Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg Int. Strength Num Of Links Community ConSurf
1R:R:F25 5.91503
2R:R:L37 3.8425404
3R:R:Y40 7.354507
4R:R:N51 6.995409
5R:R:V54 5.5175419
6R:R:F56 8.98413
7R:R:R61 4.115415
8R:R:D69 3.54518
9R:R:Y71 7.7125407
10R:R:L75 4.414519
11R:R:D79 7.008519
12R:R:W89 9.53333627
13R:R:M90 3.4975407
14R:R:Y92 5.9975426
15R:R:F111 11.02527
16R:R:Y112 11.25425
17R:R:F116 4.34833627
18R:R:F121 7.45517
19R:R:L127 2.73486
20R:R:Y130 8.28538
21R:R:V134 5.8475437
22R:R:W151 8.6406
23R:R:W152 5.438519
24R:R:H162 9.448524
25R:R:F163 5.6175474
26R:R:L201 4.6825406
27R:R:Y208 9.0325408
28R:R:F237 6.3075419
29R:R:W241 7.43518
30R:R:L242 5.09405
31R:R:Y244 7.146506
32R:R:H245 7.115408
33R:R:D251 5.7775405
34R:R:R271 6.885402
35R:R:E277 10.35406
36R:R:F281 8.3775427
37R:R:N287 5.804519
38R:R:Y291 5.295619
39R:R:V292 7.065417
40R:R:F293 3.86167617
41R:R:E301 4.98414
42L:L:?25 6.49429720
43L:L:H26 10.2471720
44L:L:V29 7.47520
45L:L:L47 8.455440
46L:L:L48 4.254500
47L:L:R61 8.685450
48L:L:I63 4.165400
49L:L:T67 4.224540
50L:L:F73 3.07440
51L:L:D76 6.65400
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
1L:L:F73 L:L:T67 53.28352.59YesYes400
2L:L:F73 R:R:T21 64.51392.59YesNo003
3R:R:P22 R:R:T21 65.90265.25NoNo033
4L:L:L72 R:R:P22 71.43613.28NoNo003
5L:L:I64 L:L:L72 75.49264.28NoNo000
6L:L:I34 L:L:I64 80.95817.36NoNo000
7L:L:I34 L:L:N54 89.11574.25NoNo000
8L:L:C58 L:L:N54 90.46799.45NoNo000
9L:L:C32 L:L:C58 45.72177.28NoNo000
10L:L:C32 L:L:S57 46.35823.44NoNo000
11L:L:K31 L:L:S57 47.64341.53NoNo000
12L:L:K31 R:R:Y92 1008.36NoYes006
13R:R:W89 R:R:Y92 47.91743.86YesYes276
14L:L:H26 R:R:W89 46.741911.64YesYes207
15L:L:H26 R:R:E277 91.031312.31YesYes006
16L:L:H27 R:R:E277 20.11498.62NoYes006
17L:L:H27 R:R:L273 19.506812.86NoNo005
18R:R:D251 R:R:L273 24.45775.43YesNo055
19R:R:D251 R:R:K254 17.43294.15YesNo053
20R:R:K254 R:R:S261 14.23326.12NoNo033
21R:R:E266 R:R:S261 12.76947.19NoNo033
22R:R:E266 R:R:F25 12.03443.5NoYes033
23L:L:C58 L:L:Q55 46.11761.53NoNo000
24L:L:Q55 R:R:Q172 46.76025.12NoNo003
25L:L:K31 R:R:Q172 51.85219.49NoNo003
26L:L:V29 R:R:Y92 48.61995.05YesYes206
27L:L:H26 L:L:V29 44.82339.69YesYes200
28L:L:H26 R:R:Y40 10.91885.44YesYes007
29R:R:E277 R:R:Y244 84.592313.47YesYes066
30R:R:H245 R:R:Y244 86.83473.27YesYes086
31R:R:H245 R:R:W241 70.70835.29YesYes088
32R:R:H283 R:R:W241 55.714711.64NoYes198
33R:R:H283 R:R:N287 56.87817.65NoYes199
34R:R:D79 R:R:N287 14.53276.73YesYes199
35R:R:D79 R:R:N51 14.122610.77YesYes099
36R:R:N51 R:R:P288 10.29759.77YesNo099
37R:R:N287 R:R:Y291 27.71223.49YesYes199
38R:R:F72 R:R:Y291 17.3065.16NoYes189
39R:R:F72 R:R:V292 18.12325.24NoYes187
40R:R:F293 R:R:V292 10.67923.93YesYes177
41R:R:F293 R:R:T57 12.5453.89YesNo176
42R:R:E301 R:R:T57 11.56542.82YesNo146
43R:R:L75 R:R:N287 18.93435.49YesYes199
44R:R:F121 R:R:L75 21.00322.44YesYes179
45R:R:F121 R:R:W151 13.55515.01YesYes076
46R:R:E124 R:R:W151 11.037618.54NoYes066
47R:R:F197 R:R:H245 15.666616.97NoYes098
48R:R:F197 R:R:F237 14.94384.29NoYes099
49R:R:F237 R:R:L201 27.66358.53YesYes096
50R:R:I204 R:R:L201 26.51642.85NoYes076
51R:R:A126 R:R:I204 25.74693.25NoNo097
52R:R:F237 R:R:W241 14.09419.02YesYes198
53R:R:A126 R:R:Y208 20.67936.67NoYes098
54R:R:V233 R:R:Y291 14.27996.31NoYes079
55R:R:V233 R:R:Y208 13.75313.79NoYes078
56R:R:L230 R:R:Y208 31.498616.41NoYes078
57R:R:I211 R:R:L230 25.0172.85NoNo087
58L:L:I43 L:L:L48 11.64674.28NoYes000
59L:L:L48 L:L:L65 21.71276.92YesNo000
60L:L:I63 L:L:L65 18.82472.85YesNo000
61L:L:I63 L:L:P77 14.59166.77YesNo000
62L:L:I43 L:L:W81 10.233615.27NoNo000
63R:R:I211 R:R:V215 22.41011.54NoNo088
64R:R:S218 R:R:V215 19.79513.23NoNo058
65R:R:K223 R:R:S218 14.50731.53NoNo1075
66R:R:G224 R:R:K223 13.22211.74NoNo067
67R:R:G224 R:R:R228 11.90151.5NoNo066
68R:R:R225 R:R:R228 10.57876.4NoNo076
69L:L:L48 L:L:T67 41.86522.95YesYes000
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


2D representation of the interactions of this orthosteric/allosteric ligand.


Links and nodes colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
L:L:S41 R:R:D15 8.83 0 No No 0 4 0 1
L:L:K42 R:R:D15 8.3 0 No No 0 4 0 1
R:R:A20 R:R:E18 3.02 0 No No 4 3 1 2
L:L:K38 R:R:D19 9.68 0 No No 0 4 0 1
R:R:P22 R:R:T21 5.25 0 No No 3 3 1 1
L:L:L72 R:R:P22 3.28 0 No No 0 3 0 1
L:L:C74 R:R:P22 5.65 0 No No 0 3 0 1
R:R:C23 R:R:F25 4.19 0 No Yes 8 3 2 1
L:L:I34 R:R:V24 3.07 0 No No 0 2 0 1
R:R:E266 R:R:F25 3.5 0 No Yes 3 3 2 1
R:R:F25 R:R:R267 5.34 0 Yes No 3 3 1 2
R:R:F25 R:R:K270 7.44 0 Yes No 3 4 1 2
L:L:T35 R:R:F25 9.08 0 No Yes 0 3 0 1
R:R:T36 R:R:Y40 8.74 0 No Yes 5 7 2 1
R:R:L37 R:R:M90 2.83 0 Yes Yes 4 7 2 2
R:R:L37 R:R:L93 5.54 0 Yes No 4 6 2 1
R:R:L86 R:R:Y40 9.38 0 No Yes 8 7 2 1
R:R:M90 R:R:Y40 5.99 0 Yes Yes 7 7 2 1
R:R:F281 R:R:Y40 7.22 2 Yes Yes 7 7 2 1
L:L:H26 R:R:Y40 5.44 2 Yes Yes 0 7 0 1
R:R:F111 R:R:F82 9.65 2 Yes No 7 7 1 2
R:R:F281 R:R:F82 12.86 2 Yes No 7 7 2 2
R:R:T85 R:R:W89 4.85 2 No Yes 7 7 2 1
R:R:L107 R:R:T85 2.95 2 No No 5 7 2 2
R:R:W89 R:R:Y92 3.86 2 Yes Yes 7 6 1 1
R:R:L107 R:R:W89 19.36 2 No Yes 5 7 2 1
R:R:F111 R:R:W89 4.01 2 Yes Yes 7 7 1 1
L:L:H26 R:R:W89 11.64 2 Yes Yes 0 7 0 1
L:L:V29 R:R:W89 13.48 2 Yes Yes 0 7 0 1
R:R:C173 R:R:Y92 6.72 0 No Yes 9 6 1 1
L:L:V29 R:R:Y92 5.05 2 Yes Yes 0 6 0 1
L:L:K31 R:R:Y92 8.36 0 No Yes 0 6 0 1
L:L:V29 R:R:L93 5.96 2 Yes No 0 6 0 1
R:R:C104 R:R:C173 7.28 0 No No 9 9 2 1
R:R:T108 R:R:V166 12.69 2 No No 6 5 1 1
L:L:?25 R:R:T108 6.28 2 Yes No 0 6 0 1
R:R:F111 R:R:Y112 12.38 2 Yes Yes 7 5 1 1
R:R:F111 R:R:F281 6.43 2 Yes Yes 7 7 1 2
L:L:H26 R:R:F111 22.63 2 Yes Yes 0 7 0 1
R:R:F116 R:R:Y112 4.13 2 Yes Yes 7 5 2 1
R:R:H162 R:R:Y112 18.51 2 Yes Yes 4 5 2 1
L:L:?25 R:R:Y112 9.98 2 Yes Yes 0 5 0 1
R:R:F116 R:R:H162 4.53 2 Yes Yes 7 4 2 2
R:R:T175 R:R:V165 4.76 0 No No 5 5 1 2
L:L:?25 R:R:V166 11.1 2 Yes No 0 5 0 1
R:R:K169 R:R:M174 2.88 0 No No 3 4 1 1
L:L:K31 R:R:Q172 9.49 0 No No 0 3 0 1
L:L:Q55 R:R:Q172 5.12 0 No No 0 3 0 1
L:L:A56 R:R:Q172 4.55 0 No No 0 3 0 1
L:L:?25 R:R:C173 3.38 2 Yes No 0 9 0 1
R:R:T175 R:R:Y177 12.48 0 No No 5 5 1 2
L:L:?25 R:R:T175 4.71 2 Yes No 0 5 0 1
R:R:D176 R:R:D178 3.99 5 No No 4 6 1 1
R:R:D176 R:R:Y179 14.94 5 No No 4 1 1 1
L:L:R61 R:R:D176 10.72 5 Yes No 0 4 0 1
L:L:K60 R:R:D178 6.91 0 No No 0 6 0 1
L:L:R61 R:R:D178 7.15 5 Yes No 0 6 0 1
L:L:R61 R:R:Y179 15.43 5 Yes No 0 1 0 1
R:R:E277 R:R:Y244 13.47 0 Yes Yes 6 6 1 2
R:R:L273 R:R:T247 4.42 0 No No 5 5 1 2
R:R:D251 R:R:L273 5.43 0 Yes No 5 5 2 1
L:L:H27 R:R:L273 12.86 0 No No 0 5 0 1
R:R:E277 R:R:F281 7 0 Yes Yes 6 7 1 2
L:L:H26 R:R:E277 12.31 2 Yes Yes 0 6 0 1
L:L:H27 R:R:E277 8.62 0 No Yes 0 6 0 1
L:L:F73 R:R:T21 2.59 4 Yes No 0 3 0 1
L:L:G59 R:R:M174 1.75 0 No No 0 4 0 1
L:L:T40 R:R:A20 1.68 0 No No 0 4 0 1
L:L:A33 R:R:T26 1.68 0 No No 0 4 0 1
L:L:K38 R:R:A20 1.61 0 No No 0 4 0 1
L:L:A56 R:R:K169 1.61 0 No No 0 3 0 1
R:R:T26 R:R:V24 1.59 0 No No 4 2 1 1
L:L:A33 R:R:L29 1.58 0 No No 0 3 0 1
L:L:A56 R:R:D170 1.54 0 No No 0 1 0 1
R:R:M174 R:R:T167 1.51 0 No No 4 4 1 2
R:R:N30 R:R:T26 1.46 0 No No 4 4 2 1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

ShowSimilarityNetwork TypeNameLigandDescription
77.27Single4XT3Fractalkine4XT3-US28-Fractalkine
75.00Single7RKMFractalkine7RKM-US28-Fractalkine-Gi1/&β;1/&γ;2
65.00Single7RKFFractalkine7RKF-US28-Fractalkine-GDP-chim(NtGi1-G11)/&β;1/&γ;2
57.14Single7RKNFractalkine7RKN-US28-Fractalkine-Gi1/&β;1/&γ;2
55.56Single5NDDAZ8838; Na5NDD-PAR2-AZ8838; Na
51.85Consensusgi_chemokineOrthosteric Ligand7VL9-CCR1-CCL15(26-92)-Gi1/&β;1/&γ;2 7XA3-CCR2-CCL2-Gi1/&β;1/&γ;2 7O7F-CCR5-(6P4)CCL5-Gi1/&β;1/&γ;1 7F1Q-CCR5-MIP-1a-Gi1/&β;1/&γ;2 7XBX-CX3CR1-CX3CL1-Gi1/&β;1/&γ;2 8IC0-CXCR1-Interleukin-8-Gi1/&β;1/&γ;2 6LFM-CXCR2-Interleukin-8-Gi1/&β;1/&γ;2 8U1U-CCR8-CCL1-Gi1/&β;1/&γ;2
50.00Single7XA3CCL27XA3-CCR2-CCL2-Gi1/&β;1/&γ;2
50.00Single8IYWGSK2560738IYW-HCA2-GSK256073-Go/&β;1/&γ;2
50.00Consensusccr2_onOrthosteric Ligand7XA3-CCR2-CCL2-Gi1/&β;1/&γ;2
50.00Consensusprotein_onOrthosteric Ligandccr_on chemokine_on gphr_on chemerin_on
47.83Single8U4OCXCL128U4O-CXCR4-CXCL12-Cholesterol-Gi1/&β;1/&γ;2
47.62Consensusdp2_offOrthosteric Ligand6D27-DP2-CAY10471 6D26-DP2-Fevipiprant
47.62Consensusdp_offOrthosteric Liganddp2_off
47.37Consensusgi_hcaOrthosteric Ligand8H2G-HCA2-Niacin-Gi1/&β;1/&γ;2 8IHJ-HCA3-Acifran-Gi1/&β;1/&γ;2 8IHI-HCA2-Acifran-Gi1/&β;1/&γ;2 8IHB-HCA2-GSK256073-Gi1/&β;1/&γ;2 8IHH-HCA2-LUF6283-Gi1/&β;1/&γ;2 8IHF-HCA2-MK6892-Gi1/&β;1/&γ;2 8JIM-HCA2-MMF-Gi1/&β;1/&γ;2 8IJB-HCA2-Acipimox-Gi1/&β;1/&γ;2 8IJD-HCA2-MK6892-Gi1/&β;1/&γ;2
47.37Consensusgi_hcarOrthosteric Ligandgi_hca
47.37Consensushca2_onOrthosteric Ligand8H2G-HCA2-Niacin-Gi1/&β;1/&γ;2 8IHI-HCA2-Acifran-Gi1/&β;1/&γ;2 8IHH-HCA2-LUF6283-Gi1/&β;1/&γ;2 8IHF-HCA2-MK6892-Gi1/&β;1/&γ;2 8JHY-HCA2-Compound 9n-Gi1/&β;1/&γ;2 8IHB-HCA2-GSK256073-Gi1/&β;1/&γ;2 8JIM-HCA2-MMF-Gi1/&β;1/&γ;2 8IJB-HCA2-Acipimox-Gi1/&β;1/&γ;2 8IJD-HCA2-MK6892-Gi1/&β;1/&γ;2 8J6J-HCA2-GSK256073-Gi1/&β;1/&γ;2
47.06Single3OE9IT1t3OE9-CXCR4-IT1t
46.43Consensusgs_peptideOrthosteric Ligandgs_cck gs_motilin gs_neuromedin gs_orexin gs_sst gs_tachykinin gs_trh gs_vasopressin-ot gs_bombesin gs_bradykinin gs_compl-peptide gs_endothelin gs_galanin gs_ghrelin gs_melanocortin
46.43Consensuspeptide_onOrthosteric Ligandopioid_on angiotensin_on bombesin_on cck_on endothelin_on ghrelin_on npy_on nts_on orexin_on vasopressin-ot_on tachykinin_on sst_on relaxin_on trh_on nmur_on motilin_on melanocortin_on galanin_on fpr-alx_on compl-peptide_on bradykinin_on apelin_on
44.83Consensusgi_peptideOrthosteric Ligandgi_opioid gi_endothelin gi_formylpeptide gi_galanin gi_ghrelin gi_neuromedin gi_neurotensin gi_relaxin gi_neuropeptide gi_somatostatin gi_apelin gi_compl-peptide gi_cck
44.44Single3ODUIT1t3ODU-CXCR4-IT1t
44.44Single5UIW5P7-CCL55UIW-CCR5-5P7-CCL5
44.44Consensusccr5_offOrthosteric Ligand5UIW-CCR5-5P7-CCL5
44.00Single7O7F(6P4)CCL57O7F-CCR5-(6P4)CCL5-Gi1/&β;1/&γ;1
43.48Consensuschemokine_onOrthosteric Ligandcxcr_on cx3cr_on
42.86Single7M8W15r-Methyl-Prostaglandin D27M8W-DP2-15r-Methyl-Prostaglandin D2-Na
42.86Single8IHHLUF62838IHH-HCA2-LUF6283-Gi1/&β;1/&γ;2
42.86Consensusccr8_onOrthosteric Ligand8U1U-CCR8-CCL1-Gi1/&β;1/&γ;2
42.86Consensusccr_onOrthosteric Ligandccr5_on ccr6_on ccr1_on ccr2_on ccr8_on
42.31Single7F6GSAR1-AngII7F6G-AT1-SAR1-AngII-Gq/&β;1/&γ;2
42.31Single8IA2C5a anaphylatoxin8IA2-C5a1-C5a anaphylatoxin-Go/&β;1/&γ;2
42.31Consensusccr1_onOrthosteric Ligand7VL9-CCR1-CCL15(26-92)-Gi1/&β;1/&γ;2
42.31Consensusgq_angiotensinOrthosteric Ligand7F6G-AT1-SAR1-AngII-Gq/&β;1/&γ;2
42.11Single7XXH2MeSADP7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/&β;1/&γ;2
42.11Single8JIMMMF8JIM-HCA2-MMF-Gi1/&β;1/&γ;2
41.67Consensusgi_opioidOrthosteric Ligand8EF6-μ-Morphine-Gi1/&β;1/&γ;2 8F7Q-μ-Beta-endorphin-Gi1/&β;1/&γ;2 7U2K-μ-C6-guano-Gi1/&β;1/&γ;2 8EFQ-μ-Damgo-Gi1/&β;1/&γ;2 8F7S-δ-Deltorphin-Gi1/&β;1/&γ;2 8F7W-κ-Dynorphin-Gi1/&β;1/&γ;2 8F7R-μ-Endomorphin-Gi1/&β;1/&γ;2 8EF5-μ-Fentanyl-Gi1/&β;1/&γ;2 7SCG-μ-FH210-Gi1/&β;1/&γ;2 7T2H-μ-Lofentanil-Gi1/&β;1/&γ;2 7T2G-μ-Mitragynine pseudoindoxyl-Gi1/&β;1/&γ;2 8DZP-κ-momSalB-Gi1/&β;1/&γ;2 8F7X-NOP-Nociceptin-Gi1/&β;1/&γ;2 8EFB-μ-Oliceridine-Gi1/&β;1/&γ;2 8FEG-κ-PRD_002517-Gi1/&β;1/&γ;2 7U2L-μ-PubChem 163201242-Gi1/&β;1/&γ;2 8EFO-μ-PZM21-Gi1/&β;1/&γ;2 8EFL-μ-SR17018-Gi1/&β;1/&γ;2
41.38Consensusgq_peptideOrthosteric Ligandgq_cck gq_angiotensin gq_bombesin gq_bradykinin
41.18Single3OE6IT1t3OE6-CXCR4-IT1t
40.91Single6C1RPMX536C1R-C5a1-PMX53-Avacopan; Na
40.91Single7W0NElabela7W0N-Apelin-Elabela-Gi1/&β;1/&γ;2
40.91Single8IBUErythromycin A8IBU-Motilin-Erythromycin A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
40.74Single7VL9CCL15(26-92)7VL9-CCR1-CCL15(26-92)-Gi1/&β;1/&γ;2
40.74Single7Y64C5a anaphylatoxin7Y64-C5a1-C5a anaphylatoxin-Gi1/&β;1/&γ;2
40.74Single8E3ZVIP8E3Z-VPAC1-VIP-Gs/&β;1/&γ;2
40.00Single4YAYZD-71554YAY-AT1-ZD-7155
40.00Single5ZKPForopafant (SR27417)5ZKP-PAF-Foropafant (SR27417)
40.00Single6IGKEndothelin-36IGK-ETB-Endothelin-3
40.00Single6Z10PubChem 1545855546Z10-Succinate-PubChem 154585554
40.00Single7V3ZPubMed 1048957V3Z-CB1-PubMed 104895
40.00Single7W0NElabela7W0N-Apelin-Elabela-Gi1/&β;1/&γ;2
40.00Single8I7WGSK2560738I7W-HCA2-GSK256073-Gi1/&β;1/&γ;2
40.00Single8JIINiacin8JII-HCA2-Niacin-Compound 9n-Gi1/&β;1/&γ;2
40.00Single8K5DGSK2560738K5D-HCA2-GSK256073
40.00Consensusalpha1_offOrthosteric Ligandalpha1a_off alpha1b_off
40.00Consensuscx3cr_onOrthosteric Ligandcx3cr1_on
40.00Consensusgi_cckOrthosteric Ligand7EZH-CCKA-Cholecystokinin-8-Gi1/&β;1/&γ;2 7F8V-CCKB-Gastrin-17-Gi2/&β;1/&γ;2
40.00Consensuslipid_offOrthosteric Ligandcannabinoid_off leuko_off lpl_off paf_off prostanoid_off
40.00Consensuspaf_offOrthosteric Ligand5ZKQ-PAF-ABT-491 5ZKP-PAF-Foropafant (SR27417)
39.29Single8HAOPTH8HAO-PTH1-PTH-chim(NtGi1-Gs)/&β;1/&γ;2
39.29Consensusccr5_onOrthosteric Ligand7O7F-CCR5-(6P4)CCL5-Gi1/&β;1/&γ;1 7F1Q-CCR5-MIP-1a-Gi1/&β;1/&γ;2
39.29Consensusgi_compl-peptideOrthosteric Ligand8HK5-C5a1-Complement C5-Gi1/&β;1/&γ;2 8IA8-C3aB-E7 peptide-Gi1/&β;1/&γ;2 7Y66-C5a1-BM213-Gi1/&β;1/&γ;2 7Y67-C5a1-C089 peptide-Gi1/&β;1/&γ;2 8HK2-C3aB-C3a anaphylatoxin-Gi1/&β;1/&γ;2 7Y64-C5a1-C5a anaphylatoxin-Gi1/&β;1/&γ;2 7Y65-C5a1-C5a peptide-Gi1/&β;1/&γ;2
39.13Single5UNGPubChem 157800525UNG-AT2-PubChem 15780052
39.13Single7X8RBOC57X8R-GLP-1-BOC5-Gs/&β;1/&γ;2
39.13Single7Y65C5a peptide7Y65-C5a1-C5a peptide-Gi1/&β;1/&γ;2
39.13Consensusgi_class-aOrthosteric Ligandgi_amine gi_lipid gi_melatonin gi_peptide gi_protein gi_nucleotide gi_hcar
38.46Single6VN7PACAP6VN7-VPAC1-PACAP-Gs/&β;1/&γ;2
38.46Consensusangiotensin_onOrthosteric Ligandat1_on
38.46Consensusat1_onOrthosteric Ligand7F6G-AT1-SAR1-AngII-Gq/&β;1/&γ;2
38.46Consensuscx3cr1_onOrthosteric Ligand7XBX-CX3CR1-CX3CL1-Gi1/&β;1/&γ;2
38.46Consensusopioid_onOrthosteric Ligandkop_on mop_on nop_on dop_on
38.10Single6D26Fevipiprant6D26-DP2-Fevipiprant
38.10Single7BB7Acyclovir triphosphate7BB7-V2-Acyclovir triphosphate-Gs/&β;1/&γ;2
38.10Single7EO2FTY720-P7EO2-S1P1-FTY720-P-Gi1/&β;1/&γ;2
38.10Single7TD3S1P7TD3-S1P1-S1P-Gi1/&β;1/&γ;2
38.10Single8IHJAcifran8IHJ-HCA3-Acifran-Gi1/&β;1/&γ;2
38.10Single8J6JGSK2560738J6J-HCA2-GSK256073-Gi1/&β;1/&γ;2
38.10Consensuscb2_onOrthosteric Ligand8GUS-CB2-HU-308-Gi1/&β;1/&γ;2 8GUT-CB2-LEI-102-Gi1/&β;1/&γ;2 8GUQ-CB2-Olorinab-Gi1/&β;1/&γ;2 8GUR-CB2-PubChem 104895-Gi1/&β;1/&γ;2 6KPF-CB2-PubChem 145915889-Gi1/&β;1/&γ;2 6PT0-CB2-WIN 55212-2-Gi1/&β;1/&γ;2
37.93Single7YOONeuropeptide Y7YOO-Y2-Neuropeptide Y-Gi1/&β;1/&γ;2
37.93Consensusgi_proteinOrthosteric Ligandgi_chemokine gi_chemerin
37.50Single6C1QPMX536C1Q-C5a1-PMX53-NDT9513727
37.50Single8F7REndomorphin8F7R-μ-Endomorphin-Gi1/&β;1/&γ;2
37.50Single8U1UCCL18U1U-CCR8-CCL1-Gi1/&β;1/&γ;2
37.50Consensusc3a_onOrthosteric Ligand8HK2-C3aB-C3a anaphylatoxin-Gi1/&β;1/&γ;2 8IA8-C3aB-E7 peptide-Gi1/&β;1/&γ;2 8J6D-C3aB-EP141-Go/&β;1/&γ;2 8I95-C3aB-EP54-Go/&β;1/&γ;2
37.50Consensusdop_onOrthosteric Ligand8F7S-δ-Deltorphin-Gi1/&β;1/&γ;2
37.50Consensusgo_compl-peptideOrthosteric Ligand8I95-C3aB-EP54-Go/&β;1/&γ;2 8IA2-C5a1-C5a anaphylatoxin-Go/&β;1/&γ;2 8I9L-C3aB-C3a anaphylatoxin-Go/&β;1/&γ;2 8J6D-C3aB-EP141-Go/&β;1/&γ;2
37.50Consensuslipid_onOrthosteric Ligandcannabinoid_on ffa_on gpr119_on leuko_on lpl_on prostanoid_on
37.50Consensuslpl_offOrthosteric Ligands1p_off lpa_off
37.04Single6M1IPACAP6M1I-PAC1-PACAP-Gs/&β;1/&γ;2
37.04Single6WI9Secretin6WI9-Secretin-Secretin-Gs/&β;1/&γ;2
37.04Single7FIMTirzepatide7FIM-GLP-1-Tirzepatide-Gs/&β;1/&γ;2
37.04Single7YONPeptide YY(3-36)7YON-Y2-Peptide YY(3-36)-Gi1/&β;1/&γ;2
37.04Single8XZJWN3538XZJ-Apelin-WN353-Gi1/&β;1/&γ;2
37.04Consensuscompl-peptide_onOrthosteric Ligandc5a1_on c3a_on
36.84Single5ZKQABT-4915ZKQ-PAF-ABT-491
36.84Single7WF7S1P7WF7-S1P1-S1P-Gi1/&β;1/&γ;2
36.84Consensusm2_on_alloOther Ligand7T94-M2-Acetylcholine-PubChem 57664406-chim(NtGi1-Go)/&β;1/&γ;2 6OIK-M2-Iperoxo-LY2119620-chim(NtGi1-Go)/&β;1/&γ;2
36.67Single6NBHLong-acting PTH analog6NBH-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2
36.67Single6WZGSecretin6WZG-Secretin-Secretin-Gs/&β;1/&γ;2
36.67Single7D68GLP-27D68-GLP-2-GLP-2-Gs/&β;1/&γ;2
36.36Single7F1TMIP-1a7F1T-CCR5-MIP-1a
36.36Single7TUYGSK682753A7TUY-GPR183-GSK682753A
36.36Single7XBDGalanin7XBD-GAL2-Galanin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
36.36Single8IHBGSK2560738IHB-HCA2-GSK256073-Gi1/&β;1/&γ;2
36.36Consensuscck_onOrthosteric Ligandccka_on cckb_on
36.36Consensusccka_onOrthosteric Ligand7EZH-CCKA-Cholecystokinin-8-Gi1/&β;1/&γ;2 7XOV-CCKA-SR146131-Gs/&β;1/&γ;2
36.36Consensusclass-a_offOrthosteric Ligandsensory_off amine_off lipid_off nucleotide_off peptide_off protein_off hcar_off
36.36Consensusgs_vip-pacapOrthosteric Ligand8E3Y-VPAC1-PACAP27-Gs/&β;1/&γ;2 7VQX-VPAC1-PACAP27-Gs/&β;1/&γ;2 8E3Z-VPAC1-VIP-Gs/&β;1/&γ;2 6M1I-PAC1-PACAP-Gs/&β;1/&γ;2 6VN7-VPAC1-PACAP-Gs/&β;1/&γ;2
36.00Single5UNFPubChem 157800525UNF-AT2-PubChem 15780052
36.00Single7W0PElabela7W0P-Apelin-Elabela-Gi1/&β;1/&γ;2
36.00Single8JZZC5a-desArg8JZZ-C5a1-C5a-desArg-Go/&β;1/&γ;2
36.00Consensusapelin_onOrthosteric Ligand7W0P-Apelin-Elabela-Gi1/&β;1/&γ;2 7W0M-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
36.00Consensusgi_relaxinOrthosteric Ligand7YK7-RXFP4-DC591053-Gi2/&β;1/&γ;2 7YJ4-RXFP4-INSL5-Gi2/&β;1/&γ;2 7YK6-RXFP4-PubChem 138319674-Gi2/&β;1/&γ;2
36.00Consensusprotein_offOrthosteric Ligandccr_off chemokine_off gnrh_off
35.71Single7F9YGhrelin-287F9Y-Ghrelin-Ghrelin-28-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
35.71Single7V9MSomatoliberin7V9M-GHRH (SV1)-Somatoliberin-Gs/&β;1/&γ;2
35.71Single8E3YPACAP278E3Y-VPAC1-PACAP27-Gs/&β;1/&γ;2
35.71Single8HK5Complement C58HK5-C5a1-Complement C5-Gi1/&β;1/&γ;2
35.71Consensusc5a1_onOrthosteric Ligand7Y65-C5a1-C5a peptide-Gi1/&β;1/&γ;2 8HK5-C5a1-Complement C5-Gi1/&β;1/&γ;2 7Y66-C5a1-BM213-Gi1/&β;1/&γ;2 7Y67-C5a1-C089 peptide-Gi1/&β;1/&γ;2 7Y64-C5a1-C5a anaphylatoxin-Gi1/&β;1/&γ;2
35.71Consensusgs_ghrelinOrthosteric Ligand7F9Y-Ghrelin-Ghrelin-28-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
35.71Consensusmc1_onOrthosteric Ligand7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/&β;1/&γ;2 7F4D-MC1-Alpha-MSH-chim(NtGi1-Gs)/&β;1/&γ;2 7F4I-MC1-SHU9119-chim(NtGi1-Gs)/&β;1/&γ;2
35.48Single5GLHEndothelin-15GLH-ETB-Endothelin-1
35.00Single3V2YPubChem 518926453V2Y-S1P1-PubChem 51892645
35.00Single6PT0WIN 55212-26PT0-CB2-WIN 55212-2-Gi1/&β;1/&γ;2
35.00Single7F61PF-036547467F61-H3-PF-03654746-Cholesterol
35.00Single7TRQVU04671547TRQ-M4-Iperoxo-VU0467154-Gi1/&β;1/&γ;2
35.00Single7XJJGalanin7XJJ-GAL1-Galanin-Go/&β;1/&γ;2
35.00Single7YK6PubChem 1383196747YK6-RXFP4-PubChem 138319674-Gi2/&β;1/&γ;2
35.00Single8GURPubChem 1048958GUR-CB2-PubChem 104895-Gi1/&β;1/&γ;2
35.00Single8J6PNiacin8J6P-HCA2-Niacin-Compound 9n-Gi1/&β;1/&γ;2
35.00Single8JERAcipimox8JER-HCA2-Acipimox-Go/&β;1/&γ;2
35.00Single8JLQFenoldopam8JLQ-TA1-Fenoldopam-Gs/&β;1/&γ;2
35.00Single8K5CAcipimox8K5C-HCA2-Acipimox
35.00Consensusat1_offOrthosteric Ligand4YAY-AT1-ZD-7155 4ZUD-AT1-Olmesartan
35.00Consensusgo_galaninOrthosteric Ligand7XJJ-GAL1-Galanin-Go/&β;1/&γ;2
35.00Consensush3_on_alloOrthosteric Ligand7F61-H3-PF-03654746-Cholesterol
35.00Consensushca_onOrthosteric Ligandhca2_on hca3_on
35.00Consensushcar_onOrthosteric Ligandhca_on
35.00Consensuss1p1_offOrthosteric Ligand3V2Y-S1P1-PubChem 51892645
35.00Consensuss1p_offOrthosteric Ligands1p1_off
34.78Single6KPGAM8416KPG-CB1-AM841-Gi1/&β;1/&γ;2
34.78Single6OS0Angiotensinogen6OS0-AT1-Angiotensinogen
34.78Single6OS2TRV0266OS2-AT1-TRV026
34.78Single7EW2Fingolimod7EW2-S1P3-Fingolimod-Gi1/&β;1/&γ;2
34.78Single8I95EP548I95-C3aB-EP54-Go/&β;1/&γ;2
34.78Single8IA8E7 peptide8IA8-C3aB-E7 peptide-Gi1/&β;1/&γ;2
34.78Consensuscannabinoid_onOrthosteric Ligandcb1_on cb2_on
34.78Consensuscb1_onOrthosteric Ligand8GHV-CB1-PubChem 145964903-Gi1/&β;1/&γ;2 6KPG-CB1-AM841-Gi1/&β;1/&γ;2 6N4B-CB1-MDMB-Fubinaca-Gi1/&β;1/&γ;2
34.78Consensuschemokine_offOrthosteric Ligandcxcr_off
34.78Consensuscxcr4_offOrthosteric Ligand4RWS-CXCR4-vMIP-II
34.78Consensuscxcr_offOrthosteric Ligandcxcr4_off
34.78Consensusgalanin_onOrthosteric Ligandgal2_on gal1_on
34.78Consensusgi_cannabinoidOrthosteric Ligand8GUS-CB2-HU-308-Gi1/&β;1/&γ;2 8GUT-CB2-LEI-102-Gi1/&β;1/&γ;2 8GUQ-CB2-Olorinab-Gi1/&β;1/&γ;2 8GUR-CB2-PubChem 104895-Gi1/&β;1/&γ;2 6KPF-CB2-PubChem 145915889-Gi1/&β;1/&γ;2 6PT0-CB2-WIN 55212-2-Gi1/&β;1/&γ;2 6KPG-CB1-AM841-Gi1/&β;1/&γ;2 6N4B-CB1-MDMB-Fubinaca-Gi1/&β;1/&γ;2 8GHV-CB1-PubChem 145964903-Gi1/&β;1/&γ;2
34.78Consensusmop_onOrthosteric Ligand8F7Q-μ-Beta-endorphin-Gi1/&β;1/&γ;2 8EFQ-μ-Damgo-Gi1/&β;1/&γ;2 8F7R-μ-Endomorphin-Gi1/&β;1/&γ;2 8EF5-μ-Fentanyl-Gi1/&β;1/&γ;2 8EF6-μ-Morphine-Gi1/&β;1/&γ;2 8EFB-μ-Oliceridine-Gi1/&β;1/&γ;2 8EFO-μ-PZM21-Gi1/&β;1/&γ;2 8EFL-μ-SR17018-Gi1/&β;1/&γ;2
34.62Single6DO1Angiotensin-Like peptide S1I86DO1-AT1-Angiotensin-Like peptide S1I8
34.62Single6WHCGlu16 analog of GCG6WHC-Glucagon-Glu16 analog of GCG-Gs/&β;1/&γ;2
34.62Single7EZKCholecystokinin-87EZK-CCKA-Cholecystokinin-8-chim(NtGi1-Gs)/&β;1/&γ;2
34.62Single7F1QMIP-1a7F1Q-CCR5-MIP-1a-Gi1/&β;1/&γ;2
34.62Single7SK5CXCL127SK5-ACKR3-CXCL12
34.62Single7XBXCX3CL17XBX-CX3CR1-CX3CL1-Gi1/&β;1/&γ;2
34.62Single8F7SDeltorphin8F7S-δ-Deltorphin-Gi1/&β;1/&γ;2
34.62Consensusgi_lplOrthosteric Ligand7EW3-S1P3-S1P-Gi1/&β;1/&γ;2 7TD4-S1P1-Siponimod-Gi1/&β;1/&γ;2 7VIF-S1P1-(S)-FTY720-P-Gi1/&β;1/&γ;2 7EO4-S1P1-BAF312-Gi1/&β;1/&γ;2 7VIG-S1P1-CBP-307-Gi1/&β;1/&γ;2 7EVZ-S1P1-Cenerimod-Gi1/&β;1/&γ;2 7EW4-S1P3-CYM5541-Gi1/&β;1/&γ;2 7EW2-S1P3-Fingolimod-Gi1/&β;1/&γ;2 7TD0-LPA1-LPA-Gi1/&β;1/&γ;2 7YU3-LPA1-ONO-0740556-Gi1/&β;1/&γ;2 7EW0-S1P1-Ozanimod-Gi1/&β;1/&γ;2 7EW7-S1P1-PubChem 4077460-Gi1/&β;1/&γ;2
34.48Single6FJ3PTH6FJ3-PTH1-PTH
34.48Single7F8VGastrin-177F8V-CCKB-Gastrin-17-Gi2/&β;1/&γ;2
34.48Single7RGPTirzepatide7RGP-GLP-1-Tirzepatide-chim(NtGi1-Gs)/&β;1/&γ;2
34.48Single8E3XPACAP278E3X-PAC1-PACAP27-Gs/&β;1/&γ;2
34.48Consensusnpy2_onOrthosteric Ligand7YOO-Y2-Neuropeptide Y-Gi1/&β;1/&γ;2 7YON-Y2-Peptide YY(3-36)-Gi1/&β;1/&γ;2
34.38Single6WPWGlucagon derivative ZP37806WPW-Glucagon-Glucagon derivative ZP3780-Gs/&β;1/&γ;2
34.38Consensusglp_onOrthosteric Ligandglp1_on glp2_on
34.38Consensusmelanocortin_onOrthosteric Ligandmc2_on mc1_on mc3_on mc4_on mc5_on
33.33Single3OE0CVX153OE0-CXCR4-CVX15
33.33Single3OE8IT1t3OE8-CXCR4-IT1t
33.33Single4RWSvMIP-II4RWS-CXCR4-vMIP-II
33.33Single4ZUDOlmesartan4ZUD-AT1-Olmesartan
33.33Single6D27CAY104716D27-DP2-CAY10471
33.33Single6LRYSarafotoxin-B6LRY-ETB-Sarafotoxin-B
33.33Single6OIKLY21196206OIK-M2-Iperoxo-LY2119620-chim(NtGi1-Go)/&β;1/&γ;2
33.33Single7EZHCholecystokinin-87EZH-CCKA-Cholecystokinin-8-Gi1/&β;1/&γ;2
33.33Single7F16TIP397F16-PTH2-TIP39-Gs/&β;1/&γ;2
33.33Single7F4HAfamelanotide7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/&β;1/&γ;2
33.33Single7LCIDanuglipron7LCI-GLP-1-Danuglipron-Gs/&β;1/&γ;2
33.33Single7LLLExendin-47LLL-GLP-1-Exendin-4-Gs/&β;1/&γ;2
33.33Single7MBXCholecystokinin-87MBX-CCKA-Cholecystokinin-8-Gs/&β;1/&γ;1
33.33Single7NA8PubChem 1780247NA8-Ghrelin-PubChem 178024-Gi1/&β;1/&γ;2
33.33Single7VIES1P7VIE-S1P1-S1P-Gi1/&β;1/&γ;2
33.33Single7WQ3Galanin7WQ3-GAL1-Galanin-Gi1/&β;1/&γ;2
33.33Single7XK8Neuromedin-U-257XK8-NMUR2-Neuromedin-U-25-Gi1/&β;1/&γ;2
33.33Single7YACPaltusotine7YAC-SST2-Paltusotine-Gi1/&β;1/&γ;2
33.33Single8FU6Glucagon derivative ZP37808FU6-Glucagon-Glucagon derivative ZP3780-Gs/&β;1/&γ;2
33.33Single8HN1Toxin AdTx18HN1-Alpha1A-Toxin AdTx1
33.33Single8I7VAcipimox8I7V-HCA2-Acipimox-Gi1/&β;1/&γ;2
33.33Single8WRZ8D08WRZ-CB1-8D0-Arrestin1
33.33Consensusalpha_offOrthosteric Ligandalpha1_off alpha2_off
33.33Consensusc5a1_off_ortoalloOrthosteric Ligand6C1Q-C5a1-PMX53-NDT9513727 6C1R-C5a1-PMX53-Avacopan; Na
33.33Consensuscb1_on_alloOrthosteric Ligand7WV9-CB1-PubMed 104895-ZCZ011-Gi2/&β;1/&γ;2
33.33Consensusccr_offOrthosteric Ligandccr5_off ccr8_off
33.33Consensusclass-a_onOrthosteric Ligandsensory_on amine_on lipid_on nucleotide_on peptide_on protein_on hcar_on steroid_on melatonin_on
33.33Consensusgal1_onOrthosteric Ligand7WQ3-GAL1-Galanin-Gi1/&β;1/&γ;2
33.33Consensusgal2_onOrthosteric Ligand7WQ4-GAL2-Galanin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
33.33Consensusgi_galaninOrthosteric Ligand7WQ3-GAL1-Galanin-Gi1/&β;1/&γ;2
33.33Consensusgo_peptideOrthosteric Ligandgo_opioid go_ghrelin go_compl-peptide go_galanin go_vasopressin
33.33Consensusgs_class-aOrthosteric Ligandgs_amine gs_nucleotide gs_lipid gs_peptide gs_protein gs_steroid
33.33Consensusgs_galaninOrthosteric Ligand7WQ4-GAL2-Galanin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
33.33Consensushca3_onOrthosteric Ligand8IHJ-HCA3-Acifran-Gi1/&β;1/&γ;2
33.33Consensushcar_offOrthosteric Ligandsuccinate_off
33.33Consensuss1p1_onOrthosteric Ligand7TD3-S1P1-S1P-Gi1/&β;1/&γ;2 7TD4-S1P1-Siponimod-Gi1/&β;1/&γ;2 7VIF-S1P1-(S)-FTY720-P-Gi1/&β;1/&γ;2 7EO4-S1P1-BAF312-Gi1/&β;1/&γ;2 7VIG-S1P1-CBP-307-Gi1/&β;1/&γ;2 7EVZ-S1P1-Cenerimod-Gi1/&β;1/&γ;2 7EW0-S1P1-Ozanimod-Gi1/&β;1/&γ;2 7EW7-S1P1-PubChem 4077460-Gi1/&β;1/&γ;2
33.33Consensussuccinate_offOrthosteric Ligand6RNK-Succinate-NF-56-EJ40 6Z10-Succinate-PubChem 154585554
33.33Consensusvip-pacap_onOrthosteric Ligandvpac1_on vpac2_on pca1_on
32.43Consensusclass-b1_onOrthosteric Ligandglucagon_on calcitonin_on vip-pacap_on pth_on crf_on
32.35Single8FLQPTH8FLQ-PTH1-PTH-Gs/&β;1/&γ;2
32.35Consensusgi_neuropeptideOrthosteric Ligand7YOO-Y2-Neuropeptide Y-Gi1/&β;1/&γ;2 7YON-Y2-Peptide YY(3-36)-Gi1/&β;1/&γ;2 7X9C-Y4-Pancreatic Hormone-Gi1/&β;1/&γ;2 7X9A-Y1-Neuropeptide Y-Gi1/&β;1/&γ;2
32.35Consensusmc2_onOrthosteric Ligand8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/&β;1/&γ;2; MRAP1
32.26Single7KI1Taspoglutide7KI1-GLP-1-Taspoglutide-Gs/&β;1/&γ;2
32.14Single5WB2CX3CL1.355WB2-US28-CX3CL1.35
32.14Single6JODAngiotensin II6JOD-AT2-Angiotensin II
32.14Single6MEOEnvelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd46MEO-CCR5-Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4
32.14Single6METEnvelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd46MET-CCR5-Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4
32.14Single7C61Ergotamine7C61-5-HT1B-Ergotamine
32.14Single7W40Bombesin7W40-BB2-Bombesin-chim(NtGi1L-Gq)/&β;1/&γ;2
32.14Single8HA0PTH8HA0-PTH1-PTH-chim(NtGi1-Gs)/&β;1/&γ;2
32.14Single8J6IMK68928J6I-HCA2-MK6892-Gi1/&β;1/&γ;2
32.14Consensusghrelin_onOrthosteric Ligand7W2Z-Ghrelin-Ghrelin-Go/&β;1/&γ;2 7F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7NA8-Ghrelin-PubChem 178024-Gi1/&β;1/&γ;2
32.00Single7F8WGastrin-177F8W-CCKB-Gastrin-17-chim(NtGsL-Gq)/&β;1/&γ;2
32.00Single7F9ZGHRP-67F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
32.00Single7RMGSubstance P7RMG-NK1-Substance P-chim(Gs-CtGq)/&β;1/&γ;2
32.00Single7XY6PubChem 117178317XY6-A2B-PubChem 11717831-chim(NtGi1-Gs)/&β;1/&γ;2
32.00Single8JBFSenktide8JBF-NK3-Senktide-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
32.00Single8JLRA776368JLR-TA1-A77636-chim(NtGi1-Gs)/&β;1/&γ;2
32.00Consensusgi_apelinOrthosteric Ligand7W0P-Apelin-Elabela-Gi1/&β;1/&γ;2 7W0M-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
32.00Consensusgi_lipidOrthosteric Ligandgi_cannabinoid gi_prostanoid gi_ffa gi_lpl gi_leukotriene
32.00Consensusgq_cckOrthosteric Ligand8IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/&β;1/&γ;2 7F8W-CCKB-Gastrin-17-chim(NtGsL-Gq)/&β;1/&γ;2 7EZM-CCKA-Cholecystokinin-8-chim(NtGsL-Gq)/&β;1/&γ;2 7XOW-CCKB-Gastrin-Gq/&β;1/&γ;2
32.00Consensuslpl_onOrthosteric Ligands1p_on lpa_on
32.00Consensusmc4_onOrthosteric Ligand7F53-MC4-Alpha-MSH-Gs/&β;1/&γ;2 7F55-MC4-Bremelanotide-Gs/&β;1/&γ;2 7PIV-MC4-Setmelanotide-Gs/&β;1/&γ;2 7F58-MC4-THIQ-Gs/&β;1/&γ;2 7F54-MC4-Afamelanotide-Gs/&β;1/&γ;2
32.00Consensusmotilin_onOrthosteric Ligand8IBV-Motilin-Motilin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IBU-Motilin-Erythromycin A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
32.00Consensusox2_onOrthosteric Ligand7L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7SR8-OX2-TAK-925-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
31.82Single6KPCPubChem 1459158896KPC-CB2-PubChem 145915889
31.82Single7C4SS1P7C4S-S1P3-S1P
31.82Single7EW3S1P7EW3-S1P3-S1P-Gi1/&β;1/&γ;2
31.82Single7YU6ONO-07405567YU6-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
31.82Single8FN1Neurotensin/neuromedin N8FN1-NTS1-Neurotensin/neuromedin N-chim(NtGi1-Go)/&β;1/&γ;2
31.82Single8JPCNeurotensin 8-138JPC-NTS1-Neurotensin 8-13-PubChem 118610427; GDP; Mg-Gq; GRK2
31.82Consensusrxfp4_onOrthosteric Ligand7YK7-RXFP4-DC591053-Gi2/&β;1/&γ;2 7YJ4-RXFP4-INSL5-Gi2/&β;1/&γ;2 7YK6-RXFP4-PubChem 138319674-Gi2/&β;1/&γ;2
31.58Single3V2WPubChem 518926453V2W-S1P1-PubChem 51892645
31.58Single7TRPLY20332987TRP-M4-Iperoxo-LY2033298-Gi1/&β;1/&γ;2
31.58Single8H2GNiacin8H2G-HCA2-Niacin-Gi1/&β;1/&γ;2
31.58Single8K5BNiacin8K5B-HCA2-Niacin
31.43Consensuspth_onOrthosteric Ligandpth1_on pth2_on
31.25Single7DUQGLP-17DUQ-GLP-1-GLP-1-PubChem 156022738-Gs/&β;1/&γ;2
31.25Consensusbb2_onOrthosteric Ligand7W40-BB2-Bombesin-chim(NtGi1L-Gq)/&β;1/&γ;2 7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/&β;1/&γ;2
31.25Consensusgq_bombesinOrthosteric Ligand7W40-BB2-Bombesin-chim(NtGi1L-Gq)/&β;1/&γ;2 7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/&β;1/&γ;2
31.03Single6X18GLP-16X18-GLP-1-GLP-1-Gs/&β;1/&γ;2
31.03Single7LLYOxyntomodulin7LLY-GLP-1-Oxyntomodulin-Gs/&β;1/&γ;2
31.03Single7X9BNeuropeptide Y7X9B-Y2-Neuropeptide Y-Gi1/&β;1/&γ;2
31.03Single8HCQEndothelin-18HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
31.03Single8KH5Lysophosphatidylserine8KH5-GPR174-Lysophosphatidylserine-Gs/&β;1/&γ;2
31.03Consensuseta_onOrthosteric Ligand8HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
31.03Consensusgq_class-aOrthosteric Ligandgq_amine gq_peptide
31.03Consensusgs_melanocortinOrthosteric Ligand7F4D-MC1-Alpha-MSH-chim(NtGi1-Gs)/&β;1/&γ;2 7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/&β;1/&γ;2 7F54-MC4-Afamelanotide-Gs/&β;1/&γ;2 7F53-MC4-Alpha-MSH-Gs/&β;1/&γ;2 7F55-MC4-Bremelanotide-Gs/&β;1/&γ;2 7PIV-MC4-Setmelanotide-Gs/&β;1/&γ;2 7F4I-MC1-SHU9119-chim(NtGi1-Gs)/&β;1/&γ;2 7F58-MC4-THIQ-Gs/&β;1/&γ;2
30.77Single6X19CHU-1286X19-GLP-1-CHU-128-Gs/&β;1/&γ;2
30.77Single7F4ISHU91197F4I-MC1-SHU9119-chim(NtGi1-Gs)/&β;1/&γ;2
30.77Single7F8XNN90567F8X-CCKA-NN9056
30.77Single7RMHSubstance P7RMH-NK1-Substance P-Gs/&β;1/&γ;2
30.77Single7VLACCL15(27-92)7VLA-CCR1-CCL15(27-92)-Gi1/&β;1/&γ;2
30.77Single7WKDTRH7WKD-TRH-TRH-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
30.77Single8J6RMK68928J6R-HCA2-MK6892-Gi1/&β;1/&γ;2
30.77Consensusalpha1a_offOrthosteric Ligand7YMJ-Alpha1A-Tamsulosin 8HN1-Alpha1A-Toxin AdTx1
30.77Consensusgi_ghrelinOrthosteric Ligand7NA7-Ghrelin-Ghrelin-27-Gi1/&β;1/&γ;2 7NA8-Ghrelin-PubChem 178024-Gi1/&β;1/&γ;2
30.77Consensusgo_class-aOrthosteric Ligandgo_amine go_peptide go_protein
30.77Consensussst_onOrthosteric Ligandsst2_on sst4_on
30.43Single4RWDDIPP-NH24RWD-δ-DIPP-NH2-Na
30.43Single4Z34ONO-97803074Z34-LPA1-ONO-9780307
30.43Single5XR8AM8415XR8-CB1-AM841
30.43Single5XRAAM115425XRA-CB1-AM11542
30.43Single6GT3Imaradenant6GT3-A2A-Imaradenant-Na
30.43Single6KO5PubChem 574000026KO5-Ghrelin-PubChem 57400002
30.43Single6OS1TRV0266OS1-AT1-TRV026
30.43Single7EW1Siponimod7EW1-S1P5-Siponimod-Gi1/&β;1/&γ;2
30.43Single7FEEPubMed 1048957FEE-CB1-PubMed 104895-ZCZ011
30.43Single7JVPSKF839597JVP-D1-SKF83959-Gs/&β;1/&γ;2
30.43Single7VIGCBP-3077VIG-S1P1-CBP-307-Gi1/&β;1/&γ;2
30.43Single7WV9PubMed 1048957WV9-CB1-PubMed 104895-ZCZ011-Gi2/&β;1/&γ;2
30.43Single8E0GBU728E0G-μ-BU72
30.43Single8GUSHU-3088GUS-CB2-HU-308-Gi1/&β;1/&γ;2
30.43Single8HQCC5a anaphylatoxin8HQC-C5a1-C5a anaphylatoxin-Go/&β;1/&γ;2
30.43Single8I9AEP548I9A-C3aB-EP54-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
30.43Consensusarrestin2Orthosteric Ligand6TKO-β1-Arformoterol-Arrestin2 6PWC-NTS1-Neurotensin-Arrestin2 7R0C-V2-Acyclovir triphosphate-Arrestin2
30.43Consensusgs_compl-peptideOrthosteric Ligand8I9A-C3aB-EP54-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
30.43Consensusrelaxin_onOrthosteric Ligandrxfp4_on
30.43Consensuss1p3_onOrthosteric Ligand7EW3-S1P3-S1P-Gi1/&β;1/&γ;2 7EW4-S1P3-CYM5541-Gi1/&β;1/&γ;2 7EW2-S1P3-Fingolimod-Gi1/&β;1/&γ;2
30.43Consensuss1p5_onOrthosteric Ligand7EW1-S1P5-Siponimod-Gi1/&β;1/&γ;2
30.30Single6LPBPACAP6LPB-PAC1-PACAP-Gs/&β;1/&γ;1
30.00Single6LFOInterleukin-86LFO-CXCR2-Interleukin-8-Gi1/&β;1/&γ;2
30.00Single6RNKNF-56-EJ406RNK-Succinate-NF-56-EJ40
30.00Single7D3SSecretin7D3S-Secretin-Secretin-Gs/&β;1/&γ;2
30.00Single7FIYTirzepatide7FIY-GIP-Tirzepatide-Gs/&β;1/&γ;2
30.00Single7RA3GIP7RA3-GIP-GIP-chim(NtGi1-Gs)/&β;1/&γ;2
30.00Single7SK3CXCL127SK3-ACKR3-CXCL12
30.00Single7T94PubChem 576644067T94-M2-Acetylcholine-PubChem 57664406-chim(NtGi1-Go)/&β;1/&γ;2
30.00Single7VABNon-Acylated Tirzepatide7VAB-GIP-Non-Acylated Tirzepatide-chim(NtGi1-Gs)/&β;1/&γ;2
30.00Single7VIHCBP-3077VIH-S1P1-CBP-307-Gi1/&β;1/&γ;2
30.00Single8GNGIstradefylline8GNG-A2A-Istradefylline
30.00Single8H0PNMB308H0P-BB1-NMB30-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
30.00Single8IHKAcifran8IHK-HCA3-Acifran
30.00Single8IJBAcipimox8IJB-HCA2-Acipimox-Gi1/&β;1/&γ;2
30.00Single8J6LNiacin8J6L-HCA2-Niacin-Gi1/&β;1/&γ;2
30.00Single8JISPeptide-158JIS-GLP-1-Peptide-15-chim(NtGi1-Gs)/&β;1/&γ;2
30.00Consensusbb1_onOrthosteric Ligand8H0P-BB1-NMB30-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
30.00Consensusbradykinin_onOrthosteric Ligandbk2_on bk1_on
30.00Consensusgi_neuromedinOrthosteric Ligand7XK8-NMUR2-Neuromedin-U-25-Gi1/&β;1/&γ;2
29.73Consensusglucagon_onOrthosteric Ligandgip_on glu_on secretin_on ghrh_on glp_on
29.73Consensusgs_pthOrthosteric Ligand8FLQ-PTH1-PTH-Gs/&β;1/&γ;2 7Y35-PTH1-Abaloparatide-Gs/&β;1/&γ;2 7Y36-PTH1-Teriparatide-Gs/&β;1/&γ;2 7F16-PTH2-TIP39-Gs/&β;1/&γ;2 7VVM-PTH1-PTH-Gs/&β;1/&γ;2 8FLU-PTH1-Long-acting PTH-Gs/&β;1/&γ;2 6NBF-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2
29.63Single7E14Orforglipron7E14-GLP-1-Orforglipron-PubChem 156022738-Gs/&β;1/&γ;2
29.63Single7W56Neuromedin-S7W56-NMUR1-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
29.63Single7XMSSomatostatin-147XMS-SST4-Somatostatin-14-Gi1/&β;1/&γ;2
29.63Single8F7WDynorphin8F7W-κ-Dynorphin-Gi1/&β;1/&γ;2
29.17Single6KQIPubMed 1048956KQI-CB1-PubMed 104895-ORG27569
29.17Single6XOXOrforglipron6XOX-GLP-1-Orforglipron-chim(NtGi1-Gs)/&β;1/&γ;2
29.17Single7DFPSpiperone7DFP-D2-Spiperone
29.17Single7EO4BAF3127EO4-S1P1-BAF312-Gi1/&β;1/&γ;2
29.17Single7JNIOlodanrigan7JNI-AT2-Olodanrigan
29.17Single7K15MKD0467K15-BLT1-MKD046-Na
29.17Single7WCNAR2314537WCN-GPR119-AR231453-Gs/&β;1/&γ;2
29.17Single7WQ4Galanin7WQ4-GAL2-Galanin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
29.17Single7X1TTaltirelin7X1T-TRH-Taltirelin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
29.17Single7XJKGalanin7XJK-GAL2-Galanin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
29.17Single8HK2C3a anaphylatoxin8HK2-C3aB-C3a anaphylatoxin-Gi1/&β;1/&γ;2
29.17Single8I9LC3a anaphylatoxin8I9L-C3aB-C3a anaphylatoxin-Go/&β;1/&γ;2
29.17Single8JJLOlodaterol8JJL-β2-Olodaterol
29.17Single8JZ7MK68928JZ7-HCA2-MK6892-Gi1/&β;1/&γ;2
29.17Single8U26Protachykinin-18U26-NK1-Protachykinin-1-Gs/&β;1/&γ;2
29.17Single8WU1KCA8WU1-CB1-KCA-Arrestin1
29.17Consensusat2_offOrthosteric Ligand7JNI-AT2-Olodanrigan
29.17Consensusblt1_offOrthosteric Ligand7K15-BLT1-MKD046-Na
29.17Consensusblt_offOrthosteric Ligandblt1_off
29.17Consensuscannabinoid_offOrthosteric Ligandcb1_off cb2_off
29.17Consensuscb1_off_alloOrthosteric Ligand6KQI-CB1-PubMed 104895-ORG27569
29.17Consensusd2_offOrthosteric Ligand6CM4-D2-Risperidone 6LUQ-D2-Haloperidol 7DFP-D2-Spiperone
29.17Consensusgpr119_onOrthosteric Ligand7XZ6-GPR119-APD668-Gs/&β;1/&γ;2 7WCN-GPR119-AR231453-Gs/&β;1/&γ;2 7XZ5-GPR119-Lysophosphatidylcholine-Gs/&β;1/&γ;2 7WCM-GPR119-MBX-2982-Gs/&β;1/&γ;2
29.17Consensusleuko_offOrthosteric Ligandblt_off cyslt_off
29.17Consensuslpa1_offOrthosteric Ligand4Z36-LPA1-ONO-3080573 4Z34-LPA1-ONO-9780307 4Z35-LPA1-ONO-9910539 7YU4-LPA1-ONO-0740556
29.17Consensuss1p_onOrthosteric Ligands1p3_on s1p5_on s1p1_on s1p2_on
29.03Single6VCBGLP-16VCB-GLP-1-GLP-1-LSN3160440-Gs/&β;1/&γ;2
29.03Single7F4FAfamelanotide7F4F-MC1-Afamelanotide-chim(NtGi1-Gs)/&β;1/&γ;2
29.03Single7F53Alpha-MSH7F53-MC4-Alpha-MSH-Gs/&β;1/&γ;2
29.03Single7VVJPTHrP(1-36)7VVJ-PTH1-PTHrP(1-36)-Gs/&β;1/&γ;2
29.03Consensusendothelin_onOrthosteric Ligandetb_on eta_on
29.03Consensusetb_onOrthosteric Ligand8HCX-ETB-Endothelin-1-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8HBD-ETB-IRL1620-Gi1/&β;1/&γ;2
28.57Single6W25SHU91196W25-MC4-SHU9119-Ca
28.57Single6WJCMuscarinic toxin 76WJC-M1-Atropine-Muscarinic toxin 7
28.57Single6ZFZ77-LH-28-16ZFZ-M1-77-LH-28-1
28.57Single6ZG9GSK10347026ZG9-M1-GSK1034702
28.57Single7C2EPubChem 1490507997C2E-GLP-1-PubChem 149050799-Gs/&β;1/&γ;2
28.57Single7F4DAlpha-MSH7F4D-MC1-Alpha-MSH-chim(NtGi1-Gs)/&β;1/&γ;2
28.57Single7TD0LPA7TD0-LPA1-LPA-Gi1/&β;1/&γ;2
28.57Single7XOUCholecystokinin-87XOU-CCKA-Cholecystokinin-8-Gs/&β;1/&γ;2
28.57Single7Y36Teriparatide7Y36-PTH1-Teriparatide-Gs/&β;1/&γ;2
28.57Single8GUQOlorinab8GUQ-CB2-Olorinab-Gi1/&β;1/&γ;2
28.57Single8JHNMMF8JHN-HCA2-MMF-Go/&β;1/&γ;2
28.57Single8XZHMM078XZH-Apelin-MM07-Gi1/&β;1/&γ;2
28.57Consensusgs_glucagonOrthosteric Ligand6X18-GLP-1-GLP-1-Gs/&β;1/&γ;2 6B3J-GLP-1-Exendin-P5-Gs/&β;1/&γ;2 6WZG-Secretin-Secretin-Gs/&β;1/&γ;2 6X1A-GLP-1-Danuglipron-Gs/&β;1/&γ;2 7CZ5-GHRH-Somatoliberin-Gs/&β;1/&γ;2 7D68-GLP-2-GLP-2-Gs/&β;1/&γ;2 7DTY-GIP-GIP-Gs/&β;1/&γ;2 7FIM-GLP-1-Tirzepatide-Gs/&β;1/&γ;2 7FIN-GIP-Peptide-20; GGL-Gs/&β;1/&γ;2 7FIY-GIP-Tirzepatide-Gs/&β;1/&γ;2 7KI0-GLP-1-Semaglutide-Gs/&β;1/&γ;2 7RTB-GLP-1-Peptide-19-Gs/&β;1/&γ;2 7S1M-GLP-1-Ex4-D-Ala-Gs/&β;1/&γ;2 7VAB-GIP-Non-Acylated Tirzepatide-chim(NtGi1-Gs)/&β;1/&γ;2 8JIU-Glucagon-SAR425899-Gs/&β;1/&γ;2
28.57Consensusgs_motilinOrthosteric Ligand8IBV-Motilin-Motilin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IBU-Motilin-Erythromycin A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
28.57Consensusgs_tachykininOrthosteric Ligand8U26-NK1-Protachykinin-1-Gs/&β;1/&γ;2 7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7P00-NK1-Substance P-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
28.57Consensusm1_off_alloOther Ligand6WJC-M1-Atropine-Muscarinic toxin 7
28.57Consensusnpy1_onOrthosteric Ligand7X9A-Y1-Neuropeptide Y-Gi1/&β;1/&γ;2
28.57Consensusnpy_onOrthosteric Ligandnpy2_on npy4_on npy1_on
28.57Consensustachykinin_onOrthosteric Ligandnk1_on nk2_on
28.12Single6B3JExendin-P56B3J-GLP-1-Exendin-P5-Gs/&β;1/&γ;2
28.12Single6IGLIRL16206IGL-ETB-IRL1620
28.12Single6LMLGlucagon6LML-Glucagon-Glucagon
28.12Single6PB1Urocortin6PB1-CRF2-Urocortin-chim(NtGi1-Gs)/&β;1/&γ;2
28.12Single7VGXNeuropeptide Y7VGX-Y1-Neuropeptide Y-Gi1/&β;1/&γ;2
28.12Single7VVLPTH7VVL-PTH1-PTH-Gs/&β;1/&γ;2
28.12Single8HAFPTHrP(1-36)8HAF-PTH1-PTHrP(1-36)-chim(NtGi1-Gs)/&β;1/&γ;2
28.12Single8IY6Endothelin-18IY6-ETB-Endothelin-1
28.00Single4Z35ONO-99105394Z35-LPA1-ONO-9910539
28.00Single5UNHPubChem 1264564065UNH-AT2-PubChem 126456406
28.00Single6DDFDamgo6DDF-μ-Damgo-Gi1/&β;1/&γ;2
28.00Single7EZMCholecystokinin-87EZM-CCKA-Cholecystokinin-8-chim(NtGsL-Gq)/&β;1/&γ;2
28.00Single7P00Substance P7P00-NK1-Substance P-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
28.00Single7SK7CCX6627SK7-ACKR3-CXCL12-CCX662
28.00Single7X2DTavapadon7X2D-D1-Tavapadon-Gs/&β;1/&γ;2
28.00Single7XK2MK68927XK2-HCA2-MK6892-Gi1/&β;1/&γ;2
28.00Single7XZ6APD6687XZ6-GPR119-APD668-Gs/&β;1/&γ;2
28.00Single7YU8ONO-07405567YU8-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
28.00Single8GAGYVF8GAG-CB1-YVF-Gi1/&β;1/&γ;2
28.00Single8GUTLEI-1028GUT-CB2-LEI-102-Gi1/&β;1/&γ;2
28.00Single8K2XCXCL108K2X-CXCR3-CXCL10-Gi1/&β;1/&γ;2
28.00Consensuscckb_onOrthosteric Ligand7XOW-CCKB-Gastrin-Gq/&β;1/&γ;2 7F8W-CCKB-Gastrin-17-chim(NtGsL-Gq)/&β;1/&γ;2 8IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/&β;1/&γ;2
28.00Consensusgs_cckOrthosteric Ligand7MBX-CCKA-Cholecystokinin-8-Gs/&β;1/&γ;1 7XOV-CCKA-SR146131-Gs/&β;1/&γ;2
28.00Consensusgs_orexinOrthosteric Ligand7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7SR8-OX2-TAK-925-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
28.00Consensusorexin_onOrthosteric Ligandox2_on
27.59Single5YQZGlucagon analogue5YQZ-Glucagon-Glucagon analogue
27.59Single7DW9Acyclovir triphosphate7DW9-V2-Acyclovir triphosphate-chim(NtGi1-Gs)/&β;1/&γ;2
27.59Single8H4KGW95088H4K-FFA4-GW9508-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
27.59Single8IHFMK68928IHF-HCA2-MK6892-Gi1/&β;1/&γ;2
27.59Consensusgi_somatostatinOrthosteric Ligand7XMR-SST2-Somatostatin-14-Gi1/&β;1/&γ;2 7XMT-SST4-J-2156-Gi1/&β;1/&γ;2 7XAU-SST2-Octreotide-Gi1/&β;1/&γ;2 7YAC-SST2-Paltusotine-Gi1/&β;1/&γ;2
27.59Consensusnmur2_onOrthosteric Ligand7W57-NMUR2-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
27.59Consensusnmur_onOrthosteric Ligandnmur1_on nmur2_on
27.59Consensusv2_onOrthosteric Ligand7DW9-V2-Acyclovir triphosphate-chim(NtGi1-Gs)/&β;1/&γ;2
27.50Single8GY7Corticotropin8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/&β;1/&γ;2; MRAP1
27.27Single4EA3PubChem 102965614EA3-NOP-PubChem 10296561
27.27Single5UIGJ3.651.884G5UIG-A2A-J3.651.884G
27.27Single6KPFPubChem 1459158896KPF-CB2-PubChem 145915889-Gi1/&β;1/&γ;2
27.27Single6ORVTT-OAD26ORV-GLP-1-TT-OAD2-Gs/&β;1/&γ;2
27.27Single6X1ADanuglipron6X1A-GLP-1-Danuglipron-Gs/&β;1/&γ;2
27.27Single7LCKDanuglipron7LCK-GLP-1-Danuglipron
27.27Single7T6VfMLFII7T6V-FPR2-ALX-fMLFII-Gi1/&β;1/&γ;2
27.27Single7VIF(S)-FTY720-P7VIF-S1P1-(S)-FTY720-P-Gi1/&β;1/&γ;2
27.27Single7YK7DC5910537YK7-RXFP4-DC591053-Gi2/&β;1/&γ;2
27.27Single7YU4ONO-07405567YU4-LPA1-ONO-0740556
27.27Single8CU6LJ-45178CU6-A2A-LJ-4517
27.27Single8KFYZK-7563268KFY-CCR8-ZK-756326-Gi1/&β;1/&γ;2
27.27Single8X17Namodenoson8X17-A3A-Namodenoson-Gi1/&β;1/&γ;2
27.27Consensusgs_crfOrthosteric Ligand6P9X-CRF1-Corticoliberin-Gs/&β;1/&γ;2
27.27Consensusnucleotide_offOrthosteric Ligandadenosine_off p2y_off
27.27Consensusprostanoid_offOrthosteric Ligandep_off tp_off dp_off
26.92Single4UG2CGS216804UG2-A2A-CGS21680
26.92Single5ZTYAM102575ZTY-CB2-AM10257
26.92Single7X1UTRH7X1U-TRH-TRH-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
26.92Single7X8SWB4-247X8S-GLP-1-WB4-24-Gs/&β;1/&γ;2
26.92Single7Y1FDynorphin7Y1F-κ-Dynorphin-Gi1/&β;1/&γ;2
26.92Single7YJ4INSL57YJ4-RXFP4-INSL5-Gi2/&β;1/&γ;2
26.92Single8IA7Cholecystokinin-88IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/&β;1/&γ;2
26.92Single8IYHMK68928IYH-HCA2-MK6892-Go/&β;1/&γ;2
26.92Consensuscb2_offOrthosteric Ligand5ZTY-CB2-AM10257
26.92Consensusnk1_onOrthosteric Ligand8U26-NK1-Protachykinin-1-Gs/&β;1/&γ;2 7P00-NK1-Substance P-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
26.92Consensusste2_offOrthosteric Ligand7QA8-STE2-Peptide
26.67Single6UUNAdrenomedullin6UUN-CT Like (AM1)-Adrenomedullin-Gs/&β;1/&γ;2; RAMP2
26.67Single7P02Protachykinin-17P02-NK1-Protachykinin-1-chim(NtGi1-Gs)/&β;1/&γ;2
26.67Single7TRYUrocortin7TRY-CRF2-Urocortin-chim(NtGi1-G11)/&β;1/&γ;2
26.67Single7XATSomatostatin-147XAT-SST2-Somatostatin-14-Gi1/&β;1/&γ;2
26.67Consensusbk1_onOrthosteric Ligand7EIB-BK1-Des-Arg10-Kallidin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
26.67Consensusbombesin_onOrthosteric Ligandbb2_on bb1_on
26.67Consensusgs_bradykininOrthosteric Ligand7F2O-BK2-Bradykinin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7EIB-BK1-Des-Arg10-Kallidin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
26.67Consensusgs_neuromedinOrthosteric Ligand7W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7W56-NMUR1-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7W57-NMUR2-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
26.47Single7VBHPeptide-207VBH-GLP-1-Peptide-20-Gs/&β;1/&γ;2
26.47Single8FLSAbaloparatide8FLS-PTH1-Abaloparatide-Gs/&β;1/&γ;2
26.47Single8FLULong-acting PTH8FLU-PTH1-Long-acting PTH-Gs/&β;1/&γ;2
26.47Single8HBDIRL16208HBD-ETB-IRL1620-Gi1/&β;1/&γ;2
26.47Consensusgi_endothelinOrthosteric Ligand8IY5-ETB-Endothelin-1-Gi1/&β;1/&γ;2 8HBD-ETB-IRL1620-Gi1/&β;1/&γ;2
26.32Single8J6QBeta-hydroxybutyrate8J6Q-HCA2-Beta-hydroxybutyrate-Compound 9n-Gi1/&β;1/&γ;2
26.09Single5C1MBU725C1M-μ-BU72
26.09Single5N2SPSB365N2S-A1-PSB36
26.09Single5OM4PubChem 1355666095OM4-A2A-PubChem 135566609-Na
26.09Single5YHLPubChem 1351213525YHL-EP4-PubChem 135121352
26.09Single5YWYONO-AE3-2085YWY-EP4-ONO-AE3-208
26.09Single6ME72-Phenylmelatonin6ME7-MT2-2-Phenylmelatonin
26.09Single6N4BMDMB-Fubinaca6N4B-CB1-MDMB-Fubinaca-Gi1/&β;1/&γ;2
26.09Single7BZ2Arformoterol7BZ2-β2-Arformoterol-Gs/&β;1/&γ;2
26.09Single7CFNINT-7777CFN-GPBA-INT-777-Gs/&β;1/&γ;2
26.09Single7CKXA776367CKX-D1-A77636-Gs/&β;1/&γ;2
26.09Single7LD3Adenosine7LD3-A1-Adenosine-PubChem 25263603-Gi2/&β;1/&γ;2
26.09Single7YU3ONO-07405567YU3-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
26.09Single7YU7ONO-07405567YU7-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
26.09Single7YXAONO-54306087YXA-S1P5-ONO-5430608
26.09Single8DZQmomSalB8DZQ-κ-momSalB-Go/&β;1/&γ;2
26.09Single8DZRGR89,6968DZR-κ-GR89,696-chim(NtGi2-Gt3)/&β;1/&γ;2
26.09Single8EFBOliceridine8EFB-μ-Oliceridine-Gi1/&β;1/&γ;2
26.09Single8HNLPS3724248HNL-CXCR3-PS372424-Gi1/&β;1/&γ;2
26.09Single8K8JFenofibrate8K8J-CB1-Fenofibrate-chim(Gs-CtGq)/&β;1/&γ;2
26.09Single8KFXLMD-0098KFX-CCR8-LMD-009-Gi1/&β;1/&γ;2
26.09Consensusa1_on_alloOrthosteric Ligand7LD3-A1-Adenosine-PubChem 25263603-Gi2/&β;1/&γ;2
26.09Consensusd1_onOrthosteric Ligand7F0T-D1-Dopamine-Gs/&β;1/&γ;2 7CKY-D1-PW0464-Gs/&β;1/&γ;2 8IRR-D1-Rotigotine-Gs/&β;1/&γ;2 7JV5-D1-SKF81297-Gs/&β;1/&γ;2 7JVP-D1-SKF83959-Gs/&β;1/&γ;2 7X2D-D1-Tavapadon-Gs/&β;1/&γ;2 7JOZ-D1-VFP-Gs/&β;1/&γ;2 7CKX-D1-A77636-Gs/&β;1/&γ;2 7JVQ-D1-Apomorphine-Gs/&β;1/&γ;2
26.09Consensusd2_onOrthosteric Ligand7JVR-D2-Bromoergocryptine-Gi1/&β;1/&γ;2 8IRS-D2-Rotigotine-Gi1/&β;1/&γ;2
26.09Consensusep4_offOrthosteric Ligand5YWY-EP4-ONO-AE3-208 5YHL-EP4-PubChem 135121352
26.09Consensusep_offOrthosteric Ligandep4_off
26.09Consensusgo_opioidOrthosteric Ligand8DZQ-κ-momSalB-Go/&β;1/&γ;2
25.93Single7L0RNeurotensin7L0R-NTS1-Neurotensin-Gi1/&β;1/&γ;1
25.93Single7TD4Siponimod7TD4-S1P1-Siponimod-Gi1/&β;1/&γ;2
25.93Single7WVWfMYFINILTL7WVW-FPR2-ALX-fMYFINILTL-Gi2/&β;1/&γ;2
25.93Single8DCRDobutamine8DCR-β1-Dobutamine-Gs/&β;1/&γ;2
25.93Single8GHVPubChem 1459649038GHV-CB1-PubChem 145964903-Gi1/&β;1/&γ;2
25.93Single8JIQPeptide-158JIQ-Glucagon-Peptide-15-Gs/&β;1/&γ;2
25.93Consensusfpr-alx_onOrthosteric Ligandfpr1-alx_on fpr2-alx_on
25.93Consensusmop_offOrthosteric Ligand7UL4-μ-Alvimopan 4DKL-μ-Beta-funaltrexamine 8QOT-μ-Nanobody E
25.93Consensusnmur1_onOrthosteric Ligand7W56-NMUR1-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
25.93Consensusnop_onOrthosteric Ligand8F7X-NOP-Nociceptin-Gi1/&β;1/&γ;2
25.93Consensusste2_offOrthosteric Ligand7QA8-STE2-Peptide
25.81Single6NBFLong-acting PTH analog6NBF-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2
25.81Single6NBILong-acting PTH analog6NBI-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2
25.81Single7CZ5Somatoliberin7CZ5-GHRH-Somatoliberin-Gs/&β;1/&γ;2
25.81Single7KI0Semaglutide7KI0-GLP-1-Semaglutide-Gs/&β;1/&γ;2
25.81Single7SK4CXCL12_LRHQ7SK4-ACKR3-CXCL12_LRHQ
25.81Single7W3ZGastrin Releasing Peptide7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/&β;1/&γ;2
25.81Consensusgs_vasopressin-otOrthosteric Ligand7RYC-OT-Oxytocin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 7DW9-V2-Acyclovir triphosphate-chim(NtGi1-Gs)/&β;1/&γ;2
25.81Consensuskop_onOrthosteric Ligand8F7W-κ-Dynorphin-Gi1/&β;1/&γ;2 8DZR-κ-GR89,696-chim(NtGi2-Gt3)/&β;1/&γ;2 8DZP-κ-momSalB-Gi1/&β;1/&γ;2 8FEG-κ-PRD_002517-Gi1/&β;1/&γ;2
25.81Consensusnpy4_onOrthosteric Ligand7X9C-Y4-Pancreatic Hormone-Gi1/&β;1/&γ;2
25.71Single7V35Peptide-207V35-Glucagon-Peptide-20-Gs/&β;1/&γ;2
25.71Single7VVMPTH7VVM-PTH1-PTH-Gs/&β;1/&γ;2
25.00Single3QAKUK-4320973QAK-A2A-UK-432097
25.00Single3SN6BI1671073SN6-β2-BI167107-Gs/&β;1/&γ;2
25.00Single4DJHJDTic4DJH-κ-JDTic
25.00Single4IAQDihydroergotamine4IAQ-5-HT1B-Dihydroergotamine
25.00Single4MQTLY21196204MQT-M2-Iperoxo-LY2119620
25.00Single4RWADIPP-NH24RWA-δ-DIPP-NH2
25.00Single5XJM(Sar1,Ile8)-Angiotensin II5XJM-AT2-(Sar1,Ile8)-Angiotensin II
25.00Single6NI3BI1671076NI3-β2-BI167107-Gs/&β;1/&γ;2
25.00Single6U1NLY21196206U1N-M2-LY2119620-Arrestin2
25.00Single7AUESetmelanotide7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/&β;1/&γ;2
25.00Single7B6WCyclazosin7B6W-α1b-Cyclazosin
25.00Single7C6A(Sar1,Ile8)-Angiotensin II7C6A-AT2-(Sar1,Ile8)-Angiotensin II
25.00Single7CKYPW04647CKY-D1-PW0464-Gs/&β;1/&γ;2
25.00Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
25.00Single7DTYGIP7DTY-GIP-GIP-Gs/&β;1/&γ;2
25.00Single7EIBDes-Arg10-Kallidin7EIB-BK1-Des-Arg10-Kallidin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
25.00Single7EW7PubChem 40774607EW7-S1P1-PubChem 4077460-Gi1/&β;1/&γ;2
25.00Single7F58THIQ7F58-MC4-THIQ-Gs/&β;1/&γ;2
25.00Single7JV5SKF812977JV5-D1-SKF81297-Gs/&β;1/&γ;2
25.00Single7PIUSetmelanotide7PIU-MC4-Setmelanotide-Gs/&β;1/&γ;2
25.00Single7PIVSetmelanotide7PIV-MC4-Setmelanotide-Gs/&β;1/&γ;2
25.00Single7PX4PSB-21137PX4-A2A-PSB-2113
25.00Single7RMISubstance P7RMI-NK1-Substance P-chim(Gs-CtGq)/&β;1/&γ;2
25.00Single7S1MEx4-D-Ala7S1M-GLP-1-Ex4-D-Ala-Gs/&β;1/&γ;2
25.00Single7T2HLofentanil7T2H-μ-Lofentanil-Gi1/&β;1/&γ;2
25.00Single7VBINon-Acylated Tirzepatide7VBI-GLP-1-Non-Acylated Tirzepatide-Gs/&β;1/&γ;2
25.00Single7VQXPACAP277VQX-VPAC1-PACAP27-Gs/&β;1/&γ;2
25.00Single7WVYAmyloid-Beta427WVY-FPR2-ALX-Amyloid-Beta42-Gi2/&β;1/&γ;2
25.00Single7X9ANeuropeptide Y7X9A-Y1-Neuropeptide Y-Gi1/&β;1/&γ;2
25.00Single7XJLSpexin7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
25.00Single7XOWGastrin7XOW-CCKB-Gastrin-Gq/&β;1/&γ;2
25.00Single7XOXCholecystokinin-87XOX-CCKB-Cholecystokinin-8-Gq/&β;1/&γ;2
25.00Single7Y67C089 peptide7Y67-C5a1-C089 peptide-Gi1/&β;1/&γ;2
25.00Single7YU5ONO-07405567YU5-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
25.00Single8DZPmomSalB8DZP-κ-momSalB-Gi1/&β;1/&γ;2
25.00Single8EF5Fentanyl8EF5-μ-Fentanyl-Gi1/&β;1/&γ;2
25.00Single8EFLSR170188EFL-μ-SR17018-Gi1/&β;1/&γ;2
25.00Single8F7QBeta-endorphin8F7Q-μ-Beta-endorphin-Gi1/&β;1/&γ;2
25.00Single8FX5Xanomeline8FX5-M4-Xanomeline-Xanomeline-Gi1/&β;1/&γ;2
25.00Single8GGCEpinephrine8GGC-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
25.00Single8GGEEpinephrine8GGE-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
25.00Single8GH1Epinephrine8GH1-β2-Epinephrine
25.00Single8H8JLodoxamide8H8J-GPR35-Lodoxamide-Ca-chim(NtGi1L-G13)/&β;1/&γ;2
25.00Single8HDOBAY 60-65838HDO-A2B-BAY 60-6583-Gs/&β;1/&γ;2
25.00Single8HPTC5a anaphylatoxin C-terminal peptide8HPT-C5a1-C5a anaphylatoxin C-terminal peptide-Go/&β;1/&γ;2
25.00Single8IHIAcifran8IHI-HCA2-Acifran-Gi1/&β;1/&γ;2
25.00Single8IJANiacin8IJA-HCA2-Niacin-Gi1/&β;1/&γ;2
25.00Single8IY9Niacin8IY9-HCA2-Niacin-Go/&β;1/&γ;2
25.00Single8JILNiacin8JIL-HCA2-Niacin-Gi1/&β;1/&γ;2
25.00Single8JT6(R)-IHCH-71798JT6-5-HT1A-(R)-IHCH-7179-Gi1/&β;1/&γ;2
25.00Consensusalpha1b_offOrthosteric Ligand7B6W-α1b-Cyclazosin
25.00Consensusangiotensin_offOrthosteric Ligandat1_off at2_off
25.00Consensusgi_dopamineOrthosteric Ligand8IRT-D3-Rotigotine-Gi1/&β;1/&γ;2 7JVR-D2-Bromoergocryptine-Gi1/&β;1/&γ;2 8IRS-D2-Rotigotine-Gi1/&β;1/&γ;2 7CMV-D3-PD128907-Gi1/&β;1/&γ;2 7CMU-D3-Pramipexole-Gi1/&β;1/&γ;2
25.00Consensusgo_class-b1Orthosteric Ligandgo_crf
25.00Consensusgo_crfOrthosteric Ligand7TS0-CRF2-Urocortin-chim(NtGi1L-Go)/&β;1/&γ;2
25.00Consensusgs_dopamineOrthosteric Ligand7F0T-D1-Dopamine-Gs/&β;1/&γ;2 7CKX-D1-A77636-Gs/&β;1/&γ;2 7JVQ-D1-Apomorphine-Gs/&β;1/&γ;2 7CKY-D1-PW0464-Gs/&β;1/&γ;2 8IRV-D5-Rotigotine-chim(NtGi1-Gs)/&β;1/&γ;2 7JV5-D1-SKF81297-Gs/&β;1/&γ;2 7JVP-D1-SKF83959-Gs/&β;1/&γ;2 7X2D-D1-Tavapadon-Gs/&β;1/&γ;2 7JOZ-D1-VFP-Gs/&β;1/&γ;2
25.00Consensuskop_offOrthosteric Ligand4DJH-κ-JDTic
25.00Consensuslpa1_onOrthosteric Ligand7TD0-LPA1-LPA-Gi1/&β;1/&γ;2 7YU3-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
25.00Consensuslpa_offOrthosteric Ligandlpa1_off
25.00Consensuslpa_onOrthosteric Ligandlpa1_on
25.00Consensusm4_on_alloOther Ligand7TRP-M4-Iperoxo-LY2033298-Gi1/&β;1/&γ;2 7TRQ-M4-Iperoxo-VU0467154-Gi1/&β;1/&γ;2 7V68-M4-Iperoxo-PubChem 57664406-Gi1/&β;1/&γ;2
24.39Consensusgs_class-b1Orthosteric Ligandgs_glucagon gs_vip-pacap gs_pth gs_calcitonin gs_crf
24.32Single6E3YCalcitonin gene-related peptide-16E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/&β;1/&γ;2; RAMP1
24.32Single8JIUSAR4258998JIU-Glucagon-SAR425899-Gs/&β;1/&γ;2
24.32Consensusgs_class-bOrthosteric Ligandgs_class-b1 gs_class-b2
24.24Single6UUSAdrenomedullin6UUS-CT Like (AM2)-Adrenomedullin-Gs/&β;1/&γ;2; RAMP3
24.24Single7VVKPTH7VVK-PTH1-PTH-Gs/&β;1/&γ;2
24.24Single8FEGPRD_0025178FEG-κ-PRD_002517-Gi1/&β;1/&γ;2
24.24Single8IY5Endothelin-18IY5-ETB-Endothelin-1-Gi1/&β;1/&γ;2
24.24Consensuscrf_onOrthosteric Ligandcrf2_on crf1_on
24.24Consensusgq_bradykininOrthosteric Ligand7F6H-BK2-Bradykinin-Gq/&β;1/&γ;2 7F6I-BK2-Kallidin-Gq/&β;1/&γ;2
24.24Consensusgs_endothelinOrthosteric Ligand8HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8HCX-ETB-Endothelin-1-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
24.24Consensusvpac2_onOrthosteric Ligand7VQX-VPAC1-PACAP27-Gs/&β;1/&γ;2
24.14Single5WF5UK-4320975WF5-A2A-UK-432097
24.14Single6LW5WKYMVm6LW5-FPR2-ALX-WKYMVm
24.14Single6PT2KGCHM076PT2-δ-KGCHM07
24.14Single7TD2LPA7TD2-LPA1-LPA-Gi1/&β;1/&γ;2
24.14Single7W55Neuromedin-U-257W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
24.14Single7XNACYN1548067XNA-SST2-CYN154806
24.14Single8XZGApelin-138XZG-Apelin-Apelin-13-Gi1/&β;1/&γ;2
24.14Consensusgi_formylpeptideOrthosteric Ligand7VFX-FPR1-ALX-fMLF-Gi1/&β;1/&γ;2 7T6T-FPR1-ALX-fMLFII-Gi1/&β;1/&γ;2 7WVY-FPR2-ALX-Amyloid-Beta42-Gi2/&β;1/&γ;2 7T6U-FPR2-ALX-CGEN-855A-Gi1/&β;1/&γ;2 7WVV-FPR2-ALX-fMLFII-Gi2/&β;1/&γ;2 7WVW-FPR2-ALX-fMYFINILTL-Gi2/&β;1/&γ;2 7WVX-FPR2-ALX-Humanin-Gi2/&β;1/&γ;2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/&β;1/&γ;2 6OMM-FPR2-ALX-WKYMVX-Gi1/&β;1/&γ;2
24.14Consensusmc3_onOrthosteric Ligand8IOC-MC3-Gamma-MSH-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
24.14Consensusmc5_onOrthosteric Ligand8INR-MC5-Alpha-MSH-Ca-chim(NtGi1-Gs)/&β;1/&γ;2 8IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
24.14Consensussst2_offOrthosteric Ligand7XNA-SST2-CYN154806
24.00Single4XEENeurotensin4XEE-NTS1-Neurotensin
24.00Single4XESNeurotensin4XES-NTS1-Neurotensin
24.00Single4Z36ONO-30805734Z36-LPA1-ONO-3080573
24.00Single6A93Risperidone6A93-5-HT2A-Risperidone
24.00Single6AK3Dinoprostone IPGE26AK3-EP3-Dinoprostone IPGE2
24.00Single6IIURamatroban6IIU-TP-Ramatroban
24.00Single6ME62-Phenylmelatonin6ME6-MT2-2-Phenylmelatonin
24.00Single6MXTSalmeterol6MXT-β2-Salmeterol
24.00Single6OSAJMV4496OSA-NTS1-JMV449-Gi1/&β;1/&γ;2
24.00Single6VMSBromoergocryptine6VMS-D2-Bromoergocryptine-Gi1/&β;1/&γ;2
24.00Single6YVRNTS8-136YVR-NTS1-NTS8-13
24.00Single6ZG4HTL00099366ZG4-M1-HTL0009936
24.00Single7DH5Mirabegron7DH5-β3-Mirabegron-Gs/&β;1/&γ;2
24.00Single7EVYSiponimod7EVY-S1P1-Siponimod-Gi1/&β;1/&γ;2
24.00Single7F55Bremelanotide7F55-MC4-Bremelanotide-Gs/&β;1/&γ;2
24.00Single7L1VPubChem 1554910097L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
24.00Single7SUSPubChem 1227019087SUS-Apelin-PubChem 122701908
24.00Single7W0LPubChem 1227019087W0L-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
24.00Single7W0LPubChem 1227019087W0L-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
24.00Single7Y66BM2137Y66-C5a1-BM213-Gi1/&β;1/&γ;2
24.00Single7YITNalfurafine7YIT-κ-Nalfurafine
24.00Single7YMJTamsulosin7YMJ-Alpha1A-Tamsulosin
24.00Single8GCPPGE28GCP-EP4-PGE2-Gi1/&β;1/&γ;2
24.00Single8IJDMK68928IJD-HCA2-MK6892-Gi1/&β;1/&γ;2
24.00Single8IRVRotigotine8IRV-D5-Rotigotine-chim(NtGi1-Gs)/&β;1/&γ;2
24.00Single8J6DEP1418J6D-C3aB-EP141-Go/&β;1/&γ;2
24.00Single8JWYPubChem 1684517108JWY-A2A-PubChem 168451710
24.00Single8JWZAB9288JWZ-A2A-AB928-Na
24.00Consensusgi_prostanoidOrthosteric Ligand8GCP-EP4-PGE2-Gi1/&β;1/&γ;2 8GDC-EP3-PGE2-Gi1/&β;1/&γ;2 8GCM-EP4-L902688-Gi1/&β;1/&γ;2
24.00Consensusgs_bileacidOrthosteric Ligand7CFN-GPBA-INT-777-Gs/&β;1/&γ;2 7CFM-GPBA-P395-Gs/&β;1/&γ;2 7XTQ-GPBA-R399-Gs/&β;1/&γ;2
24.00Consensusgs_steroidOrthosteric Ligandgs_bileacid
24.00Consensusopioid_offOrthosteric Ligandkop_off mop_off nop_off dop_off
24.00Consensuspeptide_offOrthosteric Ligandopioid_off angiotensin_off bombesin_off cck_off endothelin_off ghrelin_off npy_off nts_off orexin_off vasopressin-ot_off tachykinin_off sst_off
23.81Single2X72All-trans-retinal2X72-Rhodopsin-All-trans-retinal-Gt(CT)
23.81Single3PWHZM2413853PWH-A2A-ZM241385
23.81Single3VGAZM2413853VGA-A2A-ZM241385-Antibody
23.81Single5DHHSB-6121115DHH-NOP-SB-612111
23.81Single5U09Taranabant5U09-CB1-Taranabant
23.81Single6AKXA4R6AKX-CCR5-A4R
23.81Single6AKYMaraviroc6AKY-CCR5-Maraviroc
23.81Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
23.81Single7LCJDanuglipron7LCJ-GLP-1-Danuglipron
23.81Single7LD4Adenosine7LD4-A1-Adenosine-Gi2/&β;1/&γ;2
23.81Single7W0OElabela7W0O-Apelin-Elabela-Gi1/&β;1/&γ;2
23.81Single7X2CFenoldopam7X2C-D1-Fenoldopam-Fenoldopam-Gs/&β;1/&γ;2
23.81Single7XRRLemborexant7XRR-OX2-Lemborexant
23.81Single8EFOPZM218EFO-μ-PZM21-Gi1/&β;1/&γ;2
23.81Single8U4PAMD31008U4P-CXCR4-AMD3100-Cholesterol-Gi1/&β;1/&γ;2
23.81Single8UO3Epinephrine8UO3-β2-Epinephrine-GTP; Mg-Gs/&β;1/&γ;2
23.81Consensusa1_onOrthosteric Ligand7LD4-A1-Adenosine-Gi2/&β;1/&γ;2
23.81Consensuscxcr1_onOrthosteric Ligand8IC0-CXCR1-Interleukin-8-Gi1/&β;1/&γ;2
23.81Consensusgi_nucleotideOrthosteric Ligand7LD4-A1-Adenosine-Gi2/&β;1/&γ;2
23.53Single5VAIGLP-15VAI-GLP-1-GLP-1-Gs/&β;1/&γ;2
23.53Single6PB0Urocortin6PB0-CRF1-Urocortin-chim(NtGi1-Gs)/&β;1/&γ;2
23.53Single7RBTTirzepatide7RBT-GIP-Tirzepatide-PubChem 163183774-chim(NtGi1-Gs)/&β;1/&γ;2
23.53Single7TS0Urocortin7TS0-CRF2-Urocortin-chim(NtGi1L-Go)/&β;1/&γ;2
23.53Consensusgip_onOrthosteric Ligand7DTY-GIP-GIP-Gs/&β;1/&γ;2 7VAB-GIP-Non-Acylated Tirzepatide-chim(NtGi1-Gs)/&β;1/&γ;2 7FIN-GIP-Peptide-20; GGL-Gs/&β;1/&γ;2 7FIY-GIP-Tirzepatide-Gs/&β;1/&γ;2
23.53Consensusgip_on_alloOrthosteric Ligand7RBT-GIP-Tirzepatide-PubChem 163183774-chim(NtGi1-Gs)/&β;1/&γ;2
23.33Single7FINPeptide-20; GGL7FIN-GIP-Peptide-20; GGL-Gs/&β;1/&γ;2
23.33Single7RYCOxytocin7RYC-OT-Oxytocin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
23.33Consensusbk2_onOrthosteric Ligand7F2O-BK2-Bradykinin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7F6I-BK2-Kallidin-Gq/&β;1/&γ;2
23.33Consensusgo_class-bOrthosteric Ligandgo_class-b1 go_class-b2
23.08Single4BUONeurotensin4BUO-NTS1-Neurotensin
23.08Single4NC3Ergotamine4NC3-5-HT2B-Ergotamine
23.08Single5TUDErgotamine5TUD-5-HT2B-Ergotamine
23.08Single6BQGErgotamine6BQG-5-HT2C-Ergotamine
23.08Single7EVZCenerimod7EVZ-S1P1-Cenerimod-Gi1/&β;1/&γ;2
23.08Single7EW0Ozanimod7EW0-S1P1-Ozanimod-Gi1/&β;1/&γ;2
23.08Single7EZCUKA7EZC-A2A-UKA
23.08Single7JVRBromoergocryptine7JVR-D2-Bromoergocryptine-Gi1/&β;1/&γ;2
23.08Single7MBYCholecystokinin-87MBY-CCKA-Cholecystokinin-8-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
23.08Single7SK8CCX6627SK8-ACKR3-CXCL12-CCX662
23.08Single7WVVfMLFII7WVV-FPR2-ALX-fMLFII-Gi2/&β;1/&γ;2
23.08Single7XJISolabegron7XJI-β3-Solabegron-Gs/&β;1/&γ;2
23.08Single8IYSTUG-8918IYS-FFA4-TUG-891-GDP-chim(NtGi1L-Gq)/&β;1/&γ;2
23.08Single8XJOU466198XJO-TP-U46619-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
23.08Consensusbileacid_onOrthosteric Ligand7CFN-GPBA-INT-777-Gs/&β;1/&γ;2 7CFM-GPBA-P395-Gs/&β;1/&γ;2 7XTQ-GPBA-R399-Gs/&β;1/&γ;2
23.08Consensusendothelin_offOrthosteric Ligandetb_off
23.08Consensusep4_onOrthosteric Ligand7D7M-EP4-Dinoprostone-Gs/&β;1/&γ;1 8GCP-EP4-PGE2-Gi1/&β;1/&γ;2 8GD9-EP4-Rivenprost-Gs/&β;1/&γ;2 8GDA-EP4-L902688-Gs/&β;1/&γ;2
23.08Consensusetb_offOrthosteric Ligand5XPR-ETB-Bosentan 6K1Q-ETB-IRL2500 5X93-ETB-K-8794
23.08Consensussteroid_onOrthosteric Ligandbileacid_on
22.86Single7SK6CXCL12_LRHQ7SK6-ACKR3-CXCL12_LRHQ
22.73Single4MBSMaraviroc4MBS-CCR5-Maraviroc
22.73Single6IQLL7458706IQL-D4-L745870
22.73Single6ME32-Phenylmelatonin6ME3-MT1-2-Phenylmelatonin
22.73Single6ME42-Iodomelatonin6ME4-MT1-2-Iodomelatonin
22.73Single6MH8ZM2413856MH8-A2A-ZM241385
22.73Single6V9SGTPL114036V9S-OX1-GTPL11403
22.73Single6ZDVPubChem 9840736ZDV-A2A-PubChem 984073-Na
22.73Single7AROLUF58337ARO-A2A-LUF5833-Na
22.73Single7SR8TAK-9257SR8-OX2-TAK-925-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
22.73Single7T32ZM2413857T32-A2A-ZM241385
22.73Single7XOVSR1461317XOV-CCKA-SR146131-Gs/&β;1/&γ;2
22.73Single8GCML9026888GCM-EP4-L902688-Gi1/&β;1/&γ;2
22.73Single8GDZEpinephrine8GDZ-β2-Epinephrine-Gs/&β;1/&γ;2
22.73Single8GGTEpinephrine8GGT-β2-Epinephrine
22.73Single8HNMVUF112228HNM-CXCR3-VUF11222-Gi1/&β;1/&γ;2
22.73Single8K2WAMG4878K2W-CXCR3-AMG487
22.73Single8UO2Epinephrine8UO2-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
22.73Single8W88SEP-3638568W88-TA1-SEP-363856-Gs/&β;1/&γ;2
22.73Consensuscb1_offOrthosteric Ligand5TGZ-CB1-AM6538 5U09-CB1-Taranabant
22.73Consensuscxcr2_onOrthosteric Ligand6LFM-CXCR2-Interleukin-8-Gi1/&β;1/&γ;2
22.73Consensuscxcr_onOrthosteric Ligandcxcr1_on cxcr2_on
22.73Consensusghrelin_offOrthosteric Ligand6KO5-Ghrelin-PubChem 57400002 7F83-Ghrelin-PF-05190457
22.73Consensusnop_offOrthosteric Ligand4EA3-NOP-PubChem 10296561 5DHG-NOP-PubChem 25001412 5DHH-NOP-SB-612111
22.73Consensusox2_offOrthosteric Ligand6TPN-OX2-HTL6641 7XRR-OX2-Lemborexant
22.58Single7F6HBradykinin7F6H-BK2-Bradykinin-Gq/&β;1/&γ;2
22.58Single7F6IKallidin7F6I-BK2-Kallidin-Gq/&β;1/&γ;2
22.58Single7KH0Acyclovir triphosphate7KH0-V2-Acyclovir triphosphate-chim(NtGi1-Gs)/&β;1/&γ;2
22.58Single7X9CPancreatic Hormone7X9C-Y4-Pancreatic Hormone-Gi1/&β;1/&γ;2
22.58Single7Y35Abaloparatide7Y35-PTH1-Abaloparatide-Gs/&β;1/&γ;2
22.58Single7YKDChemerin-97YKD-CML1-Chemerin-9-Gi1/&β;1/&γ;2
22.58Single8HCXEndothelin-18HCX-ETB-Endothelin-1-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
22.58Single8IODPG-9018IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
22.22Single3NY9PubChem 9131033NY9-β2-PubChem 913103
22.22Single5EE7MK08935EE7-Glucagon-MK0893
22.22Single7F2OBradykinin7F2O-BK2-Bradykinin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
22.22Single7S8LCortistatin-147S8L-MRGPRX2-Cortistatin-14-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
22.22Single7SK9CCX6627SK9-ACKR3-CCX662
22.22Single7W2ZGhrelin7W2Z-Ghrelin-Ghrelin-Go/&β;1/&γ;2
22.22Single7XN9L-054,5227XN9-SST2-L-054,522
22.22Single7YAEOctreotide7YAE-SST2-Octreotide-Gi1/&β;1/&γ;2
22.22Single8GEJEpinephrine8GEJ-β2-Epinephrine-Gs/&β;1/&γ;2
22.22Single8H4IDoconexent8H4I-FFA4-Doconexent-chim(NtGi1-Gs)/&β;1/&γ;2
22.22Single8JIPMEDI03828JIP-GLP-1-MEDI0382-chim(NtGi1-Gs)/&β;1/&γ;2
22.22Single8XZFWN5618XZF-Apelin-WN561-Gi1/&β;1/&γ;2
22.22Consensusclass-d_offOrthosteric Ligandste2_off
22.22Consensusfpr1-alx_onOrthosteric Ligand7VFX-FPR1-ALX-fMLF-Gi1/&β;1/&γ;2 7T6T-FPR1-ALX-fMLFII-Gi1/&β;1/&γ;2
22.22Consensusfpr2-alx_onOrthosteric Ligand7WVY-FPR2-ALX-Amyloid-Beta42-Gi2/&β;1/&γ;2 7T6U-FPR2-ALX-CGEN-855A-Gi1/&β;1/&γ;2 7WVV-FPR2-ALX-fMLFII-Gi2/&β;1/&γ;2 7WVW-FPR2-ALX-fMYFINILTL-Gi2/&β;1/&γ;2 7WVX-FPR2-ALX-Humanin-Gi2/&β;1/&γ;2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/&β;1/&γ;2 6OMM-FPR2-ALX-WKYMVX-Gi1/&β;1/&γ;2
22.22Consensusgo_ghrelinOrthosteric Ligand7W2Z-Ghrelin-Ghrelin-Go/&β;1/&γ;2
22.22Consensusgs_bombesinOrthosteric Ligand8H0Q-BB2-Gastrin Releasing Peptide-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8H0P-BB1-NMB30-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
21.88Single6P9YPACAP6P9Y-PAC1-PACAP-Gs/&β;1/&γ;2
21.88Single7W57Neuromedin-S7W57-NMUR2-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
21.88Single7XV3Lysophosphatidylserine7XV3-GPR174-Lysophosphatidylserine-chim(NtGi1-Gs)/&β;1/&γ;2
21.88Consensusglp1_on_alloOrthosteric Ligand6VCB-GLP-1-GLP-1-LSN3160440-Gs/&β;1/&γ;2
21.74Single2Y02Carmoterol2Y02-β1-Carmoterol
21.74Single2Y04Salbutamol2Y04-β1-Salbutamol
21.74Single4J4QOctyl Beta-D-Glucopyranoside4J4Q-Rhodopsin-Octyl Beta-D-Glucopyranoside-Gt(CT)
21.74Single4QKXPubChem 762106284QKX-β2-PubChem 76210628
21.74Single5DHGPubChem 250014125DHG-NOP-PubChem 25001412
21.74Single5OLZPubChem 1355666095OLZ-A2A-PubChem 135566609-Na
21.74Single5OM1PubChem 1355666095OM1-A2A-PubChem 135566609-Na
21.74Single5TGZAM65385TGZ-CB1-AM6538
21.74Single5UENDU1725UEN-A1-DU172
21.74Single6DRXLisuride6DRX-5-HT2B-Lisuride
21.74Single6DRZMethysergide6DRZ-5-HT2B-Methysergide
21.74Single6GPSMK08126GPS-CCR2-MK0812
21.74Single6IIVDaltroban6IIV-TP-Daltroban
21.74Single6PS1Timolol6PS1-β2-Timolol
21.74Single6PS82-Phenylmelatonin6PS8-MT1-2-Phenylmelatonin
21.74Single6TOTLemborexant6TOT-OX1-Lemborexant
21.74Single6Z4VNTS8-136Z4V-NTS1-NTS8-13
21.74Single7CRHSKF839597CRH-D1-SKF83959-Gs/&β;1/&γ;2
21.74Single7S15PubChem 1346112237S15-GLP-1-PubChem 134611223
21.74Single7SCGFH2107SCG-μ-FH210-Gi1/&β;1/&γ;2
21.74Single7SQOTAK-9257SQO-OX2-TAK-925-Gi1/&β;1/&γ;2
21.74Single7T2GMitragynine pseudoindoxyl7T2G-μ-Mitragynine pseudoindoxyl-Gi1/&β;1/&γ;2
21.74Single7UL4Alvimopan7UL4-μ-Alvimopan
21.74Single7VGZRemalteon7VGZ-MT1-Remalteon-Gi1/&β;1/&γ;2
21.74Single7XJHIsoproterenol7XJH-β3-Isoproterenol-Gs/&β;1/&γ;2
21.74Single8CICEtrumadenant8CIC-A2A-Etrumadenant-Na
21.74Single8CU7LJ-45178CU7-A2A-LJ-4517-Na
21.74Single8EFQDamgo8EFQ-μ-Damgo-Gi1/&β;1/&γ;2
21.74Single8GEBEpinephrine8GEB-β2-Epinephrine-Gs/&β;1/&γ;2
21.74Single8GEHEpinephrine8GEH-β2-Epinephrine-Gs/&β;1/&γ;2
21.74Single8IC0Interleukin-88IC0-CXCR1-Interleukin-8-Gi1/&β;1/&γ;2
21.74Single8W8ARO52563908W8A-TA1-RO5256390-chim(NtGi1L-Gs)/&β;1/&γ;2
21.74Consensusadenosine_onOrthosteric Liganda1_on a2_on
21.74Consensusd5_onOrthosteric Ligand8IRV-D5-Rotigotine-chim(NtGi1-Gs)/&β;1/&γ;2
21.74Consensusnucleotide_onOrthosteric Ligandadenosine_on
21.74Consensustp_offOrthosteric Ligand6IIV-TP-Daltroban 6IIU-TP-Ramatroban
21.62Consensuspth2_onOrthosteric Ligand7F16-PTH2-TIP39-Gs/&β;1/&γ;2
21.43Single4AMJ(S)-Carvedilol4AMJ-β1-(S)-Carvedilol
21.43Single4IARErgotamine4IAR-5-HT1B-Ergotamine
21.43Single5VBLApelin Mimetic Peptide Agonist5VBL-Apelin-Apelin Mimetic Peptide Agonist
21.43Single7F54Afamelanotide7F54-MC4-Afamelanotide-Gs/&β;1/&γ;2
21.43Single7QA8Peptide7QA8-STE2-Peptide
21.43Single7QA8Peptide7QA8-STE2-Peptide
21.43Single7T6UCGEN-855A7T6U-FPR2-ALX-CGEN-855A-Gi1/&β;1/&γ;2
21.43Single7W53Neuromedin-U-257W53-NMUR1-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
21.43Single7WICSomatostatin-147WIC-SST2-Somatostatin-14-Gi1/&β;1/&γ;2
21.43Single7XMRSomatostatin-147XMR-SST2-Somatostatin-14-Gi1/&β;1/&γ;2
21.43Single8F7XNociceptin8F7X-NOP-Nociceptin-Gi1/&β;1/&γ;2
21.43Single8G59TUG-8918G59-FFA4 (GPR120)-TUG-891-Gi1/&β;1/&γ;2
21.43Single8XBHS3E-LysoPS8XBH-GPR34-S3E-LysoPS-Gi1/&β;1/&γ;2
21.43Consensusclass-d_offOrthosteric Ligandste2_off
21.43Consensussst2_onOrthosteric Ligand7XMR-SST2-Somatostatin-14-Gi1/&β;1/&γ;2 7XAU-SST2-Octreotide-Gi1/&β;1/&γ;2 7YAC-SST2-Paltusotine-Gi1/&β;1/&γ;2
21.21Single5NX2GLP-1 (Truncated)5NX2-GLP-1-GLP-1 (Truncated)
21.21Single6LMKGlucagon6LMK-Glucagon-Glucagon-Gs/&β;1/&γ;2
21.21Single6P9XCorticoliberin6P9X-CRF1-Corticoliberin-Gs/&β;1/&γ;2
21.21Single6UVAAdrenomedullin-26UVA-CT Like (AM2)-Adrenomedullin-2-Gs/&β;1/&γ;2; RAMP3
21.21Consensusgs_cgrpOrthosteric Ligand6E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/&β;1/&γ;2; RAMP1 6UUN-CT Like (AM1)-Adrenomedullin-Gs/&β;1/&γ;2; RAMP2
21.21Consensusste2_onOrthosteric Ligand7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
21.05Single6TQ9SB-4081246TQ9-OX1-SB-408124
21.05Single8A2OTheophylline8A2O-A2A-Theophylline-Na
21.05Single8U4QREGN7663-Fab8U4Q-CXCR4-REGN7663-Fab-Cholesterol-Gi1/&β;1/&γ;2
21.05Consensushca2_on_alloOrthosteric Ligand8J6P-HCA2-Niacin-Compound 9n-Gi1/&β;1/&γ;2 8J6Q-HCA2-Beta-hydroxybutyrate-Compound 9n-Gi1/&β;1/&γ;2
20.83Single2Y00Dobutamine2Y00-β1-Dobutamine
20.83Single2Y03Isoprenaline2Y03-β1-Isoprenaline
20.83Single5N2RPubChem 92460631; psb365N2R-A2A-PubChem 92460631; psb36-Na
20.83Single5NM2ZM2413855NM2-A2A-ZM241385-Na
20.83Single5T1APubChem 68764898; PubChem 120931705T1A-CCR2-PubChem 68764898; PubChem 12093170
20.83Single5WIUNemonapride5WIU-D4-Nemonapride
20.83Single5WIVNemonapride5WIV-D4-Nemonapride-Na
20.83Single6DDEDamgo6DDE-μ-Damgo-Gi1/&β;1/&γ;2
20.83Single6GPXMK08126GPX-CCR2-MK0812
20.83Single6LFMInterleukin-86LFM-CXCR2-Interleukin-8-Gi1/&β;1/&γ;2
20.83Single6ME82-Phenylmelatonin6ME8-MT2-2-Phenylmelatonin
20.83Single7SBFPZM217SBF-μ-PZM21-Gi1/&β;1/&γ;2
20.83Single7VFXfMLF7VFX-FPR1-ALX-fMLF-Gi1/&β;1/&γ;2
20.83Single7VV4Cortistatin-147VV4-MRGPRX2-Cortistatin-14
20.83Single7XKAEpinephrine7XKA-β2-Epinephrine
20.83Single8C9WEtrumadenant8C9W-A2A-Etrumadenant
20.83Single8GDAL9026888GDA-EP4-L902688-Gs/&β;1/&γ;2
20.83Single8GNEKW-63568GNE-A2A-KW-6356-Na
20.83Single8ID9Eicosapentaenoic acid8ID9-FFA4 (GPR120)-Eicosapentaenoic acid-Gi1/&β;1/&γ;2
20.83Single8J19PubChem 1270454228J19-GPR84-PubChem 127045422-Gi1/&β;1/&γ;2
20.83Single8QOTNanobody E8QOT-μ-Nanobody E
20.83Single8UNYEpinephrine8UNY-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
20.83Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
20.83Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
20.83Consensus5ht2b_offOrthosteric Ligand6DRZ-5-HT2B-Methysergide 6DRX-5-HT2B-Lisuride
20.83Consensusa1_offOrthosteric Ligand5UEN-A1-DU172 5N2S-A1-PSB36
20.83Consensusadrenergic_offOrthosteric Ligandbeta_off alpha_off
20.83Consensusbeta3_onOrthosteric Ligand7DH5-β3-Mirabegron-Gs/&β;1/&γ;2 7XJH-β3-Isoproterenol-Gs/&β;1/&γ;2
20.83Consensusccr2_off_alloOther Ligand5T1A-CCR2-PubChem 68764898; PubChem 12093170 6GPX-CCR2-MK0812
20.83Consensusd4_offOrthosteric Ligand5WIU-D4-Nemonapride
20.83Consensusd4_off_alloOrthosteric Ligand5WIV-D4-Nemonapride-Na
20.83Consensusgs_adrenergicOrthosteric Ligand3SN6-β2-BI167107-Gs/&β;1/&γ;2 7DHR-β2-Isoprenaline-Gs/&β;1/&γ;2 7DHI-β2-Salbutamol-Gs/&β;1/&γ;2 7XJH-β3-Isoproterenol-Gs/&β;1/&γ;2 7DH5-β3-Mirabegron-Gs/&β;1/&γ;2 7XJI-β3-Solabegron-Gs/&β;1/&γ;2 8THK-Alpha1A-A61603-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8THL-Alpha1A-Epinephrine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 7JJO-β1-Isoprenaline-Gs/&β;1/&γ;2 8DCR-β1-Dobutamine-Gs/&β;1/&γ;2 7BZ2-β2-Arformoterol-Gs/&β;1/&γ;2
20.83Consensusta1_onOrthosteric Ligand8W87-TA1-METH-chim(NtGi1L-Gs)/&β;1/&γ;2 8W89-TA1-PEA-chim(NtGi1L-Gs)/&β;1/&γ;2 8JLP-TA1-Ralmitaront-Gs/&β;1/&γ;2 8W8A-TA1-RO5256390-chim(NtGi1L-Gs)/&β;1/&γ;2 8W88-TA1-SEP-363856-Gs/&β;1/&γ;2 8JLN-TA1-T1AM-Gs/&β;1/&γ;2 8JLO-TA1-Ulotaront-Gs/&β;1/&γ;2 8JLR-TA1-A77636-chim(NtGi1-Gs)/&β;1/&γ;2 8JSO-TA1-AMPH-chim(NtGi1-Gs)/&β;1/&γ;2 8JLQ-TA1-Fenoldopam-Gs/&β;1/&γ;2 8WCA-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/&β;1/&γ;2
20.69Single4IB4Ergotamine4IB4-5-HT2B-Ergotamine
20.69Single7CUMPhospholipid7CUM-GABAB1, GABAB2-CGP54626-Phospholipid
20.69Single7DDZJNJ-310200287DDZ-Y2-JNJ-31020028
20.69Single7WJ5Somatostatin-147WJ5-SST2-Somatostatin-14-Gi1/&β;1/&γ;2
20.69Single8IBVMotilin8IBV-Motilin-Motilin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
20.69Single8IOCGamma-MSH8IOC-MC3-Gamma-MSH-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
20.69Single8SG1Chemerin-98SG1-CML1-Chemerin-9-Gi1/&β;1/&γ;2
20.69Consensusnpy2_offOrthosteric Ligand7DDZ-Y2-JNJ-31020028
20.69Consensussst_offOrthosteric Ligandsst2_off
20.59Single8FLTM-PTH(1-14)8FLT-PTH1-M-PTH(1-14)-Gs/&β;1/&γ;2
20.59Consensusglp1_onOrthosteric Ligand6X18-GLP-1-GLP-1-Gs/&β;1/&γ;2 6X19-GLP-1-CHU-128-Gs/&β;1/&γ;2 6X1A-GLP-1-Danuglipron-Gs/&β;1/&γ;2 7S1M-GLP-1-Ex4-D-Ala-Gs/&β;1/&γ;2 7LLL-GLP-1-Exendin-4-Gs/&β;1/&γ;2 6B3J-GLP-1-Exendin-P5-Gs/&β;1/&γ;2 8JIP-GLP-1-MEDI0382-chim(NtGi1-Gs)/&β;1/&γ;2 7VBI-GLP-1-Non-Acylated Tirzepatide-Gs/&β;1/&γ;2 6XOX-GLP-1-Orforglipron-chim(NtGi1-Gs)/&β;1/&γ;2 8JIS-GLP-1-Peptide-15-chim(NtGi1-Gs)/&β;1/&γ;2 7RTB-GLP-1-Peptide-19-Gs/&β;1/&γ;2 7VBH-GLP-1-Peptide-20-Gs/&β;1/&γ;2 7C2E-GLP-1-PubChem 149050799-Gs/&β;1/&γ;2 8JIR-GLP-1-SAR425899-chim(NtGi1-Gs)/&β;1/&γ;2 7KI0-GLP-1-Semaglutide-Gs/&β;1/&γ;2 7KI1-GLP-1-Taspoglutide-Gs/&β;1/&γ;2 7FIM-GLP-1-Tirzepatide-Gs/&β;1/&γ;2
20.59Consensussecretin_onOrthosteric Ligand6WZG-Secretin-Secretin-Gs/&β;1/&γ;2
20.00Single2YDVNECA2YDV-A2A-NECA
20.00Single3P0GBI1671073P0G-β2-BI167107
20.00Single3PDSHydroxybenzylisoproterenol3PDS-β2-Hydroxybenzylisoproterenol
20.00Single3ZEVNeurotensin3ZEV-NTS1-Neurotensin
20.00Single4BV0Neurotensin4BV0-NTS1-Neurotensin
20.00Single4LDLHydroxybenzylisoproterenol4LDL-β2-Hydroxybenzylisoproterenol
20.00Single4UHRCGS216804UHR-A2A-CGS21680
20.00Single5A8E7-Methylcyanopindolol5A8E-β1-7-Methylcyanopindolol-Na
20.00Single5G53NECA5G53-A2A-NECA-Gs
20.00Single5TZR-5TZR-FFA1 (GPR40)-MK8666
20.00Single5WKTOctyl Beta-D-Glucopyranoside5WKT-Rhodopsin-Octyl Beta-D-Glucopyranoside-Gt(CT)
20.00Single5X93K-87945X93-ETB-K-8794
20.00Single6H7JIsoprenaline6H7J-β1-Isoprenaline
20.00Single6LI0GTPL98046LI0-GPR52-GTPL9804
20.00Single6ME5Agomelatine6ME5-MT1-Agomelatine
20.00Single6N48BI1671076N48-β2-BI167107-PubChem 138454256
20.00Single6TQ7SB-3348676TQ7-OX1-SB-334867
20.00Single6UP7Neurotensin6UP7-NTS1-Neurotensin-Arrestin2
20.00Single6WGTLSD6WGT-5-HT2A-LSD
20.00Single7E2ZAripiprazole7E2Z-5-HT1A-Aripiprazole-Gi1/&β;1/&γ;2
20.00Single7JJOIsoprenaline7JJO-β1-Isoprenaline-Gs/&β;1/&γ;2
20.00Single7L0PNeurotensin7L0P-NTS1-Neurotensin-Gi1/&β;1/&γ;1
20.00Single7L0QNeurotensin7L0Q-NTS1-Neurotensin-Gi1/&β;1/&γ;1
20.00Single7S8MCortistatin-147S8M-MRGPRX2-Cortistatin-14-Gi1/&β;1/&γ;2
20.00Single7T6TfMLFII7T6T-FPR1-ALX-fMLFII-Gi1/&β;1/&γ;2
20.00Single7TD1LPA7TD1-LPA1-LPA-Gi1/&β;1/&γ;2
20.00Single7U2LPubChem 1632012427U2L-μ-PubChem 163201242-Gi1/&β;1/&γ;2
20.00Single7VGY2-Iodomelatonin7VGY-MT1-2-Iodomelatonin-Gi1/&β;1/&γ;2
20.00Single7W41PD1762527W41-BB2-PD176252
20.00Single7XAUOctreotide7XAU-SST2-Octreotide-Gi1/&β;1/&γ;2
20.00Single7XTQR3997XTQ-GPBA-R399-Gs/&β;1/&γ;2
20.00Single7XWONeurokinin-A7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
20.00Single8DCSCyanopindolol8DCS-β1-Cyanopindolol-Gs/&β;1/&γ;2
20.00Single8FMZNeurotensin/neuromedin N8FMZ-NTS1-Neurotensin/neuromedin N-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
20.00Single8G056-OAU8G05-GPR84-6-OAU-Gi1/&β;1/&γ;2
20.00Single8GDBPGE28GDB-EP4-PGE2-Gs/&β;1/&γ;2
20.00Single8GGREpinephrine8GGR-β2-Epinephrine
20.00Single8ID39-Hydroxystearic acid8ID3-FFA4 (GPR120)-9-Hydroxystearic acid-Gi1/&β;1/&γ;2
20.00Single8ID6Oleic acid8ID6-FFA4 (GPR120)-Oleic acid-Gi1/&β;1/&γ;2
20.00Single8IRURotigotine8IRU-D4-Rotigotine-chim(NtGi1-Gs-CtGi1)/&β;1/&γ;2
20.00Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/&β;1/&γ;2
20.00Single8X16Piclidenoson8X16-A3A-Piclidenoson-Gi1/&β;1/&γ;2
20.00Consensus5ht1b_onOrthosteric Ligand6G79-5-HT1B-Donitriptan-Go/&β;1/&γ;2
20.00Consensus5ht5_offOrthosteric Ligand5ht5a_off
20.00Consensusa2_onOrthosteric Liganda2a_on a2b_on
20.00Consensusa2b_onOrthosteric Ligand8HDP-A2B-Adenosine-Gs/&β;1/&γ;2 8HDO-A2B-BAY 60-6583-Gs/&β;1/&γ;2 7XY7-A2B-NECA-chim(NtGi1-Gs)/&β;1/&γ;2 7XY6-A2B-PubChem 11717831-chim(NtGi1-Gs)/&β;1/&γ;2
20.00Consensusadenosine_offOrthosteric Liganda1_off a2_off
20.00Consensusbb2_offOrthosteric Ligand7W41-BB2-PD176252
20.00Consensusbombesin_offOrthosteric Ligandbb2_off
20.00Consensuschemerin_onOrthosteric Ligandcml1_on
20.00Consensuscml1_onOrthosteric Ligand8SG1-CML1-Chemerin-9-Gi1/&β;1/&γ;2
20.00Consensusdopamine_offOrthosteric Ligandd3_off d2_off d4_off
20.00Consensusffa4_onOrthosteric Ligand8H4K-FFA4-GW9508-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8ID9-FFA4 (GPR120)-Eicosapentaenoic acid-Gi1/&β;1/&γ;2 8ID4-FFA4 (GPR120)-Linoleic acid-Gi1/&β;1/&γ;2 8ID6-FFA4 (GPR120)-Oleic acid-Gi1/&β;1/&γ;2 8G59-FFA4 (GPR120)-TUG-891-Gi1/&β;1/&γ;2 8ID3-FFA4 (GPR120)-9-Hydroxystearic acid-Gi1/&β;1/&γ;2 8H4I-FFA4-Doconexent-chim(NtGi1-Gs)/&β;1/&γ;2
20.00Consensusgi_chemerinOrthosteric Ligand8SG1-CML1-Chemerin-9-Gi1/&β;1/&γ;2
20.00Consensusgi_ffaOrthosteric Ligand8ID6-FFA4 (GPR120)-Oleic acid-Gi1/&β;1/&γ;2 8G59-FFA4 (GPR120)-TUG-891-Gi1/&β;1/&γ;2 8ID3-FFA4 (GPR120)-9-Hydroxystearic acid-Gi1/&β;1/&γ;2 8ID9-FFA4 (GPR120)-Eicosapentaenoic acid-Gi1/&β;1/&γ;2 8ID4-FFA4 (GPR120)-Linoleic acid-Gi1/&β;1/&γ;2 8J22-FFA2-TUG-1375-Gi1/&β;1/&γ;2 8J24-FFA2-Acetic acid-Gi1/&β;1/&γ;2 8J21-FFA3-Butyric acid-Gi1/&β;1/&γ;2
20.00Consensusgi_muscarinicOrthosteric Ligand7TRS-M4-Acetylcholine-Gi1/&β;1/&γ;2 7TRK-M4-Iperoxo-Gi1/&β;1/&γ;2 7V6A-M4-PubChem 9864275-Gi1/&β;1/&γ;2
20.00Consensusgs_adenosineOrthosteric Ligand8HDP-A2B-Adenosine-Gs/&β;1/&γ;2 8HDO-A2B-BAY 60-6583-Gs/&β;1/&γ;2 6GDG-A2A-NECA-Gs/&β;1/&γ;1 7XY7-A2B-NECA-chim(NtGi1-Gs)/&β;1/&γ;2 7XY6-A2B-PubChem 11717831-chim(NtGi1-Gs)/&β;1/&γ;2
20.00Consensusgs_nucleotideOrthosteric Ligandgs_adenosine
20.00Consensuss1p2_onOrthosteric Ligand7T6B-S1P2-S1P-chim(NtGi1L-G13)/&β;1/&γ;2
20.00Consensussst4_onOrthosteric Ligand7XMT-SST4-J-2156-Gi1/&β;1/&γ;2
19.35Single8HNKCXCL118HNK-CXCR3-CXCL11-Gi1/&β;1/&γ;2
19.35Consensuspca1_onOrthosteric Ligand6M1I-PAC1-PACAP-Gs/&β;1/&γ;2
19.35Consensusste2_onOrthosteric Ligand7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
19.23Single2YCXCyanopindolol2YCX-β1-Cyanopindolol
19.23Single4AMIBucindolol4AMI-β1-Bucindolol
19.23Single4GRVNeurotensin 8-134GRV-NTS1-Neurotensin 8-13
19.23Single4LDEBI1671074LDE-β2-BI167107
19.23Single4PY02MeSATP4PY0-P2Y12-2MeSATP
19.23Single5F8UCyanopindolol5F8U-β1-Cyanopindolol
19.23Single5X33BIIL2605X33-BLT1-BIIL260
19.23Single6DRYMethylergonovine6DRY-5-HT2B-Methylergonovine
19.23Single6TKOArformoterol6TKO-β1-Arformoterol-Arrestin2
19.23Single7L0SNeurotensin7L0S-NTS1-Neurotensin-Gi1/&β;1/γ1
19.23Single7T6BS1P7T6B-S1P2-S1P-chim(NtGi1L-G13)/&β;1/&γ;2
19.23Single7WCMMBX-29827WCM-GPR119-MBX-2982-Gs/&β;1/&γ;2
19.23Single7XMTJ-21567XMT-SST4-J-2156-Gi1/&β;1/&γ;2
19.23Single7XW9TRH7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
19.23Single7XZ5Lysophosphatidylcholine7XZ5-GPR119-Lysophosphatidylcholine-Gs/&β;1/&γ;2
19.23Single7Y24Octreotide7Y24-SST2-Octreotide-Go/&β;1/&γ;2
19.23Single8H0QGastrin Releasing Peptide8H0Q-BB2-Gastrin Releasing Peptide-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
19.23Single8IRSRotigotine8IRS-D2-Rotigotine-Gi1/&β;1/&γ;2
19.23Single8JJ8Formoterol8JJ8-β2-Formoterol
19.23Single8JPBNeurotensin 8-138JPB-NTS1-Neurotensin 8-13-PubChem 118610427; GDP; Mg-Gq; GRK2
19.23Consensusbeta1_onOrthosteric Ligand7JJO-β1-Isoprenaline-Gs/&β;1/&γ;2 8DCR-β1-Dobutamine-Gs/&β;1/&γ;2
19.23Consensusep_onOrthosteric Ligandep4_on ep2_on ep3_on
19.23Consensusgo_5htOrthosteric Ligand6G79-5-HT1B-Donitriptan-Go/&β;1/&γ;2 7UM5-5-HT5A-5-CT-chim(NtGi1-Go)/&β;1/&γ;2 7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/&β;1/&γ;2 7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/&β;1/&γ;2
19.23Consensusgs_amineOrthosteric Ligandgs_5ht gs_adrenergic gs_dopamine gs_histamine gs_muscarinic gs_tar
19.23Consensusgs_trhOrthosteric Ligand7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
19.23Consensusm4_onOrthosteric Ligand7TRS-M4-Acetylcholine-Gi1/&β;1/&γ;2 7TRK-M4-Iperoxo-Gi1/&β;1/&γ;2 8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/&β;1/&γ;2 7V6A-M4-PubChem 9864275-Gi1/&β;1/&γ;2
19.23Consensustrh_onOrthosteric Ligand7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
19.05Single5OLVLUAA410635OLV-A2A-LUAA41063-Na
19.05Single7XT9Serotonin7XT9-5-HT4-Serotonin-Gs/&β;1/&γ;2
19.05Single8A2PLUAA470708A2P-A2A-LUAA47070-Na
19.05Single8GEIEpinephrine8GEI-β2-Epinephrine-Gs/&β;1/&γ;2
19.05Single8GGSEpinephrine8GGS-β2-Epinephrine
19.05Single8JSOAMPH8JSO-TA1-AMPH-chim(NtGi1-Gs)/&β;1/&γ;2
19.05Single8U4RREGN7663-Fab8U4R-CXCR4-REGN7663-Fab-Cholesterol
19.05Single8UNVEpinephrine8UNV-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
19.05Consensusmt2_onOrthosteric Ligand7VH0-MT2-Ramelteon-Gi1/&β;1/&γ;1
18.92Single8JIRSAR4258998JIR-GLP-1-SAR425899-chim(NtGi1-Gs)/&β;1/&γ;2
18.92Consensuspth1_onOrthosteric Ligand8FLQ-PTH1-PTH-Gs/&β;1/&γ;2 8FLR-PTH1-PTHrP(1-36)-Gs/&β;1/&γ;2 7Y36-PTH1-Teriparatide-Gs/&β;1/&γ;2 7Y35-PTH1-Abaloparatide-Gs/&β;1/&γ;2 8FLU-PTH1-Long-acting PTH-Gs/&β;1/&γ;2 6NBF-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2 7VVM-PTH1-PTH-Gs/&β;1/&γ;2
18.75Single7QBIAlpha-factor mating pheromone7QBI-STE2-Alpha-factor mating pheromone
18.75Single7WBJPACAP277WBJ-VPAC1-PACAP27-Gs/&β;1/&γ;2
18.75Consensusvpac1_onOrthosteric Ligand8E3Y-VPAC1-PACAP27-Gs/&β;1/&γ;2 8E3Z-VPAC1-VIP-Gs/&β;1/&γ;2 6VN7-VPAC1-PACAP-Gs/&β;1/&γ;2
18.52Single2YCZIodocyanopindolol2YCZ-β1-Iodocyanopindolol
18.52Single4BVNCyanopindolol4BVN-β1-Cyanopindolol-Na
18.52Single4PXZ2MeSADP4PXZ-P2Y12-2MeSADP
18.52Single5TZYMK8666; PubChem 1270535975TZY-FFA1 (GPR40)-MK8666; PubChem 127053597
18.52Single6G79Donitriptan6G79-5-HT1B-Donitriptan-Go/&β;1/&γ;2
18.52Single6H7LDobutamine6H7L-β1-Dobutamine
18.52Single6IBLArformoterol6IBL-β1-Arformoterol
18.52Single6K1QIRL25006K1Q-ETB-IRL2500
18.52Single7CX4Evatanepag7CX4-EP2-Evatanepag-Gs/&β;1/&γ;2
18.52Single7MTSADX551647MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/&β;1/&γ;2
18.52Single7U2KC6-guano7U2K-μ-C6-guano-Gi1/&β;1/&γ;2
18.52Single7UM4AS26747237UM4-5-HT5A-AS2674723
18.52Single7XAVLanreotide7XAV-SST2-Lanreotide-Gi1/&β;1/&γ;2
18.52Single8IULLatanoprost8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
18.52Single8JPFNeurotensin8JPF-NTS1-Neurotensin-PubChem 118610427
18.52Consensus5ht5a_offOrthosteric Ligand7UM4-5-HT5A-AS2674723
18.52Consensusadgrg2_onOrthosteric Ligand7XKD-ADGRG2-Betahydroxyandrosterone-Gs/&β;1/&γ;2 7WUI-ADGRG2-IP15-chim(NtGi1-Gs)/&β;1/&γ;2
18.52Consensusbeta1_off_alloOrthosteric Ligand4BVN-β1-Cyanopindolol-Na
18.52Consensusep2_onOrthosteric Ligand7CX4-EP2-Evatanepag-Gs/&β;1/&γ;2 7CX2-EP2-PGE2-Gs/&β;1/&γ;2 7CX3-EP2-Taprenepag-Gs/&β;1/&γ;2
18.52Consensusgi_neurotensinOrthosteric Ligand7L0P-NTS1-Neurotensin-Gi1/&β;1/&γ;1 6OS9-NTS1-JMV449-Gi1/&β;1/&γ;2
18.52Consensusgs_lipidOrthosteric Ligandgs_ffa gs_prostanoid
18.52Consensusgs_prostanoidOrthosteric Ligand8IUK-FP-alpha-PGF2-alpha-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7CX2-EP2-PGE2-Gs/&β;1/&γ;2 7CX3-EP2-Taprenepag-Gs/&β;1/&γ;2 7D7M-EP4-Dinoprostone-Gs/&β;1/&γ;1 7CX4-EP2-Evatanepag-Gs/&β;1/&γ;2 8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
18.52Consensusnk2_onOrthosteric Ligand7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
18.42Single8JITMEDI03828JIT-Glucagon-MEDI0382-Gs/&β;1/&γ;2
18.18Single4BWBNeurotensin4BWB-NTS1-Neurotensin
18.18Single4S0VSuvorexant4S0V-OX2-Suvorexant
18.18Single5K2DZM2413855K2D-A2A-ZM241385
18.18Single5OLOTozadenant5OLO-A2A-Tozadenant-Na
18.18Single5WS3EMPA5WS3-OX2-EMPA
18.18Single6B73PubChem 1319551386B73-κ-PubChem 131955138
18.18Single6JZHZM2413856JZH-A2A-ZM241385-Na
18.18Single6KUXRS-799486KUX-α2a-RS-79948
18.18Single6NWEOctyl Beta-D-Glucopyranoside6NWE-Rhodopsin-Octyl Beta-D-Glucopyranoside-Gt(CT)
18.18Single6OBA(S)-Alprenolol6OBA-β2-(S)-Alprenolol-GTPL11074
18.18Single6PS7ZM2413856PS7-A2A-ZM241385-Na
18.18Single6TPJSuvorexant6TPJ-OX2-Suvorexant
18.18Single7BR3Elagolix7BR3-GnRH1-Elagolix
18.18Single7F8YDevazepide7F8Y-CCKA-Devazepide
18.18Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
18.18Single7QBIAlpha-factor mating pheromone7QBI-STE2-Alpha-factor mating pheromone
18.18Single7TUZ7alpha,25-dihydroxycholesterol7TUZ-GPR183-7alpha,25-dihydroxycholesterol-Gi1/&β;1/&γ;2
18.18Single7VDLCortistatin-147VDL-MRGPRX2-Cortistatin-14-Gi1/&β;1/&γ;2
18.18Single7W0MPubChem 1227019087W0M-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
18.18Single7XT8Serotonin7XT8-5-HT4-Serotonin-Gs/&β;1/&γ;2
18.18Single7YMHNorepinephrine7YMH-Alpha1A-Norepinephrine-chim(Gs-CtGq)/&β;1/&γ;2
18.18Single8DU3PubChem 1055260648DU3-A2A-PubChem 105526064
18.18Single8FLRPTHrP(1-36)8FLR-PTH1-PTHrP(1-36)-Gs/&β;1/&γ;2
18.18Single8GECEpinephrine8GEC-β2-Epinephrine-Gs/&β;1/&γ;2
18.18Single8GEFEpinephrine8GEF-β2-Epinephrine-Gs/&β;1/&γ;2
18.18Single8GG7Epinephrine8GG7-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
18.18Single8GGAEpinephrine8GGA-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
18.18Single8GGFEpinephrine8GGF-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
18.18Single8GGVEpinephrine8GGV-β2-Epinephrine
18.18Single8GGWEpinephrine8GGW-β2-Epinephrine
18.18Single8GGXEpinephrine8GGX-β2-Epinephrine
18.18Single8GH0Epinephrine8GH0-β2-Epinephrine
18.18Single8HMPPubChem 699214798HMP-GPR52-PubChem 69921479-Gs/&β;1/&γ;2
18.18Single8IW4Spermidine8IW4-TAAR9-Spermidine-chim(NtGi1-Gs)/&β;1/&γ;2
18.18Single8IWESpermidine8IWE-TAAR9-Spermidine
18.18Single8SZGCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-chim(NtGi1-Gq)/&β;1/&γ;2
18.18Single8UNOEpinephrine8UNO-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
18.18Single8UO0Epinephrine8UO0-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
18.18Single8UO1Epinephrine8UO1-β2-Epinephrine-GTP; Mg-Gs/&β;1/&γ;2
18.18Single8WC4ZH86518WC4-TA1-ZH8651-chim(NtGi1-Gs)/&β;1/&γ;2
18.18Single8WCA2-Phenylethylamine8WCA-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/&β;1/&γ;2
18.18Consensusa2a_off_alloOrthosteric Ligand6ZDR-A2A-HMS1413f12-Na 6GT3-A2A-Imaradenant-Na 8CU7-A2A-LJ-4517-Na 5OLV-A2A-LUAA41063-Na 5N2R-A2A-PubChem 92460631; psb36-Na 5MZJ-A2A-Theophylline-Na 5OLO-A2A-Tozadenant-Na 5OLH-A2A-Vipadenant-Na 5NM4-A2A-ZM241385-Na 8GNE-A2A-KW-6356-Na 8JWZ-A2A-AB928-Na 5MZP-A2A-Caffeine-Na 8CIC-A2A-Etrumadenant-Na
18.18Consensusalpha2_offOrthosteric Ligandalpha2a_off alpha2c_off
18.18Consensusalpha2a_offOrthosteric Ligand6KUX-α2a-RS-79948
18.18Consensusbeta2_off_alloOrthosteric Ligand6OBA-β2-(S)-Alprenolol-GTPL11074
18.18Consensusclass-d_onOrthosteric Ligandste2_on
18.18Consensusgnrh1_offOrthosteric Ligand7BR3-GnRH1-Elagolix
18.18Consensusmelatonin_onOrthosteric Ligandmt1_on mt2_on
18.18Consensusorexin_offOrthosteric Ligandox2_off ox1_off
18.18Consensusp2y_offOrthosteric Ligandp2y1_off p2y12_off
17.86Single5WF6UK-4320975WF6-A2A-UK-432097
17.86Single6OMMWKYMVX6OMM-FPR2-ALX-WKYMVX-Gi1/&β;1/&γ;2
17.86Single7MTRADX551647MTR-mGlu2; mGlu2-Glutamate-ADX55164
17.86Single7NA7Ghrelin-277NA7-Ghrelin-Ghrelin-27-Gi1/&β;1/&γ;2
17.86Single8INRAlpha-MSH8INR-MC5-Alpha-MSH-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
17.86Single8X5YAstemizole8X5Y-H1-Astemizole
17.65Single7AD3Alpha-factor mating pheromone7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
17.65Single7QBCAlpha-factor mating pheromone7QBC-STE2-Alpha-factor mating pheromone
17.65Consensusgi_class-dOrthosteric Ligandgi_ste
17.65Consensusgi_steOrthosteric Ligand7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
17.65Consensusglp2_onOrthosteric Ligand7D68-GLP-2-GLP-2-Gs/&β;1/&γ;2
17.39Single2YDOAdenosine2YDO-A2A-Adenosine
17.39Single3REYPubChem 56973REY-A2A-PubChem 5697
17.39Single3UZCPubChem 1355666093UZC-A2A-PubChem 135566609
17.39Single4LDOL-Epinephrine4LDO-β2-L-Epinephrine
17.39Single4ZJCSB-6740424ZJC-OX1-SB-674042
17.39Single5IU4ZM2413855IU4-A2A-ZM241385-Na
17.39Single5IU7Q274563465IU7-A2A-Q27456346-Na
17.39Single5IUBQ274563445IUB-A2A-Q27456344-Na
17.39Single5JTBZM2413855JTB-A2A-ZM241385
17.39Single5K2BZM2413855K2B-A2A-ZM241385-Na
17.39Single5K2CZM2413855K2C-A2A-ZM241385-Na
17.39Single5NLXZM2413855NLX-A2A-ZM241385-Na
17.39Single5NM4ZM2413855NM4-A2A-ZM241385-Na
17.39Single5TE3Octyl Beta-D-Glucopyranoside5TE3-Rhodopsin-Octyl Beta-D-Glucopyranoside
17.39Single6AQFZM2413856AQF-A2A-ZM241385
17.39Single6DS0Ly2660976DS0-5-HT2B-Ly266097
17.39Single6PS4ICI 118-5516PS4-β2-ICI 118-551
17.39Single6PS5(S)-Propranolol6PS5-β2-(S)-Propranolol
17.39Single6TOSGSK10598656TOS-OX1-GSK1059865-Na
17.39Single6TP3Nemorexant6TP3-OX1-Nemorexant
17.39Single6TPGEMPA6TPG-OX2-EMPA
17.39Single6VI4JDTic6VI4-κ-JDTic
17.39Single6ZA8RTI-3a6ZA8-NTS1-RTI-3a
17.39Single6ZDRHMS1413f126ZDR-A2A-HMS1413f12-Na
17.39Single7BB6Acyclovir triphosphate7BB6-V2-Acyclovir triphosphate-Gs/&β;1/&γ;2
17.39Single7DHISalbutamol7DHI-β2-Salbutamol-Gs/&β;1/&γ;2
17.39Single7JOZVFP7JOZ-D1-VFP-Gs/&β;1/&γ;2
17.39Single7S8PMS471347S8P-MRGPRX4-MS47134-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
17.39Single7VUGJNJ-635330547VUG-GPR139-JNJ-63533054-Gi1/&β;1/&γ;2
17.39Single7WC9PubChem 1624213647WC9-5-HT2A-PubChem 162421364
17.39Single8DWGML3828DWG-MRGPRX1-Proenkephalin-A-ML382-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
17.39Single8GE1Epinephrine8GE1-β2-Epinephrine-Gs/&β;1/&γ;2
17.39Single8GE4Epinephrine8GE4-β2-Epinephrine-Gs/&β;1/&γ;2
17.39Single8GE6Epinephrine8GE6-β2-Epinephrine-Gs/&β;1/&γ;2
17.39Single8GE7Epinephrine8GE7-β2-Epinephrine-Gs/&β;1/&γ;2
17.39Single8GE8Epinephrine8GE8-β2-Epinephrine-Gs/&β;1/&γ;2
17.39Single8GE9Epinephrine8GE9-β2-Epinephrine-Gs/&β;1/&γ;2
17.39Single8GEGEpinephrine8GEG-β2-Epinephrine-Gs/&β;1/&γ;2
17.39Single8GFVEpinephrine8GFV-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
17.39Single8GG4Epinephrine8GG4-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
17.39Single8GG8Epinephrine8GG8-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
17.39Single8GGIEpinephrine8GGI-β2-Epinephrine
17.39Single8GGKEpinephrine8GGK-β2-Epinephrine
17.39Single8GGMEpinephrine8GGM-β2-Epinephrine
17.39Single8GGPEpinephrine8GGP-β2-Epinephrine
17.39Single8GGQEpinephrine8GGQ-β2-Epinephrine
17.39Single8JLKUlotaront8JLK-TA1-Ulotaront-chim(NtGi1-Gs)/&β;1/&γ;2
17.39Single8JLNT1AM8JLN-TA1-T1AM-Gs/&β;1/&γ;2
17.39Single8UHBRO52563908UHB-TA1-RO5256390-Gs/&β;1/&γ;2
17.39Single8UNQEpinephrine8UNQ-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
17.39Single8UNZEpinephrine8UNZ-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
17.39Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
17.39Consensus5ht2a_offOrthosteric Ligand6A94-5-HT2A-Zotepine 6WH4-5-HT2A-Methiothepin 7VOE-5-HT2A-Aripiprazole 7VOD-5-HT2A-Cariprazine 7WC8-5-HT2A-Lumateperone 6A93-5-HT2A-Risperidone
17.39Consensusffa2_onOrthosteric Ligand8J24-FFA2-Acetic acid-Gi1/&β;1/&γ;2 8T3S-FFA2-Butyric acid-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8J22-FFA2-TUG-1375-Gi1/&β;1/&γ;2
17.39Consensusgi_melatoninOrthosteric Ligand7VGY-MT1-2-Iodomelatonin-Gi1/&β;1/&γ;2 7DB6-MT1-Ramelteon-Gi1/&β;1/&γ;2 7VH0-MT2-Ramelteon-Gi1/&β;1/&γ;1
17.39Consensusgnrh_offOrthosteric Ligandgnrh1_off
17.39Consensusgs_tarOrthosteric Ligand8W88-TA1-SEP-363856-Gs/&β;1/&γ;2 8JLN-TA1-T1AM-Gs/&β;1/&γ;2 8JLO-TA1-Ulotaront-Gs/&β;1/&γ;2 8JLQ-TA1-Fenoldopam-Gs/&β;1/&γ;2 8JLP-TA1-Ralmitaront-Gs/&β;1/&γ;2 8WCA-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/&β;1/&γ;2 8WCB-TA1-Cyclohexylammonium ion-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8WC8-TA1-ZH8651-chim(NtGi1-Gs)/&β;1/&γ;2
17.39Consensuslh_on_alloOther Ligand7FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/&β;1/&γ;2
17.39Consensusox1_offOrthosteric Ligand6TOT-OX1-Lemborexant 6TP4-OX1-ACT-462206 6TP6-OX1-Filorexant 6V9S-OX1-GTPL11403 6TP3-OX1-Nemorexant 6TQ6-OX1-PubChem 145714283 6TQ7-OX1-SB-334867 6TQ9-OX1-SB-408124 4ZJC-OX1-SB-674042 4ZJ8-OX1-Suvorexant
17.24Single7CX3Taprenepag7CX3-EP2-Taprenepag-Gs/&β;1/&γ;2
17.24Single7RTBPeptide-197RTB-GLP-1-Peptide-19-Gs/&β;1/&γ;2
17.24Single8IZBLysophosphatidylserine8IZB-GPR174-Lysophosphatidylserine-Gs/&β;1/&γ;2
17.14Single7QBCAlpha-factor mating pheromone7QBC-STE2-Alpha-factor mating pheromone
17.14Consensuscrf1_onOrthosteric Ligand6P9X-CRF1-Corticoliberin-Gs/&β;1/&γ;2
16.67Single2VT4Cyanopindolol2VT4-β1-Cyanopindolol
16.67Single2Y01Dobutamine2Y01-β1-Dobutamine
16.67Single2YCYCyanopindolol2YCY-β1-Cyanopindolol
16.67Single3EMLZM2413853EML-A2A-ZM241385
16.67Single3NY8ICI 118-5513NY8-β2-ICI 118-551
16.67Single3NYA(S)-Alprenolol3NYA-β2-(S)-Alprenolol
16.67Single3ZPQ4-(piperazin-1- yl)-1H-indole3ZPQ-β1-4-(piperazin-1- yl)-1H-indole-Na
16.67Single3ZPR4-methyl-2-(piperazin-1-yl)3ZPR-β1-4-methyl-2-(piperazin-1-yl)-Na
16.67Single4EIYZM2413854EIY-A2A-ZM241385-Na
16.67Single4GBR(S)-Carazolol4GBR-β2-(S)-Carazolol
16.67Single4QIMPubChem 249053754QIM-SMO-PubChem 24905375
16.67Single5IU8Q274563475IU8-A2A-Q27456347-Na
16.67Single5JQH(S)-Carazolol5JQH-β2-(S)-Carazolol
16.67Single5K2AZM2413855K2A-A2A-ZM241385-Na
16.67Single5OLGZM2413855OLG-A2A-ZM241385-Na
16.67Single5T04Neurotensin5T04-NTS1-Neurotensin
16.67Single5VRAZM2413855VRA-A2A-ZM241385-Na
16.67Single6H7MSalbutamol6H7M-β1-Salbutamol
16.67Single6HLOAprepitant6HLO-NK1-Aprepitant
16.67Single6LPJZM2413856LPJ-A2A-ZM241385-Na
16.67Single6LPKZM2413856LPK-A2A-ZM241385-Na
16.67Single6PRZ(S)-Alprenolol6PRZ-β2-(S)-Alprenolol
16.67Single6PS0(S)-Carazolol6PS0-β2-(S)-Carazolol
16.67Single6PS2(S)-Alprenolol6PS2-β2-(S)-Alprenolol
16.67Single6S0LZM2413856S0L-A2A-ZM241385
16.67Single6XBM25(S)-Epoxycholesterol6XBM-SMO-25(S)-Epoxycholesterol-Gi1/&β;1/&γ;2
16.67Single7BTSL-Epinephrine7BTS-β1-L-Epinephrine
16.67Single7BU6L-Norepinephrine7BU6-β1-L-Norepinephrine
16.67Single7BU7BI1671077BU7-β1-BI167107
16.67Single7CUMPhospholipid7CUM-GABAB1, GABAB2-CGP54626-Phospholipid
16.67Single7F83PF-051904577F83-Ghrelin-PF-05190457
16.67Single7FIHOrg435537FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/&β;1/&γ;2
16.67Single7JVQApomorphine7JVQ-D1-Apomorphine-Gs/&β;1/&γ;2
16.67Single7LJCPubChem 867641037LJC-D1-PubChem 86764103-Mevidalen-Gs/&β;1/&γ;2
16.67Single7PYRPSB-21157PYR-A2A-PSB-2115
16.67Single7S0GIsoprenaline7S0G-β1-Isoprenaline-chim(Gi1-CtGs)/&β;1/&γ;2
16.67Single7SK8CXCL127SK8-ACKR3-CXCL12-CCX662
16.67Single7UM6Lisuride7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/&β;1/&γ;2
16.67Single7VH0Ramelteon7VH0-MT2-Ramelteon-Gi1/&β;1/&γ;1
16.67Single7VKTLTB47VKT-BLT1-LTB4-Gi1/&β;1/&γ;2
16.67Single7WC7Lisuride7WC7-5-HT2A-Lisuride
16.67Single8EJCTAK-8758EJC-FFA1 (GPR40)-TAK-875-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
16.67Single8EJKTAK-8758EJK-FFA1 (GPR40)-TAK-875-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
16.67Single8GE3Epinephrine8GE3-β2-Epinephrine-Gs/&β;1/&γ;2
16.67Single8GEEEpinephrine8GEE-β2-Epinephrine-Gs/&β;1/&γ;2
16.67Single8GFWEpinephrine8GFW-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
16.67Single8GFXEpinephrine8GFX-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
16.67Single8GFYEpinephrine8GFY-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
16.67Single8GFZEpinephrine8GFZ-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
16.67Single8GG0Epinephrine8GG0-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
16.67Single8GG1Epinephrine8GG1-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
16.67Single8GG2Epinephrine8GG2-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
16.67Single8GG6Epinephrine8GG6-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
16.67Single8GGBEpinephrine8GGB-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
16.67Single8GGJEpinephrine8GGJ-β2-Epinephrine
16.67Single8GGNEpinephrine8GGN-β2-Epinephrine
16.67Single8GGOEpinephrine8GGO-β2-Epinephrine
16.67Single8GGUEpinephrine8GGU-β2-Epinephrine
16.67Single8ID4Linoleic acid8ID4-FFA4 (GPR120)-Linoleic acid-Gi1/&β;1/&γ;2
16.67Single8IRTRotigotine8IRT-D3-Rotigotine-Gi1/&β;1/&γ;2
16.67Single8J18(3R)-3-hydroxydodecanoic acid8J18-GPR84-(3R)-3-hydroxydodecanoic acid-Gi1/&β;1/&γ;2
16.67Single8JJOAlprenolol8JJO-β2-Alprenolol
16.67Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/&β;1/&γ;2
16.67Single8UNMEpinephrine8UNM-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
16.67Single8UNNEpinephrine8UNN-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
16.67Single8UNPEpinephrine8UNP-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
16.67Single8UO4Epinephrine8UO4-β2-Epinephrine-GTP; Mg-Gs/&β;1/&γ;2
16.67Single8W87METH8W87-TA1-METH-chim(NtGi1L-Gs)/&β;1/&γ;2
16.67Single8WCCCyclohexylammonium ion8WCC-TA1-Cyclohexylammonium ion
16.67Single8XJLPGF2-alpha8XJL-FP-alpha-PGF2-alpha-chim(NtGi2-Gs-CtGq)/&β;1/&γ;2
16.67Consensus5ht1a_onOrthosteric Ligand8JSP-5-HT1A-Ulotaront-Gi1/&β;1/&γ;2 7E2Z-5-HT1A-Aripiprazole-Gi1/&β;1/&γ;2 8W8B-5-HT1A-SEP-363856-Gi1/&β;1/&γ;2 7E2Y-5-HT1A-Serotonin-Gi1/&β;1/&γ;2
16.67Consensus5ht2_offOrthosteric Ligand5ht2a_off 5ht2b_off 5ht2c_off
16.67Consensusa2_offOrthosteric Liganda2a_off
16.67Consensusa2a_offOrthosteric Ligand8C9W-A2A-Etrumadenant 3UZA-A2A-GTPL9236 8GNG-A2A-Istradefylline 5UIG-A2A-J3.651.884G 8CU6-A2A-LJ-4517 7PX4-A2A-PSB-2113 7PYR-A2A-PSB-2115 8DU3-A2A-PubChem 105526064 8JWY-A2A-PubChem 168451710 5K2D-A2A-ZM241385
16.67Consensusadrenergic_onOrthosteric Ligandbeta_on alpha_on
16.67Consensusamine_onOrthosteric Ligandadrenergic_on histamine_on muscarinic_on tar_on 5ht_on dopamine_on
16.67Consensusblt1_onOrthosteric Ligand7VKT-BLT1-LTB4-Gi1/&β;1/&γ;2
16.67Consensusblt_onOrthosteric Ligandblt1_on
16.67Consensuscck_offOrthosteric Ligandccka_off
16.67Consensusccka_offOrthosteric Ligand7F8Y-CCKA-Devazepide 7F8U-CCKA-Lintitript
16.67Consensusdopamine_onOrthosteric Ligandd3_on d2_on d5_on d1_on
16.67Consensusfsh_on_alloOther Ligand8I2G-FSH-Glycoprotein hormones alpha chain-Compound 716340-Gs/&β;1/&γ;2
16.67Consensusgi_leukotrieneOrthosteric Ligand7VKT-BLT1-LTB4-Gi1/&β;1/&γ;2
16.67Consensusleuko_onOrthosteric Ligandblt_on
16.67Consensussmo_offOrthosteric Ligand5L7I-SMO-Vismodegib 4O9R-SMO-Cyclopamine 4QIM-SMO-PubChem 24905375 4JKV-SMO-Taladegib (LY2940680)
16.67Consensustar_onOrthosteric Ligandta1_on
16.67Consensusvasopressin-ot_onOrthosteric Ligandot_on v2_on
16.28Consensusgs_calcitoninOrthosteric Ligandgs_ct gs_cgrp
16.00Single2RH1(S)-Carazolol2RH1-β2-(S)-Carazolol
16.00Single2YCW(S)-Carazolol2YCW-β1-(S)-Carazolol
16.00Single4JKVTaladegib (LY2940680)4JKV-SMO-Taladegib (LY2940680)
16.00Single4PHUFasiglifam4PHU-FFA1 (GPR40)-Fasiglifam
16.00Single4ZJ8Suvorexant4ZJ8-OX1-Suvorexant
16.00Single5D6L(S)-Carazolol5D6L-β2-(S)-Carazolol
16.00Single5IUAQ274563485IUA-A2A-Q27456348-Na
16.00Single5TVNLSD5TVN-5-HT2B-LSD
16.00Single5WQCEMPA5WQC-OX2-EMPA
16.00Single5X7D(S)-Carazolol5X7D-β2-(S)-Carazolol-PubChem 129318963
16.00Single5XPRBosentan5XPR-ETB-Bosentan
16.00Single5ZK3Quinuclidinyl benzilate hydrobromide5ZK3-M2-Quinuclidinyl benzilate hydrobromide
16.00Single6E67BI1671076E67-β2-BI167107-Gs (fused)
16.00Single6GDGNECA6GDG-A2A-NECA-Gs/&β;1/&γ;1
16.00Single6KUWPubChem 572132346KUW-α2c-PubChem 57213234
16.00Single6LPLZM2413856LPL-A2A-ZM241385-Na
16.00Single6LUQHaloperidol6LUQ-D2-Haloperidol
16.00Single6M9TMisoprostol-FA6M9T-EP3-Misoprostol-FA
16.00Single6PS3(S)-Carvedilol6PS3-β2-(S)-Carvedilol
16.00Single6PS6Timolol6PS6-β2-Timolol
16.00Single6S0QZM2413856S0Q-A2A-ZM241385
16.00Single6TO7Suvorexant6TO7-OX1-Suvorexant-Na
16.00Single6TP6Filorexant6TP6-OX1-Filorexant
16.00Single6W2XPubChem 237279706W2X-GABAB1, GABAB2-PubChem 5311042-PubChem 23727970
16.00Single6WQAZM2413856WQA-A2A-ZM241385-Na
16.00Single6XBKCholesterol6XBK-SMO-Cholesterol-Gi1/&β;1/&γ;2
16.00Single6Z8NSRI-98296Z8N-NTS1-SRI-9829
16.00Single7BVQ(S)-Carazolol7BVQ-β1-(S)-Carazolol
16.00Single7RM5ZM2413857RM5-A2A-ZM241385-Na
16.00Single7S0FIsoprenaline7S0F-β1-Isoprenaline-Gi1/&β;1/&γ;2
16.00Single7SINNPS-21437SIN-CaS-NPS-2143
16.00Single7SINNPS-21437SIN-CaS-NPS-2143
16.00Single7T9NPubChem 6440787T9N-TSH-M22 Fab-PubChem 644078-Gs/&β;1/&γ;2
16.00Single7VOEAripiprazole7VOE-5-HT2A-Aripiprazole
16.00Single7VUHJNJ-635330547VUH-GPR139-JNJ-63533054-chim(Gs-CtGq)/&β;1/&γ;2
16.00Single7WIGL-054,2647WIG-SST2-L-054,264-Gi1/&β;1/&γ;2
16.00Single7Y26Octreotide7Y26-SST2-Octreotide-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
16.00Single7Y27Somatostatin-147Y27-SST2-Somatostatin-14-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
16.00Single8FYNZM2413858FYN-A2A-ZM241385-Na
16.00Single8GD9Rivenprost8GD9-EP4-Rivenprost-Gs/&β;1/&γ;2
16.00Single8GDCPGE28GDC-EP3-PGE2-Gi1/&β;1/&γ;2
16.00Single8SZGCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-chim(NtGi1-Gq)/&β;1/&γ;2
16.00Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/&β;1/&γ;2
16.00Consensusa2a_onOrthosteric Ligand6GDG-A2A-NECA-Gs/&β;1/&γ;1
16.00Consensusalpha2c_offOrthosteric Ligand6KUW-α2c-PubChem 57213234
16.00Consensusamine_offOrthosteric Ligandadrenergic_off histamine_off muscarinic_off 5ht_off dopamine_off
16.00Consensusbeta2_offOrthosteric Ligand6PS2-β2-(S)-Alprenolol 6PS3-β2-(S)-Carvedilol 6PS5-β2-(S)-Propranolol 6PS6-β2-Timolol 2RH1-β2-(S)-Carazolol 6PS4-β2-ICI 118-551 3NY9-β2-PubChem 913103
16.00Consensusbeta2_onOrthosteric Ligand3SN6-β2-BI167107-Gs/&β;1/&γ;2 7DHR-β2-Isoprenaline-Gs/&β;1/&γ;2 7BZ2-β2-Arformoterol-Gs/&β;1/&γ;2 7DHI-β2-Salbutamol-Gs/&β;1/&γ;2
16.00Consensusbeta_offOrthosteric Ligandbeta1_off beta2_off
16.00Consensusbeta_onOrthosteric Ligandbeta1_on beta2_on beta3_on
16.00Consensusep3_onOrthosteric Ligand8GDC-EP3-PGE2-Gi1/&β;1/&γ;2
16.00Consensusgi_adrenergicOrthosteric Ligand7S0F-β1-Isoprenaline-Gi1/&β;1/&γ;2 6K42-α2b-Dexmedetomidine-Gi1/&β;1/&γ;2
16.00Consensusgs_sstOrthosteric Ligand7Y27-SST2-Somatostatin-14-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
15.79Single5MZJTheophylline5MZJ-A2A-Theophylline-Na
15.79Single7V68PubChem 576644067V68-M4-Iperoxo-PubChem 57664406-Gi1/&β;1/&γ;2
15.79Single7WC4Serotonin7WC4-5-HT2A-Serotonin
15.79Single7XKEBetahydroxyandrosterone7XKE-ADGRG2-Betahydroxyandrosterone-chim(NtGi1-Gs)/&β;1/&γ;2
15.79Single8PWNTheophylline8PWN-A2A-Theophylline
15.62Single6NIYAdrenomedullin6NIY-CT-Adrenomedullin-Gs/&β;1/&γ;2
15.62Single7AD3Alpha-factor mating pheromone7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
15.62Consensusclass-d_onOrthosteric Ligandste2_on
15.62Consensusgi_class-dOrthosteric Ligandgi_ste
15.62Consensusgi_steOrthosteric Ligand7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
15.38Single3UONQuinuclidinyl benzilate hydrobromide3UON-M2-Quinuclidinyl benzilate hydrobromide
15.38Single5D5A(S)-Carazolol5D5A-β2-(S)-Carazolol
15.38Single5D5B(S)-Carazolol5D5B-β2-(S)-Carazolol
15.38Single5V56TC1145V56-SMO-TC114
15.38Single5V57TC1145V57-SMO-TC114
15.38Single6J20Aprepitant6J20-NK1-Aprepitant
15.38Single6J21Aprepitant6J21-NK1-Aprepitant
15.38Single7R0CAcyclovir triphosphate7R0C-V2-Acyclovir triphosphate-Arrestin2
15.38Single7SK7CXCL127SK7-ACKR3-CXCL12-CCX662
15.38Single7W6PW967W6P-α2a-W96-Go/&β;1/&γ;2
15.38Single7W7EW587W7E-α2a-W58-Go/&β;1/&γ;2
15.38Single8I2GCompound 7163408I2G-FSH-Glycoprotein hormones alpha chain-Compound 716340-Gs/&β;1/&γ;2
15.38Single8IRRRotigotine8IRR-D1-Rotigotine-Gs/&β;1/&γ;2
15.38Single8JLPRalmitaront8JLP-TA1-Ralmitaront-Gs/&β;1/&γ;2
15.38Single8JXVClozapine8JXV-H4-Clozapine-Gi1/&β;1/&γ;2
15.38Single8JXWVUF68848JXW-H4-VUF6884-Gi1/&β;1/&γ;2
15.38Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
15.38Single8XBIS3E-LysoPS8XBI-GPR34-S3E-LysoPS
15.38Single8XJMLatanoprost8XJM-FP-alpha-Latanoprost-chim(NtGi2-Gs-CtGq)/&β;1/&γ;2
15.38Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/&β;1/&γ;2
15.38Consensus5ht_offOrthosteric Ligand5ht2_off 5ht5_off 5ht1_off
15.38Consensusbeta1_offOrthosteric Ligand2VT4-β1-Cyanopindolol 2YCZ-β1-Iodocyanopindolol
15.38Consensuscyslt1_off_ortoalloOrthosteric Ligand6RZ5-CysLT1-Zafirlukast-Na 6RZ4-CysLT1-Pranlukast-Na
15.38Consensusgi_amineOrthosteric Ligandgi_5ht gi_adrenergic gi_dopamine gi_muscarinic gi_histamine
15.38Consensusgs_ffaOrthosteric Ligand8EIT-FFA1 (GPR40)-Doconexent-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2 8EJC-FFA1 (GPR40)-TAK-875-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2 8H4K-FFA4-GW9508-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8T3V-FFA1-DHA-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8T3S-FFA2-Butyric acid-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8T3Q-FFA4-DHA-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8GD9-EP4-Rivenprost-Gs/&β;1/&γ;2 8GDA-EP4-L902688-Gs/&β;1/&γ;2 8GDB-EP4-PGE2-Gs/&β;1/&γ;2
15.38Consensusnpy_offOrthosteric Ligandnpy2_off npy1_off
15.38Consensusnts1_on_alloOrthosteric Ligand8JPB-NTS1-Neurotensin 8-13-PubChem 118610427; GDP; Mg-Gq; GRK2
15.15Consensuscrf2_onOrthosteric Ligand7TS0-CRF2-Urocortin-chim(NtGi1L-Go)/&β;1/&γ;2
15.00Single3RFMCaffeine3RFM-A2A-Caffeine
15.00Single6OT025(S)-Epoxycholesterol6OT0-SMO-25(S)-Epoxycholesterol-Gi1/&β;1/&γ;2
15.00Single7XKDBetahydroxyandrosterone7XKD-ADGRG2-Betahydroxyandrosterone-Gs/&β;1/&γ;2
15.00Single8DPHLorcaserin8DPH-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
14.81Single3D4STimolol Maleate3D4S-β2-Timolol Maleate
14.81Single3VW7Vorapaxar; Na3VW7-PAR1-Vorapaxar; Na
14.81Single6CM4Risperidone6CM4-D2-Risperidone
14.81Single6H7N(S)-Xamoterol6H7N-β1-(S)-Xamoterol
14.81Single6H7OCyanopindolol6H7O-β1-Cyanopindolol
14.81Single6W2YPubChem 237279706W2Y-GABAB1; GABAB1-PubChem 5311042-PubChem 23727970
14.81Single7D7MDinoprostone7D7M-EP4-Dinoprostone-Gs/&β;1/&γ;1
14.81Single7EXDLasmiditan7EXD-5-HT1F-Lasmiditan-Gi1/&β;1/&γ;2
14.81Single7L1UOrexin7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
14.81Single7XW5ML1097XW5-TSH-TSH-ML109-Gs/&β;1/&γ;2
14.81Single7XXI2MeSADP7XXI-P2Y12-2MeSADP-Gi2/&β;1/&γ;2
14.81Single7XY7NECA7XY7-A2B-NECA-chim(NtGi1-Gs)/&β;1/&γ;2
14.81Single8J22TUG-13758J22-FFA2-TUG-1375-Gi1/&β;1/&γ;2
14.81Single8T3QDHA8T3Q-FFA4-DHA-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
14.81Single8WRBLysophosphatidylserine8WRB-GPR34-Lysophosphatidylserine-Gi1/&β;1/&γ;2
14.81Consensus5ht1f_onOrthosteric Ligand7EXD-5-HT1F-Lasmiditan-Gi1/&β;1/&γ;2
14.81Consensusadgrg_onOrthosteric Ligandadgrg2_on adgrg3_on
14.81Consensusclass-b2_onOrthosteric Ligandadgrg_on
14.81Consensusnts1_onOrthosteric Ligand6OS9-NTS1-JMV449-Gi1/&β;1/&γ;2
14.81Consensusnts_onOrthosteric Ligandnts1_on
14.81Consensusprostanoid_onOrthosteric Ligandep_on fpa_on
14.81Consensustsh_on_alloOther Ligand7XW5-TSH-TSH-ML109-Gs/&β;1/&γ;2
14.71Consensusghrh_onOrthosteric Ligand7CZ5-GHRH-Somatoliberin-Gs/&β;1/&γ;2
14.29Single2J4Y11-cis-Retinal2J4Y-Rhodopsin-11-cis-Retinal
14.29Single4XNWMRS25004XNW-P2Y1-MRS2500
14.29Single6BQHRitanserin6BQH-5-HT2C-Ritanserin
14.29Single6FUFAll-trans-retinal6FUF-Rhodopsin-All-trans-retinal-Go/&β;1/&γ;2
14.29Single6M1HMaxadilan6M1H-PAC1-Maxadilan-Gs/&β;1/&γ;2
14.29Single6ME9Ramelteon6ME9-MT2-Ramelteon
14.29Single6OS9JMV4496OS9-NTS1-JMV449-Gi1/&β;1/&γ;2
14.29Single7CX2PGE27CX2-EP2-PGE2-Gs/&β;1/&γ;2
14.29Single7F23Dopamine7F23-D1-Dopamine-GDP-Gs/&β;1/&γ;2
14.29Single7WC5Psilocin7WC5-5-HT2A-Psilocin
14.29Single8E9X2-Deoxycytidine8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/&β;1/&γ;2
14.29Single8F76-8F76-OR51E2-Gs/&β;1/&γ;2
14.29Single8FX5Xanomeline8FX5-M4-Xanomeline-Xanomeline-Gi1/&β;1/&γ;2
14.29Single8GGZEpinephrine8GGZ-β2-Epinephrine
14.29Single8ID8TUG-8918ID8-FFA4 (GPR120)-TUG-891-Gi1/&β;1/&γ;2
14.29Single8IQ6Latanoprost8IQ6-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
14.29Single8J24Acetic acid8J24-FFA2-Acetic acid-Gi1/&β;1/&γ;2
14.29Single8JRVGlucagon8JRV-Glucagon-Glucagon-Arrestin2
14.29Single8JXTHistamine8JXT-H4-Histamine-PO4-Gi1/&β;1/&γ;2
14.29Single8T3OTUG-8918T3O-FFA4-TUG-891-2Y5-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
14.29Single8WC62-Phenylethylamine8WC6-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/&β;1/&γ;2
14.29Single8WC9ZH86518WC9-TA1-ZH8651-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
14.29Consensus5ht2c_offOrthosteric Ligand6BQH-5-HT2C-Ritanserin
14.29Consensusffa4_on_alloOrthosteric Ligand8T3O-FFA4-TUG-891-2Y5-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
14.29Consensusfpa_onOrthosteric Ligand8IUK-FP-alpha-PGF2-alpha-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
14.29Consensusot_onOrthosteric Ligand7QVM-OT-Oxytocin-chim(NtGi1-Go-CtGq)/&β;1/&γ;2
14.29Consensusp2y1_offOrthosteric Ligand4XNW-P2Y1-MRS2500
14.29Consensussmo_off_alloOrthosteric Ligand6D32-SMO-Cyclopamine-Cyclopamine
13.95Consensusglu_onOrthosteric Ligand6LMK-Glucagon-Glucagon-Gs/&β;1/&γ;2 6WPW-Glucagon-Glucagon derivative ZP3780-Gs/&β;1/&γ;2 8JIT-Glucagon-MEDI0382-Gs/&β;1/&γ;2 8JIQ-Glucagon-Peptide-15-Gs/&β;1/&γ;2 7V35-Glucagon-Peptide-20-Gs/&β;1/&γ;2 8JIU-Glucagon-SAR425899-Gs/&β;1/&γ;2 6WHC-Glucagon-Glu16 analog of GCG-Gs/&β;1/&γ;2
13.79Single6KNMJN241-96KNM-Apelin-JN241-9
13.79Single6PT3DPI-2876PT3-δ-DPI-287
13.79Single8IQ4Carboprost8IQ4-FP-alpha-Carboprost-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
13.79Single8IUMTafluprost acid8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
13.79Consensusgo_vasopressinOrthosteric Ligand7QVM-OT-Oxytocin-chim(NtGi1-Go-CtGq)/&β;1/&γ;2
13.79Consensusgs_adgrOrthosteric Ligand7XKD-ADGRG2-Betahydroxyandrosterone-Gs/&β;1/&γ;2 7WUI-ADGRG2-IP15-chim(NtGi1-Gs)/&β;1/&γ;2
13.79Consensusgs_class-b2Orthosteric Ligandgs_adgr
13.64Single3PBLEticlopride3PBL-D3-Eticlopride
13.64Single5TE520-Methanoretinal5TE5-Rhodopsin-20-Methanoretinal
13.64Single6HLLCP999946HLL-NK1-CP99994
13.64Single6TQ4PubChem 160468446TQ4-OX1-PubChem 16046844-Na
13.64Single7EJKOxymetazoline7EJK-α2a-Oxymetazoline-Go/&β;1/&γ;2
13.64Single7SRQLSD7SRQ-5-HT2B-LSD
13.64Single7VUIJNJ-635330547VUI-GPR139-JNJ-63533054-GTP-chim(Gs-CtGq)/&β;1/&γ;2
13.64Single7XKFBetahydroxyandrosterone7XKF-ADGRG2-Betahydroxyandrosterone-Gs/&β;1/&γ;2
13.64Single7XP6Strychnine7XP6-T2R46-Strychnine-chim(Gs-CtGt3)/&β;1/&γ;2
13.64Single7XTASerotonin7XTA-5-HT4-Serotonin-Gi1/&β;1/&γ;2
13.64Single7YFCHistamine7YFC-H4-Histamine-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
13.64Single7YFDImetit7YFD-H4-Imetit-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
13.64Single7YS6Serotonin7YS6-5-HT6-Serotonin-chim(NtGi1-Gs)/&β;1/&γ;2
13.64Single8DPFLorcaserin8DPF-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
13.64Single8EF6Morphine8EF6-μ-Morphine-Gi1/&β;1/&γ;2
13.64Single8GGYEpinephrine8GGY-β2-Epinephrine
13.64Single8HN8Histamine8HN8-H4-Histamine-Gi1/&β;1/&γ;2
13.64Single8ITFDMCHA8ITF-TAAR9-DMCHA-chim(NtGi1-Gs)/&β;1/&γ;2
13.64Single8JLOUlotaront8JLO-TA1-Ulotaront-Gs/&β;1/&γ;2
13.64Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
13.64Single8UNXEpinephrine8UNX-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
13.64Single8W89PEA8W89-TA1-PEA-chim(NtGi1L-Gs)/&β;1/&γ;2
13.64Single8WC3SEP-3638568WC3-TA1-SEP-363856-chim(NtGi1-Gs)/&β;1/&γ;2
13.64Consensus5ht4_onOrthosteric Ligand7XT8-5-HT4-Serotonin-Gs/&β;1/&γ;2
13.64Consensusclass-t_onOrthosteric Ligandtaste2_on
13.64Consensusd3_offOrthosteric Ligand3PBL-D3-Eticlopride
13.64Consensusgo_chemokineOrthosteric Ligand6WWZ-CCR6-CCL20-Go/&β;1/&γ;2
13.64Consensusgo_proteinOrthosteric Ligandgo_chemokine
13.64Consensusgs_class-tOrthosteric Ligandgs_taste
13.64Consensusgs_tasteOrthosteric Ligand7XP6-T2R46-Strychnine-chim(Gs-CtGt3)/&β;1/&γ;2
13.64Consensusmt1_onOrthosteric Ligand7VGY-MT1-2-Iodomelatonin-Gi1/&β;1/&γ;2 7DB6-MT1-Ramelteon-Gi1/&β;1/&γ;2
13.64Consensusox1_off_alloOrthosteric Ligand6TOD-OX1-EMPA-Na 6TOS-OX1-GSK1059865-Na 6TQ4-OX1-PubChem 16046844-Na 6TO7-OX1-Suvorexant-Na
13.64Consensussmo_on_alloOrthosteric Ligand6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
13.64Consensustaste2_onOrthosteric Ligand7XP6-T2R46-Strychnine-chim(Gs-CtGt3)/&β;1/&γ;2
13.33Single6WIVPubChem 52923113; PubChem 529246456WIV-GABAB1, GABAB2-PubChem 52923113; PubChem 52924645
13.04Single1F8811-cis-Retinal1F88-Rhodopsin-11-cis-Retinal
13.04Single2Z7311-cis-Retinal2Z73-Rhodopsin-11-cis-Retinal
13.04Single3AYN9-cis-Retinal3AYN-Rhodopsin-9-cis-Retinal
13.04Single3VG9ZM2413853VG9-A2A-ZM241385-Antibody
13.04Single5OLHVipadenant5OLH-A2A-Vipadenant-Na
13.04Single6D9HAdenosine6D9H-A1-Adenosine-Gi2/&β;1/&γ;2
13.04Single6KUYPubChem 1457046436KUY-α2a-PubChem 145704643
13.04Single6ME2Ramelteon6ME2-MT1-Ramelteon
13.04Single6OYAAll-trans-retinal6OYA-Rhodopsin-All-trans-retinal-Gt/&β;1/&γ;1
13.04Single6PWCNeurotensin6PWC-NTS1-Neurotensin-Arrestin2
13.04Single6TODEMPA6TOD-OX1-EMPA-Na
13.04Single6WWZCCL206WWZ-CCR6-CCL20-Go/&β;1/&γ;2
13.04Single7DHRIsoprenaline7DHR-β2-Isoprenaline-Gs/&β;1/&γ;2
13.04Single7EJ0L-Norepinephrine7EJ0-α2a-L-Norepinephrine-Go/&β;1/&γ;2
13.04Single7F1ODopamine7F1O-D1-Dopamine-GDP; Mg-Gs/&β;1/&γ;2
13.04Single7F8ULintitript7F8U-CCKA-Lintitript
13.04Single7M3ECa; Ca; Tryptophan; NPS-2143; PO47M3E-CaS-Ca; Ca; Tryptophan; NPS-2143; PO4
13.04Single7M3ECa; Ca; Tryptophan; NPS-2143; PO47M3E-CaS-Ca; Ca; Tryptophan; NPS-2143; PO4
13.04Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
13.04Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
13.04Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
13.04Single7SRRLSD7SRR-5-HT2B-LSD-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
13.04Single7T8XAcetylcholine7T8X-M2-Acetylcholine-chim(NtGi1-Go)/&β;1/&γ;2
13.04Single7T90Acetylcholine7T90-M2-Acetylcholine-chim(NtGi1-Go)/&β;1/&γ;2
13.04Single7VUJJNJ-635330547VUJ-GPR139-JNJ-63533054-GDP-chim(Gs-CtGq)/&β;1/&γ;2
13.04Single7X5H5-CT7X5H-5-HT5A-5-CT-Gi1/&β;1/&γ;2
13.04Single7YM8Oxymetazoline7YM8-Alpha1A-Oxymetazoline-chim(Gs-CtGq)/&β;1/&γ;2
13.04Single8DWHCompound-168DWH-MRGPRX1-Compound-16-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
13.04Single8FN0Neurotensin/neuromedin N8FN0-NTS1-Neurotensin/neuromedin N-PubChem 118610427-chim(NtGi1-Go)/&β;1/&γ;2
13.04Single8GEAEpinephrine8GEA-β2-Epinephrine-Gs/&β;1/&γ;2
13.04Single8GEDEpinephrine8GED-β2-Epinephrine-Gs/&β;1/&γ;2
13.04Single8GG9Epinephrine8GG9-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
13.04Single8HDPAdenosine8HDP-A2B-Adenosine-Gs/&β;1/&γ;2
13.04Single8HOCImetit8HOC-H4-Imetit-Gi1/&β;1/&γ;2
13.04Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
13.04Single8T3SButyric acid8T3S-FFA2-Butyric acid-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
13.04Single8UNLEpinephrine8UNL-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
13.04Single8UNTEpinephrine8UNT-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
13.04Single8UNUEpinephrine8UNU-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
13.04Single8UNWEpinephrine8UNW-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
13.04Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
13.04Consensus5ht2_onOrthosteric Ligand5ht2a_on 5ht2c_on
13.04Consensus5ht_onOrthosteric Ligand5ht1_on 5ht2_on 5ht4_on 5ht5_on 5ht6_on 5ht7_on
13.04Consensusalpha1_onOrthosteric Ligandalpha1a_on
13.04Consensusalpha1a_onOrthosteric Ligand7YMH-Alpha1A-Norepinephrine-chim(Gs-CtGq)/&β;1/&γ;2 7YM8-Alpha1A-Oxymetazoline-chim(Gs-CtGq)/&β;1/&γ;2 8THK-Alpha1A-A61603-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8THL-Alpha1A-Epinephrine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
13.04Consensusccr6_onOrthosteric Ligand6WWZ-CCR6-CCL20-Go/&β;1/&γ;2
13.04Consensusgi_histamineOrthosteric Ligand8HN8-H4-Histamine-Gi1/&β;1/&γ;2 8HOC-H4-Imetit-Gi1/&β;1/&γ;2
13.04Consensusgs_histamineOrthosteric Ligand7YFC-H4-Histamine-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7YFD-H4-Imetit-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
13.04Consensusgt_class-aOrthosteric Ligandgt_opsin
13.04Consensusgt_opsinOrthosteric Ligandgt_sensory
13.04Consensusgt_sensoryOrthosteric Ligand6OYA-Rhodopsin-All-trans-retinal-Gt/&β;1/&γ;1
13.04Consensush4_onOrthosteric Ligand7YFC-H4-Histamine-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7YFD-H4-Imetit-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
13.04Consensusm2_onOrthosteric Ligand7T8X-M2-Acetylcholine-chim(NtGi1-Go)/&β;1/&γ;2
13.04Consensusmglu_onOther Ligandmglu2_on mglu4_on
12.50Single4DKLBeta-funaltrexamine4DKL-μ-Beta-funaltrexamine
12.50Single4MQTIperoxo4MQT-M2-Iperoxo-LY2119620
12.50Single5UVIZM2413855UVI-A2A-ZM241385
12.50Single6A94Zotepine6A94-5-HT2A-Zotepine
12.50Single6K41Dexmedetomidine6K41-α2b-Dexmedetomidine-Go/&β;1/&γ;2
12.50Single6TPNHTL66416TPN-OX2-HTL6641
12.50Single6WH4Methiothepin6WH4-5-HT2A-Methiothepin
12.50Single6WJCAtropine6WJC-M1-Atropine-Muscarinic toxin 7
12.50Single7CKWFenoldopam7CKW-D1-Fenoldopam-Gs/&β;1/&γ;2
12.50Single7CKZDopamine7CKZ-D1-Dopamine-Mevidalen-Gs/&β;1/&γ;2
12.50Single7CMUPramipexole7CMU-D3-Pramipexole-Gi1/&β;1/&γ;2
12.50Single7F0TDopamine7F0T-D1-Dopamine-Gs/&β;1/&γ;2
12.50Single7F1ZDopamine7F1Z-D1-Dopamine-GDP-Gs/&β;1/&γ;2
12.50Single7RANPubChem 1645758477RAN-5-HT2A-PubChem 164575847-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
12.50Single7T94Acetylcholine7T94-M2-Acetylcholine-PubChem 57664406-chim(NtGi1-Go)/&β;1/&γ;2
12.50Single7TRSAcetylcholine7TRS-M4-Acetylcholine-Gi1/&β;1/&γ;2
12.50Single7UM7Methylergometrine7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/&β;1/&γ;2
12.50Single7UTZPubChem 6440787UTZ-TSH-TR1402-PubChem 644078-Gs/&β;1/&γ;2
12.50Single7VVNPTH7VVN-PTH1-PTH-Gs/&β;1/&γ;2
12.50Single8GG3Epinephrine8GG3-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
12.50Single8GG5Epinephrine8GG5-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
12.50Single8GGLEpinephrine8GGL-β2-Epinephrine
12.50Single8JSPUlotaront8JSP-5-HT1A-Ulotaront-Gi1/&β;1/&γ;2
12.50Single8K4NVF08K4N-GPR34-VF0-Gi1/&β;1/&γ;2
12.50Single8T3VDHA8T3V-FFA1-DHA-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
12.50Single8THKA616038THK-Alpha1A-A61603-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
12.50Single8THLEpinephrine8THL-Alpha1A-Epinephrine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
12.50Single8UNREpinephrine8UNR-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
12.50Single8UNSEpinephrine8UNS-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
12.50Single8X7ATreprostinil8X7A-I2-Treprostinil-Gs/&β;1/&γ;2
12.50Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
12.50Consensus5ht2a_onOrthosteric Ligand7RAN-5-HT2A-PubChem 164575847-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 6WHA-5-HT2A-DB13948-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
12.50Consensus5ht5_onOrthosteric Ligand5ht5a_on
12.50Consensus5ht5a_onOrthosteric Ligand7UM5-5-HT5A-5-CT-chim(NtGi1-Go)/&β;1/&γ;2 7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/&β;1/&γ;2 7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/&β;1/&γ;2
12.50Consensusalpha2b_onOrthosteric Ligand6K41-α2b-Dexmedetomidine-Go/&β;1/&γ;2
12.50Consensusd1_on_alloOrthosteric Ligand7LJC-D1-PubChem 86764103-Mevidalen-Gs/&β;1/&γ;2 7CKZ-D1-Dopamine-Mevidalen-Gs/&β;1/&γ;2
12.50Consensusd3_onOrthosteric Ligand8IRT-D3-Rotigotine-Gi1/&β;1/&γ;2 7CMV-D3-PD128907-Gi1/&β;1/&γ;2 7CMU-D3-Pramipexole-Gi1/&β;1/&γ;2
12.50Consensusm1_off_alloOrthosteric Ligand6WJC-M1-Atropine-Muscarinic toxin 7
12.50Consensussensory_offOrthosteric Ligandopsin_off
12.12Single7WUIIP157WUI-ADGRG2-IP15-chim(NtGi1-Gs)/&β;1/&γ;2
12.00Single4DAJTiotropium4DAJ-M3-Tiotropium
12.00Single4EJ4Naltrindole4EJ4-δ-Naltrindole
12.00Single4MQSIperoxo4MQS-M2-Iperoxo
12.00Single4U14Tiotropium4U14-M3-Tiotropium
12.00Single4U16N-Methyl Scopolamine4U16-M3-N-Methyl Scopolamine
12.00Single4X1HNonyl Beta-D-Glucopyranoside4X1H-Rhodopsin-Nonyl Beta-D-Glucopyranoside-Gt(CT)
12.00Single5YC8N-Methyl Scopolamine5YC8-M2-N-Methyl Scopolamine
12.00Single5ZK8N-Methyl Scopolamine5ZK8-M2-N-Methyl Scopolamine
12.00Single5ZKCN-Methyl Scopolamine5ZKC-M2-N-Methyl Scopolamine
12.00Single6K42Dexmedetomidine6K42-α2b-Dexmedetomidine-Gi1/&β;1/&γ;2
12.00Single7CFMP3957CFM-GPBA-P395-Gs/&β;1/&γ;2
12.00Single7DB6Ramelteon7DB6-MT1-Ramelteon-Gi1/&β;1/&γ;2
12.00Single7E32Serotonin7E32-5-HT1D-Serotonin-Gi1/&β;1/&γ;2
12.00Single7EPFNAM5977EPF-mGlu2; mGlu2-NAM597
12.00Single7M3JNPS-2143; PO47M3J-CaS-NPS-2143; PO4
12.00Single7TRPIperoxo7TRP-M4-Iperoxo-LY2033298-Gi1/&β;1/&γ;2
12.00Single7UM55-CT7UM5-5-HT5A-5-CT-chim(NtGi1-Go)/&β;1/&γ;2
12.00Single7WC8Lumateperone7WC8-5-HT2A-Lumateperone
12.00Single7X2CFenoldopam7X2C-D1-Fenoldopam-Fenoldopam-Gs/&β;1/&γ;2
12.00Single7XTC5-CT7XTC-5-HT7-5-CT-Gs/&β;1/&γ;2
12.00Single8DZSGR89,6968DZS-κ-GR89,696-chim(NtGi2-Gz)/&β;1/&γ;2
12.00Single8JLJT1AM8JLJ-TA1-T1AM-chim(NtGi1-Gs)/&β;1/&γ;2
12.00Single8JLZST19368JLZ-5-HT6-ST1936-Gs/&β;1/&γ;2
12.00Single8JT8(R)-IHCH-71798JT8-5-HT2A-(R)-IHCH-7179
12.00Single8WC7ZH86678WC7-TA1-ZH8667-chim(NtGi1-Gs)/&β;1/&γ;2
12.00Single8X63Mepyramine8X63-H1-Mepyramine
12.00Consensus5ht1d_onOrthosteric Ligand7E32-5-HT1D-Serotonin-Gi1/&β;1/&γ;2
12.00Consensus5ht6_onOrthosteric Ligand7XTB-5-HT6-Serotonin-Gs/&β;1/&γ;2 8JLZ-5-HT6-ST1936-Gs/&β;1/&γ;2
12.00Consensus5ht7_onOrthosteric Ligand7XTC-5-HT7-5-CT-Gs/&β;1/&γ;2
12.00Consensusalpha2_onOrthosteric Ligandalpha2a_on alpha2b_on
12.00Consensusalpha_onOrthosteric Ligandalpha1_on alpha2_on
12.00Consensusdop_offOrthosteric Ligand4EJ4-δ-Naltrindole
12.00Consensusffa1_onOrthosteric Ligand8EIT-FFA1 (GPR40)-Doconexent-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2 8EJC-FFA1 (GPR40)-TAK-875-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2 8T3V-FFA1-DHA-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
12.00Consensusffa_onOrthosteric Ligandffa4_on ffa1_on ffa2_on ffa3_on
12.00Consensusgi_5htOrthosteric Ligand7E2Y-5-HT1A-Serotonin-Gi1/&β;1/&γ;2 8JSP-5-HT1A-Ulotaront-Gi1/&β;1/&γ;2 7E32-5-HT1D-Serotonin-Gi1/&β;1/&γ;2 7E33-5-HT1E-BRL-54443-Gi1/&β;1/&γ;2 7EXD-5-HT1F-Lasmiditan-Gi1/&β;1/&γ;2 7XTA-5-HT4-Serotonin-Gi1/&β;1/&γ;2 7X5H-5-HT5A-5-CT-Gi1/&β;1/&γ;2 7E2Z-5-HT1A-Aripiprazole-Gi1/&β;1/&γ;2 8W8B-5-HT1A-SEP-363856-Gi1/&β;1/&γ;2
12.00Consensusgo_muscarinicOrthosteric Ligand8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/&β;1/&γ;2 7T8X-M2-Acetylcholine-chim(NtGi1-Go)/&β;1/&γ;2
12.00Consensusgq_amineOrthosteric Ligandgq_muscarinic gq_histamine
12.00Consensushistamine_onOrthosteric Ligandh1_on h4_on
12.00Consensusm2_on_alloOrthosteric Ligand7T94-M2-Acetylcholine-PubChem 57664406-chim(NtGi1-Go)/&β;1/&γ;2 6OIK-M2-Iperoxo-LY2119620-chim(NtGi1-Go)/&β;1/&γ;2
12.00Consensusm4_on_alloOrthosteric Ligand7TRP-M4-Iperoxo-LY2033298-Gi1/&β;1/&γ;2 7TRQ-M4-Iperoxo-VU0467154-Gi1/&β;1/&γ;2 7V68-M4-Iperoxo-PubChem 57664406-Gi1/&β;1/&γ;2
12.00Consensusmuscarinic_onOrthosteric Ligandm2_on m3_on m4_on m1_on
11.90Consensusct_onOrthosteric Ligand7TYL-CT-Amylin-Gs/&β;1/&γ;2 7TYN-CT-Calcitonin-1-Gs/&β;1/&γ;2 8F0J-CT-Pramlintide analogue san45-Gs/&β;1/&γ;2 6NIY-CT-Adrenomedullin-Gs/&β;1/&γ;2
11.54Single4WW3All-trans-retinal4WW3-Rhodopsin-All-trans-retinal
11.54Single6RZ4Pranlukast6RZ4-CysLT1-Pranlukast-Na
11.54Single6RZ5Zafirlukast6RZ5-CysLT1-Zafirlukast-Na
11.54Single7EUOfMLF7EUO-FPR1-ALX-fMLF-Gi1/&β;1/&γ;2
11.54Single7M3JNPS-2143; PO47M3J-CaS-NPS-2143; PO4
11.54Single7TRKIperoxo7TRK-M4-Iperoxo-Gi1/&β;1/&γ;2
11.54Single7VV0PAMP-127VV0-MRGPRX2-PAMP-12
11.54Single7WC6LSD7WC6-5-HT2A-LSD
11.54Single8E9ZIperoxo8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
11.54Single8EA0Iperoxo8EA0-M3-Iperoxo
11.54Single8IZ4Lysophosphatidylserine8IZ4-GPR34-Lysophosphatidylserine-Gi1/&β;1/&γ;2
11.54Consensus5ht1_onOrthosteric Ligand5ht1a_on 5ht1d_on 5ht1e_on 5ht1f_on 5ht1b_on
11.54Consensusalpha2a_onOrthosteric Ligand7EJ0-α2a-L-Norepinephrine-Go/&β;1/&γ;2 7EJK-α2a-Oxymetazoline-Go/&β;1/&γ;2 7W7E-α2a-W58-Go/&β;1/&γ;2 7W6P-α2a-W96-Go/&β;1/&γ;2 7EJ8-α2a-Brimonidine-Go/&β;1/&γ;2 7EJA-α2a-Dexmedetomidine-Go/&β;1/&γ;2
11.54Consensusgo_amineOrthosteric Ligandgo_adrenergic go_muscarinic go_5ht
11.54Consensusgq_muscarinicOrthosteric Ligand6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/&β;1/&γ;2
11.54Consensusgs_muscarinicOrthosteric Ligand8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
11.54Consensusm1_onOrthosteric Ligand6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/&β;1/&γ;2
11.54Consensusm2_offOrthosteric Ligand5ZKB-M2-AF-DX 384 5ZKC-M2-N-Methyl Scopolamine 5ZK3-M2-Quinuclidinyl benzilate hydrobromide
11.54Consensusm3_onOrthosteric Ligand8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
11.11Single4U15Tiotropium4U15-M3-Tiotropium
11.11Single5V54Methiothepin5V54-5-HT1B-Methiothepin
11.11Single5ZHPPubChem 1348285895ZHP-M3-PubChem 134828589
11.11Single5ZKBAF-DX 3845ZKB-M2-AF-DX 384
11.11Single6E59L-7607356E59-NK1-L-760735
11.11Single6O3CCholesterol6O3C-SMO-SAG21k-Cholesterol
11.11Single6OIJIperoxo6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/&β;1/&γ;2
11.11Single6OL9Tiotropium6OL9-M5-Tiotropium
11.11Single6W2XPubChem 237279706W2X-GABAB1, GABAB2-PubChem 5311042-PubChem 23727970
11.11Single6Z4QSR142948A6Z4Q-NTS1-SR142948A
11.11Single7TRQIperoxo7TRQ-M4-Iperoxo-VU0467154-Gi1/&β;1/&γ;2
11.11Single7WVXHumanin7WVX-FPR2-ALX-Humanin-Gi2/&β;1/&γ;2
11.11Single8IUKPGF2-alpha8IUK-FP-alpha-PGF2-alpha-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
11.11Single8JD0J9R8JD0-mGlu2; mGlu3-Glutamate-J9R
11.11Single8JXXClobenpropit8JXX-H4-Clobenpropit-Gi1/&β;1/&γ;2
11.11Single8X79MRE-2698X79-I2-MRE-269-Gs/&β;1/&γ;2
11.11Consensus5ht1_offOrthosteric Ligand5ht1b_off
11.11Consensus5ht1b_offOrthosteric Ligand5V54-5-HT1B-Methiothepin
11.11Consensusgo_adrenergicOrthosteric Ligand7EJ0-α2a-L-Norepinephrine-Go/&β;1/&γ;2 7EJK-α2a-Oxymetazoline-Go/&β;1/&γ;2 7W7E-α2a-W58-Go/&β;1/&γ;2 7W6P-α2a-W96-Go/&β;1/&γ;2 6K41-α2b-Dexmedetomidine-Go/&β;1/&γ;2 7EJ8-α2a-Brimonidine-Go/&β;1/&γ;2 7EJA-α2a-Dexmedetomidine-Go/&β;1/&γ;2
11.11Consensusgs_ctOrthosteric Ligand7TYN-CT-Calcitonin-1-Gs/&β;1/&γ;2 6NIY-CT-Adrenomedullin-Gs/&β;1/&γ;2 8F0J-CT-Pramlintide analogue san45-Gs/&β;1/&γ;2 7TYL-CT-Amylin-Gs/&β;1/&γ;2 8F0K-CT (AMY3)-Pramlintide analogue san385-Gs/&β;1/&γ;2; RAMP3
11.11Consensush1_offOrthosteric Ligand3RZE-H1-Cidoxepin 8X5Y-H1-Astemizole 8X63-H1-Mepyramine 8X64-H1-Desloratadine
11.11Consensushistamine_offOrthosteric Ligandh1_off
11.11Consensusm3_offOrthosteric Ligand4U15-M3-Tiotropium 4U16-M3-N-Methyl Scopolamine 5ZHP-M3-PubChem 134828589
11.11Consensusm5_offOrthosteric Ligand6OL9-M5-Tiotropium
11.11Consensusmuscarinic_offOrthosteric Ligandm2_off m3_off m4_off m5_off m1_off
11.11Consensusnk1_offOrthosteric Ligand6J20-NK1-Aprepitant 6HLL-NK1-CP99994 6E59-NK1-L-760735
11.11Consensusnpy1_offOrthosteric Ligand5ZBH-Y1-BMS-193885 5ZBQ-Y1-UR-MK-299
10.81Single7TYWCalcitonin-17TYW-CT (AMY1)-Calcitonin-1-Gs/&β;1/&γ;2; RAMP1
10.81Consensuscalcitonin_onOrthosteric Ligandct_on ctlike_on
10.71Single4N4WSANT-14N4W-SMO-SANT-1
10.71Single4OR2FITM4OR2-mGlu1; mGlu1-FITM
10.71Single5CXVTiotropium5CXV-M1-Tiotropium
10.71Single6HLPNetupitant6HLP-NK1-Netupitant
10.71Single6W2YPubChem 237279706W2Y-GABAB1; GABAB1-PubChem 5311042-PubChem 23727970
10.71Single6XBLCholesterol6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
10.71Single7XW6ML1097XW6-TSH-M22 Fab-ML109-Gs/&β;1/&γ;2
10.71Single8DWCProenkephalin-A8DWC-MRGPRX1-Proenkephalin-A-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
10.71Single8E9W2-Deoxycytidine8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
10.71Consensusgi_class-fOther Ligandgi_frizzled
10.71Consensusgi_frizzledOther Ligand6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
10.71Consensusm1_offOrthosteric Ligand5CXV-M1-Tiotropium
10.71Consensusnts1_offOrthosteric Ligand6Z4Q-NTS1-SR142948A 6Z4S-NTS1-SR48692
10.71Consensusnts_offOrthosteric Ligandnts1_off
10.53Single5MZPCaffeine5MZP-A2A-Caffeine-Na
10.53Single6W25Ca6W25-MC4-SHU9119-Ca
10.53Single7TYIAmylin7TYI-CT-Amylin-Gs/&β;1/&γ;2
10.53Single7TYLAmylin7TYL-CT-Amylin-Gs/&β;1/&γ;2
10.53Single7TYNCalcitonin-17TYN-CT-Calcitonin-1-Gs/&β;1/&γ;2
10.53Single8WCBCyclohexylammonium ion8WCB-TA1-Cyclohexylammonium ion-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
10.34Single4OR2FITM4OR2-mGlu1; mGlu1-FITM
10.34Single7QVMOxytocin7QVM-OT-Oxytocin-chim(NtGi1-Go-CtGq)/&β;1/&γ;2
10.34Single8E9YPubChem 4466038E9Y-M3-PubChem 446603-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
10.26Single7TYHCalcitonin-17TYH-CT (AMY2)-Calcitonin-1-Gs/&β;1/&γ;2; RAMP2
10.00Single6RZ6ONO-25703666RZ6-CysLT2-ONO-2570366
10.00Single6XBJCholesterol6XBJ-SMO-Cholesterol-Gi1/&β;1/&γ;2
10.00Single8HQMNPGLY8HQM-GPR132-NPGLY-Gi1/&β;1/&γ;2
10.00Single8SAI1-oleoyl-2-hydroxy-sn-glycero-3-phospho-L-serine8SAI-GPR34-1-oleoyl-2-hydroxy-sn-glycero-3-phospho-L-serine-Gi1/&β;1/&γ;2
10.00Single8SZICa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZI-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi3/&β;1/&γ;2
9.76Single9AUCCalcitonin gene-related peptide-19AUC-CT-Calcitonin gene-related peptide-1-Gs/&β;1/&γ;2; RAMP1
9.68Single6RZ8ONO-20803656RZ8-CysLT2-ONO-2080365
9.52Single2HPYAll-trans-retinal2HPY-Rhodopsin-All-trans-retinal
9.52Single6XBM25(S)-Epoxycholesterol6XBM-SMO-25(S)-Epoxycholesterol-Gi1/&β;1/&γ;2
9.52Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
9.52Single7MTBAll-trans-retinal7MTB-Rhodopsin-All-trans-retinal-GRK1
9.52Single8HVINOX-6-78HVI-GPR132-NOX-6-7-Gi1/&β;1/&γ;2
9.52Single8IWM2-Phenylethylamine8IWM-TAAR9-2-Phenylethylamine
9.52Single8WC5Tetramethylammonium ion8WC5-TA1-Tetramethylammonium ion-chim(NtGi1-Gs)/&β;1/&γ;2
9.52Consensussensory_onOrthosteric Ligandopsin_on
9.38Single8DWGProenkephalin-A8DWG-MRGPRX1-Proenkephalin-A-ML382-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
9.30Single8F2APramlintide analogue san3858F2A-CT (AMY3)-Pramlintide analogue san385-Gs/&β;1/&γ;2; RAMP3
9.09Single3C9M11-cis-Retinal3C9M-Rhodopsin-11-cis-Retinal
9.09Single3UZAGTPL92363UZA-A2A-GTPL9236
9.09Single6D32Cyclopamine6D32-SMO-Cyclopamine-Cyclopamine
9.09Single7D77Hydrocortisone7D77-ADGRG3-Hydrocortisone-Go/&β;1/&γ;2
9.09Single7MT8All-trans-retinal7MT8-Rhodopsin-All-trans-retinal-GRK1
9.09Single7MT9All-trans-retinal7MT9-Rhodopsin-All-trans-retinal-GRK1
9.09Single7MTAAll-trans-retinal7MTA-Rhodopsin-All-trans-retinal-GRK1
9.09Single7V6APubChem 98642757V6A-M4-PubChem 9864275-Gi1/&β;1/&γ;2
9.09Single8DPILorcaserin8DPI-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
9.09Single8EITDoconexent8EIT-FFA1 (GPR40)-Doconexent-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
9.09Single8IU2Retinal8IU2-Opsin1LW-Retinal-Gi1/&β;1/&γ;2
9.09Single8IW72-Phenylethylamine8IW7-TAAR9-2-Phenylethylamine-chim(NtGi1-Gs)/&β;1/&γ;2
9.09Single8J21Butyric acid8J21-FFA3-Butyric acid-Gi1/&β;1/&γ;2
9.09Single8POKHistamine8POK-H2-Histamine-Gs/&β;1/&γ;2
9.09Consensusadgrg3_onOrthosteric Ligand7D77-ADGRG3-Hydrocortisone-Go/&β;1/&γ;2 7D76-ADGRG3-Beclomethasone-Go/&β;1/&γ;2
9.09Consensusffa3_onOrthosteric Ligand8J21-FFA3-Butyric acid-Gi1/&β;1/&γ;2
9.09Consensusopsin_onOrthosteric Ligand6OYA-Rhodopsin-All-trans-retinal-Gt/&β;1/&γ;1
8.89Single7TYOCalcitonin7TYO-CT-Calcitonin-Gs/&β;1/&γ;2
8.82Single6WIVPubChem 52923113; PubChem 529246456WIV-GABAB1, GABAB2-PubChem 52923113; PubChem 52924645
8.70Single1L9H11-cis-Retinal1L9H-Rhodopsin-11-cis-Retinal
8.70Single1U1911-cis-Retinal1U19-Rhodopsin-11-cis-Retinal
8.70Single2G87All-trans-retinal2G87-Rhodopsin-All-trans-retinal
8.70Single2I3511-cis-Retinal2I35-Rhodopsin-11-cis-Retinal
8.70Single3AYMAll-trans-retinal3AYM-Rhodopsin-All-trans-retinal
8.70Single4O9RCyclopamine4O9R-SMO-Cyclopamine
8.70Single5L7IVismodegib5L7I-SMO-Vismodegib
8.70Single6I9K9-cis-Retinal6I9K-Rhodopsin-9-cis-Retinal
8.70Single6QNOAll-trans-retinal6QNO-Rhodopsin-All-trans-retinal-Gi1/&β;1/&γ;1
8.70Single6TP4ACT-4622066TP4-OX1-ACT-462206
8.70Single7D76Beclomethasone7D76-ADGRG3-Beclomethasone-Go/&β;1/&γ;2
8.70Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
8.70Single7DFLHistamine7DFL-H1-Histamine-chim(NtGi1L-Gq)/&β;1/&γ;2
8.70Single7V68Iperoxo7V68-M4-Iperoxo-PubChem 57664406-Gi1/&β;1/&γ;2
8.70Single7VDHC48/807VDH-MRGPRX2-C48/80-Gi1/&β;1/&γ;2
8.70Single7XTBSerotonin7XTB-5-HT6-Serotonin-Gs/&β;1/&γ;2
8.70Single8W8BSEP-3638568W8B-5-HT1A-SEP-363856-Gi1/&β;1/&γ;2
8.70Single8X2K5YM8X2K-GPR3-5YM-chim(NtGi1-Gs)/&β;1/&γ;2
8.70Consensusgo_adhesionOrthosteric Ligand7D77-ADGRG3-Hydrocortisone-Go/&β;1/&γ;2 7D76-ADGRG3-Beclomethasone-Go/&β;1/&γ;2
8.70Consensusgo_class-b2Orthosteric Ligandgo_adhesion
8.70Consensusgq_histamineOrthosteric Ligand7DFL-H1-Histamine-chim(NtGi1L-Gq)/&β;1/&γ;2
8.70Consensush1_onOrthosteric Ligand7DFL-H1-Histamine-chim(NtGi1L-Gq)/&β;1/&γ;2
8.33Single1GZM11-cis-Retinal1GZM-Rhodopsin-11-cis-Retinal
8.33Single2PED9-cis-Retinal2PED-Rhodopsin-9-cis-Retinal
8.33Single3C9L11-cis-Retinal3C9L-Rhodopsin-11-cis-Retinal
8.33Single4QINSAG1.54QIN-SMO-SAG1.5
8.33Single6O3CSAG21k6O3C-SMO-SAG21k-Cholesterol
8.33Single6TQ6PubChem 1457142836TQ6-OX1-PubChem 145714283
8.33Single7F24Dopamine7F24-D1-Dopamine-GDP-Gs/&β;1/&γ;2
8.33Single7SRSLSD7SRS-5-HT2B-LSD-Arrestin2
8.33Single7T6SPubChem 247763417T6S-FPR2-ALX-PubChem 24776341-Gi1/&β;1/&γ;2
8.33Single7VV5C48/807VV5-MRGPRX2-C48/80-Gi1/&β;1/&γ;2
8.33Single7X2FDopamine7X2F-D1-Dopamine-Mevidalen-Gs/&β;1/&γ;2
8.33Single8A6CAll-trans-retinal8A6C-Rhodopsin-All-trans-retinal
8.33Single8A6DAll-trans-retinal8A6D-Rhodopsin-All-trans-retinal
8.33Single8A6EAll-trans-retinal8A6E-Rhodopsin-All-trans-retinal
8.33Single8F0JPramlintide analogue san458F0J-CT-Pramlintide analogue san45-Gs/&β;1/&γ;2
8.33Single8J20Valeric acid8J20-FFA3-Valeric acid-AR420626-Gi1/&β;1/&γ;2
8.33Consensus5ht2c_onOrthosteric Ligand8DPF-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8DPG-5-HT2C-Psilocin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
8.33Consensusclass-f_offOrthosteric Ligandsmo_off
8.33Consensusctlike_onOrthosteric Ligand6E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/&β;1/&γ;2; RAMP1 6UUN-CT Like (AM1)-Adrenomedullin-Gs/&β;1/&γ;2; RAMP2
8.33Consensusffa3_on_alloOrthosteric Ligand8J20-FFA3-Valeric acid-AR420626-Gi1/&β;1/&γ;2
8.33Consensusgs_5htOrthosteric Ligand7XT8-5-HT4-Serotonin-Gs/&β;1/&γ;2 7XTB-5-HT6-Serotonin-Gs/&β;1/&γ;2 8JLZ-5-HT6-ST1936-Gs/&β;1/&γ;2 7XTC-5-HT7-5-CT-Gs/&β;1/&γ;2 6WHA-5-HT2A-DB13948-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 7RAN-5-HT2A-PubChem 164575847-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8DPF-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8DPG-5-HT2C-Psilocin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
8.33Consensusopsin_offOrthosteric Ligand1U19-Rhodopsin-11-cis-Retinal 2PED-Rhodopsin-9-cis-Retinal 5TE5-Rhodopsin-20-Methanoretinal
8.33Consensussmo_on_alloOther Ligand6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
8.00Single3OAX11-cis-Retinal3OAX-Rhodopsin-11-cis-Retinal
8.00Single3RZECidoxepin3RZE-H1-Cidoxepin
8.00Single4N6HNaltrindole4N6H-δ-Naltrindole-Na
8.00Single6FK8PubChem 1324730356FK8-Rhodopsin-PubChem 132473035
8.00Single6TPKRetosiban6TPK-OT-Retosiban
8.00Single6XBLSAG6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
8.00Single6ZINSR486926ZIN-NTS1-SR48692
8.00Single7CMVPD1289077CMV-D3-PD128907-Gi1/&β;1/&γ;2
8.00Single7E33BRL-544437E33-5-HT1E-BRL-54443-Gi1/&β;1/&γ;2
8.00Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
8.00Single7VODCariprazine7VOD-5-HT2A-Cariprazine
8.00Single7VV6C48/807VV6-MRGPRX2-C48/80
8.00Single7WVUfMLF7WVU-FPR1-ALX-fMLF-Gi1/&β;1/&γ;2
8.00Single7ZBC11-cis-Retinal7ZBC-Rhodopsin-11-cis-Retinal
8.00Single7ZBE11-cis-Retinal7ZBE-Rhodopsin-11-cis-Retinal
8.00Single7ZI0SAG7ZI0-SMO-SAG-Cholesterol
8.00Single8DPGPsilocin8DPG-5-HT2C-Psilocin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
8.00Single8FCZ11-cis-Retinal8FCZ-Rhodopsin-11-cis-Retinal
8.00Single8H4LDoconexent8H4L-FFA4-Doconexent-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
8.00Single8HQN9(S)-HODE8HQN-GPR132-9(S)-HODE-Gi1/&β;1/&γ;2
8.00Consensus5ht1e_onOrthosteric Ligand7E33-5-HT1E-BRL-54443-Gi1/&β;1/&γ;2
8.00Consensusdop_off_alloOrthosteric Ligand4N6H-δ-Naltrindole-Na
8.00Consensusgi_class-fOrthosteric Ligandgi_frizzled
8.00Consensusgi_frizzledOrthosteric Ligand6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
8.00Consensusot_offOrthosteric Ligand6TPK-OT-Retosiban
8.00Consensusvasopressin-ot_offOrthosteric Ligandot_off
7.69Single1HZX11-cis-Retinal1HZX-Rhodopsin-11-cis-Retinal
7.69Single5DSGTiotropium5DSG-M4-Tiotropium
7.69Single6FK7PubChem 1324730346FK7-Rhodopsin-PubChem 132473034
7.69Single6FKCPubChem 1324730396FKC-Rhodopsin-PubChem 132473039
7.69Single6FKDPubChem 1373491836FKD-Rhodopsin-PubChem 137349183
7.69Single6WHADB139486WHA-5-HT2A-DB13948-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
7.69Single7E9GJNJ-404118137E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/&β;1/&γ;2
7.69Single7PP1Selatogrel7PP1-P2Y12-Selatogrel
7.69Single7TYFAmylin7TYF-CT (AMY1)-Amylin-Gs/&β;1/&γ;2; RAMP1
7.69Single8JGGBAM8-228JGG-MRGPRX1-BAM8-22-Gi1/&β;1/&γ;2
7.69Single8X64Desloratadine8X64-H1-Desloratadine
7.69Consensusm4_offOrthosteric Ligand5DSG-M4-Tiotropium
7.69Consensusp2y12_offOrthosteric Ligand4NTJ-P2Y12-AZD1283 7PP1-P2Y12-Selatogrel
7.69Consensustachykinin_offOrthosteric Ligandnk1_off
7.41Single4NTJAZD12834NTJ-P2Y12-AZD1283
7.41Single5CGCHTL142425CGC-mGlu5-HTL14242
7.41Single5ZBQUR-MK-2995ZBQ-Y1-UR-MK-299
7.41Single6OIKIperoxo6OIK-M2-Iperoxo-LY2119620-chim(NtGi1-Go)/&β;1/&γ;2
7.41Single6Z4SSR486926Z4S-NTS1-SR48692
7.32Single7TZFAmylin7TZF-CT (AMY3)-Amylin-Gs/&β;1/&γ;2; RAMP3
7.32Single8F0KPramlintide analogue san3858F0K-CT (AMY3)-Pramlintide analogue san385-Gs/&β;1/&γ;2; RAMP3
7.14Single5ZBHBMS-1938855ZBH-Y1-BMS-193885
7.14Single7EPENAM5637EPE-mGlu-NAM563
7.14Single7EW4CYM55417EW4-S1P3-CYM5541-Gi1/&β;1/&γ;2
7.14Single7TYYCalcitonin-17TYY-CT (AMY2)-Calcitonin-1-Gs/&β;1/&γ;2; RAMP2
6.90Single6RZ7ONO-25703666RZ7-CysLT2-ONO-2570366
6.90Single8JGFBAM8-228JGF-MRGPRX1-BAM8-22-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
6.67Single5CGDHTL142425CGD-mGlu5-HTL14242
6.67Single6RZ9ONO-27703726RZ9-CysLT2-ONO-2770372
6.67Single8JD3HZR; PEF8JD3-mGlu2; mGlu3-Glutamate-HZR; PEF-Gi1/&β;1/&γ;2
6.67Consensuscyslt2_offOrthosteric Ligand6RZ6-CysLT2-ONO-2570366 6RZ9-CysLT2-ONO-2770372 6RZ8-CysLT2-ONO-2080365
6.67Consensuscyslt_offOrthosteric Ligandcyslt2_off
5.88Single6D32Cyclopamine6D32-SMO-Cyclopamine-Cyclopamine
5.88Single6D35Cholesterol6D35-SMO-Cholesterol
5.88Single6N51Quisqualate6N51-mGlu5; mGlu5-Quisqualate
5.88Single6N51Quisqualate6N51-mGlu5; mGlu5-Quisqualate
5.88Single6UO8SKF975416UO8-GABAB1, GABAB2-SKF97541-GS39783
5.88Single6UO9SKF975416UO9-GABAB1, GABAB2-SKF97541
5.88Single6W2XPubChem 53110426W2X-GABAB1, GABAB2-PubChem 5311042-PubChem 23727970
5.88Single6W2YPubChem 53110426W2Y-GABAB1; GABAB1-PubChem 5311042-PubChem 23727970
5.88Single6W2YPubChem 53110426W2Y-GABAB1; GABAB1-PubChem 5311042-PubChem 23727970
5.88Single7C7QBaclofen7C7Q-GABAB1, GABAB2-Baclofen-PubChem 7023848
5.88Single7C7SCGP546267C7S-GABAB1, GABAB2-CGP54626
5.88Single7CUMCGP546267CUM-GABAB1, GABAB2-CGP54626-Phospholipid
5.88Single7DD5Ca37DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
5.88Single7DD5Ca7DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
5.88Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
5.88Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
5.88Single7DGEQuisqualate7DGE-mGlu1; mGlu1-Quisqualate
5.88Single7DTTCa7DTT-CaS-Ca-Ca
5.88Single7DTTCa7DTT-CaS-Ca-Ca
5.88Single7DTUTryptophan7DTU-CaS-Tryptophan
5.88Single7DTUTryptophan7DTU-CaS-Tryptophan
5.88Single7DTVCa7DTV-CaS-Ca-Ca; Tryptophan
5.88Single7DTVCa; Tryptophan7DTV-CaS-Ca-Ca; Tryptophan
5.88Single7DTVCa7DTV-CaS-Ca-Ca; Tryptophan
5.88Single7DTVCa; Tryptophan7DTV-CaS-Ca-Ca; Tryptophan
5.88Single7E6TCa7E6T-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
5.88Single7E6TCa; Ca; Cyclomethyltryptophan; PO47E6T-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
5.88Single7E6TCa7E6T-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
5.88Single7E6TCa; Ca; Cyclomethyltryptophan; PO47E6T-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
5.88Single7E9GEglumetad7E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/&β;1/&γ;2
5.88Single7E9GEglumetad7E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/&β;1/&γ;2
5.88Single7E9HPhosphoserine7E9H-mGlu4; mGlu4-Phosphoserine-Gi3/&β;1/&γ;2
5.88Single7E9HPhosphoserine7E9H-mGlu4; mGlu4-Phosphoserine-Gi3/&β;1/&γ;2
5.88Single7EB2Baclofen7EB2-GABAB1, GABAB2-Baclofen-rac-BHFF-Gi1/&β;1/&γ;2
5.88Single7EPBEglumetad7EPB-mGlu2; mGlu2-Eglumetad
5.88Single7EPBEglumetad7EPB-mGlu2; mGlu2-Eglumetad
5.88Single7FD8Quisqualate7FD8-mGlu5; mGlu5-Quisqualate
5.88Single7FD8Quisqualate7FD8-mGlu5; mGlu5-Quisqualate
5.88Single7FD9LY3414957FD9-mGlu5; mGlu5-LY341495
5.88Single7FD9LY3414957FD9-mGlu5; mGlu5-LY341495
5.88Single7FIHhCG7FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/&β;1/&γ;2
5.88Single7FIIhCG7FII-LH-hCG-6fuf
5.88Single7M3ECa; Ca; Tryptophan; NPS-2143; PO47M3E-CaS-Ca; Ca; Tryptophan; NPS-2143; PO4
5.88Single7M3ECa; Ca; Tryptophan; NPS-2143; PO47M3E-CaS-Ca; Ca; Tryptophan; NPS-2143; PO4
5.88Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
5.88Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
5.88Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
5.88Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
5.88Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
5.88Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
5.88Single7MTQLY3414957MTQ-mGlu2; mGlu2-LY341495
5.88Single7MTQLY3414957MTQ-mGlu2; mGlu2-LY341495
5.88Single7MTRGlutamate7MTR-mGlu2; mGlu2-Glutamate-ADX55164
5.88Single7MTRGlutamate7MTR-mGlu2; mGlu2-Glutamate-ADX55164
5.88Single7MTSGlutamate7MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/&β;1/&γ;2
5.88Single7MTSGlutamate7MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/&β;1/&γ;2
5.88Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
5.88Single7SILCa7SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
5.88Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
5.88Single7SILCa7SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
5.88Single7SIMCa7SIM-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
5.88Single7SIMCa; Ca; Cyclomethyltryptophan; PO47SIM-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
5.88Single7SIMCa7SIM-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
5.88Single7SIMCa; Ca; Cyclomethyltryptophan; PO47SIM-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
5.88Single7T9NM22 Fab7T9N-TSH-M22 Fab-PubChem 644078-Gs/&β;1/&γ;2
5.88Single7WI6LY3414957WI6-mGlu3; mGlu3-LY341495
5.88Single7WI6LY3414957WI6-mGlu3; mGlu3-LY341495
5.88Single7WI8LY3414957WI8-mGlu3; mGlu3-LY341495
5.88Single7WI8LY3414957WI8-mGlu3; mGlu3-LY341495
5.88Single7WIHLY27941937WIH-mGlu3; mGlu3-LY2794193
5.88Single7WIHLY27941937WIH-mGlu3; mGlu3-LY2794193
5.88Single7XW6M22 Fab7XW6-TSH-M22 Fab-ML109-Gs/&β;1/&γ;2
5.88Single7XW7K1-707XW7-TSH-K1-70
5.88Single8JCULY3414958JCU-mGlu2; mGlu3-LY341495
5.88Single8JCULY3414958JCU-mGlu2; mGlu3-LY341495
5.88Single8JCVLY3414958JCV-mGlu2; mGlu3-LY341495
5.88Single8JCVLY3414958JCV-mGlu2; mGlu3-LY341495
5.88Single8JCWLY3414958JCW-mGlu2; mGlu3-LY341495
5.88Single8JCWLY3414958JCW-mGlu2; mGlu3-LY341495
5.88Single8JCXLY3414958JCX-mGlu2; mGlu3-LY341495
5.88Single8JCXLY3414958JCX-mGlu2; mGlu3-LY341495
5.88Single8JCYLY3414958JCY-mGlu2; mGlu3-LY341495
5.88Single8JCYLY3414958JCY-mGlu2; mGlu3-LY341495
5.88Single8JCZLY3414958JCZ-mGlu2; mGlu3-LY341495
5.88Single8JCZLY3414958JCZ-mGlu2; mGlu3-LY341495
5.88Single8JD0Glutamate8JD0-mGlu2; mGlu3-Glutamate-J9R
5.88Single8JD1Glutamate8JD1-mGlu2; mGlu3-Glutamate
5.88Single8JD1Glutamate8JD1-mGlu2; mGlu3-Glutamate
5.88Single8JD2Glutamate8JD2-mGlu2; mGlu3-Glutamate
5.88Single8JD2Glutamate8JD2-mGlu2; mGlu3-Glutamate
5.88Single8JD3Glutamate8JD3-mGlu2; mGlu3-Glutamate-HZR; PEF-Gi1/&β;1/&γ;2
5.88Single8JD3Glutamate8JD3-mGlu2; mGlu3-Glutamate-HZR; PEF-Gi1/&β;1/&γ;2
5.88Single8JD4Glutamate8JD4-mGlu2; mGlu4-Glutamate
5.88Single8JD4Glutamate8JD4-mGlu2; mGlu4-Glutamate
5.88Single8JD5Glutamate8JD5-mGlu2; mGlu4-Glutamate-BQI; HZE; PEF-Gi1/&β;1/&γ;2
5.88Single8JD5Glutamate8JD5-mGlu2; mGlu4-Glutamate-BQI; HZE; PEF-Gi1/&β;1/&γ;2
5.88Single8JD6Phosphoserine8JD6-mGlu4; mGlu4-Phosphoserine-N-(3-chlorophenyl)pyridine-2-carboxamide-Gi3/&β;1/&γ;2
5.88Single8JD6Phosphoserine8JD6-mGlu4; mGlu4-Phosphoserine-N-(3-chlorophenyl)pyridine-2-carboxamide-Gi3/&β;1/&γ;2
5.88Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
5.88Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
5.88Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
5.88Single8SZGCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-chim(NtGi1-Gq)/&β;1/&γ;2
5.88Single8SZGCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-chim(NtGi1-Gq)/&β;1/&γ;2
5.88Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/&β;1/&γ;2
5.88Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/&β;1/&γ;2
5.88Single8SZICa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZI-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi3/&β;1/&γ;2
5.88Single8SZICa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZI-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi3/&β;1/&γ;2
5.88Single8T7HQuisqualate8T7H-mGlu5; mGlu5-Quisqualate
5.88Single8T7HQuisqualate8T7H-mGlu5; mGlu5-Quisqualate
5.88Single8T8MQuisqualate8T8M-mGlu5; mGlu5-Quisqualate
5.88Single8T8MQuisqualate8T8M-mGlu5; mGlu5-Quisqualate
5.88Single8TAOQuisqualate8TAO-mGlu5; mGlu5-Quisqualate-CDPPB
5.88Single8TAOQuisqualate8TAO-mGlu5; mGlu5-Quisqualate-CDPPB
5.88Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
5.88Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
5.88Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
5.88Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
5.88Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
5.88Single9AXFCa9AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
5.88Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
5.88Single9AXFCa9AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
5.88Single9AYFCa9AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/&β;1/&γ;2
5.88Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/&β;1/&γ;2
5.88Consensusclass-c_offOrthosteric Ligandgabab_off mglu_off
5.88Consensusclass-c_offOrthosteric Ligandgabab_off mglu_off
5.88Consensusclass-c_onOrthosteric Ligandgabab_on mglu_on
5.88Consensusclass-c_onOrthosteric Ligandgabab_on mglu_on
5.88Consensusfsh_on_alloOrthosteric Ligand8I2G-FSH-Glycoprotein hormones alpha chain-Compound 716340-Gs/&β;1/&γ;2
5.88Consensusgabab_offOrthosteric Ligand7C7S-GABAB1, GABAB2-CGP54626 7CUM-GABAB1, GABAB2-CGP54626-Phospholipid 6W2X-GABAB1, GABAB2-PubChem 5311042-PubChem 23727970
5.88Consensusgabab_onOrthosteric Ligand7EB2-GABAB1, GABAB2-Baclofen-rac-BHFF-Gi1/&β;1/&γ;2
5.88Consensusgi_class-cOrthosteric Ligandgi_mglu gi_gaba
5.88Consensusgi_class-cOrthosteric Ligandgi_mglu gi_gaba
5.88Consensusgi_gabaOrthosteric Ligand7EB2-GABAB1, GABAB2-Baclofen-rac-BHFF-Gi1/&β;1/&γ;2
5.88Consensusgi_mgluOrthosteric Ligand7E9H-mGlu4; mGlu4-Phosphoserine-Gi3/&β;1/&γ;2 8JD6-mGlu4; mGlu4-Phosphoserine-N-(3-chlorophenyl)pyridine-2-carboxamide-Gi3/&β;1/&γ;2
5.88Consensusgi_mgluOrthosteric Ligand7E9H-mGlu4; mGlu4-Phosphoserine-Gi3/&β;1/&γ;2 8JD6-mGlu4; mGlu4-Phosphoserine-N-(3-chlorophenyl)pyridine-2-carboxamide-Gi3/&β;1/&γ;2
5.88Consensusgphr_onOrthosteric Ligandlh_on tsh_on
5.88Consensusgs_gphrOrthosteric Ligand7T9I-TSH-TSH-Gs/&β;1/&γ;2 7FIG-LH-hCG-chim(NtGi1L-Gs)/&β;1/&γ;2
5.88Consensusgs_proteinOrthosteric Ligandgs_gphr
5.88Consensuslh_onOrthosteric Ligand7FIG-LH-hCG-chim(NtGi1L-Gs)/&β;1/&γ;2
5.88Consensuslh_on_alloOrthosteric Ligand7FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/&β;1/&γ;2
5.88Consensusmglu2_offOrthosteric Ligand7MTQ-mGlu2; mGlu2-LY341495
5.88Consensusmglu2_offOrthosteric Ligand7MTQ-mGlu2; mGlu2-LY341495
5.88Consensusmglu2_onOrthosteric Ligand7MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/&β;1/&γ;2 7E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/&β;1/&γ;2
5.88Consensusmglu2_onOrthosteric Ligand7MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/&β;1/&γ;2 7E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/&β;1/&γ;2
5.88Consensusmglu3_offOrthosteric Ligand7WI8-mGlu3; mGlu3-LY341495 7WIH-mGlu3; mGlu3-LY2794193
5.88Consensusmglu3_offOrthosteric Ligand7WI8-mGlu3; mGlu3-LY341495 7WIH-mGlu3; mGlu3-LY2794193
5.88Consensusmglu4_onOrthosteric Ligand7E9H-mGlu4; mGlu4-Phosphoserine-Gi3/&β;1/&γ;2 8JD6-mGlu4; mGlu4-Phosphoserine-N-(3-chlorophenyl)pyridine-2-carboxamide-Gi3/&β;1/&γ;2
5.88Consensusmglu4_onOrthosteric Ligand7E9H-mGlu4; mGlu4-Phosphoserine-Gi3/&β;1/&γ;2 8JD6-mGlu4; mGlu4-Phosphoserine-N-(3-chlorophenyl)pyridine-2-carboxamide-Gi3/&β;1/&γ;2
5.88Consensusmglu5_offOrthosteric Ligand7FD9-mGlu5; mGlu5-LY341495
5.88Consensusmglu5_offOrthosteric Ligand7FD9-mGlu5; mGlu5-LY341495
5.88Consensusmglu_offOrthosteric Ligandmglu2_off mglu3_off mglu5_off
5.88Consensusmglu_offOrthosteric Ligandmglu2_off mglu3_off mglu5_off
5.88Consensusmglu_onOrthosteric Ligandmglu2_on mglu4_on
5.88Consensusmglu_onOrthosteric Ligandmglu2_on mglu4_on
5.88Consensussmo_off_alloOther Ligand6D32-SMO-Cyclopamine-Cyclopamine
5.88Consensustsh_onOrthosteric Ligand7T9I-TSH-TSH-Gs/&β;1/&γ;2
5.88Consensustsh_on_alloOrthosteric Ligand7XW5-TSH-TSH-ML109-Gs/&β;1/&γ;2
5.56Single7DD6Ca7DD6-CaS-Ca-Ca; Ca; Tryptophan
5.56Single7DD6Ca; Ca; Tryptophan7DD6-CaS-Ca-Ca; Ca; Tryptophan
5.56Single7DD6Ca7DD6-CaS-Ca-Ca; Ca; Tryptophan
5.56Single7DD6Ca; Ca; Tryptophan7DD6-CaS-Ca-Ca; Ca; Tryptophan
5.56Single7DD7Ca7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
5.56Single7DD7Ca7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
5.56Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
5.56Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
5.56Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/&β;1/&γ;2
5.56Single9AYFCa9AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/&β;1/&γ;2
5.26Single7KNUCalcitonin gene-related peptide-17KNU-CT Like-Calcitonin gene-related peptide-1-RAMP1
5.26Single7T9MCS-17 Antibody7T9M-TSH-CS-17 Antibody
5.26Single8HS2Fab0468HS2-GPR20-Fab046
5.00Single6O3CCholesterol6O3C-SMO-SAG21k-Cholesterol
5.00Single7FIGhCG7FIG-LH-hCG-chim(NtGi1L-Gs)/&β;1/&γ;2
5.00Single7TYXAmylin7TYX-CT (AMY2)-Amylin-Gs/&β;1/&γ;2; RAMP2
5.00Single7UTZTR14027UTZ-TSH-TR1402-PubChem 644078-Gs/&β;1/&γ;2
5.00Single7XW5TSH7XW5-TSH-TSH-ML109-Gs/&β;1/&γ;2
5.00Single7ZI0Cholesterol7ZI0-SMO-SAG-Cholesterol
5.00Single8TLMAnti-murine CCR8 antibody8TLM-CCR8-Anti-murine CCR8 antibody
5.00Consensusccr8_offOrthosteric Ligand8TLM-CCR8-Anti-murine CCR8 antibody
4.76Single3PXOAll-trans-retinal3PXO-Rhodopsin-All-trans-retinal
4.76Single5DYSAll-trans-retinal5DYS-Rhodopsin-All-trans-retinal
4.76Single5L7DCholesterol5L7D-SMO-Cholesterol
4.76Single7T9ITSH7T9I-TSH-TSH-Gs/&β;1/&γ;2
4.76Single8HSCFab0468HSC-GPR20-Fab046-Gi1/&β;1/&γ;2
4.76Single8I2GGlycoprotein hormones alpha chain8I2G-FSH-Glycoprotein hormones alpha chain-Compound 716340-Gs/&β;1/&γ;2
4.76Consensusgabab_offOther Ligand7C7S-GABAB1, GABAB2-CGP54626 7CUM-GABAB1, GABAB2-CGP54626-Phospholipid 6W2X-GABAB1, GABAB2-PubChem 5311042-PubChem 23727970
4.55Single7VDMSubstance P7VDM-MRGPRX2-Substance P-Gi1/&β;1/&γ;2
4.35Single2ZIY11-cis-Retinal2ZIY-Rhodopsin-11-cis-Retinal
4.35Single3PQRAll-trans-retinal3PQR-Rhodopsin-All-trans-retinal-Gt(CT)
4.35Single6FK9PubChem 1324730366FK9-Rhodopsin-PubChem 132473036
4.35Single7S8O(R)-Zinc-35737S8O-MRGPRX2-(R)-Zinc-3573-Gi1/&β;1/&γ;2
4.35Single8JGBConorfamide-Tx28JGB-MRGPRX1-Conorfamide-Tx2-Gi1/&β;1/&γ;2
4.17Single6FK6PubChem 1324730336FK6-Rhodopsin-PubChem 132473033
4.17Single6PGSGeraniol6PGS-Rhodopsin-Geraniol-Gt(CT)
4.17Single6PH7Nerol6PH7-Rhodopsin-Nerol-Gt(CT)
4.17Single7E2YSerotonin7E2Y-5-HT1A-Serotonin-Gi1/&β;1/&γ;2
4.17Single7S8N(R)-Zinc-35737S8N-MRGPRX2-(R)-Zinc-3573-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
4.17Single7UL2SR486927UL2-NTS1-SR48692-Na
4.17Single8F2BPramlintide analogue san458F2B-CT (AMY3)-Pramlintide analogue san45-Gs/&β;1/&γ;2; RAMP3
4.17Consensusnts1_off_alloOrthosteric Ligand7UL2-NTS1-SR48692-Na
4.00Single6FKBPubChem 1324730386FKB-Rhodopsin-PubChem 132473038
4.00Single7LJDDopamine7LJD-D1-Dopamine-Mevidalen-Gs/&β;1/&γ;1
4.00Single8U8FPML8U8F-GPR3-PML-Gs/&β;1/&γ;2
3.85Single6FKAPubChem 1324730376FKA-Rhodopsin-PubChem 132473037
3.85Single6PELCitronellol6PEL-Rhodopsin-Citronellol-Gt(CT)
3.85Single7EJ8Brimonidine7EJ8-α2a-Brimonidine-Go/&β;1/&γ;2
3.85Single7EJADexmedetomidine7EJA-α2a-Dexmedetomidine-Go/&β;1/&γ;2
3.85Single7VVOPTH7VVO-PTH1-PTH-Gs/&β;1/&γ;2
3.85Single8HJ5PubChem 1390305318HJ5-MRGPRX1-PubChem 139030531-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
3.85Single8IYXYL-3658IYX-GPR34-YL-365
3.85Single8WC8ZH86518WC8-TA1-ZH8651-chim(NtGi1-Gs)/&β;1/&γ;2
3.57Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
3.57Single8SZICa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZI-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi3/&β;1/&γ;2
3.45Single4OO9Mavoglurant4OO9-mGlu5-Mavoglurant
3.45Single7P2L4YI7P2L-mGlu5-4YI
3.45Single8JD5BQI; HZE; PEF8JD5-mGlu2; mGlu4-Glutamate-BQI; HZE; PEF-Gi1/&β;1/&γ;2
3.45Single8JD5BQI; HZE; PEF8JD5-mGlu2; mGlu4-Glutamate-BQI; HZE; PEF-Gi1/&β;1/&γ;2
3.45Consensusmglu2_onOther Ligand7MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/&β;1/&γ;2 7E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/&β;1/&γ;2
3.33Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/&β;1/&γ;2
2.94Single7SHEPI; PE7SHE-GPR158-PI; PE

PDB Summary
PDB 4XT1
Class A
SubFamily Other
Type Unclassified
SubType US28
Species Human cytomegalovirus (strain AD169)
Ligand Fractalkine
Other Ligand(s) -
Protein Partners -
PDB Resolution 2.89
Date 2015-03-04
D.O.I. 10.1126/science.aaa5026
Net Summary
Imin 2.82
Number of Linked Nodes 343
Number of Links 402
Number of Hubs 51
Number of Links mediated by Hubs 192
Number of Communities 12
Number of Nodes involved in Communities 83
Number of Links involved in Communities 111
Path Summary
Number Of Nodes in MetaPath 70
Number Of Links MetaPath 69
Number of Shortest Paths 155217
Length Of Smallest Path 3
Average Path Length 20.5021
Length of Longest Path 42
Minimum Path Strength 1.38
Average Path Strength 6.22539
Maximum Path Strength 17.84
Minimum Path Correlation 0.7
Average Path Correlation 0.939854
Maximum Path Correlation 0.99
Minimum % Of Corr. Nodes 2.7027
Average % Of Corr. Nodes 45.473
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 42.3561
Maximum Path Hubs % 100
AnnotationTypeLinks
Gene OntologyMolecular Function
Gene OntologyBiological Process
Gene OntologyCellular Component
SCOP2Domain Identifier
SCOP2Family Identifier
Membrane Protein Annotations-• Orientations of Proteins in Membranes database (OPM)   • Protein Data Bank of Transmembrane Proteins (PDBTM)   • MemProtMD


Details about the values in these tables can be found in the corresponding documentation page .
CodePCA
PDB ResiduesL:L:?25
Environment DetailsOpen EMBL-EBI Page
CodePCA
NamePidolic acid
Synonyms5-L-oxoproline
Identifier(2S)-5-oxopyrrolidine-2-carboxylic acid
FormulaC5 H7 N O3
Molecular Weight129.114
SMILESC1CC(=O)N[C@@H]1C(=O)O
PubChem7405
Formal Charge0
Total Atoms16
Total Chiral Atoms1
Total Bonds16
Total Aromatic Bonds0

PDBsumOpen PDBsum Page
ChainR
ProteinReceptor
UniProtP69333
Sequence
>4XT1_Chain_R
DYDEDATPC VFTDVLNQS KPVTLFLYG VVFLFGSIG NFLVIFTIT 
WRRRIQCSG DVYFINLAA ADLLFVCTL PLWMQYLLD SVPCTLLTA 
CFYVAMFAS LCFITEIAL DRYYAIVYM RYRPVKQAC LFSIFWWIF 
AVIIAIPHF MVVTKKDNQ CMTDYDYLE VSYPIILNV ELMLGAFVI 
PLSVISYCY YRISRIVAV SQSRHKGRI VRVLIAVVL VFIIFWLPY 
HLTLFVDTL KLLKWISSS CEFERSLKR ALILTESLA FCHCCLNPL 
LYVFVGTKF RQELHCLLA EFR


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  




This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
4XT1AOtherUnclassifiedUS28Human cytomegalovirus (strain ad169)Fractalkine--2.892015-03-0410.1126/science.aaa5026
4XT3AOtherUnclassifiedUS28Human cytomegalovirus (strain ad169)Fractalkine--3.82015-03-0410.1126/science.aaa5026
5WB1AOtherUnclassifiedUS28Human cytomegalovirus (strain towne)---3.512018-06-1310.7554/eLife.35850
5WB2AOtherUnclassifiedUS28Human cytomegalovirus (strain towne)CX3CL1.35--3.52018-06-1310.7554/eLife.35850
7RKFAOtherUnclassifiedUS28Human betaherpesvirus 5FractalkineGDPchim(NtGi1-G11)/&β;1/&γ;242022-01-2610.1126/sciadv.abl5442
7RKMAOtherUnclassifiedUS28Human betaherpesvirus 5Fractalkine-Gi1/&β;1/&γ;23.52022-01-2610.1126/sciadv.abl5442
7RKNAOtherUnclassifiedUS28Human betaherpesvirus 5Fractalkine-Gi1/&β;1/&γ;23.62022-01-2610.1126/sciadv.abl5442




You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download 4XT1.zip



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