Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

All columns can be sorted in ascending/descending alphabetical order, clicking on the corresponding column header.

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg. Int. Strength Num. Of Links Community ConSurf
1NT 11.21114
21x38 6.0475404
31x50 5.26539
42x42 5.526538
52x45 5.5439
62x46 2.8075439
72x50 5.54439
82x64 5.1825416
92x65 5.27415
10E1x50 4.88333618
11E1x52 4.134516
123x22 4.1925412
133x32 2.325416
143x38 4.785407
153x41 5.716515
163x42 4.126538
173x50 6.5575439
183x51 6.576507
19I2x56 5.12333637
204x50 7.6675409
214x52 9.1875414
224x56 10.054515
234x59 4.6675413
24E2 12.11033114
25E2x50 5.0425419
265x39 8.672516
275x461 4.59515
285x58 6.09409
295x62 5.89254106
306x23 5.2954215
316x30 4.55754108
326x44 5.6975409
336x48 5.31408
346x61 4.165414
35E3 5.122513
367x37 4.152516
377x46 4.85439
387x53 6.96539
398x50 9.1975408
40G.HN.11 2.9325222
41G.HN.47 3.1875496
42G.hns1.03 6.305404
43G.S1.02 3.8085195
44G.S2.01 5.665429
45G.S3.04 8.56406
46G.S3.05 4.1175407
47G.S3.08 4.5925429
48G.s3h2.03 4.57429
49G.H2.03 3.77254129
50G.H2.06 4.65129
51G.H2.10 3.6375427
52G.h2s4.01 4.6529
53G.S4.02 3.4625428
54G.S4.04 4.9125139
55G.s4h3.03 7.29408
56G.s4h3.04 7.25833658
57G.H3.02 7.265458
58G.H3.03 5.7575454
59G.H3.13 4.39254265
60G.H3.17 5.77625
61G.H3.18 4.3875429
62G.S5.03 3.335408
63G.S5.04 3.96754139
64G.S5.06 4.835138
65G.s5hg.01 6.2685249
66G.HG.04 5.445459
67G.HG.08 5.075456
68G.HG.15 4.5875457
69G.hgh4.01 5.275456
70G.hgh4.02 5.72286757
71G.hgh4.05 8.338557
72G.H4.03 6.305404
73G.H4.05 8.3275454
74G.H4.10 10.734556
75G.h4s6.02 5.434268
76G.h4s6.12 5.5954214
77G.S6.02 8.4275407
78G.S6.03 7.154135
79G.H5.08 4.585258
80G.H5.20 4.64754109
81G.H5.26 8.795405
82b.ntx3 4.984275
83b.1x3 4.1454278
84b.1x10 4.055158
85b.lhb1x3 3.8675462
86b.lhb1x6 2.96463
87b.lhb1x11 5.0254144
88b.b1x6 7.5225409
89b.l1x3 7.81667699
90b.b2x5 5.756507
91b.b3x3 3.20254118
92b.l3x1 8.2525429
93b.l3x2 4.85667699
94b.b4x3 4.4345117
95b.b4x4 6.528598
96b.b4x5 4.14117
97b.b4x6 8.22833699
98b.b5x2 5.46254237
99b.b5x3 5.72799
100b.b5x5 4.92754115
101b.b5x7 5.6225407
102b.l5x5 6.78629
103b.b6x5 4.466116
104b.l6x5 5.16754204
105b.b7x1 5.69254204
106b.l7x2 3.786529
107b.b8x4 5.52406
108b.l8x3 3.204503
109b.b9x3 4.92406
110b.l9x3 6.618589
111b.l9x6 5.58833608
112b.b10x3 2.758588
113b.b10x5 5.124509
114b.b11x2 3.81587
115b.b11x4 4.45333689
116b.l11x2 6.882589
117b.b12x6 6.45714788
118b.b13x7 6.228577
119b.l13x3 7.05143779
120b.l13x7 4.5975479
121b.b14x1 4.3854128
122b.b14x3 2.98405
123b.b15x1 5.438579
124b.b15x2 4.9446
125b.b15x3 4.2975479
126b.l15x1 5.965127
127b.l15x2 5.834579
128b.b16x4 11.205476
129b.b16x5 5.0375445
130b.b16x6 6.64667678
131b.b17x5 6.188547
132b.b17x7 7.9275448
133b.l17x3 7.86429749
134b.l17x6 7.634129
135b.l17x7 4.785447
136b.b18x3 5.025448
137b.b18x5 4.822545
138b.l18x1 5.74286766
139b.l18x2 5.3075467
140b.b19x2 5.44746
141b.b19x4 4.964548
142b.l19x2 7.6125449
143b.b20x6 8.5175446
144b.b21x1 10.3325447
145b.b21x3 6.355446
146b.b21x7 6.54333605
147b.l21x5 4.465184
148b.b22x5 6.015467
149b.l22x5 4.46429769
150b.b23x3 3.29754147
151b.b23x6 6.901676187
152b.b24x4 8.0645186
153b.b24x6 6.755188
154b.b24x7 4.7469
155b.l24x2 4.975466
156b.l24x3 5.13465
157b.l25x3 7.2225169
158b.b26x3 3.6345146
159b.b27x1 4.19754146
160b.l27x1 8.46857729
161b.l27x2 7.554169
162b.b28x4 6.314166
163b.b28x5 3.72754175
164b.b28x6 8.7954169
165g.h1x11 3.17754159
166g.l1x4 6.2075408
167g.h2x11 8.75466
168g.ctx3 5.905409
169g.ctx15 5.9854179
170g.ctx16 4.594297178
171Lig 6.25286710
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

All columns can be sorted in ascending/descending alphabetical order, clicking on the corresponding column header.

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.


Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
12x46 2x50 19.41032.71YesYes399
22x46 3x43 10.23122.77YesNo398
33x43 7x53 20.75089.38NoYes389
43x50 7x53 10.96426.17YesYes399
53x50 5x58 11.88448.23YesYes099
63x47 5x58 23.68985.09NoYes099
73x47 5x54 43.7196.19NoNo098
85x54 6x44 43.58212.42NoYes089
93x40 6x44 39.87088.21NoYes089
103x40 6x48 39.73296.83NoYes088
116x48 Lig 39.18175.3YesYes080
12E2x52 Lig 12.11497.64NoYes150
13E2 E2x52 11.82892.78YesNo145
143x43 7x49 10.22914.12NoNo389
156x40 7x53 10.95239.58NoYes089
165x58 6x40 11.52575.99YesNo098
175x40 Lig 12.69512.82NoYes150
185x40 E2 11.82839.14NoYes154
196x51 Lig 13.26916.37NoYes170
206x51 E2 11.828112.78NoYes174
211x50 2x50 24.17275.39YesYes399
221x50 2x47 14.68063.13YesNo099
231x53 2x47 13.81743.39NoNo099
241x53 7x54 12.95429.62NoNo097
25b.b26x4 b.b2x3 19.95843.49NoNo056
26b.b26x2 b.b2x3 20.04344.86NoNo076
27b.b26x1 b.b26x2 20.12913.44NoNo097
28b.b26x1 b.l27x1 20.21686.18NoYes099
29G.H3.17 b.l27x1 11.85692.81YesYes259
30G.H3.15 G.H3.17 17.68413.39NoYes285
31G.H3.15 G.H3.18 17.7643.62NoYes289
32G.H2.08 G.H3.18 12.11975.02NoYes089
33G.H2.04 G.H2.08 12.07313.76NoNo098
34G.H2.04 G.H3.08 11.97954.86NoNo099
35G.H3.08 G.S4.04 12.3954.87NoYes099
36G.S4.04 G.S4.06 48.92732.62YesNo097
37G.H4.15 G.S4.06 47.1335.24NoNo087
38G.H3.06 G.H4.15 94.12133.73NoNo068
39G.H3.06 G.hgh4.02 1007.18NoYes067
40G.H3.02 G.hgh4.02 97.47613.59YesYes587
41G.H3.02 G.s4h3.03 97.712618.02YesYes088
42G.S4.07 G.s4h3.03 97.23054.63NoYes088
43G.S4.07 G.s5hg.01 97.10984.82NoYes089
44G.S5.07 G.s5hg.01 96.62674.2NoYes099
45G.S5.07 G.s6h5.01 96.505914.62NoNo099
46G.S5.05 G.s6h5.01 96.38493.89NoNo099
47G.S5.03 G.S5.05 95.29453.77YesNo089
48G.H5.10 G.S5.03 94.93023.25NoYes068
49G.H5.10 G.S6.02 94.80874NoYes067
505x72 G.S6.02 90.257119.16NoYes057
515x72 G.H5.13 89.73511.75NoNo058
525x68 G.H5.13 88.55628.76NoNo068
535x68 G.H5.16 88.43251.54NoNo066
54G.H5.16 G.H5.20 88.30882.85NoYes069
555x65 G.H5.20 87.92279.99NoYes1089
565x65 6x30 87.82792.73NoYes1088
575x62 6x30 87.28835.45YesYes1068
585x62 5x63 87.20763.42YesNo061
595x60 5x63 86.95913.99NoNo041
603x51 5x60 86.83486.57YesNo074
613x51 5x57 64.99575.22YesNo077
623x47 5x57 64.86765.16NoNo097
63G.H3.09 G.S4.04 47.0789.65NoYes1399
64G.H3.09 G.H4.15 47.0997.5NoNo098
657x54 8x50 10.36385.24NoYes078
663x52 I2x56 20.96873.73NoYes047
673x48 3x52 10.62749.31NoNo064
683x48 3x51 10.77163.75NoYes067
693x52 I2x50 10.63143.35NoNo047
703x51 I2x50 11.06410.81YesNo077
712x42 3x49 15.03336.83YesNo388
722x42 3x42 11.73946.19YesYes388
73b.b2x5 b.l4x1 10.51034.94YesNo075
74b.b26x4 b.b2x5 15.8422.81NoYes057
75b.b6x5 b.l6x4 28.27154.35YesNo065
76b.l6x3 b.l6x4 28.80371.86NoNo065
77b.l6x3 b.l6x5 14.66858.94NoYes2064
78b.b7x1 b.l6x5 15.19933.49YesYes2044
79b.b10x5 b.b7x1 32.2433.09YesYes094
80b.b10x5 b.b11x2 33.3536.28YesYes097
81b.b11x2 b.b11x4 47.92293.04YesYes879
82b.b11x4 b.l9x3 48.66155.48YesYes899
83b.b11x6 b.l9x3 97.493313.95NoYes899
84b.b11x6 b.l11x1 99.00073.71NoNo099
85b.l11x1 b.l9x6 99.10995.79NoYes098
86G.H2.02 b.l9x6 57.99955.09NoYes088
87G.H2.02 G.s3h2.03 58.07132.89NoYes089
88G.S3.08 G.s3h2.03 29.07132.87YesYes299
89G.S3.08 G.h2s4.01 29.12342.62YesYes299
90G.S1.05 G.h2s4.01 87.82549.74NoYes099
91G.S1.05 G.S1.07 86.37655.54NoNo099
92G.H3.12 G.S1.07 86.33822.85NoNo089
93G.H3.12 G.S4.04 86.30013.77NoYes089
94b.l10x3 b.l6x3 14.66738.83NoNo2066
95b.b7x1 b.l10x3 14.93278.05YesNo2046
96b.b11x2 b.b12x6 47.94933.52YesYes878
97b.b12x6 b.l9x3 48.5343.17YesYes889
98G.H2.07 G.s3h2.03 29.07129.86NoYes299
99G.H2.07 G.h2s4.01 29.0874.01NoYes299
100b.b6x1 b.l9x6 42.95927.18NoYes098
101b.b6x1 b.l7x2 43.06592.83NoYes099
102b.l5x5 b.l7x2 29.34914.56YesYes299
103G.h2s4.01 b.l5x5 29.74294.01YesYes299
104G.H2.10 b.l7x2 13.89343.17YesYes279
105b.b11x2 b.l12x1 63.70912.94YesNo076
106b.l10x4 b.l12x1 63.40645.66NoNo036
107b.b12x7 b.l10x4 62.89566.73NoNo093
108b.b12x7 b.b13x4 61.87352.89NoNo094
109b.b13x4 b.b13x5 61.61783.14NoNo044
110b.b13x5 b.b13x7 61.10646.49NoYes047
111b.b13x7 b.b15x1 54.58756.43YesYes779
112b.b15x1 b.l16x1 51.08332.62YesNo094
113b.l16x1 b.l16x2 50.82582.62NoNo049
114b.l16x2 b.l16x3 50.31074.65NoNo093
115b.b16x7 b.l16x3 25.15769.09NoNo093
116b.b16x7 b.b17x4 24.637810.72NoNo095
117b.b16x5 b.b17x4 48.75133.64YesNo055
118b.b16x5 b.b17x5 26.73717.99YesYes457
119b.b17x5 b.b21x1 20.97289.14YesYes477
120b.1x18 b.b21x1 18.91211.91NoYes067
121b.1x14 b.1x18 14.71455.01NoNo076
122b.1x14 g.h1x15 14.18963.25NoNo078
123b.1x13 g.h1x15 13.13971.52NoNo048
124b.1x10 b.1x13 12.0897.99YesNo1584
125b.b17x2 b.l16x3 24.89556.77NoNo033
126b.b17x2 b.b17x4 24.63563.72NoNo035
127b.l23x1 b.l25x6 10.911521.44NoNo068
128b.l21x7 b.l23x1 10.68773.11NoNo056
129b.l21x7 b.l23x2 10.46456.22NoNo058
130b.b3x3 b.b6x5 21.34265.05YesYes1186
131b.b3x3 b.b4x3 19.21292.98YesYes1187
132b.b15x2 b.b16x5 20.97142.98YesYes465
1333x49 I2x56 15.2912.83NoYes387
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


2D representation of the interactions of this orthosteric/allosteric ligand.


Links and nodes colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Node1Node2LinkStrengthCommIsNode1Hub?IsNode2Hub?Node1ConsNode2ConsNode1ShellNode2Shell
3x327x423.041YesNo6811
3x32Lig2.971YesYes6010
3x406x486.830NoYes8821
5x39E29.911YesYes6422
E2E284.111YesYes4422
5x40E29.141NoYes5412
E2E2x522.781YesNo4521
E2E2x513.181YesNo4422
6x51E212.781NoYes7412
E2x51E2x524.061NoNo4521
E2x52Lig7.641NoYes5010
7x37E24.331YesYes6422
5x395x405.991YesNo6521
5x40Lig2.821NoYes5010
6x476x485.220NoYes8821
6x487x413.890YesNo8712
6x48Lig5.30YesYes8010
6x517x374.171NoYes7612
6x51Lig16.371NoYes7010
7x42Lig6.561NoYes8010
5x47Lig2.110NoYes8010
2x573x321.70NoYes6621
3x313x321.590NoYes4621

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

ShowSimilarityNetwork TypeNameLigandDescription
100.00Single8IU2Retinal8IU2-Opsin1LW-Retinal-Gi1/β1/γ2
100.00Consensusgi_sensoryOrthosteric Ligandgi_opsins
100.00Consensusopsin1lw_onOrthosteric Ligand8IU2-Opsin1LW-Retinal-Gi1/β1/γ2
100.00Consensusopsin1lw_on_gpOrthosteric Ligand8IU2-Opsin1LW-Retinal-Gi1/β1/γ2
62.50Single7MTBAll-trans-Retinal7MTB-Rhodopsin-All-trans-Retinal-GRK1
62.50Consensusopsins_onOrthosteric Ligandrhodopsin_on opsin1lw_on
62.50Consensussensory_onOrthosteric Ligandopsins_on
60.00Consensussensory_offonOrthosteric Ligandsensory_off sensory_on
60.00Consensussensory_offon_gpOrthosteric Ligandsensory_on_gp sensory_on
58.33Single9AVLCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVL-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi3/β2/γ2
58.33Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
55.56Single3C9M11-cis-Retinal3C9M-Rhodopsin-11-cis-Retinal
55.56Single3PQRAll-trans-Retinal3PQR-Rhodopsin-All-trans-Retinal-Gt(CT)
55.56Single7MT8All-trans-Retinal7MT8-Rhodopsin-All-trans-Retinal-GRK1
55.56Single7MT9All-trans-Retinal7MT9-Rhodopsin-All-trans-Retinal-GRK1
55.56Single7MTAAll-trans-Retinal7MTA-Rhodopsin-All-trans-Retinal-GRK1
55.56Consensusopsins_on_gpOrthosteric Ligandrhodopsin_on_gp opsin1lw_on_gp
55.56Consensusrhodopsin_onOrthosteric Ligand6OYA-Rhodopsin-All-trans-Retinal-Gt/β1/γ1
55.56Consensussensory_on_gpOrthosteric Ligandopsins_on_gp
54.55Single3UZC4-(3-amino-5-phenyl-1,2,4-triazin-6-yl)-2-chlorophenol3UZC-A2A-4-(3-amino-5-phenyl-1,2,4-triazin-6-yl)-2-chlorophenol
54.55Single6WH4Methiothepin6WH4-5-HT2A-Methiothepin
54.55Single9ASBCa; Ca; Cyclomethyltryptophan; 9IG; PO49ASB-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
53.85Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/β1/γ2
50.00Single1L9H11-cis-Retinal1L9H-Rhodopsin-11-cis-Retinal
50.00Single1U1911-cis-Retinal1U19-Rhodopsin-11-cis-Retinal
50.00Single2G87All-trans-Retinal2G87-Rhodopsin-All-trans-Retinal
50.00Single2I3511-cis-Retinal2I35-Rhodopsin-11-cis-Retinal
50.00Single3PXOAll-trans-Retinal3PXO-Rhodopsin-All-trans-Retinal
50.00Single5DYSAll-trans-Retinal5DYS-Rhodopsin-All-trans-Retinal
50.00Single5OLZPubChem 1355666095OLZ-A2A-PubChem 135566609-Na
50.00Single5OM1PubChem 1355666095OM1-A2A-PubChem 135566609-Na
50.00Single5TE520-Methanoretinal5TE5-Rhodopsin-20-Methanoretinal
50.00Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
50.00Single8CU7LJ-45178CU7-A2A-LJ-4517-Na
50.00Single8YH3N-methyladenosine8YH3-A3A-N-methyladenosine-Gi1/β1/γ2
46.15Single5OM4PubChem 1355666095OM4-A2A-PubChem 135566609-Na
46.15Single5X7DS-Carazolol5X7D-β2-S-Carazolol-PubChem 129318963
46.15Single6LUQHaloperidol6LUQ-D2-Haloperidol
46.15Single7SINNPS-21437SIN-CaS-NPS-2143
46.15Single7SINNPS-21437SIN-CaS-NPS-2143
46.15Single8YH0NECA8YH0-A3A-NECA-Gi1/β1/γ2
45.45Single1GZM11-cis-Retinal1GZM-Rhodopsin-11-cis-Retinal
45.45Single2PED9-cis-Retinal2PED-Rhodopsin-9-cis-Retinal
45.45Single3C9L11-cis-Retinal3C9L-Rhodopsin-11-cis-Retinal
45.45Single6D9HAdenosine6D9H-A1-Adenosine-Gi2/β1/γ2
45.45Single6OYAAll-trans-Retinal6OYA-Rhodopsin-All-trans-Retinal-Gt/β1/γ1
45.45Single8A6CAll-trans-Retinal8A6C-Rhodopsin-All-trans-Retinal
45.45Single8A6DAll-trans-Retinal8A6D-Rhodopsin-All-trans-Retinal
45.45Single8A6EAll-trans-Retinal8A6E-Rhodopsin-All-trans-Retinal
45.45Single9C2FCa; Ca; Tryptophan; '6218; PO49C2F-CaS-Ca-Ca; Ca; Tryptophan; '6218; PO4
45.45Consensusrhodopsin_offOrthosteric Ligand1U19-Rhodopsin-11-cis-Retinal 2PED-Rhodopsin-9-cis-Retinal 5TE5-Rhodopsin-20-Methanoretinal
45.45Consensusrhodopsin_on_gpOrthosteric Ligand6OYA-Rhodopsin-All-trans-Retinal-Gt/β1/γ1
44.44Single2HPYAll-trans-Retinal2HPY-Rhodopsin-All-trans-Retinal
44.44Single8GEIConstrained Epinephrine8GEI-β2-Constrained Epinephrine-Gs/β1/γ2
44.44Single8WC5Tetramethylammonium Ion8WC5-TA1-Tetramethylammonium Ion-chim(NtGi1-Gs)/β1/γ2
42.86Single5V54Methiothepin5V54-5-HT1B-Methiothepin
42.86Single6GT3Imaradenant6GT3-A2A-Imaradenant-Na
42.86Single6J21Aprepitant6J21-NK1-Aprepitant
42.86Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/β1/γ2
42.86Consensus5ht1_offOrthosteric Ligand5ht1b_off
42.86Consensus5ht1b_offOrthosteric Ligand5V54-5-HT1B-Methiothepin
42.86Consensustachykinin_offOrthosteric Ligandnk1_off
41.67Single1F8811-cis-Retinal1F88-Rhodopsin-11-cis-Retinal
41.67Single2YDOAdenosine2YDO-A2A-Adenosine
41.67Single3OAX11-cis-Retinal3OAX-Rhodopsin-11-cis-Retinal
41.67Single4DKLBeta-Funaltrexamine4DKL-μ-β-Funaltrexamine
41.67Single4N6HNaltrindole4N6H-δ-Naltrindole-Na
41.67Single7ZBC11-cis-Retinal7ZBC-Rhodopsin-11-cis-Retinal
41.67Single7ZBE11-cis-Retinal7ZBE-Rhodopsin-11-cis-Retinal
41.67Single8FCZ11-cis-Retinal8FCZ-Rhodopsin-11-cis-Retinal
41.67Single8JLNT1AM8JLN-TA1-T1AM-Gs/β1/γ2
41.67Single8UHBRO52563908UHB-TA1-RO5256390-Gs/β1/γ2
41.67Single8W88SEP-3638568W88-TA1-SEP-363856-Gs/β1/γ2
41.67Single8W8BSEP-3638568W8B-5-HT1A-SEP-363856-Gi1/β1/γ2
41.67Single8Y01Retinal8Y01-Opsin1MW-Retinal-Gi1/β1/γ2
41.67Single8YH2Adenosine8YH2-A3A-Adenosine-Gi1/β1/γ2
41.67Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
41.67Single9EPP11,20-Ethanoretinal9EPP-Rhodopsin-11,20-Ethanoretinal-chim(Gi1-CtGq)/β1/γ2
41.67Consensusopsins_offOrthosteric Ligandrhodopsin_off
41.67Consensussensory_offOrthosteric Ligandopsins_off
40.00Single2J4Y11-cis-Retinal2J4Y-Rhodopsin-11-cis-Retinal
40.00Single3UZAGTPL92363UZA-A2A-GTPL9236
40.00Single4OR2FITM4OR2-mGlu1; mGlu1-FITM
40.00Single6FUFAll-trans-Retinal6FUF-Rhodopsin-All-trans-Retinal-Go
40.00Single7EXDLasmiditan7EXD-5-HT1F-Lasmiditan-Gi1/β1/γ2
40.00Single9C1PCa; Tryptophan; '6218; PO49C1P-CaS-Ca-Ca; Tryptophan; '6218; PO4
40.00Consensus5ht1f_onOrthosteric Ligand7EXD-5-HT1F-Lasmiditan-Gi1/β1/γ2
40.00Consensus5ht1f_on_gpOrthosteric Ligand7EXD-5-HT1F-Lasmiditan-Gi1/β1/γ2
40.00Consensusnk1_offOrthosteric Ligand6HLP-NK1-Netupitant 6HLO-NK1-Aprepitant 6HLL-NK1-CP99994 6E59-NK1-L-760735
38.46Single1HZX11-cis-Retinal1HZX-Rhodopsin-11-cis-Retinal
38.46Single3NY8ICI118-5513NY8-β2-ICI118-551
38.46Single3NYAS-Alprenolol3NYA-β2-S-Alprenolol
38.46Single3ZPR4-methyl-2-(piperazin-1-yl)3ZPR-β1-4-methyl-2-(piperazin-1-yl)-Na
38.46Single4EJ4Naltrindole4EJ4-δ-Naltrindole
38.46Single4GBRS-Carazolol4GBR-β2-S-Carazolol
38.46Single4J4QOctyl Beta-D-Glucopyranoside4J4Q-Rhodopsin-Octyl β-D-Glucopyranoside-Gt(CT)
38.46Single4X1HNonyl-Beta-D-Glucopyranoside4X1H-Rhodopsin-Nonyl-β-D-Glucopyranoside-Gt(CT)
38.46Single6WHADB139486WHA-5-HT2A-DB13948-chim(NtGi2L-Gs-CtGq)/β1/γ2
38.46Single7E32Serotonin7E32-5-HT1D-Serotonin-Gi1/β1/γ2
38.46Single7XTC5-CT7XTC-5-HT7-5-CT-Gs/β1/γ2
38.46Single8CICEtrumadenant8CIC-A2A-Etrumadenant-Na
38.46Single8CU6LJ-45178CU6-A2A-LJ-4517
38.46Single8FY85-MeO-DMT8FY8-5-HT1A-5-MeO-DMT-Gi1/β1/γ1
38.46Single8JD0NAM5638JD0-mGlu2; mGlu3-Glutamate-NAM563
38.46Single8JJOAlprenolol8JJO-β2-Alprenolol
38.46Single8RLNLUF58348RLN-A2A-LUF5834
38.46Single8W8ARO52563908W8A-TA1-RO5256390-chim(NtGi1L-Gs)/β1/γ2
38.46Single8YH5Riboprine8YH5-A3A-Riboprine-Gi1/β1/γ2
38.46Single8ZSSRO52633978ZSS-TA1-RO5263397-chim(NtGi1-Gs)/β1/γ2
38.46Single9AVGCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVG-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs)/β1/γ2
38.46Consensus5ht1d_on_gpOrthosteric Ligand7E32-5-HT1D-Serotonin-Gi1/β1/γ2
38.46Consensus5ht7_onOrthosteric Ligand7XTC-5-HT7-5-CT-Gs/β1/γ2
38.46Consensus5ht7_on_gpOrthosteric Ligand7XTC-5-HT7-5-CT-Gs/β1/γ2
38.46Consensusadenosine_on_gpOrthosteric Liganda1_on_gp a2_on_gp a3_on_gp
38.46Consensusdop_offOrthosteric Ligand4EJ4-δ-Naltrindole
38.46Consensusdopamine_offOrthosteric Ligandd2_off d3_off
37.50Single4A4MAll-trans-Retinal4A4M-Rhodopsin-All-trans-Retinal-Gt(CT)
37.50Single4OR2FITM4OR2-mGlu1; mGlu1-FITM
37.50Single5EN0All-trans-Retinal5EN0-Rhodopsin-All-trans-Retinal-Gt(CT)
37.50Consensusd2_offOrthosteric Ligand6CM4-D2-Risperidone 6LUQ-D2-Haloperidol 7DFP-D2-Spiperone
36.36Single3AYMAll-trans-Retinal3AYM-Rhodopsin-All-trans-Retinal
36.36Single3PBLEticlopride3PBL-D3-Eticlopride
36.36Single6HLLCP999946HLL-NK1-CP99994
36.36Single6PH7Nerol6PH7-Rhodopsin-Nerol-Gt(CT)
36.36Single6TQ4PubChem 160468446TQ4-OX1-PubChem 16046844-Na
36.36Single7V68Iperoxo7V68-M4-Iperoxo-PubChem 57664406-Gi1/β1/γ2
36.36Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
36.36Single8W89PEA8W89-TA1-PEA-chim(NtGi1L-Gs)/β1/γ2
36.36Single8Y0NVUF114188Y0N-CXCR3-VUF11418-Go1/β1/γ2
36.36Single9EPRRetinal9EPR-Rhodopsin-Retinal-Gi1/β1/γ2
36.36Consensusd3_offOrthosteric Ligand3PBL-D3-Eticlopride
35.71Single2RH1S-Carazolol2RH1-β2-S-Carazolol
35.71Single2YCWS-Carazolol2YCW-β1-S-Carazolol
35.71Single5D6LS-Carazolol5D6L-β2-S-Carazolol
35.71Single5N2SPSB365N2S-A1-PSB36
35.71Single6GDGNECA6GDG-A2A-NECA-Gs/β1/γ1
35.71Single6HLPNetupitant6HLP-NK1-Netupitant
35.71Single6PS6Timolol6PS6-β2-Timolol
35.71Single7LD3Adenosine7LD3-A1-Adenosine-PubChem 25263603-Gi2/β1/γ2
35.71Single8C9WEtrumadenant8C9W-A2A-Etrumadenant
35.71Single8E9ZIperoxo8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/β1/γ2
35.71Single8SZGCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-chim(NtGi1-Gq)/β1/γ2
35.71Single8XYKVUF106618XYK-CXCR3-VUF10661-Go1/β1/γ2
35.71Single8ZMFA1L108ZMF-5-HT2C-A1L10
35.71Single8ZRKGSK-12922638ZRK-GPR119-GSK-1292263-Gs/β1/γ2
35.71Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/β1/γ2
35.71Consensus5ht1_onOrthosteric Ligand5ht1a_on 5ht1d_on 5ht1e_on 5ht1f_on
35.71Consensus5ht1_on_gpOrthosteric Ligand5ht1a_on_gp 5ht1d_on_gp 5ht1e_on_gp 5ht1f_on_gp
35.71Consensus5ht1e_on_gpOrthosteric Ligand7E33-5-HT1E-BRL-54443-Gi1/β1/γ2 8UGY-5-HT1E-Mianserin-Gi1/β1/γ1 8UH3-5-HT1E-Setiptiline-Gi1/β1/γ1
35.71Consensus5ht2_offOrthosteric Ligand5ht2a_off 5ht2b_off 5ht2c_off
35.71Consensusa1_offOrthosteric Ligand5UEN-A1-DU172 5N2S-A1-PSB36
35.71Consensusadenosine_offOrthosteric Liganda1_off a2_off
35.71Consensusamine_offOrthosteric Ligand5ht_off adrenergic_off dopamine_off histamine_off muscarinic_off
35.71Consensusamine_offonOrthosteric Ligandamine_off amine_on
35.71Consensusamine_offon_gpOrthosteric Ligandamine_on_gp amine_off
35.71Consensusamine_onOrthosteric Ligand5ht_on adrenergic_on dopamine_on histamine_on muscarinic_on trace-amine_on
35.71Consensusbeta2_offOrthosteric Ligand2RH1-β2-S-Carazolol 6PS3-β2-S-Carvedilol 6PS5-β2-S-Propranolol 3D4S-β2-Timolol 3NY8-β2-ICI118-551 3NY9-β2-ICI118-551 6PRZ-β2-S-Alprenolol
35.71Consensusbeta_offOrthosteric Ligandbeta1_off beta2_off
35.71Consensusgi_adrenergicOrthosteric Ligand7EJ0-α2a-L-Norepinephrine-Go/β1/γ2 7EJK-α2a-Oxymetazoline-Go/β1/γ2 7W7E-α2a-PubChem 164946676-Go/β1/γ2 7W6P-α2a-N-pyridin-4-ylisoquinolin-4-amine-Go/β1/γ2 7EJ8-α2a-Brimonidine-Go/β1/γ2 6K42-α2b-Dexmedetomidine-Gi1/β1/γ2 7EJA-α2a-Dexmedetomidine-Go/β1/γ2 7S0F-β1-Isoprenaline-Gi1/β1/γ2
35.71Consensusgq_muscarinicOrthosteric Ligand6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/β1/γ2
35.71Consensusm1_onOrthosteric Ligand6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/β1/γ2
35.71Consensusta1_onOrthosteric Ligand8W87-TA1-METH-chim(NtGi1L-Gs)/β1/γ2 8W89-TA1-PEA-chim(NtGi1L-Gs)/β1/γ2 8JLP-TA1-Ralmitaront-Gs/β1/γ2 8W8A-TA1-RO5256390-chim(NtGi1L-Gs)/β1/γ2 8W88-TA1-SEP-363856-Gs/β1/γ2 8JLO-TA1-Ulotaront-Gs/β1/γ2 8JLR-TA1-A77636-chim(NtGi1-Gs)/β1/γ2 8JSO-TA1-AMPH-chim(NtGi1-Gs)/β1/γ2 8ZSP-TA1-LSD-chim(NtGi1L-Gs-CtGq)/β1/γ2
35.71Consensustrace-amine_onOrthosteric Ligandta1_on
35.29Single3NY9ICI118-5513NY9-β2-ICI118-551
33.33Single2YDVNECA2YDV-A2A-NECA
33.33Single2Z7311-cis-Retinal2Z73-Rhodopsin-11-cis-Retinal
33.33Single3AYN9-cis-Retinal3AYN-Rhodopsin-9-cis-Retinal
33.33Single4UHRCGS216804UHR-A2A-CGS21680
33.33Single5A8E7-Methylcyanopindolol5A8E-β1-7-Methylcyanopindolol-Na
33.33Single5D5AS-Carazolol5D5A-β2-S-Carazolol
33.33Single5D5BS-Carazolol5D5B-β2-S-Carazolol
33.33Single5G53NECA5G53-A2A-NECA-Gs
33.33Single5ZKBAF-DX 3845ZKB-M2-AF-DX 384
33.33Single6J20Aprepitant6J20-NK1-Aprepitant
33.33Single6KUYPubChem 1457046436KUY-α2a-PubChem 145704643
33.33Single6OIJIperoxo6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/β1/γ2
33.33Single6TQ6PubChem 1457142836TQ6-OX1-PubChem 145714283
33.33Single7EJ0L-Norepinephrine7EJ0-α2a-L-Norepinephrine-Go/β1/γ2
33.33Single7LD4Adenosine7LD4-A1-Adenosine-Gi2/β1/γ2
33.33Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
33.33Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
33.33Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
33.33Single7T8XAcetylcholine7T8X-M2-Acetylcholine-chim(NtGi1-Go)/β1/γ2
33.33Single7T90Acetylcholine7T90-M2-Acetylcholine-chim(NtGi1-Go)/β1/γ2
33.33Single7T96Acetylcholine7T96-M2-Acetylcholine-LY2119620-Go/β1/γ2
33.33Single7W6PN-pyridin-4-ylisoquinolin-4-amine7W6P-α2a-N-pyridin-4-ylisoquinolin-4-amine-Go/β1/γ2
33.33Single7W7EPubChem 1649466767W7E-α2a-PubChem 164946676-Go/β1/γ2
33.33Single7XY7NECA7XY7-A2B-NECA-chim(NtGi1-Gs)/β1/γ2
33.33Single7YM8Oxymetazoline7YM8-Alpha1A-Oxymetazoline-chim(Gs-CtGq)
33.33Single7YMHNorepinephrine7YMH-Alpha1A-Norepinephrine-chim(Gs-CtGq)
33.33Single8DCSCyanopindolol8DCS-β1-Cyanopindolol-Gs/β1/γ2
33.33Single8DU3PubChem 1055260648DU3-A2A-PubChem 105526064
33.33Single8EA0Iperoxo8EA0-M3-Iperoxo
33.33Single8GGAConstrained Epinephrine8GGA-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
33.33Single8GGCConstrained Epinephrine8GGC-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
33.33Single8GGRConstrained Epinephrine8GGR-β2-Constrained Epinephrine
33.33Single8GGWConstrained Epinephrine8GGW-β2-Constrained Epinephrine
33.33Single8GGZConstrained Epinephrine8GGZ-β2-Constrained Epinephrine
33.33Single8GH0Constrained Epinephrine8GH0-β2-Constrained Epinephrine
33.33Single8HDPAdenosine8HDP-A2B-Adenosine-Gs/β1/γ2
33.33Single8HOCImetit8HOC-H4-Imetit-Gi1/β1/γ2
33.33Single8IRRRotigotine8IRR-D1-Rotigotine-Gs/β1/γ2
33.33Single8IW4Spermidine8IW4-TA9-Spermidine-chim(NtGi1-Gs)/β1/γ2
33.33Single8IWESpermidine8IWE-TA9-Spermidine
33.33Single8JXXClobenpropit8JXX-H4-Clobenpropit-Gi1/β1/γ2
33.33Single8SZICa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZI-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi3/β1/γ2
33.33Single8T1VPubChem 1183102098T1V-GPR6-PubChem 118310209-Na
33.33Single8UNXConstrained Epinephrine8UNX-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
33.33Single8WC3SEP-3638568WC3-TA1-SEP-363856-chim(NtGi1-Gs)/β1/γ2
33.33Single8XXVIndomethacin8XXV-DP2-Indomethacin-A1D5Q-Gi1/β1/γ2
33.33Single8Y0HVUF114188Y0H-CXCR3-VUF11418
33.33Single8YH6Namodenoson8YH6-A3A-Namodenoson-Gi1/β1/γ2
33.33Single8YNAImmepip8YNA-H4-Immepip-Gi1/β1/γ
33.33Single9MQJIsoquinuclidine9MQJ-μ-Isoquinuclidine
33.33Consensus5ht1e_onOrthosteric Ligand7E33-5-HT1E-BRL-54443-Gi1/β1/γ2 8UGY-5-HT1E-Mianserin-Gi1/β1/γ1 8UH3-5-HT1E-Setiptiline-Gi1/β1/γ1
33.33Consensus5ht_offOrthosteric Ligand5ht2_off 5ht1_off
33.33Consensusa1_onOrthosteric Ligand7LD4-A1-Adenosine-Gi2/β1/γ2
33.33Consensusa1_on_gpOrthosteric Ligand7LD4-A1-Adenosine-Gi2/β1/γ2
33.33Consensusa2_onOrthosteric Liganda2b_on
33.33Consensusa2_on_gpOrthosteric Liganda2b_on_gp
33.33Consensusa2b_onOrthosteric Ligand8HDP-A2B-Adenosine-Gs/β1/γ2 7XY6-A2B-BAY 60-6583-chim(NtGi1-Gs)/β1/γ2 7XY7-A2B-NECA-chim(NtGi1-Gs)/β1/γ2 8HDO-A2B-BAY 60-6583-Gs/β1/γ2
33.33Consensusa2b_on_gpOrthosteric Ligand8HDP-A2B-Adenosine-Gs/β1/γ2 7XY6-A2B-BAY 60-6583-chim(NtGi1-Gs)/β1/γ2 7XY7-A2B-NECA-chim(NtGi1-Gs)/β1/γ2 8HDO-A2B-BAY 60-6583-Gs/β1/γ2
33.33Consensusalpha2_offOrthosteric Ligandalpha2c_off
33.33Consensusamine_on_gpOrthosteric Ligand5ht_on_gp adrenergic_on_gp dopamine_on_gp histamine_on_gp muscarinic_on_gp trace-amine_on_gp
33.33Consensusbeta1_offOrthosteric Ligand2VT4-β1-Cyanopindolol 2YCW-β1-S-Carazolol 2YCZ-β1-Iodocyanopindolol 5A8E-β1-7-Methylcyanopindolol-Na 3ZPQ-β1-4-(piperazin-1- yl)-1H-indole-Na 3ZPR-β1-4-methyl-2-(piperazin-1-yl)-Na
33.33Consensusclass-a_offOrthosteric Ligandsensory_off alicarboxylic_off amine_off lipid_off nucleotide_off peptide_off protein_off
33.33Consensusgs_adenosineOrthosteric Ligand8HDP-A2B-Adenosine-Gs/β1/γ2 8HDO-A2B-BAY 60-6583-Gs/β1/γ2 7XY7-A2B-NECA-chim(NtGi1-Gs)/β1/γ2 7XY6-A2B-BAY 60-6583-chim(NtGi1-Gs)/β1/γ2
33.33Consensusgs_nucleotideOrthosteric Ligandgs_adenosine
33.33Consensusm1_on_gpOrthosteric Ligand6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/β1/γ2
33.33Consensusm2_onOrthosteric Ligand7T8X-M2-Acetylcholine-chim(NtGi1-Go)/β1/γ2
33.33Consensusm2_on_gpOrthosteric Ligand7T8X-M2-Acetylcholine-chim(NtGi1-Go)/β1/γ2
33.33Consensusmop_offOrthosteric Ligand4DKL-μ-β-Funaltrexamine 8QOT-μ-Nanobody-E 7UL4-μ-Alvimopan
33.33Consensusta1_on_gpOrthosteric Ligand8W87-TA1-METH-chim(NtGi1L-Gs)/β1/γ2 8W89-TA1-PEA-chim(NtGi1L-Gs)/β1/γ2 8JLP-TA1-Ralmitaront-Gs/β1/γ2 8W8A-TA1-RO5256390-chim(NtGi1L-Gs)/β1/γ2 8W88-TA1-SEP-363856-Gs/β1/γ2 8JLO-TA1-Ulotaront-Gs/β1/γ2 8JLR-TA1-A77636-chim(NtGi1-Gs)/β1/γ2 8JSO-TA1-AMPH-chim(NtGi1-Gs)/β1/γ2 8ZSP-TA1-LSD-chim(NtGi1L-Gs-CtGq)/β1/γ2
33.33Consensustrace-amine_on_gpOrthosteric Ligandta1_on_gp
31.58Single3QAKUK-4320973QAK-A2A-UK-432097
31.58Single6HLOAprepitant6HLO-NK1-Aprepitant
31.25Single2YCXCyanopindolol2YCX-β1-Cyanopindolol
31.25Single3D4STimolol3D4S-β2-Timolol
31.25Single4AMIBucindolol4AMI-β1-Bucindolol
31.25Single5F8UCyanopindolol5F8U-β1-Cyanopindolol
31.25Single6CM4Risperidone6CM4-D2-Risperidone
31.25Single6H7NS-Xamoterol6H7N-β1-S-Xamoterol
31.25Single6H7OCyanopindolol6H7O-β1-Cyanopindolol
31.25Single7DFPSpiperone7DFP-D2-Spiperone
31.25Single7K15MKD0467K15-BLT1-MKD046-Na
31.25Single7MTRADX551647MTR-mGlu2; mGlu2-Glutamate-ADX55164
31.25Single7WCNAR2314537WCN-GPR119-AR231453-Gs/β1/γ2
31.25Single7XMTJ-21567XMT-SST4-J-2156-Gi1/β1/γ2
31.25Single7YITNalfurafine7YIT-κ-Nalfurafine
31.25Single8FYE4-F,5-MeO-PyrT8FYE-5-HT1A-4-F,5-MeO-PyrT-Gi1/β1/γ1
31.25Single8FYTLSD8FYT-5-HT1A-LSD-Gi1/β1/γ1
31.25Single8ID9Eicosapentaenoic acid8ID9-FFA4-Eicosapentaenoic acid-Gi1/β1/γ2
31.25Single8JD3HZR; PEF8JD3-mGlu2; mGlu3-Glutamate-HZR; PEF-Gi1/β1/γ2
31.25Single8T3QDocosa-4,7,10,13,16,19-Hexaenoic acid8T3Q-FFA4-Docosa-4,7,10,13,16,19-Hexaenoic acid-chim(NtGi2L-Gs-CtGq)/β1/γ2
31.25Single8VHFMBX-29828VHF-GPR119-MBX-2982-Gs/β1/γ2
31.25Single8XYIVUF106618XYI-CXCR3-VUF10661
31.25Single9GYOP3959GYO-GPBA-P395-chim(NtGi1-Gs)/β1/γ2
31.25Consensusopioid_offOrthosteric Ligandmop_off nop_off dop_off kop_off
30.77Single4LDOL-Epinephrine4LDO-β2-L-Epinephrine
30.77Single5IU7Q274563465IU7-A2A-Q27456346-Na
30.77Single5JTBZM-2413855JTB-A2A-ZM-241385
30.77Single5TE3Octyl-Beta-D-Glucopyranoside5TE3-Rhodopsin-Octyl-β-D-Glucopyranoside
30.77Single5UVIZM-2413855UVI-A2A-ZM-241385
30.77Single6A94Zotepine6A94-5-HT2A-Zotepine
30.77Single6AQFZM-2413856AQF-A2A-ZM-241385
30.77Single6K41Dexmedetomidine6K41-α2b-Dexmedetomidine-Go/β1/γ2
30.77Single6KUXRS-799486KUX-α2a-RS-79948
30.77Single6MH8ZM-2413856MH8-A2A-ZM-241385
30.77Single6PELCitronellol6PEL-Rhodopsin-Citronellol-Gt(CT)
30.77Single6PS0S-Carazolol6PS0-β2-S-Carazolol
30.77Single6PS4ICI118-5516PS4-β2-ICI118-551
30.77Single6TPKRetosiban6TPK-OT-Retosiban
30.77Single6V9SGTPL114036V9S-OX1-GTPL11403
30.77Single6ZDRHMS1413f126ZDR-A2A-HMS1413f12-Na
30.77Single7AROLUF58337ARO-A2A-LUF5833-Na
30.77Single7CMVPD1289077CMV-D3-PD128907-Gi1/β1/γ2
30.77Single7DHISalbutamol7DHI-β2-Salbutamol-Gs/β1/γ2
30.77Single7E33BRL-544437E33-5-HT1E-BRL-54443-Gi1/β1/γ2
30.77Single7EJ8Brimonidine7EJ8-α2a-Brimonidine-Go/β1/γ2
30.77Single7EJADexmedetomidine7EJA-α2a-Dexmedetomidine-Go/β1/γ2
30.77Single7T94Acetylcholine7T94-M2-Acetylcholine-PubChem 57664406-chim(NtGi1-Go)/β1/γ2
30.77Single7TRSAcetylcholine7TRS-M4-Acetylcholine-Gi1/β1/γ2
30.77Single7VODCariprazine7VOD-5-HT2A-Cariprazine
30.77Single7WC9PubChem 1624213647WC9-5-HT2A-PubChem 162421364
30.77Single8GE1Constrained Epinephrine8GE1-β2-Constrained Epinephrine-Gs/β1/γ2
30.77Single8GE4Constrained Epinephrine8GE4-β2-Constrained Epinephrine-Gs/β1/γ2
30.77Single8GE6Constrained Epinephrine8GE6-β2-Constrained Epinephrine-Gs/β1/γ2
30.77Single8GE7Constrained Epinephrine8GE7-β2-Constrained Epinephrine-Gs/β1/γ2
30.77Single8GE8Constrained Epinephrine8GE8-β2-Constrained Epinephrine-Gs/β1/γ2
30.77Single8GEAConstrained Epinephrine8GEA-β2-Constrained Epinephrine-Gs/β1/γ2
30.77Single8GEDConstrained Epinephrine8GED-β2-Constrained Epinephrine-Gs/β1/γ2
30.77Single8GEFConstrained Epinephrine8GEF-β2-Constrained Epinephrine-Gs/β1/γ2
30.77Single8GG8Constrained Epinephrine8GG8-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
30.77Single8GGQConstrained Epinephrine8GGQ-β2-Constrained Epinephrine
30.77Single8GGSConstrained Epinephrine8GGS-β2-Constrained Epinephrine
30.77Single8GGTConstrained Epinephrine8GGT-β2-Constrained Epinephrine
30.77Single8GGVConstrained Epinephrine8GGV-β2-Constrained Epinephrine
30.77Single8GGXConstrained Epinephrine8GGX-β2-Constrained Epinephrine
30.77Single8HNMVUF112228HNM-CXCR3-VUF11222-Gi1/β1/γ2
30.77Single8JLKUlotaront8JLK-TA1-Ulotaront-chim(NtGi1-Gs)/β1/γ2
30.77Single8JSPUlotaront8JSP-5-HT1A-Ulotaront-Gi1/β1/γ2
30.77Single8PM2DMCH8PM2-TA7-DMCH-Gs/β1/γ2
30.77Single8RQQZM-2413858RQQ-A2A-ZM-241385-Na
30.77Single8RWCStilSwitch28RWC-A2A-StilSwitch2-Na
30.77Single8RWDStilSwitch38RWD-A2A-StilSwitch3-Na
30.77Single8THKA616038THK-Alpha1A-A61603-chim(NtGi2L-Gs-CtGq)/β1/γ2
30.77Single8THLEpinephrine8THL-Alpha1A-Epinephrine-chim(NtGi2L-Gs-CtGq)/β1/γ2
30.77Single8U02L-Dopamine8U02-D2-L-Dopamine-Go/β1/γ2
30.77Single8UNMConstrained Epinephrine8UNM-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
30.77Single8UNWConstrained Epinephrine8UNW-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
30.77Single8UO0Constrained Epinephrine8UO0-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
30.77Single8WC8ZH86518WC8-TA1-ZH8651-chim(NtGi1-Gs)/β1/γ2
30.77Single8Y45ADL58598Y45-δ-ADL5859-Gi2/β1/γ2
30.77Single8YN3Histamine8YN3-H2-Histamine-Gs/β1/γ2
30.77Single9MQIIsoquinuclidine9MQI-μ-Isoquinuclidine
30.77Consensus5ht2a_offOrthosteric Ligand6A94-5-HT2A-Zotepine 6A93-5-HT2A-Risperidone 7VOD-5-HT2A-Cariprazine 7WC8-5-HT2A-Lumateperone 8JT8-5-HT2A-(R)-IHCH-7179
30.77Consensusa2_offOrthosteric Liganda2a_off
30.77Consensusa2a_offOrthosteric Ligand3RFM-A2A-Caffeine 8C9W-A2A-Etrumadenant 3UZA-A2A-GTPL9236 8GNG-A2A-Istradefylline 8CU6-A2A-LJ-4517 7PX4-A2A-PSB-2113 7PYR-A2A-PSB-2115 8DU3-A2A-PubChem 105526064 8JWY-A2A-2-118 8PWN-A2A-Theophylline 5IU4-A2A-ZM-241385-Na 5OLZ-A2A-PubChem 135566609-Na 6GT3-A2A-Imaradenant-Na 5OLV-A2A-LUAA41063-Na 5N2R-A2A-PSB-36-Na 5IU7-A2A-Q27456346-Na 5OLH-A2A-Vipadenant-Na 5OLO-A2A-Tozadenant-Na 6ZDR-A2A-HMS1413f12-Na 8GNE-A2A-KW-6356-Na 8JWZ-A2A-AB928-Na 5IU8-A2A-Q27456347-Na 5IUB-A2A-Q27456344-Na 6ZDV-A2A-Chromone 5d-Na 5IUA-A2A-Q27456348-Na 8A2P-A2A-LUAA47070-Na
30.77Consensusadenosine_onOrthosteric Liganda1_on a2_on a3_on
30.77Consensusalpha1_onOrthosteric Ligandalpha1a_on
30.77Consensusalpha1_on_gpOrthosteric Ligandalpha1a_on_gp
30.77Consensusalpha1a_onOrthosteric Ligand7EJ0-α2a-L-Norepinephrine-Go/β1/γ2 7EJ8-α2a-Brimonidine-Go/β1/γ2 7EJA-α2a-Dexmedetomidine-Go/β1/γ2 7EJK-α2a-Oxymetazoline-Go/β1/γ2 7W6P-α2a-N-pyridin-4-ylisoquinolin-4-amine-Go/β1/γ2 7W7E-α2a-PubChem 164946676-Go/β1/γ2
30.77Consensusalpha1a_on_gpOrthosteric Ligand7EJ0-α2a-L-Norepinephrine-Go/β1/γ2 7EJ8-α2a-Brimonidine-Go/β1/γ2 7EJA-α2a-Dexmedetomidine-Go/β1/γ2 7EJK-α2a-Oxymetazoline-Go/β1/γ2 7W6P-α2a-N-pyridin-4-ylisoquinolin-4-amine-Go/β1/γ2 7W7E-α2a-PubChem 164946676-Go/β1/γ2
30.77Consensusgi_adenosineOrthosteric Ligand7LD4-A1-Adenosine-Gi2/β1/γ2 8X17-A3A-Namodenoson-Gi1/β1/γ2 8X16-A3A-Piclidenoson-Gi1/β1/γ2
30.77Consensusot_offOrthosteric Ligand6TPK-OT-Retosiban
30.77Consensusvasop-oxy_offOrthosteric Ligandot_off
30.00Single3RFMCaffeine3RFM-A2A-Caffeine
30.00Single6OY9All-trans-Retinal6OY9-Rhodopsin-All-trans-Retinal-Gt/β1/γ1
30.00Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
30.00Single8DPHLorcaserin8DPH-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/β1/γ2
30.00Single8IWM2-Phenylethylamine8IWM-TA9-2-Phenylethylamine
29.41Single2YCZIodocyanopindolol2YCZ-β1-Iodocyanopindolol
29.41Single4BVNCyanopindolol4BVN-β1-Cyanopindolol-Na
29.41Single5TUDErgotamine5TUD-5-HT2B-Ergotamine
29.41Single6BQHRitanserin6BQH-5-HT2C-Ritanserin
29.41Single7JVRBromoergocryptine7JVR-D2-Bromoergocryptine-Gi1/β1/γ2
29.41Single7MTSADX551647MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/β1/γ2
29.41Single7XJISolabegron7XJI-β3-Solabegron-Gs/β1/γ2
29.41Single7XZ6APD6687XZ6-GPR119-APD668-Gs/β1/γ2
29.41Single8E9YClozapine-N-oxide8E9Y-M3-Clozapine-N-oxide-chim(NtGi2L-Gs-CtGq)/β1/γ2
29.41Single8T3OTUG-8918T3O-FFA4-TUG-891-2Y5-chim(NtGi2L-Gs-CtGq)/β1/γ2
29.41Single8XIOL7975918XIO-SST1-L797591-chim(NtGi1-Gs-CtGi1)/β1/γ2
29.41Consensus5ht2c_offOrthosteric Ligand6BQH-5-HT2C-Ritanserin
28.57Single2VT4Cyanopindolol2VT4-β1-Cyanopindolol
28.57Single2Y01Dobutamine2Y01-β1-Dobutamine
28.57Single2Y04Salbutamol2Y04-β1-Salbutamol
28.57Single2YCYCyanopindolol2YCY-β1-Cyanopindolol
28.57Single3EMLZM-2413853EML-A2A-ZM-241385
28.57Single3ZPQ4-(piperazin-1- yl)-1H-indole3ZPQ-β1-4-(piperazin-1- yl)-1H-indole-Na
28.57Single4EIYZM-2413854EIY-A2A-ZM-241385-Na
28.57Single4QKX35V4QKX-β2-35V
28.57Single4U16N-Methyl-Scopolamine4U16-M3-N-Methyl-Scopolamine
28.57Single5IU8Q274563475IU8-A2A-Q27456347-Na
28.57Single5K2AZM-2413855K2A-A2A-ZM-241385-Na
28.57Single5OLGZM-2413855OLG-A2A-ZM-241385-Na
28.57Single5TGZAM65385TGZ-CB1-AM6538
28.57Single5UENDU1725UEN-A1-DU172
28.57Single5VRAZM-2413855VRA-A2A-ZM-241385-Na
28.57Single5YC8N-Methyl-Scopolamine5YC8-M2-N-Methyl-Scopolamine
28.57Single5ZK8N-Methyl-Scopolamine5ZK8-M2-N-Methyl-Scopolamine
28.57Single5ZKCN-Methyl-Scopolamine5ZKC-M2-N-Methyl-Scopolamine
28.57Single6DRZMethysergide6DRZ-5-HT2B-Methysergide
28.57Single6H7MSalbutamol6H7M-β1-Salbutamol
28.57Single6K42Dexmedetomidine6K42-α2b-Dexmedetomidine-Gi1/β1/γ2
28.57Single6PRZS-Alprenolol6PRZ-β2-S-Alprenolol
28.57Single6PS1Timolol6PS1-β2-Timolol
28.57Single6PS2S-Alprenolol6PS2-β2-S-Alprenolol
28.57Single6S0LZM-2413856S0L-A2A-ZM-241385
28.57Single7BTSL-Epinephrine7BTS-β1-L-Epinephrine
28.57Single7BU6L-Norepinephrine7BU6-β1-L-Norepinephrine
28.57Single7BU7BI1671077BU7-β1-BI167107
28.57Single7CFMP3957CFM-GPBA-P395-Gs/β1/γ2
28.57Single7DB6Ramelteon7DB6-MT1-Ramelteon-Gi1/β1/γ2
28.57Single7M3JNPS-2143; PO47M3J-CaS-NPS-2143; PO4
28.57Single7PYRPSB-21157PYR-A2A-PSB-2115
28.57Single7S0GIsoprenaline7S0G-β1-Isoprenaline-chim(Gi1-CtGs)/β1/γ2
28.57Single7UL4Alvimopan7UL4-μ-Alvimopan
28.57Single7UM55-CT7UM5-5-HT5A-5-CT-chim(NtGi1-Go)/β1/γ2
28.57Single7WC7Lisuride7WC7-5-HT2A-Lisuride
28.57Single7WC8Lumateperone7WC8-5-HT2A-Lumateperone
28.57Single7YACPaltusotine7YAC-SST2-Paltusotine-Gi1/β1/γ2
28.57Single8GE3Constrained Epinephrine8GE3-β2-Constrained Epinephrine-Gs/β1/γ2
28.57Single8GE9Constrained Epinephrine8GE9-β2-Constrained Epinephrine-Gs/β1/γ2
28.57Single8GECConstrained Epinephrine8GEC-β2-Constrained Epinephrine-Gs/β1/γ2
28.57Single8GEEConstrained Epinephrine8GEE-β2-Constrained Epinephrine-Gs/β1/γ2
28.57Single8GEHConstrained Epinephrine8GEH-β2-Constrained Epinephrine-Gs/β1/γ2
28.57Single8GFVConstrained Epinephrine8GFV-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
28.57Single8GFWConstrained Epinephrine8GFW-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
28.57Single8GFXConstrained Epinephrine8GFX-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
28.57Single8GFZConstrained Epinephrine8GFZ-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
28.57Single8GG0Constrained Epinephrine8GG0-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
28.57Single8GG1Constrained Epinephrine8GG1-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
28.57Single8GG3Constrained Epinephrine8GG3-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
28.57Single8GG4Constrained Epinephrine8GG4-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
28.57Single8GG6Constrained Epinephrine8GG6-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
28.57Single8GG9Constrained Epinephrine8GG9-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
28.57Single8GGIConstrained Epinephrine8GGI-β2-Constrained Epinephrine
28.57Single8GGJConstrained Epinephrine8GGJ-β2-Constrained Epinephrine
28.57Single8GGKConstrained Epinephrine8GGK-β2-Constrained Epinephrine
28.57Single8GGNConstrained Epinephrine8GGN-β2-Constrained Epinephrine
28.57Single8GGOConstrained Epinephrine8GGO-β2-Constrained Epinephrine
28.57Single8GGUConstrained Epinephrine8GGU-β2-Constrained Epinephrine
28.57Single8JLJT1AM8JLJ-TA1-T1AM-chim(NtGi1-Gs)/β1/γ2
28.57Single8JT8(R)-IHCH-71798JT8-5-HT2A-(R)-IHCH-7179
28.57Single8JXRLSD8JXR-D1-LSD
28.57Single8PJKST1718PJK-5-HT1A-ST171-t7m-Gi1/β1/γ1
28.57Single8RW7StilSwitch18RW7-A2A-StilSwitch1-Na
28.57Single8T1WCVN4248T1W-GPR6-CVN424
28.57Single8UGYMianserin8UGY-5-HT1E-Mianserin-Gi1/β1/γ1
28.57Single8UH3Setiptiline8UH3-5-HT1E-Setiptiline-Gi1/β1/γ1
28.57Single8UNQConstrained Epinephrine8UNQ-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
28.57Single8UNRConstrained Epinephrine8UNR-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
28.57Single8UNUConstrained Epinephrine8UNU-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
28.57Single8UNVConstrained Epinephrine8UNV-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
28.57Single8UNYConstrained Epinephrine8UNY-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
28.57Single8UNZConstrained Epinephrine8UNZ-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
28.57Single8UO2Constrained Epinephrine8UO2-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
28.57Single8W87METH8W87-TA1-METH-chim(NtGi1L-Gs)/β1/γ2
28.57Single8X17Namodenoson8X17-A3A-Namodenoson-Gi1/β1/γ2
28.57Single8X64Desloratadine8X64-H1-Desloratadine
28.57Single8XVKAmbrisentan8XVK-ETA-Ambrisentan
28.57Single9CBMDexmedetomidine9CBM-α2a-Dexmedetomidine-Gi1/β1/γ2
28.57Single9CHXS-Carazolol9CHX-β2-S-Carazolol
28.57Consensus5ht2b_offOrthosteric Ligand6DRZ-5-HT2B-Methysergide
28.57Consensusa3_onOrthosteric Liganda3a_on
28.57Consensusadrenergic_onOrthosteric Ligandalpha_on beta_on
28.57Consensusalpha2_onOrthosteric Ligandalpha2b_on
28.57Consensusalpha2_on_gpOrthosteric Ligandalpha2b_on_gp
28.57Consensusalpha2b_onOrthosteric Ligand6K42-α2b-Dexmedetomidine-Gi1/β1/γ2
28.57Consensusalpha2b_on_gpOrthosteric Ligand6K42-α2b-Dexmedetomidine-Gi1/β1/γ2
28.57Consensusalpha_onOrthosteric Ligandalpha1_on alpha2_on
28.57Consensusd5_onOrthosteric Ligand8IRV-D5-Rotigotine-chim(NtGi1-Gs)/β1/γ2
28.57Consensusdopamine_onOrthosteric Ligandd2_on d1_on d3_on d4_on d5_on
28.57Consensusdopamine_on_gpOrthosteric Ligandd2_on_gp d1_on_gp d3_on_gp d4_on_gp d5_on_gp
28.57Consensusgi_histamineOrthosteric Ligand8JXX-H4-Clobenpropit-Gi1/β1/γ2 8JXV-H4-Clozapine-Gi1/β1/γ2 8YUU-H3-Histamine-Gi1/β1/γ1 8HN8-H4-Histamine-Gi1/β1/γ2 8HOC-H4-Imetit-Gi1/β1/γ2 8JXW-H4-VUF6884-Gi1/β1/γ2
28.57Consensusgq_amineOrthosteric Ligandgq_muscarinic gq_histamine
28.57Consensusgs_trace-amineOrthosteric Ligand8W88-TA1-SEP-363856-Gs/β1/γ2 8JLJ-TA1-T1AM-chim(NtGi1-Gs)/β1/γ2 8JLO-TA1-Ulotaront-Gs/β1/γ2 8WC4-TA1-ZH8651-chim(NtGi1-Gs)/β1/γ2 8WC7-TA1-ZH8667-chim(NtGi1-Gs)/β1/γ2 8JLR-TA1-A77636-chim(NtGi1-Gs)/β1/γ2 8JSO-TA1-AMPH-chim(NtGi1-Gs)/β1/γ2 8W87-TA1-METH-chim(NtGi1L-Gs)/β1/γ2 8W89-TA1-PEA-chim(NtGi1L-Gs)/β1/γ2 8JLP-TA1-Ralmitaront-Gs/β1/γ2 8W8A-TA1-RO5256390-chim(NtGi1L-Gs)/β1/γ2
28.57Consensusmuscarinic_onOrthosteric Ligandm2_on m3_on m4_on m1_on
28.57Consensusmuscarinic_on_gpOrthosteric Ligandm2_on_gp m3_on_gp m4_on_gp m1_on_gp
27.78Single4UG2CGS216804UG2-A2A-CGS21680
27.78Single6G79Donitriptan6G79-5-HT1B-Donitriptan-Go/β1/γ2
27.78Single6PT3DPI-2876PT3-δ-DPI-287
27.78Single7T11Octreotide7T11-SST2-Octreotide-Gi3/β1/γ2
27.78Single8JLRA776368JLR-TA1-A77636-chim(NtGi1-Gs)/β1/γ2
27.78Single8XZFWN5618XZF-Apelin-WN561-Gi1/β1/γ2
27.78Consensuscxcr3_onOrthosteric Ligand8HNK-CXCR3-CXCL11-Gi1/β1/γ2 8HNL-CXCR3-PS372424-Gi1/β1/γ2
27.27Single2ZIY11-cis-Retinal2ZIY-Rhodopsin-11-cis-Retinal
27.27Single5WKTOctyl-Beta-D-Glucopyranoside5WKT-Rhodopsin-Octyl-β-D-Glucopyranoside-Gt(CT)
27.27Single7EJKOxymetazoline7EJK-α2a-Oxymetazoline-Go/β1/γ2
27.27Single7F23Dopamine7F23-D1-Dopamine-GDP-Gs/β1/γ2
27.27Single8ITFDMCHA8ITF-TA9-DMCHA-chim(NtGi1-Gs)/β1/γ2
27.27Single8IW72-Phenylethylamine8IW7-TA9-2-Phenylethylamine-chim(NtGi1-Gs)/β1/γ2
27.27Single8J6QBeta-Hydroxybutyrate8J6Q-HCA2-β-Hydroxybutyrate-Compound 9n-Gi1/β1/γ2
27.27Single8JXTHistamine8JXT-H4-Histamine-PO4-Gi1/β1/γ2
27.27Single8POKHistamine8POK-H2-Histamine-Gs/β1/γ2
27.27Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
27.27Single8WC62-Phenylethylamine8WC6-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/β1/γ2
27.27Single8WC9ZH86518WC9-TA1-ZH8651-chim(NtGi1-Gs-CtGq)/β1/γ2
27.27Single8YN9Histamine8YN9-H4-Histamine-Gi1/β1/γ2
27.27Single8YUUHistamine8YUU-H3-Histamine-Gi1/β1/γ1
27.27Single9C1PCa; Tryptophan; '6218; PO49C1P-CaS-Ca-Ca; Tryptophan; '6218; PO4
27.27Consensush2_on_gpOrthosteric Ligand8POK-H2-Histamine-Gs/β1/γ2
27.27Consensush3_onOrthosteric Ligand8YUU-H3-Histamine-Gi1/β1/γ1
27.27Consensush3_on_gpOrthosteric Ligand8YUU-H3-Histamine-Gi1/β1/γ1
26.67Single2Y00Dobutamine2Y00-β1-Dobutamine
26.67Single2Y03Isoprenaline2Y03-β1-Isoprenaline
26.67Single4WW3All-trans-Retinal4WW3-Rhodopsin-All-trans-Retinal
26.67Single5CGCHTL142425CGC-mGlu5-HTL14242
26.67Single5IUAQ274563485IUA-A2A-Q27456348-Na
26.67Single5JQHS-Carazolol5JQH-β2-S-Carazolol
26.67Single5N2RPSB-365N2R-A2A-PSB-36-Na
26.67Single5NM2ZM-2413855NM2-A2A-ZM-241385-Na
26.67Single5WIUNemonapride5WIU-D4-Nemonapride
26.67Single5WIVNemonapride5WIV-D4-Nemonapride-Na
26.67Single6KUWPubChem 572132346KUW-α2c-PubChem 57213234
26.67Single6LPLZM-2413856LPL-A2A-ZM-241385-Na
26.67Single6ME72-Phenylmelatonin6ME7-MT2-2-Phenylmelatonin
26.67Single6OIKIperoxo6OIK-M2-Iperoxo-LY2119620-chim(NtGi1-Go)/β1/γ2
26.67Single6PS3S-Carvedilol6PS3-β2-S-Carvedilol
26.67Single6S0QZM-2413856S0Q-A2A-ZM-241385
26.67Single6TO7Suvorexant6TO7-OX1-Suvorexant-Na
26.67Single6W2XPubChem 237279706W2X-GABAB1, GABAB2-PubChem 5311042-PubChem 23727970
26.67Single6WQAZM-2413856WQA-A2A-ZM-241385-Na
26.67Single6XBKCholesterol6XBK-SMO-Cholesterol-Gi1/β1/γ2
26.67Single7BVQS-Carazolol7BVQ-β1-S-Carazolol
26.67Single7C61Ergotamine7C61-5-HT1B-Ergotamine
26.67Single7E9GJNJ-404118137E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/β1/γ2
26.67Single7EPFNAM5977EPF-mGlu2; mGlu2-NAM597
26.67Single7M3JNPS-2143; PO47M3J-CaS-NPS-2143; PO4
26.67Single7RM5ZM-2413857RM5-A2A-ZM-241385-Na
26.67Single7S0FIsoprenaline7S0F-β1-Isoprenaline-Gi1/β1/γ2
26.67Single7VOEAripiprazole7VOE-5-HT2A-Aripiprazole
26.67Single7W41PD1762527W41-BB2-PD176252
26.67Single7WC6LSD7WC6-5-HT2A-LSD
26.67Single7X1TTaltirelin7X1T-TRH-Taltirelin-chim(NtGi2L-Gs-CtGq)/β1/γ2
26.67Single7XK9Constrained Isoproterenol7XK9-β2-Constrained Isoproterenol-Na
26.67Single7XKAConstrained Epinephrine7XKA-β2-Constrained Epinephrine
26.67Single8EFBOliceridine8EFB-μ-Oliceridine-Gi1/β1/γ2
26.67Single8FYNZM-2413858FYN-A2A-ZM-241385-Na
26.67Single8GDZConstrained Epinephrine8GDZ-β2-Constrained Epinephrine-Gs/β1/γ2
26.67Single8GEBConstrained Epinephrine8GEB-β2-Constrained Epinephrine-Gs/β1/γ2
26.67Single8GEGConstrained Epinephrine8GEG-β2-Constrained Epinephrine-Gs/β1/γ2
26.67Single8GFYConstrained Epinephrine8GFY-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
26.67Single8GG2Constrained Epinephrine8GG2-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
26.67Single8GGBConstrained Epinephrine8GGB-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
26.67Single8GNEKW-63568GNE-A2A-KW-6356-Na
26.67Single8HNLPS3724248HNL-CXCR3-PS372424-Gi1/β1/γ2
26.67Single8ID4Linoleic acid8ID4-FFA4-Linoleic acid-Gi1/β1/γ2
26.67Single8J6JGSK2560738J6J-HCA2-GSK256073-Gi1/β1/γ2
26.67Single8QOTNanobody-E8QOT-μ-Nanobody-E
26.67Single8UNNConstrained Epinephrine8UNN-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
26.67Single8UNPConstrained Epinephrine8UNP-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
26.67Single9F34FOB02-04A9F34-D3-FOB02-04A-Go1/β1/γ2
26.67Single9MQKIsoquinuclidine9MQK-κ-Isoquinuclidine
26.67Consensus5ht5_on_gpOrthosteric Ligand5ht5a_on_gp
26.67Consensus5ht5a_on_gpOrthosteric Ligand7X5H-5-HT5A-5-CT-Gi1/β1/γ2 7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/β1/γ2 7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/β1/γ2
26.67Consensusa3_on_gpOrthosteric Liganda3a_on_gp
26.67Consensusa3a_onOrthosteric Ligand8X17-A3A-Namodenoson-Gi1/β1/γ2 8X16-A3A-Piclidenoson-Gi1/β1/γ2
26.67Consensusa3a_on_gpOrthosteric Ligand8X17-A3A-Namodenoson-Gi1/β1/γ2 8X16-A3A-Piclidenoson-Gi1/β1/γ2
26.67Consensusadrenergic_offOrthosteric Ligandalpha_off beta_off
26.67Consensusadrenergic_on_gpOrthosteric Ligandalpha_on_gp beta_on_gp
26.67Consensusalpha2c_offOrthosteric Ligand6KUW-α2c-PubChem 57213234
26.67Consensusalpha_offOrthosteric Ligandalpha1_off alpha2_off
26.67Consensusalpha_on_gpOrthosteric Ligandalpha1_on_gp alpha2_on_gp
26.67Consensusbb2_offOrthosteric Ligand7W41-BB2-PD176252
26.67Consensusblt1_offOrthosteric Ligand5X33-BLT1-BIIL260 7K15-BLT1-MKD046-Na
26.67Consensusblt_offOrthosteric Ligandblt1_off
26.67Consensusbombesin_offOrthosteric Ligandbb2_off
26.67Consensusd2_onOrthosteric Ligand7JVR-D2-Bromoergocryptine-Gi1/β1/γ2 8IRS-D2-Rotigotine-Gi1/β1/γ2
26.67Consensusgs_amineOrthosteric Ligandgs_5ht gs_adrenergic gs_dopamine gs_histamine gs_trace-amine
26.67Consensusm2_offOrthosteric Ligand5ZKC-M2-N-Methyl-Scopolamine 5ZK3-M2-3-quinuclidinyl-benzilate 5ZKB-M2-AF-DX 384
26.67Consensusm3_onOrthosteric Ligand8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/β1/γ2 8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/β1/γ2 8E9Y-M3-Clozapine-N-oxide-chim(NtGi2L-Gs-CtGq)/β1/γ2
26.67Consensusm3_on_gpOrthosteric Ligand8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/β1/γ2 8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/β1/γ2 8E9Y-M3-Clozapine-N-oxide-chim(NtGi2L-Gs-CtGq)/β1/γ2
26.32Single4AMJS-Carvedilol4AMJ-β1-S-Carvedilol
26.32Single7WICSomatostatin-147WIC-SST2-Somatostatin-14-Gi1/β1/γ2
26.32Single7WVWfMYFINILTL7WVW-FPR2-ALX-fMYFINILTL-Gi2/β1/γ2
26.32Single8FYLVilazodone8FYL-5-HT1A-Vilazodone-Gi1/β1/γ1
26.32Single8PKMBefiradol8PKM-5-HT1A-Befiradol-t7m-Gi1/β1/γ1
26.32Single8WDTphotoNECA8WDT-A2A-photoNECA
26.32Single8ZSPLSD8ZSP-TA1-LSD-chim(NtGi1L-Gs-CtGq)/β1/γ2
25.00Single3UON3-quinuclidinyl-benzilate3UON-M2-3-quinuclidinyl-benzilate
25.00Single3VGAZM-2413853VGA-A2A-ZM-241385-Antibody
25.00Single4LDLHydroxybenzylisoproterenol4LDL-β2-Hydroxybenzylisoproterenol
25.00Single4OO9Mavoglurant4OO9-mGlu5-Mavoglurant
25.00Single4U15Tiotropium4U15-M3-Tiotropium
25.00Single6E59L-7607356E59-NK1-L-760735
25.00Single6H7JIsoprenaline6H7J-β1-Isoprenaline
25.00Single6I9K9-cis-Retinal6I9K-Rhodopsin-9-cis-Retinal
25.00Single6KO5PubChem 574000026KO5-Ghrelin-PubChem 57400002
25.00Single6N48BI1671076N48-β2-BI167107-PubChem 138454256
25.00Single6OL9Tiotropium6OL9-M5-Tiotropium
25.00Single6QNOAll-trans-Retinal6QNO-Rhodopsin-All-trans-Retinal-Gi1/β1/γ1
25.00Single6TQ7SB-3348676TQ7-OX1-SB-334867
25.00Single7CUMPhospholipid7CUM-GABAB1, GABAB2-CGP54626-Phospholipid
25.00Single7D76Beclomethasone7D76-ADGRG3-Beclomethasone-Go/β1/γ2
25.00Single7DFLHistamine7DFL-H1-Histamine-chim(NtGi1L-Gq)/β1/γ2
25.00Single7E2YSerotonin7E2Y-5-HT1A-Serotonin-Gi1/β1/γ2
25.00Single7EW4CYM55417EW4-S1P3-CYM5541-Gi1/β1/γ2
25.00Single7EW7SEW28717EW7-S1P1-SEW2871-Gi1/β1/γ2
25.00Single7JJOIsoprenaline7JJO-β1-Isoprenaline-Gs/β1/γ2
25.00Single7PX4PSB-21137PX4-A2A-PSB-2113
25.00Single7T2HLofentanil7T2H-μ-Lofentanil-Gi1/β1/γ2
25.00Single7TRQIperoxo7TRQ-M4-Iperoxo-VU0467154-Gi1/β1/γ2
25.00Single7TUYGSK682753A7TUY-GPR183-GSK682753A
25.00Single7U2LPubChem 1632012427U2L-μ-PubChem 163201242-Gi1/β1/γ2
25.00Single7XT9Serotonin7XT9-5-HT4-Serotonin-Gs/β1/γ2
25.00Single7Y24Octreotide7Y24-SST2-Octreotide-Go/β1/γ2
25.00Single7YFCHistamine7YFC-H4-Histamine-chim(NtGi1-Gs-CtGq)/β1/γ2
25.00Single7YFDImetit7YFD-H4-Imetit-chim(NtGi1-Gs-CtGq)/β1/γ2
25.00Single7YS6Serotonin7YS6-5-HT6-Serotonin-chim(NtGi1-Gs)/β1/γ2
25.00Single8A2PLUAA470708A2P-A2A-LUAA47070-Na
25.00Single8DZPmomSalB8DZP-κ-momSalB-Gi1/β1/γ2
25.00Single8EF5Fentanyl8EF5-μ-Fentanyl-Gi1/β1/γ2
25.00Single8GGYConstrained Epinephrine8GGY-β2-Constrained Epinephrine
25.00Single8H2GNiacin8H2G-HCA2-Niacin-Gi1/β1/γ2
25.00Single8HN8Histamine8HN8-H4-Histamine-Gi1/β1/γ2
25.00Single8ID39-Hydroxystearic acid8ID3-FFA4-9-Hydroxystearic acid-Gi1/β1/γ2
25.00Single8IRVRotigotine8IRV-D5-Rotigotine-chim(NtGi1-Gs)/β1/γ2
25.00Single8IYHMK68928IYH-HCA2-MK6892-Go/β1/γ2
25.00Single8JD5BQI; HZE; PEF8JD5-mGlu2; mGlu4-Glutamate-BQI; HZE; PEF-Gi1/β1/γ2
25.00Single8JLOUlotaront8JLO-TA1-Ulotaront-Gs/β1/γ2
25.00Single8JT6(R)-IHCH-71798JT6-5-HT1A-(R)-IHCH-7179-Gi1/β1/γ2
25.00Single8K5BNiacin8K5B-HCA2-Niacin
25.00Single8RWHStilSwitch28RWH-A2A-StilSwitch2-Na
25.00Single8TAOCDPPB8TAO-mGlu5; mGlu5-Quisqualate-CDPPB
25.00Single8UGWPubChem 30865998UGW-A2A-PubChem 3086599
25.00Single8UO3Constrained Epinephrine8UO3-β2-Constrained Epinephrine-GTP; Mg-Gs/β1/γ2
25.00Single8UO4Constrained Epinephrine8UO4-β2-Constrained Epinephrine-GTP; Mg-Gs/β1/γ2
25.00Single8VVFJDTic8VVF-κ-JDTic-Gi1/β1/γ2
25.00Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/β1/γ2
25.00Single8X16Piclidenoson8X16-A3A-Piclidenoson-Gi1/β1/γ2
25.00Single8XJMLatanoprost8XJM-FP-alpha-Latanoprost-chim(NtGi2-Gs-CtGq)/β1/γ2
25.00Single8XVLZibotentan8XVL-ETA-Zibotentan
25.00Single8XZICMF-0198XZI-Apelin-CMF-019-Gi1/β1/γ2
25.00Single8YN4Histamine8YN4-H2-Histamine-chim(NtGi1L-Gs-CtGq)/β1/γ2
25.00Single8YN5Histamine8YN5-H3-Histamine-Gi1/β1/γ2
25.00Single8YN6Imetit8YN6-H3-Imetit-Gi1/β1/γ2
25.00Single8YN7Immethridine8YN7-H3-Immethridine-Go1/β1/γ2
25.00Single8YNTSNAP-948478YNT-MCH1-SNAP-94847
25.00Single8YUVImmepip8YUV-H3-Immepip-Gi1/β1/γ2
25.00Single8ZR5Firuglipel8ZR5-GPR119-Firuglipel-Gs/β1/γ2
25.00Single8ZSVRO52633978ZSV-TA1-RO5263397-chim(NtGi1-Gs)/β1/γ2
25.00Single9EPQ11,20-Ethanoretinal9EPQ-Rhodopsin-11,20-Ethanoretinal-chim(Gi1-CtGq)/β1/γ2
25.00Single9IJDCarazolol9IJD-β3-Carazolol-chim(NtGi1-Gs)/β1/γ2
25.00Single9IQTNiacin9IQT-HCA2-Niacin-Gi1/β1/γ2
25.00Consensusbeta2_onOrthosteric Ligand7DHI-β2-Salbutamol-Gs/β1/γ2 6NI3-β2-BI167107-Gs/β1/γ2
25.00Consensusbeta2_on_gpOrthosteric Ligand7DHI-β2-Salbutamol-Gs/β1/γ2 6NI3-β2-BI167107-Gs/β1/γ2
25.00Consensusd1_on_gpOrthosteric Ligand7F0T-D1-Dopamine-Gs/β1/γ2 7CKY-D1-PW0464-Gs/β1/γ2 8IRR-D1-Rotigotine-Gs/β1/γ2 7JV5-D1-SKF81297-Gs/β1/γ2 7JVP-D1-SKF83959-Gs/β1/γ2 7X2D-D1-Tavapadon-Gs/β1/γ2 7CKX-D1-A77636-Gs/β1/γ2 7JVQ-D1-Apomorphine-Gs/β1/γ2 7CKW-D1-Fenoldopam-Gs/β1/γ2
25.00Consensusd5_on_gpOrthosteric Ligand8IRV-D5-Rotigotine-chim(NtGi1-Gs)/β1/γ2
25.00Consensusgi_5htOrthosteric Ligand8FYT-5-HT1A-LSD-Gi1/β1/γ1 7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/β1/γ2 8UGY-5-HT1E-Mianserin-Gi1/β1/γ1 8W8B-5-HT1A-SEP-363856-Gi1/β1/γ2 7E2Y-5-HT1A-Serotonin-Gi1/β1/γ2 7E32-5-HT1D-Serotonin-Gi1/β1/γ2 7XTA-5-HT4-Serotonin-Gi1/β1/γ2 8UH3-5-HT1E-Setiptiline-Gi1/β1/γ1 8JSP-5-HT1A-Ulotaront-Gi1/β1/γ2 8FYL-5-HT1A-Vilazodone-Gi1/β1/γ1 8JT6-5-HT1A-(R)-IHCH-7179-Gi1/β1/γ2 8FYE-5-HT1A-4-F,5-MeO-PyrT-Gi1/β1/γ1 7X5H-5-HT5A-5-CT-Gi1/β1/γ2 8FY8-5-HT1A-5-MeO-DMT-Gi1/β1/γ1 7E2Z-5-HT1A-Aripiprazole-Gi1/β1/γ2 7E33-5-HT1E-BRL-54443-Gi1/β1/γ2 8FYX-5-HT1A-Buspirone-Gi1/β1/γ1 7EXD-5-HT1F-Lasmiditan-Gi1/β1/γ2 7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/β1/γ2
25.00Consensusgi_dopamineOrthosteric Ligand7JVR-D2-Bromoergocryptine-Gi1/β1/γ2 7CMV-D3-PD128907-Gi1/β1/γ2 7CMU-D3-Pramipexole-Gi1/β1/γ2 8IRS-D2-Rotigotine-Gi1/β1/γ2 8IRT-D3-Rotigotine-Gi1/β1/γ2
25.00Consensusgq_class-aOrthosteric Ligandgq_peptide gq_amine gq_nucleotide
25.00Consensusgs_adrenergicOrthosteric Ligand7DHI-β2-Salbutamol-Gs/β1/γ2 7XJI-β3-Solabegron-Gs/β1/γ2 7JJO-β1-Isoprenaline-Gs/β1/γ2 6NI3-β2-BI167107-Gs/β1/γ2 8DCR-β1-Dobutamine-Gs/β1/γ2 7XJH-β3-Isoproterenol-Gs/β1/γ2 7DH5-β3-Mirabegron-Gs/β1/γ2
25.00Consensusgs_dopamineOrthosteric Ligand7F0T-D1-Dopamine-Gs/β1/γ2 7CKW-D1-Fenoldopam-Gs/β1/γ2 7CKY-D1-PW0464-Gs/β1/γ2 8IRV-D5-Rotigotine-chim(NtGi1-Gs)/β1/γ2 8IRR-D1-Rotigotine-Gs/β1/γ2 7JV5-D1-SKF81297-Gs/β1/γ2 7JVP-D1-SKF83959-Gs/β1/γ2 7X2D-D1-Tavapadon-Gs/β1/γ2 7CKX-D1-A77636-Gs/β1/γ2 7JVQ-D1-Apomorphine-Gs/β1/γ2
25.00Consensush1_onOrthosteric Ligand7DFL-H1-Histamine-chim(NtGi1L-Gq)/β1/γ2
25.00Consensush4_onOrthosteric Ligand8HN8-H4-Histamine-Gi1/β1/γ2 8HOC-H4-Imetit-Gi1/β1/γ2 8JXV-H4-Clozapine-Gi1/β1/γ2 8JXW-H4-VUF6884-Gi1/β1/γ2 8JXX-H4-Clobenpropit-Gi1/β1/γ2
25.00Consensush4_on_gpOrthosteric Ligand8HN8-H4-Histamine-Gi1/β1/γ2 8HOC-H4-Imetit-Gi1/β1/γ2 8JXV-H4-Clozapine-Gi1/β1/γ2 8JXW-H4-VUF6884-Gi1/β1/γ2 8JXX-H4-Clobenpropit-Gi1/β1/γ2
25.00Consensusm5_offOrthosteric Ligand6OL9-M5-Tiotropium
25.00Consensusmuscarinic_offOrthosteric Ligandm2_off m3_off m4_off m5_off m1_off
25.00Consensussst4_onOrthosteric Ligand7XMS-SST4-Somatostatin-14-Gi1/β1/γ2 7XMT-SST4-J-2156-Gi1/β1/γ2
25.00Consensussst4_on_gpOrthosteric Ligand7XMS-SST4-Somatostatin-14-Gi1/β1/γ2 7XMT-SST4-J-2156-Gi1/β1/γ2
23.81Single5WF5UK-4320975WF5-A2A-UK-432097
23.81Single6PT2KGCHM076PT2-δ-KGCHM07
23.81Single7T6TfMLFII7T6T-FPR1-ALX-fMLFII-Gi1/β1/γ2
23.81Single8XIQL7967788XIQ-SST3-L796778-chim(NtGi1-Gs-CtGi1)/β1/γ2
23.81Consensusgi_somatostatinOrthosteric Ligand7WIC-SST2-Somatostatin-14-Gi1/β1/γ2 7XMS-SST4-Somatostatin-14-Gi1/β1/γ2 8X8L-SST5-Cortistatin-chim(NtGi1-Gs-CtGi1)/β1/γ2 7XMT-SST4-J-2156-Gi1/β1/γ2 7WIG-SST2-L-054,264-Gi1/β1/γ2 8X8N-SST5-Octreotide-chim(NtGi1-Gs-CtGi1)/β1/γ2 7YAE-SST2-Octreotide-Gi1/β1/γ2 7YAC-SST2-Paltusotine-Gi1/β1/γ2
23.81Consensussomatostatin_onOrthosteric Ligandsst2_on sst4_on sst5_on
23.81Consensussomatostatin_on_gpOrthosteric Ligandsst2_on_gp sst4_on_gp sst5_on_gp
23.53Single4LDEBI1671074LDE-β2-BI167107
23.53Single4RWADIPP-NH24RWA-δ-DIPP-NH2
23.53Single5CXVTiotropium5CXV-M1-Tiotropium
23.53Single5UNHPubChem 1264564065UNH-AT2-PubChem 126456406
23.53Single6A93Risperidone6A93-5-HT2A-Risperidone
23.53Single6DRYMethylergonovine6DRY-5-HT2B-Methylergonovine
23.53Single6VMSBromoergocryptine6VMS-D2-Bromoergocryptine-Gi1/β1/γ2
23.53Single6XBLCholesterol6XBL-SMO-SAG-Cholesterol-Gi1/β1/γ2
23.53Single6ZG4HTL00099366ZG4-M1-HTL0009936
23.53Single7EVYSiponimod7EVY-S1P1-Siponimod-Gi1/β1/γ2
23.53Single7JNIOlodanrigan7JNI-AT2-Olodanrigan
23.53Single7W0LPubChem 1227019087W0L-Apelin-PubChem 122701908-Gi1/β1/γ2
23.53Single7W0LPubChem 1227019087W0L-Apelin-PubChem 122701908-Gi1/β1/γ2
23.53Single7WCMMBX-29827WCM-GPR119-MBX-2982-Gs/β1/γ2
23.53Single7XW9TRH7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/β1/γ2
23.53Single7XZ5Lysophosphatidylcholine7XZ5-GPR119-Lysophosphatidylcholine-Gs/β1/γ2
23.53Single8E9W2-Deoxycytidine8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/β1/γ2
23.53Single8G056-OAU8G05-GPR84-6-OAU-Gi1/β1/γ2
23.53Single8IQ6Latanoprost8IQ6-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/β1/γ2
23.53Single8IRSRotigotine8IRS-D2-Rotigotine-Gi1/β1/γ2
23.53Single8JJ8Formoterol8JJ8-β2-Formoterol
23.53Single8JJPChemerin8JJP-CML2-Chemerin-Gi1/β1/γ2
23.53Single8JWY2-1188JWY-A2A-2-118
23.53Single8JWZAB9288JWZ-A2A-AB928-Na
23.53Single8JZ7MK68928JZ7-HCA2-MK6892-Gi1/β1/γ2
23.53Single9MQLIsoquinuclidine9MQL-κ-Isoquinuclidine
23.53Consensus5ht1a_onOrthosteric Ligand8FYT-5-HT1A-LSD-Gi1/β1/γ1 7E2Y-5-HT1A-Serotonin-Gi1/β1/γ2 7E2Z-5-HT1A-Aripiprazole-Gi1/β1/γ2 8FYX-5-HT1A-Buspirone-Gi1/β1/γ1 8JSP-5-HT1A-Ulotaront-Gi1/β1/γ2 8JT6-5-HT1A-(R)-IHCH-7179-Gi1/β1/γ2 8FY8-5-HT1A-5-MeO-DMT-Gi1/β1/γ1 8FYE-5-HT1A-4-F,5-MeO-PyrT-Gi1/β1/γ1 8FYL-5-HT1A-Vilazodone-Gi1/β1/γ1
23.53Consensus5ht1a_on_gpOrthosteric Ligand8FYT-5-HT1A-LSD-Gi1/β1/γ1 8FYX-5-HT1A-Buspirone-Gi1/β1/γ1 8JSP-5-HT1A-Ulotaront-Gi1/β1/γ2 8JT6-5-HT1A-(R)-IHCH-7179-Gi1/β1/γ2 7E2Y-5-HT1A-Serotonin-Gi1/β1/γ2 7E2Z-5-HT1A-Aripiprazole-Gi1/β1/γ2 8FY8-5-HT1A-5-MeO-DMT-Gi1/β1/γ1 8FYE-5-HT1A-4-F,5-MeO-PyrT-Gi1/β1/γ1 8FYL-5-HT1A-Vilazodone-Gi1/β1/γ1
23.53Consensusbeta3_onOrthosteric Ligand7DH5-β3-Mirabegron-Gs/β1/γ2 7XJH-β3-Isoproterenol-Gs/β1/γ2 7XJI-β3-Solabegron-Gs/β1/γ2
23.53Consensusbeta3_on_gpOrthosteric Ligand7DH5-β3-Mirabegron-Gs/β1/γ2 7XJH-β3-Isoproterenol-Gs/β1/γ2 7XJI-β3-Solabegron-Gs/β1/γ2
23.53Consensusbeta_onOrthosteric Ligandbeta1_on beta2_on beta3_on
23.53Consensusbeta_on_gpOrthosteric Ligandbeta1_on_gp beta2_on_gp beta3_on_gp
23.53Consensusd2_on_gpOrthosteric Ligand7JVR-D2-Bromoergocryptine-Gi1/β1/γ2 8IRS-D2-Rotigotine-Gi1/β1/γ2
23.53Consensusgi_amineOrthosteric Ligandgi_5ht gi_muscarinic gi_adrenergic gi_dopamine gi_histamine
23.53Consensusgi_muscarinicOrthosteric Ligand8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/β1/γ2 7T8X-M2-Acetylcholine-chim(NtGi1-Go)/β1/γ2 7TRS-M4-Acetylcholine-Gi1/β1/γ2 7TRK-M4-Iperoxo-Gi1/β1/γ2 7V6A-M4-PubChem 9864275-Gi1/β1/γ2
23.53Consensusm1_offOrthosteric Ligand5CXV-M1-Tiotropium
23.53Consensusmop_onOrthosteric Ligand8F7R-μ-Endomorphin-Gi1/β1/γ2 8EF5-μ-Fentanyl-Gi1/β1/γ2 7SCG-μ-FH210-Gi1/β1/γ2 7T2H-μ-Lofentanil-Gi1/β1/γ2 7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2 8EF6-μ-Morphine-Gi1/β1/γ2 8EFB-μ-Oliceridine-Gi1/β1/γ2 7U2L-μ-PubChem 163201242-Gi1/β1/γ2 8EFO-μ-PZM21-Gi1/β1/γ2 8EFL-μ-SR17018-Gi1/β1/γ2 8F7Q-μ-β-Endorphin-Gi1/β1/γ2 7U2K-μ-C6-guano-Gi1/β1/γ2 8EFQ-μ-Damgo-Gi1/β1/γ2
23.53Consensusmop_on_gpOrthosteric Ligand8F7R-μ-Endomorphin-Gi1/β1/γ2 8EF5-μ-Fentanyl-Gi1/β1/γ2 7SCG-μ-FH210-Gi1/β1/γ2 7T2H-μ-Lofentanil-Gi1/β1/γ2 7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2 8EF6-μ-Morphine-Gi1/β1/γ2 8EFB-μ-Oliceridine-Gi1/β1/γ2 7U2L-μ-PubChem 163201242-Gi1/β1/γ2 8EFO-μ-PZM21-Gi1/β1/γ2 8EFL-μ-SR17018-Gi1/β1/γ2 8F7Q-μ-β-Endorphin-Gi1/β1/γ2 7U2K-μ-C6-guano-Gi1/β1/γ2 8EFQ-μ-Damgo-Gi1/β1/γ2
23.53Consensuss1p1_onOrthosteric Ligand7VIE-S1P1-S1P-Gi1/β1/γ2 7VIF-S1P1-S-FTY720-P-Gi1/β1/γ2 7VIG-S1P1-CBP-307-Gi1/β1/γ2 7EVY-S1P1-Siponimod-Gi1/β1/γ2 7EVZ-S1P1-Cenerimod-Gi1/β1/γ2 7EW0-S1P1-Ozanimod-Gi1/β1/γ2 7EW7-S1P1-SEW2871-Gi1/β1/γ2
23.53Consensuss1p1_on_gpOrthosteric Ligand7VIE-S1P1-S1P-Gi1/β1/γ2 7VIF-S1P1-S-FTY720-P-Gi1/β1/γ2 7VIG-S1P1-CBP-307-Gi1/β1/γ2 7EVY-S1P1-Siponimod-Gi1/β1/γ2 7EVZ-S1P1-Cenerimod-Gi1/β1/γ2 7EW0-S1P1-Ozanimod-Gi1/β1/γ2 7EW7-S1P1-SEW2871-Gi1/β1/γ2
23.53Consensustrh_onOrthosteric Ligand7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/β1/γ2
23.53Consensustrh_on_gpOrthosteric Ligand7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/β1/γ2
23.08Single2X72All-trans-Retinal2X72-Rhodopsin-All-trans-Retinal-Gt(CT)
23.08Single3PWHZM-2413853PWH-A2A-ZM-241385
23.08Single3VG9ZM-2413853VG9-A2A-ZM-241385-Antibody
23.08Single4S0VSuvorexant4S0V-OX2-Suvorexant
23.08Single5K2DZM-2413855K2D-A2A-ZM-241385-Na
23.08Single5OLHVipadenant5OLH-A2A-Vipadenant-Na
23.08Single5OLVLUAA410635OLV-A2A-LUAA41063-Na
23.08Single5WS3EMPA5WS3-OX2-EMPA
23.08Single6B73MP11046B73-κ-MP1104
23.08Single6FKBPubChem 1324730386FKB-Rhodopsin-PubChem 132473038
23.08Single6JZHZM-2413856JZH-A2A-ZM-241385-Na
23.08Single6NWEOctyl-Beta-D-Glucopyranoside6NWE-Rhodopsin-Octyl-β-D-Glucopyranoside-Gt(CT)
23.08Single6OBAS-Alprenolol6OBA-β2-S-Alprenolol-GTPL11074
23.08Single6PS7ZM-2413856PS7-A2A-ZM-241385-Na
23.08Single6TODEMPA6TOD-OX1-EMPA-Na
23.08Single6TPJSuvorexant6TPJ-OX2-Suvorexant
23.08Single7DHRIsoprenaline7DHR-β2-Isoprenaline-Gs/β1/γ2
23.08Single7LJDDopamine7LJD-D1-Dopamine-Mevidalen-Gs/β1/γ1
23.08Single7M3ECa; Ca; Tryptophan; NPS-21437M3E-CaS-Ca; Ca; Tryptophan; NPS-2143
23.08Single7M3ECa; Ca; Tryptophan; NPS-21437M3E-CaS-Ca; Ca; Tryptophan; NPS-2143
23.08Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
23.08Single7X5H5-CT7X5H-5-HT5A-5-CT-Gi1/β1/γ2
23.08Single7XT8Serotonin7XT8-5-HT4-Serotonin-Gs/β1/γ2
23.08Single8FYXBuspirone8FYX-5-HT1A-Buspirone-Gi1/β1/γ1
23.08Single8GNGIstradefylline8GNG-A2A-Istradefylline
23.08Single8IJANiacin8IJA-HCA2-Niacin-Gi1/β1/γ2
23.08Single8IJBAcipimox8IJB-HCA2-Acipimox-Gi1/β1/γ2
23.08Single8RVWStilSwitch38RVW-A2A-StilSwitch3-Na
23.08Single8RW0Istradefylline8RW0-A2A-Istradefylline-Na
23.08Single8RW4AzoSwitch28RW4-A2A-AzoSwitch2-Na
23.08Single8RWEStilSwitch48RWE-A2A-StilSwitch4-Na
23.08Single8SZGCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-chim(NtGi1-Gq)/β1/γ2
23.08Single8TZQL-Dopamine8TZQ-D2-L-Dopamine-Go/β1/γ2
23.08Single8UNSConstrained Epinephrine8UNS-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
23.08Single8UNTConstrained Epinephrine8UNT-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
23.08Single8WC4ZH86518WC4-TA1-ZH8651-chim(NtGi1-Gs)/β1/γ2
23.08Single8WCA2-Phenylethylamine8WCA-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/β1/γ2
23.08Single8WOGSuccinic acid8WOG-Succinate-Succinic acid-Gi1/β1/γ2
23.08Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
23.08Single8YKXMaleic acid8YKX-Succinate-Maleic acid-Gi1/β1/γ1
23.08Single9AVLCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVL-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi3/β2/γ2
23.08Single9FUPIstradefylline9FUP-A2A-Istradefylline-Na
23.08Consensus5ht_onOrthosteric Ligand5ht1_on 5ht2_on 5ht4_on 5ht5_on 5ht6_on 5ht7_on
23.08Consensusangiotensin_offOrthosteric Ligandat1_off
23.08Consensusgi_succinateOrthosteric Ligand8YKW-Succinate-Succinic acid-Gi1/β1/γ1 8YKX-Succinate-Maleic acid-Gi1/β1/γ1
23.08Consensusgq_histamineOrthosteric Ligand7DFL-H1-Histamine-chim(NtGi1L-Gq)/β1/γ2
23.08Consensusgs_5htOrthosteric Ligand7XTC-5-HT7-5-CT-Gs/β1/γ2 7XTB-5-HT6-Serotonin-Gs/β1/γ2 8JLZ-5-HT6-ST1936-Gs/β1/γ2 7XT8-5-HT4-Serotonin-Gs/β1/γ2
23.08Consensush1_on_gpOrthosteric Ligand7DFL-H1-Histamine-chim(NtGi1L-Gq)/β1/γ2
23.08Consensushistamine_onOrthosteric Ligandh1_on h2_on h3_on h4_on
23.08Consensushistamine_on_gpOrthosteric Ligandh1_on_gp h2_on_gp h3_on_gp h4_on_gp
23.08Consensusox1_offOrthosteric Ligand6TP6-OX1-Filorexant 6TP4-OX1-ACT-462206 6V9S-OX1-GTPL11403 6TOT-OX1-Lemborexant 6TP3-OX1-Nemorexant 6TQ6-OX1-PubChem 145714283 6TQ9-OX1-SB-408124 4ZJC-OX1-SB-674042 4ZJ8-OX1-Suvorexant 6TOD-OX1-EMPA-Na 6TOS-OX1-GSK1059865-Na 6TQ4-OX1-PubChem 16046844-Na
23.08Consensussuccinate_onOrthosteric Ligand8YKW-Succinate-Succinic acid-Gi1/β1/γ1 8YKX-Succinate-Maleic acid-Gi1/β1/γ1
23.08Consensussuccinate_on_gpOrthosteric Ligand8YKW-Succinate-Succinic acid-Gi1/β1/γ1 8YKX-Succinate-Maleic acid-Gi1/β1/γ1
22.73Single7WUIIP157WUI-ADGRG2-IP15-chim(NtGi1-Gs)/β1/γ2
22.73Single8IEDA1LYA8IED-GPR156-A1LYA-Go/β1/γ2
22.73Single8X8LCortistatin8X8L-SST5-Cortistatin-chim(NtGi1-Gs-CtGi1)/β1/γ2
22.73Consensuscxcr3_on_gpOrthosteric Ligand8HNK-CXCR3-CXCL11-Gi1/β1/γ2 8HNL-CXCR3-PS372424-Gi1/β1/γ2
22.22Single4NC3Ergotamine4NC3-5-HT2B-Ergotamine
22.22Single5CGDHTL142425CGD-mGlu5-HTL14242
22.22Single5MZPCaffeine5MZP-A2A-Caffeine-Na
22.22Single5UNGPubChem 157800525UNG-AT2-PubChem 15780052
22.22Single5X93K-87945X93-ETB-K-8794
22.22Single6H7LDobutamine6H7L-β1-Dobutamine
22.22Single6IBLArformoterol6IBL-β1-Arformoterol
22.22Single6TKOArformoterol6TKO-β1-Arformoterol-Arrestin2
22.22Single7EVZCenerimod7EVZ-S1P1-Cenerimod-Gi1/β1/γ2
22.22Single7EW0Ozanimod7EW0-S1P1-Ozanimod-Gi1/β1/γ2
22.22Single7EZCUKA7EZC-A2A-UKA
22.22Single7SK7CCX6627SK7-ACKR3-CXCL12-CCX662
22.22Single7SK8CCX6627SK8-ACKR3-CXCL12-CCX662
22.22Single7U2KC6-guano7U2K-μ-C6-guano-Gi1/β1/γ2
22.22Single7UM4AS26747237UM4-5-HT5A-AS2674723
22.22Single7VGY2-Iodomelatonin7VGY-MT1-2-Iodomelatonin-Gi1/β1/γ2
22.22Single7WVVfMLFII7WVV-FPR2-ALX-fMLFII-Gi2/β1/γ2
22.22Single7X1UTRH7X1U-TRH-TRH-chim(NtGi2L-Gs-CtGq)/β1/γ2
22.22Single7XK2MK68927XK2-HCA2-MK6892-Gi1/β1/γ2
22.22Single8E9X2-Deoxycytidine8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/β1/γ2
22.22Single8FX5Xanomeline8FX5-M4-Xanomeline-Xanomeline-Gi1/β1/γ2
22.22Single8GEJConstrained Epinephrine8GEJ-β2-Constrained Epinephrine-Gs/β1/γ2
22.22Single8IJDMK68928IJD-HCA2-MK6892-Gi1/β1/γ2
22.22Single8IULLatanoprost8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/β1/γ2
22.22Single8IYSTUG-8918IYS-FFA4-TUG-891-GDP-chim(NtGi1L-Gq)/β1/γ2
22.22Single8K2XCXCL108K2X-CXCR3-CXCL10-Gi1/β1/γ2
22.22Single8WCBCyclohexylammonium Ion8WCB-TA1-Cyclohexylammonium Ion-chim(NtGi1-Gs-CtGq)/β1/γ2
22.22Single8WCCCyclohexylammonium Ion8WCC-TA1-Cyclohexylammonium Ion
22.22Single8XJKCloprosetnol8XJK-FP-alpha-Cloprosetnol-chim(NtGi1-Gs-CtGq)/β1/γ2
22.22Single8XOFLys058XOF-GPR30-Lys05-chim(NtGi1-Gs-CtGq)/β1/γ2
22.22Consensusbeta1_onOrthosteric Ligand8DCR-β1-Dobutamine-Gs/β1/γ2 7S0F-β1-Isoprenaline-Gi1/β1/γ2
22.22Consensusbeta1_on_gpOrthosteric Ligand8DCR-β1-Dobutamine-Gs/β1/γ2 7S0F-β1-Isoprenaline-Gi1/β1/γ2
22.22Consensusclass-a_onOrthosteric Ligandsensory_on alicarboxylic_on amine_on lipid_on nucleotide_on peptide_on protein_on
22.22Consensusendothelin_offOrthosteric Ligandetb_off
22.22Consensusetb_offOrthosteric Ligand5X93-ETB-K-8794 5XPR-ETB-Bosentan 6K1Q-ETB-IRL2500
22.22Consensusgi_s1pOrthosteric Ligand7VIE-S1P1-S1P-Gi1/β1/γ2 7EW3-S1P3-S1P-Gi1/β1/γ2 7EVY-S1P1-Siponimod-Gi1/β1/γ2 7EW1-S1P5-Siponimod-Gi1/β1/γ2 7VIF-S1P1-S-FTY720-P-Gi1/β1/γ2 7VIG-S1P1-CBP-307-Gi1/β1/γ2 7EVZ-S1P1-Cenerimod-Gi1/β1/γ2 7EW4-S1P3-CYM5541-Gi1/β1/γ2 7EW2-S1P3-Fingolimod-Gi1/β1/γ2 7EW0-S1P1-Ozanimod-Gi1/β1/γ2 7EW7-S1P1-SEW2871-Gi1/β1/γ2
22.22Consensusnucleotide_on_gpOrthosteric Ligandadenosine_on_gp p2y_on_gp
22.22Consensuspeptide_offOrthosteric Ligandcck_off angiotensin_off bombesin_off endothelin_off ghrelin_off npy_off opioid_off orexin_off somatostatin_off tachykinin_off vasop-oxy_off neurotensin_off
22.22Consensusprostanoid_offOrthosteric Ligandep_off dp_off
21.74Single8HNKCXCL118HNK-CXCR3-CXCL11-Gi1/β1/γ2
21.74Consensussst5_on_gpOrthosteric Ligand8X8L-SST5-Cortistatin-chim(NtGi1-Gs-CtGi1)/β1/γ2 8X8N-SST5-Octreotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
21.43Single3REYXAC3REY-A2A-XAC
21.43Single3RZECidoxepin3RZE-H1-Cidoxepin
21.43Single4MQTIperoxo4MQT-M2-Iperoxo-LY2119620
21.43Single4ZJCSB-6740424ZJC-OX1-SB-674042
21.43Single4ZUDOlmesartan4ZUD-AT1-Olmesartan
21.43Single5IU4ZM-2413855IU4-A2A-ZM-241385-Na
21.43Single5IUBQ274563445IUB-A2A-Q27456344-Na
21.43Single5K2BZM-2413855K2B-A2A-ZM-241385-Na
21.43Single5K2CZM-2413855K2C-A2A-ZM-241385-Na
21.43Single5NLXZM-2413855NLX-A2A-ZM-241385-Na
21.43Single5NM4ZM-2413855NM4-A2A-ZM-241385-Na
21.43Single6FFIMMPEP6FFI-mGlu5-MMPEP
21.43Single6FK8PubChem 1324730356FK8-Rhodopsin-PubChem 132473035
21.43Single6FKAPubChem 1324730376FKA-Rhodopsin-PubChem 132473037
21.43Single6IQLL7458706IQL-D4-L745870
21.43Single6ME32-Phenylmelatonin6ME3-MT1-2-Phenylmelatonin
21.43Single6ME42-Iodomelatonin6ME4-MT1-2-Iodomelatonin
21.43Single6PS5S-Propranolol6PS5-β2-S-Propranolol
21.43Single6PS82-Phenylmelatonin6PS8-MT1-2-Phenylmelatonin
21.43Single6TOSGSK10598656TOS-OX1-GSK1059865-Na
21.43Single6TP3Nemorexant6TP3-OX1-Nemorexant
21.43Single6TPGEMPA6TPG-OX2-EMPA
21.43Single6TPNHTL66416TPN-OX2-HTL6641
21.43Single6WJCAtropine6WJC-M1-Atropine-Muscarinic toxin 7
21.43Single6ZDVChromone 5d6ZDV-A2A-Chromone 5d-Na
21.43Single6ZG9GSK10347026ZG9-M1-GSK1034702
21.43Single7CKZDopamine7CKZ-D1-Dopamine-Mevidalen-Gs/β1/γ2
21.43Single7CMUPramipexole7CMU-D3-Pramipexole-Gi1/β1/γ2
21.43Single7F0TDopamine7F0T-D1-Dopamine-Gs/β1/γ2
21.43Single7F1ZDopamine7F1Z-D1-Dopamine-GDP-Gs/β1/γ2
21.43Single7F24Dopamine7F24-D1-Dopamine-GDP-Gs/β1/γ2
21.43Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
21.43Single7RANPubChem 1645758477RAN-5-HT2A-PubChem 164575847-chim(NtGi2L-Gs-CtGq)/β1/γ2
21.43Single7T32ZM-2413857T32-A2A-ZM-241385
21.43Single7UL3Famotidine7UL3-H2-Famotidine
21.43Single7UM7Methylergometrine7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/β1/γ2
21.43Single7VUGJNJ-635330547VUG-GPR139-JNJ-63533054-Gi1/β1/γ2
21.43Single8DPGPsilocin8DPG-5-HT2C-Psilocin-chim(NtGi2L-Gs-CtGq)/β1/γ2
21.43Single8GG5Constrained Epinephrine8GG5-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
21.43Single8GG7Constrained Epinephrine8GG7-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
21.43Single8GGLConstrained Epinephrine8GGL-β2-Constrained Epinephrine
21.43Single8GGMConstrained Epinephrine8GGM-β2-Constrained Epinephrine
21.43Single8GGPConstrained Epinephrine8GGP-β2-Constrained Epinephrine
21.43Single8H4LDoconexent8H4L-FFA4-Doconexent-chim(NtGi1-Gs-CtGq)/β1/γ2
21.43Single8IY9Niacin8IY9-HCA2-Niacin-Go/β1/γ2
21.43Single8JEI3-nitro-4-(propylamino)benzoic acid8JEI-HCAR3-3-nitro-4-(propylamino)benzoic acid-Gi1/β1/γ2
21.43Single8JERAcipimox8JER-HCA2-Acipimox-Go/β1/γ2
21.43Single8JIMMMF8JIM-HCA2-MMF-Gi1/β1/γ2
21.43Single8JLQFenoldopam8JLQ-TA1-Fenoldopam-Gs/β1/γ2
21.43Single8K5CAcipimox8K5C-HCA2-Acipimox
21.43Single8RWIStilSwitch28RWI-A2A-StilSwitch2-Na
21.43Single8UNLConstrained Epinephrine8UNL-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
21.43Single8UNOConstrained Epinephrine8UNO-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
21.43Single8UO1Constrained Epinephrine8UO1-β2-Constrained Epinephrine-GTP; Mg-Gs/β1/γ2
21.43Single8VVGGB188VVG-κ-GB18-Gi1/β1/γ2
21.43Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
21.43Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/β1/γ2
21.43Single8Y53MK50468Y53-BB3-MK5046-chim(NtGi1-Gs-CtGq)/β1/γ2
21.43Single8YN8Proxyfan8YN8-H3-Proxyfan-Go1/β1/γ2
21.43Single8ZMGPimavanserin8ZMG-5-HT2A-Pimavanserin
21.43Single8ZPNAMD31008ZPN-CXCR4-AMD3100-Cholesterol
21.43Single9ASBCa; Ca; Cyclomethyltryptophan; 9IG; PO49ASB-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
21.43Single9AVGCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVG-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs)/β1/γ2
21.43Single9BJKNaloxone9BJK-μ-Naloxone-NAM
21.43Single9CBLEpinephrine9CBL-α2a-Epinephrine-Gi1/β1/γ2
21.43Single9JKQMETH9JKQ-TA1-METH-Gs/β1/γ2
21.43Consensus5ht_on_gpOrthosteric Ligand5ht1_on_gp 5ht2_on_gp 5ht4_on_gp 5ht5_on_gp 5ht6_on_gp 5ht7_on_gp
21.43Consensusat1_offOrthosteric Ligand4YAY-AT1-ZD-7155 4ZUD-AT1-Olmesartan
21.43Consensusd3_onOrthosteric Ligand7CMV-D3-PD128907-Gi1/β1/γ2 8IRT-D3-Rotigotine-Gi1/β1/γ2 7CMU-D3-Pramipexole-Gi1/β1/γ2
21.43Consensusd3_on_gpOrthosteric Ligand7CMV-D3-PD128907-Gi1/β1/γ2 8IRT-D3-Rotigotine-Gi1/β1/γ2 7CMU-D3-Pramipexole-Gi1/β1/γ2
21.43Consensusghrelin_offOrthosteric Ligand6KO5-Ghrelin-PubChem 57400002 7F83-Ghrelin-PF-05190457
21.43Consensushca_onOrthosteric Ligandhca2_on
21.05Single5WF6UK-4320975WF6-A2A-UK-432097
21.05Single6W2YPubChem 237279706W2Y-GABAB1; GABAB1-PubChem 5311042-PubChem 23727970
21.05Single6XBJCholesterol6XBJ-SMO-Cholesterol-Gi1/β1/γ2
21.05Single7SK9CCX6627SK9-ACKR3-CCX662
21.05Single7XN9L-054,5227XN9-SST2-L-054,522
21.05Single7XY6BAY 60-65837XY6-A2B-BAY 60-6583-chim(NtGi1-Gs)/β1/γ2
21.05Single7YAEOctreotide7YAE-SST2-Octreotide-Gi1/β1/γ2
21.05Single8IA7Cholecystokinin-88IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/β1/γ2
21.05Single8X5YAstemizole8X5Y-H1-Astemizole
21.05Consensuss1p_onOrthosteric Ligands1p1_on s1p3_on s1p5_on
21.05Consensuss1p_on_gpOrthosteric Ligands1p1_on_gp s1p3_on_gp s1p5_on_gp
21.05Consensussst2_onOrthosteric Ligand7WIC-SST2-Somatostatin-14-Gi1/β1/γ2 7WIG-SST2-L-054,264-Gi1/β1/γ2 7YAE-SST2-Octreotide-Gi1/β1/γ2 7YAC-SST2-Paltusotine-Gi1/β1/γ2
21.05Consensussst2_on_gpOrthosteric Ligand7WIC-SST2-Somatostatin-14-Gi1/β1/γ2 7WIG-SST2-L-054,264-Gi1/β1/γ2 7YAE-SST2-Octreotide-Gi1/β1/γ2 7YAC-SST2-Paltusotine-Gi1/β1/γ2
20.00Single2Y02Carmoterol2Y02-β1-Carmoterol
20.00Single4DAJTiotropium4DAJ-M3-Tiotropium
20.00Single4IARErgotamine4IAR-5-HT1B-Ergotamine
20.00Single4IB4Ergotamine4IB4-5-HT2B-Ergotamine
20.00Single4MQSIperoxo4MQS-M2-Iperoxo
20.00Single4U14Tiotropium4U14-M3-Tiotropium
20.00Single4YAYZD-71554YAY-AT1-ZD-7155
20.00Single5DSGTiotropium5DSG-M4-Tiotropium
20.00Single5MZJTheophylline5MZJ-A2A-Theophylline-Na
20.00Single5UIGCmpd-15UIG-A2A-Cmpd-1
20.00Single5UNFPubChem 157800525UNF-AT2-PubChem 15780052
20.00Single6D27CAY104716D27-DP2-CAY10471
20.00Single6FFHFenobam6FFH-mGlu5-Fenobam
20.00Single6FK7PubChem 1324730346FK7-Rhodopsin-PubChem 132473034
20.00Single6FKCPubChem 1324730396FKC-Rhodopsin-PubChem 132473039
20.00Single6FKDPubChem 1373491836FKD-Rhodopsin-PubChem 137349183
20.00Single6IIVDaltroban6IIV-TP-Daltroban
20.00Single6LPJZM-2413856LPJ-A2A-ZM-241385-Na
20.00Single6LPKZM-2413856LPK-A2A-ZM-241385-Na
20.00Single6TOTLemborexant6TOT-OX1-Lemborexant
20.00Single6XBM25(S)-Epoxycholesterol6XBM-SMO-25(S)-Epoxycholesterol-Gi1/β1/γ2
20.00Single6Z10PubChem 1545855546Z10-Succinate-PubChem 154585554
20.00Single7CRHSKF839597CRH-D1-SKF83959-Gs/β1/γ2
20.00Single7F83PF-051904577F83-Ghrelin-PF-05190457
20.00Single7F8XNN90567F8X-CCKA-NN9056
20.00Single7JVQApomorphine7JVQ-D1-Apomorphine-Gs/β1/γ2
20.00Single7LJCSKF-812977LJC-D1-SKF-81297-Mevidalen-Gs/β1/γ2
20.00Single7SCGFH2107SCG-μ-FH210-Gi1/β1/γ2
20.00Single7T2GMitragynine Pseudoindoxyl7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2
20.00Single7T6VfMLFII7T6V-FPR2-ALX-fMLFII-Gi1/β1/γ2
20.00Single7TRPIperoxo7TRP-M4-Iperoxo-LY2033298-Gi1/β1/γ2
20.00Single7TYFAmylin7TYF-CT (AMY1)-Amylin-Gs/β1/γ2; RAMP1
20.00Single7UM6Lisuride7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/β1/γ2
20.00Single7VH0Ramelteon7VH0-MT2-Ramelteon-Gi1/β1/γ1
20.00Single7VIES1P7VIE-S1P1-S1P-Gi1/β1/γ2
20.00Single7W0PElabela7W0P-Apelin-Elabela-Gi1/β1/γ2
20.00Single7WC4Serotonin7WC4-5-HT2A-Serotonin
20.00Single7WKDTRH7WKD-TRH-TRH-chim(NtGi1-Gs-CtGq)/β1/γ2
20.00Single7WVYAmyloid-Beta427WVY-FPR2-ALX-Amyloid-β42-Gi2/β1/γ2
20.00Single7X2CFenoldopam7X2C-D1-Fenoldopam-Fenoldopam-Gs/β1/γ2
20.00Single7XJHIsoproterenol7XJH-β3-Isoproterenol-Gs/β1/γ2
20.00Single7YK7DC5910537YK7-RXFP4-DC591053-Gi2/β1/γ2
20.00Single8DCRDobutamine8DCR-β1-Dobutamine-Gs/β1/γ2
20.00Single8DZSGR89,6968DZS-κ-GR89,696-chim(NtGi2-Gz)/β1/γ2
20.00Single8G59TUG-8918G59-FFA4-TUG-891-chim(Gi1-CtGq)/β1/γ2
20.00Single8I7VAcipimox8I7V-HCA2-Acipimox-Gi1/β1/γ2
20.00Single8IEBA1LYA8IEB-GPR156-A1LYA
20.00Single8IRTRotigotine8IRT-D3-Rotigotine-Gi1/β1/γ2
20.00Single8J6PNiacin8J6P-HCA2-Niacin-Compound 9n-Gi1/β1/γ2
20.00Single8J6RMK68928J6R-HCA2-MK6892-Gi1/β1/γ2
20.00Single8JHNMMF8JHN-HCA2-MMF-Go/β1/γ2
20.00Single8JIINiacin8JII-HCA2-Niacin-Compound 9n-Gi1/β1/γ2
20.00Single8JLZST19368JLZ-5-HT6-ST1936-Gs/β1/γ2
20.00Single8K5DGSK2560738K5D-HCA2-GSK256073
20.00Single8PWNTheophylline8PWN-A2A-Theophylline
20.00Single8RWXStilSwitch38RWX-A2A-StilSwitch3-Na
20.00Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/β1/γ2
20.00Single8WC7ZH86678WC7-TA1-ZH8667-chim(NtGi1-Gs)/β1/γ2
20.00Single8X63Mepyramine8X63-H1-Mepyramine
20.00Single8ZH8QRF-Amide8ZH8-QRFP-QRF-Amide-Gq/β1/γ1
20.00Single9D61JDTic9D61-κ-JDTic-Gi1/β1/γ2
20.00Single9L3YRetinoic acid receptor responder protein 29L3Y-CML2-Retinoic acid receptor responder protein 2-Gi1/β1/γ2
20.00Consensus5ht5_onOrthosteric Ligand5ht5a_on
20.00Consensus5ht5a_onOrthosteric Ligand7X5H-5-HT5A-5-CT-Gi1/β1/γ2 7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/β1/γ2 7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/β1/γ2
20.00Consensusalicarboxylic_on_gpOrthosteric Ligandsuccinate_on_gp hca_on_gp
20.00Consensusclass-a_on_gpOrthosteric Ligandsensory_on_gp alicarboxylic_on_gp amine_on_gp lipid_on_gp nucleotide_on_gp peptide_on_gp protein_on_gp
20.00Consensusgi_alicarboxylicOrthosteric Ligandgi_hca gi_succinate
20.00Consensusgi_hcaOrthosteric Ligand8J6R-HCA2-MK6892-Gi1/β1/γ2 8JIM-HCA2-MMF-Gi1/β1/γ2 8IHI-HCA2-Acifran-Gi1/β1/γ2 8IHH-HCA2-LUF6283-Gi1/β1/γ2 8I7V-HCA2-Acipimox-Gi1/β1/γ2 8I7W-HCA2-GSK256073-Gi1/β1/γ2
20.00Consensusgi_nucleotideOrthosteric Ligandgi_adenosine gi_p2y
20.00Consensusgi_opioidOrthosteric Ligand8F7R-μ-Endomorphin-Gi1/β1/γ2 8EF5-μ-Fentanyl-Gi1/β1/γ2 7SCG-μ-FH210-Gi1/β1/γ2 7T2H-μ-Lofentanil-Gi1/β1/γ2 7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2 8DZP-κ-momSalB-Gi1/β1/γ2 8EF6-μ-Morphine-Gi1/β1/γ2 8F7X-NOP-Nociceptin-Gi1/β1/γ2 8EFB-μ-Oliceridine-Gi1/β1/γ2 7U2L-μ-PubChem 163201242-Gi1/β1/γ2 8EFO-μ-PZM21-Gi1/β1/γ2 8EFL-μ-SR17018-Gi1/β1/γ2 8F7Q-μ-β-Endorphin-Gi1/β1/γ2 7U2K-μ-C6-guano-Gi1/β1/γ2 8EFQ-μ-Damgo-Gi1/β1/γ2 8F7S-δ-Deltorphin-Gi1/β1/γ2 8F7W-κ-Dynorphin-Gi1/β1/γ2
20.00Consensushca2_onOrthosteric Ligand8J6R-HCA2-MK6892-Gi1/β1/γ2 8JIM-HCA2-MMF-Gi1/β1/γ2 8I7V-HCA2-Acipimox-Gi1/β1/γ2 8I7W-HCA2-GSK256073-Gi1/β1/γ2 8IHH-HCA2-LUF6283-Gi1/β1/γ2 8IHI-HCA2-Acifran-Gi1/β1/γ2
20.00Consensushca2_on_gpOrthosteric Ligand8J6R-HCA2-MK6892-Gi1/β1/γ2 8IHI-HCA2-Acifran-Gi1/β1/γ2 8IHH-HCA2-LUF6283-Gi1/β1/γ2 8I7V-HCA2-Acipimox-Gi1/β1/γ2 8JIM-HCA2-MMF-Gi1/β1/γ2 8I7W-HCA2-GSK256073-Gi1/β1/γ2
20.00Consensushca_on_gpOrthosteric Ligandhca2_on_gp
20.00Consensushistamine_offOrthosteric Ligandh1_off
20.00Consensusm4_offOrthosteric Ligand5DSG-M4-Tiotropium
20.00Consensussst5_onOrthosteric Ligand8X8L-SST5-Cortistatin-chim(NtGi1-Gs-CtGi1)/β1/γ2 8X8N-SST5-Octreotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
19.23Consensusbk2_onOrthosteric Ligand7F6H-BK2-Bradykinin-Gq/β1/γ2 7F6I-BK2-Kallidin-Gq/β1/γ2
19.23Consensusbk2_on_gpOrthosteric Ligand7F6H-BK2-Bradykinin-Gq/β1/γ2 7F6I-BK2-Kallidin-Gq/β1/γ2
19.23Consensusbradykinin_onOrthosteric Ligandbk2_on
19.23Consensusbradykinin_on_gpOrthosteric Ligandbk2_on_gp
19.23Consensusgq_bradykininOrthosteric Ligand7F6H-BK2-Bradykinin-Gq/β1/γ2 7F6I-BK2-Kallidin-Gq/β1/γ2
19.05Single6DO1Angiotensin-like peptide S1I86DO1-AT1-Angiotensin-like peptide S1I8
19.05Single7CUMPhospholipid7CUM-GABAB1, GABAB2-CGP54626-Phospholipid
19.05Single7EZKCholecystokinin-87EZK-CCKA-Cholecystokinin-8-chim(NtGi1-Gs)/β1/γ2
19.05Single8SG1Chemerin-98SG1-CML1-Chemerin-9-Gi1/β1/γ2
19.05Consensuss1p3_on_gpOrthosteric Ligand7EW3-S1P3-S1P-Gi1/β1/γ2 7EW4-S1P3-CYM5541-Gi1/β1/γ2 7EW2-S1P3-Fingolimod-Gi1/β1/γ2
18.75Single4ZJ8Suvorexant4ZJ8-OX1-Suvorexant
18.75Single5C1MBU725C1M-μ-BU72
18.75Single5TVNLSD5TVN-5-HT2B-LSD
18.75Single5WQCEMPA5WQC-OX2-EMPA
18.75Single5XPRBosentan5XPR-ETB-Bosentan
18.75Single5ZBQUR-MK-2995ZBQ-Y1-UR-MK-299
18.75Single5ZK33-quinuclidinyl-benzilate5ZK3-M2-3-quinuclidinyl-benzilate
18.75Single6D26Fevipiprant6D26-DP2-Fevipiprant
18.75Single6E67BI1671076E67-β2-BI167107-Gs (fused)
18.75Single6ME62-Phenylmelatonin6ME6-MT2-2-Phenylmelatonin
18.75Single6ME82-Phenylmelatonin6ME8-MT2-2-Phenylmelatonin
18.75Single6TP6Filorexant6TP6-OX1-Filorexant
18.75Single6W2XPubChem 237279706W2X-GABAB1, GABAB2-PubChem 5311042-PubChem 23727970
18.75Single7CFNINT-7777CFN-GPBA-INT-777-Gs/β1/γ2
18.75Single7CKXA776367CKX-D1-A77636-Gs/β1/γ2
18.75Single7EO2FTY720-P7EO2-S1P1-FTY720-P-Gi1/β1/γ2
18.75Single7EUOfMLF7EUO-FPR1-ALX-fMLF-Gi1/β1/γ2
18.75Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
18.75Single7SBFPZM217SBF-μ-PZM21-Gi1/β1/γ2
18.75Single7TRKIperoxo7TRK-M4-Iperoxo-Gi1/β1/γ2
18.75Single7VUHJNJ-635330547VUH-GPR139-JNJ-63533054-chim(Gs-CtGq)/β1/γ2
18.75Single7WIGL-054,2647WIG-SST2-L-054,264-Gi1/β1/γ2
18.75Single7Y26Octreotide7Y26-SST2-Octreotide-chim(NtGi2L-Gs-CtGq)/β1/γ2
18.75Single8DZQmomSalB8DZQ-κ-momSalB-Go/β1/γ2
18.75Single8DZRGR89,6968DZR-κ-GR89,696-chim(NtGi2-Gt3)/β1/γ2
18.75Single8GDCPGE28GDC-EP3-PGE2-Gi1/β1/γ2
18.75Single8I7WGSK2560738I7W-HCA2-GSK256073-Gi1/β1/γ2
18.75Single8J18(3R)-3-Hydroxydodecanoic acid8J18-GPR84-(3R)-3-Hydroxydodecanoic acid-Gi1/β1/γ2
18.75Single8S4DCMF-0198S4D-Apelin-CMF-019
18.75Single8TF5Oleic acid8TF5-GPR6-Oleic acid
18.75Single8TH4Losartan8TH4-AT1-Losartan-AT118-L Nanobody
18.75Single8UUJFCH-22964138UUJ-HCA2-FCH-2296413-Gi1/β1/γ2
18.75Single8VVEnorBNI8VVE-κ-norBNI-Gi1/β1/γ2
18.75Single8WGBW9R8WGB-mGlu4; mGlu2-Glutammate-W9R-Gi3/β1/γ2
18.75Single8X0CVU04244658X0C-mGlu5; mGlu5-Quisqualate-VU0424465
18.75Single8X0DVU04244658X0D-mGlu5; mGlu5-Quisqualate-VU0424465
18.75Single8X0DVU04244658X0D-mGlu5; mGlu5-Quisqualate-VU0424465
18.75Single8YNSSNAP-948478YNS-MCH1-SNAP-94847
18.75Single8ZPTPrRP208ZPT-PrRP-PrRP20-chim(NtGi1-Gs-CtGq)/β1/γ2
18.75Single9EAHOlmesartan9EAH-AT1-Olmesartan-Nanobody AT209
18.75Single9IYBProstaglandin9IYB-DP2-Prostaglandin-A1D5Q-Gi1/β1/γ2
18.75Consensusd1_onOrthosteric Ligand7F0T-D1-Dopamine-Gs/β1/γ2 7CKY-D1-PW0464-Gs/β1/γ2 8IRR-D1-Rotigotine-Gs/β1/γ2 7JV5-D1-SKF81297-Gs/β1/γ2 7JVP-D1-SKF83959-Gs/β1/γ2 7X2D-D1-Tavapadon-Gs/β1/γ2 7CKX-D1-A77636-Gs/β1/γ2 7JVQ-D1-Apomorphine-Gs/β1/γ2 7CKW-D1-Fenoldopam-Gs/β1/γ2
18.75Consensusd4_onOrthosteric Ligand8IRU-D4-Rotigotine-chim(NtGi1-Gs-CtGi1)/β1/γ2
18.75Consensusdp2_offOrthosteric Ligand6D26-DP2-Fevipiprant
18.75Consensusdp_offOrthosteric Liganddp2_off
18.75Consensush1_offOrthosteric Ligand8X63-H1-Mepyramine 3RZE-H1-Cidoxepin 8X5Y-H1-Astemizole
18.75Consensusnucleotide_onOrthosteric Ligandadenosine_on p2y_on
18.75Consensusrxfp4_onOrthosteric Ligand7YK7-RXFP4-DC591053-Gi2/β1/γ2 7YJ4-RXFP4-INSL5-Gi2/β1/γ2 7YK6-RXFP4-PubChem 138319674-Gi2/β1/γ2
18.75Consensusrxfp4_on_gpOrthosteric Ligand7YK7-RXFP4-DC591053-Gi2/β1/γ2 7YJ4-RXFP4-INSL5-Gi2/β1/γ2 7YK6-RXFP4-PubChem 138319674-Gi2/β1/γ2
18.75Consensuss1p_offOrthosteric Ligands1p1_off s1p5_off
18.52Consensusbb2_onOrthosteric Ligand7W40-BB2-Bombesin-chim(NtGi1L-Gq)/β1/γ2 7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/β1/γ2
18.52Consensusbb2_on_gpOrthosteric Ligand7W40-BB2-Bombesin-chim(NtGi1L-Gq)/β1/γ2 7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/β1/γ2
18.52Consensusbombesin_onOrthosteric Ligandbb2_on
18.52Consensusbombesin_on_gpOrthosteric Ligandbb2_on_gp
18.52Consensusgq_bombesinOrthosteric Ligand7W40-BB2-Bombesin-chim(NtGi1L-Gq)/β1/γ2 7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/β1/γ2
18.18Single6OT025(S)-Epoxycholesterol6OT0-SMO-25(S)-Epoxycholesterol-Gi1/β1/γ2
18.18Single8A2OTheophylline8A2O-A2A-Theophylline-Na
18.18Single8XZGApelin-138XZG-Apelin-Apelin-13-Gi1/β1/γ2
18.18Single8XZHMM078XZH-Apelin-MM07-Gi1/β1/γ2
18.18Single9B54A1AIW9B54-CB1-A1AIW-Gi1/β1/γ2
18.18Single9C2FCa; Ca; Tryptophan; '6218; PO49C2F-CaS-Ca-Ca; Ca; Tryptophan; '6218; PO4
18.18Single9CHUNoradrenaline9CHU-β2-Noradrenaline
18.18Consensusgs_class-aOrthosteric Ligandgs_peptide gs_nucleotide gs_amine
18.18Consensusgs_histamineOrthosteric Ligand8POK-H2-Histamine-Gs/β1/γ2
18.18Consensush2_onOrthosteric Ligand8POK-H2-Histamine-Gs/β1/γ2
17.65Single3P0GBI1671073P0G-β2-BI167107
17.65Single3PDSHydroxybenzylisoproterenol3PDS-β2-Hydroxybenzylisoproterenol
17.65Single3SN6BI1671073SN6-β2-BI167107-Gs/β1/γ2
17.65Single4DJHJDTic4DJH-κ-JDTic
17.65Single4IAQDihydroergotamine4IAQ-5-HT1B-Dihydroergotamine
17.65Single4Z34ONO-97803074Z34-LPA1-ONO-9780307
17.65Single5ZBHBMS-1938855ZBH-Y1-BMS-193885
17.65Single5ZHPPubChem 1348285895ZHP-M3-PubChem 134828589
17.65Single6NI3BI1671076NI3-β2-BI167107-Gs/β1/γ2
17.65Single6O3CCholesterol6O3C-SMO-SAG21k-Cholesterol
17.65Single6WGTLSD6WGT-5-HT2A-LSD
17.65Single7B6WCyclazosin7B6W-α1b-Cyclazosin
17.65Single7CKYPW04647CKY-D1-PW0464-Gs/β1/γ2
17.65Single7E2ZAripiprazole7E2Z-5-HT1A-Aripiprazole-Gi1/β1/γ2
17.65Single7EW1Siponimod7EW1-S1P5-Siponimod-Gi1/β1/γ2
17.65Single7F58THIQ7F58-MC4-THIQ-Gs/β1/γ2
17.65Single7JV5SKF812977JV5-D1-SKF81297-Gs/β1/γ2
17.65Single7JVPSKF839597JVP-D1-SKF83959-Gs/β1/γ2
17.65Single7M8W15r-Methyl-Prostaglandin D27M8W-DP2-15r-Methyl-Prostaglandin D2-Na
17.65Single7XAVLanreotide7XAV-SST2-Lanreotide-Gi1/β1/γ2
17.65Single7XTQR3997XTQ-GPBA-R399-Gs/β1/γ2
17.65Single8E0GBU728E0G-μ-BU72
17.65Single8EFLSR170188EFL-μ-SR17018-Gi1/β1/γ2
17.65Single8HDOBAY 60-65838HDO-A2B-BAY 60-6583-Gs/β1/γ2
17.65Single8ID6Oleic acid8ID6-FFA4-Oleic acid-Gi1/β1/γ2
17.65Single8IHBGSK2560738IHB-HCA2-GSK256073-Gi1/β1/γ2
17.65Single8IHHLUF62838IHH-HCA2-LUF6283-Gi1/β1/γ2
17.65Single8IRURotigotine8IRU-D4-Rotigotine-chim(NtGi1-Gs-CtGi1)/β1/γ2
17.65Single8JXVClozapine8JXV-H4-Clozapine-Gi1/β1/γ2
17.65Single8JXWVUF68848JXW-H4-VUF6884-Gi1/β1/γ2
17.65Single8WU1PubChem 1190256658WU1-CB1-PubChem 119025665-Arrestin2
17.65Single8X0FVU04244658X0F-mGlu5; mGlu5-Quisqualate-VU0424465
17.65Single8XIPPasireotide8XIP-SST1-Pasireotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
17.65Single9F33FOB02-04A9F33-D3-FOB02-04A-Go1/β1/γ2
17.65Consensusd4_on_gpOrthosteric Ligand8IRU-D4-Rotigotine-chim(NtGi1-Gs-CtGi1)/β1/γ2
17.65Consensusffa2_onOrthosteric Ligand8J22-FFA2-TUG-1375-Gi1/β1/γ2
17.65Consensusgi_relaxinOrthosteric Ligand7YK7-RXFP4-DC591053-Gi2/β1/γ2 7YJ4-RXFP4-INSL5-Gi2/β1/γ2 7YK6-RXFP4-PubChem 138319674-Gi2/β1/γ2
17.65Consensuskop_offOrthosteric Ligand4DJH-κ-JDTic
17.65Consensusm3_offOrthosteric Ligand4U15-M3-Tiotropium 4U16-M3-N-Methyl-Scopolamine 5ZHP-M3-PubChem 134828589
17.65Consensusnpy1_offOrthosteric Ligand5ZBH-Y1-BMS-193885 5ZBQ-Y1-UR-MK-299
17.65Consensusprotein_offOrthosteric Ligandchemokine_off grh_off
17.65Consensusrelaxin_onOrthosteric Ligandrxfp4_on
17.65Consensusrelaxin_on_gpOrthosteric Ligandrxfp4_on_gp
17.65Consensuss1p5_onOrthosteric Ligand7EW1-S1P5-Siponimod-Gi1/β1/γ2
17.65Consensuss1p5_on_gpOrthosteric Ligand7EW1-S1P5-Siponimod-Gi1/β1/γ2
17.39Single5WB2CX3CL1.355WB2-US28-CX3CL1.35
17.39Single6WIVPubChem 52923113; PubChem 529246456WIV-GABAB1, GABAB2-PubChem 52923113; PubChem 52924645
17.39Single7DW9AVP7DW9-V2-AVP-chim(NtGi1-Gs)/β1/γ2
17.39Single7T10Somatostatin-147T10-SST2-Somatostatin-14-Gi3/β1/γ2
17.39Single8H4KGW95088H4K-FFA4-GW9508-chim(NtGi1-Gs-CtGq)/β1/γ2
17.39Single8IHFMK68928IHF-HCA2-MK6892-Gi1/β1/γ2
17.39Single8J6IMK68928J6I-HCA2-MK6892-Gi1/β1/γ2
17.39Single8WSTPro-MCH8WST-MCH2-Pro-MCH-chim(NtGi1L-Gs-CtGq)/β1/γ2
17.39Single9BKKCholecystokinin-89BKK-CCKA-Cholecystokinin-8-chim(NtGi1-Gs-CtGq)/β1/γ2
17.39Consensusapelin_onOrthosteric Ligand8XZH-Apelin-MM07-Gi1/β1/γ2 7W0M-Apelin-PubChem 122701908-Gi1/β1/γ2 8XZJ-Apelin-WN353-Gi1/β1/γ2 8XZF-Apelin-WN561-Gi1/β1/γ2 8XZG-Apelin-Apelin-13-Gi1/β1/γ2
17.39Consensusapelin_on_gpOrthosteric Ligand8XZH-Apelin-MM07-Gi1/β1/γ2 7W0M-Apelin-PubChem 122701908-Gi1/β1/γ2 8XZJ-Apelin-WN353-Gi1/β1/γ2 8XZF-Apelin-WN561-Gi1/β1/γ2 8XZG-Apelin-Apelin-13-Gi1/β1/γ2
17.39Consensusgi_class-aOrthosteric Ligandgi_peptide gi_sensory gi_alicarboxylic gi_amine gi_lipid gi_nucleotide gi_protein
17.39Consensusgs_vasop-oxyOrthosteric Ligand7DW9-V2-AVP-chim(NtGi1-Gs)/β1/γ2
17.39Consensusv2_onOrthosteric Ligand7DW9-V2-AVP-chim(NtGi1-Gs)/β1/γ2
17.39Consensusv2_on_gpOrthosteric Ligand7DW9-V2-AVP-chim(NtGi1-Gs)/β1/γ2
17.39Consensusvasop-oxy_onOrthosteric Ligandv2_on
17.39Consensusvasop-oxy_on_gpOrthosteric Ligandv2_on_gp
16.67Single4N4WSANT-14N4W-SMO-SANT-1
16.67Single4Z36ONO-30805734Z36-LPA1-ONO-3080573
16.67Single5X33BIIL2605X33-BLT1-BIIL260
16.67Single6AK3Dinoprostone IPGE26AK3-EP3-Dinoprostone IPGE2
16.67Single6FK9PubChem 1324730366FK9-Rhodopsin-PubChem 132473036
16.67Single6IIURamatroban6IIU-TP-Ramatroban
16.67Single6ME5Agomelatine6ME5-MT1-Agomelatine
16.67Single6MXTSalmeterol6MXT-β2-Salmeterol
16.67Single6W2YPubChem 237279706W2Y-GABAB1; GABAB1-PubChem 5311042-PubChem 23727970
16.67Single7BZ2Arformoterol7BZ2-β2-Arformoterol-Gs/β1/γ2
16.67Single7D77Hydrocortisone7D77-ADGRG3-Hydrocortisone-Go/β1/γ2
16.67Single7DH5Mirabegron7DH5-β3-Mirabegron-Gs/β1/γ2
16.67Single7EPENAM5637EPE-mGlu2; mGlu2-NAM563
16.67Single7F55Bremelanotide7F55-MC4-Bremelanotide-Gs/β1/γ2
16.67Single7F6HBradykinin7F6H-BK2-Bradykinin-Gq/β1/γ2
16.67Single7F6IKallidin7F6I-BK2-Kallidin-Gq/β1/γ2
16.67Single7SUSPubChem 1227019087SUS-Apelin-PubChem 122701908
16.67Single7TYWCalcitonin-17TYW-CT (AMY1)-Calcitonin-1-Gs/β1/γ2; RAMP1
16.67Single7WC5Psilocin7WC5-5-HT2A-Psilocin
16.67Single7XW5ML1097XW5-TSH-TSH-ML109-Gs/β1/γ2
16.67Single7XW6ML1097XW6-TSH-M22 Fab-ML109-Gs/β1/γ2
16.67Single7YMJTamsulosin7YMJ-Alpha1A-Tamsulosin
16.67Single8DPILorcaserin8DPI-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/β1/γ2
16.67Single8EITDoconexent8EIT-FFA1-Doconexent-chim(NtGi1L-Gs-CtGq)/β1/γ2
16.67Single8F76Propanoic acid8F76-OR51E2-Propanoic acid-Gs/β1/γ2
16.67Single8GGEConstrained Epinephrine8GGE-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
16.67Single8GGFConstrained Epinephrine8GGF-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
16.67Single8GH1Constrained Epinephrine8GH1-β2-Constrained Epinephrine
16.67Single8I9AEP548I9A-C3aB-EP54-chim(NtGi1-Gs-CtGq)/β1/γ2
16.67Single8IA8E7 peptide8IA8-C3aB-E7 peptide-Gi1/β1/γ2
16.67Single8IYWGSK2560738IYW-HCA2-GSK256073-Go/β1/γ2
16.67Single8J21Butyric acid8J21-FFA3-Butyric acid-Gi1/β1/γ2
16.67Single8J24Acetic acid8J24-FFA2-Acetic acid-Gi1/β1/γ2
16.67Single8JEF(3S)-3-hydroxyoctanoic acid8JEF-HCA3-(3S)-3-hydroxyoctanoic acid-Gi1/β1/γ2
16.67Single8JJLOlodaterol8JJL-β2-Olodaterol
16.67Single8WWKMCH8WWK-MCH1-MCH-Gi1/β1/γ2
16.67Single8WWMMCH8WWM-MCH1-MCH-Gi1/β1/γ2
16.67Single8X8NOctreotide8X8N-SST5-Octreotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
16.67Single8X9UMetenolone8X9U-ADGRD1-Metenolone-chim(NtGi1-Gs)/β1/γ2
16.67Single8XGOTAK4488XGO-Kiss1-TAK448-chim(NtGi1-Gq)/β1/γ2
16.67Single8XJNCloprosetnol8XJN-TP-Cloprosetnol-chim(NtGi1-Gs-CtGq)/β1/γ2
16.67Single8XQEApelin-138XQE-Apelin-Apelin-13-Gi1/β1/γ2
16.67Consensus5ht2_onOrthosteric Ligand5ht2b_on
16.67Consensus5ht2b_onOrthosteric Ligand7SRR-5-HT2B-LSD-chim(NtGi2L-Gs-CtGq)/β1/γ2
16.67Consensusalpha1_offOrthosteric Ligandalpha1a_off
16.67Consensusalpha1a_offOrthosteric Ligand7YMJ-Alpha1A-Tamsulosin
16.67Consensusc3a_onOrthosteric Ligand8HK2-C3aB-C3a anaphylatoxin-Gi1/β1/γ2 8IA8-C3aB-E7 peptide-Gi1/β1/γ2
16.67Consensuscannabinoid_offOrthosteric Ligandcb2_off cb1_off
16.67Consensuschemokine_offOrthosteric Ligandccr_off cxcr_off
16.67Consensuscml1_on_gpOrthosteric Ligand7YKD-CML1-Chemerin-9-Gi1/β1/γ2
16.67Consensuscxcr_offOrthosteric Ligandcxcr3_off cxcr4_off
16.67Consensusffa2_on_gpOrthosteric Ligand8J22-FFA2-TUG-1375-Gi1/β1/γ2
16.67Consensusffa3_onOrthosteric Ligand8J21-FFA3-Butyric acid-Gi1/β1/γ2
16.67Consensusffa3_on_gpOrthosteric Ligand8J21-FFA3-Butyric acid-Gi1/β1/γ2
16.67Consensusgi_apelinOrthosteric Ligand8XZH-Apelin-MM07-Gi1/β1/γ2 7W0M-Apelin-PubChem 122701908-Gi1/β1/γ2 8XZJ-Apelin-WN353-Gi1/β1/γ2 8XZF-Apelin-WN561-Gi1/β1/γ2 8XZG-Apelin-Apelin-13-Gi1/β1/γ2
16.67Consensusleukotriene_offOrthosteric Ligandblt_off cyslt_off
16.67Consensuslpa1_offOrthosteric Ligand4Z36-LPA1-ONO-3080573 4Z35-LPA1-ONO-9910539 4Z34-LPA1-ONO-9780307
16.67Consensuslpa_offOrthosteric Ligandlpa1_off
16.67Consensuslpl_offOrthosteric Ligands1p_off lpa_off
16.67Consensusm4_onOrthosteric Ligand7TRS-M4-Acetylcholine-Gi1/β1/γ2 7V6A-M4-PubChem 9864275-Gi1/β1/γ2 8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/β1/γ2 7TRK-M4-Iperoxo-Gi1/β1/γ2
16.67Consensusm4_on_gpOrthosteric Ligand7TRS-M4-Acetylcholine-Gi1/β1/γ2 7V6A-M4-PubChem 9864275-Gi1/β1/γ2 8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/β1/γ2 7TRK-M4-Iperoxo-Gi1/β1/γ2
16.67Consensusopioid_onOrthosteric Ligandmop_on nop_on dop_on kop_on
16.00Single7W3ZGastrin Releasing Peptide7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/β1/γ2
16.00Single7YKDChemerin-97YKD-CML1-Chemerin-9-Gi1/β1/γ2
16.00Single8H0PNMB308H0P-BB1-NMB30-chim(NtGi1-Gs-CtGq)/β1/γ2
16.00Single8XQFApelin-138XQF-Apelin-Apelin-13-Gi1/β1/γ2
16.00Consensusccr_offOrthosteric Ligandccr2_off ccr5_off
16.00Consensusopioid_on_gpOrthosteric Ligandmop_on_gp nop_on_gp dop_on_gp kop_on_gp
15.79Single4Z35ONO-99105394Z35-LPA1-ONO-9910539
15.79Single6BQGErgotamine6BQG-5-HT2C-Ergotamine
15.79Single7EZHCholecystokinin-87EZH-CCKA-Cholecystokinin-8-Gi1/β1/γ2
15.79Single7EZMCholecystokinin-87EZM-CCKA-Cholecystokinin-8-chim(NtGsL-Gq)/β1/γ2
15.79Single7PIUSetmelanotide7PIU-MC4-Setmelanotide-Gs/β1/γ2
15.79Single7QVMOxytocin7QVM-OT-Oxytocin-chim(NtGi1-Go-CtGq)/β1/γ2
15.79Single7X2DTavapadon7X2D-D1-Tavapadon-Gs/β1/γ2
15.79Single7Y65C5a peptide7Y65-C5a1-C5a peptide-Gi1/β1/γ2
15.79Single8I95EP548I95-C3aB-EP54-Go/β1/γ2
15.79Single8ID8TUG-8918ID8-FFA4-TUG-891-Gi1/β1/γ2
15.79Single8J19LY2378J19-GPR84-LY237-Gi1/β1/γ2
15.79Single8XJOU466198XJO-TP-U46619-chim(NtGi1-Gs-CtGq)/β1/γ2
15.79Single8XVJMacitentan8XVJ-ETA-Macitentan
15.79Single9EAILosartan9EAI-AT1-Losartan-Nanobody AT209
15.79Consensusc3a_on_gpOrthosteric Ligand8HK2-C3aB-C3a anaphylatoxin-Gi1/β1/γ2 8IA8-C3aB-E7 peptide-Gi1/β1/γ2
15.79Consensusccka_onOrthosteric Ligand7EZH-CCKA-Cholecystokinin-8-Gi1/β1/γ2
15.79Consensusccka_on_gpOrthosteric Ligand7EZH-CCKA-Cholecystokinin-8-Gi1/β1/γ2
15.79Consensuschemerin_onOrthosteric Ligandcml1_on
15.79Consensusfp-alpha_on_gpOrthosteric Ligand8IUK-FP-alpha-PGF2-α-chim(NtGi1-Gs-CtGq)/β1/γ2 8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/β1/γ2 8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/β1/γ2
15.79Consensuskop_on_gpOrthosteric Ligand8F7W-κ-Dynorphin-Gi1/β1/γ2 8DZS-κ-GR89,696-chim(NtGi2-Gz)/β1/γ2 8DZP-κ-momSalB-Gi1/β1/γ2
15.79Consensusprostanoid_onOrthosteric Ligandtp_on fp-alpha_on
15.79Consensusprostanoid_on_gpOrthosteric Ligandtp_on_gp fp-alpha_on_gp
15.79Consensustp_onOrthosteric Ligand8XJO-TP-U46619-chim(NtGi1-Gs-CtGq)/β1/γ2
15.79Consensustp_on_gpOrthosteric Ligand8XJO-TP-U46619-chim(NtGi1-Gs-CtGq)/β1/γ2
15.38Single3OE9IT1t3OE9-CXCR4-IT1t
15.38Single6FK6PubChem 1324730336FK6-Rhodopsin-PubChem 132473033
15.38Single6P9XCorticoliberin6P9X-CRF1-Corticoliberin-Gs/β1/γ2
15.38Single6PGSGeraniol6PGS-Rhodopsin-Geraniol-Gt(CT)
15.38Single6TP4ACT-4622066TP4-OX1-ACT-462206
15.38Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
15.38Single7EIBDes-Arg10-Kallidin7EIB-BK1-Des-Arg10-Kallidin-chim(NtGi1-Gs-CtGq)/β1/γ2
15.38Single7SRQLSD7SRQ-5-HT2B-LSD
15.38Single7TYNCalcitonin-17TYN-CT-Calcitonin-1-Gs/β1/γ2
15.38Single7XATSomatostatin-147XAT-SST2-Somatostatin-14-Gi1/β1/γ2
15.38Single7XKFBeta-Hydroxyandrosterone7XKF-ADGRG2-β-Hydroxyandrosterone-Gs/β1/γ2
15.38Single7XTASerotonin7XTA-5-HT4-Serotonin-Gi1/β1/γ2
15.38Single7XTBSerotonin7XTB-5-HT6-Serotonin-Gs/β1/γ2
15.38Single8DPFLorcaserin8DPF-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/β1/γ2
15.38Single8EF6Morphine8EF6-μ-Morphine-Gi1/β1/γ2
15.38Single8FEG(DNCP)-Beta-Naloxamine8FEG-κ-(DNCP)-β-Naloxamine-Gi1/β1/γ2
15.38Single8IHIAcifran8IHI-HCA2-Acifran-Gi1/β1/γ2
15.38Single8JILNiacin8JIL-HCA2-Niacin-Gi1/β1/γ2
15.38Single8JPNCis-Epoxysuccinic acid8JPN-Succinate-Cis-Epoxysuccinic acid-Gi1/β1/γ1
15.38Single8WP1Cis-Epoxysuccinic acid8WP1-Succinate-Cis-Epoxysuccinic acid-Gi1/β1/γ2
15.38Single8WWLMCH8WWL-MCH1-MCH-Gi1/β1/γ2
15.38Single8X2KOleic monoethanolamide8X2K-GPR3-Oleic monoethanolamide-chim(NtGi1-Gs)/β1/γ2
15.38Single8YKWSuccinic acid8YKW-Succinate-Succinic acid-Gi1/β1/γ1
15.38Single8YN2Histamine8YN2-H1-Histamine-chim(NtGi1L-Gs-CtGq)/β1/γ2
15.38Single8ZJGChemerin8ZJG-CML1-Chemerin-Gi1/β1/γ2
15.38Single9B9Y7DY9B9Y-CB1-7DY
15.38Single9IJEEpinephrine9IJE-β3-Epinephrine-chim(NtGi1-Gs)/β1/γ2
15.38Single9L3ZLRH7-C29L3Z-CML1-LRH7-C2
15.38Consensus5ht4_onOrthosteric Ligand7XTA-5-HT4-Serotonin-Gi1/β1/γ2
15.38Consensus5ht4_on_gpOrthosteric Ligand7XTA-5-HT4-Serotonin-Gi1/β1/γ2
15.38Consensusgq_peptideOrthosteric Ligandgq_cck gq_kisspeptin gq_bradykinin gq_bombesin gq_angiotensin
15.00Single5EE7MK08935EE7-Glucagon-MK0893
15.00Single5ZTYAM102575ZTY-CB2-AM10257
15.00Single7F2OBradykinin7F2O-BK2-Bradykinin-chim(NtGi1-Gs-CtGq)/β1/γ2
15.00Single7F8WGastrin-177F8W-CCKB-Gastrin-17-chim(NtGsL-Gq)/β1/γ2
15.00Single8H4IDoconexent8H4I-FFA4-Doconexent-chim(NtGi1-Gs)/β1/γ2
15.00Single8IEIA1LYA8IEI-GPR156-A1LYA
15.00Single8IUMTafluprost acid8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/β1/γ2
15.00Single8J22TUG-13758J22-FFA2-TUG-1375-Gi1/β1/γ2
15.00Single8JBFSenktide8JBF-NK3-Senktide-chim(NtGi1-Gs-CtGq)/β1/γ2
15.00Single8QJ2pN1628QJ2-MC4-pN162-Gs
15.00Single8Z74Agonistic antibody8Z74-Apelin-Agonistic antibody
15.00Consensuscb2_offOrthosteric Ligand5ZTY-CB2-AM10257
15.00Consensuscxcr4_offOrthosteric Ligand4RWS-CXCR4-vMIP-II 3OE0-CXCR4-CVX15 3OE6-CXCR4-IT1t
15.00Consensuscxcr_on_gpOrthosteric Ligandcxcr3_on_gp cxcr4_on_gp cxcr1_on_gp cxcr2_on_gp
15.00Consensusformylpeptide_onOrthosteric Ligandfpr2-alx_on fpr1-alx_on
14.81Single6PB1Urocortin6PB1-CRF2-Urocortin-chim(NtGi1-Gs)/β1/γ2
14.81Single6UUSAdrenomedullin6UUS-CT Like (AM2)-Adrenomedullin-Gs/β1/γ2; RAMP3
14.81Single8WWNMCH8WWN-MCH1-MCH-Gi1/β1/γ2
14.81Single8Y52BA18Y52-BB3-BA1-chim(NtGi1-Gs-CtGq)/β1/γ2
14.71Single8F0JPramlintide Analogue San458F0J-CT-Pramlintide Analogue San45-Gs/β1/γ2
14.29Single3V2WPubChem 518926453V2W-S1P1-PubChem 51892645
14.29Single5GLHEndothelin-15GLH-ETB-Endothelin-1
14.29Single5OLOTozadenant5OLO-A2A-Tozadenant-Na
14.29Single5ZKQABT-4915ZKQ-PAF-ABT-491
14.29Single6AKXA4R6AKX-CCR5-A4R
14.29Single6AKYMaraviroc6AKY-CCR5-Maraviroc
14.29Single6DS0Ly2660976DS0-5-HT2B-Ly266097
14.29Single6IGKEndothelin-36IGK-ETB-Endothelin-3
14.29Single6ME2Ramelteon6ME2-MT1-Ramelteon
14.29Single6ME9Ramelteon6ME9-MT2-Ramelteon
14.29Single6PB0Urocortin6PB0-CRF1-Urocortin-chim(NtGi1-Gs)/β1/γ2
14.29Single6WIVPubChem 52923113; PubChem 529246456WIV-GABAB1, GABAB2-PubChem 52923113; PubChem 52924645
14.29Single7BR3Elagolix7BR3-GnRH1-Elagolix
14.29Single7F1ODopamine7F1O-D1-Dopamine-GDP; Mg-Gs/β1/γ2
14.29Single7F54Afamelanotide7F54-MC4-Afamelanotide-Gs/β1/γ2
14.29Single7F8ULintitript7F8U-CCKA-Lintitript
14.29Single7QA8Peptide7QA8-STE2-Peptide
14.29Single7QA8Peptide7QA8-STE2-Peptide
14.29Single7SRRLSD7SRR-5-HT2B-LSD-chim(NtGi2L-Gs-CtGq)/β1/γ2
14.29Single7SRSLSD7SRS-5-HT2B-LSD-Arrestin2
14.29Single7T6SPubChem 247763417T6S-FPR2-ALX-PubChem 24776341-Gi1/β1/γ2
14.29Single7T6UCGEN-855A7T6U-FPR2-ALX-CGEN-855A-Gi1/β1/γ2
14.29Single7TUZ7-alpha,25-dihydroxycholesterol7TUZ-GPR183-7-α,25-dihydroxycholesterol-Gi1/β1/γ2
14.29Single7VDLCortistatin-147VDL-MRGPRX2-Cortistatin-14-Gi1/β1/γ2
14.29Single7VUJJNJ-635330547VUJ-GPR139-JNJ-63533054-GDP-chim(Gs-CtGq)/β1/γ2
14.29Single7W0MPubChem 1227019087W0M-Apelin-PubChem 122701908-Gi1/β1/γ2
14.29Single7W0OElabela7W0O-Apelin-Elabela-Gi1/β1/γ2
14.29Single7W53Neuromedin-U-257W53-NMUR1-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
14.29Single7X2FDopamine7X2F-D1-Dopamine-Mevidalen-Gs/β1/γ2
14.29Single7XAUOctreotide7XAU-SST2-Octreotide-Gi1/β1/γ2
14.29Single7XRRLemborexant7XRR-OX2-Lemborexant
14.29Single8DWGML3828DWG-MRGPRX1-Proenkephalin-A-ML382-chim(NtGi2L-Gs-CtGq)/β1/γ2
14.29Single8EFOPZM218EFO-μ-PZM21-Gi1/β1/γ2
14.29Single8F2BPramlintide Analogue San458F2B-CT (AMY3)-Pramlintide Analogue San45-Gs/β1/γ2; RAMP3
14.29Single8IEPA1LYA8IEP-GPR156-A1LYA
14.29Single8IEPA1LYA8IEP-GPR156-A1LYA
14.29Single8J20Valeric acid8J20-FFA3-Valeric acid-AR420626-Gi1/β1/γ2
14.29Single8J6LNiacin8J6L-HCA2-Niacin-Gi1/β1/γ2
14.29Single8JPPSuccinic acid8JPP-Succinate-Succinic acid-chim(Gs-CtGq)/β1/γ1
14.29Single8JSOAMPH8JSO-TA1-AMPH-chim(NtGi1-Gs)/β1/γ2
14.29Single8K3ZCXCL128K3Z-CXCR4-CXCL12-Gi1/β1/γ1
14.29Single8KIGSHU91198KIG-MC3-SHU9119-Ca
14.29Single8T3SButyric acid8T3S-FFA2-Butyric acid-chim(NtGi2L-Gs-CtGq)/β1/γ2
14.29Single8U8FPalmitic Acid8U8F-GPR3-Palmitic Acid-Gs/β1/γ2
14.29Single8UTDMK19038UTD-HCA2-MK1903-Gi1/β1/γ2
14.29Single8WKYPG-9348WKY-MC4-PG-934
14.29Single8WZ2Orexigenic Neuropeptide QRFP8WZ2-QRFP-Orexigenic Neuropeptide QRFP-chim(NtGi1L-Gs-CtGq)/β1/γ2
14.29Single8YUTAmthamine8YUT-H2-Amthamine-Gs/β1/γ2
14.29Single8ZCJPasireotide8ZCJ-SST5-Pasireotide-Gi1/β1/γ1
14.29Single9BQJRO769BQJ-μ-RO76-Gi1/β1/γ2
14.29Consensus5ht2_on_gpOrthosteric Ligand5ht2b_on_gp
14.29Consensus5ht2b_on_gpOrthosteric Ligand7SRR-5-HT2B-LSD-chim(NtGi2L-Gs-CtGq)/β1/γ2
14.29Consensusccr5_on_gpOrthosteric Ligand7O7F-CCR5-6P4-CCL5-Gi1/β1/γ1 7F1Q-CCR5-MIP-1a-Gi1/β1/γ2
14.29Consensuschemerin_on_gpOrthosteric Ligandcml1_on_gp
14.29Consensuscml1_onOrthosteric Ligand7YKD-CML1-Chemerin-9-Gi1/β1/γ2
14.29Consensuscxcr4_onOrthosteric Ligand8K3Z-CXCR4-CXCL12-Gi1/β1/γ1
14.29Consensusgi_chemerinOrthosteric Ligand7YKD-CML1-Chemerin-9-Gi1/β1/γ2
14.29Consensusgnrh1_offOrthosteric Ligand7BR3-GnRH1-Elagolix
14.29Consensusmc4_onOrthosteric Ligand7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2 7F58-MC4-THIQ-Gs/β1/γ2 7F54-MC4-Afamelanotide-Gs/β1/γ2 7F53-MC4-α-MSH-Gs/β1/γ2 7F55-MC4-Bremelanotide-Gs/β1/γ2
14.29Consensusnk3_onOrthosteric Ligand8JBF-NK3-Senktide-chim(NtGi1-Gs-CtGq)/β1/γ2
14.29Consensusnk3_on_gpOrthosteric Ligand8JBF-NK3-Senktide-chim(NtGi1-Gs-CtGq)/β1/γ2
14.29Consensusnmur1_on_gpOrthosteric Ligand7W53-NMUR1-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
14.29Consensusorexin_offOrthosteric Ligandox2_off ox1_off
14.29Consensusox2_offOrthosteric Ligand5WQC-OX2-EMPA 6TPN-OX2-HTL6641 7XRR-OX2-Lemborexant 6TPJ-OX2-Suvorexant
14.29Consensuspaf_offOrthosteric Ligand5ZKQ-PAF-ABT-491
14.29Consensuss1p1_offOrthosteric Ligand3V2W-S1P1-PubChem 51892645
13.79Single7TZFAmylin7TZF-CT (AMY3)-Amylin-Gs/β1/γ2; RAMP3
13.64Single5XJM(Sar1,Ile8)-Angiotensin II5XJM-AT2-(Sar1,Ile8)-Angiotensin II
13.64Single6WHCGlu16 analog of GCG6WHC-Glucagon-Glu16 analog of GCG-Gs/β1/γ2
13.64Single7PIVSetmelanotide7PIV-MC4-Setmelanotide-Gs/β1/γ2
13.64Single7RKMFractalkine7RKM-US28-Fractalkine-Gi1/β1/γ2
13.64Single7TRYUrocortin7TRY-CRF2-Urocortin-chim(NtGi1-G11)/β1/γ2
13.64Single7W0NElabela7W0N-Apelin-Elabela-Gi1/β1/γ2
13.64Single7WJ5Somatostatin-147WJ5-SST2-Somatostatin-14-Gi1/β1/γ2
13.64Single7XMSSomatostatin-147XMS-SST4-Somatostatin-14-Gi1/β1/γ2
13.64Single8IEBA1LYA8IEB-GPR156-A1LYA
13.64Single8IOCGamma-MSH8IOC-MC3-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
13.64Single8JZZC5a-desArg8JZZ-C5a1-C5a-desArg-Go/β1/γ2
13.64Single8Z7JAgonistic antibody8Z7J-Apelin-Agonistic antibody-Gi1/β1/γ2
13.64Consensuscompl-peptide_onOrthosteric Ligandc5a1_on c3a_on
13.64Consensusformylpeptide_on_gpOrthosteric Ligandfpr2-alx_on_gp fpr1-alx_on_gp
13.64Consensusmc4_on_gpOrthosteric Ligand7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2 7F58-MC4-THIQ-Gs/β1/γ2 7F54-MC4-Afamelanotide-Gs/β1/γ2 7F53-MC4-α-MSH-Gs/β1/γ2 7F55-MC4-Bremelanotide-Gs/β1/γ2
13.64Consensusmc5_onOrthosteric Ligand8INR-MC5-α-MSH-Ca-chim(NtGi1-Gs)/β1/γ2 8IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/β1/γ2
13.33Single4MBSMaraviroc4MBS-CCR5-Maraviroc
13.33Single6LRYSarafotoxin-B6LRY-ETB-Sarafotoxin-B
13.33Single6VI4JDTic6VI4-κ-JDTic
13.33Single6ZFZ77-LH-28-16ZFZ-M1-77-LH-28-1
13.33Single7BB6AVP7BB6-V2-AVP-Gs/β1/γ2
13.33Single7CKWFenoldopam7CKW-D1-Fenoldopam-Gs/β1/γ2
13.33Single7F61PF-036547467F61-H3-PF-03654746-Cholesterol
13.33Single7SR8TAK-9257SR8-OX2-TAK-925-chim(NtGi1L-Gs-CtGq)/β1/γ2
13.33Single7WVUfMLF7WVU-FPR1-ALX-fMLF-Gi1/β1/γ2
13.33Single8HQN9-S-HODE8HQN-GPR132-9-S-HODE-Gi1/β1/γ2
13.33Single8IHKAcifran8IHK-HCA3-Acifran
13.33Single8V6UPubChem 1713924568V6U-5-HT2A-PubChem 171392456-chim(NtGi2-Gs-CtGq)/β1/γ2
13.33Single8YKVPubChem 1375531688YKV-Succinate-PubChem 137553168-Gi1/β1/γ2
13.33Single8ZPMAMD0708ZPM-CXCR4-AMD070-Cholesterol
13.33Single9K1DButanoic acid9K1D-FFA2-Butanoic acid-Cholesterol-Gi1/β1/γ2
13.33Consensuscb1_offOrthosteric Ligand5U09-CB1-Taranabant 5TGZ-CB1-AM6538
13.33Consensusgrh_offOrthosteric Ligandgnrh1_off
13.33Consensusgs_peptideOrthosteric Ligandgs_cck gs_melanocortin gs_vasop-oxy
13.33Consensusnop_offOrthosteric Ligand4EA3-NOP-PubChem 10296561 5DHG-NOP-C-35 5DHH-NOP-SB-612111
13.33Consensusnucleotide_offOrthosteric Ligandadenosine_off p2y_off
13.04Single3OE0CVX153OE0-CXCR4-CVX15
13.04Single6LW5WKYMVm6LW5-FPR2-ALX-WKYMVm
13.04Single6W25SHU91196W25-MC4-SHU9119-Ca
13.04Single7F4DAlpha-MSH7F4D-MC1-α-MSH-chim(NtGi1-Gs)/β1/γ2
13.04Single7RYCOxytocin7RYC-OT-Oxytocin-chim(NtGi2L-Gs-CtGq)/β1/γ2
13.04Single7TD2LPA7TD2-LPA1-LPA-Gi1/β1/γ2
13.04Single8K6NPro-neuropeptide-Y8K6N-Y2-Pro-neuropeptide-Y-Gi2/β1/γ1
13.04Single8WKZSBL-MC-318WKZ-MC4-SBL-MC-31
13.04Single8XGUTAK4488XGU-Kiss1-TAK448-Gi1/β1/γ2
13.04Single8XIRPasireotide8XIR-SST3-Pasireotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
13.04Consensusangiotensin_onOrthosteric Ligandat1_on
13.04Consensusat1_onOrthosteric Ligand7F6G-AT1-SAR1-AngII-Gq/β1/γ2
13.04Consensuscompl-peptide_on_gpOrthosteric Ligandc5a1_on_gp c3a_on_gp
13.04Consensuscxcr4_on_gpOrthosteric Ligand8K3Z-CXCR4-CXCL12-Gi1/β1/γ1
13.04Consensusfpr2-alx_onOrthosteric Ligand7WVX-FPR2-ALX-Humanin-Gi2/β1/γ2 7T6U-FPR2-ALX-CGEN-855A-Gi1/β1/γ2 7T6V-FPR2-ALX-fMLFII-Gi1/β1/γ2 7WVY-FPR2-ALX-Amyloid-β42-Gi2/β1/γ2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/β1/γ2 6OMM-FPR2-ALX-WKYMVX-Gi1/β1/γ2
13.04Consensusgs_cckOrthosteric Ligand7MBX-CCKA-Cholecystokinin-8-Gs/β1/γ1
13.04Consensusmc3_onOrthosteric Ligand8IOC-MC3-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
13.04Consensusmc3_on_gpOrthosteric Ligand8IOC-MC3-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
13.04Consensuspeptide_offonOrthosteric Ligandpeptide_off peptide_on
12.90Single7TYYCalcitonin-17TYY-CT (AMY2)-Calcitonin-1-Gs/β1/γ2; RAMP2
12.50Single4EA3PubChem 102965614EA3-NOP-PubChem 10296561
12.50Single5DHGC-355DHG-NOP-C-35
12.50Single5DHHSB-6121115DHH-NOP-SB-612111
12.50Single5NDDAZ8838; Na5NDD-PAR2-AZ8838; Na
12.50Single5ZKPForopafant (SR27417)5ZKP-PAF-Foropafant (SR27417)
12.50Single6DRXLisuride6DRX-5-HT2B-Lisuride
12.50Single6GPSMK08126GPS-CCR2-MK0812
12.50Single6JODAngiotensin II6JOD-AT2-Angiotensin II
12.50Single6KPFPubChem 1459158896KPF-CB2-PubChem 145915889-Gi1/β1/γ2
12.50Single6WI9Secretin6WI9-Secretin-Secretin-Gs/β1/γ2
12.50Single7AD3Alpha-factor mating pheromone7AD3-STE2-α-factor mating pheromone-Gi1/STE4/γ2
12.50Single7F4HAfamelanotide7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2
12.50Single7F6GSAR1-AngII7F6G-AT1-SAR1-AngII-Gq/β1/γ2
12.50Single7FIHOrg435537FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/β1/γ2
12.50Single7JOZVFP7JOZ-D1-VFP-Gs/β1/γ2
12.50Single7PP1Selatogrel7PP1-P2Y12-Selatogrel
12.50Single7SQOTAK-9257SQO-OX2-TAK-925-Gi1/β1/γ2
12.50Single7V9MSomatoliberin7V9M-GHRH (SV1)-Somatoliberin-Gs/β1/γ2
12.50Single7VGZRemalteon7VGZ-MT1-Remalteon-Gi1/β1/γ2
12.50Single7VIFS-FTY720-P7VIF-S1P1-S-FTY720-P-Gi1/β1/γ2
12.50Single7VKTLTB47VKT-BLT1-LTB4-Gi1/β1/γ2
12.50Single7W40Bombesin7W40-BB2-Bombesin-chim(NtGi1L-Gq)/β1/γ2
12.50Single7YONPeptide-YY(3-36)7YON-Y2-Peptide-YY(3-36)-Gi1/β1/γ2
12.50Single7YXAONO-54306087YXA-S1P5-ONO-5430608
12.50Single8GCML9026888GCM-EP4-L902688-Gi1/β1/γ2
12.50Single8HA0PTH8HA0-PTH1-PTH-chim(NtGi1-Gs)/β1/γ2
12.50Single8IEDA1LYA8IED-GPR156-A1LYA-Go/β1/γ2
12.50Single8IHJAcifran8IHJ-HCA3-Acifran-Gi1/β1/γ2
12.50Single8KFYZK-7563268KFY-CCR8-ZK-756326-Gi1/β1/γ2
12.50Single8UWLLisuride8UWL-5-HT2A-Lisuride-chim(NtGi2-Gs-CtGq)/β1/γ2
12.50Single8XJLPGF2-alpha8XJL-FP-alpha-PGF2-α-chim(NtGi2-Gs-CtGq)/β1/γ2
12.50Single8YICSAR2477998YIC-S1P1-SAR247799-Gi1/β1/γ2
12.50Single8ZBEOctreotide8ZBE-SST5-Octreotide-Gi1/β1/γ1
12.50Single8ZQEGPR15L(C11)8ZQE-GPR15-GPR15L(C11)-Gi1/β1/γ1
12.50Consensus5ht6_onOrthosteric Ligand7XTB-5-HT6-Serotonin-Gs/β1/γ2 8JLZ-5-HT6-ST1936-Gs/β1/γ2
12.50Consensus5ht6_on_gpOrthosteric Ligand7XTB-5-HT6-Serotonin-Gs/β1/γ2 8JLZ-5-HT6-ST1936-Gs/β1/γ2
12.50Consensusalicarboxylic_offOrthosteric Ligandsuccinate_off
12.50Consensusangiotensin_on_gpOrthosteric Ligandat1_on_gp
12.50Consensusat1_on_gpOrthosteric Ligand7F6G-AT1-SAR1-AngII-Gq/β1/γ2
12.50Consensusblt1_onOrthosteric Ligand7VKT-BLT1-LTB4-Gi1/β1/γ2
12.50Consensusblt1_on_gpOrthosteric Ligand7VKT-BLT1-LTB4-Gi1/β1/γ2
12.50Consensusblt_onOrthosteric Ligandblt1_on
12.50Consensusblt_on_gpOrthosteric Ligandblt1_on_gp
12.50Consensuscck_offOrthosteric Ligandccka_off
12.50Consensusccka_offOrthosteric Ligand7F8Y-CCKA-Devazepide 7F8U-CCKA-Lintitript
12.50Consensusccr2_offOrthosteric Ligand6GPS-CCR2-MK0812
12.50Consensusfpr2-alx_on_gpOrthosteric Ligand7WVX-FPR2-ALX-Humanin-Gi2/β1/γ2 7T6U-FPR2-ALX-CGEN-855A-Gi1/β1/γ2 7T6V-FPR2-ALX-fMLFII-Gi1/β1/γ2 7WVY-FPR2-ALX-Amyloid-β42-Gi2/β1/γ2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/β1/γ2 6OMM-FPR2-ALX-WKYMVX-Gi1/β1/γ2
12.50Consensusgi_formylpeptideOrthosteric Ligand7WVY-FPR2-ALX-Amyloid-β42-Gi2/β1/γ2 7T6U-FPR2-ALX-CGEN-855A-Gi1/β1/γ2 7VFX-FPR1-ALX-fMLF-Gi1/β1/γ2 7T6V-FPR2-ALX-fMLFII-Gi1/β1/γ2 7WVX-FPR2-ALX-Humanin-Gi2/β1/γ2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/β1/γ2 6OMM-FPR2-ALX-WKYMVX-Gi1/β1/γ2
12.50Consensusgi_leukotrieneOrthosteric Ligand7VKT-BLT1-LTB4-Gi1/β1/γ2
12.50Consensusgi_orexinOrthosteric Ligand7SQO-OX2-TAK-925-Gi1/β1/γ2
12.50Consensusgq_angiotensinOrthosteric Ligand7F6G-AT1-SAR1-AngII-Gq/β1/γ2
12.50Consensusleukotriene_onOrthosteric Ligandblt_on
12.50Consensusleukotriene_on_gpOrthosteric Ligandblt_on_gp
12.50Consensusmc5_on_gpOrthosteric Ligand8INR-MC5-α-MSH-Ca-chim(NtGi1-Gs)/β1/γ2 8IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/β1/γ2
12.50Consensusnucleotide_offonOrthosteric Ligandnucleotide_off nucleotide_on
12.50Consensusnucleotide_offon_gpOrthosteric Ligandnucleotide_on_gp nucleotide_off
12.50Consensuspeptide_offon_gpOrthosteric Ligandpeptide_on_gp peptide_off
12.50Consensusprotein_offonOrthosteric Ligandprotein_off protein_on
12.50Consensusprotein_offon_gpOrthosteric Ligandprotein_on_gp protein_off
12.50Consensusprotein_onOrthosteric Ligandchemokine_on chemerin_on
12.50Consensussuccinate_offOrthosteric Ligand6RNK-Succinate-NF-56-EJ40 6Z10-Succinate-PubChem 154585554
12.00Single7QBIAlpha-factor mating pheromone7QBI-STE2-α-factor mating pheromone
12.00Single7TYHCalcitonin-17TYH-CT (AMY2)-Calcitonin-1-Gs/β1/γ2; RAMP2
12.00Single7WBJPACAP277WBJ-VPAC1-PACAP27-Gs/β1/γ2
12.00Single7Y64C5a anaphylatoxin7Y64-C5a1-C5a anaphylatoxin-Gi1/β1/γ2
12.00Single8HCXEndothelin-18HCX-ETB-Endothelin-1-chim(NtGi2L-Gs-CtGq)/β1/γ2
12.00Single8HK5Complement C58HK5-C5a1-Complement C5-Gi1/β1/γ2
12.00Single8IA2C5a anaphylatoxin8IA2-C5a1-C5a anaphylatoxin-Go/β1/γ2
12.00Single8IODPG-9018IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/β1/γ2
12.00Single8ZPSPrRP208ZPS-PrRP-PrRP20-chim(NtGi1-Gs-CtGq)/β1/γ2
12.00Consensuschemokine_on_gpOrthosteric Ligandccr_on_gp cxcr_on_gp
12.00Consensusgi_chemokineOrthosteric Ligand6WWZ-CCR6-CCL20-Go/β1/γ2 8HNK-CXCR3-CXCL11-Gi1/β1/γ2 8K3Z-CXCR4-CXCL12-Gi1/β1/γ1 8IC0-CXCR1-Interleukin-8-Gi1/β1/γ2 6LFM-CXCR2-Interleukin-8-Gi1/β1/γ2 8KFX-CCR8-LMD-009-Gi1/β1/γ2 7F1Q-CCR5-MIP-1a-Gi1/β1/γ2 8HNL-CXCR3-PS372424-Gi1/β1/γ2 8KFY-CCR8-ZK-756326-Gi1/β1/γ2 7O7F-CCR5-6P4-CCL5-Gi1/β1/γ1 8U1U-CCR8-CCL1-Gi1/β1/γ2 7VLA-CCR1-CCL15(27-92)-Gi1/β1/γ2 7XA3-CCR2-CCL2-Gi1/β1/γ2
12.00Consensusmc1_onOrthosteric Ligand7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2 7F4D-MC1-α-MSH-chim(NtGi1-Gs)/β1/γ2 7F4I-MC1-SHU9119-chim(NtGi1-Gs)/β1/γ2
12.00Consensusmc1_on_gpOrthosteric Ligand7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2 7F4D-MC1-α-MSH-chim(NtGi1-Gs)/β1/γ2 7F4I-MC1-SHU9119-chim(NtGi1-Gs)/β1/γ2
11.76Single4NTJAZD12834NTJ-P2Y12-AZD1283
11.76Single4PHUFasiglifam4PHU-FFA1-Fasiglifam
11.76Single4RWDDIPP-NH24RWD-δ-DIPP-NH2-Na
11.76Single5T1APubChem 68764898; PubChem 120931705T1A-CCR2-PubChem 68764898; PubChem 12093170
11.76Single5YHLPubChem 1351213525YHL-EP4-PubChem 135121352
11.76Single5YWYONO-AE3-2085YWY-EP4-ONO-AE3-208
11.76Single6GPXMK08126GPX-CCR2-MK0812
11.76Single6M9TMisoprostol-FA6M9T-EP3-Misoprostol-FA
11.76Single6Z4QSR142948A6Z4Q-NTS1-SR142948A
11.76Single7BB7AVP7BB7-V2-AVP-Gs/β1/γ2
11.76Single7C4SS1P7C4S-S1P3-S1P
11.76Single7VFXfMLF7VFX-FPR1-ALX-fMLF-Gi1/β1/γ2
11.76Single7VV0PAMP-127VV0-MRGPRX2-PAMP-12
11.76Single7VV4Cortistatin-147VV4-MRGPRX2-Cortistatin-14
11.76Single8EJCTAK-8758EJC-FFA1-TAK-875-chim(NtGi1L-Gs-CtGq)/β1/γ2
11.76Single8GD9Rivenprost8GD9-EP4-Rivenprost-Gs/β1/γ2
11.76Single8JXSPF-61428JXS-D1-PF-6142
11.76Single8KFXLMD-0098KFX-CCR8-LMD-009-Gi1/β1/γ2
11.76Single8X0BVU04244658X0B-mGlu5; mGlu5-Quisqualate-VU0424465
11.76Single8X0CVU04244658X0C-mGlu5; mGlu5-Quisqualate-VU0424465
11.76Single8XQPCholesterol8XQP-TAS2R14-Cholesterol-Aristolochic acid A-Gt3/β1/γ1
11.76Consensusep4_offOrthosteric Ligand5YWY-EP4-ONO-AE3-208 5YHL-EP4-PubChem 135121352
11.76Consensusep_offOrthosteric Ligandep4_off
11.76Consensusfpr1-alx_onOrthosteric Ligand7VFX-FPR1-ALX-fMLF-Gi1/β1/γ2
11.76Consensusfpr1-alx_on_gpOrthosteric Ligand7VFX-FPR1-ALX-fMLF-Gi1/β1/γ2
11.76Consensuss1p5_offOrthosteric Ligand7YXA-S1P5-ONO-5430608
11.54Single5UIW5P7-CCL55UIW-CCR5-5P7-CCL5
11.54Single6NBFLong-Acting PTH Analog6NBF-PTH1-Long-Acting PTH Analog-Gs/β1/γ2
11.54Single6P9YPACAP6P9Y-PAC1-PACAP-Gs/β1/γ2
11.54Single7F8VGastrin-177F8V-CCKB-Gastrin-17-Gi2/β1/γ2
11.54Single7QBIAlpha-factor mating pheromone7QBI-STE2-α-factor mating pheromone
11.54Consensusccr5_offOrthosteric Ligand5UIW-CCR5-5P7-CCL5
11.54Consensusccr5_onOrthosteric Ligand7O7F-CCR5-6P4-CCL5-Gi1/β1/γ1 7F1Q-CCR5-MIP-1a-Gi1/β1/γ2
11.54Consensusgi_compl-peptOrthosteric Ligand8HK5-C5a1-Complement C5-Gi1/β1/γ2 8IA8-C3aB-E7 peptide-Gi1/β1/γ2 7Y66-C5a1-BM213-Gi1/β1/γ2 7Y67-C5a1-C089 peptide-Gi1/β1/γ2 8HK2-C3aB-C3a anaphylatoxin-Gi1/β1/γ2 7Y64-C5a1-C5a anaphylatoxin-Gi1/β1/γ2
11.54Consensusgi_peptideOrthosteric Ligandgi_cck gi_apelin gi_compl-pept gi_endothelin gi_formylpeptide gi_galanin gi_ghrelin gi_npy gi_neurotensin gi_opioid gi_orexin gi_relaxin gi_somatostatin
11.54Consensusgi_proteinOrthosteric Ligandgi_chemokine gi_chemerin
11.54Consensusprotein_on_gpOrthosteric Ligandchemokine_on_gp chemerin_on_gp
11.11Single5TZRMK86665TZR-FFA1-MK8666
11.11Single6B3JExendin-P56B3J-GLP-1-Exendin-P5-Gs/β1/γ2
11.11Single6N4BMDMB-Fubinaca6N4B-CB1-MDMB-Fubinaca-Gi1/β1/γ2
11.11Single6UVAAdrenomedullin-26UVA-CT Like (AM2)-Adrenomedullin-2-Gs/β1/γ2; RAMP3
11.11Single7AD3Alpha-factor mating pheromone7AD3-STE2-α-factor mating pheromone-Gi1/STE4/γ2
11.11Single7F4FAfamelanotide7F4F-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2
11.11Single7P2L4YI7P2L-mGlu5-4YI
11.11Single7QBCAlpha-factor mating pheromone7QBC-STE2-α-factor mating pheromone
11.11Single7S8MCortistatin-147S8M-MRGPRX2-Cortistatin-14-Gi1/β1/γ2
11.11Single7T9NPubChem 6440787T9N-TSH-M22 Fab-PubChem 644078-Gs/β1/γ2
11.11Single7VIGCBP-3077VIG-S1P1-CBP-307-Gi1/β1/γ2
11.11Single7WVXHumanin7WVX-FPR2-ALX-Humanin-Gi2/β1/γ2
11.11Single7YOONeuropeptide-Y7YOO-Y2-Neuropeptide-Y-Gi1/β1/γ2
11.11Single8GDBPGE28GDB-EP4-PGE2-Gs/β1/γ2
11.11Single8HAOPTH8HAO-PTH1-PTH-chim(NtGi1-Gs)/β1/γ2
11.11Single8HPTC5a anaphylatoxin C-terminal peptide8HPT-C5a1-C5a anaphylatoxin C-terminal peptide-Go/β1/γ2
11.11Single8I2GCompound 7163408I2G-FSH-Glycoprotein hormones α chain-Compound 716340-Gs/β1/γ2
11.11Single8I9LC3a anaphylatoxin8I9L-C3aB-C3a anaphylatoxin-Go/β1/γ2
11.11Single8IUKPGF2-alpha8IUK-FP-alpha-PGF2-α-chim(NtGi1-Gs-CtGq)/β1/γ2
11.11Single8JBGNeurokinin-B8JBG-NK3-Neurokinin-B-chim(NtGi1-Gs-CtGq)/β1/γ2
11.11Single8JLPRalmitaront8JLP-TA1-Ralmitaront-Gs/β1/γ2
11.11Single8JSRAnamorelin8JSR-Ghrelin-Anamorelin-chim(NtGi1-Gs-CtGq)/β1/γ2
11.11Single8JZPC5A anaphylatoxin8JZP-C5a1-C5A anaphylatoxin-Go/β1/γ2
11.11Single8X0BVU04244658X0B-mGlu5; mGlu5-Quisqualate-VU0424465
11.11Single8X79MRE-2698X79-I2-MRE-269-Gs/β1/γ2
11.11Single8XQTCholesterol8XQT-TAS2R14-Cholesterol-Cholesterol-Gi1/β1/γ1
11.11Single9ASTLymphotactin9AST-XCR1-Lymphotactin-Gi1/β1/γ2
11.11Single9B65KCA9B65-CB1-KCA-Gi1/β1/γ2
11.11Single9BJKNAM9BJK-μ-Naloxone-NAM
11.11Consensusffa_onOrthosteric Ligandffa2_on ffa3_on
11.11Consensusffa_on_gpOrthosteric Ligandffa2_on_gp ffa3_on_gp
11.11Consensusgi_ffaOrthosteric Ligand8J21-FFA3-Butyric acid-Gi1/β1/γ2 8J22-FFA2-TUG-1375-Gi1/β1/γ2
11.11Consensusnpy2_onOrthosteric Ligand7YOO-Y2-Neuropeptide-Y-Gi1/β1/γ2
11.11Consensusnpy2_on_gpOrthosteric Ligand7YOO-Y2-Neuropeptide-Y-Gi1/β1/γ2
11.11Consensusnpy_offOrthosteric Ligandnpy1_off npy2_off
11.11Consensuspeptide_onOrthosteric Ligandcck_on angiotensin_on apelin_on bombesin_on bradykinin_on compl-peptide_on endothelin_on formylpeptide_on galanin_on ghrelin_on kisspeptin_on melanocortin_on motilin_on neuromedin-u_on npy_on neurotensin_on opioid_on orexin_on relaxin_on somatostatin_on tachykinin_on trh_on vasop-oxy_on
11.11Consensuspeptide_on_gpOrthosteric Ligandcck_on_gp angiotensin_on_gp apelin_on_gp bombesin_on_gp bradykinin_on_gp compl-peptide_on_gp endothelin_on_gp formylpeptide_on_gp galanin_on_gp ghrelin_on_gp kisspeptin_on_gp melanocortin_on_gp motilin_on_gp neuromedin-u_on_gp npy_on_gp neurotensin_on_gp opioid_on_gp orexin_on_gp relaxin_on_gp somatostatin_on_gp tachykinin_on_gp trh_on_gp vasop-oxy_on_gp
10.71Single5VAIGLP-15VAI-GLP-1-GLP-1-Gs/β1/γ2
10.71Single6IGLIRL16206IGL-ETB-IRL1620
10.71Single6LMKGlucagon6LMK-Glucagon-Glucagon-Gs/β1/γ2
10.71Single6LMLGlucagon6LML-Glucagon-Glucagon-Gi1/β1/γ1
10.71Single7KI1Taspoglutide7KI1-GLP-1-Taspoglutide-Gs/β1/γ2
10.71Single7QBCAlpha-factor mating pheromone7QBC-STE2-α-factor mating pheromone
10.71Single7TS0Urocortin7TS0-CRF2-Urocortin-chim(NtGi1L-Go)/β1/γ2
10.71Single7TYLAmylin7TYL-CT-Amylin-Gs/β1/γ2
10.71Single7VGXNeuropeptide-Y7VGX-Y1-Neuropeptide-Y-Gi1/β1/γ2
10.71Single8F0KPramlintide Analogue San3858F0K-CT (AMY3)-Pramlintide Analogue San385-Gs/β1/γ2; RAMP3
10.71Single8IY6Endothelin-18IY6-ETB-Endothelin-1
10.71Consensusendothelin_onOrthosteric Ligandetb_on eta_on
10.71Consensusetb_onOrthosteric Ligand8IY5-ETB-Endothelin-1-Gi1/β1/γ2 8HBD-ETB-IRL1620-Gi1/β1/γ2
10.71Consensusgs_melanocortinOrthosteric Ligand7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2 7F54-MC4-Afamelanotide-Gs/β1/γ2 7F4D-MC1-α-MSH-chim(NtGi1-Gs)/β1/γ2 8INR-MC5-α-MSH-Ca-chim(NtGi1-Gs)/β1/γ2 7F53-MC4-α-MSH-Gs/β1/γ2 7F55-MC4-Bremelanotide-Gs/β1/γ2 8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1 8IOC-MC3-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2 8IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/β1/γ2 7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2 7F4I-MC1-SHU9119-chim(NtGi1-Gs)/β1/γ2 7F58-MC4-THIQ-Gs/β1/γ2
10.53Single5TZYMK8666; PubChem 1270535975TZY-FFA1-MK8666; PubChem 127053597
10.53Single6C1RPMX536C1R-C5a1-PMX53-Avacopan; Na
10.53Single7EO4BAF3127EO4-S1P1-BAF312-Gi1/β1/γ2
10.53Single7L0SNeurotensin7L0S-NTS1-Neurotensin-Gi1/β1/γ1
10.53Single7L1UOrexin7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/β1/γ2
10.53Single7L1VPubChem 1554910097L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/β1/γ2
10.53Single7T6BS1P7T6B-S1P2-S1P-chim(NtGi1L-G13)/β1/γ2
10.53Single7Y66BM2137Y66-C5a1-BM213-Gi1/β1/γ2
10.53Single8GCPPGE28GCP-EP4-PGE2-Gi1/β1/γ2
10.53Single8H0QGastrin Releasing Peptide8H0Q-BB2-Gastrin Releasing Peptide-chim(NtGi1-Gs-CtGq)/β1/γ2
10.53Single8HK2C3a anaphylatoxin8HK2-C3aB-C3a anaphylatoxin-Gi1/β1/γ2
10.53Single8J6DEP1418J6D-C3aB-EP141-Go/β1/γ2
10.53Single8W1VPubChem 1717162658W1V-β2-PubChem 171716265
10.53Single8XQNCholesterol8XQN-TAS2R14-Cholesterol-Aristolochic acid A-Gi1/β1/γ1
10.53Single8XQSCholesterol8XQS-TAS2R14-Cholesterol-Flufenamic acid-Gi1/β1/γ1
10.53Single9IZHLPA9IZH-LPA1-LPA-chim(NtGi2-G13)/β1/γ2
10.53Single9L3WRetinoic acid receptor responder protein 29L3W-CML1-Retinoic acid receptor responder protein 2-Gi1/β1/γ2
10.53Consensusccr8_onOrthosteric Ligand8KFX-CCR8-LMD-009-Gi1/β1/γ2 8KFY-CCR8-ZK-756326-Gi1/β1/γ2 8U1U-CCR8-CCL1-Gi1/β1/γ2
10.53Consensuscxcr_onOrthosteric Ligandcxcr3_on cxcr4_on cxcr1_on cxcr2_on
10.53Consensusgi_lipidOrthosteric Ligandgi_cannabinoid gi_ffa gi_leukotriene gi_lpa gi_s1p
10.53Consensuskop_onOrthosteric Ligand8F7W-κ-Dynorphin-Gi1/β1/γ2 8DZS-κ-GR89,696-chim(NtGi2-Gz)/β1/γ2 8DZP-κ-momSalB-Gi1/β1/γ2
10.53Consensusorexin_onOrthosteric Ligandox2_on
10.53Consensuss1p3_onOrthosteric Ligand7EW3-S1P3-S1P-Gi1/β1/γ2 7EW4-S1P3-CYM5541-Gi1/β1/γ2 7EW2-S1P3-Fingolimod-Gi1/β1/γ2
10.34Single7DUQGLP-17DUQ-GLP-1-GLP-1-PubChem 156022738-Gs/β1/γ2
10.34Single7TYXAmylin7TYX-CT (AMY2)-Amylin-Gs/β1/γ2; RAMP2
10.34Consensusgi_endothelinOrthosteric Ligand8IY5-ETB-Endothelin-1-Gi1/β1/γ2 8HBD-ETB-IRL1620-Gi1/β1/γ2
10.34Consensusgi_npyOrthosteric Ligand8K6M-Y1-Neuropeptide-Y-Gi2/β1/γ1 7X9C-Y4-Pancreatic Hormone-Gi1/β1/γ2 7YOO-Y2-Neuropeptide-Y-Gi1/β1/γ2
10.34Consensusnpy_onOrthosteric Ligandnpy1_on npy2_on npy4_on
10.34Consensusnpy_on_gpOrthosteric Ligandnpy1_on_gp npy2_on_gp npy4_on_gp
10.00Single6DDFDamgo6DDF-μ-Damgo-Gi1/β1/γ2
10.00Single6K1QIRL25006K1Q-ETB-IRL2500
10.00Single7CX4Evatanepag7CX4-EP2-Evatanepag-Gs/β1/γ2
10.00Single7LLLExendin-47LLL-GLP-1-Exendin-4-Gs/β1/γ2
10.00Single7MBYCholecystokinin-87MBY-CCKA-Cholecystokinin-8-chim(NtGi1L-Gs-CtGq)/β1/γ2
10.00Single7VVNPTH7VVN-PTH1-PTH-Gs/β1/γ2
10.00Single7X8RBOC57X8R-GLP-1-BOC5-Gs/β1/γ2
10.00Single7YU8ONO-07405567YU8-LPA1-ONO-0740556-Gi1/β1/γ2
10.00Single8F2APramlintide Analogue San3858F2A-CT (AMY3)-Pramlintide Analogue San385-Gs/β1/γ2; RAMP3
10.00Single8FLSAbaloparatide8FLS-PTH1-Abaloparatide-Gs/β1/γ2
10.00Single8FLULong-Acting PTH8FLU-PTH1-Long-Acting PTH-Gs/β1/γ2
10.00Single8GAGPubChem 1708384908GAG-CB1-PubChem 170838490-Gi1/β1/γ2
10.00Single8HBDIRL16208HBD-ETB-IRL1620-Gi1/β1/γ2
10.00Single8HN1Toxin AdTx18HN1-Alpha1A-Toxin AdTx1
10.00Single8WRZPubChem 1023367048WRZ-CB1-PubChem 102336704-Arrestin2
10.00Single8XGSMetastin8XGS-Kiss1-Metastin-chim(NtGi1-Gq)/β1/γ2
10.00Single9AUCCalcitonin gene-related peptide-19AUC-CT-Calcitonin gene-related peptide-1-Gs/β1/γ2; RAMP1
10.00Single9IZFNKP9IZF-LPA1-NKP-Gi1/β1/γ2
10.00Consensuscck_onOrthosteric Ligandccka_on cckb_on
10.00Consensuscck_on_gpOrthosteric Ligandccka_on_gp cckb_on_gp
10.00Consensusendothelin_on_gpOrthosteric Ligandetb_on_gp eta_on_gp
10.00Consensusetb_on_gpOrthosteric Ligand8IY5-ETB-Endothelin-1-Gi1/β1/γ2 8HBD-ETB-IRL1620-Gi1/β1/γ2
10.00Consensusmelanocortin_onOrthosteric Ligandmc1_on mc4_on mc2_on mc3_on mc5_on
10.00Consensusmelanocortin_on_gpOrthosteric Ligandmc1_on_gp mc4_on_gp mc2_on_gp mc3_on_gp mc5_on_gp
10.00Consensusorexin_on_gpOrthosteric Ligandox2_on_gp
9.68Single6WPWGlucagon derivative ZP37806WPW-Glucagon-Glucagon derivative ZP3780-Gs/β1/γ2
9.68Single7VVMPTH7VVM-PTH1-PTH-Gs/β1/γ2
9.52Single5VBLApelin mimetic peptide agonist5VBL-Apelin-Apelin mimetic peptide agonist
9.52Single6C1QPMX536C1Q-C5a1-PMX53-NDT9513727
9.52Single6OMMWKYMVX6OMM-FPR2-ALX-WKYMVX-Gi1/β1/γ2
9.52Single7AUESetmelanotide7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2
9.52Single7CX2PGE27CX2-EP2-PGE2-Gs/β1/γ2
9.52Single7RKFFractalkine7RKF-US28-Fractalkine-GDP-chim(NtGi1-G11)/β1/γ2
9.52Single7RKNFractalkine7RKN-US28-Fractalkine-Gi1/β1/γ2
9.52Single7S8LCortistatin-147S8L-MRGPRX2-Cortistatin-14-chim(NtGi2L-Gs-CtGq)/β1/γ2
9.52Single7XBXCX3CL17XBX-CX3CR1-CX3CL1-Gi1/β1/γ2
9.52Single7YJ4INSL57YJ4-RXFP4-INSL5-Gi2/β1/γ2
9.52Single8GDAL9026888GDA-EP4-L902688-Gs/β1/γ2
9.52Single8IQ4Carboprost8IQ4-FP-alpha-Carboprost-chim(NtGi1-Gs-CtGq)/β1/γ2
9.52Single8X3LXWD8X3L-CB2-XWD-Gi1/β1/γ2
9.52Single8XQLCholesterol8XQL-TAS2R14-Cholesterol-Aristolochic acid A-Gt3/β1/γ1
9.52Single8XQOCholesterol8XQO-TAS2R14-Cholesterol-Aristolochic acid A-Gi1/β1/γ1
9.52Single8Z74Agonistic antibody8Z74-Apelin-Agonistic antibody
9.52Single9ERXD9-THC analog9ERX-CB1-D9-THC analog-Gi1/β1/γ2
9.52Consensusdop_onOrthosteric Ligand8F7S-δ-Deltorphin-Gi1/β1/γ2
9.52Consensusgq_cckOrthosteric Ligand8IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/β1/γ2 7XOW-CCKB-Gastrin-chim(NtGi1-Gq)/β1/γ2 7EZM-CCKA-Cholecystokinin-8-chim(NtGsL-Gq)/β1/γ2 7F8W-CCKB-Gastrin-17-chim(NtGsL-Gq)/β1/γ2
9.52Consensusnmur1_onOrthosteric Ligand7W53-NMUR1-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
9.52Consensusox2_onOrthosteric Ligand7L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/β1/γ2 7SQO-OX2-TAK-925-Gi1/β1/γ2 7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/β1/γ2
9.52Consensusox2_on_gpOrthosteric Ligand7L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/β1/γ2 7SQO-OX2-TAK-925-Gi1/β1/γ2 7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/β1/γ2
9.38Single7TYOCalcitonin7TYO-CT-Calcitonin-Gs/β1/γ2
9.38Single7X9ANeuropeptide-Y7X9A-Y1-Neuropeptide-Y-Gi1/β1/γ2
9.38Single7Y36Teriparatide7Y36-PTH1-Teriparatide-Gs/β1/γ2
9.38Single8FLQPTH8FLQ-PTH1-PTH-Gs/β1/γ2
9.09Single4XT1Fractalkine4XT1-US28-Fractalkine
9.09Single6E3YCalcitonin gene-related peptide-16E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/β1/γ2; RAMP1
9.09Single6X19CHU-1286X19-GLP-1-CHU-128-Gs/β1/γ2
9.09Single7CX3Taprenepag7CX3-EP2-Taprenepag-Gs/β1/γ2
9.09Single7F4ISHU91197F4I-MC1-SHU9119-chim(NtGi1-Gs)/β1/γ2
9.09Single7L0RNeurotensin7L0R-NTS1-Neurotensin-Gi1/β1/γ1
9.09Single7TD4Siponimod7TD4-S1P1-Siponimod-Gi1/β1/γ2
9.09Single7W2ZGhrelin7W2Z-Ghrelin-Ghrelin-Go/β1/γ2
9.09Single7W56Neuromedin-S7W56-NMUR1-Neuromedin-S-chim(NtGi1-Gs-CtGq)/β1/γ2
9.09Single7XMRSomatostatin-147XMR-SST2-Somatostatin-14-Gi1/β1/γ2
9.09Single8HQMNPGLY8HQM-GPR132-NPGLY-Gi1/β1/γ2
9.09Single8HVINOX-6-78HVI-GPR132-NOX-6-7-Gi1/β1/γ2
9.09Single8IEIA1LYA8IEI-GPR156-A1LYA
9.09Single8INRAlpha-MSH8INR-MC5-α-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
9.09Single8JIQPeptide-158JIQ-Glucagon-Peptide-15-Gs/β1/γ2
9.09Single8U4OCXCL128U4O-CXCR4-CXCL12-Cholesterol-Gi1/β1/γ2
9.09Single8XGMChemerin8XGM-CML2-Chemerin-Gi1/β1/γ2
9.09Single9BKJCholecystokinin-89BKJ-CCKA-Cholecystokinin-8-chim(NtGi1-Gs-CtGq)/β1/γ2
9.09Consensussomatostatin_offOrthosteric Ligandsst2_off
8.70Single7C6A(Sar1,Ile8)-Angiotensin II7C6A-AT2-(Sar1,Ile8)-Angiotensin II
8.70Single7DDZJNJ-310200287DDZ-Y2-JNJ-31020028
8.70Single7E14Orforglipron7E14-GLP-1-Orforglipron-PubChem 156022738-Gs/β1/γ2
8.70Single7F1QMIP-1a7F1Q-CCR5-MIP-1a-Gi1/β1/γ2
8.70Single7RMISubstance-P7RMI-NK1-Substance-P-chim(Gs-CtGq)/β1/γ2
8.70Single7SK5CXCL127SK5-ACKR3-CXCL12
8.70Single7XNACYN1548067XNA-SST2-CYN154806
8.70Single8F7SDeltorphin8F7S-δ-Deltorphin-Gi1/β1/γ2
8.70Single8F7WDynorphin8F7W-κ-Dynorphin-Gi1/β1/γ2
8.70Single8WSSPro-MCH8WSS-MCH1-Pro-MCH-Gi1/β1/γ1
8.70Single8XYDPlatelet Activating Factor8XYD-PAF-Platelet Activating Factor-Gi1/β1/γ2
8.70Single9EAINanobody AT2099EAI-AT1-Losartan-Nanobody AT209
8.70Consensuscckb_onOrthosteric Ligand8IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/β1/γ2 7XOW-CCKB-Gastrin-chim(NtGi1-Gq)/β1/γ2 7F8V-CCKB-Gastrin-17-Gi2/β1/γ2
8.70Consensusccr8_on_gpOrthosteric Ligand8KFX-CCR8-LMD-009-Gi1/β1/γ2 8KFY-CCR8-ZK-756326-Gi1/β1/γ2 8U1U-CCR8-CCL1-Gi1/β1/γ2
8.70Consensusdop_on_gpOrthosteric Ligand8F7S-δ-Deltorphin-Gi1/β1/γ2
8.70Consensusghrelin_onOrthosteric Ligand7NA7-Ghrelin-Ghrelin-27-Gi1/β1/γ2 7F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/β1/γ2 7NA8-Ghrelin-PubChem 178024-Gi1/β1/γ2
8.70Consensusghrelin_on_gpOrthosteric Ligand7NA7-Ghrelin-Ghrelin-27-Gi1/β1/γ2 7F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/β1/γ2 7NA8-Ghrelin-PubChem 178024-Gi1/β1/γ2
8.70Consensusgi_cckOrthosteric Ligand7EZH-CCKA-Cholecystokinin-8-Gi1/β1/γ2 7F8V-CCKB-Gastrin-17-Gi2/β1/γ2
8.70Consensusgi_ghrelinOrthosteric Ligand7NA7-Ghrelin-Ghrelin-27-Gi1/β1/γ2 7NA8-Ghrelin-PubChem 178024-Gi1/β1/γ2
8.70Consensusnpy2_offOrthosteric Ligand7DDZ-Y2-JNJ-31020028
8.70Consensussst2_offOrthosteric Ligand7XNA-SST2-CYN154806
8.57Single7F16TIP397F16-PTH2-TIP39-Gs/β1/γ2
8.33Single3OE8IT1t3OE8-CXCR4-IT1t
8.33Single6MEOEnvelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd46MEO-CCR5-Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4
8.33Single6TQ9SB-4081246TQ9-OX1-SB-408124
8.33Single6UUNAdrenomedullin6UUN-CT Like (AM1)-Adrenomedullin-Gs/β1/γ2; RAMP2
8.33Single6VN7PACAP6VN7-VPAC1-PACAP-Gs/β1/γ2
8.33Single7MBXCholecystokinin-87MBX-CCKA-Cholecystokinin-8-Gs/β1/γ1
8.33Single7O7F6P4-CCL57O7F-CCR5-6P4-CCL5-Gi1/β1/γ1
8.33Single7TD0LPA7TD0-LPA1-LPA-Gi1/β1/γ2
8.33Single7XA3CCL27XA3-CCR2-CCL2-Gi1/β1/γ2
8.33Single7XOUCholecystokinin-87XOU-CCKA-Cholecystokinin-8-Gs/β1/γ2
8.33Single8K6MNeuropeptide-Y8K6M-Y1-Neuropeptide-Y-Gi2/β1/γ1
8.33Single9K27PrRP319K27-PrRP-PrRP31-chim(NtGi1-Gq)/β1/γ2
8.33Consensusc5a1_onOrthosteric Ligand8HK5-C5a1-Complement C5-Gi1/β1/γ2 7Y66-C5a1-BM213-Gi1/β1/γ2 7Y67-C5a1-C089 peptide-Gi1/β1/γ2 7Y64-C5a1-C5a anaphylatoxin-Gi1/β1/γ2
8.33Consensuscckb_on_gpOrthosteric Ligand8IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/β1/γ2 7XOW-CCKB-Gastrin-chim(NtGi1-Gq)/β1/γ2 7F8V-CCKB-Gastrin-17-Gi2/β1/γ2
8.33Consensusccr2_onOrthosteric Ligand7XA3-CCR2-CCL2-Gi1/β1/γ2
8.33Consensusccr2_on_gpOrthosteric Ligand7XA3-CCR2-CCL2-Gi1/β1/γ2
8.33Consensusccr_onOrthosteric Ligandccr6_on ccr8_on ccr2_on ccr1_on ccr5_on
8.33Consensusnpy1_onOrthosteric Ligand8K6M-Y1-Neuropeptide-Y-Gi2/β1/γ1
8.33Consensusnpy1_on_gpOrthosteric Ligand8K6M-Y1-Neuropeptide-Y-Gi2/β1/γ1
8.00Single6M1IPACAP6M1I-PAC1-PACAP-Gs/β1/γ2
8.00Single6METEnvelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd46MET-CCR5-Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4
8.00Single7FIMTirzepatide7FIM-GLP-1-Tirzepatide-Gs/β1/γ2
8.00Single7KH0AVP7KH0-V2-AVP-chim(NtGi1-Gs)/β1/γ2
8.00Single7TYIAmylin7TYI-CT-Amylin-Gs/β1/γ2
8.00Single7W57Neuromedin-S7W57-NMUR2-Neuromedin-S-chim(NtGi1-Gs-CtGq)/β1/γ2
8.00Single7XK8Neuromedin-U-257XK8-NMUR2-Neuromedin-U-25-Gi1/β1/γ2
8.00Single8XWQEndothelin-18XWQ-ETB-Endothelin-1-Gi1/β1/γ2
8.00Single8XZJWN3538XZJ-Apelin-WN353-Gi1/β1/γ2
8.00Single8YW5Retatrutide8YW5-Glucagon-Retatrutide-Gs/β1/γ2
8.00Consensusc5a1_on_gpOrthosteric Ligand8HK5-C5a1-Complement C5-Gi1/β1/γ2 7Y66-C5a1-BM213-Gi1/β1/γ2 7Y67-C5a1-C089 peptide-Gi1/β1/γ2 7Y64-C5a1-C5a anaphylatoxin-Gi1/β1/γ2
7.69Single3OE6IT1t3OE6-CXCR4-IT1t
7.69Single6D32Cyclopamine6D32-SMO-Cyclopamine-Cyclopamine
7.69Single6PWCNeurotensin6PWC-NTS1-Neurotensin-Arrestin2
7.69Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
7.69Single7P02Protachykinin-17P02-NK1-Protachykinin-1-chim(NtGi1-Gs)/β1/γ2
7.69Single7V6APubChem 98642757V6A-M4-PubChem 9864275-Gi1/β1/γ2
7.69Single7VL9CCL15(26-92)7VL9-CCR1-CCL15(26-92)-Gi1/β1/γ2
7.69Single7X9BNeuropeptide-Y7X9B-Y2-Neuropeptide-Y-Gi1/β1/γ2
7.69Single7X9CPancreatic Hormone7X9C-Y4-Pancreatic Hormone-Gi1/β1/γ2
7.69Single7XV3Lysophosphatidylserine7XV3-GPR174-Lysophosphatidylserine-chim(NtGi1-Gs)/β1/γ2
7.69Single7Y35Abaloparatide7Y35-PTH1-Abaloparatide-Gs/β1/γ2
7.69Single8E3YPACAP278E3Y-VPAC1-PACAP27-Gs/β1/γ2
7.69Single8E3ZVIP8E3Z-VPAC1-VIP-Gs/β1/γ2
7.69Single8HCQEndothelin-18HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/β1/γ2
7.69Single8RQLFlufenamic acid8RQL-TAS2R14-Flufenamic acid-Flufenamic acid-chim(NtGi1-Gt3)/β1/γ2
7.69Single8XVHEndothelin-18XVH-ETB-Endothelin-1-chim(Gs-CtGq)/β1/γ2
7.69Single8XVIEndothelin-18XVI-ETA-Endothelin-1-chim(Gs-CtGq)/β1/γ2
7.69Single8ZPLCholesterol8ZPL-CXCR4-HF51116-Cholesterol
7.69Single8ZPMCholesterol8ZPM-CXCR4-AMD070-Cholesterol
7.69Single8ZRTET-18ZRT-ETB-ET-1
7.69Single9IV15alpha-DHT9IV1-ADGRD1-5α-DHT-chim(NtGi1-Gs)/β1/γ2
7.69Consensusccr_on_gpOrthosteric Ligandccr6_on_gp ccr8_on_gp ccr2_on_gp ccr1_on_gp ccr5_on_gp
7.69Consensuseta_onOrthosteric Ligand8HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/β1/γ2
7.69Consensuseta_on_gpOrthosteric Ligand8HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/β1/γ2
7.69Consensusneuromedin-u_on_gpOrthosteric Ligandnmur1_on_gp nmur2_on_gp
7.41Single4XT3Fractalkine4XT3-US28-Fractalkine
7.41Single6FJ3PTH6FJ3-PTH1-PTH
7.41Single6NBILong-Acting PTH Analog6NBI-PTH1-Long-Acting PTH Analog-Gs/β1/γ2
7.41Single7CZ5Somatoliberin7CZ5-GHRH-Somatoliberin-Gs/β1/γ2
7.41Single7KI0Semaglutide7KI0-GLP-1-Semaglutide-Gs/β1/γ2
7.41Single7RGPTirzepatide7RGP-GLP-1-Tirzepatide-chim(NtGi1-Gs)/β1/γ2
7.41Single7VABNon-Acylated Tirzepatide7VAB-GIP-Non-Acylated Tirzepatide-chim(NtGi1-Gs)/β1/γ2
7.41Single8E3XPACAP278E3X-PAC1-PACAP27-Gs/β1/γ2
7.41Single8XVEBQ30208XVE-ETB-BQ3020-chim(Gs-CtGq)/β1/γ2
7.41Single9J1Pg1:Ox9J1P-GLP-1-g1:Ox-chim(NtGi1-Gs)/β1/γ2
7.41Consensusnpy4_onOrthosteric Ligand7X9C-Y4-Pancreatic Hormone-Gi1/β1/γ2
7.41Consensusnpy4_on_gpOrthosteric Ligand7X9C-Y4-Pancreatic Hormone-Gi1/β1/γ2
7.14Single5L7IVismodegib5L7I-SMO-Vismodegib
7.14Single6VCBGLP-16VCB-GLP-1-GLP-1-LSN3160440-Gs/β1/γ2
7.14Single7F53Alpha-MSH7F53-MC4-α-MSH-Gs/β1/γ2
7.14Single7S1MEx4-D-Ala7S1M-GLP-1-Ex4-D-Ala-Gs/β1/γ2
7.14Single7S8NR-Zinc-35737S8N-MRGPRX2-R-Zinc-3573-chim(NtGi2L-Gs-CtGq)/β1/γ2
7.14Single7S8OR-Zinc-35737S8O-MRGPRX2-R-Zinc-3573-Gi1/β1/γ2
7.14Single7UL2SR486927UL2-NTS1-SR48692-Na
7.14Single7VDHC48/807VDH-MRGPRX2-C48/80-Gi1/β1/γ2
7.14Single7VUIJNJ-635330547VUI-GPR139-JNJ-63533054-GTP-chim(Gs-CtGq)/β1/γ2
7.14Single7VVKPTH7VVK-PTH1-PTH-Gs/β1/γ2
7.14Single7XP6Strychnine7XP6-T2R46-Strychnine-chim(Gs-CtGt3)/β1/γ2
7.14Single8HNNSCH5467388HNN-CXCR3-SCH546738
7.14Single8U4RREGN7663-Fab8U4R-CXCR4-REGN7663-Fab-Cholesterol
7.14Single8XWPEndothelin-18XWP-ETB-Endothelin-1-Gi1/β1/γ2
7.14Single8ZX5AM2518ZX5-GPR55-AM251-chim(NtGi1-G13)/β1/γ2
7.14Single9J5VCpY9J5V-LPA1-CpY-Gi1/β1/γ2
7.14Single9K26PrRP319K26-PrRP-PrRP31-Gi1/β1/γ2
7.14Consensusgq_nucleotideOrthosteric Ligandgq_p2y
7.14Consensusgq_p2yOrthosteric Ligand7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/β1/γ2
7.14Consensusneurotensin_offOrthosteric Ligandnts1_off
7.14Consensusnts1_offOrthosteric Ligand7UL2-NTS1-SR48692-Na
6.90Single6NBHLong-Acting PTH Analog6NBH-PTH1-Long-Acting PTH Analog-Gs/β1/γ2
6.90Single6WZGSecretin6WZG-Secretin-Secretin-Gs/β1/γ2
6.90Single7D68GLP-27D68-GLP-2-GLP-2-Gs/β1/γ2
6.90Single7VVJPTHrP(1-36)7VVJ-PTH1-PTHrP(1-36)-Gs/β1/γ2
6.90Single7VVLPTH7VVL-PTH1-PTH-Gs/β1/γ2
6.90Single8FLTM-PTH(1-14)8FLT-PTH1-M-PTH(1-14)-Gs/β1/γ2
6.90Single8HAFPTHrP(1-36)8HAF-PTH1-PTHrP(1-36)-chim(NtGi1-Gs)/β1/γ2
6.90Single8IY5Endothelin-18IY5-ETB-Endothelin-1-Gi1/β1/γ2
6.67Single3ODUIT1t3ODU-CXCR4-IT1t
6.67Single4K5YCP-3763954K5Y-CRF1-CP-376395
6.67Single5U09Taranabant5U09-CB1-Taranabant
6.67Single6RNKNF-56-EJ406RNK-Succinate-NF-56-EJ40
6.67Single7F8YDevazepide7F8Y-CCKA-Devazepide
6.67Single7LCJDanuglipron7LCJ-GLP-1-Danuglipron
6.67Single7S8PMS471347S8P-MRGPRX4-MS47134-chim(NtGi2L-Gs-CtGq)/β1/γ2
6.67Single7VIHCBP-3077VIH-S1P1-CBP-307-Gi1/β1/γ2
6.67Single7VV5C48/807VV5-MRGPRX2-C48/80-Gi1/β1/γ2
6.67Single7VVOPTH7VVO-PTH1-PTH-Gs/β1/γ2
6.67Single7WF7S1P7WF7-S1P1-S1P-Gi1/β1/γ2
6.67Single7X2CFenoldopam7X2C-D1-Fenoldopam-Fenoldopam-Gs/β1/γ2
6.67Single8DWHPubChem 1390305318DWH-MRGPRX1-PubChem 139030531-chim(NtGi2L-Gs-CtGq)/β1/γ2
6.67Single8H8JLodoxamide8H8J-GPR35-Lodoxamide-Ca-chim(NtGi1L-G13)/β1/γ2
6.67Single8HMPC178HMP-GPR52-C17-Gs/β1/γ2
6.67Single8T3VDocosa-4,7,10,13,16,19-Hexaenoic acid8T3V-FFA1-Docosa-4,7,10,13,16,19-Hexaenoic acid-chim(NtGi2L-Gs-CtGq)/β1/γ2
6.67Single8U4PAMD31008U4P-CXCR4-AMD3100-Cholesterol-Gi1/β1/γ2
6.67Single8XXXCXCL68XXX-CXCR2-CXCL6-Go/β1/γ2
6.67Single8ZJETAK-4488ZJE-Kiss1-TAK-448-chim(NtGi1-Gq)/β1/γ1
6.67Single9BA0A1AKN9BA0-CB1-A1AKN
6.67Consensusp2y1_onOrthosteric Ligand7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/β1/γ2
6.45Single6LPBPACAP6LPB-PAC1-PACAP-Gs/β1/γ1
6.45Single7SK6CXCL12_LRHQ7SK6-ACKR3-CXCL12_LRHQ
6.25Single3V2YPubChem 518926453V2Y-S1P1-PubChem 51892645
6.25Single6U1NLY21196206U1N-M2-LY2119620-Arrestin2
6.25Single7C2EPubChem 1490507997C2E-GLP-1-PubChem 149050799-Gs/β1/γ2
6.25Single7UTZPubChem 6440787UTZ-TSH-TR1402-PubChem 644078-Gs/β1/γ2
6.25Single7VV6C48/807VV6-MRGPRX2-C48/80
6.25Single7XOVSR1461317XOV-CCKA-SR146131-Gs/β1/γ2
6.25Single7XXH2MeSADP7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/β1/γ2
6.25Single7YK6PubChem 1383196747YK6-RXFP4-PubChem 138319674-Gi2/β1/γ2
6.25Single8GUQOlorinab8GUQ-CB2-Olorinab-Gi1/β1/γ2
6.25Single8GURCP55,9408GUR-CB2-CP55,940-Gi1/β1/γ2
6.25Single8HJ5PubChem 1390305318HJ5-MRGPRX1-PubChem 139030531-chim(NtGi1-Gs-CtGq)/β1/γ2
6.25Single8K2WAMG4878K2W-CXCR3-AMG487
6.25Single8K4NVF08K4N-GPR34-VF0-Gi1/β1/γ2
6.25Single8K9KDamgo8K9K-μ-Damgo-Gi3/β1/γ1
6.25Single8X7ATreprostinil8X7A-I2-Treprostinil-Gs/β1/γ2
6.25Single8Y62C16:0 Ceramide8Y62-FPR2-ALX-C16:0 Ceramide-Gi1/β1/γ2
6.25Single9JR2PTH9JR2-PTH1-PTH-chim(NtGi1L-Gs-CtGq)/β1/γ2
6.25Consensuscxcr3_offOrthosteric Ligand8K2W-CXCR3-AMG487
6.25Consensusp2y1_on_gpOrthosteric Ligand7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/β1/γ2
6.06Single8JITMEDI03828JIT-Glucagon-MEDI0382-Gs/β1/γ2
6.06Single9JR3PTH9JR3-PTH1-PTH-chim(NtGi1L-Gs-CtGq)/β1/γ2
5.88Single4QIMANTA XV4QIM-SMO-ANTA XV
5.88Single4Z9GCP-3763954Z9G-CRF1-CP-376395
5.88Single6X1ADanuglipron6X1A-GLP-1-Danuglipron-Gs/β1/γ2
5.88Single7LCIDanuglipron7LCI-GLP-1-Danuglipron-Gs/β1/γ2
5.88Single7LCKDanuglipron7LCK-GLP-1-Danuglipron
5.88Single7NA8PubChem 1780247NA8-Ghrelin-PubChem 178024-Gi1/β1/γ2
5.88Single7V3ZCP559407V3Z-CB1-CP55940
5.88Single8EFQDamgo8EFQ-μ-Damgo-Gi1/β1/γ2
5.88Single8EJKTAK-8758EJK-FFA1-TAK-875-chim(NtGi1L-Gs-CtGq)/β1/γ2
5.88Single8GTIBMK-C2058GTI-CRF1-BMK-C205
5.88Single8IC0Interleukin-88IC0-CXCR1-Interleukin-8-Gi1/β1/γ2
5.88Single8KEXDCA-3P8KEX-MRGPRX4-DCA-3P
5.88Single8T6JCDPPB8T6J-mGlu5; mGlu5-CDPPB
5.88Single8X9TAP5038X9T-ADGRD1-AP503-chim(NtGi1-Gs)/β1/γ2
5.88Single8XBGS3E-LysoPS8XBG-GPR34-S3E-LysoPS
5.88Single9B9ZA1AKO9B9Z-CB1-A1AKO
5.88Single9IYAONO-97105319IYA-GPR55-ONO-9710531
5.88Consensuscxcr1_on_gpOrthosteric Ligand8IC0-CXCR1-Interleukin-8-Gi1/β1/γ2
5.88Consensuslipid_offOrthosteric Ligandcannabinoid_off paf_off lpl_off prostanoid_off leukotriene_off
5.71Consensusmc2_onOrthosteric Ligand8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1
5.71Consensusmc2_on_gpOrthosteric Ligand8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1
5.56Single4JKVTaladegib4JKV-SMO-Taladegib
5.56Single6KPCPubChem 1459158896KPC-CB2-PubChem 145915889
5.56Single6LFMInterleukin-86LFM-CXCR2-Interleukin-8-Gi1/β1/γ2
5.56Single6Z4SSR486926Z4S-NTS1-SR48692
5.56Single7TD3S1P7TD3-S1P1-S1P-Gi1/β1/γ2
5.56Single7YU3ONO-07405567YU3-LPA1-ONO-0740556-Gi1/β1/γ2
5.56Single8GTGBMK-I1528GTG-CRF1-BMK-I152
5.56Single8IZ4Lysophosphatidylserine8IZ4-GPR34-Lysophosphatidylserine-Gi1/β1/γ2
5.56Single8JGGBAM8-228JGG-MRGPRX1-BAM8-22-Gi1/β1/γ2
5.56Single8K8JFenofibrate8K8J-CB1-Fenofibrate-chim(Gs-CtGq)/β1/γ2
5.56Single8T6JCDPPB8T6J-mGlu5; mGlu5-CDPPB
5.56Single9EAHNanobody AT2099EAH-AT1-Olmesartan-Nanobody AT209
5.56Consensuscb2_onOrthosteric Ligand8GUR-CB2-CP55,940-Gi1/β1/γ2 8GUS-CB2-HU-308-Gi1/β1/γ2 8GUT-CB2-LEI-102-Gi1/β1/γ2 6KPF-CB2-PubChem 145915889-Gi1/β1/γ2 6PT0-CB2-WIN 55212-2-Gi1/β1/γ2 8GUQ-CB2-Olorinab-Gi1/β1/γ2
5.56Consensuscb2_on_gpOrthosteric Ligand8GUR-CB2-CP55,940-Gi1/β1/γ2 8GUS-CB2-HU-308-Gi1/β1/γ2 8GUT-CB2-LEI-102-Gi1/β1/γ2 6KPF-CB2-PubChem 145915889-Gi1/β1/γ2 6PT0-CB2-WIN 55212-2-Gi1/β1/γ2 8GUQ-CB2-Olorinab-Gi1/β1/γ2
5.56Consensuscxcr2_on_gpOrthosteric Ligand6LFM-CXCR2-Interleukin-8-Gi1/β1/γ2
5.56Consensuslipid_onOrthosteric Ligandcannabinoid_on ffa_on lpl_on prostanoid_on leukotriene_on
5.56Consensuslipid_on_gpOrthosteric Ligandcannabinoid_on_gp ffa_on_gp lpl_on_gp prostanoid_on_gp leukotriene_on_gp
5.56Consensuslpa1_onOrthosteric Ligand7TD1-LPA1-LPA-Gi1/β1/γ2 7YU3-LPA1-ONO-0740556-Gi1/β1/γ2
5.56Consensuslpa1_on_gpOrthosteric Ligand7TD1-LPA1-LPA-Gi1/β1/γ2 7YU3-LPA1-ONO-0740556-Gi1/β1/γ2
5.26Single5V56TC1145V56-SMO-TC114
5.26Single5V57TC1145V57-SMO-TC114
5.26Single5XR8AM8415XR8-CB1-AM841
5.26Single5XRAAM115425XRA-CB1-AM11542
5.26Single6DDEDamgo6DDE-μ-Damgo-Gi1/β1/γ2
5.26Single6RZ5Zafirlukast6RZ5-CysLT1-Zafirlukast-Na
5.26Single6Z8NSRI-98296Z8N-NTS1-SRI-9829
5.26Single7EW3S1P7EW3-S1P3-S1P-Gi1/β1/γ2
5.26Single7F1TMIP-1a7F1T-CCR5-MIP-1a
5.26Single7FEECP559407FEE-CB1-CP55940-ZCZ011
5.26Single7R0CAVP7R0C-V2-AVP-Arrestin2
5.26Single7TD1LPA7TD1-LPA1-LPA-Gi1/β1/γ2
5.26Single7WV9CP559407WV9-CB1-CP55940-ZCZ011-Gi2/β1/γ2
5.26Single7XBDGalanin7XBD-GAL2-Galanin-chim(NtGi2L-Gs-CtGq)/β1/γ2
5.26Single7XJLSpexin7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/β1/γ2
5.26Single7XOWGastrin7XOW-CCKB-Gastrin-chim(NtGi1-Gq)/β1/γ2
5.26Single7XWONeurokinin-A7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
5.26Single7Y67C089 peptide7Y67-C5a1-C089 peptide-Gi1/β1/γ2
5.26Single7YU5ONO-07405567YU5-LPA1-ONO-0740556-Gi1/β1/γ2
5.26Single7YU7ONO-07405567YU7-LPA1-ONO-0740556-Gi1/β1/γ2
5.26Single8FMZNeurotensin/Neuromedin-N8FMZ-NTS1-Neurotensin/Neuromedin-N-chim(NtGi2L-Gs-CtGq)/β1/γ2
5.26Single8FN1Neurotensin/Neuromedin-N8FN1-NTS1-Neurotensin/Neuromedin-N-chim(NtGi1-Go)/β1/γ2
5.26Single8GUSHU-3088GUS-CB2-HU-308-Gi1/β1/γ2
5.26Single8HQCC5a anaphylatoxin8HQC-C5a1-C5a anaphylatoxin-Go/β1/γ2
5.26Single8JGFBAM8-228JGF-MRGPRX1-BAM8-22-chim(NtGi1-Gs-CtGq)/β1/γ2
5.26Single8WJXADP8WJX-P2Y1-ADP-chim(Gs-CtGq)/β1/γ2
5.26Single8XBIS3E-LysoPS8XBI-GPR34-S3E-LysoPS
5.26Single8XX7CXCL58XX7-CXCR2-CXCL5-Go/β1/γ2
5.26Single9GE2ML1849GE2-GPR55-ML184-Cholesterol-chim(CtGi1-G13)/β1/γ2
5.26Single9ITELPA9ITE-LPA6-LPA-chim(NtGi2-G13)/β1/γ2
5.26Consensuscyslt1_offOrthosteric Ligand6RZ5-CysLT1-Zafirlukast-Na 6RZ4-CysLT1-Pranlukast-Na
5.26Consensusgi_cannabinoidOrthosteric Ligand8GUR-CB2-CP55,940-Gi1/β1/γ2 8GUS-CB2-HU-308-Gi1/β1/γ2 8GUT-CB2-LEI-102-Gi1/β1/γ2 8GUQ-CB2-Olorinab-Gi1/β1/γ2 6KPF-CB2-PubChem 145915889-Gi1/β1/γ2 6PT0-CB2-WIN 55212-2-Gi1/β1/γ2 6KPG-CB1-AM841-Gi1/β1/γ2
5.26Consensusgi_lpaOrthosteric Ligand7TD1-LPA1-LPA-Gi1/β1/γ2 7YU3-LPA1-ONO-0740556-Gi1/β1/γ2
5.26Consensuslpa_onOrthosteric Ligandlpa1_on
5.26Consensuslpa_on_gpOrthosteric Ligandlpa1_on_gp
5.26Consensusnk2_on_gpOrthosteric Ligand7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
5.26Consensusp2y12_onOrthosteric Ligand7XXI-P2Y12-2MeSADP-Gi2/β1/γ2
5.00Single4PXZ2MeSADP4PXZ-P2Y12-2MeSADP
5.00Single4PY02MeSATP4PY0-P2Y12-2MeSATP
5.00Single4XEENeurotensin4XEE-NTS1-Neurotensin
5.00Single4XESNeurotensin4XES-NTS1-Neurotensin
5.00Single6KQICP559406KQI-CB1-CP55940-Org27569
5.00Single6OS0Angiotensinogen6OS0-AT1-Angiotensinogen
5.00Single6OS2TRV0266OS2-AT1-TRV026
5.00Single6RZ7ONO-25703666RZ7-CysLT2-ONO-2570366
5.00Single6XOXOrforglipron6XOX-GLP-1-Orforglipron-chim(NtGi1-Gs)/β1/γ2
5.00Single6YVRNTS8-136YVR-NTS1-NTS8-13
5.00Single7EW2Fingolimod7EW2-S1P3-Fingolimod-Gi1/β1/γ2
5.00Single7W0NElabela7W0N-Apelin-Elabela-Gi1/β1/γ2
5.00Single7XXI2MeSADP7XXI-P2Y12-2MeSADP-Gi2/β1/γ2
5.00Single8DWCProenkephalin-A8DWC-MRGPRX1-Proenkephalin-A-chim(NtGi2L-Gs-CtGq)/β1/γ2
5.00Single8GTMBMK-C2038GTM-CRF1-BMK-C203
5.00Single8JPBNeurotensin-(8-13)8JPB-NTS1-Neurotensin-(8-13)-PubChem 118610427; GDP; Mg-Gq; GRK2
5.00Single8JPCNeurotensin-(8-13)8JPC-NTS1-Neurotensin-(8-13)-PubChem 118610427; GDP; Mg-Gq; GRK2
5.00Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/β1/γ2
5.00Single8U26Protachykinin-18U26-NK1-Protachykinin-1-Gs/β1/γ2
5.00Single8WRBLysophosphatidylserine8WRB-GPR34-Lysophosphatidylserine-Gi1/β1/γ2
5.00Single8XWACXCL18XWA-CXCR2-CXCL1
5.00Single8XWMCXCL68XWM-CXCR2-CXCL6
5.00Single8XWSCXCL58XWS-CXCR2-CXCL5
5.00Single8XX3CXCL38XX3-CXCR2-CXCL3-Go/β1/γ2
5.00Single8ZPLHF511168ZPL-CXCR4-HF51116-Cholesterol
5.00Consensuscannabinoid_onOrthosteric Ligandcb2_on cb1_on
5.00Consensuscannabinoid_on_gpOrthosteric Ligandcb2_on_gp cb1_on_gp
5.00Consensuscb1_onOrthosteric Ligand6KPG-CB1-AM841-Gi1/β1/γ2 8K8J-CB1-Fenofibrate-chim(Gs-CtGq)/β1/γ2
5.00Consensusgalanin_onOrthosteric Ligandgal2_on gal1_on
5.00Consensusgalanin_on_gpOrthosteric Ligandgal2_on_gp gal1_on_gp
5.00Consensusgi_p2yOrthosteric Ligand7XXI-P2Y12-2MeSADP-Gi2/β1/γ2
5.00Consensuslipid_offonOrthosteric Ligandlipid_off lipid_on
5.00Consensuslipid_offon_gpOrthosteric Ligandlipid_on_gp lipid_off
5.00Consensusp2y12_on_gpOrthosteric Ligand7XXI-P2Y12-2MeSADP-Gi2/β1/γ2
4.88Single8GY7Corticotropin8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1
4.76Single4BUONeurotensin4BUO-NTS1-Neurotensin
4.76Single6RZ9ONO-27703726RZ9-CysLT2-ONO-2770372
4.76Single6UP7Neurotensin6UP7-NTS1-Neurotensin-Arrestin2
4.76Single7D7MDinoprostone7D7M-EP4-Dinoprostone-Gs/β1/γ1
4.76Single7P00Substance-P7P00-NK1-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
4.76Single8FN0Neurotensin/Neuromedin-N8FN0-NTS1-Neurotensin/Neuromedin-N-PubChem 118610427-chim(NtGi1-Go)/β1/γ2
4.76Single8GUTLEI-1028GUT-CB2-LEI-102-Gi1/β1/γ2
4.76Single8JPFNeurotensin8JPF-NTS1-Neurotensin-PubChem 118610427
4.76Single8K4OCXCL18K4O-KSHV-CXCL1-Gi1/β1/γ1
4.76Single8XBES3E-LysoPS8XBE-GPR34-S3E-LysoPS-Gi1/β1/γ1
4.76Single8XVUCXCL28XVU-CXCR2-CXCL2
4.76Single8XWFCXCL38XWF-CXCR2-CXCL3
4.76Single8XWVCXCL18XWV-CXCR2-CXCL1-Go/β1/γ2
4.76Single8XXHCXCL28XXH-CXCR2-CXCL2-Go/β1/γ2
4.76Single8ZX4Lysophosphatidylinositol 8ZX4-GPR55-Lysophosphatidylinositol-chim(NtGi1-G13)/β1/γ2
4.76Single9GE3Lysophosphatidylinositol9GE3-GPR55-Lysophosphatidylinositol-chim(CtGi1-G13)/β1/γ2
4.76Consensuscb1_on_gpOrthosteric Ligand6KPG-CB1-AM841-Gi1/β1/γ2 8K8J-CB1-Fenofibrate-chim(Gs-CtGq)/β1/γ2
4.76Consensuscyslt2_offOrthosteric Ligand6RZ7-CysLT2-ONO-2570366 6RZ8-CysLT2-ONO-2080365 6RZ9-CysLT2-ONO-2770372
4.76Consensusgal2_onOrthosteric Ligand7WQ4-GAL2-Galanin-chim(NtGi1-Gs-CtGq)/β1/γ2 7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/β1/γ2
4.76Consensusgal2_on_gpOrthosteric Ligand7WQ4-GAL2-Galanin-chim(NtGi1-Gs-CtGq)/β1/γ2 7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/β1/γ2
4.76Consensusnk1_onOrthosteric Ligand7P00-NK1-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
4.76Consensusnk1_on_gpOrthosteric Ligand7P00-NK1-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
4.76Consensusnk2_onOrthosteric Ligand7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
4.55Single6KNMJN241-96KNM-Apelin-JN241-9
4.55Single6OS9JMV4496OS9-NTS1-JMV449-Gi1/β1/γ2
4.55Single6RZ6ONO-25703666RZ6-CysLT2-ONO-2570366
4.55Single7F9ZGHRP-67F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/β1/γ2
4.55Single7RMGSubstance-P7RMG-NK1-Substance-P-chim(Gs-CtGq)/β1/γ2
4.55Single7RMHSubstance-P7RMH-NK1-Substance-P-Gs/β1/γ2
4.55Single7X8SWB4-247X8S-GLP-1-WB4-24-Gs/β1/γ2
4.55Single7Y1FDynorphin7Y1F-κ-Dynorphin-Gi1/β1/γ2
4.55Single8F7REndomorphin8F7R-μ-Endomorphin-Gi1/β1/γ2
4.55Single8SAI1-Oleoyl-2-Hydroxy-Sn-Glycero-3-Phospho-L-Serine8SAI-GPR34-1-Oleoyl-2-Hydroxy-Sn-Glycero-3-Phospho-L-Serine-Gi1/β1/γ2
4.55Single8XQJJN2418XQJ-Apelin-JN241
4.55Single8XX6CXCL88XX6-CXCR2-CXCL8-Go/β1/γ2
4.55Single9EAJNanobody AT2099EAJ-AT1-Nanobody AT209
4.55Consensuskiss1_onOrthosteric Ligand8ZJD-Kiss1-Kisspeptin-10-chim(NtGi1-Gq)/β1/γ1
4.55Consensuskisspeptin_onOrthosteric Ligandkiss1_on
4.35Single6RZ8ONO-20803656RZ8-CysLT2-ONO-2080365
4.35Single7NA7Ghrelin-277NA7-Ghrelin-Ghrelin-27-Gi1/β1/γ2
4.35Single7RTBPeptide-197RTB-GLP-1-Peptide-19-Gs/β1/γ2
4.35Single8DWGProenkephalin-A8DWG-MRGPRX1-Proenkephalin-A-ML382-chim(NtGi2L-Gs-CtGq)/β1/γ2
4.35Single8F7XNociceptin8F7X-NOP-Nociceptin-Gi1/β1/γ2
4.35Single8GHVAMG3158GHV-CB1-AMG315-Gi1/β1/γ2
4.35Single8IZBLysophosphatidylserine8IZB-GPR174-Lysophosphatidylserine-Gs/β1/γ2
4.35Single8XBHS3E-LysoPS8XBH-GPR34-S3E-LysoPS-Gi1/β1/γ2
4.35Single8XWNCXCL88XWN-CXCR2-CXCL8
4.35Single8ZJDKisspeptin-108ZJD-Kiss1-Kisspeptin-10-chim(NtGi1-Gq)/β1/γ1
4.35Consensuschemokine_onOrthosteric Ligandccr_on cxcr_on
4.35Consensusgq_kisspeptinOrthosteric Ligand8ZJD-Kiss1-Kisspeptin-10-chim(NtGi1-Gq)/β1/γ1
4.35Consensuskiss1_on_gpOrthosteric Ligand8ZJD-Kiss1-Kisspeptin-10-chim(NtGi1-Gq)/β1/γ1
4.35Consensuskisspeptin_on_gpOrthosteric Ligandkiss1_on_gp
4.35Consensuslpl_onOrthosteric Ligands1p_on lpa_on
4.35Consensuslpl_on_gpOrthosteric Ligands1p_on_gp lpa_on_gp
4.35Consensusnop_onOrthosteric Ligand8F7X-NOP-Nociceptin-Gi1/β1/γ2
4.35Consensusnop_on_gpOrthosteric Ligand8F7X-NOP-Nociceptin-Gi1/β1/γ2
4.35Consensusp2y_onOrthosteric Ligandp2y1_on p2y10_on p2y12_on
4.17Single7SHEPI; PE7SHE-GPR158-PI; PE
4.17Single7SHFPI; PE7SHF-GPR158-PI; PE-B5; RGS7
4.17Single7VBINon-Acylated Tirzepatide7VBI-GLP-1-Non-Acylated Tirzepatide-Gs/β1/γ2
4.17Single8F7QBeta-Endorphin8F7Q-μ-β-Endorphin-Gi1/β1/γ2
4.17Single8IBVMotilin8IBV-Motilin-Motilin-chim(NtGi1-Gs-CtGq)/β1/γ2
4.17Single8JBHSubstance-P8JBH-NK3-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
4.17Single8K6OPro-neuropeptide-Y8K6O-Y1-Pro-neuropeptide-Y-Gi2/β1/γ1
4.17Single8KH5Lysophosphatidylserine8KH5-GPR174-Lysophosphatidylserine-Gs/β1/γ2
4.17Consensustachykinin_on_gpOrthosteric Ligandnk1_on_gp nk2_on_gp nk3_on_gp
4.00Single9IVMGLP-1 (Truncated)9IVM-GLP-1-GLP-1 (Truncated)-LSN3318839-chim(NtGi1-Gs)/β2/γ2
3.85Single6NIYAdrenomedullin6NIY-CT-Adrenomedullin-Gs/β1/γ2
3.85Single7FINPeptide-20; GGL7FIN-GIP-Peptide-20; GGL-Gs/β1/γ2
3.85Single8YW3Retatrutide8YW3-GLP-1-Retatrutide-Gs/β1/γ2
3.85Single8YW4Retatrutide8YW4-GIP-Retatrutide-chim(NtGi1-Gs)/β1/γ22
3.85Consensusneuromedin-u_onOrthosteric Ligandnmur1_on nmur2_on
3.85Consensusp2y_on_gpOrthosteric Ligandp2y1_on_gp p2y10_on_gp p2y12_on_gp
3.85Consensustachykinin_onOrthosteric Ligandnk1_on nk2_on nk3_on
3.70Single5YQZGlucagon analogue5YQZ-Glucagon-Glucagon analogue
3.70Single6X18GLP-16X18-GLP-1-GLP-1-Gs/β1/γ2
3.70Single7F9YGhrelin-287F9Y-Ghrelin-Ghrelin-28-chim(NtGi1-Gs-CtGq)/β1/γ2
3.70Single7LLYOxyntomodulin7LLY-GLP-1-Oxyntomodulin-Gs/β1/γ2
3.57Single7D3SSecretin7D3S-Secretin-Secretin-Gs/β1/γ2
3.57Single7RA3GIP7RA3-GIP-GIP-chim(NtGi1-Gs)/β1/γ2
3.57Single7SK3CXCL127SK3-ACKR3-CXCL12
3.57Single7SK4CXCL12_LRHQ7SK4-ACKR3-CXCL12_LRHQ
3.57Single8FLRPTHrP(1-36)8FLR-PTH1-PTHrP(1-36)-Gs/β1/γ2
3.57Single8JISPeptide-158JIS-GLP-1-Peptide-15-chim(NtGi1-Gs)/β1/γ2
3.45Single5NX2GLP-1 (Truncated)5NX2-GLP-1-GLP-1 (Truncated)
3.45Single7DTYGIP7DTY-GIP-GIP-Gs/β1/γ2
3.45Single7FIYTirzepatide7FIY-GIP-Tirzepatide-Gs/β1/γ2
3.45Single7VQXPACAP277VQX-VPAC1-PACAP27-Gs/β1/γ2
3.45Single8FU6Glucagon derivative ZP37808FU6-Glucagon-Glucagon derivative ZP3780-Gs/β1/γ2
3.45Consensusp2y10_on_gpOrthosteric Ligand8KGG-P2Y10-LPS-chim(NtGi2-G13)/β1/γ2
3.33Single8KGGLPS8KGG-P2Y10-LPS-chim(NtGi2-G13)/β1/γ2
3.23Single7RBTTirzepatide7RBT-GIP-Tirzepatide-PubChem 163183774-chim(NtGi1-Gs)/β1/γ2
3.23Single8U1UCCL18U1U-CCR8-CCL1-Gi1/β1/γ2
3.12Single7VBHPeptide-207VBH-GLP-1-Peptide-20-Gs/β1/γ2
3.03Single7V35Peptide-207V35-Glucagon-Peptide-20-Gs/β1/γ2
3.03Single8JIPMEDI03828JIP-GLP-1-MEDI0382-chim(NtGi1-Gs)/β1/γ2
3.03Single8JIRSAR4258998JIR-GLP-1-SAR425899-chim(NtGi1-Gs)/β1/γ2
2.94Single8JIUSAR4258998JIU-Glucagon-SAR425899-Gs/β1/γ2

Consensus Members
Id Members
8IU2 8IU2-Opsin1LW-Retinal-Gi1/β1/γ2
Net Summary
Imin 2.59
Number of Linked Nodes 820
Number of Links 1016
Number of Hubs 171
Number of Links mediated by Hubs 653
Number of Communities 28
Number of Nodes involved in Communities 257
Number of Links involved in Communities 376
Path Summary
Number Of Nodes in MetaPath 134
Number Of Links MetaPath 133
Number of Shortest Paths 5621524
Length Of Smallest Path 3
Average Path Length 50.9677
Length of Longest Path 84
Minimum Path Strength 1.375
Average Path Strength 5.91124
Maximum Path Strength 26.785
Minimum Path Correlation 0.7
Average Path Correlation 0.993375
Maximum Path Correlation 1
Minimum % Of Corr. Nodes 1.5625
Average % Of Corr. Nodes 28.281
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 43.7545
Maximum Path Hubs % 100

Details about the values in these tables can be found in the corresponding documentation page .

This network is also present in following consensuses:
IdComponents
gi_sensorygi_opsins



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Download gi_opsins.zip



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