psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:C31	R:R:V39	3.42	No	Yes	6	8	6
2	R:R:C31	R:R:C41	7.28	No	No	0	8	9
3	R:R:C31	R:R:L50	3.17	No	Yes	6	8	5
4	R:R:H32	R:R:Q33	3.71	No	No	0	5	5
5	R:R:Q33	R:R:T40	7.09	No	No	0	5	8
6	R:R:E35	R:R:R38	4.65	No	No	0	1	4
7	R:R:F37	R:R:S53	5.28	No	No	0	1	5
8	R:R:F37	R:R:Q55	11.71	No	No	0	1	4
9	R:R:R38	R:R:T56	6.47	No	No	0	4	5
10	L:L:E118	R:R:R38	10.47	No	No	0	5	4
11	R:R:L50	R:R:V39	7.45	Yes	Yes	6	5	6
12	R:R:T54	R:R:V39	6.35	No	Yes	0	7	6
13	R:R:L57	R:R:V39	2.98	Yes	Yes	6	7	6
14	R:R:K58	R:R:T40	6.01	No	No	0	5	8
15	R:R:C41	R:R:I44	3.27	No	No	0	9	5
16	R:R:C41	R:R:L59	3.17	No	No	0	9	6
17	L:L:Y124	R:R:K42	4.78	No	No	0	4	2
18	R:R:D43	R:R:H63	6.3	No	No	0	4	4
19	R:R:I44	R:R:T62	4.56	No	No	16	5	7
20	R:R:I44	R:R:L64	5.71	No	No	16	5	6
21	R:R:I47	R:R:P48	3.39	No	No	0	4	9
22	R:R:I47	R:R:L64	5.71	No	No	0	4	6
23	R:R:I47	R:R:I67	5.89	No	Yes	0	4	5
24	R:R:L50	R:R:P48	3.28	Yes	No	0	5	9
25	R:R:L50	R:R:P51	4.93	Yes	Yes	0	5	5
26	R:R:L50	R:R:L57	4.15	Yes	Yes	6	5	7
27	R:R:L50	R:R:L75	4.15	Yes	No	0	5	6
28	R:R:P51	R:R:T54	5.25	Yes	No	0	5	7
29	R:R:R80	R:R:T56	7.76	No	No	0	4	5
30	R:R:F72	R:R:L57	3.65	Yes	Yes	6	9	7
31	R:R:I78	R:R:L57	4.28	Yes	Yes	6	7	7
32	R:R:I60	R:R:K58	4.36	Yes	No	0	4	5
33	R:R:K58	R:R:Y82	9.55	No	Yes	0	5	4
34	R:R:I60	R:R:S84	3.1	Yes	No	17	4	7
35	L:L:I120	R:R:I60	8.83	Yes	Yes	17	3	4
36	N:N:R66	R:R:E61	3.49	No	No	0	6	5
37	R:R:L64	R:R:T62	11.79	No	No	16	6	7
38	R:R:D86	R:R:T62	14.45	No	No	0	8	7
39	R:R:Q90	R:R:R65	10.51	No	No	0	4	4
40	R:R:Q91	R:R:T66	9.92	Yes	No	5	3	5
41	R:R:E93	R:R:T66	14.11	No	No	5	6	5
42	R:R:I67	R:R:P68	3.39	Yes	No	6	5	5
43	R:R:A71	R:R:I67	3.25	No	Yes	6	8	5
44	R:R:F72	R:R:I67	5.02	Yes	Yes	6	9	5
45	R:R:I67	R:R:L92	4.28	Yes	No	0	5	8
46	R:R:I67	R:R:S96	3.1	Yes	No	0	5	7
47	R:R:A71	R:R:P68	3.74	No	No	6	8	5
48	R:R:H70	R:R:S69	4.18	Yes	No	0	4	4
49	R:R:H70	R:R:H95	7.17	Yes	Yes	5	4	5
50	R:R:H70	R:R:Y98	4.36	Yes	Yes	5	4	2
51	R:R:F72	R:R:I78	3.77	Yes	Yes	6	9	7
52	R:R:F72	R:R:I81	6.28	Yes	Yes	6	9	8
53	R:R:F72	R:R:F97	5.36	Yes	Yes	6	9	9
54	R:R:F72	R:R:L100	3.65	Yes	Yes	6	9	8
55	R:R:I78	R:R:L75	4.28	Yes	No	0	7	6
56	H:H:?4	R:R:N77	25.87	No	No	0	0	8
57	R:R:I78	R:R:I81	5.89	Yes	Yes	6	7	8
58	R:R:S79	R:R:T104	6.4	No	No	0	7	5
59	R:R:R80	R:R:Y82	8.23	No	Yes	1	4	4
60	R:R:H105	R:R:R80	3.39	Yes	No	1	7	4
61	R:R:F97	R:R:I81	3.77	Yes	Yes	6	9	8
62	R:R:I106	R:R:I81	4.42	No	Yes	6	7	8
63	R:R:H105	R:R:Y82	13.07	Yes	Yes	1	7	4
64	R:R:E107	R:R:Y82	10.1	No	Yes	1	6	4
65	R:R:I108	R:R:V83	7.68	No	No	0	8	6
66	L:L:I120	R:R:S84	4.64	Yes	No	17	3	7
67	R:R:I85	R:R:N110	4.25	Yes	Yes	0	6	6
68	N:N:S67	R:R:I85	3.1	No	Yes	0	7	6
69	N:N:T70	R:R:I85	4.56	No	Yes	0	9	6
70	L:L:I120	R:R:I85	2.94	Yes	Yes	0	3	6
71	N:N:T70	R:R:V87	3.17	No	No	0	9	4
72	R:R:E93	R:R:Q91	10.19	No	Yes	5	6	3
73	R:R:I117	R:R:L92	8.56	No	No	0	8	8
74	R:R:H95	R:R:S94	6.97	Yes	No	5	5	4
75	R:R:D118	R:R:S94	10.31	Yes	No	5	5	4
76	R:R:D120	R:R:S94	2.94	No	No	5	5	4
77	R:R:H95	R:R:Y98	13.07	Yes	Yes	5	5	2
78	R:R:H95	R:R:K123	5.24	Yes	No	5	5	4
79	R:R:F97	R:R:S96	5.28	Yes	No	0	9	7
80	R:R:F97	R:R:L100	3.65	Yes	Yes	6	9	8
81	R:R:F97	R:R:I106	5.02	Yes	No	6	9	7
82	R:R:F97	R:R:L122	8.53	Yes	No	0	9	7
83	R:R:N99	R:R:Y98	8.14	No	Yes	5	5	2
84	R:R:K123	R:R:Y98	7.17	No	Yes	5	4	2
85	H:H:?3	R:R:Y98	10.52	No	Yes	5	0	2
86	H:H:?3	R:R:N99	28.34	No	No	5	0	5
87	R:R:L100	R:R:V103	5.96	Yes	No	0	8	5
88	R:R:L100	R:R:L125	4.15	Yes	No	0	8	8
89	R:R:I106	R:R:V103	3.07	No	No	0	7	5
90	R:R:K129	R:R:T104	3	No	No	0	5	5
91	R:R:F130	R:R:H105	16.97	Yes	Yes	1	6	7
92	N:N:Y112	R:R:H105	8.71	Yes	Yes	1	5	7
93	R:R:E107	R:R:R109	18.61	No	Yes	1	6	5
94	R:R:E107	R:R:F134	7	No	Yes	1	6	5
95	R:R:I108	R:R:T111	4.56	No	No	0	8	5
96	R:R:N110	R:R:R109	7.23	Yes	Yes	1	6	5
97	R:R:F134	R:R:R109	14.97	Yes	Yes	1	5	5
98	L:L:D114	R:R:R109	8.34	Yes	Yes	1	9	5
99	L:L:I116	R:R:R109	5.01	Yes	Yes	1	7	5
100	R:R:N110	R:R:N135	5.45	Yes	Yes	1	6	8
101	N:N:M71	R:R:N110	8.41	No	Yes	1	9	6
102	L:L:D114	R:R:N110	5.39	Yes	Yes	1	9	6
103	R:R:L114	R:R:T111	5.9	Yes	No	2	8	5
104	R:R:T111	R:R:T136	3.14	No	Yes	2	5	9
105	N:N:L72	R:R:R112	7.29	No	No	0	3	6
106	R:R:L114	R:R:T136	5.9	Yes	Yes	2	8	9
107	R:R:L114	R:R:L138	4.15	Yes	Yes	2	8	8
108	R:R:K139	R:R:T115	6.01	No	No	0	4	4
109	R:R:D118	R:R:Y116	9.2	Yes	Yes	5	5	3
110	R:R:P119	R:R:Y116	4.17	No	Yes	5	4	3
111	R:R:M140	R:R:Y116	5.99	No	Yes	0	1	3
112	R:R:I117	R:R:L138	5.71	No	Yes	0	8	8
113	R:R:D118	R:R:P119	8.05	Yes	No	5	5	4
114	R:R:D118	R:R:D120	3.99	Yes	No	5	5	5
115	R:R:D143	R:R:P119	4.83	No	No	5	5	4
116	R:R:D120	R:R:K146	5.53	No	Yes	5	5	4
117	R:R:L122	R:R:L125	4.15	No	No	0	7	8
118	R:R:K123	R:R:K146	5.75	No	Yes	5	4	4
119	R:R:E124	R:R:Y148	7.86	No	No	0	4	4
120	R:R:L125	R:R:V147	2.98	No	No	0	8	7
121	R:R:L128	R:R:L131	4.15	No	No	0	9	8
122	R:R:L128	R:R:S149	3	No	No	2	9	8
123	R:R:F154	R:R:L128	6.09	Yes	No	2	6	9
124	R:R:D151	R:R:K129	15.21	No	No	0	4	5
125	R:R:F130	R:R:G132	3.01	Yes	No	1	6	5
126	R:R:F130	R:R:F134	3.22	Yes	Yes	1	6	5
127	R:R:F130	R:R:I155	6.28	Yes	No	0	6	5
128	R:R:E157	R:R:F130	4.66	Yes	Yes	1	8	6
129	N:N:Y112	R:R:F130	12.38	Yes	Yes	1	5	6
130	R:R:F134	R:R:G132	4.52	Yes	No	1	5	5
131	R:R:I133	R:R:T136	4.56	No	Yes	0	8	9
132	R:R:I133	R:R:I158	4.42	No	No	0	8	7
133	R:R:E157	R:R:F134	12.83	Yes	Yes	1	8	5
134	R:R:F134	R:R:T159	5.19	Yes	Yes	1	5	5
135	R:R:D160	R:R:N135	4.04	Yes	Yes	1	8	8
136	N:N:M71	R:R:N135	7.01	No	Yes	1	9	8
137	N:N:V73	R:R:N135	5.91	No	Yes	1	7	8
138	R:R:G137	R:R:T136	3.64	No	Yes	0	8	9
139	R:R:L138	R:R:T136	5.9	Yes	Yes	2	8	9
140	R:R:N161	R:R:T136	8.77	No	Yes	0	8	9
141	R:R:L138	R:R:M164	4.24	Yes	Yes	2	8	7
142	R:R:F141	R:R:P142	7.22	Yes	No	2	7	9
143	R:R:F141	R:R:I158	5.02	Yes	No	0	7	7
144	R:R:F141	R:R:M164	6.22	Yes	Yes	2	7	7
145	R:R:F141	R:R:P168	8.67	Yes	No	0	7	6
146	R:R:F141	R:R:F172	4.29	Yes	Yes	2	7	8
147	R:R:F141	R:R:F189	4.29	Yes	Yes	2	7	8
148	R:R:M164	R:R:P142	3.35	Yes	No	2	7	9
149	R:R:D143	R:R:T145	10.12	No	No	5	5	4
150	R:R:D143	R:R:K146	8.3	No	Yes	5	5	4
151	R:R:L144	R:R:L156	4.15	No	Yes	2	7	7
152	R:R:L144	R:R:L175	11.07	No	Yes	2	7	7
153	R:R:K146	R:R:T145	7.51	Yes	No	5	4	4
154	R:R:K146	R:R:Y148	5.97	Yes	No	0	4	4
155	R:R:L175	R:R:V147	4.47	Yes	No	0	7	7
156	R:R:F154	R:R:S149	5.28	Yes	No	2	6	8
157	R:R:C176	R:R:S149	5.16	No	No	2	6	8
158	R:R:N177	R:R:T150	4.39	No	No	2	5	3
159	H:H:?2	R:R:T150	5.29	No	No	2	0	3
160	R:R:F153	R:R:I152	5.02	Yes	No	0	5	3
161	R:R:E178	R:R:I152	9.56	Yes	No	0	5	3
162	N:N:Y113	R:R:F153	4.13	Yes	Yes	0	4	5
163	L:L:K59	R:R:F153	13.65	No	Yes	0	5	5
164	L:L:K64	R:R:F153	22.33	No	Yes	0	5	5
165	R:R:F154	R:R:L156	3.65	Yes	Yes	2	6	7
166	R:R:F154	R:R:L175	8.53	Yes	Yes	2	6	7
167	R:R:C176	R:R:F154	8.38	No	Yes	2	6	6
168	R:R:F154	R:R:L180	3.65	Yes	Yes	2	6	7
169	R:R:I155	R:R:T181	4.56	No	No	0	5	7
170	R:R:L156	R:R:L175	5.54	Yes	Yes	2	7	7
171	R:R:L156	R:R:L182	4.15	Yes	Yes	2	7	6
172	R:R:E157	R:R:T159	4.23	Yes	Yes	1	8	5
173	R:R:E157	R:R:K183	12.15	Yes	Yes	1	8	6
174	R:R:E157	R:R:Y185	6.73	Yes	Yes	1	8	7
175	N:N:K115	R:R:E157	9.45	Yes	Yes	1	9	8
176	R:R:I158	R:R:N187	4.25	No	Yes	0	7	9
177	R:R:D160	R:R:T159	4.34	Yes	Yes	1	8	5
178	R:R:T159	R:R:Y185	11.24	Yes	Yes	1	5	7
179	R:R:D160	R:R:N186	5.39	Yes	No	0	8	7
180	N:N:V73	R:R:D160	4.38	No	Yes	1	7	8
181	N:N:K75	R:R:D160	9.68	No	Yes	0	9	8
182	R:R:M164	R:R:N161	5.61	Yes	No	0	7	8
183	R:R:N161	R:R:N187	6.81	No	Yes	0	8	9
184	R:R:P162	R:R:Y163	6.95	No	No	1	7	4
185	N:N:L72	R:R:P162	8.21	No	No	1	3	7
186	N:N:V73	R:R:P162	5.3	No	No	1	7	7
187	N:N:L72	R:R:Y163	5.86	No	No	1	3	4
188	R:R:F189	R:R:M164	4.98	Yes	Yes	2	8	7
189	R:R:Q193	R:R:S166	4.33	No	No	0	5	5
190	R:R:I167	R:R:P168	3.39	No	No	0	7	6
191	R:R:F189	R:R:I167	12.56	Yes	No	0	8	7
192	R:R:I167	R:R:V192	7.68	No	No	0	7	7
193	R:R:A171	R:R:P168	3.74	No	No	0	7	6
194	R:R:N170	R:R:V169	5.91	Yes	No	10	8	5
195	H:H:?1	R:R:V169	4.01	Yes	No	10	0	5
196	R:R:N170	R:R:Q173	10.56	Yes	Yes	10	8	2
197	R:R:N170	R:R:N198	8.17	Yes	Yes	10	8	7
198	H:H:?1	R:R:N170	16.02	Yes	Yes	10	0	8
199	R:R:A171	R:R:F172	5.55	No	Yes	0	7	8
200	R:R:F172	R:R:L182	12.18	Yes	Yes	2	8	6
201	R:R:F172	R:R:L184	3.65	Yes	No	2	8	8
202	R:R:F172	R:R:F197	6.43	Yes	Yes	0	8	9
203	R:R:F172	R:R:T200	3.89	Yes	Yes	2	8	8
204	R:R:N198	R:R:Q173	9.24	Yes	Yes	10	7	2
205	R:R:G199	R:R:Q173	3.29	No	Yes	0	7	2
206	H:H:?1	R:R:Q173	10.75	Yes	Yes	10	0	2
207	R:R:L175	R:R:L180	4.15	Yes	Yes	2	7	7
208	R:R:C176	R:R:E178	3.04	No	Yes	2	6	5
209	R:R:E178	R:R:N177	3.94	Yes	No	2	5	5
210	H:H:?2	R:R:N177	27.11	No	No	2	0	5
211	H:H:?2	R:R:E178	15.46	No	Yes	2	0	5
212	R:R:K201	R:R:T179	3	No	No	0	4	5
213	R:R:D203	R:R:T179	14.45	No	No	18	6	5
214	L:L:K64	R:R:T179	4.5	No	No	18	5	5
215	R:R:L180	R:R:L182	4.15	Yes	Yes	2	7	6
216	R:R:L180	R:R:T200	2.95	Yes	Yes	2	7	8
217	R:R:K183	R:R:T181	3	Yes	No	0	6	7
218	R:R:D203	R:R:T181	4.34	No	No	0	6	7
219	R:R:L182	R:R:L184	4.15	Yes	No	2	6	8
220	R:R:L182	R:R:V205	4.47	Yes	Yes	2	6	7
221	R:R:K183	R:R:Y185	8.36	Yes	Yes	1	6	7
222	R:R:K183	R:R:Y206	3.58	Yes	Yes	1	6	6
223	R:R:N208	R:R:Y185	5.81	Yes	Yes	1	5	7
224	R:R:K209	R:R:N186	4.2	Yes	No	0	7	7
225	R:R:F189	R:R:N187	15.71	Yes	Yes	2	8	9
226	R:R:N187	R:R:N210	4.09	Yes	No	2	9	9
227	R:R:F189	R:R:N210	4.83	Yes	No	2	8	9
228	R:R:S191	R:R:V215	3.23	No	No	0	4	2
229	R:R:I216	R:R:V192	4.61	No	No	0	6	7
230	R:R:D217	R:R:G194	5.03	No	No	0	5	3
231	R:R:N198	R:R:Y195	3.49	Yes	Yes	10	7	4
232	R:R:D219	R:R:Y195	5.75	No	Yes	0	3	4
233	H:H:?1	R:R:Y195	9.47	Yes	Yes	10	0	4
234	R:R:F197	R:R:L202	3.65	Yes	Yes	0	9	8
235	R:R:F197	R:R:F221	13.93	Yes	Yes	0	9	9
236	R:R:G223	R:R:N198	3.39	No	Yes	0	7	7
237	H:H:?1	R:R:N198	24.64	Yes	Yes	10	0	7
238	R:R:G199	R:R:Y225	7.24	No	No	0	7	4
239	R:R:L202	R:R:T200	8.84	Yes	Yes	2	8	8
240	R:R:T200	R:R:V224	4.76	Yes	No	2	8	7
241	R:R:K201	R:R:Y225	4.78	No	No	0	4	4
242	R:R:K201	R:R:S226	4.59	No	No	0	4	4
243	R:R:L202	R:R:V205	2.98	Yes	Yes	2	8	7
244	R:R:L202	R:R:V224	4.47	Yes	No	2	8	7
245	R:R:L202	R:R:P228	6.57	Yes	Yes	2	8	8
246	L:L:K64	R:R:D203	20.74	No	No	18	5	6
247	R:R:A204	R:R:Y206	5.34	No	Yes	1	5	6
248	R:R:A204	R:R:L230	3.15	No	Yes	1	5	4
249	L:L:Y65	R:R:A204	4	Yes	No	1	4	5
250	R:R:L207	R:R:V205	2.98	No	Yes	0	7	7
251	R:R:P228	R:R:V205	5.3	Yes	Yes	2	8	7
252	R:R:L231	R:R:V205	2.98	No	Yes	0	7	7
253	R:R:N208	R:R:Y206	3.49	Yes	Yes	1	5	6
254	R:R:L230	R:R:Y206	5.86	Yes	Yes	1	4	6
255	R:R:D232	R:R:Y206	5.75	Yes	Yes	1	9	6
256	R:R:K209	R:R:N208	6.99	Yes	Yes	0	7	5
257	R:R:D232	R:R:N208	14.81	Yes	Yes	1	9	5
258	R:R:N208	R:R:S234	2.98	Yes	Yes	1	5	9
259	N:N:S116	R:R:K209	3.06	No	Yes	0	9	7
260	L:L:T110	R:R:K209	4.5	No	Yes	0	7	7
261	L:L:D111	R:R:K209	5.53	No	Yes	0	6	7
262	R:R:L213	R:R:N210	4.12	No	No	0	9	9
263	R:R:L213	R:R:T236	4.42	No	No	0	9	9
264	R:R:A220	R:R:I216	3.25	No	No	0	8	6
265	R:R:I216	R:R:P242	8.47	No	No	0	6	9
266	R:R:D219	R:R:K218	9.68	No	No	0	3	4
267	R:R:F221	R:R:P228	5.78	Yes	Yes	2	9	8
268	R:R:F221	R:R:L246	6.09	Yes	Yes	2	9	7
269	R:R:G227	R:R:P228	4.06	No	Yes	0	7	8
270	R:R:G227	R:R:H248	4.77	No	No	0	7	4
271	R:R:L246	R:R:P228	3.28	Yes	Yes	2	7	8
272	R:R:E251	R:R:L230	5.3	No	Yes	1	5	4
273	R:R:I253	R:R:L230	4.28	Yes	Yes	1	4	4
274	L:L:Y65	R:R:L230	11.72	Yes	Yes	1	4	4
275	R:R:L231	R:R:V233	4.47	No	Yes	0	7	7
276	R:R:D232	R:R:S234	7.36	Yes	Yes	1	9	9
277	R:R:D232	R:R:I253	13.99	Yes	Yes	1	9	4
278	R:R:V233	R:R:V238	3.21	Yes	No	19	7	7
279	R:R:L241	R:R:V233	2.98	Yes	Yes	19	9	7
280	R:R:I253	R:R:S234	3.1	Yes	Yes	1	4	9
281	R:R:R255	R:R:S234	3.95	Yes	Yes	1	4	9
282	R:R:T236	R:R:V238	6.35	No	No	0	9	7
283	R:R:T236	R:R:T257	3.14	No	No	0	9	8
284	R:R:S237	R:R:T259	3.2	No	No	0	4	5
285	R:R:L241	R:R:V238	2.98	Yes	No	19	9	7
286	R:R:L241	R:R:L260	6.92	Yes	No	0	9	9
287	R:R:L241	R:R:P264	3.28	Yes	Yes	0	9	9
288	R:R:L246	R:R:P242	4.93	Yes	No	0	7	9
289	R:R:P264	R:R:S243	3.56	Yes	No	0	9	5
290	R:R:E247	R:R:H248	3.69	No	No	0	4	4
291	R:R:E247	R:R:H271	9.85	No	No	0	4	5
292	R:R:H271	R:R:K250	6.55	No	No	0	5	7
293	R:R:K250	R:R:T273	6.01	No	No	0	7	4
294	R:R:E251	R:R:R274	12.79	No	Yes	1	5	3
295	L:L:Y65	R:R:E251	13.47	Yes	No	1	4	5
296	R:R:I253	R:R:R255	6.26	Yes	Yes	1	4	4
297	R:R:I253	R:R:R274	6.26	Yes	Yes	1	4	3
298	R:R:R255	R:R:R274	3.2	Yes	Yes	1	4	3
299	R:R:D276	R:R:R255	5.96	No	Yes	1	4	4
300	R:R:N256	R:R:W258	3.39	No	No	0	5	4
301	R:R:L260	R:R:T257	4.42	No	No	0	9	8
302	R:R:S278	R:R:W258	3.71	No	No	12	9	4
303	R:R:W258	R:R:Y279	7.72	No	Yes	12	4	9
304	R:R:K261	R:R:Y279	5.97	No	Yes	12	8	9
305	R:R:I486	R:R:K261	8.72	Yes	No	12	8	8
306	R:R:K262	R:R:N483	6.99	No	No	0	5	8
307	R:R:D487	R:R:K262	4.15	No	No	0	6	5
308	R:R:L263	R:R:P264	3.28	No	Yes	0	8	9
309	R:R:H282	R:R:L263	6.43	No	No	0	9	8
310	R:R:F286	R:R:L263	3.65	Yes	No	0	8	8
311	R:R:P264	R:R:S268	3.56	Yes	No	0	9	5
312	R:R:F269	R:R:P264	8.67	Yes	Yes	0	7	9
313	R:R:F269	R:R:L272	3.65	Yes	No	15	7	8
314	R:R:F269	R:R:F286	3.22	Yes	Yes	15	7	8
315	R:R:F286	R:R:L272	3.65	Yes	No	15	8	8
316	R:R:L272	R:R:M396	4.24	No	No	15	8	6
317	R:R:D392	R:R:T273	5.78	No	No	0	4	4
318	R:R:D276	R:R:R274	14.29	No	Yes	1	4	3
319	R:R:A275	R:R:L277	3.15	No	No	0	9	9
320	R:R:A275	R:R:F286	4.16	No	Yes	0	9	8
321	R:R:D276	R:R:T399	7.23	No	No	0	4	4
322	R:R:H282	R:R:L277	3.86	No	No	0	9	9
323	R:R:S278	R:R:Y279	3.82	No	Yes	12	9	9
324	R:R:H282	R:R:Y279	6.53	No	Yes	0	9	9
325	R:R:I486	R:R:Y279	13.3	Yes	Yes	12	8	9
326	R:R:P280	R:R:P400	3.9	No	No	0	8	9
327	R:R:A485	R:R:I281	3.25	No	No	0	9	9
328	R:R:I281	R:R:I486	2.94	No	Yes	0	9	8
329	R:R:C283	R:R:C398	7.28	No	No	0	9	9
330	R:R:C284	R:R:C408	7.28	No	No	0	9	9
331	R:R:C284	R:R:Y482	4.03	No	Yes	0	9	8
332	R:R:A285	R:R:Y482	6.67	No	Yes	0	8	8
333	R:R:F286	R:R:M396	9.95	Yes	No	15	8	6
334	R:R:M396	R:R:Q289	8.16	No	No	0	6	7
335	R:R:D395	R:R:K290	4.15	No	No	0	3	5
336	N:N:F42	R:R:S383	5.28	Yes	No	11	6	4
337	L:L:I56	R:R:S383	4.64	No	No	11	5	4
338	L:L:L62	R:R:S383	3	Yes	No	11	3	4
339	N:N:F41	R:R:H384	5.66	No	No	0	1	3
340	R:R:D386	R:R:Y385	4.6	No	No	0	5	4
341	R:R:I389	R:R:Y385	8.46	No	No	0	4	4
342	L:L:L62	R:R:D386	5.43	Yes	No	0	3	5
343	N:N:F41	R:R:Y387	16.5	No	No	0	1	4
344	N:N:F98	R:R:Y387	7.22	No	No	0	3	4
345	L:L:F61	R:R:Y387	29.91	No	No	0	3	4
346	N:N:F41	R:R:T388	7.78	No	No	0	1	4
347	R:R:D392	R:R:S393	4.42	No	No	0	4	3
348	R:R:E394	R:R:S393	4.31	No	No	0	5	3
349	R:R:D395	R:R:E394	6.5	No	No	0	3	5
350	R:R:D403	R:R:E404	9.09	No	No	0	8	7
351	R:R:D403	R:R:F405	8.36	No	Yes	0	8	8
352	R:R:F405	R:R:K565	14.89	Yes	No	0	8	7
353	R:R:F405	R:R:M572	3.73	Yes	Yes	3	8	9
354	R:R:F405	W:W:?1	3.91	Yes	Yes	3	8	0
355	R:R:E409	R:R:P407	11	Yes	No	20	9	9
356	R:R:P407	R:R:V656	7.07	No	No	0	9	7
357	R:R:P407	R:R:S657	3.56	No	No	20	9	8
358	R:R:E409	R:R:G413	6.55	Yes	No	0	9	9
359	R:R:E409	R:R:S657	8.62	Yes	No	20	9	8
360	R:R:E409	R:R:K660	6.75	Yes	No	0	9	9
361	R:R:D410	R:R:R418	8.34	No	No	21	9	9
362	R:R:D410	R:R:H478	5.04	No	No	21	9	5
363	R:R:I411	R:R:I470	2.94	Yes	No	0	8	8
364	R:R:I411	R:R:V473	3.07	Yes	No	0	8	8
365	R:R:D474	R:R:I411	5.6	No	Yes	0	9	8
366	R:R:I411	R:R:Y481	7.25	Yes	Yes	8	8	8
367	R:R:I411	R:R:S567	3.1	Yes	No	8	8	9
368	R:R:M412	R:R:V421	6.09	No	Yes	0	8	9
369	R:R:D474	R:R:M412	9.7	No	No	0	9	8
370	R:R:F416	R:R:Y414	9.28	No	Yes	22	6	4
371	R:R:L417	R:R:Y414	3.52	No	Yes	22	9	4
372	R:R:N658	R:R:Y414	5.81	No	Yes	0	8	4
373	R:R:I661	R:R:Y414	4.84	No	Yes	0	9	4
374	R:R:F416	R:R:L417	7.31	No	No	22	6	9
375	R:R:L417	R:R:V664	5.96	No	No	0	9	9
376	R:R:D474	R:R:R418	14.29	No	No	0	9	9
377	R:R:H478	R:R:R418	5.64	No	No	21	5	9
378	R:R:V420	R:R:V664	3.21	No	No	0	6	9
379	R:R:L467	R:R:V421	2.98	Yes	Yes	0	9	9
380	R:R:A471	R:R:V421	3.39	No	Yes	0	9	9
381	R:R:V421	R:R:V664	4.81	Yes	No	0	9	9
382	R:R:L468	R:R:W422	3.42	No	No	0	7	9
383	R:R:A471	R:R:W422	6.48	No	No	0	9	9
384	R:R:L475	R:R:W422	4.56	No	No	0	4	9
385	R:R:P668	R:R:V424	3.53	Yes	No	0	9	9
386	R:R:L467	R:R:S425	3	Yes	No	0	9	8
387	R:R:L468	R:R:S425	4.5	No	No	0	7	8
388	R:R:L426	R:R:L430	5.54	No	No	0	6	5
389	R:R:C672	R:R:L427	6.35	No	No	0	9	7
390	R:R:A428	R:R:S671	3.42	No	No	0	9	9
391	R:R:F461	R:R:L429	3.65	No	Yes	0	5	7
392	R:R:G464	R:R:L429	3.42	No	Yes	0	9	7
393	R:R:L429	R:R:L468	4.15	Yes	No	0	7	7
394	R:R:A457	R:R:N432	4.69	No	No	0	9	9
395	R:R:D460	R:R:N432	6.73	Yes	No	0	9	9
396	R:R:N432	R:R:P675	9.77	No	No	0	9	9
397	R:R:L437	R:R:V433	2.98	No	No	0	3	3
398	R:R:F434	R:R:I438	7.54	No	Yes	7	7	8
399	R:R:F434	R:R:F685	4.29	No	Yes	7	7	9
400	R:R:L439	R:R:V435	2.98	Yes	Yes	7	8	9
401	R:R:A457	R:R:V435	3.39	No	Yes	0	9	9
402	R:R:A679	R:R:V435	5.09	No	Yes	0	9	9
403	R:R:I680	R:R:V435	3.07	No	Yes	7	9	9
404	R:R:F685	R:R:V435	5.24	Yes	Yes	7	9	9
405	R:R:A457	R:R:L436	4.73	No	No	0	9	5
406	R:R:F685	R:R:I438	11.3	Yes	Yes	7	9	8
407	R:R:I438	R:R:V689	3.07	Yes	Yes	7	8	5
408	R:R:L439	R:R:R450	3.64	Yes	Yes	0	8	9
409	R:R:C454	R:R:L439	4.76	No	Yes	0	8	8
410	R:R:F685	R:R:L439	4.87	Yes	Yes	7	9	8
411	R:R:C454	R:R:L440	3.17	No	No	0	8	6
412	R:R:L692	R:R:T441	2.95	No	No	0	8	7
413	R:R:D688	R:R:S442	11.78	No	No	0	9	8
414	R:R:H443	R:R:I691	5.3	No	No	0	5	6
415	R:R:R450	R:R:Y444	3.09	Yes	No	0	9	7
416	R:R:R687	R:R:Y444	18.52	No	No	0	7	7
417	R:R:L446	R:R:R450	4.86	No	Yes	0	6	9
418	R:R:F451	R:R:L446	3.65	Yes	No	0	9	6
419	R:R:N447	R:R:P449	11.4	No	No	0	8	8
420	R:R:N447	R:R:R450	10.85	No	Yes	0	8	9
421	R:R:P449	R:R:V448	3.53	No	Yes	4	8	9
422	R:R:L452	R:R:V448	2.98	No	Yes	4	9	9
423	R:R:E518	R:R:V448	5.7	No	Yes	4	9	9
424	R:R:L535	R:R:V448	2.98	No	Yes	0	7	9
425	R:R:A538	R:R:V448	5.09	No	Yes	0	9	9
426	R:R:E518	R:R:P449	11	No	No	4	9	8
427	R:R:F451	R:R:N455	8.46	Yes	No	4	9	8
428	R:R:F451	R:R:L535	4.87	Yes	No	0	9	7
429	R:R:C539	R:R:F451	4.19	No	Yes	0	4	9
430	R:R:F451	R:R:M542	6.22	Yes	Yes	4	9	9
431	R:R:I515	R:R:L452	5.71	No	No	4	9	9
432	R:R:E518	R:R:L452	3.98	No	No	4	9	9
433	R:R:M542	R:R:N455	8.41	Yes	No	4	9	8
434	R:R:N455	R:R:W546	5.65	No	Yes	4	8	9
435	R:R:D460	R:R:L456	5.43	Yes	Yes	4	9	9
436	R:R:L456	R:R:T511	5.9	Yes	Yes	4	9	9
437	R:R:L456	R:R:L512	4.15	Yes	No	4	9	9
438	R:R:I515	R:R:L456	5.71	No	Yes	4	9	9
439	R:R:L456	R:R:N674	10.98	Yes	Yes	4	9	9
440	R:R:L456	R:R:Y678	3.52	Yes	Yes	4	9	9
441	R:R:C462	R:R:F458	6.98	No	No	0	7	7
442	R:R:F458	R:R:W546	9.02	No	Yes	0	7	9
443	R:R:A459	R:R:L507	4.73	No	Yes	0	9	9
444	R:R:D460	R:R:S508	5.89	Yes	No	0	9	9
445	R:R:D460	R:R:S671	4.42	Yes	No	0	9	9
446	R:R:D460	R:R:N674	9.42	Yes	Yes	4	9	9
447	R:R:M463	R:R:Y466	3.59	Yes	Yes	3	9	9
448	R:R:L467	R:R:M463	4.24	Yes	Yes	3	9	9
449	R:R:M463	R:R:Y667	9.58	Yes	Yes	3	9	9
450	R:R:M463	R:R:P668	3.35	Yes	Yes	3	9	9
451	R:R:M463	R:R:S671	6.13	Yes	No	0	9	9
452	R:R:F500	R:R:M465	7.46	No	No	0	7	4
453	R:R:L467	R:R:Y466	3.52	Yes	Yes	3	9	9
454	R:R:I470	R:R:Y466	8.46	No	Yes	0	8	9
455	R:R:T501	R:R:Y466	8.74	Yes	Yes	0	9	9
456	R:R:L663	R:R:Y466	5.86	Yes	Yes	3	9	9
457	R:R:L467	R:R:P668	4.93	Yes	Yes	3	9	9
458	R:R:A497	R:R:L469	3.15	No	No	0	9	7
459	R:R:V473	R:R:W488	11.03	No	Yes	0	8	9
460	R:R:T477	R:R:Y476	3.75	No	No	8	9	5
461	R:R:H484	R:R:Y476	6.53	No	No	8	6	5
462	R:R:T477	R:R:Y481	3.75	No	Yes	8	9	8
463	R:R:H484	R:R:T477	9.58	No	No	8	6	9
464	R:R:H478	R:R:S479	5.58	No	No	0	5	7
465	R:R:E480	R:R:H484	8.62	No	No	0	6	6
466	R:R:A485	R:R:Y481	6.67	No	Yes	0	9	8
467	R:R:W488	R:R:Y481	4.82	Yes	Yes	8	9	8
468	R:R:Q489	R:R:Y481	5.64	No	Yes	0	9	8
469	R:R:S567	R:R:Y481	5.09	No	Yes	8	9	8
470	R:R:N483	R:R:Y482	9.3	No	Yes	0	8	8
471	R:R:G493	R:R:W488	4.22	No	Yes	0	9	9
472	R:R:C494	R:R:W488	7.84	No	Yes	8	9	9
473	R:R:C569	R:R:W488	3.92	No	Yes	8	9	9
474	R:R:G491	R:R:P492	4.06	No	No	0	8	3
475	R:R:G493	R:R:T496	3.64	No	No	0	9	5
476	R:R:C494	R:R:C569	7.28	No	No	8	9	9
477	R:R:L557	R:R:N495	4.12	No	No	0	7	5
478	R:R:A497	R:R:C569	3.61	No	No	0	9	9
479	R:R:G498	R:R:T501	3.64	No	Yes	0	9	9
480	R:R:G498	R:R:Y563	10.14	No	Yes	0	9	9
481	R:R:F499	R:R:F550	3.22	No	No	0	8	4
482	R:R:A553	R:R:F499	5.55	No	No	0	9	8
483	R:R:T501	R:R:V502	3.17	Yes	Yes	0	9	9
484	R:R:L570	R:R:T501	2.95	Yes	Yes	0	9	9
485	R:R:T501	R:R:Y667	3.75	Yes	Yes	0	9	9
486	R:R:A553	R:R:V502	3.39	No	Yes	0	9	9
487	R:R:V502	R:R:Y563	5.05	Yes	Yes	3	9	9
488	R:R:P571	R:R:V502	3.53	No	Yes	3	9	9
489	R:R:V502	R:R:Y582	3.79	Yes	Yes	3	9	9
490	R:R:F503	R:R:W546	4.01	No	Yes	0	9	9
491	R:R:S505	R:R:Y667	6.36	No	Yes	0	9	9
492	R:R:C549	R:R:E506	3.04	No	Yes	0	8	8
493	R:R:E506	R:R:L552	3.98	Yes	No	3	8	7
494	R:R:E506	R:R:V586	8.56	Yes	Yes	3	8	7
495	R:R:E506	R:R:N590	11.83	Yes	No	0	8	9
496	R:R:L507	R:R:T511	2.95	Yes	Yes	0	9	9
497	R:R:L507	R:R:W546	10.25	Yes	Yes	0	9	9
498	R:R:C549	R:R:L507	4.76	No	Yes	0	8	9
499	R:R:N590	R:R:V509	8.87	No	No	0	9	8
500	R:R:V514	R:R:Y510	3.79	No	No	0	6	7
501	R:R:G545	R:R:Y510	10.14	No	No	0	9	7
502	R:R:I515	R:R:T511	3.04	No	Yes	4	9	9
503	R:R:M542	R:R:T511	3.01	Yes	Yes	4	9	9
504	R:R:D633	R:R:L512	4.07	Yes	No	0	8	9
505	R:R:L512	R:R:Y678	7.03	No	Yes	4	9	9
506	R:R:I596	R:R:T513	4.56	No	No	0	6	9
507	R:R:I541	R:R:V514	3.07	No	No	0	7	6
508	R:R:M542	R:R:V514	3.04	Yes	No	0	9	6
509	R:R:T516	R:R:V597	9.52	No	No	0	9	9
510	R:R:C600	R:R:T516	3.38	No	No	0	9	9
511	R:R:T516	R:R:Y601	12.48	No	Yes	0	9	9
512	R:R:I596	R:R:L517	4.28	No	No	0	6	5
513	R:R:C600	R:R:L517	3.17	No	No	0	9	5
514	R:R:R519	R:R:Y601	8.23	No	Yes	4	9	9
515	R:R:R519	R:R:Y678	7.2	No	Yes	4	9	9
516	R:R:T524	R:R:W520	10.92	No	Yes	0	8	7
517	R:R:C600	R:R:W520	3.92	No	Yes	0	9	7
518	R:R:I604	R:R:W520	3.52	No	Yes	0	9	7
519	R:R:F525	R:R:Y521	16.5	No	No	0	6	6
520	R:R:R531	R:R:Y521	7.2	No	No	0	7	6
521	R:R:I533	R:R:Y521	6.04	No	No	0	5	6
522	R:R:I523	R:R:I604	4.42	No	No	0	9	9
523	R:R:I523	R:R:T607	3.04	No	No	0	9	7
524	R:R:F525	R:R:T524	3.89	No	No	0	6	8
525	R:R:D530	R:R:R528	14.29	No	No	23	8	7
526	R:R:R528	R:R:R531	7.46	No	No	23	7	7
527	R:R:D530	R:R:R531	4.76	No	No	23	8	7
528	R:R:L535	R:R:R534	3.64	No	No	0	7	7
529	R:R:R534	R:R:R536	8.53	No	No	0	7	5
530	R:R:H537	R:R:R536	3.39	No	No	0	7	5
531	R:R:M542	R:R:W546	3.49	Yes	Yes	4	9	9
532	R:R:L552	R:R:V586	2.98	No	Yes	3	7	7
533	R:R:L554	R:R:V558	2.98	No	No	0	5	4
534	R:R:I560	R:R:L555	5.71	No	No	3	7	7
535	R:R:L555	R:R:Y582	4.69	No	Yes	3	7	9
536	R:R:P556	R:R:Y563	18.08	No	Yes	0	9	9
537	R:R:P556	R:R:Y582	11.13	No	Yes	0	9	9
538	R:R:L557	R:R:Y563	3.52	No	Yes	0	7	9
539	R:R:I560	R:R:Y582	3.63	No	Yes	3	7	9
540	R:R:D573	R:R:S561	2.94	No	No	0	8	9
541	R:R:S561	R:R:Y582	3.82	No	Yes	0	9	9
542	R:R:D573	R:R:S562	8.83	No	No	0	8	8
543	R:R:P571	R:R:Y563	8.34	No	Yes	3	9	9
544	R:R:E575	R:R:K565	6.75	No	No	0	4	7
545	R:R:I568	R:R:V566	3.07	Yes	No	0	9	9
546	R:R:M572	R:R:V566	6.09	Yes	No	0	9	9
547	R:R:K660	R:R:S567	3.06	No	No	0	9	9
548	R:R:I568	R:R:L570	5.71	Yes	Yes	3	9	9
549	R:R:I568	R:R:K660	4.36	Yes	No	0	9	9
550	R:R:I568	R:R:L663	7.14	Yes	Yes	3	9	9
551	R:R:L570	R:R:M572	4.24	Yes	Yes	3	9	9
552	R:R:L570	R:R:L663	4.15	Yes	Yes	3	9	9
553	R:R:L570	W:W:?1	13.32	Yes	Yes	3	9	0
554	R:R:P571	W:W:?1	8.43	No	Yes	3	9	0
555	R:R:M572	W:W:?1	15.42	Yes	Yes	3	9	0
556	R:R:D573	R:R:E575	10.39	No	No	0	8	4
557	R:R:P577	R:R:T576	5.25	No	No	0	3	6
558	R:R:A579	R:R:T576	3.36	No	No	0	8	6
559	R:R:L580	R:R:V584	2.98	No	No	0	4	5
560	R:R:V586	R:R:Y582	5.05	Yes	Yes	3	7	9
561	R:R:I583	R:R:I648	2.94	No	Yes	3	7	6
562	R:R:I583	W:W:?1	7.33	No	Yes	3	7	0
563	R:R:F585	R:R:L589	13.4	No	No	0	4	3
564	R:R:V586	W:W:?1	3.82	Yes	Yes	3	7	0
565	R:R:A644	R:R:L587	4.73	No	No	3	9	8
566	R:R:L587	W:W:?1	7.99	No	Yes	3	8	0
567	R:R:I591	R:R:S641	4.64	No	No	0	6	9
568	R:R:I596	R:R:V592	3.07	No	No	0	6	3
569	R:R:C598	R:R:F594	5.59	No	Yes	0	7	8
570	R:R:D633	R:R:F594	5.97	Yes	Yes	0	8	8
571	R:R:F594	R:R:F634	7.5	Yes	No	0	8	9
572	R:R:F594	R:R:M637	12.44	Yes	No	0	8	7
573	R:R:D633	R:R:V597	4.38	Yes	No	0	8	9
574	R:R:M626	R:R:Y601	7.18	No	Yes	0	9	9
575	R:R:L629	R:R:Y601	5.86	No	Yes	4	9	9
576	R:R:I630	R:R:Y601	3.63	No	Yes	0	9	9
577	R:R:Y601	R:R:Y678	2.98	Yes	Yes	4	9	9
578	R:R:R609	R:R:Y605	5.14	No	No	0	7	9
579	R:R:M626	R:R:Y605	3.59	No	No	0	9	9
580	R:R:T607	R:R:V608	3.17	No	No	0	7	9
581	R:R:D619	R:R:R609	4.76	No	No	0	9	7
582	R:R:N610	R:R:P611	3.26	No	No	0	6	8
583	R:R:D617	R:R:K618	12.44	No	No	0	6	6
584	R:R:I622	R:R:M626	5.83	No	No	0	8	9
585	R:R:L677	R:R:V628	4.47	No	No	0	9	6
586	R:R:L629	R:R:L677	4.15	No	No	0	9	9
587	R:R:L629	R:R:Y678	7.03	No	Yes	4	9	9
588	R:R:F631	R:R:I635	8.79	No	No	0	8	6
589	R:R:L677	R:R:T632	4.42	No	No	0	9	9
590	R:R:D633	R:R:N670	6.73	Yes	No	0	8	9
591	R:R:A638	R:R:F634	8.32	No	No	0	8	9
592	R:R:C636	R:R:L669	3.17	No	No	0	9	8
593	R:R:C636	R:R:N670	11.02	No	No	0	9	9
594	R:R:A638	R:R:P639	3.74	No	No	0	8	9
595	R:R:F666	R:R:P639	5.78	No	No	0	8	9
596	R:R:I640	R:R:Y667	3.63	No	Yes	0	9	9
597	R:R:I640	W:W:?1	7.33	No	Yes	0	9	0
598	R:R:F642	R:R:Y643	10.32	No	Yes	0	9	8
599	R:R:L653	R:R:Y643	3.52	No	Yes	0	9	8
600	R:R:I654	R:R:Y643	12.09	No	Yes	0	9	8
601	R:R:L662	R:R:Y643	5.86	No	Yes	0	8	8
602	R:R:A644	W:W:?1	5.05	No	Yes	3	9	0
603	R:R:L653	R:R:S646	4.5	No	No	0	9	9
604	R:R:A647	W:W:?1	6.07	No	Yes	0	9	0
605	R:R:I648	W:W:?1	5.49	Yes	Yes	3	6	0
606	R:R:P652	W:W:?1	3.16	No	Yes	0	9	0
607	R:R:S657	R:R:T655	3.2	No	No	0	8	8
608	R:R:N658	R:R:T655	5.85	No	No	0	8	8
609	R:R:S659	R:R:V656	3.23	No	No	0	9	7
610	R:R:S659	W:W:?1	5.78	No	Yes	0	9	0
611	R:R:L662	W:W:?1	4.44	No	Yes	0	8	0
612	R:R:L663	R:R:Y667	3.52	Yes	Yes	3	9	9
613	R:R:F666	R:R:L665	3.65	No	No	0	8	8
614	R:R:P668	R:R:Y667	6.95	Yes	Yes	3	9	9
615	R:R:N670	R:R:N674	6.81	No	Yes	0	9	9
616	R:R:N674	R:R:Y678	4.65	Yes	Yes	4	9	9
617	R:R:F676	R:R:I680	5.02	No	No	7	8	9
618	R:R:F676	R:R:F681	3.22	No	No	7	8	8
619	R:R:F681	R:R:I680	11.3	No	No	7	8	9
620	R:R:F685	R:R:T682	3.89	Yes	No	0	9	9
621	R:R:F685	R:R:V689	3.93	Yes	Yes	7	9	5
622	R:R:D688	R:R:R687	7.15	No	No	0	9	7
623	R:R:L693	R:R:V689	2.98	No	Yes	0	7	5
624	L:L:F21	N:N:D30	5.97	No	No	0	1	5
625	N:N:C31	N:N:C55	7.28	No	No	0	9	9
626	L:L:F21	N:N:C31	4.19	No	No	0	1	9
627	L:L:M52	N:N:P32	3.35	No	No	0	1	5
628	N:N:E33	N:N:T35	4.23	No	No	0	7	5
629	N:N:C34	N:N:C84	5.46	No	Yes	13	9	9
630	N:N:C108	N:N:C34	7.28	Yes	No	13	9	9
631	N:N:Q37	N:N:T35	8.5	No	No	0	4	5
632	N:N:C106	N:N:L36	4.76	No	No	0	9	9
633	N:N:M53	N:N:Q37	4.08	Yes	No	0	4	4
634	N:N:E38	N:N:S43	8.62	No	No	0	4	8
635	N:N:E38	N:N:P48	4.72	No	No	0	4	6
636	N:N:N39	N:N:P40	4.89	No	No	0	8	1
637	N:N:F42	N:N:N39	25.37	Yes	No	0	6	8
638	L:L:R54	N:N:N39	3.62	No	No	0	5	8
639	L:L:N57	N:N:F42	3.62	Yes	Yes	0	7	6
640	L:L:G58	N:N:F42	4.52	No	Yes	11	2	6
641	L:L:F61	N:N:F42	5.36	No	Yes	11	3	6
642	N:N:P45	N:N:Q44	7.9	No	No	25	3	3
643	N:N:Q44	N:N:V94	5.73	No	No	0	3	3
644	N:N:M95	N:N:Q44	9.52	No	No	25	3	3
645	N:N:M95	N:N:P45	3.35	No	No	25	3	3
646	H:H:?5	N:N:P48	4.42	Yes	No	0	0	6
647	N:N:I49	N:N:V92	3.07	No	No	0	5	4
648	N:N:I49	N:N:N102	5.66	No	No	26	5	9
649	H:H:?5	N:N:I49	3.84	Yes	No	26	0	5
650	H:H:?5	N:N:L50	3.73	Yes	No	0	0	5
651	N:N:M53	N:N:Q51	5.44	Yes	No	24	4	9
652	L:L:R54	N:N:Q51	9.35	No	No	24	5	9
653	N:N:C52	N:N:C84	5.46	No	Yes	0	9	9
654	N:N:C106	N:N:C52	7.28	No	No	0	9	9
655	L:L:D55	N:N:C52	3.11	No	No	0	7	9
656	L:L:M52	N:N:M53	7.22	No	Yes	0	1	4
657	L:L:R54	N:N:M53	11.17	No	Yes	24	5	4
658	L:L:M52	N:N:G54	3.49	No	No	0	1	9
659	L:L:Y50	N:N:C55	5.38	No	No	0	6	9
660	N:N:C56	N:N:T82	3.38	No	No	13	9	8
661	N:N:C108	N:N:C56	7.28	Yes	No	13	9	9
662	N:N:F57	N:N:R59	7.48	Yes	Yes	9	7	8
663	L:L:G49	N:N:F57	3.01	No	Yes	9	9	7
664	L:L:Y50	N:N:F57	8.25	No	Yes	9	6	7
665	L:L:V71	N:N:S58	4.85	Yes	No	0	6	9
666	L:L:C72	N:N:S58	3.44	No	No	0	9	9
667	N:N:R59	N:N:Y61	15.43	Yes	Yes	9	8	8
668	N:N:E80	N:N:R59	17.45	No	Yes	9	9	8
669	L:L:Y27	N:N:R59	10.29	Yes	Yes	9	6	8
670	L:L:I46	N:N:R59	3.76	No	Yes	9	9	8
671	N:N:T78	N:N:Y61	14.98	No	Yes	0	9	8
672	N:N:E80	N:N:Y61	12.35	No	Yes	9	9	8
673	L:L:Y27	N:N:Y61	2.98	Yes	Yes	9	6	8
674	L:L:I46	N:N:Y61	3.63	No	Yes	9	9	8
675	L:L:M29	N:N:P62	5.03	Yes	No	0	7	9
676	L:L:Y97	N:N:P62	4.17	Yes	No	0	6	9
677	L:L:P98	N:N:P62	5.84	No	No	0	9	9
678	N:N:K68	N:N:T63	4.5	No	No	0	6	9
679	L:L:T122	N:N:P64	5.25	No	No	0	4	9
680	L:L:R33	N:N:L65	9.72	No	No	0	6	6
681	L:L:F95	N:N:L65	9.74	No	No	0	7	6
682	N:N:K68	N:N:Q74	4.07	No	No	0	6	7
683	L:L:D114	N:N:M71	5.54	Yes	No	1	9	9
684	L:L:Y79	N:N:N76	4.65	Yes	No	14	8	9
685	H:H:?6	N:N:N76	25.87	No	No	14	0	9
686	L:L:Y74	N:N:V77	5.05	Yes	No	0	8	9
687	L:L:I116	N:N:T78	6.08	Yes	No	0	7	9
688	N:N:S79	N:N:S81	4.89	Yes	No	1	9	9
689	L:L:V71	N:N:S79	3.23	Yes	Yes	1	6	9
690	L:L:C108	N:N:S79	5.16	Yes	Yes	1	9	9
691	L:L:C115	N:N:S79	3.44	Yes	Yes	1	9	9
692	L:L:A119	N:N:E80	4.53	No	No	0	5	9
693	L:L:V71	N:N:S81	8.08	Yes	No	1	6	9
694	N:N:C108	N:N:T82	3.38	Yes	No	13	9	8
695	N:N:C111	N:N:C83	7.28	No	No	1	9	9
696	L:L:T53	N:N:C83	6.76	No	No	0	9	9
697	L:L:Q69	N:N:C83	12.21	No	No	1	9	9
698	N:N:C108	N:N:C84	3.64	Yes	Yes	13	9	9
699	L:L:T53	N:N:C84	3.38	No	Yes	0	9	9
700	N:N:A86	N:N:H103	8.78	No	No	0	9	9
701	N:N:S88	N:N:T104	4.8	No	No	0	4	9
702	N:N:A105	N:N:S88	3.42	No	No	0	4	4
703	N:N:E101	N:N:Y89	4.49	No	No	0	5	4
704	N:N:R91	N:N:T93	3.88	No	No	0	4	3
705	N:N:K99	N:N:R91	19.8	No	No	0	3	4
706	N:N:V100	N:N:V92	6.41	No	No	0	5	4
707	N:N:V100	N:N:V94	6.41	No	No	0	5	3
708	N:N:E101	N:N:K99	8.1	No	No	0	5	3
709	L:L:N57	N:N:V100	5.91	Yes	No	0	7	5
710	H:H:?5	N:N:N102	23.41	Yes	No	26	0	9
711	L:L:D55	N:N:H103	7.56	No	No	0	7	9
712	L:L:N57	N:N:H103	14.03	Yes	No	0	7	9
713	H:H:?5	N:N:T104	3.97	Yes	No	0	0	9
714	N:N:S109	N:N:T110	4.8	No	No	0	8	9
715	N:N:T110	N:N:Y112	8.74	No	Yes	0	9	5
716	L:L:H117	N:N:T110	6.85	No	No	0	5	9
717	N:N:C111	N:N:H114	5.9	No	Yes	1	9	8
718	L:L:Q69	N:N:C111	4.58	No	No	1	9	9
719	N:N:Y112	N:N:Y113	3.97	Yes	Yes	0	5	4
720	L:L:L67	N:N:Y113	7.03	No	Yes	0	4	4
721	L:L:Q69	N:N:Y113	6.76	No	Yes	0	9	4
722	N:N:H114	N:N:K115	5.24	Yes	Yes	1	8	9
723	L:L:V71	N:N:H114	8.3	Yes	Yes	1	6	8
724	L:L:C108	N:N:H114	4.42	Yes	Yes	1	9	8
725	L:L:C115	N:N:H114	4.42	Yes	Yes	1	9	8
726	L:L:T110	N:N:K115	4.5	No	Yes	0	7	9
727	L:L:C115	N:N:K115	6.47	Yes	Yes	1	9	9
728	L:L:K107	N:N:S116	9.18	No	No	0	4	9
729	L:L:C22	L:L:C72	7.28	No	No	0	9	9
730	L:L:C105	L:L:C22	3.64	No	No	0	9	9
731	L:L:I23	L:L:T25	3.04	No	No	0	4	5
732	L:L:C103	L:L:P24	3.77	No	No	0	9	7
733	L:L:A48	L:L:T25	5.03	No	No	0	8	5
734	H:H:?7	L:L:E26	10.7	No	No	0	0	9
735	L:L:M29	L:L:Y27	4.79	Yes	Yes	0	7	6
736	L:L:I46	L:L:Y27	7.25	No	Yes	9	9	6
737	L:L:H30	L:L:T28	6.85	Yes	No	28	6	8
738	L:L:T28	L:L:T41	3.14	No	No	28	8	7
739	L:L:I42	L:L:M29	4.37	Yes	Yes	0	7	7
740	L:L:M29	L:L:T44	3.01	Yes	No	0	7	9
741	L:L:H30	L:L:T41	10.95	Yes	No	28	6	7
742	L:L:H30	L:L:N123	7.65	Yes	No	0	6	5
743	L:L:I31	L:L:I84	2.94	No	Yes	0	7	6
744	L:L:F95	L:L:I31	13.82	No	No	0	7	7
745	L:L:C39	L:L:E32	6.08	No	No	0	9	9
746	L:L:C36	L:L:R33	4.18	No	No	0	9	6
747	L:L:E35	L:L:R34	9.3	No	No	0	6	4
748	L:L:E35	L:L:P88	4.72	No	No	30	6	5
749	L:L:E35	L:L:H90	4.92	No	No	30	6	5
750	L:L:C36	L:L:I84	4.91	No	Yes	29	9	6
751	L:L:C36	L:L:C87	7.28	No	Yes	29	9	9
752	L:L:A37	L:L:Y38	5.34	No	No	0	5	4
753	L:L:C125	L:L:C39	7.28	No	No	0	9	9
754	L:L:I42	L:L:V82	3.07	Yes	No	27	7	5
755	L:L:I42	L:L:Y97	7.25	Yes	Yes	27	7	6
756	H:H:?7	L:L:N43	33.27	No	No	0	0	8
757	L:L:T44	L:L:V99	3.17	No	Yes	0	9	8
758	L:L:T45	L:L:V99	3.17	No	Yes	0	8	8
759	L:L:C103	L:L:C47	7.28	No	No	0	9	9
760	L:L:G49	L:L:Y50	5.79	No	No	9	9	6
761	L:L:C105	L:L:C51	7.28	No	No	0	9	9
762	L:L:I56	L:L:L62	4.28	No	Yes	11	5	3
763	L:L:F61	L:L:G58	6.02	No	No	11	3	2
764	L:L:K59	L:L:L67	5.64	No	No	0	5	4
765	L:L:P63	L:L:Y65	12.52	No	Yes	0	4	4
766	L:L:A66	L:L:P63	3.74	No	No	0	4	4
767	L:L:K107	L:L:S68	6.12	No	No	0	4	3
768	L:L:C105	L:L:D70	3.11	No	No	0	9	4
769	L:L:D70	L:L:G106	5.03	No	No	0	4	5
770	L:L:K104	L:L:T73	3	No	No	0	5	8
771	L:L:F77	L:L:Y74	13.41	Yes	Yes	0	4	8
772	L:L:A100	L:L:Y74	5.34	No	Yes	0	9	8
773	L:L:R75	L:L:S102	7.91	No	No	0	3	8
774	L:L:K104	L:L:R75	14.85	No	No	0	5	3
775	L:L:D76	L:L:L101	4.07	No	No	0	4	5
776	L:L:F77	L:L:Y79	6.19	Yes	Yes	14	4	8
777	L:L:F77	L:L:P98	4.33	Yes	No	14	4	9
778	L:L:F77	L:L:Y112	9.28	Yes	No	0	4	5
779	L:L:I78	L:L:L101	5.71	No	No	0	5	5
780	L:L:P98	L:L:Y79	5.56	No	Yes	14	9	8
781	H:H:?6	L:L:Y79	30.5	No	Yes	14	0	8
782	L:L:R80	L:L:Y97	9.26	No	Yes	0	5	6
783	L:L:R80	L:L:V99	13.08	No	Yes	0	5	8
784	L:L:T81	L:L:Y94	3.75	No	No	0	8	3
785	L:L:S96	L:L:T81	7.99	No	No	0	7	8
786	L:L:V82	L:L:Y97	5.05	No	Yes	27	5	6
787	L:L:I84	L:L:P85	3.39	Yes	No	0	6	8
788	L:L:C87	L:L:I84	3.27	Yes	Yes	29	9	6
789	L:L:C87	L:L:V91	5.12	Yes	No	0	9	7
790	L:L:C87	L:L:P93	3.77	Yes	No	0	9	7
791	L:L:H90	L:L:P88	9.15	No	No	30	5	5
792	L:L:P88	L:L:V91	7.07	No	No	0	5	7
793	L:L:A92	L:L:Y94	6.67	No	No	0	6	3
794	L:L:P93	L:L:Y94	6.95	No	No	0	7	3
795	L:L:F95	L:L:Y97	10.32	No	Yes	0	7	6
796	L:L:C108	L:L:S113	3.44	Yes	No	0	9	7
797	L:L:C108	L:L:C115	7.28	Yes	Yes	1	9	9
798	L:L:D111	L:L:N109	12.12	No	No	0	6	5
799	L:L:N109	L:L:Y112	15.12	No	No	0	5	5
800	H:H:?6	L:L:Y112	3.16	No	No	0	0	5
801	L:L:D114	L:L:I116	5.6	Yes	Yes	1	9	7
802	L:L:A119	L:L:I116	3.25	No	Yes	0	5	7
803	L:L:E118	L:L:H117	6.15	No	No	0	5	5
804	L:L:I120	L:L:T122	4.56	Yes	No	0	3	4
805	R:R:I60	R:R:K42	2.91	Yes	No	0	4	2
806	R:R:G174	R:R:Y148	2.9	No	No	0	9	4
807	R:R:G222	R:R:Y195	2.9	No	Yes	0	3	4
808	R:R:Q193	R:R:V169	2.87	No	No	0	5	5
809	R:R:E34	R:R:V39	2.85	No	Yes	0	4	6
810	R:R:I560	R:R:L578	2.85	No	No	0	7	3
811	R:R:I635	R:R:L669	2.85	No	No	0	6	8
812	L:L:I31	L:L:L40	2.85	No	No	0	7	7
813	L:L:I42	L:L:L40	2.85	Yes	No	0	7	7
814	L:L:L60	N:N:K99	2.82	No	No	0	3	3
815	N:N:K68	N:N:N76	2.8	No	No	0	6	9
816	R:R:H70	R:R:S73	2.79	Yes	No	0	4	4
817	L:L:P85	L:L:Y38	2.78	No	No	0	8	4
818	R:R:L114	R:R:L89	2.77	Yes	No	0	8	8
819	R:R:A196	R:R:F197	2.77	No	Yes	0	9	9
820	R:R:L231	R:R:L249	2.77	No	No	0	7	8
821	R:R:L241	R:R:L252	2.77	Yes	No	0	9	9
822	R:R:L246	R:R:L249	2.77	Yes	No	0	7	8
823	R:R:L252	R:R:L277	2.77	No	No	0	9	9
824	R:R:D487	R:R:K261	2.77	No	No	0	6	8
825	R:R:A285	R:R:F286	2.77	No	Yes	0	8	8
826	R:R:L587	R:R:L645	2.77	No	No	0	8	7
827	L:L:A48	N:N:F57	2.77	No	Yes	0	8	7
828	R:R:L75	R:R:N74	2.75	No	No	0	6	4
829	R:R:H63	R:R:T88	2.74	No	No	0	4	4
830	R:R:H105	R:R:T104	2.74	Yes	No	0	7	5
831	N:N:N102	N:N:N90	2.72	No	No	0	9	4
832	R:R:K209	R:R:Q235	2.71	Yes	No	0	7	4
833	H:H:?3	R:R:S101	2.69	No	No	0	0	4
834	L:L:C47	L:L:Y74	2.69	No	Yes	0	9	8
835	R:R:A623	R:R:Y605	2.67	No	No	0	9	9
836	L:L:Y74	N:N:A60	2.67	Yes	No	0	8	9
837	R:R:L270	R:R:Q289	2.66	No	No	0	3	7
838	R:R:E506	R:R:L589	2.65	Yes	No	0	8	3
839	R:R:N113	R:R:Q90	2.64	No	No	0	4	4
840	R:R:F269	R:R:S266	2.64	Yes	No	0	7	5
841	R:R:N406	R:R:Q489	2.64	No	No	0	9	9
842	L:L:N57	N:N:E101	2.63	Yes	No	0	7	5
843	R:R:F461	R:R:V433	2.62	No	No	0	5	3
844	R:R:F690	R:R:V689	2.62	No	Yes	0	5	5
845	N:N:H107	N:N:K87	2.62	No	No	0	8	5
846	R:R:D36	R:R:E35	2.6	No	No	0	3	1
847	R:R:R65	R:R:T88	2.59	No	No	0	4	4
848	R:R:F500	R:R:T496	2.59	No	No	0	7	5
849	R:R:Q90	R:R:Q91	2.56	No	Yes	0	4	3
850	L:L:Y65	R:R:S229	2.54	Yes	No	0	4	5
851	R:R:F423	R:R:I419	2.51	No	No	0	5	6
852	R:R:H63	R:R:Q45	2.47	No	No	0	4	4
853	R:R:F676	R:R:L427	2.44	No	No	0	8	7
854	R:R:M453	R:R:Y678	2.39	No	Yes	0	7	9
855	R:R:F681	R:R:Q686	2.34	No	No	0	8	7
856	L:L:N123	L:L:Y27	2.33	No	Yes	0	5	6
857	R:R:K603	R:R:W520	2.32	No	Yes	0	7	7
858	R:R:Q91	R:R:Y116	2.25	Yes	Yes	5	3	3
859	R:R:G544	R:R:G545	2.11	No	No	0	3	9
860	N:N:G96	N:N:G97	2.11	No	No	0	3	4
861	R:R:G431	R:R:P675	2.03	No	No	0	9	9
862	R:R:C390	R:R:G391	1.96	No	No	0	9	5
863	R:R:P51	R:R:P52	1.95	Yes	No	0	5	3
864	R:R:P52	R:R:P76	1.95	No	No	0	3	5
865	L:L:A37	L:L:G86	1.95	No	No	0	5	7
866	N:N:A47	N:N:P48	1.87	No	No	0	5	6
867	R:R:G491	R:R:T490	1.82	No	No	0	8	8
868	L:L:G106	L:L:T73	1.82	No	No	0	5	8
869	R:R:A275	R:R:C398	1.81	No	No	0	9	9
870	R:R:A504	R:R:C462	1.81	No	No	0	8	7
871	R:R:P51	R:R:S53	1.78	Yes	No	0	5	5
872	R:R:P280	R:R:S402	1.78	No	No	0	8	9
873	R:R:G391	R:R:I389	1.76	No	No	0	5	4
874	R:R:P126	R:R:T150	1.75	No	No	0	5	3
875	R:R:P400	R:R:T399	1.75	No	No	0	9	4
876	R:R:A121	R:R:S96	1.71	No	No	0	9	7
877	R:R:A579	R:R:S561	1.71	No	No	0	8	9
878	R:R:C599	R:R:V595	1.71	No	No	0	4	3
879	R:R:G188	R:R:N187	1.7	No	Yes	0	6	9
880	R:R:A254	R:R:V233	1.7	No	Yes	0	8	7
881	R:R:A593	R:R:V509	1.7	No	No	0	9	8
882	R:R:D219	R:R:G194	1.68	No	No	0	3	3
883	R:R:L127	R:R:P126	1.64	No	No	0	4	5
884	R:R:N77	R:R:P76	1.63	No	No	0	8	5
885	R:R:S166	R:R:S191	1.63	No	No	0	5	4
886	R:R:C408	R:R:K287	1.62	No	No	0	9	5
887	N:N:S109	N:N:V85	1.62	No	No	0	8	9
888	N:N:A105	N:N:K87	1.61	No	No	0	4	5
889	R:R:S191	R:R:T190	1.6	No	No	0	4	5
890	R:R:S237	R:R:T214	1.6	No	No	0	4	4
891	R:R:T88	R:R:V87	1.59	No	No	0	4	4
892	R:R:T214	R:R:V215	1.59	No	No	0	4	2
893	R:R:T399	R:R:V397	1.59	No	No	0	4	2
894	R:R:T588	R:R:V584	1.59	No	No	0	3	5
895	R:R:A673	R:R:L669	1.58	No	No	0	9	8
896	R:R:T239	R:R:T259	1.57	No	No	0	4	5
897	R:R:I648	R:R:V584	1.54	Yes	No	0	6	5
898	R:R:I606	R:R:V602	1.54	No	No	0	3	4
899	L:L:I78	L:L:V99	1.54	No	Yes	0	5	8
900	R:R:K244	R:R:S243	1.53	No	No	0	3	5
901	R:R:M637	R:R:S641	1.53	No	No	0	7	9
902	R:R:K695	R:R:S694	1.53	No	No	0	8	8
903	R:R:I486	R:R:T490	1.52	Yes	No	0	8	8
904	R:R:I583	R:R:T574	1.52	No	No	3	7	6
905	R:R:I648	R:R:T574	1.52	Yes	No	3	6	6
906	R:R:F221	R:R:G245	1.51	Yes	No	0	9	9
907	N:N:F98	N:N:G97	1.51	No	No	0	3	4
908	R:R:K624	R:R:T620	1.5	No	No	0	9	7
909	R:R:L551	R:R:V547	1.49	No	No	0	2	3
910	L:L:C125	L:L:H30	1.47	No	Yes	0	9	6
911	L:L:N43	L:L:T28	1.46	No	No	0	8	8
912	R:R:I606	R:R:K603	1.45	No	No	0	3	7
913	R:R:I438	R:R:L692	1.43	Yes	No	0	8	8
914	R:R:I648	R:R:L649	1.43	Yes	No	0	6	5
915	R:R:I691	R:R:L692	1.43	No	No	0	6	8
916	R:R:K211	R:R:N186	1.4	No	No	0	3	7
917	R:R:L426	R:R:L429	1.38	No	Yes	0	6	7
918	R:R:L554	R:R:L557	1.38	No	No	0	5	7
919	R:R:A684	R:R:R687	1.38	No	No	0	8	7
920	R:R:E61	R:R:I60	1.37	No	Yes	0	5	4
921	L:L:L62	R:R:D382	1.36	Yes	No	0	3	4
922	R:R:D619	R:R:N610	1.35	No	No	0	9	6
923	R:R:F550	R:R:L551	1.22	No	No	0	4	2
924	R:R:K139	R:R:Y163	1.19	No	No	0	4	4
925	R:R:L265	R:R:Y482	1.17	No	Yes	0	7	8

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	R:R:V39	4.61	5	6	6
2	R:R:L50	4.52167	6	6	5
3	R:R:P51	3.4775	4	0	5
4	R:R:L57	3.765	4	6	7
5	R:R:I60	4.114	5	17	4
6	R:R:I67	4.155	6	6	5
7	R:R:H70	4.625	4	5	4
8	R:R:F72	4.62167	6	6	9
9	R:R:I78	4.555	4	6	7
10	R:R:I81	5.09	4	6	8
11	R:R:Y82	10.2375	4	1	4
12	R:R:I85	3.7125	4	0	6
13	R:R:Q91	6.23	4	5	3
14	R:R:H95	8.1125	4	5	5
15	R:R:F97	5.26833	6	6	9
16	R:R:Y98	8.652	5	5	2
17	R:R:L100	4.3525	4	6	8
18	R:R:H105	8.976	5	1	7
19	R:R:R109	10.832	5	1	5
20	R:R:N110	6.146	5	1	6
21	R:R:L114	4.68	4	2	8
22	R:R:Y116	5.4025	4	5	3
23	R:R:D118	7.8875	4	5	5
24	R:R:F130	7.75333	6	1	6
25	R:R:F134	7.955	6	1	5
26	R:R:N135	5.6025	4	1	8
27	R:R:T136	5.31833	6	2	9
28	R:R:L138	5	4	2	8
29	R:R:F141	5.95167	6	2	7
30	R:R:K146	6.612	5	5	4
31	R:R:F153	11.2825	4	0	5
32	R:R:F154	5.93	6	2	6
33	R:R:L156	4.3725	4	2	7
34	R:R:E157	8.34167	6	1	8
35	R:R:T159	6.25	4	1	5
36	R:R:D160	5.566	5	1	8
37	R:R:M164	4.88	5	2	7
38	R:R:N170	10.165	4	10	8
39	R:R:F172	5.99833	6	2	8
40	R:R:Q173	8.46	4	10	2
41	R:R:L175	6.752	5	2	7
42	R:R:E178	8	4	2	5
43	R:R:L180	3.725	4	2	7
44	R:R:L182	5.82	5	2	6
45	R:R:K183	6.7725	4	1	6
46	R:R:Y185	8.035	4	1	7
47	R:R:N187	6.512	5	2	9
48	R:R:F189	8.474	5	2	8
49	R:R:Y195	5.4025	4	10	4
50	R:R:F197	6.695	4	0	9
51	R:R:N198	9.786	5	10	7
52	R:R:T200	5.11	4	2	8
53	R:R:L202	5.302	5	2	8
54	R:R:V205	3.742	5	2	7
55	R:R:Y206	4.804	5	1	6
56	R:R:N208	6.816	5	1	5
57	R:R:K209	4.49833	6	0	7
58	R:R:F221	6.8275	4	2	9
59	R:R:P228	4.998	5	2	8
60	R:R:L230	6.062	5	1	4
61	R:R:D232	10.4775	4	1	9
62	R:R:V233	3.09	4	19	7
63	R:R:S234	4.3475	4	1	9
64	R:R:L241	3.786	5	19	9
65	R:R:L246	4.2675	4	2	7
66	R:R:I253	6.778	5	1	4
67	R:R:R255	4.8425	4	1	4
68	R:R:P264	4.47	5	0	9
69	R:R:F269	4.545	4	15	7
70	R:R:R274	9.135	4	1	3
71	R:R:Y279	7.468	5	12	9
72	R:R:F286	4.56667	6	15	8
73	R:R:F405	7.7225	4	3	8
74	R:R:E409	8.23	4	20	9
75	R:R:I411	4.392	5	8	8
76	R:R:Y414	5.8625	4	22	4
77	R:R:V421	4.3175	4	0	9
78	R:R:L429	3.15	4	0	7
79	R:R:V435	3.954	5	7	9
80	R:R:I438	5.835	4	7	8
81	R:R:L439	4.0625	4	7	8
82	R:R:V448	4.056	5	4	9
83	R:R:R450	5.61	4	0	9
84	R:R:F451	5.478	5	4	9
85	R:R:L456	5.94833	6	4	9
86	R:R:D460	6.378	5	4	9
87	R:R:M463	5.378	5	3	9
88	R:R:Y466	6.034	5	3	9
89	R:R:L467	3.734	5	3	9
90	R:R:Y481	5.53667	6	8	8
91	R:R:Y482	5.2925	4	0	8
92	R:R:I486	6.62	4	12	8
93	R:R:W488	6.366	5	8	9
94	R:R:T501	4.45	5	0	9
95	R:R:V502	3.786	5	3	9
96	R:R:E506	6.012	5	3	8
97	R:R:L507	5.6725	4	0	9
98	R:R:T511	3.725	4	4	9
99	R:R:W520	5.17	4	0	7
100	R:R:M542	4.834	5	4	9
101	R:R:W546	6.484	5	4	9
102	R:R:Y563	9.026	5	3	9
103	R:R:I568	5.07	4	3	9
104	R:R:L570	6.074	5	3	9
105	R:R:M572	7.37	4	3	9
106	R:R:Y582	5.35167	6	3	9
107	R:R:V586	5.1025	4	3	7
108	R:R:F594	7.875	4	0	8
109	R:R:Y601	6.72667	6	4	9
110	R:R:D633	5.2875	4	0	8
111	R:R:Y643	7.9475	4	0	8
112	R:R:I648	2.584	5	3	6
113	R:R:L663	5.1675	4	3	9
114	R:R:Y667	5.63167	6	3	9
115	R:R:P668	4.69	4	3	9
116	R:R:N674	7.965	4	4	9
117	R:R:Y678	4.97143	7	4	9
118	R:R:F685	5.58667	6	7	9
119	R:R:V689	3.15	4	7	5
120	N:N:F42	8.83	5	11	6
121	N:N:M53	6.9775	4	24	4
122	N:N:F57	5.3775	4	9	7
123	N:N:R59	10.882	5	9	8
124	N:N:Y61	9.874	5	9	8
125	N:N:S79	4.18	4	1	9
126	N:N:C84	4.485	4	13	9
127	N:N:C108	5.395	4	13	9
128	N:N:Y112	8.45	4	1	5
129	N:N:Y113	5.4725	4	0	4
130	N:N:H114	5.656	5	1	8
131	N:N:K115	6.415	4	1	9
132	L:L:Y27	5.528	5	9	6
133	L:L:M29	4.3	4	0	7
134	L:L:H30	6.73	4	28	6
135	L:L:I42	4.385	4	27	7
136	L:L:N57	6.5475	4	0	7
137	L:L:L62	3.5175	4	11	3
138	L:L:Y65	8.85	5	1	4
139	L:L:V71	6.115	4	1	6
140	L:L:Y74	5.832	5	0	8
141	L:L:F77	8.3025	4	14	4
142	L:L:Y79	11.725	4	14	8
143	L:L:I84	3.6275	4	29	6
144	L:L:C87	4.86	4	29	9
145	L:L:Y97	7.21	5	27	6
146	L:L:V99	5.24	4	0	8
147	L:L:C108	5.075	4	1	9
148	L:L:D114	6.2175	4	1	9
149	L:L:C115	5.4025	4	1	9
150	L:L:I116	4.985	4	1	7
151	L:L:I120	5.2425	4	17	3
152	W:W:?1	6.96714	14	3	0
153	H:H:?1	12.978	5	10	0
154	H:H:?5	7.874	5	26	0

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:C176	R:R:F154	99.9637	8.38	No	Yes	2	6	6
2	R:R:C176	R:R:E178	100	3.04	No	Yes	2	6	5
3	R:R:E178	R:R:I152	98.8633	9.56	Yes	No	0	5	3
4	R:R:F153	R:R:I152	98.7361	5.02	Yes	No	0	5	3
5	N:N:Y113	R:R:F153	67.814	4.13	Yes	Yes	0	4	5
6	N:N:Y112	N:N:Y113	46.9287	3.97	Yes	Yes	0	5	4
7	N:N:Y112	R:R:F130	40.5573	12.38	Yes	Yes	1	5	6
8	R:R:F130	R:R:F134	27.2028	3.22	Yes	Yes	1	6	5
9	R:R:F134	R:R:R109	26.6131	14.97	Yes	Yes	1	5	5
10	L:L:I116	R:R:R109	17.3114	5.01	Yes	Yes	1	7	5
11	R:R:E157	R:R:F130	13.676	4.66	Yes	Yes	1	8	6
12	L:L:K64	R:R:F153	31.5643	22.33	No	Yes	0	5	5
13	L:L:K64	R:R:D203	23.3263	20.74	No	No	18	5	6
14	R:R:D203	R:R:T181	25.1368	4.34	No	No	0	6	7
15	R:R:L156	R:R:L182	50.1347	4.15	Yes	Yes	2	7	6
16	R:R:L180	R:R:L182	50.0528	4.15	Yes	Yes	2	7	6
17	R:R:K183	R:R:T181	24.1509	3	Yes	No	0	6	7
18	N:N:C111	N:N:H114	10.1306	5.9	No	Yes	1	9	8
19	L:L:Q69	N:N:Y113	22.7653	6.76	No	Yes	0	9	4
20	R:R:L182	R:R:V205	95.2415	4.47	Yes	Yes	2	6	7
21	R:R:K183	R:R:Y206	17.3	3.58	Yes	Yes	1	6	6
22	R:R:N208	R:R:Y185	12.8014	5.81	Yes	Yes	1	5	7
23	R:R:K209	R:R:N208	13.82	6.99	Yes	Yes	0	7	5
24	R:R:L231	R:R:V205	94.4273	2.98	No	Yes	0	7	7
25	L:L:D111	R:R:K209	18.272	5.53	No	Yes	0	6	7
26	R:R:L231	R:R:V233	94.8612	4.47	No	Yes	0	7	7
27	R:R:L241	R:R:V233	94.4179	2.98	Yes	Yes	19	9	7
28	R:R:L241	R:R:P264	50.6393	3.28	Yes	Yes	0	9	9
29	R:R:L263	R:R:P264	48.1078	3.28	No	Yes	0	8	9
30	R:R:H282	R:R:L263	46.7986	6.43	No	No	0	9	8
31	R:R:H282	R:R:Y279	93.0208	6.53	No	Yes	0	9	9
32	R:R:L241	R:R:L252	46.8879	2.77	Yes	No	0	9	9
33	R:R:L252	R:R:L277	46.7994	2.77	No	No	0	9	9
34	R:R:H282	R:R:L277	46.4402	3.86	No	No	0	9	9
35	R:R:I486	R:R:Y279	91.395	13.3	Yes	Yes	12	8	9
36	R:R:A485	R:R:I281	90.6143	3.25	No	No	0	9	9
37	R:R:I281	R:R:I486	90.8336	2.94	No	Yes	0	9	8
38	L:L:N57	N:N:H103	12.8592	14.03	Yes	No	0	7	9
39	L:L:D55	N:N:H103	13.299	7.56	No	No	0	7	9
40	L:L:D55	N:N:C52	13.5186	3.11	No	No	0	7	9
41	N:N:C52	N:N:C84	14.1763	5.46	No	Yes	0	9	9
42	L:L:T53	N:N:C84	15.2687	3.38	No	Yes	0	9	9
43	L:L:T53	N:N:C83	15.4866	6.76	No	No	0	9	9
44	L:L:Q69	N:N:C83	13.9901	12.21	No	No	1	9	9
45	R:R:A485	R:R:Y481	90.3948	6.67	No	Yes	0	9	8
46	R:R:S567	R:R:Y481	19.16	5.09	No	Yes	8	9	8
47	R:R:K660	R:R:S567	18.9598	3.06	No	No	0	9	9
48	R:R:I568	R:R:K660	16.3881	4.36	Yes	No	0	9	9
49	R:R:I568	R:R:L570	13.1257	5.71	Yes	Yes	3	9	9
50	R:R:L570	W:W:?1	11.5418	13.32	Yes	Yes	3	9	0
51	R:R:I411	R:R:Y481	67.4397	7.25	Yes	Yes	8	8	8
52	R:R:I411	R:R:I470	63.3003	2.94	Yes	No	0	8	8
53	R:R:I470	R:R:Y466	63.0766	8.46	No	Yes	0	8	9
54	R:R:M463	R:R:Y466	50.1942	3.59	Yes	Yes	3	9	9
55	R:R:M463	R:R:S671	50.2395	6.13	Yes	No	0	9	9
56	R:R:D460	R:R:S671	49.7303	4.42	Yes	No	0	9	9
57	R:R:D460	R:R:L456	24.7494	5.43	Yes	Yes	4	9	9
58	R:R:D460	R:R:N674	15.5724	9.42	Yes	Yes	4	9	9
59	R:R:L456	R:R:Y678	10.7258	3.52	Yes	Yes	4	9	9
60	R:R:N674	R:R:Y678	10.3804	4.65	Yes	Yes	4	9	9
61	R:R:Y601	R:R:Y678	17.2363	2.98	Yes	Yes	4	9	9
62	R:R:T516	R:R:Y601	11.7084	12.48	No	Yes	0	9	9
63	R:R:C600	R:R:T516	11.1778	3.38	No	No	0	9	9
64	N:N:T78	N:N:Y61	14.4582	14.98	No	Yes	0	9	8
65	L:L:I116	N:N:T78	14.6826	6.08	Yes	No	0	7	9
66	L:L:Y27	N:N:Y61	11.4675	2.98	Yes	Yes	9	6	8
67	L:L:N109	L:L:Y112	16.4063	15.12	No	No	0	5	5
68	L:L:D111	L:L:N109	17.3384	12.12	No	No	0	6	5
69	R:R:F154	R:R:L156	46.837	3.65	Yes	Yes	2	6	7
70	R:R:F154	R:R:L180	50.8013	3.65	Yes	Yes	2	6	7

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:E35	R:R:R38	4.65	0	No	No	1	4	2	1
R:R:R38	R:R:T56	6.47	0	No	No	4	5	1	2
L:L:E118	R:R:R38	10.47	0	No	No	5	4	0	1
L:L:Y124	R:R:K42	4.78	0	No	No	4	2	0	1
R:R:R80	R:R:T56	7.76	1	No	No	4	5	2	2
R:R:I60	R:R:K58	4.36	17	Yes	No	4	5	1	2
R:R:K58	R:R:Y82	9.55	0	No	Yes	5	4	2	2
R:R:I60	R:R:S84	3.1	17	Yes	No	4	7	1	1
L:L:I120	R:R:I60	8.83	17	Yes	Yes	3	4	0	1
N:N:R66	R:R:E61	3.49	0	No	No	6	5	0	1
R:R:R80	R:R:Y82	8.23	1	No	Yes	4	4	2	2
R:R:H105	R:R:R80	3.39	1	Yes	No	7	4	1	2
R:R:H105	R:R:Y82	13.07	1	Yes	Yes	7	4	1	2
R:R:E107	R:R:Y82	10.1	1	No	Yes	6	4	2	2
L:L:I120	R:R:S84	4.64	17	Yes	No	3	7	0	1
R:R:I85	R:R:N110	4.25	0	Yes	Yes	6	6	1	1
N:N:S67	R:R:I85	3.1	0	No	Yes	7	6	0	1
N:N:T70	R:R:I85	4.56	0	No	Yes	9	6	0	1
L:L:I120	R:R:I85	2.94	17	Yes	Yes	3	6	0	1
N:N:T70	R:R:V87	3.17	0	No	No	9	4	0	1
R:R:F130	R:R:H105	16.97	1	Yes	Yes	6	7	1	1
N:N:Y112	R:R:H105	8.71	1	Yes	Yes	5	7	0	1
R:R:E107	R:R:R109	18.61	1	No	Yes	6	5	2	1
R:R:E107	R:R:F134	7	1	No	Yes	6	5	2	2
R:R:N110	R:R:R109	7.23	1	Yes	Yes	6	5	1	1
R:R:F134	R:R:R109	14.97	1	Yes	Yes	5	5	2	1
L:L:D114	R:R:R109	8.34	1	Yes	Yes	9	5	0	1
L:L:I116	R:R:R109	5.01	1	Yes	Yes	7	5	0	1
R:R:N110	R:R:N135	5.45	1	Yes	Yes	6	8	1	1
N:N:M71	R:R:N110	8.41	1	No	Yes	9	6	0	1
L:L:D114	R:R:N110	5.39	1	Yes	Yes	9	6	0	1
N:N:L72	R:R:R112	7.29	1	No	No	3	6	0	1
R:R:F130	R:R:G132	3.01	1	Yes	No	6	5	1	2
R:R:F130	R:R:F134	3.22	1	Yes	Yes	6	5	1	2
R:R:F130	R:R:I155	6.28	1	Yes	No	6	5	1	2
R:R:E157	R:R:F130	4.66	1	Yes	Yes	8	6	1	1
N:N:Y112	R:R:F130	12.38	1	Yes	Yes	5	6	0	1
R:R:F134	R:R:G132	4.52	1	Yes	No	5	5	2	2
R:R:E157	R:R:F134	12.83	1	Yes	Yes	8	5	1	2
R:R:F134	R:R:T159	5.19	1	Yes	Yes	5	5	2	2
R:R:D160	R:R:N135	4.04	1	Yes	Yes	8	8	1	1
N:N:M71	R:R:N135	7.01	1	No	Yes	9	8	0	1
N:N:V73	R:R:N135	5.91	1	No	Yes	7	8	0	1
R:R:F153	R:R:I152	5.02	0	Yes	No	5	3	1	2
N:N:Y113	R:R:F153	4.13	0	Yes	Yes	4	5	0	1
L:L:K59	R:R:F153	13.65	0	No	Yes	5	5	0	1
L:L:K64	R:R:F153	22.33	18	No	Yes	5	5	0	1
R:R:I155	R:R:T181	4.56	0	No	No	5	7	2	2
R:R:E157	R:R:T159	4.23	1	Yes	Yes	8	5	1	2
R:R:E157	R:R:K183	12.15	1	Yes	Yes	8	6	1	2
R:R:E157	R:R:Y185	6.73	1	Yes	Yes	8	7	1	2
N:N:K115	R:R:E157	9.45	1	Yes	Yes	9	8	0	1
R:R:D160	R:R:T159	4.34	1	Yes	Yes	8	5	1	2
R:R:T159	R:R:Y185	11.24	1	Yes	Yes	5	7	2	2
R:R:D160	R:R:N186	5.39	1	Yes	No	8	7	1	2
N:N:V73	R:R:D160	4.38	1	No	Yes	7	8	0	1
N:N:K75	R:R:D160	9.68	0	No	Yes	9	8	0	1
R:R:P162	R:R:Y163	6.95	1	No	No	7	4	1	1
N:N:L72	R:R:P162	8.21	1	No	No	3	7	0	1
N:N:V73	R:R:P162	5.3	1	No	No	7	7	0	1
N:N:L72	R:R:Y163	5.86	1	No	No	3	4	0	1
R:R:K201	R:R:T179	3	0	No	No	4	5	2	1
R:R:D203	R:R:T179	14.45	18	No	No	6	5	1	1
L:L:K64	R:R:T179	4.5	18	No	No	5	5	0	1
R:R:K183	R:R:T181	3	1	Yes	No	6	7	2	2
R:R:D203	R:R:T181	4.34	18	No	No	6	7	1	2
R:R:K183	R:R:Y185	8.36	1	Yes	Yes	6	7	2	2
R:R:K183	R:R:Y206	3.58	1	Yes	Yes	6	6	2	2
R:R:N208	R:R:Y185	5.81	1	Yes	Yes	5	7	2	2
R:R:K209	R:R:N186	4.2	0	Yes	No	7	7	1	2
L:L:K64	R:R:D203	20.74	18	No	No	5	6	0	1
R:R:A204	R:R:Y206	5.34	1	No	Yes	5	6	1	2
R:R:A204	R:R:L230	3.15	1	No	Yes	5	4	1	1
L:L:Y65	R:R:A204	4	1	Yes	No	4	5	0	1
R:R:N208	R:R:Y206	3.49	1	Yes	Yes	5	6	2	2
R:R:L230	R:R:Y206	5.86	1	Yes	Yes	4	6	1	2
R:R:K209	R:R:N208	6.99	0	Yes	Yes	7	5	1	2
N:N:S116	R:R:K209	3.06	0	No	Yes	9	7	0	1
L:L:T110	R:R:K209	4.5	0	No	Yes	7	7	0	1
L:L:D111	R:R:K209	5.53	0	No	Yes	6	7	0	1
R:R:E251	R:R:L230	5.3	1	No	Yes	5	4	1	1
R:R:I253	R:R:L230	4.28	1	Yes	Yes	4	4	2	1
L:L:Y65	R:R:L230	11.72	1	Yes	Yes	4	4	0	1
R:R:E251	R:R:R274	12.79	1	No	Yes	5	3	1	2
L:L:Y65	R:R:E251	13.47	1	Yes	No	4	5	0	1
R:R:I253	R:R:R274	6.26	1	Yes	Yes	4	3	2	2
N:N:F42	R:R:S383	5.28	11	Yes	No	6	4	0	1
L:L:I56	R:R:S383	4.64	11	No	No	5	4	0	1
L:L:L62	R:R:S383	3	11	Yes	No	3	4	0	1
N:N:F41	R:R:H384	5.66	0	No	No	1	3	0	1
R:R:D386	R:R:Y385	4.6	0	No	No	5	4	1	2
L:L:L62	R:R:D386	5.43	11	Yes	No	3	5	0	1
N:N:F41	R:R:Y387	16.5	0	No	No	1	4	0	1
N:N:F98	R:R:Y387	7.22	0	No	No	3	4	0	1
L:L:F61	R:R:Y387	29.91	11	No	No	3	4	0	1
N:N:F41	R:R:T388	7.78	0	No	No	1	4	0	1
H:H:?5	N:N:P48	4.42	26	Yes	No	0	6	1	0
H:H:?5	N:N:I49	3.84	26	Yes	No	0	5	1	0
H:H:?5	N:N:L50	3.73	26	Yes	No	0	5	1	0
H:H:?6	N:N:N76	25.87	14	No	No	0	9	1	0
H:H:?5	N:N:N102	23.41	26	Yes	No	0	9	1	0
H:H:?5	N:N:T104	3.97	26	Yes	No	0	9	1	0
H:H:?7	L:L:E26	10.7	0	No	No	0	9	1	0
H:H:?7	L:L:N43	33.27	0	No	No	0	8	1	0
H:H:?6	L:L:Y79	30.5	14	No	Yes	0	8	1	0
H:H:?6	L:L:Y112	3.16	14	No	No	0	5	1	0
R:R:I60	R:R:K42	2.91	17	Yes	No	4	2	1	1
R:R:H105	R:R:T104	2.74	1	Yes	No	7	5	1	2
R:R:K209	R:R:Q235	2.71	0	Yes	No	7	4	1	2
L:L:Y65	R:R:S229	2.54	1	Yes	No	4	5	0	1
R:R:T88	R:R:V87	1.59	0	No	No	4	4	2	1
R:R:E61	R:R:I60	1.37	0	No	Yes	5	4	1	1
L:L:L62	R:R:D382	1.36	11	Yes	No	3	4	0	1
R:R:K139	R:R:Y163	1.19	0	No	No	4	4	2	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:D403	R:R:F405	8.36	0	No	Yes	8	8	2	1
R:R:F405	R:R:K565	14.89	3	Yes	No	8	7	1	2
R:R:F405	R:R:M572	3.73	3	Yes	Yes	8	9	1	1
R:R:F405	W:W:?1	3.91	3	Yes	Yes	8	0	1	0
R:R:T501	R:R:V502	3.17	0	Yes	Yes	9	9	2	2
R:R:L570	R:R:T501	2.95	3	Yes	Yes	9	9	1	2
R:R:T501	R:R:Y667	3.75	0	Yes	Yes	9	9	2	2
R:R:V502	R:R:Y563	5.05	3	Yes	Yes	9	9	2	2
R:R:P571	R:R:V502	3.53	3	No	Yes	9	9	1	2
R:R:V502	R:R:Y582	3.79	3	Yes	Yes	9	9	2	2
R:R:E506	R:R:L552	3.98	3	Yes	No	8	7	2	2
R:R:E506	R:R:V586	8.56	3	Yes	Yes	8	7	2	1
R:R:L552	R:R:V586	2.98	3	No	Yes	7	7	2	1
R:R:P571	R:R:Y563	8.34	3	No	Yes	9	9	1	2
R:R:I568	R:R:V566	3.07	3	Yes	No	9	9	2	2
R:R:M572	R:R:V566	6.09	3	Yes	No	9	9	1	2
R:R:I568	R:R:L570	5.71	3	Yes	Yes	9	9	2	1
R:R:I568	R:R:L663	7.14	3	Yes	Yes	9	9	2	2
R:R:L570	R:R:M572	4.24	3	Yes	Yes	9	9	1	1
R:R:L570	R:R:L663	4.15	3	Yes	Yes	9	9	1	2
R:R:L570	W:W:?1	13.32	3	Yes	Yes	9	0	1	0
R:R:P571	W:W:?1	8.43	3	No	Yes	9	0	1	0
R:R:M572	W:W:?1	15.42	3	Yes	Yes	9	0	1	0
R:R:V586	R:R:Y582	5.05	3	Yes	Yes	7	9	1	2
R:R:I583	R:R:I648	2.94	3	No	Yes	7	6	1	1
R:R:I583	W:W:?1	7.33	3	No	Yes	7	0	1	0
R:R:V586	W:W:?1	3.82	3	Yes	Yes	7	0	1	0
R:R:A644	R:R:L587	4.73	3	No	No	9	8	1	1
R:R:L587	W:W:?1	7.99	3	No	Yes	8	0	1	0
R:R:I640	R:R:Y667	3.63	0	No	Yes	9	9	1	2
R:R:I640	W:W:?1	7.33	0	No	Yes	9	0	1	0
R:R:L662	R:R:Y643	5.86	0	No	Yes	8	8	1	2
R:R:A644	W:W:?1	5.05	3	No	Yes	9	0	1	0
R:R:A647	W:W:?1	6.07	0	No	Yes	9	0	1	0
R:R:I648	W:W:?1	5.49	3	Yes	Yes	6	0	1	0
R:R:P652	W:W:?1	3.16	0	No	Yes	9	0	1	0
R:R:S659	R:R:V656	3.23	0	No	No	9	7	1	2
R:R:S659	W:W:?1	5.78	0	No	Yes	9	0	1	0
R:R:L662	W:W:?1	4.44	0	No	Yes	8	0	1	0
R:R:L663	R:R:Y667	3.52	3	Yes	Yes	9	9	2	2
R:R:L587	R:R:L645	2.77	3	No	No	8	7	1	2
R:R:I648	R:R:V584	1.54	3	Yes	No	6	5	1	2
R:R:I583	R:R:T574	1.52	3	No	No	7	6	1	2
R:R:I648	R:R:T574	1.52	3	Yes	No	6	6	1	2
R:R:I648	R:R:L649	1.43	3	Yes	No	6	5	1	2

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	7XW5_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	2.94
Number of Linked Nodes	735
Number of Links	925
Number of Hubs	154
Number of Links mediated by Hubs	540
Number of Communities	30
Number of Nodes involved in Communities	252
Number of Links involved in Communities	358

Path Summary
Number Of Nodes in MetaPath	71
Number Of Links MetaPath	70
Number of Shortest Paths	1384830
Length Of Smallest Path	3
Average Path Length	31.0127
Length of Longest Path	56
Minimum Path Strength	1.355
Average Path Strength	5.85449
Maximum Path Strength	23.205
Minimum Path Correlation	0.7
Average Path Correlation	0.986024
Maximum Path Correlation	1
Minimum % Of Corr. Nodes	3.0303
Average % Of Corr. Nodes	50.4742
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	56.0633
Maximum Path Hubs %	100

Details about the values in these tables can be found in the corresponding documentation page .


Code	HOI
PDB Residues	W:W:?1
Environment Details	Open EMBL-EBI Page
Code	HOI
Name	~{N}-[4-[[2-methoxy-5-[(2~{S})-5-oxidanyl-4-oxidanylidene-3-(phenylmethyl)-1,2-dihydroquinazolin-2-yl]phenyl]methoxy]phenyl]ethanamide
Synonyms
Identifier
Formula	C31 H29 N3 O5
Molecular Weight	523.579
SMILES
PubChem	118685720
Formal Charge	0
Total Atoms	68
Total Chiral Atoms	1
Total Bonds	72
Total Aromatic Bonds	24


Code	NAG
PDB Residues	H:H:?1 H:H:?2 H:H:?3 H:H:?4 H:H:?5 H:H:?6 H:H:?7
Environment Details	Open EMBL-EBI Page
Code	NAG
Name	N-Acetylglucosamine
Synonyms	N-Acetylchitosamine
Identifier
Formula	C8 H15 N O6
Molecular Weight	221.208
SMILES
PubChem	24139
Formal Charge	0
Total Atoms	30
Total Chiral Atoms	5
Total Bonds	30
Total Aromatic Bonds	0


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P16473
Sequence	>7XW5_nogp_Chain_R E C H Q E E D F R V T C K D I Q R I P S L P P S T Q T L K L I E T H L R T I P S H A F S N L P N I S R I Y V S I D V T L Q Q L E S H S F Y N L S K V T H I E I R N T R N L T Y I D P D A L K E L P L L K F L G I F N T G L K M F P D L T K V Y S T D I F F I L E I T D N P Y M T S I P V N A F Q G L C N E T L T L K L Y N N G F T S V Q G Y A F N G T K L D A V Y L N K N K Y L T V I D K D A F G G V Y S G P S L L D V S Q T S V T A L P S K G L E H L K E L I A R N T W T L K K L P L S L S F L H L T R A D L S Y P I H C C A F K N Q K D S H Y D Y T I C G D S E D M V C T P K S D E F N P C E D I M G Y K F L R I V V W F V S L L A L L G N V F V L L I L L T S H Y K L N V P R F L M C N L A F A D F C M G M Y L L L I A S V D L Y T H S E Y Y N H A I D W Q T G P G C N T A G F F T V F A S E L S V Y T L T V I T L E R W Y A I T F A M R L D R K I R L R H A C A I M V G G W V C C F L L A L L P L V G I S S Y A K V S I C L P M D T E T P L A L A Y I V F V L T L N I V A F V I V C C C Y V K I Y I T V R N P D K D T K I A K R M A V L I F T D F I C M A P I S F Y A L S A I L N K P L I T V S N S K I L L V L F Y P L N S C A N P F L Y A I F T K A F Q R D V F I L L S K F G Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

Chain	L
Protein	TSH
UniProt	P01215
Sequence	>7XW5_nogp_Chain_L F C I P T E Y T M H I E R R E C A Y C L T I N T T I C A G Y C M T R D I N G K L F L P K Y A L S Q D V C T Y R D F I Y R T V E I P G C P L H V A P Y F S Y P V A L S C K C G K C N T D Y S D C I H E A I K T N Y C Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	7T9I	A	Protein	Glycoprotein Hormone	TSH	Homo sapiens	TSH	-	Gs/β1/γ2	2.9	2022-08-03	doi.org/10.1038/s41586-022-05159-1
	7T9I (No Gprot)	A	Protein	Glycoprotein Hormone	TSH	Homo sapiens	TSH	-		2.9	2022-08-03	doi.org/10.1038/s41586-022-05159-1
	7T9N	A	Protein	Glycoprotein Hormone	TSH	Homo sapiens	M22 Fab	DPPC	Gs/β1/γ2	2.9	2022-08-03	doi.org/10.1038/s41586-022-05159-1
	7T9N (No Gprot)	A	Protein	Glycoprotein Hormone	TSH	Homo sapiens	M22 Fab	DPPC		2.9	2022-08-03	doi.org/10.1038/s41586-022-05159-1
	7UTZ	A	Protein	Glycoprotein Hormone	TSH	Homo sapiens	TSH	DPPC	Gs/β1/γ2	2.4	2022-08-03	doi.org/10.1038/s41586-022-05159-1
	7UTZ (No Gprot)	A	Protein	Glycoprotein Hormone	TSH	Homo sapiens	TSH	DPPC		2.4	2022-08-03	doi.org/10.1038/s41586-022-05159-1
	7T9M	A	Protein	Glycoprotein Hormone	TSH	Homo sapiens	-	CS-17 Antibody	-	3.1	2022-08-10	doi.org/10.1038/s41586-022-05159-1
	7XW6	A	Protein	Glycoprotein Hormone	TSH	Homo sapiens	M22 Fab	ML109	Gs/β1/γ2	2.78	2022-08-17	doi.org/10.1038/s41586-022-05173-3
	7XW6 (No Gprot)	A	Protein	Glycoprotein Hormone	TSH	Homo sapiens	M22 Fab	ML109		2.78	2022-08-17	doi.org/10.1038/s41586-022-05173-3
	7XW7	A	Protein	Glycoprotein Hormone	TSH	Homo sapiens	K1-70	-	-	5.5	2022-08-17	doi.org/10.1038/s41586-022-05173-3
	7XW5	A	Protein	Glycoprotein Hormone	TSH	Homo sapiens	TSH	ML109	Gs/β1/γ2	2.96	2022-08-24	doi.org/10.1038/s41586-022-05173-3
	7XW5 (No Gprot)	A	Protein	Glycoprotein Hormone	TSH	Homo sapiens	TSH	ML109		2.96	2022-08-24	doi.org/10.1038/s41586-022-05173-3

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