psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:L1	N:N:S63	9.01	No	No	0	0	0
2	L:L:L101	L:L:T2	2.95	Yes	No	0	0	0
3	L:L:C23	L:L:L4	3.17	No	Yes	6	0	0
4	L:L:L4	L:L:N29	4.12	Yes	Yes	6	0	0
5	L:L:I30	L:L:L4	4.28	Yes	Yes	6	0	0
6	L:L:C90	L:L:L4	3.17	Yes	Yes	6	0	0
7	L:L:L4	L:L:S92	6.01	Yes	No	6	0	0
8	L:L:L101	L:L:L4	4.15	Yes	Yes	6	0	0
9	L:L:G103	L:L:L4	5.13	No	Yes	0	0	0
10	L:L:S24	L:L:T5	6.4	No	No	0	0	0
11	L:L:P7	L:L:Q6	3.16	Yes	Yes	6	0	0
12	L:L:C90	L:L:Q6	6.1	Yes	Yes	6	0	0
13	L:L:G103	L:L:Q6	4.93	No	Yes	0	0	0
14	L:L:G105	L:L:Q6	6.58	No	Yes	0	0	0
15	L:L:Q6	L:L:T106	7.09	Yes	Yes	6	0	0
16	L:L:I21	L:L:P7	3.39	Yes	Yes	6	0	0
17	L:L:P7	L:L:T106	5.25	Yes	Yes	6	0	0
18	L:L:I21	L:L:V11	6.14	Yes	No	6	0	0
19	L:L:T106	L:L:V11	3.17	Yes	No	6	0	0
20	L:L:L108	L:L:V11	4.47	No	No	0	0	0
21	L:L:L111	L:L:S12	6.01	No	No	0	0	0
22	L:L:A14	L:L:Q17	6.06	No	No	0	0	0
23	L:L:Q81	L:L:R16	8.18	No	No	0	0	0
24	L:L:R18	L:L:R78	4.26	No	No	0	0	0
25	L:L:I77	L:L:V19	4.61	Yes	No	1	0	0
26	L:L:L80	L:L:V19	2.98	Yes	No	1	0	0
27	L:L:S74	L:L:T20	3.2	No	No	0	0	0
28	L:L:A76	L:L:T20	3.36	No	No	0	0	0
29	L:L:I21	L:L:L75	4.28	Yes	Yes	0	0	0
30	L:L:I21	L:L:T106	6.08	Yes	Yes	6	0	0
31	L:L:C23	L:L:W37	2.61	No	Yes	6	0	0
32	L:L:C23	L:L:C90	7.28	No	Yes	6	0	0
33	L:L:S24	L:L:S72	3.26	No	No	0	0	0
34	L:L:N26	L:L:N29	5.45	No	Yes	0	0	0
35	L:L:N29	L:L:S28	2.98	Yes	No	6	0	0
36	L:L:D94	L:L:S28	8.83	Yes	No	6	0	0
37	L:L:S28	L:L:S96	6.52	No	No	6	0	0
38	L:L:I30	L:L:N29	5.66	Yes	Yes	6	0	0
39	L:L:N29	L:L:S92	4.47	Yes	No	6	0	0
40	L:L:D94	L:L:N29	10.77	Yes	Yes	6	0	0
41	L:L:L101	L:L:N29	2.75	Yes	Yes	6	0	0
42	L:L:I30	L:L:V35	6.14	Yes	No	0	0	0
43	L:L:I30	L:L:S92	3.1	Yes	No	6	0	0
44	L:L:N32	L:L:N33	10.9	Yes	Yes	1	0	0
45	L:L:D95	L:L:N32	6.73	Yes	Yes	1	0	0
46	L:L:N32	R:R:I85	2.83	Yes	Yes	1	0	6
47	L:L:N32	R:R:N110	12.26	Yes	No	1	0	6
48	L:L:N33	L:L:W93	5.65	Yes	Yes	1	0	0
49	L:L:D95	L:L:N33	8.08	Yes	Yes	1	0	0
50	L:L:N33	R:R:R109	6.03	Yes	Yes	1	0	5
51	L:L:N33	N:N:S104	4.47	Yes	No	1	0	0
52	L:L:A34	L:L:D53	4.63	No	No	0	0	0
53	L:L:V35	L:L:W37	3.68	No	Yes	0	0	0
54	L:L:A73	L:L:V35	5.09	No	No	0	0	0
55	L:L:N36	L:L:T91	4.39	No	Yes	1	0	0
56	L:L:N36	N:N:T106	5.85	No	No	1	0	0
57	L:L:N36	N:N:W107	3.39	No	Yes	1	0	0
58	L:L:I50	L:L:W37	3.52	No	Yes	0	0	0
59	L:L:L75	L:L:W37	13.67	Yes	Yes	0	0	0
60	L:L:C90	L:L:W37	10.45	Yes	Yes	6	0	0
61	L:L:L48	L:L:Y38	9.38	Yes	Yes	1	0	0
62	L:L:T91	L:L:Y38	4.99	Yes	Yes	1	0	0
63	L:L:Y38	N:N:S108	3.82	Yes	Yes	1	0	0
64	L:L:Y38	N:N:W111	12.54	Yes	Yes	1	0	0
65	L:L:L41	L:L:Q39	5.32	Yes	Yes	1	0	0
66	L:L:K47	L:L:Q39	5.42	No	Yes	0	0	0
67	L:L:L49	L:L:Q39	5.32	Yes	Yes	1	0	0
68	L:L:A86	L:L:Q39	4.55	No	Yes	1	0	0
69	L:L:Q39	L:L:Y88	14.65	Yes	Yes	1	0	0
70	L:L:P46	L:L:Q40	14.21	No	No	1	0	0
71	L:L:Q40	N:N:Q39	3.84	No	No	1	0	0
72	L:L:Q40	N:N:Y95	3.38	No	Yes	1	0	0
73	L:L:L41	L:L:P42	3.28	Yes	No	0	0	0
74	L:L:K44	L:L:L41	2.82	No	Yes	0	0	0
75	L:L:A86	L:L:L41	3.15	No	Yes	1	0	0
76	L:L:A45	N:N:Y95	5.34	No	Yes	0	0	0
77	L:L:P46	N:N:Y95	9.74	No	Yes	1	0	0
78	L:L:P46	N:N:W111	5.4	No	Yes	1	0	0
79	L:L:L48	L:L:Y51	5.86	Yes	Yes	1	0	0
80	L:L:L48	L:L:P57	6.57	Yes	Yes	1	0	0
81	L:L:L48	N:N:W107	3.42	Yes	Yes	1	0	0
82	L:L:L49	L:L:V60	2.98	Yes	Yes	1	0	0
83	L:L:F64	L:L:L49	14.61	Yes	Yes	1	0	0
84	L:L:L49	L:L:L75	4.15	Yes	Yes	0	0	0
85	L:L:I50	L:L:L56	5.71	No	Yes	0	0	0
86	L:L:Y51	L:L:Y52	2.98	Yes	No	1	0	0
87	L:L:Q55	L:L:Y51	6.76	Yes	Yes	0	0	0
88	L:L:P57	L:L:Y51	6.95	Yes	Yes	1	0	0
89	L:L:Y51	R:R:Y185	8.94	Yes	Yes	1	0	7
90	L:L:Y51	N:N:W107	21.22	Yes	Yes	1	0	0
91	L:L:Y52	N:N:W107	10.61	No	Yes	1	0	0
92	L:L:D53	L:L:R68	22.63	No	No	0	0	0
93	L:L:D53	R:R:K209	4.15	No	No	0	0	7
94	L:L:D54	L:L:G66	3.35	No	No	0	0	0
95	L:L:D54	R:R:Q235	2.61	No	No	0	0	4
96	L:L:Q55	R:R:N208	7.92	Yes	Yes	0	0	5
97	L:L:Q55	R:R:K209	10.85	Yes	No	0	0	7
98	L:L:Q55	R:R:Q235	5.12	Yes	No	0	0	4
99	L:L:L56	L:L:P57	4.93	Yes	Yes	1	0	0
100	L:L:L56	L:L:V60	5.96	Yes	Yes	1	0	0
101	L:L:L56	R:R:R255	9.72	Yes	Yes	1	0	4
102	L:L:P57	L:L:V60	7.07	Yes	Yes	1	0	0
103	L:L:S58	R:R:R274	5.27	No	Yes	1	0	3
104	L:L:S58	R:R:D276	5.89	No	Yes	1	0	4
105	L:L:G59	R:R:R274	3	No	Yes	0	0	3
106	L:L:F64	L:L:V60	3.93	Yes	Yes	1	0	0
107	L:L:R63	L:L:S61	14.5	Yes	No	1	0	0
108	L:L:F64	L:L:S61	2.64	Yes	No	1	0	0
109	L:L:F64	L:L:R63	3.21	Yes	Yes	1	0	0
110	L:L:Q81	L:L:R63	5.84	No	Yes	0	0	0
111	L:L:D84	L:L:R63	11.91	Yes	Yes	1	0	0
112	L:L:F64	L:L:I77	7.54	Yes	Yes	1	0	0
113	L:L:D84	L:L:F64	3.58	Yes	Yes	1	0	0
114	L:L:F64	L:L:Y88	4.13	Yes	Yes	1	0	0
115	L:L:S67	L:L:S74	4.89	No	No	0	0	0
116	L:L:A73	L:L:R68	2.77	No	No	0	0	0
117	L:L:L75	L:L:Y88	4.69	Yes	Yes	0	0	0
118	L:L:I77	L:L:L80	2.85	Yes	Yes	1	0	0
119	L:L:D84	L:L:I77	2.8	Yes	Yes	1	0	0
120	L:L:D84	L:L:L80	4.07	Yes	Yes	1	0	0
121	L:L:L108	L:L:L80	2.77	No	Yes	0	0	0
122	L:L:Q113	L:L:S82	5.78	No	No	0	0	0
123	L:L:E85	L:L:T109	4.23	No	No	0	0	0
124	L:L:E85	L:L:V110	8.56	No	No	0	0	0
125	L:L:A86	L:L:Y88	5.34	No	Yes	1	0	0
126	L:L:D87	L:L:Y89	5.75	No	Yes	0	0	0
127	L:L:D87	L:L:R107	17.87	No	No	0	0	0
128	L:L:L108	L:L:Y88	4.69	No	Yes	0	0	0
129	L:L:G105	L:L:Y89	4.35	No	Yes	0	0	0
130	L:L:Y89	N:N:Q39	4.51	Yes	No	1	0	0
131	L:L:Y89	N:N:G44	4.35	Yes	No	0	0	0
132	L:L:Y89	N:N:L45	17.58	Yes	Yes	1	0	0
133	L:L:F102	L:L:T91	5.19	Yes	Yes	1	0	0
134	L:L:T91	N:N:T106	7.85	Yes	No	1	0	0
135	L:L:D95	L:L:W93	3.35	Yes	Yes	1	0	0
136	L:L:D98	L:L:W93	3.35	No	Yes	1	0	0
137	L:L:W93	N:N:W47	2.81	Yes	Yes	1	0	0
138	L:L:W93	N:N:R50	12	Yes	Yes	1	0	0
139	L:L:W93	N:N:Y103	6.75	Yes	Yes	1	0	0
140	L:L:W93	N:N:S104	3.71	Yes	No	1	0	0
141	L:L:D94	L:L:S96	2.94	Yes	No	6	0	0
142	L:L:D94	L:L:L97	9.5	Yes	No	0	0	0
143	L:L:D94	L:L:L101	4.07	Yes	Yes	6	0	0
144	L:L:D95	R:R:I85	4.2	Yes	Yes	1	0	6
145	L:L:D95	R:R:R109	10.72	Yes	Yes	1	0	5
146	L:L:L97	L:L:S99	3	No	No	0	0	0
147	L:L:D98	R:R:K58	5.53	No	Yes	1	0	5
148	L:L:D98	N:N:Y103	9.2	No	Yes	1	0	0
149	L:L:S99	N:N:W47	4.94	No	Yes	0	0	0
150	L:L:S99	N:N:P62	3.56	No	No	0	0	0
151	L:L:F102	L:L:Q100	8.2	Yes	Yes	1	0	0
152	L:L:Q100	N:N:N35	6.6	Yes	Yes	1	0	0
153	L:L:Q100	N:N:W47	20.81	Yes	Yes	1	0	0
154	L:L:Q100	N:N:T106	12.76	Yes	No	1	0	0
155	L:L:F102	N:N:V37	7.87	Yes	No	1	0	0
156	L:L:F102	N:N:L45	12.18	Yes	Yes	1	0	0
157	L:L:Q113	L:L:V110	5.73	No	No	0	0	0
158	R:R:D43	R:R:P28	6.44	No	No	0	4	2
159	R:R:I44	R:R:P28	3.39	Yes	No	0	5	2
160	R:R:C29	R:R:C41	7.28	No	No	0	9	9
161	R:R:E30	R:R:H32	4.92	No	No	0	3	5
162	R:R:C31	R:R:F37	5.59	No	Yes	0	8	1
163	R:R:F37	R:R:Q33	8.2	Yes	No	0	1	5
164	R:R:E34	R:R:R38	5.82	No	Yes	0	4	4
165	N:N:T58	R:R:E34	8.47	Yes	No	0	0	4
166	N:N:S56	R:R:E35	11.5	No	No	0	0	1
167	R:R:D36	R:R:R38	3.57	No	Yes	0	3	4
168	R:R:D36	R:R:Q55	15.66	No	No	0	3	4
169	R:R:F37	R:R:V39	2.62	Yes	Yes	2	1	6
170	R:R:F37	R:R:P51	7.22	Yes	Yes	2	1	5
171	R:R:F37	R:R:S53	11.89	Yes	No	0	1	5
172	R:R:F37	R:R:T54	3.89	Yes	Yes	2	1	7
173	R:R:R38	R:R:T56	12.94	Yes	No	0	4	5
174	N:N:Y57	R:R:R38	17.49	Yes	Yes	0	0	4
175	R:R:L50	R:R:V39	5.96	Yes	Yes	2	5	6
176	R:R:T54	R:R:V39	6.35	Yes	Yes	2	7	6
177	R:R:L57	R:R:V39	2.98	No	Yes	2	7	6
178	R:R:K58	R:R:T40	12.01	Yes	No	0	5	8
179	R:R:C41	R:R:I44	6.55	No	Yes	0	9	5
180	R:R:D43	R:R:K42	6.91	No	No	0	4	2
181	R:R:I44	R:R:P48	3.39	Yes	No	0	5	9
182	R:R:I44	R:R:T62	4.56	Yes	Yes	2	5	7
183	R:R:I44	R:R:L64	2.85	Yes	Yes	2	5	6
184	R:R:I47	R:R:P48	3.39	Yes	No	0	4	9
185	R:R:I47	R:R:L64	4.28	Yes	Yes	2	4	6
186	R:R:I47	R:R:I67	2.94	Yes	Yes	2	4	5
187	R:R:F72	R:R:I47	5.02	Yes	Yes	2	9	4
188	R:R:L50	R:R:P48	3.28	Yes	No	0	5	9
189	R:R:L50	R:R:P51	4.93	Yes	Yes	2	5	5
190	R:R:L50	R:R:L57	2.77	Yes	No	2	5	7
191	R:R:L50	R:R:L75	4.15	Yes	No	0	5	6
192	R:R:P51	R:R:T54	3.5	Yes	Yes	2	5	7
193	R:R:P52	R:R:P76	3.9	No	No	0	3	5
194	H:H:?4	R:R:S53	4.04	No	No	0	0	5
195	R:R:L75	R:R:T54	5.9	No	Yes	0	6	7
196	R:R:N77	R:R:Q55	13.2	No	No	14	8	4
197	H:H:?4	R:R:Q55	5.97	No	No	14	0	4
198	R:R:R80	R:R:T56	3.88	Yes	No	0	4	5
199	R:R:L57	R:R:L59	5.54	No	No	2	7	6
200	R:R:I60	R:R:K58	5.82	No	Yes	0	4	5
201	N:N:Y103	R:R:K58	7.17	Yes	Yes	1	0	5
202	R:R:L59	R:R:T62	4.42	No	Yes	2	6	7
203	R:R:L59	R:R:L64	2.77	No	Yes	2	6	6
204	R:R:E61	R:R:I60	2.73	No	No	0	5	4
205	R:R:I60	R:R:S84	6.19	No	No	0	4	7
206	R:R:E61	R:R:I85	5.47	No	Yes	0	5	6
207	R:R:L64	R:R:T62	4.42	Yes	Yes	2	6	7
208	R:R:D86	R:R:T62	7.23	Yes	Yes	2	8	7
209	R:R:H63	R:R:V87	2.77	No	No	0	4	4
210	R:R:H63	R:R:T88	10.95	No	No	0	4	4
211	R:R:D86	R:R:L64	5.43	Yes	Yes	2	8	6
212	R:R:R65	R:R:T88	2.59	No	No	0	4	4
213	R:R:E93	R:R:T66	5.64	No	No	0	6	5
214	R:R:I67	R:R:P68	3.39	Yes	No	0	5	5
215	R:R:F72	R:R:I67	5.02	Yes	Yes	2	9	5
216	R:R:I67	R:R:L92	4.28	Yes	Yes	2	5	8
217	R:R:I67	R:R:S96	6.19	Yes	Yes	2	5	7
218	R:R:A71	R:R:P68	3.74	No	No	0	8	5
219	R:R:E93	R:R:P68	3.14	No	No	0	6	5
220	R:R:H70	R:R:S69	2.79	Yes	No	0	4	4
221	R:R:E93	R:R:S69	4.31	No	No	0	6	4
222	R:R:S69	R:R:S94	3.26	No	No	0	4	4
223	R:R:H70	R:R:S73	2.79	Yes	No	0	4	4
224	R:R:H70	R:R:H95	15.53	Yes	Yes	9	4	5
225	R:R:H70	R:R:Y98	4.36	Yes	Yes	9	4	2
226	R:R:F72	R:R:I81	5.02	Yes	Yes	2	9	8
227	R:R:F72	R:R:F97	7.5	Yes	No	2	9	9
228	R:R:I78	R:R:L75	5.71	No	No	0	7	6
229	H:H:?4	R:R:N77	28.34	No	No	14	0	8
230	R:R:I78	R:R:I81	4.42	No	Yes	0	7	8
231	R:R:R80	R:R:S79	5.27	Yes	No	1	4	7
232	R:R:S79	R:R:T104	6.4	No	No	1	7	5
233	N:N:D55	R:R:S79	7.36	Yes	No	1	0	7
234	R:R:R80	R:R:Y82	12.35	Yes	No	1	4	4
235	R:R:H105	R:R:R80	16.93	Yes	Yes	1	7	4
236	N:N:D52	R:R:R80	10.72	Yes	Yes	1	0	4
237	N:N:T54	R:R:R80	2.59	Yes	Yes	1	0	4
238	N:N:D55	R:R:R80	13.1	Yes	Yes	1	0	4
239	N:N:Y57	R:R:R80	8.23	Yes	Yes	1	0	4
240	R:R:F97	R:R:I81	5.02	No	Yes	2	9	8
241	R:R:I106	R:R:I81	2.94	No	Yes	2	7	8
242	R:R:E107	R:R:Y82	8.98	Yes	No	1	6	4
243	N:N:Y103	R:R:Y82	11.91	Yes	No	1	0	4
244	R:R:I108	R:R:V83	4.61	No	No	0	8	6
245	R:R:I85	R:R:N110	11.33	Yes	No	1	6	6
246	R:R:D86	R:R:T88	2.89	Yes	No	0	8	4
247	R:R:D86	R:R:L89	4.07	Yes	Yes	2	8	8
248	R:R:R112	R:R:V87	5.23	No	No	0	6	4
249	R:R:L89	R:R:L92	2.77	Yes	Yes	2	8	8
250	R:R:L89	R:R:T111	2.95	Yes	Yes	2	8	5
251	R:R:L114	R:R:L89	8.3	Yes	Yes	2	8	8
252	R:R:Q91	R:R:Y116	5.64	No	No	0	3	3
253	R:R:L92	R:R:S96	3	Yes	Yes	2	8	7
254	R:R:I117	R:R:L92	8.56	No	Yes	0	8	8
255	R:R:H95	R:R:S94	5.58	Yes	No	0	5	4
256	R:R:D118	R:R:S94	5.89	Yes	No	0	5	4
257	R:R:H95	R:R:Y98	14.16	Yes	Yes	9	5	2
258	R:R:H95	R:R:K123	3.93	Yes	Yes	9	5	4
259	R:R:F97	R:R:S96	2.64	No	Yes	2	9	7
260	R:R:A121	R:R:S96	3.42	No	Yes	0	9	7
261	R:R:N99	R:R:Y98	10.47	No	Yes	9	5	2
262	R:R:K123	R:R:Y98	9.55	Yes	Yes	9	4	2
263	R:R:E124	R:R:Y98	13.47	No	Yes	9	4	2
264	H:H:?3	R:R:Y98	10.52	No	Yes	9	0	2
265	H:H:?3	R:R:N99	25.87	No	No	9	0	5
266	R:R:L100	R:R:V103	4.47	No	No	0	8	5
267	R:R:K102	R:R:S101	3.06	No	No	0	4	4
268	R:R:L125	R:R:V103	5.96	No	No	2	8	5
269	R:R:L128	R:R:V103	2.98	Yes	No	2	9	5
270	R:R:H105	R:R:T104	5.48	Yes	No	1	7	5
271	N:N:T54	R:R:T104	3.14	Yes	No	1	0	5
272	R:R:F130	R:R:H105	7.92	Yes	Yes	1	6	7
273	N:N:D52	R:R:H105	6.3	Yes	Yes	1	0	7
274	N:N:T54	R:R:H105	2.74	Yes	Yes	1	0	7
275	R:R:I106	R:R:L128	5.71	No	Yes	2	7	9
276	R:R:I106	R:R:L131	4.28	No	Yes	2	7	8
277	R:R:E107	R:R:R109	11.63	Yes	Yes	1	6	5
278	R:R:E107	R:R:F134	8.16	Yes	Yes	1	6	5
279	N:N:Y103	R:R:E107	3.37	Yes	Yes	1	0	6
280	R:R:I108	R:R:T111	4.56	No	Yes	2	8	5
281	R:R:I108	R:R:L114	2.85	No	Yes	2	8	8
282	R:R:F134	R:R:R109	8.55	Yes	Yes	1	5	5
283	N:N:S104	R:R:R109	10.54	No	Yes	1	0	5
284	R:R:L114	R:R:T111	4.42	Yes	Yes	2	8	5
285	R:R:T111	R:R:T136	3.14	Yes	Yes	2	5	9
286	R:R:I117	R:R:L114	2.85	No	Yes	0	8	8
287	R:R:D118	R:R:Y116	8.05	Yes	No	15	5	3
288	R:R:P119	R:R:Y116	5.56	No	No	15	4	3
289	R:R:I117	R:R:L138	4.28	No	No	0	8	8
290	R:R:D118	R:R:P119	6.44	Yes	No	15	5	4
291	R:R:D118	R:R:D120	3.99	Yes	No	0	5	5
292	R:R:D143	R:R:P119	3.22	No	No	0	5	4
293	R:R:D120	R:R:K146	5.53	No	No	0	5	4
294	R:R:L122	R:R:L131	2.77	No	Yes	0	7	8
295	R:R:E124	R:R:K123	16.2	No	Yes	9	4	4
296	R:R:K123	R:R:K146	5.75	Yes	No	0	4	4
297	R:R:L125	R:R:L128	2.77	No	Yes	2	8	9
298	R:R:P126	R:R:T150	3.5	No	No	0	5	3
299	R:R:L128	R:R:L131	4.15	Yes	Yes	2	9	8
300	R:R:L128	R:R:V147	2.98	Yes	No	0	9	7
301	R:R:F154	R:R:L128	6.09	Yes	Yes	2	6	9
302	R:R:D151	R:R:K129	6.91	No	No	0	4	5
303	N:N:T30	R:R:K129	3	No	No	0	0	5
304	N:N:T54	R:R:K129	6.01	Yes	No	0	0	5
305	R:R:F130	R:R:G132	3.01	Yes	No	1	6	5
306	R:R:F130	R:R:I155	3.77	Yes	Yes	1	6	5
307	R:R:E157	R:R:F130	4.66	Yes	Yes	1	8	6
308	N:N:P101	R:R:F130	5.78	Yes	Yes	1	0	6
309	N:N:G102	R:R:F130	4.52	No	Yes	0	0	6
310	R:R:I133	R:R:L131	2.85	Yes	Yes	2	8	8
311	R:R:L131	R:R:L144	5.54	Yes	Yes	0	8	7
312	R:R:F154	R:R:L131	3.65	Yes	Yes	2	6	8
313	R:R:F134	R:R:G132	3.01	Yes	No	1	5	5
314	R:R:E157	R:R:G132	3.27	Yes	No	1	8	5
315	R:R:I133	R:R:T136	4.56	Yes	Yes	2	8	9
316	R:R:I133	R:R:P142	3.39	Yes	Yes	0	8	9
317	R:R:I133	R:R:I158	2.94	Yes	Yes	2	8	7
318	R:R:I133	R:R:N161	5.66	Yes	Yes	2	8	8
319	R:R:E157	R:R:F134	8.16	Yes	Yes	1	8	5
320	R:R:F134	R:R:T159	5.19	Yes	Yes	1	5	5
321	R:R:D160	R:R:N135	12.12	No	No	0	8	8
322	R:R:G137	R:R:T136	3.64	No	Yes	0	8	9
323	R:R:L138	R:R:T136	11.79	No	Yes	0	8	9
324	R:R:N161	R:R:T136	8.77	Yes	Yes	2	8	9
325	R:R:L138	R:R:M164	4.24	No	Yes	0	8	7
326	R:R:F141	R:R:P142	5.78	Yes	Yes	0	7	9
327	R:R:F141	R:R:I158	3.77	Yes	Yes	2	7	7
328	R:R:F141	R:R:I167	3.77	Yes	Yes	2	7	7
329	R:R:F141	R:R:P168	8.67	Yes	Yes	2	7	6
330	R:R:A171	R:R:F141	2.77	No	Yes	2	7	7
331	R:R:F141	R:R:F172	4.29	Yes	Yes	2	7	8
332	R:R:F141	R:R:F189	4.29	Yes	Yes	2	7	8
333	R:R:L144	R:R:P142	3.28	Yes	Yes	0	7	9
334	R:R:M164	R:R:P142	5.03	Yes	Yes	0	7	9
335	R:R:D143	R:R:T145	10.12	No	No	0	5	4
336	R:R:L144	R:R:L156	2.77	Yes	No	0	7	7
337	R:R:L144	R:R:L175	6.92	Yes	Yes	0	7	7
338	R:R:S149	R:R:V147	3.23	No	No	0	8	7
339	R:R:L175	R:R:V147	4.47	Yes	No	0	7	7
340	H:H:?2	R:R:Y148	3.16	Yes	No	0	0	4
341	R:R:F154	R:R:S149	5.28	Yes	No	0	6	8
342	H:H:?2	R:R:T150	6.61	Yes	No	0	0	3
343	N:N:R28	R:R:I152	3.76	No	No	0	0	3
344	R:R:F153	R:R:I155	5.02	Yes	Yes	1	5	5
345	R:R:F153	R:R:T179	6.49	Yes	No	0	5	5
346	R:R:F153	R:R:T181	3.89	Yes	No	1	5	7
347	N:N:S31	R:R:F153	5.28	No	Yes	0	0	5
348	N:N:Y32	R:R:F153	4.13	Yes	Yes	1	0	5
349	R:R:F154	R:R:L175	9.74	Yes	Yes	2	6	7
350	R:R:C176	R:R:F154	4.19	No	Yes	0	6	6
351	R:R:F154	R:R:L180	4.87	Yes	Yes	2	6	7
352	R:R:I155	R:R:T181	4.56	Yes	No	1	5	7
353	N:N:P101	R:R:I155	5.08	Yes	Yes	1	0	5
354	R:R:I158	R:R:L156	8.56	Yes	No	0	7	7
355	R:R:L156	R:R:L182	5.54	No	Yes	0	7	6
356	R:R:E157	R:R:T159	8.47	Yes	Yes	1	8	5
357	R:R:E157	R:R:K183	8.1	Yes	Yes	1	8	6
358	R:R:I158	R:R:N161	4.25	Yes	Yes	2	7	8
359	R:R:I158	R:R:M164	2.92	Yes	Yes	2	7	7
360	R:R:I158	R:R:L184	2.85	Yes	No	0	7	8
361	R:R:I158	R:R:N187	5.66	Yes	Yes	2	7	9
362	R:R:D160	R:R:T159	5.78	No	Yes	0	8	5
363	R:R:T159	R:R:Y185	6.24	Yes	Yes	1	5	7
364	R:R:D160	R:R:N186	6.73	No	No	0	8	7
365	R:R:M164	R:R:N161	7.01	Yes	Yes	2	7	8
366	R:R:N161	R:R:N187	6.81	Yes	Yes	2	8	9
367	R:R:P162	R:R:Y163	6.95	No	No	0	7	4
368	R:R:F189	R:R:M164	7.46	Yes	Yes	2	8	7
369	R:R:S166	R:R:T165	3.2	No	No	0	5	4
370	R:R:Q193	R:R:S166	5.78	No	No	0	5	5
371	R:R:I167	R:R:P168	3.39	Yes	Yes	2	7	6
372	R:R:F189	R:R:I167	7.54	Yes	Yes	2	8	7
373	R:R:I167	R:R:V192	4.61	Yes	Yes	0	7	7
374	R:R:A171	R:R:P168	3.74	No	Yes	2	7	6
375	R:R:N170	R:R:V169	5.91	Yes	No	0	8	5
376	R:R:Q193	R:R:V169	2.87	No	No	0	5	5
377	R:R:N170	R:R:Q173	10.56	Yes	Yes	10	8	2
378	R:R:N170	R:R:N198	5.45	Yes	Yes	10	8	7
379	H:H:?1	R:R:N170	12.32	Yes	Yes	10	0	8
380	R:R:A171	R:R:F172	4.16	No	Yes	2	7	8
381	R:R:F172	R:R:L180	3.65	Yes	Yes	2	8	7
382	R:R:F172	R:R:L182	8.53	Yes	Yes	2	8	6
383	R:R:F172	R:R:F197	5.36	Yes	Yes	0	8	9
384	R:R:N198	R:R:Q173	2.64	Yes	Yes	10	7	2
385	R:R:G199	R:R:Q173	3.29	No	Yes	10	7	2
386	H:H:?1	R:R:Q173	8.36	Yes	Yes	10	0	2
387	R:R:L175	R:R:L180	4.15	Yes	Yes	2	7	7
388	R:R:E178	R:R:N177	3.94	No	No	16	5	5
389	H:H:?2	R:R:N177	29.57	Yes	No	16	0	5
390	R:R:E178	R:R:K201	2.7	No	No	0	5	4
391	H:H:?2	R:R:E178	8.32	Yes	No	16	0	5
392	R:R:L180	R:R:L182	4.15	Yes	Yes	2	7	6
393	R:R:L180	R:R:L202	4.15	Yes	Yes	2	7	8
394	R:R:A204	R:R:T181	3.36	No	No	1	5	7
395	R:R:L182	R:R:L184	4.15	Yes	No	0	6	8
396	R:R:L182	R:R:L202	2.77	Yes	Yes	2	6	8
397	R:R:L182	R:R:V205	2.98	Yes	Yes	2	6	7
398	R:R:K183	R:R:Y185	3.58	Yes	Yes	1	6	7
399	N:N:E100	R:R:K183	6.75	Yes	Yes	1	0	6
400	N:N:W107	R:R:K183	9.28	Yes	Yes	1	0	6
401	R:R:L184	R:R:L207	2.77	No	Yes	0	8	7
402	R:R:Y185	R:R:Y206	5.96	Yes	Yes	1	7	6
403	R:R:N208	R:R:Y185	17.44	Yes	Yes	1	5	7
404	N:N:W107	R:R:Y185	3.86	Yes	Yes	1	0	7
405	R:R:K209	R:R:N186	13.99	No	No	0	7	7
406	R:R:F189	R:R:N187	14.5	Yes	Yes	2	8	9
407	R:R:N187	R:R:N210	4.09	Yes	No	2	9	9
408	R:R:F189	R:R:N210	4.83	Yes	No	2	8	9
409	R:R:S191	R:R:V215	4.85	No	No	0	4	2
410	R:R:F197	R:R:V192	2.62	Yes	Yes	0	9	7
411	R:R:L213	R:R:V192	2.98	Yes	Yes	0	9	7
412	R:R:I216	R:R:V192	3.07	No	Yes	0	6	7
413	R:R:D217	R:R:G194	5.03	No	No	0	5	3
414	R:R:D219	R:R:Y195	12.64	No	No	0	3	4
415	R:R:G222	R:R:Y195	2.9	No	No	0	3	4
416	H:H:?1	R:R:Y195	7.36	Yes	No	0	0	4
417	R:R:A196	R:R:F197	4.16	No	Yes	0	9	9
418	R:R:F197	R:R:L202	3.65	Yes	Yes	0	9	8
419	R:R:F197	R:R:F221	17.15	Yes	Yes	0	9	9
420	R:R:G199	R:R:N198	3.39	No	Yes	10	7	7
421	R:R:G223	R:R:N198	3.39	No	Yes	0	7	7
422	H:H:?1	R:R:N198	24.64	Yes	Yes	10	0	7
423	R:R:G199	R:R:Y225	8.69	No	No	0	7	4
424	R:R:L202	R:R:T200	7.37	Yes	No	0	8	8
425	R:R:T200	R:R:V224	3.17	No	No	0	8	7
426	R:R:L202	R:R:V205	5.96	Yes	Yes	2	8	7
427	R:R:D203	R:R:S229	5.89	No	No	0	6	5
428	R:R:A204	R:R:Y206	4	No	Yes	1	5	6
429	R:R:A204	R:R:L230	3.15	No	Yes	1	5	4
430	R:R:L207	R:R:V205	2.98	Yes	Yes	0	7	7
431	R:R:P228	R:R:V205	3.53	Yes	Yes	2	8	7
432	R:R:L231	R:R:V205	2.98	Yes	Yes	2	7	7
433	R:R:N208	R:R:Y206	3.49	Yes	Yes	1	5	6
434	R:R:L230	R:R:Y206	11.72	Yes	Yes	1	4	6
435	R:R:D232	R:R:Y206	5.75	Yes	Yes	1	9	6
436	R:R:L207	R:R:L213	2.77	Yes	Yes	0	7	9
437	R:R:L207	R:R:V233	2.98	Yes	Yes	0	7	7
438	R:R:D232	R:R:N208	16.16	Yes	Yes	1	9	5
439	R:R:L213	R:R:N210	2.75	Yes	No	0	9	9
440	R:R:L213	R:R:V238	2.98	Yes	Yes	0	9	7
441	R:R:T214	R:R:V215	3.17	No	No	0	4	2
442	R:R:I216	R:R:V238	3.07	No	Yes	0	6	7
443	R:R:I216	R:R:P242	6.77	No	No	0	6	9
444	R:R:D217	R:R:K218	2.77	No	No	0	5	4
445	R:R:D219	R:R:K218	5.53	No	No	0	3	4
446	R:R:F221	R:R:V224	2.62	Yes	No	0	9	7
447	R:R:F221	R:R:P228	5.78	Yes	Yes	2	9	8
448	R:R:F221	R:R:P242	4.33	Yes	No	0	9	9
449	R:R:F221	R:R:L246	9.74	Yes	No	2	9	7
450	R:R:G227	R:R:P228	4.06	No	Yes	0	7	8
451	R:R:G227	R:R:H248	4.77	No	No	0	7	4
452	R:R:L246	R:R:P228	3.28	No	Yes	2	7	8
453	R:R:E251	R:R:L230	5.3	No	Yes	0	5	4
454	R:R:I253	R:R:L230	2.85	No	Yes	0	4	4
455	R:R:L231	R:R:V233	4.47	Yes	Yes	0	7	7
456	R:R:L231	R:R:L246	2.77	Yes	No	2	7	7
457	R:R:L231	R:R:L249	2.77	Yes	No	2	7	8
458	R:R:L231	R:R:L252	2.77	Yes	Yes	2	7	9
459	R:R:D232	R:R:S234	5.89	Yes	No	0	9	9
460	R:R:D232	R:R:I253	12.59	Yes	No	0	9	4
461	R:R:V233	R:R:V238	3.21	Yes	Yes	0	7	7
462	R:R:L241	R:R:V233	2.98	Yes	Yes	0	9	7
463	R:R:T257	R:R:V233	3.17	Yes	Yes	0	8	7
464	R:R:R255	R:R:S234	3.95	Yes	No	0	4	9
465	R:R:N256	R:R:Q235	2.64	No	No	0	5	4
466	R:R:T236	R:R:V238	6.35	No	Yes	0	9	7
467	R:R:T236	R:R:T257	3.14	No	Yes	0	9	8
468	R:R:S237	R:R:T259	4.8	No	No	0	4	5
469	R:R:L260	R:R:V238	2.98	Yes	Yes	0	9	7
470	R:R:L241	R:R:P242	3.28	Yes	No	0	9	9
471	R:R:L241	R:R:L252	2.77	Yes	Yes	0	9	9
472	R:R:L241	R:R:L260	5.54	Yes	Yes	0	9	9
473	R:R:E247	R:R:G245	3.27	No	No	0	4	9
474	R:R:E247	R:R:S268	2.87	No	No	0	4	5
475	R:R:L249	R:R:L252	4.15	No	Yes	2	8	9
476	R:R:E251	R:R:R274	4.65	No	Yes	0	5	3
477	R:R:L252	R:R:L277	2.77	Yes	No	0	9	9
478	R:R:D276	R:R:I253	2.8	Yes	No	0	4	4
479	R:R:N256	R:R:R255	3.62	No	Yes	0	5	4
480	R:R:D276	R:R:R255	5.96	Yes	Yes	1	4	4
481	R:R:R255	R:R:T399	2.59	Yes	Yes	1	4	4
482	R:R:L260	R:R:T257	2.95	Yes	Yes	0	9	8
483	R:R:S278	R:R:T257	3.2	No	Yes	0	9	8
484	R:R:W258	R:R:Y279	6.75	No	No	0	4	9
485	R:R:L260	R:R:L263	4.15	Yes	No	0	9	8
486	R:R:I486	R:R:K261	7.27	No	No	0	8	8
487	R:R:D487	R:R:K261	9.68	No	No	0	6	8
488	R:R:K262	R:R:N483	4.2	No	No	0	5	8
489	R:R:L263	R:R:P264	3.28	No	No	0	8	9
490	R:R:H282	R:R:L263	2.57	No	No	0	9	8
491	R:R:F269	R:R:P264	2.89	Yes	No	0	7	9
492	R:R:F269	R:R:S266	2.64	Yes	No	11	7	5
493	R:R:F286	R:R:S266	2.64	Yes	No	11	8	5
494	R:R:N288	R:R:S266	7.45	No	No	0	6	5
495	R:R:F269	R:R:S268	3.96	Yes	No	0	7	5
496	R:R:F269	R:R:L272	4.87	Yes	No	11	7	8
497	R:R:F269	R:R:F286	4.29	Yes	Yes	11	7	8
498	R:R:H271	R:R:L270	7.71	No	No	0	5	3
499	R:R:F286	R:R:L272	3.65	Yes	No	11	8	8
500	R:R:L272	R:R:M396	2.83	No	No	11	8	6
501	R:R:D276	R:R:R274	13.1	Yes	Yes	1	4	3
502	R:R:R274	R:R:V397	9.15	Yes	No	0	3	2
503	R:R:R274	R:R:T399	2.59	Yes	Yes	1	3	4
504	R:R:A275	R:R:L277	4.73	No	No	0	9	9
505	R:R:A275	R:R:F286	4.16	No	Yes	0	9	8
506	R:R:D276	R:R:T399	5.78	Yes	Yes	1	4	4
507	R:R:H282	R:R:Y279	10.89	No	No	0	9	9
508	R:R:I486	R:R:Y279	14.51	No	No	0	8	9
509	R:R:P280	R:R:P400	3.9	No	No	0	8	9
510	R:R:H282	R:R:I281	3.98	No	Yes	0	9	9
511	R:R:A485	R:R:I281	6.5	No	Yes	0	9	9
512	R:R:I281	R:R:I486	2.94	Yes	No	0	9	8
513	R:R:C283	R:R:F286	2.79	No	Yes	0	9	8
514	R:R:C283	R:R:C398	7.28	No	No	0	9	9
515	R:R:C284	R:R:C408	7.28	No	No	0	9	9
516	R:R:A285	R:R:Y482	6.67	No	No	0	8	8
517	R:R:F286	R:R:M396	9.95	Yes	No	11	8	6
518	R:R:N288	R:R:Q289	6.6	No	No	0	6	7
519	R:R:D403	R:R:F405	4.78	No	No	0	8	8
520	R:R:D403	R:R:N406	10.77	No	No	0	8	9
521	R:R:E404	R:R:F405	7	No	No	0	7	8
522	R:R:F405	R:R:V566	2.62	No	Yes	0	8	9
523	R:R:N406	R:R:Q489	5.28	No	No	0	9	9
524	R:R:E409	R:R:P407	6.29	Yes	No	5	9	9
525	R:R:P407	R:R:S657	3.56	No	No	5	9	8
526	R:R:E409	R:R:G413	3.27	Yes	No	0	9	9
527	R:R:E409	R:R:S657	10.06	Yes	No	5	9	8
528	R:R:E409	R:R:K660	8.1	Yes	No	0	9	9
529	R:R:D410	R:R:G413	3.35	Yes	No	0	9	9
530	R:R:D410	R:R:R418	11.91	Yes	No	5	9	9
531	R:R:D410	R:R:D474	3.99	Yes	Yes	5	9	9
532	R:R:D410	R:R:H478	3.78	Yes	No	5	9	5
533	R:R:I411	R:R:V473	3.07	Yes	Yes	5	8	8
534	R:R:D474	R:R:I411	5.6	Yes	Yes	5	9	8
535	R:R:I411	R:R:T477	3.04	Yes	Yes	5	8	9
536	R:R:I411	R:R:Y481	6.04	Yes	Yes	5	8	8
537	R:R:I411	R:R:W488	3.52	Yes	Yes	5	8	9
538	R:R:I411	R:R:S567	6.19	Yes	No	5	8	9
539	R:R:L417	R:R:M412	2.83	Yes	Yes	5	9	8
540	R:R:M412	R:R:V421	7.61	Yes	Yes	5	8	9
541	R:R:I470	R:R:M412	2.92	No	Yes	0	8	8
542	R:R:D474	R:R:M412	9.7	Yes	Yes	5	9	8
543	R:R:M412	R:R:V664	3.04	Yes	Yes	5	8	9
544	R:R:F416	R:R:Y414	5.16	No	Yes	5	6	4
545	R:R:L417	R:R:Y414	5.86	Yes	Yes	5	9	4
546	R:R:S657	R:R:Y414	3.82	No	Yes	5	8	4
547	R:R:N658	R:R:Y414	8.14	Yes	Yes	0	8	4
548	R:R:F416	R:R:L417	8.53	No	Yes	5	6	9
549	R:R:L417	R:R:V664	4.47	Yes	Yes	5	9	9
550	R:R:D474	R:R:R418	10.72	Yes	No	5	9	9
551	R:R:H478	R:R:R418	7.9	No	No	5	5	9
552	R:R:L467	R:R:V421	2.98	Yes	Yes	0	9	9
553	R:R:A471	R:R:V421	5.09	No	Yes	0	9	9
554	R:R:V421	R:R:V664	6.41	Yes	Yes	5	9	9
555	R:R:A471	R:R:W422	9.08	No	No	0	9	9
556	R:R:L475	R:R:W422	4.56	No	No	0	4	9
557	R:R:V424	R:R:V664	3.21	No	Yes	0	9	9
558	R:R:P668	R:R:V424	3.53	No	No	0	9	9
559	R:R:L467	R:R:S425	3	Yes	No	0	9	8
560	R:R:L426	R:R:L430	4.15	No	No	0	6	5
561	R:R:C672	R:R:L427	7.94	No	No	0	9	7
562	R:R:A428	R:R:S671	3.42	No	No	0	9	9
563	R:R:F461	R:R:L429	8.53	No	No	0	5	7
564	R:R:G464	R:R:L429	3.42	No	No	0	9	7
565	R:R:L429	R:R:M465	2.83	No	No	0	7	4
566	R:R:F434	R:R:G431	3.01	No	No	0	7	9
567	R:R:A457	R:R:N432	3.13	No	No	0	9	9
568	R:R:D460	R:R:N432	4.04	Yes	No	0	9	9
569	R:R:N432	R:R:P675	9.77	No	No	0	9	9
570	R:R:F461	R:R:V433	3.93	No	No	0	5	3
571	R:R:F434	R:R:I438	8.79	No	Yes	8	7	8
572	R:R:F434	R:R:F685	5.36	No	Yes	8	7	9
573	R:R:L439	R:R:V435	2.98	No	Yes	0	8	9
574	R:R:A679	R:R:V435	5.09	No	Yes	8	9	9
575	R:R:I680	R:R:V435	3.07	No	Yes	8	9	9
576	R:R:F685	R:R:V435	5.24	Yes	Yes	8	9	9
577	R:R:C454	R:R:L436	3.17	No	No	0	8	5
578	R:R:A457	R:R:L436	3.15	No	No	0	9	5
579	R:R:L437	R:R:T441	2.95	No	No	0	3	7
580	R:R:F685	R:R:I438	12.56	Yes	Yes	8	9	8
581	R:R:D688	R:R:I438	4.2	No	Yes	8	9	8
582	R:R:I438	R:R:V689	4.61	Yes	No	8	8	5
583	R:R:C454	R:R:L439	4.76	No	No	0	8	8
584	R:R:S442	R:R:Y444	5.09	No	No	0	8	7
585	R:R:R450	R:R:S442	3.95	Yes	No	8	9	8
586	R:R:D688	R:R:S442	11.78	No	No	8	9	8
587	R:R:I691	R:R:Y444	3.63	No	No	0	6	7
588	R:R:N447	R:R:P449	13.03	No	Yes	0	8	8
589	R:R:N447	R:R:R450	9.64	No	Yes	0	8	9
590	R:R:P449	R:R:V448	3.53	Yes	Yes	4	8	9
591	R:R:L452	R:R:V448	2.98	Yes	Yes	4	9	9
592	R:R:E518	R:R:V448	9.98	Yes	Yes	4	9	9
593	R:R:I533	R:R:V448	3.07	Yes	Yes	4	5	9
594	R:R:A538	R:R:V448	5.09	No	Yes	0	9	9
595	R:R:E518	R:R:P449	3.14	Yes	Yes	4	9	8
596	R:R:D688	R:R:R450	8.34	No	Yes	8	9	9
597	R:R:F451	R:R:N455	7.25	Yes	Yes	4	9	8
598	R:R:F451	R:R:L535	3.65	Yes	No	4	9	7
599	R:R:A538	R:R:F451	2.77	No	Yes	0	9	9
600	R:R:C539	R:R:F451	5.59	No	Yes	4	4	9
601	R:R:F451	R:R:M542	4.98	Yes	Yes	4	9	9
602	R:R:L452	R:R:V514	5.96	Yes	Yes	4	9	6
603	R:R:I515	R:R:L452	5.71	No	Yes	0	9	9
604	R:R:E518	R:R:L452	2.65	Yes	Yes	4	9	9
605	R:R:L452	R:R:M542	2.83	Yes	Yes	4	9	9
606	R:R:N455	R:R:T511	2.92	Yes	Yes	4	8	9
607	R:R:M542	R:R:N455	14.02	Yes	Yes	4	9	8
608	R:R:N455	R:R:W546	5.65	Yes	Yes	0	8	9
609	R:R:D460	R:R:L456	5.43	Yes	Yes	4	9	9
610	R:R:L456	R:R:T511	5.9	Yes	Yes	4	9	9
611	R:R:L456	R:R:L512	4.15	Yes	Yes	4	9	9
612	R:R:I515	R:R:L456	5.71	No	Yes	0	9	9
613	R:R:L456	R:R:N674	8.24	Yes	Yes	4	9	9
614	R:R:L456	R:R:Y678	3.52	Yes	Yes	4	9	9
615	R:R:C462	R:R:F458	4.19	No	No	0	7	7
616	R:R:F458	R:R:W546	8.02	No	Yes	0	7	9
617	R:R:A459	R:R:L507	4.73	No	Yes	0	9	9
618	R:R:D460	R:R:S508	7.36	Yes	No	0	9	9
619	R:R:D460	R:R:S671	7.36	Yes	No	0	9	9
620	R:R:D460	R:R:N674	8.08	Yes	Yes	4	9	9
621	R:R:M463	R:R:T501	3.01	Yes	Yes	3	9	9
622	R:R:A504	R:R:M463	3.22	No	Yes	0	8	9
623	R:R:M463	R:R:Y667	8.38	Yes	Yes	3	9	9
624	R:R:M463	R:R:S671	6.13	Yes	No	0	9	9
625	R:R:L468	R:R:M465	2.83	No	No	0	7	4
626	R:R:L467	R:R:Y466	3.52	Yes	Yes	0	9	9
627	R:R:I470	R:R:Y466	10.88	No	Yes	0	8	9
628	R:R:A497	R:R:Y466	2.67	No	Yes	0	9	9
629	R:R:T501	R:R:Y466	19.97	Yes	Yes	3	9	9
630	R:R:L570	R:R:Y466	3.52	Yes	Yes	3	9	9
631	R:R:L663	R:R:Y466	5.86	No	Yes	3	9	9
632	R:R:L467	R:R:P668	4.93	Yes	No	0	9	9
633	R:R:L469	R:R:W488	3.42	No	Yes	0	7	9
634	R:R:C569	R:R:I470	3.27	Yes	No	0	9	8
635	R:R:T477	R:R:V473	3.17	Yes	Yes	5	9	8
636	R:R:V473	R:R:W488	13.48	Yes	Yes	5	8	9
637	R:R:H484	R:R:Y476	4.36	Yes	No	0	6	5
638	R:R:T477	R:R:Y481	3.75	Yes	Yes	5	9	8
639	R:R:H484	R:R:T477	9.58	Yes	Yes	0	6	9
640	R:R:H478	R:R:S479	6.97	No	No	0	5	7
641	R:R:E480	R:R:H484	9.85	No	Yes	0	6	6
642	R:R:A485	R:R:Y481	6.67	No	Yes	0	9	8
643	R:R:W488	R:R:Y481	5.79	Yes	Yes	5	9	8
644	R:R:Q489	R:R:Y481	5.64	No	Yes	0	9	8
645	R:R:S567	R:R:Y481	6.36	No	Yes	5	9	8
646	R:R:N483	R:R:Y482	8.14	No	No	0	8	8
647	R:R:G493	R:R:W488	4.22	No	Yes	0	9	9
648	R:R:C494	R:R:W488	6.53	No	Yes	5	9	9
649	R:R:C569	R:R:W488	5.22	Yes	Yes	5	9	9
650	R:R:G491	R:R:P492	4.06	No	No	0	8	3
651	R:R:G493	R:R:T496	3.64	No	No	0	9	5
652	R:R:C494	R:R:C569	7.28	No	Yes	5	9	9
653	R:R:L557	R:R:N495	2.75	No	No	0	7	5
654	R:R:F500	R:R:T496	2.59	No	No	0	7	5
655	R:R:A497	R:R:C569	3.61	No	Yes	0	9	9
656	R:R:G498	R:R:Y563	10.14	No	Yes	0	9	9
657	R:R:F499	R:R:F550	4.29	No	No	0	8	4
658	R:R:A553	R:R:F499	5.55	No	No	0	9	8
659	R:R:L570	R:R:T501	2.95	Yes	Yes	3	9	9
660	R:R:T501	R:R:Y667	6.24	Yes	Yes	3	9	9
661	R:R:E506	R:R:V502	4.28	Yes	Yes	0	8	9
662	R:R:A553	R:R:V502	3.39	No	Yes	0	9	9
663	R:R:V502	R:R:Y563	7.57	Yes	Yes	3	9	9
664	R:R:P571	R:R:V502	3.53	Yes	Yes	3	9	9
665	R:R:F503	R:R:W546	4.01	No	Yes	0	9	9
666	R:R:C549	R:R:F503	2.79	No	No	0	8	9
667	R:R:S505	R:R:Y667	6.36	No	Yes	0	9	9
668	R:R:C549	R:R:E506	4.56	No	Yes	0	8	8
669	R:R:E506	R:R:L552	10.6	Yes	No	0	8	7
670	R:R:E506	R:R:V586	8.56	Yes	No	0	8	7
671	R:R:L507	R:R:T511	2.95	Yes	Yes	0	9	9
672	R:R:L507	R:R:W546	9.11	Yes	Yes	0	9	9
673	R:R:C549	R:R:L507	4.76	No	Yes	0	8	9
674	R:R:N590	R:R:V509	7.39	No	No	0	9	8
675	R:R:V514	R:R:Y510	3.79	Yes	Yes	4	6	7
676	R:R:I541	R:R:Y510	4.84	No	Yes	4	7	7
677	R:R:M542	R:R:Y510	4.79	Yes	Yes	4	9	7
678	R:R:G545	R:R:Y510	10.14	No	Yes	0	9	7
679	R:R:M542	R:R:T511	7.53	Yes	Yes	4	9	9
680	R:R:D633	R:R:L512	4.07	No	Yes	0	8	9
681	R:R:L512	R:R:N674	2.75	Yes	Yes	4	9	9
682	R:R:L512	R:R:Y678	7.03	Yes	Yes	4	9	9
683	R:R:I596	R:R:T513	3.04	No	No	0	6	9
684	R:R:T513	R:R:V597	3.17	No	No	0	9	9
685	R:R:I541	R:R:V514	4.61	No	Yes	4	7	6
686	R:R:M542	R:R:V514	3.04	Yes	Yes	4	9	6
687	R:R:T516	R:R:V597	9.52	No	No	0	9	9
688	R:R:C600	R:R:T516	5.07	No	No	0	9	9
689	R:R:T516	R:R:Y601	12.48	No	Yes	0	9	9
690	R:R:I596	R:R:L517	4.28	No	No	0	6	5
691	R:R:C600	R:R:L517	3.17	No	No	0	9	5
692	R:R:E518	R:R:I533	4.1	Yes	Yes	4	9	5
693	R:R:R519	R:R:Y601	5.14	No	Yes	4	9	9
694	R:R:R519	R:R:Y678	5.14	No	Yes	4	9	9
695	R:R:W520	R:R:Y521	2.89	Yes	Yes	4	7	6
696	R:R:T524	R:R:W520	16.98	No	Yes	4	8	7
697	R:R:F525	R:R:W520	3.01	No	Yes	4	6	7
698	R:R:C600	R:R:W520	3.92	No	Yes	0	9	7
699	R:R:K603	R:R:W520	3.48	No	Yes	0	7	7
700	R:R:F525	R:R:Y521	13.41	No	Yes	4	6	6
701	R:R:R531	R:R:Y521	4.12	No	Yes	0	7	6
702	R:R:I533	R:R:Y521	12.09	Yes	Yes	4	5	6
703	R:R:I523	R:R:I604	7.36	No	No	0	9	9
704	R:R:F525	R:R:T524	6.49	No	No	4	6	8
705	R:R:T524	R:R:T607	3.14	No	No	0	8	7
706	R:R:D530	R:R:R528	8.34	No	No	0	8	7
707	R:R:R528	R:R:R531	5.33	No	No	0	7	7
708	R:R:H537	R:R:I533	2.65	No	Yes	0	7	5
709	R:R:C539	R:R:L535	3.17	No	No	4	4	7
710	R:R:L554	R:R:L557	2.77	No	No	0	5	7
711	R:R:L554	R:R:V558	2.98	No	No	0	5	4
712	R:R:I560	R:R:L555	5.71	No	No	3	7	7
713	R:R:L555	R:R:Y582	4.69	No	Yes	3	7	9
714	R:R:P556	R:R:Y563	16.69	No	Yes	0	9	9
715	R:R:P556	R:R:Y582	11.13	No	Yes	0	9	9
716	R:R:I560	R:R:L578	5.71	No	No	0	7	3
717	R:R:I560	R:R:Y582	3.63	No	Yes	3	7	9
718	R:R:D573	R:R:S561	7.36	Yes	No	3	8	9
719	R:R:A579	R:R:S561	3.42	No	No	3	8	9
720	R:R:S561	R:R:Y582	6.36	No	Yes	3	9	9
721	R:R:K565	R:R:S562	3.06	No	No	0	7	8
722	R:R:D573	R:R:S562	5.89	Yes	No	0	8	8
723	R:R:P571	R:R:Y563	6.95	Yes	Yes	3	9	9
724	R:R:E575	R:R:K565	5.4	No	No	0	4	7
725	R:R:I568	R:R:V566	3.07	Yes	Yes	0	9	9
726	R:R:M572	R:R:V566	9.13	No	Yes	0	9	9
727	R:R:V566	R:R:V656	3.21	Yes	No	0	9	7
728	R:R:K660	R:R:S567	3.06	No	No	0	9	9
729	R:R:I568	R:R:L570	5.71	Yes	Yes	3	9	9
730	R:R:I568	R:R:K660	2.91	Yes	No	0	9	9
731	R:R:I568	R:R:L663	7.14	Yes	No	3	9	9
732	R:R:L570	R:R:M572	4.24	Yes	No	3	9	9
733	R:R:L570	R:R:L663	4.15	Yes	No	3	9	9
734	R:R:L570	W:W:?1	12.43	Yes	Yes	3	9	0
735	R:R:P571	R:R:Y582	2.78	Yes	Yes	3	9	9
736	R:R:P571	W:W:?1	15.8	Yes	Yes	3	9	0
737	R:R:M572	W:W:?1	14.51	No	Yes	3	9	0
738	R:R:D573	R:R:E575	3.9	Yes	No	0	8	4
739	R:R:A579	R:R:D573	4.63	No	Yes	3	8	8
740	R:R:L580	R:R:T574	4.42	No	No	3	4	6
741	R:R:I648	R:R:T574	4.56	Yes	No	3	6	6
742	R:R:P577	R:R:T576	3.5	No	No	0	3	6
743	R:R:I648	R:R:L580	2.85	Yes	No	3	6	4
744	R:R:I583	R:R:L587	2.85	No	Yes	3	7	8
745	R:R:I583	R:R:I648	4.42	No	Yes	3	7	6
746	R:R:I583	W:W:?1	9.16	No	Yes	3	7	0
747	R:R:F585	R:R:L589	8.53	No	No	0	4	3
748	R:R:V586	W:W:?1	5.74	No	Yes	0	7	0
749	R:R:A644	R:R:L587	4.73	No	Yes	3	9	8
750	R:R:L587	R:R:L645	2.77	Yes	No	0	8	7
751	R:R:L587	W:W:?1	2.66	Yes	Yes	3	8	0
752	R:R:C598	R:R:F594	2.79	No	Yes	0	7	8
753	R:R:D633	R:R:F594	5.97	No	Yes	0	8	8
754	R:R:F594	R:R:F634	6.43	Yes	No	0	8	9
755	R:R:F594	R:R:M637	7.46	Yes	No	0	8	7
756	R:R:C598	R:R:I630	4.91	No	No	0	7	9
757	R:R:M626	R:R:Y601	8.38	No	Yes	0	9	9
758	R:R:L629	R:R:Y601	7.03	No	Yes	4	9	9
759	R:R:I630	R:R:Y601	6.04	No	Yes	0	9	9
760	R:R:Y601	R:R:Y678	2.98	Yes	Yes	4	9	9
761	R:R:I606	R:R:V602	3.07	No	No	0	3	4
762	R:R:I604	R:R:M626	2.92	No	No	0	9	9
763	R:R:R609	R:R:Y605	8.23	No	Yes	17	7	9
764	R:R:D619	R:R:Y605	6.9	No	Yes	17	9	9
765	R:R:I622	R:R:Y605	4.84	No	Yes	0	8	9
766	R:R:A623	R:R:Y605	4	No	Yes	0	9	9
767	R:R:M626	R:R:Y605	4.79	No	Yes	0	9	9
768	R:R:I622	R:R:V608	3.07	No	No	0	8	9
769	R:R:D619	R:R:R609	9.53	No	No	17	9	7
770	R:R:N610	R:R:P611	6.52	No	No	0	6	8
771	R:R:K618	R:R:N610	2.8	No	No	0	6	6
772	R:R:D617	R:R:T620	5.78	No	No	0	6	7
773	R:R:D617	R:R:K621	6.91	No	No	0	6	6
774	R:R:L629	R:R:L677	5.54	No	No	0	9	9
775	R:R:L629	R:R:Y678	8.21	No	Yes	4	9	9
776	R:R:F631	R:R:I635	10.05	No	No	0	8	6
777	R:R:L669	R:R:T632	2.95	No	Yes	0	8	9
778	R:R:L677	R:R:T632	4.42	No	Yes	0	9	9
779	R:R:D633	R:R:N670	8.08	No	No	0	8	9
780	R:R:A638	R:R:F634	8.32	No	No	0	8	9
781	R:R:I635	R:R:L669	2.85	No	No	0	6	8
782	R:R:C636	R:R:L669	4.76	No	No	0	9	8
783	R:R:C636	R:R:N670	11.02	No	No	0	9	9
784	R:R:M637	R:R:S641	4.6	No	No	0	7	9
785	R:R:I640	R:R:Y667	4.84	No	Yes	3	9	9
786	R:R:I640	W:W:?1	7.33	No	Yes	3	9	0
787	R:R:F642	R:R:Y643	9.28	No	Yes	0	9	8
788	R:R:I654	R:R:Y643	16.92	Yes	Yes	3	9	8
789	R:R:L662	R:R:Y643	3.52	No	Yes	3	8	8
790	R:R:A644	W:W:?1	3.03	No	Yes	3	9	0
791	R:R:A647	W:W:?1	6.07	No	Yes	0	9	0
792	R:R:I648	W:W:?1	3.66	Yes	Yes	3	6	0
793	R:R:P652	W:W:?1	3.16	No	Yes	0	9	0
794	R:R:I654	R:R:N658	2.83	Yes	Yes	0	9	8
795	R:R:I654	R:R:L662	2.85	Yes	No	3	9	8
796	R:R:I654	W:W:?1	2.75	Yes	Yes	3	9	0
797	R:R:N658	R:R:T655	4.39	Yes	No	0	8	8
798	R:R:V656	W:W:?1	5.74	No	Yes	0	7	0
799	R:R:I661	R:R:N658	2.83	No	Yes	0	9	8
800	R:R:S659	W:W:?1	9.63	No	Yes	0	9	0
801	R:R:I661	R:R:L665	2.85	No	No	0	9	8
802	R:R:L662	W:W:?1	4.44	No	Yes	3	8	0
803	R:R:F666	R:R:L665	3.65	No	No	0	8	8
804	R:R:P668	R:R:Y667	4.17	No	Yes	0	9	9
805	R:R:Y667	W:W:?1	3.01	Yes	Yes	3	9	0
806	R:R:N670	R:R:N674	8.17	No	Yes	0	9	9
807	R:R:N674	R:R:Y678	5.81	Yes	Yes	4	9	9
808	R:R:F676	R:R:I680	11.3	No	No	0	8	9
809	R:R:F676	R:R:F681	6.43	No	No	0	8	8
810	R:R:A679	R:R:F685	2.77	No	Yes	8	9	9
811	R:R:F685	R:R:I680	6.28	Yes	No	8	9	9
812	R:R:F685	R:R:T682	2.59	Yes	No	0	9	9
813	R:R:A684	R:R:R687	4.15	No	No	0	8	7
814	R:R:F685	R:R:V689	3.93	Yes	No	8	9	5
815	R:R:K695	R:R:S694	4.59	No	No	0	8	8
816	N:N:Q1	N:N:S25	5.78	No	No	0	0	0
817	N:N:V2	N:N:Y27	5.05	No	Yes	1	0	0
818	N:N:R98	N:N:V2	2.62	Yes	No	1	0	0
819	N:N:N110	N:N:V2	10.35	Yes	No	1	0	0
820	N:N:Q3	N:N:V5	4.3	No	No	0	0	0
821	N:N:L4	N:N:Y27	3.52	No	Yes	0	0	0
822	N:N:C96	N:N:L4	3.17	Yes	No	0	0	0
823	N:N:L4	N:N:N110	2.75	No	Yes	0	0	0
824	N:N:C22	N:N:Q6	3.05	No	Yes	7	0	0
825	N:N:Q6	N:N:W36	3.29	Yes	Yes	7	0	0
826	N:N:C96	N:N:Q6	7.63	Yes	Yes	7	0	0
827	N:N:G112	N:N:Q6	4.93	No	Yes	0	0	0
828	N:N:Q113	N:N:Q6	7.68	No	Yes	0	0	0
829	N:N:G114	N:N:Q6	4.93	No	Yes	0	0	0
830	N:N:Q6	N:N:T115	7.09	Yes	No	7	0	0
831	N:N:I20	N:N:S7	4.64	Yes	No	7	0	0
832	N:N:S21	N:N:S7	4.89	No	No	0	0	0
833	N:N:S7	N:N:T115	6.4	No	No	7	0	0
834	N:N:K12	N:N:L86	2.82	No	Yes	0	0	0
835	N:N:P14	N:N:V119	5.3	No	No	0	0	0
836	N:N:I20	N:N:L18	4.28	Yes	Yes	7	0	0
837	N:N:L18	N:N:W83	4.56	Yes	Yes	7	0	0
838	N:N:L18	N:N:L86	4.15	Yes	Yes	7	0	0
839	N:N:L18	N:N:V117	4.47	Yes	No	0	0	0
840	N:N:K19	N:N:Y80	9.55	No	Yes	0	0	0
841	N:N:K19	N:N:Q82	5.42	No	No	0	0	0
842	N:N:I20	N:N:L81	7.14	Yes	Yes	7	0	0
843	N:N:I20	N:N:Y94	3.63	Yes	Yes	7	0	0
844	N:N:I20	N:N:T115	9.12	Yes	No	7	0	0
845	N:N:C22	N:N:W36	2.61	No	Yes	7	0	0
846	N:N:C22	N:N:C96	7.28	No	Yes	7	0	0
847	N:N:R23	N:N:T78	5.17	No	No	0	0	0
848	N:N:G24	N:N:Y27	2.9	No	Yes	0	0	0
849	N:N:F29	N:N:Y27	3.09	Yes	Yes	0	0	0
850	N:N:Y27	N:N:Y32	5.96	Yes	Yes	1	0	0
851	N:N:R98	N:N:Y27	18.52	Yes	Yes	1	0	0
852	N:N:R28	N:N:T30	7.76	No	No	0	0	0
853	N:N:R28	N:N:S31	9.22	No	No	0	0	0
854	N:N:F29	N:N:I34	5.02	Yes	No	0	0	0
855	N:N:F29	N:N:P53	10.11	Yes	No	0	0	0
856	N:N:A72	N:N:F29	2.77	No	Yes	0	0	0
857	N:N:F29	N:N:N77	8.46	Yes	No	0	0	0
858	N:N:K74	N:N:T30	3	No	No	0	0	0
859	N:N:R98	N:N:Y32	21.61	Yes	Yes	1	0	0
860	N:N:E100	N:N:Y32	6.73	Yes	Yes	1	0	0
861	N:N:P101	N:N:Y32	2.78	Yes	Yes	1	0	0
862	N:N:R50	N:N:W33	29.99	Yes	Yes	0	0	0
863	N:N:D52	N:N:W33	10.05	Yes	Yes	0	0	0
864	N:N:W33	N:N:Y57	5.79	Yes	Yes	0	0	0
865	N:N:L99	N:N:W33	5.69	Yes	Yes	0	0	0
866	N:N:A79	N:N:I34	4.87	No	No	0	0	0
867	N:N:N35	N:N:W47	7.91	Yes	Yes	1	0	0
868	N:N:N35	N:N:R50	3.62	Yes	Yes	1	0	0
869	N:N:L99	N:N:N35	5.49	Yes	Yes	1	0	0
870	N:N:N35	N:N:S108	2.98	Yes	Yes	1	0	0
871	N:N:L81	N:N:W36	18.22	Yes	Yes	7	0	0
872	N:N:C96	N:N:W36	7.84	Yes	Yes	7	0	0
873	N:N:L45	N:N:V37	4.47	Yes	No	1	0	0
874	N:N:V37	N:N:W111	4.9	No	Yes	1	0	0
875	N:N:F64	N:N:R38	13.9	No	No	0	0	0
876	N:N:R38	N:N:Y94	19.55	No	Yes	0	0	0
877	N:N:L45	N:N:Q39	5.32	Yes	No	1	0	0
878	N:N:L40	N:N:P41	4.93	No	No	0	0	0
879	N:N:G49	N:N:W47	7.04	No	Yes	0	0	0
880	N:N:M48	N:N:V68	4.56	Yes	No	7	0	0
881	N:N:L81	N:N:M48	8.48	Yes	Yes	7	0	0
882	N:N:M48	N:N:W83	3.49	Yes	Yes	7	0	0
883	N:N:M48	N:N:Y94	4.79	Yes	Yes	7	0	0
884	N:N:N59	N:N:R50	7.23	No	Yes	1	0	0
885	N:N:R50	N:N:Y103	7.2	Yes	Yes	1	0	0
886	N:N:I51	N:N:T58	4.56	No	Yes	12	0	0
887	N:N:I51	N:N:V70	4.61	No	No	12	0	0
888	N:N:D52	N:N:P53	6.44	Yes	No	0	0	0
889	N:N:D52	N:N:T54	7.23	Yes	Yes	1	0	0
890	N:N:D52	N:N:D55	2.66	Yes	Yes	1	0	0
891	N:N:D55	N:N:T54	5.78	Yes	Yes	1	0	0
892	N:N:N59	N:N:Y57	12.79	No	Yes	1	0	0
893	N:N:Y103	N:N:Y57	4.96	Yes	Yes	1	0	0
894	N:N:T58	N:N:Y60	11.24	Yes	No	12	0	0
895	N:N:T58	N:N:V70	3.17	Yes	No	12	0	0
896	N:N:N59	N:N:Y103	5.81	No	Yes	1	0	0
897	N:N:K65	N:N:Y60	4.78	No	No	0	0	0
898	N:N:V70	N:N:Y60	6.31	No	No	12	0	0
899	N:N:P62	N:N:S61	3.56	No	No	0	0	0
900	N:N:S61	N:N:S63	4.89	No	No	13	0	0
901	N:N:F64	N:N:S61	5.28	No	No	13	0	0
902	N:N:F64	N:N:S63	13.21	No	No	13	0	0
903	N:N:L81	N:N:V68	2.98	Yes	No	7	0	0
904	N:N:V68	N:N:W83	7.36	No	Yes	7	0	0
905	N:N:Q82	N:N:T69	5.67	No	No	0	0	0
906	N:N:S71	N:N:Y80	3.82	No	Yes	0	0	0
907	N:N:D73	N:N:S75	7.36	No	No	18	0	0
908	N:N:D73	N:N:I76	7	No	No	18	0	0
909	N:N:I76	N:N:S75	7.74	No	No	18	0	0
910	N:N:I76	N:N:T78	6.08	No	No	0	0	0
911	N:N:T78	N:N:Y80	9.99	No	Yes	0	0	0
912	N:N:L86	N:N:W83	11.39	Yes	Yes	7	0	0
913	N:N:D90	N:N:W83	14.52	No	Yes	7	0	0
914	N:N:W83	N:N:Y94	6.75	Yes	Yes	7	0	0
915	N:N:D90	N:N:L86	5.43	No	Yes	7	0	0
916	N:N:L86	N:N:V119	4.47	Yes	No	0	0	0
917	N:N:D90	N:N:K87	5.53	No	No	0	0	0
918	N:N:M93	N:N:Y95	9.58	No	Yes	0	0	0
919	N:N:L116	N:N:M93	5.65	No	No	0	0	0
920	N:N:G114	N:N:Y95	5.79	No	Yes	0	0	0
921	N:N:A97	N:N:S108	3.42	No	Yes	1	0	0
922	N:N:A97	N:N:W111	9.08	No	Yes	1	0	0
923	N:N:E100	N:N:R98	5.82	Yes	Yes	1	0	0
924	N:N:N110	N:N:R98	4.82	Yes	Yes	1	0	0
925	N:N:L99	N:N:S105	9.01	Yes	No	0	0	0
926	N:N:L99	N:N:S108	6.01	Yes	Yes	1	0	0
927	N:N:E100	N:N:P101	3.14	Yes	Yes	1	0	0
928	N:N:E100	N:N:W107	15.27	Yes	Yes	1	0	0
929	N:N:E100	N:N:V109	5.7	Yes	No	0	0	0
930	N:N:S108	N:N:W111	3.71	Yes	Yes	1	0	0
931	N:N:N110	N:N:V109	2.96	Yes	No	0	0	0
932	R:R:H484	R:R:N483	2.55	Yes	No	0	6	8
933	R:R:S646	R:R:Y643	2.54	No	Yes	0	9	8
934	N:N:S21	N:N:Y80	2.54	No	Yes	0	0	0
935	R:R:F423	R:R:I419	2.51	No	No	0	5	6
936	R:R:F696	R:R:K695	2.48	No	No	0	4	8
937	R:R:F676	R:R:L427	2.44	No	No	0	8	7
938	R:R:F585	R:R:L552	2.44	No	No	0	4	7
939	R:R:F642	R:R:L653	2.44	No	No	0	9	9
940	R:R:F696	R:R:L692	2.44	No	No	0	4	8
941	R:R:L446	R:R:R450	2.43	No	Yes	0	6	9
942	R:R:D203	R:R:F153	2.39	No	Yes	0	6	5
943	R:R:L557	R:R:Y563	2.34	No	Yes	0	7	9
944	N:N:E46	N:N:R38	2.33	No	No	0	0	0
945	R:R:L468	R:R:W422	2.28	No	No	0	7	9
946	R:R:H537	R:R:R534	2.26	No	No	0	7	7
947	R:R:R534	R:R:R536	2.13	No	No	0	7	5
948	L:L:G103	L:L:G104	2.11	No	No	0	0	0
949	L:L:G104	L:L:G105	2.11	No	No	0	0	0
950	R:R:G544	R:R:G545	2.11	No	No	0	3	9
951	L:L:P7	L:L:P8	1.95	Yes	No	0	0	0
952	R:R:P51	R:R:P52	1.95	Yes	No	0	5	3
953	L:L:A14	L:L:P15	1.87	No	No	0	0	0
954	R:R:A638	R:R:P639	1.87	No	No	0	8	9
955	L:L:G13	L:L:S12	1.86	No	No	0	0	0
956	L:L:G25	L:L:S24	1.86	No	No	0	0	0
957	L:L:G66	L:L:S65	1.86	No	No	0	0	0
958	N:N:G15	N:N:S85	1.86	No	No	0	0	0
959	N:N:G26	N:N:S25	1.86	No	No	0	0	0
960	L:L:G104	L:L:V3	1.84	No	No	0	0	0
961	R:R:G137	R:R:T115	1.82	No	No	0	8	4
962	N:N:G92	N:N:T91	1.82	No	No	0	0	0
963	R:R:P126	R:R:S101	1.78	No	No	0	5	4
964	R:R:P264	R:R:S243	1.78	No	No	0	9	5
965	R:R:P280	R:R:S402	1.78	No	No	0	8	9
966	L:L:P15	L:L:V110	1.77	No	No	0	0	0
967	L:L:G25	L:L:I30	1.76	No	Yes	0	0	0
968	R:R:P400	R:R:T399	1.75	No	Yes	0	9	4
969	N:N:G44	N:N:K43	1.74	No	No	0	0	0
970	L:L:A76	L:L:S65	1.71	No	No	0	0	0
971	R:R:A564	R:R:S562	1.71	No	No	0	7	8
972	N:N:G92	N:N:L40	1.71	No	No	0	0	0
973	R:R:G188	R:R:N187	1.7	No	Yes	0	6	9
974	R:R:A220	R:R:V192	1.7	No	Yes	0	8	7
975	R:R:A254	R:R:V233	1.7	No	Yes	0	8	7
976	R:R:A593	R:R:V509	1.7	No	No	0	9	8
977	R:R:M140	R:R:P168	1.68	No	Yes	0	1	6
978	R:R:M453	R:R:P449	1.68	No	Yes	0	7	8
979	R:R:A593	R:R:T513	1.68	No	No	0	9	9
980	R:R:A579	R:R:T576	1.68	No	No	0	8	6
981	R:R:A673	R:R:T632	1.68	No	Yes	0	9	9
982	R:R:A684	R:R:T682	1.68	No	No	0	8	9
983	R:R:K651	R:R:P652	1.67	No	No	0	4	9
984	N:N:K13	N:N:P14	1.67	No	No	0	0	0
985	L:L:L80	L:L:P15	1.64	Yes	No	0	0	0
986	R:R:L125	R:R:P126	1.64	No	No	0	8	5
987	R:R:C408	R:R:I281	1.64	No	Yes	0	9	9
988	R:R:N161	R:R:P162	1.63	Yes	No	0	8	7
989	N:N:S84	N:N:S85	1.63	No	No	0	0	0
990	R:R:S472	R:R:V473	1.62	No	Yes	0	8	8
991	L:L:S27	L:L:T71	1.6	No	No	0	0	0
992	R:R:S191	R:R:T190	1.6	No	No	0	4	5
993	R:R:S237	R:R:T214	1.6	No	No	0	4	4
994	R:R:V420	R:R:V664	1.6	No	Yes	0	6	9
995	R:R:C454	R:R:L440	1.59	No	No	0	8	6
996	R:R:T588	R:R:V584	1.59	No	No	0	3	5
997	R:R:T588	R:R:V592	1.59	No	No	0	3	3
998	R:R:T632	R:R:V628	1.59	Yes	No	0	9	6
999	N:N:T118	N:N:V11	1.59	No	No	0	0	0
1000	N:N:T91	N:N:V119	1.59	No	No	0	0	0
1001	R:R:P168	R:R:Q193	1.58	Yes	No	0	6	5
1002	N:N:A9	N:N:L116	1.58	No	No	0	0	0
1003	R:R:T214	R:R:T239	1.57	No	No	0	4	4
1004	R:R:T257	R:R:T259	1.57	Yes	No	0	8	5
1005	R:R:I648	R:R:V584	1.54	Yes	No	0	6	5
1006	R:R:I596	R:R:V592	1.54	No	No	0	6	3
1007	R:R:K250	R:R:S229	1.53	No	No	0	7	5
1008	R:R:K244	R:R:S243	1.53	No	No	0	3	5
1009	N:N:K87	N:N:S89	1.53	No	No	0	0	0
1010	R:R:A522	R:R:E518	1.51	No	Yes	0	8	9
1011	L:L:G31	L:L:R68	1.5	No	No	0	0	0
1012	L:L:G79	L:L:R78	1.5	No	No	0	0	0
1013	R:R:K250	R:R:T273	1.5	No	No	0	7	4
1014	R:R:L426	R:R:S425	1.5	No	No	0	6	8
1015	R:R:N74	R:R:S73	1.49	No	No	0	4	4
1016	R:R:L551	R:R:V547	1.49	No	No	0	2	3
1017	R:R:L127	R:R:T150	1.47	No	No	0	4	3
1018	R:R:L692	R:R:T441	1.47	No	No	0	8	7
1019	R:R:I591	R:R:M637	1.46	No	No	0	6	7
1020	R:R:I419	R:R:K415	1.45	No	No	0	6	3
1021	R:R:D619	R:R:T620	1.45	No	No	0	9	7
1022	R:R:K287	R:R:K290	1.44	No	No	0	5	5
1023	N:N:Q3	N:N:S25	1.44	No	No	0	0	0
1024	R:R:I438	R:R:L692	1.43	Yes	No	0	8	8
1025	R:R:I648	R:R:L649	1.43	Yes	No	0	6	5
1026	R:R:L267	R:R:N288	1.37	No	No	0	5	6
1027	L:L:D62	R:R:N256	1.35	No	No	0	0	5
1028	N:N:E10	N:N:L18	1.33	No	Yes	0	0	0
1029	R:R:H443	R:R:K695	1.31	No	No	0	5	8
1030	L:L:R18	L:L:T20	1.29	No	No	0	0	0
1031	R:R:Q90	R:R:Q91	1.28	No	No	0	4	3
1032	R:R:H63	R:R:Q45	1.24	No	No	0	4	4
1033	R:R:K139	R:R:Y163	1.19	No	No	0	4	4
1034	R:R:L265	R:R:Y482	1.17	No	No	0	7	8
1035	R:R:F681	R:R:Q686	1.17	No	No	0	8	7
1036	R:R:F690	R:R:Q686	1.17	No	No	0	5	7
1037	R:R:H32	R:R:R38	1.13	No	Yes	0	5	4

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	L:L:L4	4.29	7	6	0
2	L:L:Q6	5.572	5	6	0
3	L:L:P7	3.4375	4	6	0
4	L:L:I21	4.9725	4	6	0
5	L:L:N29	5.17143	7	6	0
6	L:L:I30	4.188	5	6	0
7	L:L:N32	8.18	4	1	0
8	L:L:N33	7.026	5	1	0
9	L:L:W37	6.786	5	6	0
10	L:L:Y38	7.6825	4	1	0
11	L:L:Q39	7.052	5	1	0
12	L:L:L41	3.6425	4	1	0
13	L:L:L48	6.3075	4	1	0
14	L:L:L49	6.765	4	1	0
15	L:L:Y51	8.785	6	1	0
16	L:L:Q55	7.6625	4	0	0
17	L:L:L56	6.58	4	1	0
18	L:L:P57	6.38	4	1	0
19	L:L:V60	4.985	4	1	0
20	L:L:R63	8.865	4	1	0
21	L:L:F64	5.66286	7	1	0
22	L:L:L75	6.6975	4	0	0
23	L:L:I77	4.45	4	1	0
24	L:L:L80	2.862	5	1	0
25	L:L:D84	5.59	4	1	0
26	L:L:Y88	6.7	5	1	0
27	L:L:Y89	7.308	5	1	0
28	L:L:C90	6.75	4	6	0
29	L:L:T91	5.605	4	1	0
30	L:L:W93	5.37429	7	1	0
31	L:L:D94	7.222	5	6	0
32	L:L:D95	6.616	5	1	0
33	L:L:Q100	12.0925	4	1	0
34	L:L:L101	3.48	4	6	0
35	L:L:F102	8.36	4	1	0
36	L:L:T106	5.3975	4	6	0
37	R:R:F37	6.56833	6	2	1
38	R:R:R38	8.19	5	0	4
39	R:R:V39	4.4775	4	2	6
40	R:R:I44	4.148	5	2	5
41	R:R:I47	3.9075	4	2	4
42	R:R:L50	4.218	5	2	5
43	R:R:P51	4.4	4	2	5
44	R:R:T54	4.91	4	2	7
45	R:R:K58	7.6325	4	1	5
46	R:R:T62	5.1575	4	2	7
47	R:R:L64	3.95	5	2	6
48	R:R:I67	4.364	5	2	5
49	R:R:H70	6.3675	4	9	4
50	R:R:F72	5.64	4	2	9
51	R:R:R80	9.13375	8	1	4
52	R:R:I81	4.35	4	2	8
53	R:R:I85	5.9575	4	1	6
54	R:R:D86	4.905	4	2	8
55	R:R:L89	4.5225	4	2	8
56	R:R:L92	4.6525	4	2	8
57	R:R:H95	9.8	4	9	5
58	R:R:S96	3.8125	4	2	7
59	R:R:Y98	10.4217	6	9	2
60	R:R:H105	7.874	5	1	7
61	R:R:E107	8.035	4	1	6
62	R:R:R109	9.494	5	1	5
63	R:R:T111	3.7675	4	2	5
64	R:R:L114	4.605	4	2	8
65	R:R:D118	6.0925	4	15	5
66	R:R:K123	8.8575	4	9	4
67	R:R:L128	4.11333	6	2	9
68	R:R:F130	4.94333	6	1	6
69	R:R:L131	3.87333	6	2	8
70	R:R:I133	3.88	5	2	8
71	R:R:F134	6.614	5	1	5
72	R:R:T136	6.38	5	2	9
73	R:R:F141	4.76286	7	2	7
74	R:R:P142	4.37	4	0	9
75	R:R:L144	4.6275	4	0	7
76	R:R:F153	4.53333	6	1	5
77	R:R:F154	5.63667	6	2	6
78	R:R:I155	4.6075	4	1	5
79	R:R:E157	6.532	5	1	8
80	R:R:I158	4.42143	7	2	7
81	R:R:T159	6.42	4	1	5
82	R:R:N161	5.68833	6	2	8
83	R:R:M164	5.332	5	2	7
84	R:R:I167	4.8275	4	2	7
85	R:R:P168	3.812	5	2	6
86	R:R:N170	8.56	4	10	8
87	R:R:F172	5.198	5	2	8
88	R:R:Q173	6.2125	4	10	2
89	R:R:L175	6.32	4	2	7
90	R:R:L180	4.194	5	2	7
91	R:R:L182	4.68667	6	2	6
92	R:R:K183	6.9275	4	1	6
93	R:R:Y185	7.67	6	1	7
94	R:R:N187	6.552	5	2	9
95	R:R:F189	7.724	5	2	8
96	R:R:V192	2.996	5	0	7
97	R:R:F197	6.588	5	0	9
98	R:R:N198	7.902	5	10	7
99	R:R:L202	4.78	5	2	8
100	R:R:V205	3.686	5	2	7
101	R:R:Y206	6.184	5	1	6
102	R:R:L207	2.875	4	0	7
103	R:R:N208	11.2525	4	1	5
104	R:R:L213	2.87	4	0	9
105	R:R:F221	7.924	5	2	9
106	R:R:P228	4.1625	4	2	8
107	R:R:L230	5.755	4	1	4
108	R:R:L231	3.152	5	2	7
109	R:R:D232	10.0975	4	1	9
110	R:R:V233	3.085	6	0	7
111	R:R:V238	3.718	5	0	7
112	R:R:L241	3.6425	4	0	9
113	R:R:L252	3.115	4	2	9
114	R:R:R255	5.168	5	1	4
115	R:R:T257	2.806	5	0	8
116	R:R:L260	3.905	4	0	9
117	R:R:F269	3.73	5	11	7
118	R:R:R274	6.29333	6	1	3
119	R:R:D276	6.706	5	1	4
120	R:R:I281	3.765	4	0	9
121	R:R:F286	4.58	6	11	8
122	R:R:T399	3.1775	4	1	4
123	R:R:E409	6.93	4	5	9
124	R:R:D410	5.7575	4	5	9
125	R:R:I411	4.57667	6	5	8
126	R:R:M412	5.22	5	5	8
127	R:R:Y414	5.745	4	5	4
128	R:R:L417	5.4225	4	5	9
129	R:R:V421	5.5225	4	5	9
130	R:R:V435	4.095	4	8	9
131	R:R:I438	6.318	5	8	8
132	R:R:V448	4.93	5	4	9
133	R:R:P449	5.345	4	4	8
134	R:R:R450	6.09	4	8	9
135	R:R:F451	4.848	5	4	9
136	R:R:L452	4.026	5	4	9
137	R:R:N455	7.46	4	4	8
138	R:R:L456	5.49167	6	4	9
139	R:R:D460	6.454	5	4	9
140	R:R:M463	5.185	4	3	9
141	R:R:Y466	7.73667	6	3	9
142	R:R:L467	3.6075	4	0	9
143	R:R:V473	5.335	4	5	8
144	R:R:D474	7.5025	4	5	9
145	R:R:T477	4.885	4	5	9
146	R:R:Y481	5.70833	6	5	8
147	R:R:H484	6.585	4	0	6
148	R:R:W488	6.02571	7	5	9
149	R:R:T501	8.0425	4	3	9
150	R:R:V502	4.6925	4	3	9
151	R:R:E506	7	4	0	8
152	R:R:L507	5.3875	4	0	9
153	R:R:Y510	5.89	4	4	7
154	R:R:T511	4.825	4	4	9
155	R:R:L512	4.5	4	4	9
156	R:R:V514	4.35	4	4	6
157	R:R:E518	4.276	5	4	9
158	R:R:W520	6.056	5	4	7
159	R:R:Y521	8.1275	4	4	6
160	R:R:I533	5.4775	4	4	5
161	R:R:M542	6.19833	6	4	9
162	R:R:W546	6.6975	4	0	9
163	R:R:Y563	8.738	5	3	9
164	R:R:V566	4.5075	4	0	9
165	R:R:I568	4.7075	4	3	9
166	R:R:C569	4.845	4	5	9
167	R:R:L570	5.5	6	3	9
168	R:R:P571	7.265	4	3	9
169	R:R:D573	5.445	4	3	8
170	R:R:Y582	5.718	5	3	9
171	R:R:L587	3.2525	4	3	8
172	R:R:F594	5.6625	4	0	8
173	R:R:Y601	7.00833	6	4	9
174	R:R:Y605	5.752	5	17	9
175	R:R:T632	2.66	4	0	9
176	R:R:Y643	8.065	4	3	8
177	R:R:I648	3.07667	6	3	6
178	R:R:I654	6.3375	4	3	9
179	R:R:N658	4.5475	4	0	8
180	R:R:V664	3.746	5	5	9
181	R:R:Y667	5.5	6	3	9
182	R:R:N674	6.61	5	4	9
183	R:R:Y678	5.44833	6	4	9
184	R:R:F685	5.53286	7	8	9
185	N:N:Q6	5.51429	7	7	0
186	N:N:L18	3.758	5	7	0
187	N:N:I20	5.762	5	7	0
188	N:N:Y27	6.50667	6	1	0
189	N:N:F29	5.89	5	0	0
190	N:N:Y32	8.242	5	1	0
191	N:N:W33	12.88	4	0	0
192	N:N:N35	5.32	5	1	0
193	N:N:W36	7.99	4	7	0
194	N:N:L45	9.8875	4	1	0
195	N:N:W47	8.702	5	1	0
196	N:N:M48	5.33	4	7	0
197	N:N:R50	12.008	5	1	0
198	N:N:D52	7.23333	6	1	0
199	N:N:T54	4.58167	6	1	0
200	N:N:D55	7.225	4	1	0
201	N:N:Y57	9.852	5	1	0
202	N:N:T58	6.86	4	12	0
203	N:N:Y80	6.475	4	0	0
204	N:N:L81	9.205	4	7	0
205	N:N:W83	8.01167	6	7	0
206	N:N:L86	5.652	5	7	0
207	N:N:Y94	8.68	4	7	0
208	N:N:Y95	6.766	5	1	0
209	N:N:C96	6.48	4	7	0
210	N:N:R98	10.678	5	1	0
211	N:N:L99	6.55	4	1	0
212	N:N:E100	7.235	6	1	0
213	N:N:P101	4.195	4	1	0
214	N:N:Y103	7.04625	8	1	0
215	N:N:W107	9.57857	7	1	0
216	N:N:S108	3.988	5	1	0
217	N:N:N110	5.22	4	1	0
218	N:N:W111	7.126	5	1	0
219	W:W:?1	6.82	16	3	0
220	H:H:?1	13.17	4	10	0
221	H:H:?2	11.915	4	16	0

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:Y89	N:N:L45	10.8438	17.58	Yes	Yes	1	0	0
2	L:L:F102	N:N:L45	10.4257	12.18	Yes	Yes	1	0	0
3	L:L:F102	L:L:Q100	11.0924	8.2	Yes	Yes	1	0	0
4	L:L:L48	L:L:Y38	10.2935	9.38	Yes	Yes	1	0	0
5	L:L:Y38	N:N:S108	10.5619	3.82	Yes	Yes	1	0	0
6	L:L:W93	N:N:W47	10.5042	2.81	Yes	Yes	1	0	0
7	L:L:W93	N:N:Y103	11.7909	6.75	Yes	Yes	1	0	0
8	N:N:Y103	N:N:Y57	25.6807	4.96	Yes	Yes	1	0	0
9	N:N:Y57	R:R:R38	71.6892	17.49	Yes	Yes	0	0	4
10	R:R:D36	R:R:R38	86.4215	3.57	No	Yes	0	3	4
11	R:R:D36	R:R:Q55	86.5425	15.66	No	No	0	3	4
12	H:H:?4	R:R:Q55	86.6469	5.97	No	No	14	0	4
13	H:H:?4	R:R:S53	86.9053	4.04	No	No	0	0	5
14	R:R:F37	R:R:S53	87.0261	11.89	Yes	No	0	1	5
15	R:R:F37	R:R:T54	85.0701	3.89	Yes	Yes	2	1	7
16	R:R:R80	R:R:T56	13.538	3.88	Yes	No	0	4	5
17	N:N:Y57	R:R:R80	13.5523	8.23	Yes	Yes	1	0	4
18	R:R:R38	R:R:T56	13.6529	12.94	Yes	No	0	4	5
19	R:R:L75	R:R:T54	85.7224	5.9	No	Yes	0	6	7
20	R:R:I78	R:R:L75	86.5138	5.71	No	No	0	7	6
21	R:R:I78	R:R:I81	86.632	4.42	No	Yes	0	7	8
22	N:N:L99	N:N:W33	20.2087	5.69	Yes	Yes	0	0	0
23	R:R:H105	R:R:R80	10.8049	16.93	Yes	Yes	1	7	4
24	R:R:I106	R:R:I81	87.1321	2.94	No	Yes	2	7	8
25	R:R:F130	R:R:H105	10.3528	7.92	Yes	Yes	1	6	7
26	R:R:I106	R:R:L131	85.5704	4.28	No	Yes	2	7	8
27	R:R:I133	R:R:L131	85.1752	2.85	Yes	Yes	2	8	8
28	R:R:I133	R:R:I158	70.6417	2.94	Yes	Yes	2	8	7
29	R:R:I133	R:R:N161	14.1334	5.66	Yes	Yes	2	8	8
30	R:R:F154	R:R:L180	11.81	4.87	Yes	Yes	2	6	7
31	R:R:I158	R:R:N187	14.0968	5.66	Yes	Yes	2	7	9
32	R:R:N161	R:R:N187	14.8703	6.81	Yes	Yes	2	8	9
33	N:N:C96	N:N:L4	13.1576	3.17	Yes	No	0	0	0
34	N:N:L4	N:N:Y27	13.7015	3.52	No	Yes	0	0	0
35	R:R:I158	R:R:L184	56.4093	2.85	Yes	No	0	7	8
36	R:R:L184	R:R:L207	58.3385	2.77	No	Yes	0	8	7
37	R:R:N187	R:R:N210	28.8864	4.09	Yes	No	2	9	9
38	R:R:L207	R:R:V233	46.6432	2.98	Yes	Yes	0	7	7
39	R:R:T257	R:R:V233	16.7002	3.17	Yes	Yes	0	8	7
40	R:R:L207	R:R:L213	15.4849	2.77	Yes	Yes	0	7	9
41	R:R:L213	R:R:N210	30.0125	2.75	Yes	No	0	9	9
42	R:R:L213	R:R:V238	47.0056	2.98	Yes	Yes	0	9	7
43	R:R:V233	R:R:V238	16.4885	3.21	Yes	Yes	0	7	7
44	R:R:L241	R:R:V233	16.4782	2.98	Yes	Yes	0	9	7
45	R:R:L260	R:R:V238	64.9037	2.98	Yes	Yes	0	9	7
46	R:R:L241	R:R:L260	18.5829	5.54	Yes	Yes	0	9	9
47	R:R:L260	R:R:T257	16.6536	2.95	Yes	Yes	0	9	8
48	R:R:L260	R:R:L263	100	4.15	Yes	No	0	9	8
49	R:R:H282	R:R:L263	99.4016	2.57	No	No	0	9	8
50	R:R:H282	R:R:I281	98.6959	3.98	No	Yes	0	9	9
51	R:R:A485	R:R:I281	98.0908	6.5	No	Yes	0	9	9
52	R:R:A485	R:R:Y481	97.9829	6.67	No	Yes	0	9	8
53	R:R:S567	R:R:Y481	40.8239	6.36	No	Yes	5	9	8
54	R:R:K660	R:R:S567	40.7929	3.06	No	No	0	9	9
55	R:R:I568	R:R:K660	39.4241	2.91	Yes	No	0	9	9
56	R:R:W488	R:R:Y481	50.1914	5.79	Yes	Yes	5	9	8
57	R:R:C569	R:R:W488	49.4621	5.22	Yes	Yes	5	9	9
58	R:R:C569	R:R:I470	24.6854	3.27	Yes	No	0	9	8
59	R:R:I470	R:R:Y466	24.6784	10.88	No	Yes	0	8	9
60	R:R:A497	R:R:C569	24.6813	3.61	No	Yes	0	9	9
61	R:R:A497	R:R:Y466	24.5607	2.67	No	Yes	0	9	9
62	R:R:T501	R:R:Y466	47.7154	19.97	Yes	Yes	3	9	9
63	R:R:M463	R:R:T501	70.3149	3.01	Yes	Yes	3	9	9
64	R:R:M463	R:R:S671	69.8972	6.13	Yes	No	0	9	9
65	R:R:D460	R:R:S671	69.1264	7.36	Yes	No	0	9	9
66	R:R:D460	R:R:N432	12.2038	4.04	Yes	No	0	9	9
67	R:R:A457	R:R:N432	11.4128	3.13	No	No	0	9	9
68	R:R:A457	R:R:L436	11.0176	3.15	No	No	0	9	5
69	R:R:C454	R:R:L436	10.6224	3.17	No	No	0	8	5
70	R:R:I568	R:R:L570	38.8079	5.71	Yes	Yes	3	9	9
71	R:R:L570	R:R:T501	23.7589	2.95	Yes	Yes	3	9	9
72	R:R:D460	R:R:L456	36.3353	5.43	Yes	Yes	4	9	9
73	R:R:I515	R:R:L456	16.444	5.71	No	Yes	0	9	9
74	R:R:I515	R:R:L452	16.0533	5.71	No	Yes	0	9	9
75	R:R:L570	W:W:?1	14.9237	12.43	Yes	Yes	3	9	0
76	R:R:D460	R:R:N674	19.9796	8.08	Yes	Yes	4	9	9
77	R:R:Y601	R:R:Y678	12.6198	2.98	Yes	Yes	4	9	9
78	N:N:D52	N:N:P53	18.2795	6.44	Yes	No	0	0	0
79	N:N:F29	N:N:P53	17.8681	10.11	Yes	No	0	0	0
80	N:N:F29	N:N:Y27	15.8504	3.09	Yes	Yes	0	0	0
81	N:N:L99	N:N:S108	17.1518	6.01	Yes	Yes	1	0	0
82	L:L:Q100	N:N:N35	10.517	6.6	Yes	Yes	1	0	0
83	N:N:W33	N:N:Y57	29.3846	5.79	Yes	Yes	0	0	0
84	N:N:D52	R:R:R80	12.4343	10.72	Yes	Yes	1	0	4

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:N32	R:R:I85	2.83	1	Yes	Yes	0	6	0	1
L:L:N32	R:R:N110	12.26	1	Yes	No	0	6	0	1
L:L:N33	R:R:R109	6.03	1	Yes	Yes	0	5	0	1
L:L:Y51	R:R:Y185	8.94	1	Yes	Yes	0	7	0	1
L:L:D53	R:R:K209	4.15	0	No	No	0	7	0	1
L:L:D54	R:R:Q235	2.61	0	No	No	0	4	0	1
L:L:Q55	R:R:N208	7.92	0	Yes	Yes	0	5	0	1
L:L:Q55	R:R:K209	10.85	0	Yes	No	0	7	0	1
L:L:Q55	R:R:Q235	5.12	0	Yes	No	0	4	0	1
L:L:L56	R:R:R255	9.72	1	Yes	Yes	0	4	0	1
L:L:S58	R:R:R274	5.27	1	No	Yes	0	3	0	1
L:L:S58	R:R:D276	5.89	1	No	Yes	0	4	0	1
L:L:G59	R:R:R274	3	0	No	Yes	0	3	0	1
L:L:D95	R:R:I85	4.2	1	Yes	Yes	0	6	0	1
L:L:D95	R:R:R109	10.72	1	Yes	Yes	0	5	0	1
L:L:D98	R:R:K58	5.53	1	No	Yes	0	5	0	1
R:R:E34	R:R:R38	5.82	0	No	Yes	4	4	1	1
N:N:T58	R:R:E34	8.47	12	Yes	No	0	4	0	1
N:N:S56	R:R:E35	11.5	0	No	No	0	1	0	1
R:R:D36	R:R:R38	3.57	0	No	Yes	3	4	2	1
R:R:R38	R:R:T56	12.94	0	Yes	No	4	5	1	2
N:N:Y57	R:R:R38	17.49	1	Yes	Yes	0	4	0	1
R:R:K58	R:R:T40	12.01	1	Yes	No	5	8	1	2
R:R:R80	R:R:T56	3.88	1	Yes	No	4	5	1	2
R:R:I60	R:R:K58	5.82	0	No	Yes	4	5	2	1
N:N:Y103	R:R:K58	7.17	1	Yes	Yes	0	5	0	1
R:R:E61	R:R:I60	2.73	0	No	No	5	4	2	2
R:R:E61	R:R:I85	5.47	0	No	Yes	5	6	2	1
R:R:R80	R:R:S79	5.27	1	Yes	No	4	7	1	1
R:R:S79	R:R:T104	6.4	1	No	No	7	5	1	1
N:N:D55	R:R:S79	7.36	1	Yes	No	0	7	0	1
R:R:R80	R:R:Y82	12.35	1	Yes	No	4	4	1	1
R:R:H105	R:R:R80	16.93	1	Yes	Yes	7	4	1	1
N:N:D52	R:R:R80	10.72	1	Yes	Yes	0	4	0	1
N:N:T54	R:R:R80	2.59	1	Yes	Yes	0	4	0	1
N:N:D55	R:R:R80	13.1	1	Yes	Yes	0	4	0	1
N:N:Y57	R:R:R80	8.23	1	Yes	Yes	0	4	0	1
R:R:E107	R:R:Y82	8.98	1	Yes	No	6	4	1	1
N:N:Y103	R:R:Y82	11.91	1	Yes	No	0	4	0	1
R:R:I85	R:R:N110	11.33	1	Yes	No	6	6	1	1
R:R:H105	R:R:T104	5.48	1	Yes	No	7	5	1	1
N:N:T54	R:R:T104	3.14	1	Yes	No	0	5	0	1
R:R:F130	R:R:H105	7.92	1	Yes	Yes	6	7	1	1
N:N:D52	R:R:H105	6.3	1	Yes	Yes	0	7	0	1
N:N:T54	R:R:H105	2.74	1	Yes	Yes	0	7	0	1
R:R:E107	R:R:R109	11.63	1	Yes	Yes	6	5	1	1
R:R:E107	R:R:F134	8.16	1	Yes	Yes	6	5	1	2
N:N:Y103	R:R:E107	3.37	1	Yes	Yes	0	6	0	1
R:R:F134	R:R:R109	8.55	1	Yes	Yes	5	5	2	1
N:N:S104	R:R:R109	10.54	1	No	Yes	0	5	0	1
R:R:D151	R:R:K129	6.91	0	No	No	4	5	2	1
N:N:T30	R:R:K129	3	0	No	No	0	5	0	1
N:N:T54	R:R:K129	6.01	1	Yes	No	0	5	0	1
R:R:F130	R:R:G132	3.01	1	Yes	No	6	5	1	2
R:R:F130	R:R:I155	3.77	1	Yes	Yes	6	5	1	1
R:R:E157	R:R:F130	4.66	1	Yes	Yes	8	6	2	1
N:N:P101	R:R:F130	5.78	1	Yes	Yes	0	6	0	1
N:N:G102	R:R:F130	4.52	0	No	Yes	0	6	0	1
R:R:F134	R:R:G132	3.01	1	Yes	No	5	5	2	2
R:R:E157	R:R:G132	3.27	1	Yes	No	8	5	2	2
R:R:E157	R:R:F134	8.16	1	Yes	Yes	8	5	2	2
R:R:F134	R:R:T159	5.19	1	Yes	Yes	5	5	2	2
N:N:R28	R:R:I152	3.76	0	No	No	0	3	0	1
R:R:F153	R:R:I155	5.02	1	Yes	Yes	5	5	1	1
R:R:F153	R:R:T179	6.49	1	Yes	No	5	5	1	2
R:R:F153	R:R:T181	3.89	1	Yes	No	5	7	1	2
N:N:S31	R:R:F153	5.28	0	No	Yes	0	5	0	1
N:N:Y32	R:R:F153	4.13	1	Yes	Yes	0	5	0	1
R:R:I155	R:R:T181	4.56	1	Yes	No	5	7	1	2
N:N:P101	R:R:I155	5.08	1	Yes	Yes	0	5	0	1
R:R:E157	R:R:T159	8.47	1	Yes	Yes	8	5	2	2
R:R:E157	R:R:K183	8.1	1	Yes	Yes	8	6	2	1
R:R:T159	R:R:Y185	6.24	1	Yes	Yes	5	7	2	1
R:R:K183	R:R:Y185	3.58	1	Yes	Yes	6	7	1	1
N:N:E100	R:R:K183	6.75	1	Yes	Yes	0	6	0	1
N:N:W107	R:R:K183	9.28	1	Yes	Yes	0	6	0	1
R:R:Y185	R:R:Y206	5.96	1	Yes	Yes	7	6	1	2
R:R:N208	R:R:Y185	17.44	1	Yes	Yes	5	7	1	1
N:N:W107	R:R:Y185	3.86	1	Yes	Yes	0	7	0	1
R:R:K209	R:R:N186	13.99	0	No	No	7	7	1	2
R:R:N208	R:R:Y206	3.49	1	Yes	Yes	5	6	1	2
R:R:D232	R:R:Y206	5.75	1	Yes	Yes	9	6	2	2
R:R:D232	R:R:N208	16.16	1	Yes	Yes	9	5	2	1
R:R:D232	R:R:S234	5.89	1	Yes	No	9	9	2	2
R:R:D232	R:R:I253	12.59	1	Yes	No	9	4	2	2
R:R:R255	R:R:S234	3.95	1	Yes	No	4	9	1	2
R:R:N256	R:R:Q235	2.64	0	No	No	5	4	1	1
R:R:E251	R:R:R274	4.65	0	No	Yes	5	3	2	1
R:R:D276	R:R:I253	2.8	1	Yes	No	4	4	1	2
R:R:N256	R:R:R255	3.62	0	No	Yes	5	4	1	1
R:R:D276	R:R:R255	5.96	1	Yes	Yes	4	4	1	1
R:R:R255	R:R:T399	2.59	1	Yes	Yes	4	4	1	2
R:R:D276	R:R:R274	13.1	1	Yes	Yes	4	3	1	1
R:R:R274	R:R:V397	9.15	1	Yes	No	3	2	1	2
R:R:R274	R:R:T399	2.59	1	Yes	Yes	3	4	1	2
R:R:D276	R:R:T399	5.78	1	Yes	Yes	4	4	1	2
R:R:D203	R:R:F153	2.39	0	No	Yes	6	5	2	1
L:L:D62	R:R:N256	1.35	0	No	No	0	5	0	1
R:R:H32	R:R:R38	1.13	0	No	Yes	5	4	2	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:M463	R:R:T501	3.01	3	Yes	Yes	9	9	2	2
R:R:M463	R:R:Y667	8.38	3	Yes	Yes	9	9	2	1
R:R:T501	R:R:Y466	19.97	3	Yes	Yes	9	9	2	2
R:R:L570	R:R:Y466	3.52	3	Yes	Yes	9	9	1	2
R:R:L663	R:R:Y466	5.86	3	No	Yes	9	9	2	2
R:R:L570	R:R:T501	2.95	3	Yes	Yes	9	9	1	2
R:R:T501	R:R:Y667	6.24	3	Yes	Yes	9	9	2	1
R:R:E506	R:R:V502	4.28	0	Yes	Yes	8	9	2	2
R:R:V502	R:R:Y563	7.57	3	Yes	Yes	9	9	2	2
R:R:P571	R:R:V502	3.53	3	Yes	Yes	9	9	1	2
R:R:S505	R:R:Y667	6.36	0	No	Yes	9	9	2	1
R:R:E506	R:R:V586	8.56	0	Yes	No	8	7	2	1
R:R:P571	R:R:Y563	6.95	3	Yes	Yes	9	9	1	2
R:R:I568	R:R:V566	3.07	3	Yes	Yes	9	9	2	2
R:R:M572	R:R:V566	9.13	3	No	Yes	9	9	1	2
R:R:V566	R:R:V656	3.21	0	Yes	No	9	7	2	1
R:R:I568	R:R:L570	5.71	3	Yes	Yes	9	9	2	1
R:R:I568	R:R:L663	7.14	3	Yes	No	9	9	2	2
R:R:L570	R:R:M572	4.24	3	Yes	No	9	9	1	1
R:R:L570	R:R:L663	4.15	3	Yes	No	9	9	1	2
R:R:L570	W:W:?1	12.43	3	Yes	Yes	9	0	1	0
R:R:P571	R:R:Y582	2.78	3	Yes	Yes	9	9	1	2
R:R:P571	W:W:?1	15.8	3	Yes	Yes	9	0	1	0
R:R:M572	W:W:?1	14.51	3	No	Yes	9	0	1	0
R:R:L580	R:R:T574	4.42	3	No	No	4	6	2	2
R:R:I648	R:R:T574	4.56	3	Yes	No	6	6	1	2
R:R:I648	R:R:L580	2.85	3	Yes	No	6	4	1	2
R:R:I583	R:R:L587	2.85	3	No	Yes	7	8	1	1
R:R:I583	R:R:I648	4.42	3	No	Yes	7	6	1	1
R:R:I583	W:W:?1	9.16	3	No	Yes	7	0	1	0
R:R:V586	W:W:?1	5.74	0	No	Yes	7	0	1	0
R:R:A644	R:R:L587	4.73	3	No	Yes	9	8	1	1
R:R:L587	R:R:L645	2.77	3	Yes	No	8	7	1	2
R:R:L587	W:W:?1	2.66	3	Yes	Yes	8	0	1	0
R:R:I640	R:R:Y667	4.84	3	No	Yes	9	9	1	1
R:R:I640	W:W:?1	7.33	3	No	Yes	9	0	1	0
R:R:I654	R:R:Y643	16.92	3	Yes	Yes	9	8	1	2
R:R:L662	R:R:Y643	3.52	3	No	Yes	8	8	1	2
R:R:A644	W:W:?1	3.03	3	No	Yes	9	0	1	0
R:R:A647	W:W:?1	6.07	0	No	Yes	9	0	1	0
R:R:I648	W:W:?1	3.66	3	Yes	Yes	6	0	1	0
R:R:P652	W:W:?1	3.16	0	No	Yes	9	0	1	0
R:R:I654	R:R:N658	2.83	3	Yes	Yes	9	8	1	2
R:R:I654	R:R:L662	2.85	3	Yes	No	9	8	1	1
R:R:I654	W:W:?1	2.75	3	Yes	Yes	9	0	1	0
R:R:V656	W:W:?1	5.74	0	No	Yes	7	0	1	0
R:R:S659	W:W:?1	9.63	0	No	Yes	9	0	1	0
R:R:L662	W:W:?1	4.44	3	No	Yes	8	0	1	0
R:R:P668	R:R:Y667	4.17	0	No	Yes	9	9	2	1
R:R:Y667	W:W:?1	3.01	3	Yes	Yes	9	0	1	0
R:R:K651	R:R:P652	1.67	0	No	No	4	9	2	1
R:R:I648	R:R:V584	1.54	3	Yes	No	6	5	1	2
R:R:I648	R:R:L649	1.43	3	Yes	No	6	5	1	2

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	7XW6_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	2.57
Number of Linked Nodes	753
Number of Links	1037
Number of Hubs	221
Number of Links mediated by Hubs	737
Number of Communities	18
Number of Nodes involved in Communities	295
Number of Links involved in Communities	483

Path Summary
Number Of Nodes in MetaPath	85
Number Of Links MetaPath	84
Number of Shortest Paths	4366514
Length Of Smallest Path	3
Average Path Length	38.0737
Length of Longest Path	61
Minimum Path Strength	1.17
Average Path Strength	5.73404
Maximum Path Strength	20.995
Minimum Path Correlation	0.7
Average Path Correlation	0.990551
Maximum Path Correlation	1
Minimum % Of Corr. Nodes	2.43902
Average % Of Corr. Nodes	41.9964
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	60.578
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function	• binding • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • D1 dopamine receptor binding • protein binding • signaling receptor binding • G protein-coupled receptor binding • dopamine receptor binding • protein-containing complex binding • G-protein beta/gamma-subunit complex binding • pyrophosphatase activity • GTPase activity • G protein activity • ribonucleoside triphosphate phosphatase activity • molecular function regulator activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • enzyme regulator activity • cyclase regulator activity • enzyme activator activity • cyclase activator activity • molecular function activator activity • adenylate cyclase regulator activity • adenylate cyclase activator activity • cation binding • metal ion binding • developmental process • multicellular organismal process • epithelium development • ectodermal placode morphogenesis • epidermis development • molting cycle process • hair cycle • animal organ development • hair follicle placode formation • tissue development • ectodermal placode formation • anatomical structure morphogenesis • skin development • skin epidermis development • hair follicle development
Gene Ontology	Biological Process	• developmental process • multicellular organismal process • epithelium development • ectodermal placode morphogenesis • epidermis development • molting cycle process • hair cycle • animal organ development • hair follicle placode formation • tissue development • ectodermal placode formation • anatomical structure morphogenesis • skin development • skin epidermis development • hair follicle development • molting cycle • anatomical structure development • anatomical structure formation involved in morphogenesis • ectodermal placode development • hair cycle process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of smell • cellular response to stimulus • cellular response to nitrogen compound • response to stimulus • response to endogenous stimulus • response to peptide hormone • cellular response to peptide hormone stimulus • response to oxygen-containing compound • response to nitrogen compound • response to glucagon • cellular response to oxygen-containing compound • cellular response to glucagon stimulus • cellular response to endogenous stimulus • cellular response to chemical stimulus • response to hormone • response to chemical • cellular process • cellular response to hormone stimulus • multicellular organism development • skeletal system development • bone development • system development • regulation of body fluid levels • wound healing • homotypic cell-cell adhesion • cell activation • hemostasis • biological regulation • platelet aggregation • blood coagulation • cell adhesion • cell-cell adhesion • response to stress • coagulation • regulation of biological quality • response to wounding • platelet activation • response to fluid shear stress • vascular endothelial cell response to laminar fluid shear stress • response to laminar fluid shear stress • cellular response to stress • cellular response to laminar fluid shear stress • vascular endothelial cell response to fluid shear stress • cellular response to fluid shear stress • cognition • developmental growth • growth • response to ketone • response to prostaglandin • response to lipid • response to alcohol • cellular response to prostaglandin stimulus • cellular response to prostaglandin E stimulus • cellular response to alcohol • cellular response to lipid • response to prostaglandin E • cellular response to ketone • regulation of biological process • regulation of cellular process • signaling • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cell communication • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • signal transduction • homeostatic process • positive regulation of biological process • adaptive thermogenesis • positive regulation of metabolic process • multicellular organismal-level homeostasis • regulation of cold-induced thermogenesis • cold-induced thermogenesis • temperature homeostasis • positive regulation of cold-induced thermogenesis • positive regulation of multicellular organismal process • metabolic process • regulation of multicellular organismal process • regulation of metabolic process • positive regulation of cellular process • regulation of localization • establishment of protein localization • nitrogen compound transport • regulation of hormone secretion • regulation of protein localization • regulation of peptide secretion • transport • hormone secretion • protein localization to extracellular region • localization • peptide secretion • regulation of secretion by cell • secretion by cell • amide transport • signal release • intracellular protein localization • regulation of peptide hormone secretion • regulation of signaling • regulation of transport • secretion • regulation of hormone levels • regulation of peptide transport • regulation of establishment of protein localization • establishment of protein localization to extracellular region • export from cell • cell-cell signaling • regulation of protein transport • protein secretion • establishment of localization • regulation of protein secretion • regulation of secretion • peptide transport • protein transport • regulation of insulin secretion • peptide hormone secretion • macromolecule localization • hormone transport • regulation of cell communication • insulin secretion • adenylate cyclase-activating adrenergic receptor signaling pathway • adrenergic receptor signaling pathway • cellular localization • establishment of localization in cell • intracellular transport • regulation of defense response • regulation of response to external stimulus • negative regulation of inflammatory response • negative regulation of biological process • inflammatory response to antigenic stimulus • regulation of response to stress • regulation of immune system process • negative regulation of inflammatory response to antigenic stimulus • defense response • immune response • negative regulation of response to stimulus • negative regulation of immune response • regulation of inflammatory response to antigenic stimulus • response to external stimulus • regulation of inflammatory response • regulation of response to stimulus • negative regulation of immune system process • immune system process • negative regulation of response to external stimulus • negative regulation of defense response • regulation of immune response • inflammatory response • positive regulation of adenylate cyclase activity • positive regulation of molecular function • regulation of molecular function • positive regulation of cyclase activity • activation of adenylate cyclase activity • regulation of adenylate cyclase activity • regulation of catalytic activity • positive regulation of catalytic activity • positive regulation of lyase activity • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • cellular response to monoamine stimulus • renal system process • chemical homeostasis • multicellular organismal-level water homeostasis • multicellular organismal-level chemical homeostasis • renal water homeostasis • cellular anatomical structure • membrane • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cell periphery • cytoplasmic side of plasma membrane • GTPase complex
Gene Ontology	Cellular Component	• cellular anatomical structure • membrane • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cell periphery • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • membrane-bounded organelle • extracellular vesicle • extracellular organelle • extracellular region • organelle • extracellular space • vesicle • extracellular membrane-bounded organelle • intracellular anatomical structure • cytoplasm • cytosol • Golgi apparatus subcompartment • Golgi apparatus • organelle subcompartment • trans-Golgi network membrane • intracellular membrane-bounded organelle • endomembrane system • intracellular organelle • trans-Golgi network • organelle membrane • protein binding • binding • enzyme binding • GTPase binding • protein-containing complex binding • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • multicellular organismal process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development • anatomical structure development • sensory system development • system development • cell population proliferation • cellular process • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • signal transduction • cell communication • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • response to oxygen-containing compound • cellular response to oxygen-containing compound • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to chemical stimulus • cellular response to alcohol • response to hormone • response to chemical • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • small GTPase-mediated signal transduction • Ras protein signal transduction • intracellular signal transduction • intracellular signaling cassette • phospholipase C-activating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular response to nitrogen compound • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • response to nitrogen compound • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to monoamine stimulus • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • synaptic signaling • cellular response to acetylcholine • cell-cell signaling • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • non-motile cilium • 9+0 non-motile cilium • cilium • neuron projection • photoreceptor disc membrane • photoreceptor outer segment • plasma membrane bounded cell projection • cell projection • photoreceptor cell cilium • vacuolar membrane • lytic vacuole • vacuole • lytic vacuole membrane • bounding membrane of organelle • lysosomal membrane • lysosome • synapse • cell junction • G-protein beta-subunit binding • fibroblast proliferation • molecular transducer activity • signaling receptor activity • protein-hormone receptor activity • G protein-coupled receptor activity • transmembrane signaling receptor activity • thyroid-stimulating hormone receptor activity • peptide receptor activity • G protein-coupled peptide receptor activity • response to peptide hormone • cellular response to peptide hormone stimulus • cellular response to thyrotropin-releasing hormone • response to thyrotropin-releasing hormone • hormone-mediated signaling pathway • response to glycoprotein • cellular response to glycoprotein • positive regulation of cell population proliferation • regulation of cell population proliferation • positive regulation of biological process • positive regulation of cellular process • homeostatic process • adaptive thermogenesis • positive regulation of metabolic process • multicellular organismal-level homeostasis • regulation of cold-induced thermogenesis • cold-induced thermogenesis • temperature homeostasis • positive regulation of cold-induced thermogenesis • positive regulation of multicellular organismal process • metabolic process • regulation of multicellular organismal process • regulation of metabolic process • cell surface receptor signaling pathway • G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger • thyroid-stimulating hormone signaling pathway • cell surface • basal part of cell • basal plasma membrane • plasma membrane region • basolateral plasma membrane • receptor complex
SCOP2	Domain Identifier	• Transducin (heterotrimeric G protein), gamma chain • L domain-like
SCOP2	Family Identifier	• Transducin (heterotrimeric G protein), gamma chain • L domain-like
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	HOI
PDB Residues	W:W:?1
Environment Details	Open EMBL-EBI Page
Code	HOI
Name	~{N}-[4-[[2-methoxy-5-[(2~{S})-5-oxidanyl-4-oxidanylidene-3-(phenylmethyl)-1,2-dihydroquinazolin-2-yl]phenyl]methoxy]phenyl]ethanamide
Synonyms
Identifier
Formula	C31 H29 N3 O5
Molecular Weight	523.579
SMILES
PubChem	118685720
Formal Charge	0
Total Atoms	68
Total Chiral Atoms	1
Total Bonds	72
Total Aromatic Bonds	24


Code	NAG
PDB Residues	H:H:?1 H:H:?2 H:H:?3 H:H:?4
Environment Details	Open EMBL-EBI Page
Code	NAG
Name	N-Acetylglucosamine
Synonyms	N-Acetylglucosamine
Identifier
Formula	C8 H15 N O6
Molecular Weight	221.208
SMILES
PubChem	24139
Formal Charge	0
Total Atoms	30
Total Chiral Atoms	5
Total Bonds	30
Total Aromatic Bonds	0


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P16473
Sequence	>7XW6_nogp_Chain_R P C E C H Q E E D F R V T C K D I Q R I P S L P P S T Q T L K L I E T H L R T I P S H A F S N L P N I S R I Y V S I D V T L Q Q L E S H S F Y N L S K V T H I E I R N T R N L T Y I D P D A L K E L P L L K F L G I F N T G L K M F P D L T K V Y S T D I F F I L E I T D N P Y M T S I P V N A F Q G L C N E T L T L K L Y N N G F T S V Q G Y A F N G T K L D A V Y L N K N K Y L T V I D K D A F G G V Y S G P S L L D V S Q T S V T A L P S K G L E H L K E L I A R N T W T L K K L P L S L S F L H L T R A D L S Y P I H C C A F K N Q K E D M V C T P K S D E F N P C E D I M G Y K F L R I V V W F V S L L A L L G N V F V L L I L L T S H Y K L N V P R F L M C N L A F A D F C M G M Y L L L I A S V D L Y T H S E Y Y N H A I D W Q T G P G C N T A G F F T V F A S E L S V Y T L T V I T L E R W Y A I T F A M R L D R K I R L R H A C A I M V G G W V C C F L L A L L P L V G I S S Y A K V S I C L P M D T E T P L A L A Y I V F V L T L N I V A F V I V C C C Y V K I Y I T V R N P D K D T K I A K R M A V L I F T D F I C M A P I S F Y A L S A I L N K P L I T V S N S K I L L V L F Y P L N S C A N P F L Y A I F T K A F Q R D V F I L L S K F G Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	7XW6	A	Protein	Glycoprotein Hormone	TSH	Homo sapiens	M22 Fab	ML109	Gs/β1/γ2	2.78	2022-08-17	doi.org/10.1038/s41586-022-05173-3
	7XW6 (No Gprot)	A	Protein	Glycoprotein Hormone	TSH	Homo sapiens	M22 Fab	ML109		2.78	2022-08-17	doi.org/10.1038/s41586-022-05173-3
	7XW5	A	Protein	Glycoprotein Hormone	TSH	Homo sapiens	TSH	ML109	Gs/β1/γ2	2.96	2022-08-24	doi.org/10.1038/s41586-022-05173-3
	7XW5 (No Gprot)	A	Protein	Glycoprotein Hormone	TSH	Homo sapiens	TSH	ML109		2.96	2022-08-24	doi.org/10.1038/s41586-022-05173-3
	7T9N	A	Protein	Glycoprotein Hormone	TSH	Homo sapiens	M22 Fab	DPPC	Gs/β1/γ2	2.9	2022-08-03	doi.org/10.1038/s41586-022-05159-1
	7T9N (No Gprot)	A	Protein	Glycoprotein Hormone	TSH	Homo sapiens	M22 Fab	DPPC		2.9	2022-08-03	doi.org/10.1038/s41586-022-05159-1
	7UTZ	A	Protein	Glycoprotein Hormone	TSH	Homo sapiens	TR1402	DPPC	Gs/β1/γ2	2.4	2022-08-03	doi.org/10.1038/s41586-022-05159-1
	7UTZ (No Gprot)	A	Protein	Glycoprotein Hormone	TSH	Homo sapiens	TR1402	DPPC		2.4	2022-08-03	doi.org/10.1038/s41586-022-05159-1
	7T9M	A	Protein	Glycoprotein Hormone	TSH	Homo sapiens	-	CS-17 Antibody	-	3.1	2022-08-10	doi.org/10.1038/s41586-022-05159-1
	7T9I	A	Protein	Glycoprotein Hormone	TSH	Homo sapiens	TSH	-	Gs/β1/γ2	2.9	2022-08-03	doi.org/10.1038/s41586-022-05159-1
	7T9I (No Gprot)	A	Protein	Glycoprotein Hormone	TSH	Homo sapiens	TSH	-		2.9	2022-08-03	doi.org/10.1038/s41586-022-05159-1
	7XW7	A	Protein	Glycoprotein Hormone	TSH	Homo sapiens	K1-70	-	-	5.5	2022-08-17	doi.org/10.1038/s41586-022-05173-3

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