Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg Int. Strength Num Of Links Community ConSurf
1H:H:?1 14.0643710
2R:R:T62 5.88754227
3R:R:F72 5.4385169
4R:R:L75 3.89406
5R:R:R80 5.475444
6R:R:Y82 8.2275444
7R:R:D86 5.6325228
8R:R:L92 3.9275418
9R:R:H95 9.6125455
10R:R:F97 5.774169
11R:R:Y98 8.2125452
12R:R:H105 10.485447
13R:R:E107 8.47446
14R:R:T111 4.8975405
15R:R:L114 4.275418
16R:R:D118 6.0125455
17R:R:D120 4.7975455
18R:R:L128 3.87833619
19R:R:F130 7.425406
20R:R:L131 3.48408
21R:R:I133 3.4125418
22R:R:F134 9.3545
23R:R:T136 5.446519
24R:R:L138 5.3875418
25R:R:F141 4.91571717
26R:R:P142 5.095419
27R:R:K146 5.645454
28R:R:F154 5.465616
29R:R:L156 4.362507
30R:R:E157 8.1025448
31R:R:I158 4.574517
32R:R:I167 4.818517
33R:R:N170 8.87418
34R:R:F172 6.886518
35R:R:L175 4.992517
36R:R:L180 4.0725417
37R:R:T181 4.2975407
38R:R:L182 5.304506
39R:R:K183 4.234546
40R:R:Y185 5.99447
41R:R:N187 6.836519
42R:R:F189 8.478518
43R:R:V192 3.895417
44R:R:G194 3.65413
45R:R:Y195 6.74333614
46R:R:N198 8.446517
47R:R:L202 4.53833618
48R:R:N208 7.3325445
49R:R:N210 5.4975419
50R:R:L213 2.866519
51R:R:I216 3.94416
52R:R:K218 8.912514
53R:R:D219 11.018513
54R:R:F221 9.9175419
55R:R:P228 3.3775418
56R:R:L231 3.65617
57R:R:V233 3.105407
58R:R:S234 4.3475449
59R:R:V238 3.845417
60R:R:L241 3.466519
61R:R:S243 5.165415
62R:R:K244 5.00667613
63R:R:E247 6.53333614
64R:R:L249 4.29418
65R:R:L252 3.46419
66R:R:I253 6.214544
67R:R:L260 3.905419
68R:R:L263 5.49518
69R:R:L265 7.1525407
70R:R:F269 4.9225417
71R:R:R274 10.225403
72R:R:D276 12.29404
73R:R:L277 3.992509
74R:R:Y279 5.864519
75R:R:H282 6.2775419
76R:R:F286 6.7025408
77R:R:F405 4.524108
78R:R:D410 6.6154119
79R:R:R418 8.083336119
80R:R:W422 5.9025409
81R:R:N432 3.94479
82R:R:M463 4.705409
83R:R:Y466 9.59409
84R:R:D474 8.4254119
85R:R:Y481 5.825608
86R:R:I486 3.63333618
87R:R:W488 7.653336249
88R:R:T490 3.5125418
89R:R:V502 3.59754129
90R:R:E506 3.956128
91R:R:L507 4.145409
92R:R:R519 3.6625409
93R:R:F525 5.895406
94R:R:W546 6.834179
95R:R:Y563 6.8045129
96R:R:S567 3.365409
97R:R:I568 2.78409
98R:R:D573 5.4325188
99R:R:Y613 6.5454256
100R:R:D619 5.314259
101R:R:L629 4.475479
102R:R:I630 5.1175409
103R:R:T632 6.9675479
104R:R:D633 4.79667678
105R:R:Y643 3.745408
106R:R:Y667 5.6825409
107R:R:N674 7.026579
108R:R:F685 5.235239
109W:W:V18 4.075410
110W:W:M20 5.665410
111W:W:C22 4.8075410
112W:W:Y27 7.755410
113W:W:F29 6.34400
114W:W:Y32 13.7175410
115W:W:I33 5.712510
116W:W:I34 3.2225410
117W:W:H35 8.16333610
118W:W:W36 6.78667610
119W:W:K38 6.266510
120W:W:K40 5.426510
121W:W:L45 6.952500
122W:W:W47 6.41286710
123W:W:I48 4.998510
124W:W:Y50 6.94571710
125W:W:N52 10.925410
126W:W:L53 5.22410
127W:W:N59 7.548510
128W:W:N61 5.8125400
129W:W:F64 6.7525410
130W:W:D73 6.20254130
131W:W:T78 7.01754130
132W:W:Y80 7.87254130
133W:W:M81 7.044510
134W:W:L83 3.968510
135W:W:L86 3.7510
136W:W:Y94 7.014510
137W:W:Y95 6.10167610
138W:W:C96 5.27510
139W:W:R98 13.092510
140W:W:E99 9.762510
141W:W:D100 11.2625410
142W:W:Y101 7.015610
143W:W:Y102 6.47333610
144W:W:R104 7.81833610
145W:W:F108 6.73333610
146W:W:W111 7.31143710
147W:W:Y129 4.8325430
148W:W:L131 4.1875400
149W:W:L145 3.395480
150W:W:L148 2.898530
151W:W:K150 4.265630
152W:W:Y152 6.05667660
153W:W:P154 3.678560
154W:W:W161 5.784580
155W:W:H171 6.09530
156W:W:F173 5530
157W:W:L181 3.1025400
158W:W:Y182 5.8525400
159W:W:S187 4.8875430
160W:W:V188 4.465480
161W:W:W195 4.982580
162W:W:N203 6.395140
163W:W:H206 6.58714760
164Z:Z:L2 5.298520
165Z:Z:L4 3.69571720
166Z:Z:Q6 6.825400
167Z:Z:C23 4.4025420
168Z:Z:Y31 5.3575400
169Z:Z:M32 6.2725420
170Z:Z:W34 7.835420
171Z:Z:F35 6.4275410
172Z:Z:Q36 10.465420
173Z:Z:P43 10.1325410
174Z:Z:W46 12.725420
175Z:Z:V57 6.036520
176Z:Z:R60 5.894520
177Z:Z:F61 7.54714720
178Z:Z:Y70 8.49400
179Z:Z:Y85 5.42667620
180Z:Z:Y86 5.674500
181Z:Z:C87 5.526520
182Z:Z:Q88 9.178510
183Z:Z:Q89 7.384520
184Z:Z:Y90 8.47333610
185Z:Z:Y93 7.18410
186Z:Z:L103 5.1975420
187Z:Z:R107 6.1025400
188Z:Z:P112 4.27400
189Z:Z:F117 4.29400
190Z:Z:Q123 5.12430
191Z:Z:F134 4.61333630
192Z:Z:N136 4.09430
193Z:Z:Y139 6.642590
194Z:Z:P140 6.136590
195Z:Z:K146 3.11754190
196Z:Z:W147 5.3285280
197Z:Z:K148 5.51754190
198Z:Z:I149 5.8325290
199Z:Z:Y172 7.414590
200Z:Z:T179 3.7775430
201Z:Z:E184 7.684310
202Z:Z:Y185 7.5645150
203Z:Z:E194 2.84754190
204Z:Z:H197 7.09400
205Z:Z:E212 5.6954270
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
1R:R:S243 R:R:S268 11.22796.52YesNo155
2R:R:F269 R:R:S268 1002.64YesNo175
3R:R:F269 R:R:L249 28.63576.09YesYes178
4R:R:L231 R:R:L249 28.37634.15YesYes178
5R:R:L231 R:R:V205 24.09392.98YesNo077
6R:R:L202 R:R:V205 24.04115.96YesNo087
7R:R:L182 R:R:L202 19.00042.77YesYes068
8R:R:L156 R:R:L182 14.04654.15YesYes076
9R:R:S268 W:W:N59 88.72585.96NoYes150
10R:R:F154 R:R:L128 18.726.09YesYes169
11R:R:F221 R:R:L231 14.69144.87YesYes197
12R:R:F197 R:R:F221 14.439616.08NoYes099
13R:R:F172 R:R:F197 14.38367.5YesNo089
14R:R:I106 R:R:L128 24.44644.28NoYes079
15R:R:F97 R:R:I106 23.62745.02YesNo097
16R:R:F72 R:R:F97 14.55166.43YesYes1699
17R:R:I78 R:R:L75 14.16424.28NoYes076
18R:R:L50 R:R:L75 11.6664.15NoYes056
19R:R:L50 R:R:P51 10.83311.64NoNo055
20R:R:P51 R:R:T54 10.00025.25NoNo057
21R:R:F269 R:R:L265 71.43953.65YesYes077
22R:R:L263 R:R:L265 37.233211.07YesYes087
23R:R:H282 R:R:L263 37.59146.43YesYes198
24R:R:H282 R:R:I486 76.39662.65YesYes198
25R:R:I486 R:R:S281 75.98243.1YesNo089
26R:R:A485 R:R:S281 75.91653.42NoNo099
27R:R:A485 R:R:Y481 75.85092.67NoYes098
28R:R:Q489 R:R:Y481 29.0984.51NoYes098
29R:R:N406 R:R:Q489 29.0139.24NoNo099
30R:R:N406 R:R:P280 59.92534.89NoNo098
31R:R:P280 R:R:P400 59.73863.9NoNo089
32R:R:P400 R:R:T399 59.55185.25NoNo094
33R:R:D276 R:R:T399 59.36513.01YesNo044
34R:R:D276 R:R:I253 43.45272.8YesYes044
35R:R:I253 R:R:L230 13.56874.28YesNo444
36R:R:L230 R:R:Y206 13.38334.69NoNo046
37R:R:K183 R:R:Y206 11.81313.58YesNo066
38R:R:F130 R:R:H105 15.752715.84YesYes067
39R:R:L265 R:R:L277 34.22144.15YesYes079
40R:R:H282 R:R:L277 44.82765.14YesYes099
41R:R:S567 R:R:Y481 43.68453.82YesYes098
42R:R:N406 R:R:S567 31.11232.98NoYes099
43R:R:E157 R:R:F130 14.17225.83YesYes086
44R:R:D232 R:R:I253 14.751216.79NoYes494
45R:R:D232 R:R:N208 14.556917.5NoYes495
46R:R:N208 R:R:Y185 35.40964.65YesYes457
47R:R:E157 R:R:Y185 20.06454.49YesYes487
48R:R:I253 R:R:S234 14.75133.1YesYes449
49R:R:N208 R:R:S234 29.10962.98YesYes459
50R:R:D276 R:R:R255 14.943611.91YesNo044
51R:R:R255 R:R:S234 14.74963.95NoYes049
52R:R:E157 R:R:F134 11.8113.99YesYes485
53R:R:T159 R:R:Y185 14.756911.24NoYes057
54R:R:I85 R:R:N110 12.79462.83NoNo066
55R:R:E61 R:R:I85 10.23585.47NoNo056
56R:R:E93 R:R:P68 12.35381.57NoNo065
57R:R:I568 R:R:S567 14.14023.1YesYes099
58R:R:I568 R:R:Y466 13.23613.63YesYes099
59R:R:T501 R:R:Y466 12.924919.97NoYes099
60R:R:T501 R:R:Y667 12.8213.75NoYes099
61R:R:M463 R:R:Y667 11.255110.78YesYes099
62R:R:M463 R:R:S671 10.41413.07YesNo099
63R:R:D460 R:R:S671 10.30874.42NoNo099
64W:W:F108 W:W:W111 18.28474.01YesYes100
65W:W:G114 W:W:Y95 10.62814.35NoYes000
66W:W:F108 W:W:H35 13.876410.18YesYes100
67W:W:G114 W:W:Q6 10.19224.93NoNo000
68W:W:G49 W:W:W47 10.77157.04NoYes000
69W:W:G49 W:W:I48 10.65683.53NoYes000
70Z:Z:F97 Z:Z:Q88 73.847216.4NoYes000
71W:W:L45 Z:Z:F97 77.52568.53YesNo000
72Z:Z:L95 Z:Z:Q88 69.46972.66NoYes000
73W:W:L45 Z:Z:Y86 90.05964.69YesYes000
74Z:Z:G100 Z:Z:Y86 12.42442.9NoYes000
75Z:Z:G100 Z:Z:Q6 12.26144.93NoYes000
76Z:Z:T84 Z:Z:Y86 86.79849.99NoYes000
77Z:Z:K102 Z:Z:T84 86.67854.5NoNo000
78Z:Z:E104 Z:Z:K102 86.56089.45NoNo000
79Z:Z:E104 Z:Z:Q165 34.532312.74NoNo900
80Z:Z:Q165 Z:Z:S170 34.53074.33NoNo000
81Z:Z:R107 Z:Z:S170 34.51263.95YesNo000
82Z:Z:R107 Z:Z:T171 67.90477.76YesNo000
83Z:Z:N137 Z:Z:T171 66.8245.85NoNo300
84W:W:H171 Z:Z:N137 66.6036.38YesNo300
85W:W:H171 W:W:S187 32.65894.18YesYes300
86W:W:S187 Z:Z:F134 30.67913.96YesYes300
87Z:Z:E104 Z:Z:Y172 51.9138.98NoYes900
88Z:Z:Y139 Z:Z:Y172 36.88322.98YesYes900
89Z:Z:R107 Z:Z:Y139 34.001811.32YesYes000
90W:W:H171 Z:Z:N136 31.1713.83YesYes300
91Z:Z:F134 Z:Z:N136 30.66333.62YesYes300
92Z:Z:F117 Z:Z:F134 29.24144.29YesYes000
93W:W:L131 Z:Z:F117 23.27156.09YesYes000
94W:W:G146 W:W:L131 45.48413.42NoYes000
95Z:Z:F134 Z:Z:V132 24.13345.24YesNo000
96W:W:L131 Z:Z:V132 23.12584.47YesNo000
97W:W:G146 W:W:W161 44.47472.81NoYes000
98W:W:V188 W:W:W161 37.40648.58YesYes800
99W:W:L145 W:W:V188 27.30614.47YesYes800
100W:W:I217 W:W:L145 22.25292.85NoYes800
101W:W:I217 W:W:W195 12.138310.57NoYes800
102Z:Z:F138 Z:Z:Y172 15.26953.09NoYes000
103R:R:L231 R:R:L252 10.71394.15YesYes179
104R:R:L252 R:R:L277 10.71372.77YesYes099
105W:W:N59 W:W:W47 79.49943.39YesYes100
106W:W:W47 Z:Z:L95 67.963814.81YesNo000
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


2D representation of the interactions of this orthosteric/allosteric ligand.


Links and nodes colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
H:H:?1 H:H:?2 39.01 1 Yes No 0 0 1 1
H:H:?1 R:R:N170 12.32 1 Yes Yes 0 8 1 2
H:H:?1 R:R:Q173 10.75 1 Yes No 0 2 1 2
H:H:?1 R:R:Y195 4.21 1 Yes Yes 0 4 1 1
H:H:?1 R:R:N198 24.64 1 Yes Yes 0 7 1 2
H:H:?1 W:W:Y102 3.16 1 Yes Yes 0 0 1 0
H:H:?1 W:W:R104 4.36 1 Yes Yes 0 0 1 0
H:H:?2 W:W:R104 8.72 1 No Yes 0 0 1 0
R:R:N170 R:R:Q173 10.56 1 Yes No 8 2 2 2
R:R:N170 R:R:N198 8.17 1 Yes Yes 8 7 2 2
R:R:N198 R:R:Q173 2.64 1 Yes No 7 2 2 2
R:R:G194 R:R:Y195 2.9 1 Yes Yes 3 4 2 1
R:R:D217 R:R:G194 5.03 1 No Yes 5 3 2 2
R:R:D219 R:R:G194 5.03 1 Yes Yes 3 3 2 2
R:R:D219 R:R:Y195 17.24 1 Yes Yes 3 4 2 1
R:R:G222 R:R:Y195 2.9 1 No Yes 3 4 2 1
R:R:K244 R:R:Y195 5.97 1 Yes Yes 3 4 1 1
R:R:Y195 W:W:G103 7.24 1 Yes No 4 0 1 0
R:R:G223 R:R:N198 3.39 1 No Yes 7 7 1 2
R:R:K201 R:R:Y225 10.75 0 No No 4 4 2 1
R:R:D217 R:R:K218 4.15 1 No Yes 5 4 2 1
R:R:D217 R:R:D219 9.31 1 No Yes 5 3 2 2
R:R:D219 R:R:K218 19.36 1 Yes Yes 3 4 2 1
R:R:K218 W:W:D107 5.53 1 Yes No 4 0 1 0
R:R:K218 Z:Z:Y31 5.97 1 Yes Yes 4 0 1 0
R:R:K218 Z:Z:Y90 9.55 1 Yes Yes 4 0 1 0
R:R:D219 R:R:K244 4.15 1 Yes Yes 3 3 2 1
R:R:G222 R:R:K244 5.23 1 No Yes 3 3 2 1
R:R:G223 W:W:Y101 5.79 1 No Yes 7 0 1 0
R:R:G223 W:W:Y102 2.9 1 No Yes 7 0 1 0
R:R:Y225 W:W:Y54 4.96 0 No No 4 0 1 0
R:R:E247 R:R:S243 2.87 1 Yes Yes 4 5 1 1
R:R:S243 R:R:S268 6.52 1 Yes No 5 5 1 1
R:R:S243 W:W:Y50 3.82 1 Yes Yes 5 0 1 0
R:R:S243 W:W:N59 7.45 1 Yes Yes 5 0 1 0
R:R:K244 W:W:I33 4.36 1 Yes Yes 3 0 1 0
R:R:K244 W:W:E99 6.75 1 Yes Yes 3 0 1 0
R:R:K244 W:W:Y101 3.58 1 Yes Yes 3 0 1 0
R:R:E247 R:R:G245 3.27 1 Yes No 4 9 1 1
R:R:G245 W:W:Y101 2.9 0 No Yes 9 0 1 0
R:R:E247 W:W:Y50 4.49 1 Yes Yes 4 0 1 0
R:R:E247 W:W:N52 11.83 1 Yes Yes 4 0 1 0
R:R:E247 W:W:N55 11.83 1 Yes No 4 0 1 0
R:R:E247 W:W:G57 4.91 1 Yes No 4 0 1 0
R:R:H248 R:R:H271 15.53 0 No No 4 5 1 2
R:R:H248 W:W:N55 10.2 0 No No 4 0 1 0
R:R:L267 R:R:P264 4.93 0 No No 5 9 1 2
R:R:F269 R:R:S268 2.64 1 Yes No 7 5 2 1
R:R:S268 W:W:N59 5.96 1 No Yes 5 0 1 0
R:R:L267 R:R:S266 1.5 0 No No 5 5 1 2
R:R:L267 W:W:T65 1.47 0 No No 5 0 1 0

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

ShowSimilarityNetwork TypeNameLigandDescription
75.00Single7UTZTR14027UTZ-TSH-TR1402-PubChem 644078-Gs/β1/γ2
60.00Single7T9ITSH7T9I-TSH-TSH-Gs/β1/γ2
40.00Single6O3CCholesterol6O3C-SMO-SAG21k-Cholesterol
33.33Single5L7DCholesterol5L7D-SMO-Cholesterol
33.33Single6D32Cyclopamine6D32-SMO-Cyclopamine-Cyclopamine
33.33Single6D35Cholesterol6D35-SMO-Cholesterol
33.33Single6N51Quisqualate6N51-mGlu5; mGlu5-Quisqualate
33.33Single6N51Quisqualate6N51-mGlu5; mGlu5-Quisqualate
33.33Single6UO8SKF975416UO8-GABAB1, GABAB2-SKF97541-GS39783
33.33Single6UO9SKF975416UO9-GABAB1, GABAB2-SKF97541
33.33Single6W2XPubChem 53110426W2X-GABAB1, GABAB2-PubChem 5311042-PubChem 23727970
33.33Single6W2YPubChem 53110426W2Y-GABAB1; GABAB1-PubChem 5311042-PubChem 23727970
33.33Single6W2YPubChem 53110426W2Y-GABAB1; GABAB1-PubChem 5311042-PubChem 23727970
33.33Single7C7QBaclofen7C7Q-GABAB1, GABAB2-Baclofen-PubChem 7023848
33.33Single7C7SCGP546267C7S-GABAB1, GABAB2-CGP54626
33.33Single7CUMCGP546267CUM-GABAB1, GABAB2-CGP54626-Phospholipid
33.33Single7DD5Ca7DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
33.33Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
33.33Single7DD5Ca7DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
33.33Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
33.33Single7DGEQuisqualate7DGE-mGlu1; mGlu1-Quisqualate
33.33Single7DTTCa7DTT-CaS-Ca-Ca
33.33Single7DTTCa7DTT-CaS-Ca-Ca
33.33Single7DTUTryptophan7DTU-CaS-Tryptophan
33.33Single7DTUTryptophan7DTU-CaS-Tryptophan
33.33Single7DTVCa7DTV-CaS-Ca-Ca; Tryptophan
33.33Single7DTVCa; Tryptophan7DTV-CaS-Ca-Ca; Tryptophan
33.33Single7DTVCa7DTV-CaS-Ca-Ca; Tryptophan
33.33Single7DTVCa; Tryptophan7DTV-CaS-Ca-Ca; Tryptophan
33.33Single7E6TCa7E6T-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
33.33Single7E6TCa; Ca; Cyclomethyltryptophan; PO47E6T-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
33.33Single7E6TCa7E6T-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
33.33Single7E6TCa; Ca; Cyclomethyltryptophan; PO47E6T-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
33.33Single7E9GEglumetad7E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/β1/γ2
33.33Single7E9GEglumetad7E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/β1/γ2
33.33Single7E9HPhosphoserine7E9H-mGlu4; mGlu4-Phosphoserine-Gi3/β1/γ2
33.33Single7E9HPhosphoserine7E9H-mGlu4; mGlu4-Phosphoserine-Gi3/β1/γ2
33.33Single7EB2Baclofen7EB2-GABAB2; GABAB1-Baclofen-rac-BHFF-Gi1/β1/γ2
33.33Single7EPBEglumetad7EPB-mGlu2; mGlu2-Eglumetad
33.33Single7EPBEglumetad7EPB-mGlu2; mGlu2-Eglumetad
33.33Single7FD8Quisqualate7FD8-mGlu5; mGlu5-Quisqualate
33.33Single7FD8Quisqualate7FD8-mGlu5; mGlu5-Quisqualate
33.33Single7FD9LY3414957FD9-mGlu5; mGlu5-LY341495
33.33Single7FD9LY3414957FD9-mGlu5; mGlu5-LY341495
33.33Single7FIHhCG7FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/β1/γ2
33.33Single7FIIhCG7FII-LH-hCG-chim(NtGi1-Gs)/β1/γ2
33.33Single7M3ECa; Ca; Tryptophan; NPS-21437M3E-CaS-Ca; Ca; Tryptophan; NPS-2143
33.33Single7M3ECa; Ca; Tryptophan; NPS-21437M3E-CaS-Ca; Ca; Tryptophan; NPS-2143
33.33Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
33.33Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
33.33Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
33.33Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
33.33Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
33.33Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
33.33Single7MTQLY3414957MTQ-mGlu2; mGlu2-LY341495
33.33Single7MTQLY3414957MTQ-mGlu2; mGlu2-LY341495
33.33Single7MTRGlutamate7MTR-mGlu2; mGlu2-Glutamate-ADX55164
33.33Single7MTRGlutamate7MTR-mGlu2; mGlu2-Glutamate-ADX55164
33.33Single7MTSGlutamate7MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/β1/γ2
33.33Single7MTSGlutamate7MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/β1/γ2
33.33Single7SILCa7SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
33.33Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
33.33Single7SILCa7SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
33.33Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
33.33Single7SIMCa7SIM-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
33.33Single7SIMCa; Ca; Cyclomethyltryptophan; PO47SIM-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
33.33Single7SIMCa7SIM-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
33.33Single7SIMCa; Ca; Cyclomethyltryptophan; PO47SIM-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
33.33Single7T9NM22 Fab7T9N-TSH-M22 Fab-PubChem 644078-Gs/β1/γ2
33.33Single7WI6LY3414957WI6-mGlu3; mGlu3-LY341495
33.33Single7WI6LY3414957WI6-mGlu3; mGlu3-LY341495
33.33Single7WI8LY3414957WI8-mGlu3; mGlu3-LY341495
33.33Single7WI8LY3414957WI8-mGlu3; mGlu3-LY341495
33.33Single7WIHLY27941937WIH-mGlu3; mGlu3-LY2794193
33.33Single7WIHLY27941937WIH-mGlu3; mGlu3-LY2794193
33.33Single7XW6M22 Fab7XW6-TSH-M22 Fab-ML109-Gs/β1/γ2
33.33Single7XW7K1-707XW7-TSH-K1-70
33.33Single8I2GGlycoprotein hormones alpha chain8I2G-FSH-Glycoprotein hormones α chain-Compound 716340-Gs/β1/γ2
33.33Single8JCULY3414958JCU-mGlu2; mGlu3-LY341495
33.33Single8JCULY3414958JCU-mGlu2; mGlu3-LY341495
33.33Single8JCVLY3414958JCV-mGlu2; mGlu3-LY341495
33.33Single8JCVLY3414958JCV-mGlu2; mGlu3-LY341495
33.33Single8JCWLY3414958JCW-mGlu2; mGlu3-LY341495
33.33Single8JCWLY3414958JCW-mGlu2; mGlu3-LY341495
33.33Single8JCXLY3414958JCX-mGlu2; mGlu3-LY341495
33.33Single8JCXLY3414958JCX-mGlu2; mGlu3-LY341495
33.33Single8JCYLY3414958JCY-mGlu2; mGlu3-LY341495
33.33Single8JCYLY3414958JCY-mGlu2; mGlu3-LY341495
33.33Single8JCZLY3414958JCZ-mGlu2; mGlu3-LY341495
33.33Single8JCZLY3414958JCZ-mGlu2; mGlu3-LY341495
33.33Single8JD0Glutamate8JD0-mGlu2; mGlu3-Glutamate-NAM563
33.33Single8JD1Glutamate8JD1-mGlu2; mGlu3-Glutamate
33.33Single8JD1Glutamate8JD1-mGlu2; mGlu3-Glutamate
33.33Single8JD2Glutamate8JD2-mGlu2; mGlu3-Glutamate
33.33Single8JD2Glutamate8JD2-mGlu2; mGlu3-Glutamate
33.33Single8JD3Glutamate8JD3-mGlu2; mGlu3-Glutamate-HZR; PEF-Gi1/β1/γ2
33.33Single8JD3Glutamate8JD3-mGlu2; mGlu3-Glutamate-HZR; PEF-Gi1/β1/γ2
33.33Single8JD4Glutamate8JD4-mGlu2; mGlu4-Glutamate
33.33Single8JD4Glutamate8JD4-mGlu2; mGlu4-Glutamate
33.33Single8JD5Glutamate8JD5-mGlu2; mGlu4-Glutamate-BQI; HZE; PEF-Gi1/β1/γ2
33.33Single8JD5Glutamate8JD5-mGlu2; mGlu4-Glutamate-BQI; HZE; PEF-Gi1/β1/γ2
33.33Single8JD6Phosphoserine8JD6-mGlu4; mGlu4-Phosphoserine-N-(3-chlorophenyl)pyridine-2-carboxamide-Gi3/β1/γ2
33.33Single8JD6Phosphoserine8JD6-mGlu4; mGlu4-Phosphoserine-N-(3-chlorophenyl)pyridine-2-carboxamide-Gi3/β1/γ2
33.33Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
33.33Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
33.33Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
33.33Single8SZGCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-chim(NtGi1-Gq)/β1/γ2
33.33Single8SZGCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-chim(NtGi1-Gq)/β1/γ2
33.33Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/β1/γ2
33.33Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/β1/γ2
33.33Single8SZICa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZI-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi3/β1/γ2
33.33Single8SZICa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZI-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi3/β1/γ2
33.33Single8T7HQuisqualate8T7H-mGlu5; mGlu5-Quisqualate
33.33Single8T7HQuisqualate8T7H-mGlu5; mGlu5-Quisqualate
33.33Single8T8MQuisqualate8T8M-mGlu5; mGlu5-Quisqualate
33.33Single8T8MQuisqualate8T8M-mGlu5; mGlu5-Quisqualate
33.33Single8TAOQuisqualate8TAO-mGlu5; mGlu5-Quisqualate-CDPPB
33.33Single8TAOQuisqualate8TAO-mGlu5; mGlu5-Quisqualate-CDPPB
33.33Single8TQBCa; PAM VU60233268TQB-mGlu3; mGlu3-Ca; PAM VU6023326-Ca
33.33Single8TQBCa; PAM VU60233268TQB-mGlu3; mGlu3-Ca; PAM VU6023326-Ca
33.33Single8TR0LY3414958TR0-mGlu3; mGlu3-LY341495
33.33Single8TR0LY3414958TR0-mGlu3; mGlu3-LY341495
33.33Single8TR2Ca; LY3792688TR2-mGlu3; mGlu3-Ca; LY379268-Ca
33.33Single8TR2Ca; LY3792688TR2-mGlu3; mGlu3-Ca; LY379268-Ca
33.33Single8TRCLY3414958TRC-mGlu3; mGlu3-LY341495
33.33Single8TRCLY3414958TRC-mGlu3; mGlu3-LY341495
33.33Single8TRDLY3414958TRD-mGlu3; mGlu3-LY341495
33.33Single8TRDLY3414958TRD-mGlu3; mGlu3-LY341495
33.33Single8WG9(2S)-2-amino-4-phosphonobutanoic acid8WG9-mGlu4; mGlu2-(2S)-2-amino-4-phosphonobutanoic acid
33.33Single8WGBGlutammate8WGB-mGlu4; mGlu2-Glutammate-W9R-Gi3/β1/γ2
33.33Single8WGBGlutammate8WGB-mGlu4; mGlu2-Glutammate-W9R-Gi3/β1/γ2
33.33Single8WGCLY3792688WGC-mGlu4; mGlu2-LY379268
33.33Single8WGDWAG/WA68WGD-mGlu4; mGlu2-WAG/WA6
33.33Single8WGDWAG/WA68WGD-mGlu4; mGlu2-WAG/WA6
33.33Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
33.33Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
33.33Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/β1/γ2
33.33Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/β1/γ2
33.33Single8WVXNorrin8WVX-LGR4-Norrin
33.33Single8WVYNorrin8WVY-LGR4-Norrin
33.33Single8X0BQuisqualate8X0B-mGlu5; mGlu5-Quisqualate-VU0424465
33.33Single8X0BQuisqualate8X0B-mGlu5; mGlu5-Quisqualate-VU0424465
33.33Single8X0CQuisqualate8X0C-mGlu5; mGlu5-Quisqualate-VU0424465
33.33Single8X0CQuisqualate8X0C-mGlu5; mGlu5-Quisqualate-VU0424465
33.33Single8X0DQuisqualate8X0D-mGlu5; mGlu5-Quisqualate-VU0424465
33.33Single8X0DQuisqualate8X0D-mGlu5; mGlu5-Quisqualate-VU0424465
33.33Single8X0EQuisqualate8X0E-mGlu5; mGlu5-Quisqualate
33.33Single8X0EQuisqualate8X0E-mGlu5; mGlu5-Quisqualate
33.33Single8X0FQuisqualate8X0F-mGlu5; mGlu5-Quisqualate-VU0424465
33.33Single8X0FQuisqualate8X0F-mGlu5; mGlu5-Quisqualate-VU0424465
33.33Single8X0GQuisqualate8X0G-mGlu5; mGlu5-Quisqualate
33.33Single8X0GQuisqualate8X0G-mGlu5; mGlu5-Quisqualate
33.33Single8X0HQuisqualate8X0H-mGlu5; mGlu5-Quisqualate
33.33Single8X0HQuisqualate8X0H-mGlu5; mGlu5-Quisqualate
33.33Single8XUMR-spondin-28XUM-LGR4-R-spondin-2
33.33Single9ASBCa9ASB-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
33.33Single9ASBCa; Ca; Cyclomethyltryptophan; 9IG; PO49ASB-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
33.33Single9AVGCa9AVG-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs)/β1/γ2
33.33Single9AVGCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVG-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs)/β1/γ2
33.33Single9AVLCa9AVL-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi3/β2/γ2
33.33Single9AVLCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVL-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi3/β2/γ2
33.33Single9AVLCa9AVL-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi3/β2/γ2
33.33Single9AVLCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVL-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi3/β2/γ2
33.33Single9AXFCa9AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
33.33Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
33.33Single9AXFCa9AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
33.33Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
33.33Single9AYFCa9AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/β1/γ2
33.33Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/β1/γ2
33.33Single9C1PCa9C1P-CaS-Ca-Ca; Tryptophan; '6218; PO4
33.33Single9C1PCa; Tryptophan; '6218; PO49C1P-CaS-Ca-Ca; Tryptophan; '6218; PO4
33.33Single9C1PCa9C1P-CaS-Ca-Ca; Tryptophan; '6218; PO4
33.33Single9C1PCa; Tryptophan; '6218; PO49C1P-CaS-Ca-Ca; Tryptophan; '6218; PO4
33.33Single9C2FCa9C2F-CaS-Ca-Ca; Ca; Tryptophan; '6218; PO4
33.33Single9C2FCa; Ca; Tryptophan; '6218; PO49C2F-CaS-Ca-Ca; Ca; Tryptophan; '6218; PO4
33.33Single9C2FCa9C2F-CaS-Ca-Ca; Ca; Tryptophan; '6218; PO4
33.33Single9C2FCa; Ca; Tryptophan; '6218; PO49C2F-CaS-Ca-Ca; Ca; Tryptophan; '6218; PO4
33.33Single9II2Glutamate9II2-mGlu3; mGlu3-Glutamate-Arrestin2
33.33Single9II2Glutamate9II2-mGlu3; mGlu3-Glutamate-Arrestin2
33.33Single9II3Glutamate9II3-mGlu3; mGlu3-Glutamate-Arrestin2
33.33Single9II3Glutamate9II3-mGlu3; mGlu3-Glutamate-Arrestin2
25.00Single7DD6Ca7DD6-CaS-Ca-Ca; Ca; Tryptophan
25.00Single7DD6Ca; Ca; Tryptophan7DD6-CaS-Ca-Ca; Ca; Tryptophan
25.00Single7DD6Ca7DD6-CaS-Ca-Ca; Ca; Tryptophan
25.00Single7DD6Ca; Ca; Tryptophan7DD6-CaS-Ca-Ca; Ca; Tryptophan
25.00Single7DD7Ca7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
25.00Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
25.00Single7DD7Ca7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
25.00Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
25.00Single9ASBCa9ASB-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
25.00Single9ASBCa; Ca; Cyclomethyltryptophan; 9IG; PO49ASB-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
25.00Single9AVGCa9AVG-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs)/β1/γ2
25.00Single9AVGCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVG-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs)/β1/γ2
25.00Single9AYFCa9AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/β1/γ2
25.00Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/β1/γ2
20.00Single7KNUCalcitonin gene-related peptide-17KNU-CT Like-Calcitonin gene-related peptide-1-RAMP1
16.67Single7FIGhCG7FIG-LH-hCG-chim(NtGi1L-Gs)/β1/γ2
16.67Single7XW5TSH7XW5-TSH-TSH-ML109-Gs/β1/γ2
16.67Single7ZI0Cholesterol7ZI0-SMO-SAG-Cholesterol
14.29Single8HS2Fab0468HS2-GPR20-Fab046
14.29Single8X9S5alpha-DHT8X9S-ADGRD1-5α-DHT-chim(NtGi1-Gs)/β1/γ2
14.29Single9IV25alpha-DHT9IV2-ADGRD1-5α-DHT-chim(NtGi1-Gs)/β1/γ2
13.64Single4XT3Fractalkine4XT3-US28-Fractalkine
12.50Single6XBM25(S)-Epoxycholesterol6XBM-SMO-25(S)-Epoxycholesterol-Gi1/β1/γ2
12.50Single8U4QREGN7663-Fab8U4Q-CXCR4-REGN7663-Fab-Cholesterol-Gi1/β1/γ2
12.50Consensusp2y_offOrthosteric Ligandp2y1_off
11.76Single7RKFFractalkine7RKF-US28-Fractalkine-GDP-chim(NtGi1-G11)/β1/γ2
11.11Single4XNWMRS25004XNW-P2Y1-MRS2500
11.11Single6D32Cyclopamine6D32-SMO-Cyclopamine-Cyclopamine
11.11Single8JEF(3S)-3-hydroxyoctanoic acid8JEF-HCA3-(3S)-3-hydroxyoctanoic acid-Gi1/β1/γ2
11.11Single8JPSCCL78JPS-ACKR1-CCL7
11.11Single8JRVGlucagon8JRV-Glucagon-Glucagon-Arrestin2
11.11Consensusp2y1_offOrthosteric Ligand4XNW-P2Y1-MRS2500
10.00Single4O9RCyclopamine4O9R-SMO-Cyclopamine
10.00Single6LI0C176LI0-GPR52-C17
10.00Single7VDHC48/807VDH-MRGPRX2-C48/80-Gi1/β1/γ2
10.00Single8HSCFab0468HSC-GPR20-Fab046-Gi1/β1/γ2
10.00Single8U4RREGN7663-Fab8U4R-CXCR4-REGN7663-Fab-Cholesterol
10.00Single9B9Y7DY9B9Y-CB1-7DY
9.09Single3V2WPubChem 518926453V2W-S1P1-PubChem 51892645
9.09Single4BWBNeurotensin4BWB-NTS1-Neurotensin
9.09Single4QINSAG1.54QIN-SMO-SAG1.5
9.09Single5U09Taranabant5U09-CB1-Taranabant
9.09Single6LFOInterleukin-86LFO-CXCR2-Interleukin-8-Gi1/β1/γ2
9.09Single6O3CSAG21k6O3C-SMO-SAG21k-Cholesterol
9.09Single6WWZCCL206WWZ-CCR6-CCL20-Go/β1/γ2
9.09Single7BR3Elagolix7BR3-GnRH1-Elagolix
9.09Single7LCJDanuglipron7LCJ-GLP-1-Danuglipron
9.09Single7VIHCBP-3077VIH-S1P1-CBP-307-Gi1/β1/γ2
9.09Single7VV5C48/807VV5-MRGPRX2-C48/80-Gi1/β1/γ2
9.09Single7WF7S1P7WF7-S1P1-S1P-Gi1/β1/γ2
9.09Single8HMPC178HMP-GPR52-C17-Gs/β1/γ2
9.09Single8U4SREGN7663-Fab8U4S-CXCR4-REGN7663-Fab
9.09Single8U4TREGN7663-Fab8U4T-CXCR4-REGN7663-Fab
9.09Single8XXXCXCL68XXX-CXCR2-CXCL6-Go/β1/γ2
9.09Single9BA0A1AKN9BA0-CB1-A1AKN
9.09Consensusccr6_onOrthosteric Ligand6WWZ-CCR6-CCL20-Go/β1/γ2
9.09Consensusccr6_on_gpOrthosteric Ligand6WWZ-CCR6-CCL20-Go/β1/γ2
9.09Consensuscxcr1_onOrthosteric Ligand8IC0-CXCR1-Interleukin-8-Gi1/β1/γ2
9.09Consensusgnrh1_offOrthosteric Ligand7BR3-GnRH1-Elagolix
9.09Consensusp2y1_onOrthosteric Ligand7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/β1/γ2
9.09Consensuss1p1_offOrthosteric Ligand3V2W-S1P1-PubChem 51892645
8.33Single3V2YPubChem 518926453V2Y-S1P1-PubChem 51892645
8.33Single6XBLSAG6XBL-SMO-SAG-Cholesterol-Gi1/β1/γ2
8.33Single7C2EPubChem 1490507997C2E-GLP-1-PubChem 149050799-Gs/β1/γ2
8.33Single7UTZPubChem 6440787UTZ-TSH-TR1402-PubChem 644078-Gs/β1/γ2
8.33Single7VV6C48/807VV6-MRGPRX2-C48/80
8.33Single7XXH2MeSADP7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/β1/γ2
8.33Single7ZI0SAG7ZI0-SMO-SAG-Cholesterol
8.33Single8H4LDoconexent8H4L-FFA4-Doconexent-chim(NtGi1-Gs-CtGq)/β1/γ2
8.33Consensuscb1_offOrthosteric Ligand5U09-CB1-Taranabant 5TGZ-CB1-AM6538
8.33Consensuscxcr2_onOrthosteric Ligand6LFM-CXCR2-Interleukin-8-Gi1/β1/γ2
8.33Consensusgrh_offOrthosteric Ligandgnrh1_off
8.33Consensusnucleotide_offOrthosteric Ligandadenosine_off p2y_off
8.33Consensusp2y1_on_gpOrthosteric Ligand7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/β1/γ2
7.69Single4QIMANTA XV4QIM-SMO-ANTA XV
7.69Single5T04Neurotensin5T04-NTS1-Neurotensin
7.69Single5TGZAM65385TGZ-CB1-AM6538
7.69Single6D27CAY104716D27-DP2-CAY10471
7.69Single6X1ADanuglipron6X1A-GLP-1-Danuglipron-Gs/β1/γ2
7.69Single6XBM25(S)-Epoxycholesterol6XBM-SMO-25(S)-Epoxycholesterol-Gi1/β1/γ2
7.69Single6Z4VNTS8-136Z4V-NTS1-NTS8-13
7.69Single7FIHOrg435537FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/β1/γ2
7.69Single7LCIDanuglipron7LCI-GLP-1-Danuglipron-Gs/β1/γ2
7.69Single7LCKDanuglipron7LCK-GLP-1-Danuglipron
7.69Single7S15PubChem 1346112237S15-GLP-1-PubChem 134611223
7.69Single7SK8CXCL127SK8-ACKR3-CXCL12-CCX662
7.69Single7VIES1P7VIE-S1P1-S1P-Gi1/β1/γ2
7.69Single7VIFS-FTY720-P7VIF-S1P1-S-FTY720-P-Gi1/β1/γ2
7.69Single7YU4ONO-07405567YU4-LPA1-ONO-0740556
7.69Single7YXAONO-54306087YXA-S1P5-ONO-5430608
7.69Single8IC0Interleukin-88IC0-CXCR1-Interleukin-8-Gi1/β1/γ2
7.69Single9B9ZA1AKO9B9Z-CB1-A1AKO
7.69Single9IVGGLP-1 (Truncated)9IVG-GLP-1-GLP-1 (Truncated)-chim(NtGi1-Gs)/β1/γ2
7.69Consensuscxcr1_on_gpOrthosteric Ligand8IC0-CXCR1-Interleukin-8-Gi1/β1/γ2
7.69Consensuslipid_offOrthosteric Ligandcannabinoid_off paf_off lpl_off prostanoid_off leukotriene_off
7.69Consensusnucleotide_offonOrthosteric Ligandnucleotide_off nucleotide_on
7.69Consensusnucleotide_offon_gpOrthosteric Ligandnucleotide_on_gp nucleotide_off
7.41Single9AUCCalcitonin gene-related peptide-19AUC-CT (AMY1)-Calcitonin gene-related peptide-1-Gs/β1/γ2; RAMP1
7.14Single4JKVTaladegib4JKV-SMO-Taladegib
7.14Single5C1MBU725C1M-μ-BU72
7.14Single6LFMInterleukin-86LFM-CXCR2-Interleukin-8-Gi1/β1/γ2
7.14Single6XBKCholesterol6XBK-SMO-Cholesterol-Gi1/β1/γ2
7.14Single7BB7AVP7BB7-V2-AVP-Gs/β1/γ2
7.14Single7C4SS1P7C4S-S1P3-S1P
7.14Single7EO2FTY720-P7EO2-S1P1-FTY720-P-Gi1/β1/γ2
7.14Single7TD3S1P7TD3-S1P1-S1P-Gi1/β1/γ2
7.14Single7YU3ONO-07405567YU3-LPA1-ONO-0740556-Gi1/β1/γ2
7.14Single7YU6ONO-07405567YU6-LPA1-ONO-0740556-Gi1/β1/γ2
7.14Single8ID4Linoleic acid8ID4-FFA4-Linoleic acid-Gi1/β1/γ2
7.14Single8ZPTPrRP208ZPT-PrRP-PrRP20-chim(NtGi1-Gs-CtGq)/β1/γ2
7.14Consensuscxcr2_on_gpOrthosteric Ligand6LFM-CXCR2-Interleukin-8-Gi1/β1/γ2
7.14Consensuslpa1_onOrthosteric Ligand7TD1-LPA1-LPA-Gi1/β1/γ2 7YU3-LPA1-ONO-0740556-Gi1/β1/γ2
7.14Consensuslpa1_on_gpOrthosteric Ligand7TD1-LPA1-LPA-Gi1/β1/γ2 7YU3-LPA1-ONO-0740556-Gi1/β1/γ2
7.14Consensuss1p5_offOrthosteric Ligand7YXA-S1P5-ONO-5430608
7.14Consensuss1p_offOrthosteric Ligands1p1_off s1p5_off
6.67Single3ZEVNeurotensin3ZEV-NTS1-Neurotensin
6.67Single4BV0Neurotensin4BV0-NTS1-Neurotensin
6.67Single4Z34ONO-97803074Z34-LPA1-ONO-9780307
6.67Single5V56TC1145V56-SMO-TC114
6.67Single5V57TC1145V57-SMO-TC114
6.67Single6OS1TRV0266OS1-AT1-TRV026
6.67Single7EW1Siponimod7EW1-S1P5-Siponimod-Gi1/β1/γ2
6.67Single7EW3S1P7EW3-S1P3-S1P-Gi1/β1/γ2
6.67Single7F1TMIP-1a7F1T-CCR5-MIP-1a
6.67Single7F58THIQ7F58-MC4-THIQ-Gs/β1/γ2
6.67Single7L0PNeurotensin7L0P-NTS1-Neurotensin-Gi1/β1/γ1
6.67Single7L0QNeurotensin7L0Q-NTS1-Neurotensin-Gi1/β1/γ1
6.67Single7R0CAVP7R0C-V2-AVP-Arrestin2
6.67Single7SK7CXCL127SK7-ACKR3-CXCL12-CCX662
6.67Single7T9NPubChem 6440787T9N-TSH-M22 Fab-PubChem 644078-Gs/β1/γ2
6.67Single7TD1LPA7TD1-LPA1-LPA-Gi1/β1/γ2
6.67Single7VIGCBP-3077VIG-S1P1-CBP-307-Gi1/β1/γ2
6.67Single7YU5ONO-07405567YU5-LPA1-ONO-0740556-Gi1/β1/γ2
6.67Single7YU7ONO-07405567YU7-LPA1-ONO-0740556-Gi1/β1/γ2
6.67Single8E0GBU728E0G-μ-BU72
6.67Single8FMZNeurotensin/Neuromedin-N8FMZ-NTS1-Neurotensin/Neuromedin-N-chim(NtGi2L-Gs-CtGq)/β1/γ2
6.67Single8FN1Neurotensin/Neuromedin-N8FN1-NTS1-Neurotensin/Neuromedin-N-chim(NtGi1-Go)/β1/γ2
6.67Single8HQCC5a anaphylatoxin8HQC-C5a1-C5a anaphylatoxin-Go/β1/γ2
6.67Single8I2GCompound 7163408I2G-FSH-Glycoprotein hormones α chain-Compound 716340-Gs/β1/γ2
6.67Single8ID39-Hydroxystearic acid8ID3-FFA4-9-Hydroxystearic acid-Gi1/β1/γ2
6.67Single8ID6Oleic acid8ID6-FFA4-Oleic acid-Gi1/β1/γ2
6.67Single8JBGNeurokinin-B8JBG-NK3-Neurokinin-B-chim(NtGi1-Gs-CtGq)/β1/γ2
6.67Single8JZPC5A anaphylatoxin8JZP-C5a1-C5A anaphylatoxin-Go/β1/γ2
6.67Single8WJXADP8WJX-P2Y1-ADP-chim(Gs-CtGq)/β1/γ2
6.67Single8XX7CXCL58XX7-CXCR2-CXCL5-Go/β1/γ2
6.67Single9ASTLymphotactin9AST-XCR1-Lymphotactin-Gi1/β1/γ2
6.67Single9IZGNKP9IZG-LPA1-NKP-chim(NtGi1-Gs-CtGq)/β1/γ2
6.67Consensusclass-a_offOrthosteric Ligandsensory_off alicarboxylic_off amine_off lipid_off nucleotide_off peptide_off protein_off
6.67Consensusgi_lpaOrthosteric Ligand7TD1-LPA1-LPA-Gi1/β1/γ2 7YU3-LPA1-ONO-0740556-Gi1/β1/γ2
6.67Consensuslpa_onOrthosteric Ligandlpa1_on
6.67Consensuslpa_on_gpOrthosteric Ligandlpa1_on_gp
6.67Consensusmotilin_onOrthosteric Ligand8IBU-Motilin-Erythromycin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
6.67Consensusneurotensin_onOrthosteric Ligandnts1_on
6.67Consensusnts1_onOrthosteric Ligand6OSA-NTS1-JMV449-Gi1/β1/γ2 7L0S-NTS1-Neurotensin-Gi1/β1/γ1
6.67Consensusprotein_offOrthosteric Ligandchemokine_off grh_off
6.67Consensuss1p5_onOrthosteric Ligand7EW1-S1P5-Siponimod-Gi1/β1/γ2
6.67Consensuss1p5_on_gpOrthosteric Ligand7EW1-S1P5-Siponimod-Gi1/β1/γ2
6.25Single4GRVNeurotensin-(8-13)4GRV-NTS1-Neurotensin-(8-13)
6.25Single4XEENeurotensin4XEE-NTS1-Neurotensin
6.25Single4XESNeurotensin4XES-NTS1-Neurotensin
6.25Single6KPGAM8416KPG-CB1-AM841-Gi1/β1/γ2
6.25Single6OS0Angiotensinogen6OS0-AT1-Angiotensinogen
6.25Single6OS2TRV0266OS2-AT1-TRV026
6.25Single6OSAJMV4496OSA-NTS1-JMV449-Gi1/β1/γ2
6.25Single6XOXOrforglipron6XOX-GLP-1-Orforglipron-chim(NtGi1-Gs)/β1/γ2
6.25Single6YVRNTS8-136YVR-NTS1-NTS8-13
6.25Single7EVYSiponimod7EVY-S1P1-Siponimod-Gi1/β1/γ2
6.25Single7EW2Fingolimod7EW2-S1P3-Fingolimod-Gi1/β1/γ2
6.25Single7L0SNeurotensin7L0S-NTS1-Neurotensin-Gi1/β1/γ1
6.25Single7W0NElabela7W0N-Apelin-Elabela-Gi1/β1/γ2
6.25Single7XW5ML1097XW5-TSH-TSH-ML109-Gs/β1/γ2
6.25Single8IBUErythromycin-A8IBU-Motilin-Erythromycin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
6.25Single8JPBNeurotensin-(8-13)8JPB-NTS1-Neurotensin-(8-13)-PubChem 118610427; GDP; Mg-Gq; GRK2
6.25Single8JPCNeurotensin-(8-13)8JPC-NTS1-Neurotensin-(8-13)-PubChem 118610427; GDP; Mg-Gq; GRK2
6.25Single8T3QDocosa-4,7,10,13,16,19-Hexaenoic acid8T3Q-FFA4-Docosa-4,7,10,13,16,19-Hexaenoic acid-chim(NtGi2L-Gs-CtGq)/β1/γ2
6.25Single8U26Protachykinin-18U26-NK1-Protachykinin-1-Gs/β1/γ2
6.25Single8XQJJN2418XQJ-Apelin-JN241
6.25Single8XWACXCL18XWA-CXCR2-CXCL1
6.25Single8XWMCXCL68XWM-CXCR2-CXCL6
6.25Single8XWSCXCL58XWS-CXCR2-CXCL5
6.25Single8XX3CXCL38XX3-CXCR2-CXCL3-Go/β1/γ2
6.25Single9IZHLPA9IZH-LPA1-LPA-chim(NtGi2-G13)/β1/γ2
6.25Consensuscannabinoid_offOrthosteric Ligandcb2_off cb1_off
6.25Consensusccr8_onOrthosteric Ligand8KFX-CCR8-LMD-009-Gi1/β1/γ2 8KFY-CCR8-ZK-756326-Gi1/β1/γ2 8U1U-CCR8-CCL1-Gi1/β1/γ2
6.25Consensuscxcr_onOrthosteric Ligandcxcr3_on cxcr4_on cxcr1_on cxcr2_on
6.25Consensusgi_lipidOrthosteric Ligandgi_cannabinoid gi_ffa gi_leukotriene gi_lpa gi_s1p
6.25Consensusgi_neurotensinOrthosteric Ligand6OSA-NTS1-JMV449-Gi1/β1/γ2 7L0S-NTS1-Neurotensin-Gi1/β1/γ1
6.25Consensuslipid_offonOrthosteric Ligandlipid_off lipid_on
6.25Consensuslipid_offon_gpOrthosteric Ligandlipid_on_gp lipid_off
6.25Consensuslpa1_offOrthosteric Ligand4Z36-LPA1-ONO-3080573 4Z35-LPA1-ONO-9910539 4Z34-LPA1-ONO-9780307
6.25Consensuslpa_offOrthosteric Ligandlpa1_off
6.25Consensuslpl_offOrthosteric Ligands1p_off lpa_off
6.25Consensusmop_onOrthosteric Ligand8F7R-μ-Endomorphin-Gi1/β1/γ2 8EF5-μ-Fentanyl-Gi1/β1/γ2 7SCG-μ-FH210-Gi1/β1/γ2 7T2H-μ-Lofentanil-Gi1/β1/γ2 7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2 8EF6-μ-Morphine-Gi1/β1/γ2 8EFB-μ-Oliceridine-Gi1/β1/γ2 7U2L-μ-PubChem 163201242-Gi1/β1/γ2 8EFO-μ-PZM21-Gi1/β1/γ2 8EFL-μ-SR17018-Gi1/β1/γ2 8F7Q-μ-β-Endorphin-Gi1/β1/γ2 7U2K-μ-C6-guano-Gi1/β1/γ2 8EFQ-μ-Damgo-Gi1/β1/γ2
6.25Consensusmop_on_gpOrthosteric Ligand8F7R-μ-Endomorphin-Gi1/β1/γ2 8EF5-μ-Fentanyl-Gi1/β1/γ2 7SCG-μ-FH210-Gi1/β1/γ2 7T2H-μ-Lofentanil-Gi1/β1/γ2 7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2 8EF6-μ-Morphine-Gi1/β1/γ2 8EFB-μ-Oliceridine-Gi1/β1/γ2 7U2L-μ-PubChem 163201242-Gi1/β1/γ2 8EFO-μ-PZM21-Gi1/β1/γ2 8EFL-μ-SR17018-Gi1/β1/γ2 8F7Q-μ-β-Endorphin-Gi1/β1/γ2 7U2K-μ-C6-guano-Gi1/β1/γ2 8EFQ-μ-Damgo-Gi1/β1/γ2
6.25Consensusmotilin_on_gpOrthosteric Ligand8IBU-Motilin-Erythromycin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
6.25Consensusneurotensin_on_gpOrthosteric Ligandnts1_on_gp
6.25Consensusnts1_on_gpOrthosteric Ligand6OSA-NTS1-JMV449-Gi1/β1/γ2 7L0S-NTS1-Neurotensin-Gi1/β1/γ1
6.25Consensuss1p1_onOrthosteric Ligand7VIE-S1P1-S1P-Gi1/β1/γ2 7VIF-S1P1-S-FTY720-P-Gi1/β1/γ2 7VIG-S1P1-CBP-307-Gi1/β1/γ2 7EVY-S1P1-Siponimod-Gi1/β1/γ2 7EVZ-S1P1-Cenerimod-Gi1/β1/γ2 7EW0-S1P1-Ozanimod-Gi1/β1/γ2 7EW7-S1P1-SEW2871-Gi1/β1/γ2
6.25Consensuss1p1_on_gpOrthosteric Ligand7VIE-S1P1-S1P-Gi1/β1/γ2 7VIF-S1P1-S-FTY720-P-Gi1/β1/γ2 7VIG-S1P1-CBP-307-Gi1/β1/γ2 7EVY-S1P1-Siponimod-Gi1/β1/γ2 7EVZ-S1P1-Cenerimod-Gi1/β1/γ2 7EW0-S1P1-Ozanimod-Gi1/β1/γ2 7EW7-S1P1-SEW2871-Gi1/β1/γ2
6.25Consensuss1p3_onOrthosteric Ligand7EW3-S1P3-S1P-Gi1/β1/γ2 7EW4-S1P3-CYM5541-Gi1/β1/γ2 7EW2-S1P3-Fingolimod-Gi1/β1/γ2
5.88Single4BUONeurotensin4BUO-NTS1-Neurotensin
5.88Single4RWSvMIP-II4RWS-CXCR4-vMIP-II
5.88Single4Z35ONO-99105394Z35-LPA1-ONO-9910539
5.88Single6M1HMaxadilan6M1H-PAC1-Maxadilan-Gs/β1/γ2
5.88Single6UP7Neurotensin6UP7-NTS1-Neurotensin-Arrestin2
5.88Single7EVZCenerimod7EVZ-S1P1-Cenerimod-Gi1/β1/γ2
5.88Single7EW0Ozanimod7EW0-S1P1-Ozanimod-Gi1/β1/γ2
5.88Single7LLLExendin-47LLL-GLP-1-Exendin-4-Gs/β1/γ2
5.88Single7P00Substance-P7P00-NK1-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
5.88Single7VVNPTH7VVN-PTH1-PTH-Gs/β1/γ2
5.88Single7X8RBOC57X8R-GLP-1-BOC5-Gs/β1/γ2
5.88Single7YU8ONO-07405567YU8-LPA1-ONO-0740556-Gi1/β1/γ2
5.88Single8FN0Neurotensin/Neuromedin-N8FN0-NTS1-Neurotensin/Neuromedin-N-PubChem 118610427-chim(NtGi1-Go)/β1/γ2
5.88Single8IYSTUG-8918IYS-FFA4-TUG-891-GDP-chim(NtGi1L-Gq)/β1/γ2
5.88Single8JPFNeurotensin8JPF-NTS1-Neurotensin-PubChem 118610427
5.88Single8K4OCXCL18K4O-KSHV-CXCL1-Gi1/β1/γ1
5.88Single8XVUCXCL28XVU-CXCR2-CXCL2
5.88Single8XWFCXCL38XWF-CXCR2-CXCL3
5.88Single8XWVCXCL18XWV-CXCR2-CXCL1-Go/β1/γ2
5.88Single8XXHCXCL28XXH-CXCR2-CXCL2-Go/β1/γ2
5.88Single8ZX4Lysophosphatidylinositol 8ZX4-GPR55-Lysophosphatidylinositol-chim(NtGi1-G13)/β1/γ2
5.88Single9GE3Lysophosphatidylinositol9GE3-GPR55-Lysophosphatidylinositol-chim(CtGi1-G13)/β1/γ2
5.88Single9IZFNKP9IZF-LPA1-NKP-Gi1/β1/γ2
5.88Consensusclass-a_onOrthosteric Ligandsensory_on alicarboxylic_on amine_on lipid_on nucleotide_on peptide_on protein_on
5.88Consensusgi_s1pOrthosteric Ligand7VIE-S1P1-S1P-Gi1/β1/γ2 7EW3-S1P3-S1P-Gi1/β1/γ2 7EVY-S1P1-Siponimod-Gi1/β1/γ2 7EW1-S1P5-Siponimod-Gi1/β1/γ2 7VIF-S1P1-S-FTY720-P-Gi1/β1/γ2 7VIG-S1P1-CBP-307-Gi1/β1/γ2 7EVZ-S1P1-Cenerimod-Gi1/β1/γ2 7EW4-S1P3-CYM5541-Gi1/β1/γ2 7EW2-S1P3-Fingolimod-Gi1/β1/γ2 7EW0-S1P1-Ozanimod-Gi1/β1/γ2 7EW7-S1P1-SEW2871-Gi1/β1/γ2
5.88Consensusnk1_onOrthosteric Ligand7P00-NK1-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
5.88Consensusnk1_on_gpOrthosteric Ligand7P00-NK1-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
5.56Single5VBLApelin mimetic peptide agonist5VBL-Apelin-Apelin mimetic peptide agonist
5.56Single6KNMJN241-96KNM-Apelin-JN241-9
5.56Single6OS9JMV4496OS9-NTS1-JMV449-Gi1/β1/γ2
5.56Single7AUESetmelanotide7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2
5.56Single7RKNFractalkine7RKN-US28-Fractalkine-Gi1/β1/γ2
5.56Single7RMGSubstance-P7RMG-NK1-Substance-P-chim(Gs-CtGq)/β1/γ2
5.56Single7RMHSubstance-P7RMH-NK1-Substance-P-Gs/β1/γ2
5.56Single7X8SWB4-247X8S-GLP-1-WB4-24-Gs/β1/γ2
5.56Single7XBXCX3CL17XBX-CX3CR1-CX3CL1-Gi1/β1/γ2
5.56Single8H4IDoconexent8H4I-FFA4-Doconexent-chim(NtGi1-Gs)/β1/γ2
5.56Single8JBFSenktide8JBF-NK3-Senktide-chim(NtGi1-Gs-CtGq)/β1/γ2
5.56Single8QJ2pN1628QJ2-MC4-pN162-Gs
5.56Single8XQJJN2418XQJ-Apelin-JN241
5.56Single8XX6CXCL88XX6-CXCR2-CXCL8-Go/β1/γ2
5.56Single9ERXD9-THC analog9ERX-CB1-D9-THC analog-Gi1/β1/γ2
5.56Consensuscxcr3_onOrthosteric Ligand8HNK-CXCR3-CXCL11-Gi1/β1/γ2 8HNL-CXCR3-PS372424-Gi1/β1/γ2
5.56Consensuscxcr4_offOrthosteric Ligand4RWS-CXCR4-vMIP-II 3OE0-CXCR4-CVX15 3OE6-CXCR4-IT1t
5.56Consensuscxcr_on_gpOrthosteric Ligandcxcr3_on_gp cxcr4_on_gp cxcr1_on_gp cxcr2_on_gp
5.56Consensuss1p_onOrthosteric Ligands1p1_on s1p3_on s1p5_on
5.56Consensuss1p_on_gpOrthosteric Ligands1p1_on_gp s1p3_on_gp s1p5_on_gp
5.26Single4XT1Fractalkine4XT1-US28-Fractalkine
5.26Single6X19CHU-1286X19-GLP-1-CHU-128-Gs/β1/γ2
5.26Single7F54Afamelanotide7F54-MC4-Afamelanotide-Gs/β1/γ2
5.26Single7L0RNeurotensin7L0R-NTS1-Neurotensin-Gi1/β1/γ1
5.26Single7RTBPeptide-197RTB-GLP-1-Peptide-19-Gs/β1/γ2
5.26Single7TD4Siponimod7TD4-S1P1-Siponimod-Gi1/β1/γ2
5.26Single7VLACCL15(27-92)7VLA-CCR1-CCL15(27-92)-Gi1/β1/γ2
5.26Single7W0PElabela7W0P-Apelin-Elabela-Gi1/β1/γ2
5.26Single7W2ZGhrelin7W2Z-Ghrelin-Ghrelin-Go/β1/γ2
5.26Single8JIQPeptide-158JIQ-Glucagon-Peptide-15-Gs/β1/γ2
5.26Single8K3ZCXCL128K3Z-CXCR4-CXCL12-Gi1/β1/γ1
5.26Single8U4OCXCL128U4O-CXCR4-CXCL12-Cholesterol-Gi1/β1/γ2
5.26Single8WZ2Orexigenic Neuropeptide QRFP8WZ2-QRFP-Orexigenic Neuropeptide QRFP-chim(NtGi1L-Gs-CtGq)/β1/γ2
5.26Single8XFTR-spondin-28XFT-LGR4-R-spondin-2-ZNRF3
5.26Single8XGMChemerin8XGM-CML2-Chemerin-Gi1/β1/γ2
5.26Single8XWNCXCL88XWN-CXCR2-CXCL8
5.26Single8Y69R-spondin-28Y69-LGR4-R-spondin-2-Cholesterol-ZNRF3
5.26Single9L3YRetinoic acid receptor responder protein 29L3Y-CML2-Retinoic acid receptor responder protein 2-Gi1/β1/γ2
5.26Consensusccr1_onOrthosteric Ligand7VLA-CCR1-CCL15(27-92)-Gi1/β1/γ2
5.26Consensusccr1_on_gpOrthosteric Ligand7VLA-CCR1-CCL15(27-92)-Gi1/β1/γ2
5.26Consensuschemokine_onOrthosteric Ligandccr_on cxcr_on
5.26Consensusclass-a_on_gpOrthosteric Ligandsensory_on_gp alicarboxylic_on_gp amine_on_gp lipid_on_gp nucleotide_on_gp peptide_on_gp protein_on_gp
5.26Consensuscxcr4_onOrthosteric Ligand8K3Z-CXCR4-CXCL12-Gi1/β1/γ1
5.26Consensusgi_opioidOrthosteric Ligand8F7R-μ-Endomorphin-Gi1/β1/γ2 8EF5-μ-Fentanyl-Gi1/β1/γ2 7SCG-μ-FH210-Gi1/β1/γ2 7T2H-μ-Lofentanil-Gi1/β1/γ2 7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2 8DZP-κ-momSalB-Gi1/β1/γ2 8EF6-μ-Morphine-Gi1/β1/γ2 8F7X-NOP-Nociceptin-Gi1/β1/γ2 8EFB-μ-Oliceridine-Gi1/β1/γ2 7U2L-μ-PubChem 163201242-Gi1/β1/γ2 8EFO-μ-PZM21-Gi1/β1/γ2 8EFL-μ-SR17018-Gi1/β1/γ2 8F7Q-μ-β-Endorphin-Gi1/β1/γ2 7U2K-μ-C6-guano-Gi1/β1/γ2 8EFQ-μ-Damgo-Gi1/β1/γ2 8F7S-δ-Deltorphin-Gi1/β1/γ2 8F7W-κ-Dynorphin-Gi1/β1/γ2
5.26Consensuslpl_onOrthosteric Ligands1p_on lpa_on
5.26Consensuslpl_on_gpOrthosteric Ligands1p_on_gp lpa_on_gp
5.26Consensusmc4_onOrthosteric Ligand7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2 7F58-MC4-THIQ-Gs/β1/γ2 7F54-MC4-Afamelanotide-Gs/β1/γ2 7F53-MC4-α-MSH-Gs/β1/γ2 7F55-MC4-Bremelanotide-Gs/β1/γ2
5.26Consensusnk3_onOrthosteric Ligand8JBF-NK3-Senktide-chim(NtGi1-Gs-CtGq)/β1/γ2
5.26Consensusnk3_on_gpOrthosteric Ligand8JBF-NK3-Senktide-chim(NtGi1-Gs-CtGq)/β1/γ2
5.26Consensusp2y_onOrthosteric Ligandp2y1_on p2y10_on p2y12_on
5.00Single6DO1Angiotensin-like peptide S1I86DO1-AT1-Angiotensin-like peptide S1I8
5.00Single6WHCGlu16 analog of GCG6WHC-Glucagon-Glu16 analog of GCG-Gs/β1/γ2
5.00Single7C6A(Sar1,Ile8)-Angiotensin II7C6A-AT2-(Sar1,Ile8)-Angiotensin II
5.00Single7E14Orforglipron7E14-GLP-1-Orforglipron-PubChem 156022738-Gs/β1/γ2
5.00Single7F1QMIP-1a7F1Q-CCR5-MIP-1a-Gi1/β1/γ2
5.00Single7PIVSetmelanotide7PIV-MC4-Setmelanotide-Gs/β1/γ2
5.00Single7RKMFractalkine7RKM-US28-Fractalkine-Gi1/β1/γ2
5.00Single7RMISubstance-P7RMI-NK1-Substance-P-chim(Gs-CtGq)/β1/γ2
5.00Single7SK5CXCL127SK5-ACKR3-CXCL12
5.00Single7TRYUrocortin7TRY-CRF2-Urocortin-chim(NtGi1-G11)/β1/γ2
5.00Single7VBINon-Acylated Tirzepatide7VBI-GLP-1-Non-Acylated Tirzepatide-Gs/β1/γ2
5.00Single8F7QBeta-Endorphin8F7Q-μ-β-Endorphin-Gi1/β1/γ2
5.00Single8IBVMotilin8IBV-Motilin-Motilin-chim(NtGi1-Gs-CtGq)/β1/γ2
5.00Single8IOCGamma-MSH8IOC-MC3-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
5.00Single8JZZC5a-desArg8JZZ-C5a1-C5a-desArg-Go/β1/γ2
5.00Single8Z7JAgonistic antibody8Z7J-Apelin-Agonistic antibody-Gi1/β1/γ2
5.00Consensusccr8_on_gpOrthosteric Ligand8KFX-CCR8-LMD-009-Gi1/β1/γ2 8KFY-CCR8-ZK-756326-Gi1/β1/γ2 8U1U-CCR8-CCL1-Gi1/β1/γ2
5.00Consensuscompl-peptide_onOrthosteric Ligandc5a1_on c3a_on
5.00Consensusmc4_on_gpOrthosteric Ligand7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2 7F58-MC4-THIQ-Gs/β1/γ2 7F54-MC4-Afamelanotide-Gs/β1/γ2 7F53-MC4-α-MSH-Gs/β1/γ2 7F55-MC4-Bremelanotide-Gs/β1/γ2
5.00Consensuss1p3_on_gpOrthosteric Ligand7EW3-S1P3-S1P-Gi1/β1/γ2 7EW4-S1P3-CYM5541-Gi1/β1/γ2 7EW2-S1P3-Fingolimod-Gi1/β1/γ2
5.00Consensustachykinin_on_gpOrthosteric Ligandnk1_on_gp nk2_on_gp nk3_on_gp
4.76Single3OE0CVX153OE0-CXCR4-CVX15
4.76Single6LW5WKYMVm6LW5-FPR2-ALX-WKYMVm
4.76Single6MEOEnvelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd46MEO-CCR5-Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4
4.76Single6UUNAdrenomedullin6UUN-CT Like (AM1)-Adrenomedullin-Gs/β1/γ2; RAMP2
4.76Single7O7F6P4-CCL57O7F-CCR5-6P4-CCL5-Gi1/β1/γ1
4.76Single7RYCOxytocin7RYC-OT-Oxytocin-chim(NtGi2L-Gs-CtGq)/β1/γ2
4.76Single7TD0LPA7TD0-LPA1-LPA-Gi1/β1/γ2
4.76Single7TD2LPA7TD2-LPA1-LPA-Gi1/β1/γ2
4.76Single7XA3CCL27XA3-CCR2-CCL2-Gi1/β1/γ2
4.76Single8K6NPro-neuropeptide-Y8K6N-Y2-Pro-neuropeptide-Y-Gi2/β1/γ1
4.76Single8WKZSBL-MC-318WKZ-MC4-SBL-MC-31
4.76Single8WVUR-spondin-18WVU-LGR4-R-spondin-1-RNF43
4.76Single8XZHMM078XZH-Apelin-MM07-Gi1/β1/γ2
4.76Single8Y69R-spondin-28Y69-LGR4-R-spondin-2-Cholesterol-ZNRF3
4.76Single9IVMGLP-1 (Truncated)9IVM-GLP-1-GLP-1 (Truncated)-LSN3318839-chim(NtGi1-Gs)/β2/γ2
4.76Single9K27PrRP319K27-PrRP-PrRP31-chim(NtGi1-Gq)/β1/γ2
4.76Consensusangiotensin_onOrthosteric Ligandat1_on
4.76Consensusat1_onOrthosteric Ligand7F6G-AT1-SAR1-AngII-Gq/β1/γ2
4.76Consensusc5a1_onOrthosteric Ligand8HK5-C5a1-Complement C5-Gi1/β1/γ2 7Y66-C5a1-BM213-Gi1/β1/γ2 7Y67-C5a1-C089 peptide-Gi1/β1/γ2 7Y64-C5a1-C5a anaphylatoxin-Gi1/β1/γ2
4.76Consensusccr2_onOrthosteric Ligand7XA3-CCR2-CCL2-Gi1/β1/γ2
4.76Consensusccr2_on_gpOrthosteric Ligand7XA3-CCR2-CCL2-Gi1/β1/γ2
4.76Consensusccr_onOrthosteric Ligandccr6_on ccr8_on ccr2_on ccr1_on ccr5_on
4.76Consensuscompl-peptide_on_gpOrthosteric Ligandc5a1_on_gp c3a_on_gp
4.76Consensuscxcr4_on_gpOrthosteric Ligand8K3Z-CXCR4-CXCL12-Gi1/β1/γ1
4.76Consensusmc3_onOrthosteric Ligand8IOC-MC3-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
4.76Consensusmc3_on_gpOrthosteric Ligand8IOC-MC3-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
4.55Single5WB2CX3CL1.355WB2-US28-CX3CL1.35
4.55Single6M1IPACAP6M1I-PAC1-PACAP-Gs/β1/γ2
4.55Single6METEnvelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd46MET-CCR5-Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4
4.55Single6WI9Secretin6WI9-Secretin-Secretin-Gs/β1/γ2
4.55Single7DW9AVP7DW9-V2-AVP-chim(NtGi1-Gs)/β1/γ2
4.55Single7F6GSAR1-AngII7F6G-AT1-SAR1-AngII-Gq/β1/γ2
4.55Single7FIMTirzepatide7FIM-GLP-1-Tirzepatide-Gs/β1/γ2
4.55Single7FINPeptide-20; GGL7FIN-GIP-Peptide-20; GGL-Gs/β1/γ2
4.55Single7TYIAmylin7TYI-CT-Amylin-Gs/β1/γ2
4.55Single7YONPeptide-YY(3-36)7YON-Y2-Peptide-YY(3-36)-Gi1/β1/γ2
4.55Single8H4KGW95088H4K-FFA4-GW9508-chim(NtGi1-Gs-CtGq)/β1/γ2
4.55Single8HA0PTH8HA0-PTH1-PTH-chim(NtGi1-Gs)/β1/γ2
4.55Single8XFPR-spondin-28XFP-LGR4-R-spondin-2-ZNRF3
4.55Single8XZJWN3538XZJ-Apelin-WN353-Gi1/β1/γ2
4.55Single8YW3Retatrutide8YW3-GLP-1-Retatrutide-Gs/β1/γ2
4.55Single8YW4Retatrutide8YW4-GIP-Retatrutide-chim(NtGi1-Gs)/β1/γ22
4.55Single8YW5Retatrutide8YW5-Glucagon-Retatrutide-Gs/β1/γ2
4.55Consensusangiotensin_on_gpOrthosteric Ligandat1_on_gp
4.55Consensusat1_on_gpOrthosteric Ligand7F6G-AT1-SAR1-AngII-Gq/β1/γ2
4.55Consensusc5a1_on_gpOrthosteric Ligand8HK5-C5a1-Complement C5-Gi1/β1/γ2 7Y66-C5a1-BM213-Gi1/β1/γ2 7Y67-C5a1-C089 peptide-Gi1/β1/γ2 7Y64-C5a1-C5a anaphylatoxin-Gi1/β1/γ2
4.55Consensuscxcr3_on_gpOrthosteric Ligand8HNK-CXCR3-CXCL11-Gi1/β1/γ2 8HNL-CXCR3-PS372424-Gi1/β1/γ2
4.55Consensusgi_class-aOrthosteric Ligandgi_peptide gi_sensory gi_alicarboxylic gi_amine gi_lipid gi_nucleotide gi_protein
4.55Consensusgq_angiotensinOrthosteric Ligand7F6G-AT1-SAR1-AngII-Gq/β1/γ2
4.55Consensusgs_vasop-oxyOrthosteric Ligand7DW9-V2-AVP-chim(NtGi1-Gs)/β1/γ2
4.55Consensusp2y_on_gpOrthosteric Ligandp2y1_on_gp p2y10_on_gp p2y12_on_gp
4.55Consensusprotein_offonOrthosteric Ligandprotein_off protein_on
4.55Consensusprotein_offon_gpOrthosteric Ligandprotein_on_gp protein_off
4.55Consensusprotein_onOrthosteric Ligandchemokine_on chemerin_on
4.55Consensustachykinin_onOrthosteric Ligandnk1_on nk2_on nk3_on
4.55Consensusv2_onOrthosteric Ligand7DW9-V2-AVP-chim(NtGi1-Gs)/β1/γ2
4.55Consensusv2_on_gpOrthosteric Ligand7DW9-V2-AVP-chim(NtGi1-Gs)/β1/γ2
4.55Consensusvasop-oxy_onOrthosteric Ligandv2_on
4.55Consensusvasop-oxy_on_gpOrthosteric Ligandv2_on_gp
4.35Single5YQZGlucagon analogue5YQZ-Glucagon-Glucagon analogue
4.35Single6X18GLP-16X18-GLP-1-GLP-1-Gs/β1/γ2
4.35Single7F6HBradykinin7F6H-BK2-Bradykinin-Gq/β1/γ2
4.35Single7F6IKallidin7F6I-BK2-Kallidin-Gq/β1/γ2
4.35Single7F9YGhrelin-287F9Y-Ghrelin-Ghrelin-28-chim(NtGi1-Gs-CtGq)/β1/γ2
4.35Single7LLYOxyntomodulin7LLY-GLP-1-Oxyntomodulin-Gs/β1/γ2
4.35Single7P02Protachykinin-17P02-NK1-Protachykinin-1-chim(NtGi1-Gs)/β1/γ2
4.35Single7TYHCalcitonin-17TYH-CT (AMY2)-Calcitonin-1-Gs/β1/γ2; RAMP2
4.35Single7TYWCalcitonin-17TYW-CT (AMY1)-Calcitonin-1-Gs/β1/γ2; RAMP1
4.35Single7VL9CCL15(26-92)7VL9-CCR1-CCL15(26-92)-Gi1/β1/γ2
4.35Single7WBJPACAP277WBJ-VPAC1-PACAP27-Gs/β1/γ2
4.35Single7X9BNeuropeptide-Y7X9B-Y2-Neuropeptide-Y-Gi1/β1/γ2
4.35Single7Y35Abaloparatide7Y35-PTH1-Abaloparatide-Gs/β1/γ2
4.35Single7Y64C5a anaphylatoxin7Y64-C5a1-C5a anaphylatoxin-Gi1/β1/γ2
4.35Single8E3YPACAP278E3Y-VPAC1-PACAP27-Gs/β1/γ2
4.35Single8E3ZVIP8E3Z-VPAC1-VIP-Gs/β1/γ2
4.35Single8HCQEndothelin-18HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/β1/γ2
4.35Single8HK5Complement C58HK5-C5a1-Complement C5-Gi1/β1/γ2
4.35Single8HNKCXCL118HNK-CXCR3-CXCL11-Gi1/β1/γ2
4.35Single8IA2C5a anaphylatoxin8IA2-C5a1-C5a anaphylatoxin-Go/β1/γ2
4.35Single8XQEApelin-138XQE-Apelin-Apelin-13-Gi1/β1/γ2
4.35Single8XVHEndothelin-18XVH-ETB-Endothelin-1-chim(Gs-CtGq)/β1/γ2
4.35Single8XVIEndothelin-18XVI-ETA-Endothelin-1-chim(Gs-CtGq)/β1/γ2
4.35Single8ZPSPrRP208ZPS-PrRP-PrRP20-chim(NtGi1-Gs-CtGq)/β1/γ2
4.35Consensusccr_on_gpOrthosteric Ligandccr6_on_gp ccr8_on_gp ccr2_on_gp ccr1_on_gp ccr5_on_gp
4.35Consensuschemokine_offOrthosteric Ligandccr_off cxcr_off
4.35Consensuschemokine_on_gpOrthosteric Ligandccr_on_gp cxcr_on_gp
4.35Consensuscxcr_offOrthosteric Ligandcxcr3_off cxcr4_off
4.35Consensuseta_onOrthosteric Ligand8HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/β1/γ2
4.35Consensuseta_on_gpOrthosteric Ligand8HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/β1/γ2
4.35Consensusgi_apelinOrthosteric Ligand8XZH-Apelin-MM07-Gi1/β1/γ2 7W0M-Apelin-PubChem 122701908-Gi1/β1/γ2 8XZJ-Apelin-WN353-Gi1/β1/γ2 8XZF-Apelin-WN561-Gi1/β1/γ2 8XZG-Apelin-Apelin-13-Gi1/β1/γ2
4.35Consensusgi_chemokineOrthosteric Ligand6WWZ-CCR6-CCL20-Go/β1/γ2 8HNK-CXCR3-CXCL11-Gi1/β1/γ2 8K3Z-CXCR4-CXCL12-Gi1/β1/γ1 8IC0-CXCR1-Interleukin-8-Gi1/β1/γ2 6LFM-CXCR2-Interleukin-8-Gi1/β1/γ2 8KFX-CCR8-LMD-009-Gi1/β1/γ2 7F1Q-CCR5-MIP-1a-Gi1/β1/γ2 8HNL-CXCR3-PS372424-Gi1/β1/γ2 8KFY-CCR8-ZK-756326-Gi1/β1/γ2 7O7F-CCR5-6P4-CCL5-Gi1/β1/γ1 8U1U-CCR8-CCL1-Gi1/β1/γ2 7VLA-CCR1-CCL15(27-92)-Gi1/β1/γ2 7XA3-CCR2-CCL2-Gi1/β1/γ2
4.35Consensusopioid_onOrthosteric Ligandmop_on nop_on dop_on kop_on
4.17Single5UIW5P7-CCL55UIW-CCR5-5P7-CCL5
4.17Single6FJ3PTH6FJ3-PTH1-PTH
4.17Single6NBFLong-Acting PTH Analog6NBF-PTH1-Long-Acting PTH Analog-Gs/β1/γ2
4.17Single6NBILong-Acting PTH Analog6NBI-PTH1-Long-Acting PTH Analog-Gs/β1/γ2
4.17Single7KI0Semaglutide7KI0-GLP-1-Semaglutide-Gs/β1/γ2
4.17Single7RA3GIP7RA3-GIP-GIP-chim(NtGi1-Gs)/β1/γ2
4.17Single7RGPTirzepatide7RGP-GLP-1-Tirzepatide-chim(NtGi1-Gs)/β1/γ2
4.17Single7SK3CXCL127SK3-ACKR3-CXCL12
4.17Single7SK4CXCL12_LRHQ7SK4-ACKR3-CXCL12_LRHQ
4.17Single7VABNon-Acylated Tirzepatide7VAB-GIP-Non-Acylated Tirzepatide-chim(NtGi1-Gs)/β1/γ2
4.17Single8E3XPACAP278E3X-PAC1-PACAP27-Gs/β1/γ2
4.17Single8FLRPTHrP(1-36)8FLR-PTH1-PTHrP(1-36)-Gs/β1/γ2
4.17Single8JISPeptide-158JIS-GLP-1-Peptide-15-chim(NtGi1-Gs)/β1/γ2
4.17Single8XQFApelin-138XQF-Apelin-Apelin-13-Gi1/β1/γ2
4.17Single9J1Pg1:Ox9J1P-GLP-1-g1:Ox-chim(NtGi1-Gs)/β1/γ2
4.17Consensusccr5_offOrthosteric Ligand5UIW-CCR5-5P7-CCL5
4.17Consensusccr5_onOrthosteric Ligand7O7F-CCR5-6P4-CCL5-Gi1/β1/γ1 7F1Q-CCR5-MIP-1a-Gi1/β1/γ2
4.17Consensusccr_offOrthosteric Ligandccr2_off ccr5_off
4.17Consensusgi_compl-peptOrthosteric Ligand8HK5-C5a1-Complement C5-Gi1/β1/γ2 8IA8-C3aB-E7 peptide-Gi1/β1/γ2 7Y66-C5a1-BM213-Gi1/β1/γ2 7Y67-C5a1-C089 peptide-Gi1/β1/γ2 8HK2-C3aB-C3a anaphylatoxin-Gi1/β1/γ2 7Y64-C5a1-C5a anaphylatoxin-Gi1/β1/γ2
4.17Consensusgi_peptideOrthosteric Ligandgi_cck gi_apelin gi_compl-pept gi_endothelin gi_formylpeptide gi_galanin gi_ghrelin gi_npy gi_neurotensin gi_opioid gi_orexin gi_relaxin gi_somatostatin
4.17Consensusgi_proteinOrthosteric Ligandgi_chemokine gi_chemerin
4.17Consensusopioid_on_gpOrthosteric Ligandmop_on_gp nop_on_gp dop_on_gp kop_on_gp
4.17Consensusprotein_on_gpOrthosteric Ligandchemokine_on_gp chemerin_on_gp
4.00Single5NX2GLP-1 (Truncated)5NX2-GLP-1-GLP-1 (Truncated)
4.00Single6B3JExendin-P56B3J-GLP-1-Exendin-P5-Gs/β1/γ2
4.00Single6UVAAdrenomedullin-26UVA-CT Like (AM2)-Adrenomedullin-2-Gs/β1/γ2; RAMP3
4.00Single6VCBGLP-16VCB-GLP-1-GLP-1-LSN3160440-Gs/β1/γ2
4.00Single7DTYGIP7DTY-GIP-GIP-Gs/β1/γ2
4.00Single7F53Alpha-MSH7F53-MC4-α-MSH-Gs/β1/γ2
4.00Single7FIYTirzepatide7FIY-GIP-Tirzepatide-Gs/β1/γ2
4.00Single7S1MEx4-D-Ala7S1M-GLP-1-Ex4-D-Ala-Gs/β1/γ2
4.00Single7TYFAmylin7TYF-CT (AMY1)-Amylin-Gs/β1/γ2; RAMP1
4.00Single7TYNCalcitonin-17TYN-CT-Calcitonin-1-Gs/β1/γ2
4.00Single7VQXPACAP277VQX-VPAC1-PACAP27-Gs/β1/γ2
4.00Single7VVKPTH7VVK-PTH1-PTH-Gs/β1/γ2
4.00Single7YOONeuropeptide-Y7YOO-Y2-Neuropeptide-Y-Gi1/β1/γ2
4.00Single8FU6Glucagon derivative ZP37808FU6-Glucagon-Glucagon derivative ZP3780-Gs/β1/γ2
4.00Single8HAOPTH8HAO-PTH1-PTH-chim(NtGi1-Gs)/β1/γ2
4.00Single8XFSR-spondin-28XFS-LGR4-R-spondin-2-ZNRF3
4.00Single8ZH8QRF-Amide8ZH8-QRFP-QRF-Amide-Gq/β1/γ1
4.00Single8ZJGChemerin8ZJG-CML1-Chemerin-Gi1/β1/γ2
4.00Single9K26PrRP319K26-PrRP-PrRP31-Gi1/β1/γ2
4.00Consensusgq_peptideOrthosteric Ligandgq_cck gq_kisspeptin gq_bradykinin gq_bombesin gq_angiotensin
4.00Consensusnpy2_onOrthosteric Ligand7YOO-Y2-Neuropeptide-Y-Gi1/β1/γ2
4.00Consensusnpy2_on_gpOrthosteric Ligand7YOO-Y2-Neuropeptide-Y-Gi1/β1/γ2
4.00Consensuspeptide_onOrthosteric Ligandcck_on angiotensin_on apelin_on bombesin_on bradykinin_on compl-peptide_on endothelin_on formylpeptide_on galanin_on ghrelin_on kisspeptin_on melanocortin_on motilin_on neuromedin-u_on npy_on neurotensin_on opioid_on orexin_on relaxin_on somatostatin_on tachykinin_on trh_on vasop-oxy_on
4.00Consensuspeptide_on_gpOrthosteric Ligandcck_on_gp angiotensin_on_gp apelin_on_gp bombesin_on_gp bradykinin_on_gp compl-peptide_on_gp endothelin_on_gp formylpeptide_on_gp galanin_on_gp ghrelin_on_gp kisspeptin_on_gp melanocortin_on_gp motilin_on_gp neuromedin-u_on_gp npy_on_gp neurotensin_on_gp opioid_on_gp orexin_on_gp relaxin_on_gp somatostatin_on_gp tachykinin_on_gp trh_on_gp vasop-oxy_on_gp
3.85Single5VAIGLP-15VAI-GLP-1-GLP-1-Gs/β1/γ2
3.85Single6LMKGlucagon6LMK-Glucagon-Glucagon-Gs/β1/γ2
3.85Single6LMLGlucagon6LML-Glucagon-Glucagon-Gi1/β1/γ1
3.85Single6NBHLong-Acting PTH Analog6NBH-PTH1-Long-Acting PTH Analog-Gs/β1/γ2
3.85Single6UUSAdrenomedullin6UUS-CT Like (AM2)-Adrenomedullin-Gs/β1/γ2; RAMP3
3.85Single6WZGSecretin6WZG-Secretin-Secretin-Gs/β1/γ2
3.85Single7D68GLP-27D68-GLP-2-GLP-2-Gs/β1/γ2
3.85Single7KI1Taspoglutide7KI1-GLP-1-Taspoglutide-Gs/β1/γ2
3.85Single7TS0Urocortin7TS0-CRF2-Urocortin-chim(NtGi1L-Go)/β1/γ2
3.85Single7TYLAmylin7TYL-CT-Amylin-Gs/β1/γ2
3.85Single7VVJPTHrP(1-36)7VVJ-PTH1-PTHrP(1-36)-Gs/β1/γ2
3.85Single7VVLPTH7VVL-PTH1-PTH-Gs/β1/γ2
3.85Single8F0KPramlintide Analogue San3858F0K-CT (AMY3)-Pramlintide Analogue San385-Gs/β1/γ2; RAMP3
3.85Single8HAFPTHrP(1-36)8HAF-PTH1-PTHrP(1-36)-chim(NtGi1-Gs)/β1/γ2
3.85Single8IY5Endothelin-18IY5-ETB-Endothelin-1-Gi1/β1/γ2
3.85Single8IY6Endothelin-18IY6-ETB-Endothelin-1
3.85Consensusbk2_onOrthosteric Ligand7F6H-BK2-Bradykinin-Gq/β1/γ2 7F6I-BK2-Kallidin-Gq/β1/γ2
3.85Consensusbk2_on_gpOrthosteric Ligand7F6H-BK2-Bradykinin-Gq/β1/γ2 7F6I-BK2-Kallidin-Gq/β1/γ2
3.85Consensusbradykinin_onOrthosteric Ligandbk2_on
3.85Consensusbradykinin_on_gpOrthosteric Ligandbk2_on_gp
3.85Consensusendothelin_onOrthosteric Ligandetb_on eta_on
3.85Consensusgq_bradykininOrthosteric Ligand7F6H-BK2-Bradykinin-Gq/β1/γ2 7F6I-BK2-Kallidin-Gq/β1/γ2
3.85Consensusgs_melanocortinOrthosteric Ligand7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2 7F54-MC4-Afamelanotide-Gs/β1/γ2 7F4D-MC1-α-MSH-chim(NtGi1-Gs)/β1/γ2 8INR-MC5-α-MSH-Ca-chim(NtGi1-Gs)/β1/γ2 7F53-MC4-α-MSH-Gs/β1/γ2 7F55-MC4-Bremelanotide-Gs/β1/γ2 8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1 8IOC-MC3-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2 8IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/β1/γ2 7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2 7F4I-MC1-SHU9119-chim(NtGi1-Gs)/β1/γ2 7F58-MC4-THIQ-Gs/β1/γ2
3.70Single5GLHEndothelin-15GLH-ETB-Endothelin-1
3.70Single6IGKEndothelin-36IGK-ETB-Endothelin-3
3.70Single7DUQGLP-17DUQ-GLP-1-GLP-1-PubChem 156022738-Gs/β1/γ2
3.70Single7RBTTirzepatide7RBT-GIP-Tirzepatide-PubChem 163183774-chim(NtGi1-Gs)/β1/γ2
3.70Single7TYXAmylin7TYX-CT (AMY2)-Amylin-Gs/β1/γ2; RAMP2
3.70Single8U1UCCL18U1U-CCR8-CCL1-Gi1/β1/γ2
3.70Consensusccr5_on_gpOrthosteric Ligand7O7F-CCR5-6P4-CCL5-Gi1/β1/γ1 7F1Q-CCR5-MIP-1a-Gi1/β1/γ2
3.70Consensusgi_npyOrthosteric Ligand8K6M-Y1-Neuropeptide-Y-Gi2/β1/γ1 7X9C-Y4-Pancreatic Hormone-Gi1/β1/γ2 7YOO-Y2-Neuropeptide-Y-Gi1/β1/γ2
3.70Consensusnpy_onOrthosteric Ligandnpy1_on npy2_on npy4_on
3.70Consensusnpy_on_gpOrthosteric Ligandnpy1_on_gp npy2_on_gp npy4_on_gp
3.57Single6LPBPACAP6LPB-PAC1-PACAP-Gs/β1/γ1
3.57Single7SK6CXCL12_LRHQ7SK6-ACKR3-CXCL12_LRHQ
3.57Single7TZFAmylin7TZF-CT (AMY3)-Amylin-Gs/β1/γ2; RAMP3
3.57Single7VBHPeptide-207VBH-GLP-1-Peptide-20-Gs/β1/γ2
3.57Single8F2APramlintide Analogue San3858F2A-CT (AMY3)-Pramlintide Analogue San385-Gs/β1/γ2; RAMP3
3.57Single8FLSAbaloparatide8FLS-PTH1-Abaloparatide-Gs/β1/γ2
3.57Single8FLULong-Acting PTH8FLU-PTH1-Long-Acting PTH-Gs/β1/γ2
3.57Consensusendothelin_on_gpOrthosteric Ligandetb_on_gp eta_on_gp
3.57Consensusmelanocortin_onOrthosteric Ligandmc1_on mc4_on mc2_on mc3_on mc5_on
3.57Consensusmelanocortin_on_gpOrthosteric Ligandmc1_on_gp mc4_on_gp mc2_on_gp mc3_on_gp mc5_on_gp
3.45Single6LRYSarafotoxin-B6LRY-ETB-Sarafotoxin-B
3.45Single6WPWGlucagon derivative ZP37806WPW-Glucagon-Glucagon derivative ZP3780-Gs/β1/γ2
3.45Single7V35Peptide-207V35-Glucagon-Peptide-20-Gs/β1/γ2
3.45Single7VVMPTH7VVM-PTH1-PTH-Gs/β1/γ2
3.45Single8JIPMEDI03828JIP-GLP-1-MEDI0382-chim(NtGi1-Gs)/β1/γ2
3.45Single8JIRSAR4258998JIR-GLP-1-SAR425899-chim(NtGi1-Gs)/β1/γ2
3.45Single9JR2PTH9JR2-PTH1-PTH-chim(NtGi1L-Gs-CtGq)/β1/γ2
3.33Single7TYOCalcitonin7TYO-CT-Calcitonin-Gs/β1/γ2
3.33Single7TYYCalcitonin-17TYY-CT (AMY2)-Calcitonin-1-Gs/β1/γ2; RAMP2
3.33Single7X9ANeuropeptide-Y7X9A-Y1-Neuropeptide-Y-Gi1/β1/γ2
3.33Single7Y36Teriparatide7Y36-PTH1-Teriparatide-Gs/β1/γ2
3.33Single8FLQPTH8FLQ-PTH1-PTH-Gs/β1/γ2
3.33Single8JITMEDI03828JIT-Glucagon-MEDI0382-Gs/β1/γ2
3.33Single8JIUSAR4258998JIU-Glucagon-SAR425899-Gs/β1/γ2
3.33Single9JR3PTH9JR3-PTH1-PTH-chim(NtGi1L-Gs-CtGq)/β1/γ2
3.23Single6E3YCalcitonin gene-related peptide-16E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/β1/γ2; RAMP1
3.12Consensusmc2_onOrthosteric Ligand8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1
3.12Consensusmc2_on_gpOrthosteric Ligand8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1
3.03Single7F16TIP397F16-PTH2-TIP39-Gs/β1/γ2
2.94Single8F0JPramlintide Analogue San458F0J-CT-Pramlintide Analogue San45-Gs/β1/γ2
2.86Single8F2BPramlintide Analogue San458F2B-CT (AMY3)-Pramlintide Analogue San45-Gs/β1/γ2; RAMP3
2.63Single8GY7Corticotropin8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1

PDB Summary
PDB 7T9M
Class A
SubFamily Protein
Type Glycoprotein Hormone
SubType TSH
Species Homo Sapiens
Ligand -
Other Ligand(s) CS-17 Antibody
Protein Partners -
PDB Resolution 3.1
Date 2022-08-10
D.O.I. 10.1038/s41586-022-05159-1
Net Summary
Imin 2.64
Number of Linked Nodes 956
Number of Links 1195
Number of Hubs 205
Number of Links mediated by Hubs 712
Number of Communities 31
Number of Nodes involved in Communities 305
Number of Links involved in Communities 447
Path Summary
Number Of Nodes in MetaPath 107
Number Of Links MetaPath 106
Number of Shortest Paths 4923636
Length Of Smallest Path 3
Average Path Length 33.1329
Length of Longest Path 63
Minimum Path Strength 1.43
Average Path Strength 5.90241
Maximum Path Strength 31.825
Minimum Path Correlation 0.74
Average Path Correlation 0.998093
Maximum Path Correlation 1
Minimum % Of Corr. Nodes 4
Average % Of Corr. Nodes 47.6608
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 54.7493
Maximum Path Hubs % 100

Details about the values in these tables can be found in the corresponding documentation page .
CodeNAG
PDB ResiduesH:H:?1 H:H:?2 H:H:?3 H:H:?4 H:H:?5
Environment DetailsOpen EMBL-EBI Page
CodeNAG
NameN-Acetylglucosamine
SynonymsN-Acetyl-D-glucosamine
Identifier
FormulaC8 H15 N O6
Molecular Weight221.208
SMILES
PubChem24139
Formal Charge0
Total Atoms30
Total Chiral Atoms5
Total Bonds30
Total Aromatic Bonds0



This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
7XW5AProteinGlycoprotein HormoneTSHHomo sapiensTSHML109Gs/β1/γ22.962022-08-2410.1038/s41586-022-05173-3
7XW5 (No Gprot) AProteinGlycoprotein HormoneTSHHomo sapiensTSHML1092.962022-08-2410.1038/s41586-022-05173-3
7XW7AProteinGlycoprotein HormoneTSHHomo sapiensK1-70--5.52022-08-1710.1038/s41586-022-05173-3
7XW6AProteinGlycoprotein HormoneTSHHomo sapiensM22 FabML109Gs/β1/γ22.782022-08-1710.1038/s41586-022-05173-3
7XW6 (No Gprot) AProteinGlycoprotein HormoneTSHHomo sapiensM22 FabML1092.782022-08-1710.1038/s41586-022-05173-3
7T9MAProteinGlycoprotein HormoneTSHHomo sapiens-CS-17 Antibody-3.12022-08-1010.1038/s41586-022-05159-1
7UTZAProteinGlycoprotein HormoneTSHHomo sapiensTR1402PubChem 644078Gs/β1/γ22.42022-08-0310.1038/s41586-022-05159-1
7UTZ (No Gprot) AProteinGlycoprotein HormoneTSHHomo sapiensTR1402PubChem 6440782.42022-08-0310.1038/s41586-022-05159-1
7T9NAProteinGlycoprotein HormoneTSHHomo sapiensM22 FabPubChem 644078Gs/β1/γ22.92022-08-0310.1038/s41586-022-05159-1
7T9N (No Gprot) AProteinGlycoprotein HormoneTSHHomo sapiensM22 FabPubChem 6440782.92022-08-0310.1038/s41586-022-05159-1
7T9IAProteinGlycoprotein HormoneTSHHomo sapiensTSH-Gs/β1/γ22.92022-08-0310.1038/s41586-022-05159-1
7T9I (No Gprot) AProteinGlycoprotein HormoneTSHHomo sapiensTSH-2.92022-08-0310.1038/s41586-022-05159-1




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