:L277 52.0345.14NoYes099
83R:R:H282 R:R:Y279 51.65817.62NoYes099
84R:R:I486 R:R:Y279 51.055712.09NoYes089
85R:R:I486 R:R:S281 50.57283.1NoNo089
86R:R:A485 R:R:S281 50.4523.42NoNo099
87R:R:A485 R:R:Y481 50.33115.34NoYes098
88R:R:Q489 R:R:Y481 43.00859.02NoYes098
89R:R:N406 R:R:Q489 42.88477.92NoNo099
90R:R:D403 R:R:N406 42.76116.73NoNo089
91R:R:D403 R:R:F405 42.63779.55NoYes088
92R:R:F405 W:W:?1 40.11466.11YesYes480
93R:R:Y667 W:W:?1 21.8789.25YesYes490
94R:R:M463 R:R:Y667 21.14597.18NoYes099
95R:R:M463 R:R:S671 21.01666.13NoNo099
96R:R:D460 R:R:S671 20.62844.42YesNo099
97R:R:D460 R:R:N674 15.06188.08YesYes1399
98R:R:N674 R:R:Y678 11.04673.49YesYes1399
99R:R:S505 W:W:?1 12.33163.23NoYes490
100R:R:E506 R:R:S505 12.27385.75YesNo089
101R:R:C549 R:R:E506 11.6293.04NoYes088
102R:R:C549 R:R:L507 11.49873.17NoNo089
103R:R:L507 R:R:W546 11.241511.39NoYes099
104R:R:N455 R:R:W546 10.59835.65NoYes089
105N:N:I75 N:N:V19 79.31773.07YesYes300
106N:N:P55 N:N:Y49 77.13738.34NoYes100
107N:N:Y49 R:R:Y185 50.44078.94YesYes107
108N:N:Q53 R:R:N208 25.31555.28YesYes105
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


2D representation of the interactions of this orthosteric/allosteric ligand.


Links and nodes colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
N:N:N30 R:R:N110 4.09 1 No No 0 6 0 1
N:N:N31 R:R:R109 9.64 1 Yes Yes 0 5 0 1
N:N:Y49 R:R:Y185 8.94 1 Yes Yes 0 7 0 1
N:N:Y50 R:R:F134 3.09 1 Yes Yes 0 5 0 1
N:N:Y50 R:R:E157 5.61 1 Yes Yes 0 8 0 1
N:N:D51 R:R:K209 4.15 0 No Yes 0 7 0 1
N:N:Q53 R:R:N208 5.28 1 Yes Yes 0 5 0 1
N:N:Q53 R:R:K209 10.85 1 Yes Yes 0 7 0 1
N:N:Q53 R:R:Q235 5.12 1 Yes No 0 4 0 1
N:N:L54 R:R:R255 12.15 0 No Yes 0 4 0 1
N:N:S56 R:R:E251 4.31 1 No Yes 0 5 0 1
N:N:S56 R:R:I253 3.1 1 No Yes 0 4 0 1
N:N:S56 R:R:R274 3.95 1 No Yes 0 3 0 1
N:N:D93 R:R:I85 7 1 No No 0 6 0 1
L:L:R28 R:R:K129 9.9 1 Yes Yes 0 5 0 1
L:L:R28 R:R:D151 5.96 1 Yes No 0 4 0 1
L:L:R28 R:R:F153 7.48 1 Yes Yes 0 5 0 1
L:L:S31 R:R:K129 4.59 1 No Yes 0 5 0 1
L:L:Y32 R:R:I155 3.63 1 Yes Yes 0 5 0 1
L:L:D52 R:R:R80 9.53 1 Yes Yes 0 4 0 1
L:L:D52 R:R:H105 6.3 1 Yes Yes 0 7 0 1
L:L:T54 R:R:K129 9.01 1 Yes Yes 0 5 0 1
L:L:D55 R:R:R80 13.1 1 Yes Yes 0 4 0 1
L:L:Y57 R:R:D36 5.75 1 Yes No 0 3 0 1
L:L:Y57 R:R:R38 21.61 1 Yes No 0 4 0 1
L:L:Y57 R:R:T56 7.49 1 Yes No 0 5 0 1
L:L:Y57 R:R:K58 3.58 1 Yes Yes 0 5 0 1
L:L:Y57 R:R:R80 13.38 1 Yes Yes 0 4 0 1
L:L:T58 R:R:E35 8.47 20 No No 0 1 0 1
L:L:Y60 R:R:E35 3.37 20 Yes No 0 1 0 1
L:L:K65 R:R:E34 12.15 0 No No 0 4 0 1
L:L:E100 R:R:K183 4.05 1 Yes Yes 0 6 0 1
L:L:P101 R:R:F130 8.67 1 No Yes 0 6 0 1
L:L:P101 R:R:I155 5.08 1 No Yes 0 5 0 1
L:L:G102 R:R:E107 4.91 1 No Yes 0 6 0 1
L:L:G102 R:R:F130 3.01 1 No Yes 0 6 0 1
L:L:Y103 R:R:K58 9.55 1 Yes Yes 0 5 0 1
L:L:Y103 R:R:Y82 14.89 1 Yes Yes 0 4 0 1
L:L:Y103 R:R:E107 3.37 1 Yes Yes 0 6 0 1
L:L:S104 R:R:R109 13.18 1 No Yes 0 5 0 1
L:L:W107 R:R:Y185 5.79 1 Yes Yes 0 7 0 1
R:R:D36 R:R:R38 15.48 1 No No 3 4 1 1
R:R:D36 R:R:Q55 3.92 1 No No 3 4 1 2
R:R:K58 R:R:T40 7.51 1 Yes Yes 5 8 1 2
R:R:R80 R:R:T56 9.06 1 Yes No 4 5 1 1
R:R:K58 R:R:Y82 5.97 1 Yes Yes 5 4 1 1
R:R:R80 R:R:Y82 15.43 1 Yes Yes 4 4 1 1
R:R:H105 R:R:R80 15.8 1 Yes Yes 7 4 1 1
R:R:H105 R:R:Y82 5.44 1 Yes Yes 7 4 1 1
R:R:E107 R:R:Y82 7.86 1 Yes Yes 6 4 1 1
R:R:I85 R:R:S84 7.74 0 No No 6 7 1 2
R:R:H105 R:R:T104 8.21 1 Yes No 7 5 1 2
R:R:H105 R:R:K129 5.24 1 Yes Yes 7 5 1 1
R:R:F130 R:R:H105 5.66 1 Yes Yes 6 7 1 1
R:R:E107 R:R:R109 8.14 1 Yes Yes 6 5 1 1
R:R:E107 R:R:F130 5.83 1 Yes Yes 6 6 1 1
R:R:E107 R:R:F134 8.16 1 Yes Yes 6 5 1 1
R:R:N110 R:R:R109 10.85 0 No Yes 6 5 1 1
R:R:F134 R:R:R109 11.76 1 Yes Yes 5 5 1 1
R:R:N110 R:R:N135 8.17 0 No No 6 8 1 2
R:R:D151 R:R:K129 13.83 1 No Yes 4 5 1 1
R:R:F130 R:R:G132 3.01 1 Yes No 6 5 1 2
R:R:F130 R:R:I155 3.77 1 Yes Yes 6 5 1 1
R:R:E157 R:R:F130 4.66 1 Yes Yes 8 6 1 1
R:R:F134 R:R:G132 4.52 1 Yes No 5 5 1 2
R:R:E157 R:R:F134 16.32 1 Yes Yes 8 5 1 1
R:R:F134 R:R:T159 6.49 1 Yes Yes 5 5 1 2
R:R:F153 R:R:I155 5.02 0 Yes Yes 5 5 1 1
R:R:F153 R:R:T179 3.89 0 Yes No 5 5 1 2
R:R:F153 R:R:T181 7.78 0 Yes No 5 7 1 2
R:R:E157 R:R:T159 8.47 1 Yes Yes 8 5 1 2
R:R:E157 R:R:K183 13.5 1 Yes Yes 8 6 1 1
R:R:T159 R:R:Y185 6.24 1 Yes Yes 5 7 2 1
R:R:K183 R:R:Y185 4.78 1 Yes Yes 6 7 1 1
R:R:K183 R:R:Y206 3.58 1 Yes Yes 6 6 1 2
R:R:Y185 R:R:Y206 13.9 1 Yes Yes 7 6 1 2
R:R:N208 R:R:Y185 9.3 1 Yes Yes 5 7 1 1
R:R:K209 R:R:N186 19.58 1 Yes No 7 7 1 2
R:R:L230 R:R:Y206 8.21 1 No Yes 4 6 2 2
R:R:D232 R:R:Y206 6.9 1 Yes Yes 9 6 2 2
R:R:D232 R:R:N208 16.16 1 Yes Yes 9 5 2 1
R:R:N208 R:R:S234 5.96 1 Yes Yes 5 9 1 2
R:R:K209 R:R:Q235 4.07 1 Yes No 7 4 1 1
R:R:E251 R:R:L230 13.25 1 Yes No 5 4 1 2
R:R:D232 R:R:S234 7.36 1 Yes Yes 9 9 2 2
R:R:D232 R:R:I253 15.39 1 Yes Yes 9 4 2 1
R:R:I253 R:R:S234 3.1 1 Yes Yes 4 9 1 2
R:R:R255 R:R:S234 3.95 0 Yes Yes 4 9 1 2
R:R:E251 R:R:I253 8.2 1 Yes Yes 5 4 1 1
R:R:E251 R:R:R274 3.49 1 Yes Yes 5 3 1 1
R:R:D276 R:R:R255 21.44 0 No Yes 4 4 2 1
R:R:R274 R:R:T399 5.17 1 Yes No 3 4 1 2
R:R:D276 R:R:T399 15.9 0 No No 4 4 2 2
R:R:E61 R:R:I85 2.73 0 No No 5 6 2 1
R:R:R274 R:R:T273 2.59 1 Yes No 3 4 1 2
N:N:G57 R:R:R255 1.5 0 No Yes 0 4 0 1
R:R:D151 R:R:I152 1.4 1 No No 4 3 1 2

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

2D representation of the interactions of this orthosteric/allosteric ligand.


Links and nodes colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:D403 R:R:F405 9.55 0 No Yes 8 8 2 1
R:R:F405 R:R:K565 4.96 4 Yes No 8 7 1 2
R:R:F405 R:R:V566 3.93 4 Yes Yes 8 9 1 2
R:R:F405 R:R:M572 3.73 4 Yes No 8 9 1 1
R:R:F405 W:W:?1 6.11 4 Yes Yes 8 0 1 0
R:R:P407 R:R:V656 7.07 4 No Yes 9 7 2 1
R:R:M463 R:R:Y667 7.18 0 No Yes 9 9 2 1
R:R:L570 R:R:T501 4.42 4 Yes No 9 9 1 2
R:R:T501 R:R:Y667 4.99 4 No Yes 9 9 2 1
R:R:V502 R:R:Y563 6.31 4 Yes Yes 9 9 2 2
R:R:P571 R:R:V502 3.53 4 Yes Yes 9 9 1 2
R:R:E506 R:R:S505 5.75 0 Yes No 8 9 2 1
R:R:S505 R:R:Y667 6.36 4 No Yes 9 9 1 1
R:R:S505 W:W:?1 3.23 4 No Yes 9 0 1 0
R:R:P571 R:R:Y563 8.34 4 Yes Yes 9 9 1 2
R:R:I568 R:R:V566 3.07 0 No Yes 9 9 2 2
R:R:M572 R:R:V566 6.09 4 No Yes 9 9 1 2
R:R:V566 R:R:V656 3.21 4 Yes Yes 9 7 2 1
R:R:I568 R:R:L570 5.71 0 No Yes 9 9 2 1
R:R:L570 R:R:P571 4.93 4 Yes Yes 9 9 1 1
R:R:L570 R:R:Y667 3.52 4 Yes Yes 9 9 1 1
R:R:L570 W:W:?1 9.93 4 Yes Yes 9 0 1 0
R:R:P571 W:W:?1 4.71 4 Yes Yes 9 0 1 0
R:R:M572 W:W:?1 15.21 4 No Yes 9 0 1 0
R:R:T574 W:W:?1 12.68 0 No Yes 6 0 1 0
R:R:A644 R:R:L587 3.15 4 No No 9 8 1 1
R:R:L587 R:R:L645 5.54 4 No No 8 7 1 2
R:R:L587 W:W:?1 2.98 4 No Yes 8 0 1 0
R:R:I640 R:R:P639 3.39 4 No No 9 9 1 2
R:R:I640 R:R:Y667 4.84 4 No Yes 9 9 1 1
R:R:I640 W:W:?1 14.33 4 No Yes 9 0 1 0
R:R:I654 R:R:Y643 12.09 0 No No 9 8 1 2
R:R:L662 R:R:Y643 5.86 0 No No 8 8 1 2
R:R:A644 W:W:?1 6.78 4 No Yes 9 0 1 0
R:R:A647 R:R:P652 3.74 4 No No 9 9 1 1
R:R:A647 W:W:?1 6.78 4 No Yes 9 0 1 0
R:R:P652 W:W:?1 5.89 4 No Yes 9 0 1 0
R:R:I654 R:R:N658 4.25 0 No No 9 8 1 2
R:R:I654 W:W:?1 10.23 0 No Yes 9 0 1 0
R:R:S659 R:R:V656 3.23 4 No Yes 9 7 1 1
R:R:V656 W:W:?1 5.34 4 Yes Yes 7 0 1 0
R:R:S659 W:W:?1 11.84 4 No Yes 9 0 1 0
R:R:F666 R:R:L662 3.65 0 No No 8 8 2 1
R:R:L662 W:W:?1 6.95 0 No Yes 8 0 1 0
R:R:P668 R:R:Y667 4.17 0 No Yes 9 9 2 1
R:R:Y667 W:W:?1 9.25 4 Yes Yes 9 0 1 0
R:R:L580 R:R:T574 2.95 0 No No 4 6 2 1
R:R:E404 W:W:?1 0.95 0 No Yes 7 0 1 0

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB 7T9N_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.
Net Summary
Imin 2.98
Number of Linked Nodes 953
Number of Links 1243
Number of Hubs 225
Number of Links mediated by Hubs 791
Number of Communities 27
Number of Nodes involved in Communities 343
Number of Links involved in Communities 533
Path Summary
Number Of Nodes in MetaPath 109
Number Of Links MetaPath 108
Number of Shortest Paths 5199638
Length Of Smallest Path 3
Average Path Length 40.5507
Length of Longest Path 74
Minimum Path Strength 1.355
Average Path Strength 5.9895
Maximum Path Strength 24.87
Minimum Path Correlation 0.7
Average Path Correlation 0.995529
Maximum Path Correlation 1
Minimum % Of Corr. Nodes 2.94118
Average % Of Corr. Nodes 36.1552
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 52.1818
Maximum Path Hubs % 100
AnnotationTypeLinks
Gene OntologyMolecular Function
Gene OntologyBiological Process
Gene OntologyCellular Component
SCOP2Domain Identifier• L domain-like   • Transducin (heterotrimeric G protein), gamma chain
SCOP2Family Identifier• L domain-like   • Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations-• Orientations of Proteins in Membranes database (OPM)   • Protein Data Bank of Transmembrane Proteins (PDBTM)   • MemProtMD


Details about the values in these tables can be found in the corresponding documentation page .
CodeZ41
PDB ResiduesW:W:?1
Environment DetailsOpen EMBL-EBI Page
CodeZ41
Name(2S)-3-hydroxypropane-1,2-diyl dihexadecanoate
Synonyms
Identifier
FormulaC35 H68 O5
Molecular Weight568.911
SMILES
PubChem644078
Formal Charge0
Total Atoms108
Total Chiral Atoms1
Total Bonds107
Total Aromatic Bonds0

CodeNAG
PDB ResiduesH:H:?1 H:H:?2 H:H:?3
Environment DetailsOpen EMBL-EBI Page
CodeNAG
NameN-Acetylglucosamine
SynonymsN-Acetylglucosamine
Identifier
FormulaC8 H15 N O6
Molecular Weight221.208
SMILES
PubChem24139
Formal Charge0
Total Atoms30
Total Chiral Atoms5
Total Bonds30
Total Aromatic Bonds0



This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
7XW6AProteinGlycoprotein HormoneTSHHomo sapiensM22 FabML109Gs/β1/γ22.782022-08-17doi.org/10.1038/s41586-022-05173-3
7XW6 (No Gprot) AProteinGlycoprotein HormoneTSHHomo sapiensM22 FabML1092.782022-08-17doi.org/10.1038/s41586-022-05173-3
7XW5AProteinGlycoprotein HormoneTSHHomo sapiensTSHML109Gs/β1/γ22.962022-08-24doi.org/10.1038/s41586-022-05173-3
7XW5 (No Gprot) AProteinGlycoprotein HormoneTSHHomo sapiensTSHML1092.962022-08-24doi.org/10.1038/s41586-022-05173-3
7T9NAProteinGlycoprotein HormoneTSHHomo sapiensM22 FabDPPCGs/β1/γ22.92022-08-03doi.org/10.1038/s41586-022-05159-1
7T9N (No Gprot) AProteinGlycoprotein HormoneTSHHomo sapiensM22 FabDPPC2.92022-08-03doi.org/10.1038/s41586-022-05159-1
7UTZAProteinGlycoprotein HormoneTSHHomo sapiensTR1402DPPCGs/β1/γ22.42022-08-03doi.org/10.1038/s41586-022-05159-1
7UTZ (No Gprot) AProteinGlycoprotein HormoneTSHHomo sapiensTR1402DPPC2.42022-08-03doi.org/10.1038/s41586-022-05159-1
7T9MAProteinGlycoprotein HormoneTSHHomo sapiens-CS-17 Antibody-3.12022-08-10doi.org/10.1038/s41586-022-05159-1
7T9IAProteinGlycoprotein HormoneTSHHomo sapiensTSH-Gs/β1/γ22.92022-08-03doi.org/10.1038/s41586-022-05159-1
7T9I (No Gprot) AProteinGlycoprotein HormoneTSHHomo sapiensTSH-2.92022-08-03doi.org/10.1038/s41586-022-05159-1
7XW7AProteinGlycoprotein HormoneTSHHomo sapiensK1-70--5.52022-08-17doi.org/10.1038/s41586-022-05173-3




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