Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg Int. Strength Num Of Links Community ConSurf
1W:W:V18 4.075410
2W:W:M20 5.665410
3W:W:C22 4.8075410
4W:W:Y27 7.755410
5W:W:F29 6.34400
6W:W:Y32 13.7175410
7W:W:I33 5.712510
8W:W:I34 3.2225410
9W:W:H35 8.16333610
10W:W:W36 6.78667610
11W:W:K38 6.266510
12W:W:K40 5.426510
13W:W:L45 6.952500
14W:W:W47 6.41286710
15W:W:I48 4.998510
16W:W:Y50 6.94571710
17W:W:N52 10.925410
18W:W:L53 5.22410
19W:W:N59 7.548510
20W:W:N61 5.8125400
21W:W:F64 6.7525410
22W:W:D73 6.20254130
23W:W:T78 7.01754130
24W:W:Y80 7.87254130
25W:W:M81 7.044510
26W:W:L83 3.968510
27W:W:L86 3.7510
28W:W:Y94 7.014510
29W:W:Y95 6.10167610
30W:W:C96 5.27510
31W:W:R98 13.092510
32W:W:E99 9.762510
33W:W:D100 11.2625410
34W:W:Y101 7.015610
35W:W:Y102 6.47610
36W:W:R104 7.805610
37W:W:F108 6.73333610
38W:W:W111 7.31143710
39W:W:Y129 4.8325430
40W:W:L131 4.1875400
41W:W:L145 3.395470
42W:W:L148 2.898530
43W:W:K150 4.265630
44W:W:Y152 6.05667650
45W:W:P154 3.678550
46W:W:W161 5.784570
47W:W:H171 6.09530
48W:W:F173 5530
49W:W:L181 3.1025400
50W:W:Y182 5.8525400
51W:W:S187 4.8875430
52W:W:V188 4.465470
53W:W:W195 4.982570
54W:W:N203 6.395140
55W:W:H206 6.58714750
56X:X:L2 5.298520
57X:X:L4 3.69571720
58X:X:Q6 6.825400
59X:X:C23 4.4025420
60X:X:Y31 5.3575400
61X:X:M32 6.2725420
62X:X:W34 7.835420
63X:X:F35 6.4275410
64X:X:Q36 10.465420
65X:X:P43 10.1325410
66X:X:W46 12.725420
67X:X:V57 6.036520
68X:X:R60 5.894520
69X:X:F61 7.54714720
70X:X:Y70 8.49400
71X:X:Y85 5.42667620
72X:X:Y86 5.674500
73X:X:C87 5.526520
74X:X:Q88 9.178510
75X:X:Q89 7.384520
76X:X:Y90 8.47333610
77X:X:Y93 7.18410
78X:X:L103 5.1975420
79X:X:R107 6.1025400
80X:X:P112 4.27400
81X:X:F117 4.29400
82X:X:Q123 5.12430
83X:X:F134 4.61333630
84X:X:N136 4.09430
85X:X:Y139 6.642590
86X:X:P140 6.136590
87X:X:K146 3.11754160
88X:X:W147 5.3285210
89X:X:K148 5.51754160
90X:X:I149 5.8325220
91X:X:Y172 7.414590
92X:X:T179 3.7775430
93X:X:E184 7.684240
94X:X:Y185 7.5645150
95X:X:E194 2.84754160
96X:X:H197 7.09400
97X:X:E212 5.6954200
98R:R:T62 5.88754257
99R:R:F72 5.4385179
100R:R:L75 3.89406
101R:R:R80 5.475444
102R:R:Y82 8.2275444
103R:R:D86 5.6325258
104R:R:L92 3.9275418
105R:R:H95 9.6125465
106R:R:F97 5.774179
107R:R:Y98 8.2125462
108R:R:H105 10.485447
109R:R:E107 8.47446
110R:R:T111 4.8975405
111R:R:L114 4.275418
112R:R:D118 6.0125465
113R:R:D120 4.7975465
114R:R:L128 3.87833619
115R:R:F130 7.425406
116R:R:L131 3.48408
117R:R:I133 3.4125418
118R:R:F134 9.3545
119R:R:T136 5.446519
120R:R:L138 5.3875418
121R:R:F141 4.91571717
122R:R:P142 5.095419
123R:R:K146 5.645464
124R:R:F154 5.465616
125R:R:L156 4.362507
126R:R:E157 8.1025448
127R:R:I158 4.574517
128R:R:I167 4.818517
129R:R:N170 8.8525418
130R:R:F172 6.886518
131R:R:L175 4.992517
132R:R:L180 4.0725417
133R:R:T181 4.2975407
134R:R:L182 5.304506
135R:R:K183 4.234546
136R:R:Y185 5.99447
137R:R:N187 6.836519
138R:R:F189 8.478518
139R:R:V192 3.895417
140R:R:G194 3.65413
141R:R:Y195 6.73833614
142R:R:N198 8.418517
143R:R:L202 4.53833618
144R:R:N208 7.3325445
145R:R:N210 5.4975419
146R:R:L213 2.866519
147R:R:I216 3.94416
148R:R:K218 8.912514
149R:R:D219 11.018513
150R:R:F221 9.9175419
151R:R:P228 3.3775418
152R:R:L231 3.65617
153R:R:V233 3.105407
154R:R:S234 4.3475449
155R:R:V238 3.845417
156R:R:L241 3.466519
157R:R:S243 5.165415
158R:R:K244 5.00667613
159R:R:E247 6.53333614
160R:R:L249 4.29418
161R:R:L252 3.46419
162R:R:I253 6.214544
163R:R:L260 3.905419
164R:R:L263 5.49518
165R:R:L265 7.1525407
166R:R:F269 4.9225417
167R:R:R274 10.225403
168R:R:D276 12.29404
169R:R:L277 3.992509
170R:R:Y279 5.864519
171R:R:H282 6.2775419
172R:R:F286 6.7025408
173R:R:C398 4.415409
174R:R:F405 4.524108
175R:R:D410 6.6154119
176R:R:R418 8.083336119
177R:R:W422 5.9025409
178R:R:N432 3.94489
179R:R:M463 4.705409
180R:R:Y466 9.59409
181R:R:D474 8.4254119
182R:R:Y481 5.825608
183R:R:I486 3.63333618
184R:R:W488 7.653336299
185R:R:T490 3.5125418
186R:R:V502 3.59754129
187R:R:E506 3.956128
188R:R:L507 4.145409
189R:R:R519 3.6625409
190R:R:F525 5.895406
191R:R:W546 6.834189
192R:R:Y563 6.8045129
193R:R:S567 3.365409
194R:R:I568 2.78409
195R:R:D573 5.4325198
196R:R:Y613 6.5454306
197R:R:D619 5.314309
198R:R:L629 4.475489
199R:R:I630 5.1175409
200R:R:T632 6.9675489
201R:R:D633 4.79667688
202R:R:Y643 3.745408
203R:R:Y667 5.6825409
204R:R:N674 7.026589
205R:R:F685 5.235289
206H:H:?1 13.9486710
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
1W:W:G114 W:W:Q6 10.20734.93NoNo000
2W:W:G49 W:W:I48 10.65843.53NoYes000
3W:W:G49 W:W:W47 10.77317.04NoYes000
4W:W:F108 W:W:H35 13.891410.18YesYes100
5W:W:F108 W:W:W111 18.3074.01YesYes100
6W:W:G114 W:W:Y95 10.64334.35NoYes000
7W:W:L45 X:X:Y86 90.09614.69YesYes000
8R:R:S243 R:R:S268 11.22796.52YesNo155
9X:X:G100 X:X:Q6 12.26914.93NoYes000
10X:X:G100 X:X:Y86 12.43212.9NoYes000
11X:X:L95 X:X:Q88 69.47382.66NoYes000
12X:X:F97 X:X:Q88 73.858516.4NoYes000
13W:W:G146 W:W:L131 45.50723.42NoYes000
14W:W:L131 X:X:F117 23.28336.09YesYes000
15X:X:F117 X:X:F134 29.25624.29YesYes000
16W:W:S187 X:X:F134 30.69453.96YesYes300
17W:W:H171 W:W:S187 32.67534.18YesYes300
18W:W:H171 X:X:N137 66.63646.38YesNo300
19X:X:N137 X:X:T171 66.85765.85NoNo300
20X:X:R107 X:X:T171 67.93897.76YesNo000
21X:X:R107 X:X:Y139 34.018611.32YesYes000
22X:X:Y139 X:X:Y172 36.90132.98YesYes900
23X:X:E104 X:X:Y172 51.93938.98NoYes900
24X:X:E104 X:X:K102 86.60379.45NoNo000
25X:X:K102 X:X:T84 86.72154.5NoNo000
26X:X:T84 X:X:Y86 86.84149.99NoYes000
27W:W:L131 X:X:V132 23.13744.47YesNo000
28X:X:F134 X:X:V132 24.14555.24YesNo000
29X:X:F134 X:X:N136 30.67873.62YesYes300
30W:W:H171 X:X:N136 31.18663.83YesYes300
31X:X:R107 X:X:S170 34.53033.95YesNo000
32X:X:Q165 X:X:S170 34.54734.33NoNo000
33X:X:E104 X:X:Q165 34.548812.74NoNo900
34W:W:L145 W:W:V188 27.324.47YesYes700
35W:W:V188 W:W:W161 37.42548.58YesYes700
36W:W:G146 W:W:W161 44.49732.81NoYes000
37W:W:I217 W:W:W195 12.144510.57NoYes700
38W:W:I217 W:W:L145 22.26432.85NoYes700
39X:X:F138 X:X:Y172 15.27843.09NoYes000
40R:R:L156 R:R:L182 14.06564.15YesYes076
41R:R:L182 R:R:L202 19.02412.77YesYes068
42R:R:L202 R:R:V205 24.06945.96YesNo087
43R:R:L231 R:R:V205 24.12212.98YesNo077
44R:R:L231 R:R:L249 28.41974.15YesYes178
45R:R:F269 R:R:L249 28.67956.09YesYes178
46R:R:F269 R:R:S268 1002.64YesNo175
47R:R:F172 R:R:F197 14.40317.5YesNo089
48R:R:F197 R:R:F221 14.459116.08NoYes099
49R:R:F221 R:R:L231 14.7114.87YesYes197
50R:R:L263 R:R:L265 37.179311.07YesYes087
51R:R:F269 R:R:L265 71.39553.65YesYes077
52R:R:F130 R:R:H105 15.774215.84YesYes067
53R:R:K183 R:R:Y206 11.82923.58YesNo066
54R:R:L230 R:R:Y206 13.40164.69NoNo046
55R:R:I253 R:R:L230 13.58724.28YesNo444
56R:R:D276 R:R:I253 43.5122.8YesYes044
57R:R:D276 R:R:T399 59.44613.01YesNo044
58R:R:P400 R:R:T399 59.63315.25NoNo094
59R:R:P280 R:R:P400 59.82013.9NoNo089
60R:R:N406 R:R:P280 60.00714.89NoNo098
61R:R:N406 R:R:Q489 29.06719.24NoNo099
62R:R:Q489 R:R:Y481 29.15234.51NoYes098
63R:R:A485 R:R:Y481 75.71272.67NoYes098
64R:R:A485 R:R:S281 75.77853.42NoNo099
65R:R:I486 R:R:S281 75.84473.1YesNo089
66R:R:H282 R:R:I486 76.2612.65YesYes198
67R:R:H282 R:R:L263 37.52386.43YesYes198
68R:R:E157 R:R:F130 14.19155.83YesYes086
69R:R:E157 R:R:F134 11.826113.99YesYes485
70R:R:E157 R:R:Y185 20.09184.49YesYes487
71R:R:N208 R:R:Y185 35.4584.65YesYes457
72R:R:D232 R:R:N208 14.576717.5NoYes495
73R:R:D232 R:R:I253 14.771316.79NoYes494
74R:R:T159 R:R:Y185 14.777111.24NoYes057
75R:R:N208 R:R:S234 29.14932.98YesYes459
76R:R:I253 R:R:S234 14.77153.1YesYes449
77R:R:R255 R:R:S234 14.76973.95NoYes049
78R:R:D276 R:R:R255 14.96411.91YesNo044
79R:R:N406 R:R:S567 31.142.98NoYes099
80R:R:S567 R:R:Y481 43.48123.82YesYes098
81R:R:H282 R:R:L277 44.77525.14YesYes099
82R:R:L265 R:R:L277 34.1994.15YesYes079
83R:R:P51 R:R:T54 10.00625.25NoNo057
84R:R:L50 R:R:P51 10.83961.64NoNo055
85R:R:L50 R:R:L75 11.6734.15NoYes056
86R:R:I78 R:R:L75 14.17274.28NoYes076
87R:R:F72 R:R:F97 14.57056.43YesYes1799
88R:R:F97 R:R:I106 23.65185.02YesNo097
89R:R:I106 R:R:L128 24.47124.28NoYes079
90R:R:F154 R:R:L128 18.73796.09YesYes169
91R:R:E61 R:R:I85 10.24985.47NoNo056
92R:R:I85 R:R:N110 12.81212.83NoNo066
93R:R:E93 R:R:P68 12.3831.57NoNo065
94R:R:T501 R:R:Y667 12.83293.75NoYes099
95R:R:T501 R:R:Y466 12.936919.97NoYes099
96R:R:I568 R:R:Y466 13.24843.63YesYes099
97R:R:I568 R:R:S567 14.14783.1YesYes099
98R:R:M463 R:R:Y667 11.265610.78YesYes099
99R:R:D460 R:R:S671 10.31834.42NoNo099
100R:R:M463 R:R:S671 10.42383.07YesNo099
101W:W:W47 X:X:L95 67.965414.81YesNo000
102W:W:N59 W:W:W47 79.49953.39YesYes100
103R:R:S268 W:W:N59 88.72595.96NoYes150
104W:W:L45 X:X:F97 77.54288.53YesNo000
105R:R:L231 R:R:L252 10.71874.15YesYes179
106R:R:L252 R:R:L277 10.72252.77YesYes099
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


2D representation of the interactions of this orthosteric/allosteric ligand.


Links and nodes colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:K244 W:W:I33 4.36 1 Yes Yes 3 0 1 0
R:R:S243 W:W:Y50 3.82 1 Yes Yes 5 0 1 0
R:R:E247 W:W:Y50 4.49 1 Yes Yes 4 0 1 0
R:R:E247 W:W:N52 11.83 1 Yes Yes 4 0 1 0
R:R:Y225 W:W:Y54 4.96 0 No No 4 0 1 0
R:R:E247 W:W:N55 11.83 1 Yes No 4 0 1 0
R:R:H248 W:W:N55 10.2 0 No No 4 0 1 0
R:R:E247 W:W:G57 4.91 1 Yes No 4 0 1 0
R:R:S243 W:W:N59 7.45 1 Yes Yes 5 0 1 0
R:R:S268 W:W:N59 5.96 1 No Yes 5 0 1 0
R:R:K244 W:W:E99 6.75 1 Yes Yes 3 0 1 0
R:R:G223 W:W:Y101 5.79 1 No Yes 7 0 1 0
R:R:K244 W:W:Y101 3.58 1 Yes Yes 3 0 1 0
R:R:G245 W:W:Y101 2.9 0 No Yes 9 0 1 0
R:R:G223 W:W:Y102 2.9 1 No Yes 7 0 1 0
H:H:?1 W:W:Y102 3.14 1 Yes Yes 0 0 1 0
R:R:Y195 W:W:G103 7.24 1 Yes No 4 0 1 0
H:H:?1 W:W:R104 4.33 1 Yes Yes 0 0 1 0
H:H:?2 W:W:R104 8.67 1 No Yes 0 0 1 0
R:R:K218 W:W:D107 5.53 1 Yes No 4 0 1 0
R:R:K218 X:X:Y31 5.97 1 Yes Yes 4 0 1 0
R:R:K218 X:X:Y90 9.55 1 Yes Yes 4 0 1 0
R:R:N170 R:R:Q173 10.56 1 Yes No 8 2 2 2
R:R:N170 R:R:N198 8.17 1 Yes Yes 8 7 2 2
H:H:?1 R:R:N170 12.25 1 Yes Yes 0 8 1 2
R:R:N198 R:R:Q173 2.64 1 Yes No 7 2 2 2
H:H:?1 R:R:Q173 10.69 1 Yes No 0 2 1 2
R:R:G194 R:R:Y195 2.9 1 Yes Yes 3 4 2 1
R:R:D217 R:R:G194 5.03 1 No Yes 5 3 2 2
R:R:D219 R:R:G194 5.03 1 Yes Yes 3 3 2 2
R:R:D219 R:R:Y195 17.24 1 Yes Yes 3 4 2 1
R:R:G222 R:R:Y195 2.9 1 No Yes 3 4 2 1
R:R:K244 R:R:Y195 5.97 1 Yes Yes 3 4 1 1
H:H:?1 R:R:Y195 4.18 1 Yes Yes 0 4 1 1
R:R:G223 R:R:N198 3.39 1 No Yes 7 7 1 2
H:H:?1 R:R:N198 24.5 1 Yes Yes 0 7 1 2
R:R:K201 R:R:Y225 10.75 0 No No 4 4 2 1
R:R:D217 R:R:K218 4.15 1 No Yes 5 4 2 1
R:R:D217 R:R:D219 9.31 1 No Yes 5 3 2 2
R:R:D219 R:R:K218 19.36 1 Yes Yes 3 4 2 1
R:R:D219 R:R:K244 4.15 1 Yes Yes 3 3 2 1
R:R:G222 R:R:K244 5.23 1 No Yes 3 3 2 1
R:R:E247 R:R:S243 2.87 1 Yes Yes 4 5 1 1
R:R:S243 R:R:S268 6.52 1 Yes No 5 5 1 1
R:R:E247 R:R:G245 3.27 1 Yes No 4 9 1 1
R:R:H248 R:R:H271 15.53 0 No No 4 5 1 2
R:R:L267 R:R:P264 4.93 0 No No 5 9 1 2
R:R:F269 R:R:S268 2.64 1 Yes No 7 5 2 1
H:H:?1 H:H:?2 38.55 1 Yes No 0 0 1 1
R:R:L267 R:R:S266 1.5 0 No No 5 5 1 2
R:R:L267 W:W:T65 1.47 0 No No 5 0 1 0

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

ShowSimilarityNetwork TypeNameLigandDescription
75.00Single7UTZTR14027UTZ-TSH-TR1402-PubChem 644078-Gs/&β;1/&γ;2
60.00Single7T9ITSH7T9I-TSH-TSH-Gs/&β;1/&γ;2
40.00Single6O3CCholesterol6O3C-SMO-SAG21k-Cholesterol
33.33Single5L7DCholesterol5L7D-SMO-Cholesterol
33.33Single6D32Cyclopamine6D32-SMO-Cyclopamine-Cyclopamine
33.33Single6D35Cholesterol6D35-SMO-Cholesterol
33.33Single6N51Quisqualate6N51-mGlu5; mGlu5-Quisqualate
33.33Single6N51Quisqualate6N51-mGlu5; mGlu5-Quisqualate
33.33Single6UO8SKF975416UO8-GABAB1, GABAB2-SKF97541-GS39783
33.33Single6UO9SKF975416UO9-GABAB1, GABAB2-SKF97541
33.33Single6W2XPubChem 53110426W2X-GABAB1, GABAB2-PubChem 5311042-PubChem 23727970
33.33Single6W2YPubChem 53110426W2Y-GABAB1; GABAB1-PubChem 5311042-PubChem 23727970
33.33Single6W2YPubChem 53110426W2Y-GABAB1; GABAB1-PubChem 5311042-PubChem 23727970
33.33Single7C7QBaclofen7C7Q-GABAB1, GABAB2-Baclofen-PubChem 7023848
33.33Single7C7SCGP546267C7S-GABAB1, GABAB2-CGP54626
33.33Single7CUMCGP546267CUM-GABAB1, GABAB2-CGP54626-Phospholipid
33.33Single7DD5Ca37DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
33.33Single7DD5Ca7DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
33.33Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
33.33Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
33.33Single7DGEQuisqualate7DGE-mGlu1; mGlu1-Quisqualate
33.33Single7DTTCa7DTT-CaS-Ca-Ca
33.33Single7DTTCa7DTT-CaS-Ca-Ca
33.33Single7DTUTryptophan7DTU-CaS-Tryptophan
33.33Single7DTUTryptophan7DTU-CaS-Tryptophan
33.33Single7DTVCa7DTV-CaS-Ca-Ca; Tryptophan
33.33Single7DTVCa; Tryptophan7DTV-CaS-Ca-Ca; Tryptophan
33.33Single7DTVCa7DTV-CaS-Ca-Ca; Tryptophan
33.33Single7DTVCa; Tryptophan7DTV-CaS-Ca-Ca; Tryptophan
33.33Single7E6TCa7E6T-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
33.33Single7E6TCa; Ca; Cyclomethyltryptophan; PO47E6T-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
33.33Single7E6TCa7E6T-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
33.33Single7E6TCa; Ca; Cyclomethyltryptophan; PO47E6T-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
33.33Single7E9GEglumetad7E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/&β;1/&γ;2
33.33Single7E9GEglumetad7E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/&β;1/&γ;2
33.33Single7E9HPhosphoserine7E9H-mGlu4; mGlu4-Phosphoserine-Gi3/&β;1/&γ;2
33.33Single7E9HPhosphoserine7E9H-mGlu4; mGlu4-Phosphoserine-Gi3/&β;1/&γ;2
33.33Single7EB2Baclofen7EB2-GABAB1, GABAB2-Baclofen-rac-BHFF-Gi1/&β;1/&γ;2
33.33Single7EPBEglumetad7EPB-mGlu2; mGlu2-Eglumetad
33.33Single7EPBEglumetad7EPB-mGlu2; mGlu2-Eglumetad
33.33Single7FD8Quisqualate7FD8-mGlu5; mGlu5-Quisqualate
33.33Single7FD8Quisqualate7FD8-mGlu5; mGlu5-Quisqualate
33.33Single7FD9LY3414957FD9-mGlu5; mGlu5-LY341495
33.33Single7FD9LY3414957FD9-mGlu5; mGlu5-LY341495
33.33Single7FIHhCG7FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/&β;1/&γ;2
33.33Single7FIIhCG7FII-LH-hCG-6fuf
33.33Single7M3ECa; Ca; Tryptophan; NPS-2143; PO47M3E-CaS-Ca; Ca; Tryptophan; NPS-2143; PO4
33.33Single7M3ECa; Ca; Tryptophan; NPS-2143; PO47M3E-CaS-Ca; Ca; Tryptophan; NPS-2143; PO4
33.33Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
33.33Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
33.33Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
33.33Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
33.33Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
33.33Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
33.33Single7MTQLY3414957MTQ-mGlu2; mGlu2-LY341495
33.33Single7MTQLY3414957MTQ-mGlu2; mGlu2-LY341495
33.33Single7MTRGlutamate7MTR-mGlu2; mGlu2-Glutamate-ADX55164
33.33Single7MTRGlutamate7MTR-mGlu2; mGlu2-Glutamate-ADX55164
33.33Single7MTSGlutamate7MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/&β;1/&γ;2
33.33Single7MTSGlutamate7MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/&β;1/&γ;2
33.33Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
33.33Single7SILCa7SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
33.33Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
33.33Single7SILCa7SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
33.33Single7SIMCa7SIM-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
33.33Single7SIMCa; Ca; Cyclomethyltryptophan; PO47SIM-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
33.33Single7SIMCa7SIM-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
33.33Single7SIMCa; Ca; Cyclomethyltryptophan; PO47SIM-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
33.33Single7T9NM22 Fab7T9N-TSH-M22 Fab-PubChem 644078-Gs/&β;1/&γ;2
33.33Single7WI6LY3414957WI6-mGlu3; mGlu3-LY341495
33.33Single7WI6LY3414957WI6-mGlu3; mGlu3-LY341495
33.33Single7WI8LY3414957WI8-mGlu3; mGlu3-LY341495
33.33Single7WI8LY3414957WI8-mGlu3; mGlu3-LY341495
33.33Single7WIHLY27941937WIH-mGlu3; mGlu3-LY2794193
33.33Single7WIHLY27941937WIH-mGlu3; mGlu3-LY2794193
33.33Single7XW6M22 Fab7XW6-TSH-M22 Fab-ML109-Gs/&β;1/&γ;2
33.33Single7XW7K1-707XW7-TSH-K1-70
33.33Single8I2GGlycoprotein hormones alpha chain8I2G-FSH-Glycoprotein hormones alpha chain-Compound 716340-Gs/&β;1/&γ;2
33.33Single8JCULY3414958JCU-mGlu2; mGlu3-LY341495
33.33Single8JCULY3414958JCU-mGlu2; mGlu3-LY341495
33.33Single8JCVLY3414958JCV-mGlu2; mGlu3-LY341495
33.33Single8JCVLY3414958JCV-mGlu2; mGlu3-LY341495
33.33Single8JCWLY3414958JCW-mGlu2; mGlu3-LY341495
33.33Single8JCWLY3414958JCW-mGlu2; mGlu3-LY341495
33.33Single8JCXLY3414958JCX-mGlu2; mGlu3-LY341495
33.33Single8JCXLY3414958JCX-mGlu2; mGlu3-LY341495
33.33Single8JCYLY3414958JCY-mGlu2; mGlu3-LY341495
33.33Single8JCYLY3414958JCY-mGlu2; mGlu3-LY341495
33.33Single8JCZLY3414958JCZ-mGlu2; mGlu3-LY341495
33.33Single8JCZLY3414958JCZ-mGlu2; mGlu3-LY341495
33.33Single8JD0Glutamate8JD0-mGlu2; mGlu3-Glutamate-J9R
33.33Single8JD1Glutamate8JD1-mGlu2; mGlu3-Glutamate
33.33Single8JD1Glutamate8JD1-mGlu2; mGlu3-Glutamate
33.33Single8JD2Glutamate8JD2-mGlu2; mGlu3-Glutamate
33.33Single8JD2Glutamate8JD2-mGlu2; mGlu3-Glutamate
33.33Single8JD3Glutamate8JD3-mGlu2; mGlu3-Glutamate-HZR; PEF-Gi1/&β;1/&γ;2
33.33Single8JD3Glutamate8JD3-mGlu2; mGlu3-Glutamate-HZR; PEF-Gi1/&β;1/&γ;2
33.33Single8JD4Glutamate8JD4-mGlu2; mGlu4-Glutamate
33.33Single8JD4Glutamate8JD4-mGlu2; mGlu4-Glutamate
33.33Single8JD5Glutamate8JD5-mGlu2; mGlu4-Glutamate-BQI; HZE; PEF-Gi1/&β;1/&γ;2
33.33Single8JD5Glutamate8JD5-mGlu2; mGlu4-Glutamate-BQI; HZE; PEF-Gi1/&β;1/&γ;2
33.33Single8JD6Phosphoserine8JD6-mGlu4; mGlu4-Phosphoserine-N-(3-chlorophenyl)pyridine-2-carboxamide-Gi3/&β;1/&γ;2
33.33Single8JD6Phosphoserine8JD6-mGlu4; mGlu4-Phosphoserine-N-(3-chlorophenyl)pyridine-2-carboxamide-Gi3/&β;1/&γ;2
33.33Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
33.33Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
33.33Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
33.33Single8SZGCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-chim(NtGi1-Gq)/&β;1/&γ;2
33.33Single8SZGCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-chim(NtGi1-Gq)/&β;1/&γ;2
33.33Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/&β;1/&γ;2
33.33Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/&β;1/&γ;2
33.33Single8SZICa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZI-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi3/&β;1/&γ;2
33.33Single8SZICa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZI-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi3/&β;1/&γ;2
33.33Single8T7HQuisqualate8T7H-mGlu5; mGlu5-Quisqualate
33.33Single8T7HQuisqualate8T7H-mGlu5; mGlu5-Quisqualate
33.33Single8T8MQuisqualate8T8M-mGlu5; mGlu5-Quisqualate
33.33Single8T8MQuisqualate8T8M-mGlu5; mGlu5-Quisqualate
33.33Single8TAOQuisqualate8TAO-mGlu5; mGlu5-Quisqualate-CDPPB
33.33Single8TAOQuisqualate8TAO-mGlu5; mGlu5-Quisqualate-CDPPB
33.33Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
33.33Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
33.33Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
33.33Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
33.33Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
33.33Single9AXFCa9AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
33.33Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
33.33Single9AXFCa9AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
33.33Single9AYFCa9AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/&β;1/&γ;2
33.33Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/&β;1/&γ;2
33.33Consensusclass-c_offOrthosteric Ligandgabab_off mglu_off
33.33Consensusclass-c_offOrthosteric Ligandgabab_off mglu_off
33.33Consensusclass-c_onOrthosteric Ligandgabab_on mglu_on
33.33Consensusclass-c_onOrthosteric Ligandgabab_on mglu_on
33.33Consensusfsh_on_alloOrthosteric Ligand8I2G-FSH-Glycoprotein hormones alpha chain-Compound 716340-Gs/&β;1/&γ;2
33.33Consensusgabab_offOrthosteric Ligand7C7S-GABAB1, GABAB2-CGP54626 7CUM-GABAB1, GABAB2-CGP54626-Phospholipid 6W2X-GABAB1, GABAB2-PubChem 5311042-PubChem 23727970
33.33Consensusgabab_onOrthosteric Ligand7EB2-GABAB1, GABAB2-Baclofen-rac-BHFF-Gi1/&β;1/&γ;2
33.33Consensusgi_class-cOrthosteric Ligandgi_mglu gi_gaba
33.33Consensusgi_class-cOrthosteric Ligandgi_mglu gi_gaba
33.33Consensusgi_gabaOrthosteric Ligand7EB2-GABAB1, GABAB2-Baclofen-rac-BHFF-Gi1/&β;1/&γ;2
33.33Consensusgi_mgluOrthosteric Ligand7E9H-mGlu4; mGlu4-Phosphoserine-Gi3/&β;1/&γ;2 8JD6-mGlu4; mGlu4-Phosphoserine-N-(3-chlorophenyl)pyridine-2-carboxamide-Gi3/&β;1/&γ;2
33.33Consensusgi_mgluOrthosteric Ligand7E9H-mGlu4; mGlu4-Phosphoserine-Gi3/&β;1/&γ;2 8JD6-mGlu4; mGlu4-Phosphoserine-N-(3-chlorophenyl)pyridine-2-carboxamide-Gi3/&β;1/&γ;2
33.33Consensusgphr_onOrthosteric Ligandlh_on tsh_on
33.33Consensusgs_gphrOrthosteric Ligand7T9I-TSH-TSH-Gs/&β;1/&γ;2 7FIG-LH-hCG-chim(NtGi1L-Gs)/&β;1/&γ;2
33.33Consensusgs_proteinOrthosteric Ligandgs_gphr
33.33Consensuslh_onOrthosteric Ligand7FIG-LH-hCG-chim(NtGi1L-Gs)/&β;1/&γ;2
33.33Consensuslh_on_alloOrthosteric Ligand7FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/&β;1/&γ;2
33.33Consensusmglu2_offOrthosteric Ligand7MTQ-mGlu2; mGlu2-LY341495
33.33Consensusmglu2_offOrthosteric Ligand7MTQ-mGlu2; mGlu2-LY341495
33.33Consensusmglu2_onOrthosteric Ligand7MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/&β;1/&γ;2 7E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/&β;1/&γ;2
33.33Consensusmglu2_onOrthosteric Ligand7MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/&β;1/&γ;2 7E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/&β;1/&γ;2
33.33Consensusmglu3_offOrthosteric Ligand7WI8-mGlu3; mGlu3-LY341495 7WIH-mGlu3; mGlu3-LY2794193
33.33Consensusmglu3_offOrthosteric Ligand7WI8-mGlu3; mGlu3-LY341495 7WIH-mGlu3; mGlu3-LY2794193
33.33Consensusmglu4_onOrthosteric Ligand7E9H-mGlu4; mGlu4-Phosphoserine-Gi3/&β;1/&γ;2 8JD6-mGlu4; mGlu4-Phosphoserine-N-(3-chlorophenyl)pyridine-2-carboxamide-Gi3/&β;1/&γ;2
33.33Consensusmglu4_onOrthosteric Ligand7E9H-mGlu4; mGlu4-Phosphoserine-Gi3/&β;1/&γ;2 8JD6-mGlu4; mGlu4-Phosphoserine-N-(3-chlorophenyl)pyridine-2-carboxamide-Gi3/&β;1/&γ;2
33.33Consensusmglu5_offOrthosteric Ligand7FD9-mGlu5; mGlu5-LY341495
33.33Consensusmglu5_offOrthosteric Ligand7FD9-mGlu5; mGlu5-LY341495
33.33Consensusmglu_offOrthosteric Ligandmglu2_off mglu3_off mglu5_off
33.33Consensusmglu_offOrthosteric Ligandmglu2_off mglu3_off mglu5_off
33.33Consensusmglu_onOrthosteric Ligandmglu2_on mglu4_on
33.33Consensusmglu_onOrthosteric Ligandmglu2_on mglu4_on
33.33Consensussmo_off_alloOther Ligand6D32-SMO-Cyclopamine-Cyclopamine
33.33Consensustsh_onOrthosteric Ligand7T9I-TSH-TSH-Gs/&β;1/&γ;2
33.33Consensustsh_on_alloOrthosteric Ligand7XW5-TSH-TSH-ML109-Gs/&β;1/&γ;2
25.00Single7DD6Ca7DD6-CaS-Ca-Ca; Ca; Tryptophan
25.00Single7DD6Ca; Ca; Tryptophan7DD6-CaS-Ca-Ca; Ca; Tryptophan
25.00Single7DD6Ca7DD6-CaS-Ca-Ca; Ca; Tryptophan
25.00Single7DD6Ca; Ca; Tryptophan7DD6-CaS-Ca-Ca; Ca; Tryptophan
25.00Single7DD7Ca7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
25.00Single7DD7Ca7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
25.00Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
25.00Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
25.00Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/&β;1/&γ;2
25.00Single9AYFCa9AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/&β;1/&γ;2
20.00Single7KNUCalcitonin gene-related peptide-17KNU-CT Like-Calcitonin gene-related peptide-1-RAMP1
20.00Single8HS2Fab0468HS2-GPR20-Fab046
16.67Single7FIGhCG7FIG-LH-hCG-chim(NtGi1L-Gs)/&β;1/&γ;2
16.67Single7XW5TSH7XW5-TSH-TSH-ML109-Gs/&β;1/&γ;2
16.67Single7ZI0Cholesterol7ZI0-SMO-SAG-Cholesterol
14.29Single8HSCFab0468HSC-GPR20-Fab046-Gi1/&β;1/&γ;2
13.64Single4XT3Fractalkine4XT3-US28-Fractalkine
12.50Single6XBM25(S)-Epoxycholesterol6XBM-SMO-25(S)-Epoxycholesterol-Gi1/&β;1/&γ;2
12.50Single8U4QREGN7663-Fab8U4Q-CXCR4-REGN7663-Fab-Cholesterol-Gi1/&β;1/&γ;2
11.76Single7RKFFractalkine7RKF-US28-Fractalkine-GDP-chim(NtGi1-G11)/&β;1/&γ;2
11.11Single4XNWMRS25004XNW-P2Y1-MRS2500
11.11Single6D32Cyclopamine6D32-SMO-Cyclopamine-Cyclopamine
11.11Single6LI0GTPL98046LI0-GPR52-GTPL9804
11.11Single8JRVGlucagon8JRV-Glucagon-Glucagon-Arrestin2
11.11Consensusp2y1_offOrthosteric Ligand4XNW-P2Y1-MRS2500
11.11Consensussmo_off_alloOrthosteric Ligand6D32-SMO-Cyclopamine-Cyclopamine
10.00Single3V2WPubChem 518926453V2W-S1P1-PubChem 51892645
10.00Single4O9RCyclopamine4O9R-SMO-Cyclopamine
10.00Single7VDHC48/807VDH-MRGPRX2-C48/80-Gi1/&β;1/&γ;2
10.00Single8U4RREGN7663-Fab8U4R-CXCR4-REGN7663-Fab-Cholesterol
10.00Consensusgo_chemokineOrthosteric Ligand6WWZ-CCR6-CCL20-Go/&β;1/&γ;2
10.00Consensusgo_proteinOrthosteric Ligandgo_chemokine
10.00Consensussmo_on_alloOrthosteric Ligand6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
9.09Single4BWBNeurotensin4BWB-NTS1-Neurotensin
9.09Single4QINSAG1.54QIN-SMO-SAG1.5
9.09Single5U09Taranabant5U09-CB1-Taranabant
9.09Single6LFOInterleukin-86LFO-CXCR2-Interleukin-8-Gi1/&β;1/&γ;2
9.09Single6O3CSAG21k6O3C-SMO-SAG21k-Cholesterol
9.09Single6PWCNeurotensin6PWC-NTS1-Neurotensin-Arrestin2
9.09Single6WWZCCL206WWZ-CCR6-CCL20-Go/&β;1/&γ;2
9.09Single7BR3Elagolix7BR3-GnRH1-Elagolix
9.09Single7LCJDanuglipron7LCJ-GLP-1-Danuglipron
9.09Single7VIHCBP-3077VIH-S1P1-CBP-307-Gi1/&β;1/&γ;2
9.09Single7VV5C48/807VV5-MRGPRX2-C48/80-Gi1/&β;1/&γ;2
9.09Single7WF7S1P7WF7-S1P1-S1P-Gi1/&β;1/&γ;2
9.09Single8FN0Neurotensin/neuromedin N8FN0-NTS1-Neurotensin/neuromedin N-PubChem 118610427-chim(NtGi1-Go)/&β;1/&γ;2
9.09Single8HMPPubChem 699214798HMP-GPR52-PubChem 69921479-Gs/&β;1/&γ;2
9.09Consensusccr6_onOrthosteric Ligand6WWZ-CCR6-CCL20-Go/&β;1/&γ;2
9.09Consensusclass-f_offOrthosteric Ligandsmo_off
9.09Consensuscxcr1_onOrthosteric Ligand8IC0-CXCR1-Interleukin-8-Gi1/&β;1/&γ;2
9.09Consensusgnrh1_offOrthosteric Ligand7BR3-GnRH1-Elagolix
9.09Consensusp2y_offOrthosteric Ligandp2y1_off p2y12_off
8.33Single3V2YPubChem 518926453V2Y-S1P1-PubChem 51892645
8.33Single6XBLSAG6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
8.33Single7C2EPubChem 1490507997C2E-GLP-1-PubChem 149050799-Gs/&β;1/&γ;2
8.33Single7UTZPubChem 6440787UTZ-TSH-TR1402-PubChem 644078-Gs/&β;1/&γ;2
8.33Single7VV6C48/807VV6-MRGPRX2-C48/80
8.33Single7XXH2MeSADP7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/&β;1/&γ;2
8.33Single7ZI0SAG7ZI0-SMO-SAG-Cholesterol
8.33Single8H4LDoconexent8H4L-FFA4-Doconexent-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
8.33Consensuscb1_offOrthosteric Ligand5TGZ-CB1-AM6538 5U09-CB1-Taranabant
8.33Consensuscxcr2_onOrthosteric Ligand6LFM-CXCR2-Interleukin-8-Gi1/&β;1/&γ;2
8.33Consensuscxcr_onOrthosteric Ligandcxcr1_on cxcr2_on
8.33Consensusgi_class-fOrthosteric Ligandgi_frizzled
8.33Consensusgi_frizzledOrthosteric Ligand6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
8.33Consensusgnrh_offOrthosteric Ligandgnrh1_off
8.33Consensuslh_on_alloOther Ligand7FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/&β;1/&γ;2
8.33Consensuss1p1_offOrthosteric Ligand3V2Y-S1P1-PubChem 51892645
8.33Consensuss1p_offOrthosteric Ligands1p1_off
7.69Single4QIMPubChem 249053754QIM-SMO-PubChem 24905375
7.69Single5T04Neurotensin5T04-NTS1-Neurotensin
7.69Single5TGZAM65385TGZ-CB1-AM6538
7.69Single6D27CAY104716D27-DP2-CAY10471
7.69Single6X1ADanuglipron6X1A-GLP-1-Danuglipron-Gs/&β;1/&γ;2
7.69Single6XBM25(S)-Epoxycholesterol6XBM-SMO-25(S)-Epoxycholesterol-Gi1/&β;1/&γ;2
7.69Single6Z4VNTS8-136Z4V-NTS1-NTS8-13
7.69Single7FIHOrg435537FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/&β;1/&γ;2
7.69Single7LCIDanuglipron7LCI-GLP-1-Danuglipron-Gs/&β;1/&γ;2
7.69Single7LCKDanuglipron7LCK-GLP-1-Danuglipron
7.69Single7S15PubChem 1346112237S15-GLP-1-PubChem 134611223
7.69Single7SK8CXCL127SK8-ACKR3-CXCL12-CCX662
7.69Single7VIES1P7VIE-S1P1-S1P-Gi1/&β;1/&γ;2
7.69Single7VIF(S)-FTY720-P7VIF-S1P1-(S)-FTY720-P-Gi1/&β;1/&γ;2
7.69Single7YU4ONO-07405567YU4-LPA1-ONO-0740556
7.69Single8IC0Interleukin-88IC0-CXCR1-Interleukin-8-Gi1/&β;1/&γ;2
7.69Single8ID4Linoleic acid8ID4-FFA4 (GPR120)-Linoleic acid-Gi1/&β;1/&γ;2
7.69Consensusfsh_on_alloOther Ligand8I2G-FSH-Glycoprotein hormones alpha chain-Compound 716340-Gs/&β;1/&γ;2
7.69Consensuslipid_offOrthosteric Ligandcannabinoid_off leuko_off lpl_off paf_off prostanoid_off
7.69Consensusnucleotide_offOrthosteric Ligandadenosine_off p2y_off
7.69Consensussmo_offOrthosteric Ligand5L7I-SMO-Vismodegib 4O9R-SMO-Cyclopamine 4QIM-SMO-PubChem 24905375 4JKV-SMO-Taladegib (LY2940680)
7.14Single4JKVTaladegib (LY2940680)4JKV-SMO-Taladegib (LY2940680)
7.14Single5C1MBU725C1M-μ-BU72
7.14Single6LFMInterleukin-86LFM-CXCR2-Interleukin-8-Gi1/&β;1/&γ;2
7.14Single6XBKCholesterol6XBK-SMO-Cholesterol-Gi1/&β;1/&γ;2
7.14Single7BB7Acyclovir triphosphate7BB7-V2-Acyclovir triphosphate-Gs/&β;1/&γ;2
7.14Single7C4SS1P7C4S-S1P3-S1P
7.14Single7EO2FTY720-P7EO2-S1P1-FTY720-P-Gi1/&β;1/&γ;2
7.14Single7EW3S1P7EW3-S1P3-S1P-Gi1/&β;1/&γ;2
7.14Single7T9NPubChem 6440787T9N-TSH-M22 Fab-PubChem 644078-Gs/&β;1/&γ;2
7.14Single7TD3S1P7TD3-S1P1-S1P-Gi1/&β;1/&γ;2
7.14Single7YU3ONO-07405567YU3-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
7.14Single7YU6ONO-07405567YU6-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
7.14Single7YU7ONO-07405567YU7-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
7.14Single7YXAONO-54306087YXA-S1P5-ONO-5430608
7.14Single8FN1Neurotensin/neuromedin N8FN1-NTS1-Neurotensin/neuromedin N-chim(NtGi1-Go)/&β;1/&γ;2
7.14Single8JPCNeurotensin 8-138JPC-NTS1-Neurotensin 8-13-PubChem 118610427; GDP; Mg-Gq; GRK2
6.90Single9AUCCalcitonin gene-related peptide-19AUC-CT-Calcitonin gene-related peptide-1-Gs/&β;1/&γ;2; RAMP1
6.67Single3ZEVNeurotensin3ZEV-NTS1-Neurotensin
6.67Single4BV0Neurotensin4BV0-NTS1-Neurotensin
6.67Single4Z34ONO-97803074Z34-LPA1-ONO-9780307
6.67Single5V56TC1145V56-SMO-TC114
6.67Single5V57TC1145V57-SMO-TC114
6.67Single6OS1TRV0266OS1-AT1-TRV026
6.67Single6UP7Neurotensin6UP7-NTS1-Neurotensin-Arrestin2
6.67Single7EW1Siponimod7EW1-S1P5-Siponimod-Gi1/&β;1/&γ;2
6.67Single7F1TMIP-1a7F1T-CCR5-MIP-1a
6.67Single7F58THIQ7F58-MC4-THIQ-Gs/&β;1/&γ;2
6.67Single7L0PNeurotensin7L0P-NTS1-Neurotensin-Gi1/&β;1/&γ;1
6.67Single7L0QNeurotensin7L0Q-NTS1-Neurotensin-Gi1/&β;1/&γ;1
6.67Single7R0CAcyclovir triphosphate7R0C-V2-Acyclovir triphosphate-Arrestin2
6.67Single7SK7CXCL127SK7-ACKR3-CXCL12-CCX662
6.67Single7TD1LPA7TD1-LPA1-LPA-Gi1/&β;1/&γ;2
6.67Single7VIGCBP-3077VIG-S1P1-CBP-307-Gi1/&β;1/&γ;2
6.67Single7YU5ONO-07405567YU5-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
6.67Single8E0GBU728E0G-μ-BU72
6.67Single8FMZNeurotensin/neuromedin N8FMZ-NTS1-Neurotensin/neuromedin N-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
6.67Single8HQCC5a anaphylatoxin8HQC-C5a1-C5a anaphylatoxin-Go/&β;1/&γ;2
6.67Single8I2GCompound 7163408I2G-FSH-Glycoprotein hormones alpha chain-Compound 716340-Gs/&β;1/&γ;2
6.67Single8ID39-Hydroxystearic acid8ID3-FFA4 (GPR120)-9-Hydroxystearic acid-Gi1/&β;1/&γ;2
6.67Single8ID6Oleic acid8ID6-FFA4 (GPR120)-Oleic acid-Gi1/&β;1/&γ;2
6.67Consensusarrestin2Orthosteric Ligand6TKO-β1-Arformoterol-Arrestin2 6PWC-NTS1-Neurotensin-Arrestin2 7R0C-V2-Acyclovir triphosphate-Arrestin2
6.67Consensusclass-a_offOrthosteric Ligandsensory_off amine_off lipid_off nucleotide_off peptide_off protein_off hcar_off
6.67Consensuslpa1_onOrthosteric Ligand7TD0-LPA1-LPA-Gi1/&β;1/&γ;2 7YU3-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
6.67Consensuslpa_offOrthosteric Ligandlpa1_off
6.67Consensuslpa_onOrthosteric Ligandlpa1_on
6.67Consensuss1p3_onOrthosteric Ligand7EW3-S1P3-S1P-Gi1/&β;1/&γ;2 7EW4-S1P3-CYM5541-Gi1/&β;1/&γ;2 7EW2-S1P3-Fingolimod-Gi1/&β;1/&γ;2
6.67Consensuss1p5_onOrthosteric Ligand7EW1-S1P5-Siponimod-Gi1/&β;1/&γ;2
6.25Single4GRVNeurotensin 8-134GRV-NTS1-Neurotensin 8-13
6.25Single4XEENeurotensin4XEE-NTS1-Neurotensin
6.25Single4XESNeurotensin4XES-NTS1-Neurotensin
6.25Single6KPGAM8416KPG-CB1-AM841-Gi1/&β;1/&γ;2
6.25Single6OS0Angiotensinogen6OS0-AT1-Angiotensinogen
6.25Single6OS2TRV0266OS2-AT1-TRV026
6.25Single6OSAJMV4496OSA-NTS1-JMV449-Gi1/&β;1/&γ;2
6.25Single6XOXOrforglipron6XOX-GLP-1-Orforglipron-chim(NtGi1-Gs)/&β;1/&γ;2
6.25Single6YVRNTS8-136YVR-NTS1-NTS8-13
6.25Single7EVYSiponimod7EVY-S1P1-Siponimod-Gi1/&β;1/&γ;2
6.25Single7EW2Fingolimod7EW2-S1P3-Fingolimod-Gi1/&β;1/&γ;2
6.25Single7L0SNeurotensin7L0S-NTS1-Neurotensin-Gi1/&β;1/γ1
6.25Single7W0NElabela7W0N-Apelin-Elabela-Gi1/&β;1/&γ;2
6.25Single7XW5ML1097XW5-TSH-TSH-ML109-Gs/&β;1/&γ;2
6.25Single8IBUErythromycin A8IBU-Motilin-Erythromycin A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
6.25Single8JPBNeurotensin 8-138JPB-NTS1-Neurotensin 8-13-PubChem 118610427; GDP; Mg-Gq; GRK2
6.25Single8T3QDHA8T3Q-FFA4-DHA-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
6.25Single8U26Protachykinin-18U26-NK1-Protachykinin-1-Gs/&β;1/&γ;2
6.25Consensuscannabinoid_offOrthosteric Ligandcb1_off cb2_off
6.25Consensuschemokine_offOrthosteric Ligandcxcr_off
6.25Consensuscxcr4_offOrthosteric Ligand4RWS-CXCR4-vMIP-II
6.25Consensuscxcr_offOrthosteric Ligandcxcr4_off
6.25Consensusdp2_offOrthosteric Ligand6D27-DP2-CAY10471 6D26-DP2-Fevipiprant
6.25Consensusdp_offOrthosteric Liganddp2_off
6.25Consensuslpa1_offOrthosteric Ligand4Z36-LPA1-ONO-3080573 4Z34-LPA1-ONO-9780307 4Z35-LPA1-ONO-9910539 7YU4-LPA1-ONO-0740556
6.25Consensusmop_onOrthosteric Ligand8F7Q-μ-Beta-endorphin-Gi1/&β;1/&γ;2 8EFQ-μ-Damgo-Gi1/&β;1/&γ;2 8F7R-μ-Endomorphin-Gi1/&β;1/&γ;2 8EF5-μ-Fentanyl-Gi1/&β;1/&γ;2 8EF6-μ-Morphine-Gi1/&β;1/&γ;2 8EFB-μ-Oliceridine-Gi1/&β;1/&γ;2 8EFO-μ-PZM21-Gi1/&β;1/&γ;2 8EFL-μ-SR17018-Gi1/&β;1/&γ;2
6.25Consensusnts1_onOrthosteric Ligand6OS9-NTS1-JMV449-Gi1/&β;1/&γ;2
6.25Consensusnts_onOrthosteric Ligandnts1_on
6.25Consensuss1p_onOrthosteric Ligands1p3_on s1p5_on s1p1_on s1p2_on
6.25Consensustsh_on_alloOther Ligand7XW5-TSH-TSH-ML109-Gs/&β;1/&γ;2
5.88Single4BUONeurotensin4BUO-NTS1-Neurotensin
5.88Single4RWSvMIP-II4RWS-CXCR4-vMIP-II
5.88Single4Z35ONO-99105394Z35-LPA1-ONO-9910539
5.88Single6M1HMaxadilan6M1H-PAC1-Maxadilan-Gs/&β;1/&γ;2
5.88Single6OS9JMV4496OS9-NTS1-JMV449-Gi1/&β;1/&γ;2
5.88Single7EVZCenerimod7EVZ-S1P1-Cenerimod-Gi1/&β;1/&γ;2
5.88Single7EW0Ozanimod7EW0-S1P1-Ozanimod-Gi1/&β;1/&γ;2
5.88Single7LLLExendin-47LLL-GLP-1-Exendin-4-Gs/&β;1/&γ;2
5.88Single7P00Substance P7P00-NK1-Substance P-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
5.88Single7X8RBOC57X8R-GLP-1-BOC5-Gs/&β;1/&γ;2
5.88Single7YU8ONO-07405567YU8-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
5.88Single8IYSTUG-8918IYS-FFA4-TUG-891-GDP-chim(NtGi1L-Gq)/&β;1/&γ;2
5.88Single8JPFNeurotensin8JPF-NTS1-Neurotensin-PubChem 118610427
5.88Consensusclass-a_onOrthosteric Ligandsensory_on amine_on lipid_on nucleotide_on peptide_on protein_on hcar_on steroid_on melatonin_on
5.88Consensusgi_class-aOrthosteric Ligandgi_amine gi_lipid gi_melatonin gi_peptide gi_protein gi_nucleotide gi_hcar
5.88Consensusgi_neurotensinOrthosteric Ligand7L0P-NTS1-Neurotensin-Gi1/&β;1/&γ;1 6OS9-NTS1-JMV449-Gi1/&β;1/&γ;2
5.88Consensuss1p1_onOrthosteric Ligand7TD3-S1P1-S1P-Gi1/&β;1/&γ;2 7TD4-S1P1-Siponimod-Gi1/&β;1/&γ;2 7VIF-S1P1-(S)-FTY720-P-Gi1/&β;1/&γ;2 7EO4-S1P1-BAF312-Gi1/&β;1/&γ;2 7VIG-S1P1-CBP-307-Gi1/&β;1/&γ;2 7EVZ-S1P1-Cenerimod-Gi1/&β;1/&γ;2 7EW0-S1P1-Ozanimod-Gi1/&β;1/&γ;2 7EW7-S1P1-PubChem 4077460-Gi1/&β;1/&γ;2
5.56Single6KNMJN241-96KNM-Apelin-JN241-9
5.56Single7RKNFractalkine7RKN-US28-Fractalkine-Gi1/&β;1/&γ;2
5.56Single7RMGSubstance P7RMG-NK1-Substance P-chim(Gs-CtGq)/&β;1/&γ;2
5.56Single7W2ZGhrelin7W2Z-Ghrelin-Ghrelin-Go/&β;1/&γ;2
5.56Single7X8SWB4-247X8S-GLP-1-WB4-24-Gs/&β;1/&γ;2
5.56Single8H4IDoconexent8H4I-FFA4-Doconexent-chim(NtGi1-Gs)/&β;1/&γ;2
5.56Single8JBFSenktide8JBF-NK3-Senktide-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
5.56Consensuschemokine_onOrthosteric Ligandcxcr_on cx3cr_on
5.56Consensusgi_apelinOrthosteric Ligand7W0P-Apelin-Elabela-Gi1/&β;1/&γ;2 7W0M-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
5.56Consensusgo_compl-peptideOrthosteric Ligand8I95-C3aB-EP54-Go/&β;1/&γ;2 8IA2-C5a1-C5a anaphylatoxin-Go/&β;1/&γ;2 8I9L-C3aB-C3a anaphylatoxin-Go/&β;1/&γ;2 8J6D-C3aB-EP141-Go/&β;1/&γ;2
5.56Consensusgo_ghrelinOrthosteric Ligand7W2Z-Ghrelin-Ghrelin-Go/&β;1/&γ;2
5.56Consensuslpl_offOrthosteric Ligands1p_off lpa_off
5.56Consensuslpl_onOrthosteric Ligands1p_on lpa_on
5.56Consensusmc4_onOrthosteric Ligand7F53-MC4-Alpha-MSH-Gs/&β;1/&γ;2 7F55-MC4-Bremelanotide-Gs/&β;1/&γ;2 7PIV-MC4-Setmelanotide-Gs/&β;1/&γ;2 7F58-MC4-THIQ-Gs/&β;1/&γ;2 7F54-MC4-Afamelanotide-Gs/&β;1/&γ;2
5.56Consensusmotilin_onOrthosteric Ligand8IBV-Motilin-Motilin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IBU-Motilin-Erythromycin A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
5.56Consensusnk1_onOrthosteric Ligand8U26-NK1-Protachykinin-1-Gs/&β;1/&γ;2 7P00-NK1-Substance P-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
5.56Consensusprotein_onOrthosteric Ligandccr_on chemokine_on gphr_on chemerin_on
5.26Single4XT1Fractalkine4XT1-US28-Fractalkine
5.26Single5VBLApelin Mimetic Peptide Agonist5VBL-Apelin-Apelin Mimetic Peptide Agonist
5.26Single6X19CHU-1286X19-GLP-1-CHU-128-Gs/&β;1/&γ;2
5.26Single7F54Afamelanotide7F54-MC4-Afamelanotide-Gs/&β;1/&γ;2
5.26Single7L0RNeurotensin7L0R-NTS1-Neurotensin-Gi1/&β;1/&γ;1
5.26Single7RMHSubstance P7RMH-NK1-Substance P-Gs/&β;1/&γ;2
5.26Single7RTBPeptide-197RTB-GLP-1-Peptide-19-Gs/&β;1/&γ;2
5.26Single7TD4Siponimod7TD4-S1P1-Siponimod-Gi1/&β;1/&γ;2
5.26Single7VLACCL15(27-92)7VLA-CCR1-CCL15(27-92)-Gi1/&β;1/&γ;2
5.26Single7W0PElabela7W0P-Apelin-Elabela-Gi1/&β;1/&γ;2
5.26Single8JIQPeptide-158JIQ-Glucagon-Peptide-15-Gs/&β;1/&γ;2
5.26Single8JZZC5a-desArg8JZZ-C5a1-C5a-desArg-Go/&β;1/&γ;2
5.26Single8U4OCXCL128U4O-CXCR4-CXCL12-Cholesterol-Gi1/&β;1/&γ;2
5.26Consensusapelin_onOrthosteric Ligand7W0P-Apelin-Elabela-Gi1/&β;1/&γ;2 7W0M-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
5.26Consensusgi_opioidOrthosteric Ligand8EF6-μ-Morphine-Gi1/&β;1/&γ;2 8F7Q-μ-Beta-endorphin-Gi1/&β;1/&γ;2 7U2K-μ-C6-guano-Gi1/&β;1/&γ;2 8EFQ-μ-Damgo-Gi1/&β;1/&γ;2 8F7S-δ-Deltorphin-Gi1/&β;1/&γ;2 8F7W-κ-Dynorphin-Gi1/&β;1/&γ;2 8F7R-μ-Endomorphin-Gi1/&β;1/&γ;2 8EF5-μ-Fentanyl-Gi1/&β;1/&γ;2 7SCG-μ-FH210-Gi1/&β;1/&γ;2 7T2H-μ-Lofentanil-Gi1/&β;1/&γ;2 7T2G-μ-Mitragynine pseudoindoxyl-Gi1/&β;1/&γ;2 8DZP-κ-momSalB-Gi1/&β;1/&γ;2 8F7X-NOP-Nociceptin-Gi1/&β;1/&γ;2 8EFB-μ-Oliceridine-Gi1/&β;1/&γ;2 8FEG-κ-PRD_002517-Gi1/&β;1/&γ;2 7U2L-μ-PubChem 163201242-Gi1/&β;1/&γ;2 8EFO-μ-PZM21-Gi1/&β;1/&γ;2 8EFL-μ-SR17018-Gi1/&β;1/&γ;2
5.26Consensusgo_class-aOrthosteric Ligandgo_amine go_peptide go_protein
5.26Consensusprotein_offOrthosteric Ligandccr_off chemokine_off gnrh_off
5.00Single6DO1Angiotensin-Like peptide S1I86DO1-AT1-Angiotensin-Like peptide S1I8
5.00Single6WHCGlu16 analog of GCG6WHC-Glucagon-Glu16 analog of GCG-Gs/&β;1/&γ;2
5.00Single7C6A(Sar1,Ile8)-Angiotensin II7C6A-AT2-(Sar1,Ile8)-Angiotensin II
5.00Single7E14Orforglipron7E14-GLP-1-Orforglipron-PubChem 156022738-Gs/&β;1/&γ;2
5.00Single7F1QMIP-1a7F1Q-CCR5-MIP-1a-Gi1/&β;1/&γ;2
5.00Single7PIVSetmelanotide7PIV-MC4-Setmelanotide-Gs/&β;1/&γ;2
5.00Single7RKMFractalkine7RKM-US28-Fractalkine-Gi1/&β;1/&γ;2
5.00Single7RMISubstance P7RMI-NK1-Substance P-chim(Gs-CtGq)/&β;1/&γ;2
5.00Single7SK5CXCL127SK5-ACKR3-CXCL12
5.00Single7VBINon-Acylated Tirzepatide7VBI-GLP-1-Non-Acylated Tirzepatide-Gs/&β;1/&γ;2
5.00Single8F7QBeta-endorphin8F7Q-μ-Beta-endorphin-Gi1/&β;1/&γ;2
5.00Single8IBVMotilin8IBV-Motilin-Motilin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
5.00Single8IOCGamma-MSH8IOC-MC3-Gamma-MSH-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
5.00Consensusgi_lplOrthosteric Ligand7EW3-S1P3-S1P-Gi1/&β;1/&γ;2 7TD4-S1P1-Siponimod-Gi1/&β;1/&γ;2 7VIF-S1P1-(S)-FTY720-P-Gi1/&β;1/&γ;2 7EO4-S1P1-BAF312-Gi1/&β;1/&γ;2 7VIG-S1P1-CBP-307-Gi1/&β;1/&γ;2 7EVZ-S1P1-Cenerimod-Gi1/&β;1/&γ;2 7EW4-S1P3-CYM5541-Gi1/&β;1/&γ;2 7EW2-S1P3-Fingolimod-Gi1/&β;1/&γ;2 7TD0-LPA1-LPA-Gi1/&β;1/&γ;2 7YU3-LPA1-ONO-0740556-Gi1/&β;1/&γ;2 7EW0-S1P1-Ozanimod-Gi1/&β;1/&γ;2 7EW7-S1P1-PubChem 4077460-Gi1/&β;1/&γ;2
5.00Consensusvasopressin-ot_onOrthosteric Ligandot_on v2_on
4.76Single3OE0CVX153OE0-CXCR4-CVX15
4.76Single6LW5WKYMVm6LW5-FPR2-ALX-WKYMVm
4.76Single7O7F(6P4)CCL57O7F-CCR5-(6P4)CCL5-Gi1/&β;1/&γ;1
4.76Single7TD0LPA7TD0-LPA1-LPA-Gi1/&β;1/&γ;2
4.76Single7TD2LPA7TD2-LPA1-LPA-Gi1/&β;1/&γ;2
4.76Single7VVNPTH7VVN-PTH1-PTH-Gs/&β;1/&γ;2
4.76Single7XA3CCL27XA3-CCR2-CCL2-Gi1/&β;1/&γ;2
4.76Single8XZHMM078XZH-Apelin-MM07-Gi1/&β;1/&γ;2
4.76Consensusangiotensin_onOrthosteric Ligandat1_on
4.76Consensusat1_onOrthosteric Ligand7F6G-AT1-SAR1-AngII-Gq/&β;1/&γ;2
4.76Consensusccr2_onOrthosteric Ligand7XA3-CCR2-CCL2-Gi1/&β;1/&γ;2
4.76Consensusccr_offOrthosteric Ligandccr5_off ccr8_off
4.76Consensusgo_peptideOrthosteric Ligandgo_opioid go_ghrelin go_compl-peptide go_galanin go_vasopressin
4.76Consensusgs_class-aOrthosteric Ligandgs_amine gs_nucleotide gs_lipid gs_peptide gs_protein gs_steroid
4.76Consensusgs_motilinOrthosteric Ligand8IBV-Motilin-Motilin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IBU-Motilin-Erythromycin A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
4.76Consensusgs_tachykininOrthosteric Ligand8U26-NK1-Protachykinin-1-Gs/&β;1/&γ;2 7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7P00-NK1-Substance P-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
4.76Consensusmc3_onOrthosteric Ligand8IOC-MC3-Gamma-MSH-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
4.76Consensusopioid_onOrthosteric Ligandkop_on mop_on nop_on dop_on
4.76Consensustachykinin_onOrthosteric Ligandnk1_on nk2_on
4.55Single5WB2CX3CL1.355WB2-US28-CX3CL1.35
4.55Single5YQZGlucagon analogue5YQZ-Glucagon-Glucagon analogue
4.55Single6M1IPACAP6M1I-PAC1-PACAP-Gs/&β;1/&γ;2
4.55Single6MEOEnvelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd46MEO-CCR5-Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4
4.55Single6METEnvelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd46MET-CCR5-Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4
4.55Single6WI9Secretin6WI9-Secretin-Secretin-Gs/&β;1/&γ;2
4.55Single7DW9Acyclovir triphosphate7DW9-V2-Acyclovir triphosphate-chim(NtGi1-Gs)/&β;1/&γ;2
4.55Single7F6GSAR1-AngII7F6G-AT1-SAR1-AngII-Gq/&β;1/&γ;2
4.55Single7FIMTirzepatide7FIM-GLP-1-Tirzepatide-Gs/&β;1/&γ;2
4.55Single7FINPeptide-20; GGL7FIN-GIP-Peptide-20; GGL-Gs/&β;1/&γ;2
4.55Single7RYCOxytocin7RYC-OT-Oxytocin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
4.55Single7YONPeptide YY(3-36)7YON-Y2-Peptide YY(3-36)-Gi1/&β;1/&γ;2
4.55Single8H4KGW95088H4K-FFA4-GW9508-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
4.55Single8HA0PTH8HA0-PTH1-PTH-chim(NtGi1-Gs)/&β;1/&γ;2
4.55Single8HNKCXCL118HNK-CXCR3-CXCL11-Gi1/&β;1/&γ;2
4.55Single8IA2C5a anaphylatoxin8IA2-C5a1-C5a anaphylatoxin-Go/&β;1/&γ;2
4.55Single8XZJWN3538XZJ-Apelin-WN353-Gi1/&β;1/&γ;2
4.55Consensusbk2_onOrthosteric Ligand7F2O-BK2-Bradykinin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7F6I-BK2-Kallidin-Gq/&β;1/&γ;2
4.55Consensusccr1_onOrthosteric Ligand7VL9-CCR1-CCL15(26-92)-Gi1/&β;1/&γ;2
4.55Consensuscompl-peptide_onOrthosteric Ligandc5a1_on c3a_on
4.55Consensusghrelin_onOrthosteric Ligand7W2Z-Ghrelin-Ghrelin-Go/&β;1/&γ;2 7F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7NA8-Ghrelin-PubChem 178024-Gi1/&β;1/&γ;2
4.55Consensusgo_class-bOrthosteric Ligandgo_class-b1 go_class-b2
4.55Consensusgq_angiotensinOrthosteric Ligand7F6G-AT1-SAR1-AngII-Gq/&β;1/&γ;2
4.55Consensuspca1_onOrthosteric Ligand6M1I-PAC1-PACAP-Gs/&β;1/&γ;2
4.55Consensusv2_onOrthosteric Ligand7DW9-V2-Acyclovir triphosphate-chim(NtGi1-Gs)/&β;1/&γ;2
4.35Single6UUNAdrenomedullin6UUN-CT Like (AM1)-Adrenomedullin-Gs/&β;1/&γ;2; RAMP2
4.35Single6X18GLP-16X18-GLP-1-GLP-1-Gs/&β;1/&γ;2
4.35Single7F6HBradykinin7F6H-BK2-Bradykinin-Gq/&β;1/&γ;2
4.35Single7F6IKallidin7F6I-BK2-Kallidin-Gq/&β;1/&γ;2
4.35Single7F9YGhrelin-287F9Y-Ghrelin-Ghrelin-28-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
4.35Single7LLYOxyntomodulin7LLY-GLP-1-Oxyntomodulin-Gs/&β;1/&γ;2
4.35Single7P02Protachykinin-17P02-NK1-Protachykinin-1-chim(NtGi1-Gs)/&β;1/&γ;2
4.35Single7TRYUrocortin7TRY-CRF2-Urocortin-chim(NtGi1-G11)/&β;1/&γ;2
4.35Single7VL9CCL15(26-92)7VL9-CCR1-CCL15(26-92)-Gi1/&β;1/&γ;2
4.35Single7WBJPACAP277WBJ-VPAC1-PACAP27-Gs/&β;1/&γ;2
4.35Single7X9BNeuropeptide Y7X9B-Y2-Neuropeptide Y-Gi1/&β;1/&γ;2
4.35Single7Y35Abaloparatide7Y35-PTH1-Abaloparatide-Gs/&β;1/&γ;2
4.35Single7Y64C5a anaphylatoxin7Y64-C5a1-C5a anaphylatoxin-Gi1/&β;1/&γ;2
4.35Single8E3YPACAP278E3Y-VPAC1-PACAP27-Gs/&β;1/&γ;2
4.35Single8E3ZVIP8E3Z-VPAC1-VIP-Gs/&β;1/&γ;2
4.35Single8HCQEndothelin-18HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
4.35Single8HK5Complement C58HK5-C5a1-Complement C5-Gi1/&β;1/&γ;2
4.35Consensusc5a1_onOrthosteric Ligand7Y65-C5a1-C5a peptide-Gi1/&β;1/&γ;2 8HK5-C5a1-Complement C5-Gi1/&β;1/&γ;2 7Y66-C5a1-BM213-Gi1/&β;1/&γ;2 7Y67-C5a1-C089 peptide-Gi1/&β;1/&γ;2 7Y64-C5a1-C5a anaphylatoxin-Gi1/&β;1/&γ;2
4.35Consensuscrf2_onOrthosteric Ligand7TS0-CRF2-Urocortin-chim(NtGi1L-Go)/&β;1/&γ;2
4.35Consensuseta_onOrthosteric Ligand8HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
4.35Consensusgq_class-aOrthosteric Ligandgq_amine gq_peptide
4.35Consensusgs_ghrelinOrthosteric Ligand7F9Y-Ghrelin-Ghrelin-28-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
4.35Consensusvpac1_onOrthosteric Ligand8E3Y-VPAC1-PACAP27-Gs/&β;1/&γ;2 8E3Z-VPAC1-VIP-Gs/&β;1/&γ;2 6VN7-VPAC1-PACAP-Gs/&β;1/&γ;2
4.17Single5UIW5P7-CCL55UIW-CCR5-5P7-CCL5
4.17Single6FJ3PTH6FJ3-PTH1-PTH
4.17Single6NBFLong-acting PTH analog6NBF-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2
4.17Single6NBILong-acting PTH analog6NBI-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2
4.17Single7FIYTirzepatide7FIY-GIP-Tirzepatide-Gs/&β;1/&γ;2
4.17Single7KI0Semaglutide7KI0-GLP-1-Semaglutide-Gs/&β;1/&γ;2
4.17Single7RA3GIP7RA3-GIP-GIP-chim(NtGi1-Gs)/&β;1/&γ;2
4.17Single7RGPTirzepatide7RGP-GLP-1-Tirzepatide-chim(NtGi1-Gs)/&β;1/&γ;2
4.17Single7SK3CXCL127SK3-ACKR3-CXCL12
4.17Single7SK4CXCL12_LRHQ7SK4-ACKR3-CXCL12_LRHQ
4.17Single7VABNon-Acylated Tirzepatide7VAB-GIP-Non-Acylated Tirzepatide-chim(NtGi1-Gs)/&β;1/&γ;2
4.17Single8E3XPACAP278E3X-PAC1-PACAP27-Gs/&β;1/&γ;2
4.17Single8FLRPTHrP(1-36)8FLR-PTH1-PTHrP(1-36)-Gs/&β;1/&γ;2
4.17Single8HAOPTH8HAO-PTH1-PTH-chim(NtGi1-Gs)/&β;1/&γ;2
4.17Single8JISPeptide-158JIS-GLP-1-Peptide-15-chim(NtGi1-Gs)/&β;1/&γ;2
4.17Consensusbradykinin_onOrthosteric Ligandbk2_on bk1_on
4.17Consensusccr5_offOrthosteric Ligand5UIW-CCR5-5P7-CCL5
4.17Consensusccr5_onOrthosteric Ligand7O7F-CCR5-(6P4)CCL5-Gi1/&β;1/&γ;1 7F1Q-CCR5-MIP-1a-Gi1/&β;1/&γ;2
4.17Consensusctlike_onOrthosteric Ligand6E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/&β;1/&γ;2; RAMP1 6UUN-CT Like (AM1)-Adrenomedullin-Gs/&β;1/&γ;2; RAMP2
4.17Consensusgi_compl-peptideOrthosteric Ligand8HK5-C5a1-Complement C5-Gi1/&β;1/&γ;2 8IA8-C3aB-E7 peptide-Gi1/&β;1/&γ;2 7Y66-C5a1-BM213-Gi1/&β;1/&γ;2 7Y67-C5a1-C089 peptide-Gi1/&β;1/&γ;2 8HK2-C3aB-C3a anaphylatoxin-Gi1/&β;1/&γ;2 7Y64-C5a1-C5a anaphylatoxin-Gi1/&β;1/&γ;2 7Y65-C5a1-C5a peptide-Gi1/&β;1/&γ;2
4.17Consensusglp1_on_alloOrthosteric Ligand6VCB-GLP-1-GLP-1-LSN3160440-Gs/&β;1/&γ;2
4.17Consensusgs_vasopressin-otOrthosteric Ligand7RYC-OT-Oxytocin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 7DW9-V2-Acyclovir triphosphate-chim(NtGi1-Gs)/&β;1/&γ;2
4.17Consensusnpy2_onOrthosteric Ligand7YOO-Y2-Neuropeptide Y-Gi1/&β;1/&γ;2 7YON-Y2-Peptide YY(3-36)-Gi1/&β;1/&γ;2
4.00Single5NX2GLP-1 (Truncated)5NX2-GLP-1-GLP-1 (Truncated)
4.00Single6LMKGlucagon6LMK-Glucagon-Glucagon-Gs/&β;1/&γ;2
4.00Single6UVAAdrenomedullin-26UVA-CT Like (AM2)-Adrenomedullin-2-Gs/&β;1/&γ;2; RAMP3
4.00Single6VCBGLP-16VCB-GLP-1-GLP-1-LSN3160440-Gs/&β;1/&γ;2
4.00Single7DTYGIP7DTY-GIP-GIP-Gs/&β;1/&γ;2
4.00Single7F53Alpha-MSH7F53-MC4-Alpha-MSH-Gs/&β;1/&γ;2
4.00Single7S1MEx4-D-Ala7S1M-GLP-1-Ex4-D-Ala-Gs/&β;1/&γ;2
4.00Single7VQXPACAP277VQX-VPAC1-PACAP27-Gs/&β;1/&γ;2
4.00Single7VVJPTHrP(1-36)7VVJ-PTH1-PTHrP(1-36)-Gs/&β;1/&γ;2
4.00Single7YOONeuropeptide Y7YOO-Y2-Neuropeptide Y-Gi1/&β;1/&γ;2
4.00Single8FU6Glucagon derivative ZP37808FU6-Glucagon-Glucagon derivative ZP3780-Gs/&β;1/&γ;2
4.00Consensusccr8_onOrthosteric Ligand8U1U-CCR8-CCL1-Gi1/&β;1/&γ;2
4.00Consensusccr_onOrthosteric Ligandccr5_on ccr6_on ccr1_on ccr2_on ccr8_on
4.00Consensusgi_proteinOrthosteric Ligandgi_chemokine gi_chemerin
4.00Consensusglp2_onOrthosteric Ligand7D68-GLP-2-GLP-2-Gs/&β;1/&γ;2
4.00Consensusgo_class-b1Orthosteric Ligandgo_crf
4.00Consensusgo_crfOrthosteric Ligand7TS0-CRF2-Urocortin-chim(NtGi1L-Go)/&β;1/&γ;2
4.00Consensusgs_cgrpOrthosteric Ligand6E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/&β;1/&γ;2; RAMP1 6UUN-CT Like (AM1)-Adrenomedullin-Gs/&β;1/&γ;2; RAMP2
3.85Single6B3JExendin-P56B3J-GLP-1-Exendin-P5-Gs/&β;1/&γ;2
3.85Single6LMLGlucagon6LML-Glucagon-Glucagon
3.85Single6NBHLong-acting PTH analog6NBH-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2
3.85Single6UUSAdrenomedullin6UUS-CT Like (AM2)-Adrenomedullin-Gs/&β;1/&γ;2; RAMP3
3.85Single6WZGSecretin6WZG-Secretin-Secretin-Gs/&β;1/&γ;2
3.85Single7D68GLP-27D68-GLP-2-GLP-2-Gs/&β;1/&γ;2
3.85Single7KI1Taspoglutide7KI1-GLP-1-Taspoglutide-Gs/&β;1/&γ;2
3.85Single7TYWCalcitonin-17TYW-CT (AMY1)-Calcitonin-1-Gs/&β;1/&γ;2; RAMP1
3.85Single7VVKPTH7VVK-PTH1-PTH-Gs/&β;1/&γ;2
3.85Single7VVLPTH7VVL-PTH1-PTH-Gs/&β;1/&γ;2
3.85Single8HAFPTHrP(1-36)8HAF-PTH1-PTHrP(1-36)-chim(NtGi1-Gs)/&β;1/&γ;2
3.85Single8IY5Endothelin-18IY5-ETB-Endothelin-1-Gi1/&β;1/&γ;2
3.85Single8IY6Endothelin-18IY6-ETB-Endothelin-1
3.85Consensuscalcitonin_onOrthosteric Ligandct_on ctlike_on
3.85Consensuscrf_onOrthosteric Ligandcrf2_on crf1_on
3.85Consensusgi_chemokineOrthosteric Ligand7VL9-CCR1-CCL15(26-92)-Gi1/&β;1/&γ;2 7XA3-CCR2-CCL2-Gi1/&β;1/&γ;2 7O7F-CCR5-(6P4)CCL5-Gi1/&β;1/&γ;1 7F1Q-CCR5-MIP-1a-Gi1/&β;1/&γ;2 7XBX-CX3CR1-CX3CL1-Gi1/&β;1/&γ;2 8IC0-CXCR1-Interleukin-8-Gi1/&β;1/&γ;2 6LFM-CXCR2-Interleukin-8-Gi1/&β;1/&γ;2 8U1U-CCR8-CCL1-Gi1/&β;1/&γ;2
3.85Consensusglp1_onOrthosteric Ligand6X18-GLP-1-GLP-1-Gs/&β;1/&γ;2 6X19-GLP-1-CHU-128-Gs/&β;1/&γ;2 6X1A-GLP-1-Danuglipron-Gs/&β;1/&γ;2 7S1M-GLP-1-Ex4-D-Ala-Gs/&β;1/&γ;2 7LLL-GLP-1-Exendin-4-Gs/&β;1/&γ;2 6B3J-GLP-1-Exendin-P5-Gs/&β;1/&γ;2 8JIP-GLP-1-MEDI0382-chim(NtGi1-Gs)/&β;1/&γ;2 7VBI-GLP-1-Non-Acylated Tirzepatide-Gs/&β;1/&γ;2 6XOX-GLP-1-Orforglipron-chim(NtGi1-Gs)/&β;1/&γ;2 8JIS-GLP-1-Peptide-15-chim(NtGi1-Gs)/&β;1/&γ;2 7RTB-GLP-1-Peptide-19-Gs/&β;1/&γ;2 7VBH-GLP-1-Peptide-20-Gs/&β;1/&γ;2 7C2E-GLP-1-PubChem 149050799-Gs/&β;1/&γ;2 8JIR-GLP-1-SAR425899-chim(NtGi1-Gs)/&β;1/&γ;2 7KI0-GLP-1-Semaglutide-Gs/&β;1/&γ;2 7KI1-GLP-1-Taspoglutide-Gs/&β;1/&γ;2 7FIM-GLP-1-Tirzepatide-Gs/&β;1/&γ;2
3.85Consensusgq_bradykininOrthosteric Ligand7F6H-BK2-Bradykinin-Gq/&β;1/&γ;2 7F6I-BK2-Kallidin-Gq/&β;1/&γ;2
3.85Consensusgq_peptideOrthosteric Ligandgq_cck gq_angiotensin gq_bombesin gq_bradykinin
3.85Consensusgs_peptideOrthosteric Ligandgs_cck gs_motilin gs_neuromedin gs_orexin gs_sst gs_tachykinin gs_trh gs_vasopressin-ot gs_bombesin gs_bradykinin gs_compl-peptide gs_endothelin gs_galanin gs_ghrelin gs_melanocortin
3.85Consensuspeptide_onOrthosteric Ligandopioid_on angiotensin_on bombesin_on cck_on endothelin_on ghrelin_on npy_on nts_on orexin_on vasopressin-ot_on tachykinin_on sst_on relaxin_on trh_on nmur_on motilin_on melanocortin_on galanin_on fpr-alx_on compl-peptide_on bradykinin_on apelin_on
3.85Consensussecretin_onOrthosteric Ligand6WZG-Secretin-Secretin-Gs/&β;1/&γ;2
3.85Consensusvpac2_onOrthosteric Ligand7VQX-VPAC1-PACAP27-Gs/&β;1/&γ;2
3.70Single5GLHEndothelin-15GLH-ETB-Endothelin-1
3.70Single5VAIGLP-15VAI-GLP-1-GLP-1-Gs/&β;1/&γ;2
3.70Single6IGKEndothelin-36IGK-ETB-Endothelin-3
3.70Single7DUQGLP-17DUQ-GLP-1-GLP-1-PubChem 156022738-Gs/&β;1/&γ;2
3.70Single7RBTTirzepatide7RBT-GIP-Tirzepatide-PubChem 163183774-chim(NtGi1-Gs)/&β;1/&γ;2
3.70Single7TS0Urocortin7TS0-CRF2-Urocortin-chim(NtGi1L-Go)/&β;1/&γ;2
3.70Single7TYFAmylin7TYF-CT (AMY1)-Amylin-Gs/&β;1/&γ;2; RAMP1
3.70Single7TYIAmylin7TYI-CT-Amylin-Gs/&β;1/&γ;2
3.70Single7TYLAmylin7TYL-CT-Amylin-Gs/&β;1/&γ;2
3.70Single7TYNCalcitonin-17TYN-CT-Calcitonin-1-Gs/&β;1/&γ;2
3.70Single7TYXAmylin7TYX-CT (AMY2)-Amylin-Gs/&β;1/&γ;2; RAMP2
3.70Consensusgi_peptideOrthosteric Ligandgi_opioid gi_endothelin gi_formylpeptide gi_galanin gi_ghrelin gi_neuromedin gi_neurotensin gi_relaxin gi_neuropeptide gi_somatostatin gi_apelin gi_compl-peptide gi_cck
3.70Consensusgip_onOrthosteric Ligand7DTY-GIP-GIP-Gs/&β;1/&γ;2 7VAB-GIP-Non-Acylated Tirzepatide-chim(NtGi1-Gs)/&β;1/&γ;2 7FIN-GIP-Peptide-20; GGL-Gs/&β;1/&γ;2 7FIY-GIP-Tirzepatide-Gs/&β;1/&γ;2
3.70Consensusgip_on_alloOrthosteric Ligand7RBT-GIP-Tirzepatide-PubChem 163183774-chim(NtGi1-Gs)/&β;1/&γ;2
3.57Single6LPBPACAP6LPB-PAC1-PACAP-Gs/&β;1/&γ;1
3.57Single6WPWGlucagon derivative ZP37806WPW-Glucagon-Glucagon derivative ZP3780-Gs/&β;1/&γ;2
3.57Single7SK6CXCL12_LRHQ7SK6-ACKR3-CXCL12_LRHQ
3.57Single7TYHCalcitonin-17TYH-CT (AMY2)-Calcitonin-1-Gs/&β;1/&γ;2; RAMP2
3.57Single7VBHPeptide-207VBH-GLP-1-Peptide-20-Gs/&β;1/&γ;2
3.57Single8FLSAbaloparatide8FLS-PTH1-Abaloparatide-Gs/&β;1/&γ;2
3.57Single8FLULong-acting PTH8FLU-PTH1-Long-acting PTH-Gs/&β;1/&γ;2
3.57Consensusglp_onOrthosteric Ligandglp1_on glp2_on
3.57Consensusmelanocortin_onOrthosteric Ligandmc2_on mc1_on mc3_on mc4_on mc5_on
3.45Single6LRYSarafotoxin-B6LRY-ETB-Sarafotoxin-B
3.45Single7TZFAmylin7TZF-CT (AMY3)-Amylin-Gs/&β;1/&γ;2; RAMP3
3.45Single7V35Peptide-207V35-Glucagon-Peptide-20-Gs/&β;1/&γ;2
3.45Single7VVMPTH7VVM-PTH1-PTH-Gs/&β;1/&γ;2
3.45Single8F0KPramlintide analogue san3858F0K-CT (AMY3)-Pramlintide analogue san385-Gs/&β;1/&γ;2; RAMP3
3.45Single8JIPMEDI03828JIP-GLP-1-MEDI0382-chim(NtGi1-Gs)/&β;1/&γ;2
3.45Single8JIRSAR4258998JIR-GLP-1-SAR425899-chim(NtGi1-Gs)/&β;1/&γ;2
3.45Single8U1UCCL18U1U-CCR8-CCL1-Gi1/&β;1/&γ;2
3.45Consensuspth1_onOrthosteric Ligand8FLQ-PTH1-PTH-Gs/&β;1/&γ;2 8FLR-PTH1-PTHrP(1-36)-Gs/&β;1/&γ;2 7Y36-PTH1-Teriparatide-Gs/&β;1/&γ;2 7Y35-PTH1-Abaloparatide-Gs/&β;1/&γ;2 8FLU-PTH1-Long-acting PTH-Gs/&β;1/&γ;2 6NBF-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2 7VVM-PTH1-PTH-Gs/&β;1/&γ;2
3.45Consensusvip-pacap_onOrthosteric Ligandvpac1_on vpac2_on pca1_on
3.33Single7TYYCalcitonin-17TYY-CT (AMY2)-Calcitonin-1-Gs/&β;1/&γ;2; RAMP2
3.33Single7X9ANeuropeptide Y7X9A-Y1-Neuropeptide Y-Gi1/&β;1/&γ;2
3.33Single7Y36Teriparatide7Y36-PTH1-Teriparatide-Gs/&β;1/&γ;2
3.33Single8FLQPTH8FLQ-PTH1-PTH-Gs/&β;1/&γ;2
3.33Single8JITMEDI03828JIT-Glucagon-MEDI0382-Gs/&β;1/&γ;2
3.33Consensusgi_neuropeptideOrthosteric Ligand7YOO-Y2-Neuropeptide Y-Gi1/&β;1/&γ;2 7YON-Y2-Peptide YY(3-36)-Gi1/&β;1/&γ;2 7X9C-Y4-Pancreatic Hormone-Gi1/&β;1/&γ;2 7X9A-Y1-Neuropeptide Y-Gi1/&β;1/&γ;2
3.33Consensusgs_glucagonOrthosteric Ligand6X18-GLP-1-GLP-1-Gs/&β;1/&γ;2 6B3J-GLP-1-Exendin-P5-Gs/&β;1/&γ;2 6WZG-Secretin-Secretin-Gs/&β;1/&γ;2 6X1A-GLP-1-Danuglipron-Gs/&β;1/&γ;2 7CZ5-GHRH-Somatoliberin-Gs/&β;1/&γ;2 7D68-GLP-2-GLP-2-Gs/&β;1/&γ;2 7DTY-GIP-GIP-Gs/&β;1/&γ;2 7FIM-GLP-1-Tirzepatide-Gs/&β;1/&γ;2 7FIN-GIP-Peptide-20; GGL-Gs/&β;1/&γ;2 7FIY-GIP-Tirzepatide-Gs/&β;1/&γ;2 7KI0-GLP-1-Semaglutide-Gs/&β;1/&γ;2 7RTB-GLP-1-Peptide-19-Gs/&β;1/&γ;2 7S1M-GLP-1-Ex4-D-Ala-Gs/&β;1/&γ;2 7VAB-GIP-Non-Acylated Tirzepatide-chim(NtGi1-Gs)/&β;1/&γ;2 8JIU-Glucagon-SAR425899-Gs/&β;1/&γ;2
3.33Consensusgs_vip-pacapOrthosteric Ligand8E3Y-VPAC1-PACAP27-Gs/&β;1/&γ;2 7VQX-VPAC1-PACAP27-Gs/&β;1/&γ;2 8E3Z-VPAC1-VIP-Gs/&β;1/&γ;2 6M1I-PAC1-PACAP-Gs/&β;1/&γ;2 6VN7-VPAC1-PACAP-Gs/&β;1/&γ;2
3.33Consensusmc2_onOrthosteric Ligand8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/&β;1/&γ;2; MRAP1
3.33Consensusnpy1_onOrthosteric Ligand7X9A-Y1-Neuropeptide Y-Gi1/&β;1/&γ;2
3.33Consensusnpy_onOrthosteric Ligandnpy2_on npy4_on npy1_on
3.33Consensuspth2_onOrthosteric Ligand7F16-PTH2-TIP39-Gs/&β;1/&γ;2
3.23Single6E3YCalcitonin gene-related peptide-16E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/&β;1/&γ;2; RAMP1
3.23Single8JIUSAR4258998JIU-Glucagon-SAR425899-Gs/&β;1/&γ;2
3.23Consensusgs_class-bOrthosteric Ligandgs_class-b1 gs_class-b2
3.23Consensuspth_onOrthosteric Ligandpth1_on pth2_on
3.12Single8F2APramlintide analogue san3858F2A-CT (AMY3)-Pramlintide analogue san385-Gs/&β;1/&γ;2; RAMP3
3.12Consensusct_onOrthosteric Ligand7TYL-CT-Amylin-Gs/&β;1/&γ;2 7TYN-CT-Calcitonin-1-Gs/&β;1/&γ;2 8F0J-CT-Pramlintide analogue san45-Gs/&β;1/&γ;2 6NIY-CT-Adrenomedullin-Gs/&β;1/&γ;2
3.03Single7F16TIP397F16-PTH2-TIP39-Gs/&β;1/&γ;2
3.03Consensusglucagon_onOrthosteric Ligandgip_on glu_on secretin_on ghrh_on glp_on
3.03Consensusgs_pthOrthosteric Ligand8FLQ-PTH1-PTH-Gs/&β;1/&γ;2 7Y35-PTH1-Abaloparatide-Gs/&β;1/&γ;2 7Y36-PTH1-Teriparatide-Gs/&β;1/&γ;2 7F16-PTH2-TIP39-Gs/&β;1/&γ;2 7VVM-PTH1-PTH-Gs/&β;1/&γ;2 8FLU-PTH1-Long-acting PTH-Gs/&β;1/&γ;2 6NBF-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2
2.94Single7TYOCalcitonin7TYO-CT-Calcitonin-Gs/&β;1/&γ;2
2.94Consensusclass-b1_onOrthosteric Ligandglucagon_on calcitonin_on vip-pacap_on pth_on crf_on
2.94Consensusglu_onOrthosteric Ligand6LMK-Glucagon-Glucagon-Gs/&β;1/&γ;2 6WPW-Glucagon-Glucagon derivative ZP3780-Gs/&β;1/&γ;2 8JIT-Glucagon-MEDI0382-Gs/&β;1/&γ;2 8JIQ-Glucagon-Peptide-15-Gs/&β;1/&γ;2 7V35-Glucagon-Peptide-20-Gs/&β;1/&γ;2 8JIU-Glucagon-SAR425899-Gs/&β;1/&γ;2 6WHC-Glucagon-Glu16 analog of GCG-Gs/&β;1/&γ;2
2.86Single8F2BPramlintide analogue san458F2B-CT (AMY3)-Pramlintide analogue san45-Gs/&β;1/&γ;2; RAMP3
2.86Consensusgs_calcitoninOrthosteric Ligandgs_ct gs_cgrp
2.86Consensusgs_ctOrthosteric Ligand7TYN-CT-Calcitonin-1-Gs/&β;1/&γ;2 6NIY-CT-Adrenomedullin-Gs/&β;1/&γ;2 8F0J-CT-Pramlintide analogue san45-Gs/&β;1/&γ;2 7TYL-CT-Amylin-Gs/&β;1/&γ;2 8F0K-CT (AMY3)-Pramlintide analogue san385-Gs/&β;1/&γ;2; RAMP3
2.78Single8GY7Corticotropin8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/&β;1/&γ;2; MRAP1
2.78Consensusgs_class-b1Orthosteric Ligandgs_glucagon gs_vip-pacap gs_pth gs_calcitonin gs_crf
2.70Single8F0JPramlintide analogue san458F0J-CT-Pramlintide analogue san45-Gs/&β;1/&γ;2

PDB Summary
PDB 7T9M
Class A
SubFamily Protein
Type Glycoprotein hormone
SubType TSH
Species Homo sapiens
Ligand -
Other Ligand(s) CS-17 Antibody
Protein Partners -
PDB Resolution 3.1
Date 2022-08-10
D.O.I. 10.1038/s41586-022-05159-1
Net Summary
Imin 2.64
Number of Linked Nodes 956
Number of Links 1194
Number of Hubs 206
Number of Links mediated by Hubs 714
Number of Communities 31
Number of Nodes involved in Communities 305
Number of Links involved in Communities 447
Path Summary
Number Of Nodes in MetaPath 107
Number Of Links MetaPath 106
Number of Shortest Paths 4917592
Length Of Smallest Path 3
Average Path Length 33.0729
Length of Longest Path 63
Minimum Path Strength 1.43
Average Path Strength 5.91505
Maximum Path Strength 31.525
Minimum Path Correlation 0.74
Average Path Correlation 0.996763
Maximum Path Correlation 1
Minimum % Of Corr. Nodes 4
Average % Of Corr. Nodes 47.4667
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 54.7833
Maximum Path Hubs % 100

Details about the values in these tables can be found in the corresponding documentation page .
CodeNAG
PDB ResiduesH:H:?1 H:H:?2 H:H:?3 H:H:?4 H:H:?5
Environment DetailsOpen EMBL-EBI Page
CodeNAG
NameN-Acetylglucosamine
SynonymsN-Acetyl-D-glucosamine
IdentifierN-[(2R,3R,4R,5S,6R)-6-(hydroxymethyl)-2,4,5-tris(oxidanyl)oxan-3-yl]ethanamide
FormulaC8 H15 N O6
Molecular Weight221.208
SMILESCC(=O)N[C@@H]1[C@H]([C@@H]([C@H](O[C@H]1O)CO)O)O
PubChem24139
Formal Charge0
Total Atoms30
Total Chiral Atoms5
Total Bonds30
Total Aromatic Bonds0



This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
7T9IAProteinGlycoprotein hormoneTSHHomo sapiensTSH-Gs/&β;1/&γ;22.92022-08-0310.1038/s41586-022-05159-1
7T9MAProteinGlycoprotein hormoneTSHHomo sapiens-CS-17 Antibody-3.12022-08-1010.1038/s41586-022-05159-1
7T9NAProteinGlycoprotein hormoneTSHHomo sapiensM22 FabPubChem 644078Gs/&β;1/&γ;22.92022-08-0310.1038/s41586-022-05159-1
7UTZAProteinGlycoprotein hormoneTSHHomo sapiensTR1402PubChem 644078Gs/&β;1/&γ;22.42022-08-0310.1038/s41586-022-05159-1
7XW5AProteinGlycoprotein hormoneTSHHomo sapiensTSHML109Gs/&β;1/&γ;22.962022-08-2410.1038/s41586-022-05173-3
7XW6AProteinGlycoprotein hormoneTSHHomo sapiensM22 FabML109Gs/&β;1/&γ;22.782022-08-1710.1038/s41586-022-05173-3
7XW7AProteinGlycoprotein hormoneTSHHomo sapiensK1-70--5.52022-08-1710.1038/s41586-022-05173-3




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