Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

All columns can be sorted in ascending/descending alphabetical order, clicking on the corresponding column header.

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg. Int. Strength Num. Of Links Community ConSurf
1G.S1.02 6.5025436
2G.s1h1.04 6.9745129
3G.s1h1.05 4.6175439
4G.H1.01 6.0825439
5G.S2.01 3.66429
6G.S3.03 6.798508
7G.S3.04 8.725427
8G.S3.05 4.032538
9G.S3.06 7.7575427
10G.s3h2.03 4.864529
11G.H2.04 9.69429
12G.H2.06 6.268529
13G.H2.07 7.24667629
14G.H2.10 5.718528
15G.h2s4.01 8.642509
16G.S4.03 4.365437
17G.S4.05 4.635437
18G.S4.07 11.37254128
19G.s4h3.03 5.9354128
20G.s4h3.04 6.542508
21G.H3.01 9.22254129
22G.H3.06 6.135406
23G.H3.09 6.676676139
24G.H3.13 9.7085136
25G.H3.17 9.22667625
26G.S5.03 4.374539
27G.S5.04 6.2754139
28G.S5.05 5.7575439
29G.S5.07 5.506539
30G.HG.01 6.394106
31G.hgh4.01 6.7375406
32G.hgh4.02 4.3408
33G.hgh4.05 15.0575406
34G.hgh4.21 5.54754164
35G.H4.03 3.49754164
36G.H4.07 9.96254105
37G.H4.08 8.68254103
38G.H4.10 11.3025407
39G.H4.12 7.7065104
40G.H4.13 7.5254103
41G.H4.15 8.3854138
42G.H4.16 3.78754104
43G.h4s6.02 5.035407
44G.h4s6.20 8.08434
45G.S6.02 8.385638
46G.S6.05 9.6085105
47G.s6h5.01 5.598539
48G.s6h5.05 6.1475439
49G.H5.03 7.4325439
50G.H5.05 5.995435
51G.H5.06 7.536534
52G.H5.08 7.51538
53G.H5.13 7.745438
54G.H5.15 4.41667638
55G.H5.16 4.69436
56G.H5.17 10.738535
57G.H5.19 4.5438
58G.H5.26 4.4525408
59b.1x4 2.9325408
60b.1x15 5.2575407
61b.h2x1 3.9375445
62b.h2x5 3.592545
63b.lhb1x3 3.2875442
64b.lhb1x6 3.78543
65b.l1x3 10.272559
66b.b2x1 7.7875428
67b.b2x5 8.00167657
68b.b3x3 3.798598
69b.l3x1 10.2425429
70b.l3x2 5.96667659
71b.b4x3 3.6675497
72b.b4x5 4.925497
73b.b4x6 10.466559
74b.l4x1 4.7975455
75b.b5x2 6.3125407
76b.b5x3 5.65559
77b.b5x5 5.87495
78b.l5x1 4.342598
79b.l5x5 9629
80b.b6x1 7.015429
81b.b6x5 4.90667696
82b.l6x5 6.554144
83b.b7x1 5.175144
84b.b7x2 4.198598
85b.l7x5 3.255406
86b.b8x3 3.655406
87b.b8x4 5.434506
88b.b9x3 5.79406
89b.l9x3 7.795629
90b.l9x6 6.968528
91b.l9x7 3.6825427
92b.b10x5 6.1925409
93b.l10x1 3.934563
94b.b11x3 3.9175465
95b.b11x6 7.7425429
96b.l11x2 10.0675429
97b.b12x6 7.41286728
98b.b13x7 8.262567
99b.l13x3 8.135669
100b.l13x6 6.7575429
101b.l13x7 4.2525469
102b.b14x1 5.1375428
103b.b14x3 5.0475465
104b.b15x1 8.826569
105b.b15x2 5.9425486
106b.b15x3 4.955469
107b.l15x1 4.932527
108b.l15x2 7.34469
109b.b16x2 4.5425465
110b.b16x4 9.376566
111b.b16x5 4.83405
112b.b16x6 8.66667668
113b.l17x3 10.3383689
114b.l17x6 8.5025429
115b.b18x3 4.696588
116b.l18x1 6.3685116
117b.l18x2 5.674117
118b.b19x2 7.75586
119b.l19x2 5.985689
120b.b20x2 7.6275486
121b.b20x4 10.2083688
122b.b20x6 6.64667686
123b.b20x7 7.0475409
124b.l20x2 11.13254119
125b.b21x5 5.435444
126b.b21x7 7.17645
127b.b22x5 5.4645117
128b.l22x5 7.638549
129b.b23x1 3.776545
130b.b23x2 4.402506
131b.b23x6 7.922547
132b.l23x1 5.116526
133b.b24x3 4.366575
134b.b24x4 8.35446
135b.b24x6 7.4375448
136b.l24x2 6.1675446
137b.l24x3 7.302545
138b.l25x3 8.81579
139b.l25x6 10.906528
140b.l25x7 4.0025477
141b.b26x3 3.614576
142b.b26x5 2.7525477
143b.b27x1 3.585476
144b.b27x3 4.336578
145b.l27x1 8.38729
146b.l27x2 9.15479
147b.b28x4 7.17576
148b.b28x5 4.1125455
149b.b28x6 8.216579
150g.h1x11 2.82254179
151g.l1x4 6.516508
152g.h2x11 11.94116
153g.ctx3 7.228549
154g.ctx6 4.53143746
155g.ctx15 7.015459
156g.ctx16 4.86875858
1571x46 4.745408
1581x60 5.19754156
159I1x50 5.8745158
1602x40 4.935409
1612x42 6.7925418
1622x46 5.37519
1632x50 8.12519
1642x53 4.88418
1652x56 5.13417
1662x57 5.246518
1672x60 5.88333617
168E1x50 6.815618
169E1x52 8.43517
1703x24 6.372516
1713x28 5.68333617
1723x32 7.318518
1733x34 3.9254206
1743x37 5.075417
1753x43 6.215418
1763x50 10.2525419
1773x51 9.0525408
1783x54 4.9025409
179I2x51 6.304537
180I2x53 8.954536
1814x50 5.186519
182E2.H181 9.82406
183E2.R182 9.0225405
1845x39 6.40667608
1855x47 8.24333618
1865x50 3.4575409
1875x58 5.942509
1886x44 4.89333619
1896x48 7.01333618
1906x49 4.2625407
1916x51 10.0075417
1926x52 8.59667617
193E3.V336 3.165403
1947x34 4.4225414
1957x39 7.42416
1967x42 7.185818
1977x49 8.228519
1987x53 5.41833619
199Lig 7.318461310
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

All columns can be sorted in ascending/descending alphabetical order, clicking on the corresponding column header.

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.


Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
1b.l2x3 b.l2x5 35.853.57NoNo085
2b.b3x1 b.l2x3 35.36798.14NoNo058
3b.b3x1 b.b6x5 34.97695.86NoYes056
4b.b3x3 b.b6x5 12.69796.31YesYes986
5b.l2x5 b.l4x2 43.545120.58NoNo054
63x49 I2x53 45.35185.75NoYes096
72x39 3x49 72.55582.89NoNo089
82x39 2x40 72.75382.92NoYes089
92x40 I1x50 73.93874.12YesYes098
10I1x49 I1x50 74.61837.71NoYes1558
11I1x49 b.l25x4 76.44426.3NoNo055
12b.l25x4 b.l27x2 76.65015.32NoYes059
13b.l25x3 b.l27x2 10012.61YesYes799
14b.b24x3 b.b25x7 14.27037.94YesNo057
15b.b25x7 b.lhb1x11 36.84937.07NoNo074
16b.lhb1x11 b.lhb1x9 36.71432.92NoNo043
17b.b23x1 b.lhb1x9 36.78014.28YesNo053
18b.b23x1 b.l22x1 26.61563YesNo459
19b.l22x1 g.ctx3 26.34148.83NoYes499
20g.ctx3 g.ctx4 56.29994.83YesNo097
21b.l26x5 g.ctx4 53.3053.35NoNo057
22b.l26x5 g.ctx15 50.53693.35NoYes059
23b.l4x2 g.ctx15 41.632115.3NoYes549
24b.b27x3 b.l25x3 79.45435.48YesYes789
25b.b27x3 b.b28x6 14.65383.64YesYes789
26b.b25x7 b.b28x6 22.736819.36NoYes079
27b.b28x4 b.l25x3 14.54017.86YesYes769
28b.b28x4 b.b28x6 32.26373.48YesYes769
29b.b26x3 b.b27x3 58.96064.42YesYes768
30b.b23x3 b.b27x1 31.07454.47NoYes776
31b.b23x3 b.b24x5 31.15754.47NoNo075
32b.b23x1 b.b24x5 31.06924.47YesNo055
33b.b27x1 b.b28x6 23.59243.68YesYes769
34b.b23x1 g.ctx6 31.74424.15YesYes456
35g.ctx3 g.ctx6 28.84679.5YesYes496
36b.b2x1 b.l27x1 27.80432.89YesYes289
37G.H5.19 I2x53 42.22613.27YesYes386
38G.H5.15 G.H5.19 39.57996.63YesYes388
39G.H5.15 G.S1.02 28.92463.98YesYes386
40G.S1.02 G.S3.03 28.0245.66YesYes068
41G.S1.04 G.S3.03 26.18424.87NoYes078
42G.S1.04 G.S3.05 11.78194.24NoYes378
43G.S1.04 G.S4.03 14.06765.71NoYes377
44G.H1.01 G.S1.06 10.11565.64YesNo098
45G.S1.06 G.S3.05 10.46057.07NoYes088
46G.S5.07 G.s5hg.01 11.69745.6YesNo099
47G.H5.07 G.S4.03 11.68615.89NoYes397
48G.H5.07 G.S5.05 11.36895.02NoYes399
49G.S5.05 G.s6h5.01 10.04613.89YesYes399
50b.b6x5 b.b7x2 26.98235.05YesYes968
51b.b7x2 b.b8x4 21.45063.79YesYes086
52b.b9x3 b.l7x5 11.14614.1YesYes066
53b.b2x1 b.b6x1 25.05229.58YesYes289
54b.b6x1 b.l9x6 25.24788.38YesYes298
55G.H2.07 b.l9x6 15.73283.86YesYes298
56b.b15x4 b.l13x3 17.30613.18NoYes069
57b.b15x4 b.b16x3 17.49361.95NoNo066
58b.b16x3 b.b19x2 17.6812.77NoYes066
59b.b18x3 b.b19x2 23.18685.02YesYes886
60b.b14x2 b.b18x3 35.18284.64NoYes078
61b.b14x1 b.b14x2 35.2823.07YesNo087
62b.b14x1 b.l13x6 35.5464.16YesYes289
63b.l13x6 b.l9x6 27.597611.49YesYes298
64G.H2.04 G.H2.07 13.715513YesYes299
65G.H3.15 G.H3.18 22.037210.98NoNo089
66G.H3.15 G.H3.17 22.14513.39NoYes085
67G.H2.04 G.H3.08 14.375310.72YesNo098
68b.l25x6 b.l27x1 29.646921.99YesYes289
69G.H3.18 G.h3s5.03 20.49274.28NoNo097
70G.S4.02 G.h3s5.03 20.67135.89NoNo087
71G.S4.02 G.S5.02 20.40413.07NoNo086
72G.H3.08 G.S4.04 13.9465.97NoNo089
73G.H3.09 G.S5.02 12.8445.24YesNo1396
74G.H4.16 G.h4s6.02 10.03563YesYes047
75G.H3.06 G.H4.15 11.037310.96YesYes068
76G.H3.06 G.H4.14 17.93833.98YesNo065
77G.H4.10 G.H4.14 15.40989.33YesNo075
78G.H3.17 b.l23x1 12.62096.7YesYes256
795x68 G.H5.16 13.15786.4NoYes376
803x54 G.H5.23 20.40053.63YesNo094
81G.H5.22 G.H5.23 11.18916.76NoNo044
82G.H5.19 G.H5.22 11.41623.71YesNo084
833x50 G.H5.23 18.878824.69YesNo094
843x46 3x50 11.23675.01NoYes199
852x42 3x46 27.31963.77YesNo189
862x42 3x49 28.226811.94YesNo089
87b.b15x2 b.b18x3 11.18437.68YesYes868
88b.b17x5 b.b21x1 20.97756.53NoNo077
89b.1x15 g.h1x15 17.4553.25YesNo078
90b.1x11 g.h1x15 16.16711.58NoNo088
91b.1x11 g.h1x11 14.87854.15NoYes089
92b.1x8 g.h1x11 11.00581.58NoYes1759
93b.1x8 g.h1x8 10.36161.7NoNo057
94b.b17x5 b.b17x7 12.25485.86NoNo078
95b.b21x1 g.l1x4 10.976813.1NoYes078
96b.l22x5 b.l24x2 12.15639.72YesYes496
97b.h2x5 b.l24x2 10.30752.95YesYes456
98b.h2x1 b.h2x5 13.14252.95YesYes455
99b.b21x7 b.b23x2 10.26578.21YesYes056
100b.b1x5 b.b28x4 17.950512.01NoYes036
101b.b1x5 b.l1x1 17.62775.17NoNo037
102I1x48 b.l1x1 17.344710.66NoNo077
103b.b6x5 b.l6x4 15.99184.35YesNo065
104b.l6x3 b.l6x4 15.66543.71NoNo065
105b.b7x1 b.b8x3 17.62623.63YesYes046
106b.b8x3 b.b9x4 17.1074.28YesNo069
107b.b12x6 b.l9x3 11.14625.29YesYes289
108b.b11x6 b.l9x3 11.775413.95YesYes299
109b.l11x1 b.l9x6 12.63264.35NoYes298
110b.b22x1 b.l25x6 38.86685.17NoYes288
111b.b22x1 b.b22x2 54.43736.4NoNo088
112b.b28x2 b.l27x2 23.42518.36NoYes049
1132x50 7x46 17.165310.31YesNo099
1142x46 2x50 14.59335.43YesYes199
1153x42 4x50 10.05834.52NoYes089
1162x48 4x50 39.51163.68NoYes169
1171x54 2x48 39.73481.71NoNo076
1181x54 2x44 39.81641.71NoNo076
1191x57 2x44 39.89847.68NoNo076
1201x57 I1x51 39.98155.01NoNo078
121I1x48 I1x51 40.0935.33NoNo078
1222x53 7x46 10.4976.46YesNo089
1235x461 Lig 13.37383.9NoYes170
1243x37 5x461 13.36739.59YesNo177
1253x37 4x53 17.49793.2YesNo078
1263x38 4x53 22.71713.42NoNo088
1273x38 4x50 22.83757.78NoYes189
1283x46 7x53 15.87936.04NoYes199
1293x43 7x53 16.68744.69YesYes189
1303x43 6x44 17.59933.65YesYes189
131b.b11x6 b.l11x1 21.53243.71YesNo299
132b.b22x2 b.b26x3 54.41174.5NoYes086
133I1x48 b.b28x2 22.90178.55NoNo074
134b.b22x1 b.l23x1 15.59732.89NoYes286
135G.H3.17 b.l25x6 10.220712YesYes258
1363x50 7x53 12.18166.17YesYes199
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


2D representation of the interactions of this orthosteric/allosteric ligand.


Links and nodes colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Node1Node2LinkStrengthCommIsNode1Hub?IsNode2Hub?Node1ConsNode2ConsNode1ShellNode2Shell
2x532x573.041YesYes8822
2x537x424.91YesYes8821
2x563x284.91YesYes7722
2x563x327.31YesYes7821
2x567x424.91YesYes7821
2x577x395.821YesYes8622
2x577x426.981YesYes8821
2x602x6410.81YesNo7612
2x603x284.641YesYes7712
2x607x356.911YesNo7512
2x607x394.641YesYes7612
2x607x424.641YesYes7811
2x60Lig3.671YesYes7010
2x647x357.81NoNo6522
3x283x323.351YesYes7821
3x323x364.421YesNo8711
3x327x4210.051YesYes8811
3x32Lig11.471YesYes8010
3x334x576.190NoNo7812
3x335x394.840NoYes7812
3x33Lig9.280NoYes7010
3x36Lig4.881NoYes7010
3x374x564.561YesNo7622
3x375x4619.591YesNo7721
4x565x434.641NoNo6621
4x565x4613.11NoNo6721
E2x52Lig8.780NoYes4010
5x395x4312.720YesNo8621
5x43Lig6.830NoYes6010
5x446x525.280NoYes7721
5x446x555.960NoNo7721
5x461Lig3.91NoYes7010
5x475x489.281YesNo8522
5x476x484.011YesYes8822
5x476x5220.361YesYes8721
5x486x523.091NoYes5721
6x486x525.011YesYes8721
6x516x5210.721YesYes7711
6x516x5512.081YesNo7711
6x517x345.361YesYes7411
6x51Lig11.871YesYes7010
6x52Lig7.121YesYes7010
6x547x343.650NoYes5421
6x55Lig3.571NoYes7010
6x587x343.930NoYes4421
7x34Lig4.751YesYes4010
7x387x427.361NoYes6811
7x38Lig11.621NoYes6010
7x397x4211.251YesYes6821
7x42Lig7.41YesYes8010

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

ShowSimilarityNetwork TypeNameLigandDescription
100.00Single8IRVRotigotine8IRV-D5-Rotigotine-chim(NtGi1-Gs)/β1/γ2
92.31Single7XKAConstrained Epinephrine7XKA-β2-Constrained Epinephrine
92.31Single8GDZConstrained Epinephrine8GDZ-β2-Constrained Epinephrine-Gs/β1/γ2
92.31Single8GEBConstrained Epinephrine8GEB-β2-Constrained Epinephrine-Gs/β1/γ2
92.31Single8GEGConstrained Epinephrine8GEG-β2-Constrained Epinephrine-Gs/β1/γ2
92.31Single8GGBConstrained Epinephrine8GGB-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
92.31Single8UNNConstrained Epinephrine8UNN-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
92.31Single8UNPConstrained Epinephrine8UNP-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
85.71Consensusgi_dopamineOrthosteric Ligand7JVR-D2-Bromoergocryptine-Gi1/β1/γ2 7CMV-D3-PD128907-Gi1/β1/γ2 7CMU-D3-Pramipexole-Gi1/β1/γ2 8IRS-D2-Rotigotine-Gi1/β1/γ2 8IRT-D3-Rotigotine-Gi1/β1/γ2
84.62Single6PS1Timolol6PS1-β2-Timolol
84.62Single7BTSL-Epinephrine7BTS-β1-L-Epinephrine
84.62Single7BU6L-Norepinephrine7BU6-β1-L-Norepinephrine
84.62Single8GE3Constrained Epinephrine8GE3-β2-Constrained Epinephrine-Gs/β1/γ2
84.62Single8GE9Constrained Epinephrine8GE9-β2-Constrained Epinephrine-Gs/β1/γ2
84.62Single8GECConstrained Epinephrine8GEC-β2-Constrained Epinephrine-Gs/β1/γ2
84.62Single8GEEConstrained Epinephrine8GEE-β2-Constrained Epinephrine-Gs/β1/γ2
84.62Single8GEHConstrained Epinephrine8GEH-β2-Constrained Epinephrine-Gs/β1/γ2
84.62Single8GFVConstrained Epinephrine8GFV-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
84.62Single8GFWConstrained Epinephrine8GFW-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
84.62Single8GFXConstrained Epinephrine8GFX-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
84.62Single8GFZConstrained Epinephrine8GFZ-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
84.62Single8GG0Constrained Epinephrine8GG0-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
84.62Single8GG1Constrained Epinephrine8GG1-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
84.62Single8GG3Constrained Epinephrine8GG3-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
84.62Single8GG4Constrained Epinephrine8GG4-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
84.62Single8GG6Constrained Epinephrine8GG6-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
84.62Single8GG9Constrained Epinephrine8GG9-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
84.62Single8GGIConstrained Epinephrine8GGI-β2-Constrained Epinephrine
84.62Single8GGJConstrained Epinephrine8GGJ-β2-Constrained Epinephrine
84.62Single8GGKConstrained Epinephrine8GGK-β2-Constrained Epinephrine
84.62Single8GGNConstrained Epinephrine8GGN-β2-Constrained Epinephrine
84.62Single8GGOConstrained Epinephrine8GGO-β2-Constrained Epinephrine
84.62Single8GGUConstrained Epinephrine8GGU-β2-Constrained Epinephrine
84.62Single8UNQConstrained Epinephrine8UNQ-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
84.62Single8UNRConstrained Epinephrine8UNR-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
84.62Single8UNUConstrained Epinephrine8UNU-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
84.62Single8UNVConstrained Epinephrine8UNV-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
84.62Single8UNYConstrained Epinephrine8UNY-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
84.62Single8UNZConstrained Epinephrine8UNZ-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
84.62Single8UO2Constrained Epinephrine8UO2-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
84.62Consensusadrenergic_onOrthosteric Ligandalpha_on beta_on
84.62Consensusd5_onOrthosteric Ligand8IRV-D5-Rotigotine-chim(NtGi1-Gs)/β1/γ2
84.62Consensusdopamine_onOrthosteric Ligandd2_on d1_on d3_on d4_on d5_on
84.62Consensusdopamine_on_gpOrthosteric Ligandd2_on_gp d1_on_gp d3_on_gp d4_on_gp d5_on_gp
80.00Single8JJ8Formoterol8JJ8-β2-Formoterol
80.00Consensusd2_on_gpOrthosteric Ligand7JVR-D2-Bromoergocryptine-Gi1/β1/γ2 8IRS-D2-Rotigotine-Gi1/β1/γ2
78.57Single2RH1S-Carazolol2RH1-β2-S-Carazolol
78.57Single5C1MBU725C1M-μ-BU72
78.57Single6KUWPubChem 572132346KUW-α2c-PubChem 57213234
78.57Single6PS3S-Carvedilol6PS3-β2-S-Carvedilol
78.57Single7BVQS-Carazolol7BVQ-β1-S-Carazolol
78.57Single7S0FIsoprenaline7S0F-β1-Isoprenaline-Gi1/β1/γ2
78.57Single7XK9Constrained Isoproterenol7XK9-β2-Constrained Isoproterenol-Na
78.57Single8GFYConstrained Epinephrine8GFY-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
78.57Single8GG2Constrained Epinephrine8GG2-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
78.57Consensusadrenergic_offOrthosteric Ligandalpha_off beta_off
78.57Consensusadrenergic_on_gpOrthosteric Ligandalpha_on_gp beta_on_gp
78.57Consensusalpha2c_offOrthosteric Ligand6KUW-α2c-PubChem 57213234
78.57Consensusamine_offOrthosteric Ligand5ht_off adrenergic_off dopamine_off histamine_off muscarinic_off
78.57Consensusamine_offonOrthosteric Ligandamine_off amine_on
78.57Consensusamine_offon_gpOrthosteric Ligandamine_on_gp amine_off
78.57Consensusamine_onOrthosteric Ligand5ht_on adrenergic_on dopamine_on histamine_on muscarinic_on trace-amine_on
78.57Consensusbeta2_offOrthosteric Ligand2RH1-β2-S-Carazolol 6PS3-β2-S-Carvedilol 6PS5-β2-S-Propranolol 3D4S-β2-Timolol 3NY8-β2-ICI118-551 3NY9-β2-ICI118-551 6PRZ-β2-S-Alprenolol
78.57Consensusbeta_offOrthosteric Ligandbeta1_off beta2_off
78.57Consensusd2_onOrthosteric Ligand7JVR-D2-Bromoergocryptine-Gi1/β1/γ2 8IRS-D2-Rotigotine-Gi1/β1/γ2
78.57Consensusd4_onOrthosteric Ligand8IRU-D4-Rotigotine-chim(NtGi1-Gs-CtGi1)/β1/γ2
78.57Consensusgi_adrenergicOrthosteric Ligand7EJ0-α2a-L-Norepinephrine-Go/β1/γ2 7EJK-α2a-Oxymetazoline-Go/β1/γ2 7W7E-α2a-PubChem 164946676-Go/β1/γ2 7W6P-α2a-N-pyridin-4-ylisoquinolin-4-amine-Go/β1/γ2 7EJ8-α2a-Brimonidine-Go/β1/γ2 6K42-α2b-Dexmedetomidine-Gi1/β1/γ2 7EJA-α2a-Dexmedetomidine-Go/β1/γ2 7S0F-β1-Isoprenaline-Gi1/β1/γ2
78.57Consensusgs_amineOrthosteric Ligandgs_5ht gs_adrenergic gs_dopamine gs_histamine gs_trace-amine
76.92Single4LDOL-Epinephrine4LDO-β2-L-Epinephrine
76.92Single6PS0S-Carazolol6PS0-β2-S-Carazolol
76.92Single6PS4ICI118-5516PS4-β2-ICI118-551
76.92Single6PS5S-Propranolol6PS5-β2-S-Propranolol
76.92Single7CMUPramipexole7CMU-D3-Pramipexole-Gi1/β1/γ2
76.92Single7DHISalbutamol7DHI-β2-Salbutamol-Gs/β1/γ2
76.92Single7RANPubChem 1645758477RAN-5-HT2A-PubChem 164575847-chim(NtGi2L-Gs-CtGq)/β1/γ2
76.92Single8GE1Constrained Epinephrine8GE1-β2-Constrained Epinephrine-Gs/β1/γ2
76.92Single8GE4Constrained Epinephrine8GE4-β2-Constrained Epinephrine-Gs/β1/γ2
76.92Single8GE6Constrained Epinephrine8GE6-β2-Constrained Epinephrine-Gs/β1/γ2
76.92Single8GE7Constrained Epinephrine8GE7-β2-Constrained Epinephrine-Gs/β1/γ2
76.92Single8GE8Constrained Epinephrine8GE8-β2-Constrained Epinephrine-Gs/β1/γ2
76.92Single8GEAConstrained Epinephrine8GEA-β2-Constrained Epinephrine-Gs/β1/γ2
76.92Single8GEDConstrained Epinephrine8GED-β2-Constrained Epinephrine-Gs/β1/γ2
76.92Single8GEFConstrained Epinephrine8GEF-β2-Constrained Epinephrine-Gs/β1/γ2
76.92Single8GG5Constrained Epinephrine8GG5-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
76.92Single8GG7Constrained Epinephrine8GG7-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
76.92Single8GG8Constrained Epinephrine8GG8-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
76.92Single8GGLConstrained Epinephrine8GGL-β2-Constrained Epinephrine
76.92Single8GGMConstrained Epinephrine8GGM-β2-Constrained Epinephrine
76.92Single8GGPConstrained Epinephrine8GGP-β2-Constrained Epinephrine
76.92Single8GGQConstrained Epinephrine8GGQ-β2-Constrained Epinephrine
76.92Single8GGSConstrained Epinephrine8GGS-β2-Constrained Epinephrine
76.92Single8GGTConstrained Epinephrine8GGT-β2-Constrained Epinephrine
76.92Single8GGVConstrained Epinephrine8GGV-β2-Constrained Epinephrine
76.92Single8GGXConstrained Epinephrine8GGX-β2-Constrained Epinephrine
76.92Single8UNLConstrained Epinephrine8UNL-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
76.92Single8UNMConstrained Epinephrine8UNM-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
76.92Single8UNOConstrained Epinephrine8UNO-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
76.92Single8UNWConstrained Epinephrine8UNW-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
76.92Single8UO0Constrained Epinephrine8UO0-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
76.92Single8UO1Constrained Epinephrine8UO1-β2-Constrained Epinephrine-GTP; Mg-Gs/β1/γ2
76.92Consensus5ht_on_gpOrthosteric Ligand5ht1_on_gp 5ht2_on_gp 5ht4_on_gp 5ht5_on_gp 5ht6_on_gp 5ht7_on_gp
76.92Consensusd3_onOrthosteric Ligand7CMV-D3-PD128907-Gi1/β1/γ2 8IRT-D3-Rotigotine-Gi1/β1/γ2 7CMU-D3-Pramipexole-Gi1/β1/γ2
76.92Consensusd3_on_gpOrthosteric Ligand7CMV-D3-PD128907-Gi1/β1/γ2 8IRT-D3-Rotigotine-Gi1/β1/γ2 7CMU-D3-Pramipexole-Gi1/β1/γ2
73.33Single3P0GBI1671073P0G-β2-BI167107
73.33Single3SN6BI1671073SN6-β2-BI167107-Gs/β1/γ2
73.33Single4LDLHydroxybenzylisoproterenol4LDL-β2-Hydroxybenzylisoproterenol
73.33Single5D5AS-Carazolol5D5A-β2-S-Carazolol
73.33Single5D5BS-Carazolol5D5B-β2-S-Carazolol
73.33Single6H7JIsoprenaline6H7J-β1-Isoprenaline
73.33Single6N48BI1671076N48-β2-BI167107-PubChem 138454256
73.33Single7JJOIsoprenaline7JJO-β1-Isoprenaline-Gs/β1/γ2
73.33Single7JVPSKF839597JVP-D1-SKF83959-Gs/β1/γ2
73.33Single7W6PN-pyridin-4-ylisoquinolin-4-amine7W6P-α2a-N-pyridin-4-ylisoquinolin-4-amine-Go/β1/γ2
73.33Single7W7EPubChem 1649466767W7E-α2a-PubChem 164946676-Go/β1/γ2
73.33Single8E0GBU728E0G-μ-BU72
73.33Single8IRRRotigotine8IRR-D1-Rotigotine-Gs/β1/γ2
73.33Single8IRURotigotine8IRU-D4-Rotigotine-chim(NtGi1-Gs-CtGi1)/β1/γ2
73.33Consensusamine_on_gpOrthosteric Ligand5ht_on_gp adrenergic_on_gp dopamine_on_gp histamine_on_gp muscarinic_on_gp trace-amine_on_gp
73.33Consensusbeta1_offOrthosteric Ligand2VT4-β1-Cyanopindolol 2YCW-β1-S-Carazolol 2YCZ-β1-Iodocyanopindolol 5A8E-β1-7-Methylcyanopindolol-Na 3ZPQ-β1-4-(piperazin-1- yl)-1H-indole-Na 3ZPR-β1-4-methyl-2-(piperazin-1-yl)-Na
73.33Consensusbeta2_onOrthosteric Ligand7DHI-β2-Salbutamol-Gs/β1/γ2 6NI3-β2-BI167107-Gs/β1/γ2
73.33Consensusbeta2_on_gpOrthosteric Ligand7DHI-β2-Salbutamol-Gs/β1/γ2 6NI3-β2-BI167107-Gs/β1/γ2
73.33Consensusd1_on_gpOrthosteric Ligand7F0T-D1-Dopamine-Gs/β1/γ2 7CKY-D1-PW0464-Gs/β1/γ2 8IRR-D1-Rotigotine-Gs/β1/γ2 7JV5-D1-SKF81297-Gs/β1/γ2 7JVP-D1-SKF83959-Gs/β1/γ2 7X2D-D1-Tavapadon-Gs/β1/γ2 7CKX-D1-A77636-Gs/β1/γ2 7JVQ-D1-Apomorphine-Gs/β1/γ2 7CKW-D1-Fenoldopam-Gs/β1/γ2
73.33Consensusd4_on_gpOrthosteric Ligand8IRU-D4-Rotigotine-chim(NtGi1-Gs-CtGi1)/β1/γ2
73.33Consensusgi_5htOrthosteric Ligand8FYT-5-HT1A-LSD-Gi1/β1/γ1 7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/β1/γ2 8UGY-5-HT1E-Mianserin-Gi1/β1/γ1 8W8B-5-HT1A-SEP-363856-Gi1/β1/γ2 7E2Y-5-HT1A-Serotonin-Gi1/β1/γ2 7E32-5-HT1D-Serotonin-Gi1/β1/γ2 7XTA-5-HT4-Serotonin-Gi1/β1/γ2 8UH3-5-HT1E-Setiptiline-Gi1/β1/γ1 8JSP-5-HT1A-Ulotaront-Gi1/β1/γ2 8FYL-5-HT1A-Vilazodone-Gi1/β1/γ1 8JT6-5-HT1A-(R)-IHCH-7179-Gi1/β1/γ2 8FYE-5-HT1A-4-F,5-MeO-PyrT-Gi1/β1/γ1 7X5H-5-HT5A-5-CT-Gi1/β1/γ2 8FY8-5-HT1A-5-MeO-DMT-Gi1/β1/γ1 7E2Z-5-HT1A-Aripiprazole-Gi1/β1/γ2 7E33-5-HT1E-BRL-54443-Gi1/β1/γ2 8FYX-5-HT1A-Buspirone-Gi1/β1/γ1 7EXD-5-HT1F-Lasmiditan-Gi1/β1/γ2 7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/β1/γ2
73.33Consensusgs_dopamineOrthosteric Ligand7F0T-D1-Dopamine-Gs/β1/γ2 7CKW-D1-Fenoldopam-Gs/β1/γ2 7CKY-D1-PW0464-Gs/β1/γ2 8IRV-D5-Rotigotine-chim(NtGi1-Gs)/β1/γ2 8IRR-D1-Rotigotine-Gs/β1/γ2 7JV5-D1-SKF81297-Gs/β1/γ2 7JVP-D1-SKF83959-Gs/β1/γ2 7X2D-D1-Tavapadon-Gs/β1/γ2 7CKX-D1-A77636-Gs/β1/γ2 7JVQ-D1-Apomorphine-Gs/β1/γ2
71.43Single2VT4Cyanopindolol2VT4-β1-Cyanopindolol
71.43Single2YCYCyanopindolol2YCY-β1-Cyanopindolol
71.43Single3NY8ICI118-5513NY8-β2-ICI118-551
71.43Single3NYAS-Alprenolol3NYA-β2-S-Alprenolol
71.43Single3ZPQ4-(piperazin-1- yl)-1H-indole3ZPQ-β1-4-(piperazin-1- yl)-1H-indole-Na
71.43Single4GBRS-Carazolol4GBR-β2-S-Carazolol
71.43Single6H7MSalbutamol6H7M-β1-Salbutamol
71.43Single6PRZS-Alprenolol6PRZ-β2-S-Alprenolol
71.43Single6PS2S-Alprenolol6PS2-β2-S-Alprenolol
71.43Single7CRHSKF839597CRH-D1-SKF83959-Gs/β1/γ2
71.43Single7E32Serotonin7E32-5-HT1D-Serotonin-Gi1/β1/γ2
71.43Single7JVQApomorphine7JVQ-D1-Apomorphine-Gs/β1/γ2
71.43Single7LJCSKF-812977LJC-D1-SKF-81297-Mevidalen-Gs/β1/γ2
71.43Single7S0GIsoprenaline7S0G-β1-Isoprenaline-chim(Gi1-CtGs)/β1/γ2
71.43Single8IRTRotigotine8IRT-D3-Rotigotine-Gi1/β1/γ2
71.43Single8JJOAlprenolol8JJO-β2-Alprenolol
71.43Single9CBMDexmedetomidine9CBM-α2a-Dexmedetomidine-Gi1/β1/γ2
71.43Consensus5ht1d_on_gpOrthosteric Ligand7E32-5-HT1D-Serotonin-Gi1/β1/γ2
71.43Consensusalpha_onOrthosteric Ligandalpha1_on alpha2_on
71.43Consensusdopamine_offOrthosteric Ligandd2_off d3_off
70.59Single3NY9ICI118-5513NY9-β2-ICI118-551
69.23Single7DHRIsoprenaline7DHR-β2-Isoprenaline-Gs/β1/γ2
69.23Single7X5H5-CT7X5H-5-HT5A-5-CT-Gi1/β1/γ2
69.23Single7YMHNorepinephrine7YMH-Alpha1A-Norepinephrine-chim(Gs-CtGq)
69.23Single8GGAConstrained Epinephrine8GGA-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
69.23Single8GGCConstrained Epinephrine8GGC-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
69.23Single8GGRConstrained Epinephrine8GGR-β2-Constrained Epinephrine
69.23Single8GGWConstrained Epinephrine8GGW-β2-Constrained Epinephrine
69.23Single8GGZConstrained Epinephrine8GGZ-β2-Constrained Epinephrine
69.23Single8GH0Constrained Epinephrine8GH0-β2-Constrained Epinephrine
69.23Single8TZQL-Dopamine8TZQ-D2-L-Dopamine-Go/β1/γ2
69.23Single8UNSConstrained Epinephrine8UNS-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
69.23Single8UNTConstrained Epinephrine8UNT-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
69.23Single8UNXConstrained Epinephrine8UNX-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
69.23Consensus5ht1e_onOrthosteric Ligand7E33-5-HT1E-BRL-54443-Gi1/β1/γ2 8UGY-5-HT1E-Mianserin-Gi1/β1/γ1 8UH3-5-HT1E-Setiptiline-Gi1/β1/γ1
69.23Consensus5ht_onOrthosteric Ligand5ht1_on 5ht2_on 5ht4_on 5ht5_on 5ht6_on 5ht7_on
69.23Consensusalpha2_offOrthosteric Ligandalpha2c_off
69.23Consensusgs_5htOrthosteric Ligand7XTC-5-HT7-5-CT-Gs/β1/γ2 7XTB-5-HT6-Serotonin-Gs/β1/γ2 8JLZ-5-HT6-ST1936-Gs/β1/γ2 7XT8-5-HT4-Serotonin-Gs/β1/γ2
68.75Single3D4STimolol3D4S-β2-Timolol
68.75Single4AMIBucindolol4AMI-β1-Bucindolol
68.75Single4LDEBI1671074LDE-β2-BI167107
68.75Single6H7OCyanopindolol6H7O-β1-Cyanopindolol
68.75Single6MXTSalmeterol6MXT-β2-Salmeterol
68.75Single6VMSBromoergocryptine6VMS-D2-Bromoergocryptine-Gi1/β1/γ2
68.75Single7YITNalfurafine7YIT-κ-Nalfurafine
68.75Single7YMJTamsulosin7YMJ-Alpha1A-Tamsulosin
68.75Single8FYE4-F,5-MeO-PyrT8FYE-5-HT1A-4-F,5-MeO-PyrT-Gi1/β1/γ1
68.75Single8IRSRotigotine8IRS-D2-Rotigotine-Gi1/β1/γ2
68.75Single9MQLIsoquinuclidine9MQL-κ-Isoquinuclidine
68.75Consensusalpha1_offOrthosteric Ligandalpha1a_off
68.75Consensusalpha1a_offOrthosteric Ligand7YMJ-Alpha1A-Tamsulosin
68.75Consensusbeta_onOrthosteric Ligandbeta1_on beta2_on beta3_on
68.75Consensusbeta_on_gpOrthosteric Ligandbeta1_on_gp beta2_on_gp beta3_on_gp
66.67Single2Y03Isoprenaline2Y03-β1-Isoprenaline
66.67Single2YCWS-Carazolol2YCW-β1-S-Carazolol
66.67Single4IARErgotamine4IAR-5-HT1B-Ergotamine
66.67Single5D6LS-Carazolol5D6L-β2-S-Carazolol
66.67Single5JQHS-Carazolol5JQH-β2-S-Carazolol
66.67Single5WIUNemonapride5WIU-D4-Nemonapride
66.67Single5WIVNemonapride5WIV-D4-Nemonapride-Na
66.67Single5X7DS-Carazolol5X7D-β2-S-Carazolol-PubChem 129318963
66.67Single6E67BI1671076E67-β2-BI167107-Gs (fused)
66.67Single7C61Ergotamine7C61-5-HT1B-Ergotamine
66.67Single7CKXA776367CKX-D1-A77636-Gs/β1/γ2
66.67Single7WC6LSD7WC6-5-HT2A-LSD
66.67Single7X1TTaltirelin7X1T-TRH-Taltirelin-chim(NtGi2L-Gs-CtGq)/β1/γ2
66.67Single8DCRDobutamine8DCR-β1-Dobutamine-Gs/β1/γ2
66.67Single8DZQmomSalB8DZQ-κ-momSalB-Go/β1/γ2
66.67Single8DZRGR89,6968DZR-κ-GR89,696-chim(NtGi2-Gt3)/β1/γ2
66.67Single9MQKIsoquinuclidine9MQK-κ-Isoquinuclidine
66.67Consensus5ht1_onOrthosteric Ligand5ht1a_on 5ht1d_on 5ht1e_on 5ht1f_on
66.67Consensus5ht1_on_gpOrthosteric Ligand5ht1a_on_gp 5ht1d_on_gp 5ht1e_on_gp 5ht1f_on_gp
66.67Consensus5ht1e_on_gpOrthosteric Ligand7E33-5-HT1E-BRL-54443-Gi1/β1/γ2 8UGY-5-HT1E-Mianserin-Gi1/β1/γ1 8UH3-5-HT1E-Setiptiline-Gi1/β1/γ1
66.67Consensus5ht5_on_gpOrthosteric Ligand5ht5a_on_gp
66.67Consensus5ht5a_on_gpOrthosteric Ligand7X5H-5-HT5A-5-CT-Gi1/β1/γ2 7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/β1/γ2 7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/β1/γ2
66.67Consensusalpha_offOrthosteric Ligandalpha1_off alpha2_off
66.67Consensusalpha_on_gpOrthosteric Ligandalpha1_on_gp alpha2_on_gp
66.67Consensusd1_onOrthosteric Ligand7F0T-D1-Dopamine-Gs/β1/γ2 7CKY-D1-PW0464-Gs/β1/γ2 8IRR-D1-Rotigotine-Gs/β1/γ2 7JV5-D1-SKF81297-Gs/β1/γ2 7JVP-D1-SKF83959-Gs/β1/γ2 7X2D-D1-Tavapadon-Gs/β1/γ2 7CKX-D1-A77636-Gs/β1/γ2 7JVQ-D1-Apomorphine-Gs/β1/γ2 7CKW-D1-Fenoldopam-Gs/β1/γ2
66.67Consensusmop_offOrthosteric Ligand4DKL-μ-β-Funaltrexamine 8QOT-μ-Nanobody-E 7UL4-μ-Alvimopan
66.67Consensusta1_onOrthosteric Ligand8W87-TA1-METH-chim(NtGi1L-Gs)/β1/γ2 8W89-TA1-PEA-chim(NtGi1L-Gs)/β1/γ2 8JLP-TA1-Ralmitaront-Gs/β1/γ2 8W8A-TA1-RO5256390-chim(NtGi1L-Gs)/β1/γ2 8W88-TA1-SEP-363856-Gs/β1/γ2 8JLO-TA1-Ulotaront-Gs/β1/γ2 8JLR-TA1-A77636-chim(NtGi1-Gs)/β1/γ2 8JSO-TA1-AMPH-chim(NtGi1-Gs)/β1/γ2 8ZSP-TA1-LSD-chim(NtGi1L-Gs-CtGq)/β1/γ2
66.67Consensustrace-amine_onOrthosteric Ligandta1_on
64.71Single2YCZIodocyanopindolol2YCZ-β1-Iodocyanopindolol
64.71Single4BVNCyanopindolol4BVN-β1-Cyanopindolol-Na
64.71Single6H7LDobutamine6H7L-β1-Dobutamine
64.71Single6IBLArformoterol6IBL-β1-Arformoterol
64.71Single6TKOArformoterol6TKO-β1-Arformoterol-Arrestin2
64.71Single7JVRBromoergocryptine7JVR-D2-Bromoergocryptine-Gi1/β1/γ2
64.71Consensusbeta1_onOrthosteric Ligand8DCR-β1-Dobutamine-Gs/β1/γ2 7S0F-β1-Isoprenaline-Gi1/β1/γ2
64.71Consensusbeta1_on_gpOrthosteric Ligand8DCR-β1-Dobutamine-Gs/β1/γ2 7S0F-β1-Isoprenaline-Gi1/β1/γ2
64.71Consensusd2_offOrthosteric Ligand6CM4-D2-Risperidone 6LUQ-D2-Haloperidol 7DFP-D2-Spiperone
64.29Single6K41Dexmedetomidine6K41-α2b-Dexmedetomidine-Go/β1/γ2
64.29Single6TPGEMPA6TPG-OX2-EMPA
64.29Single7CKZDopamine7CKZ-D1-Dopamine-Mevidalen-Gs/β1/γ2
64.29Single7E33BRL-544437E33-5-HT1E-BRL-54443-Gi1/β1/γ2
64.29Single7EJ8Brimonidine7EJ8-α2a-Brimonidine-Go/β1/γ2
64.29Single7EJADexmedetomidine7EJA-α2a-Dexmedetomidine-Go/β1/γ2
64.29Single7F24Dopamine7F24-D1-Dopamine-GDP-Gs/β1/γ2
64.29Single8JLNT1AM8JLN-TA1-T1AM-Gs/β1/γ2
64.29Single8THKA616038THK-Alpha1A-A61603-chim(NtGi2L-Gs-CtGq)/β1/γ2
64.29Single8THLEpinephrine8THL-Alpha1A-Epinephrine-chim(NtGi2L-Gs-CtGq)/β1/γ2
64.29Single8U02L-Dopamine8U02-D2-L-Dopamine-Go/β1/γ2
64.29Single8YH2Adenosine8YH2-A3A-Adenosine-Gi1/β1/γ2
64.29Single9CBLEpinephrine9CBL-α2a-Epinephrine-Gi1/β1/γ2
64.29Consensusalpha1_onOrthosteric Ligandalpha1a_on
64.29Consensusalpha1_on_gpOrthosteric Ligandalpha1a_on_gp
64.29Consensusalpha1a_onOrthosteric Ligand7EJ0-α2a-L-Norepinephrine-Go/β1/γ2 7EJ8-α2a-Brimonidine-Go/β1/γ2 7EJA-α2a-Dexmedetomidine-Go/β1/γ2 7EJK-α2a-Oxymetazoline-Go/β1/γ2 7W6P-α2a-N-pyridin-4-ylisoquinolin-4-amine-Go/β1/γ2 7W7E-α2a-PubChem 164946676-Go/β1/γ2
64.29Consensusalpha1a_on_gpOrthosteric Ligand7EJ0-α2a-L-Norepinephrine-Go/β1/γ2 7EJ8-α2a-Brimonidine-Go/β1/γ2 7EJA-α2a-Dexmedetomidine-Go/β1/γ2 7EJK-α2a-Oxymetazoline-Go/β1/γ2 7W6P-α2a-N-pyridin-4-ylisoquinolin-4-amine-Go/β1/γ2 7W7E-α2a-PubChem 164946676-Go/β1/γ2
62.50Single2YDVNECA2YDV-A2A-NECA
62.50Single4UHRCGS216804UHR-A2A-CGS21680
62.50Single5A8E7-Methylcyanopindolol5A8E-β1-7-Methylcyanopindolol-Na
62.50Single5G53NECA5G53-A2A-NECA-Gs
62.50Single6GT3Imaradenant6GT3-A2A-Imaradenant-Na
62.50Single6NI3BI1671076NI3-β2-BI167107-Gs/β1/γ2
62.50Single6TQ7SB-3348676TQ7-OX1-SB-334867
62.50Single6WGTLSD6WGT-5-HT2A-LSD
62.50Single7JV5SKF812977JV5-D1-SKF81297-Gs/β1/γ2
62.50Single8DCSCyanopindolol8DCS-β1-Cyanopindolol-Gs/β1/γ2
62.50Single8DZPmomSalB8DZP-κ-momSalB-Gi1/β1/γ2
62.50Single8VVFJDTic8VVF-κ-JDTic-Gi1/β1/γ2
62.50Single9IJDCarazolol9IJD-β3-Carazolol-chim(NtGi1-Gs)/β1/γ2
62.50Consensusgs_adrenergicOrthosteric Ligand7DHI-β2-Salbutamol-Gs/β1/γ2 7XJI-β3-Solabegron-Gs/β1/γ2 7JJO-β1-Isoprenaline-Gs/β1/γ2 6NI3-β2-BI167107-Gs/β1/γ2 8DCR-β1-Dobutamine-Gs/β1/γ2 7XJH-β3-Isoproterenol-Gs/β1/γ2 7DH5-β3-Mirabegron-Gs/β1/γ2
62.50Consensusta1_on_gpOrthosteric Ligand8W87-TA1-METH-chim(NtGi1L-Gs)/β1/γ2 8W89-TA1-PEA-chim(NtGi1L-Gs)/β1/γ2 8JLP-TA1-Ralmitaront-Gs/β1/γ2 8W8A-TA1-RO5256390-chim(NtGi1L-Gs)/β1/γ2 8W88-TA1-SEP-363856-Gs/β1/γ2 8JLO-TA1-Ulotaront-Gs/β1/γ2 8JLR-TA1-A77636-chim(NtGi1-Gs)/β1/γ2 8JSO-TA1-AMPH-chim(NtGi1-Gs)/β1/γ2 8ZSP-TA1-LSD-chim(NtGi1L-Gs-CtGq)/β1/γ2
62.50Consensustrace-amine_on_gpOrthosteric Ligandta1_on_gp
61.54Single3PBLEticlopride3PBL-D3-Eticlopride
61.54Single7E2YSerotonin7E2Y-5-HT1A-Serotonin-Gi1/β1/γ2
61.54Single7XTBSerotonin7XTB-5-HT6-Serotonin-Gs/β1/γ2
61.54Single7YS6Serotonin7YS6-5-HT6-Serotonin-chim(NtGi1-Gs)/β1/γ2
61.54Single8EF6Morphine8EF6-μ-Morphine-Gi1/β1/γ2
61.54Single8GGYConstrained Epinephrine8GGY-β2-Constrained Epinephrine
61.54Single8UO3Constrained Epinephrine8UO3-β2-Constrained Epinephrine-GTP; Mg-Gs/β1/γ2
61.54Single8YN4Histamine8YN4-H2-Histamine-chim(NtGi1L-Gs-CtGq)/β1/γ2
61.54Single9IJEEpinephrine9IJE-β3-Epinephrine-chim(NtGi1-Gs)/β1/γ2
61.54Consensusd3_offOrthosteric Ligand3PBL-D3-Eticlopride
61.11Single4UG2CGS216804UG2-A2A-CGS21680
61.11Single8X5YAstemizole8X5Y-H1-Astemizole
60.00Single2Y02Carmoterol2Y02-β1-Carmoterol
60.00Single2Y04Salbutamol2Y04-β1-Salbutamol
60.00Single3ZPR4-methyl-2-(piperazin-1-yl)3ZPR-β1-4-methyl-2-(piperazin-1-yl)-Na
60.00Single4EA3PubChem 102965614EA3-NOP-PubChem 10296561
60.00Single4QKX35V4QKX-β2-35V
60.00Single6K42Dexmedetomidine6K42-α2b-Dexmedetomidine-Gi1/β1/γ2
60.00Single7BU7BI1671077BU7-β1-BI167107
60.00Single7T2GMitragynine Pseudoindoxyl7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2
60.00Single7UL4Alvimopan7UL4-μ-Alvimopan
60.00Single7UM55-CT7UM5-5-HT5A-5-CT-chim(NtGi1-Go)/β1/γ2
60.00Single7UM6Lisuride7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/β1/γ2
60.00Single7WC7Lisuride7WC7-5-HT2A-Lisuride
60.00Single7X2CFenoldopam7X2C-D1-Fenoldopam-Fenoldopam-Gs/β1/γ2
60.00Single7XJHIsoproterenol7XJH-β3-Isoproterenol-Gs/β1/γ2
60.00Single7XTC5-CT7XTC-5-HT7-5-CT-Gs/β1/γ2
60.00Single7YACPaltusotine7YAC-SST2-Paltusotine-Gi1/β1/γ2
60.00Single8FY85-MeO-DMT8FY8-5-HT1A-5-MeO-DMT-Gi1/β1/γ1
60.00Single8JLJT1AM8JLJ-TA1-T1AM-chim(NtGi1-Gs)/β1/γ2
60.00Single8JXRLSD8JXR-D1-LSD
60.00Single8PJKST1718PJK-5-HT1A-ST171-t7m-Gi1/β1/γ1
60.00Single8UGYMianserin8UGY-5-HT1E-Mianserin-Gi1/β1/γ1
60.00Single8W87METH8W87-TA1-METH-chim(NtGi1L-Gs)/β1/γ2
60.00Single8W8ARO52563908W8A-TA1-RO5256390-chim(NtGi1L-Gs)/β1/γ2
60.00Single8WC7ZH86678WC7-TA1-ZH8667-chim(NtGi1-Gs)/β1/γ2
60.00Single8X64Desloratadine8X64-H1-Desloratadine
60.00Single8XVKAmbrisentan8XVK-ETA-Ambrisentan
60.00Single8ZSSRO52633978ZSS-TA1-RO5263397-chim(NtGi1-Gs)/β1/γ2
60.00Single9CHXS-Carazolol9CHX-β2-S-Carazolol
60.00Consensus5ht5_onOrthosteric Ligand5ht5a_on
60.00Consensus5ht5a_onOrthosteric Ligand7X5H-5-HT5A-5-CT-Gi1/β1/γ2 7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/β1/γ2 7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/β1/γ2
60.00Consensus5ht7_onOrthosteric Ligand7XTC-5-HT7-5-CT-Gs/β1/γ2
60.00Consensus5ht7_on_gpOrthosteric Ligand7XTC-5-HT7-5-CT-Gs/β1/γ2
60.00Consensusadenosine_on_gpOrthosteric Liganda1_on_gp a2_on_gp a3_on_gp
60.00Consensusalpha2_onOrthosteric Ligandalpha2b_on
60.00Consensusalpha2_on_gpOrthosteric Ligandalpha2b_on_gp
60.00Consensusalpha2b_onOrthosteric Ligand6K42-α2b-Dexmedetomidine-Gi1/β1/γ2
60.00Consensusalpha2b_on_gpOrthosteric Ligand6K42-α2b-Dexmedetomidine-Gi1/β1/γ2
60.00Consensusgs_trace-amineOrthosteric Ligand8W88-TA1-SEP-363856-Gs/β1/γ2 8JLJ-TA1-T1AM-chim(NtGi1-Gs)/β1/γ2 8JLO-TA1-Ulotaront-Gs/β1/γ2 8WC4-TA1-ZH8651-chim(NtGi1-Gs)/β1/γ2 8WC7-TA1-ZH8667-chim(NtGi1-Gs)/β1/γ2 8JLR-TA1-A77636-chim(NtGi1-Gs)/β1/γ2 8JSO-TA1-AMPH-chim(NtGi1-Gs)/β1/γ2 8W87-TA1-METH-chim(NtGi1L-Gs)/β1/γ2 8W89-TA1-PEA-chim(NtGi1L-Gs)/β1/γ2 8JLP-TA1-Ralmitaront-Gs/β1/γ2 8W8A-TA1-RO5256390-chim(NtGi1L-Gs)/β1/γ2
58.82Single2YCXCyanopindolol2YCX-β1-Cyanopindolol
58.82Single4RWADIPP-NH24RWA-δ-DIPP-NH2
58.82Single5F8UCyanopindolol5F8U-β1-Cyanopindolol
58.82Single6DRYMethylergonovine6DRY-5-HT2B-Methylergonovine
58.82Single6H7NS-Xamoterol6H7N-β1-S-Xamoterol
58.82Single7BZ2Arformoterol7BZ2-β2-Arformoterol-Gs/β1/γ2
58.82Single8FYTLSD8FYT-5-HT1A-LSD-Gi1/β1/γ1
58.82Single8JJLOlodaterol8JJL-β2-Olodaterol
58.82Consensus5ht1a_onOrthosteric Ligand8FYT-5-HT1A-LSD-Gi1/β1/γ1 7E2Y-5-HT1A-Serotonin-Gi1/β1/γ2 7E2Z-5-HT1A-Aripiprazole-Gi1/β1/γ2 8FYX-5-HT1A-Buspirone-Gi1/β1/γ1 8JSP-5-HT1A-Ulotaront-Gi1/β1/γ2 8JT6-5-HT1A-(R)-IHCH-7179-Gi1/β1/γ2 8FY8-5-HT1A-5-MeO-DMT-Gi1/β1/γ1 8FYE-5-HT1A-4-F,5-MeO-PyrT-Gi1/β1/γ1 8FYL-5-HT1A-Vilazodone-Gi1/β1/γ1
58.82Consensus5ht1a_on_gpOrthosteric Ligand8FYT-5-HT1A-LSD-Gi1/β1/γ1 8FYX-5-HT1A-Buspirone-Gi1/β1/γ1 8JSP-5-HT1A-Ulotaront-Gi1/β1/γ2 8JT6-5-HT1A-(R)-IHCH-7179-Gi1/β1/γ2 7E2Y-5-HT1A-Serotonin-Gi1/β1/γ2 7E2Z-5-HT1A-Aripiprazole-Gi1/β1/γ2 8FY8-5-HT1A-5-MeO-DMT-Gi1/β1/γ1 8FYE-5-HT1A-4-F,5-MeO-PyrT-Gi1/β1/γ1 8FYL-5-HT1A-Vilazodone-Gi1/β1/γ1
58.82Consensusbeta3_onOrthosteric Ligand7DH5-β3-Mirabegron-Gs/β1/γ2 7XJH-β3-Isoproterenol-Gs/β1/γ2 7XJI-β3-Solabegron-Gs/β1/γ2
58.82Consensusbeta3_on_gpOrthosteric Ligand7DH5-β3-Mirabegron-Gs/β1/γ2 7XJH-β3-Isoproterenol-Gs/β1/γ2 7XJI-β3-Solabegron-Gs/β1/γ2
58.82Consensuskop_onOrthosteric Ligand8F7W-κ-Dynorphin-Gi1/β1/γ2 8DZS-κ-GR89,696-chim(NtGi2-Gz)/β1/γ2 8DZP-κ-momSalB-Gi1/β1/γ2
58.82Consensusmop_onOrthosteric Ligand8F7R-μ-Endomorphin-Gi1/β1/γ2 8EF5-μ-Fentanyl-Gi1/β1/γ2 7SCG-μ-FH210-Gi1/β1/γ2 7T2H-μ-Lofentanil-Gi1/β1/γ2 7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2 8EF6-μ-Morphine-Gi1/β1/γ2 8EFB-μ-Oliceridine-Gi1/β1/γ2 7U2L-μ-PubChem 163201242-Gi1/β1/γ2 8EFO-μ-PZM21-Gi1/β1/γ2 8EFL-μ-SR17018-Gi1/β1/γ2 8F7Q-μ-β-Endorphin-Gi1/β1/γ2 7U2K-μ-C6-guano-Gi1/β1/γ2 8EFQ-μ-Damgo-Gi1/β1/γ2
58.82Consensusmop_on_gpOrthosteric Ligand8F7R-μ-Endomorphin-Gi1/β1/γ2 8EF5-μ-Fentanyl-Gi1/β1/γ2 7SCG-μ-FH210-Gi1/β1/γ2 7T2H-μ-Lofentanil-Gi1/β1/γ2 7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2 8EF6-μ-Morphine-Gi1/β1/γ2 8EFB-μ-Oliceridine-Gi1/β1/γ2 7U2L-μ-PubChem 163201242-Gi1/β1/γ2 8EFO-μ-PZM21-Gi1/β1/γ2 8EFL-μ-SR17018-Gi1/β1/γ2 8F7Q-μ-β-Endorphin-Gi1/β1/γ2 7U2K-μ-C6-guano-Gi1/β1/γ2 8EFQ-μ-Damgo-Gi1/β1/γ2
58.82Consensusnk1_offOrthosteric Ligand6HLP-NK1-Netupitant 6HLO-NK1-Aprepitant 6HLL-NK1-CP99994 6E59-NK1-L-760735
58.82Consensusopioid_offOrthosteric Ligandmop_off nop_off dop_off kop_off
57.89Single4AMJS-Carvedilol4AMJ-β1-S-Carvedilol
57.89Single4IB4Ergotamine4IB4-5-HT2B-Ergotamine
57.89Single8FYLVilazodone8FYL-5-HT1A-Vilazodone-Gi1/β1/γ1
57.89Single8PKMBefiradol8PKM-5-HT1A-Befiradol-t7m-Gi1/β1/γ1
57.89Single8WDTphotoNECA8WDT-A2A-photoNECA
57.89Single8ZSPLSD8ZSP-TA1-LSD-chim(NtGi1L-Gs-CtGq)/β1/γ2
57.89Consensusclass-a_on_gpOrthosteric Ligandsensory_on_gp alicarboxylic_on_gp amine_on_gp lipid_on_gp nucleotide_on_gp peptide_on_gp protein_on_gp
57.89Consensusgi_opioidOrthosteric Ligand8F7R-μ-Endomorphin-Gi1/β1/γ2 8EF5-μ-Fentanyl-Gi1/β1/γ2 7SCG-μ-FH210-Gi1/β1/γ2 7T2H-μ-Lofentanil-Gi1/β1/γ2 7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2 8DZP-κ-momSalB-Gi1/β1/γ2 8EF6-μ-Morphine-Gi1/β1/γ2 8F7X-NOP-Nociceptin-Gi1/β1/γ2 8EFB-μ-Oliceridine-Gi1/β1/γ2 7U2L-μ-PubChem 163201242-Gi1/β1/γ2 8EFO-μ-PZM21-Gi1/β1/γ2 8EFL-μ-SR17018-Gi1/β1/γ2 8F7Q-μ-β-Endorphin-Gi1/β1/γ2 7U2K-μ-C6-guano-Gi1/β1/γ2 8EFQ-μ-Damgo-Gi1/β1/γ2 8F7S-δ-Deltorphin-Gi1/β1/γ2 8F7W-κ-Dynorphin-Gi1/β1/γ2
57.14Single6AKXA4R6AKX-CCR5-A4R
57.14Single6KUYPubChem 1457046436KUY-α2a-PubChem 145704643
57.14Single6OBAS-Alprenolol6OBA-β2-S-Alprenolol-GTPL11074
57.14Single7LD4Adenosine7LD4-A1-Adenosine-Gi2/β1/γ2
57.14Single7LJDDopamine7LJD-D1-Dopamine-Mevidalen-Gs/β1/γ1
57.14Single7SRSLSD7SRS-5-HT2B-LSD-Arrestin2
57.14Single7X2FDopamine7X2F-D1-Dopamine-Mevidalen-Gs/β1/γ2
57.14Single7XT8Serotonin7XT8-5-HT4-Serotonin-Gs/β1/γ2
57.14Single8EFOPZM218EFO-μ-PZM21-Gi1/β1/γ2
57.14Single8WC3SEP-3638568WC3-TA1-SEP-363856-chim(NtGi1-Gs)/β1/γ2
57.14Single8WC4ZH86518WC4-TA1-ZH8651-chim(NtGi1-Gs)/β1/γ2
57.14Single8WCA2-Phenylethylamine8WCA-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/β1/γ2
57.14Single8YUTAmthamine8YUT-H2-Amthamine-Gs/β1/γ2
57.14Single9MQJIsoquinuclidine9MQJ-μ-Isoquinuclidine
57.14Consensusa1_onOrthosteric Ligand7LD4-A1-Adenosine-Gi2/β1/γ2
57.14Consensusa1_on_gpOrthosteric Ligand7LD4-A1-Adenosine-Gi2/β1/γ2
57.14Consensusgq_histamineOrthosteric Ligand7DFL-H1-Histamine-chim(NtGi1L-Gq)/β1/γ2
57.14Consensush1_on_gpOrthosteric Ligand7DFL-H1-Histamine-chim(NtGi1L-Gq)/β1/γ2
56.25Single4RWDDIPP-NH24RWD-δ-DIPP-NH2-Na
56.25Single5OM4PubChem 1355666095OM4-A2A-PubChem 135566609-Na
56.25Single5TVNLSD5TVN-5-HT2B-LSD
56.25Single5WQCEMPA5WQC-OX2-EMPA
56.25Single6PS6Timolol6PS6-β2-Timolol
56.25Single7LD3Adenosine7LD3-A1-Adenosine-PubChem 25263603-Gi2/β1/γ2
56.25Single7SBFPZM217SBF-μ-PZM21-Gi1/β1/γ2
56.25Single8JXSPF-61428JXS-D1-PF-6142
56.25Single9F34FOB02-04A9F34-D3-FOB02-04A-Go1/β1/γ2
56.25Consensush1_offOrthosteric Ligand8X63-H1-Mepyramine 3RZE-H1-Cidoxepin 8X5Y-H1-Astemizole
55.56Single5TUDErgotamine5TUD-5-HT2B-Ergotamine
55.56Single5X93K-87945X93-ETB-K-8794
55.56Single6BQGErgotamine6BQG-5-HT2C-Ergotamine
55.56Single6DDFDamgo6DDF-μ-Damgo-Gi1/β1/γ2
55.56Single7SK8CCX6627SK8-ACKR3-CXCL12-CCX662
55.56Single7UM4AS26747237UM4-5-HT5A-AS2674723
55.56Single7X2DTavapadon7X2D-D1-Tavapadon-Gs/β1/γ2
55.56Single7XJISolabegron7XJI-β3-Solabegron-Gs/β1/γ2
55.56Single8E9X2-Deoxycytidine8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/β1/γ2
55.56Single8E9YClozapine-N-oxide8E9Y-M3-Clozapine-N-oxide-chim(NtGi2L-Gs-CtGq)/β1/γ2
55.56Single8FX5Xanomeline8FX5-M4-Xanomeline-Xanomeline-Gi1/β1/γ2
55.56Consensusclass-a_onOrthosteric Ligandsensory_on alicarboxylic_on amine_on lipid_on nucleotide_on peptide_on protein_on
55.56Consensusendothelin_offOrthosteric Ligandetb_off
55.56Consensusetb_offOrthosteric Ligand5X93-ETB-K-8794 5XPR-ETB-Bosentan 6K1Q-ETB-IRL2500
55.56Consensuskop_on_gpOrthosteric Ligand8F7W-κ-Dynorphin-Gi1/β1/γ2 8DZS-κ-GR89,696-chim(NtGi2-Gz)/β1/γ2 8DZP-κ-momSalB-Gi1/β1/γ2
53.85Single7EJKOxymetazoline7EJK-α2a-Oxymetazoline-Go/β1/γ2
53.85Single8GGEConstrained Epinephrine8GGE-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
53.85Single8GH1Constrained Epinephrine8GH1-β2-Constrained Epinephrine
53.85Single8WC9ZH86518WC9-TA1-ZH8651-chim(NtGi1-Gs-CtGq)/β1/γ2
53.33Single3UZC4-(3-amino-5-phenyl-1,2,4-triazin-6-yl)-2-chlorophenol3UZC-A2A-4-(3-amino-5-phenyl-1,2,4-triazin-6-yl)-2-chlorophenol
53.33Single4DKLBeta-Funaltrexamine4DKL-μ-β-Funaltrexamine
53.33Single4MBSMaraviroc4MBS-CCR5-Maraviroc
53.33Single4ZJCSB-6740424ZJC-OX1-SB-674042
53.33Single6A94Zotepine6A94-5-HT2A-Zotepine
53.33Single6KUXRS-799486KUX-α2a-RS-79948
53.33Single6WH4Methiothepin6WH4-5-HT2A-Methiothepin
53.33Single7CKWFenoldopam7CKW-D1-Fenoldopam-Gs/β1/γ2
53.33Single7CMVPD1289077CMV-D3-PD128907-Gi1/β1/γ2
53.33Single7F0TDopamine7F0T-D1-Dopamine-Gs/β1/γ2
53.33Single7F1ZDopamine7F1Z-D1-Dopamine-GDP-Gs/β1/γ2
53.33Single7SR8TAK-9257SR8-OX2-TAK-925-chim(NtGi1L-Gs-CtGq)/β1/γ2
53.33Single7UL3Famotidine7UL3-H2-Famotidine
53.33Single7UM7Methylergometrine7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/β1/γ2
53.33Single8JLKUlotaront8JLK-TA1-Ulotaront-chim(NtGi1-Gs)/β1/γ2
53.33Single8JSPUlotaront8JSP-5-HT1A-Ulotaront-Gi1/β1/γ2
53.33Single8K9KDamgo8K9K-μ-Damgo-Gi3/β1/γ1
53.33Single8UHBRO52563908UHB-TA1-RO5256390-Gs/β1/γ2
53.33Single8V6UPubChem 1713924568V6U-5-HT2A-PubChem 171392456-chim(NtGi2-Gs-CtGq)/β1/γ2
53.33Single8W88SEP-3638568W88-TA1-SEP-363856-Gs/β1/γ2
53.33Single8W8BSEP-3638568W8B-5-HT1A-SEP-363856-Gi1/β1/γ2
53.33Single8WC8ZH86518WC8-TA1-ZH8651-chim(NtGi1-Gs)/β1/γ2
53.33Single8Y45ADL58598Y45-δ-ADL5859-Gi2/β1/γ2
53.33Single8YN3Histamine8YN3-H2-Histamine-Gs/β1/γ2
53.33Single8YN8Proxyfan8YN8-H3-Proxyfan-Go1/β1/γ2
53.33Single9BJKNaloxone9BJK-μ-Naloxone-NAM
53.33Single9JKQMETH9JKQ-TA1-METH-Gs/β1/γ2
53.33Single9MQIIsoquinuclidine9MQI-μ-Isoquinuclidine
53.33Consensusadenosine_onOrthosteric Liganda1_on a2_on a3_on
53.33Consensusgi_adenosineOrthosteric Ligand7LD4-A1-Adenosine-Gi2/β1/γ2 8X17-A3A-Namodenoson-Gi1/β1/γ2 8X16-A3A-Piclidenoson-Gi1/β1/γ2
53.33Consensusnop_offOrthosteric Ligand4EA3-NOP-PubChem 10296561 5DHG-NOP-C-35 5DHH-NOP-SB-612111
52.94Single3PDSHydroxybenzylisoproterenol3PDS-β2-Hydroxybenzylisoproterenol
52.94Single4U15Tiotropium4U15-M3-Tiotropium
52.94Single5ZKBAF-DX 3845ZKB-M2-AF-DX 384
52.94Single6DDEDamgo6DDE-μ-Damgo-Gi1/β1/γ2
52.94Single6J21Aprepitant6J21-NK1-Aprepitant
52.94Single6OL9Tiotropium6OL9-M5-Tiotropium
52.94Single7CKYPW04647CKY-D1-PW0464-Gs/β1/γ2
52.94Single7E2ZAripiprazole7E2Z-5-HT1A-Aripiprazole-Gi1/β1/γ2
52.94Single7T2HLofentanil7T2H-μ-Lofentanil-Gi1/β1/γ2
52.94Single7U2LPubChem 1632012427U2L-μ-PubChem 163201242-Gi1/β1/γ2
52.94Single7XY7NECA7XY7-A2B-NECA-chim(NtGi1-Gs)/β1/γ2
52.94Single8JT6(R)-IHCH-71798JT6-5-HT1A-(R)-IHCH-7179-Gi1/β1/γ2
52.94Single8T1VPubChem 1183102098T1V-GPR6-PubChem 118310209-Na
52.94Single8UGWPubChem 30865998UGW-A2A-PubChem 3086599
52.94Single9F33FOB02-04A9F33-D3-FOB02-04A-Go1/β1/γ2
52.94Consensus5ht_offOrthosteric Ligand5ht2_off 5ht1_off
52.94Consensusa2_onOrthosteric Liganda2b_on
52.94Consensusa2_on_gpOrthosteric Liganda2b_on_gp
52.94Consensusa2b_onOrthosteric Ligand8HDP-A2B-Adenosine-Gs/β1/γ2 7XY6-A2B-BAY 60-6583-chim(NtGi1-Gs)/β1/γ2 7XY7-A2B-NECA-chim(NtGi1-Gs)/β1/γ2 8HDO-A2B-BAY 60-6583-Gs/β1/γ2
52.94Consensusa2b_on_gpOrthosteric Ligand8HDP-A2B-Adenosine-Gs/β1/γ2 7XY6-A2B-BAY 60-6583-chim(NtGi1-Gs)/β1/γ2 7XY7-A2B-NECA-chim(NtGi1-Gs)/β1/γ2 8HDO-A2B-BAY 60-6583-Gs/β1/γ2
52.94Consensusgs_adenosineOrthosteric Ligand8HDP-A2B-Adenosine-Gs/β1/γ2 8HDO-A2B-BAY 60-6583-Gs/β1/γ2 7XY7-A2B-NECA-chim(NtGi1-Gs)/β1/γ2 7XY6-A2B-BAY 60-6583-chim(NtGi1-Gs)/β1/γ2
52.94Consensusgs_nucleotideOrthosteric Ligandgs_adenosine
52.94Consensusm5_offOrthosteric Ligand6OL9-M5-Tiotropium
52.94Consensusmuscarinic_offOrthosteric Ligandm2_off m3_off m4_off m5_off m1_off
52.94Consensustachykinin_offOrthosteric Ligandnk1_off
52.63Single6G79Donitriptan6G79-5-HT1B-Donitriptan-Go/β1/γ2
52.63Single6PT3DPI-2876PT3-δ-DPI-287
52.63Single7XY6BAY 60-65837XY6-A2B-BAY 60-6583-chim(NtGi1-Gs)/β1/γ2
52.63Single8JLRA776368JLR-TA1-A77636-chim(NtGi1-Gs)/β1/γ2
52.38Single6PT2KGCHM076PT2-δ-KGCHM07
52.38Consensusgs_class-aOrthosteric Ligandgs_peptide gs_nucleotide gs_amine
50.00Single2Y01Dobutamine2Y01-β1-Dobutamine
50.00Single4EJ4Naltrindole4EJ4-δ-Naltrindole
50.00Single4U16N-Methyl-Scopolamine4U16-M3-N-Methyl-Scopolamine
50.00Single5CXVTiotropium5CXV-M1-Tiotropium
50.00Single5DHGC-355DHG-NOP-C-35
50.00Single5DHHSB-6121115DHH-NOP-SB-612111
50.00Single5OLZPubChem 1355666095OLZ-A2A-PubChem 135566609-Na
50.00Single5OM1PubChem 1355666095OM1-A2A-PubChem 135566609-Na
50.00Single5YC8N-Methyl-Scopolamine5YC8-M2-N-Methyl-Scopolamine
50.00Single5ZK8N-Methyl-Scopolamine5ZK8-M2-N-Methyl-Scopolamine
50.00Single5ZKCN-Methyl-Scopolamine5ZKC-M2-N-Methyl-Scopolamine
50.00Single6A93Risperidone6A93-5-HT2A-Risperidone
50.00Single6CM4Risperidone6CM4-D2-Risperidone
50.00Single6DRZMethysergide6DRZ-5-HT2B-Methysergide
50.00Single6TOTLemborexant6TOT-OX1-Lemborexant
50.00Single7DFLHistamine7DFL-H1-Histamine-chim(NtGi1L-Gq)/β1/γ2
50.00Single7DH5Mirabegron7DH5-β3-Mirabegron-Gs/β1/γ2
50.00Single7EXDLasmiditan7EXD-5-HT1F-Lasmiditan-Gi1/β1/γ2
50.00Single7JOZVFP7JOZ-D1-VFP-Gs/β1/γ2
50.00Single7SCGFH2107SCG-μ-FH210-Gi1/β1/γ2
50.00Single7SQOTAK-9257SQO-OX2-TAK-925-Gi1/β1/γ2
50.00Single7SRQLSD7SRQ-5-HT2B-LSD
50.00Single7T6VfMLFII7T6V-FPR2-ALX-fMLFII-Gi1/β1/γ2
50.00Single7W0PElabela7W0P-Apelin-Elabela-Gi1/β1/γ2
50.00Single7WVWfMYFINILTL7WVW-FPR2-ALX-fMYFINILTL-Gi2/β1/γ2
50.00Single7XMTJ-21567XMT-SST4-J-2156-Gi1/β1/γ2
50.00Single7XT9Serotonin7XT9-5-HT4-Serotonin-Gs/β1/γ2
50.00Single7XTASerotonin7XTA-5-HT4-Serotonin-Gi1/β1/γ2
50.00Single8CU7LJ-45178CU7-A2A-LJ-4517-Na
50.00Single8DPFLorcaserin8DPF-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/β1/γ2
50.00Single8DZSGR89,6968DZS-κ-GR89,696-chim(NtGi2-Gz)/β1/γ2
50.00Single8E9W2-Deoxycytidine8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/β1/γ2
50.00Single8EFQDamgo8EFQ-μ-Damgo-Gi1/β1/γ2
50.00Single8JLOUlotaront8JLO-TA1-Ulotaront-Gs/β1/γ2
50.00Single8JLZST19368JLZ-5-HT6-ST1936-Gs/β1/γ2
50.00Single8T1WCVN4248T1W-GPR6-CVN424
50.00Single8UH3Setiptiline8UH3-5-HT1E-Setiptiline-Gi1/β1/γ1
50.00Single8UO4Constrained Epinephrine8UO4-β2-Constrained Epinephrine-GTP; Mg-Gs/β1/γ2
50.00Single8X17Namodenoson8X17-A3A-Namodenoson-Gi1/β1/γ2
50.00Single8X63Mepyramine8X63-H1-Mepyramine
50.00Single8YH3N-methyladenosine8YH3-A3A-N-methyladenosine-Gi1/β1/γ2
50.00Single8YN5Histamine8YN5-H3-Histamine-Gi1/β1/γ2
50.00Single8YN6Imetit8YN6-H3-Imetit-Gi1/β1/γ2
50.00Single8YN7Immethridine8YN7-H3-Immethridine-Go1/β1/γ2
50.00Single8YUVImmepip8YUV-H3-Immepip-Gi1/β1/γ2
50.00Single9BKKCholecystokinin-89BKK-CCKA-Cholecystokinin-8-chim(NtGi1-Gs-CtGq)/β1/γ2
50.00Single9D61JDTic9D61-κ-JDTic-Gi1/β1/γ2
50.00Consensus5ht1f_onOrthosteric Ligand7EXD-5-HT1F-Lasmiditan-Gi1/β1/γ2
50.00Consensus5ht1f_on_gpOrthosteric Ligand7EXD-5-HT1F-Lasmiditan-Gi1/β1/γ2
50.00Consensus5ht2b_offOrthosteric Ligand6DRZ-5-HT2B-Methysergide
50.00Consensus5ht4_onOrthosteric Ligand7XTA-5-HT4-Serotonin-Gi1/β1/γ2
50.00Consensus5ht4_on_gpOrthosteric Ligand7XTA-5-HT4-Serotonin-Gi1/β1/γ2
50.00Consensus5ht6_onOrthosteric Ligand7XTB-5-HT6-Serotonin-Gs/β1/γ2 8JLZ-5-HT6-ST1936-Gs/β1/γ2
50.00Consensus5ht6_on_gpOrthosteric Ligand7XTB-5-HT6-Serotonin-Gs/β1/γ2 8JLZ-5-HT6-ST1936-Gs/β1/γ2
50.00Consensusa3_onOrthosteric Liganda3a_on
50.00Consensusdop_offOrthosteric Ligand4EJ4-δ-Naltrindole
50.00Consensusgi_amineOrthosteric Ligandgi_5ht gi_muscarinic gi_adrenergic gi_dopamine gi_histamine
50.00Consensusgi_class-aOrthosteric Ligandgi_peptide gi_sensory gi_alicarboxylic gi_amine gi_lipid gi_nucleotide gi_protein
50.00Consensusgi_orexinOrthosteric Ligand7SQO-OX2-TAK-925-Gi1/β1/γ2
50.00Consensusgq_amineOrthosteric Ligandgq_muscarinic gq_histamine
50.00Consensush1_onOrthosteric Ligand7DFL-H1-Histamine-chim(NtGi1L-Gq)/β1/γ2
50.00Consensushistamine_offOrthosteric Ligandh1_off
50.00Consensusm1_offOrthosteric Ligand5CXV-M1-Tiotropium
47.83Single8XGOTAK4488XGO-Kiss1-TAK448-chim(NtGi1-Gq)/β1/γ2
47.83Consensusopioid_onOrthosteric Ligandmop_on nop_on dop_on kop_on
47.62Single3QAKUK-4320973QAK-A2A-UK-432097
47.62Single6HLOAprepitant6HLO-NK1-Aprepitant
47.62Single7CUMPhospholipid7CUM-GABAB1, GABAB2-CGP54626-Phospholipid
47.37Single5UNGPubChem 157800525UNG-AT2-PubChem 15780052
47.37Single7EZCUKA7EZC-A2A-UKA
47.37Single7VGY2-Iodomelatonin7VGY-MT1-2-Iodomelatonin-Gi1/β1/γ2
47.37Single7X1UTRH7X1U-TRH-TRH-chim(NtGi2L-Gs-CtGq)/β1/γ2
47.37Single8J19LY2378J19-GPR84-LY237-Gi1/β1/γ2
47.37Single8XIOL7975918XIO-SST1-L797591-chim(NtGi1-Gs-CtGi1)/β1/γ2
47.37Consensusorexin_on_gpOrthosteric Ligandox2_on_gp
47.06Single2Y00Dobutamine2Y00-β1-Dobutamine
47.06Single4ZJ8Suvorexant4ZJ8-OX1-Suvorexant
47.06Single6GDGNECA6GDG-A2A-NECA-Gs/β1/γ1
47.06Single6ME72-Phenylmelatonin6ME7-MT2-2-Phenylmelatonin
47.06Single6ME82-Phenylmelatonin6ME8-MT2-2-Phenylmelatonin
47.06Single6TO7Suvorexant6TO7-OX1-Suvorexant-Na
47.06Single6TP6Filorexant6TP6-OX1-Filorexant
47.06Single7CFNINT-7777CFN-GPBA-INT-777-Gs/β1/γ2
47.06Single8C9WEtrumadenant8C9W-A2A-Etrumadenant
47.06Single8E9ZIperoxo8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/β1/γ2
47.06Single8EFBOliceridine8EFB-μ-Oliceridine-Gi1/β1/γ2
47.06Single8HNLPS3724248HNL-CXCR3-PS372424-Gi1/β1/γ2
47.06Single8S4DCMF-0198S4D-Apelin-CMF-019
47.06Single8TF5Oleic acid8TF5-GPR6-Oleic acid
47.06Single8VVEnorBNI8VVE-κ-norBNI-Gi1/β1/γ2
47.06Single8XYKVUF106618XYK-CXCR3-VUF10661-Go1/β1/γ2
47.06Single8YH0NECA8YH0-A3A-NECA-Gi1/β1/γ2
47.06Single8ZMFA1L108ZMF-5-HT2C-A1L10
47.06Consensus5ht2_offOrthosteric Ligand5ht2a_off 5ht2b_off 5ht2c_off
47.06Consensusa3_on_gpOrthosteric Liganda3a_on_gp
47.06Consensusa3a_onOrthosteric Ligand8X17-A3A-Namodenoson-Gi1/β1/γ2 8X16-A3A-Piclidenoson-Gi1/β1/γ2
47.06Consensusa3a_on_gpOrthosteric Ligand8X17-A3A-Namodenoson-Gi1/β1/γ2 8X16-A3A-Piclidenoson-Gi1/β1/γ2
47.06Consensusm2_offOrthosteric Ligand5ZKC-M2-N-Methyl-Scopolamine 5ZK3-M2-3-quinuclidinyl-benzilate 5ZKB-M2-AF-DX 384
47.06Consensusm3_onOrthosteric Ligand8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/β1/γ2 8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/β1/γ2 8E9Y-M3-Clozapine-N-oxide-chim(NtGi2L-Gs-CtGq)/β1/γ2
47.06Consensusm3_on_gpOrthosteric Ligand8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/β1/γ2 8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/β1/γ2 8E9Y-M3-Clozapine-N-oxide-chim(NtGi2L-Gs-CtGq)/β1/γ2
46.67Single5WS3EMPA5WS3-OX2-EMPA
46.67Single6AKYMaraviroc6AKY-CCR5-Maraviroc
46.67Single6B73MP11046B73-κ-MP1104
46.67Single6TODEMPA6TOD-OX1-EMPA-Na
46.67Single7EJ0L-Norepinephrine7EJ0-α2a-L-Norepinephrine-Go/β1/γ2
46.67Single7F1ODopamine7F1O-D1-Dopamine-GDP; Mg-Gs/β1/γ2
46.67Single7SRRLSD7SRR-5-HT2B-LSD-chim(NtGi2L-Gs-CtGq)/β1/γ2
46.67Single7YM8Oxymetazoline7YM8-Alpha1A-Oxymetazoline-chim(Gs-CtGq)
46.67Single8FYXBuspirone8FYX-5-HT1A-Buspirone-Gi1/β1/γ1
46.67Single8HDPAdenosine8HDP-A2B-Adenosine-Gs/β1/γ2
46.67Single8IW4Spermidine8IW4-TA9-Spermidine-chim(NtGi1-Gs)/β1/γ2
46.67Single8IWESpermidine8IWE-TA9-Spermidine
46.67Single8JSOAMPH8JSO-TA1-AMPH-chim(NtGi1-Gs)/β1/γ2
46.67Consensus5ht2_on_gpOrthosteric Ligand5ht2b_on_gp
46.67Consensus5ht2b_on_gpOrthosteric Ligand7SRR-5-HT2B-LSD-chim(NtGi2L-Gs-CtGq)/β1/γ2
46.67Consensushistamine_onOrthosteric Ligandh1_on h2_on h3_on h4_on
46.67Consensushistamine_on_gpOrthosteric Ligandh1_on_gp h2_on_gp h3_on_gp h4_on_gp
46.67Consensusorexin_offOrthosteric Ligandox2_off ox1_off
46.67Consensusox1_offOrthosteric Ligand6TP6-OX1-Filorexant 6TP4-OX1-ACT-462206 6V9S-OX1-GTPL11403 6TOT-OX1-Lemborexant 6TP3-OX1-Nemorexant 6TQ6-OX1-PubChem 145714283 6TQ9-OX1-SB-408124 4ZJC-OX1-SB-674042 4ZJ8-OX1-Suvorexant 6TOD-OX1-EMPA-Na 6TOS-OX1-GSK1059865-Na 6TQ4-OX1-PubChem 16046844-Na
46.67Consensusox2_offOrthosteric Ligand5WQC-OX2-EMPA 6TPN-OX2-HTL6641 7XRR-OX2-Lemborexant 6TPJ-OX2-Suvorexant
46.15Single8DPHLorcaserin8DPH-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/β1/γ2
46.15Single8GEIConstrained Epinephrine8GEI-β2-Constrained Epinephrine-Gs/β1/γ2
46.15Single8IWM2-Phenylethylamine8IWM-TA9-2-Phenylethylamine
46.15Single9CHUNoradrenaline9CHU-β2-Noradrenaline
46.15Consensusgs_histamineOrthosteric Ligand8POK-H2-Histamine-Gs/β1/γ2
46.15Consensush2_onOrthosteric Ligand8POK-H2-Histamine-Gs/β1/γ2
45.83Consensusopioid_on_gpOrthosteric Ligandmop_on_gp nop_on_gp dop_on_gp kop_on_gp
45.45Single5WF5UK-4320975WF5-A2A-UK-432097
45.45Single8XIQL7967788XIQ-SST3-L796778-chim(NtGi1-Gs-CtGi1)/β1/γ2
45.45Consensusgi_somatostatinOrthosteric Ligand7WIC-SST2-Somatostatin-14-Gi1/β1/γ2 7XMS-SST4-Somatostatin-14-Gi1/β1/γ2 8X8L-SST5-Cortistatin-chim(NtGi1-Gs-CtGi1)/β1/γ2 7XMT-SST4-J-2156-Gi1/β1/γ2 7WIG-SST2-L-054,264-Gi1/β1/γ2 8X8N-SST5-Octreotide-chim(NtGi1-Gs-CtGi1)/β1/γ2 7YAE-SST2-Octreotide-Gi1/β1/γ2 7YAC-SST2-Paltusotine-Gi1/β1/γ2
45.45Consensuspeptide_offonOrthosteric Ligandpeptide_off peptide_on
45.45Consensussomatostatin_onOrthosteric Ligandsst2_on sst4_on sst5_on
45.45Consensussomatostatin_on_gpOrthosteric Ligandsst2_on_gp sst4_on_gp sst5_on_gp
45.00Single5WF6UK-4320975WF6-A2A-UK-432097
45.00Single7SK9CCX6627SK9-ACKR3-CCX662
45.00Single7XN9L-054,5227XN9-SST2-L-054,522
45.00Consensusdop_onOrthosteric Ligand8F7S-δ-Deltorphin-Gi1/β1/γ2
45.00Consensusox2_onOrthosteric Ligand7L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/β1/γ2 7SQO-OX2-TAK-925-Gi1/β1/γ2 7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/β1/γ2
45.00Consensusox2_on_gpOrthosteric Ligand7L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/β1/γ2 7SQO-OX2-TAK-925-Gi1/β1/γ2 7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/β1/γ2
45.00Consensussst2_onOrthosteric Ligand7WIC-SST2-Somatostatin-14-Gi1/β1/γ2 7WIG-SST2-L-054,264-Gi1/β1/γ2 7YAE-SST2-Octreotide-Gi1/β1/γ2 7YAC-SST2-Paltusotine-Gi1/β1/γ2
45.00Consensussst2_on_gpOrthosteric Ligand7WIC-SST2-Somatostatin-14-Gi1/β1/γ2 7WIG-SST2-L-054,264-Gi1/β1/γ2 7YAE-SST2-Octreotide-Gi1/β1/γ2 7YAC-SST2-Paltusotine-Gi1/β1/γ2
44.44Single4DJHJDTic4DJH-κ-JDTic
44.44Single4IAQDihydroergotamine4IAQ-5-HT1B-Dihydroergotamine
44.44Single5V54Methiothepin5V54-5-HT1B-Methiothepin
44.44Single6J20Aprepitant6J20-NK1-Aprepitant
44.44Single6KO5PubChem 574000026KO5-Ghrelin-PubChem 57400002
44.44Single7EW1Siponimod7EW1-S1P5-Siponimod-Gi1/β1/γ2
44.44Single7TRQIperoxo7TRQ-M4-Iperoxo-VU0467154-Gi1/β1/γ2
44.44Single8EA0Iperoxo8EA0-M3-Iperoxo
44.44Single8EF5Fentanyl8EF5-μ-Fentanyl-Gi1/β1/γ2
44.44Single8EFLSR170188EFL-μ-SR17018-Gi1/β1/γ2
44.44Single8HDOBAY 60-65838HDO-A2B-BAY 60-6583-Gs/β1/γ2
44.44Single8HPTC5a anaphylatoxin C-terminal peptide8HPT-C5a1-C5a anaphylatoxin C-terminal peptide-Go/β1/γ2
44.44Single8ID39-Hydroxystearic acid8ID3-FFA4-9-Hydroxystearic acid-Gi1/β1/γ2
44.44Single8IYHMK68928IYH-HCA2-MK6892-Go/β1/γ2
44.44Single8JLPRalmitaront8JLP-TA1-Ralmitaront-Gs/β1/γ2
44.44Single8JXVClozapine8JXV-H4-Clozapine-Gi1/β1/γ2
44.44Single8XVLZibotentan8XVL-ETA-Zibotentan
44.44Single8YH6Namodenoson8YH6-A3A-Namodenoson-Gi1/β1/γ2
44.44Consensus5ht1_offOrthosteric Ligand5ht1b_off
44.44Consensus5ht1b_offOrthosteric Ligand5V54-5-HT1B-Methiothepin
44.44Consensusclass-a_offOrthosteric Ligandsensory_off alicarboxylic_off amine_off lipid_off nucleotide_off peptide_off protein_off
44.44Consensuskop_offOrthosteric Ligand4DJH-κ-JDTic
44.44Consensusm3_offOrthosteric Ligand4U15-M3-Tiotropium 4U16-M3-N-Methyl-Scopolamine 5ZHP-M3-PubChem 134828589
44.44Consensuss1p5_onOrthosteric Ligand7EW1-S1P5-Siponimod-Gi1/β1/γ2
44.44Consensuss1p5_on_gpOrthosteric Ligand7EW1-S1P5-Siponimod-Gi1/β1/γ2
44.00Consensusgq_peptideOrthosteric Ligandgq_cck gq_kisspeptin gq_bradykinin gq_bombesin gq_angiotensin
43.75Single2YDOAdenosine2YDO-A2A-Adenosine
43.75Single3RZECidoxepin3RZE-H1-Cidoxepin
43.75Single4MQTIperoxo4MQT-M2-Iperoxo-LY2119620
43.75Single4N6HNaltrindole4N6H-δ-Naltrindole-Na
43.75Single6IQLL7458706IQL-D4-L745870
43.75Single6ME32-Phenylmelatonin6ME3-MT1-2-Phenylmelatonin
43.75Single6PS82-Phenylmelatonin6PS8-MT1-2-Phenylmelatonin
43.75Single6TOSGSK10598656TOS-OX1-GSK1059865-Na
43.75Single6TPNHTL66416TPN-OX2-HTL6641
43.75Single6V9SGTPL114036V9S-OX1-GTPL11403
43.75Single6VI4JDTic6VI4-κ-JDTic
43.75Single6WJCAtropine6WJC-M1-Atropine-Muscarinic toxin 7
43.75Single6ZFZ77-LH-28-16ZFZ-M1-77-LH-28-1
43.75Single7T94Acetylcholine7T94-M2-Acetylcholine-PubChem 57664406-chim(NtGi1-Go)/β1/γ2
43.75Single7TRSAcetylcholine7TRS-M4-Acetylcholine-Gi1/β1/γ2
43.75Single7WC9PubChem 1624213647WC9-5-HT2A-PubChem 162421364
43.75Single8DPGPsilocin8DPG-5-HT2C-Psilocin-chim(NtGi2L-Gs-CtGq)/β1/γ2
43.75Single8JLQFenoldopam8JLQ-TA1-Fenoldopam-Gs/β1/γ2
43.75Single8VVGGB188VVG-κ-GB18-Gi1/β1/γ2
43.75Single8ZMGPimavanserin8ZMG-5-HT2A-Pimavanserin
43.48Consensuspeptide_offon_gpOrthosteric Ligandpeptide_on_gp peptide_off
42.86Single3UZAGTPL92363UZA-A2A-GTPL9236
42.86Single5UNFPubChem 157800525UNF-AT2-PubChem 15780052
42.86Single6FUFAll-trans-Retinal6FUF-Rhodopsin-All-trans-Retinal-Go
42.86Single7WKDTRH7WKD-TRH-TRH-chim(NtGi1-Gs-CtGq)/β1/γ2
42.86Single7XAUOctreotide7XAU-SST2-Octreotide-Gi1/β1/γ2
42.86Single8DPILorcaserin8DPI-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/β1/γ2
42.86Single8GGFConstrained Epinephrine8GGF-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
42.86Single8IW72-Phenylethylamine8IW7-TA9-2-Phenylethylamine-chim(NtGi1-Gs)/β1/γ2
42.86Single8POKHistamine8POK-H2-Histamine-Gs/β1/γ2
42.86Single8WC62-Phenylethylamine8WC6-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/β1/γ2
42.86Single8YN9Histamine8YN9-H4-Histamine-Gi1/β1/γ2
42.86Single8YUUHistamine8YUU-H3-Histamine-Gi1/β1/γ1
42.86Consensus5ht2_onOrthosteric Ligand5ht2b_on
42.86Consensus5ht2b_onOrthosteric Ligand7SRR-5-HT2B-LSD-chim(NtGi2L-Gs-CtGq)/β1/γ2
42.86Consensush2_on_gpOrthosteric Ligand8POK-H2-Histamine-Gs/β1/γ2
42.86Consensush3_onOrthosteric Ligand8YUU-H3-Histamine-Gi1/β1/γ1
42.86Consensush3_on_gpOrthosteric Ligand8YUU-H3-Histamine-Gi1/β1/γ1
42.11Single5UNHPubChem 1264564065UNH-AT2-PubChem 126456406
42.11Single6ZG4HTL00099366ZG4-M1-HTL0009936
42.11Single7DFPSpiperone7DFP-D2-Spiperone
42.11Single7JNIOlodanrigan7JNI-AT2-Olodanrigan
42.11Single7L1VPubChem 1554910097L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/β1/γ2
42.11Single7SUSPubChem 1227019087SUS-Apelin-PubChem 122701908
42.11Single7W0LPubChem 1227019087W0L-Apelin-PubChem 122701908-Gi1/β1/γ2
42.11Single7W0LPubChem 1227019087W0L-Apelin-PubChem 122701908-Gi1/β1/γ2
42.11Single7WCNAR2314537WCN-GPR119-AR231453-Gs/β1/γ2
42.11Single7XW9TRH7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/β1/γ2
42.11Single8G056-OAU8G05-GPR84-6-OAU-Gi1/β1/γ2
42.11Single8I9AEP548I9A-C3aB-EP54-chim(NtGi1-Gs-CtGq)/β1/γ2
42.11Single8IA8E7 peptide8IA8-C3aB-E7 peptide-Gi1/β1/γ2
42.11Single8JWZAB9288JWZ-A2A-AB928-Na
42.11Single8JZ7MK68928JZ7-HCA2-MK6892-Gi1/β1/γ2
42.11Single8W1VPubChem 1717162658W1V-β2-PubChem 171716265
42.11Single8XYIVUF106618XYI-CXCR3-VUF10661
42.11Single9GYOP3959GYO-GPBA-P395-chim(NtGi1-Gs)/β1/γ2
42.11Consensusgi_lipidOrthosteric Ligandgi_cannabinoid gi_ffa gi_leukotriene gi_lpa gi_s1p
42.11Consensusgi_muscarinicOrthosteric Ligand8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/β1/γ2 7T8X-M2-Acetylcholine-chim(NtGi1-Go)/β1/γ2 7TRS-M4-Acetylcholine-Gi1/β1/γ2 7TRK-M4-Iperoxo-Gi1/β1/γ2 7V6A-M4-PubChem 9864275-Gi1/β1/γ2
42.11Consensusorexin_onOrthosteric Ligandox2_on
42.11Consensustrh_onOrthosteric Ligand7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/β1/γ2
42.11Consensustrh_on_gpOrthosteric Ligand7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/β1/γ2
41.67Single8ZPSPrRP208ZPS-PrRP-PrRP20-chim(NtGi1-Gs-CtGq)/β1/γ2
41.67Consensussst5_on_gpOrthosteric Ligand8X8L-SST5-Cortistatin-chim(NtGi1-Gs-CtGi1)/β1/γ2 8X8N-SST5-Octreotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
41.18Single4DAJTiotropium4DAJ-M3-Tiotropium
41.18Single4J4QOctyl Beta-D-Glucopyranoside4J4Q-Rhodopsin-Octyl β-D-Glucopyranoside-Gt(CT)
41.18Single4MQSIperoxo4MQS-M2-Iperoxo
41.18Single4U14Tiotropium4U14-M3-Tiotropium
41.18Single4X1HNonyl-Beta-D-Glucopyranoside4X1H-Rhodopsin-Nonyl-β-D-Glucopyranoside-Gt(CT)
41.18Single5DSGTiotropium5DSG-M4-Tiotropium
41.18Single5UIGCmpd-15UIG-A2A-Cmpd-1
41.18Single6WHADB139486WHA-5-HT2A-DB13948-chim(NtGi2L-Gs-CtGq)/β1/γ2
41.18Single7TRPIperoxo7TRP-M4-Iperoxo-LY2033298-Gi1/β1/γ2
41.18Single7VGZRemalteon7VGZ-MT1-Remalteon-Gi1/β1/γ2
41.18Single7VIES1P7VIE-S1P1-S1P-Gi1/β1/γ2
41.18Single8CICEtrumadenant8CIC-A2A-Etrumadenant-Na
41.18Single8CU6LJ-45178CU6-A2A-LJ-4517
41.18Single8JD0NAM5638JD0-mGlu2; mGlu3-Glutamate-NAM563
41.18Single8UWLLisuride8UWL-5-HT2A-Lisuride-chim(NtGi2-Gs-CtGq)/β1/γ2
41.18Single8YH5Riboprine8YH5-A3A-Riboprine-Gi1/β1/γ2
41.18Consensusalicarboxylic_on_gpOrthosteric Ligandsuccinate_on_gp hca_on_gp
41.18Consensusgi_alicarboxylicOrthosteric Ligandgi_hca gi_succinate
41.18Consensusm4_offOrthosteric Ligand5DSG-M4-Tiotropium
41.18Consensusmuscarinic_onOrthosteric Ligandm2_on m3_on m4_on m1_on
41.18Consensusmuscarinic_on_gpOrthosteric Ligandm2_on_gp m3_on_gp m4_on_gp m1_on_gp
40.91Single6DO1Angiotensin-like peptide S1I86DO1-AT1-Angiotensin-like peptide S1I8
40.91Single7DDZJNJ-310200287DDZ-Y2-JNJ-31020028
40.91Single7XMSSomatostatin-147XMS-SST4-Somatostatin-14-Gi1/β1/γ2
40.91Single8F7SDeltorphin8F7S-δ-Deltorphin-Gi1/β1/γ2
40.91Single8SG1Chemerin-98SG1-CML1-Chemerin-9-Gi1/β1/γ2
40.91Consensusdop_on_gpOrthosteric Ligand8F7S-δ-Deltorphin-Gi1/β1/γ2
40.91Consensusnpy2_offOrthosteric Ligand7DDZ-Y2-JNJ-31020028
40.91Consensuss1p3_on_gpOrthosteric Ligand7EW3-S1P3-S1P-Gi1/β1/γ2 7EW4-S1P3-CYM5541-Gi1/β1/γ2 7EW2-S1P3-Fingolimod-Gi1/β1/γ2
40.91Consensussst4_onOrthosteric Ligand7XMS-SST4-Somatostatin-14-Gi1/β1/γ2 7XMT-SST4-J-2156-Gi1/β1/γ2
40.91Consensussst4_on_gpOrthosteric Ligand7XMS-SST4-Somatostatin-14-Gi1/β1/γ2 7XMT-SST4-J-2156-Gi1/β1/γ2
40.00Single3VGAZM-2413853VGA-A2A-ZM-241385-Antibody
40.00Single4NC3Ergotamine4NC3-5-HT2B-Ergotamine
40.00Single6BQHRitanserin6BQH-5-HT2C-Ritanserin
40.00Single6HLLCP999946HLL-NK1-CP99994
40.00Single7F8VGastrin-177F8V-CCKB-Gastrin-17-Gi2/β1/γ2
40.00Single7MBYCholecystokinin-87MBY-CCKA-Cholecystokinin-8-chim(NtGi1L-Gs-CtGq)/β1/γ2
40.00Single7MTSADX551647MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/β1/γ2
40.00Single7SK7CCX6627SK7-ACKR3-CXCL12-CCX662
40.00Single7U2KC6-guano7U2K-μ-C6-guano-Gi1/β1/γ2
40.00Single7WVVfMLFII7WVV-FPR2-ALX-fMLFII-Gi2/β1/γ2
40.00Single7XK2MK68927XK2-HCA2-MK6892-Gi1/β1/γ2
40.00Single7YKDChemerin-97YKD-CML1-Chemerin-9-Gi1/β1/γ2
40.00Single8H2GNiacin8H2G-HCA2-Niacin-Gi1/β1/γ2
40.00Single8I95EP548I95-C3aB-EP54-Go/β1/γ2
40.00Single8IJDMK68928IJD-HCA2-MK6892-Gi1/β1/γ2
40.00Single8K2XCXCL108K2X-CXCR3-CXCL10-Gi1/β1/γ2
40.00Single8K5BNiacin8K5B-HCA2-Niacin
40.00Single8T3OTUG-8918T3O-FFA4-TUG-891-2Y5-chim(NtGi2L-Gs-CtGq)/β1/γ2
40.00Single8W89PEA8W89-TA1-PEA-chim(NtGi1L-Gs)/β1/γ2
40.00Single8YN2Histamine8YN2-H1-Histamine-chim(NtGi1L-Gs-CtGq)/β1/γ2
40.00Single8ZSVRO52633978ZSV-TA1-RO5263397-chim(NtGi1-Gs)/β1/γ2
40.00Single9J5VCpY9J5V-LPA1-CpY-Gi1/β1/γ2
40.00Single9L3ZLRH7-C29L3Z-CML1-LRH7-C2
40.00Consensus5ht2c_offOrthosteric Ligand6BQH-5-HT2C-Ritanserin
40.00Consensuscb1_on_gpOrthosteric Ligand6KPG-CB1-AM841-Gi1/β1/γ2 8K8J-CB1-Fenofibrate-chim(Gs-CtGq)/β1/γ2
40.00Consensusgi_peptideOrthosteric Ligandgi_cck gi_apelin gi_compl-pept gi_endothelin gi_formylpeptide gi_galanin gi_ghrelin gi_npy gi_neurotensin gi_opioid gi_orexin gi_relaxin gi_somatostatin
40.00Consensusgi_s1pOrthosteric Ligand7VIE-S1P1-S1P-Gi1/β1/γ2 7EW3-S1P3-S1P-Gi1/β1/γ2 7EVY-S1P1-Siponimod-Gi1/β1/γ2 7EW1-S1P5-Siponimod-Gi1/β1/γ2 7VIF-S1P1-S-FTY720-P-Gi1/β1/γ2 7VIG-S1P1-CBP-307-Gi1/β1/γ2 7EVZ-S1P1-Cenerimod-Gi1/β1/γ2 7EW4-S1P3-CYM5541-Gi1/β1/γ2 7EW2-S1P3-Fingolimod-Gi1/β1/γ2 7EW0-S1P1-Ozanimod-Gi1/β1/γ2 7EW7-S1P1-SEW2871-Gi1/β1/γ2
40.00Consensusnucleotide_on_gpOrthosteric Ligandadenosine_on_gp p2y_on_gp
40.00Consensuspeptide_offOrthosteric Ligandcck_off angiotensin_off bombesin_off endothelin_off ghrelin_off npy_off opioid_off orexin_off somatostatin_off tachykinin_off vasop-oxy_off neurotensin_off
39.13Single7T6TfMLFII7T6T-FPR1-ALX-fMLFII-Gi1/β1/γ2
39.13Single7TD0LPA7TD0-LPA1-LPA-Gi1/β1/γ2
39.13Single8XIRPasireotide8XIR-SST3-Pasireotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
39.13Single9B54A1AIW9B54-CB1-A1AIW-Gi1/β1/γ2
39.13Consensusangiotensin_onOrthosteric Ligandat1_on
39.13Consensusat1_onOrthosteric Ligand7F6G-AT1-SAR1-AngII-Gq/β1/γ2
38.89Single5NM2ZM-2413855NM2-A2A-ZM-241385-Na
38.89Single5XPRBosentan5XPR-ETB-Bosentan
38.89Single5ZK33-quinuclidinyl-benzilate5ZK3-M2-3-quinuclidinyl-benzilate
38.89Single6HLPNetupitant6HLP-NK1-Netupitant
38.89Single6LUQHaloperidol6LUQ-D2-Haloperidol
38.89Single6ME62-Phenylmelatonin6ME6-MT2-2-Phenylmelatonin
38.89Single6OIKIperoxo6OIK-M2-Iperoxo-LY2119620-chim(NtGi1-Go)/β1/γ2
38.89Single7EUOfMLF7EUO-FPR1-ALX-fMLF-Gi1/β1/γ2
38.89Single7TRKIperoxo7TRK-M4-Iperoxo-Gi1/β1/γ2
38.89Single7VUHJNJ-635330547VUH-GPR139-JNJ-63533054-chim(Gs-CtGq)/β1/γ2
38.89Single7WIGL-054,2647WIG-SST2-L-054,264-Gi1/β1/γ2
38.89Single8J18(3R)-3-Hydroxydodecanoic acid8J18-GPR84-(3R)-3-Hydroxydodecanoic acid-Gi1/β1/γ2
38.89Single8J6JGSK2560738J6J-HCA2-GSK256073-Gi1/β1/γ2
38.89Single8KFXLMD-0098KFX-CCR8-LMD-009-Gi1/β1/γ2
38.89Single8TH4Losartan8TH4-AT1-Losartan-AT118-L Nanobody
38.89Single8ZRKGSK-12922638ZRK-GPR119-GSK-1292263-Gs/β1/γ2
38.89Single9AVLCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVL-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi3/β2/γ2
38.89Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
38.89Single9EAHOlmesartan9EAH-AT1-Olmesartan-Nanobody AT209
38.89Consensusadenosine_offOrthosteric Liganda1_off a2_off
38.89Consensuscb2_onOrthosteric Ligand8GUR-CB2-CP55,940-Gi1/β1/γ2 8GUS-CB2-HU-308-Gi1/β1/γ2 8GUT-CB2-LEI-102-Gi1/β1/γ2 6KPF-CB2-PubChem 145915889-Gi1/β1/γ2 6PT0-CB2-WIN 55212-2-Gi1/β1/γ2 8GUQ-CB2-Olorinab-Gi1/β1/γ2
38.89Consensuscb2_on_gpOrthosteric Ligand8GUR-CB2-CP55,940-Gi1/β1/γ2 8GUS-CB2-HU-308-Gi1/β1/γ2 8GUT-CB2-LEI-102-Gi1/β1/γ2 6KPF-CB2-PubChem 145915889-Gi1/β1/γ2 6PT0-CB2-WIN 55212-2-Gi1/β1/γ2 8GUQ-CB2-Olorinab-Gi1/β1/γ2
38.89Consensusnucleotide_onOrthosteric Ligandadenosine_on p2y_on
38.46Single7WVYAmyloid-Beta427WVY-FPR2-ALX-Amyloid-β42-Gi2/β1/γ2
38.46Single8FEG(DNCP)-Beta-Naloxamine8FEG-κ-(DNCP)-β-Naloxamine-Gi1/β1/γ2
38.46Single8ZH8QRF-Amide8ZH8-QRFP-QRF-Amide-Gq/β1/γ1
38.46Single9K26PrRP319K26-PrRP-PrRP31-Gi1/β1/γ2
38.46Consensuspeptide_onOrthosteric Ligandcck_on angiotensin_on apelin_on bombesin_on bradykinin_on compl-peptide_on endothelin_on formylpeptide_on galanin_on ghrelin_on kisspeptin_on melanocortin_on motilin_on neuromedin-u_on npy_on neurotensin_on opioid_on orexin_on relaxin_on somatostatin_on tachykinin_on trh_on vasop-oxy_on
38.46Consensuspeptide_on_gpOrthosteric Ligandcck_on_gp angiotensin_on_gp apelin_on_gp bombesin_on_gp bradykinin_on_gp compl-peptide_on_gp endothelin_on_gp formylpeptide_on_gp galanin_on_gp ghrelin_on_gp kisspeptin_on_gp melanocortin_on_gp motilin_on_gp neuromedin-u_on_gp npy_on_gp neurotensin_on_gp opioid_on_gp orexin_on_gp relaxin_on_gp somatostatin_on_gp tachykinin_on_gp trh_on_gp vasop-oxy_on_gp
38.10Single5ZTYAM102575ZTY-CB2-AM10257
38.10Single7F2OBradykinin7F2O-BK2-Bradykinin-chim(NtGi1-Gs-CtGq)/β1/γ2
38.10Single7F8WGastrin-177F8W-CCKB-Gastrin-17-chim(NtGsL-Gq)/β1/γ2
38.10Single7T11Octreotide7T11-SST2-Octreotide-Gi3/β1/γ2
38.10Single7YJ4INSL57YJ4-RXFP4-INSL5-Gi2/β1/γ2
38.10Single8F7REndomorphin8F7R-μ-Endomorphin-Gi1/β1/γ2
38.10Single8IA7Cholecystokinin-88IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/β1/γ2
38.10Single8X3LXWD8X3L-CB2-XWD-Gi1/β1/γ2
38.10Consensuscb2_offOrthosteric Ligand5ZTY-CB2-AM10257
38.10Consensuscxcr3_onOrthosteric Ligand8HNK-CXCR3-CXCL11-Gi1/β1/γ2 8HNL-CXCR3-PS372424-Gi1/β1/γ2
38.10Consensuss1p_onOrthosteric Ligands1p1_on s1p3_on s1p5_on
38.10Consensuss1p_on_gpOrthosteric Ligands1p1_on_gp s1p3_on_gp s1p5_on_gp
37.50Single2PED9-cis-Retinal2PED-Rhodopsin-9-cis-Retinal
37.50Single2X72All-trans-Retinal2X72-Rhodopsin-All-trans-Retinal-Gt(CT)
37.50Single4S0VSuvorexant4S0V-OX2-Suvorexant
37.50Single5K2DZM-2413855K2D-A2A-ZM-241385-Na
37.50Single5OLHVipadenant5OLH-A2A-Vipadenant-Na
37.50Single5OLOTozadenant5OLO-A2A-Tozadenant-Na
37.50Single5OLVLUAA410635OLV-A2A-LUAA41063-Na
37.50Single6D9HAdenosine6D9H-A1-Adenosine-Gi2/β1/γ2
37.50Single6JZHZM-2413856JZH-A2A-ZM-241385-Na
37.50Single6ME2Ramelteon6ME2-MT1-Ramelteon
37.50Single6NWEOctyl-Beta-D-Glucopyranoside6NWE-Rhodopsin-Octyl-β-D-Glucopyranoside-Gt(CT)
37.50Single6PS7ZM-2413856PS7-A2A-ZM-241385-Na
37.50Single6TPJSuvorexant6TPJ-OX2-Suvorexant
37.50Single7DW9AVP7DW9-V2-AVP-chim(NtGi1-Gs)/β1/γ2
37.50Single7F6GSAR1-AngII7F6G-AT1-SAR1-AngII-Gq/β1/γ2
37.50Single7F8ULintitript7F8U-CCKA-Lintitript
37.50Single7T6SPubChem 247763417T6S-FPR2-ALX-PubChem 24776341-Gi1/β1/γ2
37.50Single7T8XAcetylcholine7T8X-M2-Acetylcholine-chim(NtGi1-Go)/β1/γ2
37.50Single7T90Acetylcholine7T90-M2-Acetylcholine-chim(NtGi1-Go)/β1/γ2
37.50Single7T96Acetylcholine7T96-M2-Acetylcholine-LY2119620-Go/β1/γ2
37.50Single7VUJJNJ-635330547VUJ-GPR139-JNJ-63533054-GDP-chim(Gs-CtGq)/β1/γ2
37.50Single7W0MPubChem 1227019087W0M-Apelin-PubChem 122701908-Gi1/β1/γ2
37.50Single7W40Bombesin7W40-BB2-Bombesin-chim(NtGi1L-Gq)/β1/γ2
37.50Single7XRRLemborexant7XRR-OX2-Lemborexant
37.50Single8DU3PubChem 1055260648DU3-A2A-PubChem 105526064
37.50Single8DWGML3828DWG-MRGPRX1-Proenkephalin-A-ML382-chim(NtGi2L-Gs-CtGq)/β1/γ2
37.50Single8GNGIstradefylline8GNG-A2A-Istradefylline
37.50Single8H4KGW95088H4K-FFA4-GW9508-chim(NtGi1-Gs-CtGq)/β1/γ2
37.50Single8HOCImetit8HOC-H4-Imetit-Gi1/β1/γ2
37.50Single8IHFMK68928IHF-HCA2-MK6892-Gi1/β1/γ2
37.50Single8IJANiacin8IJA-HCA2-Niacin-Gi1/β1/γ2
37.50Single8J6IMK68928J6I-HCA2-MK6892-Gi1/β1/γ2
37.50Single8RW0Istradefylline8RW0-A2A-Istradefylline-Na
37.50Single8WOGSuccinic acid8WOG-Succinate-Succinic acid-Gi1/β1/γ2
37.50Single8XWQEndothelin-18XWQ-ETB-Endothelin-1-Gi1/β1/γ2
37.50Single8XXVIndomethacin8XXV-DP2-Indomethacin-A1D5Q-Gi1/β1/γ2
37.50Single8Y0HVUF114188Y0H-CXCR3-VUF11418
37.50Single8YKXMaleic acid8YKX-Succinate-Maleic acid-Gi1/β1/γ1
37.50Single8YNAImmepip8YNA-H4-Immepip-Gi1/β1/γ
37.50Consensusangiotensin_offOrthosteric Ligandat1_off
37.50Consensusangiotensin_on_gpOrthosteric Ligandat1_on_gp
37.50Consensusat1_on_gpOrthosteric Ligand7F6G-AT1-SAR1-AngII-Gq/β1/γ2
37.50Consensuscxcr3_on_gpOrthosteric Ligand8HNK-CXCR3-CXCL11-Gi1/β1/γ2 8HNL-CXCR3-PS372424-Gi1/β1/γ2
37.50Consensusgi_succinateOrthosteric Ligand8YKW-Succinate-Succinic acid-Gi1/β1/γ1 8YKX-Succinate-Maleic acid-Gi1/β1/γ1
37.50Consensusgq_angiotensinOrthosteric Ligand7F6G-AT1-SAR1-AngII-Gq/β1/γ2
37.50Consensusgs_vasop-oxyOrthosteric Ligand7DW9-V2-AVP-chim(NtGi1-Gs)/β1/γ2
37.50Consensusm2_onOrthosteric Ligand7T8X-M2-Acetylcholine-chim(NtGi1-Go)/β1/γ2
37.50Consensusm2_on_gpOrthosteric Ligand7T8X-M2-Acetylcholine-chim(NtGi1-Go)/β1/γ2
37.50Consensusprotein_onOrthosteric Ligandchemokine_on chemerin_on
37.50Consensussensory_offonOrthosteric Ligandsensory_off sensory_on
37.50Consensussensory_offon_gpOrthosteric Ligandsensory_on_gp sensory_on
37.50Consensussuccinate_onOrthosteric Ligand8YKW-Succinate-Succinic acid-Gi1/β1/γ1 8YKX-Succinate-Maleic acid-Gi1/β1/γ1
37.50Consensussuccinate_on_gpOrthosteric Ligand8YKW-Succinate-Succinic acid-Gi1/β1/γ1 8YKX-Succinate-Maleic acid-Gi1/β1/γ1
37.50Consensusv2_onOrthosteric Ligand7DW9-V2-AVP-chim(NtGi1-Gs)/β1/γ2
37.50Consensusv2_on_gpOrthosteric Ligand7DW9-V2-AVP-chim(NtGi1-Gs)/β1/γ2
37.50Consensusvasop-oxy_onOrthosteric Ligandv2_on
37.50Consensusvasop-oxy_on_gpOrthosteric Ligandv2_on_gp
37.04Consensusbk2_onOrthosteric Ligand7F6H-BK2-Bradykinin-Gq/β1/γ2 7F6I-BK2-Kallidin-Gq/β1/γ2
37.04Consensusbk2_on_gpOrthosteric Ligand7F6H-BK2-Bradykinin-Gq/β1/γ2 7F6I-BK2-Kallidin-Gq/β1/γ2
37.04Consensusbradykinin_onOrthosteric Ligandbk2_on
37.04Consensusbradykinin_on_gpOrthosteric Ligandbk2_on_gp
37.04Consensusgq_bradykininOrthosteric Ligand7F6H-BK2-Bradykinin-Gq/β1/γ2 7F6I-BK2-Kallidin-Gq/β1/γ2
36.84Single3UON3-quinuclidinyl-benzilate3UON-M2-3-quinuclidinyl-benzilate
36.84Single5ZHPPubChem 1348285895ZHP-M3-PubChem 134828589
36.84Single6E59L-7607356E59-NK1-L-760735
36.84Single6OIJIperoxo6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/β1/γ2
36.84Single7B6WCyclazosin7B6W-α1b-Cyclazosin
36.84Single7EW7SEW28717EW7-S1P1-SEW2871-Gi1/β1/γ2
36.84Single7TUYGSK682753A7TUY-GPR183-GSK682753A
36.84Single7WV9CP559407WV9-CB1-CP55940-ZCZ011-Gi2/β1/γ2
36.84Single7XAVLanreotide7XAV-SST2-Lanreotide-Gi1/β1/γ2
36.84Single7XTQR3997XTQ-GPBA-R399-Gs/β1/γ2
36.84Single7Y24Octreotide7Y24-SST2-Octreotide-Go/β1/γ2
36.84Single8ID6Oleic acid8ID6-FFA4-Oleic acid-Gi1/β1/γ2
36.84Single8JXWVUF68848JXW-H4-VUF6884-Gi1/β1/γ2
36.84Single8JXXClobenpropit8JXX-H4-Clobenpropit-Gi1/β1/γ2
36.84Single8WU1PubChem 1190256658WU1-CB1-PubChem 119025665-Arrestin2
36.84Single8X16Piclidenoson8X16-A3A-Piclidenoson-Gi1/β1/γ2
36.84Single8XIPPasireotide8XIP-SST1-Pasireotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
36.84Single8XZICMF-0198XZI-Apelin-CMF-019-Gi1/β1/γ2
36.84Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/β1/γ2
36.84Single9B65KCA9B65-CB1-KCA-Gi1/β1/γ2
36.84Consensusgi_cannabinoidOrthosteric Ligand8GUR-CB2-CP55,940-Gi1/β1/γ2 8GUS-CB2-HU-308-Gi1/β1/γ2 8GUT-CB2-LEI-102-Gi1/β1/γ2 8GUQ-CB2-Olorinab-Gi1/β1/γ2 6KPF-CB2-PubChem 145915889-Gi1/β1/γ2 6PT0-CB2-WIN 55212-2-Gi1/β1/γ2 6KPG-CB1-AM841-Gi1/β1/γ2
36.84Consensush4_on_gpOrthosteric Ligand8HN8-H4-Histamine-Gi1/β1/γ2 8HOC-H4-Imetit-Gi1/β1/γ2 8JXV-H4-Clozapine-Gi1/β1/γ2 8JXW-H4-VUF6884-Gi1/β1/γ2 8JXX-H4-Clobenpropit-Gi1/β1/γ2
36.84Consensusm1_on_gpOrthosteric Ligand6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/β1/γ2
36.84Consensusnpy_offOrthosteric Ligandnpy1_off npy2_off
36.36Single7F4ISHU91197F4I-MC1-SHU9119-chim(NtGi1-Gs)/β1/γ2
36.36Single7F8XNN90567F8X-CCKA-NN9056
36.36Single8G59TUG-8918G59-FFA4-TUG-891-chim(Gi1-CtGq)/β1/γ2
36.36Single8GHVAMG3158GHV-CB1-AMG315-Gi1/β1/γ2
36.36Consensuschemerin_on_gpOrthosteric Ligandcml1_on_gp
36.36Consensuscml1_onOrthosteric Ligand7YKD-CML1-Chemerin-9-Gi1/β1/γ2
36.36Consensusgi_chemerinOrthosteric Ligand7YKD-CML1-Chemerin-9-Gi1/β1/γ2
36.36Consensusgi_nucleotideOrthosteric Ligandgi_adenosine gi_p2y
36.36Consensuslpl_onOrthosteric Ligands1p_on lpa_on
36.36Consensuslpl_on_gpOrthosteric Ligands1p_on_gp lpa_on_gp
36.00Single7F6HBradykinin7F6H-BK2-Bradykinin-Gq/β1/γ2
36.00Single7X9CPancreatic Hormone7X9C-Y4-Pancreatic Hormone-Gi1/β1/γ2
36.00Single8XQEApelin-138XQE-Apelin-Apelin-13-Gi1/β1/γ2
36.00Consensuscml1_on_gpOrthosteric Ligand7YKD-CML1-Chemerin-9-Gi1/β1/γ2
35.71Single3RFMCaffeine3RFM-A2A-Caffeine
35.71Single6OY9All-trans-Retinal6OY9-Rhodopsin-All-trans-Retinal-Gt/β1/γ1
35.71Single7MTBAll-trans-Retinal7MTB-Rhodopsin-All-trans-Retinal-GRK1
35.71Single8A2OTheophylline8A2O-A2A-Theophylline-Na
35.71Single8WC5Tetramethylammonium Ion8WC5-TA1-Tetramethylammonium Ion-chim(NtGi1-Gs)/β1/γ2
35.71Consensusbb2_onOrthosteric Ligand7W40-BB2-Bombesin-chim(NtGi1L-Gq)/β1/γ2 7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/β1/γ2
35.71Consensusbb2_on_gpOrthosteric Ligand7W40-BB2-Bombesin-chim(NtGi1L-Gq)/β1/γ2 7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/β1/γ2
35.71Consensusbombesin_onOrthosteric Ligandbb2_on
35.71Consensusbombesin_on_gpOrthosteric Ligandbb2_on_gp
35.71Consensusgq_bombesinOrthosteric Ligand7W40-BB2-Bombesin-chim(NtGi1L-Gq)/β1/γ2 7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/β1/γ2
35.71Consensusopsins_onOrthosteric Ligandrhodopsin_on opsin1lw_on
35.71Consensussensory_onOrthosteric Ligandopsins_on
35.29Single3REYXAC3REY-A2A-XAC
35.29Single4ZUDOlmesartan4ZUD-AT1-Olmesartan
35.29Single5IU4ZM-2413855IU4-A2A-ZM-241385-Na
35.29Single5IU7Q274563465IU7-A2A-Q27456346-Na
35.29Single5IUBQ274563445IUB-A2A-Q27456344-Na
35.29Single5JTBZM-2413855JTB-A2A-ZM-241385
35.29Single5K2BZM-2413855K2B-A2A-ZM-241385-Na
35.29Single5K2CZM-2413855K2C-A2A-ZM-241385-Na
35.29Single5NLXZM-2413855NLX-A2A-ZM-241385-Na
35.29Single5NM4ZM-2413855NM4-A2A-ZM-241385-Na
35.29Single5TE3Octyl-Beta-D-Glucopyranoside5TE3-Rhodopsin-Octyl-β-D-Glucopyranoside
35.29Single6AQFZM-2413856AQF-A2A-ZM-241385
35.29Single6ME42-Iodomelatonin6ME4-MT1-2-Iodomelatonin
35.29Single6TP3Nemorexant6TP3-OX1-Nemorexant
35.29Single6ZDRHMS1413f126ZDR-A2A-HMS1413f12-Na
35.29Single6ZDVChromone 5d6ZDV-A2A-Chromone 5d-Na
35.29Single7AROLUF58337ARO-A2A-LUF5833-Na
35.29Single7BB6AVP7BB6-V2-AVP-Gs/β1/γ2
35.29Single7F61PF-036547467F61-H3-PF-03654746-Cholesterol
35.29Single7T32ZM-2413857T32-A2A-ZM-241385
35.29Single7VUGJNJ-635330547VUG-GPR139-JNJ-63533054-Gi1/β1/γ2
35.29Single8FCZ11-cis-Retinal8FCZ-Rhodopsin-11-cis-Retinal
35.29Single8GURCP55,9408GUR-CB2-CP55,940-Gi1/β1/γ2
35.29Single8HNMVUF112228HNM-CXCR3-VUF11222-Gi1/β1/γ2
35.29Single8IY9Niacin8IY9-HCA2-Niacin-Go/β1/γ2
35.29Single8JIMMMF8JIM-HCA2-MMF-Gi1/β1/γ2
35.29Single8K5CAcipimox8K5C-HCA2-Acipimox
35.29Single8K9LDamgo8K9L-μ-Damgo-VV9-Gi3/β1/γ1
35.29Single8PM2DMCH8PM2-TA7-DMCH-Gs/β1/γ2
35.29Single8RQQZM-2413858RQQ-A2A-ZM-241385-Na
35.29Single8RWCStilSwitch28RWC-A2A-StilSwitch2-Na
35.29Single8RWDStilSwitch38RWD-A2A-StilSwitch3-Na
35.29Single8RWIStilSwitch28RWI-A2A-StilSwitch2-Na
35.29Single8Y01Retinal8Y01-Opsin1MW-Retinal-Gi1/β1/γ2
35.29Single8Y53MK50468Y53-BB3-MK5046-chim(NtGi1-Gs-CtGq)/β1/γ2
35.29Single9EPP11,20-Ethanoretinal9EPP-Rhodopsin-11,20-Ethanoretinal-chim(Gi1-CtGq)/β1/γ2
35.29Consensus5ht2a_offOrthosteric Ligand6A94-5-HT2A-Zotepine 6A93-5-HT2A-Risperidone 7VOD-5-HT2A-Cariprazine 7WC8-5-HT2A-Lumateperone 8JT8-5-HT2A-(R)-IHCH-7179
35.29Consensusa2_offOrthosteric Liganda2a_off
35.29Consensusa2a_offOrthosteric Ligand3RFM-A2A-Caffeine 8C9W-A2A-Etrumadenant 3UZA-A2A-GTPL9236 8GNG-A2A-Istradefylline 8CU6-A2A-LJ-4517 7PX4-A2A-PSB-2113 7PYR-A2A-PSB-2115 8DU3-A2A-PubChem 105526064 8JWY-A2A-2-118 8PWN-A2A-Theophylline 5IU4-A2A-ZM-241385-Na 5OLZ-A2A-PubChem 135566609-Na 6GT3-A2A-Imaradenant-Na 5OLV-A2A-LUAA41063-Na 5N2R-A2A-PSB-36-Na 5IU7-A2A-Q27456346-Na 5OLH-A2A-Vipadenant-Na 5OLO-A2A-Tozadenant-Na 6ZDR-A2A-HMS1413f12-Na 8GNE-A2A-KW-6356-Na 8JWZ-A2A-AB928-Na 5IU8-A2A-Q27456347-Na 5IUB-A2A-Q27456344-Na 6ZDV-A2A-Chromone 5d-Na 5IUA-A2A-Q27456348-Na 8A2P-A2A-LUAA47070-Na
35.29Consensusat1_offOrthosteric Ligand4YAY-AT1-ZD-7155 4ZUD-AT1-Olmesartan
35.29Consensushca_onOrthosteric Ligandhca2_on
35.00Single4Z36ONO-30805734Z36-LPA1-ONO-3080573
35.00Single6OS0Angiotensinogen6OS0-AT1-Angiotensinogen
35.00Single7EO4BAF3127EO4-S1P1-BAF312-Gi1/β1/γ2
35.00Single7EPENAM5637EPE-mGlu2; mGlu2-NAM563
35.00Single7EW2Fingolimod7EW2-S1P3-Fingolimod-Gi1/β1/γ2
35.00Single7MTRADX551647MTR-mGlu2; mGlu2-Glutamate-ADX55164
35.00Single8ID9Eicosapentaenoic acid8ID9-FFA4-Eicosapentaenoic acid-Gi1/β1/γ2
35.00Single8JWY2-1188JWY-A2A-2-118
35.00Single8T3QDocosa-4,7,10,13,16,19-Hexaenoic acid8T3Q-FFA4-Docosa-4,7,10,13,16,19-Hexaenoic acid-chim(NtGi2L-Gs-CtGq)/β1/γ2
35.00Single8VHFMBX-29828VHF-GPR119-MBX-2982-Gs/β1/γ2
35.00Single9IZHLPA9IZH-LPA1-LPA-chim(NtGi2-G13)/β1/γ2
35.00Single9L3WRetinoic acid receptor responder protein 29L3W-CML1-Retinoic acid receptor responder protein 2-Gi1/β1/γ2
35.00Consensusc3a_onOrthosteric Ligand8HK2-C3aB-C3a anaphylatoxin-Gi1/β1/γ2 8IA8-C3aB-E7 peptide-Gi1/β1/γ2
35.00Consensuscannabinoid_onOrthosteric Ligandcb2_on cb1_on
35.00Consensuscannabinoid_on_gpOrthosteric Ligandcb2_on_gp cb1_on_gp
35.00Consensuscb1_onOrthosteric Ligand6KPG-CB1-AM841-Gi1/β1/γ2 8K8J-CB1-Fenofibrate-chim(Gs-CtGq)/β1/γ2
35.00Consensusccr8_onOrthosteric Ligand8KFX-CCR8-LMD-009-Gi1/β1/γ2 8KFY-CCR8-ZK-756326-Gi1/β1/γ2 8U1U-CCR8-CCL1-Gi1/β1/γ2
35.00Consensuslipid_offonOrthosteric Ligandlipid_off lipid_on
35.00Consensuslipid_offon_gpOrthosteric Ligandlipid_on_gp lipid_off
35.00Consensuslpa1_offOrthosteric Ligand4Z36-LPA1-ONO-3080573 4Z35-LPA1-ONO-9910539 4Z34-LPA1-ONO-9780307
35.00Consensuslpa_offOrthosteric Ligandlpa1_off
35.00Consensuslpl_offOrthosteric Ligands1p_off lpa_off
35.00Consensusm4_onOrthosteric Ligand7TRS-M4-Acetylcholine-Gi1/β1/γ2 7V6A-M4-PubChem 9864275-Gi1/β1/γ2 8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/β1/γ2 7TRK-M4-Iperoxo-Gi1/β1/γ2
35.00Consensusm4_on_gpOrthosteric Ligand7TRS-M4-Acetylcholine-Gi1/β1/γ2 7V6A-M4-PubChem 9864275-Gi1/β1/γ2 8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/β1/γ2 7TRK-M4-Iperoxo-Gi1/β1/γ2
35.00Consensuss1p1_onOrthosteric Ligand7VIE-S1P1-S1P-Gi1/β1/γ2 7VIF-S1P1-S-FTY720-P-Gi1/β1/γ2 7VIG-S1P1-CBP-307-Gi1/β1/γ2 7EVY-S1P1-Siponimod-Gi1/β1/γ2 7EVZ-S1P1-Cenerimod-Gi1/β1/γ2 7EW0-S1P1-Ozanimod-Gi1/β1/γ2 7EW7-S1P1-SEW2871-Gi1/β1/γ2
35.00Consensuss1p1_on_gpOrthosteric Ligand7VIE-S1P1-S1P-Gi1/β1/γ2 7VIF-S1P1-S-FTY720-P-Gi1/β1/γ2 7VIG-S1P1-CBP-307-Gi1/β1/γ2 7EVY-S1P1-Siponimod-Gi1/β1/γ2 7EVZ-S1P1-Cenerimod-Gi1/β1/γ2 7EW0-S1P1-Ozanimod-Gi1/β1/γ2 7EW7-S1P1-SEW2871-Gi1/β1/γ2
35.00Consensuss1p3_onOrthosteric Ligand7EW3-S1P3-S1P-Gi1/β1/γ2 7EW4-S1P3-CYM5541-Gi1/β1/γ2 7EW2-S1P3-Fingolimod-Gi1/β1/γ2
34.78Single5XJM(Sar1,Ile8)-Angiotensin II5XJM-AT2-(Sar1,Ile8)-Angiotensin II
34.78Single7EZKCholecystokinin-87EZK-CCKA-Cholecystokinin-8-chim(NtGi1-Gs)/β1/γ2
34.78Single8F7WDynorphin8F7W-κ-Dynorphin-Gi1/β1/γ2
34.78Single8JZZC5a-desArg8JZZ-C5a1-C5a-desArg-Go/β1/γ2
34.78Consensusgi_cckOrthosteric Ligand7EZH-CCKA-Cholecystokinin-8-Gi1/β1/γ2 7F8V-CCKB-Gastrin-17-Gi2/β1/γ2
34.78Consensusgq_class-aOrthosteric Ligandgq_peptide gq_amine gq_nucleotide
34.62Single8H0PNMB308H0P-BB1-NMB30-chim(NtGi1-Gs-CtGq)/β1/γ2
34.62Single8XVEBQ30208XVE-ETB-BQ3020-chim(Gs-CtGq)/β1/γ2
34.62Consensusgi_proteinOrthosteric Ligandgi_chemokine gi_chemerin
34.62Consensusnpy4_onOrthosteric Ligand7X9C-Y4-Pancreatic Hormone-Gi1/β1/γ2
34.62Consensusnpy4_on_gpOrthosteric Ligand7X9C-Y4-Pancreatic Hormone-Gi1/β1/γ2
34.62Consensusprotein_on_gpOrthosteric Ligandchemokine_on_gp chemerin_on_gp
33.33Single1HZX11-cis-Retinal1HZX-Rhodopsin-11-cis-Retinal
33.33Single3EMLZM-2413853EML-A2A-ZM-241385
33.33Single4EIYZM-2413854EIY-A2A-ZM-241385-Na
33.33Single4YAYZD-71554YAY-AT1-ZD-7155
33.33Single4Z35ONO-99105394Z35-LPA1-ONO-9910539
33.33Single5IU8Q274563475IU8-A2A-Q27456347-Na
33.33Single5K2AZM-2413855K2A-A2A-ZM-241385-Na
33.33Single5OLGZM-2413855OLG-A2A-ZM-241385-Na
33.33Single5UENDU1725UEN-A1-DU172
33.33Single5VRAZM-2413855VRA-A2A-ZM-241385-Na
33.33Single5ZKPForopafant (SR27417)5ZKP-PAF-Foropafant (SR27417)
33.33Single6DRXLisuride6DRX-5-HT2B-Lisuride
33.33Single6LPJZM-2413856LPJ-A2A-ZM-241385-Na
33.33Single6LPKZM-2413856LPK-A2A-ZM-241385-Na
33.33Single6S0LZM-2413856S0L-A2A-ZM-241385
33.33Single7DB6Ramelteon7DB6-MT1-Ramelteon-Gi1/β1/γ2
33.33Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
33.33Single7EVZCenerimod7EVZ-S1P1-Cenerimod-Gi1/β1/γ2
33.33Single7EW0Ozanimod7EW0-S1P1-Ozanimod-Gi1/β1/γ2
33.33Single7F23Dopamine7F23-D1-Dopamine-GDP-Gs/β1/γ2
33.33Single7F4FAfamelanotide7F4F-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2
33.33Single7M3JNPS-2143; PO47M3J-CaS-NPS-2143; PO4
33.33Single7MBXCholecystokinin-87MBX-CCKA-Cholecystokinin-8-Gs/β1/γ1
33.33Single7PYRPSB-21157PYR-A2A-PSB-2115
33.33Single7TD2LPA7TD2-LPA1-LPA-Gi1/β1/γ2
33.33Single7V3ZCP559407V3Z-CB1-CP55940
33.33Single7VH0Ramelteon7VH0-MT2-Ramelteon-Gi1/β1/γ1
33.33Single7VKTLTB47VKT-BLT1-LTB4-Gi1/β1/γ2
33.33Single7XATSomatostatin-147XAT-SST2-Somatostatin-14-Gi1/β1/γ2
33.33Single7XZ6APD6687XZ6-GPR119-APD668-Gs/β1/γ2
33.33Single7Y65C5a peptide7Y65-C5a1-C5a peptide-Gi1/β1/γ2
33.33Single7YK7DC5910537YK7-RXFP4-DC591053-Gi2/β1/γ2
33.33Single7YU8ONO-07405567YU8-LPA1-ONO-0740556-Gi1/β1/γ2
33.33Single8GUTLEI-1028GUT-CB2-LEI-102-Gi1/β1/γ2
33.33Single8I7VAcipimox8I7V-HCA2-Acipimox-Gi1/β1/γ2
33.33Single8ITFDMCHA8ITF-TA9-DMCHA-chim(NtGi1-Gs)/β1/γ2
33.33Single8IYSTUG-8918IYS-FFA4-TUG-891-GDP-chim(NtGi1L-Gq)/β1/γ2
33.33Single8J21Butyric acid8J21-FFA3-Butyric acid-Gi1/β1/γ2
33.33Single8J24Acetic acid8J24-FFA2-Acetic acid-Gi1/β1/γ2
33.33Single8J6PNiacin8J6P-HCA2-Niacin-Compound 9n-Gi1/β1/γ2
33.33Single8J6QBeta-Hydroxybutyrate8J6Q-HCA2-β-Hydroxybutyrate-Compound 9n-Gi1/β1/γ2
33.33Single8JHNMMF8JHN-HCA2-MMF-Go/β1/γ2
33.33Single8JIINiacin8JII-HCA2-Niacin-Compound 9n-Gi1/β1/γ2
33.33Single8JT8(R)-IHCH-71798JT8-5-HT2A-(R)-IHCH-7179
33.33Single8JXTHistamine8JXT-H4-Histamine-PO4-Gi1/β1/γ2
33.33Single8K5DGSK2560738K5D-HCA2-GSK256073
33.33Single8RLNLUF58348RLN-A2A-LUF5834
33.33Single8RW7StilSwitch18RW7-A2A-StilSwitch1-Na
33.33Single8RWXStilSwitch38RWX-A2A-StilSwitch3-Na
33.33Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/β1/γ2
33.33Single8WRZPubChem 1023367048WRZ-CB1-PubChem 102336704-Arrestin2
33.33Single8XGSMetastin8XGS-Kiss1-Metastin-chim(NtGi1-Gq)/β1/γ2
33.33Single8XGUTAK4488XGU-Kiss1-TAK448-Gi1/β1/γ2
33.33Single8XVJMacitentan8XVJ-ETA-Macitentan
33.33Single8XWPEndothelin-18XWP-ETB-Endothelin-1-Gi1/β1/γ2
33.33Single8YICSAR2477998YIC-S1P1-SAR247799-Gi1/β1/γ2
33.33Single8ZQEGPR15L(C11)8ZQE-GPR15-GPR15L(C11)-Gi1/β1/γ1
33.33Single9EAILosartan9EAI-AT1-Losartan-Nanobody AT209
33.33Single9IZFNKP9IZF-LPA1-NKP-Gi1/β1/γ2
33.33Single9K27PrRP319K27-PrRP-PrRP31-chim(NtGi1-Gq)/β1/γ2
33.33Consensusblt1_onOrthosteric Ligand7VKT-BLT1-LTB4-Gi1/β1/γ2
33.33Consensusblt1_on_gpOrthosteric Ligand7VKT-BLT1-LTB4-Gi1/β1/γ2
33.33Consensusblt_onOrthosteric Ligandblt1_on
33.33Consensusblt_on_gpOrthosteric Ligandblt1_on_gp
33.33Consensusc3a_on_gpOrthosteric Ligand8HK2-C3aB-C3a anaphylatoxin-Gi1/β1/γ2 8IA8-C3aB-E7 peptide-Gi1/β1/γ2
33.33Consensuscck_offOrthosteric Ligandccka_off
33.33Consensuscck_onOrthosteric Ligandccka_on cckb_on
33.33Consensuscck_on_gpOrthosteric Ligandccka_on_gp cckb_on_gp
33.33Consensusccka_offOrthosteric Ligand7F8Y-CCKA-Devazepide 7F8U-CCKA-Lintitript
33.33Consensusffa3_onOrthosteric Ligand8J21-FFA3-Butyric acid-Gi1/β1/γ2
33.33Consensusffa3_on_gpOrthosteric Ligand8J21-FFA3-Butyric acid-Gi1/β1/γ2
33.33Consensusgi_hcaOrthosteric Ligand8J6R-HCA2-MK6892-Gi1/β1/γ2 8JIM-HCA2-MMF-Gi1/β1/γ2 8IHI-HCA2-Acifran-Gi1/β1/γ2 8IHH-HCA2-LUF6283-Gi1/β1/γ2 8I7V-HCA2-Acipimox-Gi1/β1/γ2 8I7W-HCA2-GSK256073-Gi1/β1/γ2
33.33Consensusgi_histamineOrthosteric Ligand8JXX-H4-Clobenpropit-Gi1/β1/γ2 8JXV-H4-Clozapine-Gi1/β1/γ2 8YUU-H3-Histamine-Gi1/β1/γ1 8HN8-H4-Histamine-Gi1/β1/γ2 8HOC-H4-Imetit-Gi1/β1/γ2 8JXW-H4-VUF6884-Gi1/β1/γ2
33.33Consensusgi_leukotrieneOrthosteric Ligand7VKT-BLT1-LTB4-Gi1/β1/γ2
33.33Consensusgs_cckOrthosteric Ligand7MBX-CCKA-Cholecystokinin-8-Gs/β1/γ1
33.33Consensusgs_peptideOrthosteric Ligandgs_cck gs_melanocortin gs_vasop-oxy
33.33Consensushca2_onOrthosteric Ligand8J6R-HCA2-MK6892-Gi1/β1/γ2 8JIM-HCA2-MMF-Gi1/β1/γ2 8I7V-HCA2-Acipimox-Gi1/β1/γ2 8I7W-HCA2-GSK256073-Gi1/β1/γ2 8IHH-HCA2-LUF6283-Gi1/β1/γ2 8IHI-HCA2-Acifran-Gi1/β1/γ2
33.33Consensushca2_on_gpOrthosteric Ligand8J6R-HCA2-MK6892-Gi1/β1/γ2 8IHI-HCA2-Acifran-Gi1/β1/γ2 8IHH-HCA2-LUF6283-Gi1/β1/γ2 8I7V-HCA2-Acipimox-Gi1/β1/γ2 8JIM-HCA2-MMF-Gi1/β1/γ2 8I7W-HCA2-GSK256073-Gi1/β1/γ2
33.33Consensushca_on_gpOrthosteric Ligandhca2_on_gp
33.33Consensusleukotriene_onOrthosteric Ligandblt_on
33.33Consensusleukotriene_on_gpOrthosteric Ligandblt_on_gp
33.33Consensusnucleotide_offonOrthosteric Ligandnucleotide_off nucleotide_on
33.33Consensusnucleotide_offon_gpOrthosteric Ligandnucleotide_on_gp nucleotide_off
33.33Consensusopsins_on_gpOrthosteric Ligandrhodopsin_on_gp opsin1lw_on_gp
33.33Consensusprostanoid_offOrthosteric Ligandep_off dp_off
33.33Consensusrhodopsin_onOrthosteric Ligand6OYA-Rhodopsin-All-trans-Retinal-Gt/β1/γ1
33.33Consensussensory_on_gpOrthosteric Ligandopsins_on_gp
32.14Single6IGLIRL16206IGL-ETB-IRL1620
32.14Single7VGXNeuropeptide-Y7VGX-Y1-Neuropeptide-Y-Gi1/β1/γ2
32.14Single8WWNMCH8WWN-MCH1-MCH-Gi1/β1/γ2
32.00Single6JODAngiotensin II6JOD-AT2-Angiotensin II
32.00Single7KH0AVP7KH0-V2-AVP-chim(NtGi1-Gs)/β1/γ2
32.00Single8X8LCortistatin8X8L-SST5-Cortistatin-chim(NtGi1-Gs-CtGi1)/β1/γ2
32.00Consensusapelin_onOrthosteric Ligand8XZH-Apelin-MM07-Gi1/β1/γ2 7W0M-Apelin-PubChem 122701908-Gi1/β1/γ2 8XZJ-Apelin-WN353-Gi1/β1/γ2 8XZF-Apelin-WN561-Gi1/β1/γ2 8XZG-Apelin-Apelin-13-Gi1/β1/γ2
32.00Consensusapelin_on_gpOrthosteric Ligand8XZH-Apelin-MM07-Gi1/β1/γ2 7W0M-Apelin-PubChem 122701908-Gi1/β1/γ2 8XZJ-Apelin-WN353-Gi1/β1/γ2 8XZF-Apelin-WN561-Gi1/β1/γ2 8XZG-Apelin-Apelin-13-Gi1/β1/γ2
32.00Consensusfpr2-alx_on_gpOrthosteric Ligand7WVX-FPR2-ALX-Humanin-Gi2/β1/γ2 7T6U-FPR2-ALX-CGEN-855A-Gi1/β1/γ2 7T6V-FPR2-ALX-fMLFII-Gi1/β1/γ2 7WVY-FPR2-ALX-Amyloid-β42-Gi2/β1/γ2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/β1/γ2 6OMM-FPR2-ALX-WKYMVX-Gi1/β1/γ2
31.82Single6W2YPubChem 237279706W2Y-GABAB1; GABAB1-PubChem 5311042-PubChem 23727970
31.82Single7Y1FDynorphin7Y1F-κ-Dynorphin-Gi1/β1/γ2
31.82Single7YAEOctreotide7YAE-SST2-Octreotide-Gi1/β1/γ2
31.82Single8H4IDoconexent8H4I-FFA4-Doconexent-chim(NtGi1-Gs)/β1/γ2
31.82Single8QJ2pN1628QJ2-MC4-pN162-Gs
31.82Single9ERXD9-THC analog9ERX-CB1-D9-THC analog-Gi1/β1/γ2
31.82Consensuscxcr_on_gpOrthosteric Ligandcxcr3_on_gp cxcr4_on_gp cxcr1_on_gp cxcr2_on_gp
31.58Single5IUAQ274563485IUA-A2A-Q27456348-Na
31.58Single5N2RPSB-365N2R-A2A-PSB-36-Na
31.58Single5N2SPSB365N2S-A1-PSB36
31.58Single5ZBQUR-MK-2995ZBQ-Y1-UR-MK-299
31.58Single6D26Fevipiprant6D26-DP2-Fevipiprant
31.58Single6KPCPubChem 1459158896KPC-CB2-PubChem 145915889
31.58Single6LPLZM-2413856LPL-A2A-ZM-241385-Na
31.58Single6S0QZM-2413856S0Q-A2A-ZM-241385
31.58Single6W2XPubChem 237279706W2X-GABAB1, GABAB2-PubChem 5311042-PubChem 23727970
31.58Single6WQAZM-2413856WQA-A2A-ZM-241385-Na
31.58Single7BB7AVP7BB7-V2-AVP-Gs/β1/γ2
31.58Single7EO2FTY720-P7EO2-S1P1-FTY720-P-Gi1/β1/γ2
31.58Single7EPFNAM5977EPF-mGlu2; mGlu2-NAM597
31.58Single7M3JNPS-2143; PO47M3J-CaS-NPS-2143; PO4
31.58Single7RM5ZM-2413857RM5-A2A-ZM-241385-Na
31.58Single7SINNPS-21437SIN-CaS-NPS-2143
31.58Single7SINNPS-21437SIN-CaS-NPS-2143
31.58Single7VFXfMLF7VFX-FPR1-ALX-fMLF-Gi1/β1/γ2
31.58Single7VOEAripiprazole7VOE-5-HT2A-Aripiprazole
31.58Single7W41PD1762527W41-BB2-PD176252
31.58Single7YU6ONO-07405567YU6-LPA1-ONO-0740556-Gi1/β1/γ2
31.58Single8FYNZM-2413858FYN-A2A-ZM-241385-Na
31.58Single8GNEKW-63568GNE-A2A-KW-6356-Na
31.58Single8I7WGSK2560738I7W-HCA2-GSK256073-Gi1/β1/γ2
31.58Single8ID4Linoleic acid8ID4-FFA4-Linoleic acid-Gi1/β1/γ2
31.58Single8K8JFenofibrate8K8J-CB1-Fenofibrate-chim(Gs-CtGq)/β1/γ2
31.58Single8QOTNanobody-E8QOT-μ-Nanobody-E
31.58Single8SZGCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-chim(NtGi1-Gq)/β1/γ2
31.58Single8UUJFCH-22964138UUJ-HCA2-FCH-2296413-Gi1/β1/γ2
31.58Single8YNSSNAP-948478YNS-MCH1-SNAP-94847
31.58Single8ZPTPrRP208ZPT-PrRP-PrRP20-chim(NtGi1-Gs-CtGq)/β1/γ2
31.58Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/β1/γ2
31.58Single9IYBProstaglandin9IYB-DP2-Prostaglandin-A1D5Q-Gi1/β1/γ2
31.58Consensusa1_offOrthosteric Ligand5UEN-A1-DU172 5N2S-A1-PSB36
31.58Consensusbb2_offOrthosteric Ligand7W41-BB2-PD176252
31.58Consensusbombesin_offOrthosteric Ligandbb2_off
31.58Consensusdp2_offOrthosteric Ligand6D26-DP2-Fevipiprant
31.58Consensusdp_offOrthosteric Liganddp2_off
31.58Consensusfpr1-alx_onOrthosteric Ligand7VFX-FPR1-ALX-fMLF-Gi1/β1/γ2
31.58Consensusfpr1-alx_on_gpOrthosteric Ligand7VFX-FPR1-ALX-fMLF-Gi1/β1/γ2
31.58Consensusgq_muscarinicOrthosteric Ligand6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/β1/γ2
31.58Consensuslipid_onOrthosteric Ligandcannabinoid_on ffa_on lpl_on prostanoid_on leukotriene_on
31.58Consensuslipid_on_gpOrthosteric Ligandcannabinoid_on_gp ffa_on_gp lpl_on_gp prostanoid_on_gp leukotriene_on_gp
31.58Consensusm1_onOrthosteric Ligand6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/β1/γ2
31.25Single1U1911-cis-Retinal1U19-Rhodopsin-11-cis-Retinal
31.25Single2G87All-trans-Retinal2G87-Rhodopsin-All-trans-Retinal
31.25Single2I3511-cis-Retinal2I35-Rhodopsin-11-cis-Retinal
31.25Single6I9K9-cis-Retinal6I9K-Rhodopsin-9-cis-Retinal
31.25Single6QNOAll-trans-Retinal6QNO-Rhodopsin-All-trans-Retinal-Gi1/β1/γ1
31.25Single6TP4ACT-4622066TP4-OX1-ACT-462206
31.25Single6TQ4PubChem 160468446TQ4-OX1-PubChem 16046844-Na
31.25Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
31.25Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
31.25Single7YFCHistamine7YFC-H4-Histamine-chim(NtGi1-Gs-CtGq)/β1/γ2
31.25Single7YFDImetit7YFD-H4-Imetit-chim(NtGi1-Gs-CtGq)/β1/γ2
31.25Single8A2PLUAA470708A2P-A2A-LUAA47070-Na
31.25Single8HN8Histamine8HN8-H4-Histamine-Gi1/β1/γ2
31.25Single8JPNCis-Epoxysuccinic acid8JPN-Succinate-Cis-Epoxysuccinic acid-Gi1/β1/γ1
31.25Single8RWHStilSwitch28RWH-A2A-StilSwitch2-Na
31.25Single8WP1Cis-Epoxysuccinic acid8WP1-Succinate-Cis-Epoxysuccinic acid-Gi1/β1/γ2
31.25Single8Y0NVUF114188Y0N-CXCR3-VUF11418-Go1/β1/γ2
31.25Single8YKWSuccinic acid8YKW-Succinate-Succinic acid-Gi1/β1/γ1
31.25Single9EPQ11,20-Ethanoretinal9EPQ-Rhodopsin-11,20-Ethanoretinal-chim(Gi1-CtGq)/β1/γ2
31.25Single9IQTNiacin9IQT-HCA2-Niacin-Gi1/β1/γ2
31.25Consensush4_onOrthosteric Ligand8HN8-H4-Histamine-Gi1/β1/γ2 8HOC-H4-Imetit-Gi1/β1/γ2 8JXV-H4-Clozapine-Gi1/β1/γ2 8JXW-H4-VUF6884-Gi1/β1/γ2 8JXX-H4-Clobenpropit-Gi1/β1/γ2
31.03Single5GLHEndothelin-15GLH-ETB-Endothelin-1
31.03Single6IGKEndothelin-36IGK-ETB-Endothelin-3
31.03Consensusgi_endothelinOrthosteric Ligand8IY5-ETB-Endothelin-1-Gi1/β1/γ2 8HBD-ETB-IRL1620-Gi1/β1/γ2
31.03Consensusgi_npyOrthosteric Ligand8K6M-Y1-Neuropeptide-Y-Gi2/β1/γ1 7X9C-Y4-Pancreatic Hormone-Gi1/β1/γ2 7YOO-Y2-Neuropeptide-Y-Gi1/β1/γ2
31.03Consensusnpy_onOrthosteric Ligandnpy1_on npy2_on npy4_on
31.03Consensusnpy_on_gpOrthosteric Ligandnpy1_on_gp npy2_on_gp npy4_on_gp
30.77Single5MZPCaffeine5MZP-A2A-Caffeine-Na
30.77Single7F6IKallidin7F6I-BK2-Kallidin-Gq/β1/γ2
30.77Single7X9BNeuropeptide-Y7X9B-Y2-Neuropeptide-Y-Gi1/β1/γ2
30.77Single7XV3Lysophosphatidylserine7XV3-GPR174-Lysophosphatidylserine-chim(NtGi1-Gs)/β1/γ2
30.77Single7Y64C5a anaphylatoxin7Y64-C5a1-C5a anaphylatoxin-Gi1/β1/γ2
30.77Single8GEJConstrained Epinephrine8GEJ-β2-Constrained Epinephrine-Gs/β1/γ2
30.77Single8IODPG-9018IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/β1/γ2
30.77Single8WWKMCH8WWK-MCH1-MCH-Gi1/β1/γ2
30.77Single8XVHEndothelin-18XVH-ETB-Endothelin-1-chim(Gs-CtGq)/β1/γ2
30.77Single8ZRTET-18ZRT-ETB-ET-1
30.77Consensusgi_apelinOrthosteric Ligand8XZH-Apelin-MM07-Gi1/β1/γ2 7W0M-Apelin-PubChem 122701908-Gi1/β1/γ2 8XZJ-Apelin-WN353-Gi1/β1/γ2 8XZF-Apelin-WN561-Gi1/β1/γ2 8XZG-Apelin-Apelin-13-Gi1/β1/γ2
30.77Consensusmc1_onOrthosteric Ligand7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2 7F4D-MC1-α-MSH-chim(NtGi1-Gs)/β1/γ2 7F4I-MC1-SHU9119-chim(NtGi1-Gs)/β1/γ2
30.77Consensusmc1_on_gpOrthosteric Ligand7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2 7F4D-MC1-α-MSH-chim(NtGi1-Gs)/β1/γ2 7F4I-MC1-SHU9119-chim(NtGi1-Gs)/β1/γ2
30.43Single7T6UCGEN-855A7T6U-FPR2-ALX-CGEN-855A-Gi1/β1/γ2
30.43Single7WICSomatostatin-147WIC-SST2-Somatostatin-14-Gi1/β1/γ2
30.43Single8F7XNociceptin8F7X-NOP-Nociceptin-Gi1/β1/γ2
30.43Single8J6RMK68928J6R-HCA2-MK6892-Gi1/β1/γ2
30.43Single8K3ZCXCL128K3Z-CXCR4-CXCL12-Gi1/β1/γ1
30.43Single8WKYPG-9348WKY-MC4-PG-934
30.43Single9BKJCholecystokinin-89BKJ-CCKA-Cholecystokinin-8-chim(NtGi1-Gs-CtGq)/β1/γ2
30.43Consensusnop_onOrthosteric Ligand8F7X-NOP-Nociceptin-Gi1/β1/γ2
30.43Consensusnop_on_gpOrthosteric Ligand8F7X-NOP-Nociceptin-Gi1/β1/γ2
30.43Consensussst5_onOrthosteric Ligand8X8L-SST5-Cortistatin-chim(NtGi1-Gs-CtGi1)/β1/γ2 8X8N-SST5-Octreotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
30.00Single4Z34ONO-97803074Z34-LPA1-ONO-9780307
30.00Single5XR8AM8415XR8-CB1-AM841
30.00Single5XRAAM115425XRA-CB1-AM11542
30.00Single6N4BMDMB-Fubinaca6N4B-CB1-MDMB-Fubinaca-Gi1/β1/γ2
30.00Single7EW3S1P7EW3-S1P3-S1P-Gi1/β1/γ2
30.00Single7EW4CYM55417EW4-S1P3-CYM5541-Gi1/β1/γ2
30.00Single7F58THIQ7F58-MC4-THIQ-Gs/β1/γ2
30.00Single7FEECP559407FEE-CB1-CP55940-ZCZ011
30.00Single7M8W15r-Methyl-Prostaglandin D27M8W-DP2-15r-Methyl-Prostaglandin D2-Na
30.00Single7PX4PSB-21137PX4-A2A-PSB-2113
30.00Single7TD1LPA7TD1-LPA1-LPA-Gi1/β1/γ2
30.00Single7WVXHumanin7WVX-FPR2-ALX-Humanin-Gi2/β1/γ2
30.00Single7YU7ONO-07405567YU7-LPA1-ONO-0740556-Gi1/β1/γ2
30.00Single8I9LC3a anaphylatoxin8I9L-C3aB-C3a anaphylatoxin-Go/β1/γ2
30.00Single8IHBGSK2560738IHB-HCA2-GSK256073-Gi1/β1/γ2
30.00Single8IHHLUF62838IHH-HCA2-LUF6283-Gi1/β1/γ2
30.00Single8JSRAnamorelin8JSR-Ghrelin-Anamorelin-chim(NtGi1-Gs-CtGq)/β1/γ2
30.00Single8JZPC5A anaphylatoxin8JZP-C5a1-C5A anaphylatoxin-Go/β1/γ2
30.00Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/β1/γ2
30.00Single9IZGNKP9IZG-LPA1-NKP-chim(NtGi1-Gs-CtGq)/β1/γ2
30.00Consensuscyslt1_offOrthosteric Ligand6RZ5-CysLT1-Zafirlukast-Na 6RZ4-CysLT1-Pranlukast-Na
30.00Consensusetb_on_gpOrthosteric Ligand8IY5-ETB-Endothelin-1-Gi1/β1/γ2 8HBD-ETB-IRL1620-Gi1/β1/γ2
30.00Consensusnpy1_offOrthosteric Ligand5ZBH-Y1-BMS-193885 5ZBQ-Y1-UR-MK-299
30.00Consensusprotein_offOrthosteric Ligandchemokine_off grh_off
29.63Single7RGPTirzepatide7RGP-GLP-1-Tirzepatide-chim(NtGi1-Gs)/β1/γ2
29.63Single8XQFApelin-138XQF-Apelin-Apelin-13-Gi1/β1/γ2
29.63Consensusgi_compl-peptOrthosteric Ligand8HK5-C5a1-Complement C5-Gi1/β1/γ2 8IA8-C3aB-E7 peptide-Gi1/β1/γ2 7Y66-C5a1-BM213-Gi1/β1/γ2 7Y67-C5a1-C089 peptide-Gi1/β1/γ2 8HK2-C3aB-C3a anaphylatoxin-Gi1/β1/γ2 7Y64-C5a1-C5a anaphylatoxin-Gi1/β1/γ2
29.41Single1GZM11-cis-Retinal1GZM-Rhodopsin-11-cis-Retinal
29.41Single3C9L11-cis-Retinal3C9L-Rhodopsin-11-cis-Retinal
29.41Single3PWHZM-2413853PWH-A2A-ZM-241385
29.41Single3V2WPubChem 518926453V2W-S1P1-PubChem 51892645
29.41Single3VG9ZM-2413853VG9-A2A-ZM-241385-Antibody
29.41Single6DS0Ly2660976DS0-5-HT2B-Ly266097
29.41Single6OYAAll-trans-Retinal6OYA-Rhodopsin-All-trans-Retinal-Gt/β1/γ1
29.41Single7BR3Elagolix7BR3-GnRH1-Elagolix
29.41Single7M3ECa; Ca; Tryptophan; NPS-21437M3E-CaS-Ca; Ca; Tryptophan; NPS-2143
29.41Single7M3ECa; Ca; Tryptophan; NPS-21437M3E-CaS-Ca; Ca; Tryptophan; NPS-2143
29.41Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
29.41Single7TUZ7-alpha,25-dihydroxycholesterol7TUZ-GPR183-7-α,25-dihydroxycholesterol-Gi1/β1/γ2
29.41Single7VIHCBP-3077VIH-S1P1-CBP-307-Gi1/β1/γ2
29.41Single8IJBAcipimox8IJB-HCA2-Acipimox-Gi1/β1/γ2
29.41Single8J20Valeric acid8J20-FFA3-Valeric acid-AR420626-Gi1/β1/γ2
29.41Single8J6LNiacin8J6L-HCA2-Niacin-Gi1/β1/γ2
29.41Single8JPPSuccinic acid8JPP-Succinate-Succinic acid-chim(Gs-CtGq)/β1/γ1
29.41Single8RVWStilSwitch38RVW-A2A-StilSwitch3-Na
29.41Single8RW4AzoSwitch28RW4-A2A-AzoSwitch2-Na
29.41Single8RWEStilSwitch48RWE-A2A-StilSwitch4-Na
29.41Single8T3SButyric acid8T3S-FFA2-Butyric acid-chim(NtGi2L-Gs-CtGq)/β1/γ2
29.41Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
29.41Single9BQJRO769BQJ-μ-RO76-Gi1/β1/γ2
29.41Single9FUPIstradefylline9FUP-A2A-Istradefylline-Na
29.41Consensusgnrh1_offOrthosteric Ligand7BR3-GnRH1-Elagolix
29.41Consensusrhodopsin_offOrthosteric Ligand1U19-Rhodopsin-11-cis-Retinal 2PED-Rhodopsin-9-cis-Retinal 5TE5-Rhodopsin-20-Methanoretinal
29.41Consensusrhodopsin_on_gpOrthosteric Ligand6OYA-Rhodopsin-All-trans-Retinal-Gt/β1/γ1
29.41Consensuss1p1_offOrthosteric Ligand3V2W-S1P1-PubChem 51892645
29.17Single7CUMPhospholipid7CUM-GABAB1, GABAB2-CGP54626-Phospholipid
29.17Single7RKMFractalkine7RKM-US28-Fractalkine-Gi1/β1/γ2
29.17Single7W0NElabela7W0N-Apelin-Elabela-Gi1/β1/γ2
29.17Single7WJ5Somatostatin-147WJ5-SST2-Somatostatin-14-Gi1/β1/γ2
29.17Single8F7QBeta-Endorphin8F7Q-μ-β-Endorphin-Gi1/β1/γ2
29.17Single8Z7JAgonistic antibody8Z7J-Apelin-Agonistic antibody-Gi1/β1/γ2
29.17Consensuscckb_onOrthosteric Ligand8IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/β1/γ2 7XOW-CCKB-Gastrin-chim(NtGi1-Gq)/β1/γ2 7F8V-CCKB-Gastrin-17-Gi2/β1/γ2
29.17Consensusccr8_on_gpOrthosteric Ligand8KFX-CCR8-LMD-009-Gi1/β1/γ2 8KFY-CCR8-ZK-756326-Gi1/β1/γ2 8U1U-CCR8-CCL1-Gi1/β1/γ2
29.17Consensuscompl-peptide_onOrthosteric Ligandc5a1_on c3a_on
29.17Consensusformylpeptide_on_gpOrthosteric Ligandfpr2-alx_on_gp fpr1-alx_on_gp
29.17Consensusghrelin_onOrthosteric Ligand7NA7-Ghrelin-Ghrelin-27-Gi1/β1/γ2 7F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/β1/γ2 7NA8-Ghrelin-PubChem 178024-Gi1/β1/γ2
29.17Consensusghrelin_on_gpOrthosteric Ligand7NA7-Ghrelin-Ghrelin-27-Gi1/β1/γ2 7F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/β1/γ2 7NA8-Ghrelin-PubChem 178024-Gi1/β1/γ2
29.03Single6LRYSarafotoxin-B6LRY-ETB-Sarafotoxin-B
28.57Single3PXOAll-trans-Retinal3PXO-Rhodopsin-All-trans-Retinal
28.57Single4OR2FITM4OR2-mGlu1; mGlu1-FITM
28.57Single5DYSAll-trans-Retinal5DYS-Rhodopsin-All-trans-Retinal
28.57Single5MZJTheophylline5MZJ-A2A-Theophylline-Na
28.57Single6KQICP559406KQI-CB1-CP55940-Org27569
28.57Single6XBLCholesterol6XBL-SMO-SAG-Cholesterol-Gi1/β1/γ2
28.57Single7EIBDes-Arg10-Kallidin7EIB-BK1-Des-Arg10-Kallidin-chim(NtGi1-Gs-CtGq)/β1/γ2
28.57Single7EVYSiponimod7EVY-S1P1-Siponimod-Gi1/β1/γ2
28.57Single7F53Alpha-MSH7F53-MC4-α-MSH-Gs/β1/γ2
28.57Single7K15MKD0467K15-BLT1-MKD046-Na
28.57Single7L1UOrexin7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/β1/γ2
28.57Single7WCMMBX-29827WCM-GPR119-MBX-2982-Gs/β1/γ2
28.57Single7Y66BM2137Y66-C5a1-BM213-Gi1/β1/γ2
28.57Single7YOONeuropeptide-Y7YOO-Y2-Neuropeptide-Y-Gi1/β1/γ2
28.57Single8HK2C3a anaphylatoxin8HK2-C3aB-C3a anaphylatoxin-Gi1/β1/γ2
28.57Single8IYWGSK2560738IYW-HCA2-GSK256073-Go/β1/γ2
28.57Single8J6DEP1418J6D-C3aB-EP141-Go/β1/γ2
28.57Single8JD3HZR; PEF8JD3-mGlu2; mGlu3-Glutamate-HZR; PEF-Gi1/β1/γ2
28.57Single8PWNTheophylline8PWN-A2A-Theophylline
28.57Single8WWLMCH8WWL-MCH1-MCH-Gi1/β1/γ2
28.57Single8X8NOctreotide8X8N-SST5-Octreotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
28.57Single8ZJGChemerin8ZJG-CML1-Chemerin-Gi1/β1/γ2
28.57Consensuscannabinoid_offOrthosteric Ligandcb2_off cb1_off
28.57Consensusleukotriene_offOrthosteric Ligandblt_off cyslt_off
28.57Consensusnpy2_onOrthosteric Ligand7YOO-Y2-Neuropeptide-Y-Gi1/β1/γ2
28.57Consensusnpy2_on_gpOrthosteric Ligand7YOO-Y2-Neuropeptide-Y-Gi1/β1/γ2
28.12Single7X9ANeuropeptide-Y7X9A-Y1-Neuropeptide-Y-Gi1/β1/γ2
28.00Single6W25SHU91196W25-MC4-SHU9119-Ca
28.00Single7XOUCholecystokinin-87XOU-CCKA-Cholecystokinin-8-Gs/β1/γ2
28.00Single8K6NPro-neuropeptide-Y8K6N-Y2-Pro-neuropeptide-Y-Gi2/β1/γ1
28.00Single8WKZSBL-MC-318WKZ-MC4-SBL-MC-31
28.00Single8XZGApelin-138XZG-Apelin-Apelin-13-Gi1/β1/γ2
28.00Single8XZHMM078XZH-Apelin-MM07-Gi1/β1/γ2
28.00Consensusc5a1_onOrthosteric Ligand8HK5-C5a1-Complement C5-Gi1/β1/γ2 7Y66-C5a1-BM213-Gi1/β1/γ2 7Y67-C5a1-C089 peptide-Gi1/β1/γ2 7Y64-C5a1-C5a anaphylatoxin-Gi1/β1/γ2
28.00Consensuscckb_on_gpOrthosteric Ligand8IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/β1/γ2 7XOW-CCKB-Gastrin-chim(NtGi1-Gq)/β1/γ2 7F8V-CCKB-Gastrin-17-Gi2/β1/γ2
28.00Consensuscompl-peptide_on_gpOrthosteric Ligandc5a1_on_gp c3a_on_gp
28.00Consensuscxcr4_on_gpOrthosteric Ligand8K3Z-CXCR4-CXCL12-Gi1/β1/γ1
28.00Consensusfpr2-alx_onOrthosteric Ligand7WVX-FPR2-ALX-Humanin-Gi2/β1/γ2 7T6U-FPR2-ALX-CGEN-855A-Gi1/β1/γ2 7T6V-FPR2-ALX-fMLFII-Gi1/β1/γ2 7WVY-FPR2-ALX-Amyloid-β42-Gi2/β1/γ2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/β1/γ2 6OMM-FPR2-ALX-WKYMVX-Gi1/β1/γ2
27.78Single1F8811-cis-Retinal1F88-Rhodopsin-11-cis-Retinal
27.78Single3OAX11-cis-Retinal3OAX-Rhodopsin-11-cis-Retinal
27.78Single3V2YPubChem 518926453V2Y-S1P1-PubChem 51892645
27.78Single5UVIZM-2413855UVI-A2A-ZM-241385
27.78Single6MH8ZM-2413856MH8-A2A-ZM-241385
27.78Single6PT0WIN 55212-26PT0-CB2-WIN 55212-2-Gi1/β1/γ2
27.78Single6ZG9GSK10347026ZG9-M1-GSK1034702
27.78Single7XOVSR1461317XOV-CCKA-SR146131-Gs/β1/γ2
27.78Single7YK6PubChem 1383196747YK6-RXFP4-PubChem 138319674-Gi2/β1/γ2
27.78Single7ZBC11-cis-Retinal7ZBC-Rhodopsin-11-cis-Retinal
27.78Single7ZBE11-cis-Retinal7ZBE-Rhodopsin-11-cis-Retinal
27.78Single8GUQOlorinab8GUQ-CB2-Olorinab-Gi1/β1/γ2
27.78Single8IHKAcifran8IHK-HCA3-Acifran
27.78Single8JEI3-nitro-4-(propylamino)benzoic acid8JEI-HCAR3-3-nitro-4-(propylamino)benzoic acid-Gi1/β1/γ2
27.78Single8JERAcipimox8JER-HCA2-Acipimox-Go/β1/γ2
27.78Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
27.78Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/β1/γ2
27.78Single8Y62C16:0 Ceramide8Y62-FPR2-ALX-C16:0 Ceramide-Gi1/β1/γ2
27.78Single8YKVPubChem 1375531688YKV-Succinate-PubChem 137553168-Gi1/β1/γ2
27.78Single8ZPMAMD0708ZPM-CXCR4-AMD070-Cholesterol
27.78Single8ZPNAMD31008ZPN-CXCR4-AMD3100-Cholesterol
27.78Single9ASBCa; Ca; Cyclomethyltryptophan; 9IG; PO49ASB-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
27.78Single9ASBCa; Ca; Cyclomethyltryptophan; 9IG; PO49ASB-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
27.78Single9AVGCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVG-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs)/β1/γ2
27.78Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
27.78Single9K1DButanoic acid9K1D-FFA2-Butanoic acid-Cholesterol-Gi1/β1/γ2
27.78Consensusghrelin_offOrthosteric Ligand6KO5-Ghrelin-PubChem 57400002 7F83-Ghrelin-PF-05190457
27.78Consensusgrh_offOrthosteric Ligandgnrh1_off
27.78Consensusnucleotide_offOrthosteric Ligandadenosine_off p2y_off
27.78Consensusopsins_offOrthosteric Ligandrhodopsin_off
27.78Consensussensory_offOrthosteric Ligandopsins_off
27.59Single7TS0Urocortin7TS0-CRF2-Urocortin-chim(NtGi1L-Go)/β1/γ2
27.59Single8IY5Endothelin-18IY5-ETB-Endothelin-1-Gi1/β1/γ2
27.59Single8Y52BA18Y52-BB3-BA1-chim(NtGi1-Gs-CtGq)/β1/γ2
27.59Consensusendothelin_onOrthosteric Ligandetb_on eta_on
27.59Consensusetb_onOrthosteric Ligand8IY5-ETB-Endothelin-1-Gi1/β1/γ2 8HBD-ETB-IRL1620-Gi1/β1/γ2
27.27Single4OR2FITM4OR2-mGlu1; mGlu1-FITM
27.27Single6K1QIRL25006K1Q-ETB-IRL2500
27.27Single7EZHCholecystokinin-87EZH-CCKA-Cholecystokinin-8-Gi1/β1/γ2
27.27Single7EZMCholecystokinin-87EZM-CCKA-Cholecystokinin-8-chim(NtGsL-Gq)/β1/γ2
27.27Single7LLLExendin-47LLL-GLP-1-Exendin-4-Gs/β1/γ2
27.27Single8GAGPubChem 1708384908GAG-CB1-PubChem 170838490-Gi1/β1/γ2
27.27Single8ID8TUG-8918ID8-FFA4-TUG-891-Gi1/β1/γ2
27.27Single9GE3Lysophosphatidylinositol9GE3-GPR55-Lysophosphatidylinositol-chim(CtGi1-G13)/β1/γ2
27.27Consensusccka_onOrthosteric Ligand7EZH-CCKA-Cholecystokinin-8-Gi1/β1/γ2
27.27Consensusccka_on_gpOrthosteric Ligand7EZH-CCKA-Cholecystokinin-8-Gi1/β1/γ2
27.27Consensuschemerin_onOrthosteric Ligandcml1_on
26.92Single6WI9Secretin6WI9-Secretin-Secretin-Gs/β1/γ2
26.92Single7F4HAfamelanotide7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2
26.92Single7FIMTirzepatide7FIM-GLP-1-Tirzepatide-Gs/β1/γ2
26.92Single7V9MSomatoliberin7V9M-GHRH (SV1)-Somatoliberin-Gs/β1/γ2
26.92Single7YONPeptide-YY(3-36)7YON-Y2-Peptide-YY(3-36)-Gi1/β1/γ2
26.92Single8WSTPro-MCH8WST-MCH2-Pro-MCH-chim(NtGi1L-Gs-CtGq)/β1/γ2
26.92Consensusc5a1_on_gpOrthosteric Ligand8HK5-C5a1-Complement C5-Gi1/β1/γ2 7Y66-C5a1-BM213-Gi1/β1/γ2 7Y67-C5a1-C089 peptide-Gi1/β1/γ2 7Y64-C5a1-C5a anaphylatoxin-Gi1/β1/γ2
26.92Consensusgi_formylpeptideOrthosteric Ligand7WVY-FPR2-ALX-Amyloid-β42-Gi2/β1/γ2 7T6U-FPR2-ALX-CGEN-855A-Gi1/β1/γ2 7VFX-FPR1-ALX-fMLF-Gi1/β1/γ2 7T6V-FPR2-ALX-fMLFII-Gi1/β1/γ2 7WVX-FPR2-ALX-Humanin-Gi2/β1/γ2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/β1/γ2 6OMM-FPR2-ALX-WKYMVX-Gi1/β1/γ2
26.92Consensusprotein_offonOrthosteric Ligandprotein_off protein_on
26.92Consensusprotein_offon_gpOrthosteric Ligandprotein_on_gp protein_off
26.67Single6TQ9SB-4081246TQ9-OX1-SB-408124
26.67Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
26.67Single8ZJETAK-4488ZJE-Kiss1-TAK-448-chim(NtGi1-Gq)/β1/γ1
26.67Consensusccr5_on_gpOrthosteric Ligand7O7F-CCR5-6P4-CCL5-Gi1/β1/γ1 7F1Q-CCR5-MIP-1a-Gi1/β1/γ2
26.32Single6D27CAY104716D27-DP2-CAY10471
26.32Single6GPSMK08126GPS-CCR2-MK0812
26.32Single6KPFPubChem 1459158896KPF-CB2-PubChem 145915889-Gi1/β1/γ2
26.32Single6XBM25(S)-Epoxycholesterol6XBM-SMO-25(S)-Epoxycholesterol-Gi1/β1/γ2
26.32Single6Z10PubChem 1545855546Z10-Succinate-PubChem 154585554
26.32Single7CFMP3957CFM-GPBA-P395-Gs/β1/γ2
26.32Single7NA8PubChem 1780247NA8-Ghrelin-PubChem 178024-Gi1/β1/γ2
26.32Single7PP1Selatogrel7PP1-P2Y12-Selatogrel
26.32Single7VIFS-FTY720-P7VIF-S1P1-S-FTY720-P-Gi1/β1/γ2
26.32Single7WC8Lumateperone7WC8-5-HT2A-Lumateperone
26.32Single7YU4ONO-07405567YU4-LPA1-ONO-0740556
26.32Single8IHJAcifran8IHJ-HCA3-Acifran-Gi1/β1/γ2
26.32Single8KEXDCA-3P8KEX-MRGPRX4-DCA-3P
26.32Single9AVGCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVG-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs)/β1/γ2
26.32Consensusccr2_offOrthosteric Ligand6GPS-CCR2-MK0812
26.32Consensuslipid_offOrthosteric Ligandcannabinoid_off paf_off lpl_off prostanoid_off leukotriene_off
26.09Single5EE7MK08935EE7-Glucagon-MK0893
26.09Single5VBLApelin mimetic peptide agonist5VBL-Apelin-Apelin mimetic peptide agonist
26.09Single6C1QPMX536C1Q-C5a1-PMX53-NDT9513727
26.09Single6XBJCholesterol6XBJ-SMO-Cholesterol-Gi1/β1/γ2
26.09Single7F9ZGHRP-67F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/β1/γ2
26.09Single7RKFFractalkine7RKF-US28-Fractalkine-GDP-chim(NtGi1-G11)/β1/γ2
26.09Single8XZFWN5618XZF-Apelin-WN561-Gi1/β1/γ2
26.09Consensusformylpeptide_onOrthosteric Ligandfpr2-alx_on fpr1-alx_on
26.09Consensusgq_cckOrthosteric Ligand8IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/β1/γ2 7XOW-CCKB-Gastrin-chim(NtGi1-Gq)/β1/γ2 7EZM-CCKA-Cholecystokinin-8-chim(NtGsL-Gq)/β1/γ2 7F8W-CCKB-Gastrin-17-chim(NtGsL-Gq)/β1/γ2
25.93Single7QBIAlpha-factor mating pheromone7QBI-STE2-α-factor mating pheromone
25.93Single7WBJPACAP277WBJ-VPAC1-PACAP27-Gs/β1/γ2
25.93Single8E3YPACAP278E3Y-VPAC1-PACAP27-Gs/β1/γ2
25.93Single8E3ZVIP8E3Z-VPAC1-VIP-Gs/β1/γ2
25.93Single8HCQEndothelin-18HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/β1/γ2
25.93Single8HCXEndothelin-18HCX-ETB-Endothelin-1-chim(NtGi2L-Gs-CtGq)/β1/γ2
25.93Single8HK5Complement C58HK5-C5a1-Complement C5-Gi1/β1/γ2
25.93Single8HNKCXCL118HNK-CXCR3-CXCL11-Gi1/β1/γ2
25.93Single8IA2C5a anaphylatoxin8IA2-C5a1-C5a anaphylatoxin-Go/β1/γ2
25.93Single8WWMMCH8WWM-MCH1-MCH-Gi1/β1/γ2
25.93Consensuseta_onOrthosteric Ligand8HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/β1/γ2
25.93Consensuseta_on_gpOrthosteric Ligand8HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/β1/γ2
25.81Single6LPBPACAP6LPB-PAC1-PACAP-Gs/β1/γ1
25.81Single8HBDIRL16208HBD-ETB-IRL1620-Gi1/β1/γ2
25.81Consensusendothelin_on_gpOrthosteric Ligandetb_on_gp eta_on_gp
25.81Consensusmelanocortin_onOrthosteric Ligandmc1_on mc4_on mc2_on mc3_on mc5_on
25.81Consensusmelanocortin_on_gpOrthosteric Ligandmc1_on_gp mc4_on_gp mc2_on_gp mc3_on_gp mc5_on_gp
25.00Single2J4Y11-cis-Retinal2J4Y-Rhodopsin-11-cis-Retinal
25.00Single3C9M11-cis-Retinal3C9M-Rhodopsin-11-cis-Retinal
25.00Single3PQRAll-trans-Retinal3PQR-Rhodopsin-All-trans-Retinal-Gt(CT)
25.00Single4NTJAZD12834NTJ-P2Y12-AZD1283
25.00Single4WW3All-trans-Retinal4WW3-Rhodopsin-All-trans-Retinal
25.00Single4XT1Fractalkine4XT1-US28-Fractalkine
25.00Single5CGCHTL142425CGC-mGlu5-HTL14242
25.00Single5WKTOctyl-Beta-D-Glucopyranoside5WKT-Rhodopsin-Octyl-β-D-Glucopyranoside-Gt(CT)
25.00Single6GPXMK08126GPX-CCR2-MK0812
25.00Single6ME5Agomelatine6ME5-MT1-Agomelatine
25.00Single6WIVPubChem 52923113; PubChem 529246456WIV-GABAB1, GABAB2-PubChem 52923113; PubChem 52924645
25.00Single7C4SS1P7C4S-S1P3-S1P
25.00Single7E9GJNJ-404118137E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/β1/γ2
25.00Single7F54Afamelanotide7F54-MC4-Afamelanotide-Gs/β1/γ2
25.00Single7MT8All-trans-Retinal7MT8-Rhodopsin-All-trans-Retinal-GRK1
25.00Single7MT9All-trans-Retinal7MT9-Rhodopsin-All-trans-Retinal-GRK1
25.00Single7MTAAll-trans-Retinal7MTA-Rhodopsin-All-trans-Retinal-GRK1
25.00Single7QA8Peptide7QA8-STE2-Peptide
25.00Single7QA8Peptide7QA8-STE2-Peptide
25.00Single7QBIAlpha-factor mating pheromone7QBI-STE2-α-factor mating pheromone
25.00Single7TD3S1P7TD3-S1P1-S1P-Gi1/β1/γ2
25.00Single7TD4Siponimod7TD4-S1P1-Siponimod-Gi1/β1/γ2
25.00Single7VABNon-Acylated Tirzepatide7VAB-GIP-Non-Acylated Tirzepatide-chim(NtGi1-Gs)/β1/γ2
25.00Single7W53Neuromedin-U-257W53-NMUR1-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
25.00Single7WC5Psilocin7WC5-5-HT2A-Psilocin
25.00Single7XMRSomatostatin-147XMR-SST2-Somatostatin-14-Gi1/β1/γ2
25.00Single7Y26Octreotide7Y26-SST2-Octreotide-chim(NtGi2L-Gs-CtGq)/β1/γ2
25.00Single7YU3ONO-07405567YU3-LPA1-ONO-0740556-Gi1/β1/γ2
25.00Single8E3XPACAP278E3X-PAC1-PACAP27-Gs/β1/γ2
25.00Single8EITDoconexent8EIT-FFA1-Doconexent-chim(NtGi1L-Gs-CtGq)/β1/γ2
25.00Single8IU2Retinal8IU2-Opsin1LW-Retinal-Gi1/β1/γ2
25.00Single8IZBLysophosphatidylserine8IZB-GPR174-Lysophosphatidylserine-Gs/β1/γ2
25.00Single8WGBW9R8WGB-mGlu4; mGlu2-Glutammate-W9R-Gi3/β1/γ2
25.00Single8WZ2Orexigenic Neuropeptide QRFP8WZ2-QRFP-Orexigenic Neuropeptide QRFP-chim(NtGi1L-Gs-CtGq)/β1/γ2
25.00Single8X0DVU04244658X0D-mGlu5; mGlu5-Quisqualate-VU0424465
25.00Single8X0DVU04244658X0D-mGlu5; mGlu5-Quisqualate-VU0424465
25.00Single8XGMChemerin8XGM-CML2-Chemerin-Gi1/β1/γ2
25.00Single9IV15alpha-DHT9IV1-ADGRD1-5α-DHT-chim(NtGi1-Gs)/β1/γ2
25.00Single9L3YRetinoic acid receptor responder protein 29L3Y-CML2-Retinoic acid receptor responder protein 2-Gi1/β1/γ2
25.00Consensusblt1_offOrthosteric Ligand5X33-BLT1-BIIL260 7K15-BLT1-MKD046-Na
25.00Consensusblt_offOrthosteric Ligandblt1_off
25.00Consensuscxcr4_onOrthosteric Ligand8K3Z-CXCR4-CXCL12-Gi1/β1/γ1
25.00Consensusgi_opsinsOrthosteric Ligand8IU2-Opsin1LW-Retinal-Gi1/β1/γ2
25.00Consensusgi_sensoryOrthosteric Ligandgi_opsins
25.00Consensuslpa1_onOrthosteric Ligand7TD1-LPA1-LPA-Gi1/β1/γ2 7YU3-LPA1-ONO-0740556-Gi1/β1/γ2
25.00Consensuslpa1_on_gpOrthosteric Ligand7TD1-LPA1-LPA-Gi1/β1/γ2 7YU3-LPA1-ONO-0740556-Gi1/β1/γ2
25.00Consensusmc4_onOrthosteric Ligand7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2 7F58-MC4-THIQ-Gs/β1/γ2 7F54-MC4-Afamelanotide-Gs/β1/γ2 7F53-MC4-α-MSH-Gs/β1/γ2 7F55-MC4-Bremelanotide-Gs/β1/γ2
25.00Consensusnmur1_on_gpOrthosteric Ligand7W53-NMUR1-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
25.00Consensusopsin1lw_onOrthosteric Ligand8IU2-Opsin1LW-Retinal-Gi1/β1/γ2
25.00Consensusopsin1lw_on_gpOrthosteric Ligand8IU2-Opsin1LW-Retinal-Gi1/β1/γ2
25.00Consensusp2y_onOrthosteric Ligandp2y1_on p2y10_on p2y12_on
25.00Consensusrxfp4_onOrthosteric Ligand7YK7-RXFP4-DC591053-Gi2/β1/γ2 7YJ4-RXFP4-INSL5-Gi2/β1/γ2 7YK6-RXFP4-PubChem 138319674-Gi2/β1/γ2
25.00Consensusrxfp4_on_gpOrthosteric Ligand7YK7-RXFP4-DC591053-Gi2/β1/γ2 7YJ4-RXFP4-INSL5-Gi2/β1/γ2 7YK6-RXFP4-PubChem 138319674-Gi2/β1/γ2
25.00Consensuss1p_offOrthosteric Ligands1p1_off s1p5_off
24.14Single6B3JExendin-P56B3J-GLP-1-Exendin-P5-Gs/β1/γ2
24.14Single6VCBGLP-16VCB-GLP-1-GLP-1-LSN3160440-Gs/β1/γ2
24.14Single7QBCAlpha-factor mating pheromone7QBC-STE2-α-factor mating pheromone
24.00Single7C6A(Sar1,Ile8)-Angiotensin II7C6A-AT2-(Sar1,Ile8)-Angiotensin II
24.00Single7PIVSetmelanotide7PIV-MC4-Setmelanotide-Gs/β1/γ2
24.00Single8KH5Lysophosphatidylserine8KH5-GPR174-Lysophosphatidylserine-Gs/β1/γ2
24.00Single8WSSPro-MCH8WSS-MCH1-Pro-MCH-Gi1/β1/γ1
24.00Single8XYDPlatelet Activating Factor8XYD-PAF-Platelet Activating Factor-Gi1/β1/γ2
24.00Single9EAINanobody AT2099EAI-AT1-Losartan-Nanobody AT209
24.00Consensusgi_ghrelinOrthosteric Ligand7NA7-Ghrelin-Ghrelin-27-Gi1/β1/γ2 7NA8-Ghrelin-PubChem 178024-Gi1/β1/γ2
24.00Consensusmc4_on_gpOrthosteric Ligand7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2 7F58-MC4-THIQ-Gs/β1/γ2 7F54-MC4-Afamelanotide-Gs/β1/γ2 7F53-MC4-α-MSH-Gs/β1/γ2 7F55-MC4-Bremelanotide-Gs/β1/γ2
24.00Consensusmc5_onOrthosteric Ligand8INR-MC5-α-MSH-Ca-chim(NtGi1-Gs)/β1/γ2 8IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/β1/γ2
23.81Single5ZBHBMS-1938855ZBH-Y1-BMS-193885
23.81Single6O3CCholesterol6O3C-SMO-SAG21k-Cholesterol
23.81Single6RZ5Zafirlukast6RZ5-CysLT1-Zafirlukast-Na
23.81Single7R0CAVP7R0C-V2-AVP-Arrestin2
23.81Single7VIGCBP-3077VIG-S1P1-CBP-307-Gi1/β1/γ2
23.81Single7XOWGastrin7XOW-CCKB-Gastrin-chim(NtGi1-Gq)/β1/γ2
23.81Single7Y67C089 peptide7Y67-C5a1-C089 peptide-Gi1/β1/γ2
23.81Single7YU5ONO-07405567YU5-LPA1-ONO-0740556-Gi1/β1/γ2
23.81Single8GUSHU-3088GUS-CB2-HU-308-Gi1/β1/γ2
23.81Single8HQCC5a anaphylatoxin8HQC-C5a1-C5a anaphylatoxin-Go/β1/γ2
23.81Single8X0BVU04244658X0B-mGlu5; mGlu5-Quisqualate-VU0424465
23.81Single8X0FVU04244658X0F-mGlu5; mGlu5-Quisqualate-VU0424465
23.81Single8XJMLatanoprost8XJM-FP-alpha-Latanoprost-chim(NtGi2-Gs-CtGq)/β1/γ2
23.81Single8YNTSNAP-948478YNT-MCH1-SNAP-94847
23.81Single8ZR5Firuglipel8ZR5-GPR119-Firuglipel-Gs/β1/γ2
23.81Consensusffa_onOrthosteric Ligandffa2_on ffa3_on
23.81Consensusffa_on_gpOrthosteric Ligandffa2_on_gp ffa3_on_gp
23.81Consensusgi_ffaOrthosteric Ligand8J21-FFA3-Butyric acid-Gi1/β1/γ2 8J22-FFA2-TUG-1375-Gi1/β1/γ2
23.81Consensusgi_lpaOrthosteric Ligand7TD1-LPA1-LPA-Gi1/β1/γ2 7YU3-LPA1-ONO-0740556-Gi1/β1/γ2
23.81Consensusgi_relaxinOrthosteric Ligand7YK7-RXFP4-DC591053-Gi2/β1/γ2 7YJ4-RXFP4-INSL5-Gi2/β1/γ2 7YK6-RXFP4-PubChem 138319674-Gi2/β1/γ2
23.81Consensuslpa_onOrthosteric Ligandlpa1_on
23.81Consensuslpa_on_gpOrthosteric Ligandlpa1_on_gp
23.81Consensusrelaxin_onOrthosteric Ligandrxfp4_on
23.81Consensusrelaxin_on_gpOrthosteric Ligandrxfp4_on_gp
23.53Single1L9H11-cis-Retinal1L9H-Rhodopsin-11-cis-Retinal
23.53Single3AYMAll-trans-Retinal3AYM-Rhodopsin-All-trans-Retinal
23.53Single3OE9IT1t3OE9-CXCR4-IT1t
23.53Single5TE520-Methanoretinal5TE5-Rhodopsin-20-Methanoretinal
23.53Single6PGSGeraniol6PGS-Rhodopsin-Geraniol-Gt(CT)
23.53Single7V68Iperoxo7V68-M4-Iperoxo-PubChem 57664406-Gi1/β1/γ2
23.53Single7VUIJNJ-635330547VUI-GPR139-JNJ-63533054-GTP-chim(Gs-CtGq)/β1/γ2
23.53Single7XP6Strychnine7XP6-T2R46-Strychnine-chim(Gs-CtGt3)/β1/γ2
23.53Single8IHIAcifran8IHI-HCA2-Acifran-Gi1/β1/γ2
23.53Single8JILNiacin8JIL-HCA2-Niacin-Gi1/β1/γ2
23.53Single9EPRRetinal9EPR-Rhodopsin-Retinal-Gi1/β1/γ2
23.33Single6WZGSecretin6WZG-Secretin-Secretin-Gs/β1/γ2
23.33Single7KI1Taspoglutide7KI1-GLP-1-Taspoglutide-Gs/β1/γ2
23.33Single7QBCAlpha-factor mating pheromone7QBC-STE2-α-factor mating pheromone
23.33Single8F0KPramlintide Analogue San3858F0K-CT (AMY3)-Pramlintide Analogue San385-Gs/β1/γ2; RAMP3
23.33Single8IY6Endothelin-18IY6-ETB-Endothelin-1
23.33Single8KGGLPS8KGG-P2Y10-LPS-chim(NtGi2-G13)/β1/γ2
23.33Consensusgs_melanocortinOrthosteric Ligand7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2 7F54-MC4-Afamelanotide-Gs/β1/γ2 7F4D-MC1-α-MSH-chim(NtGi1-Gs)/β1/γ2 8INR-MC5-α-MSH-Ca-chim(NtGi1-Gs)/β1/γ2 7F53-MC4-α-MSH-Gs/β1/γ2 7F55-MC4-Bremelanotide-Gs/β1/γ2 8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1 8IOC-MC3-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2 8IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/β1/γ2 7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2 7F4I-MC1-SHU9119-chim(NtGi1-Gs)/β1/γ2 7F58-MC4-THIQ-Gs/β1/γ2
23.08Single6LW5WKYMVm6LW5-FPR2-ALX-WKYMVm
23.08Single6MEOEnvelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd46MEO-CCR5-Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4
23.08Single6VN7PACAP6VN7-VPAC1-PACAP-Gs/β1/γ2
23.08Single7F4DAlpha-MSH7F4D-MC1-α-MSH-chim(NtGi1-Gs)/β1/γ2
23.08Single7RYCOxytocin7RYC-OT-Oxytocin-chim(NtGi2L-Gs-CtGq)/β1/γ2
23.08Single8K6MNeuropeptide-Y8K6M-Y1-Neuropeptide-Y-Gi2/β1/γ1
23.08Consensusnpy1_onOrthosteric Ligand8K6M-Y1-Neuropeptide-Y-Gi2/β1/γ1
23.08Consensusnpy1_on_gpOrthosteric Ligand8K6M-Y1-Neuropeptide-Y-Gi2/β1/γ1
22.86Consensusmc2_onOrthosteric Ligand8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1
22.86Consensusmc2_on_gpOrthosteric Ligand8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1
22.73Single4N4WSANT-14N4W-SMO-SANT-1
22.73Single6C1RPMX536C1R-C5a1-PMX53-Avacopan; Na
22.73Single6KPGAM8416KPG-CB1-AM841-Gi1/β1/γ2
22.73Single6W2YPubChem 237279706W2Y-GABAB1; GABAB1-PubChem 5311042-PubChem 23727970
22.73Single7F55Bremelanotide7F55-MC4-Bremelanotide-Gs/β1/γ2
22.73Single7W0NElabela7W0N-Apelin-Elabela-Gi1/β1/γ2
22.73Single7XZ5Lysophosphatidylcholine7XZ5-GPR119-Lysophosphatidylcholine-Gs/β1/γ2
22.73Single8JJPChemerin8JJP-CML2-Chemerin-Gi1/β1/γ2
22.73Consensuscxcr_onOrthosteric Ligandcxcr3_on cxcr4_on cxcr1_on cxcr2_on
22.73Consensusffa2_on_gpOrthosteric Ligand8J22-FFA2-TUG-1375-Gi1/β1/γ2
22.58Single6PB0Urocortin6PB0-CRF1-Urocortin-chim(NtGi1-Gs)/β1/γ2
22.58Single7DUQGLP-17DUQ-GLP-1-GLP-1-PubChem 156022738-Gs/β1/γ2
22.58Single8U1UCCL18U1U-CCR8-CCL1-Gi1/β1/γ2
22.22Single2Z7311-cis-Retinal2Z73-Rhodopsin-11-cis-Retinal
22.22Single3AYN9-cis-Retinal3AYN-Rhodopsin-9-cis-Retinal
22.22Single5WB2CX3CL1.355WB2-US28-CX3CL1.35
22.22Single6M1IPACAP6M1I-PAC1-PACAP-Gs/β1/γ2
22.22Single6ME9Ramelteon6ME9-MT2-Ramelteon
22.22Single6METEnvelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd46MET-CCR5-Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4
22.22Single6TQ6PubChem 1457142836TQ6-OX1-PubChem 145714283
22.22Single6WIVPubChem 52923113; PubChem 529246456WIV-GABAB1, GABAB2-PubChem 52923113; PubChem 52924645
22.22Single7AD3Alpha-factor mating pheromone7AD3-STE2-α-factor mating pheromone-Gi1/STE4/γ2
22.22Single7F16TIP397F16-PTH2-TIP39-Gs/β1/γ2
22.22Single7F8YDevazepide7F8Y-CCKA-Devazepide
22.22Single7T10Somatostatin-147T10-SST2-Somatostatin-14-Gi3/β1/γ2
22.22Single7W0OElabela7W0O-Apelin-Elabela-Gi1/β1/γ2
22.22Single7W57Neuromedin-S7W57-NMUR2-Neuromedin-S-chim(NtGi1-Gs-CtGq)/β1/γ2
22.22Single7WF7S1P7WF7-S1P1-S1P-Gi1/β1/γ2
22.22Single7WUIIP157WUI-ADGRG2-IP15-chim(NtGi1-Gs)/β1/γ2
22.22Single7XK8Neuromedin-U-257XK8-NMUR2-Neuromedin-U-25-Gi1/β1/γ2
22.22Single8A6CAll-trans-Retinal8A6C-Rhodopsin-All-trans-Retinal
22.22Single8A6DAll-trans-Retinal8A6D-Rhodopsin-All-trans-Retinal
22.22Single8A6EAll-trans-Retinal8A6E-Rhodopsin-All-trans-Retinal
22.22Single8H8JLodoxamide8H8J-GPR35-Lodoxamide-Ca-chim(NtGi1L-G13)/β1/γ2
22.22Single8IEDA1LYA8IED-GPR156-A1LYA-Go/β1/γ2
22.22Single8SZGCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-chim(NtGi1-Gq)/β1/γ2
22.22Single8U4PAMD31008U4P-CXCR4-AMD3100-Cholesterol-Gi1/β1/γ2
22.22Single8UTDMK19038UTD-HCA2-MK1903-Gi1/β1/γ2
22.22Single8XZJWN3538XZJ-Apelin-WN353-Gi1/β1/γ2
22.22Single8YW4Retatrutide8YW4-GIP-Retatrutide-chim(NtGi1-Gs)/β1/γ22
22.22Single9AVLCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVL-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi3/β2/γ2
22.22Single9C2FCa; Ca; Tryptophan; '6218; PO49C2F-CaS-Ca-Ca; Ca; Tryptophan; '6218; PO4
22.22Consensusmc5_on_gpOrthosteric Ligand8INR-MC5-α-MSH-Ca-chim(NtGi1-Gs)/β1/γ2 8IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/β1/γ2
22.22Consensusp2y_on_gpOrthosteric Ligandp2y1_on_gp p2y10_on_gp p2y12_on_gp
21.88Single8FLSAbaloparatide8FLS-PTH1-Abaloparatide-Gs/β1/γ2
21.88Single8FLULong-Acting PTH8FLU-PTH1-Long-Acting PTH-Gs/β1/γ2
21.74Single5CGDHTL142425CGD-mGlu5-HTL14242
21.74Single7QVMOxytocin7QVM-OT-Oxytocin-chim(NtGi1-Go-CtGq)/β1/γ2
21.74Single8IULLatanoprost8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/β1/γ2
21.74Single8XJKCloprosetnol8XJK-FP-alpha-Cloprosetnol-chim(NtGi1-Gs-CtGq)/β1/γ2
21.74Single8ZX4Lysophosphatidylinositol 8ZX4-GPR55-Lysophosphatidylinositol-chim(NtGi1-G13)/β1/γ2
21.74Consensusfp-alpha_on_gpOrthosteric Ligand8IUK-FP-alpha-PGF2-α-chim(NtGi1-Gs-CtGq)/β1/γ2 8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/β1/γ2 8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/β1/γ2
21.74Consensusnk2_onOrthosteric Ligand7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
21.43Single4A4MAll-trans-Retinal4A4M-Rhodopsin-All-trans-Retinal-Gt(CT)
21.43Single5EN0All-trans-Retinal5EN0-Rhodopsin-All-trans-Retinal-Gt(CT)
21.43Single6X18GLP-16X18-GLP-1-GLP-1-Gs/β1/γ2
21.43Single7LLYOxyntomodulin7LLY-GLP-1-Oxyntomodulin-Gs/β1/γ2
21.43Single8WCBCyclohexylammonium Ion8WCB-TA1-Cyclohexylammonium Ion-chim(NtGi1-Gs-CtGq)/β1/γ2
21.43Single8WCCCyclohexylammonium Ion8WCC-TA1-Cyclohexylammonium Ion
21.43Single8XVIEndothelin-18XVI-ETA-Endothelin-1-chim(Gs-CtGq)/β1/γ2
21.43Consensuschemokine_offOrthosteric Ligandccr_off cxcr_off
21.43Consensuschemokine_on_gpOrthosteric Ligandccr_on_gp cxcr_on_gp
21.43Consensuscxcr_offOrthosteric Ligandcxcr3_off cxcr4_off
21.43Consensusgi_chemokineOrthosteric Ligand6WWZ-CCR6-CCL20-Go/β1/γ2 8HNK-CXCR3-CXCL11-Gi1/β1/γ2 8K3Z-CXCR4-CXCL12-Gi1/β1/γ1 8IC0-CXCR1-Interleukin-8-Gi1/β1/γ2 6LFM-CXCR2-Interleukin-8-Gi1/β1/γ2 8KFX-CCR8-LMD-009-Gi1/β1/γ2 7F1Q-CCR5-MIP-1a-Gi1/β1/γ2 8HNL-CXCR3-PS372424-Gi1/β1/γ2 8KFY-CCR8-ZK-756326-Gi1/β1/γ2 7O7F-CCR5-6P4-CCL5-Gi1/β1/γ1 8U1U-CCR8-CCL1-Gi1/β1/γ2 7VLA-CCR1-CCL15(27-92)-Gi1/β1/γ2 7XA3-CCR2-CCL2-Gi1/β1/γ2
21.21Single7VVMPTH7VVM-PTH1-PTH-Gs/β1/γ2
21.05Single6FK8PubChem 1324730356FK8-Rhodopsin-PubChem 132473035
21.05Single6PELCitronellol6PEL-Rhodopsin-Citronellol-Gt(CT)
21.05Single6TPKRetosiban6TPK-OT-Retosiban
21.05Single7VODCariprazine7VOD-5-HT2A-Cariprazine
21.05Single7WVUfMLF7WVU-FPR1-ALX-fMLF-Gi1/β1/γ2
21.05Single8H4LDoconexent8H4L-FFA4-Doconexent-chim(NtGi1-Gs-CtGq)/β1/γ2
21.05Single8K2WAMG4878K2W-CXCR3-AMG487
21.05Single8K4SDCA-3P8K4S-MRGPRX4-DCA-3P-chim(NtGi1L-Gs-CtGq)/β1/γ2
21.05Consensuscxcr3_offOrthosteric Ligand8K2W-CXCR3-AMG487
21.05Consensusot_offOrthosteric Ligand6TPK-OT-Retosiban
21.05Consensusvasop-oxy_offOrthosteric Ligandot_off
20.83Single6OMMWKYMVX6OMM-FPR2-ALX-WKYMVX-Gi1/β1/γ2
20.83Single7RKNFractalkine7RKN-US28-Fractalkine-Gi1/β1/γ2
20.83Single7XBXCX3CL17XBX-CX3CR1-CX3CL1-Gi1/β1/γ2
20.83Single8IUMTafluprost acid8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/β1/γ2
20.83Single8J22TUG-13758J22-FFA2-TUG-1375-Gi1/β1/γ2
20.83Single8JBFSenktide8JBF-NK3-Senktide-chim(NtGi1-Gs-CtGq)/β1/γ2
20.83Single8Z74Agonistic antibody8Z74-Apelin-Agonistic antibody
20.83Single8Z74Agonistic antibody8Z74-Apelin-Agonistic antibody
20.83Consensuskiss1_onOrthosteric Ligand8ZJD-Kiss1-Kisspeptin-10-chim(NtGi1-Gq)/β1/γ1
20.83Consensuskisspeptin_onOrthosteric Ligandkiss1_on
20.83Consensusnmur1_onOrthosteric Ligand7W53-NMUR1-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
20.69Single4XT3Fractalkine4XT3-US28-Fractalkine
20.69Single5UIW5P7-CCL55UIW-CCR5-5P7-CCL5
20.69Single6FJ3PTH6FJ3-PTH1-PTH
20.69Single6P9YPACAP6P9Y-PAC1-PACAP-Gs/β1/γ2
20.69Single7D3SSecretin7D3S-Secretin-Secretin-Gs/β1/γ2
20.69Single7RA3GIP7RA3-GIP-GIP-chim(NtGi1-Gs)/β1/γ2
20.69Single7W3ZGastrin Releasing Peptide7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/β1/γ2
20.69Single8JISPeptide-158JIS-GLP-1-Peptide-15-chim(NtGi1-Gs)/β1/γ2
20.69Single9J1Pg1:Ox9J1P-GLP-1-g1:Ox-chim(NtGi1-Gs)/β1/γ2
20.69Consensusccr5_offOrthosteric Ligand5UIW-CCR5-5P7-CCL5
20.69Consensusccr_offOrthosteric Ligandccr2_off ccr5_off
20.59Single7Y36Teriparatide7Y36-PTH1-Teriparatide-Gs/β1/γ2
20.59Single8FLQPTH8FLQ-PTH1-PTH-Gs/β1/γ2
20.00Single5NDDAZ8838; Na5NDD-PAR2-AZ8838; Na
20.00Single5TGZAM65385TGZ-CB1-AM6538
20.00Single6FK7PubChem 1324730346FK7-Rhodopsin-PubChem 132473034
20.00Single6FKCPubChem 1324730396FKC-Rhodopsin-PubChem 132473039
20.00Single6FKDPubChem 1373491836FKD-Rhodopsin-PubChem 137349183
20.00Single7AD3Alpha-factor mating pheromone7AD3-STE2-α-factor mating pheromone-Gi1/STE4/γ2
20.00Single7DTYGIP7DTY-GIP-GIP-Gs/β1/γ2
20.00Single7FIYTirzepatide7FIY-GIP-Tirzepatide-Gs/β1/γ2
20.00Single7NA7Ghrelin-277NA7-Ghrelin-Ghrelin-27-Gi1/β1/γ2
20.00Single7S1MEx4-D-Ala7S1M-GLP-1-Ex4-D-Ala-Gs/β1/γ2
20.00Single7TYFAmylin7TYF-CT (AMY1)-Amylin-Gs/β1/γ2; RAMP1
20.00Single7VQXPACAP277VQX-VPAC1-PACAP27-Gs/β1/γ2
20.00Single7W56Neuromedin-S7W56-NMUR1-Neuromedin-S-chim(NtGi1-Gs-CtGq)/β1/γ2
20.00Single7WC4Serotonin7WC4-5-HT2A-Serotonin
20.00Single7YXAONO-54306087YXA-S1P5-ONO-5430608
20.00Single8IEBA1LYA8IEB-GPR156-A1LYA
20.00Single8KFYZK-7563268KFY-CCR8-ZK-756326-Gi1/β1/γ2
20.00Single8KIGSHU91198KIG-MC3-SHU9119-Ca
20.00Single8U4OCXCL128U4O-CXCR4-CXCL12-Cholesterol-Gi1/β1/γ2
20.00Single8XBGS3E-LysoPS8XBG-GPR34-S3E-LysoPS
20.00Single8XBHS3E-LysoPS8XBH-GPR34-S3E-LysoPS-Gi1/β1/γ2
20.00Single8ZCJPasireotide8ZCJ-SST5-Pasireotide-Gi1/β1/γ1
20.00Single8ZJDKisspeptin-108ZJD-Kiss1-Kisspeptin-10-chim(NtGi1-Gq)/β1/γ1
20.00Single9IV25alpha-DHT9IV2-ADGRD1-5α-DHT-chim(NtGi1-Gs)/β1/γ2
20.00Single9IYAONO-97105319IYA-GPR55-ONO-9710531
20.00Consensusalicarboxylic_offOrthosteric Ligandsuccinate_off
20.00Consensusgq_kisspeptinOrthosteric Ligand8ZJD-Kiss1-Kisspeptin-10-chim(NtGi1-Gq)/β1/γ1
20.00Consensuskiss1_on_gpOrthosteric Ligand8ZJD-Kiss1-Kisspeptin-10-chim(NtGi1-Gq)/β1/γ1
20.00Consensuskisspeptin_on_gpOrthosteric Ligandkiss1_on_gp
20.00Consensusnk3_onOrthosteric Ligand8JBF-NK3-Senktide-chim(NtGi1-Gs-CtGq)/β1/γ2
20.00Consensusnk3_on_gpOrthosteric Ligand8JBF-NK3-Senktide-chim(NtGi1-Gs-CtGq)/β1/γ2
20.00Consensusp2y10_on_gpOrthosteric Ligand8KGG-P2Y10-LPS-chim(NtGi2-G13)/β1/γ2
20.00Consensussuccinate_offOrthosteric Ligand6RNK-Succinate-NF-56-EJ40 6Z10-Succinate-PubChem 154585554
19.51Single8GY7Corticotropin8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1
19.35Single5VAIGLP-15VAI-GLP-1-GLP-1-Gs/β1/γ2
19.35Single6LMLGlucagon6LML-Glucagon-Glucagon-Gi1/β1/γ1
19.35Single6NBHLong-Acting PTH Analog6NBH-PTH1-Long-Acting PTH Analog-Gs/β1/γ2
19.35Single6PB1Urocortin6PB1-CRF2-Urocortin-chim(NtGi1-Gs)/β1/γ2
19.35Single7D68GLP-27D68-GLP-2-GLP-2-Gs/β1/γ2
19.35Single7VVJPTHrP(1-36)7VVJ-PTH1-PTHrP(1-36)-Gs/β1/γ2
19.35Single8HAFPTHrP(1-36)8HAF-PTH1-PTHrP(1-36)-chim(NtGi1-Gs)/β1/γ2
19.23Single7SK5CXCL127SK5-ACKR3-CXCL12
19.23Single7VBINon-Acylated Tirzepatide7VBI-GLP-1-Non-Acylated Tirzepatide-Gs/β1/γ2
19.23Single8K6OPro-neuropeptide-Y8K6O-Y1-Pro-neuropeptide-Y-Gi2/β1/γ1
19.05Single5T1APubChem 68764898; PubChem 120931705T1A-CCR2-PubChem 68764898; PubChem 12093170
19.05Single5YHLPubChem 1351213525YHL-EP4-PubChem 135121352
19.05Single5YWYONO-AE3-2085YWY-EP4-ONO-AE3-208
19.05Single6RZ4Pranlukast6RZ4-CysLT1-Pranlukast-Na
19.05Single6W2XPubChem 237279706W2X-GABAB1, GABAB2-PubChem 5311042-PubChem 23727970
19.05Single6XBKCholesterol6XBK-SMO-Cholesterol-Gi1/β1/γ2
19.05Single7VV4Cortistatin-147VV4-MRGPRX2-Cortistatin-14
19.05Single8GD9Rivenprost8GD9-EP4-Rivenprost-Gs/β1/γ2
19.05Single8X0BVU04244658X0B-mGlu5; mGlu5-Quisqualate-VU0424465
19.05Single8X0CVU04244658X0C-mGlu5; mGlu5-Quisqualate-VU0424465
19.05Single8X0CVU04244658X0C-mGlu5; mGlu5-Quisqualate-VU0424465
19.05Single9DQJEP-39459DQJ-MRGPRD-EP-3945-chim(NtGi1-Gs-CtGq)/β1/γ2
19.05Consensuscyslt_offOrthosteric Ligandcyslt2_off cyslt1_off
19.05Consensusep4_offOrthosteric Ligand5YWY-EP4-ONO-AE3-208 5YHL-EP4-PubChem 135121352
19.05Consensusep_offOrthosteric Ligandep4_off
19.05Consensuss1p5_offOrthosteric Ligand7YXA-S1P5-ONO-5430608
18.75Single2HPYAll-trans-Retinal2HPY-Rhodopsin-All-trans-Retinal
18.75Single3OE8IT1t3OE8-CXCR4-IT1t
18.75Single6OT025(S)-Epoxycholesterol6OT0-SMO-25(S)-Epoxycholesterol-Gi1/β1/γ2
18.75Single9C2FCa; Ca; Tryptophan; '6218; PO49C2F-CaS-Ca-Ca; Ca; Tryptophan; '6218; PO4
18.52Single3OE0CVX153OE0-CXCR4-CVX15
18.52Single6UUNAdrenomedullin6UUN-CT Like (AM1)-Adrenomedullin-Gs/β1/γ2; RAMP2
18.52Single7O7F6P4-CCL57O7F-CCR5-6P4-CCL5-Gi1/β1/γ1
18.52Single7XA3CCL27XA3-CCR2-CCL2-Gi1/β1/γ2
18.52Consensusccr2_onOrthosteric Ligand7XA3-CCR2-CCL2-Gi1/β1/γ2
18.52Consensusccr2_on_gpOrthosteric Ligand7XA3-CCR2-CCL2-Gi1/β1/γ2
18.52Consensusccr_onOrthosteric Ligandccr6_on ccr8_on ccr2_on ccr1_on ccr5_on
18.18Single4OO9Mavoglurant4OO9-mGlu5-Mavoglurant
18.18Single7P2L4YI7P2L-mGlu5-4YI
18.18Single7S8MCortistatin-147S8M-MRGPRX2-Cortistatin-14-Gi1/β1/γ2
18.18Single7T9NPubChem 6440787T9N-TSH-M22 Fab-PubChem 644078-Gs/β1/γ2
18.18Single7TZFAmylin7TZF-CT (AMY3)-Amylin-Gs/β1/γ2; RAMP3
18.18Single7XWONeurokinin-A7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
18.18Single8I2GCompound 7163408I2G-FSH-Glycoprotein hormones α chain-Compound 716340-Gs/β1/γ2
18.18Single8IUKPGF2-alpha8IUK-FP-alpha-PGF2-α-chim(NtGi1-Gs-CtGq)/β1/γ2
18.18Single8JD5BQI; HZE; PEF8JD5-mGlu2; mGlu4-Glutamate-BQI; HZE; PEF-Gi1/β1/γ2
18.18Single8X79MRE-2698X79-I2-MRE-269-Gs/β1/γ2
18.18Single8XBIS3E-LysoPS8XBI-GPR34-S3E-LysoPS
18.18Single9ASTLymphotactin9AST-XCR1-Lymphotactin-Gi1/β1/γ2
18.18Single9BJKNAM9BJK-μ-Naloxone-NAM
18.18Single9GE2ML1849GE2-GPR55-ML184-Cholesterol-chim(CtGi1-G13)/β1/γ2
18.18Consensusffa2_onOrthosteric Ligand8J22-FFA2-TUG-1375-Gi1/β1/γ2
18.18Consensusmotilin_onOrthosteric Ligand8IBU-Motilin-Erythromycin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
18.18Consensusnk2_on_gpOrthosteric Ligand7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
17.86Single8HA0PTH8HA0-PTH1-PTH-chim(NtGi1-Gs)/β1/γ2
17.86Single8IEDA1LYA8IED-GPR156-A1LYA-Go/β1/γ2
17.86Single8YW3Retatrutide8YW3-GLP-1-Retatrutide-Gs/β1/γ2
17.86Consensusneuromedin-u_onOrthosteric Ligandnmur1_on nmur2_on
17.65Single3OE6IT1t3OE6-CXCR4-IT1t
17.65Single6FK9PubChem 1324730366FK9-Rhodopsin-PubChem 132473036
17.65Single6WPWGlucagon derivative ZP37806WPW-Glucagon-Glucagon derivative ZP3780-Gs/β1/γ2
17.65Single7V6APubChem 98642757V6A-M4-PubChem 9864275-Gi1/β1/γ2
17.65Single8JEF(3S)-3-hydroxyoctanoic acid8JEF-HCA3-(3S)-3-hydroxyoctanoic acid-Gi1/β1/γ2
17.65Single8JIPMEDI03828JIP-GLP-1-MEDI0382-chim(NtGi1-Gs)/β1/γ2
17.65Single8JIRSAR4258998JIR-GLP-1-SAR425899-chim(NtGi1-Gs)/β1/γ2
17.65Single8RQLFlufenamic acid8RQL-TAS2R14-Flufenamic acid-Flufenamic acid-chim(NtGi1-Gt3)/β1/γ2
17.65Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
17.65Single8X9UMetenolone8X9U-ADGRD1-Metenolone-chim(NtGi1-Gs)/β1/γ2
17.65Single9C1PCa; Tryptophan; '6218; PO49C1P-CaS-Ca-Ca; Tryptophan; '6218; PO4
17.65Single9C1PCa; Tryptophan; '6218; PO49C1P-CaS-Ca-Ca; Tryptophan; '6218; PO4
17.65Single9JR2PTH9JR2-PTH1-PTH-chim(NtGi1L-Gs-CtGq)/β1/γ2
17.39Single4PXZ2MeSADP4PXZ-P2Y12-2MeSADP
17.39Single5TZYMK8666; PubChem 1270535975TZY-FFA1-MK8666; PubChem 127053597
17.39Single5X33BIIL2605X33-BLT1-BIIL260
17.39Single6OS2TRV0266OS2-AT1-TRV026
17.39Single7XW5ML1097XW5-TSH-TSH-ML109-Gs/β1/γ2
17.39Single7XW6ML1097XW6-TSH-M22 Fab-ML109-Gs/β1/γ2
17.39Single8GCPPGE28GCP-EP4-PGE2-Gi1/β1/γ2
17.39Single8H0QGastrin Releasing Peptide8H0Q-BB2-Gastrin Releasing Peptide-chim(NtGi1-Gs-CtGq)/β1/γ2
17.39Single8IBUErythromycin-A8IBU-Motilin-Erythromycin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
17.39Single8IQ6Latanoprost8IQ6-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/β1/γ2
17.39Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/β1/γ2
17.39Single8U26Protachykinin-18U26-NK1-Protachykinin-1-Gs/β1/γ2
17.39Single8WRBLysophosphatidylserine8WRB-GPR34-Lysophosphatidylserine-Gi1/β1/γ2
17.39Single8XJNCloprosetnol8XJN-TP-Cloprosetnol-chim(NtGi1-Gs-CtGq)/β1/γ2
17.39Single8XQSCholesterol8XQS-TAS2R14-Cholesterol-Flufenamic acid-Gi1/β1/γ1
17.39Consensusmotilin_on_gpOrthosteric Ligand8IBU-Motilin-Erythromycin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
17.24Single7F9YGhrelin-287F9Y-Ghrelin-Ghrelin-28-chim(NtGi1-Gs-CtGq)/β1/γ2
17.24Single7P02Protachykinin-17P02-NK1-Protachykinin-1-chim(NtGi1-Gs)/β1/γ2
17.24Single7VL9CCL15(26-92)7VL9-CCR1-CCL15(26-92)-Gi1/β1/γ2
17.24Consensusccr_on_gpOrthosteric Ligandccr6_on_gp ccr8_on_gp ccr2_on_gp ccr1_on_gp ccr5_on_gp
17.24Consensusneuromedin-u_on_gpOrthosteric Ligandnmur1_on_gp nmur2_on_gp
17.24Consensusp2y10_onOrthosteric Ligand8KGG-P2Y10-LPS-chim(NtGi2-G13)/β1/γ2
17.14Single9JR3PTH9JR3-PTH1-PTH-chim(NtGi1L-Gs-CtGq)/β1/γ2
16.67Single6E3YCalcitonin gene-related peptide-16E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/β1/γ2; RAMP1
16.67Single6FK6PubChem 1324730336FK6-Rhodopsin-PubChem 132473033
16.67Single6NBFLong-Acting PTH Analog6NBF-PTH1-Long-Acting PTH Analog-Gs/β1/γ2
16.67Single6PH7Nerol6PH7-Rhodopsin-Nerol-Gt(CT)
16.67Single7CZ5Somatoliberin7CZ5-GHRH-Somatoliberin-Gs/β1/γ2
16.67Single7D7MDinoprostone7D7M-EP4-Dinoprostone-Gs/β1/γ1
16.67Single7KI0Semaglutide7KI0-GLP-1-Semaglutide-Gs/β1/γ2
16.67Single7P00Substance-P7P00-NK1-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
16.67Single7PIUSetmelanotide7PIU-MC4-Setmelanotide-Gs/β1/γ2
16.67Single7SK4CXCL12_LRHQ7SK4-ACKR3-CXCL12_LRHQ
16.67Single7T96LY21196207T96-M2-Acetylcholine-LY2119620-Go/β1/γ2
16.67Single7TRPLY20332987TRP-M4-Iperoxo-LY2033298-Gi1/β1/γ2
16.67Single7VVNPTH7VVN-PTH1-PTH-Gs/β1/γ2
16.67Single7X8RBOC57X8R-GLP-1-BOC5-Gs/β1/γ2
16.67Single8HN1Toxin AdTx18HN1-Alpha1A-Toxin AdTx1
16.67Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/β1/γ2
16.67Single8XBES3E-LysoPS8XBE-GPR34-S3E-LysoPS-Gi1/β1/γ1
16.67Single8XJOU466198XJO-TP-U46619-chim(NtGi1-Gs-CtGq)/β1/γ2
16.67Single8ZX5AM2518ZX5-GPR55-AM251-chim(NtGi1-G13)/β1/γ2
16.67Single9B9Y7DY9B9Y-CB1-7DY
16.67Consensusccr5_onOrthosteric Ligand7O7F-CCR5-6P4-CCL5-Gi1/β1/γ1 7F1Q-CCR5-MIP-1a-Gi1/β1/γ2
16.67Consensusnk1_onOrthosteric Ligand7P00-NK1-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
16.67Consensusnk1_on_gpOrthosteric Ligand7P00-NK1-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
16.67Consensusprostanoid_onOrthosteric Ligandtp_on fp-alpha_on
16.67Consensusprostanoid_on_gpOrthosteric Ligandtp_on_gp fp-alpha_on_gp
16.67Consensustp_onOrthosteric Ligand8XJO-TP-U46619-chim(NtGi1-Gs-CtGq)/β1/γ2
16.67Consensustp_on_gpOrthosteric Ligand8XJO-TP-U46619-chim(NtGi1-Gs-CtGq)/β1/γ2
16.13Single6P9XCorticoliberin6P9X-CRF1-Corticoliberin-Gs/β1/γ2
16.13Single8FU6Glucagon derivative ZP37808FU6-Glucagon-Glucagon derivative ZP3780-Gs/β1/γ2
16.13Single8HAOPTH8HAO-PTH1-PTH-chim(NtGi1-Gs)/β1/γ2
16.00Single6RZ6ONO-25703666RZ6-CysLT2-ONO-2570366
16.00Single7AUESetmelanotide7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2
16.00Single7RMGSubstance-P7RMG-NK1-Substance-P-chim(Gs-CtGq)/β1/γ2
16.00Single7RMHSubstance-P7RMH-NK1-Substance-P-Gs/β1/γ2
16.00Single7S8LCortistatin-147S8L-MRGPRX2-Cortistatin-14-chim(NtGi2L-Gs-CtGq)/β1/γ2
16.00Single7X8SWB4-247X8S-GLP-1-WB4-24-Gs/β1/γ2
16.00Single8GDAL9026888GDA-EP4-L902688-Gs/β1/γ2
16.00Single8IEIA1LYA8IEI-GPR156-A1LYA
16.00Single8IQ4Carboprost8IQ4-FP-alpha-Carboprost-chim(NtGi1-Gs-CtGq)/β1/γ2
16.00Single8SAI1-Oleoyl-2-Hydroxy-Sn-Glycero-3-Phospho-L-Serine8SAI-GPR34-1-Oleoyl-2-Hydroxy-Sn-Glycero-3-Phospho-L-Serine-Gi1/β1/γ2
16.00Single9EAJNanobody AT2099EAJ-AT1-Nanobody AT209
16.00Consensuscxcr4_offOrthosteric Ligand4RWS-CXCR4-vMIP-II 3OE0-CXCR4-CVX15 3OE6-CXCR4-IT1t
15.79Single3ODUIT1t3ODU-CXCR4-IT1t
15.79Single4MQTLY21196204MQT-M2-Iperoxo-LY2119620
15.79Single5ZKQABT-4915ZKQ-PAF-ABT-491
15.79Single6FKBPubChem 1324730386FKB-Rhodopsin-PubChem 132473038
15.79Single6RNKNF-56-EJ406RNK-Succinate-NF-56-EJ40
15.79Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
15.79Single7S8PMS471347S8P-MRGPRX4-MS47134-chim(NtGi2L-Gs-CtGq)/β1/γ2
15.79Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
15.79Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
15.79Single7VDLCortistatin-147VDL-MRGPRX2-Cortistatin-14-Gi1/β1/γ2
15.79Single7X2CFenoldopam7X2C-D1-Fenoldopam-Fenoldopam-Gs/β1/γ2
15.79Consensuspaf_offOrthosteric Ligand5ZKQ-PAF-ABT-491
15.62Single7VVLPTH7VVL-PTH1-PTH-Gs/β1/γ2
15.62Single8FLTM-PTH(1-14)8FLT-PTH1-M-PTH(1-14)-Gs/β1/γ2
15.38Single7W2ZGhrelin7W2Z-Ghrelin-Ghrelin-Go/β1/γ2
15.38Single8F0JPramlintide Analogue San458F0J-CT-Pramlintide Analogue San45-Gs/β1/γ2
15.38Single8IEIA1LYA8IEI-GPR156-A1LYA
15.38Single8IEPA1LYA8IEP-GPR156-A1LYA
15.38Single8IEPA1LYA8IEP-GPR156-A1LYA
15.38Single8INRAlpha-MSH8INR-MC5-α-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
15.38Consensuschemokine_onOrthosteric Ligandccr_on cxcr_on
15.38Consensussomatostatin_offOrthosteric Ligandsst2_off
15.15Single7RBTTirzepatide7RBT-GIP-Tirzepatide-PubChem 163183774-chim(NtGi1-Gs)/β1/γ2
15.15Single7TYXAmylin7TYX-CT (AMY2)-Amylin-Gs/β1/γ2; RAMP2
15.00Single6FFIMMPEP6FFI-mGlu5-MMPEP
15.00Single6FKAPubChem 1324730376FKA-Rhodopsin-PubChem 132473037
15.00Single6U1NLY21196206U1N-M2-LY2119620-Arrestin2
15.00Single6WJCMuscarinic toxin 76WJC-M1-Atropine-Muscarinic toxin 7
15.00Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
15.00Single7T94PubChem 576644067T94-M2-Acetylcholine-PubChem 57664406-chim(NtGi1-Go)/β1/γ2
15.00Single8F2BPramlintide Analogue San458F2B-CT (AMY3)-Pramlintide Analogue San45-Gs/β1/γ2; RAMP3
15.00Single8HQN9-S-HODE8HQN-GPR132-9-S-HODE-Gi1/β1/γ2
15.00Single8K4NVF08K4N-GPR34-VF0-Gi1/β1/γ2
15.00Consensuscb1_offOrthosteric Ligand5U09-CB1-Taranabant 5TGZ-CB1-AM6538
14.81Single7F1QMIP-1a7F1Q-CCR5-MIP-1a-Gi1/β1/γ2
14.81Single7RMISubstance-P7RMI-NK1-Substance-P-chim(Gs-CtGq)/β1/γ2
14.81Single7XNACYN1548067XNA-SST2-CYN154806
14.81Single8IBVMotilin8IBV-Motilin-Motilin-chim(NtGi1-Gs-CtGq)/β1/γ2
14.81Single8IEBA1LYA8IEB-GPR156-A1LYA
14.81Single8JBHSubstance-P8JBH-NK3-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
14.81Consensussst2_offOrthosteric Ligand7XNA-SST2-CYN154806
14.81Consensustachykinin_on_gpOrthosteric Ligandnk1_on_gp nk2_on_gp nk3_on_gp
14.71Single7SK6CXCL12_LRHQ7SK6-ACKR3-CXCL12_LRHQ
14.71Single7VBHPeptide-207VBH-GLP-1-Peptide-20-Gs/β1/γ2
14.71Single9AUCCalcitonin gene-related peptide-19AUC-CT-Calcitonin gene-related peptide-1-Gs/β1/γ2; RAMP1
14.29Single6FFHFenobam6FFH-mGlu5-Fenobam
14.29Single6IIVDaltroban6IIV-TP-Daltroban
14.29Single7F83PF-051904577F83-Ghrelin-PF-05190457
14.29Single7LCIDanuglipron7LCI-GLP-1-Danuglipron-Gs/β1/γ2
14.29Single7LCKDanuglipron7LCK-GLP-1-Danuglipron
14.29Single7TRQVU04671547TRQ-M4-Iperoxo-VU0467154-Gi1/β1/γ2
14.29Single7V35Peptide-207V35-Glucagon-Peptide-20-Gs/β1/γ2
14.29Single7W55Neuromedin-U-257W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
14.29Single8GCML9026888GCM-EP4-L902688-Gi1/β1/γ2
14.29Single8X9TAP5038X9T-ADGRD1-AP503-chim(NtGi1-Gs)/β1/γ2
14.29Single8XJLPGF2-alpha8XJL-FP-alpha-PGF2-α-chim(NtGi2-Gs-CtGq)/β1/γ2
14.29Single8ZBEOctreotide8ZBE-SST5-Octreotide-Gi1/β1/γ1
14.29Single9IVMGLP-1 (Truncated)9IVM-GLP-1-GLP-1 (Truncated)-LSN3318839-chim(NtGi1-Gs)/β2/γ2
14.29Consensusmc3_onOrthosteric Ligand8IOC-MC3-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
14.29Consensusmc3_on_gpOrthosteric Ligand8IOC-MC3-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
14.29Consensusnmur2_onOrthosteric Ligand7W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
14.29Consensusnmur2_on_gpOrthosteric Ligand7W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
13.89Single7TYYCalcitonin-17TYY-CT (AMY2)-Calcitonin-1-Gs/β1/γ2; RAMP2
13.89Single8JIUSAR4258998JIU-Glucagon-SAR425899-Gs/β1/γ2
13.79Single7FINPeptide-20; GGL7FIN-GIP-Peptide-20; GGL-Gs/β1/γ2
13.79Single7TYIAmylin7TYI-CT-Amylin-Gs/β1/γ2
13.79Single8YW5Retatrutide8YW5-Glucagon-Retatrutide-Gs/β1/γ2
13.79Consensustachykinin_onOrthosteric Ligandnk1_on nk2_on nk3_on
13.64Single4PHUFasiglifam4PHU-FFA1-Fasiglifam
13.64Single6LFMInterleukin-86LFM-CXCR2-Interleukin-8-Gi1/β1/γ2
13.64Single6M9TMisoprostol-FA6M9T-EP3-Misoprostol-FA
13.64Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
13.64Single8GDCPGE28GDC-EP3-PGE2-Gi1/β1/γ2
13.64Single8IZ4Lysophosphatidylserine8IZ4-GPR34-Lysophosphatidylserine-Gi1/β1/γ2
13.64Single8SZICa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZI-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi3/β1/γ2
13.64Single9DQHEP-28259DQH-MRGPRD-EP-2825-chim(NtGi1-Gs-CtGq)/β1/γ2
13.64Consensuscxcr2_on_gpOrthosteric Ligand6LFM-CXCR2-Interleukin-8-Gi1/β1/γ2
13.33Single5YQZGlucagon analogue5YQZ-Glucagon-Glucagon analogue
13.33Single7Y35Abaloparatide7Y35-PTH1-Abaloparatide-Gs/β1/γ2
13.33Single8XOFLys058XOF-GPR30-Lys05-chim(NtGi1-Gs-CtGq)/β1/γ2
13.04Single5TZRMK86665TZR-FFA1-MK8666
13.04Single6OS1TRV0266OS1-AT1-TRV026
13.04Single7F1TMIP-1a7F1T-CCR5-MIP-1a
13.04Single7XBDGalanin7XBD-GAL2-Galanin-chim(NtGi2L-Gs-CtGq)/β1/γ2
13.04Single8FN1Neurotensin/Neuromedin-N8FN1-NTS1-Neurotensin/Neuromedin-N-chim(NtGi1-Go)/β1/γ2
13.04Single8GDBPGE28GDB-EP4-PGE2-Gs/β1/γ2
13.04Single8JBGNeurokinin-B8JBG-NK3-Neurokinin-B-chim(NtGi1-Gs-CtGq)/β1/γ2
13.04Single8TAOCDPPB8TAO-mGlu5; mGlu5-Quisqualate-CDPPB
13.04Single9ITELPA9ITE-LPA6-LPA-chim(NtGi2-G13)/β1/γ2
13.04Consensusp2y12_onOrthosteric Ligand7XXI-P2Y12-2MeSADP-Gi2/β1/γ2
12.90Single6NBILong-Acting PTH Analog6NBI-PTH1-Long-Acting PTH Analog-Gs/β1/γ2
12.90Single7SK3CXCL127SK3-ACKR3-CXCL12
12.90Single8FLRPTHrP(1-36)8FLR-PTH1-PTHrP(1-36)-Gs/β1/γ2
12.50Single3VW7Vorapaxar; Na3VW7-PAR1-Vorapaxar; Na
12.50Single4PY02MeSATP4PY0-P2Y12-2MeSATP
12.50Single4XEENeurotensin4XEE-NTS1-Neurotensin
12.50Single4XESNeurotensin4XES-NTS1-Neurotensin
12.50Single6AK3Dinoprostone IPGE26AK3-EP3-Dinoprostone IPGE2
12.50Single6IIURamatroban6IIU-TP-Ramatroban
12.50Single6RZ7ONO-25703666RZ7-CysLT2-ONO-2570366
12.50Single6UVAAdrenomedullin-26UVA-CT Like (AM2)-Adrenomedullin-2-Gs/β1/γ2; RAMP3
12.50Single7L0SNeurotensin7L0S-NTS1-Neurotensin-Gi1/β1/γ1
12.50Single7T6BS1P7T6B-S1P2-S1P-chim(NtGi1L-G13)/β1/γ2
12.50Single7TYNCalcitonin-17TYN-CT-Calcitonin-1-Gs/β1/γ2
12.50Single7V68PubChem 576644067V68-M4-Iperoxo-PubChem 57664406-Gi1/β1/γ2
12.50Single7VVKPTH7VVK-PTH1-PTH-Gs/β1/γ2
12.50Single7XKEBeta-Hydroxyandrosterone7XKE-ADGRG2-β-Hydroxyandrosterone-chim(NtGi1-Gs)/β1/γ2
12.50Single7XXI2MeSADP7XXI-P2Y12-2MeSADP-Gi2/β1/γ2
12.50Single8XQNCholesterol8XQN-TAS2R14-Cholesterol-Aristolochic acid A-Gi1/β1/γ1
12.50Single8ZPLHF511168ZPL-CXCR4-HF51116-Cholesterol
12.50Consensusgalanin_onOrthosteric Ligandgal2_on gal1_on
12.50Consensusgalanin_on_gpOrthosteric Ligandgal2_on_gp gal1_on_gp
12.50Consensusgi_p2yOrthosteric Ligand7XXI-P2Y12-2MeSADP-Gi2/β1/γ2
12.50Consensusp2y12_on_gpOrthosteric Ligand7XXI-P2Y12-2MeSADP-Gi2/β1/γ2
12.12Single6LMKGlucagon6LMK-Glucagon-Glucagon-Gs/β1/γ2
12.12Single6UUSAdrenomedullin6UUS-CT Like (AM2)-Adrenomedullin-Gs/β1/γ2; RAMP3
12.12Single7TYLAmylin7TYL-CT-Amylin-Gs/β1/γ2
12.00Single4BUONeurotensin4BUO-NTS1-Neurotensin
12.00Single6RZ9ONO-27703726RZ9-CysLT2-ONO-2770372
12.00Single8FN0Neurotensin/Neuromedin-N8FN0-NTS1-Neurotensin/Neuromedin-N-PubChem 118610427-chim(NtGi1-Go)/β1/γ2
12.00Single8K4OCXCL18K4O-KSHV-CXCL1-Gi1/β1/γ1
12.00Consensuscyslt2_offOrthosteric Ligand6RZ7-CysLT2-ONO-2570366 6RZ8-CysLT2-ONO-2080365 6RZ9-CysLT2-ONO-2770372
12.00Consensusgal2_onOrthosteric Ligand7WQ4-GAL2-Galanin-chim(NtGi1-Gs-CtGq)/β1/γ2 7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/β1/γ2
12.00Consensusgal2_on_gpOrthosteric Ligand7WQ4-GAL2-Galanin-chim(NtGi1-Gs-CtGq)/β1/γ2 7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/β1/γ2
11.54Single8XQJJN2418XQJ-Apelin-JN241
11.54Single8XQLCholesterol8XQL-TAS2R14-Cholesterol-Aristolochic acid A-Gt3/β1/γ1
11.54Single8XQOCholesterol8XQO-TAS2R14-Cholesterol-Aristolochic acid A-Gi1/β1/γ1
11.54Single9ITBLPA9ITB-LPA6-LPA-chim(NtGi1-Gs-CtGq)/β1/γ2
11.43Single8F2APramlintide Analogue San3858F2A-CT (AMY3)-Pramlintide Analogue San385-Gs/β1/γ2; RAMP3
11.11Single2ZIY11-cis-Retinal2ZIY-Rhodopsin-11-cis-Retinal
11.11Single6OIKLY21196206OIK-M2-Iperoxo-LY2119620-chim(NtGi1-Go)/β1/γ2
11.11Single6RZ8ONO-20803656RZ8-CysLT2-ONO-2080365
11.11Single6X19CHU-1286X19-GLP-1-CHU-128-Gs/β1/γ2
11.11Single7L0RNeurotensin7L0R-NTS1-Neurotensin-Gi1/β1/γ1
11.11Single8F76Propanoic acid8F76-OR51E2-Propanoic acid-Gs/β1/γ2
10.81Single7TYOCalcitonin7TYO-CT-Calcitonin-Gs/β1/γ2
10.81Single8JITMEDI03828JIT-Glucagon-MEDI0382-Gs/β1/γ2
10.71Single6WHCGlu16 analog of GCG6WHC-Glucagon-Glu16 analog of GCG-Gs/β1/γ2
10.71Single7E14Orforglipron7E14-GLP-1-Orforglipron-PubChem 156022738-Gs/β1/γ2
10.71Single7TRYUrocortin7TRY-CRF2-Urocortin-chim(NtGi1-G11)/β1/γ2
10.71Single8IOCGamma-MSH8IOC-MC3-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
10.53Single5L7IVismodegib5L7I-SMO-Vismodegib
10.53Single7D76Beclomethasone7D76-ADGRG3-Beclomethasone-Go/β1/γ2
10.53Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
10.53Single8U4RREGN7663-Fab8U4R-CXCR4-REGN7663-Fab-Cholesterol
10.53Single8X2KOleic monoethanolamide8X2K-GPR3-Oleic monoethanolamide-chim(NtGi1-Gs)/β1/γ2
10.53Single8YRGFospropofol8YRG-MRGPRX4-Fospropofol-chim(NtGi1-Gs-CtGq)/β1/γ2
10.00Single5U09Taranabant5U09-CB1-Taranabant
10.00Single6LFOInterleukin-86LFO-CXCR2-Interleukin-8-Gi1/β1/γ2
10.00Single6NIYAdrenomedullin6NIY-CT-Adrenomedullin-Gs/β1/γ2
10.00Single6ZA8RTI-3a6ZA8-NTS1-RTI-3a
10.00Single7LCJDanuglipron7LCJ-GLP-1-Danuglipron
10.00Single7XJJGalanin7XJJ-GAL1-Galanin-Go/β1/γ2
10.00Single8HMPC178HMP-GPR52-C17-Gs/β1/γ2
10.00Single8T3VDocosa-4,7,10,13,16,19-Hexaenoic acid8T3V-FFA1-Docosa-4,7,10,13,16,19-Hexaenoic acid-chim(NtGi2L-Gs-CtGq)/β1/γ2
10.00Single8U8FPalmitic Acid8U8F-GPR3-Palmitic Acid-Gs/β1/γ2
10.00Single9BA0A1AKN9BA0-CB1-A1AKN
10.00Consensuscxcr1_onOrthosteric Ligand8IC0-CXCR1-Interleukin-8-Gi1/β1/γ2
9.68Single7TYWCalcitonin-17TYW-CT (AMY1)-Calcitonin-1-Gs/β1/γ2; RAMP1
9.52Single6ZINSR486926ZIN-NTS1-SR48692
9.52Single7C2EPubChem 1490507997C2E-GLP-1-PubChem 149050799-Gs/β1/γ2
9.52Single7UTZPubChem 6440787UTZ-TSH-TR1402-PubChem 644078-Gs/β1/γ2
9.52Single7XXH2MeSADP7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/β1/γ2
9.52Single8X7ATreprostinil8X7A-I2-Treprostinil-Gs/β1/γ2
9.52Consensuscxcr2_onOrthosteric Ligand6LFM-CXCR2-Interleukin-8-Gi1/β1/γ2
9.52Consensusp2y1_on_gpOrthosteric Ligand7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/β1/γ2
9.09Single4QIMANTA XV4QIM-SMO-ANTA XV
9.09Single5NX2GLP-1 (Truncated)5NX2-GLP-1-GLP-1 (Truncated)
9.09Single6X1ADanuglipron6X1A-GLP-1-Danuglipron-Gs/β1/γ2
9.09Single6Z4VNTS8-136Z4V-NTS1-NTS8-13
9.09Single7FIHOrg435537FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/β1/γ2
9.09Single7S15PubChem 1346112237S15-GLP-1-PubChem 134611223
9.09Single7WQ3Galanin7WQ3-GAL1-Galanin-Gi1/β1/γ2
9.09Single8EJKTAK-8758EJK-FFA1-TAK-875-chim(NtGi1L-Gs-CtGq)/β1/γ2
9.09Single8IC0Interleukin-88IC0-CXCR1-Interleukin-8-Gi1/β1/γ2
9.09Single8T6JCDPPB8T6J-mGlu5; mGlu5-CDPPB
9.09Single9B9ZA1AKO9B9Z-CB1-A1AKO
9.09Consensuscxcr1_on_gpOrthosteric Ligand8IC0-CXCR1-Interleukin-8-Gi1/β1/γ2
9.09Consensusgal1_onOrthosteric Ligand7WQ3-GAL1-Galanin-Gi1/β1/γ2
9.09Consensusgal1_on_gpOrthosteric Ligand7WQ3-GAL1-Galanin-Gi1/β1/γ2
9.09Consensusgi_galaninOrthosteric Ligand7WQ3-GAL1-Galanin-Gi1/β1/γ2
8.70Single6Z4QSR142948A6Z4Q-NTS1-SR142948A
8.70Single6Z4SSR486926Z4S-NTS1-SR48692
8.70Single7VV0PAMP-127VV0-MRGPRX2-PAMP-12
8.70Single8EJCTAK-8758EJC-FFA1-TAK-875-chim(NtGi1L-Gs-CtGq)/β1/γ2
8.70Single8JGGBAM8-228JGG-MRGPRX1-BAM8-22-Gi1/β1/γ2
8.70Single8T6JCDPPB8T6J-mGlu5; mGlu5-CDPPB
8.70Single8XQPCholesterol8XQP-TAS2R14-Cholesterol-Aristolochic acid A-Gt3/β1/γ1
8.33Single3ZEVNeurotensin3ZEV-NTS1-Neurotensin
8.33Single4BV0Neurotensin4BV0-NTS1-Neurotensin
8.33Single5V56TC1145V56-SMO-TC114
8.33Single6Z8NSRI-98296Z8N-NTS1-SRI-9829
8.33Single7L0PNeurotensin7L0P-NTS1-Neurotensin-Gi1/β1/γ1
8.33Single7L0QNeurotensin7L0Q-NTS1-Neurotensin-Gi1/β1/γ1
8.33Single7XJLSpexin7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/β1/γ2
8.33Single8FMZNeurotensin/Neuromedin-N8FMZ-NTS1-Neurotensin/Neuromedin-N-chim(NtGi2L-Gs-CtGq)/β1/γ2
8.33Single8JGFBAM8-228JGF-MRGPRX1-BAM8-22-chim(NtGi1-Gs-CtGq)/β1/γ2
8.33Single8WJXADP8WJX-P2Y1-ADP-chim(Gs-CtGq)/β1/γ2
8.33Consensusneurotensin_onOrthosteric Ligandnts1_on
8.33Consensusnts1_onOrthosteric Ligand6OSA-NTS1-JMV449-Gi1/β1/γ2 7L0S-NTS1-Neurotensin-Gi1/β1/γ1
8.00Single4GRVNeurotensin-(8-13)4GRV-NTS1-Neurotensin-(8-13)
8.00Single6OSAJMV4496OSA-NTS1-JMV449-Gi1/β1/γ2
8.00Single6XOXOrforglipron6XOX-GLP-1-Orforglipron-chim(NtGi1-Gs)/β1/γ2
8.00Single6YVRNTS8-136YVR-NTS1-NTS8-13
8.00Single7WQ4Galanin7WQ4-GAL2-Galanin-chim(NtGi1-Gs-CtGq)/β1/γ2
8.00Single7XJKGalanin7XJK-GAL2-Galanin-chim(NtGi2L-Gs-CtGq)/β1/γ2
8.00Single8JPBNeurotensin-(8-13)8JPB-NTS1-Neurotensin-(8-13)-PubChem 118610427; GDP; Mg-Gq; GRK2
8.00Single8JPCNeurotensin-(8-13)8JPC-NTS1-Neurotensin-(8-13)-PubChem 118610427; GDP; Mg-Gq; GRK2
8.00Single8XQJJN2418XQJ-Apelin-JN241
8.00Consensusgi_neurotensinOrthosteric Ligand6OSA-NTS1-JMV449-Gi1/β1/γ2 7L0S-NTS1-Neurotensin-Gi1/β1/γ1
8.00Consensusneurotensin_on_gpOrthosteric Ligandnts1_on_gp
8.00Consensusnts1_on_gpOrthosteric Ligand6OSA-NTS1-JMV449-Gi1/β1/γ2 7L0S-NTS1-Neurotensin-Gi1/β1/γ1
7.69Single4RWSvMIP-II4RWS-CXCR4-vMIP-II
7.69Single6M1HMaxadilan6M1H-PAC1-Maxadilan-Gs/β1/γ2
7.69Single6UP7Neurotensin6UP7-NTS1-Neurotensin-Arrestin2
7.69Single7CX4Evatanepag7CX4-EP2-Evatanepag-Gs/β1/γ2
7.69Single8JPFNeurotensin8JPF-NTS1-Neurotensin-PubChem 118610427
7.69Single8XVUCXCL28XVU-CXCR2-CXCL2
7.69Single8XXHCXCL28XXH-CXCR2-CXCL2-Go/β1/γ2
7.41Single6KNMJN241-96KNM-Apelin-JN241-9
7.41Single6OS9JMV4496OS9-NTS1-JMV449-Gi1/β1/γ2
7.41Single7CX2PGE27CX2-EP2-PGE2-Gs/β1/γ2
7.41Single8XX6CXCL88XX6-CXCR2-CXCL8-Go/β1/γ2
7.14Single7CX3Taprenepag7CX3-EP2-Taprenepag-Gs/β1/γ2
7.14Single7RTBPeptide-197RTB-GLP-1-Peptide-19-Gs/β1/γ2
7.14Single8DWGProenkephalin-A8DWG-MRGPRX1-Proenkephalin-A-ML382-chim(NtGi2L-Gs-CtGq)/β1/γ2
7.14Single8JIQPeptide-158JIQ-Glucagon-Peptide-15-Gs/β1/γ2
7.14Single8XWNCXCL88XWN-CXCR2-CXCL8
6.90Single7SHEPI; PE7SHE-GPR158-PI; PE
6.67Single8Y63C20:0 Ceramide8Y63-FPR2-ALX-C20:0 Ceramide-Gi1/β1/γ2
6.25Single7TYHCalcitonin-17TYH-CT (AMY2)-Calcitonin-1-Gs/β1/γ2; RAMP2
6.25Single8JGBConorfamide-Tx28JGB-MRGPRX1-Conorfamide-Tx2-Gi1/β1/γ2
5.88Single7XKDBeta-Hydroxyandrosterone7XKD-ADGRG2-β-Hydroxyandrosterone-Gs/β1/γ2
5.88Single8HQMNPGLY8HQM-GPR132-NPGLY-Gi1/β1/γ2
5.88Single8HVINOX-6-78HVI-GPR132-NOX-6-7-Gi1/β1/γ2
5.88Single8SZICa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZI-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi3/β1/γ2
5.56Single7VDMSubstance-P7VDM-MRGPRX2-Substance-P-Gi1/β1/γ2
5.56Single7Y14Beta-Alanine7Y14-MRGPRD-β-Alanine
5.56Consensusp2y_offOrthosteric Ligandp2y1_off
5.26Single4XNWMRS25004XNW-P2Y1-MRS2500
5.26Single6PWCNeurotensin6PWC-NTS1-Neurotensin-Arrestin2
5.26Single7D77Hydrocortisone7D77-ADGRG3-Hydrocortisone-Go/β1/γ2
5.26Single7Y12Beta-Alanine7Y12-MRGPRD-β-Alanine-Gi1/β1/γ2
5.26Single8JRVGlucagon8JRV-Glucagon-Glucagon-Arrestin2
5.26Consensusp2y1_offOrthosteric Ligand4XNW-P2Y1-MRS2500
5.00Single6LI0C176LI0-GPR52-C17
5.00Single7S8NR-Zinc-35737S8N-MRGPRX2-R-Zinc-3573-chim(NtGi2L-Gs-CtGq)/β1/γ2
5.00Single7S8OR-Zinc-35737S8O-MRGPRX2-R-Zinc-3573-Gi1/β1/γ2
5.00Single7UL2SR486927UL2-NTS1-SR48692-Na
5.00Single7VDHC48/807VDH-MRGPRX2-C48/80-Gi1/β1/γ2
5.00Single7XKFBeta-Hydroxyandrosterone7XKF-ADGRG2-β-Hydroxyandrosterone-Gs/β1/γ2
5.00Single8FX5Xanomeline8FX5-M4-Xanomeline-Xanomeline-Gi1/β1/γ2
5.00Consensusgq_nucleotideOrthosteric Ligandgq_p2y
5.00Consensusgq_p2yOrthosteric Ligand7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/β1/γ2
5.00Consensusneurotensin_offOrthosteric Ligandnts1_off
5.00Consensusnts1_offOrthosteric Ligand7UL2-NTS1-SR48692-Na
4.76Single4BWBNeurotensin4BWB-NTS1-Neurotensin
4.76Single6WWZCCL206WWZ-CCR6-CCL20-Go/β1/γ2
4.76Single7VV5C48/807VV5-MRGPRX2-C48/80-Gi1/β1/γ2
4.76Single7VVOPTH7VVO-PTH1-PTH-Gs/β1/γ2
4.76Single8DWHPubChem 1390305318DWH-MRGPRX1-PubChem 139030531-chim(NtGi2L-Gs-CtGq)/β1/γ2
4.76Consensusccr6_onOrthosteric Ligand6WWZ-CCR6-CCL20-Go/β1/γ2
4.76Consensusccr6_on_gpOrthosteric Ligand6WWZ-CCR6-CCL20-Go/β1/γ2
4.76Consensusp2y1_onOrthosteric Ligand7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/β1/γ2
4.55Single7VV6C48/807VV6-MRGPRX2-C48/80
4.55Single8HJ5PubChem 1390305318HJ5-MRGPRX1-PubChem 139030531-chim(NtGi1-Gs-CtGq)/β1/γ2
4.55Single8IYXYL-3658IYX-GPR34-YL-365
4.55Single8JD6N-(3-chlorophenyl)pyridine-2-carboxamide8JD6-mGlu4; mGlu4-Phosphoserine-N-(3-chlorophenyl)pyridine-2-carboxamide-Gi3/β1/γ2
4.35Single6ORVTT-OAD26ORV-GLP-1-TT-OAD2-Gs/β1/γ2
4.35Single7SK8CXCL127SK8-ACKR3-CXCL12-CCX662
4.35Single8TH3AT118-H Nanobody8TH3-AT1-AT118-H Nanobody
4.35Single9IMATalquetamab9IMA-GPRC5D-Talquetamab
4.35Single9IVGGLP-1 (Truncated)9IVG-GLP-1-GLP-1 (Truncated)-chim(NtGi1-Gs)/β1/γ2
4.17Single4JKVTaladegib4JKV-SMO-Taladegib
4.17Single8TH4AT118-L Nanobody8TH4-AT1-Losartan-AT118-L Nanobody
4.17Single9EAHNanobody AT2099EAH-AT1-Olmesartan-Nanobody AT209
4.00Single5V57TC1145V57-SMO-TC114
4.00Single7SK7CXCL127SK7-ACKR3-CXCL12-CCX662
4.00Single8JD5BQI; HZE; PEF8JD5-mGlu2; mGlu4-Glutamate-BQI; HZE; PEF-Gi1/β1/γ2
4.00Single8XQTCholesterol8XQT-TAS2R14-Cholesterol-Cholesterol-Gi1/β1/γ1
4.00Single8XX7CXCL58XX7-CXCR2-CXCL5-Go/β1/γ2
3.85Single7SHEPI; PE7SHE-GPR158-PI; PE
3.85Single8DWCProenkephalin-A8DWC-MRGPRX1-Proenkephalin-A-chim(NtGi2L-Gs-CtGq)/β1/γ2
3.85Single8XWACXCL18XWA-CXCR2-CXCL1
3.85Single8XWMCXCL68XWM-CXCR2-CXCL6
3.85Single8XWSCXCL58XWS-CXCR2-CXCL5
3.85Single8XX3CXCL38XX3-CXCR2-CXCL3-Go/β1/γ2
3.70Single7SHFPI; PE7SHF-GPR158-PI; PE-B5; RGS7
3.70Single8XWFCXCL38XWF-CXCR2-CXCL3
3.70Single8XWVCXCL18XWV-CXCR2-CXCL1-Go/β1/γ2
3.57Single5TZYMK8666; PubChem 1270535975TZY-FFA1-MK8666; PubChem 127053597
3.45Single7VLACCL15(27-92)7VLA-CCR1-CCL15(27-92)-Gi1/β1/γ2
3.45Consensusccr1_onOrthosteric Ligand7VLA-CCR1-CCL15(27-92)-Gi1/β1/γ2
3.45Consensusccr1_on_gpOrthosteric Ligand7VLA-CCR1-CCL15(27-92)-Gi1/β1/γ2
3.33Single7SHFPI; PE7SHF-GPR158-PI; PE-B5; RGS7

Consensus Members
Id Members
8IRV 8IRV-D5-Rotigotine-chim(NtGi1-Gs)/β1/γ2
Net Summary
Imin 2.89
Number of Linked Nodes 858
Number of Links 1088
Number of Hubs 199
Number of Links mediated by Hubs 710
Number of Communities 20
Number of Nodes involved in Communities 282
Number of Links involved in Communities 431
Path Summary
Number Of Nodes in MetaPath 137
Number Of Links MetaPath 136
Number of Shortest Paths 1934112
Length Of Smallest Path 3
Average Path Length 27.4694
Length of Longest Path 54
Minimum Path Strength 1.225
Average Path Strength 6.29961
Maximum Path Strength 19.8
Minimum Path Correlation 0.7
Average Path Correlation 0.984146
Maximum Path Correlation 1
Minimum % Of Corr. Nodes 2.94118
Average % Of Corr. Nodes 47.0813
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 52.5919
Maximum Path Hubs % 100

Details about the values in these tables can be found in the corresponding documentation page .

This network is also present in following consensuses:
IdComponents
dopamine_on_gpd2_on_gp
d1_on_gp
d3_on_gp
d4_on_gp
d5_on_gp



You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download d5_on_gp.zip



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