Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg Int. Strength Num Of Links Community ConSurf
1A:A:Y37 9.7575454
2A:A:S51 3.33254269
3A:A:K53 5.506676269
4A:A:G206 3.535418
5A:A:V214 6.335466
6A:A:F219 6.732568
7A:A:F222 12.0125417
8A:A:Q227 4.53667619
9A:A:K233 6.315619
10A:A:W234 6.14833619
11A:A:C237 6.7725418
12A:A:F238 9.308519
13A:A:F246 5.03409
14A:A:S250 3.73254116
15A:A:F273 5.436179
16A:A:W277 9.122867176
17A:A:W281 13.25615
18A:A:I288 6.0275409
19A:A:L289 5.11509
20A:A:F290 5.38754209
21A:A:Q294 9.1854116
22A:A:I308 5.79754147
23A:A:F312 5.484297148
24A:A:E314 4.7565146
25A:A:F315 8.26146
26A:A:Y318 8.9045146
27A:A:E330 10.154113
28A:A:K338 10.3265115
29A:A:Y339 7.6845113
30A:A:F340 10.5756147
31A:A:R342 6.8145114
32A:A:E344 7.75145
33A:A:F345 9.2875408
34A:A:S349 4.1725407
35A:A:R356 8.855402
36A:A:Y358 6.9025464
37A:A:Y360 10.345408
38A:A:F363 11.0845115
39A:A:T364 6.684209
40A:A:N371 9.03254209
41A:A:R373 5.468565
42A:A:F376 6.81833668
43A:A:I383 4.6925468
44A:A:Q384 6.6725466
45A:A:R385 8.426565
46A:A:Y391 7.855404
47B:B:I18 3.99487
48B:B:R22 7.415486
49B:B:I37 6.74122
50B:B:V40 4.843336123
51B:B:H54 8.57833659
52B:B:K57 11.39519
53B:B:Y59 8.516518
54B:B:M61 4.8875456
55B:B:W63 6.85667657
56B:B:V71 4.6654138
57B:B:Q75 10.9375419
58B:B:D76 7.068559
59B:B:K78 5.3125408
60B:B:L79 74137
61B:B:I81 5.63754137
62B:B:W82 10.0586759
63B:B:D83 10.8875458
64B:B:T86 8.3225456
65B:B:N88 11.13457
66B:B:K89 5.69659
67B:B:I93 5.32407
68B:B:L95 5.84754138
69B:B:W99 9.20333619
70B:B:M101 6.4175419
71B:B:Y105 5.151258136
72B:B:N110 6.1554184
73B:B:Y111 7.864184
74B:B:L117 4.852519
75B:B:I120 5.8406
76B:B:I123 3.826676186
77B:B:Y124 6.245136
78B:B:L126 4.1945135
79B:B:H142 8.05833619
80B:B:Y145 6.97857718
81B:B:F151 6.314509
82B:B:I157 6.0375407
83B:B:V158 4.6175475
84B:B:T159 6.0875419
85B:B:S160 4.42476
86B:B:D163 9.12419
87B:B:W169 9.705618
88B:B:Q176 8.665414
89B:B:F180 8.588577
90B:B:H183 8.60333679
91B:B:D186 6.84419
92B:B:F199 10.7775479
93B:B:S201 5.2625479
94B:B:C204 4.965617
95B:B:D205 7.015479
96B:B:K209 9.832576
97B:B:W211 9.14167678
98B:B:R214 7.845409
99B:B:Q220 7.02487
100B:B:F222 8.8575488
101B:B:H225 9.12857789
102B:B:D228 8.718519
103B:B:I232 5.86488
104B:B:F234 5.0975405
105B:B:F235 7.943336216
106B:B:P236 6.37754217
107B:B:F241 8.634586
108B:B:T243 5.8975488
109B:B:D246 7.55419
110B:B:D247 7.842589
111B:B:T249 7.495486
112B:B:R251 11.265688
113B:B:F253 7.315686
114B:B:D254 5.048509
115B:B:R256 8.7975409
116B:B:D258 10.2625487
117B:B:Q259 4.746506
118B:B:E260 7.35486
119B:B:M262 6.5475404
120B:B:T263 6.2975481
121B:B:Y264 7.726505
122B:B:I269 4.672514
123B:B:F278 7.694217
124B:B:R283 8.0956129
125B:B:L284 4.9745125
126B:B:L285 4.79406
127B:B:Y289 7.74714717
128B:B:D290 7.116516
129B:B:N295 6.876516
130B:B:V296 3.81254125
131B:B:W297 6.6625418
132B:B:L300 6.8654126
133B:B:R304 5.136515
134B:B:H311 10.666599
135B:B:R314 15.412518
136B:B:M325 4.966505
137B:B:W332 11.28719
138B:B:D333 9.115499
139B:B:L336 5.038557
140B:B:K337 8.13167696
141B:B:W339 11.224599
142B:B:N340 5.58754159
143E:E:R37 4.86571744
144E:E:L41 4.582507
145E:E:F44 7.368549
146E:E:I63 5.424304
147E:E:Y66 6.51833649
148E:E:L69 10.86448
149E:E:T73 4.995449
150E:E:W84 5.868509
151E:E:F92 6.664548
152E:E:F93 7.88449
153E:E:H97 8.555449
154E:E:Y100 14.782549
155E:E:F101 6.845449
156E:E:D113 5.6665109
157E:E:P114 6.99254109
158E:E:I118 3.4565106
159E:E:T130 4.76254169
160G:G:L19 4.5225409
161G:G:R27 6.834588
162G:G:Y40 10.394216
163G:G:D48 6.364509
164G:G:L51 4.0725126
165G:G:N59 6.774159
166G:G:P60 7.524159
167G:G:F61 5.556258158
168L:L:T6 5.25833620
169L:L:L16 4.866220
170L:L:L23 7.52254220
171L:L:T30 4.188530
172L:L:T36 3.775400
173L:L:Y37 8.405400
174L:L:?38 7.7675430
175R:R:Y53 6.338541
176R:R:Y56 6.87333643
177R:R:L62 6.69754243
178R:R:Y65 11.8625403
179R:R:W76 7.554548
180R:R:D77 5.618539
181R:R:W79 9.82714736
182R:R:L80 5.914535
183R:R:W82 7.59833639
184R:R:C95 5.015439
185R:R:Y98 8.838534
186R:R:F99 9.595435
187R:R:D101 5.0175404
188R:R:F102 7.14286734
189R:R:E106 5.4275434
190R:R:V108 6.0475437
191R:R:K110 13.2438
192R:R:D113 3.9725405
193R:R:W118 14.3975439
194R:R:H121 7.554534
195R:R:W128 8.38435
196R:R:S129 6.022537
197R:R:Y131 8.95143735
198R:R:M133 5.514535
199R:R:N135 6.12403
200R:R:Y149 6.87754225
201R:R:H156 9.1225407
202R:R:S166 5.2175409
203R:R:F170 7.2375408
204R:R:F173 5.08833697
205R:R:L176 5.646599
206R:R:Q179 7.3325427
207R:R:R180 6.111676289
208R:R:F188 5.076508
209R:R:T190 5.37429
210R:R:Y191 9.67628
211R:R:V205 5.085407
212R:R:L211 5.77754191
213R:R:C219 4.414199
214R:R:F224 2.5225405
215R:R:Y234 8.75627
216R:R:F235 4.925165
217R:R:W236 8.73729
218R:R:M237 4.8075429
219R:R:L238 5.248508
220R:R:I242 4.994507
221R:R:Y243 7.755628
222R:R:H245 14.245468
223R:R:I248 4.68567
224R:R:F253 8.302566
225R:R:Q257 7.908525
226R:R:W261 9.1254232
227R:R:Y262 6.15143727
228R:R:L265 4.87754167
229R:R:W267 7.8925429
230R:R:F269 6.17163
231R:R:P270 4.3925169
232R:R:H277 8.6625107
233R:R:R281 8.271676107
234R:R:F285 9.486676106
235R:R:W290 12.015109
236R:R:L291 3.77254196
237R:R:V293 3.974316
238R:R:T295 10.8154104
239R:R:L297 5.4185104
240R:R:H302 7.028526
241R:R:P304 4.5854169
242R:R:K326 7.192569
243R:R:Q355 7.4525428
244R:R:F356 6.33125827
245R:R:R362 8.5925404
246R:R:Y372 8.07754367
247R:R:Y374 7.8254346
248R:R:H377 7.3407
249R:R:H381 7.142509
250R:R:Q383 8.7925429
251R:R:F385 9.1325405
252R:R:Y391 8.54358
253R:R:F393 5.1825408
254R:R:F409 4.98493
255H:H:?2 11.48530
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
1R:R:L176 R:R:T401 55.655710.32YesNo997
2R:R:F173 R:R:T401 55.70433.89YesNo977
3R:R:F173 R:R:Q405 1003.51YesNo974
4B:B:D312 R:R:Q405 1003.92NoNo954
5B:B:D312 B:B:D333 1005.32NoYes959
6B:B:D333 B:B:H311 10010.08YesYes999
7B:B:H311 B:B:T329 75.26538.21YesNo998
8B:B:T329 B:B:W339 75.250110.92NoYes989
9B:B:M45 B:B:W339 1003.49NoYes949
10B:B:M45 G:G:L50 1005.65NoNo049
11B:B:V327 G:G:L50 1004.47NoNo069
12B:B:L286 B:B:V327 1004.47NoNo076
13B:B:L286 B:B:V296 1002.98NoYes075
14B:B:L284 B:B:V296 1005.96YesYes1255
15B:B:L284 B:B:S279 73.88536.01YesNo059
16B:B:S279 G:G:D48 73.83228.83NoYes099
17G:G:D48 G:G:P49 1003.22YesNo097
18B:B:M325 G:G:P49 1006.71YesNo057
19B:B:M325 G:G:P60 69.06436.71YesYes059
20B:B:Y85 G:G:P60 68.11212.52NoYes1549
21B:B:R68 B:B:Y85 68.052231.9NoNo054
22B:B:D83 B:B:R68 34.450719.06YesNo085
23B:B:H311 B:B:K337 75.355518.34YesYes996
24B:B:K337 B:B:W339 75.339610.44YesYes969
25B:B:L284 G:G:L51 74.54814.15YesYes1256
26G:G:D48 G:G:L51 73.99296.79YesYes096
27B:B:S316 B:B:W332 71.4733.71NoYes099
28A:A:W281 B:B:W332 40.71759.37YesYes159
29A:A:N279 A:A:W281 13.89295.65NoYes085
30A:A:L282 A:A:N279 13.76979.61NoNo098
31A:A:I276 A:A:L282 13.40424.28NoNo089
32A:A:I276 A:A:L272 13.28364.28NoNo088
33A:A:F246 A:A:L272 13.33116.09YesNo098
34B:B:D83 B:B:L69 33.40264.07YesNo085
35B:B:L69 B:B:Y105 66.50415.86NoYes056
36B:B:V71 B:B:Y105 10.18086.31YesYes1386
37B:B:L126 B:B:Y105 54.22283.52YesYes1356
38B:B:R314 B:B:W332 19.073219.99YesYes189
39A:A:F345 A:A:L270 10.326812.18YesNo086
40A:A:W281 B:B:D290 18.48838.93YesYes156
41B:B:D290 B:B:R314 18.464313.1YesYes168
42B:B:C271 B:B:D290 36.54494.67NoYes156
43B:B:C271 B:B:Y289 35.55874.03NoYes157
44B:B:W297 B:B:Y289 30.38315.79YesYes187
45B:B:W297 B:B:Y264 29.653114.47YesYes085
46B:B:L285 B:B:Y264 26.21454.69YesYes065
47B:B:F278 B:B:L285 25.47849.74YesYes076
48B:B:F235 B:B:F278 23.75810.72YesYes2167
49B:B:F235 G:G:L37 21.06017.31YesNo067
50B:B:D254 G:G:L37 20.56994.07YesNo097
51B:B:A257 B:B:D254 18.36454.63NoYes079
52B:B:A257 B:B:Q259 18.11983.03NoYes076
53B:B:Q259 B:B:R22 17.39315.84YesYes066
54B:B:C317 B:B:M61 71.45074.86NoYes076
55B:B:T321 B:B:W63 76.07512.13NoYes577
56B:B:D66 B:B:R68 33.48324.76NoNo085
57B:B:D66 B:B:L69 33.36219.5NoNo085
58B:B:D323 B:B:M325 76.42674.16NoYes075
59B:B:K127 B:B:L126 50.97454.23NoYes045
60B:B:K127 B:B:N110 50.73585.6NoYes044
61B:B:N110 B:B:Y111 50.01833.49YesYes1844
62B:B:I123 B:B:Y111 48.37423.63YesYes1864
63B:B:I123 B:B:L139 16.32514.28YesNo069
64B:B:C121 B:B:L139 14.82264.76NoNo089
65B:B:C121 B:B:C149 14.46353.64NoNo088
66B:B:C149 B:B:T102 42.54393.38NoNo088
67B:B:C148 B:B:T102 41.81363.38NoNo068
68B:B:F151 B:B:I123 16.27555.02YesYes096
69B:B:F151 B:B:I157 14.602611.3YesYes097
70B:B:C149 B:B:I157 28.8114.91NoYes087
71B:B:I123 B:B:I171 14.82044.42YesNo1866
72B:B:I157 B:B:I171 14.58844.42YesNo076
73B:B:C148 B:B:S160 16.08653.44NoYes766
74B:B:C148 B:B:L190 24.9976.35NoNo765
75B:B:L190 B:B:V158 24.27044.47NoYes755
76B:B:L152 B:B:V158 10.40982.98NoYes735
77B:B:F199 B:B:V158 12.46076.55YesYes795
78B:B:S160 B:B:V187 14.62584.85YesNo769
79B:B:H183 B:B:V187 10.23745.54YesNo799
80R:R:F173 R:R:I169 95.00875.02YesNo078
81R:R:C392 R:R:I169 94.99924.91NoNo098
82R:R:C392 R:R:S166 48.026.89NoYes099
83R:R:F188 R:R:S166 47.04175.28YesYes089
84R:R:F188 R:R:V387 1003.93YesNo089
85R:R:V387 R:R:Y191 1006.31NoYes098
86R:R:M237 R:R:Y191 83.89495.99YesYes298
87R:R:M237 R:R:Y234 84.91753.59YesYes297
88L:L:T6 R:R:Y234 42.76068.74YesYes207
89L:L:T6 R:R:H302 81.4638.21YesYes206
90R:R:H302 R:R:L298 1003.86YesNo066
91R:R:L298 R:R:V293 1002.98NoYes066
92L:L:K1 R:R:V293 1004.55NoYes3106
93L:L:K1 R:R:E294 1006.75NoNo003
94R:R:E294 R:R:P104 1003.14NoNo033
95R:R:D103 R:R:P104 1004.83NoNo033
96R:R:D103 R:R:E106 1003.9NoYes034
97R:R:E106 R:R:M133 1005.41YesYes345
98H:H:?2 R:R:M133 1007.59YesYes305
99H:H:?2 R:R:W128 10010.19YesYes305
100L:L:?38 R:R:W128 10014.17YesYes305
101L:L:?38 L:L:T36 23.58657.33YesYes000
102L:L:T36 R:R:W79 21.08984.85YesYes006
103L:L:Y37 R:R:W79 27.212214.47YesYes006
104E:E:P85 L:L:Y37 52.19285.56NoYes090
105E:E:P85 E:E:W84 48.86276.76NoYes099
106E:E:T73 E:E:W84 42.20234.85YesYes099
107E:E:R37 E:E:T73 12.21423.88YesYes449
108R:R:C392 R:R:F170 47.0338.38NoYes098
109R:R:F170 R:R:F188 93.95896.43YesYes088
110R:R:F170 R:R:L176 47.06563.65YesYes089
111R:R:Q383 R:R:Y191 53.716413.53YesYes298
112R:R:F356 R:R:Q383 53.18164.68YesYes279
113L:L:T6 R:R:F356 42.33685.19YesYes207
114R:R:M230 R:R:Y234 41.76525.99NoYes267
115R:R:H302 R:R:M230 40.93646.57YesNo266
116L:L:?38 R:R:Y131 42.17585.83YesYes305
117R:R:W79 R:R:Y131 21.100723.15YesYes365
118L:L:?38 R:R:S129 38.29043.74YesYes307
119R:R:D77 R:R:S129 13.87615.89YesYes397
120L:L:Y37 R:R:D77 27.20673.45YesYes009
121R:R:D77 R:R:Y131 13.87955.75YesYes395
122E:E:F92 E:E:T73 26.65826.49YesYes489
123E:E:F92 E:E:L41 14.440810.96YesYes087
124E:E:E68 E:E:F44 14.99442.33NoYes449
125E:E:F92 E:E:L69 11.10647.31YesYes488
126E:E:F44 E:E:L69 11.11121.92YesYes498
127R:R:K110 R:R:S129 18.60149.18YesYes387
128R:R:K110 R:R:W118 17.778822.05YesYes389
129R:R:T75 R:R:W118 13.89498.49NoYes059
130E:E:D90 R:R:T75 13.61735.78NoNo095
131E:E:D90 R:R:Y56 13.33989.2NoYes093
132R:R:M48 R:R:W79 11.67053.49NoYes366
133R:R:M48 R:R:R45 11.11651.24NoNo067
134R:R:M49 R:R:R45 10.56091.24NoNo047
135R:R:H277 R:R:L298 10.62463.86YesNo076
136R:R:F356 R:R:I380 10.70127.54YesNo076
137R:R:H381 R:R:I380 10.60323.98YesNo096
138B:B:D323 B:B:T321 76.18647.23NoNo577
139B:B:C317 B:B:S316 71.33443.44NoNo079
140B:B:M61 B:B:W63 71.55885.82YesYes567
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


2D representation of the interactions of this orthosteric/allosteric ligand.


Links and nodes colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
E:E:P85 E:E:W84 6.76 0 No Yes 9 9 1 2
E:E:P85 L:L:Y37 5.56 0 No Yes 9 0 1 0
E:E:P85 R:R:R126 4.32 0 No No 9 4 1 2
L:L:K1 R:R:V293 4.55 31 No Yes 0 6 0 1
L:L:K1 R:R:E294 6.75 31 No No 0 3 0 1
L:L:C2 R:R:Y299 5.38 2 No No 0 7 0 1
L:L:N3 R:R:W361 18.08 0 No No 0 4 0 1
L:L:N3 R:R:R362 4.82 0 No Yes 0 4 0 1
L:L:T6 R:R:Y234 8.74 2 Yes Yes 0 7 0 1
L:L:T6 R:R:H302 8.21 2 Yes Yes 0 6 0 1
L:L:T6 R:R:V305 4.76 2 Yes No 0 7 0 1
L:L:T6 R:R:F356 5.19 2 Yes Yes 0 7 0 1
L:L:C7 R:R:H302 10.32 2 No Yes 0 6 0 1
L:L:T9 R:R:H381 4.11 0 No Yes 0 9 0 1
L:L:Q10 R:R:H226 3.71 2 No No 0 6 0 1
L:L:Q10 R:R:M230 5.44 2 No No 0 6 0 1
L:L:Q10 R:R:H302 6.18 2 No Yes 0 6 0 1
L:L:R11 R:R:V293 3.92 31 No Yes 0 6 0 1
L:L:L12 R:R:H377 6.43 0 No Yes 0 7 0 1
L:L:N14 R:R:V293 4.43 0 No Yes 0 6 0 1
L:L:F15 R:R:K141 18.61 0 No No 0 3 0 1
L:L:L16 R:R:A145 3.15 22 Yes No 0 4 0 1
L:L:L16 R:R:Y149 4.69 22 Yes Yes 0 5 0 1
L:L:L16 R:R:V206 2.98 22 Yes No 0 3 0 1
L:L:V17 R:R:V206 4.81 19 No No 0 3 0 1
L:L:V17 R:R:V212 4.81 19 No No 0 3 0 1
L:L:V17 R:R:L291 4.47 19 No Yes 0 6 0 1
L:L:R18 R:R:P104 8.65 0 No No 0 3 0 1
L:L:S20 R:R:Y146 3.82 22 No No 0 2 0 1
L:L:L23 R:R:Y146 5.86 22 Yes No 0 2 0 1
L:L:L23 R:R:Y149 7.03 22 Yes Yes 0 5 0 1
L:L:T30 R:R:F99 5.19 3 Yes Yes 0 5 0 1
L:L:T30 R:R:D101 7.23 3 Yes Yes 0 4 0 1
L:L:T30 R:R:F102 3.89 3 Yes Yes 0 4 0 1
L:L:V32 R:R:N135 8.87 0 No Yes 0 3 0 1
L:L:S34 R:R:E123 10.06 0 No No 0 4 0 1
L:L:S34 R:R:N124 5.96 0 No No 0 5 0 1
L:L:T36 R:R:W79 4.85 0 Yes Yes 0 6 0 1
L:L:Y37 R:R:D77 3.45 0 Yes Yes 0 9 0 1
L:L:Y37 R:R:G78 10.14 0 Yes No 0 5 0 1
L:L:Y37 R:R:W79 14.47 0 Yes Yes 0 6 0 1
L:L:?38 R:R:W128 14.17 3 Yes Yes 0 5 0 1
L:L:?38 R:R:S129 3.74 3 Yes Yes 0 7 0 1
L:L:?38 R:R:Y131 5.83 3 Yes Yes 0 5 0 1
R:R:M48 R:R:W79 3.49 3 No Yes 6 6 2 1
R:R:M48 R:R:Y98 9.58 3 No Yes 6 4 2 2
R:R:D77 R:R:L80 4.07 3 Yes Yes 9 5 1 2
R:R:D77 R:R:W82 8.93 3 Yes Yes 9 9 1 2
R:R:D77 R:R:S129 5.89 3 Yes Yes 9 7 1 1
R:R:D77 R:R:Y131 5.75 3 Yes Yes 9 5 1 1
R:R:W79 R:R:Y98 5.79 3 Yes Yes 6 4 1 2
R:R:F99 R:R:W79 13.03 3 Yes Yes 5 6 1 1
R:R:F102 R:R:W79 4.01 3 Yes Yes 4 6 1 1
R:R:W79 R:R:Y131 23.15 3 Yes Yes 6 5 1 1
R:R:L80 R:R:V108 4.47 3 Yes Yes 5 7 2 2
R:R:L80 R:R:Y131 5.86 3 Yes Yes 5 5 2 1
R:R:V108 R:R:W82 3.68 3 Yes Yes 7 9 2 2
R:R:K110 R:R:W82 18.57 3 Yes Yes 8 9 2 2
R:R:S129 R:R:W82 4.94 3 Yes Yes 7 9 1 2
R:R:C95 R:R:F102 5.59 3 Yes Yes 9 4 2 1
R:R:C95 R:R:V108 3.42 3 Yes Yes 9 7 2 2
R:R:C134 R:R:C95 7.28 3 No Yes 9 9 2 2
R:R:F99 R:R:Y98 5.16 3 Yes Yes 5 4 1 2
R:R:F102 R:R:F99 15 3 Yes Yes 4 5 1 1
R:R:D101 R:R:P100 3.22 0 Yes No 4 4 1 2
R:R:D101 R:R:N135 6.73 0 Yes Yes 4 3 1 1
R:R:F102 R:R:Y131 3.09 3 Yes Yes 4 5 1 1
R:R:C134 R:R:F102 11.17 3 No Yes 9 4 2 1
R:R:F102 R:R:N135 7.25 3 Yes Yes 4 3 1 1
R:R:D103 R:R:P104 4.83 0 No No 3 3 2 1
R:R:E294 R:R:P104 3.14 0 No No 3 3 1 1
R:R:V108 R:R:Y131 12.62 3 Yes Yes 7 5 2 1
R:R:K110 R:R:S129 9.18 3 Yes Yes 8 7 2 1
R:R:E123 R:R:H121 18.46 0 No Yes 4 4 1 2
R:R:H121 R:R:W128 6.35 3 Yes Yes 4 5 2 1
H:H:?2 R:R:H121 4.6 3 Yes Yes 0 4 2 2
H:H:?2 R:R:W128 10.19 3 Yes Yes 0 5 2 1
R:R:S129 R:R:Y131 6.36 3 Yes Yes 7 5 1 1
R:R:L142 R:R:Y146 9.38 0 No No 2 2 2 1
R:R:D373 R:R:L148 5.43 0 No No 5 5 2 2
R:R:H377 R:R:L148 10.29 0 Yes No 7 5 1 2
R:R:Y149 R:R:Y150 9.93 22 Yes No 5 4 1 2
R:R:L202 R:R:Y149 5.86 0 No Yes 7 5 2 1
R:R:A152 R:R:H381 7.32 0 No Yes 7 9 2 1
R:R:H156 R:R:I198 11.93 0 Yes No 7 7 2 2
R:R:H156 R:R:H381 10.75 0 Yes Yes 7 9 2 1
R:R:H226 R:R:I198 3.98 0 No No 6 7 1 2
R:R:H201 R:R:V205 12.45 0 No Yes 6 7 1 2
R:R:L291 R:R:V205 2.98 19 Yes Yes 6 7 1 2
R:R:P207 R:R:V206 5.3 0 No No 3 3 2 1
R:R:C289 R:R:V212 5.12 19 No No 9 3 2 1
R:R:L291 R:R:V212 4.47 19 Yes No 6 3 1 1
R:R:M230 R:R:Y234 5.99 2 No Yes 6 7 1 1
R:R:H302 R:R:M230 6.57 2 Yes No 6 6 1 1
R:R:M237 R:R:Y234 3.59 2 Yes Yes 9 7 2 1
R:R:V305 R:R:Y234 13.88 2 No Yes 7 7 1 1
R:R:L309 R:R:Y234 5.86 2 No Yes 7 7 2 1
R:R:F356 R:R:Y234 14.44 2 Yes Yes 7 7 1 1
R:R:M237 R:R:Q383 5.44 2 Yes Yes 9 9 2 2
R:R:C289 R:R:L291 3.17 19 No Yes 9 6 2 1
R:R:L298 R:R:V293 2.98 0 No Yes 6 6 2 1
R:R:H296 R:R:Y299 4.36 0 No No 2 7 2 1
R:R:H302 R:R:L298 3.86 2 Yes No 6 6 1 2
R:R:F356 R:R:L309 3.65 2 Yes No 7 7 1 2
R:R:G353 R:R:Q355 4.93 2 No Yes 9 8 2 2
R:R:F356 R:R:G353 3.01 2 Yes No 7 9 1 2
R:R:F356 R:R:Q355 9.37 2 Yes Yes 7 8 1 2
R:R:Q355 R:R:Q383 11.52 2 Yes Yes 8 9 2 2
R:R:F356 R:R:I380 7.54 2 Yes No 7 6 1 2
R:R:F356 R:R:Q383 4.68 2 Yes Yes 7 9 1 2
R:R:G369 R:R:R362 6 0 No Yes 4 4 2 1
R:R:R362 R:R:Y372 9.26 0 Yes Yes 4 7 1 2
R:R:D373 R:R:R362 14.29 0 No Yes 5 4 2 1
R:R:H377 R:R:H381 9.55 0 Yes Yes 7 9 1 1
R:R:H381 R:R:I380 3.98 0 Yes No 9 6 1 2
L:L:A8 R:R:H377 2.93 0 No Yes 0 7 0 1
L:L:A13 R:R:H201 2.93 0 No No 0 6 0 1
R:R:D101 R:R:T138 2.89 0 Yes No 4 2 1 2
L:L:G33 R:R:W128 2.81 0 No Yes 0 5 0 1
L:L:A5 R:R:F356 2.77 0 No Yes 0 7 0 1
L:L:F15 R:R:A145 2.77 0 No No 0 4 0 1
E:E:I123 R:R:Y299 2.42 0 No No 9 7 2 1
L:L:N22 R:R:G209 1.7 0 No No 0 3 0 1
R:R:G209 R:R:N208 1.7 0 No No 3 3 1 2
R:R:M306 R:R:P360 1.68 0 No No 4 5 1 2
L:L:P29 R:R:N135 1.63 0 No Yes 0 3 0 1
L:L:T6 R:R:M306 1.51 2 Yes No 0 4 0 1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

ShowSimilarityNetwork TypeNameLigandDescription
75.00Single7TZFAmylin7TZF-CT (AMY3)-Amylin-Gs/β1/γ2; RAMP3
71.43Single7TYXAmylin7TYX-CT (AMY2)-Amylin-Gs/β1/γ2; RAMP2
67.86Single8F0KPramlintide Analogue San3858F0K-CT (AMY3)-Pramlintide Analogue San385-Gs/β1/γ2; RAMP3
64.71Single8F2BPramlintide Analogue San458F2B-CT (AMY3)-Pramlintide Analogue San45-Gs/β1/γ2; RAMP3
64.52Single7TYYCalcitonin-17TYY-CT (AMY2)-Calcitonin-1-Gs/β1/γ2; RAMP2
64.29Single7TYNCalcitonin-17TYN-CT-Calcitonin-1-Gs/β1/γ2
63.33Single8F2APramlintide Analogue San3858F2A-CT (AMY3)-Pramlintide Analogue San385-Gs/β1/γ2; RAMP3
62.96Single7TYWCalcitonin-17TYW-CT (AMY1)-Calcitonin-1-Gs/β1/γ2; RAMP1
62.07Single7TYLAmylin7TYL-CT-Amylin-Gs/β1/γ2
57.14Single7TYHCalcitonin-17TYH-CT (AMY2)-Calcitonin-1-Gs/β1/γ2; RAMP2
57.14Single8F0JPramlintide Analogue San458F0J-CT-Pramlintide Analogue San45-Gs/β1/γ2
54.55Single7TYOCalcitonin7TYO-CT-Calcitonin-Gs/β1/γ2
53.12Single9AUCCalcitonin gene-related peptide-19AUC-CT (AMY1)-Calcitonin gene-related peptide-1-Gs/β1/γ2; RAMP1
52.94Single6E3YCalcitonin gene-related peptide-16E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/β1/γ2; RAMP1
44.83Single6UUNAdrenomedullin6UUN-CT Like (AM1)-Adrenomedullin-Gs/β1/γ2; RAMP2
43.75Single6UVAAdrenomedullin-26UVA-CT Like (AM2)-Adrenomedullin-2-Gs/β1/γ2; RAMP3
42.42Single6UUSAdrenomedullin6UUS-CT Like (AM2)-Adrenomedullin-Gs/β1/γ2; RAMP3
40.74Single7VVNPTH7VVN-PTH1-PTH-Gs/β1/γ2
40.62Single6P9YPACAP6P9Y-PAC1-PACAP-Gs/β1/γ2
40.00Single8FLULong-Acting PTH8FLU-PTH1-Long-Acting PTH-Gs/β1/γ2
38.89Single7VVMPTH7VVM-PTH1-PTH-Gs/β1/γ2
38.71Single6NIYAdrenomedullin6NIY-CT-Adrenomedullin-Gs/β1/γ2
38.71Single7TYIAmylin7TYI-CT-Amylin-Gs/β1/γ2
38.46Single7F16TIP397F16-PTH2-TIP39-Gs/β1/γ2
38.24Single6NBHLong-Acting PTH Analog6NBH-PTH1-Long-Acting PTH Analog-Gs/β1/γ2
38.24Single6PB1Urocortin6PB1-CRF2-Urocortin-chim(NtGi1-Gs)/β1/γ2
37.84Single7Y36Teriparatide7Y36-PTH1-Teriparatide-Gs/β1/γ2
37.14Single6PB0Urocortin6PB0-CRF1-Urocortin-chim(NtGi1-Gs)/β1/γ2
37.04Single7WCNAR2314537WCN-GPR119-AR231453-Gs/β1/γ2
36.36Single6FJ3PTH6FJ3-PTH1-PTH
36.36Single8E3XPACAP278E3X-PAC1-PACAP27-Gs/β1/γ2
36.11Single6LPBPACAP6LPB-PAC1-PACAP-Gs/β1/γ1
36.11Single8FLSAbaloparatide8FLS-PTH1-Abaloparatide-Gs/β1/γ2
35.71Single7XZ6APD6687XZ6-GPR119-APD668-Gs/β1/γ2
35.29Single6P9XCorticoliberin6P9X-CRF1-Corticoliberin-Gs/β1/γ2
35.29Single7FIYTirzepatide7FIY-GIP-Tirzepatide-Gs/β1/γ2
35.29Single8HAOPTH8HAO-PTH1-PTH-chim(NtGi1-Gs)/β1/γ2
35.14Single9JR2PTH9JR2-PTH1-PTH-chim(NtGi1L-Gs-CtGq)/β1/γ2
34.38Single7V9MSomatoliberin7V9M-GHRH (SV1)-Somatoliberin-Gs/β1/γ2
34.29Single6WZGSecretin6WZG-Secretin-Secretin-Gs/β1/γ2
34.29Single7KI1Taspoglutide7KI1-GLP-1-Taspoglutide-Gs/β1/γ2
34.29Single7TS0Urocortin7TS0-CRF2-Urocortin-chim(NtGi1L-Go)/β1/γ2
34.29Single7VVLPTH7VVL-PTH1-PTH-Gs/β1/γ2
34.29Single8HAFPTHrP(1-36)8HAF-PTH1-PTHrP(1-36)-chim(NtGi1-Gs)/β1/γ2
34.21Single8FLQPTH8FLQ-PTH1-PTH-Gs/β1/γ2
34.21Single9JR3PTH9JR3-PTH1-PTH-chim(NtGi1L-Gs-CtGq)/β1/γ2
33.33Single7RTBPeptide-197RTB-GLP-1-Peptide-19-Gs/β1/γ2
33.33Single7WBJPACAP277WBJ-VPAC1-PACAP27-Gs/β1/γ2
33.33Single7Y35Abaloparatide7Y35-PTH1-Abaloparatide-Gs/β1/γ2
33.33Single8E3YPACAP278E3Y-VPAC1-PACAP27-Gs/β1/γ2
33.33Single8IJANiacin8IJA-HCA2-Niacin-Gi1/β1/γ2
32.35Single6NBFLong-Acting PTH Analog6NBF-PTH1-Long-Acting PTH Analog-Gs/β1/γ2
32.35Single7CZ5Somatoliberin7CZ5-GHRH-Somatoliberin-Gs/β1/γ2
32.35Single7RA3GIP7RA3-GIP-GIP-chim(NtGi1-Gs)/β1/γ2
32.35Single7VABNon-Acylated Tirzepatide7VAB-GIP-Non-Acylated Tirzepatide-chim(NtGi1-Gs)/β1/γ2
32.26Single7CUMPhospholipid7CUM-GABAB1, GABAB2-CGP54626-Phospholipid
32.26Single7CUMPhospholipid7CUM-GABAB1, GABAB2-CGP54626-Phospholipid
32.26Single7TRYUrocortin7TRY-CRF2-Urocortin-chim(NtGi1-G11)/β1/γ2
32.26Single8JZZC5a-desArg8JZZ-C5a1-C5a-desArg-Go/β1/γ2
32.14Single7MTRADX551647MTR-mGlu2; mGlu2-Glutamate-ADX55164
32.14Single8VHFMBX-29828VHF-GPR119-MBX-2982-Gs/β1/γ2
31.58Single6WPWGlucagon derivative ZP37806WPW-Glucagon-Glucagon derivative ZP3780-Gs/β1/γ2
31.43Single6VCBGLP-16VCB-GLP-1-GLP-1-LSN3160440-Gs/β1/γ2
31.43Single7DTYGIP7DTY-GIP-GIP-Gs/β1/γ2
31.43Single7S1MEx4-D-Ala7S1M-GLP-1-Ex4-D-Ala-Gs/β1/γ2
31.43Single7VVKPTH7VVK-PTH1-PTH-Gs/β1/γ2
31.03Single7LLLExendin-47LLL-GLP-1-Exendin-4-Gs/β1/γ2
30.77Single8I7VAcipimox8I7V-HCA2-Acipimox-Gi1/β1/γ2
30.77Single8J6PNiacin8J6P-HCA2-Niacin-Compound 9n-Gi1/β1/γ2
30.77Single8JHNMMF8JHN-HCA2-MMF-Go/β1/γ2
30.77Single8T1WCVN4248T1W-GPR6-CVN424
30.77Consensusgi_hcaOrthosteric Ligand8J6R-HCA2-MK6892-Gi1/β1/γ2 8JIM-HCA2-MMF-Gi1/β1/γ2 8IHI-HCA2-Acifran-Gi1/β1/γ2 8IHH-HCA2-LUF6283-Gi1/β1/γ2 8I7V-HCA2-Acipimox-Gi1/β1/γ2 8I7W-HCA2-GSK256073-Gi1/β1/γ2
30.77Consensushca2_onOrthosteric Ligand8J6R-HCA2-MK6892-Gi1/β1/γ2 8JIM-HCA2-MMF-Gi1/β1/γ2 8I7V-HCA2-Acipimox-Gi1/β1/γ2 8I7W-HCA2-GSK256073-Gi1/β1/γ2 8IHH-HCA2-LUF6283-Gi1/β1/γ2 8IHI-HCA2-Acifran-Gi1/β1/γ2
30.77Consensushca2_on_gpOrthosteric Ligand8J6R-HCA2-MK6892-Gi1/β1/γ2 8IHI-HCA2-Acifran-Gi1/β1/γ2 8IHH-HCA2-LUF6283-Gi1/β1/γ2 8I7V-HCA2-Acipimox-Gi1/β1/γ2 8JIM-HCA2-MMF-Gi1/β1/γ2 8I7W-HCA2-GSK256073-Gi1/β1/γ2
30.77Consensushca_on_gpOrthosteric Ligandhca2_on_gp
30.56Single5VAIGLP-15VAI-GLP-1-GLP-1-Gs/β1/γ2
30.56Single6LMLGlucagon6LML-Glucagon-Glucagon-Gi1/β1/γ1
30.56Single7D68GLP-27D68-GLP-2-GLP-2-Gs/β1/γ2
30.56Single7VVJPTHrP(1-36)7VVJ-PTH1-PTHrP(1-36)-Gs/β1/γ2
30.56Single8FLTM-PTH(1-14)8FLT-PTH1-M-PTH(1-14)-Gs/β1/γ2
30.30Single6M1IPACAP6M1I-PAC1-PACAP-Gs/β1/γ2
30.30Single6WI9Secretin6WI9-Secretin-Secretin-Gs/β1/γ2
30.30Single7FINPeptide-20; GGL7FIN-GIP-Peptide-20; GGL-Gs/β1/γ2
30.30Single8HA0PTH8HA0-PTH1-PTH-chim(NtGi1-Gs)/β1/γ2
30.30Single8YW3Retatrutide8YW3-GLP-1-Retatrutide-Gs/β1/γ2
30.30Single8YW4Retatrutide8YW4-GIP-Retatrutide-chim(NtGi1-Gs)/β1/γ22
30.00Consensuss1p_onOrthosteric Ligands1p1_on s1p3_on s1p5_on
30.00Consensuss1p_on_gpOrthosteric Ligands1p1_on_gp s1p3_on_gp s1p5_on_gp
29.73Single7DUQGLP-17DUQ-GLP-1-GLP-1-PubChem 156022738-Gs/β1/γ2
29.73Single7RBTTirzepatide7RBT-GIP-Tirzepatide-PubChem 163183774-chim(NtGi1-Gs)/β1/γ2
29.63Single8J6JGSK2560738J6J-HCA2-GSK256073-Gi1/β1/γ2
29.63Single8UUJFCH-22964138UUJ-HCA2-FCH-2296413-Gi1/β1/γ2
29.63Single8ZRKGSK-12922638ZRK-GPR119-GSK-1292263-Gs/β1/γ2
29.41Single7LLYOxyntomodulin7LLY-GLP-1-Oxyntomodulin-Gs/β1/γ2
29.41Single8E3ZVIP8E3Z-VPAC1-VIP-Gs/β1/γ2
29.17Single8H2GNiacin8H2G-HCA2-Niacin-Gi1/β1/γ2
29.17Single8K5BNiacin8K5B-HCA2-Niacin
29.03Single7W0PElabela7W0P-Apelin-Elabela-Gi1/β1/γ2
29.03Single8JIQPeptide-158JIQ-Glucagon-Peptide-15-Gs/β1/γ2
29.03Consensusmop_offOrthosteric Ligand4DKL-μ-β-Funaltrexamine 8QOT-μ-Nanobody-E 7UL4-μ-Alvimopan
28.57Single6NBILong-Acting PTH Analog6NBI-PTH1-Long-Acting PTH Analog-Gs/β1/γ2
28.57Single7D3SSecretin7D3S-Secretin-Secretin-Gs/β1/γ2
28.57Single7EW7SEW28717EW7-S1P1-SEW2871-Gi1/β1/γ2
28.57Single7KI0Semaglutide7KI0-GLP-1-Semaglutide-Gs/β1/γ2
28.57Single7RGPTirzepatide7RGP-GLP-1-Tirzepatide-chim(NtGi1-Gs)/β1/γ2
28.57Single8IHBGSK2560738IHB-HCA2-GSK256073-Gi1/β1/γ2
28.57Single8IHHLUF62838IHH-HCA2-LUF6283-Gi1/β1/γ2
28.57Single8T1VPubChem 1183102098T1V-GPR6-PubChem 118310209-Na
28.57Single9J1Pg1:Ox9J1P-GLP-1-g1:Ox-chim(NtGi1-Gs)/β1/γ2
28.57Consensus5ht_offOrthosteric Ligand5ht2_off 5ht1_off
28.57Consensusclass-a_offOrthosteric Ligandsensory_off alicarboxylic_off amine_off lipid_off nucleotide_off peptide_off protein_off
28.57Consensusprotein_offOrthosteric Ligandchemokine_off grh_off
28.21Single8JIRSAR4258998JIR-GLP-1-SAR425899-chim(NtGi1-Gs)/β1/γ2
28.12Single6DO1Angiotensin-like peptide S1I86DO1-AT1-Angiotensin-like peptide S1I8
28.12Single6WHCGlu16 analog of GCG6WHC-Glucagon-Glu16 analog of GCG-Gs/β1/γ2
28.12Single7VBINon-Acylated Tirzepatide7VBI-GLP-1-Non-Acylated Tirzepatide-Gs/β1/γ2
28.12Single7XMSSomatostatin-147XMS-SST4-Somatostatin-14-Gi1/β1/γ2
28.12Single8Z7JAgonistic antibody8Z7J-Apelin-Agonistic antibody-Gi1/β1/γ2
28.12Consensusgq_class-aOrthosteric Ligandgq_peptide gq_amine gq_nucleotide
27.78Single5NX2GLP-1 (Truncated)5NX2-GLP-1-GLP-1 (Truncated)
27.78Single6B3JExendin-P56B3J-GLP-1-Exendin-P5-Gs/β1/γ2
27.78Single7VQXPACAP277VQX-VPAC1-PACAP27-Gs/β1/γ2
27.78Consensusgq_peptideOrthosteric Ligandgq_cck gq_kisspeptin gq_bradykinin gq_bombesin gq_angiotensin
27.59Single6W2YPubChem 237279706W2Y-GABAB1; GABAB1-PubChem 5311042-PubChem 23727970
27.59Single7DFPSpiperone7DFP-D2-Spiperone
27.59Single7EVYSiponimod7EVY-S1P1-Siponimod-Gi1/β1/γ2
27.59Single7WCMMBX-29827WCM-GPR119-MBX-2982-Gs/β1/γ2
27.59Consensuss1p1_onOrthosteric Ligand7VIE-S1P1-S1P-Gi1/β1/γ2 7VIF-S1P1-S-FTY720-P-Gi1/β1/γ2 7VIG-S1P1-CBP-307-Gi1/β1/γ2 7EVY-S1P1-Siponimod-Gi1/β1/γ2 7EVZ-S1P1-Cenerimod-Gi1/β1/γ2 7EW0-S1P1-Ozanimod-Gi1/β1/γ2 7EW7-S1P1-SEW2871-Gi1/β1/γ2
27.59Consensuss1p1_on_gpOrthosteric Ligand7VIE-S1P1-S1P-Gi1/β1/γ2 7VIF-S1P1-S-FTY720-P-Gi1/β1/γ2 7VIG-S1P1-CBP-307-Gi1/β1/γ2 7EVY-S1P1-Siponimod-Gi1/β1/γ2 7EVZ-S1P1-Cenerimod-Gi1/β1/γ2 7EW0-S1P1-Ozanimod-Gi1/β1/γ2 7EW7-S1P1-SEW2871-Gi1/β1/γ2
27.03Single6LMKGlucagon6LMK-Glucagon-Glucagon-Gs/β1/γ2
27.03Single8WWNMCH8WWN-MCH1-MCH-Gi1/β1/γ2
26.92Single2YDOAdenosine2YDO-A2A-Adenosine
26.92Single8IY9Niacin8IY9-HCA2-Niacin-Go/β1/γ2
26.92Single8JIMMMF8JIM-HCA2-MMF-Gi1/β1/γ2
26.92Single8K5CAcipimox8K5C-HCA2-Acipimox
26.92Single8W88SEP-3638568W88-TA1-SEP-363856-Gs/β1/γ2
26.92Consensushca_onOrthosteric Ligandhca2_on
26.67Single4BVNCyanopindolol4BVN-β1-Cyanopindolol-Na
26.67Single6BQHRitanserin6BQH-5-HT2C-Ritanserin
26.67Single7EVZCenerimod7EVZ-S1P1-Cenerimod-Gi1/β1/γ2
26.67Single7MTSADX551647MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/β1/γ2
26.67Single7SK7CCX6627SK7-ACKR3-CXCL12-CCX662
26.67Single8IJDMK68928IJD-HCA2-MK6892-Gi1/β1/γ2
26.67Consensus5ht2c_offOrthosteric Ligand6BQH-5-HT2C-Ritanserin
26.67Consensusclass-a_onOrthosteric Ligandsensory_on alicarboxylic_on amine_on lipid_on nucleotide_on peptide_on protein_on
26.67Consensusd2_offOrthosteric Ligand6CM4-D2-Risperidone 6LUQ-D2-Haloperidol 7DFP-D2-Spiperone
26.67Consensusgi_s1pOrthosteric Ligand7VIE-S1P1-S1P-Gi1/β1/γ2 7EW3-S1P3-S1P-Gi1/β1/γ2 7EVY-S1P1-Siponimod-Gi1/β1/γ2 7EW1-S1P5-Siponimod-Gi1/β1/γ2 7VIF-S1P1-S-FTY720-P-Gi1/β1/γ2 7VIG-S1P1-CBP-307-Gi1/β1/γ2 7EVZ-S1P1-Cenerimod-Gi1/β1/γ2 7EW4-S1P3-CYM5541-Gi1/β1/γ2 7EW2-S1P3-Fingolimod-Gi1/β1/γ2 7EW0-S1P1-Ozanimod-Gi1/β1/γ2 7EW7-S1P1-SEW2871-Gi1/β1/γ2
26.47Single7FIMTirzepatide7FIM-GLP-1-Tirzepatide-Gs/β1/γ2
26.47Single7WUIIP157WUI-ADGRG2-IP15-chim(NtGi1-Gs)/β1/γ2
26.47Single8YW5Retatrutide8YW5-Glucagon-Retatrutide-Gs/β1/γ2
26.47Consensuscxcr3_on_gpOrthosteric Ligand8HNK-CXCR3-CXCL11-Gi1/β1/γ2 8HNL-CXCR3-PS372424-Gi1/β1/γ2
26.47Consensusgi_class-aOrthosteric Ligandgi_peptide gi_sensory gi_alicarboxylic gi_amine gi_lipid gi_nucleotide gi_protein
26.47Consensusprotein_onOrthosteric Ligandchemokine_on chemerin_on
26.32Consensusbb2_onOrthosteric Ligand7W40-BB2-Bombesin-chim(NtGi1L-Gq)/β1/γ2 7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/β1/γ2
26.32Consensusbb2_on_gpOrthosteric Ligand7W40-BB2-Bombesin-chim(NtGi1L-Gq)/β1/γ2 7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/β1/γ2
26.32Consensusbombesin_onOrthosteric Ligandbb2_on
26.32Consensusbombesin_on_gpOrthosteric Ligandbb2_on_gp
26.32Consensusgq_bombesinOrthosteric Ligand7W40-BB2-Bombesin-chim(NtGi1L-Gq)/β1/γ2 7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/β1/γ2
25.93Single5OLZPubChem 1355666095OLZ-A2A-PubChem 135566609-Na
25.93Single5OM1PubChem 1355666095OM1-A2A-PubChem 135566609-Na
25.93Single8JIINiacin8JII-HCA2-Niacin-Compound 9n-Gi1/β1/γ2
25.93Single8K5DGSK2560738K5D-HCA2-GSK256073
25.93Single8W8ARO52563908W8A-TA1-RO5256390-chim(NtGi1L-Gs)/β1/γ2
25.93Single8ZSSRO52633978ZSS-TA1-RO5263397-chim(NtGi1-Gs)/β1/γ2
25.93Consensusalicarboxylic_on_gpOrthosteric Ligandsuccinate_on_gp hca_on_gp
25.93Consensusgi_alicarboxylicOrthosteric Ligandgi_hca gi_succinate
25.81Single3NY9ICI118-5513NY9-β2-ICI118-551
25.81Single4UG2CGS216804UG2-A2A-CGS21680
25.81Single6W2YPubChem 237279706W2Y-GABAB1; GABAB1-PubChem 5311042-PubChem 23727970
25.81Single7F8WGastrin-177F8W-CCKB-Gastrin-17-chim(NtGsL-Gq)/β1/γ2
25.81Single7YJ4INSL57YJ4-RXFP4-INSL5-Gi2/β1/γ2
25.81Single8XZFWN5618XZF-Apelin-WN561-Gi1/β1/γ2
25.81Consensuscxcr3_onOrthosteric Ligand8HNK-CXCR3-CXCL11-Gi1/β1/γ2 8HNL-CXCR3-PS372424-Gi1/β1/γ2
25.71Single5YQZGlucagon analogue5YQZ-Glucagon-Glucagon analogue
25.71Single6X18GLP-16X18-GLP-1-GLP-1-Gs/β1/γ2
25.71Single8WWKMCH8WWK-MCH1-MCH-Gi1/β1/γ2
25.71Single8WWMMCH8WWM-MCH1-MCH-Gi1/β1/γ2
25.71Consensusgi_apelinOrthosteric Ligand8XZH-Apelin-MM07-Gi1/β1/γ2 7W0M-Apelin-PubChem 122701908-Gi1/β1/γ2 8XZJ-Apelin-WN353-Gi1/β1/γ2 8XZF-Apelin-WN561-Gi1/β1/γ2 8XZG-Apelin-Apelin-13-Gi1/β1/γ2
25.71Consensussst5_on_gpOrthosteric Ligand8X8L-SST5-Cortistatin-chim(NtGi1-Gs-CtGi1)/β1/γ2 8X8N-SST5-Octreotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
25.64Single7VBHPeptide-207VBH-GLP-1-Peptide-20-Gs/β1/γ2
25.00Single5OM4PubChem 1355666095OM4-A2A-PubChem 135566609-Na
25.00Single6PS6Timolol6PS6-β2-Timolol
25.00Single6WIVPubChem 52923113; PubChem 529246456WIV-GABAB1, GABAB2-PubChem 52923113; PubChem 52924645
25.00Single7EO2FTY720-P7EO2-S1P1-FTY720-P-Gi1/β1/γ2
25.00Single7EPFNAM5977EPF-mGlu2; mGlu2-NAM597
25.00Single7TD4Siponimod7TD4-S1P1-Siponimod-Gi1/β1/γ2
25.00Single7WVWfMYFINILTL7WVW-FPR2-ALX-fMYFINILTL-Gi2/β1/γ2
25.00Single8E9ZIperoxo8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/β1/γ2
25.00Single8FLRPTHrP(1-36)8FLR-PTH1-PTHrP(1-36)-Gs/β1/γ2
25.00Single8I7WGSK2560738I7W-HCA2-GSK256073-Gi1/β1/γ2
25.00Single8J6QBeta-Hydroxybutyrate8J6Q-HCA2-β-Hydroxybutyrate-Compound 9n-Gi1/β1/γ2
25.00Single8JISPeptide-158JIS-GLP-1-Peptide-15-chim(NtGi1-Gs)/β1/γ2
25.00Single8TF5Oleic acid8TF5-GPR6-Oleic acid
25.00Single8ZPTPrRP208ZPT-PrRP-PrRP20-chim(NtGi1-Gs-CtGq)/β1/γ2
25.00Single9AVLCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVL-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi3/β2/γ2
25.00Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
25.00Consensusccr_offOrthosteric Ligandccr2_off ccr5_off
25.00Consensusclass-a_on_gpOrthosteric Ligandsensory_on_gp alicarboxylic_on_gp amine_on_gp lipid_on_gp nucleotide_on_gp peptide_on_gp protein_on_gp
25.00Consensusgi_opioidOrthosteric Ligand8F7R-μ-Endomorphin-Gi1/β1/γ2 8EF5-μ-Fentanyl-Gi1/β1/γ2 7SCG-μ-FH210-Gi1/β1/γ2 7T2H-μ-Lofentanil-Gi1/β1/γ2 7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2 8DZP-κ-momSalB-Gi1/β1/γ2 8EF6-μ-Morphine-Gi1/β1/γ2 8F7X-NOP-Nociceptin-Gi1/β1/γ2 8EFB-μ-Oliceridine-Gi1/β1/γ2 7U2L-μ-PubChem 163201242-Gi1/β1/γ2 8EFO-μ-PZM21-Gi1/β1/γ2 8EFL-μ-SR17018-Gi1/β1/γ2 8F7Q-μ-β-Endorphin-Gi1/β1/γ2 7U2K-μ-C6-guano-Gi1/β1/γ2 8EFQ-μ-Damgo-Gi1/β1/γ2 8F7S-δ-Deltorphin-Gi1/β1/γ2 8F7W-κ-Dynorphin-Gi1/β1/γ2
25.00Consensusgi_peptideOrthosteric Ligandgi_cck gi_apelin gi_compl-pept gi_endothelin gi_formylpeptide gi_galanin gi_ghrelin gi_npy gi_neurotensin gi_opioid gi_orexin gi_relaxin gi_somatostatin
25.00Consensusgi_proteinOrthosteric Ligandgi_chemokine gi_chemerin
25.00Consensusgq_muscarinicOrthosteric Ligand6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/β1/γ2
25.00Consensusm1_onOrthosteric Ligand6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/β1/γ2
25.00Consensusprotein_on_gpOrthosteric Ligandchemokine_on_gp chemerin_on_gp
25.00Consensuss1p_offOrthosteric Ligands1p1_off s1p5_off
25.00Consensussst5_onOrthosteric Ligand8X8L-SST5-Cortistatin-chim(NtGi1-Gs-CtGi1)/β1/γ2 8X8N-SST5-Octreotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
25.00Consensusta1_onOrthosteric Ligand8W87-TA1-METH-chim(NtGi1L-Gs)/β1/γ2 8W89-TA1-PEA-chim(NtGi1L-Gs)/β1/γ2 8JLP-TA1-Ralmitaront-Gs/β1/γ2 8W8A-TA1-RO5256390-chim(NtGi1L-Gs)/β1/γ2 8W88-TA1-SEP-363856-Gs/β1/γ2 8JLO-TA1-Ulotaront-Gs/β1/γ2 8JLR-TA1-A77636-chim(NtGi1-Gs)/β1/γ2 8JSO-TA1-AMPH-chim(NtGi1-Gs)/β1/γ2 8ZSP-TA1-LSD-chim(NtGi1L-Gs-CtGq)/β1/γ2
25.00Consensustrace-amine_onOrthosteric Ligandta1_on
24.39Single8JITMEDI03828JIT-Glucagon-MEDI0382-Gs/β1/γ2
24.39Single8JIUSAR4258998JIU-Glucagon-SAR425899-Gs/β1/γ2
24.32Single7EIBDes-Arg10-Kallidin7EIB-BK1-Des-Arg10-Kallidin-chim(NtGi1-Gs-CtGq)/β1/γ2
24.32Single7WVYAmyloid-Beta427WVY-FPR2-ALX-Amyloid-β42-Gi2/β1/γ2
24.32Single8FU6Glucagon derivative ZP37808FU6-Glucagon-Glucagon derivative ZP3780-Gs/β1/γ2
24.32Single8WWLMCH8WWL-MCH1-MCH-Gi1/β1/γ2
24.32Single8ZH8QRF-Amide8ZH8-QRFP-QRF-Amide-Gq/β1/γ1
24.32Consensuspeptide_onOrthosteric Ligandcck_on angiotensin_on apelin_on bombesin_on bradykinin_on compl-peptide_on endothelin_on formylpeptide_on galanin_on ghrelin_on kisspeptin_on melanocortin_on motilin_on neuromedin-u_on npy_on neurotensin_on opioid_on orexin_on relaxin_on somatostatin_on tachykinin_on trh_on vasop-oxy_on
24.32Consensuspeptide_on_gpOrthosteric Ligandcck_on_gp angiotensin_on_gp apelin_on_gp bombesin_on_gp bradykinin_on_gp compl-peptide_on_gp endothelin_on_gp formylpeptide_on_gp galanin_on_gp ghrelin_on_gp kisspeptin_on_gp melanocortin_on_gp motilin_on_gp neuromedin-u_on_gp npy_on_gp neurotensin_on_gp opioid_on_gp orexin_on_gp relaxin_on_gp somatostatin_on_gp tachykinin_on_gp trh_on_gp vasop-oxy_on_gp
24.24Single3QAKUK-4320973QAK-A2A-UK-432097
24.24Single7RKMFractalkine7RKM-US28-Fractalkine-Gi1/β1/γ2
24.24Consensuscompl-peptide_onOrthosteric Ligandc5a1_on c3a_on
24.24Consensusformylpeptide_on_gpOrthosteric Ligandfpr2-alx_on_gp fpr1-alx_on_gp
24.24Consensuss1p3_on_gpOrthosteric Ligand7EW3-S1P3-S1P-Gi1/β1/γ2 7EW4-S1P3-CYM5541-Gi1/β1/γ2 7EW2-S1P3-Fingolimod-Gi1/β1/γ2
24.24Consensussst4_onOrthosteric Ligand7XMS-SST4-Somatostatin-14-Gi1/β1/γ2 7XMT-SST4-J-2156-Gi1/β1/γ2
24.24Consensussst4_on_gpOrthosteric Ligand7XMS-SST4-Somatostatin-14-Gi1/β1/γ2 7XMT-SST4-J-2156-Gi1/β1/γ2
24.14Single2YDVNECA2YDV-A2A-NECA
24.14Single3UON3-quinuclidinyl-benzilate3UON-M2-3-quinuclidinyl-benzilate
24.14Single4UHRCGS216804UHR-A2A-CGS21680
24.14Single5A8E7-Methylcyanopindolol5A8E-β1-7-Methylcyanopindolol-Na
24.14Single5G53NECA5G53-A2A-NECA-Gs
24.14Single5V54Methiothepin5V54-5-HT1B-Methiothepin
24.14Single6GT3Imaradenant6GT3-A2A-Imaradenant-Na
24.14Single6OIJIperoxo6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/β1/γ2
24.14Single7EW1Siponimod7EW1-S1P5-Siponimod-Gi1/β1/γ2
24.14Single8EA0Iperoxo8EA0-M3-Iperoxo
24.14Single8UGWPubChem 30865998UGW-A2A-PubChem 3086599
24.14Single8ZR5Firuglipel8ZR5-GPR119-Firuglipel-Gs/β1/γ2
24.14Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/β1/γ2
24.14Consensus5ht1_offOrthosteric Ligand5ht1b_off
24.14Consensus5ht1b_offOrthosteric Ligand5V54-5-HT1B-Methiothepin
24.14Consensusgi_relaxinOrthosteric Ligand7YK7-RXFP4-DC591053-Gi2/β1/γ2 7YJ4-RXFP4-INSL5-Gi2/β1/γ2 7YK6-RXFP4-PubChem 138319674-Gi2/β1/γ2
24.14Consensusm1_on_gpOrthosteric Ligand6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/β1/γ2
24.14Consensusrelaxin_onOrthosteric Ligandrxfp4_on
24.14Consensusrelaxin_on_gpOrthosteric Ligandrxfp4_on_gp
24.14Consensuss1p5_onOrthosteric Ligand7EW1-S1P5-Siponimod-Gi1/β1/γ2
24.14Consensuss1p5_on_gpOrthosteric Ligand7EW1-S1P5-Siponimod-Gi1/β1/γ2
24.14Consensusta1_on_gpOrthosteric Ligand8W87-TA1-METH-chim(NtGi1L-Gs)/β1/γ2 8W89-TA1-PEA-chim(NtGi1L-Gs)/β1/γ2 8JLP-TA1-Ralmitaront-Gs/β1/γ2 8W8A-TA1-RO5256390-chim(NtGi1L-Gs)/β1/γ2 8W88-TA1-SEP-363856-Gs/β1/γ2 8JLO-TA1-Ulotaront-Gs/β1/γ2 8JLR-TA1-A77636-chim(NtGi1-Gs)/β1/γ2 8JSO-TA1-AMPH-chim(NtGi1-Gs)/β1/γ2 8ZSP-TA1-LSD-chim(NtGi1L-Gs-CtGq)/β1/γ2
24.14Consensustrace-amine_on_gpOrthosteric Ligandta1_on_gp
24.00Single9IQTNiacin9IQT-HCA2-Niacin-Gi1/β1/γ2
23.68Consensusbk2_onOrthosteric Ligand7F6H-BK2-Bradykinin-Gq/β1/γ2 7F6I-BK2-Kallidin-Gq/β1/γ2
23.68Consensusbk2_on_gpOrthosteric Ligand7F6H-BK2-Bradykinin-Gq/β1/γ2 7F6I-BK2-Kallidin-Gq/β1/γ2
23.68Consensusbradykinin_onOrthosteric Ligandbk2_on
23.68Consensusbradykinin_on_gpOrthosteric Ligandbk2_on_gp
23.68Consensusgq_bradykininOrthosteric Ligand7F6H-BK2-Bradykinin-Gq/β1/γ2 7F6I-BK2-Kallidin-Gq/β1/γ2
23.53Single5WF5UK-4320975WF5-A2A-UK-432097
23.53Single6LW5WKYMVm6LW5-FPR2-ALX-WKYMVm
23.53Single6VN7PACAP6VN7-VPAC1-PACAP-Gs/β1/γ2
23.53Single7T6TfMLFII7T6T-FPR1-ALX-fMLFII-Gi1/β1/γ2
23.53Single7XA3CCL27XA3-CCR2-CCL2-Gi1/β1/γ2
23.53Single9IVMGLP-1 (Truncated)9IVM-GLP-1-GLP-1 (Truncated)-LSN3318839-chim(NtGi1-Gs)/β2/γ2
23.53Single9K27PrRP319K27-PrRP-PrRP31-chim(NtGi1-Gq)/β1/γ2
23.53Consensusangiotensin_onOrthosteric Ligandat1_on
23.53Consensusat1_onOrthosteric Ligand7F6G-AT1-SAR1-AngII-Gq/β1/γ2
23.53Consensusccr2_onOrthosteric Ligand7XA3-CCR2-CCL2-Gi1/β1/γ2
23.53Consensusccr2_on_gpOrthosteric Ligand7XA3-CCR2-CCL2-Gi1/β1/γ2
23.53Consensusccr_onOrthosteric Ligandccr6_on ccr8_on ccr2_on ccr1_on ccr5_on
23.53Consensuscompl-peptide_on_gpOrthosteric Ligandc5a1_on_gp c3a_on_gp
23.53Consensusgi_somatostatinOrthosteric Ligand7WIC-SST2-Somatostatin-14-Gi1/β1/γ2 7XMS-SST4-Somatostatin-14-Gi1/β1/γ2 8X8L-SST5-Cortistatin-chim(NtGi1-Gs-CtGi1)/β1/γ2 7XMT-SST4-J-2156-Gi1/β1/γ2 7WIG-SST2-L-054,264-Gi1/β1/γ2 8X8N-SST5-Octreotide-chim(NtGi1-Gs-CtGi1)/β1/γ2 7YAE-SST2-Octreotide-Gi1/β1/γ2 7YAC-SST2-Paltusotine-Gi1/β1/γ2
23.53Consensuspeptide_offonOrthosteric Ligandpeptide_off peptide_on
23.53Consensussomatostatin_onOrthosteric Ligandsst2_on sst4_on sst5_on
23.53Consensussomatostatin_on_gpOrthosteric Ligandsst2_on_gp sst4_on_gp sst5_on_gp
23.33Single5UNHPubChem 1264564065UNH-AT2-PubChem 126456406
23.33Single6A93Risperidone6A93-5-HT2A-Risperidone
23.33Single6OS0Angiotensinogen6OS0-AT1-Angiotensinogen
23.33Single7EO4BAF3127EO4-S1P1-BAF312-Gi1/β1/γ2
23.33Single7XZ5Lysophosphatidylcholine7XZ5-GPR119-Lysophosphatidylcholine-Gs/β1/γ2
23.33Single8FYE4-F,5-MeO-PyrT8FYE-5-HT1A-4-F,5-MeO-PyrT-Gi1/β1/γ1
23.33Single8IA8E7 peptide8IA8-C3aB-E7 peptide-Gi1/β1/γ2
23.33Single8IYWGSK2560738IYW-HCA2-GSK256073-Go/β1/γ2
23.33Single8J6DEP1418J6D-C3aB-EP141-Go/β1/γ2
23.33Single8JD3HZR; PEF8JD3-mGlu2; mGlu3-Glutamate-HZR; PEF-Gi1/β1/γ2
23.33Single8JZ7MK68928JZ7-HCA2-MK6892-Gi1/β1/γ2
23.33Single9GYOP3959GYO-GPBA-P395-chim(NtGi1-Gs)/β1/γ2
23.33Consensuslpl_offOrthosteric Ligands1p_off lpa_off
23.33Consensusmop_onOrthosteric Ligand8F7R-μ-Endomorphin-Gi1/β1/γ2 8EF5-μ-Fentanyl-Gi1/β1/γ2 7SCG-μ-FH210-Gi1/β1/γ2 7T2H-μ-Lofentanil-Gi1/β1/γ2 7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2 8EF6-μ-Morphine-Gi1/β1/γ2 8EFB-μ-Oliceridine-Gi1/β1/γ2 7U2L-μ-PubChem 163201242-Gi1/β1/γ2 8EFO-μ-PZM21-Gi1/β1/γ2 8EFL-μ-SR17018-Gi1/β1/γ2 8F7Q-μ-β-Endorphin-Gi1/β1/γ2 7U2K-μ-C6-guano-Gi1/β1/γ2 8EFQ-μ-Damgo-Gi1/β1/γ2
23.33Consensusmop_on_gpOrthosteric Ligand8F7R-μ-Endomorphin-Gi1/β1/γ2 8EF5-μ-Fentanyl-Gi1/β1/γ2 7SCG-μ-FH210-Gi1/β1/γ2 7T2H-μ-Lofentanil-Gi1/β1/γ2 7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2 8EF6-μ-Morphine-Gi1/β1/γ2 8EFB-μ-Oliceridine-Gi1/β1/γ2 7U2L-μ-PubChem 163201242-Gi1/β1/γ2 8EFO-μ-PZM21-Gi1/β1/γ2 8EFL-μ-SR17018-Gi1/β1/γ2 8F7Q-μ-β-Endorphin-Gi1/β1/γ2 7U2K-μ-C6-guano-Gi1/β1/γ2 8EFQ-μ-Damgo-Gi1/β1/γ2
23.33Consensusopioid_offOrthosteric Ligandmop_off nop_off dop_off kop_off
23.08Single3V2WPubChem 518926453V2W-S1P1-PubChem 51892645
23.08Single5GLHEndothelin-15GLH-ETB-Endothelin-1
23.08Single6IGKEndothelin-36IGK-ETB-Endothelin-3
23.08Single7EJ0L-Norepinephrine7EJ0-α2a-L-Norepinephrine-Go/β1/γ2
23.08Single7LD4Adenosine7LD4-A1-Adenosine-Gi2/β1/γ2
23.08Single8IJBAcipimox8IJB-HCA2-Acipimox-Gi1/β1/γ2
23.08Single8J6LNiacin8J6L-HCA2-Niacin-Gi1/β1/γ2
23.08Single8Y0HVUF114188Y0H-CXCR3-VUF11418
23.08Consensusa1_onOrthosteric Ligand7LD4-A1-Adenosine-Gi2/β1/γ2
23.08Consensusa1_on_gpOrthosteric Ligand7LD4-A1-Adenosine-Gi2/β1/γ2
23.08Consensusccr5_on_gpOrthosteric Ligand7O7F-CCR5-6P4-CCL5-Gi1/β1/γ1 7F1Q-CCR5-MIP-1a-Gi1/β1/γ2
23.08Consensuss1p1_offOrthosteric Ligand3V2W-S1P1-PubChem 51892645
22.86Single6WIVPubChem 52923113; PubChem 529246456WIV-GABAB1, GABAB2-PubChem 52923113; PubChem 52924645
22.86Single7DW9AVP7DW9-V2-AVP-chim(NtGi1-Gs)/β1/γ2
22.86Single7F6GSAR1-AngII7F6G-AT1-SAR1-AngII-Gq/β1/γ2
22.86Single8H4KGW95088H4K-FFA4-GW9508-chim(NtGi1-Gs-CtGq)/β1/γ2
22.86Single8IHFMK68928IHF-HCA2-MK6892-Gi1/β1/γ2
22.86Single8WSTPro-MCH8WST-MCH2-Pro-MCH-chim(NtGi1L-Gs-CtGq)/β1/γ2
22.86Single8X8LCortistatin8X8L-SST5-Cortistatin-chim(NtGi1-Gs-CtGi1)/β1/γ2
22.86Single9BKKCholecystokinin-89BKK-CCKA-Cholecystokinin-8-chim(NtGi1-Gs-CtGq)/β1/γ2
22.86Consensusangiotensin_on_gpOrthosteric Ligandat1_on_gp
22.86Consensusapelin_onOrthosteric Ligand8XZH-Apelin-MM07-Gi1/β1/γ2 7W0M-Apelin-PubChem 122701908-Gi1/β1/γ2 8XZJ-Apelin-WN353-Gi1/β1/γ2 8XZF-Apelin-WN561-Gi1/β1/γ2 8XZG-Apelin-Apelin-13-Gi1/β1/γ2
22.86Consensusapelin_on_gpOrthosteric Ligand8XZH-Apelin-MM07-Gi1/β1/γ2 7W0M-Apelin-PubChem 122701908-Gi1/β1/γ2 8XZJ-Apelin-WN353-Gi1/β1/γ2 8XZF-Apelin-WN561-Gi1/β1/γ2 8XZG-Apelin-Apelin-13-Gi1/β1/γ2
22.86Consensusat1_on_gpOrthosteric Ligand7F6G-AT1-SAR1-AngII-Gq/β1/γ2
22.86Consensusgi_formylpeptideOrthosteric Ligand7WVY-FPR2-ALX-Amyloid-β42-Gi2/β1/γ2 7T6U-FPR2-ALX-CGEN-855A-Gi1/β1/γ2 7VFX-FPR1-ALX-fMLF-Gi1/β1/γ2 7T6V-FPR2-ALX-fMLFII-Gi1/β1/γ2 7WVX-FPR2-ALX-Humanin-Gi2/β1/γ2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/β1/γ2 6OMM-FPR2-ALX-WKYMVX-Gi1/β1/γ2
22.86Consensusgq_angiotensinOrthosteric Ligand7F6G-AT1-SAR1-AngII-Gq/β1/γ2
22.86Consensusgs_vasop-oxyOrthosteric Ligand7DW9-V2-AVP-chim(NtGi1-Gs)/β1/γ2
22.86Consensuspeptide_offon_gpOrthosteric Ligandpeptide_on_gp peptide_off
22.86Consensusprotein_offonOrthosteric Ligandprotein_off protein_on
22.86Consensusprotein_offon_gpOrthosteric Ligandprotein_on_gp protein_off
22.86Consensusv2_onOrthosteric Ligand7DW9-V2-AVP-chim(NtGi1-Gs)/β1/γ2
22.86Consensusv2_on_gpOrthosteric Ligand7DW9-V2-AVP-chim(NtGi1-Gs)/β1/γ2
22.86Consensusvasop-oxy_onOrthosteric Ligandv2_on
22.86Consensusvasop-oxy_on_gpOrthosteric Ligandv2_on_gp
22.58Single2YCZIodocyanopindolol2YCZ-β1-Iodocyanopindolol
22.58Single5CGDHTL142425CGD-mGlu5-HTL14242
22.58Single7EW0Ozanimod7EW0-S1P1-Ozanimod-Gi1/β1/γ2
22.58Single7EZCUKA7EZC-A2A-UKA
22.58Single7SK8CCX6627SK8-ACKR3-CXCL12-CCX662
22.58Single7X8RBOC57X8R-GLP-1-BOC5-Gs/β1/γ2
22.58Single7XJISolabegron7XJI-β3-Solabegron-Gs/β1/γ2
22.58Single7XK2MK68927XK2-HCA2-MK6892-Gi1/β1/γ2
22.58Single7Y65C5a peptide7Y65-C5a1-C5a peptide-Gi1/β1/γ2
22.58Single8J19LY2378J19-GPR84-LY237-Gi1/β1/γ2
22.58Single8XGSMetastin8XGS-Kiss1-Metastin-chim(NtGi1-Gq)/β1/γ2
22.58Single8XIOL7975918XIO-SST1-L797591-chim(NtGi1-Gs-CtGi1)/β1/γ2
22.58Consensusc3a_on_gpOrthosteric Ligand8HK2-C3aB-C3a anaphylatoxin-Gi1/β1/γ2 8IA8-C3aB-E7 peptide-Gi1/β1/γ2
22.22Single4ZUDOlmesartan4ZUD-AT1-Olmesartan
22.22Single6ZG9GSK10347026ZG9-M1-GSK1034702
22.22Single7F6HBradykinin7F6H-BK2-Bradykinin-Gq/β1/γ2
22.22Single7F6IKallidin7F6I-BK2-Kallidin-Gq/β1/γ2
22.22Single7QBIAlpha-factor mating pheromone7QBI-STE2-α-factor mating pheromone
22.22Single8HCQEndothelin-18HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/β1/γ2
22.22Single8HNKCXCL118HNK-CXCR3-CXCL11-Gi1/β1/γ2
22.22Single8HNMVUF112228HNM-CXCR3-VUF11222-Gi1/β1/γ2
22.22Single8IHKAcifran8IHK-HCA3-Acifran
22.22Single8JEI3-nitro-4-(propylamino)benzoic acid8JEI-HCAR3-3-nitro-4-(propylamino)benzoic acid-Gi1/β1/γ2
22.22Single8JERAcipimox8JER-HCA2-Acipimox-Go/β1/γ2
22.22Single8JLKUlotaront8JLK-TA1-Ulotaront-chim(NtGi1-Gs)/β1/γ2
22.22Single8JLNT1AM8JLN-TA1-T1AM-Gs/β1/γ2
22.22Single8PM2DMCH8PM2-TA7-DMCH-Gs/β1/γ2
22.22Single8UHBRO52563908UHB-TA1-RO5256390-Gs/β1/γ2
22.22Single8WC8ZH86518WC8-TA1-ZH8651-chim(NtGi1-Gs)/β1/γ2
22.22Single8XGOTAK4488XGO-Kiss1-TAK448-chim(NtGi1-Gq)/β1/γ2
22.22Single8XQEApelin-138XQE-Apelin-Apelin-13-Gi1/β1/γ2
22.22Single8XVHEndothelin-18XVH-ETB-Endothelin-1-chim(Gs-CtGq)/β1/γ2
22.22Single8ZRTET-18ZRT-ETB-ET-1
22.22Single9ASBCa; Ca; Cyclomethyltryptophan; 9IG; PO49ASB-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
22.22Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
22.22Consensusccr_on_gpOrthosteric Ligandccr6_on_gp ccr8_on_gp ccr2_on_gp ccr1_on_gp ccr5_on_gp
22.22Consensuschemokine_offOrthosteric Ligandccr_off cxcr_off
22.22Consensuschemokine_on_gpOrthosteric Ligandccr_on_gp cxcr_on_gp
22.22Consensuseta_onOrthosteric Ligand8HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/β1/γ2
22.22Consensuseta_on_gpOrthosteric Ligand8HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/β1/γ2
22.22Consensusgi_chemokineOrthosteric Ligand6WWZ-CCR6-CCL20-Go/β1/γ2 8HNK-CXCR3-CXCL11-Gi1/β1/γ2 8K3Z-CXCR4-CXCL12-Gi1/β1/γ1 8IC0-CXCR1-Interleukin-8-Gi1/β1/γ2 6LFM-CXCR2-Interleukin-8-Gi1/β1/γ2 8KFX-CCR8-LMD-009-Gi1/β1/γ2 7F1Q-CCR5-MIP-1a-Gi1/β1/γ2 8HNL-CXCR3-PS372424-Gi1/β1/γ2 8KFY-CCR8-ZK-756326-Gi1/β1/γ2 7O7F-CCR5-6P4-CCL5-Gi1/β1/γ1 8U1U-CCR8-CCL1-Gi1/β1/γ2 7VLA-CCR1-CCL15(27-92)-Gi1/β1/γ2 7XA3-CCR2-CCL2-Gi1/β1/γ2
22.22Consensusopioid_onOrthosteric Ligandmop_on nop_on dop_on kop_on
21.95Single6LRYSarafotoxin-B6LRY-ETB-Sarafotoxin-B
21.95Single7V35Peptide-207V35-Glucagon-Peptide-20-Gs/β1/γ2
21.95Single8JIPMEDI03828JIP-GLP-1-MEDI0382-chim(NtGi1-Gs)/β1/γ2
21.88Single5EE7MK08935EE7-Glucagon-MK0893
21.88Single5WF6UK-4320975WF6-A2A-UK-432097
21.88Single6XBJCholesterol6XBJ-SMO-Cholesterol-Gi1/β1/γ2
21.88Single7F2OBradykinin7F2O-BK2-Bradykinin-chim(NtGi1-Gs-CtGq)/β1/γ2
21.88Single7SK9CCX6627SK9-ACKR3-CCX662
21.88Single7X8SWB4-247X8S-GLP-1-WB4-24-Gs/β1/γ2
21.88Single7XY6BAY 60-65837XY6-A2B-BAY 60-6583-chim(NtGi1-Gs)/β1/γ2
21.88Single8IA7Cholecystokinin-88IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/β1/γ2
21.88Single8JLRA776368JLR-TA1-A77636-chim(NtGi1-Gs)/β1/γ2
21.88Single8X5YAstemizole8X5Y-H1-Astemizole
21.62Single5UIW5P7-CCL55UIW-CCR5-5P7-CCL5
21.62Single7F8VGastrin-177F8V-CCKB-Gastrin-17-Gi2/β1/γ2
21.62Single7QBIAlpha-factor mating pheromone7QBI-STE2-α-factor mating pheromone
21.62Single7W3ZGastrin Releasing Peptide7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/β1/γ2
21.62Single7YKDChemerin-97YKD-CML1-Chemerin-9-Gi1/β1/γ2
21.62Consensusccr5_offOrthosteric Ligand5UIW-CCR5-5P7-CCL5
21.62Consensusccr5_onOrthosteric Ligand7O7F-CCR5-6P4-CCL5-Gi1/β1/γ1 7F1Q-CCR5-MIP-1a-Gi1/β1/γ2
21.62Consensusgi_compl-peptOrthosteric Ligand8HK5-C5a1-Complement C5-Gi1/β1/γ2 8IA8-C3aB-E7 peptide-Gi1/β1/γ2 7Y66-C5a1-BM213-Gi1/β1/γ2 7Y67-C5a1-C089 peptide-Gi1/β1/γ2 8HK2-C3aB-C3a anaphylatoxin-Gi1/β1/γ2 7Y64-C5a1-C5a anaphylatoxin-Gi1/β1/γ2
21.62Consensusopioid_on_gpOrthosteric Ligandmop_on_gp nop_on_gp dop_on_gp kop_on_gp
21.43Single3NY8ICI118-5513NY8-β2-ICI118-551
21.43Single3NYAS-Alprenolol3NYA-β2-S-Alprenolol
21.43Single4GBRS-Carazolol4GBR-β2-S-Carazolol
21.43Single4U16N-Methyl-Scopolamine4U16-M3-N-Methyl-Scopolamine
21.43Single4X1HNonyl-Beta-D-Glucopyranoside4X1H-Rhodopsin-Nonyl-β-D-Glucopyranoside-Gt(CT)
21.43Single5TGZAM65385TGZ-CB1-AM6538
21.43Single7CFMP3957CFM-GPBA-P395-Gs/β1/γ2
21.43Single7UL4Alvimopan7UL4-μ-Alvimopan
21.43Single7VIES1P7VIE-S1P1-S1P-Gi1/β1/γ2
21.43Single7WC8Lumateperone7WC8-5-HT2A-Lumateperone
21.43Single7YACPaltusotine7YAC-SST2-Paltusotine-Gi1/β1/γ2
21.43Single7YK7DC5910537YK7-RXFP4-DC591053-Gi2/β1/γ2
21.43Single8CU7LJ-45178CU7-A2A-LJ-4517-Na
21.43Single8IHJAcifran8IHJ-HCA3-Acifran-Gi1/β1/γ2
21.43Single8JJOAlprenolol8JJO-β2-Alprenolol
21.43Single8W87METH8W87-TA1-METH-chim(NtGi1L-Gs)/β1/γ2
21.43Single9AVGCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVG-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs)/β1/γ2
21.43Single9CHXS-Carazolol9CHX-β2-S-Carazolol
21.43Single9IVGGLP-1 (Truncated)9IVG-GLP-1-GLP-1 (Truncated)-chim(NtGi1-Gs)/β1/γ2
21.43Consensusadenosine_on_gpOrthosteric Liganda1_on_gp a2_on_gp a3_on_gp
21.43Consensusdopamine_offOrthosteric Ligandd2_off d3_off
21.43Consensusgs_trace-amineOrthosteric Ligand8W88-TA1-SEP-363856-Gs/β1/γ2 8JLJ-TA1-T1AM-chim(NtGi1-Gs)/β1/γ2 8JLO-TA1-Ulotaront-Gs/β1/γ2 8WC4-TA1-ZH8651-chim(NtGi1-Gs)/β1/γ2 8WC7-TA1-ZH8667-chim(NtGi1-Gs)/β1/γ2 8JLR-TA1-A77636-chim(NtGi1-Gs)/β1/γ2 8JSO-TA1-AMPH-chim(NtGi1-Gs)/β1/γ2 8W87-TA1-METH-chim(NtGi1L-Gs)/β1/γ2 8W89-TA1-PEA-chim(NtGi1L-Gs)/β1/γ2 8JLP-TA1-Ralmitaront-Gs/β1/γ2 8W8A-TA1-RO5256390-chim(NtGi1L-Gs)/β1/γ2
21.21Single4XT1Fractalkine4XT1-US28-Fractalkine
21.21Single5UNFPubChem 157800525UNF-AT2-PubChem 15780052
21.21Single6X19CHU-1286X19-GLP-1-CHU-128-Gs/β1/γ2
21.21Single7QA8Peptide7QA8-STE2-Peptide
21.21Single7QA8Peptide7QA8-STE2-Peptide
21.21Single7T6UCGEN-855A7T6U-FPR2-ALX-CGEN-855A-Gi1/β1/γ2
21.21Single7XAUOctreotide7XAU-SST2-Octreotide-Gi1/β1/γ2
21.21Single8J6RMK68928J6R-HCA2-MK6892-Gi1/β1/γ2
21.21Single8PKMBefiradol8PKM-5-HT1A-Befiradol-t7m-Gi1/β1/γ1
21.21Single8WDTphotoNECA8WDT-A2A-photoNECA
21.21Single8ZSPLSD8ZSP-TA1-LSD-chim(NtGi1L-Gs-CtGq)/β1/γ2
21.21Single9L3YRetinoic acid receptor responder protein 29L3Y-CML2-Retinoic acid receptor responder protein 2-Gi1/β1/γ2
21.21Consensuschemokine_onOrthosteric Ligandccr_on cxcr_on
21.05Single7AD3Alpha-factor mating pheromone7AD3-STE2-α-factor mating pheromone-Gi1/STE4/γ2
21.05Single7QBCAlpha-factor mating pheromone7QBC-STE2-α-factor mating pheromone
21.05Single7XATSomatostatin-147XAT-SST2-Somatostatin-14-Gi1/β1/γ2
21.05Single7YOONeuropeptide-Y7YOO-Y2-Neuropeptide-Y-Gi1/β1/γ2
21.05Consensusnpy2_onOrthosteric Ligand7YOO-Y2-Neuropeptide-Y-Gi1/β1/γ2
21.05Consensusnpy2_on_gpOrthosteric Ligand7YOO-Y2-Neuropeptide-Y-Gi1/β1/γ2
20.83Single8GEIConstrained Epinephrine8GEI-β2-Constrained Epinephrine-Gs/β1/γ2
20.83Single8WC5Tetramethylammonium Ion8WC5-TA1-Tetramethylammonium Ion-chim(NtGi1-Gs)/β1/γ2
20.69Single2RH1S-Carazolol2RH1-β2-S-Carazolol
20.69Single2YCWS-Carazolol2YCW-β1-S-Carazolol
20.69Single4WW3All-trans-Retinal4WW3-Rhodopsin-All-trans-Retinal
20.69Single5C1MBU725C1M-μ-BU72
20.69Single5CGCHTL142425CGC-mGlu5-HTL14242
20.69Single5D6LS-Carazolol5D6L-β2-S-Carazolol
20.69Single5JQHS-Carazolol5JQH-β2-S-Carazolol
20.69Single5N2RPSB-365N2R-A2A-PSB-36-Na
20.69Single5N2SPSB365N2S-A1-PSB36
20.69Single5X7DS-Carazolol5X7D-β2-S-Carazolol-PubChem 129318963
20.69Single5ZK33-quinuclidinyl-benzilate5ZK3-M2-3-quinuclidinyl-benzilate
20.69Single6GDGNECA6GDG-A2A-NECA-Gs/β1/γ1
20.69Single6LUQHaloperidol6LUQ-D2-Haloperidol
20.69Single6ME72-Phenylmelatonin6ME7-MT2-2-Phenylmelatonin
20.69Single7BB7AVP7BB7-V2-AVP-Gs/β1/γ2
20.69Single7C4SS1P7C4S-S1P3-S1P
20.69Single7E9GJNJ-404118137E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/β1/γ2
20.69Single7LD3Adenosine7LD3-A1-Adenosine-PubChem 25263603-Gi2/β1/γ2
20.69Single7SINNPS-21437SIN-CaS-NPS-2143
20.69Single7SINNPS-21437SIN-CaS-NPS-2143
20.69Single7TD3S1P7TD3-S1P1-S1P-Gi1/β1/γ2
20.69Single7X1TTaltirelin7X1T-TRH-Taltirelin-chim(NtGi2L-Gs-CtGq)/β1/γ2
20.69Single8EFBOliceridine8EFB-μ-Oliceridine-Gi1/β1/γ2
20.69Single8HNLPS3724248HNL-CXCR3-PS372424-Gi1/β1/γ2
20.69Single8J18(3R)-3-Hydroxydodecanoic acid8J18-GPR84-(3R)-3-Hydroxydodecanoic acid-Gi1/β1/γ2
20.69Single8X0BVU04244658X0B-mGlu5; mGlu5-Quisqualate-VU0424465
20.69Single8X0CVU04244658X0C-mGlu5; mGlu5-Quisqualate-VU0424465
20.69Single8X0CVU04244658X0C-mGlu5; mGlu5-Quisqualate-VU0424465
20.69Single8X0DVU04244658X0D-mGlu5; mGlu5-Quisqualate-VU0424465
20.69Single8X0DVU04244658X0D-mGlu5; mGlu5-Quisqualate-VU0424465
20.69Single8XYKVUF106618XYK-CXCR3-VUF10661-Go1/β1/γ2
20.69Single8YH0NECA8YH0-A3A-NECA-Gi1/β1/γ2
20.69Single8YNSSNAP-948478YNS-MCH1-SNAP-94847
20.69Single8ZMFA1L108ZMF-5-HT2C-A1L10
20.69Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/β1/γ2
20.69Single9EAHOlmesartan9EAH-AT1-Olmesartan-Nanobody AT209
20.69Single9MQKIsoquinuclidine9MQK-κ-Isoquinuclidine
20.69Consensus5ht2_offOrthosteric Ligand5ht2a_off 5ht2b_off 5ht2c_off
20.69Consensusadenosine_offOrthosteric Liganda1_off a2_off
20.69Consensusamine_offOrthosteric Ligand5ht_off adrenergic_off dopamine_off histamine_off muscarinic_off
20.69Consensusamine_offonOrthosteric Ligandamine_off amine_on
20.69Consensusamine_offon_gpOrthosteric Ligandamine_on_gp amine_off
20.69Consensusamine_onOrthosteric Ligand5ht_on adrenergic_on dopamine_on histamine_on muscarinic_on trace-amine_on
20.69Consensusbeta2_offOrthosteric Ligand2RH1-β2-S-Carazolol 6PS3-β2-S-Carvedilol 6PS5-β2-S-Propranolol 3D4S-β2-Timolol 3NY8-β2-ICI118-551 3NY9-β2-ICI118-551 6PRZ-β2-S-Alprenolol
20.69Consensusbeta_offOrthosteric Ligandbeta1_off beta2_off
20.69Consensusblt1_offOrthosteric Ligand5X33-BLT1-BIIL260 7K15-BLT1-MKD046-Na
20.69Consensusblt_offOrthosteric Ligandblt1_off
20.69Consensusgi_adrenergicOrthosteric Ligand7EJ0-α2a-L-Norepinephrine-Go/β1/γ2 7EJK-α2a-Oxymetazoline-Go/β1/γ2 7W7E-α2a-PubChem 164946676-Go/β1/γ2 7W6P-α2a-N-pyridin-4-ylisoquinolin-4-amine-Go/β1/γ2 7EJ8-α2a-Brimonidine-Go/β1/γ2 6K42-α2b-Dexmedetomidine-Gi1/β1/γ2 7EJA-α2a-Dexmedetomidine-Go/β1/γ2 7S0F-β1-Isoprenaline-Gi1/β1/γ2
20.69Consensusgs_amineOrthosteric Ligandgs_5ht gs_adrenergic gs_dopamine gs_histamine gs_trace-amine
20.69Consensusm2_offOrthosteric Ligand5ZKC-M2-N-Methyl-Scopolamine 5ZK3-M2-3-quinuclidinyl-benzilate 5ZKB-M2-AF-DX 384
20.69Consensusrxfp4_onOrthosteric Ligand7YK7-RXFP4-DC591053-Gi2/β1/γ2 7YJ4-RXFP4-INSL5-Gi2/β1/γ2 7YK6-RXFP4-PubChem 138319674-Gi2/β1/γ2
20.69Consensusrxfp4_on_gpOrthosteric Ligand7YK7-RXFP4-DC591053-Gi2/β1/γ2 7YJ4-RXFP4-INSL5-Gi2/β1/γ2 7YK6-RXFP4-PubChem 138319674-Gi2/β1/γ2
20.69Consensuss1p5_offOrthosteric Ligand7YXA-S1P5-ONO-5430608
20.59Single5XJM(Sar1,Ile8)-Angiotensin II5XJM-AT2-(Sar1,Ile8)-Angiotensin II
20.59Single6HLOAprepitant6HLO-NK1-Aprepitant
20.59Single7E14Orforglipron7E14-GLP-1-Orforglipron-PubChem 156022738-Gs/β1/γ2
20.59Single7W0NElabela7W0N-Apelin-Elabela-Gi1/β1/γ2
20.59Single7XNACYN1548067XNA-SST2-CYN154806
20.59Single8F7QBeta-Endorphin8F7Q-μ-β-Endorphin-Gi1/β1/γ2
20.59Single8SG1Chemerin-98SG1-CML1-Chemerin-9-Gi1/β1/γ2
20.59Single8WSSPro-MCH8WSS-MCH1-Pro-MCH-Gi1/β1/γ1
20.59Consensusgi_cckOrthosteric Ligand7EZH-CCKA-Cholecystokinin-8-Gi1/β1/γ2 7F8V-CCKB-Gastrin-17-Gi2/β1/γ2
20.59Consensussst2_offOrthosteric Ligand7XNA-SST2-CYN154806
20.51Single6IGLIRL16206IGL-ETB-IRL1620
20.51Single7QBCAlpha-factor mating pheromone7QBC-STE2-α-factor mating pheromone
20.51Consensusendothelin_onOrthosteric Ligandetb_on eta_on
20.00Single4DJHJDTic4DJH-κ-JDTic
20.00Single4OO9Mavoglurant4OO9-mGlu5-Mavoglurant
20.00Single4Z34ONO-97803074Z34-LPA1-ONO-9780307
20.00Single5D5AS-Carazolol5D5A-β2-S-Carazolol
20.00Single5D5BS-Carazolol5D5B-β2-S-Carazolol
20.00Single5ZKBAF-DX 3845ZKB-M2-AF-DX 384
20.00Single6J21Aprepitant6J21-NK1-Aprepitant
20.00Single6O3CCholesterol6O3C-SMO-SAG21k-Cholesterol
20.00Single6PT2KGCHM076PT2-δ-KGCHM07
20.00Single6TQ7SB-3348676TQ7-OX1-SB-334867
20.00Single7CKYPW04647CKY-D1-PW0464-Gs/β1/γ2
20.00Single7EW4CYM55417EW4-S1P3-CYM5541-Gi1/β1/γ2
20.00Single7MT8All-trans-Retinal7MT8-Rhodopsin-All-trans-Retinal-GRK1
20.00Single7MT9All-trans-Retinal7MT9-Rhodopsin-All-trans-Retinal-GRK1
20.00Single7MTAAll-trans-Retinal7MTA-Rhodopsin-All-trans-Retinal-GRK1
20.00Single7O7F6P4-CCL57O7F-CCR5-6P4-CCL5-Gi1/β1/γ1
20.00Single7P2L4YI7P2L-mGlu5-4YI
20.00Single7PX4PSB-21137PX4-A2A-PSB-2113
20.00Single7T2HLofentanil7T2H-μ-Lofentanil-Gi1/β1/γ2
20.00Single7TD0LPA7TD0-LPA1-LPA-Gi1/β1/γ2
20.00Single7TD2LPA7TD2-LPA1-LPA-Gi1/β1/γ2
20.00Single7TRQIperoxo7TRQ-M4-Iperoxo-VU0467154-Gi1/β1/γ2
20.00Single7U2LPubChem 1632012427U2L-μ-PubChem 163201242-Gi1/β1/γ2
20.00Single7VIGCBP-3077VIG-S1P1-CBP-307-Gi1/β1/γ2
20.00Single7W6PN-pyridin-4-ylisoquinolin-4-amine7W6P-α2a-N-pyridin-4-ylisoquinolin-4-amine-Go/β1/γ2
20.00Single7W7EPubChem 1649466767W7E-α2a-PubChem 164946676-Go/β1/γ2
20.00Single7XTQR3997XTQ-GPBA-R399-Gs/β1/γ2
20.00Single8DZPmomSalB8DZP-κ-momSalB-Gi1/β1/γ2
20.00Single8E0GBU728E0G-μ-BU72
20.00Single8EF5Fentanyl8EF5-μ-Fentanyl-Gi1/β1/γ2
20.00Single8IRRRotigotine8IRR-D1-Rotigotine-Gs/β1/γ2
20.00Single8IRURotigotine8IRU-D4-Rotigotine-chim(NtGi1-Gs-CtGi1)/β1/γ2
20.00Single8IRVRotigotine8IRV-D5-Rotigotine-chim(NtGi1-Gs)/β1/γ2
20.00Single8IU2Retinal8IU2-Opsin1LW-Retinal-Gi1/β1/γ2
20.00Single8IYHMK68928IYH-HCA2-MK6892-Go/β1/γ2
20.00Single8JD5BQI; HZE; PEF8JD5-mGlu2; mGlu4-Glutamate-BQI; HZE; PEF-Gi1/β1/γ2
20.00Single8JEF(3S)-3-hydroxyoctanoic acid8JEF-HCA3-(3S)-3-hydroxyoctanoic acid-Gi1/β1/γ2
20.00Single8JXXClobenpropit8JXX-H4-Clobenpropit-Gi1/β1/γ2
20.00Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/β1/γ2
20.00Single8TAOCDPPB8TAO-mGlu5; mGlu5-Quisqualate-CDPPB
20.00Single8X0BVU04244658X0B-mGlu5; mGlu5-Quisqualate-VU0424465
20.00Single8X0FVU04244658X0F-mGlu5; mGlu5-Quisqualate-VU0424465
20.00Single8X16Piclidenoson8X16-A3A-Piclidenoson-Gi1/β1/γ2
20.00Single8XGUTAK4488XGU-Kiss1-TAK448-Gi1/β1/γ2
20.00Single8XIPPasireotide8XIP-SST1-Pasireotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
20.00Single8XIQL7967788XIQ-SST3-L796778-chim(NtGi1-Gs-CtGi1)/β1/γ2
20.00Single8XIRPasireotide8XIR-SST3-Pasireotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
20.00Single8XJMLatanoprost8XJM-FP-alpha-Latanoprost-chim(NtGi2-Gs-CtGq)/β1/γ2
20.00Single8YH6Namodenoson8YH6-A3A-Namodenoson-Gi1/β1/γ2
20.00Single9ASTLymphotactin9AST-XCR1-Lymphotactin-Gi1/β1/γ2
20.00Single9C1PCa; Tryptophan; '6218; PO49C1P-CaS-Ca-Ca; Tryptophan; '6218; PO4
20.00Single9F33FOB02-04A9F33-D3-FOB02-04A-Go1/β1/γ2
20.00Consensusa2_onOrthosteric Liganda2b_on
20.00Consensusa2_on_gpOrthosteric Liganda2b_on_gp
20.00Consensusa2b_onOrthosteric Ligand8HDP-A2B-Adenosine-Gs/β1/γ2 7XY6-A2B-BAY 60-6583-chim(NtGi1-Gs)/β1/γ2 7XY7-A2B-NECA-chim(NtGi1-Gs)/β1/γ2 8HDO-A2B-BAY 60-6583-Gs/β1/γ2
20.00Consensusa2b_on_gpOrthosteric Ligand8HDP-A2B-Adenosine-Gs/β1/γ2 7XY6-A2B-BAY 60-6583-chim(NtGi1-Gs)/β1/γ2 7XY7-A2B-NECA-chim(NtGi1-Gs)/β1/γ2 8HDO-A2B-BAY 60-6583-Gs/β1/γ2
20.00Consensusamine_on_gpOrthosteric Ligand5ht_on_gp adrenergic_on_gp dopamine_on_gp histamine_on_gp muscarinic_on_gp trace-amine_on_gp
20.00Consensusbeta1_offOrthosteric Ligand2VT4-β1-Cyanopindolol 2YCW-β1-S-Carazolol 2YCZ-β1-Iodocyanopindolol 5A8E-β1-7-Methylcyanopindolol-Na 3ZPQ-β1-4-(piperazin-1- yl)-1H-indole-Na 3ZPR-β1-4-methyl-2-(piperazin-1-yl)-Na
20.00Consensusd1_on_gpOrthosteric Ligand7F0T-D1-Dopamine-Gs/β1/γ2 7CKY-D1-PW0464-Gs/β1/γ2 8IRR-D1-Rotigotine-Gs/β1/γ2 7JV5-D1-SKF81297-Gs/β1/γ2 7JVP-D1-SKF83959-Gs/β1/γ2 7X2D-D1-Tavapadon-Gs/β1/γ2 7CKX-D1-A77636-Gs/β1/γ2 7JVQ-D1-Apomorphine-Gs/β1/γ2 7CKW-D1-Fenoldopam-Gs/β1/γ2
20.00Consensusd4_on_gpOrthosteric Ligand8IRU-D4-Rotigotine-chim(NtGi1-Gs-CtGi1)/β1/γ2
20.00Consensusd5_on_gpOrthosteric Ligand8IRV-D5-Rotigotine-chim(NtGi1-Gs)/β1/γ2
20.00Consensusfpr2-alx_onOrthosteric Ligand7WVX-FPR2-ALX-Humanin-Gi2/β1/γ2 7T6U-FPR2-ALX-CGEN-855A-Gi1/β1/γ2 7T6V-FPR2-ALX-fMLFII-Gi1/β1/γ2 7WVY-FPR2-ALX-Amyloid-β42-Gi2/β1/γ2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/β1/γ2 6OMM-FPR2-ALX-WKYMVX-Gi1/β1/γ2
20.00Consensusgi_npyOrthosteric Ligand8K6M-Y1-Neuropeptide-Y-Gi2/β1/γ1 7X9C-Y4-Pancreatic Hormone-Gi1/β1/γ2 7YOO-Y2-Neuropeptide-Y-Gi1/β1/γ2
20.00Consensusgi_opsinsOrthosteric Ligand8IU2-Opsin1LW-Retinal-Gi1/β1/γ2
20.00Consensusgi_sensoryOrthosteric Ligandgi_opsins
20.00Consensusgs_adenosineOrthosteric Ligand8HDP-A2B-Adenosine-Gs/β1/γ2 8HDO-A2B-BAY 60-6583-Gs/β1/γ2 7XY7-A2B-NECA-chim(NtGi1-Gs)/β1/γ2 7XY6-A2B-BAY 60-6583-chim(NtGi1-Gs)/β1/γ2
20.00Consensusgs_class-aOrthosteric Ligandgs_peptide gs_nucleotide gs_amine
20.00Consensusgs_dopamineOrthosteric Ligand7F0T-D1-Dopamine-Gs/β1/γ2 7CKW-D1-Fenoldopam-Gs/β1/γ2 7CKY-D1-PW0464-Gs/β1/γ2 8IRV-D5-Rotigotine-chim(NtGi1-Gs)/β1/γ2 8IRR-D1-Rotigotine-Gs/β1/γ2 7JV5-D1-SKF81297-Gs/β1/γ2 7JVP-D1-SKF83959-Gs/β1/γ2 7X2D-D1-Tavapadon-Gs/β1/γ2 7CKX-D1-A77636-Gs/β1/γ2 7JVQ-D1-Apomorphine-Gs/β1/γ2
20.00Consensusgs_nucleotideOrthosteric Ligandgs_adenosine
20.00Consensush4_on_gpOrthosteric Ligand8HN8-H4-Histamine-Gi1/β1/γ2 8HOC-H4-Imetit-Gi1/β1/γ2 8JXV-H4-Clozapine-Gi1/β1/γ2 8JXW-H4-VUF6884-Gi1/β1/γ2 8JXX-H4-Clobenpropit-Gi1/β1/γ2
20.00Consensuskop_offOrthosteric Ligand4DJH-κ-JDTic
20.00Consensusmuscarinic_offOrthosteric Ligandm2_off m3_off m4_off m5_off m1_off
20.00Consensusnpy_onOrthosteric Ligandnpy1_on npy2_on npy4_on
20.00Consensusnpy_on_gpOrthosteric Ligandnpy1_on_gp npy2_on_gp npy4_on_gp
20.00Consensusopsin1lw_onOrthosteric Ligand8IU2-Opsin1LW-Retinal-Gi1/β1/γ2
20.00Consensusopsin1lw_on_gpOrthosteric Ligand8IU2-Opsin1LW-Retinal-Gi1/β1/γ2
19.51Consensusendothelin_on_gpOrthosteric Ligandetb_on_gp eta_on_gp
19.44Single5WB2CX3CL1.355WB2-US28-CX3CL1.35
19.44Single6JODAngiotensin II6JOD-AT2-Angiotensin II
19.44Single7W40Bombesin7W40-BB2-Bombesin-chim(NtGi1L-Gq)/β1/γ2
19.44Single7YONPeptide-YY(3-36)7YON-Y2-Peptide-YY(3-36)-Gi1/β1/γ2
19.44Single8J6IMK68928J6I-HCA2-MK6892-Gi1/β1/γ2
19.44Single8XZJWN3538XZJ-Apelin-WN353-Gi1/β1/γ2
19.44Consensusfpr2-alx_on_gpOrthosteric Ligand7WVX-FPR2-ALX-Humanin-Gi2/β1/γ2 7T6U-FPR2-ALX-CGEN-855A-Gi1/β1/γ2 7T6V-FPR2-ALX-fMLFII-Gi1/β1/γ2 7WVY-FPR2-ALX-Amyloid-β42-Gi2/β1/γ2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/β1/γ2 6OMM-FPR2-ALX-WKYMVX-Gi1/β1/γ2
19.35Single3D4STimolol3D4S-β2-Timolol
19.35Single4AMIBucindolol4AMI-β1-Bucindolol
19.35Single4N4WSANT-14N4W-SMO-SANT-1
19.35Single4OR2FITM4OR2-mGlu1; mGlu1-FITM
19.35Single5CXVTiotropium5CXV-M1-Tiotropium
19.35Single6CM4Risperidone6CM4-D2-Risperidone
19.35Single6H7NS-Xamoterol6H7N-β1-S-Xamoterol
19.35Single6H7OCyanopindolol6H7O-β1-Cyanopindolol
19.35Single6OS2TRV0266OS2-AT1-TRV026
19.35Single6XBLCholesterol6XBL-SMO-SAG-Cholesterol-Gi1/β1/γ2
19.35Single6XOXOrforglipron6XOX-GLP-1-Orforglipron-chim(NtGi1-Gs)/β1/γ2
19.35Single6ZG4HTL00099366ZG4-M1-HTL0009936
19.35Single7BZ2Arformoterol7BZ2-β2-Arformoterol-Gs/β1/γ2
19.35Single7EPENAM5637EPE-mGlu2; mGlu2-NAM563
19.35Single7EW2Fingolimod7EW2-S1P3-Fingolimod-Gi1/β1/γ2
19.35Single7EXDLasmiditan7EXD-5-HT1F-Lasmiditan-Gi1/β1/γ2
19.35Single7JNIOlodanrigan7JNI-AT2-Olodanrigan
19.35Single7K15MKD0467K15-BLT1-MKD046-Na
19.35Single7T6BS1P7T6B-S1P2-S1P-chim(NtGi1L-G13)/β1/γ2
19.35Single7W0LPubChem 1227019087W0L-Apelin-PubChem 122701908-Gi1/β1/γ2
19.35Single7YITNalfurafine7YIT-κ-Nalfurafine
19.35Single8E9W2-Deoxycytidine8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/β1/γ2
19.35Single8FYTLSD8FYT-5-HT1A-LSD-Gi1/β1/γ1
19.35Single8G056-OAU8G05-GPR84-6-OAU-Gi1/β1/γ2
19.35Single8X8NOctreotide8X8N-SST5-Octreotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
19.35Single8XJNCloprosetnol8XJN-TP-Cloprosetnol-chim(NtGi1-Gs-CtGq)/β1/γ2
19.35Single8XQNCholesterol8XQN-TAS2R14-Cholesterol-Aristolochic acid A-Gi1/β1/γ1
19.35Single8XQSCholesterol8XQS-TAS2R14-Cholesterol-Flufenamic acid-Gi1/β1/γ1
19.35Single8XYIVUF106618XYI-CXCR3-VUF10661
19.35Single9MQLIsoquinuclidine9MQL-κ-Isoquinuclidine
19.35Consensus5ht1f_onOrthosteric Ligand7EXD-5-HT1F-Lasmiditan-Gi1/β1/γ2
19.35Consensus5ht1f_on_gpOrthosteric Ligand7EXD-5-HT1F-Lasmiditan-Gi1/β1/γ2
19.35Consensusbeta3_onOrthosteric Ligand7DH5-β3-Mirabegron-Gs/β1/γ2 7XJH-β3-Isoproterenol-Gs/β1/γ2 7XJI-β3-Solabegron-Gs/β1/γ2
19.35Consensusbeta3_on_gpOrthosteric Ligand7DH5-β3-Mirabegron-Gs/β1/γ2 7XJH-β3-Isoproterenol-Gs/β1/γ2 7XJI-β3-Solabegron-Gs/β1/γ2
19.35Consensusc3a_onOrthosteric Ligand8HK2-C3aB-C3a anaphylatoxin-Gi1/β1/γ2 8IA8-C3aB-E7 peptide-Gi1/β1/γ2
19.35Consensuscannabinoid_offOrthosteric Ligandcb2_off cb1_off
19.35Consensusleukotriene_offOrthosteric Ligandblt_off cyslt_off
19.35Consensuslpa1_offOrthosteric Ligand4Z36-LPA1-ONO-3080573 4Z35-LPA1-ONO-9910539 4Z34-LPA1-ONO-9780307
19.35Consensuslpa_offOrthosteric Ligandlpa1_off
19.35Consensusm1_offOrthosteric Ligand5CXV-M1-Tiotropium
19.35Consensuss1p3_onOrthosteric Ligand7EW3-S1P3-S1P-Gi1/β1/γ2 7EW4-S1P3-CYM5541-Gi1/β1/γ2 7EW2-S1P3-Fingolimod-Gi1/β1/γ2
19.23Single3AYMAll-trans-Retinal3AYM-Rhodopsin-All-trans-Retinal
19.23Single3OE9IT1t3OE9-CXCR4-IT1t
19.23Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
19.23Single7V68Iperoxo7V68-M4-Iperoxo-PubChem 57664406-Gi1/β1/γ2
19.23Single7YFDImetit7YFD-H4-Imetit-chim(NtGi1-Gs-CtGq)/β1/γ2
19.23Single8HN8Histamine8HN8-H4-Histamine-Gi1/β1/γ2
19.23Single8IHIAcifran8IHI-HCA2-Acifran-Gi1/β1/γ2
19.23Single8JILNiacin8JIL-HCA2-Niacin-Gi1/β1/γ2
19.23Single8W89PEA8W89-TA1-PEA-chim(NtGi1L-Gs)/β1/γ2
19.23Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/β1/γ2
19.23Single8Y0NVUF114188Y0N-CXCR3-VUF11418-Go1/β1/γ2
19.23Single8ZSVRO52633978ZSV-TA1-RO5263397-chim(NtGi1-Gs)/β1/γ2
19.23Single9EPRRetinal9EPR-Rhodopsin-Retinal-Gi1/β1/γ2
19.23Consensush4_onOrthosteric Ligand8HN8-H4-Histamine-Gi1/β1/γ2 8HOC-H4-Imetit-Gi1/β1/γ2 8JXV-H4-Clozapine-Gi1/β1/γ2 8JXW-H4-VUF6884-Gi1/β1/γ2 8JXX-H4-Clobenpropit-Gi1/β1/γ2
18.92Single7VL9CCL15(26-92)7VL9-CCR1-CCL15(26-92)-Gi1/β1/γ2
18.92Single7X9BNeuropeptide-Y7X9B-Y2-Neuropeptide-Y-Gi1/β1/γ2
18.92Single7Y64C5a anaphylatoxin7Y64-C5a1-C5a anaphylatoxin-Gi1/β1/γ2
18.92Single8IA2C5a anaphylatoxin8IA2-C5a1-C5a anaphylatoxin-Go/β1/γ2
18.92Single8ZPSPrRP208ZPS-PrRP-PrRP20-chim(NtGi1-Gs-CtGq)/β1/γ2
18.92Consensuscml1_on_gpOrthosteric Ligand7YKD-CML1-Chemerin-9-Gi1/β1/γ2
18.92Consensuscxcr_offOrthosteric Ligandcxcr3_off cxcr4_off
18.92Consensusmc1_onOrthosteric Ligand7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2 7F4D-MC1-α-MSH-chim(NtGi1-Gs)/β1/γ2 7F4I-MC1-SHU9119-chim(NtGi1-Gs)/β1/γ2
18.92Consensusmc1_on_gpOrthosteric Ligand7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2 7F4D-MC1-α-MSH-chim(NtGi1-Gs)/β1/γ2 7F4I-MC1-SHU9119-chim(NtGi1-Gs)/β1/γ2
18.75Single4OR2FITM4OR2-mGlu1; mGlu1-FITM
18.75Single4Z35ONO-99105394Z35-LPA1-ONO-9910539
18.75Single5UNGPubChem 157800525UNG-AT2-PubChem 15780052
18.75Single5X93K-87945X93-ETB-K-8794
18.75Single6M1HMaxadilan6M1H-PAC1-Maxadilan-Gs/β1/γ2
18.75Single7U2KC6-guano7U2K-μ-C6-guano-Gi1/β1/γ2
18.75Single7VGY2-Iodomelatonin7VGY-MT1-2-Iodomelatonin-Gi1/β1/γ2
18.75Single7X2DTavapadon7X2D-D1-Tavapadon-Gs/β1/γ2
18.75Single8E9X2-Deoxycytidine8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/β1/γ2
18.75Single8FX5Xanomeline8FX5-M4-Xanomeline-Xanomeline-Gi1/β1/γ2
18.75Single8IULLatanoprost8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/β1/γ2
18.75Single8XJKCloprosetnol8XJK-FP-alpha-Cloprosetnol-chim(NtGi1-Gs-CtGq)/β1/γ2
18.75Single8XJOU466198XJO-TP-U46619-chim(NtGi1-Gs-CtGq)/β1/γ2
18.75Consensuscck_onOrthosteric Ligandccka_on cckb_on
18.75Consensuscck_on_gpOrthosteric Ligandccka_on_gp cckb_on_gp
18.75Consensusendothelin_offOrthosteric Ligandetb_off
18.75Consensusetb_offOrthosteric Ligand5X93-ETB-K-8794 5XPR-ETB-Bosentan 6K1Q-ETB-IRL2500
18.75Consensuskop_on_gpOrthosteric Ligand8F7W-κ-Dynorphin-Gi1/β1/γ2 8DZS-κ-GR89,696-chim(NtGi2-Gz)/β1/γ2 8DZP-κ-momSalB-Gi1/β1/γ2
18.75Consensuspeptide_offOrthosteric Ligandcck_off angiotensin_off bombesin_off endothelin_off ghrelin_off npy_off opioid_off orexin_off somatostatin_off tachykinin_off vasop-oxy_off neurotensin_off
18.75Consensusprostanoid_offOrthosteric Ligandep_off dp_off
18.75Consensusprostanoid_onOrthosteric Ligandtp_on fp-alpha_on
18.75Consensusprostanoid_on_gpOrthosteric Ligandtp_on_gp fp-alpha_on_gp
18.75Consensustp_onOrthosteric Ligand8XJO-TP-U46619-chim(NtGi1-Gs-CtGq)/β1/γ2
18.75Consensustp_on_gpOrthosteric Ligand8XJO-TP-U46619-chim(NtGi1-Gs-CtGq)/β1/γ2
18.60Single7X9ANeuropeptide-Y7X9A-Y1-Neuropeptide-Y-Gi1/β1/γ2
18.52Single2Z7311-cis-Retinal2Z73-Rhodopsin-11-cis-Retinal
18.52Single3AYN9-cis-Retinal3AYN-Rhodopsin-9-cis-Retinal
18.52Single6B73MP11046B73-κ-MP1104
18.52Single6D9HAdenosine6D9H-A1-Adenosine-Gi2/β1/γ2
18.52Single6KUYPubChem 1457046436KUY-α2a-PubChem 145704643
18.52Single6OYAAll-trans-Retinal6OYA-Rhodopsin-All-trans-Retinal-Gt/β1/γ1
18.52Single7DHRIsoprenaline7DHR-β2-Isoprenaline-Gs/β1/γ2
18.52Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
18.52Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
18.52Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
18.52Single7T8XAcetylcholine7T8X-M2-Acetylcholine-chim(NtGi1-Go)/β1/γ2
18.52Single7T90Acetylcholine7T90-M2-Acetylcholine-chim(NtGi1-Go)/β1/γ2
18.52Single7T96Acetylcholine7T96-M2-Acetylcholine-LY2119620-Go/β1/γ2
18.52Single7W0OElabela7W0O-Apelin-Elabela-Gi1/β1/γ2
18.52Single7WF7S1P7WF7-S1P1-S1P-Gi1/β1/γ2
18.52Single7YM8Oxymetazoline7YM8-Alpha1A-Oxymetazoline-chim(Gs-CtGq)
18.52Single7YMHNorepinephrine7YMH-Alpha1A-Norepinephrine-chim(Gs-CtGq)
18.52Single8EFOPZM218EFO-μ-PZM21-Gi1/β1/γ2
18.52Single8GGAConstrained Epinephrine8GGA-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
18.52Single8GGCConstrained Epinephrine8GGC-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
18.52Single8GGRConstrained Epinephrine8GGR-β2-Constrained Epinephrine
18.52Single8GGWConstrained Epinephrine8GGW-β2-Constrained Epinephrine
18.52Single8GGZConstrained Epinephrine8GGZ-β2-Constrained Epinephrine
18.52Single8GH0Constrained Epinephrine8GH0-β2-Constrained Epinephrine
18.52Single8HDPAdenosine8HDP-A2B-Adenosine-Gs/β1/γ2
18.52Single8HMPC178HMP-GPR52-C17-Gs/β1/γ2
18.52Single8HOCImetit8HOC-H4-Imetit-Gi1/β1/γ2
18.52Single8IW4Spermidine8IW4-TA9-Spermidine-chim(NtGi1-Gs)/β1/γ2
18.52Single8IWESpermidine8IWE-TA9-Spermidine
18.52Single8JPPSuccinic acid8JPP-Succinate-Succinic acid-chim(Gs-CtGq)/β1/γ1
18.52Single8SZGCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-chim(NtGi1-Gq)/β1/γ2
18.52Single8UNXConstrained Epinephrine8UNX-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
18.52Single8UTDMK19038UTD-HCA2-MK1903-Gi1/β1/γ2
18.52Single8WC3SEP-3638568WC3-TA1-SEP-363856-chim(NtGi1-Gs)/β1/γ2
18.52Single8WC4ZH86518WC4-TA1-ZH8651-chim(NtGi1-Gs)/β1/γ2
18.52Single8WCA2-Phenylethylamine8WCA-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/β1/γ2
18.52Single8WOGSuccinic acid8WOG-Succinate-Succinic acid-Gi1/β1/γ2
18.52Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
18.52Single8YKXMaleic acid8YKX-Succinate-Maleic acid-Gi1/β1/γ1
18.52Single8YNAImmepip8YNA-H4-Immepip-Gi1/β1/γ
18.52Single9AVLCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVL-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi3/β2/γ2
18.52Single9C2FCa; Ca; Tryptophan; '6218; PO49C2F-CaS-Ca-Ca; Ca; Tryptophan; '6218; PO4
18.52Single9MQJIsoquinuclidine9MQJ-μ-Isoquinuclidine
18.52Consensusalpha2_offOrthosteric Ligandalpha2c_off
18.52Consensusangiotensin_offOrthosteric Ligandat1_off
18.52Consensusgi_succinateOrthosteric Ligand8YKW-Succinate-Succinic acid-Gi1/β1/γ1 8YKX-Succinate-Maleic acid-Gi1/β1/γ1
18.52Consensusm2_onOrthosteric Ligand7T8X-M2-Acetylcholine-chim(NtGi1-Go)/β1/γ2
18.52Consensusm2_on_gpOrthosteric Ligand7T8X-M2-Acetylcholine-chim(NtGi1-Go)/β1/γ2
18.52Consensusrhodopsin_on_gpOrthosteric Ligand6OYA-Rhodopsin-All-trans-Retinal-Gt/β1/γ1
18.52Consensussensory_offonOrthosteric Ligandsensory_off sensory_on
18.52Consensussensory_offon_gpOrthosteric Ligandsensory_on_gp sensory_on
18.52Consensussuccinate_onOrthosteric Ligand8YKW-Succinate-Succinic acid-Gi1/β1/γ1 8YKX-Succinate-Maleic acid-Gi1/β1/γ1
18.52Consensussuccinate_on_gpOrthosteric Ligand8YKW-Succinate-Succinic acid-Gi1/β1/γ1 8YKX-Succinate-Maleic acid-Gi1/β1/γ1
18.42Single4XT3Fractalkine4XT3-US28-Fractalkine
18.42Single7SK4CXCL12_LRHQ7SK4-ACKR3-CXCL12_LRHQ
18.42Single8H0PNMB308H0P-BB1-NMB30-chim(NtGi1-Gs-CtGq)/β1/γ2
18.18Single5VBLApelin mimetic peptide agonist5VBL-Apelin-Apelin mimetic peptide agonist
18.18Single5ZTYAM102575ZTY-CB2-AM10257
18.18Single7RKNFractalkine7RKN-US28-Fractalkine-Gi1/β1/γ2
18.18Single7T11Octreotide7T11-SST2-Octreotide-Gi3/β1/γ2
18.18Single7XBXCX3CL17XBX-CX3CR1-CX3CL1-Gi1/β1/γ2
18.18Single7XN9L-054,5227XN9-SST2-L-054,522
18.18Single7YAEOctreotide7YAE-SST2-Octreotide-Gi1/β1/γ2
18.18Single8QJ2pN1628QJ2-MC4-pN162-Gs
18.18Single8XQLCholesterol8XQL-TAS2R14-Cholesterol-Aristolochic acid A-Gt3/β1/γ1
18.18Single8XQOCholesterol8XQO-TAS2R14-Cholesterol-Aristolochic acid A-Gi1/β1/γ1
18.18Consensuscb2_offOrthosteric Ligand5ZTY-CB2-AM10257
18.18Consensuscxcr4_offOrthosteric Ligand4RWS-CXCR4-vMIP-II 3OE0-CXCR4-CVX15 3OE6-CXCR4-IT1t
18.18Consensuscxcr_on_gpOrthosteric Ligandcxcr3_on_gp cxcr4_on_gp cxcr1_on_gp cxcr2_on_gp
18.18Consensusformylpeptide_onOrthosteric Ligandfpr2-alx_on fpr1-alx_on
18.18Consensusgq_cckOrthosteric Ligand8IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/β1/γ2 7XOW-CCKB-Gastrin-chim(NtGi1-Gq)/β1/γ2 7EZM-CCKA-Cholecystokinin-8-chim(NtGsL-Gq)/β1/γ2 7F8W-CCKB-Gastrin-17-chim(NtGsL-Gq)/β1/γ2
18.18Consensusox2_onOrthosteric Ligand7L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/β1/γ2 7SQO-OX2-TAK-925-Gi1/β1/γ2 7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/β1/γ2
18.18Consensusox2_on_gpOrthosteric Ligand7L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/β1/γ2 7SQO-OX2-TAK-925-Gi1/β1/γ2 7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/β1/γ2
18.18Consensussst2_onOrthosteric Ligand7WIC-SST2-Somatostatin-14-Gi1/β1/γ2 7WIG-SST2-L-054,264-Gi1/β1/γ2 7YAE-SST2-Octreotide-Gi1/β1/γ2 7YAC-SST2-Paltusotine-Gi1/β1/γ2
18.18Consensussst2_on_gpOrthosteric Ligand7WIC-SST2-Somatostatin-14-Gi1/β1/γ2 7WIG-SST2-L-054,264-Gi1/β1/γ2 7YAE-SST2-Octreotide-Gi1/β1/γ2 7YAC-SST2-Paltusotine-Gi1/β1/γ2
17.95Single7F4FAfamelanotide7F4F-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2
17.95Single8FEG(DNCP)-Beta-Naloxamine8FEG-κ-(DNCP)-β-Naloxamine-Gi1/β1/γ2
17.95Single8XWPEndothelin-18XWP-ETB-Endothelin-1-Gi1/β1/γ2
17.95Single8ZJGChemerin8ZJG-CML1-Chemerin-Gi1/β1/γ2
17.95Single9K26PrRP319K26-PrRP-PrRP31-Gi1/β1/γ2
17.86Single1F8811-cis-Retinal1F88-Rhodopsin-11-cis-Retinal
17.86Single3UZC4-(3-amino-5-phenyl-1,2,4-triazin-6-yl)-2-chlorophenol3UZC-A2A-4-(3-amino-5-phenyl-1,2,4-triazin-6-yl)-2-chlorophenol
17.86Single3V2YPubChem 518926453V2Y-S1P1-PubChem 51892645
17.86Single4LDOL-Epinephrine4LDO-β2-L-Epinephrine
17.86Single4ZJCSB-6740424ZJC-OX1-SB-674042
17.86Single5IU7Q274563465IU7-A2A-Q27456346-Na
17.86Single5JTBZM-2413855JTB-A2A-ZM-241385
17.86Single5K2BZM-2413855K2B-A2A-ZM-241385-Na
17.86Single6FKAPubChem 1324730376FKA-Rhodopsin-PubChem 132473037
17.86Single6K41Dexmedetomidine6K41-α2b-Dexmedetomidine-Go/β1/γ2
17.86Single6ME32-Phenylmelatonin6ME3-MT1-2-Phenylmelatonin
17.86Single6PS0S-Carazolol6PS0-β2-S-Carazolol
17.86Single6PS4ICI118-5516PS4-β2-ICI118-551
17.86Single6PS82-Phenylmelatonin6PS8-MT1-2-Phenylmelatonin
17.86Single6TPGEMPA6TPG-OX2-EMPA
17.86Single6V9SGTPL114036V9S-OX1-GTPL11403
17.86Single6WH4Methiothepin6WH4-5-HT2A-Methiothepin
17.86Single6ZDRHMS1413f126ZDR-A2A-HMS1413f12-Na
17.86Single6ZFZ77-LH-28-16ZFZ-M1-77-LH-28-1
17.86Single7BB6AVP7BB6-V2-AVP-Gs/β1/γ2
17.86Single7DHISalbutamol7DHI-β2-Salbutamol-Gs/β1/γ2
17.86Single7EJADexmedetomidine7EJA-α2a-Dexmedetomidine-Go/β1/γ2
17.86Single7F61PF-036547467F61-H3-PF-03654746-Cholesterol
17.86Single7T32ZM-2413857T32-A2A-ZM-241385
17.86Single7T94Acetylcholine7T94-M2-Acetylcholine-PubChem 57664406-chim(NtGi1-Go)/β1/γ2
17.86Single7TRSAcetylcholine7TRS-M4-Acetylcholine-Gi1/β1/γ2
17.86Single7VUGJNJ-635330547VUG-GPR139-JNJ-63533054-Gi1/β1/γ2
17.86Single7WC9PubChem 1624213647WC9-5-HT2A-PubChem 162421364
17.86Single7YK6PubChem 1383196747YK6-RXFP4-PubChem 138319674-Gi2/β1/γ2
17.86Single8GE1Constrained Epinephrine8GE1-β2-Constrained Epinephrine-Gs/β1/γ2
17.86Single8GE4Constrained Epinephrine8GE4-β2-Constrained Epinephrine-Gs/β1/γ2
17.86Single8GE6Constrained Epinephrine8GE6-β2-Constrained Epinephrine-Gs/β1/γ2
17.86Single8GE7Constrained Epinephrine8GE7-β2-Constrained Epinephrine-Gs/β1/γ2
17.86Single8GE8Constrained Epinephrine8GE8-β2-Constrained Epinephrine-Gs/β1/γ2
17.86Single8GEAConstrained Epinephrine8GEA-β2-Constrained Epinephrine-Gs/β1/γ2
17.86Single8GEDConstrained Epinephrine8GED-β2-Constrained Epinephrine-Gs/β1/γ2
17.86Single8GEFConstrained Epinephrine8GEF-β2-Constrained Epinephrine-Gs/β1/γ2
17.86Single8GG8Constrained Epinephrine8GG8-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
17.86Single8GGQConstrained Epinephrine8GGQ-β2-Constrained Epinephrine
17.86Single8GGSConstrained Epinephrine8GGS-β2-Constrained Epinephrine
17.86Single8GGTConstrained Epinephrine8GGT-β2-Constrained Epinephrine
17.86Single8GGVConstrained Epinephrine8GGV-β2-Constrained Epinephrine
17.86Single8GGXConstrained Epinephrine8GGX-β2-Constrained Epinephrine
17.86Single8JLQFenoldopam8JLQ-TA1-Fenoldopam-Gs/β1/γ2
17.86Single8RQQZM-2413858RQQ-A2A-ZM-241385-Na
17.86Single8RWCStilSwitch28RWC-A2A-StilSwitch2-Na
17.86Single8RWDStilSwitch38RWD-A2A-StilSwitch3-Na
17.86Single8THKA616038THK-Alpha1A-A61603-chim(NtGi2L-Gs-CtGq)/β1/γ2
17.86Single8THLEpinephrine8THL-Alpha1A-Epinephrine-chim(NtGi2L-Gs-CtGq)/β1/γ2
17.86Single8UNMConstrained Epinephrine8UNM-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
17.86Single8UNWConstrained Epinephrine8UNW-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
17.86Single8UO0Constrained Epinephrine8UO0-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
17.86Single8W8BSEP-3638568W8B-5-HT1A-SEP-363856-Gi1/β1/γ2
17.86Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
17.86Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/β1/γ2
17.86Single8Y01Retinal8Y01-Opsin1MW-Retinal-Gi1/β1/γ2
17.86Single8YH2Adenosine8YH2-A3A-Adenosine-Gi1/β1/γ2
17.86Single9ASBCa; Ca; Cyclomethyltryptophan; 9IG; PO49ASB-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
17.86Single9AVGCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVG-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs)/β1/γ2
17.86Single9EPP11,20-Ethanoretinal9EPP-Rhodopsin-11,20-Ethanoretinal-chim(Gi1-CtGq)/β1/γ2
17.86Single9JKQMETH9JKQ-TA1-METH-Gs/β1/γ2
17.86Single9MQIIsoquinuclidine9MQI-μ-Isoquinuclidine
17.86Consensus5ht2a_offOrthosteric Ligand6A94-5-HT2A-Zotepine 6A93-5-HT2A-Risperidone 7VOD-5-HT2A-Cariprazine 7WC8-5-HT2A-Lumateperone 8JT8-5-HT2A-(R)-IHCH-7179
17.86Consensusa2_offOrthosteric Liganda2a_off
17.86Consensusa2a_offOrthosteric Ligand3RFM-A2A-Caffeine 8C9W-A2A-Etrumadenant 3UZA-A2A-GTPL9236 8GNG-A2A-Istradefylline 8CU6-A2A-LJ-4517 7PX4-A2A-PSB-2113 7PYR-A2A-PSB-2115 8DU3-A2A-PubChem 105526064 8JWY-A2A-2-118 8PWN-A2A-Theophylline 5IU4-A2A-ZM-241385-Na 5OLZ-A2A-PubChem 135566609-Na 6GT3-A2A-Imaradenant-Na 5OLV-A2A-LUAA41063-Na 5N2R-A2A-PSB-36-Na 5IU7-A2A-Q27456346-Na 5OLH-A2A-Vipadenant-Na 5OLO-A2A-Tozadenant-Na 6ZDR-A2A-HMS1413f12-Na 8GNE-A2A-KW-6356-Na 8JWZ-A2A-AB928-Na 5IU8-A2A-Q27456347-Na 5IUB-A2A-Q27456344-Na 6ZDV-A2A-Chromone 5d-Na 5IUA-A2A-Q27456348-Na 8A2P-A2A-LUAA47070-Na
17.86Consensusadenosine_onOrthosteric Liganda1_on a2_on a3_on
17.86Consensusalpha1_onOrthosteric Ligandalpha1a_on
17.86Consensusalpha1_on_gpOrthosteric Ligandalpha1a_on_gp
17.86Consensusalpha1a_onOrthosteric Ligand7EJ0-α2a-L-Norepinephrine-Go/β1/γ2 7EJ8-α2a-Brimonidine-Go/β1/γ2 7EJA-α2a-Dexmedetomidine-Go/β1/γ2 7EJK-α2a-Oxymetazoline-Go/β1/γ2 7W6P-α2a-N-pyridin-4-ylisoquinolin-4-amine-Go/β1/γ2 7W7E-α2a-PubChem 164946676-Go/β1/γ2
17.86Consensusalpha1a_on_gpOrthosteric Ligand7EJ0-α2a-L-Norepinephrine-Go/β1/γ2 7EJ8-α2a-Brimonidine-Go/β1/γ2 7EJA-α2a-Dexmedetomidine-Go/β1/γ2 7EJK-α2a-Oxymetazoline-Go/β1/γ2 7W6P-α2a-N-pyridin-4-ylisoquinolin-4-amine-Go/β1/γ2 7W7E-α2a-PubChem 164946676-Go/β1/γ2
17.86Consensusat1_offOrthosteric Ligand4YAY-AT1-ZD-7155 4ZUD-AT1-Olmesartan
17.86Consensusgi_adenosineOrthosteric Ligand7LD4-A1-Adenosine-Gi2/β1/γ2 8X17-A3A-Namodenoson-Gi1/β1/γ2 8X16-A3A-Piclidenoson-Gi1/β1/γ2
17.86Consensusgrh_offOrthosteric Ligandgnrh1_off
17.86Consensusopsins_offOrthosteric Ligandrhodopsin_off
17.86Consensussensory_offOrthosteric Ligandopsins_off
17.65Single4AMJS-Carvedilol4AMJ-β1-S-Carvedilol
17.65Single7F8XNN90567F8X-CCKA-NN9056
17.65Single7WICSomatostatin-147WIC-SST2-Somatostatin-14-Gi1/β1/γ2
17.65Single7XMRSomatostatin-147XMR-SST2-Somatostatin-14-Gi1/β1/γ2
17.65Single8DCRDobutamine8DCR-β1-Dobutamine-Gs/β1/γ2
17.65Single8FYLVilazodone8FYL-5-HT1A-Vilazodone-Gi1/β1/γ1
17.65Single8K3ZCXCL128K3Z-CXCR4-CXCL12-Gi1/β1/γ1
17.65Single8XGMChemerin8XGM-CML2-Chemerin-Gi1/β1/γ2
17.65Consensuschemerin_on_gpOrthosteric Ligandcml1_on_gp
17.65Consensuscml1_onOrthosteric Ligand7YKD-CML1-Chemerin-9-Gi1/β1/γ2
17.65Consensuscxcr4_onOrthosteric Ligand8K3Z-CXCR4-CXCL12-Gi1/β1/γ1
17.65Consensusgi_chemerinOrthosteric Ligand7YKD-CML1-Chemerin-9-Gi1/β1/γ2
17.65Consensuslpl_onOrthosteric Ligands1p_on lpa_on
17.65Consensuslpl_on_gpOrthosteric Ligands1p_on_gp lpa_on_gp
17.65Consensussomatostatin_offOrthosteric Ligandsst2_off
17.50Single7VGXNeuropeptide-Y7VGX-Y1-Neuropeptide-Y-Gi1/β1/γ2
17.50Single8IY6Endothelin-18IY6-ETB-Endothelin-1
17.50Single8Y52BA18Y52-BB3-BA1-chim(NtGi1-Gs-CtGq)/β1/γ2
17.39Single8GEJConstrained Epinephrine8GEJ-β2-Constrained Epinephrine-Gs/β1/γ2
17.24Single2Y04Salbutamol2Y04-β1-Salbutamol
17.24Single3EMLZM-2413853EML-A2A-ZM-241385
17.24Single3ZPQ4-(piperazin-1- yl)-1H-indole3ZPQ-β1-4-(piperazin-1- yl)-1H-indole-Na
17.24Single3ZPR4-methyl-2-(piperazin-1-yl)3ZPR-β1-4-methyl-2-(piperazin-1-yl)-Na
17.24Single4DAJTiotropium4DAJ-M3-Tiotropium
17.24Single4EA3PubChem 102965614EA3-NOP-PubChem 10296561
17.24Single4EIYZM-2413854EIY-A2A-ZM-241385-Na
17.24Single4EJ4Naltrindole4EJ4-δ-Naltrindole
17.24Single4J4QOctyl Beta-D-Glucopyranoside4J4Q-Rhodopsin-Octyl β-D-Glucopyranoside-Gt(CT)
17.24Single4QKX35V4QKX-β2-35V
17.24Single4YAYZD-71554YAY-AT1-ZD-7155
17.24Single5DHHSB-6121115DHH-NOP-SB-612111
17.24Single5DSGTiotropium5DSG-M4-Tiotropium
17.24Single5IU8Q274563475IU8-A2A-Q27456347-Na
17.24Single5K2AZM-2413855K2A-A2A-ZM-241385-Na
17.24Single5OLGZM-2413855OLG-A2A-ZM-241385-Na
17.24Single5VRAZM-2413855VRA-A2A-ZM-241385-Na
17.24Single5YC8N-Methyl-Scopolamine5YC8-M2-N-Methyl-Scopolamine
17.24Single5ZK8N-Methyl-Scopolamine5ZK8-M2-N-Methyl-Scopolamine
17.24Single5ZKCN-Methyl-Scopolamine5ZKC-M2-N-Methyl-Scopolamine
17.24Single6DRZMethysergide6DRZ-5-HT2B-Methysergide
17.24Single6FKDPubChem 1373491836FKD-Rhodopsin-PubChem 137349183
17.24Single6H7MSalbutamol6H7M-β1-Salbutamol
17.24Single6IIVDaltroban6IIV-TP-Daltroban
17.24Single6K42Dexmedetomidine6K42-α2b-Dexmedetomidine-Gi1/β1/γ2
17.24Single6PS1Timolol6PS1-β2-Timolol
17.24Single6PS2S-Alprenolol6PS2-β2-S-Alprenolol
17.24Single6S0LZM-2413856S0L-A2A-ZM-241385
17.24Single6TOTLemborexant6TOT-OX1-Lemborexant
17.24Single6WHADB139486WHA-5-HT2A-DB13948-chim(NtGi2L-Gs-CtGq)/β1/γ2
17.24Single6XBM25(S)-Epoxycholesterol6XBM-SMO-25(S)-Epoxycholesterol-Gi1/β1/γ2
17.24Single7BTSL-Epinephrine7BTS-β1-L-Epinephrine
17.24Single7BU6L-Norepinephrine7BU6-β1-L-Norepinephrine
17.24Single7CRHSKF839597CRH-D1-SKF83959-Gs/β1/γ2
17.24Single7DB6Ramelteon7DB6-MT1-Ramelteon-Gi1/β1/γ2
17.24Single7E32Serotonin7E32-5-HT1D-Serotonin-Gi1/β1/γ2
17.24Single7JVQApomorphine7JVQ-D1-Apomorphine-Gs/β1/γ2
17.24Single7M3JNPS-2143; PO47M3J-CaS-NPS-2143; PO4
17.24Single7PYRPSB-21157PYR-A2A-PSB-2115
17.24Single7S0GIsoprenaline7S0G-β1-Isoprenaline-chim(Gi1-CtGs)/β1/γ2
17.24Single7T2GMitragynine Pseudoindoxyl7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2
17.24Single7UM55-CT7UM5-5-HT5A-5-CT-chim(NtGi1-Go)/β1/γ2
17.24Single7VIFS-FTY720-P7VIF-S1P1-S-FTY720-P-Gi1/β1/γ2
17.24Single7VKTLTB47VKT-BLT1-LTB4-Gi1/β1/γ2
17.24Single7WC7Lisuride7WC7-5-HT2A-Lisuride
17.24Single7YXAONO-54306087YXA-S1P5-ONO-5430608
17.24Single8CU6LJ-45178CU6-A2A-LJ-4517
17.24Single8DZSGR89,6968DZS-κ-GR89,696-chim(NtGi2-Gz)/β1/γ2
17.24Single8FY85-MeO-DMT8FY8-5-HT1A-5-MeO-DMT-Gi1/β1/γ1
17.24Single8GE3Constrained Epinephrine8GE3-β2-Constrained Epinephrine-Gs/β1/γ2
17.24Single8GE9Constrained Epinephrine8GE9-β2-Constrained Epinephrine-Gs/β1/γ2
17.24Single8GECConstrained Epinephrine8GEC-β2-Constrained Epinephrine-Gs/β1/γ2
17.24Single8GEEConstrained Epinephrine8GEE-β2-Constrained Epinephrine-Gs/β1/γ2
17.24Single8GEHConstrained Epinephrine8GEH-β2-Constrained Epinephrine-Gs/β1/γ2
17.24Single8GFVConstrained Epinephrine8GFV-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
17.24Single8GFWConstrained Epinephrine8GFW-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
17.24Single8GFXConstrained Epinephrine8GFX-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
17.24Single8GFZConstrained Epinephrine8GFZ-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
17.24Single8GG0Constrained Epinephrine8GG0-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
17.24Single8GG1Constrained Epinephrine8GG1-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
17.24Single8GG3Constrained Epinephrine8GG3-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
17.24Single8GG4Constrained Epinephrine8GG4-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
17.24Single8GG6Constrained Epinephrine8GG6-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
17.24Single8GG9Constrained Epinephrine8GG9-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
17.24Single8GGIConstrained Epinephrine8GGI-β2-Constrained Epinephrine
17.24Single8GGJConstrained Epinephrine8GGJ-β2-Constrained Epinephrine
17.24Single8GGKConstrained Epinephrine8GGK-β2-Constrained Epinephrine
17.24Single8GGNConstrained Epinephrine8GGN-β2-Constrained Epinephrine
17.24Single8GGOConstrained Epinephrine8GGO-β2-Constrained Epinephrine
17.24Single8GGUConstrained Epinephrine8GGU-β2-Constrained Epinephrine
17.24Single8JD0NAM5638JD0-mGlu2; mGlu3-Glutamate-NAM563
17.24Single8JLJT1AM8JLJ-TA1-T1AM-chim(NtGi1-Gs)/β1/γ2
17.24Single8JLZST19368JLZ-5-HT6-ST1936-Gs/β1/γ2
17.24Single8JT8(R)-IHCH-71798JT8-5-HT2A-(R)-IHCH-7179
17.24Single8JXRLSD8JXR-D1-LSD
17.24Single8PJKST1718PJK-5-HT1A-ST171-t7m-Gi1/β1/γ1
17.24Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/β1/γ2
17.24Single8UH3Setiptiline8UH3-5-HT1E-Setiptiline-Gi1/β1/γ1
17.24Single8UNQConstrained Epinephrine8UNQ-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
17.24Single8UNRConstrained Epinephrine8UNR-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
17.24Single8UNUConstrained Epinephrine8UNU-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
17.24Single8UNVConstrained Epinephrine8UNV-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
17.24Single8UNYConstrained Epinephrine8UNY-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
17.24Single8UNZConstrained Epinephrine8UNZ-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
17.24Single8UO2Constrained Epinephrine8UO2-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
17.24Single8X17Namodenoson8X17-A3A-Namodenoson-Gi1/β1/γ2
17.24Single8X63Mepyramine8X63-H1-Mepyramine
17.24Single8X64Desloratadine8X64-H1-Desloratadine
17.24Single8XVKAmbrisentan8XVK-ETA-Ambrisentan
17.24Single8YICSAR2477998YIC-S1P1-SAR247799-Gi1/β1/γ2
17.24Single9CBMDexmedetomidine9CBM-α2a-Dexmedetomidine-Gi1/β1/γ2
17.24Single9D61JDTic9D61-κ-JDTic-Gi1/β1/γ2
17.24Consensus5ht1d_onOrthosteric Ligand7E32-5-HT1D-Serotonin-Gi1/β1/γ2
17.24Consensus5ht1d_on_gpOrthosteric Ligand7E32-5-HT1D-Serotonin-Gi1/β1/γ2
17.24Consensus5ht2b_offOrthosteric Ligand6DRZ-5-HT2B-Methysergide
17.24Consensusa3_onOrthosteric Liganda3a_on
17.24Consensusadrenergic_onOrthosteric Ligandalpha_on beta_on
17.24Consensusalpha2_onOrthosteric Ligandalpha2b_on
17.24Consensusalpha2_on_gpOrthosteric Ligandalpha2b_on_gp
17.24Consensusalpha2b_onOrthosteric Ligand6K42-α2b-Dexmedetomidine-Gi1/β1/γ2
17.24Consensusalpha2b_on_gpOrthosteric Ligand6K42-α2b-Dexmedetomidine-Gi1/β1/γ2
17.24Consensusalpha_onOrthosteric Ligandalpha1_on alpha2_on
17.24Consensusblt1_onOrthosteric Ligand7VKT-BLT1-LTB4-Gi1/β1/γ2
17.24Consensusblt1_on_gpOrthosteric Ligand7VKT-BLT1-LTB4-Gi1/β1/γ2
17.24Consensusblt_onOrthosteric Ligandblt1_on
17.24Consensusblt_on_gpOrthosteric Ligandblt1_on_gp
17.24Consensusd5_onOrthosteric Ligand8IRV-D5-Rotigotine-chim(NtGi1-Gs)/β1/γ2
17.24Consensusdop_offOrthosteric Ligand4EJ4-δ-Naltrindole
17.24Consensusdopamine_onOrthosteric Ligandd2_on d1_on d3_on d4_on d5_on
17.24Consensusdopamine_on_gpOrthosteric Ligandd2_on_gp d1_on_gp d3_on_gp d4_on_gp d5_on_gp
17.24Consensusgi_histamineOrthosteric Ligand8JXX-H4-Clobenpropit-Gi1/β1/γ2 8JXV-H4-Clozapine-Gi1/β1/γ2 8YUU-H3-Histamine-Gi1/β1/γ1 8HN8-H4-Histamine-Gi1/β1/γ2 8HOC-H4-Imetit-Gi1/β1/γ2 8JXW-H4-VUF6884-Gi1/β1/γ2
17.24Consensusgi_leukotrieneOrthosteric Ligand7VKT-BLT1-LTB4-Gi1/β1/γ2
17.24Consensusgq_amineOrthosteric Ligandgq_muscarinic gq_histamine
17.24Consensushistamine_offOrthosteric Ligandh1_off
17.24Consensusleukotriene_onOrthosteric Ligandblt_on
17.24Consensusleukotriene_on_gpOrthosteric Ligandblt_on_gp
17.24Consensuslipid_offOrthosteric Ligandcannabinoid_off paf_off lpl_off prostanoid_off leukotriene_off
17.24Consensusm4_offOrthosteric Ligand5DSG-M4-Tiotropium
17.24Consensusmuscarinic_onOrthosteric Ligandm2_on m3_on m4_on m1_on
17.24Consensusmuscarinic_on_gpOrthosteric Ligandm2_on_gp m3_on_gp m4_on_gp m1_on_gp
17.14Single7C6A(Sar1,Ile8)-Angiotensin II7C6A-AT2-(Sar1,Ile8)-Angiotensin II
17.14Single7EZKCholecystokinin-87EZK-CCKA-Cholecystokinin-8-chim(NtGi1-Gs)/β1/γ2
17.14Single7F1QMIP-1a7F1Q-CCR5-MIP-1a-Gi1/β1/γ2
17.14Single7SK5CXCL127SK5-ACKR3-CXCL12
17.14Single7WJ5Somatostatin-147WJ5-SST2-Somatostatin-14-Gi1/β1/γ2
17.14Consensuscckb_onOrthosteric Ligand8IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/β1/γ2 7XOW-CCKB-Gastrin-chim(NtGi1-Gq)/β1/γ2 7F8V-CCKB-Gastrin-17-Gi2/β1/γ2
17.07Consensusgi_endothelinOrthosteric Ligand8IY5-ETB-Endothelin-1-Gi1/β1/γ2 8HBD-ETB-IRL1620-Gi1/β1/γ2
16.67Single2Y03Isoprenaline2Y03-β1-Isoprenaline
16.67Single4ZJ8Suvorexant4ZJ8-OX1-Suvorexant
16.67Single5IUAQ274563485IUA-A2A-Q27456348-Na
16.67Single5NM2ZM-2413855NM2-A2A-ZM-241385-Na
16.67Single5TVNLSD5TVN-5-HT2B-LSD
16.67Single5WIUNemonapride5WIU-D4-Nemonapride
16.67Single5WIVNemonapride5WIV-D4-Nemonapride-Na
16.67Single5WQCEMPA5WQC-OX2-EMPA
16.67Single5YHLPubChem 1351213525YHL-EP4-PubChem 135121352
16.67Single5YWYONO-AE3-2085YWY-EP4-ONO-AE3-208
16.67Single6D26Fevipiprant6D26-DP2-Fevipiprant
16.67Single6KUWPubChem 572132346KUW-α2c-PubChem 57213234
16.67Single6LPLZM-2413856LPL-A2A-ZM-241385-Na
16.67Single6ME62-Phenylmelatonin6ME6-MT2-2-Phenylmelatonin
16.67Single6ME82-Phenylmelatonin6ME8-MT2-2-Phenylmelatonin
16.67Single6MEOEnvelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd46MEO-CCR5-Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4
16.67Single6OIKIperoxo6OIK-M2-Iperoxo-LY2119620-chim(NtGi1-Go)/β1/γ2
16.67Single6PS3S-Carvedilol6PS3-β2-S-Carvedilol
16.67Single6S0QZM-2413856S0Q-A2A-ZM-241385
16.67Single6TO7Suvorexant6TO7-OX1-Suvorexant-Na
16.67Single6TP6Filorexant6TP6-OX1-Filorexant
16.67Single6W2XPubChem 237279706W2X-GABAB1, GABAB2-PubChem 5311042-PubChem 23727970
16.67Single6W2XPubChem 237279706W2X-GABAB1, GABAB2-PubChem 5311042-PubChem 23727970
16.67Single6WQAZM-2413856WQA-A2A-ZM-241385-Na
16.67Single6XBKCholesterol6XBK-SMO-Cholesterol-Gi1/β1/γ2
16.67Single7BVQS-Carazolol7BVQ-β1-S-Carazolol
16.67Single7C61Ergotamine7C61-5-HT1B-Ergotamine
16.67Single7CFNINT-7777CFN-GPBA-INT-777-Gs/β1/γ2
16.67Single7M3JNPS-2143; PO47M3J-CaS-NPS-2143; PO4
16.67Single7RM5ZM-2413857RM5-A2A-ZM-241385-Na
16.67Single7RYCOxytocin7RYC-OT-Oxytocin-chim(NtGi2L-Gs-CtGq)/β1/γ2
16.67Single7S0FIsoprenaline7S0F-β1-Isoprenaline-Gi1/β1/γ2
16.67Single7SBFPZM217SBF-μ-PZM21-Gi1/β1/γ2
16.67Single7TRKIperoxo7TRK-M4-Iperoxo-Gi1/β1/γ2
16.67Single7VOEAripiprazole7VOE-5-HT2A-Aripiprazole
16.67Single7VUHJNJ-635330547VUH-GPR139-JNJ-63533054-chim(Gs-CtGq)/β1/γ2
16.67Single7W41PD1762527W41-BB2-PD176252
16.67Single7XK9Constrained Isoproterenol7XK9-β2-Constrained Isoproterenol-Na
16.67Single7XKAConstrained Epinephrine7XKA-β2-Constrained Epinephrine
16.67Single7YU6ONO-07405567YU6-LPA1-ONO-0740556-Gi1/β1/γ2
16.67Single8C9WEtrumadenant8C9W-A2A-Etrumadenant
16.67Single8DZQmomSalB8DZQ-κ-momSalB-Go/β1/γ2
16.67Single8DZRGR89,6968DZR-κ-GR89,696-chim(NtGi2-Gt3)/β1/γ2
16.67Single8FYNZM-2413858FYN-A2A-ZM-241385-Na
16.67Single8GD9Rivenprost8GD9-EP4-Rivenprost-Gs/β1/γ2
16.67Single8GDCPGE28GDC-EP3-PGE2-Gi1/β1/γ2
16.67Single8GDZConstrained Epinephrine8GDZ-β2-Constrained Epinephrine-Gs/β1/γ2
16.67Single8GEBConstrained Epinephrine8GEB-β2-Constrained Epinephrine-Gs/β1/γ2
16.67Single8GEGConstrained Epinephrine8GEG-β2-Constrained Epinephrine-Gs/β1/γ2
16.67Single8GFYConstrained Epinephrine8GFY-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
16.67Single8GG2Constrained Epinephrine8GG2-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
16.67Single8GGBConstrained Epinephrine8GGB-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
16.67Single8GNEKW-63568GNE-A2A-KW-6356-Na
16.67Single8K6NPro-neuropeptide-Y8K6N-Y2-Pro-neuropeptide-Y-Gi2/β1/γ1
16.67Single8QOTNanobody-E8QOT-μ-Nanobody-E
16.67Single8S4DCMF-0198S4D-Apelin-CMF-019
16.67Single8SZGCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-chim(NtGi1-Gq)/β1/γ2
16.67Single8SZICa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZI-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi3/β1/γ2
16.67Single8T6JCDPPB8T6J-mGlu5; mGlu5-CDPPB
16.67Single8T6JCDPPB8T6J-mGlu5; mGlu5-CDPPB
16.67Single8TH4Losartan8TH4-AT1-Losartan-AT118-L Nanobody
16.67Single8UNNConstrained Epinephrine8UNN-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
16.67Single8UNPConstrained Epinephrine8UNP-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
16.67Single8WGBW9R8WGB-mGlu4; mGlu2-Glutammate-W9R-Gi3/β1/γ2
16.67Single8XZGApelin-138XZG-Apelin-Apelin-13-Gi1/β1/γ2
16.67Single8XZHMM078XZH-Apelin-MM07-Gi1/β1/γ2
16.67Single9B54A1AIW9B54-CB1-A1AIW-Gi1/β1/γ2
16.67Single9F34FOB02-04A9F34-D3-FOB02-04A-Go1/β1/γ2
16.67Consensus5ht1_onOrthosteric Ligand5ht1a_on 5ht1d_on 5ht1e_on 5ht1f_on
16.67Consensus5ht1_on_gpOrthosteric Ligand5ht1a_on_gp 5ht1d_on_gp 5ht1e_on_gp 5ht1f_on_gp
16.67Consensus5ht1e_on_gpOrthosteric Ligand7E33-5-HT1E-BRL-54443-Gi1/β1/γ2 8UGY-5-HT1E-Mianserin-Gi1/β1/γ1 8UH3-5-HT1E-Setiptiline-Gi1/β1/γ1
16.67Consensus5ht5_on_gpOrthosteric Ligand5ht5a_on_gp
16.67Consensus5ht5a_on_gpOrthosteric Ligand7X5H-5-HT5A-5-CT-Gi1/β1/γ2 7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/β1/γ2 7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/β1/γ2
16.67Consensusa1_offOrthosteric Ligand5UEN-A1-DU172 5N2S-A1-PSB36
16.67Consensusa3_on_gpOrthosteric Liganda3a_on_gp
16.67Consensusa3a_onOrthosteric Ligand8X17-A3A-Namodenoson-Gi1/β1/γ2 8X16-A3A-Piclidenoson-Gi1/β1/γ2
16.67Consensusa3a_on_gpOrthosteric Ligand8X17-A3A-Namodenoson-Gi1/β1/γ2 8X16-A3A-Piclidenoson-Gi1/β1/γ2
16.67Consensusadrenergic_offOrthosteric Ligandalpha_off beta_off
16.67Consensusadrenergic_on_gpOrthosteric Ligandalpha_on_gp beta_on_gp
16.67Consensusalpha2c_offOrthosteric Ligand6KUW-α2c-PubChem 57213234
16.67Consensusalpha_offOrthosteric Ligandalpha1_off alpha2_off
16.67Consensusalpha_on_gpOrthosteric Ligandalpha1_on_gp alpha2_on_gp
16.67Consensusbb2_offOrthosteric Ligand7W41-BB2-PD176252
16.67Consensusbombesin_offOrthosteric Ligandbb2_off
16.67Consensusc5a1_onOrthosteric Ligand8HK5-C5a1-Complement C5-Gi1/β1/γ2 7Y66-C5a1-BM213-Gi1/β1/γ2 7Y67-C5a1-C089 peptide-Gi1/β1/γ2 7Y64-C5a1-C5a anaphylatoxin-Gi1/β1/γ2
16.67Consensuscb2_onOrthosteric Ligand8GUR-CB2-CP55,940-Gi1/β1/γ2 8GUS-CB2-HU-308-Gi1/β1/γ2 8GUT-CB2-LEI-102-Gi1/β1/γ2 6KPF-CB2-PubChem 145915889-Gi1/β1/γ2 6PT0-CB2-WIN 55212-2-Gi1/β1/γ2 8GUQ-CB2-Olorinab-Gi1/β1/γ2
16.67Consensuscb2_on_gpOrthosteric Ligand8GUR-CB2-CP55,940-Gi1/β1/γ2 8GUS-CB2-HU-308-Gi1/β1/γ2 8GUT-CB2-LEI-102-Gi1/β1/γ2 6KPF-CB2-PubChem 145915889-Gi1/β1/γ2 6PT0-CB2-WIN 55212-2-Gi1/β1/γ2 8GUQ-CB2-Olorinab-Gi1/β1/γ2
16.67Consensuscckb_on_gpOrthosteric Ligand8IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/β1/γ2 7XOW-CCKB-Gastrin-chim(NtGi1-Gq)/β1/γ2 7F8V-CCKB-Gastrin-17-Gi2/β1/γ2
16.67Consensuscxcr4_on_gpOrthosteric Ligand8K3Z-CXCR4-CXCL12-Gi1/β1/γ1
16.67Consensusd1_onOrthosteric Ligand7F0T-D1-Dopamine-Gs/β1/γ2 7CKY-D1-PW0464-Gs/β1/γ2 8IRR-D1-Rotigotine-Gs/β1/γ2 7JV5-D1-SKF81297-Gs/β1/γ2 7JVP-D1-SKF83959-Gs/β1/γ2 7X2D-D1-Tavapadon-Gs/β1/γ2 7CKX-D1-A77636-Gs/β1/γ2 7JVQ-D1-Apomorphine-Gs/β1/γ2 7CKW-D1-Fenoldopam-Gs/β1/γ2
16.67Consensusd2_onOrthosteric Ligand7JVR-D2-Bromoergocryptine-Gi1/β1/γ2 8IRS-D2-Rotigotine-Gi1/β1/γ2
16.67Consensusd4_onOrthosteric Ligand8IRU-D4-Rotigotine-chim(NtGi1-Gs-CtGi1)/β1/γ2
16.67Consensusdp2_offOrthosteric Ligand6D26-DP2-Fevipiprant
16.67Consensusdp_offOrthosteric Liganddp2_off
16.67Consensusep4_offOrthosteric Ligand5YWY-EP4-ONO-AE3-208 5YHL-EP4-PubChem 135121352
16.67Consensusep_offOrthosteric Ligandep4_off
16.67Consensusetb_on_gpOrthosteric Ligand8IY5-ETB-Endothelin-1-Gi1/β1/γ2 8HBD-ETB-IRL1620-Gi1/β1/γ2
16.67Consensusgs_cckOrthosteric Ligand7MBX-CCKA-Cholecystokinin-8-Gs/β1/γ1
16.67Consensush1_offOrthosteric Ligand8X63-H1-Mepyramine 3RZE-H1-Cidoxepin 8X5Y-H1-Astemizole
16.67Consensusm3_onOrthosteric Ligand8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/β1/γ2 8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/β1/γ2 8E9Y-M3-Clozapine-N-oxide-chim(NtGi2L-Gs-CtGq)/β1/γ2
16.67Consensusm3_on_gpOrthosteric Ligand8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/β1/γ2 8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/β1/γ2 8E9Y-M3-Clozapine-N-oxide-chim(NtGi2L-Gs-CtGq)/β1/γ2
16.28Consensusgs_peptideOrthosteric Ligandgs_cck gs_melanocortin gs_vasop-oxy
16.22Single6METEnvelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd46MET-CCR5-Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4
16.22Single7AD3Alpha-factor mating pheromone7AD3-STE2-α-factor mating pheromone-Gi1/STE4/γ2
16.22Single7F4HAfamelanotide7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2
16.22Single7T10Somatostatin-147T10-SST2-Somatostatin-14-Gi3/β1/γ2
16.22Single8IEDA1LYA8IED-GPR156-A1LYA-Go/β1/γ2
16.22Single8XWQEndothelin-18XWQ-ETB-Endothelin-1-Gi1/β1/γ2
16.22Consensusc5a1_on_gpOrthosteric Ligand8HK5-C5a1-Complement C5-Gi1/β1/γ2 7Y66-C5a1-BM213-Gi1/β1/γ2 7Y67-C5a1-C089 peptide-Gi1/β1/γ2 7Y64-C5a1-C5a anaphylatoxin-Gi1/β1/γ2
16.22Consensusneuromedin-u_onOrthosteric Ligandnmur1_on nmur2_on
16.13Single4LDLHydroxybenzylisoproterenol4LDL-β2-Hydroxybenzylisoproterenol
16.13Single4U15Tiotropium4U15-M3-Tiotropium
16.13Single5ZHPPubChem 1348285895ZHP-M3-PubChem 134828589
16.13Single6H7JIsoprenaline6H7J-β1-Isoprenaline
16.13Single6KO5PubChem 574000026KO5-Ghrelin-PubChem 57400002
16.13Single6N48BI1671076N48-β2-BI167107-PubChem 138454256
16.13Single6N4BMDMB-Fubinaca6N4B-CB1-MDMB-Fubinaca-Gi1/β1/γ2
16.13Single6NI3BI1671076NI3-β2-BI167107-Gs/β1/γ2
16.13Single6OL9Tiotropium6OL9-M5-Tiotropium
16.13Single6WGTLSD6WGT-5-HT2A-LSD
16.13Single7EW3S1P7EW3-S1P3-S1P-Gi1/β1/γ2
16.13Single7JJOIsoprenaline7JJO-β1-Isoprenaline-Gs/β1/γ2
16.13Single7JV5SKF812977JV5-D1-SKF81297-Gs/β1/γ2
16.13Single7JVPSKF839597JVP-D1-SKF83959-Gs/β1/γ2
16.13Single7T9NPubChem 6440787T9N-TSH-M22 Fab-PubChem 644078-Gs/β1/γ2
16.13Single7TUYGSK682753A7TUY-GPR183-GSK682753A
16.13Single7WVXHumanin7WVX-FPR2-ALX-Humanin-Gi2/β1/γ2
16.13Single7XOWGastrin7XOW-CCKB-Gastrin-chim(NtGi1-Gq)/β1/γ2
16.13Single7XY7NECA7XY7-A2B-NECA-chim(NtGi1-Gs)/β1/γ2
16.13Single7YU7ONO-07405567YU7-LPA1-ONO-0740556-Gi1/β1/γ2
16.13Single8DCSCyanopindolol8DCS-β1-Cyanopindolol-Gs/β1/γ2
16.13Single8HQCC5a anaphylatoxin8HQC-C5a1-C5a anaphylatoxin-Go/β1/γ2
16.13Single8I9LC3a anaphylatoxin8I9L-C3aB-C3a anaphylatoxin-Go/β1/γ2
16.13Single8ID39-Hydroxystearic acid8ID3-FFA4-9-Hydroxystearic acid-Gi1/β1/γ2
16.13Single8JT6(R)-IHCH-71798JT6-5-HT1A-(R)-IHCH-7179-Gi1/β1/γ2
16.13Single8JXVClozapine8JXV-H4-Clozapine-Gi1/β1/γ2
16.13Single8JXWVUF68848JXW-H4-VUF6884-Gi1/β1/γ2
16.13Single8VVFJDTic8VVF-κ-JDTic-Gi1/β1/γ2
16.13Single8WJXADP8WJX-P2Y1-ADP-chim(Gs-CtGq)/β1/γ2
16.13Single8X79MRE-2698X79-I2-MRE-269-Gs/β1/γ2
16.13Single8XZICMF-0198XZI-Apelin-CMF-019-Gi1/β1/γ2
16.13Single8YNTSNAP-948478YNT-MCH1-SNAP-94847
16.13Single9B65KCA9B65-CB1-KCA-Gi1/β1/γ2
16.13Single9IZGNKP9IZG-LPA1-NKP-chim(NtGi1-Gs-CtGq)/β1/γ2
16.13Consensusbeta2_onOrthosteric Ligand7DHI-β2-Salbutamol-Gs/β1/γ2 6NI3-β2-BI167107-Gs/β1/γ2
16.13Consensusbeta2_on_gpOrthosteric Ligand7DHI-β2-Salbutamol-Gs/β1/γ2 6NI3-β2-BI167107-Gs/β1/γ2
16.13Consensusgi_5htOrthosteric Ligand8FYT-5-HT1A-LSD-Gi1/β1/γ1 7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/β1/γ2 8UGY-5-HT1E-Mianserin-Gi1/β1/γ1 8W8B-5-HT1A-SEP-363856-Gi1/β1/γ2 7E2Y-5-HT1A-Serotonin-Gi1/β1/γ2 7E32-5-HT1D-Serotonin-Gi1/β1/γ2 7XTA-5-HT4-Serotonin-Gi1/β1/γ2 8UH3-5-HT1E-Setiptiline-Gi1/β1/γ1 8JSP-5-HT1A-Ulotaront-Gi1/β1/γ2 8FYL-5-HT1A-Vilazodone-Gi1/β1/γ1 8JT6-5-HT1A-(R)-IHCH-7179-Gi1/β1/γ2 8FYE-5-HT1A-4-F,5-MeO-PyrT-Gi1/β1/γ1 7X5H-5-HT5A-5-CT-Gi1/β1/γ2 8FY8-5-HT1A-5-MeO-DMT-Gi1/β1/γ1 7E2Z-5-HT1A-Aripiprazole-Gi1/β1/γ2 7E33-5-HT1E-BRL-54443-Gi1/β1/γ2 8FYX-5-HT1A-Buspirone-Gi1/β1/γ1 7EXD-5-HT1F-Lasmiditan-Gi1/β1/γ2 7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/β1/γ2
16.13Consensusgi_cannabinoidOrthosteric Ligand8GUR-CB2-CP55,940-Gi1/β1/γ2 8GUS-CB2-HU-308-Gi1/β1/γ2 8GUT-CB2-LEI-102-Gi1/β1/γ2 8GUQ-CB2-Olorinab-Gi1/β1/γ2 6KPF-CB2-PubChem 145915889-Gi1/β1/γ2 6PT0-CB2-WIN 55212-2-Gi1/β1/γ2 6KPG-CB1-AM841-Gi1/β1/γ2
16.13Consensusgi_dopamineOrthosteric Ligand7JVR-D2-Bromoergocryptine-Gi1/β1/γ2 7CMV-D3-PD128907-Gi1/β1/γ2 7CMU-D3-Pramipexole-Gi1/β1/γ2 8IRS-D2-Rotigotine-Gi1/β1/γ2 8IRT-D3-Rotigotine-Gi1/β1/γ2
16.13Consensusgs_adrenergicOrthosteric Ligand7DHI-β2-Salbutamol-Gs/β1/γ2 7XJI-β3-Solabegron-Gs/β1/γ2 7JJO-β1-Isoprenaline-Gs/β1/γ2 6NI3-β2-BI167107-Gs/β1/γ2 8DCR-β1-Dobutamine-Gs/β1/γ2 7XJH-β3-Isoproterenol-Gs/β1/γ2 7DH5-β3-Mirabegron-Gs/β1/γ2
16.13Consensusm3_offOrthosteric Ligand4U15-M3-Tiotropium 4U16-M3-N-Methyl-Scopolamine 5ZHP-M3-PubChem 134828589
16.13Consensusm5_offOrthosteric Ligand6OL9-M5-Tiotropium
16.00Single2HPYAll-trans-Retinal2HPY-Rhodopsin-All-trans-Retinal
16.00Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
16.00Single7MTBAll-trans-Retinal7MTB-Rhodopsin-All-trans-Retinal-GRK1
16.00Single8DPHLorcaserin8DPH-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/β1/γ2
16.00Single9C2FCa; Ca; Tryptophan; '6218; PO49C2F-CaS-Ca-Ca; Ca; Tryptophan; '6218; PO4
16.00Consensusopsins_onOrthosteric Ligandrhodopsin_on opsin1lw_on
16.00Consensussensory_onOrthosteric Ligandopsins_on
15.79Single7X9CPancreatic Hormone7X9C-Y4-Pancreatic Hormone-Gi1/β1/γ2
15.79Single8HCXEndothelin-18HCX-ETB-Endothelin-1-chim(NtGi2L-Gs-CtGq)/β1/γ2
15.79Single8HK5Complement C58HK5-C5a1-Complement C5-Gi1/β1/γ2
15.79Single8XVIEndothelin-18XVI-ETA-Endothelin-1-chim(Gs-CtGq)/β1/γ2
15.79Consensusneuromedin-u_on_gpOrthosteric Ligandnmur1_on_gp nmur2_on_gp
15.62Single2YCXCyanopindolol2YCX-β1-Cyanopindolol
15.62Single4LDEBI1671074LDE-β2-BI167107
15.62Single4XEENeurotensin4XEE-NTS1-Neurotensin
15.62Single4XESNeurotensin4XES-NTS1-Neurotensin
15.62Single4Z36ONO-30805734Z36-LPA1-ONO-3080573
15.62Single5F8UCyanopindolol5F8U-β1-Cyanopindolol
15.62Single5X33BIIL2605X33-BLT1-BIIL260
15.62Single6AK3Dinoprostone IPGE26AK3-EP3-Dinoprostone IPGE2
15.62Single6C1RPMX536C1R-C5a1-PMX53-Avacopan; Na
15.62Single6DRYMethylergonovine6DRY-5-HT2B-Methylergonovine
15.62Single6IIURamatroban6IIU-TP-Ramatroban
15.62Single6VMSBromoergocryptine6VMS-D2-Bromoergocryptine-Gi1/β1/γ2
15.62Single6YVRNTS8-136YVR-NTS1-NTS8-13
15.62Single7DH5Mirabegron7DH5-β3-Mirabegron-Gs/β1/γ2
15.62Single7W0LPubChem 1227019087W0L-Apelin-PubChem 122701908-Gi1/β1/γ2
15.62Single7W0NElabela7W0N-Apelin-Elabela-Gi1/β1/γ2
15.62Single7XMTJ-21567XMT-SST4-J-2156-Gi1/β1/γ2
15.62Single7XW5ML1097XW5-TSH-TSH-ML109-Gs/β1/γ2
15.62Single7Y66BM2137Y66-C5a1-BM213-Gi1/β1/γ2
15.62Single7YMJTamsulosin7YMJ-Alpha1A-Tamsulosin
15.62Single8GCPPGE28GCP-EP4-PGE2-Gi1/β1/γ2
15.62Single8HK2C3a anaphylatoxin8HK2-C3aB-C3a anaphylatoxin-Gi1/β1/γ2
15.62Single8I9AEP548I9A-C3aB-EP54-chim(NtGi1-Gs-CtGq)/β1/γ2
15.62Single8ID9Eicosapentaenoic acid8ID9-FFA4-Eicosapentaenoic acid-Gi1/β1/γ2
15.62Single8IQ6Latanoprost8IQ6-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/β1/γ2
15.62Single8IRSRotigotine8IRS-D2-Rotigotine-Gi1/β1/γ2
15.62Single8JJ8Formoterol8JJ8-β2-Formoterol
15.62Single8JJPChemerin8JJP-CML2-Chemerin-Gi1/β1/γ2
15.62Single8JPCNeurotensin-(8-13)8JPC-NTS1-Neurotensin-(8-13)-PubChem 118610427; GDP; Mg-Gq; GRK2
15.62Single8JWY2-1188JWY-A2A-2-118
15.62Single8JWZAB9288JWZ-A2A-AB928-Na
15.62Single8T3QDocosa-4,7,10,13,16,19-Hexaenoic acid8T3Q-FFA4-Docosa-4,7,10,13,16,19-Hexaenoic acid-chim(NtGi2L-Gs-CtGq)/β1/γ2
15.62Single9IZHLPA9IZH-LPA1-LPA-chim(NtGi2-G13)/β1/γ2
15.62Single9L3WRetinoic acid receptor responder protein 29L3W-CML1-Retinoic acid receptor responder protein 2-Gi1/β1/γ2
15.62Consensus5ht1a_onOrthosteric Ligand8FYT-5-HT1A-LSD-Gi1/β1/γ1 7E2Y-5-HT1A-Serotonin-Gi1/β1/γ2 7E2Z-5-HT1A-Aripiprazole-Gi1/β1/γ2 8FYX-5-HT1A-Buspirone-Gi1/β1/γ1 8JSP-5-HT1A-Ulotaront-Gi1/β1/γ2 8JT6-5-HT1A-(R)-IHCH-7179-Gi1/β1/γ2 8FY8-5-HT1A-5-MeO-DMT-Gi1/β1/γ1 8FYE-5-HT1A-4-F,5-MeO-PyrT-Gi1/β1/γ1 8FYL-5-HT1A-Vilazodone-Gi1/β1/γ1
15.62Consensus5ht1a_on_gpOrthosteric Ligand8FYT-5-HT1A-LSD-Gi1/β1/γ1 8FYX-5-HT1A-Buspirone-Gi1/β1/γ1 8JSP-5-HT1A-Ulotaront-Gi1/β1/γ2 8JT6-5-HT1A-(R)-IHCH-7179-Gi1/β1/γ2 7E2Y-5-HT1A-Serotonin-Gi1/β1/γ2 7E2Z-5-HT1A-Aripiprazole-Gi1/β1/γ2 8FY8-5-HT1A-5-MeO-DMT-Gi1/β1/γ1 8FYE-5-HT1A-4-F,5-MeO-PyrT-Gi1/β1/γ1 8FYL-5-HT1A-Vilazodone-Gi1/β1/γ1
15.62Consensusalpha1_offOrthosteric Ligandalpha1a_off
15.62Consensusalpha1a_offOrthosteric Ligand7YMJ-Alpha1A-Tamsulosin
15.62Consensusbeta_onOrthosteric Ligandbeta1_on beta2_on beta3_on
15.62Consensusbeta_on_gpOrthosteric Ligandbeta1_on_gp beta2_on_gp beta3_on_gp
15.62Consensuscannabinoid_onOrthosteric Ligandcb2_on cb1_on
15.62Consensuscannabinoid_on_gpOrthosteric Ligandcb2_on_gp cb1_on_gp
15.62Consensusccr8_onOrthosteric Ligand8KFX-CCR8-LMD-009-Gi1/β1/γ2 8KFY-CCR8-ZK-756326-Gi1/β1/γ2 8U1U-CCR8-CCL1-Gi1/β1/γ2
15.62Consensuscxcr_onOrthosteric Ligandcxcr3_on cxcr4_on cxcr1_on cxcr2_on
15.62Consensusd2_on_gpOrthosteric Ligand7JVR-D2-Bromoergocryptine-Gi1/β1/γ2 8IRS-D2-Rotigotine-Gi1/β1/γ2
15.62Consensusgi_amineOrthosteric Ligandgi_5ht gi_muscarinic gi_adrenergic gi_dopamine gi_histamine
15.62Consensusgi_lipidOrthosteric Ligandgi_cannabinoid gi_ffa gi_leukotriene gi_lpa gi_s1p
15.62Consensusgi_muscarinicOrthosteric Ligand8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/β1/γ2 7T8X-M2-Acetylcholine-chim(NtGi1-Go)/β1/γ2 7TRS-M4-Acetylcholine-Gi1/β1/γ2 7TRK-M4-Iperoxo-Gi1/β1/γ2 7V6A-M4-PubChem 9864275-Gi1/β1/γ2
15.62Consensuskop_onOrthosteric Ligand8F7W-κ-Dynorphin-Gi1/β1/γ2 8DZS-κ-GR89,696-chim(NtGi2-Gz)/β1/γ2 8DZP-κ-momSalB-Gi1/β1/γ2
15.62Consensuslipid_offonOrthosteric Ligandlipid_off lipid_on
15.62Consensuslipid_offon_gpOrthosteric Ligandlipid_on_gp lipid_off
15.62Consensusm4_onOrthosteric Ligand7TRS-M4-Acetylcholine-Gi1/β1/γ2 7V6A-M4-PubChem 9864275-Gi1/β1/γ2 8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/β1/γ2 7TRK-M4-Iperoxo-Gi1/β1/γ2
15.62Consensusm4_on_gpOrthosteric Ligand7TRS-M4-Acetylcholine-Gi1/β1/γ2 7V6A-M4-PubChem 9864275-Gi1/β1/γ2 8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/β1/γ2 7TRK-M4-Iperoxo-Gi1/β1/γ2
15.62Consensusnk1_offOrthosteric Ligand6HLP-NK1-Netupitant 6HLO-NK1-Aprepitant 6HLL-NK1-CP99994 6E59-NK1-L-760735
15.62Consensusorexin_onOrthosteric Ligandox2_on
15.38Single2J4Y11-cis-Retinal2J4Y-Rhodopsin-11-cis-Retinal
15.38Single3C9M11-cis-Retinal3C9M-Rhodopsin-11-cis-Retinal
15.38Single3OE6IT1t3OE6-CXCR4-IT1t
15.38Single3PQRAll-trans-Retinal3PQR-Rhodopsin-All-trans-Retinal-Gt(CT)
15.38Single7EJKOxymetazoline7EJK-α2a-Oxymetazoline-Go/β1/γ2
15.38Single7F23Dopamine7F23-D1-Dopamine-GDP-Gs/β1/γ2
15.38Single7SK3CXCL127SK3-ACKR3-CXCL12
15.38Single8GGEConstrained Epinephrine8GGE-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
15.38Single8GGFConstrained Epinephrine8GGF-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
15.38Single8GH1Constrained Epinephrine8GH1-β2-Constrained Epinephrine
15.38Single8JRVGlucagon8JRV-Glucagon-Glucagon-Arrestin2
15.38Single8RQLFlufenamic acid8RQL-TAS2R14-Flufenamic acid-Flufenamic acid-chim(NtGi1-Gt3)/β1/γ2
15.38Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
15.38Single8WC62-Phenylethylamine8WC6-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/β1/γ2
15.38Single8WC9ZH86518WC9-TA1-ZH8651-chim(NtGi1-Gs-CtGq)/β1/γ2
15.38Single8XQFApelin-138XQF-Apelin-Apelin-13-Gi1/β1/γ2
15.38Single8YN9Histamine8YN9-H4-Histamine-Gi1/β1/γ2
15.38Single8YUUHistamine8YUU-H3-Histamine-Gi1/β1/γ1
15.38Single9C1PCa; Tryptophan; '6218; PO49C1P-CaS-Ca-Ca; Tryptophan; '6218; PO4
15.38Consensush3_onOrthosteric Ligand8YUU-H3-Histamine-Gi1/β1/γ1
15.38Consensush3_on_gpOrthosteric Ligand8YUU-H3-Histamine-Gi1/β1/γ1
15.38Consensusnpy4_onOrthosteric Ligand7X9C-Y4-Pancreatic Hormone-Gi1/β1/γ2
15.38Consensusnpy4_on_gpOrthosteric Ligand7X9C-Y4-Pancreatic Hormone-Gi1/β1/γ2
15.38Consensusopsins_on_gpOrthosteric Ligandrhodopsin_on_gp opsin1lw_on_gp
15.38Consensusrhodopsin_onOrthosteric Ligand6OYA-Rhodopsin-All-trans-Retinal-Gt/β1/γ1
15.38Consensussensory_on_gpOrthosteric Ligandopsins_on_gp
15.22Consensusmc2_onOrthosteric Ligand8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1
15.22Consensusmc2_on_gpOrthosteric Ligand8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1
15.15Single4BUONeurotensin4BUO-NTS1-Neurotensin
15.15Single5TUDErgotamine5TUD-5-HT2B-Ergotamine
15.15Single6H7LDobutamine6H7L-β1-Dobutamine
15.15Single6IBLArformoterol6IBL-β1-Arformoterol
15.15Single6TKOArformoterol6TKO-β1-Arformoterol-Arrestin2
15.15Single7D7MDinoprostone7D7M-EP4-Dinoprostone-Gs/β1/γ1
15.15Single7EZHCholecystokinin-87EZH-CCKA-Cholecystokinin-8-Gi1/β1/γ2
15.15Single7EZMCholecystokinin-87EZM-CCKA-Cholecystokinin-8-chim(NtGsL-Gq)/β1/γ2
15.15Single7JVRBromoergocryptine7JVR-D2-Bromoergocryptine-Gi1/β1/γ2
15.15Single7UM4AS26747237UM4-5-HT5A-AS2674723
15.15Single7WVVfMLFII7WVV-FPR2-ALX-fMLFII-Gi2/β1/γ2
15.15Single7X1UTRH7X1U-TRH-TRH-chim(NtGi2L-Gs-CtGq)/β1/γ2
15.15Single7YU8ONO-07405567YU8-LPA1-ONO-0740556-Gi1/β1/γ2
15.15Single8E9YClozapine-N-oxide8E9Y-M3-Clozapine-N-oxide-chim(NtGi2L-Gs-CtGq)/β1/γ2
15.15Single8FN0Neurotensin/Neuromedin-N8FN0-NTS1-Neurotensin/Neuromedin-N-PubChem 118610427-chim(NtGi1-Go)/β1/γ2
15.15Single8GAGPubChem 1708384908GAG-CB1-PubChem 170838490-Gi1/β1/γ2
15.15Single8GUTLEI-1028GUT-CB2-LEI-102-Gi1/β1/γ2
15.15Single8HN1Toxin AdTx18HN1-Alpha1A-Toxin AdTx1
15.15Single8I95EP548I95-C3aB-EP54-Go/β1/γ2
15.15Single8IYSTUG-8918IYS-FFA4-TUG-891-GDP-chim(NtGi1L-Gq)/β1/γ2
15.15Single8K2XCXCL108K2X-CXCR3-CXCL10-Gi1/β1/γ2
15.15Single8K4OCXCL18K4O-KSHV-CXCL1-Gi1/β1/γ1
15.15Single8XVJMacitentan8XVJ-ETA-Macitentan
15.15Single8XVUCXCL28XVU-CXCR2-CXCL2
15.15Single8XXHCXCL28XXH-CXCR2-CXCL2-Go/β1/γ2
15.15Single9EAILosartan9EAI-AT1-Losartan-Nanobody AT209
15.15Consensusbeta1_onOrthosteric Ligand8DCR-β1-Dobutamine-Gs/β1/γ2 7S0F-β1-Isoprenaline-Gi1/β1/γ2
15.15Consensusbeta1_on_gpOrthosteric Ligand8DCR-β1-Dobutamine-Gs/β1/γ2 7S0F-β1-Isoprenaline-Gi1/β1/γ2
15.15Consensuscb1_on_gpOrthosteric Ligand6KPG-CB1-AM841-Gi1/β1/γ2 8K8J-CB1-Fenofibrate-chim(Gs-CtGq)/β1/γ2
15.15Consensusccka_onOrthosteric Ligand7EZH-CCKA-Cholecystokinin-8-Gi1/β1/γ2
15.15Consensusccka_on_gpOrthosteric Ligand7EZH-CCKA-Cholecystokinin-8-Gi1/β1/γ2
15.15Consensuschemerin_onOrthosteric Ligandcml1_on
15.15Consensusfp-alpha_onOrthosteric Ligand8IUK-FP-alpha-PGF2-α-chim(NtGi1-Gs-CtGq)/β1/γ2 8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/β1/γ2 8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/β1/γ2
15.15Consensusfp-alpha_on_gpOrthosteric Ligand8IUK-FP-alpha-PGF2-α-chim(NtGi1-Gs-CtGq)/β1/γ2 8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/β1/γ2 8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/β1/γ2
15.15Consensusgal2_onOrthosteric Ligand7WQ4-GAL2-Galanin-chim(NtGi1-Gs-CtGq)/β1/γ2 7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/β1/γ2
15.15Consensusgal2_on_gpOrthosteric Ligand7WQ4-GAL2-Galanin-chim(NtGi1-Gs-CtGq)/β1/γ2 7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/β1/γ2
15.15Consensusnucleotide_on_gpOrthosteric Ligandadenosine_on_gp p2y_on_gp
15.15Consensusorexin_on_gpOrthosteric Ligandox2_on_gp
15.00Single7F53Alpha-MSH7F53-MC4-α-MSH-Gs/β1/γ2
14.81Single1L9H11-cis-Retinal1L9H-Rhodopsin-11-cis-Retinal
14.81Single1U1911-cis-Retinal1U19-Rhodopsin-11-cis-Retinal
14.81Single2G87All-trans-Retinal2G87-Rhodopsin-All-trans-Retinal
14.81Single2I3511-cis-Retinal2I35-Rhodopsin-11-cis-Retinal
14.81Single4O9RCyclopamine4O9R-SMO-Cyclopamine
14.81Single5L7IVismodegib5L7I-SMO-Vismodegib
14.81Single5TE520-Methanoretinal5TE5-Rhodopsin-20-Methanoretinal
14.81Single6FK6PubChem 1324730336FK6-Rhodopsin-PubChem 132473033
14.81Single6LI0C176LI0-GPR52-C17
14.81Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
14.81Single7XKFBeta-Hydroxyandrosterone7XKF-ADGRG2-β-Hydroxyandrosterone-Gs/β1/γ2
14.81Single7XP6Strychnine7XP6-T2R46-Strychnine-chim(Gs-CtGt3)/β1/γ2
14.81Single7XT9Serotonin7XT9-5-HT4-Serotonin-Gs/β1/γ2
14.81Single7YFCHistamine7YFC-H4-Histamine-chim(NtGi1-Gs-CtGq)/β1/γ2
14.81Single8DPFLorcaserin8DPF-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/β1/γ2
14.81Single8GGYConstrained Epinephrine8GGY-β2-Constrained Epinephrine
14.81Single8JLOUlotaront8JLO-TA1-Ulotaront-Gs/β1/γ2
14.81Single8JPNCis-Epoxysuccinic acid8JPN-Succinate-Cis-Epoxysuccinic acid-Gi1/β1/γ1
14.81Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
14.81Single8U4RREGN7663-Fab8U4R-CXCR4-REGN7663-Fab-Cholesterol
14.81Single8UO3Constrained Epinephrine8UO3-β2-Constrained Epinephrine-GTP; Mg-Gs/β1/γ2
14.81Single8WP1Cis-Epoxysuccinic acid8WP1-Succinate-Cis-Epoxysuccinic acid-Gi1/β1/γ2
14.81Single8YH3N-methyladenosine8YH3-A3A-N-methyladenosine-Gi1/β1/γ2
14.81Single8YKWSuccinic acid8YKW-Succinate-Succinic acid-Gi1/β1/γ1
14.81Single8YN5Histamine8YN5-H3-Histamine-Gi1/β1/γ2
14.81Single8YN6Imetit8YN6-H3-Imetit-Gi1/β1/γ2
14.81Single8YN7Immethridine8YN7-H3-Immethridine-Go1/β1/γ2
14.81Single8YUVImmepip8YUV-H3-Immepip-Gi1/β1/γ2
14.81Single8ZX5AM2518ZX5-GPR55-AM251-chim(NtGi1-G13)/β1/γ2
14.81Single9B9Y7DY9B9Y-CB1-7DY
14.71Single6C1QPMX536C1Q-C5a1-PMX53-NDT9513727
14.71Single6G79Donitriptan6G79-5-HT1B-Donitriptan-Go/β1/γ2
14.71Single6OMMWKYMVX6OMM-FPR2-ALX-WKYMVX-Gi1/β1/γ2
14.71Single6PT3DPI-2876PT3-δ-DPI-287
14.71Single7RKFFractalkine7RKF-US28-Fractalkine-GDP-chim(NtGi1-G11)/β1/γ2
14.71Single7Y1FDynorphin7Y1F-κ-Dynorphin-Gi1/β1/γ2
14.71Single8GDAL9026888GDA-EP4-L902688-Gs/β1/γ2
14.71Single8IEIA1LYA8IEI-GPR156-A1LYA
14.71Single8IQ4Carboprost8IQ4-FP-alpha-Carboprost-chim(NtGi1-Gs-CtGq)/β1/γ2
14.71Single8IUMTafluprost acid8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/β1/γ2
14.71Single8X3LXWD8X3L-CB2-XWD-Gi1/β1/γ2
14.71Single9EAJNanobody AT2099EAJ-AT1-Nanobody AT209
14.71Single9ERXD9-THC analog9ERX-CB1-D9-THC analog-Gi1/β1/γ2
14.71Consensusdop_onOrthosteric Ligand8F7S-δ-Deltorphin-Gi1/β1/γ2
14.71Consensusnmur1_onOrthosteric Ligand7W53-NMUR1-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
14.63Single8IY5Endothelin-18IY5-ETB-Endothelin-1-Gi1/β1/γ2
14.63Consensusetb_onOrthosteric Ligand8IY5-ETB-Endothelin-1-Gi1/β1/γ2 8HBD-ETB-IRL1620-Gi1/β1/γ2
14.63Consensusgs_melanocortinOrthosteric Ligand7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2 7F54-MC4-Afamelanotide-Gs/β1/γ2 7F4D-MC1-α-MSH-chim(NtGi1-Gs)/β1/γ2 8INR-MC5-α-MSH-Ca-chim(NtGi1-Gs)/β1/γ2 7F53-MC4-α-MSH-Gs/β1/γ2 7F55-MC4-Bremelanotide-Gs/β1/γ2 8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1 8IOC-MC3-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2 8IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/β1/γ2 7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2 7F4I-MC1-SHU9119-chim(NtGi1-Gs)/β1/γ2 7F58-MC4-THIQ-Gs/β1/γ2
14.29Single1GZM11-cis-Retinal1GZM-Rhodopsin-11-cis-Retinal
14.29Single2PED9-cis-Retinal2PED-Rhodopsin-9-cis-Retinal
14.29Single2X72All-trans-Retinal2X72-Rhodopsin-All-trans-Retinal-Gt(CT)
14.29Single3C9L11-cis-Retinal3C9L-Rhodopsin-11-cis-Retinal
14.29Single3ODUIT1t3ODU-CXCR4-IT1t
14.29Single3VG9ZM-2413853VG9-A2A-ZM-241385-Antibody
14.29Single4BWBNeurotensin4BWB-NTS1-Neurotensin
14.29Single4IARErgotamine4IAR-5-HT1B-Ergotamine
14.29Single4MQTLY21196204MQT-M2-Iperoxo-LY2119620
14.29Single4QINSAG1.54QIN-SMO-SAG1.5
14.29Single4S0VSuvorexant4S0V-OX2-Suvorexant
14.29Single5K2DZM-2413855K2D-A2A-ZM-241385-Na
14.29Single5OLOTozadenant5OLO-A2A-Tozadenant-Na
14.29Single5U09Taranabant5U09-CB1-Taranabant
14.29Single5WS3EMPA5WS3-OX2-EMPA
14.29Single5ZKQABT-4915ZKQ-PAF-ABT-491
14.29Single6AKXA4R6AKX-CCR5-A4R
14.29Single6AKYMaraviroc6AKY-CCR5-Maraviroc
14.29Single6JZHZM-2413856JZH-A2A-ZM-241385-Na
14.29Single6O3CSAG21k6O3C-SMO-SAG21k-Cholesterol
14.29Single6OBAS-Alprenolol6OBA-β2-S-Alprenolol-GTPL11074
14.29Single6PS7ZM-2413856PS7-A2A-ZM-241385-Na
14.29Single6TODEMPA6TOD-OX1-EMPA-Na
14.29Single6TPJSuvorexant6TPJ-OX2-Suvorexant
14.29Single7BR3Elagolix7BR3-GnRH1-Elagolix
14.29Single7L0RNeurotensin7L0R-NTS1-Neurotensin-Gi1/β1/γ1
14.29Single7LCJDanuglipron7LCJ-GLP-1-Danuglipron
14.29Single7M3ECa; Ca; Tryptophan; NPS-21437M3E-CaS-Ca; Ca; Tryptophan; NPS-2143
14.29Single7M3ECa; Ca; Tryptophan; NPS-21437M3E-CaS-Ca; Ca; Tryptophan; NPS-2143
14.29Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
14.29Single7VIHCBP-3077VIH-S1P1-CBP-307-Gi1/β1/γ2
14.29Single7VUJJNJ-635330547VUJ-GPR139-JNJ-63533054-GDP-chim(Gs-CtGq)/β1/γ2
14.29Single7VVOPTH7VVO-PTH1-PTH-Gs/β1/γ2
14.29Single7W53Neuromedin-U-257W53-NMUR1-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
14.29Single7WKDTRH7WKD-TRH-TRH-chim(NtGi1-Gs-CtGq)/β1/γ2
14.29Single7XT8Serotonin7XT8-5-HT4-Serotonin-Gs/β1/γ2
14.29Single8A6CAll-trans-Retinal8A6C-Rhodopsin-All-trans-Retinal
14.29Single8A6DAll-trans-Retinal8A6D-Rhodopsin-All-trans-Retinal
14.29Single8A6EAll-trans-Retinal8A6E-Rhodopsin-All-trans-Retinal
14.29Single8DU3PubChem 1055260648DU3-A2A-PubChem 105526064
14.29Single8DWGML3828DWG-MRGPRX1-Proenkephalin-A-ML382-chim(NtGi2L-Gs-CtGq)/β1/γ2
14.29Single8FYXBuspirone8FYX-5-HT1A-Buspirone-Gi1/β1/γ1
14.29Single8G59TUG-8918G59-FFA4-TUG-891-chim(Gi1-CtGq)/β1/γ2
14.29Single8GNGIstradefylline8GNG-A2A-Istradefylline
14.29Single8IEBA1LYA8IEB-GPR156-A1LYA
14.29Single8IEIA1LYA8IEI-GPR156-A1LYA
14.29Single8IEPA1LYA8IEP-GPR156-A1LYA
14.29Single8IEPA1LYA8IEP-GPR156-A1LYA
14.29Single8JSOAMPH8JSO-TA1-AMPH-chim(NtGi1-Gs)/β1/γ2
14.29Single8RVWStilSwitch38RVW-A2A-StilSwitch3-Na
14.29Single8RW0Istradefylline8RW0-A2A-Istradefylline-Na
14.29Single8U1UCCL18U1U-CCR8-CCL1-Gi1/β1/γ2
14.29Single8U4OCXCL128U4O-CXCR4-CXCL12-Cholesterol-Gi1/β1/γ2
14.29Single8UNSConstrained Epinephrine8UNS-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
14.29Single8UNTConstrained Epinephrine8UNT-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
14.29Single8WZ2Orexigenic Neuropeptide QRFP8WZ2-QRFP-Orexigenic Neuropeptide QRFP-chim(NtGi1L-Gs-CtGq)/β1/γ2
14.29Single8XXVIndomethacin8XXV-DP2-Indomethacin-A1D5Q-Gi1/β1/γ2
14.29Single9BA0A1AKN9BA0-CB1-A1AKN
14.29Single9BKJCholecystokinin-89BKJ-CCKA-Cholecystokinin-8-chim(NtGi1-Gs-CtGq)/β1/γ2
14.29Single9BQJRO769BQJ-μ-RO76-Gi1/β1/γ2
14.29Consensus5ht1e_onOrthosteric Ligand7E33-5-HT1E-BRL-54443-Gi1/β1/γ2 8UGY-5-HT1E-Mianserin-Gi1/β1/γ1 8UH3-5-HT1E-Setiptiline-Gi1/β1/γ1
14.29Consensusgi_nucleotideOrthosteric Ligandgi_adenosine gi_p2y
14.29Consensusgnrh1_offOrthosteric Ligand7BR3-GnRH1-Elagolix
14.29Consensusgq_histamineOrthosteric Ligand7DFL-H1-Histamine-chim(NtGi1L-Gq)/β1/γ2
14.29Consensush1_on_gpOrthosteric Ligand7DFL-H1-Histamine-chim(NtGi1L-Gq)/β1/γ2
14.29Consensushistamine_onOrthosteric Ligandh1_on h2_on h3_on h4_on
14.29Consensushistamine_on_gpOrthosteric Ligandh1_on_gp h2_on_gp h3_on_gp h4_on_gp
14.29Consensusnmur1_on_gpOrthosteric Ligand7W53-NMUR1-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
14.29Consensusorexin_offOrthosteric Ligandox2_off ox1_off
14.29Consensusox1_offOrthosteric Ligand6TP6-OX1-Filorexant 6TP4-OX1-ACT-462206 6V9S-OX1-GTPL11403 6TOT-OX1-Lemborexant 6TP3-OX1-Nemorexant 6TQ6-OX1-PubChem 145714283 6TQ9-OX1-SB-408124 4ZJC-OX1-SB-674042 4ZJ8-OX1-Suvorexant 6TOD-OX1-EMPA-Na 6TOS-OX1-GSK1059865-Na 6TQ4-OX1-PubChem 16046844-Na
14.29Consensusox2_offOrthosteric Ligand5WQC-OX2-EMPA 6TPN-OX2-HTL6641 7XRR-OX2-Lemborexant 6TPJ-OX2-Suvorexant
14.29Consensusp2y_onOrthosteric Ligandp2y1_on p2y10_on p2y12_on
14.29Consensuspaf_offOrthosteric Ligand5ZKQ-PAF-ABT-491
14.29Consensusrhodopsin_offOrthosteric Ligand1U19-Rhodopsin-11-cis-Retinal 2PED-Rhodopsin-9-cis-Retinal 5TE5-Rhodopsin-20-Methanoretinal
13.95Single7SK6CXCL12_LRHQ7SK6-ACKR3-CXCL12_LRHQ
13.95Single8HBDIRL16208HBD-ETB-IRL1620-Gi1/β1/γ2
13.95Consensusmelanocortin_onOrthosteric Ligandmc1_on mc4_on mc2_on mc3_on mc5_on
13.95Consensusmelanocortin_on_gpOrthosteric Ligandmc1_on_gp mc4_on_gp mc2_on_gp mc3_on_gp mc5_on_gp
13.89Single7DDZJNJ-310200287DDZ-Y2-JNJ-31020028
13.89Single8F7SDeltorphin8F7S-δ-Deltorphin-Gi1/β1/γ2
13.89Single8F7WDynorphin8F7W-κ-Dynorphin-Gi1/β1/γ2
13.89Single8IBVMotilin8IBV-Motilin-Motilin-chim(NtGi1-Gs-CtGq)/β1/γ2
13.89Single8IEBA1LYA8IEB-GPR156-A1LYA
13.89Single8XYDPlatelet Activating Factor8XYD-PAF-Platelet Activating Factor-Gi1/β1/γ2
13.89Consensusccr8_on_gpOrthosteric Ligand8KFX-CCR8-LMD-009-Gi1/β1/γ2 8KFY-CCR8-ZK-756326-Gi1/β1/γ2 8U1U-CCR8-CCL1-Gi1/β1/γ2
13.89Consensusdop_on_gpOrthosteric Ligand8F7S-δ-Deltorphin-Gi1/β1/γ2
13.89Consensusgi_ghrelinOrthosteric Ligand7NA7-Ghrelin-Ghrelin-27-Gi1/β1/γ2 7NA8-Ghrelin-PubChem 178024-Gi1/β1/γ2
13.89Consensusnpy2_offOrthosteric Ligand7DDZ-Y2-JNJ-31020028
13.79Single3OAX11-cis-Retinal3OAX-Rhodopsin-11-cis-Retinal
13.79Single4DKLBeta-Funaltrexamine4DKL-μ-β-Funaltrexamine
13.79Single4MBSMaraviroc4MBS-CCR5-Maraviroc
13.79Single4MQTIperoxo4MQT-M2-Iperoxo-LY2119620
13.79Single4N6HNaltrindole4N6H-δ-Naltrindole-Na
13.79Single5IU4ZM-2413855IU4-A2A-ZM-241385-Na
13.79Single5IUBQ274563445IUB-A2A-Q27456344-Na
13.79Single5K2CZM-2413855K2C-A2A-ZM-241385-Na
13.79Single5NLXZM-2413855NLX-A2A-ZM-241385-Na
13.79Single5NM4ZM-2413855NM4-A2A-ZM-241385-Na
13.79Single5TE3Octyl-Beta-D-Glucopyranoside5TE3-Rhodopsin-Octyl-β-D-Glucopyranoside
13.79Single5UVIZM-2413855UVI-A2A-ZM-241385
13.79Single6A94Zotepine6A94-5-HT2A-Zotepine
13.79Single6AQFZM-2413856AQF-A2A-ZM-241385
13.79Single6FFIMMPEP6FFI-mGlu5-MMPEP
13.79Single6KUXRS-799486KUX-α2a-RS-79948
13.79Single6MH8ZM-2413856MH8-A2A-ZM-241385
13.79Single6PELCitronellol6PEL-Rhodopsin-Citronellol-Gt(CT)
13.79Single6PS5S-Propranolol6PS5-β2-S-Propranolol
13.79Single6TOSGSK10598656TOS-OX1-GSK1059865-Na
13.79Single6TP3Nemorexant6TP3-OX1-Nemorexant
13.79Single6U1NLY21196206U1N-M2-LY2119620-Arrestin2
13.79Single6VI4JDTic6VI4-κ-JDTic
13.79Single6WJCAtropine6WJC-M1-Atropine-Muscarinic toxin 7
13.79Single6XBLSAG6XBL-SMO-SAG-Cholesterol-Gi1/β1/γ2
13.79Single7AROLUF58337ARO-A2A-LUF5833-Na
13.79Single7CKWFenoldopam7CKW-D1-Fenoldopam-Gs/β1/γ2
13.79Single7CKZDopamine7CKZ-D1-Dopamine-Mevidalen-Gs/β1/γ2
13.79Single7CMUPramipexole7CMU-D3-Pramipexole-Gi1/β1/γ2
13.79Single7CMVPD1289077CMV-D3-PD128907-Gi1/β1/γ2
13.79Single7E33BRL-544437E33-5-HT1E-BRL-54443-Gi1/β1/γ2
13.79Single7EJ8Brimonidine7EJ8-α2a-Brimonidine-Go/β1/γ2
13.79Single7F0TDopamine7F0T-D1-Dopamine-Gs/β1/γ2
13.79Single7F1ZDopamine7F1Z-D1-Dopamine-GDP-Gs/β1/γ2
13.79Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
13.79Single7RANPubChem 1645758477RAN-5-HT2A-PubChem 164575847-chim(NtGi2L-Gs-CtGq)/β1/γ2
13.79Single7SR8TAK-9257SR8-OX2-TAK-925-chim(NtGi1L-Gs-CtGq)/β1/γ2
13.79Single7T94PubChem 576644067T94-M2-Acetylcholine-PubChem 57664406-chim(NtGi1-Go)/β1/γ2
13.79Single7UL3Famotidine7UL3-H2-Famotidine
13.79Single7UM7Methylergometrine7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/β1/γ2
13.79Single7VODCariprazine7VOD-5-HT2A-Cariprazine
13.79Single7XOVSR1461317XOV-CCKA-SR146131-Gs/β1/γ2
13.79Single7XXH2MeSADP7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/β1/γ2
13.79Single7ZBC11-cis-Retinal7ZBC-Rhodopsin-11-cis-Retinal
13.79Single7ZBE11-cis-Retinal7ZBE-Rhodopsin-11-cis-Retinal
13.79Single7ZI0SAG7ZI0-SMO-SAG-Cholesterol
13.79Single8DPGPsilocin8DPG-5-HT2C-Psilocin-chim(NtGi2L-Gs-CtGq)/β1/γ2
13.79Single8FCZ11-cis-Retinal8FCZ-Rhodopsin-11-cis-Retinal
13.79Single8GG5Constrained Epinephrine8GG5-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
13.79Single8GG7Constrained Epinephrine8GG7-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
13.79Single8GGLConstrained Epinephrine8GGL-β2-Constrained Epinephrine
13.79Single8GGMConstrained Epinephrine8GGM-β2-Constrained Epinephrine
13.79Single8GGPConstrained Epinephrine8GGP-β2-Constrained Epinephrine
13.79Single8GUQOlorinab8GUQ-CB2-Olorinab-Gi1/β1/γ2
13.79Single8GURCP55,9408GUR-CB2-CP55,940-Gi1/β1/γ2
13.79Single8H4LDoconexent8H4L-FFA4-Doconexent-chim(NtGi1-Gs-CtGq)/β1/γ2
13.79Single8JSPUlotaront8JSP-5-HT1A-Ulotaront-Gi1/β1/γ2
13.79Single8K9KDamgo8K9K-μ-Damgo-Gi3/β1/γ1
13.79Single8RWIStilSwitch28RWI-A2A-StilSwitch2-Na
13.79Single8U02L-Dopamine8U02-D2-L-Dopamine-Go/β1/γ2
13.79Single8UNLConstrained Epinephrine8UNL-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
13.79Single8UNOConstrained Epinephrine8UNO-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
13.79Single8UO1Constrained Epinephrine8UO1-β2-Constrained Epinephrine-GTP; Mg-Gs/β1/γ2
13.79Single8Y45ADL58598Y45-δ-ADL5859-Gi2/β1/γ2
13.79Single8YKVPubChem 1375531688YKV-Succinate-PubChem 137553168-Gi1/β1/γ2
13.79Single8YN3Histamine8YN3-H2-Histamine-Gs/β1/γ2
13.79Single8YN8Proxyfan8YN8-H3-Proxyfan-Go1/β1/γ2
13.79Single8ZPMAMD0708ZPM-CXCR4-AMD070-Cholesterol
13.79Single8ZPNAMD31008ZPN-CXCR4-AMD3100-Cholesterol
13.79Single9CBLEpinephrine9CBL-α2a-Epinephrine-Gi1/β1/γ2
13.79Consensus5ht_on_gpOrthosteric Ligand5ht1_on_gp 5ht2_on_gp 5ht4_on_gp 5ht5_on_gp 5ht6_on_gp 5ht7_on_gp
13.79Consensuscb1_offOrthosteric Ligand5U09-CB1-Taranabant 5TGZ-CB1-AM6538
13.79Consensuscxcr2_onOrthosteric Ligand6LFM-CXCR2-Interleukin-8-Gi1/β1/γ2
13.79Consensusd3_onOrthosteric Ligand7CMV-D3-PD128907-Gi1/β1/γ2 8IRT-D3-Rotigotine-Gi1/β1/γ2 7CMU-D3-Pramipexole-Gi1/β1/γ2
13.79Consensusd3_on_gpOrthosteric Ligand7CMV-D3-PD128907-Gi1/β1/γ2 8IRT-D3-Rotigotine-Gi1/β1/γ2 7CMU-D3-Pramipexole-Gi1/β1/γ2
13.79Consensusghrelin_offOrthosteric Ligand6KO5-Ghrelin-PubChem 57400002 7F83-Ghrelin-PF-05190457
13.79Consensusnop_offOrthosteric Ligand4EA3-NOP-PubChem 10296561 5DHG-NOP-C-35 5DHH-NOP-SB-612111
13.79Consensusnucleotide_offOrthosteric Ligandadenosine_off p2y_off
13.79Consensusp2y1_on_gpOrthosteric Ligand7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/β1/γ2
13.51Single3OE0CVX153OE0-CXCR4-CVX15
13.51Single7F4DAlpha-MSH7F4D-MC1-α-MSH-chim(NtGi1-Gs)/β1/γ2
13.51Single7MBXCholecystokinin-87MBX-CCKA-Cholecystokinin-8-Gs/β1/γ1
13.51Single7XOUCholecystokinin-87XOU-CCKA-Cholecystokinin-8-Gs/β1/γ2
13.46Single8GY7Corticotropin8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1
13.33Single1HZX11-cis-Retinal1HZX-Rhodopsin-11-cis-Retinal
13.33Single2VT4Cyanopindolol2VT4-β1-Cyanopindolol
13.33Single2Y01Dobutamine2Y01-β1-Dobutamine
13.33Single2YCYCyanopindolol2YCY-β1-Cyanopindolol
13.33Single4MQSIperoxo4MQS-M2-Iperoxo
13.33Single4U14Tiotropium4U14-M3-Tiotropium
13.33Single5DHGC-355DHG-NOP-C-35
13.33Single5NDDAZ8838; Na5NDD-PAR2-AZ8838; Na
13.33Single5T04Neurotensin5T04-NTS1-Neurotensin
13.33Single5UENDU1725UEN-A1-DU172
13.33Single6D27CAY104716D27-DP2-CAY10471
13.33Single6FFHFenobam6FFH-mGlu5-Fenobam
13.33Single6FK7PubChem 1324730346FK7-Rhodopsin-PubChem 132473034
13.33Single6FKCPubChem 1324730396FKC-Rhodopsin-PubChem 132473039
13.33Single6GPSMK08126GPS-CCR2-MK0812
13.33Single6KPFPubChem 1459158896KPF-CB2-PubChem 145915889-Gi1/β1/γ2
13.33Single6LPJZM-2413856LPJ-A2A-ZM-241385-Na
13.33Single6LPKZM-2413856LPK-A2A-ZM-241385-Na
13.33Single6PRZS-Alprenolol6PRZ-β2-S-Alprenolol
13.33Single6X1ADanuglipron6X1A-GLP-1-Danuglipron-Gs/β1/γ2
13.33Single6Z10PubChem 1545855546Z10-Succinate-PubChem 154585554
13.33Single6Z4VNTS8-136Z4V-NTS1-NTS8-13
13.33Single7BU7BI1671077BU7-β1-BI167107
13.33Single7FIHOrg435537FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/β1/γ2
13.33Single7LCIDanuglipron7LCI-GLP-1-Danuglipron-Gs/β1/γ2
13.33Single7LCKDanuglipron7LCK-GLP-1-Danuglipron
13.33Single7LJCSKF-812977LJC-D1-SKF-81297-Mevidalen-Gs/β1/γ2
13.33Single7S15PubChem 1346112237S15-GLP-1-PubChem 134611223
13.33Single7SCGFH2107SCG-μ-FH210-Gi1/β1/γ2
13.33Single7T6VfMLFII7T6V-FPR2-ALX-fMLFII-Gi1/β1/γ2
13.33Single7TRPIperoxo7TRP-M4-Iperoxo-LY2033298-Gi1/β1/γ2
13.33Single7UM6Lisuride7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/β1/γ2
13.33Single7V3ZCP559407V3Z-CB1-CP55940
13.33Single7VGZRemalteon7VGZ-MT1-Remalteon-Gi1/β1/γ2
13.33Single7X2CFenoldopam7X2C-D1-Fenoldopam-Fenoldopam-Gs/β1/γ2
13.33Single7XJHIsoproterenol7XJH-β3-Isoproterenol-Gs/β1/γ2
13.33Single7XTC5-CT7XTC-5-HT7-5-CT-Gs/β1/γ2
13.33Single7YU4ONO-07405567YU4-LPA1-ONO-0740556
13.33Single8CICEtrumadenant8CIC-A2A-Etrumadenant-Na
13.33Single8GCML9026888GCM-EP4-L902688-Gi1/β1/γ2
13.33Single8IRTRotigotine8IRT-D3-Rotigotine-Gi1/β1/γ2
13.33Single8RLNLUF58348RLN-A2A-LUF5834
13.33Single8RW7StilSwitch18RW7-A2A-StilSwitch1-Na
13.33Single8RWXStilSwitch38RWX-A2A-StilSwitch3-Na
13.33Single8UGYMianserin8UGY-5-HT1E-Mianserin-Gi1/β1/γ1
13.33Single8UWLLisuride8UWL-5-HT2A-Lisuride-chim(NtGi2-Gs-CtGq)/β1/γ2
13.33Single8WC7ZH86678WC7-TA1-ZH8667-chim(NtGi1-Gs)/β1/γ2
13.33Single8XJLPGF2-alpha8XJL-FP-alpha-PGF2-α-chim(NtGi2-Gs-CtGq)/β1/γ2
13.33Single8YH5Riboprine8YH5-A3A-Riboprine-Gi1/β1/γ2
13.33Single8ZQEGPR15L(C11)8ZQE-GPR15-GPR15L(C11)-Gi1/β1/γ1
13.33Single9B9ZA1AKO9B9Z-CB1-A1AKO
13.33Consensus5ht5_onOrthosteric Ligand5ht5a_on
13.33Consensus5ht5a_onOrthosteric Ligand7X5H-5-HT5A-5-CT-Gi1/β1/γ2 7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/β1/γ2 7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/β1/γ2
13.33Consensus5ht6_onOrthosteric Ligand7XTB-5-HT6-Serotonin-Gs/β1/γ2 8JLZ-5-HT6-ST1936-Gs/β1/γ2
13.33Consensus5ht6_on_gpOrthosteric Ligand7XTB-5-HT6-Serotonin-Gs/β1/γ2 8JLZ-5-HT6-ST1936-Gs/β1/γ2
13.33Consensus5ht7_onOrthosteric Ligand7XTC-5-HT7-5-CT-Gs/β1/γ2
13.33Consensus5ht7_on_gpOrthosteric Ligand7XTC-5-HT7-5-CT-Gs/β1/γ2
13.33Consensusalicarboxylic_offOrthosteric Ligandsuccinate_off
13.33Consensusccr2_offOrthosteric Ligand6GPS-CCR2-MK0812
13.33Consensusnucleotide_offonOrthosteric Ligandnucleotide_off nucleotide_on
13.33Consensusnucleotide_offon_gpOrthosteric Ligandnucleotide_on_gp nucleotide_off
13.33Consensussuccinate_offOrthosteric Ligand6RNK-Succinate-NF-56-EJ40 6Z10-Succinate-PubChem 154585554
13.16Single7KH0AVP7KH0-V2-AVP-chim(NtGi1-Gs)/β1/γ2
13.16Single7W57Neuromedin-S7W57-NMUR2-Neuromedin-S-chim(NtGi1-Gs-CtGq)/β1/γ2
13.16Single7XK8Neuromedin-U-257XK8-NMUR2-Neuromedin-U-25-Gi1/β1/γ2
13.16Single8IEDA1LYA8IED-GPR156-A1LYA-Go/β1/γ2
13.16Consensusp2y_on_gpOrthosteric Ligandp2y1_on_gp p2y10_on_gp p2y12_on_gp
12.90Single2Y00Dobutamine2Y00-β1-Dobutamine
12.90Single4JKVTaladegib4JKV-SMO-Taladegib
12.90Single5T1APubChem 68764898; PubChem 120931705T1A-CCR2-PubChem 68764898; PubChem 12093170
12.90Single6E67BI1671076E67-β2-BI167107-Gs (fused)
12.90Single6GPXMK08126GPX-CCR2-MK0812
12.90Single6KPCPubChem 1459158896KPC-CB2-PubChem 145915889
12.90Single6LFMInterleukin-86LFM-CXCR2-Interleukin-8-Gi1/β1/γ2
12.90Single6M9TMisoprostol-FA6M9T-EP3-Misoprostol-FA
12.90Single7CKXA776367CKX-D1-A77636-Gs/β1/γ2
12.90Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
12.90Single7WC6LSD7WC6-5-HT2A-LSD
12.90Single7WIGL-054,2647WIG-SST2-L-054,264-Gi1/β1/γ2
12.90Single7YU3ONO-07405567YU3-LPA1-ONO-0740556-Gi1/β1/γ2
12.90Single8JXSPF-61428JXS-D1-PF-6142
12.90Single8K8JFenofibrate8K8J-CB1-Fenofibrate-chim(Gs-CtGq)/β1/γ2
12.90Single8VVEnorBNI8VVE-κ-norBNI-Gi1/β1/γ2
12.90Single8XQPCholesterol8XQP-TAS2R14-Cholesterol-Aristolochic acid A-Gt3/β1/γ1
12.90Single9IYBProstaglandin9IYB-DP2-Prostaglandin-A1D5Q-Gi1/β1/γ2
12.90Consensuscxcr2_on_gpOrthosteric Ligand6LFM-CXCR2-Interleukin-8-Gi1/β1/γ2
12.90Consensuslipid_onOrthosteric Ligandcannabinoid_on ffa_on lpl_on prostanoid_on leukotriene_on
12.90Consensuslipid_on_gpOrthosteric Ligandcannabinoid_on_gp ffa_on_gp lpl_on_gp prostanoid_on_gp leukotriene_on_gp
12.90Consensusnucleotide_onOrthosteric Ligandadenosine_on p2y_on
12.50Single3P0GBI1671073P0G-β2-BI167107
12.50Single3SN6BI1671073SN6-β2-BI167107-Gs/β1/γ2
12.50Single3ZEVNeurotensin3ZEV-NTS1-Neurotensin
12.50Single4BV0Neurotensin4BV0-NTS1-Neurotensin
12.50Single5V56TC1145V56-SMO-TC114
12.50Single5V57TC1145V57-SMO-TC114
12.50Single5XR8AM8415XR8-CB1-AM841
12.50Single5ZBHBMS-1938855ZBH-Y1-BMS-193885
12.50Single6J20Aprepitant6J20-NK1-Aprepitant
12.50Single6OS1TRV0266OS1-AT1-TRV026
12.50Single7B6WCyclazosin7B6W-α1b-Cyclazosin
12.50Single7E2ZAripiprazole7E2Z-5-HT1A-Aripiprazole-Gi1/β1/γ2
12.50Single7F1TMIP-1a7F1T-CCR5-MIP-1a
12.50Single7F58THIQ7F58-MC4-THIQ-Gs/β1/γ2
12.50Single7FEECP559407FEE-CB1-CP55940-ZCZ011
12.50Single7L0PNeurotensin7L0P-NTS1-Neurotensin-Gi1/β1/γ1
12.50Single7L0QNeurotensin7L0Q-NTS1-Neurotensin-Gi1/β1/γ1
12.50Single7TD1LPA7TD1-LPA1-LPA-Gi1/β1/γ2
12.50Single7WV9CP559407WV9-CB1-CP55940-ZCZ011-Gi2/β1/γ2
12.50Single7XBDGalanin7XBD-GAL2-Galanin-chim(NtGi2L-Gs-CtGq)/β1/γ2
12.50Single7XJLSpexin7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/β1/γ2
12.50Single7Y24Octreotide7Y24-SST2-Octreotide-Go/β1/γ2
12.50Single7Y67C089 peptide7Y67-C5a1-C089 peptide-Gi1/β1/γ2
12.50Single7YU5ONO-07405567YU5-LPA1-ONO-0740556-Gi1/β1/γ2
12.50Single8EFLSR170188EFL-μ-SR17018-Gi1/β1/γ2
12.50Single8FN1Neurotensin/Neuromedin-N8FN1-NTS1-Neurotensin/Neuromedin-N-chim(NtGi1-Go)/β1/γ2
12.50Single8HDOBAY 60-65838HDO-A2B-BAY 60-6583-Gs/β1/γ2
12.50Single8HPTC5a anaphylatoxin C-terminal peptide8HPT-C5a1-C5a anaphylatoxin C-terminal peptide-Go/β1/γ2
12.50Single8I2GCompound 7163408I2G-FSH-Glycoprotein hormones α chain-Compound 716340-Gs/β1/γ2
12.50Single8ID6Oleic acid8ID6-FFA4-Oleic acid-Gi1/β1/γ2
12.50Single8IUKPGF2-alpha8IUK-FP-alpha-PGF2-α-chim(NtGi1-Gs-CtGq)/β1/γ2
12.50Single8JLPRalmitaront8JLP-TA1-Ralmitaront-Gs/β1/γ2
12.50Single8JZPC5A anaphylatoxin8JZP-C5a1-C5A anaphylatoxin-Go/β1/γ2
12.50Single8WU1PubChem 1190256658WU1-CB1-PubChem 119025665-Arrestin2
12.50Single8XQTCholesterol8XQT-TAS2R14-Cholesterol-Cholesterol-Gi1/β1/γ1
12.50Single8XVEBQ30208XVE-ETB-BQ3020-chim(Gs-CtGq)/β1/γ2
12.50Single8XVLZibotentan8XVL-ETA-Zibotentan
12.50Single9BJKNAM9BJK-μ-Naloxone-NAM
12.50Single9IJDCarazolol9IJD-β3-Carazolol-chim(NtGi1-Gs)/β1/γ2
12.50Consensusgi_lpaOrthosteric Ligand7TD1-LPA1-LPA-Gi1/β1/γ2 7YU3-LPA1-ONO-0740556-Gi1/β1/γ2
12.50Consensuslpa_onOrthosteric Ligandlpa1_on
12.50Consensuslpa_on_gpOrthosteric Ligandlpa1_on_gp
12.50Consensusmotilin_onOrthosteric Ligand8IBU-Motilin-Erythromycin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
12.50Consensusneurotensin_onOrthosteric Ligandnts1_on
12.50Consensusnpy1_offOrthosteric Ligand5ZBH-Y1-BMS-193885 5ZBQ-Y1-UR-MK-299
12.50Consensusnpy_offOrthosteric Ligandnpy1_off npy2_off
12.50Consensusnts1_onOrthosteric Ligand6OSA-NTS1-JMV449-Gi1/β1/γ2 7L0S-NTS1-Neurotensin-Gi1/β1/γ1
12.50Consensustachykinin_offOrthosteric Ligandnk1_off
12.12Single4GRVNeurotensin-(8-13)4GRV-NTS1-Neurotensin-(8-13)
12.12Single4RWADIPP-NH24RWA-δ-DIPP-NH2
12.12Single6KPGAM8416KPG-CB1-AM841-Gi1/β1/γ2
12.12Single6KQICP559406KQI-CB1-CP55940-Org27569
12.12Single6MXTSalmeterol6MXT-β2-Salmeterol
12.12Single6OSAJMV4496OSA-NTS1-JMV449-Gi1/β1/γ2
12.12Single7L0SNeurotensin7L0S-NTS1-Neurotensin-Gi1/β1/γ1
12.12Single7L1UOrexin7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/β1/γ2
12.12Single7L1VPubChem 1554910097L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/β1/γ2
12.12Single7SUSPubChem 1227019087SUS-Apelin-PubChem 122701908
12.12Single7XJKGalanin7XJK-GAL2-Galanin-chim(NtGi2L-Gs-CtGq)/β1/γ2
12.12Single7XW9TRH7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/β1/γ2
12.12Single8H0QGastrin Releasing Peptide8H0Q-BB2-Gastrin Releasing Peptide-chim(NtGi1-Gs-CtGq)/β1/γ2
12.12Single8IBUErythromycin-A8IBU-Motilin-Erythromycin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
12.12Single8JJLOlodaterol8JJL-β2-Olodaterol
12.12Single8JPBNeurotensin-(8-13)8JPB-NTS1-Neurotensin-(8-13)-PubChem 118610427; GDP; Mg-Gq; GRK2
12.12Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/β1/γ2
12.12Single8W1VPubChem 1717162658W1V-β2-PubChem 171716265
12.12Single8XWMCXCL68XWM-CXCR2-CXCL6
12.12Consensuscb1_onOrthosteric Ligand6KPG-CB1-AM841-Gi1/β1/γ2 8K8J-CB1-Fenofibrate-chim(Gs-CtGq)/β1/γ2
12.12Consensusgalanin_onOrthosteric Ligandgal2_on gal1_on
12.12Consensusgalanin_on_gpOrthosteric Ligandgal2_on_gp gal1_on_gp
12.12Consensusgi_neurotensinOrthosteric Ligand6OSA-NTS1-JMV449-Gi1/β1/γ2 7L0S-NTS1-Neurotensin-Gi1/β1/γ1
12.12Consensusmotilin_on_gpOrthosteric Ligand8IBU-Motilin-Erythromycin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
12.12Consensusneurotensin_on_gpOrthosteric Ligandnts1_on_gp
12.12Consensusnts1_on_gpOrthosteric Ligand6OSA-NTS1-JMV449-Gi1/β1/γ2 7L0S-NTS1-Neurotensin-Gi1/β1/γ1
12.12Consensustrh_onOrthosteric Ligand7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/β1/γ2
12.12Consensustrh_on_gpOrthosteric Ligand7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/β1/γ2
12.00Single3PXOAll-trans-Retinal3PXO-Rhodopsin-All-trans-Retinal
12.00Single5DYSAll-trans-Retinal5DYS-Rhodopsin-All-trans-Retinal
12.00Single5MZJTheophylline5MZJ-A2A-Theophylline-Na
12.00Single8HQMNPGLY8HQM-GPR132-NPGLY-Gi1/β1/γ2
12.00Single8HVINOX-6-78HVI-GPR132-NOX-6-7-Gi1/β1/γ2
12.00Single8PWNTheophylline8PWN-A2A-Theophylline
11.76Single4NC3Ergotamine4NC3-5-HT2B-Ergotamine
11.76Single4RWSvMIP-II4RWS-CXCR4-vMIP-II
11.76Single6BQGErgotamine6BQG-5-HT2C-Ergotamine
11.76Single6DDFDamgo6DDF-μ-Damgo-Gi1/β1/γ2
11.76Single6K1QIRL25006K1Q-ETB-IRL2500
11.76Single6UP7Neurotensin6UP7-NTS1-Neurotensin-Arrestin2
11.76Single7MBYCholecystokinin-87MBY-CCKA-Cholecystokinin-8-chim(NtGi1L-Gs-CtGq)/β1/γ2
11.76Single8ID8TUG-8918ID8-FFA4-TUG-891-Gi1/β1/γ2
11.76Single8JPFNeurotensin8JPF-NTS1-Neurotensin-PubChem 118610427
11.76Single8WRZPubChem 1023367048WRZ-CB1-PubChem 102336704-Arrestin2
11.76Single8XWFCXCL38XWF-CXCR2-CXCL3
11.76Single8ZX4Lysophosphatidylinositol 8ZX4-GPR55-Lysophosphatidylinositol-chim(NtGi1-G13)/β1/γ2
11.76Single9GE3Lysophosphatidylinositol9GE3-GPR55-Lysophosphatidylinositol-chim(CtGi1-G13)/β1/γ2
11.76Single9IZFNKP9IZF-LPA1-NKP-Gi1/β1/γ2
11.63Single8ZJETAK-4488ZJE-Kiss1-TAK-448-chim(NtGi1-Gq)/β1/γ1
11.54Single3OE8IT1t3OE8-CXCR4-IT1t
11.54Single6OT025(S)-Epoxycholesterol6OT0-SMO-25(S)-Epoxycholesterol-Gi1/β1/γ2
11.54Single6XBM25(S)-Epoxycholesterol6XBM-SMO-25(S)-Epoxycholesterol-Gi1/β1/γ2
11.54Single8A2OTheophylline8A2O-A2A-Theophylline-Na
11.54Single8IWM2-Phenylethylamine8IWM-TA9-2-Phenylethylamine
11.54Single9CHUNoradrenaline9CHU-β2-Noradrenaline
11.43Single6OS9JMV4496OS9-NTS1-JMV449-Gi1/β1/γ2
11.43Single7AUESetmelanotide7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2
11.43Single7CX2PGE27CX2-EP2-PGE2-Gs/β1/γ2
11.43Single8H4IDoconexent8H4I-FFA4-Doconexent-chim(NtGi1-Gs)/β1/γ2
11.43Single8JBFSenktide8JBF-NK3-Senktide-chim(NtGi1-Gs-CtGq)/β1/γ2
11.43Single8XQJJN2418XQJ-Apelin-JN241
11.43Single8XX6CXCL88XX6-CXCR2-CXCL8-Go/β1/γ2
11.11Single2ZIY11-cis-Retinal2ZIY-Rhodopsin-11-cis-Retinal
11.11Single3UZAGTPL92363UZA-A2A-GTPL9236
11.11Single4IB4Ergotamine4IB4-5-HT2B-Ergotamine
11.11Single4XNWMRS25004XNW-P2Y1-MRS2500
11.11Single5WKTOctyl-Beta-D-Glucopyranoside5WKT-Rhodopsin-Octyl-β-D-Glucopyranoside-Gt(CT)
11.11Single6FK9PubChem 1324730366FK9-Rhodopsin-PubChem 132473036
11.11Single6FUFAll-trans-Retinal6FUF-Rhodopsin-All-trans-Retinal-Go
11.11Single6PWCNeurotensin6PWC-NTS1-Neurotensin-Arrestin2
11.11Single7D77Hydrocortisone7D77-ADGRG3-Hydrocortisone-Go/β1/γ2
11.11Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
11.11Single7F4ISHU91197F4I-MC1-SHU9119-chim(NtGi1-Gs)/β1/γ2
11.11Single7F54Afamelanotide7F54-MC4-Afamelanotide-Gs/β1/γ2
11.11Single7NA7Ghrelin-277NA7-Ghrelin-Ghrelin-27-Gi1/β1/γ2
11.11Single7W2ZGhrelin7W2Z-Ghrelin-Ghrelin-Go/β1/γ2
11.11Single8DPILorcaserin8DPI-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/β1/γ2
11.11Single8F76Propanoic acid8F76-OR51E2-Propanoic acid-Gs/β1/γ2
11.11Single8F7XNociceptin8F7X-NOP-Nociceptin-Gi1/β1/γ2
11.11Single8GHVAMG3158GHV-CB1-AMG315-Gi1/β1/γ2
11.11Single8ITFDMCHA8ITF-TA9-DMCHA-chim(NtGi1-Gs)/β1/γ2
11.11Single8IW72-Phenylethylamine8IW7-TA9-2-Phenylethylamine-chim(NtGi1-Gs)/β1/γ2
11.11Single8JXTHistamine8JXT-H4-Histamine-PO4-Gi1/β1/γ2
11.11Single8POKHistamine8POK-H2-Histamine-Gs/β1/γ2
11.11Single8XWNCXCL88XWN-CXCR2-CXCL8
11.11Single8ZCJPasireotide8ZCJ-SST5-Pasireotide-Gi1/β1/γ1
11.11Single9IV15alpha-DHT9IV1-ADGRD1-5α-DHT-chim(NtGi1-Gs)/β1/γ2
11.11Consensus5ht2_onOrthosteric Ligand5ht2b_on
11.11Consensus5ht2b_onOrthosteric Ligand7SRR-5-HT2B-LSD-chim(NtGi2L-Gs-CtGq)/β1/γ2
11.11Consensush2_on_gpOrthosteric Ligand8POK-H2-Histamine-Gs/β1/γ2
11.11Consensusmc4_onOrthosteric Ligand7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2 7F58-MC4-THIQ-Gs/β1/γ2 7F54-MC4-Afamelanotide-Gs/β1/γ2 7F53-MC4-α-MSH-Gs/β1/γ2 7F55-MC4-Bremelanotide-Gs/β1/γ2
11.11Consensusnk3_onOrthosteric Ligand8JBF-NK3-Senktide-chim(NtGi1-Gs-CtGq)/β1/γ2
11.11Consensusnk3_on_gpOrthosteric Ligand8JBF-NK3-Senktide-chim(NtGi1-Gs-CtGq)/β1/γ2
11.11Consensusnop_onOrthosteric Ligand8F7X-NOP-Nociceptin-Gi1/β1/γ2
11.11Consensusnop_on_gpOrthosteric Ligand8F7X-NOP-Nociceptin-Gi1/β1/γ2
11.11Consensusp2y1_offOrthosteric Ligand4XNW-P2Y1-MRS2500
10.81Single8K6OPro-neuropeptide-Y8K6O-Y1-Pro-neuropeptide-Y-Gi2/β1/γ1
10.81Single9EAINanobody AT2099EAI-AT1-Losartan-Nanobody AT209
10.81Consensusghrelin_onOrthosteric Ligand7NA7-Ghrelin-Ghrelin-27-Gi1/β1/γ2 7F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/β1/γ2 7NA8-Ghrelin-PubChem 178024-Gi1/β1/γ2
10.81Consensusghrelin_on_gpOrthosteric Ligand7NA7-Ghrelin-Ghrelin-27-Gi1/β1/γ2 7F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/β1/γ2 7NA8-Ghrelin-PubChem 178024-Gi1/β1/γ2
10.81Consensusmc4_on_gpOrthosteric Ligand7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2 7F58-MC4-THIQ-Gs/β1/γ2 7F54-MC4-Afamelanotide-Gs/β1/γ2 7F53-MC4-α-MSH-Gs/β1/γ2 7F55-MC4-Bremelanotide-Gs/β1/γ2
10.71Single3PBLEticlopride3PBL-D3-Eticlopride
10.71Single3VGAZM-2413853VGA-A2A-ZM-241385-Antibody
10.71Single6PGSGeraniol6PGS-Rhodopsin-Geraniol-Gt(CT)
10.71Single6PH7Nerol6PH7-Rhodopsin-Nerol-Gt(CT)
10.71Single6QNOAll-trans-Retinal6QNO-Rhodopsin-All-trans-Retinal-Gi1/β1/γ1
10.71Single7D76Beclomethasone7D76-ADGRG3-Beclomethasone-Go/β1/γ2
10.71Single7DFLHistamine7DFL-H1-Histamine-chim(NtGi1L-Gq)/β1/γ2
10.71Single7E2YSerotonin7E2Y-5-HT1A-Serotonin-Gi1/β1/γ2
10.71Single7SRQLSD7SRQ-5-HT2B-LSD
10.71Single7T96LY21196207T96-M2-Acetylcholine-LY2119620-Go/β1/γ2
10.71Single7TRPLY20332987TRP-M4-Iperoxo-LY2033298-Gi1/β1/γ2
10.71Single7VDHC48/807VDH-MRGPRX2-C48/80-Gi1/β1/γ2
10.71Single7XTASerotonin7XTA-5-HT4-Serotonin-Gi1/β1/γ2
10.71Single7YS6Serotonin7YS6-5-HT6-Serotonin-chim(NtGi1-Gs)/β1/γ2
10.71Single8HSCFab0468HSC-GPR20-Fab046-Gi1/β1/γ2
10.71Single8J6PCompound 9n8J6P-HCA2-Niacin-Compound 9n-Gi1/β1/γ2
10.71Single8JHYCompound 9n8JHY-HCA2-Compound 9n-Gi1/β1/γ2
10.71Single8JIICompound 9n8JII-HCA2-Niacin-Compound 9n-Gi1/β1/γ2
10.71Single8RWHStilSwitch28RWH-A2A-StilSwitch2-Na
10.71Single8UO4Constrained Epinephrine8UO4-β2-Constrained Epinephrine-GTP; Mg-Gs/β1/γ2
10.71Single8X2KOleic monoethanolamide8X2K-GPR3-Oleic monoethanolamide-chim(NtGi1-Gs)/β1/γ2
10.71Single8YN4Histamine8YN4-H2-Histamine-chim(NtGi1L-Gs-CtGq)/β1/γ2
10.71Single9EPQ11,20-Ethanoretinal9EPQ-Rhodopsin-11,20-Ethanoretinal-chim(Gi1-CtGq)/β1/γ2
10.71Single9IJEEpinephrine9IJE-β3-Epinephrine-chim(NtGi1-Gs)/β1/γ2
10.71Single9J5VCpY9J5V-LPA1-CpY-Gi1/β1/γ2
10.71Consensus5ht4_onOrthosteric Ligand7XTA-5-HT4-Serotonin-Gi1/β1/γ2
10.71Consensus5ht4_on_gpOrthosteric Ligand7XTA-5-HT4-Serotonin-Gi1/β1/γ2
10.71Consensusd3_offOrthosteric Ligand3PBL-D3-Eticlopride
10.71Consensush1_onOrthosteric Ligand7DFL-H1-Histamine-chim(NtGi1L-Gq)/β1/γ2
10.53Single7W55Neuromedin-U-257W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
10.53Single8WKZSBL-MC-318WKZ-MC4-SBL-MC-31
10.53Consensusnmur2_onOrthosteric Ligand7W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
10.53Consensusnmur2_on_gpOrthosteric Ligand7W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
10.34Single3PWHZM-2413853PWH-A2A-ZM-241385
10.34Single5OLVLUAA410635OLV-A2A-LUAA41063-Na
10.34Single6FKBPubChem 1324730386FKB-Rhodopsin-PubChem 132473038
10.34Single6LFOInterleukin-86LFO-CXCR2-Interleukin-8-Gi1/β1/γ2
10.34Single6ME2Ramelteon6ME2-MT1-Ramelteon
10.34Single6NWEOctyl-Beta-D-Glucopyranoside6NWE-Rhodopsin-Octyl-β-D-Glucopyranoside-Gt(CT)
10.34Single6RNKNF-56-EJ406RNK-Succinate-NF-56-EJ40
10.34Single6WWZCCL206WWZ-CCR6-CCL20-Go/β1/γ2
10.34Single7F1ODopamine7F1O-D1-Dopamine-GDP; Mg-Gs/β1/γ2
10.34Single7F8ULintitript7F8U-CCKA-Lintitript
10.34Single7F8YDevazepide7F8Y-CCKA-Devazepide
10.34Single7LJDDopamine7LJD-D1-Dopamine-Mevidalen-Gs/β1/γ1
10.34Single7SRRLSD7SRR-5-HT2B-LSD-chim(NtGi2L-Gs-CtGq)/β1/γ2
10.34Single7SRSLSD7SRS-5-HT2B-LSD-Arrestin2
10.34Single7VDLCortistatin-147VDL-MRGPRX2-Cortistatin-14-Gi1/β1/γ2
10.34Single7VV5C48/807VV5-MRGPRX2-C48/80-Gi1/β1/γ2
10.34Single7X2CFenoldopam7X2C-D1-Fenoldopam-Fenoldopam-Gs/β1/γ2
10.34Single7X5H5-CT7X5H-5-HT5A-5-CT-Gi1/β1/γ2
10.34Single7XJJGalanin7XJJ-GAL1-Galanin-Go/β1/γ2
10.34Single7XRRLemborexant7XRR-OX2-Lemborexant
10.34Single8H8JLodoxamide8H8J-GPR35-Lodoxamide-Ca-chim(NtGi1L-G13)/β1/γ2
10.34Single8RW4AzoSwitch28RW4-A2A-AzoSwitch2-Na
10.34Single8RWEStilSwitch48RWE-A2A-StilSwitch4-Na
10.34Single8TZQL-Dopamine8TZQ-D2-L-Dopamine-Go/β1/γ2
10.34Single8U4PAMD31008U4P-CXCR4-AMD3100-Cholesterol-Gi1/β1/γ2
10.34Single8U4SREGN7663-Fab8U4S-CXCR4-REGN7663-Fab
10.34Single8U4TREGN7663-Fab8U4T-CXCR4-REGN7663-Fab
10.34Single8U8FPalmitic Acid8U8F-GPR3-Palmitic Acid-Gs/β1/γ2
10.34Single8XXXCXCL68XXX-CXCR2-CXCL6-Go/β1/γ2
10.34Single9FUPIstradefylline9FUP-A2A-Istradefylline-Na
10.34Consensus5ht2_on_gpOrthosteric Ligand5ht2b_on_gp
10.34Consensus5ht2b_on_gpOrthosteric Ligand7SRR-5-HT2B-LSD-chim(NtGi2L-Gs-CtGq)/β1/γ2
10.34Consensus5ht_onOrthosteric Ligand5ht1_on 5ht2_on 5ht4_on 5ht5_on 5ht6_on 5ht7_on
10.34Consensusccr6_onOrthosteric Ligand6WWZ-CCR6-CCL20-Go/β1/γ2
10.34Consensusccr6_on_gpOrthosteric Ligand6WWZ-CCR6-CCL20-Go/β1/γ2
10.34Consensuscxcr1_onOrthosteric Ligand8IC0-CXCR1-Interleukin-8-Gi1/β1/γ2
10.34Consensusgs_5htOrthosteric Ligand7XTC-5-HT7-5-CT-Gs/β1/γ2 7XTB-5-HT6-Serotonin-Gs/β1/γ2 8JLZ-5-HT6-ST1936-Gs/β1/γ2 7XT8-5-HT4-Serotonin-Gs/β1/γ2
10.34Consensusp2y1_onOrthosteric Ligand7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/β1/γ2
10.00Single3RZECidoxepin3RZE-H1-Cidoxepin
10.00Single6FK8PubChem 1324730356FK8-Rhodopsin-PubChem 132473035
10.00Single6IQLL7458706IQL-D4-L745870
10.00Single6ME42-Iodomelatonin6ME4-MT1-2-Iodomelatonin
10.00Single6PT0WIN 55212-26PT0-CB2-WIN 55212-2-Gi1/β1/γ2
10.00Single6TPKRetosiban6TPK-OT-Retosiban
10.00Single6TPNHTL66416TPN-OX2-HTL6641
10.00Single6WJCMuscarinic toxin 76WJC-M1-Atropine-Muscarinic toxin 7
10.00Single6ZDVChromone 5d6ZDV-A2A-Chromone 5d-Na
10.00Single7C2EPubChem 1490507997C2E-GLP-1-PubChem 149050799-Gs/β1/γ2
10.00Single7F24Dopamine7F24-D1-Dopamine-GDP-Gs/β1/γ2
10.00Single7F9YGhrelin-287F9Y-Ghrelin-Ghrelin-28-chim(NtGi1-Gs-CtGq)/β1/γ2
10.00Single7UTZPubChem 6440787UTZ-TSH-TR1402-PubChem 644078-Gs/β1/γ2
10.00Single7VV6C48/807VV6-MRGPRX2-C48/80
10.00Single7WVUfMLF7WVU-FPR1-ALX-fMLF-Gi1/β1/γ2
10.00Single8IODPG-9018IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/β1/γ2
10.00Single8K2WAMG4878K2W-CXCR3-AMG487
10.00Single8V6UPubChem 1713924568V6U-5-HT2A-PubChem 171392456-chim(NtGi2-Gs-CtGq)/β1/γ2
10.00Single8VVGGB188VVG-κ-GB18-Gi1/β1/γ2
10.00Single8X7ATreprostinil8X7A-I2-Treprostinil-Gs/β1/γ2
10.00Single8Y53MK50468Y53-BB3-MK5046-chim(NtGi1-Gs-CtGq)/β1/γ2
10.00Single8Y62C16:0 Ceramide8Y62-FPR2-ALX-C16:0 Ceramide-Gi1/β1/γ2
10.00Single8ZMGPimavanserin8ZMG-5-HT2A-Pimavanserin
10.00Single9BJKNaloxone9BJK-μ-Naloxone-NAM
10.00Consensuscxcr3_offOrthosteric Ligand8K2W-CXCR3-AMG487
10.00Consensusot_offOrthosteric Ligand6TPK-OT-Retosiban
10.00Consensusvasop-oxy_offOrthosteric Ligandot_off
9.68Single2Y02Carmoterol2Y02-β1-Carmoterol
9.68Single4QIMANTA XV4QIM-SMO-ANTA XV
9.68Single5ZKPForopafant (SR27417)5ZKP-PAF-Foropafant (SR27417)
9.68Single6DRXLisuride6DRX-5-HT2B-Lisuride
9.68Single6ORVTT-OAD26ORV-GLP-1-TT-OAD2-Gs/β1/γ2
9.68Single7F83PF-051904577F83-Ghrelin-PF-05190457
9.68Single7JOZVFP7JOZ-D1-VFP-Gs/β1/γ2
9.68Single7SK8CXCL127SK8-ACKR3-CXCL12-CCX662
9.68Single7SQOTAK-9257SQO-OX2-TAK-925-Gi1/β1/γ2
9.68Single7TRQVU04671547TRQ-M4-Iperoxo-VU0467154-Gi1/β1/γ2
9.68Single7VH0Ramelteon7VH0-MT2-Ramelteon-Gi1/β1/γ1
9.68Single7WQ3Galanin7WQ3-GAL1-Galanin-Gi1/β1/γ2
9.68Single8EFQDamgo8EFQ-μ-Damgo-Gi1/β1/γ2
9.68Single8IC0Interleukin-88IC0-CXCR1-Interleukin-8-Gi1/β1/γ2
9.68Single8KFYZK-7563268KFY-CCR8-ZK-756326-Gi1/β1/γ2
9.68Single8TH3AT118-H Nanobody8TH3-AT1-AT118-H Nanobody
9.68Single8X9TAP5038X9T-ADGRD1-AP503-chim(NtGi1-Gs)/β1/γ2
9.68Single9IMATalquetamab9IMA-GPRC5D-Talquetamab
9.68Consensuscck_offOrthosteric Ligandccka_off
9.68Consensusccka_offOrthosteric Ligand7F8Y-CCKA-Devazepide 7F8U-CCKA-Lintitript
9.68Consensuscxcr1_on_gpOrthosteric Ligand8IC0-CXCR1-Interleukin-8-Gi1/β1/γ2
9.68Consensusgal1_onOrthosteric Ligand7WQ3-GAL1-Galanin-Gi1/β1/γ2
9.68Consensusgal1_on_gpOrthosteric Ligand7WQ3-GAL1-Galanin-Gi1/β1/γ2
9.68Consensusgi_galaninOrthosteric Ligand7WQ3-GAL1-Galanin-Gi1/β1/γ2
9.68Consensusgi_orexinOrthosteric Ligand7SQO-OX2-TAK-925-Gi1/β1/γ2
9.38Single4RWDDIPP-NH24RWD-δ-DIPP-NH2-Na
9.38Single5XPRBosentan5XPR-ETB-Bosentan
9.38Single6HLPNetupitant6HLP-NK1-Netupitant
9.38Single6RZ4Pranlukast6RZ4-CysLT1-Pranlukast-Na
9.38Single7EUOfMLF7EUO-FPR1-ALX-fMLF-Gi1/β1/γ2
9.38Single7VV0PAMP-127VV0-MRGPRX2-PAMP-12
9.38Single7VV4Cortistatin-147VV4-MRGPRX2-Cortistatin-14
9.38Single7Y26Octreotide7Y26-SST2-Octreotide-chim(NtGi2L-Gs-CtGq)/β1/γ2
9.38Single8ID4Linoleic acid8ID4-FFA4-Linoleic acid-Gi1/β1/γ2
9.38Single8KFXLMD-0098KFX-CCR8-LMD-009-Gi1/β1/γ2
9.38Single8SZICa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZI-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi3/β1/γ2
9.38Single8TH4AT118-L Nanobody8TH4-AT1-Losartan-AT118-L Nanobody
9.38Single9DQJEP-39459DQJ-MRGPRD-EP-3945-chim(NtGi1-Gs-CtGq)/β1/γ2
9.38Single9EAHNanobody AT2099EAH-AT1-Olmesartan-Nanobody AT209
9.38Consensuslpa1_onOrthosteric Ligand7TD1-LPA1-LPA-Gi1/β1/γ2 7YU3-LPA1-ONO-0740556-Gi1/β1/γ2
9.38Consensuslpa1_on_gpOrthosteric Ligand7TD1-LPA1-LPA-Gi1/β1/γ2 7YU3-LPA1-ONO-0740556-Gi1/β1/γ2
9.09Single3PDSHydroxybenzylisoproterenol3PDS-β2-Hydroxybenzylisoproterenol
9.09Single4IAQDihydroergotamine4IAQ-5-HT1B-Dihydroergotamine
9.09Single5XRAAM115425XRA-CB1-AM11542
9.09Single6DDEDamgo6DDE-μ-Damgo-Gi1/β1/γ2
9.09Single6E59L-7607356E59-NK1-L-760735
9.09Single7M8W15r-Methyl-Prostaglandin D27M8W-DP2-15r-Methyl-Prostaglandin D2-Na
9.09Single7R0CAVP7R0C-V2-AVP-Arrestin2
9.09Single7S8MCortistatin-147S8M-MRGPRX2-Cortistatin-14-Gi1/β1/γ2
9.09Single7SK7CXCL127SK7-ACKR3-CXCL12-CCX662
9.09Single7XAVLanreotide7XAV-SST2-Lanreotide-Gi1/β1/γ2
9.09Single8FMZNeurotensin/Neuromedin-N8FMZ-NTS1-Neurotensin/Neuromedin-N-chim(NtGi2L-Gs-CtGq)/β1/γ2
9.09Single8GDBPGE28GDB-EP4-PGE2-Gs/β1/γ2
9.09Single8GUSHU-3088GUS-CB2-HU-308-Gi1/β1/γ2
9.09Single8JSRAnamorelin8JSR-Ghrelin-Anamorelin-chim(NtGi1-Gs-CtGq)/β1/γ2
9.09Single8XX7CXCL58XX7-CXCR2-CXCL5-Go/β1/γ2
8.82Single7WQ4Galanin7WQ4-GAL2-Galanin-chim(NtGi1-Gs-CtGq)/β1/γ2
8.82Single7XW6ML1097XW6-TSH-M22 Fab-ML109-Gs/β1/γ2
8.82Single8U26Protachykinin-18U26-NK1-Protachykinin-1-Gs/β1/γ2
8.82Single8XQJJN2418XQJ-Apelin-JN241
8.82Single8XWACXCL18XWA-CXCR2-CXCL1
8.82Single8XWSCXCL58XWS-CXCR2-CXCL5
8.82Single8XX3CXCL38XX3-CXCR2-CXCL3-Go/β1/γ2
8.82Single8ZPLHF511168ZPL-CXCR4-HF51116-Cholesterol
8.57Single7CX4Evatanepag7CX4-EP2-Evatanepag-Gs/β1/γ2
8.57Single7P00Substance-P7P00-NK1-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
8.57Single8T3OTUG-8918T3O-FFA4-TUG-891-2Y5-chim(NtGi2L-Gs-CtGq)/β1/γ2
8.57Single8XWVCXCL18XWV-CXCR2-CXCL1-Go/β1/γ2
8.57Consensusnk1_onOrthosteric Ligand7P00-NK1-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
8.57Consensusnk1_on_gpOrthosteric Ligand7P00-NK1-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
8.57Consensusnk2_onOrthosteric Ligand7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
8.33Single6KNMJN241-96KNM-Apelin-JN241-9
8.33Single7F9ZGHRP-67F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/β1/γ2
8.33Single7RMHSubstance-P7RMH-NK1-Substance-P-Gs/β1/γ2
8.33Single7S8LCortistatin-147S8L-MRGPRX2-Cortistatin-14-chim(NtGi2L-Gs-CtGq)/β1/γ2
8.33Single8F7REndomorphin8F7R-μ-Endomorphin-Gi1/β1/γ2
8.33Single8Z74Agonistic antibody8Z74-Apelin-Agonistic antibody
8.33Consensuskiss1_onOrthosteric Ligand8ZJD-Kiss1-Kisspeptin-10-chim(NtGi1-Gq)/β1/γ1
8.33Consensuskisspeptin_onOrthosteric Ligandkiss1_on
8.11Single7CX3Taprenepag7CX3-EP2-Taprenepag-Gs/β1/γ2
8.11Single7VLACCL15(27-92)7VLA-CCR1-CCL15(27-92)-Gi1/β1/γ2
8.11Single7W56Neuromedin-S7W56-NMUR1-Neuromedin-S-chim(NtGi1-Gs-CtGq)/β1/γ2
8.11Single8INRAlpha-MSH8INR-MC5-α-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
8.11Single8KIGSHU91198KIG-MC3-SHU9119-Ca
8.11Single8WKYPG-9348WKY-MC4-PG-934
8.11Single8ZJDKisspeptin-108ZJD-Kiss1-Kisspeptin-10-chim(NtGi1-Gq)/β1/γ1
8.11Consensusccr1_onOrthosteric Ligand7VLA-CCR1-CCL15(27-92)-Gi1/β1/γ2
8.11Consensusccr1_on_gpOrthosteric Ligand7VLA-CCR1-CCL15(27-92)-Gi1/β1/γ2
8.11Consensusgq_kisspeptinOrthosteric Ligand8ZJD-Kiss1-Kisspeptin-10-chim(NtGi1-Gq)/β1/γ1
8.11Consensuskiss1_on_gpOrthosteric Ligand8ZJD-Kiss1-Kisspeptin-10-chim(NtGi1-Gq)/β1/γ1
8.11Consensuskisspeptin_on_gpOrthosteric Ligandkiss1_on_gp
8.00Single4A4MAll-trans-Retinal4A4M-Rhodopsin-All-trans-Retinal-Gt(CT)
8.00Single5EN0All-trans-Retinal5EN0-Rhodopsin-All-trans-Retinal-Gt(CT)
8.00Single5MZPCaffeine5MZP-A2A-Caffeine-Na
8.00Single8WCBCyclohexylammonium Ion8WCB-TA1-Cyclohexylammonium Ion-chim(NtGi1-Gs-CtGq)/β1/γ2
8.00Single8WCCCyclohexylammonium Ion8WCC-TA1-Cyclohexylammonium Ion
8.00Single9IVMLSN33188399IVM-GLP-1-GLP-1 (Truncated)-LSN3318839-chim(NtGi1-Gs)/β2/γ2
7.89Single7PIVSetmelanotide7PIV-MC4-Setmelanotide-Gs/β1/γ2
7.89Single8KH5Lysophosphatidylserine8KH5-GPR174-Lysophosphatidylserine-Gs/β1/γ2
7.89Consensusmc5_onOrthosteric Ligand8INR-MC5-α-MSH-Ca-chim(NtGi1-Gs)/β1/γ2 8IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/β1/γ2
7.89Consensustachykinin_on_gpOrthosteric Ligandnk1_on_gp nk2_on_gp nk3_on_gp
7.69Single6VCBLSN31604406VCB-GLP-1-GLP-1-LSN3160440-Gs/β1/γ2
7.69Single6W25SHU91196W25-MC4-SHU9119-Ca
7.69Single7V68PubChem 576644067V68-M4-Iperoxo-PubChem 57664406-Gi1/β1/γ2
7.69Single7XKEBeta-Hydroxyandrosterone7XKE-ADGRG2-β-Hydroxyandrosterone-chim(NtGi1-Gs)/β1/γ2
7.69Single8HS2Fab0468HS2-GPR20-Fab046
7.69Single8K6MNeuropeptide-Y8K6M-Y1-Neuropeptide-Y-Gi2/β1/γ1
7.69Single8X9S5alpha-DHT8X9S-ADGRD1-5α-DHT-chim(NtGi1-Gs)/β1/γ2
7.69Single9IV25alpha-DHT9IV2-ADGRD1-5α-DHT-chim(NtGi1-Gs)/β1/γ2
7.69Consensusnpy1_onOrthosteric Ligand8K6M-Y1-Neuropeptide-Y-Gi2/β1/γ1
7.69Consensusnpy1_on_gpOrthosteric Ligand8K6M-Y1-Neuropeptide-Y-Gi2/β1/γ1
7.50Consensusmc5_on_gpOrthosteric Ligand8INR-MC5-α-MSH-Ca-chim(NtGi1-Gs)/β1/γ2 8IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/β1/γ2
7.50Consensustachykinin_onOrthosteric Ligandnk1_on nk2_on nk3_on
7.41Single3RFMCaffeine3RFM-A2A-Caffeine
7.41Single6OY9All-trans-Retinal6OY9-Rhodopsin-All-trans-Retinal-Gt/β1/γ1
7.41Single6TQ9SB-4081246TQ9-OX1-SB-408124
7.41Single8U4QREGN7663-Fab8U4Q-CXCR4-REGN7663-Fab-Cholesterol-Gi1/β1/γ2
7.41Consensusgs_histamineOrthosteric Ligand8POK-H2-Histamine-Gs/β1/γ2
7.41Consensush2_onOrthosteric Ligand8POK-H2-Histamine-Gs/β1/γ2
7.41Consensusp2y_offOrthosteric Ligandp2y1_off
7.32Single7P02Protachykinin-17P02-NK1-Protachykinin-1-chim(NtGi1-Gs)/β1/γ2
7.32Single7XV3Lysophosphatidylserine7XV3-GPR174-Lysophosphatidylserine-chim(NtGi1-Gs)/β1/γ2
7.14Single6D32Cyclopamine6D32-SMO-Cyclopamine-Cyclopamine
7.14Single6ME5Agomelatine6ME5-MT1-Agomelatine
7.14Single6OIKLY21196206OIK-M2-Iperoxo-LY2119620-chim(NtGi1-Go)/β1/γ2
7.14Single8J6QCompound 9n8J6Q-HCA2-β-Hydroxybutyrate-Compound 9n-Gi1/β1/γ2
7.14Single8JPSCCL78JPS-ACKR1-CCL7
6.98Consensusp2y10_on_gpOrthosteric Ligand8KGG-P2Y10-LPS-chim(NtGi2-G13)/β1/γ2
6.90Single6HLLCP999946HLL-NK1-CP99994
6.90Single6I9K9-cis-Retinal6I9K-Rhodopsin-9-cis-Retinal
6.90Single6TQ4PubChem 160468446TQ4-OX1-PubChem 16046844-Na
6.90Single7VUIJNJ-635330547VUI-GPR139-JNJ-63533054-GTP-chim(Gs-CtGq)/β1/γ2
6.90Single7XTBSerotonin7XTB-5-HT6-Serotonin-Gs/β1/γ2
6.90Single8A2PLUAA470708A2P-A2A-LUAA47070-Na
6.90Single8EF6Morphine8EF6-μ-Morphine-Gi1/β1/γ2
6.90Single8FX5Xanomeline8FX5-M4-Xanomeline-Xanomeline-Gi1/β1/γ2
6.90Single8YN2Histamine8YN2-H1-Histamine-chim(NtGi1L-Gs-CtGq)/β1/γ2
6.90Single9L3ZLRH7-C29L3Z-CML1-LRH7-C2
6.90Consensusgq_nucleotideOrthosteric Ligandgq_p2y
6.90Consensusgq_p2yOrthosteric Ligand7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/β1/γ2
6.82Single8KGGLPS8KGG-P2Y10-LPS-chim(NtGi2-G13)/β1/γ2
6.67Single4K5YCP-3763954K5Y-CRF1-CP-376395
6.67Single5OLHVipadenant5OLH-A2A-Vipadenant-Na
6.67Single6DS0Ly2660976DS0-5-HT2B-Ly266097
6.67Single6ME9Ramelteon6ME9-MT2-Ramelteon
6.67Single6TQ6PubChem 1457142836TQ6-OX1-PubChem 145714283
6.67Single7S8PMS471347S8P-MRGPRX4-MS47134-chim(NtGi2L-Gs-CtGq)/β1/γ2
6.67Single7T6SPubChem 247763417T6S-FPR2-ALX-PubChem 24776341-Gi1/β1/γ2
6.67Single7TUZ7-alpha,25-dihydroxycholesterol7TUZ-GPR183-7-α,25-dihydroxycholesterol-Gi1/β1/γ2
6.67Single7W0MPubChem 1227019087W0M-Apelin-PubChem 122701908-Gi1/β1/γ2
6.67Single7X2FDopamine7X2F-D1-Dopamine-Mevidalen-Gs/β1/γ2
6.67Single8DWHPubChem 1390305318DWH-MRGPRX1-PubChem 139030531-chim(NtGi2L-Gs-CtGq)/β1/γ2
6.67Single8YUTAmthamine8YUT-H2-Amthamine-Gs/β1/γ2
6.45Single3REYXAC3REY-A2A-XAC
6.45Single8K9LDamgo8K9L-μ-Damgo-VV9-Gi3/β1/γ1
6.25Single4Z9GCP-3763954Z9G-CRF1-CP-376395
6.25Single5UIGCmpd-15UIG-A2A-Cmpd-1
6.25Single7NA8PubChem 1780247NA8-Ghrelin-PubChem 178024-Gi1/β1/γ2
6.25Single8GTIBMK-C2058GTI-CRF1-BMK-C205
6.25Single8KEXDCA-3P8KEX-MRGPRX4-DCA-3P
6.25Single8ZBEOctreotide8ZBE-SST5-Octreotide-Gi1/β1/γ1
6.25Single9IYAONO-97105319IYA-GPR55-ONO-9710531
6.06Single5ZBQUR-MK-2995ZBQ-Y1-UR-MK-299
6.06Single7VFXfMLF7VFX-FPR1-ALX-fMLF-Gi1/β1/γ2
6.06Single8GTGBMK-I1528GTG-CRF1-BMK-I152
6.06Single8IZ4Lysophosphatidylserine8IZ4-GPR34-Lysophosphatidylserine-Gi1/β1/γ2
6.06Single9DQHEP-28259DQH-MRGPRD-EP-2825-chim(NtGi1-Gs-CtGq)/β1/γ2
6.06Consensusfpr1-alx_onOrthosteric Ligand7VFX-FPR1-ALX-fMLF-Gi1/β1/γ2
6.06Consensusfpr1-alx_on_gpOrthosteric Ligand7VFX-FPR1-ALX-fMLF-Gi1/β1/γ2
5.88Single6Z8NSRI-98296Z8N-NTS1-SRI-9829
5.88Single7XWONeurokinin-A7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
5.88Single8JBGNeurokinin-B8JBG-NK3-Neurokinin-B-chim(NtGi1-Gs-CtGq)/β1/γ2
5.88Single9GE2ML1849GE2-GPR55-ML184-Cholesterol-chim(CtGi1-G13)/β1/γ2
5.88Consensuscyslt1_offOrthosteric Ligand6RZ5-CysLT1-Zafirlukast-Na 6RZ4-CysLT1-Pranlukast-Na
5.88Consensusffa2_onOrthosteric Ligand8J22-FFA2-TUG-1375-Gi1/β1/γ2
5.88Consensusnk2_on_gpOrthosteric Ligand7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
5.71Single6RZ7ONO-25703666RZ7-CysLT2-ONO-2570366
5.71Single7F55Bremelanotide7F55-MC4-Bremelanotide-Gs/β1/γ2
5.71Single8DWCProenkephalin-A8DWC-MRGPRX1-Proenkephalin-A-chim(NtGi2L-Gs-CtGq)/β1/γ2
5.71Single8GTMBMK-C2038GTM-CRF1-BMK-C203
5.71Single8WRBLysophosphatidylserine8WRB-GPR34-Lysophosphatidylserine-Gi1/β1/γ2
5.71Consensusffa2_on_gpOrthosteric Ligand8J22-FFA2-TUG-1375-Gi1/β1/γ2
5.56Single6RZ9ONO-27703726RZ9-CysLT2-ONO-2770372
5.56Single7PIUSetmelanotide7PIU-MC4-Setmelanotide-Gs/β1/γ2
5.56Single7QVMOxytocin7QVM-OT-Oxytocin-chim(NtGi1-Go-CtGq)/β1/γ2
5.56Consensuscyslt2_offOrthosteric Ligand6RZ7-CysLT2-ONO-2570366 6RZ8-CysLT2-ONO-2080365 6RZ9-CysLT2-ONO-2770372
5.41Single6RZ6ONO-25703666RZ6-CysLT2-ONO-2570366
5.41Single7RMGSubstance-P7RMG-NK1-Substance-P-chim(Gs-CtGq)/β1/γ2
5.41Single8J22TUG-13758J22-FFA2-TUG-1375-Gi1/β1/γ2
5.41Single8SAI1-Oleoyl-2-Hydroxy-Sn-Glycero-3-Phospho-L-Serine8SAI-GPR34-1-Oleoyl-2-Hydroxy-Sn-Glycero-3-Phospho-L-Serine-Gi1/β1/γ2
5.41Single8Z74Agonistic antibody8Z74-Apelin-Agonistic antibody
5.41Single9ITBLPA9ITB-LPA6-LPA-chim(NtGi1-Gs-CtGq)/β1/γ2
5.26Single8DWGProenkephalin-A8DWG-MRGPRX1-Proenkephalin-A-ML382-chim(NtGi2L-Gs-CtGq)/β1/γ2
5.26Single8IZBLysophosphatidylserine8IZB-GPR174-Lysophosphatidylserine-Gs/β1/γ2
5.26Single8XBHS3E-LysoPS8XBH-GPR34-S3E-LysoPS-Gi1/β1/γ2
5.13Single7RMISubstance-P7RMI-NK1-Substance-P-chim(Gs-CtGq)/β1/γ2
5.13Single7SHEPI; PE7SHE-GPR158-PI; PE
5.13Single7SHFPI; PE7SHF-GPR158-PI; PE-B5; RGS7
5.13Single8IOCGamma-MSH8IOC-MC3-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
5.13Single8JBHSubstance-P8JBH-NK3-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
5.00Consensusmc3_onOrthosteric Ligand8IOC-MC3-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
5.00Consensusmc3_on_gpOrthosteric Ligand8IOC-MC3-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
4.76Consensusp2y10_onOrthosteric Ligand8KGG-P2Y10-LPS-chim(NtGi2-G13)/β1/γ2
4.35Single6D32Cyclopamine6D32-SMO-Cyclopamine-Cyclopamine
4.35Single6D35Cholesterol6D35-SMO-Cholesterol
4.35Single6N51Quisqualate6N51-mGlu5; mGlu5-Quisqualate
4.35Single6N51Quisqualate6N51-mGlu5; mGlu5-Quisqualate
4.35Single6UO8SKF975416UO8-GABAB1, GABAB2-SKF97541-GS39783
4.35Single6UO9SKF975416UO9-GABAB1, GABAB2-SKF97541
4.35Single6W2XPubChem 53110426W2X-GABAB1, GABAB2-PubChem 5311042-PubChem 23727970
4.35Single6W2YPubChem 53110426W2Y-GABAB1; GABAB1-PubChem 5311042-PubChem 23727970
4.35Single6W2YPubChem 53110426W2Y-GABAB1; GABAB1-PubChem 5311042-PubChem 23727970
4.35Single7C7QBaclofen7C7Q-GABAB1, GABAB2-Baclofen-PubChem 7023848
4.35Single7C7SCGP546267C7S-GABAB1, GABAB2-CGP54626
4.35Single7CUMCGP546267CUM-GABAB1, GABAB2-CGP54626-Phospholipid
4.35Single7DD5Ca7DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
4.35Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
4.35Single7DD5Ca7DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
4.35Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
4.35Single7DGEQuisqualate7DGE-mGlu1; mGlu1-Quisqualate
4.35Single7DTTCa7DTT-CaS-Ca-Ca
4.35Single7DTTCa7DTT-CaS-Ca-Ca
4.35Single7DTUTryptophan7DTU-CaS-Tryptophan
4.35Single7DTUTryptophan7DTU-CaS-Tryptophan
4.35Single7DTVCa7DTV-CaS-Ca-Ca; Tryptophan
4.35Single7DTVCa; Tryptophan7DTV-CaS-Ca-Ca; Tryptophan
4.35Single7DTVCa7DTV-CaS-Ca-Ca; Tryptophan
4.35Single7DTVCa; Tryptophan7DTV-CaS-Ca-Ca; Tryptophan
4.35Single7E6TCa7E6T-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
4.35Single7E6TCa; Ca; Cyclomethyltryptophan; PO47E6T-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
4.35Single7E6TCa7E6T-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
4.35Single7E6TCa; Ca; Cyclomethyltryptophan; PO47E6T-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
4.35Single7E9GEglumetad7E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/β1/γ2
4.35Single7E9GEglumetad7E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/β1/γ2
4.35Single7E9HPhosphoserine7E9H-mGlu4; mGlu4-Phosphoserine-Gi3/β1/γ2
4.35Single7E9HPhosphoserine7E9H-mGlu4; mGlu4-Phosphoserine-Gi3/β1/γ2
4.35Single7EB2Baclofen7EB2-GABAB2; GABAB1-Baclofen-rac-BHFF-Gi1/β1/γ2
4.35Single7EPBEglumetad7EPB-mGlu2; mGlu2-Eglumetad
4.35Single7EPBEglumetad7EPB-mGlu2; mGlu2-Eglumetad
4.35Single7FD8Quisqualate7FD8-mGlu5; mGlu5-Quisqualate
4.35Single7FD8Quisqualate7FD8-mGlu5; mGlu5-Quisqualate
4.35Single7FD9LY3414957FD9-mGlu5; mGlu5-LY341495
4.35Single7FD9LY3414957FD9-mGlu5; mGlu5-LY341495
4.35Single7FIHhCG7FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/β1/γ2
4.35Single7FIIhCG7FII-LH-hCG-chim(NtGi1-Gs)/β1/γ2
4.35Single7M3ECa; Ca; Tryptophan; NPS-21437M3E-CaS-Ca; Ca; Tryptophan; NPS-2143
4.35Single7M3ECa; Ca; Tryptophan; NPS-21437M3E-CaS-Ca; Ca; Tryptophan; NPS-2143
4.35Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
4.35Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
4.35Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
4.35Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
4.35Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
4.35Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
4.35Single7MTQLY3414957MTQ-mGlu2; mGlu2-LY341495
4.35Single7MTQLY3414957MTQ-mGlu2; mGlu2-LY341495
4.35Single7MTRGlutamate7MTR-mGlu2; mGlu2-Glutamate-ADX55164
4.35Single7MTRGlutamate7MTR-mGlu2; mGlu2-Glutamate-ADX55164
4.35Single7MTSGlutamate7MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/β1/γ2
4.35Single7MTSGlutamate7MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/β1/γ2
4.35Single7SILCa7SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
4.35Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
4.35Single7SILCa7SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
4.35Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
4.35Single7SIMCa7SIM-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
4.35Single7SIMCa; Ca; Cyclomethyltryptophan; PO47SIM-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
4.35Single7SIMCa7SIM-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
4.35Single7SIMCa; Ca; Cyclomethyltryptophan; PO47SIM-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
4.35Single7T9NM22 Fab7T9N-TSH-M22 Fab-PubChem 644078-Gs/β1/γ2
4.35Single7WI6LY3414957WI6-mGlu3; mGlu3-LY341495
4.35Single7WI6LY3414957WI6-mGlu3; mGlu3-LY341495
4.35Single7WI8LY3414957WI8-mGlu3; mGlu3-LY341495
4.35Single7WI8LY3414957WI8-mGlu3; mGlu3-LY341495
4.35Single7WIHLY27941937WIH-mGlu3; mGlu3-LY2794193
4.35Single7WIHLY27941937WIH-mGlu3; mGlu3-LY2794193
4.35Single7XW6M22 Fab7XW6-TSH-M22 Fab-ML109-Gs/β1/γ2
4.35Single7XW7K1-707XW7-TSH-K1-70
4.35Single8JCULY3414958JCU-mGlu2; mGlu3-LY341495
4.35Single8JCULY3414958JCU-mGlu2; mGlu3-LY341495
4.35Single8JCVLY3414958JCV-mGlu2; mGlu3-LY341495
4.35Single8JCVLY3414958JCV-mGlu2; mGlu3-LY341495
4.35Single8JCWLY3414958JCW-mGlu2; mGlu3-LY341495
4.35Single8JCWLY3414958JCW-mGlu2; mGlu3-LY341495
4.35Single8JCXLY3414958JCX-mGlu2; mGlu3-LY341495
4.35Single8JCXLY3414958JCX-mGlu2; mGlu3-LY341495
4.35Single8JCYLY3414958JCY-mGlu2; mGlu3-LY341495
4.35Single8JCYLY3414958JCY-mGlu2; mGlu3-LY341495
4.35Single8JCZLY3414958JCZ-mGlu2; mGlu3-LY341495
4.35Single8JCZLY3414958JCZ-mGlu2; mGlu3-LY341495
4.35Single8JD0Glutamate8JD0-mGlu2; mGlu3-Glutamate-NAM563
4.35Single8JD1Glutamate8JD1-mGlu2; mGlu3-Glutamate
4.35Single8JD1Glutamate8JD1-mGlu2; mGlu3-Glutamate
4.35Single8JD2Glutamate8JD2-mGlu2; mGlu3-Glutamate
4.35Single8JD2Glutamate8JD2-mGlu2; mGlu3-Glutamate
4.35Single8JD3Glutamate8JD3-mGlu2; mGlu3-Glutamate-HZR; PEF-Gi1/β1/γ2
4.35Single8JD3Glutamate8JD3-mGlu2; mGlu3-Glutamate-HZR; PEF-Gi1/β1/γ2
4.35Single8JD4Glutamate8JD4-mGlu2; mGlu4-Glutamate
4.35Single8JD4Glutamate8JD4-mGlu2; mGlu4-Glutamate
4.35Single8JD5Glutamate8JD5-mGlu2; mGlu4-Glutamate-BQI; HZE; PEF-Gi1/β1/γ2
4.35Single8JD5Glutamate8JD5-mGlu2; mGlu4-Glutamate-BQI; HZE; PEF-Gi1/β1/γ2
4.35Single8JD6Phosphoserine8JD6-mGlu4; mGlu4-Phosphoserine-N-(3-chlorophenyl)pyridine-2-carboxamide-Gi3/β1/γ2
4.35Single8JD6Phosphoserine8JD6-mGlu4; mGlu4-Phosphoserine-N-(3-chlorophenyl)pyridine-2-carboxamide-Gi3/β1/γ2
4.35Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
4.35Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
4.35Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
4.35Single8SZGCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-chim(NtGi1-Gq)/β1/γ2
4.35Single8SZGCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-chim(NtGi1-Gq)/β1/γ2
4.35Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/β1/γ2
4.35Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/β1/γ2
4.35Single8SZICa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZI-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi3/β1/γ2
4.35Single8SZICa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZI-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi3/β1/γ2
4.35Single8T7HQuisqualate8T7H-mGlu5; mGlu5-Quisqualate
4.35Single8T7HQuisqualate8T7H-mGlu5; mGlu5-Quisqualate
4.35Single8T8MQuisqualate8T8M-mGlu5; mGlu5-Quisqualate
4.35Single8T8MQuisqualate8T8M-mGlu5; mGlu5-Quisqualate
4.35Single8TAOQuisqualate8TAO-mGlu5; mGlu5-Quisqualate-CDPPB
4.35Single8TAOQuisqualate8TAO-mGlu5; mGlu5-Quisqualate-CDPPB
4.35Single8TQBCa; PAM VU60233268TQB-mGlu3; mGlu3-Ca; PAM VU6023326-Ca
4.35Single8TQBCa; PAM VU60233268TQB-mGlu3; mGlu3-Ca; PAM VU6023326-Ca
4.35Single8TR0LY3414958TR0-mGlu3; mGlu3-LY341495
4.35Single8TR0LY3414958TR0-mGlu3; mGlu3-LY341495
4.35Single8TR2Ca; LY3792688TR2-mGlu3; mGlu3-Ca; LY379268-Ca
4.35Single8TR2Ca; LY3792688TR2-mGlu3; mGlu3-Ca; LY379268-Ca
4.35Single8TRCLY3414958TRC-mGlu3; mGlu3-LY341495
4.35Single8TRCLY3414958TRC-mGlu3; mGlu3-LY341495
4.35Single8TRDLY3414958TRD-mGlu3; mGlu3-LY341495
4.35Single8TRDLY3414958TRD-mGlu3; mGlu3-LY341495
4.35Single8WG9(2S)-2-amino-4-phosphonobutanoic acid8WG9-mGlu4; mGlu2-(2S)-2-amino-4-phosphonobutanoic acid
4.35Single8WGBGlutammate8WGB-mGlu4; mGlu2-Glutammate-W9R-Gi3/β1/γ2
4.35Single8WGBGlutammate8WGB-mGlu4; mGlu2-Glutammate-W9R-Gi3/β1/γ2
4.35Single8WGCLY3792688WGC-mGlu4; mGlu2-LY379268
4.35Single8WGDWAG/WA68WGD-mGlu4; mGlu2-WAG/WA6
4.35Single8WGDWAG/WA68WGD-mGlu4; mGlu2-WAG/WA6
4.35Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
4.35Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
4.35Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/β1/γ2
4.35Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/β1/γ2
4.35Single8WVXNorrin8WVX-LGR4-Norrin
4.35Single8WVYNorrin8WVY-LGR4-Norrin
4.35Single8X0BQuisqualate8X0B-mGlu5; mGlu5-Quisqualate-VU0424465
4.35Single8X0BQuisqualate8X0B-mGlu5; mGlu5-Quisqualate-VU0424465
4.35Single8X0CQuisqualate8X0C-mGlu5; mGlu5-Quisqualate-VU0424465
4.35Single8X0CQuisqualate8X0C-mGlu5; mGlu5-Quisqualate-VU0424465
4.35Single8X0DQuisqualate8X0D-mGlu5; mGlu5-Quisqualate-VU0424465
4.35Single8X0DQuisqualate8X0D-mGlu5; mGlu5-Quisqualate-VU0424465
4.35Single8X0EQuisqualate8X0E-mGlu5; mGlu5-Quisqualate
4.35Single8X0EQuisqualate8X0E-mGlu5; mGlu5-Quisqualate
4.35Single8X0FQuisqualate8X0F-mGlu5; mGlu5-Quisqualate-VU0424465
4.35Single8X0FQuisqualate8X0F-mGlu5; mGlu5-Quisqualate-VU0424465
4.35Single8X0GQuisqualate8X0G-mGlu5; mGlu5-Quisqualate
4.35Single8X0GQuisqualate8X0G-mGlu5; mGlu5-Quisqualate
4.35Single8X0HQuisqualate8X0H-mGlu5; mGlu5-Quisqualate
4.35Single8X0HQuisqualate8X0H-mGlu5; mGlu5-Quisqualate
4.35Single8XUMR-spondin-28XUM-LGR4-R-spondin-2
4.35Single9ASBCa9ASB-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
4.35Single9ASBCa; Ca; Cyclomethyltryptophan; 9IG; PO49ASB-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
4.35Single9AVGCa9AVG-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs)/β1/γ2
4.35Single9AVGCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVG-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs)/β1/γ2
4.35Single9AVLCa9AVL-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi3/β2/γ2
4.35Single9AVLCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVL-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi3/β2/γ2
4.35Single9AVLCa9AVL-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi3/β2/γ2
4.35Single9AVLCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVL-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi3/β2/γ2
4.35Single9AXFCa9AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
4.35Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
4.35Single9AXFCa9AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
4.35Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
4.35Single9AYFCa9AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/β1/γ2
4.35Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/β1/γ2
4.35Single9C1PCa9C1P-CaS-Ca-Ca; Tryptophan; '6218; PO4
4.35Single9C1PCa; Tryptophan; '6218; PO49C1P-CaS-Ca-Ca; Tryptophan; '6218; PO4
4.35Single9C1PCa9C1P-CaS-Ca-Ca; Tryptophan; '6218; PO4
4.35Single9C1PCa; Tryptophan; '6218; PO49C1P-CaS-Ca-Ca; Tryptophan; '6218; PO4
4.35Single9C2FCa9C2F-CaS-Ca-Ca; Ca; Tryptophan; '6218; PO4
4.35Single9C2FCa; Ca; Tryptophan; '6218; PO49C2F-CaS-Ca-Ca; Ca; Tryptophan; '6218; PO4
4.35Single9C2FCa9C2F-CaS-Ca-Ca; Ca; Tryptophan; '6218; PO4
4.35Single9C2FCa; Ca; Tryptophan; '6218; PO49C2F-CaS-Ca-Ca; Ca; Tryptophan; '6218; PO4
4.35Single9II2Glutamate9II2-mGlu3; mGlu3-Glutamate-Arrestin2
4.35Single9II2Glutamate9II2-mGlu3; mGlu3-Glutamate-Arrestin2
4.35Single9II3Glutamate9II3-mGlu3; mGlu3-Glutamate-Arrestin2
4.35Single9II3Glutamate9II3-mGlu3; mGlu3-Glutamate-Arrestin2
4.17Single7DD6Ca7DD6-CaS-Ca-Ca; Ca; Tryptophan
4.17Single7DD6Ca; Ca; Tryptophan7DD6-CaS-Ca-Ca; Ca; Tryptophan
4.17Single7DD6Ca7DD6-CaS-Ca-Ca; Ca; Tryptophan
4.17Single7DD6Ca; Ca; Tryptophan7DD6-CaS-Ca-Ca; Ca; Tryptophan
4.17Single7DD7Ca7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
4.17Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
4.17Single7DD7Ca7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
4.17Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
4.17Single9ASBCa9ASB-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
4.17Single9ASBCa; Ca; Cyclomethyltryptophan; 9IG; PO49ASB-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
4.17Single9AVGCa9AVG-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs)/β1/γ2
4.17Single9AVGCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVG-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs)/β1/γ2
4.17Single9AYFCa9AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/β1/γ2
4.17Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/β1/γ2
4.00Single7KNUCalcitonin gene-related peptide-17KNU-CT Like-Calcitonin gene-related peptide-1-RAMP1
4.00Single7T9MCS-17 Antibody7T9M-TSH-CS-17 Antibody
4.00Single8TLMAnti-murine CCR8 antibody8TLM-CCR8-Anti-murine CCR8 antibody
4.00Single8Y63C20:0 Ceramide8Y63-FPR2-ALX-C20:0 Ceramide-Gi1/β1/γ2
3.85Single6O3CCholesterol6O3C-SMO-SAG21k-Cholesterol
3.85Single7FIGhCG7FIG-LH-hCG-chim(NtGi1L-Gs)/β1/γ2
3.85Single7UTZTR14027UTZ-TSH-TR1402-PubChem 644078-Gs/β1/γ2
3.85Single7XW5TSH7XW5-TSH-TSH-ML109-Gs/β1/γ2
3.85Single7ZI0Cholesterol7ZI0-SMO-SAG-Cholesterol
3.85Single8XOFLys058XOF-GPR30-Lys05-chim(NtGi1-Gs-CtGq)/β1/γ2
3.70Single5L7DCholesterol5L7D-SMO-Cholesterol
3.70Single7T9ITSH7T9I-TSH-TSH-Gs/β1/γ2
3.70Single7WC4Serotonin7WC4-5-HT2A-Serotonin
3.70Single7XKDBeta-Hydroxyandrosterone7XKD-ADGRG2-β-Hydroxyandrosterone-Gs/β1/γ2
3.70Single8I2GGlycoprotein hormones alpha chain8I2G-FSH-Glycoprotein hormones α chain-Compound 716340-Gs/β1/γ2
3.70Single9GE2Cholesterol9GE2-GPR55-ML184-Cholesterol-chim(CtGi1-G13)/β1/γ2
3.57Single7VDMSubstance-P7VDM-MRGPRX2-Substance-P-Gi1/β1/γ2
3.45Single7V6A-7V6A-M4-PubChem 9864275-Gi1/β1/γ2
3.45Single7WC5Psilocin7WC5-5-HT2A-Psilocin
3.45Single8X9UMetenolone8X9U-ADGRD1-Metenolone-chim(NtGi1-Gs)/β1/γ2
3.45Single8ZPLCholesterol8ZPL-CXCR4-HF51116-Cholesterol
3.45Single8ZPMCholesterol8ZPM-CXCR4-AMD070-Cholesterol
3.33Single6TP4ACT-4622066TP4-OX1-ACT-462206
3.33Single7S8NR-Zinc-35737S8N-MRGPRX2-R-Zinc-3573-chim(NtGi2L-Gs-CtGq)/β1/γ2
3.33Single7S8OR-Zinc-35737S8O-MRGPRX2-R-Zinc-3573-Gi1/β1/γ2
3.33Single7UL2SR486927UL2-NTS1-SR48692-Na
3.33Single8HNNSCH5467388HNN-CXCR3-SCH546738
3.33Single8YRGFospropofol8YRG-MRGPRX4-Fospropofol-chim(NtGi1-Gs-CtGq)/β1/γ2
3.33Consensusneurotensin_offOrthosteric Ligandnts1_off
3.33Consensusnts1_offOrthosteric Ligand7UL2-NTS1-SR48692-Na
3.23Single6C1QNDT95137276C1Q-C5a1-PMX53-NDT9513727
3.23Single6ZA8RTI-3a6ZA8-NTS1-RTI-3a
3.12Single8HQN9-S-HODE8HQN-GPR132-9-S-HODE-Gi1/β1/γ2
3.12Single8JD6N-(3-chlorophenyl)pyridine-2-carboxamide8JD6-mGlu4; mGlu4-Phosphoserine-N-(3-chlorophenyl)pyridine-2-carboxamide-Gi3/β1/γ2
3.12Single8K4NVF08K4N-GPR34-VF0-Gi1/β1/γ2
3.12Single8K4SDCA-3P8K4S-MRGPRX4-DCA-3P-chim(NtGi1L-Gs-CtGq)/β1/γ2
3.03Single8EJKTAK-8758EJK-FFA1-TAK-875-chim(NtGi1L-Gs-CtGq)/β1/γ2
2.94Single4PHUFasiglifam4PHU-FFA1-Fasiglifam
2.94Single6Z4QSR142948A6Z4Q-NTS1-SR142948A
2.94Single8EJCTAK-8758EJC-FFA1-TAK-875-chim(NtGi1L-Gs-CtGq)/β1/γ2
2.94Consensuscyslt_offOrthosteric Ligandcyslt2_off cyslt1_off
2.86Single5TZRMK86665TZR-FFA1-MK8666
2.86Single6RZ5Zafirlukast6RZ5-CysLT1-Zafirlukast-Na
2.86Single8JD5BQI; HZE; PEF8JD5-mGlu2; mGlu4-Glutamate-BQI; HZE; PEF-Gi1/β1/γ2
2.86Single8JGFBAM8-228JGF-MRGPRX1-BAM8-22-chim(NtGi1-Gs-CtGq)/β1/γ2
2.86Single8XBIS3E-LysoPS8XBI-GPR34-S3E-LysoPS
2.86Single9ITELPA9ITE-LPA6-LPA-chim(NtGi2-G13)/β1/γ2
2.86Consensusffa_onOrthosteric Ligandffa2_on ffa3_on
2.86Consensusffa_on_gpOrthosteric Ligandffa2_on_gp ffa3_on_gp
2.86Consensusgi_ffaOrthosteric Ligand8J21-FFA3-Butyric acid-Gi1/β1/γ2 8J22-FFA2-TUG-1375-Gi1/β1/γ2
2.78Single3VW7Vorapaxar; Na3VW7-PAR1-Vorapaxar; Na
2.78Single4PXZ2MeSADP4PXZ-P2Y12-2MeSADP
2.78Single4PY02MeSATP4PY0-P2Y12-2MeSATP
2.78Single5TZYMK8666; PubChem 1270535975TZY-FFA1-MK8666; PubChem 127053597
2.78Single7SHEPI; PE7SHE-GPR158-PI; PE
2.70Single7SHFPI; PE7SHF-GPR158-PI; PE-B5; RGS7
2.70Single8XBES3E-LysoPS8XBE-GPR34-S3E-LysoPS-Gi1/β1/γ1
2.56Single6RZ8ONO-20803656RZ8-CysLT2-ONO-2080365
2.56Single8XFTR-spondin-28XFT-LGR4-R-spondin-2-ZNRF3
2.56Single8Y69R-spondin-28Y69-LGR4-R-spondin-2-Cholesterol-ZNRF3
2.44Single8WVUR-spondin-18WVU-LGR4-R-spondin-1-RNF43
2.44Single8Y69R-spondin-28Y69-LGR4-R-spondin-2-Cholesterol-ZNRF3
2.38Single8XFPR-spondin-28XFP-LGR4-R-spondin-2-ZNRF3
2.22Single8XFSR-spondin-28XFS-LGR4-R-spondin-2-ZNRF3

PDB Summary
PDB 7TYF
Class B1
SubFamily Peptide
Type Calcitonin
SubType CT (AMY1)
Species Homo Sapiens
Ligand Amylin
Other Ligand(s) -
Protein Partners Gs/Beta1/Gamma2; RAMP1
PDB Resolution 2.2
Date 2022-03-23
D.O.I. 10.1126/science.abm9609
Net Summary
Imin 2.98
Number of Linked Nodes 1088
Number of Links 1418
Number of Hubs 255
Number of Links mediated by Hubs 919
Number of Communities 36
Number of Nodes involved in Communities 398
Number of Links involved in Communities 603
Path Summary
Number Of Nodes in MetaPath 141
Number Of Links MetaPath 140
Number of Shortest Paths 26527015
Length Of Smallest Path 3
Average Path Length 83.9582
Length of Longest Path 85
Minimum Path Strength 1.21
Average Path Strength 8.02868
Maximum Path Strength 25.48
Minimum Path Correlation 0.7
Average Path Correlation 1
Maximum Path Correlation 1
Minimum % Of Corr. Nodes 1.66667
Average % Of Corr. Nodes 53.4398
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 68.7521
Maximum Path Hubs % 100
AnnotationTypeLinks
Gene OntologyMolecular Function• binding   • guanyl nucleotide binding   • GTP binding   • nucleotide binding   • guanyl ribonucleotide binding   • purine ribonucleotide binding   • purine ribonucleoside triphosphate binding   • nucleoside phosphate binding   • ion binding   • purine nucleotide binding   • anion binding   • heterocyclic compound binding   • carbohydrate derivative binding   • ribonucleotide binding   • small molecule binding   • D1 dopamine receptor binding   • protein binding   • signaling receptor binding   • G protein-coupled receptor binding   • dopamine receptor binding   • protein-containing complex binding   • G-protein beta/gamma-subunit complex binding   • pyrophosphatase activity   • GTPase activity   • G protein activity   • ribonucleoside triphosphate phosphatase activity   • molecular function regulator activity   • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides   • hydrolase activity   • hydrolase activity, acting on acid anhydrides   • catalytic activity   • enzyme regulator activity   • molecular function activator activity   • phosphorus-oxygen lyase activity   • cyclase regulator activity   • enzyme activator activity   • cyclase activator activity   • cyclase activity   • adenylate cyclase regulator activity   • lyase activity   • adenylate cyclase activator activity   • adenylate cyclase activity   • cation binding   • metal ion binding   • developmental process   • multicellular organismal process   • epithelium development   • ectodermal placode morphogenesis   • epidermis development   • molting cycle process   • hair cycle   • animal organ development   • hair follicle placode formation   • tissue development   • ectodermal placode formation   • anatomical structure morphogenesis   • skin development   • skin epidermis development   • hair follicle development
Gene OntologyBiological Process• developmental process   • multicellular organismal process   • epithelium development   • ectodermal placode morphogenesis   • epidermis development   • molting cycle process   • hair cycle   • animal organ development   • hair follicle placode formation   • tissue development   • ectodermal placode formation   • anatomical structure morphogenesis   • skin development   • skin epidermis development   • hair follicle development   • molting cycle   • anatomical structure development   • anatomical structure formation involved in morphogenesis   • ectodermal placode development   • hair cycle process   • system process   • sensory perception of chemical stimulus   • sensory perception   • nervous system process   • sensory perception of smell   • cellular response to stimulus   • cellular response to nitrogen compound   • response to stimulus   • response to endogenous stimulus   • response to peptide hormone   • cellular response to peptide hormone stimulus   • response to oxygen-containing compound   • response to nitrogen compound   • response to glucagon   • cellular response to oxygen-containing compound   • cellular response to glucagon stimulus   • cellular response to endogenous stimulus   • cellular response to chemical stimulus   • response to hormone   • response to chemical   • cellular process   • cellular response to hormone stimulus   • multicellular organism development   • skeletal system development   • bone development   • system development   • regulation of body fluid levels   • wound healing   • homotypic cell-cell adhesion   • cell activation   • hemostasis   • biological regulation   • platelet aggregation   • blood coagulation   • cell adhesion   • cell-cell adhesion   • response to stress   • coagulation   • regulation of biological quality   • response to wounding   • platelet activation   • response to fluid shear stress   • vascular endothelial cell response to laminar fluid shear stress   • response to laminar fluid shear stress   • cellular response to stress   • cellular response to laminar fluid shear stress   • vascular endothelial cell response to fluid shear stress   • cellular response to fluid shear stress   • cognition   • developmental growth   • growth   • response to ketone   • response to prostaglandin   • response to lipid   • response to alcohol   • cellular response to prostaglandin stimulus   • cellular response to prostaglandin E stimulus   • cellular response to alcohol   • cellular response to lipid   • response to prostaglandin E   • cellular response to ketone   • regulation of biological process   • regulation of cellular process   • signaling   • adenylate cyclase-activating G protein-coupled receptor signaling pathway   • cell communication   • adenylate cyclase-modulating G protein-coupled receptor signaling pathway   • G protein-coupled receptor signaling pathway   • signal transduction   • homeostatic process   • positive regulation of biological process   • adaptive thermogenesis   • positive regulation of metabolic process   • multicellular organismal-level homeostasis   • regulation of cold-induced thermogenesis   • cold-induced thermogenesis   • temperature homeostasis   • positive regulation of cold-induced thermogenesis   • positive regulation of multicellular organismal process   • metabolic process   • regulation of multicellular organismal process   • regulation of metabolic process   • positive regulation of cellular process   • protein localization   • regulation of localization   • establishment of protein localization   • nitrogen compound transport   • localization   • cellular macromolecule localization   • regulation of peptide hormone secretion   • regulation of hormone levels   • establishment of protein localization to extracellular region   • protein secretion   • establishment of localization   • regulation of protein secretion   • regulation of secretion   • cellular localization   • regulation of hormone secretion   • regulation of protein localization   • regulation of peptide secretion   • transport   • hormone secretion   • protein localization to extracellular region   • peptide secretion   • regulation of secretion by cell   • secretion by cell   • amide transport   • signal release   • regulation of signaling   • regulation of transport   • secretion   • regulation of peptide transport   • regulation of establishment of protein localization   • export from cell   • cell-cell signaling   • regulation of protein transport   • peptide transport   • protein transport   • regulation of cellular localization   • regulation of insulin secretion   • peptide hormone secretion   • macromolecule localization   • hormone transport   • regulation of cell communication   • insulin secretion   • adenylate cyclase-activating adrenergic receptor signaling pathway   • adrenergic receptor signaling pathway   • establishment of localization in cell   • intracellular transport   • regulation of defense response   • regulation of response to external stimulus   • negative regulation of inflammatory response   • negative regulation of biological process   • inflammatory response to antigenic stimulus   • regulation of response to stress   • regulation of immune system process   • negative regulation of inflammatory response to antigenic stimulus   • defense response   • immune response   • negative regulation of response to stimulus   • negative regulation of immune response   • regulation of inflammatory response to antigenic stimulus   • response to external stimulus   • regulation of inflammatory response   • regulation of response to stimulus   • negative regulation of immune system process   • immune system process   • negative regulation of response to external stimulus   • negative regulation of defense response   • regulation of immune response   • inflammatory response   • positive regulation of adenylate cyclase activity   • positive regulation of molecular function   • regulation of molecular function   • positive regulation of cyclase activity   • activation of adenylate cyclase activity   • regulation of adenylate cyclase activity   • regulation of catalytic activity   • positive regulation of catalytic activity   • positive regulation of lyase activity   • response to dopamine   • cellular response to dopamine   • response to monoamine   • response to catecholamine   • adenylate cyclase-activating dopamine receptor signaling pathway   • cellular response to catecholamine stimulus   • G protein-coupled dopamine receptor signaling pathway   • cellular response to monoamine stimulus   • renal system process   • chemical homeostasis   • multicellular organismal-level water homeostasis   • multicellular organismal-level chemical homeostasis   • renal water homeostasis   • cellular anatomical structure   • membrane   • protein-containing complex   • extrinsic component of plasma membrane   • catalytic complex   • plasma membrane protein complex   • cytoplasmic side of membrane   • plasma membrane   • membrane protein complex   • heterotrimeric G-protein complex   • side of membrane   • cell periphery   • cytoplasmic side of plasma membrane   • GTPase complex
Gene OntologyCellular Component• cellular anatomical structure   • membrane   • protein-containing complex   • extrinsic component of plasma membrane   • catalytic complex   • plasma membrane protein complex   • cytoplasmic side of membrane   • plasma membrane   • membrane protein complex   • heterotrimeric G-protein complex   • side of membrane   • cell periphery   • cytoplasmic side of plasma membrane   • GTPase complex   • extrinsic component of membrane   • extrinsic component of cytoplasmic side of plasma membrane   • extracellular exosome   • membrane-bounded organelle   • extracellular vesicle   • extracellular organelle   • extracellular region   • organelle   • extracellular space   • vesicle   • extracellular membrane-bounded organelle   • intracellular anatomical structure   • cytoplasm   • cytosol   • Golgi apparatus subcompartment   • Golgi apparatus   • organelle subcompartment   • trans-Golgi network membrane   • intracellular membrane-bounded organelle   • endomembrane system   • intracellular organelle   • trans-Golgi network   • organelle membrane   • protein binding   • binding   • enzyme binding   • GTPase binding   • protein-containing complex binding   • pyrophosphatase activity   • GTPase activity   • ribonucleoside triphosphate phosphatase activity   • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides   • hydrolase activity   • hydrolase activity, acting on acid anhydrides   • catalytic activity   • signaling receptor complex adaptor activity   • protein-macromolecule adaptor activity   • molecular adaptor activity   • signaling adaptor activity   • multicellular organismal process   • system process   • sensory perception of chemical stimulus   • sensory perception   • nervous system process   • sensory perception of taste   • developmental process   • sensory organ development   • eye development   • animal organ development   • retina development in camera-type eye   • visual system development   • multicellular organism development   • camera-type eye development   • anatomical structure development   • sensory system development   • system development   • cell population proliferation   • cellular process   • cellular response to stimulus   • regulation of biological process   • regulation of cellular process   • response to stimulus   • signaling   • biological regulation   • signal transduction   • cell communication   • response to ketone   • response to prostaglandin   • response to lipid   • response to endogenous stimulus   • response to alcohol   • cellular response to prostaglandin stimulus   • response to oxygen-containing compound   • cellular response to oxygen-containing compound   • cellular response to endogenous stimulus   • cellular response to prostaglandin E stimulus   • cellular response to chemical stimulus   • cellular response to alcohol   • response to hormone   • response to chemical   • cellular response to lipid   • response to prostaglandin E   • cellular response to ketone   • cellular response to hormone stimulus   • small GTPase-mediated signal transduction   • Ras protein signal transduction   • intracellular signal transduction   • intracellular signaling cassette   • phospholipase C-activating G protein-coupled receptor signaling pathway   • G protein-coupled receptor signaling pathway   • cellular response to nitrogen compound   • response to dopamine   • cellular response to dopamine   • response to monoamine   • response to catecholamine   • adenylate cyclase-activating dopamine receptor signaling pathway   • cellular response to catecholamine stimulus   • G protein-coupled dopamine receptor signaling pathway   • response to nitrogen compound   • adenylate cyclase-activating G protein-coupled receptor signaling pathway   • cellular response to monoamine stimulus   • adenylate cyclase-modulating G protein-coupled receptor signaling pathway   • synaptic signaling   • cellular response to acetylcholine   • cell-cell signaling   • acetylcholine receptor signaling pathway   • postsynaptic signal transduction   • G protein-coupled acetylcholine receptor signaling pathway   • response to acetylcholine   • non-motile cilium   • 9+0 non-motile cilium   • cilium   • neuron projection   • photoreceptor disc membrane   • photoreceptor outer segment   • plasma membrane bounded cell projection   • cell projection   • photoreceptor cell cilium   • vacuolar membrane   • lytic vacuole   • vacuole   • lytic vacuole membrane   • bounding membrane of organelle   • lysosomal membrane   • lysosome   • synapse   • cell junction   • calcitonin family binding   • calcitonin gene-related peptide binding   • amide binding   • peptide hormone binding   • hormone binding   • molecular transducer activity   • coreceptor activity   • signaling receptor activity   • calcitonin family receptor activity   • peptide receptor activity   • G protein-coupled receptor activity   • G protein-coupled peptide receptor activity   • transmembrane signaling receptor activity   • calcitonin gene-related peptide receptor activity   • amylin receptor activity   • protein localization   • cellular localization   • establishment of protein localization   • nitrogen compound transport   • transport   • intracellular transport   • establishment of localization   • localization   • protein transport   • establishment of localization in cell   • cellular macromolecule localization   • macromolecule localization   • intracellular protein transport   • regulation of signaling   • regulation of signal transduction   • regulation of response to stimulus   • regulation of cell communication   • regulation of G protein-coupled receptor signaling pathway   • import into cell   • receptor internalization   • receptor-mediated endocytosis   • endocytosis   • vesicle-mediated transport   • blood vessel morphogenesis   • tube development   • angiogenesis   • vasculature development   • circulatory system development   • anatomical structure morphogenesis   • tube morphogenesis   • anatomical structure formation involved in morphogenesis   • blood vessel development   • calcitonin family receptor signaling pathway   • calcitonin gene-related peptide receptor signaling pathway   • regulation of protein modification process   • positive regulation of glycoprotein metabolic process   • positive regulation of protein metabolic process   • positive regulation of biological process   • carbohydrate derivative metabolic process   • positive regulation of macromolecule biosynthetic process   • positive regulation of protein glycosylation   • regulation of primary metabolic process   • positive regulation of metabolic process   • positive regulation of protein modification process   • positive regulation of biosynthetic process   • positive regulation of macromolecule metabolic process   • protein metabolic process   • protein modification process   • positive regulation of cellular process   • regulation of glycoprotein biosynthetic process   • positive regulation of glycoprotein biosynthetic process   • carbohydrate derivative biosynthetic process   • regulation of biosynthetic process   • regulation of protein metabolic process   • glycoprotein biosynthetic process   • primary metabolic process   • regulation of macromolecule metabolic process   • glycoprotein metabolic process   • macromolecule biosynthetic process   • protein glycosylation   • regulation of glycoprotein metabolic process   • biosynthetic process   • glycosylation   • macromolecule modification   • macromolecule glycosylation   • regulation of protein glycosylation   • metabolic process   • regulation of macromolecule biosynthetic process   • macromolecule metabolic process   • regulation of metabolic process   • amylin receptor signaling pathway   • monoatomic ion transport   • monoatomic cation transport   • calcium ion transport   • metal ion transport   • protein localization to cell periphery   • protein localization to plasma membrane   • localization within membrane   • protein localization to membrane   • amylin receptor 1 signaling pathway   • receptor complex   • cell surface   • plasma membrane signaling receptor complex   • G protein-coupled receptor complex   • CGRP receptor complex   • calcitonin family receptor complex   • G-protein beta-subunit binding   • fibroblast proliferation   • signaling receptor binding   • molecular function activator activity   • molecular function regulator activity   • signaling receptor regulator activity   • receptor ligand activity   • signaling receptor activator activity   • hormone activity   • lipid binding   • identical protein binding   • positive regulation of cell communication   • positive regulation of signal transduction   • positive regulation of response to stimulus   • regulation of intracellular signal transduction   • regulation of calcium-mediated signaling   • positive regulation of calcium-mediated signaling   • positive regulation of intracellular signal transduction   • calcium-mediated signaling   • positive regulation of signaling   • behavior   • eating behavior   • feeding behavior   • myeloid leukocyte differentiation   • regulation of leukocyte differentiation   • cellular developmental process   • regulation of developmental process   • negative regulation of biological process   • cell development   • regulation of cell differentiation   • regulation of cell development   • regulation of osteoclast differentiation   • cell differentiation   • osteoclast differentiation   • negative regulation of cellular process   • regulation of immune system process   • regulation of multicellular organismal process   • negative regulation of cell differentiation   • negative regulation of hemopoiesis   • regulation of multicellular organismal development   • negative regulation of leukocyte differentiation   • hemopoiesis   • regulation of myeloid cell differentiation   • negative regulation of developmental process   • regulation of myeloid leukocyte differentiation   • negative regulation of myeloid cell differentiation   • negative regulation of osteoclast differentiation   • negative regulation of myeloid leukocyte differentiation   • negative regulation of cell development   • myeloid cell differentiation   • negative regulation of immune system process   • immune system process   • regulation of hemopoiesis   • negative regulation of multicellular organismal process   • leukocyte differentiation   • monosaccharide metabolic process   • carbohydrate metabolic process   • hexose metabolic process   • small molecule metabolic process   • glucose metabolic process   • negative regulation of tissue remodeling   • homeostatic process   • negative regulation of bone remodeling   • regulation of bone remodeling   • tissue homeostasis   • regulation of tissue remodeling   • regulation of bone resorption   • bone resorption   • negative regulation of bone resorption   • multicellular organismal-level homeostasis   • tissue remodeling   • bone remodeling   • anatomical structure homeostasis   • amylin receptor 2 signaling pathway   • sensory perception of pain   • positive regulation of cAMP/PKA signal transduction   • cAMP/PKA signal transduction   • regulation of cAMP/PKA signal transduction   • amylin receptor 3 signaling pathway   • intracellular vesicle   • cytoplasmic vesicle   • secretory granule   • secretory vesicle   • somatodendritic compartment   • cell body   • neuronal cell body   • amyloid-beta binding   • peptide binding   • calcitonin receptor activity   • calcitonin binding   • positive regulation of cytosolic calcium ion concentration   • regulation of biological quality   • catabolic process   • RNA metabolic process   • macromolecule catabolic process   • nucleobase-containing compound metabolic process   • post-transcriptional regulation of gene expression   • regulation of RNA metabolic process   • regulation of mRNA catabolic process   • regulation of nucleobase-containing compound metabolic process   • RNA catabolic process   • negative regulation of macromolecule metabolic process   • mRNA catabolic process   • negative regulation of metabolic process   • regulation of catabolic process   • gene expression   • mRNA metabolic process   • nucleic acid metabolic process   • nucleobase-containing compound catabolic process   • regulation of mRNA stability   • regulation of gene expression   • negative regulation of gene expression   • negative regulation of biosynthetic process   • negative regulation of macromolecule biosynthetic process   • regulation of RNA stability   • nucleic acid catabolic process   • regulation of mRNA metabolic process   • positive regulation of ERK1 and ERK2 cascade   • positive regulation of MAPK cascade   • regulation of MAPK cascade   • MAPK cascade   • ERK1 and ERK2 cascade   • regulation of ERK1 and ERK2 cascade   • positive regulation of gene expression   • regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction   • positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction   • phosphatidylinositol 3-kinase/protein kinase B signal transduction   • response to corticosteroid   • response to steroid hormone   • response to glucocorticoid   • response to amyloid-beta   • cell surface receptor signaling pathway   • ossification   • regulation of ossification   • negative regulation of ossification   • amylin receptor complex   • amylin receptor complex 3   • amylin receptor complex 2   • amylin receptor complex 1   • axon   • acrosomal vesicle
SCOP2Domain Identifier• RAMP1-like   • Transducin (heterotrimeric G protein), gamma chain   • G protein-coupled receptor-like
SCOP2Family Identifier• RAMP1-like   • Transducin (heterotrimeric G protein), gamma chain   • G protein-coupled receptor-like
Membrane Protein Annotations-• Orientations of Proteins in Membranes database (OPM)   • Protein Data Bank of Transmembrane Proteins (PDBTM)   • MemProtMD


Details about the values in these tables can be found in the corresponding documentation page .
CodeNH2
PDB ResiduesL:L:?38
Environment DetailsOpen EMBL-EBI Page
CodeNH2
NameAMINO GROUP
Synonyms
Identifier
FormulaH2 N
Molecular Weight16.023
SMILES
PubChem123329
Formal Charge0
Total Atoms3
Total Chiral Atoms0
Total Bonds2
Total Aromatic Bonds0

CodeNAG
PDB ResiduesH:H:?1 H:H:?2
Environment DetailsOpen EMBL-EBI Page
CodeNAG
NameN-Acetylglucosamine
SynonymsN-Acetyl-D-glucosamine
Identifier
FormulaC8 H15 N O6
Molecular Weight221.208
SMILES
PubChem24139
Formal Charge0
Total Atoms30
Total Chiral Atoms5
Total Bonds30
Total Aromatic Bonds0

PDBsumOpen PDBsum Page
ChainA
ProteinG Protein α Sub unit
UniProtP63092
Sequence
>7TYF_Chain_A
DQRNEEKAQ REANKKIEK QLQKDKQVY RATHRLLLL GAGESGKNT 
IVKQMTSGI FETKFQVDK VNFHMFDVG AQRDERRKW IQCFNDVTA 
IIFVVASNR LQAALKLFD SIWNNKWLR DTSVILFLN KQDLLAEKV 
LAGKSKIED YFPEFARYT TPEDATPEP GEDPRVTRA KYFIRDEFL 
RISTASGDG RHYCYPHFT CSVDTENIR RVFNDCRDI IQRMHLRQY 
ELL


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainB
ProteinG Protein β Sub unit
UniProtP62873
Sequence
>7TYF_Chain_B
SELDQLRQE AEQLKNQIR DARKACADA TLSQITNNI DPVGRIQMR 
TRRTLRGHL AKIYAMHWG TDSRLLVSA SQDGKLIIW DSYTTNKVH 
AIPLRSSWV MTCAYAPSG NYVACGGLD NICSIYNLK TREGNVRVS 
RELAGHTGY LSCCRFLDD NQIVTSSGD TTCALWDIE TGQQTTTFT 
GHTGDVMSL SLAPDTRLF VSGACDASA KLWDVREGM CRQTFTGHE 
SDINAICFF PNGNAFATG SDDATCRLF DLRADQELM TYSHDNIIC 
GITSVSFSK SGRLLLAGY DDFNCNVWD ALKADRAGV LAGHDNRVS 
CLGVTDDGM AVATGSWDS FLKIWN


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainE
ProteinRAMP1
UniProtO60894
Sequence
>7TYF_Chain_E
GALLRELCL TQFQVDMEA VGETLWCDW GRTIRSYRE LADCTWHMA 
EKLGCFWPN AEVDRFFLA VHGRYFRSC PISGRAVRD PPGSILYPF 
IVVPITVTL LVTALVVWQ SKRT


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainG
ProteinG Protein γ Sub unit
UniProtP59768
Sequence
>7TYF_Chain_G
SIAQARKLV EQLKMEANI DRIKVSKAA ADLMAYCEA HAKEDPLLT 
PVPASENPF R


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainR
ProteinReceptor
UniProtP30988
Sequence
>7TYF_Chain_R
VGRKKMMDA QYKCYDRMQ QLPAYQGEG PYCNRTWDG WLCWDDTPA 
GVLSYQFCP DYFPDFDPS EKVTKYCDE KGVWFKHPE NNRTWSNYT 
MCNAFTPEK LKNAYVLYY LAIVGHSLS IFTLVISLG IFVFFRSLG 
CQRVTLHKN MFLTYILNS MIIIIHLVE VVPNGELVR RDPVSCKIL 
HFFHQYMMA CNYFWMLCE GIYLHTLIV VAVFTEKQR LRWYYLLGW 
GFPLVPTTI HAITRAVYF NDNCWLSVE THLLYIIHG PVMAALVVN 
FFFLLNIVR VLVTKMRET HEAESHMYL KAVKATMIL VPLLGIQFV 
VFPWRPSNK MLGKIYDYV MHSLIHFQG FFVATIYCF CNNEVQTTV 
KRQWAQF


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  




This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
9AUCB1PeptideCalcitoninCT (AMY1)Homo sapiensCalcitonin gene-related peptide-1-Gs/β1/γ2; RAMP12.42024-04-2410.1021/acs.biochem.4c00114
9AUC (No Gprot) B1PeptideCalcitoninCT (AMY1)Homo sapiensCalcitonin gene-related peptide-1-2.42024-04-2410.1021/acs.biochem.4c00114
7TYWB1PeptideCalcitoninCT (AMY1)Homo sapiensCalcitonin-1-Gs/β1/γ2; RAMP132022-03-2310.1126/science.abm9609
7TYW (No Gprot) B1PeptideCalcitoninCT (AMY1)Homo sapiensCalcitonin-1-32022-03-2310.1126/science.abm9609
7TYF (No Gprot) B1PeptideCalcitoninCT (AMY1)Homo sapiensAmylin-2.22022-03-2310.1126/science.abm9609




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