Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg Int. Strength Num Of Links Community ConSurf
1B:B:L7 3.55408
2B:B:L14 3.775408
3B:B:T34 3.3525405
4B:B:V40 4.211676103
5B:B:L51 7.83489
6B:B:H54 6.72429789
7B:B:Y59 9.66518
8B:B:W63 6.94507
9B:B:V71 4.35478
10B:B:S74 4.8825489
11B:B:D76 6.35589
12B:B:L79 5.556577
13B:B:I80 7.4125488
14B:B:W82 8.90286789
15B:B:Y85 11.46494
16B:B:N88 4.065207
17B:B:K89 8.44333689
18B:B:I93 8.2025477
19B:B:L95 4.874578
20B:B:W99 8.30857719
21B:B:Y105 5.04406
22B:B:N110 7.2154174
23B:B:Y111 7.045174
24B:B:V112 4.0125478
25B:B:C114 4.2425478
26B:B:N119 4.1475419
27B:B:C121 3.7375418
28B:B:Y124 5.16776
29B:B:E130 4.9403
30B:B:V133 6.855474
31B:B:H142 8.308519
32B:B:Y145 5.79625818
33B:B:C149 3.84418
34B:B:F151 4.675609
35B:B:L152 3.45403
36B:B:I157 4.106517
37B:B:T159 4.69833619
38B:B:D163 9.375419
39B:B:W169 7.76429718
40B:B:F180 8.618567
41B:B:H183 8.125669
42B:B:D186 3.982519
43B:B:V187 4.2525469
44B:B:L190 5.495465
45B:B:F199 8.136569
46B:B:V200 8.4975456
47B:B:S201 5.5725469
48B:B:A203 4.6875468
49B:B:C204 5.945417
50B:B:D205 7.192569
51B:B:K209 9.616566
52B:B:L210 4.8825405
53B:B:W211 9.26667668
54B:B:Q220 8.0275457
55B:B:F222 8.61458
56B:B:H225 12.088559
57B:B:D228 8.85419
58B:B:I232 4.7075458
59B:B:F235 7.941437116
60B:B:P236 6.36254117
61B:B:N237 6.79754115
62B:B:F241 7.84333656
63B:B:T243 7.38458
64B:B:T249 5.8456
65B:B:R251 12.442558
66B:B:F253 7.68333656
67B:B:R256 6.615409
68B:B:D258 11.69457
69B:B:Q259 3.385406
70B:B:Y264 7.46333605
71B:B:F278 5.3456117
72B:B:R283 5.855109
73B:B:L284 4.774105
74B:B:L285 4.7475406
75B:B:Y289 8.876507
76B:B:N295 8.96254226
77B:B:K301 5.315405
78B:B:V307 3.934223
79B:B:H311 10.28254129
80B:B:V327 3.7975406
81B:B:T329 6.13408
82B:B:W332 15.7833619
83B:B:D333 9.8654129
84B:B:L336 3.932587
85B:B:K337 9.084126
86B:B:W339 10.6325129
87A:A:V34 5.41754235
88A:A:L37 4.9625409
89A:A:Q52 4.4425409
90A:A:I184 7.065419
91A:A:F191 8.76254155
92A:A:F196 7.9554237
93A:A:K197 7.95416
94A:A:F199 7.884515
95A:A:Q204 7.2225419
96A:A:S206 5.735418
97A:A:R208 4.3375419
98A:A:K210 7.08619
99A:A:W211 6.37857719
100A:A:H213 6.1775418
101A:A:F215 7.832519
102A:A:I222 3.885407
103A:A:V225 5.415407
104A:A:D229 6.5075448
105A:A:Y230 7.855648
106A:A:L232 7.7325448
107A:A:L234 6.2825408
108A:A:R242 10.1475449
109A:A:F250 6.576519
110A:A:N255 6.715408
111A:A:W258 7.09505
112A:A:F259 6.95254249
113A:A:L268 5.385408
114A:A:N269 5.7054149
115A:A:F274 5.045449
116A:A:K277 8.2725449
117A:A:I278 4.735446
118A:A:C286 4.274546
119A:A:Y287 6.76714747
120A:A:Y290 8.905407
121A:A:Y296 6.644504
122A:A:Y320 7.1456167
123A:A:T321 8.27415
124A:A:T324 5.71254149
125A:A:N331 6.834148
126A:A:F336 5.165158
127A:A:D341 10.84754168
128A:A:L353 4.49833637
129A:A:F354 5.0075435
130G:G:L19 3.4975409
131G:G:R27 5.4075408
132G:G:Y40 7.4954116
133G:G:D48 5.303336109
134G:G:L51 3.03406
135G:G:N59 6.582599
136G:G:P60 6.765499
137G:G:F61 5.08125898
138R:R:Y34 5.10167626
139R:R:I57 3.125404
140R:R:I63 4.1508
141R:R:N67 5.192509
142R:R:V70 3.56254139
143R:R:F80 9.423336138
144R:R:L91 5.128539
145R:R:D95 6.084509
146R:R:Y102 10.956507
147R:R:T109 3.6325425
148R:R:T113 4.36425
149R:R:L116 3.406526
150R:R:W121 8.43529
151R:R:R124 6.90286726
152R:R:Q125 10.015424
153R:R:D129 6.7675425
154R:R:L132 4.97427
155R:R:V136 5.5725428
156R:R:L139 5.0325438
157R:R:L140 4.7125407
158R:R:R146 6.166539
159R:R:H147 8.62754257
160R:R:F151 11.99754256
161R:R:R152 7.702535
162R:R:V164 3.7325407
163R:R:W172 4.5675409
164R:R:M178 4.145425
165R:R:I189 3.99403
166R:R:I192 3.8475401
167R:R:M198 7.8325183
168R:R:Y202 8.05167624
169R:R:Y206 8.9527
170R:R:W210 5.14526
171R:R:N214 9.2925427
172R:R:M221 2.525409
173R:R:Y225 5.72439
174R:R:Y231 8.8025406
175R:R:R235 5.98754157
176R:R:T236 4.145405
177R:R:M253 3.985407
178R:R:F267 10.08429
179R:R:W271 7.37375828
180R:R:P273 4.37409
181R:R:D281 7.6654184
182R:R:V282 4.165405
183R:R:V289 3.0185184
184R:R:Y311 5.19571739
185R:R:R314 8.752537
186R:R:M318 6.71754138
187L:L:?1 7.952141420
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
1B:B:W297 B:B:Y264 18.482615.43NoYes085
2B:B:W297 B:B:Y289 18.64545.79NoYes087
3B:B:I269 B:B:Y289 19.71736.04NoYes047
4B:B:D291 B:B:I269 20.15324.2NoNo084
5B:B:C271 B:B:D291 22.16046.22NoNo058
6B:B:C271 B:B:D290 22.59653.11NoNo056
7B:B:D290 B:B:R314 23.261622.63NoNo068
8B:B:R314 B:B:W332 23.479530.99NoYes089
9B:B:W332 B:B:Y59 53.35869.65YesYes198
10B:B:Q75 B:B:Y59 55.778814.65NoYes198
11B:B:Q75 B:B:W99 57.98414.38NoYes199
12B:B:L117 B:B:W99 34.06484.56NoYes199
13A:A:W211 B:B:L117 34.27593.42YesNo199
14A:A:W211 B:B:Y145 34.45566.75YesYes198
15B:B:G162 B:B:Y145 32.44978.69NoYes198
16B:B:G162 B:B:S161 32.39613.71NoNo199
17B:B:H142 B:B:S161 31.683415.34YesNo199
18B:B:H142 B:B:T159 26.07825.48YesYes199
19B:B:C149 B:B:T159 21.30493.38YesYes189
20B:B:C149 B:B:T102 21.40975.07YesNo088
21B:B:C148 B:B:T102 21.29283.38NoNo068
22B:B:C148 B:B:L190 21.17596.35NoYes065
23B:B:L190 B:B:S160 16.33597.51YesNo056
24B:B:S160 B:B:V187 16.0994.85NoYes069
25B:B:A203 B:B:V187 15.13353.39YesYes689
26B:B:A203 B:B:G202 14.53411.95YesNo086
27B:B:G202 B:B:I229 14.41413.53NoNo067
28A:A:F215 B:B:W99 34.089915.03YesYes199
29A:A:F215 A:A:W211 35.70434.01YesYes199
30B:B:S316 B:B:W332 29.43937.41NoYes099
31B:B:C317 B:B:S316 29.22113.44NoNo079
32B:B:C317 B:B:M61 29.0044.86NoNo076
33B:B:M61 B:B:W63 28.57313.49NoYes067
34B:B:T321 B:B:W63 16.050912.13NoYes077
35B:B:D323 B:B:T321 15.15817.23NoNo1977
36B:B:D323 B:B:M325 14.96085.54NoNo075
37B:B:M325 G:G:P49 15.15145.03NoNo057
38G:G:D48 G:G:P49 14.71124.83YesNo097
39A:A:D341 R:R:T236 96.21697.23YesYes085
40A:A:D341 R:R:M239 95.94546.93YesNo1687
41A:A:F334 R:R:M239 96.47643.73NoNo037
42A:A:F334 A:A:H322 96.563821.5NoNo039
43A:A:H322 A:A:N331 96.73876.38NoYes098
44A:A:N331 A:A:T324 96.70597.31YesYes1489
45A:A:N269 A:A:T324 98.87027.31YesYes1499
46A:A:C224 A:A:N269 99.57077.87NoYes079
47A:A:C224 A:A:S44 99.65673.44NoNo079
48A:A:A41 A:A:S44 99.82853.42NoNo079
49A:A:A41 A:A:E43 1003.02NoNo079
50A:A:D229 A:A:E43 49.96887.8YesNo489
51A:A:D229 A:A:L232 49.95524.07YesYes488
52A:A:D231 A:A:L232 50.15545.43NoYes498
53A:A:D231 A:A:Y230 50.13318.39NoYes498
54A:A:F274 A:A:Y230 97.99996.19YesYes498
55A:A:F274 A:A:L227 97.30556.09YesNo097
56A:A:L227 A:A:L268 97.71168.3NoYes078
57A:A:L268 A:A:T321 97.67832.95YesYes085
58A:A:L266 A:A:T321 97.45410.32NoYes195
59A:A:F223 A:A:L266 95.663.65NoNo199
60A:A:F223 A:A:L249 96.02196.09NoNo199
61A:A:L249 A:A:R208 95.84423.64NoYes199
62A:A:R208 A:A:W211 95.71856YesYes199
63A:A:E43 A:A:R242 50.116911.63NoYes499
64A:A:L232 A:A:R242 50.449915.79YesYes489
65A:A:K277 A:A:L232 50.25495.64YesYes498
66A:A:K277 A:A:Y230 50.24275.97YesYes498
67A:A:L348 A:A:L353 44.75614.15NoYes097
68A:A:L348 R:R:V232 44.97355.96NoNo097
69R:R:T236 R:R:V232 90.81513.17YesNo057
70A:A:L353 R:R:L256 44.75365.54YesNo077
71R:R:L256 R:R:V232 45.75914.47NoNo077
72A:A:L353 R:R:R146 85.12336.07YesYes379
73R:R:R146 R:R:Y311 61.78856.17YesYes399
74R:R:L139 R:R:Y311 37.98123.52YesYes389
75R:R:L139 R:R:N307 34.258.24YesNo089
76R:R:N303 R:R:N307 34.23336.81NoNo099
77R:R:N303 R:R:W271 33.56437.91NoYes098
78R:R:W210 R:R:W271 28.72644.69YesYes268
79L:L:?1 R:R:W210 25.56758.04YesYes206
80R:R:I142 R:R:R146 23.39033.76NoYes389
81R:R:I142 R:R:L91 23.17644.28NoYes389
82R:R:D95 R:R:L91 39.71935.43YesYes099
83R:R:D95 R:R:N67 26.78728.08YesYes099
84R:R:I63 R:R:V59 12.76163.07YesNo087
85R:R:L298 R:R:V59 11.86212.98NoNo067
86R:R:L298 R:R:Y102 10.06697.03NoYes067
87R:R:L91 R:R:Y311 23.1823.52YesYes399
88R:R:D95 R:R:S304 12.17645.89YesNo099
89R:R:A92 R:R:N67 13.80214.69NoYes099
90R:R:A92 R:R:V70 12.88353.39NoYes099
91R:R:M318 R:R:V70 11.0454.56YesYes1389
92R:R:F80 R:R:M318 10.126411.2YesYes1388
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


2D representation of the interactions of this orthosteric/allosteric ligand.


Links and nodes colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:K39 R:R:Y34 10.75 2 No Yes 8 6 1 1
R:R:T113 R:R:Y34 7.49 2 Yes Yes 5 6 1 1
R:R:P200 R:R:Y34 5.56 0 No Yes 6 6 2 1
L:L:?1 R:R:Y34 3.31 2 Yes Yes 0 6 0 1
L:L:?1 R:R:K39 8.96 2 Yes No 0 8 0 1
R:R:K294 R:R:V52 13.66 2 No No 4 5 1 2
R:R:M106 R:R:Y102 7.18 0 No Yes 6 7 2 2
R:R:L297 R:R:Y102 9.38 0 No Yes 6 7 1 2
R:R:L105 R:R:R124 6.07 0 No Yes 6 6 2 1
R:R:M106 R:R:T109 3.01 0 No Yes 6 5 2 1
R:R:N108 R:R:R124 8.44 0 No Yes 5 6 2 1
R:R:K294 R:R:T109 4.5 2 No Yes 4 5 1 1
L:L:?1 R:R:T109 5.2 2 Yes Yes 0 5 0 1
R:R:L116 R:R:T113 2.95 2 Yes Yes 6 5 2 1
R:R:R124 R:R:T113 3.88 2 Yes Yes 6 5 1 1
L:L:?1 R:R:T113 3.12 2 Yes Yes 0 5 0 1
R:R:L116 R:R:W121 3.42 2 Yes Yes 6 9 2 2
R:R:L116 R:R:R124 4.86 2 Yes Yes 6 6 2 1
R:R:R124 R:R:W121 8 2 Yes Yes 6 9 1 2
R:R:Q125 R:R:W121 16.43 2 Yes Yes 4 9 1 2
R:R:P200 R:R:W121 4.05 0 No Yes 6 9 2 2
R:R:Q125 R:R:R124 9.35 2 Yes Yes 4 6 1 1
L:L:?1 R:R:R124 7.72 2 Yes Yes 0 6 0 1
R:R:Q125 R:R:Y202 6.76 2 Yes Yes 4 4 1 1
L:L:?1 R:R:Q125 7.52 2 Yes Yes 0 4 0 1
R:R:D129 R:R:G126 5.03 2 Yes No 5 6 1 2
R:R:D129 R:R:Y202 9.2 2 Yes Yes 5 4 1 1
R:R:D129 R:R:Y206 8.05 2 Yes Yes 5 7 1 2
L:L:?1 R:R:D129 4.79 2 Yes Yes 0 5 0 1
R:R:L132 R:R:W210 3.42 2 Yes Yes 7 6 2 1
R:R:L132 R:R:W271 6.83 2 Yes Yes 7 8 2 2
R:R:M178 R:R:T133 4.52 2 Yes No 5 6 2 2
R:R:T133 R:R:W210 6.06 2 No Yes 6 6 2 1
R:R:M178 R:R:Y206 3.59 2 Yes Yes 5 7 2 2
R:R:M178 R:R:W210 3.49 2 Yes Yes 5 6 2 1
R:R:P182 R:R:Y202 11.13 2 No Yes 6 4 2 1
R:R:P182 R:R:Y206 18.08 2 No Yes 6 7 2 2
R:R:E293 R:R:M198 14.89 0 No Yes 4 3 1 2
R:R:A199 R:R:Y202 5.34 0 No Yes 4 4 2 1
R:R:Y202 R:R:Y206 10.92 2 Yes Yes 4 7 1 2
L:L:?1 R:R:Y202 4.96 2 Yes Yes 0 4 0 1
R:R:L207 R:R:L278 4.15 2 No No 6 6 1 1
R:R:L207 R:R:V282 2.98 2 No Yes 6 5 1 2
L:L:?1 R:R:L207 3.91 2 Yes No 0 6 0 1
R:R:W210 R:R:W271 4.69 2 Yes Yes 6 8 1 2
L:L:?1 R:R:W210 8.04 2 Yes Yes 0 6 0 1
L:L:?1 R:R:L278 6.84 2 Yes No 0 6 0 1
L:L:?1 R:R:E293 23.38 2 Yes No 0 4 0 1
L:L:?1 R:R:K294 6.97 2 Yes No 0 4 0 1
L:L:?1 R:R:L297 16.61 2 Yes No 0 6 0 1
R:R:L41 R:R:Y34 2.34 0 No Yes 2 6 2 1
R:R:G110 R:R:T109 1.82 0 No Yes 5 5 2 1
R:R:A211 R:R:L278 1.58 0 No No 4 6 2 1
R:R:N35 R:R:Y34 1.16 0 No Yes 7 6 2 1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

ShowSimilarityNetwork TypeNameLigandDescription
92.31Single7YU3ONO-07405567YU3-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
92.31Single7YU7ONO-07405567YU7-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
86.67Single7YU8ONO-07405567YU8-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
85.71Single7TD1LPA7TD1-LPA1-LPA-Gi1/&β;1/&γ;2
85.71Consensuslpa1_onOrthosteric Ligand7TD0-LPA1-LPA-Gi1/&β;1/&γ;2 7YU3-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
85.71Consensuslpa_onOrthosteric Ligandlpa1_on
84.62Single7YU4ONO-07405567YU4-LPA1-ONO-0740556
78.57Single7YU6ONO-07405567YU6-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
75.00Single4Z35ONO-99105394Z35-LPA1-ONO-9910539
73.33Consensuslpa_offOrthosteric Ligandlpa1_off
68.75Consensuslpa1_offOrthosteric Ligand4Z36-LPA1-ONO-3080573 4Z34-LPA1-ONO-9780307 4Z35-LPA1-ONO-9910539 7YU4-LPA1-ONO-0740556
68.42Single7TD2LPA7TD2-LPA1-LPA-Gi1/&β;1/&γ;2
62.50Single4Z34ONO-97803074Z34-LPA1-ONO-9780307
61.11Consensuslpl_offOrthosteric Ligands1p_off lpa_off
61.11Consensuslpl_onOrthosteric Ligands1p_on lpa_on
60.00Single7TD0LPA7TD0-LPA1-LPA-Gi1/&β;1/&γ;2
55.00Single8F7SDeltorphin8F7S-δ-Deltorphin-Gi1/&β;1/&γ;2
50.00Single4Z36ONO-30805734Z36-LPA1-ONO-3080573
47.62Single8F7WDynorphin8F7W-κ-Dynorphin-Gi1/&β;1/&γ;2
47.62Consensusgi_lplOrthosteric Ligand7EW3-S1P3-S1P-Gi1/&β;1/&γ;2 7TD4-S1P1-Siponimod-Gi1/&β;1/&γ;2 7VIF-S1P1-(S)-FTY720-P-Gi1/&β;1/&γ;2 7EO4-S1P1-BAF312-Gi1/&β;1/&γ;2 7VIG-S1P1-CBP-307-Gi1/&β;1/&γ;2 7EVZ-S1P1-Cenerimod-Gi1/&β;1/&γ;2 7EW4-S1P3-CYM5541-Gi1/&β;1/&γ;2 7EW2-S1P3-Fingolimod-Gi1/&β;1/&γ;2 7TD0-LPA1-LPA-Gi1/&β;1/&γ;2 7YU3-LPA1-ONO-0740556-Gi1/&β;1/&γ;2 7EW0-S1P1-Ozanimod-Gi1/&β;1/&γ;2 7EW7-S1P1-PubChem 4077460-Gi1/&β;1/&γ;2
47.37Single8WRZ8D08WRZ-CB1-8D0-Arrestin1
46.67Single7WF7S1P7WF7-S1P1-S1P-Gi1/&β;1/&γ;2
45.00Single8F7REndomorphin8F7R-μ-Endomorphin-Gi1/&β;1/&γ;2
45.00Consensusdop_onOrthosteric Ligand8F7S-δ-Deltorphin-Gi1/&β;1/&γ;2
44.44Single8HQCC5a anaphylatoxin8HQC-C5a1-C5a anaphylatoxin-Go/&β;1/&γ;2
42.86Single7TD4Siponimod7TD4-S1P1-Siponimod-Gi1/&β;1/&γ;2
42.31Consensusgq_peptideOrthosteric Ligandgq_cck gq_angiotensin gq_bombesin gq_bradykinin
42.11Single7EW2Fingolimod7EW2-S1P3-Fingolimod-Gi1/&β;1/&γ;2
41.67Single7P02Protachykinin-17P02-NK1-Protachykinin-1-chim(NtGi1-Gs)/&β;1/&γ;2
41.67Single7Y64C5a anaphylatoxin7Y64-C5a1-C5a anaphylatoxin-Gi1/&β;1/&γ;2
41.18Single7YK7DC5910537YK7-RXFP4-DC591053-Gi2/&β;1/&γ;2
41.18Consensuslipid_offOrthosteric Ligandcannabinoid_off leuko_off lpl_off paf_off prostanoid_off
41.18Consensusnucleotide_offOrthosteric Ligandadenosine_off p2y_off
40.91Single8F7QBeta-endorphin8F7Q-μ-Beta-endorphin-Gi1/&β;1/&γ;2
40.00Single6DDFDamgo6DDF-μ-Damgo-Gi1/&β;1/&γ;2
40.00Single7EW0Ozanimod7EW0-S1P1-Ozanimod-Gi1/&β;1/&γ;2
40.00Single8GUTLEI-1028GUT-CB2-LEI-102-Gi1/&β;1/&γ;2
40.00Single8IYSTUG-8918IYS-FFA4-TUG-891-GDP-chim(NtGi1L-Gq)/&β;1/&γ;2
39.13Consensusopioid_onOrthosteric Ligandkop_on mop_on nop_on dop_on
38.89Single5NM2ZM2413855NM2-A2A-ZM241385-Na
38.89Single6DDEDamgo6DDE-μ-Damgo-Gi1/&β;1/&γ;2
38.89Single7SBFPZM217SBF-μ-PZM21-Gi1/&β;1/&γ;2
38.89Single7TD3S1P7TD3-S1P1-S1P-Gi1/&β;1/&γ;2
38.89Single8DZQmomSalB8DZQ-κ-momSalB-Go/&β;1/&γ;2
38.89Consensusgo_opioidOrthosteric Ligand8DZQ-κ-momSalB-Go/&β;1/&γ;2
38.10Single7XY6PubChem 117178317XY6-A2B-PubChem 11717831-chim(NtGi1-Gs)/&β;1/&γ;2
38.10Single7Y1FDynorphin7Y1F-κ-Dynorphin-Gi1/&β;1/&γ;2
38.10Single8H4IDoconexent8H4I-FFA4-Doconexent-chim(NtGi1-Gs)/&β;1/&γ;2
38.10Consensusgi_lipidOrthosteric Ligandgi_cannabinoid gi_prostanoid gi_ffa gi_lpl gi_leukotriene
38.10Consensusgo_compl-peptideOrthosteric Ligand8I95-C3aB-EP54-Go/&β;1/&γ;2 8IA2-C5a1-C5a anaphylatoxin-Go/&β;1/&γ;2 8I9L-C3aB-C3a anaphylatoxin-Go/&β;1/&γ;2 8J6D-C3aB-EP141-Go/&β;1/&γ;2
38.10Consensusox2_onOrthosteric Ligand7L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7SR8-OX2-TAK-925-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
37.93Single6LRYSarafotoxin-B6LRY-ETB-Sarafotoxin-B
37.50Single3PWHZM2413853PWH-A2A-ZM241385
37.50Single3VGAZM2413853VGA-A2A-ZM241385-Antibody
37.50Single7C61Ergotamine7C61-5-HT1B-Ergotamine
37.50Single7TUZ7alpha,25-dihydroxycholesterol7TUZ-GPR183-7alpha,25-dihydroxycholesterol-Gi1/&β;1/&γ;2
37.50Single7VDLCortistatin-147VDL-MRGPRX2-Cortistatin-14-Gi1/&β;1/&γ;2
37.50Single8H4KGW95088H4K-FFA4-GW9508-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
37.50Single8T3SButyric acid8T3S-FFA2-Butyric acid-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
37.50Consensusp2y_offOrthosteric Ligandp2y1_off p2y12_off
37.04Single8IY5Endothelin-18IY5-ETB-Endothelin-1-Gi1/&β;1/&γ;2
36.84Single3P0GBI1671073P0G-β2-BI167107
36.84Single3SN6BI1671073SN6-β2-BI167107-Gs/&β;1/&γ;2
36.84Single4RWDDIPP-NH24RWD-δ-DIPP-NH2-Na
36.84Single5XRAAM115425XRA-CB1-AM11542
36.84Single7F58THIQ7F58-MC4-THIQ-Gs/&β;1/&γ;2
36.84Single7FEEPubMed 1048957FEE-CB1-PubMed 104895-ZCZ011
36.84Single7JVPSKF839597JVP-D1-SKF83959-Gs/&β;1/&γ;2
36.84Single7VIGCBP-3077VIG-S1P1-CBP-307-Gi1/&β;1/&γ;2
36.84Single8DCSCyanopindolol8DCS-β1-Cyanopindolol-Gs/&β;1/&γ;2
36.84Single8E0GBU728E0G-μ-BU72
36.84Single8HPTC5a anaphylatoxin C-terminal peptide8HPT-C5a1-C5a anaphylatoxin C-terminal peptide-Go/&β;1/&γ;2
36.84Single8I9AEP548I9A-C3aB-EP54-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
36.84Single8ID39-Hydroxystearic acid8ID3-FFA4 (GPR120)-9-Hydroxystearic acid-Gi1/&β;1/&γ;2
36.84Single8ID6Oleic acid8ID6-FFA4 (GPR120)-Oleic acid-Gi1/&β;1/&γ;2
36.84Single8XBIS3E-LysoPS8XBI-GPR34-S3E-LysoPS
36.84Consensusffa4_onOrthosteric Ligand8H4K-FFA4-GW9508-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8ID9-FFA4 (GPR120)-Eicosapentaenoic acid-Gi1/&β;1/&γ;2 8ID4-FFA4 (GPR120)-Linoleic acid-Gi1/&β;1/&γ;2 8ID6-FFA4 (GPR120)-Oleic acid-Gi1/&β;1/&γ;2 8G59-FFA4 (GPR120)-TUG-891-Gi1/&β;1/&γ;2 8ID3-FFA4 (GPR120)-9-Hydroxystearic acid-Gi1/&β;1/&γ;2 8H4I-FFA4-Doconexent-chim(NtGi1-Gs)/&β;1/&γ;2
36.84Consensusgi_ffaOrthosteric Ligand8ID6-FFA4 (GPR120)-Oleic acid-Gi1/&β;1/&γ;2 8G59-FFA4 (GPR120)-TUG-891-Gi1/&β;1/&γ;2 8ID3-FFA4 (GPR120)-9-Hydroxystearic acid-Gi1/&β;1/&γ;2 8ID9-FFA4 (GPR120)-Eicosapentaenoic acid-Gi1/&β;1/&γ;2 8ID4-FFA4 (GPR120)-Linoleic acid-Gi1/&β;1/&γ;2 8J22-FFA2-TUG-1375-Gi1/&β;1/&γ;2 8J24-FFA2-Acetic acid-Gi1/&β;1/&γ;2 8J21-FFA3-Butyric acid-Gi1/&β;1/&γ;2
36.84Consensusgs_compl-peptideOrthosteric Ligand8I9A-C3aB-EP54-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
36.36Single7F4ISHU91197F4I-MC1-SHU9119-chim(NtGi1-Gs)/&β;1/&γ;2
36.36Single7W0PElabela7W0P-Apelin-Elabela-Gi1/&β;1/&γ;2
36.36Single8GHVPubChem 1459649038GHV-CB1-PubChem 145964903-Gi1/&β;1/&γ;2
36.36Single8XBHS3E-LysoPS8XBH-GPR34-S3E-LysoPS-Gi1/&β;1/&γ;2
36.36Consensusapelin_onOrthosteric Ligand7W0P-Apelin-Elabela-Gi1/&β;1/&γ;2 7W0M-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
36.36Consensusgi_ghrelinOrthosteric Ligand7NA7-Ghrelin-Ghrelin-27-Gi1/&β;1/&γ;2 7NA8-Ghrelin-PubChem 178024-Gi1/&β;1/&γ;2
36.36Consensusgi_opioidOrthosteric Ligand8EF6-μ-Morphine-Gi1/&β;1/&γ;2 8F7Q-μ-Beta-endorphin-Gi1/&β;1/&γ;2 7U2K-μ-C6-guano-Gi1/&β;1/&γ;2 8EFQ-μ-Damgo-Gi1/&β;1/&γ;2 8F7S-δ-Deltorphin-Gi1/&β;1/&γ;2 8F7W-κ-Dynorphin-Gi1/&β;1/&γ;2 8F7R-μ-Endomorphin-Gi1/&β;1/&γ;2 8EF5-μ-Fentanyl-Gi1/&β;1/&γ;2 7SCG-μ-FH210-Gi1/&β;1/&γ;2 7T2H-μ-Lofentanil-Gi1/&β;1/&γ;2 7T2G-μ-Mitragynine pseudoindoxyl-Gi1/&β;1/&γ;2 8DZP-κ-momSalB-Gi1/&β;1/&γ;2 8F7X-NOP-Nociceptin-Gi1/&β;1/&γ;2 8EFB-μ-Oliceridine-Gi1/&β;1/&γ;2 8FEG-κ-PRD_002517-Gi1/&β;1/&γ;2 7U2L-μ-PubChem 163201242-Gi1/&β;1/&γ;2 8EFO-μ-PZM21-Gi1/&β;1/&γ;2 8EFL-μ-SR17018-Gi1/&β;1/&γ;2
36.00Single7F6HBradykinin7F6H-BK2-Bradykinin-Gq/&β;1/&γ;2
36.00Consensusc5a1_onOrthosteric Ligand7Y65-C5a1-C5a peptide-Gi1/&β;1/&γ;2 8HK5-C5a1-Complement C5-Gi1/&β;1/&γ;2 7Y66-C5a1-BM213-Gi1/&β;1/&γ;2 7Y67-C5a1-C089 peptide-Gi1/&β;1/&γ;2 7Y64-C5a1-C5a anaphylatoxin-Gi1/&β;1/&γ;2
35.71Single5GLHEndothelin-15GLH-ETB-Endothelin-1
35.71Single6IGKEndothelin-36IGK-ETB-Endothelin-3
35.29Single3V2YPubChem 518926453V2Y-S1P1-PubChem 51892645
35.29Single5IU4ZM2413855IU4-A2A-ZM241385-Na
35.29Single5IUBQ274563445IUB-A2A-Q27456344-Na
35.29Single5K2CZM2413855K2C-A2A-ZM241385-Na
35.29Single5NM4ZM2413855NM4-A2A-ZM241385-Na
35.29Single6AQFZM2413856AQF-A2A-ZM241385
35.29Single6PT0WIN 55212-26PT0-CB2-WIN 55212-2-Gi1/&β;1/&γ;2
35.29Single7AROLUF58337ARO-A2A-LUF5833-Na
35.29Single7SR8TAK-9257SR8-OX2-TAK-925-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
35.29Single7YK6PubChem 1383196747YK6-RXFP4-PubChem 138319674-Gi2/&β;1/&γ;2
35.29Single8GUQOlorinab8GUQ-CB2-Olorinab-Gi1/&β;1/&γ;2
35.29Single8GURPubChem 1048958GUR-CB2-PubChem 104895-Gi1/&β;1/&γ;2
35.29Consensusffa2_onOrthosteric Ligand8J24-FFA2-Acetic acid-Gi1/&β;1/&γ;2 8T3S-FFA2-Butyric acid-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8J22-FFA2-TUG-1375-Gi1/&β;1/&γ;2
35.29Consensuss1p1_offOrthosteric Ligand3V2Y-S1P1-PubChem 51892645
35.29Consensuss1p_offOrthosteric Ligands1p1_off
35.00Single2YCXCyanopindolol2YCX-β1-Cyanopindolol
35.00Single4LDEBI1671074LDE-β2-BI167107
35.00Single5F8UCyanopindolol5F8U-β1-Cyanopindolol
35.00Single6KPGAM8416KPG-CB1-AM841-Gi1/&β;1/&γ;2
35.00Single6KQIPubMed 1048956KQI-CB1-PubMed 104895-ORG27569
35.00Single6OS0Angiotensinogen6OS0-AT1-Angiotensinogen
35.00Single7YITNalfurafine7YIT-κ-Nalfurafine
35.00Single8I95EP548I95-C3aB-EP54-Go/&β;1/&γ;2
35.00Single8I9LC3a anaphylatoxin8I9L-C3aB-C3a anaphylatoxin-Go/&β;1/&γ;2
35.00Single8IA8E7 peptide8IA8-C3aB-E7 peptide-Gi1/&β;1/&γ;2
35.00Single8IJDMK68928IJD-HCA2-MK6892-Gi1/&β;1/&γ;2
35.00Single8JJ8Formoterol8JJ8-β2-Formoterol
35.00Single8JJLOlodaterol8JJL-β2-Olodaterol
35.00Single8JPBNeurotensin 8-138JPB-NTS1-Neurotensin 8-13-PubChem 118610427; GDP; Mg-Gq; GRK2
35.00Single8WU1KCA8WU1-CB1-KCA-Arrestin1
35.00Consensuscb1_off_alloOrthosteric Ligand6KQI-CB1-PubMed 104895-ORG27569
35.00Consensusmop_onOrthosteric Ligand8F7Q-μ-Beta-endorphin-Gi1/&β;1/&γ;2 8EFQ-μ-Damgo-Gi1/&β;1/&γ;2 8F7R-μ-Endomorphin-Gi1/&β;1/&γ;2 8EF5-μ-Fentanyl-Gi1/&β;1/&γ;2 8EF6-μ-Morphine-Gi1/&β;1/&γ;2 8EFB-μ-Oliceridine-Gi1/&β;1/&γ;2 8EFO-μ-PZM21-Gi1/&β;1/&γ;2 8EFL-μ-SR17018-Gi1/&β;1/&γ;2
35.00Consensusopioid_offOrthosteric Ligandkop_off mop_off nop_off dop_off
34.78Single7DDZJNJ-310200287DDZ-Y2-JNJ-31020028
34.78Single7RMISubstance P7RMI-NK1-Substance P-chim(Gs-CtGq)/&β;1/&γ;2
34.78Consensusnpy2_offOrthosteric Ligand7DDZ-Y2-JNJ-31020028
34.62Consensusgi_compl-peptideOrthosteric Ligand8HK5-C5a1-Complement C5-Gi1/&β;1/&γ;2 8IA8-C3aB-E7 peptide-Gi1/&β;1/&γ;2 7Y66-C5a1-BM213-Gi1/&β;1/&γ;2 7Y67-C5a1-C089 peptide-Gi1/&β;1/&γ;2 8HK2-C3aB-C3a anaphylatoxin-Gi1/&β;1/&γ;2 7Y64-C5a1-C5a anaphylatoxin-Gi1/&β;1/&γ;2 7Y65-C5a1-C5a peptide-Gi1/&β;1/&γ;2
34.48Single8HBDIRL16208HBD-ETB-IRL1620-Gi1/&β;1/&γ;2
34.48Consensusmelanocortin_onOrthosteric Ligandmc2_on mc1_on mc3_on mc4_on mc5_on
33.33Single3OE0CVX153OE0-CXCR4-CVX15
33.33Single4EIYZM2413854EIY-A2A-ZM241385-Na
33.33Single4PXZ2MeSADP4PXZ-P2Y12-2MeSADP
33.33Single4QIMPubChem 249053754QIM-SMO-PubChem 24905375
33.33Single4RWSvMIP-II4RWS-CXCR4-vMIP-II
33.33Single5IU8Q274563475IU8-A2A-Q27456347-Na
33.33Single5OLGZM2413855OLG-A2A-ZM241385-Na
33.33Single5UENDU1725UEN-A1-DU172
33.33Single5UIGJ3.651.884G5UIG-A2A-J3.651.884G
33.33Single6LI0GTPL98046LI0-GPR52-GTPL9804
33.33Single6LPJZM2413856LPJ-A2A-ZM241385-Na
33.33Single6LPKZM2413856LPK-A2A-ZM241385-Na
33.33Single6LW5WKYMVm6LW5-FPR2-ALX-WKYMVm
33.33Single6XBM25(S)-Epoxycholesterol6XBM-SMO-25(S)-Epoxycholesterol-Gi1/&β;1/&γ;2
33.33Single6Z4VNTS8-136Z4V-NTS1-NTS8-13
33.33Single7BU7BI1671077BU7-β1-BI167107
33.33Single7CRHSKF839597CRH-D1-SKF83959-Gs/&β;1/&γ;2
33.33Single7EVZCenerimod7EVZ-S1P1-Cenerimod-Gi1/&β;1/&γ;2
33.33Single7F4FAfamelanotide7F4F-MC1-Afamelanotide-chim(NtGi1-Gs)/&β;1/&γ;2
33.33Single7F53Alpha-MSH7F53-MC4-Alpha-MSH-Gs/&β;1/&γ;2
33.33Single7MBXCholecystokinin-87MBX-CCKA-Cholecystokinin-8-Gs/&β;1/&γ;1
33.33Single7O7F(6P4)CCL57O7F-CCR5-(6P4)CCL5-Gi1/&β;1/&γ;1
33.33Single7P00Substance P7P00-NK1-Substance P-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
33.33Single7PYRPSB-21157PYR-A2A-PSB-2115
33.33Single7V3ZPubMed 1048957V3Z-CB1-PubMed 104895
33.33Single7X2DTavapadon7X2D-D1-Tavapadon-Gs/&β;1/&γ;2
33.33Single7XJISolabegron7XJI-β3-Solabegron-Gs/&β;1/&γ;2
33.33Single7XK2MK68927XK2-HCA2-MK6892-Gi1/&β;1/&γ;2
33.33Single8GAGYVF8GAG-CB1-YVF-Gi1/&β;1/&γ;2
33.33Single8IC0Interleukin-88IC0-CXCR1-Interleukin-8-Gi1/&β;1/&γ;2
33.33Single8ID4Linoleic acid8ID4-FFA4 (GPR120)-Linoleic acid-Gi1/&β;1/&γ;2
33.33Single8J21Butyric acid8J21-FFA3-Butyric acid-Gi1/&β;1/&γ;2
33.33Single8J24Acetic acid8J24-FFA2-Acetic acid-Gi1/&β;1/&γ;2
33.33Single8JPFNeurotensin8JPF-NTS1-Neurotensin-PubChem 118610427
33.33Single8X17Namodenoson8X17-A3A-Namodenoson-Gi1/&β;1/&γ;2
33.33Consensusa2_offOrthosteric Liganda2a_off
33.33Consensusa2a_offOrthosteric Ligand8C9W-A2A-Etrumadenant 3UZA-A2A-GTPL9236 8GNG-A2A-Istradefylline 5UIG-A2A-J3.651.884G 8CU6-A2A-LJ-4517 7PX4-A2A-PSB-2113 7PYR-A2A-PSB-2115 8DU3-A2A-PubChem 105526064 8JWY-A2A-PubChem 168451710 5K2D-A2A-ZM241385
33.33Consensusangiotensin_onOrthosteric Ligandat1_on
33.33Consensusat1_onOrthosteric Ligand7F6G-AT1-SAR1-AngII-Gq/&β;1/&γ;2
33.33Consensusendothelin_onOrthosteric Ligandetb_on eta_on
33.33Consensusffa3_onOrthosteric Ligand8J21-FFA3-Butyric acid-Gi1/&β;1/&γ;2
33.33Consensusffa_onOrthosteric Ligandffa4_on ffa1_on ffa2_on ffa3_on
33.33Consensusgi_class-aOrthosteric Ligandgi_amine gi_lipid gi_melatonin gi_peptide gi_protein gi_nucleotide gi_hcar
33.33Consensusgi_neurotensinOrthosteric Ligand7L0P-NTS1-Neurotensin-Gi1/&β;1/&γ;1 6OS9-NTS1-JMV449-Gi1/&β;1/&γ;2
33.33Consensusgs_class-aOrthosteric Ligandgs_amine gs_nucleotide gs_lipid gs_peptide gs_protein gs_steroid
33.33Consensusgs_orexinOrthosteric Ligand7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7SR8-OX2-TAK-925-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
33.33Consensusorexin_onOrthosteric Ligandox2_on
33.33Consensuss1p1_onOrthosteric Ligand7TD3-S1P1-S1P-Gi1/&β;1/&γ;2 7TD4-S1P1-Siponimod-Gi1/&β;1/&γ;2 7VIF-S1P1-(S)-FTY720-P-Gi1/&β;1/&γ;2 7EO4-S1P1-BAF312-Gi1/&β;1/&γ;2 7VIG-S1P1-CBP-307-Gi1/&β;1/&γ;2 7EVZ-S1P1-Cenerimod-Gi1/&β;1/&γ;2 7EW0-S1P1-Ozanimod-Gi1/&β;1/&γ;2 7EW7-S1P1-PubChem 4077460-Gi1/&β;1/&γ;2
32.14Single6IGLIRL16206IGL-ETB-IRL1620
32.14Single8FEGPRD_0025178FEG-κ-PRD_002517-Gi1/&β;1/&γ;2
32.14Single8IY6Endothelin-18IY6-ETB-Endothelin-1
32.14Consensusgq_bradykininOrthosteric Ligand7F6H-BK2-Bradykinin-Gq/&β;1/&γ;2 7F6I-BK2-Kallidin-Gq/&β;1/&γ;2
32.14Consensusgs_endothelinOrthosteric Ligand8HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8HCX-ETB-Endothelin-1-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
32.14Consensuspeptide_onOrthosteric Ligandopioid_on angiotensin_on bombesin_on cck_on endothelin_on ghrelin_on npy_on nts_on orexin_on vasopressin-ot_on tachykinin_on sst_on relaxin_on trh_on nmur_on motilin_on melanocortin_on galanin_on fpr-alx_on compl-peptide_on bradykinin_on apelin_on
32.00Single7F6GSAR1-AngII7F6G-AT1-SAR1-AngII-Gq/&β;1/&γ;2
32.00Single8IA2C5a anaphylatoxin8IA2-C5a1-C5a anaphylatoxin-Go/&β;1/&γ;2
32.00Single8IHFMK68928IHF-HCA2-MK6892-Gi1/&β;1/&γ;2
32.00Single8XZJWN3538XZJ-Apelin-WN353-Gi1/&β;1/&γ;2
32.00Consensuscompl-peptide_onOrthosteric Ligandc5a1_on c3a_on
32.00Consensusghrelin_onOrthosteric Ligand7W2Z-Ghrelin-Ghrelin-Go/&β;1/&γ;2 7F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7NA8-Ghrelin-PubChem 178024-Gi1/&β;1/&γ;2
32.00Consensusgq_angiotensinOrthosteric Ligand7F6G-AT1-SAR1-AngII-Gq/&β;1/&γ;2
31.82Single3NY9PubChem 9131033NY9-β2-PubChem 913103
31.82Single6C1QPMX536C1Q-C5a1-PMX53-NDT9513727
31.82Single7NA7Ghrelin-277NA7-Ghrelin-Ghrelin-27-Gi1/&β;1/&γ;2
31.82Single7RKFFractalkine7RKF-US28-Fractalkine-GDP-chim(NtGi1-G11)/&β;1/&γ;2
31.82Single7RKNFractalkine7RKN-US28-Fractalkine-Gi1/&β;1/&γ;2
31.82Single7RMGSubstance P7RMG-NK1-Substance P-chim(Gs-CtGq)/&β;1/&γ;2
31.82Single7W2ZGhrelin7W2Z-Ghrelin-Ghrelin-Go/&β;1/&γ;2
31.82Single7YJ4INSL57YJ4-RXFP4-INSL5-Gi2/&β;1/&γ;2
31.82Single8JBFSenktide8JBF-NK3-Senktide-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
31.82Consensusgi_apelinOrthosteric Ligand7W0P-Apelin-Elabela-Gi1/&β;1/&γ;2 7W0M-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
31.82Consensusgo_ghrelinOrthosteric Ligand7W2Z-Ghrelin-Ghrelin-Go/&β;1/&γ;2
31.82Consensuslipid_onOrthosteric Ligandcannabinoid_on ffa_on gpr119_on leuko_on lpl_on prostanoid_on
31.82Consensusmc4_onOrthosteric Ligand7F53-MC4-Alpha-MSH-Gs/&β;1/&γ;2 7F55-MC4-Bremelanotide-Gs/&β;1/&γ;2 7PIV-MC4-Setmelanotide-Gs/&β;1/&γ;2 7F58-MC4-THIQ-Gs/&β;1/&γ;2 7F54-MC4-Afamelanotide-Gs/&β;1/&γ;2
31.82Consensusmotilin_onOrthosteric Ligand8IBV-Motilin-Motilin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IBU-Motilin-Erythromycin A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
31.82Consensusnk1_onOrthosteric Ligand8U26-NK1-Protachykinin-1-Gs/&β;1/&γ;2 7P00-NK1-Substance P-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
31.58Single5C1MBU725C1M-μ-BU72
31.58Single5IUAQ274563485IUA-A2A-Q27456348-Na
31.58Single6E67BI1671076E67-β2-BI167107-Gs (fused)
31.58Single6LPLZM2413856LPL-A2A-ZM241385-Na
31.58Single6S0QZM2413856S0Q-A2A-ZM241385
31.58Single6W2XPubChem 237279706W2X-GABAB1, GABAB2-PubChem 5311042-PubChem 23727970
31.58Single6WQAZM2413856WQA-A2A-ZM241385-Na
31.58Single6XBKCholesterol6XBK-SMO-Cholesterol-Gi1/&β;1/&γ;2
31.58Single7C4SS1P7C4S-S1P3-S1P
31.58Single7CFNINT-7777CFN-GPBA-INT-777-Gs/&β;1/&γ;2
31.58Single7CKXA776367CKX-D1-A77636-Gs/&β;1/&γ;2
31.58Single7EO2FTY720-P7EO2-S1P1-FTY720-P-Gi1/&β;1/&γ;2
31.58Single7EW3S1P7EW3-S1P3-S1P-Gi1/&β;1/&γ;2
31.58Single7LD3Adenosine7LD3-A1-Adenosine-PubChem 25263603-Gi2/&β;1/&γ;2
31.58Single7RM5ZM2413857RM5-A2A-ZM241385-Na
31.58Single7WC6LSD7WC6-5-HT2A-LSD
31.58Single7YXAONO-54306087YXA-S1P5-ONO-5430608
31.58Single8FYNZM2413858FYN-A2A-ZM241385-Na
31.58Single8ID9Eicosapentaenoic acid8ID9-FFA4 (GPR120)-Eicosapentaenoic acid-Gi1/&β;1/&γ;2
31.58Single8J6JGSK2560738J6J-HCA2-GSK256073-Gi1/&β;1/&γ;2
31.58Single8SZGCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-chim(NtGi1-Gq)/&β;1/&γ;2
31.58Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/&β;1/&γ;2
31.58Consensusa1_offOrthosteric Ligand5UEN-A1-DU172 5N2S-A1-PSB36
31.58Consensusa1_on_alloOrthosteric Ligand7LD3-A1-Adenosine-PubChem 25263603-Gi2/&β;1/&γ;2
31.58Consensusadrenergic_offOrthosteric Ligandbeta_off alpha_off
31.58Consensusbeta3_onOrthosteric Ligand7DH5-β3-Mirabegron-Gs/&β;1/&γ;2 7XJH-β3-Isoproterenol-Gs/&β;1/&γ;2
31.58Consensuscb2_onOrthosteric Ligand8GUS-CB2-HU-308-Gi1/&β;1/&γ;2 8GUT-CB2-LEI-102-Gi1/&β;1/&γ;2 8GUQ-CB2-Olorinab-Gi1/&β;1/&γ;2 8GUR-CB2-PubChem 104895-Gi1/&β;1/&γ;2 6KPF-CB2-PubChem 145915889-Gi1/&β;1/&γ;2 6PT0-CB2-WIN 55212-2-Gi1/&β;1/&γ;2
31.58Consensusd1_onOrthosteric Ligand7F0T-D1-Dopamine-Gs/&β;1/&γ;2 7CKY-D1-PW0464-Gs/&β;1/&γ;2 8IRR-D1-Rotigotine-Gs/&β;1/&γ;2 7JV5-D1-SKF81297-Gs/&β;1/&γ;2 7JVP-D1-SKF83959-Gs/&β;1/&γ;2 7X2D-D1-Tavapadon-Gs/&β;1/&γ;2 7JOZ-D1-VFP-Gs/&β;1/&γ;2 7CKX-D1-A77636-Gs/&β;1/&γ;2 7JVQ-D1-Apomorphine-Gs/&β;1/&γ;2
31.58Consensusrxfp4_onOrthosteric Ligand7YK7-RXFP4-DC591053-Gi2/&β;1/&γ;2 7YJ4-RXFP4-INSL5-Gi2/&β;1/&γ;2 7YK6-RXFP4-PubChem 138319674-Gi2/&β;1/&γ;2
31.25Single3V2WPubChem 518926453V2W-S1P1-PubChem 51892645
31.25Single6QNOAll-trans-retinal6QNO-Rhodopsin-All-trans-retinal-Gi1/&β;1/&γ;1
31.25Single8GH1Epinephrine8GH1-β2-Epinephrine
31.03Consensusgi_peptideOrthosteric Ligandgi_opioid gi_endothelin gi_formylpeptide gi_galanin gi_ghrelin gi_neuromedin gi_neurotensin gi_relaxin gi_neuropeptide gi_somatostatin gi_apelin gi_compl-peptide gi_cck
30.77Single7F6IKallidin7F6I-BK2-Kallidin-Gq/&β;1/&γ;2
30.77Single8HCQEndothelin-18HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
30.77Single8HCXEndothelin-18HCX-ETB-Endothelin-1-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
30.77Single8HK5Complement C58HK5-C5a1-Complement C5-Gi1/&β;1/&γ;2
30.77Consensuseta_onOrthosteric Ligand8HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
30.77Consensusgq_class-aOrthosteric Ligandgq_amine gq_peptide
30.43Single7F54Afamelanotide7F54-MC4-Afamelanotide-Gs/&β;1/&γ;2
30.43Single7L0RNeurotensin7L0R-NTS1-Neurotensin-Gi1/&β;1/&γ;1
30.43Single7RMHSubstance P7RMH-NK1-Substance P-Gs/&β;1/&γ;2
30.43Single8F7XNociceptin8F7X-NOP-Nociceptin-Gi1/&β;1/&γ;2
30.43Single8G59TUG-8918G59-FFA4 (GPR120)-TUG-891-Gi1/&β;1/&γ;2
30.43Single8J6RMK68928J6R-HCA2-MK6892-Gi1/&β;1/&γ;2
30.43Consensusgi_relaxinOrthosteric Ligand7YK7-RXFP4-DC591053-Gi2/&β;1/&γ;2 7YJ4-RXFP4-INSL5-Gi2/&β;1/&γ;2 7YK6-RXFP4-PubChem 138319674-Gi2/&β;1/&γ;2
30.43Consensusmop_offOrthosteric Ligand7UL4-μ-Alvimopan 4DKL-μ-Beta-funaltrexamine 8QOT-μ-Nanobody E
30.00Single3PDSHydroxybenzylisoproterenol3PDS-β2-Hydroxybenzylisoproterenol
30.00Single3ZEVNeurotensin3ZEV-NTS1-Neurotensin
30.00Single4BV0Neurotensin4BV0-NTS1-Neurotensin
30.00Single4DJHJDTic4DJH-κ-JDTic
30.00Single4LDLHydroxybenzylisoproterenol4LDL-β2-Hydroxybenzylisoproterenol
30.00Single4RWADIPP-NH24RWA-δ-DIPP-NH2
30.00Single5V56TC1145V56-SMO-TC114
30.00Single5XR8AM8415XR8-CB1-AM841
30.00Single6GT3Imaradenant6GT3-A2A-Imaradenant-Na
30.00Single6H7JIsoprenaline6H7J-β1-Isoprenaline
30.00Single6N48BI1671076N48-β2-BI167107-PubChem 138454256
30.00Single6NI3BI1671076NI3-β2-BI167107-Gs/&β;1/&γ;2
30.00Single6OS1TRV0266OS1-AT1-TRV026
30.00Single6W2XPubChem 237279706W2X-GABAB1, GABAB2-PubChem 5311042-PubChem 23727970
30.00Single7CKYPW04647CKY-D1-PW0464-Gs/&β;1/&γ;2
30.00Single7EW1Siponimod7EW1-S1P5-Siponimod-Gi1/&β;1/&γ;2
30.00Single7JJOIsoprenaline7JJO-β1-Isoprenaline-Gs/&β;1/&γ;2
30.00Single7JV5SKF812977JV5-D1-SKF81297-Gs/&β;1/&γ;2
30.00Single7L0PNeurotensin7L0P-NTS1-Neurotensin-Gi1/&β;1/&γ;1
30.00Single7L0QNeurotensin7L0Q-NTS1-Neurotensin-Gi1/&β;1/&γ;1
30.00Single7M8W15r-Methyl-Prostaglandin D27M8W-DP2-15r-Methyl-Prostaglandin D2-Na
30.00Single7PX4PSB-21137PX4-A2A-PSB-2113
30.00Single7SK6CXCL12_LRHQ7SK6-ACKR3-CXCL12_LRHQ
30.00Single7TUYGSK682753A7TUY-GPR183-GSK682753A
30.00Single7WV9PubMed 1048957WV9-CB1-PubMed 104895-ZCZ011-Gi2/&β;1/&γ;2
30.00Single7XTQR3997XTQ-GPBA-R399-Gs/&β;1/&γ;2
30.00Single8DZPmomSalB8DZP-κ-momSalB-Gi1/&β;1/&γ;2
30.00Single8FMZNeurotensin/neuromedin N8FMZ-NTS1-Neurotensin/neuromedin N-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
30.00Single8GUSHU-3088GUS-CB2-HU-308-Gi1/&β;1/&γ;2
30.00Single8HDOBAY 60-65838HDO-A2B-BAY 60-6583-Gs/&β;1/&γ;2
30.00Single8IHBGSK2560738IHB-HCA2-GSK256073-Gi1/&β;1/&γ;2
30.00Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
30.00Single8X16Piclidenoson8X16-A3A-Piclidenoson-Gi1/&β;1/&γ;2
30.00Consensusa2_onOrthosteric Liganda2a_on a2b_on
30.00Consensusa2b_onOrthosteric Ligand8HDP-A2B-Adenosine-Gs/&β;1/&γ;2 8HDO-A2B-BAY 60-6583-Gs/&β;1/&γ;2 7XY7-A2B-NECA-chim(NtGi1-Gs)/&β;1/&γ;2 7XY6-A2B-PubChem 11717831-chim(NtGi1-Gs)/&β;1/&γ;2
30.00Consensusadenosine_offOrthosteric Liganda1_off a2_off
30.00Consensusclass-a_offOrthosteric Ligandsensory_off amine_off lipid_off nucleotide_off peptide_off protein_off hcar_off
30.00Consensuscyslt1_off_ortoalloOrthosteric Ligand6RZ5-CysLT1-Zafirlukast-Na 6RZ4-CysLT1-Pranlukast-Na
30.00Consensusgi_endothelinOrthosteric Ligand8IY5-ETB-Endothelin-1-Gi1/&β;1/&γ;2 8HBD-ETB-IRL1620-Gi1/&β;1/&γ;2
30.00Consensusgs_adenosineOrthosteric Ligand8HDP-A2B-Adenosine-Gs/&β;1/&γ;2 8HDO-A2B-BAY 60-6583-Gs/&β;1/&γ;2 6GDG-A2A-NECA-Gs/&β;1/&γ;1 7XY7-A2B-NECA-chim(NtGi1-Gs)/&β;1/&γ;2 7XY6-A2B-PubChem 11717831-chim(NtGi1-Gs)/&β;1/&γ;2
30.00Consensusgs_dopamineOrthosteric Ligand7F0T-D1-Dopamine-Gs/&β;1/&γ;2 7CKX-D1-A77636-Gs/&β;1/&γ;2 7JVQ-D1-Apomorphine-Gs/&β;1/&γ;2 7CKY-D1-PW0464-Gs/&β;1/&γ;2 8IRV-D5-Rotigotine-chim(NtGi1-Gs)/&β;1/&γ;2 7JV5-D1-SKF81297-Gs/&β;1/&γ;2 7JVP-D1-SKF83959-Gs/&β;1/&γ;2 7X2D-D1-Tavapadon-Gs/&β;1/&γ;2 7JOZ-D1-VFP-Gs/&β;1/&γ;2
30.00Consensusgs_nucleotideOrthosteric Ligandgs_adenosine
30.00Consensuskop_offOrthosteric Ligand4DJH-κ-JDTic
30.00Consensusnts1_on_alloOrthosteric Ligand8JPB-NTS1-Neurotensin 8-13-PubChem 118610427; GDP; Mg-Gq; GRK2
30.00Consensusrelaxin_onOrthosteric Ligandrxfp4_on
30.00Consensuss1p3_onOrthosteric Ligand7EW3-S1P3-S1P-Gi1/&β;1/&γ;2 7EW4-S1P3-CYM5541-Gi1/&β;1/&γ;2 7EW2-S1P3-Fingolimod-Gi1/&β;1/&γ;2
30.00Consensuss1p5_onOrthosteric Ligand7EW1-S1P5-Siponimod-Gi1/&β;1/&γ;2
29.63Single4XT3Fractalkine4XT3-US28-Fractalkine
29.63Single5UIW5P7-CCL55UIW-CCR5-5P7-CCL5
29.63Single7SK4CXCL12_LRHQ7SK4-ACKR3-CXCL12_LRHQ
29.63Consensusccr5_offOrthosteric Ligand5UIW-CCR5-5P7-CCL5
29.63Consensuskop_onOrthosteric Ligand8F7W-κ-Dynorphin-Gi1/&β;1/&γ;2 8DZR-κ-GR89,696-chim(NtGi2-Gt3)/&β;1/&γ;2 8DZP-κ-momSalB-Gi1/&β;1/&γ;2 8FEG-κ-PRD_002517-Gi1/&β;1/&γ;2
29.41Single5K2DZM2413855K2D-A2A-ZM241385
29.41Single5OLHVipadenant5OLH-A2A-Vipadenant-Na
29.41Single6JZHZM2413856JZH-A2A-ZM241385-Na
29.41Single6PS7ZM2413856PS7-A2A-ZM241385-Na
29.41Single6TQ6PubChem 1457142836TQ6-OX1-PubChem 145714283
29.41Single8DU3PubChem 1055260648DU3-A2A-PubChem 105526064
29.41Single8EFOPZM218EFO-μ-PZM21-Gi1/&β;1/&γ;2
29.41Single8GGFEpinephrine8GGF-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
29.41Single8HMPPubChem 699214798HMP-GPR52-PubChem 69921479-Gs/&β;1/&γ;2
29.41Single8J20Valeric acid8J20-FFA3-Valeric acid-AR420626-Gi1/&β;1/&γ;2
29.41Consensusa2a_off_alloOrthosteric Ligand6ZDR-A2A-HMS1413f12-Na 6GT3-A2A-Imaradenant-Na 8CU7-A2A-LJ-4517-Na 5OLV-A2A-LUAA41063-Na 5N2R-A2A-PubChem 92460631; psb36-Na 5MZJ-A2A-Theophylline-Na 5OLO-A2A-Tozadenant-Na 5OLH-A2A-Vipadenant-Na 5NM4-A2A-ZM241385-Na 8GNE-A2A-KW-6356-Na 8JWZ-A2A-AB928-Na 5MZP-A2A-Caffeine-Na 8CIC-A2A-Etrumadenant-Na
29.41Consensuscxcr1_onOrthosteric Ligand8IC0-CXCR1-Interleukin-8-Gi1/&β;1/&γ;2
29.41Consensusffa3_on_alloOrthosteric Ligand8J20-FFA3-Valeric acid-AR420626-Gi1/&β;1/&γ;2
29.17Single3QAKUK-4320973QAK-A2A-UK-432097
29.17Single4IB4Ergotamine4IB4-5-HT2B-Ergotamine
29.17Single6DO1Angiotensin-Like peptide S1I86DO1-AT1-Angiotensin-Like peptide S1I8
29.17Single7C6A(Sar1,Ile8)-Angiotensin II7C6A-AT2-(Sar1,Ile8)-Angiotensin II
29.17Single7CUMPhospholipid7CUM-GABAB1, GABAB2-CGP54626-Phospholipid
29.17Single7PIUSetmelanotide7PIU-MC4-Setmelanotide-Gs/&β;1/&γ;2
29.17Single7PIVSetmelanotide7PIV-MC4-Setmelanotide-Gs/&β;1/&γ;2
29.17Single7RKMFractalkine7RKM-US28-Fractalkine-Gi1/&β;1/&γ;2
29.17Single7XMSSomatostatin-147XMS-SST4-Somatostatin-14-Gi1/&β;1/&γ;2
29.17Single8IBVMotilin8IBV-Motilin-Motilin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
29.03Single8U1UCCL18U1U-CCR8-CCL1-Gi1/&β;1/&γ;2
28.57Single4GRVNeurotensin 8-134GRV-NTS1-Neurotensin 8-13
28.57Single4PY02MeSATP4PY0-P2Y12-2MeSATP
28.57Single4XEENeurotensin4XEE-NTS1-Neurotensin
28.57Single4XESNeurotensin4XES-NTS1-Neurotensin
28.57Single6MXTSalmeterol6MXT-β2-Salmeterol
28.57Single6OS2TRV0266OS2-AT1-TRV026
28.57Single6OSAJMV4496OSA-NTS1-JMV449-Gi1/&β;1/&γ;2
28.57Single6TKOArformoterol6TKO-β1-Arformoterol-Arrestin2
28.57Single7DH5Mirabegron7DH5-β3-Mirabegron-Gs/&β;1/&γ;2
28.57Single7EO4BAF3127EO4-S1P1-BAF312-Gi1/&β;1/&γ;2
28.57Single7EVYSiponimod7EVY-S1P1-Siponimod-Gi1/&β;1/&γ;2
28.57Single7L0SNeurotensin7L0S-NTS1-Neurotensin-Gi1/&β;1/γ1
28.57Single7L1VPubChem 1554910097L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
28.57Single7T6BS1P7T6B-S1P2-S1P-chim(NtGi1L-G13)/&β;1/&γ;2
28.57Single7W0NElabela7W0N-Apelin-Elabela-Gi1/&β;1/&γ;2
28.57Single7XY7NECA7XY7-A2B-NECA-chim(NtGi1-Gs)/&β;1/&γ;2
28.57Single8HK2C3a anaphylatoxin8HK2-C3aB-C3a anaphylatoxin-Gi1/&β;1/&γ;2
28.57Single8IBUErythromycin A8IBU-Motilin-Erythromycin A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
28.57Single8JWYPubChem 1684517108JWY-A2A-PubChem 168451710
28.57Single8U26Protachykinin-18U26-NK1-Protachykinin-1-Gs/&β;1/&γ;2
28.57Single8WRBLysophosphatidylserine8WRB-GPR34-Lysophosphatidylserine-Gi1/&β;1/&γ;2
28.57Consensuscannabinoid_offOrthosteric Ligandcb1_off cb2_off
28.57Consensuscannabinoid_onOrthosteric Ligandcb1_on cb2_on
28.57Consensuscb1_onOrthosteric Ligand8GHV-CB1-PubChem 145964903-Gi1/&β;1/&γ;2 6KPG-CB1-AM841-Gi1/&β;1/&γ;2 6N4B-CB1-MDMB-Fubinaca-Gi1/&β;1/&γ;2
28.57Consensusccr8_onOrthosteric Ligand8U1U-CCR8-CCL1-Gi1/&β;1/&γ;2
28.57Consensuschemokine_offOrthosteric Ligandcxcr_off
28.57Consensuscxcr4_offOrthosteric Ligand4RWS-CXCR4-vMIP-II
28.57Consensuscxcr_offOrthosteric Ligandcxcr4_off
28.57Consensusdp2_offOrthosteric Ligand6D27-DP2-CAY10471 6D26-DP2-Fevipiprant
28.57Consensusdp_offOrthosteric Liganddp2_off
28.57Consensusetb_onOrthosteric Ligand8HCX-ETB-Endothelin-1-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8HBD-ETB-IRL1620-Gi1/&β;1/&γ;2
28.57Consensusgi_cannabinoidOrthosteric Ligand8GUS-CB2-HU-308-Gi1/&β;1/&γ;2 8GUT-CB2-LEI-102-Gi1/&β;1/&γ;2 8GUQ-CB2-Olorinab-Gi1/&β;1/&γ;2 8GUR-CB2-PubChem 104895-Gi1/&β;1/&γ;2 6KPF-CB2-PubChem 145915889-Gi1/&β;1/&γ;2 6PT0-CB2-WIN 55212-2-Gi1/&β;1/&γ;2 6KPG-CB1-AM841-Gi1/&β;1/&γ;2 6N4B-CB1-MDMB-Fubinaca-Gi1/&β;1/&γ;2 8GHV-CB1-PubChem 145964903-Gi1/&β;1/&γ;2
28.57Consensusgo_5htOrthosteric Ligand6G79-5-HT1B-Donitriptan-Go/&β;1/&γ;2 7UM5-5-HT5A-5-CT-chim(NtGi1-Go)/&β;1/&γ;2 7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/&β;1/&γ;2 7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/&β;1/&γ;2
28.57Consensusgs_bileacidOrthosteric Ligand7CFN-GPBA-INT-777-Gs/&β;1/&γ;2 7CFM-GPBA-P395-Gs/&β;1/&γ;2 7XTQ-GPBA-R399-Gs/&β;1/&γ;2
28.57Consensusgs_steroidOrthosteric Ligandgs_bileacid
28.57Consensusleuko_offOrthosteric Ligandblt_off cyslt_off
28.57Consensusnts1_onOrthosteric Ligand6OS9-NTS1-JMV449-Gi1/&β;1/&γ;2
28.57Consensusnts_onOrthosteric Ligandnts1_on
28.57Consensuspeptide_offOrthosteric Ligandopioid_off angiotensin_off bombesin_off cck_off endothelin_off ghrelin_off npy_off nts_off orexin_off vasopressin-ot_off tachykinin_off sst_off
28.57Consensuss1p_onOrthosteric Ligands1p3_on s1p5_on s1p1_on s1p2_on
28.12Single7X9ANeuropeptide Y7X9A-Y1-Neuropeptide Y-Gi1/&β;1/&γ;2
28.12Consensusmc2_onOrthosteric Ligand8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/&β;1/&γ;2; MRAP1
28.12Consensusnpy1_onOrthosteric Ligand7X9A-Y1-Neuropeptide Y-Gi1/&β;1/&γ;2
28.00Single6PT2KGCHM076PT2-δ-KGCHM07
28.00Single7XOUCholecystokinin-87XOU-CCKA-Cholecystokinin-8-Gs/&β;1/&γ;2
28.00Consensuscx3cr1_onOrthosteric Ligand7XBX-CX3CR1-CX3CL1-Gi1/&β;1/&γ;2
28.00Consensusgo_peptideOrthosteric Ligandgo_opioid go_ghrelin go_compl-peptide go_galanin go_vasopressin
28.00Consensusgs_motilinOrthosteric Ligand8IBV-Motilin-Motilin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IBU-Motilin-Erythromycin A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
28.00Consensusgs_tachykininOrthosteric Ligand8U26-NK1-Protachykinin-1-Gs/&β;1/&γ;2 7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7P00-NK1-Substance P-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
28.00Consensusmc5_onOrthosteric Ligand8INR-MC5-Alpha-MSH-Ca-chim(NtGi1-Gs)/&β;1/&γ;2 8IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
28.00Consensustachykinin_onOrthosteric Ligandnk1_on nk2_on
27.78Single3REYPubChem 56973REY-A2A-PubChem 5697
27.78Single4DKLBeta-funaltrexamine4DKL-μ-Beta-funaltrexamine
27.78Single5IU7Q274563465IU7-A2A-Q27456346-Na
27.78Single5JTBZM2413855JTB-A2A-ZM241385
27.78Single5NLXZM2413855NLX-A2A-ZM241385-Na
27.78Single6DS0Ly2660976DS0-5-HT2B-Ly266097
27.78Single6FK8PubChem 1324730356FK8-Rhodopsin-PubChem 132473035
27.78Single6MH8ZM2413856MH8-A2A-ZM241385
27.78Single6VI4JDTic6VI4-κ-JDTic
27.78Single6ZDRHMS1413f126ZDR-A2A-HMS1413f12-Na
27.78Single7C2EPubChem 1490507997C2E-GLP-1-PubChem 149050799-Gs/&β;1/&γ;2
27.78Single7JOZVFP7JOZ-D1-VFP-Gs/&β;1/&γ;2
27.78Single7T32ZM2413857T32-A2A-ZM241385
27.78Single8K4NVF08K4N-GPR34-VF0-Gi1/&β;1/&γ;2
27.78Single8T3VDHA8T3V-FFA1-DHA-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
27.78Single8UO2Epinephrine8UO2-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
27.78Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
27.78Consensus5ht5_onOrthosteric Ligand5ht5a_on
27.78Consensus5ht5a_onOrthosteric Ligand7UM5-5-HT5A-5-CT-chim(NtGi1-Go)/&β;1/&γ;2 7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/&β;1/&γ;2 7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/&β;1/&γ;2
27.78Consensusox2_offOrthosteric Ligand6TPN-OX2-HTL6641 7XRR-OX2-Lemborexant
27.27Single2YCZIodocyanopindolol2YCZ-β1-Iodocyanopindolol
27.27Single4BUONeurotensin4BUO-NTS1-Neurotensin
27.27Single5TUDErgotamine5TUD-5-HT2B-Ergotamine
27.27Single5TZYMK8666; PubChem 1270535975TZY-FFA1 (GPR40)-MK8666; PubChem 127053597
27.27Single6BQGErgotamine6BQG-5-HT2C-Ergotamine
27.27Single6G79Donitriptan6G79-5-HT1B-Donitriptan-Go/&β;1/&γ;2
27.27Single6H7LDobutamine6H7L-β1-Dobutamine
27.27Single6IBLArformoterol6IBL-β1-Arformoterol
27.27Single6OS9JMV4496OS9-NTS1-JMV449-Gi1/&β;1/&γ;2
27.27Single7EZCUKA7EZC-A2A-UKA
27.27Single7JVRBromoergocryptine7JVR-D2-Bromoergocryptine-Gi1/&β;1/&γ;2
27.27Single7MTSADX551647MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/&β;1/&γ;2
27.27Single7Y65C5a peptide7Y65-C5a1-C5a peptide-Gi1/&β;1/&γ;2
27.27Single8ID8TUG-8918ID8-FFA4 (GPR120)-TUG-891-Gi1/&β;1/&γ;2
27.27Consensusbileacid_onOrthosteric Ligand7CFN-GPBA-INT-777-Gs/&β;1/&γ;2 7CFM-GPBA-P395-Gs/&β;1/&γ;2 7XTQ-GPBA-R399-Gs/&β;1/&γ;2
27.27Consensusc5a1_off_ortoalloOrthosteric Ligand6C1Q-C5a1-PMX53-NDT9513727 6C1R-C5a1-PMX53-Avacopan; Na
27.27Consensussteroid_onOrthosteric Ligandbileacid_on
26.92Single5WB2CX3CL1.355WB2-US28-CX3CL1.35
26.92Single6JODAngiotensin II6JOD-AT2-Angiotensin II
26.92Single6WI9Secretin6WI9-Secretin-Secretin-Gs/&β;1/&γ;2
26.92Single7DW9Acyclovir triphosphate7DW9-V2-Acyclovir triphosphate-chim(NtGi1-Gs)/&β;1/&γ;2
26.92Single7W40Bombesin7W40-BB2-Bombesin-chim(NtGi1L-Gq)/&β;1/&γ;2
26.92Single7YONPeptide YY(3-36)7YON-Y2-Peptide YY(3-36)-Gi1/&β;1/&γ;2
26.92Single8J6IMK68928J6I-HCA2-MK6892-Gi1/&β;1/&γ;2
26.92Consensusbk2_onOrthosteric Ligand7F2O-BK2-Bradykinin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7F6I-BK2-Kallidin-Gq/&β;1/&γ;2
26.92Consensusv2_onOrthosteric Ligand7DW9-V2-Acyclovir triphosphate-chim(NtGi1-Gs)/&β;1/&γ;2
26.67Single3RFMCaffeine3RFM-A2A-Caffeine
26.67Single6OT025(S)-Epoxycholesterol6OT0-SMO-25(S)-Epoxycholesterol-Gi1/&β;1/&γ;2
26.67Single8A2OTheophylline8A2O-A2A-Theophylline-Na
26.32Single2Y01Dobutamine2Y01-β1-Dobutamine
26.32Single2Y02Carmoterol2Y02-β1-Carmoterol
26.32Single2Y04Salbutamol2Y04-β1-Salbutamol
26.32Single2YCYCyanopindolol2YCY-β1-Cyanopindolol
26.32Single3EMLZM2413853EML-A2A-ZM241385
26.32Single4EJ4Naltrindole4EJ4-δ-Naltrindole
26.32Single5K2AZM2413855K2A-A2A-ZM241385-Na
26.32Single5VRAZM2413855VRA-A2A-ZM241385-Na
26.32Single5ZKPForopafant (SR27417)5ZKP-PAF-Foropafant (SR27417)
26.32Single6FK7PubChem 1324730346FK7-Rhodopsin-PubChem 132473034
26.32Single6FKCPubChem 1324730396FKC-Rhodopsin-PubChem 132473039
26.32Single6KPFPubChem 1459158896KPF-CB2-PubChem 145915889-Gi1/&β;1/&γ;2
26.32Single6PRZ(S)-Alprenolol6PRZ-β2-(S)-Alprenolol
26.32Single6S0LZM2413856S0L-A2A-ZM241385
26.32Single7EPFNAM5977EPF-mGlu2; mGlu2-NAM597
26.32Single7JVQApomorphine7JVQ-D1-Apomorphine-Gs/&β;1/&γ;2
26.32Single7LCKDanuglipron7LCK-GLP-1-Danuglipron
26.32Single7LJCPubChem 867641037LJC-D1-PubChem 86764103-Mevidalen-Gs/&β;1/&γ;2
26.32Single7PP1Selatogrel7PP1-P2Y12-Selatogrel
26.32Single7S0GIsoprenaline7S0G-β1-Isoprenaline-chim(Gi1-CtGs)/&β;1/&γ;2
26.32Single7S15PubChem 1346112237S15-GLP-1-PubChem 134611223
26.32Single7SQOTAK-9257SQO-OX2-TAK-925-Gi1/&β;1/&γ;2
26.32Single7UL4Alvimopan7UL4-μ-Alvimopan
26.32Single7UM6Lisuride7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/&β;1/&γ;2
26.32Single7VIES1P7VIE-S1P1-S1P-Gi1/&β;1/&γ;2
26.32Single7VIF(S)-FTY720-P7VIF-S1P1-(S)-FTY720-P-Gi1/&β;1/&γ;2
26.32Single7XJHIsoproterenol7XJH-β3-Isoproterenol-Gs/&β;1/&γ;2
26.32Single8CU6LJ-45178CU6-A2A-LJ-4517
26.32Single8CU7LJ-45178CU7-A2A-LJ-4517-Na
26.32Single8EFQDamgo8EFQ-μ-Damgo-Gi1/&β;1/&γ;2
26.32Single8EJKTAK-8758EJK-FFA1 (GPR40)-TAK-875-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
26.32Single8GEHEpinephrine8GEH-β2-Epinephrine-Gs/&β;1/&γ;2
26.32Single8GGBEpinephrine8GGB-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
26.32Single8I7VAcipimox8I7V-HCA2-Acipimox-Gi1/&β;1/&γ;2
26.32Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/&β;1/&γ;2
26.32Consensusadenosine_onOrthosteric Liganda1_on a2_on
26.32Consensusalpha_offOrthosteric Ligandalpha1_off alpha2_off
26.32Consensuscb1_on_alloOrthosteric Ligand7WV9-CB1-PubMed 104895-ZCZ011-Gi2/&β;1/&γ;2
26.32Consensusdop_offOrthosteric Ligand4EJ4-δ-Naltrindole
26.32Consensushca3_onOrthosteric Ligand8IHJ-HCA3-Acifran-Gi1/&β;1/&γ;2
26.32Consensusnucleotide_onOrthosteric Ligandadenosine_on
26.32Consensusp2y12_offOrthosteric Ligand4NTJ-P2Y12-AZD1283 7PP1-P2Y12-Selatogrel
26.09Single4UG2CGS216804UG2-A2A-CGS21680
26.09Single5WF6UK-4320975WF6-A2A-UK-432097
26.09Single5ZTYAM102575ZTY-CB2-AM10257
26.09Single6OMMWKYMVX6OMM-FPR2-ALX-WKYMVX-Gi1/&β;1/&γ;2
26.09Single6PT3DPI-2876PT3-δ-DPI-287
26.09Single6RZ6ONO-25703666RZ6-CysLT2-ONO-2570366
26.09Single7MTRADX551647MTR-mGlu2; mGlu2-Glutamate-ADX55164
26.09Single7S8LCortistatin-147S8L-MRGPRX2-Cortistatin-14-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
26.09Single8INRAlpha-MSH8INR-MC5-Alpha-MSH-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
26.09Single8SAI1-oleoyl-2-hydroxy-sn-glycero-3-phospho-L-serine8SAI-GPR34-1-oleoyl-2-hydroxy-sn-glycero-3-phospho-L-serine-Gi1/&β;1/&γ;2
26.09Single8X5YAstemizole8X5Y-H1-Astemizole
26.09Consensusc3a_onOrthosteric Ligand8HK2-C3aB-C3a anaphylatoxin-Gi1/&β;1/&γ;2 8IA8-C3aB-E7 peptide-Gi1/&β;1/&γ;2 8J6D-C3aB-EP141-Go/&β;1/&γ;2 8I95-C3aB-EP54-Go/&β;1/&γ;2
26.09Consensuscb2_offOrthosteric Ligand5ZTY-CB2-AM10257
25.93Single7F9YGhrelin-287F9Y-Ghrelin-Ghrelin-28-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
25.93Single7KH0Acyclovir triphosphate7KH0-V2-Acyclovir triphosphate-chim(NtGi1-Gs)/&β;1/&γ;2
25.93Single7XATSomatostatin-147XAT-SST2-Somatostatin-14-Gi1/&β;1/&γ;2
25.93Single8E3ZVIP8E3Z-VPAC1-VIP-Gs/&β;1/&γ;2
25.93Consensusgs_melanocortinOrthosteric Ligand7F4D-MC1-Alpha-MSH-chim(NtGi1-Gs)/&β;1/&γ;2 7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/&β;1/&γ;2 7F54-MC4-Afamelanotide-Gs/&β;1/&γ;2 7F53-MC4-Alpha-MSH-Gs/&β;1/&γ;2 7F55-MC4-Bremelanotide-Gs/&β;1/&γ;2 7PIV-MC4-Setmelanotide-Gs/&β;1/&γ;2 7F4I-MC1-SHU9119-chim(NtGi1-Gs)/&β;1/&γ;2 7F58-MC4-THIQ-Gs/&β;1/&γ;2
25.93Consensusmc1_onOrthosteric Ligand7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/&β;1/&γ;2 7F4D-MC1-Alpha-MSH-chim(NtGi1-Gs)/&β;1/&γ;2 7F4I-MC1-SHU9119-chim(NtGi1-Gs)/&β;1/&γ;2
25.00Single2Y00Dobutamine2Y00-β1-Dobutamine
25.00Single2Y03Isoprenaline2Y03-β1-Isoprenaline
25.00Single4IARErgotamine4IAR-5-HT1B-Ergotamine
25.00Single4JKVTaladegib (LY2940680)4JKV-SMO-Taladegib (LY2940680)
25.00Single4NTJAZD12834NTJ-P2Y12-AZD1283
25.00Single4PHUFasiglifam4PHU-FFA1 (GPR40)-Fasiglifam
25.00Single4XT1Fractalkine4XT1-US28-Fractalkine
25.00Single4ZJ8Suvorexant4ZJ8-OX1-Suvorexant
25.00Single5N2RPubChem 92460631; psb365N2R-A2A-PubChem 92460631; psb36-Na
25.00Single5N2SPSB365N2S-A1-PSB36
25.00Single5OM4PubChem 1355666095OM4-A2A-PubChem 135566609-Na
25.00Single5TVNLSD5TVN-5-HT2B-LSD
25.00Single5VBLApelin Mimetic Peptide Agonist5VBL-Apelin-Apelin Mimetic Peptide Agonist
25.00Single5X7D(S)-Carazolol5X7D-β2-(S)-Carazolol-PubChem 129318963
25.00Single5XPRBosentan5XPR-ETB-Bosentan
25.00Single6D32Cyclopamine6D32-SMO-Cyclopamine-Cyclopamine
25.00Single6GDGNECA6GDG-A2A-NECA-Gs/&β;1/&γ;1
25.00Single6KPCPubChem 1459158896KPC-CB2-PubChem 145915889
25.00Single6KUWPubChem 572132346KUW-α2c-PubChem 57213234
25.00Single6PS3(S)-Carvedilol6PS3-β2-(S)-Carvedilol
25.00Single6RZ4Pranlukast6RZ4-CysLT1-Pranlukast-Na
25.00Single6RZ5Zafirlukast6RZ5-CysLT1-Zafirlukast-Na
25.00Single6RZ8ONO-20803656RZ8-CysLT2-ONO-2080365
25.00Single6TO7Suvorexant6TO7-OX1-Suvorexant-Na
25.00Single6TP6Filorexant6TP6-OX1-Filorexant
25.00Single6WIVPubChem 52923113; PubChem 529246456WIV-GABAB1, GABAB2-PubChem 52923113; PubChem 52924645
25.00Single7BVQ(S)-Carazolol7BVQ-β1-(S)-Carazolol
25.00Single7BZ2Arformoterol7BZ2-β2-Arformoterol-Gs/&β;1/&γ;2
25.00Single7RGPTirzepatide7RGP-GLP-1-Tirzepatide-chim(NtGi1-Gs)/&β;1/&γ;2
25.00Single7S0FIsoprenaline7S0F-β1-Isoprenaline-Gi1/&β;1/&γ;2
25.00Single7SK3CXCL127SK3-ACKR3-CXCL12
25.00Single7T6UCGEN-855A7T6U-FPR2-ALX-CGEN-855A-Gi1/&β;1/&γ;2
25.00Single7VABNon-Acylated Tirzepatide7VAB-GIP-Non-Acylated Tirzepatide-chim(NtGi1-Gs)/&β;1/&γ;2
25.00Single7VUHJNJ-635330547VUH-GPR139-JNJ-63533054-chim(Gs-CtGq)/&β;1/&γ;2
25.00Single7VV4Cortistatin-147VV4-MRGPRX2-Cortistatin-14
25.00Single7WC5Psilocin7WC5-5-HT2A-Psilocin
25.00Single7XKAEpinephrine7XKA-β2-Epinephrine
25.00Single8DCRDobutamine8DCR-β1-Dobutamine-Gs/&β;1/&γ;2
25.00Single8DZRGR89,6968DZR-κ-GR89,696-chim(NtGi2-Gt3)/&β;1/&γ;2
25.00Single8EITDoconexent8EIT-FFA1 (GPR40)-Doconexent-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
25.00Single8FN1Neurotensin/neuromedin N8FN1-NTS1-Neurotensin/neuromedin N-chim(NtGi1-Go)/&β;1/&γ;2
25.00Single8GNEKW-63568GNE-A2A-KW-6356-Na
25.00Single8IHJAcifran8IHJ-HCA3-Acifran-Gi1/&β;1/&γ;2
25.00Single8IZ4Lysophosphatidylserine8IZ4-GPR34-Lysophosphatidylserine-Gi1/&β;1/&γ;2
25.00Single8JZZC5a-desArg8JZZ-C5a1-C5a-desArg-Go/&β;1/&γ;2
25.00Single8K8JFenofibrate8K8J-CB1-Fenofibrate-chim(Gs-CtGq)/&β;1/&γ;2
25.00Single8KFXLMD-0098KFX-CCR8-LMD-009-Gi1/&β;1/&γ;2
25.00Single8QOTNanobody E8QOT-μ-Nanobody E
25.00Single8U4OCXCL128U4O-CXCR4-CXCL12-Cholesterol-Gi1/&β;1/&γ;2
25.00Single8UNYEpinephrine8UNY-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
25.00Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
25.00Consensusa2a_onOrthosteric Ligand6GDG-A2A-NECA-Gs/&β;1/&γ;1
25.00Consensusalpha2c_offOrthosteric Ligand6KUW-α2c-PubChem 57213234
25.00Consensusbeta2_onOrthosteric Ligand3SN6-β2-BI167107-Gs/&β;1/&γ;2 7DHR-β2-Isoprenaline-Gs/&β;1/&γ;2 7BZ2-β2-Arformoterol-Gs/&β;1/&γ;2 7DHI-β2-Salbutamol-Gs/&β;1/&γ;2
25.00Consensusbeta_onOrthosteric Ligandbeta1_on beta2_on beta3_on
25.00Consensusbradykinin_onOrthosteric Ligandbk2_on bk1_on
25.00Consensusccr5_onOrthosteric Ligand7O7F-CCR5-(6P4)CCL5-Gi1/&β;1/&γ;1 7F1Q-CCR5-MIP-1a-Gi1/&β;1/&γ;2
25.00Consensusfpr-alx_onOrthosteric Ligandfpr1-alx_on fpr2-alx_on
25.00Consensusgi_adrenergicOrthosteric Ligand7S0F-β1-Isoprenaline-Gi1/&β;1/&γ;2 6K42-α2b-Dexmedetomidine-Gi1/&β;1/&γ;2
25.00Consensusgo_class-aOrthosteric Ligandgo_amine go_peptide go_protein
25.00Consensusgs_adrenergicOrthosteric Ligand3SN6-β2-BI167107-Gs/&β;1/&γ;2 7DHR-β2-Isoprenaline-Gs/&β;1/&γ;2 7DHI-β2-Salbutamol-Gs/&β;1/&γ;2 7XJH-β3-Isoproterenol-Gs/&β;1/&γ;2 7DH5-β3-Mirabegron-Gs/&β;1/&γ;2 7XJI-β3-Solabegron-Gs/&β;1/&γ;2 8THK-Alpha1A-A61603-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8THL-Alpha1A-Epinephrine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 7JJO-β1-Isoprenaline-Gs/&β;1/&γ;2 8DCR-β1-Dobutamine-Gs/&β;1/&γ;2 7BZ2-β2-Arformoterol-Gs/&β;1/&γ;2
25.00Consensusgs_vasopressin-otOrthosteric Ligand7RYC-OT-Oxytocin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 7DW9-V2-Acyclovir triphosphate-chim(NtGi1-Gs)/&β;1/&γ;2
25.00Consensusnop_onOrthosteric Ligand8F7X-NOP-Nociceptin-Gi1/&β;1/&γ;2
25.00Consensusnpy2_onOrthosteric Ligand7YOO-Y2-Neuropeptide Y-Gi1/&β;1/&γ;2 7YON-Y2-Peptide YY(3-36)-Gi1/&β;1/&γ;2
24.24Consensusgi_neuropeptideOrthosteric Ligand7YOO-Y2-Neuropeptide Y-Gi1/&β;1/&γ;2 7YON-Y2-Peptide YY(3-36)-Gi1/&β;1/&γ;2 7X9C-Y4-Pancreatic Hormone-Gi1/&β;1/&γ;2 7X9A-Y1-Neuropeptide Y-Gi1/&β;1/&γ;2
24.24Consensusnpy_onOrthosteric Ligandnpy2_on npy4_on npy1_on
24.14Single7WVYAmyloid-Beta427WVY-FPR2-ALX-Amyloid-Beta42-Gi2/&β;1/&γ;2
24.14Single7YOONeuropeptide Y7YOO-Y2-Neuropeptide Y-Gi1/&β;1/&γ;2
24.14Consensusgi_proteinOrthosteric Ligandgi_chemokine gi_chemerin
24.14Consensusgo_class-b1Orthosteric Ligandgo_crf
24.14Consensusgo_crfOrthosteric Ligand7TS0-CRF2-Urocortin-chim(NtGi1L-Go)/&β;1/&γ;2
24.00Single5XJM(Sar1,Ile8)-Angiotensin II5XJM-AT2-(Sar1,Ile8)-Angiotensin II
24.00Single6HLOAprepitant6HLO-NK1-Aprepitant
24.00Single7CUMPhospholipid7CUM-GABAB1, GABAB2-CGP54626-Phospholipid
24.00Single7W0NElabela7W0N-Apelin-Elabela-Gi1/&β;1/&γ;2
24.00Single7XBXCX3CL17XBX-CX3CR1-CX3CL1-Gi1/&β;1/&γ;2
24.00Consensusalpha1_offOrthosteric Ligandalpha1a_off alpha1b_off
24.00Consensuscx3cr_onOrthosteric Ligandcx3cr1_on
24.00Consensusvasopressin-ot_onOrthosteric Ligandot_on v2_on
23.81Single2YDVNECA2YDV-A2A-NECA
23.81Single4IAQDihydroergotamine4IAQ-5-HT1B-Dihydroergotamine
23.81Single4UHRCGS216804UHR-A2A-CGS21680
23.81Single5A8E7-Methylcyanopindolol5A8E-β1-7-Methylcyanopindolol-Na
23.81Single5G53NECA5G53-A2A-NECA-Gs
23.81Single5TZR-5TZR-FFA1 (GPR40)-MK8666
23.81Single5V57TC1145V57-SMO-TC114
23.81Single5X93K-87945X93-ETB-K-8794
23.81Single6J21Aprepitant6J21-NK1-Aprepitant
23.81Single6UP7Neurotensin6UP7-NTS1-Neurotensin-Arrestin2
23.81Single6WGTLSD6WGT-5-HT2A-LSD
23.81Single7EW7PubChem 40774607EW7-S1P1-PubChem 4077460-Gi1/&β;1/&γ;2
23.81Single7F1TMIP-1a7F1T-CCR5-MIP-1a
23.81Single7S8MCortistatin-147S8M-MRGPRX2-Cortistatin-14-Gi1/&β;1/&γ;2
23.81Single7T2HLofentanil7T2H-μ-Lofentanil-Gi1/&β;1/&γ;2
23.81Single7U2LPubChem 1632012427U2L-μ-PubChem 163201242-Gi1/&β;1/&γ;2
23.81Single7WVXHumanin7WVX-FPR2-ALX-Humanin-Gi2/&β;1/&γ;2
23.81Single7XOWGastrin7XOW-CCKB-Gastrin-Gq/&β;1/&γ;2
23.81Single7XOXCholecystokinin-87XOX-CCKB-Cholecystokinin-8-Gq/&β;1/&γ;2
23.81Single7Y67C089 peptide7Y67-C5a1-C089 peptide-Gi1/&β;1/&γ;2
23.81Single8EF5Fentanyl8EF5-μ-Fentanyl-Gi1/&β;1/&γ;2
23.81Single8EFLSR170188EFL-μ-SR17018-Gi1/&β;1/&γ;2
23.81Single8IHHLUF62838IHH-HCA2-LUF6283-Gi1/&β;1/&γ;2
23.81Single8IRRRotigotine8IRR-D1-Rotigotine-Gs/&β;1/&γ;2
23.81Single8IRURotigotine8IRU-D4-Rotigotine-chim(NtGi1-Gs-CtGi1)/&β;1/&γ;2
23.81Single8JXVClozapine8JXV-H4-Clozapine-Gi1/&β;1/&γ;2
23.81Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/&β;1/&γ;2
23.81Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/&β;1/&γ;2
23.81Consensus5ht1b_onOrthosteric Ligand6G79-5-HT1B-Donitriptan-Go/&β;1/&γ;2
23.81Consensus5ht5_offOrthosteric Ligand5ht5a_off
23.81Consensusdopamine_offOrthosteric Ligandd3_off d2_off d4_off
23.81Consensusgi_dopamineOrthosteric Ligand8IRT-D3-Rotigotine-Gi1/&β;1/&γ;2 7JVR-D2-Bromoergocryptine-Gi1/&β;1/&γ;2 8IRS-D2-Rotigotine-Gi1/&β;1/&γ;2 7CMV-D3-PD128907-Gi1/&β;1/&γ;2 7CMU-D3-Pramipexole-Gi1/&β;1/&γ;2
23.81Consensusgs_ffaOrthosteric Ligand8EIT-FFA1 (GPR40)-Doconexent-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2 8EJC-FFA1 (GPR40)-TAK-875-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2 8H4K-FFA4-GW9508-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8T3V-FFA1-DHA-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8T3S-FFA2-Butyric acid-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8T3Q-FFA4-DHA-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8GD9-EP4-Rivenprost-Gs/&β;1/&γ;2 8GDA-EP4-L902688-Gs/&β;1/&γ;2 8GDB-EP4-PGE2-Gs/&β;1/&γ;2
23.81Consensuss1p2_onOrthosteric Ligand7T6B-S1P2-S1P-chim(NtGi1L-G13)/&β;1/&γ;2
23.81Consensussst4_onOrthosteric Ligand7XMT-SST4-J-2156-Gi1/&β;1/&γ;2
23.68Single8GY7Corticotropin8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/&β;1/&γ;2; MRAP1
23.53Single4O9RCyclopamine4O9R-SMO-Cyclopamine
23.53Single6HLLCP999946HLL-NK1-CP99994
23.53Single6PH7Nerol6PH7-Rhodopsin-Nerol-Gt(CT)
23.53Single6TP4ACT-4622066TP4-OX1-ACT-462206
23.53Single6TQ4PubChem 160468446TQ4-OX1-PubChem 16046844-Na
23.53Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
23.53Single7VDHC48/807VDH-MRGPRX2-C48/80-Gi1/&β;1/&γ;2
23.53Single7VUIJNJ-635330547VUI-GPR139-JNJ-63533054-GTP-chim(Gs-CtGq)/&β;1/&γ;2
23.53Single7XTASerotonin7XTA-5-HT4-Serotonin-Gi1/&β;1/&γ;2
23.53Single8EF6Morphine8EF6-μ-Morphine-Gi1/&β;1/&γ;2
23.53Single8GGCEpinephrine8GGC-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
23.53Single8GGEEpinephrine8GGE-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
23.53Single8H8JLodoxamide8H8J-GPR35-Lodoxamide-Ca-chim(NtGi1L-G13)/&β;1/&γ;2
23.53Consensusox1_off_alloOrthosteric Ligand6TOD-OX1-EMPA-Na 6TOS-OX1-GSK1059865-Na 6TQ4-OX1-PubChem 16046844-Na 6TO7-OX1-Suvorexant-Na
23.53Consensussmo_on_alloOrthosteric Ligand6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
23.33Single7VGXNeuropeptide Y7VGX-Y1-Neuropeptide Y-Gi1/&β;1/&γ;2
23.33Consensusgi_chemokineOrthosteric Ligand7VL9-CCR1-CCL15(26-92)-Gi1/&β;1/&γ;2 7XA3-CCR2-CCL2-Gi1/&β;1/&γ;2 7O7F-CCR5-(6P4)CCL5-Gi1/&β;1/&γ;1 7F1Q-CCR5-MIP-1a-Gi1/&β;1/&γ;2 7XBX-CX3CR1-CX3CL1-Gi1/&β;1/&γ;2 8IC0-CXCR1-Interleukin-8-Gi1/&β;1/&γ;2 6LFM-CXCR2-Interleukin-8-Gi1/&β;1/&γ;2 8U1U-CCR8-CCL1-Gi1/&β;1/&γ;2
23.33Consensusgs_peptideOrthosteric Ligandgs_cck gs_motilin gs_neuromedin gs_orexin gs_sst gs_tachykinin gs_trh gs_vasopressin-ot gs_bombesin gs_bradykinin gs_compl-peptide gs_endothelin gs_galanin gs_ghrelin gs_melanocortin
23.08Single5WF5UK-4320975WF5-A2A-UK-432097
23.08Single6W25SHU91196W25-MC4-SHU9119-Ca
23.08Single7F4HAfamelanotide7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/&β;1/&γ;2
23.08Single7XA3CCL27XA3-CCR2-CCL2-Gi1/&β;1/&γ;2
23.08Consensusccr2_onOrthosteric Ligand7XA3-CCR2-CCL2-Gi1/&β;1/&γ;2
23.08Consensusccr_offOrthosteric Ligandccr5_off ccr8_off
23.08Consensusgi_formylpeptideOrthosteric Ligand7VFX-FPR1-ALX-fMLF-Gi1/&β;1/&γ;2 7T6T-FPR1-ALX-fMLFII-Gi1/&β;1/&γ;2 7WVY-FPR2-ALX-Amyloid-Beta42-Gi2/&β;1/&γ;2 7T6U-FPR2-ALX-CGEN-855A-Gi1/&β;1/&γ;2 7WVV-FPR2-ALX-fMLFII-Gi2/&β;1/&γ;2 7WVW-FPR2-ALX-fMYFINILTL-Gi2/&β;1/&γ;2 7WVX-FPR2-ALX-Humanin-Gi2/&β;1/&γ;2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/&β;1/&γ;2 6OMM-FPR2-ALX-WKYMVX-Gi1/&β;1/&γ;2
22.73Single4AMIBucindolol4AMI-β1-Bucindolol
22.73Single4OR2FITM4OR2-mGlu1; mGlu1-FITM
22.73Single6C1RPMX536C1R-C5a1-PMX53-Avacopan; Na
22.73Single6CM4Risperidone6CM4-D2-Risperidone
22.73Single6H7N(S)-Xamoterol6H7N-β1-(S)-Xamoterol
22.73Single6H7OCyanopindolol6H7O-β1-Cyanopindolol
22.73Single6HLPNetupitant6HLP-NK1-Netupitant
22.73Single6RZ7ONO-25703666RZ7-CysLT2-ONO-2570366
22.73Single6VMSBromoergocryptine6VMS-D2-Bromoergocryptine-Gi1/&β;1/&γ;2
22.73Single6YVRNTS8-136YVR-NTS1-NTS8-13
22.73Single7EXDLasmiditan7EXD-5-HT1F-Lasmiditan-Gi1/&β;1/&γ;2
22.73Single7F55Bremelanotide7F55-MC4-Bremelanotide-Gs/&β;1/&γ;2
22.73Single7L1UOrexin7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
22.73Single7SUSPubChem 1227019087SUS-Apelin-PubChem 122701908
22.73Single7W0LPubChem 1227019087W0L-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
22.73Single7X1TTaltirelin7X1T-TRH-Taltirelin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
22.73Single7XMTJ-21567XMT-SST4-J-2156-Gi1/&β;1/&γ;2
22.73Single7XW5ML1097XW5-TSH-TSH-ML109-Gs/&β;1/&γ;2
22.73Single7XXI2MeSADP7XXI-P2Y12-2MeSADP-Gi2/&β;1/&γ;2
22.73Single7Y24Octreotide7Y24-SST2-Octreotide-Go/&β;1/&γ;2
22.73Single7Y66BM2137Y66-C5a1-BM213-Gi1/&β;1/&γ;2
22.73Single7YMJTamsulosin7YMJ-Alpha1A-Tamsulosin
22.73Single8IRSRotigotine8IRS-D2-Rotigotine-Gi1/&β;1/&γ;2
22.73Single8IRVRotigotine8IRV-D5-Rotigotine-chim(NtGi1-Gs)/&β;1/&γ;2
22.73Single8J22TUG-13758J22-FFA2-TUG-1375-Gi1/&β;1/&γ;2
22.73Single8J6DEP1418J6D-C3aB-EP141-Go/&β;1/&γ;2
22.73Single8JWZAB9288JWZ-A2A-AB928-Na
22.73Single8JZ7MK68928JZ7-HCA2-MK6892-Gi1/&β;1/&γ;2
22.73Single8T3QDHA8T3Q-FFA4-DHA-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
22.73Consensus5ht1f_onOrthosteric Ligand7EXD-5-HT1F-Lasmiditan-Gi1/&β;1/&γ;2
22.73Consensusbeta1_onOrthosteric Ligand7JJO-β1-Isoprenaline-Gs/&β;1/&γ;2 8DCR-β1-Dobutamine-Gs/&β;1/&γ;2
22.73Consensusgs_amineOrthosteric Ligandgs_5ht gs_adrenergic gs_dopamine gs_histamine gs_muscarinic gs_tar
22.73Consensustsh_on_alloOther Ligand7XW5-TSH-TSH-ML109-Gs/&β;1/&γ;2
22.58Single5VAIGLP-15VAI-GLP-1-GLP-1-Gs/&β;1/&γ;2
22.58Single6PB0Urocortin6PB0-CRF1-Urocortin-chim(NtGi1-Gs)/&β;1/&γ;2
22.58Single7TS0Urocortin7TS0-CRF2-Urocortin-chim(NtGi1L-Go)/&β;1/&γ;2
22.58Consensusbb2_onOrthosteric Ligand7W40-BB2-Bombesin-chim(NtGi1L-Gq)/&β;1/&γ;2 7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/&β;1/&γ;2
22.58Consensusgq_bombesinOrthosteric Ligand7W40-BB2-Bombesin-chim(NtGi1L-Gq)/&β;1/&γ;2 7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/&β;1/&γ;2
22.22Single2X72All-trans-retinal2X72-Rhodopsin-All-trans-retinal-Gt(CT)
22.22Single3VG9ZM2413853VG9-A2A-ZM241385-Antibody
22.22Single4BWBNeurotensin4BWB-NTS1-Neurotensin
22.22Single4QINSAG1.54QIN-SMO-SAG1.5
22.22Single5OLOTozadenant5OLO-A2A-Tozadenant-Na
22.22Single5WS3EMPA5WS3-OX2-EMPA
22.22Single5YQZGlucagon analogue5YQZ-Glucagon-Glucagon analogue
22.22Single6AKXA4R6AKX-CCR5-A4R
22.22Single6B73PubChem 1319551386B73-κ-PubChem 131955138
22.22Single6FKBPubChem 1324730386FKB-Rhodopsin-PubChem 132473038
22.22Single6KUXRS-799486KUX-α2a-RS-79948
22.22Single6MEOEnvelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd46MEO-CCR5-Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4
22.22Single6METEnvelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd46MET-CCR5-Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4
22.22Single6NWEOctyl Beta-D-Glucopyranoside6NWE-Rhodopsin-Octyl Beta-D-Glucopyranoside-Gt(CT)
22.22Single6O3CSAG21k6O3C-SMO-SAG21k-Cholesterol
22.22Single6OBA(S)-Alprenolol6OBA-β2-(S)-Alprenolol-GTPL11074
22.22Single6TODEMPA6TOD-OX1-EMPA-Na
22.22Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
22.22Single7F16TIP397F16-PTH2-TIP39-Gs/&β;1/&γ;2
22.22Single7F1ODopamine7F1O-D1-Dopamine-GDP; Mg-Gs/&β;1/&γ;2
22.22Single7FIMTirzepatide7FIM-GLP-1-Tirzepatide-Gs/&β;1/&γ;2
22.22Single7LD4Adenosine7LD4-A1-Adenosine-Gi2/&β;1/&γ;2
22.22Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
22.22Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
22.22Single7RYCOxytocin7RYC-OT-Oxytocin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
22.22Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
22.22Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
22.22Single7SRRLSD7SRR-5-HT2B-LSD-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
22.22Single7SRSLSD7SRS-5-HT2B-LSD-Arrestin2
22.22Single7T94PubChem 576644067T94-M2-Acetylcholine-PubChem 57664406-chim(NtGi1-Go)/&β;1/&γ;2
22.22Single7VIHCBP-3077VIH-S1P1-CBP-307-Gi1/&β;1/&γ;2
22.22Single7VUJJNJ-635330547VUJ-GPR139-JNJ-63533054-GDP-chim(Gs-CtGq)/&β;1/&γ;2
22.22Single7VV5C48/807VV5-MRGPRX2-C48/80-Gi1/&β;1/&γ;2
22.22Single7X2CFenoldopam7X2C-D1-Fenoldopam-Fenoldopam-Gs/&β;1/&γ;2
22.22Single7XRRLemborexant7XRR-OX2-Lemborexant
22.22Single8GNGIstradefylline8GNG-A2A-Istradefylline
22.22Single8HDPAdenosine8HDP-A2B-Adenosine-Gs/&β;1/&γ;2
22.22Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
22.22Single8SZGCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-chim(NtGi1-Gq)/&β;1/&γ;2
22.22Single8UO0Epinephrine8UO0-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
22.22Single8UO3Epinephrine8UO3-β2-Epinephrine-GTP; Mg-Gs/&β;1/&γ;2
22.22Single8WC4ZH86518WC4-TA1-ZH8651-chim(NtGi1-Gs)/&β;1/&γ;2
22.22Single8WCA2-Phenylethylamine8WCA-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/&β;1/&γ;2
22.22Consensusa1_onOrthosteric Ligand7LD4-A1-Adenosine-Gi2/&β;1/&γ;2
22.22Consensusalpha2_offOrthosteric Ligandalpha2a_off alpha2c_off
22.22Consensusalpha2a_offOrthosteric Ligand6KUX-α2a-RS-79948
22.22Consensusbeta2_off_alloOrthosteric Ligand6OBA-β2-(S)-Alprenolol-GTPL11074
22.22Consensusclass-f_offOrthosteric Ligandsmo_off
22.22Consensusgi_nucleotideOrthosteric Ligand7LD4-A1-Adenosine-Gi2/&β;1/&γ;2
22.22Consensusgi_somatostatinOrthosteric Ligand7XMR-SST2-Somatostatin-14-Gi1/&β;1/&γ;2 7XMT-SST4-J-2156-Gi1/&β;1/&γ;2 7XAU-SST2-Octreotide-Gi1/&β;1/&γ;2 7YAC-SST2-Paltusotine-Gi1/&β;1/&γ;2
22.22Consensusgo_class-bOrthosteric Ligandgo_class-b1 go_class-b2
22.22Consensusmglu_onOther Ligandmglu2_on mglu4_on
22.22Consensusnmur_onOrthosteric Ligandnmur1_on nmur2_on
22.22Consensusorexin_offOrthosteric Ligandox2_off ox1_off
21.88Single6LPBPACAP6LPB-PAC1-PACAP-Gs/&β;1/&γ;1
21.74Single4BVNCyanopindolol4BVN-β1-Cyanopindolol-Na
21.74Single4NC3Ergotamine4NC3-5-HT2B-Ergotamine
21.74Single4OR2FITM4OR2-mGlu1; mGlu1-FITM
21.74Single5UNHPubChem 1264564065UNH-AT2-PubChem 126456406
21.74Single6K1QIRL25006K1Q-ETB-IRL2500
21.74Single6RZ9ONO-27703726RZ9-CysLT2-ONO-2770372
21.74Single7LLLExendin-47LLL-GLP-1-Exendin-4-Gs/&β;1/&γ;2
21.74Single7UM4AS26747237UM4-5-HT5A-AS2674723
21.74Single7WVVfMLFII7WVV-FPR2-ALX-fMLFII-Gi2/&β;1/&γ;2
21.74Single7X8RBOC57X8R-GLP-1-BOC5-Gs/&β;1/&γ;2
21.74Single7XAVLanreotide7XAV-SST2-Lanreotide-Gi1/&β;1/&γ;2
21.74Single8E9X2-Deoxycytidine8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/&β;1/&γ;2
21.74Single8E9YPubChem 4466038E9Y-M3-PubChem 446603-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
21.74Single8FX5Xanomeline8FX5-M4-Xanomeline-Xanomeline-Gi1/&β;1/&γ;2
21.74Single8T3OTUG-8918T3O-FFA4-TUG-891-2Y5-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
21.74Consensus5ht5a_offOrthosteric Ligand7UM4-5-HT5A-AS2674723
21.74Consensusbeta1_off_alloOrthosteric Ligand4BVN-β1-Cyanopindolol-Na
21.74Consensuscckb_onOrthosteric Ligand7XOW-CCKB-Gastrin-Gq/&β;1/&γ;2 7F8W-CCKB-Gastrin-17-chim(NtGsL-Gq)/&β;1/&γ;2 8IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/&β;1/&γ;2
21.74Consensusclass-a_onOrthosteric Ligandsensory_on amine_on lipid_on nucleotide_on peptide_on protein_on hcar_on steroid_on melatonin_on
21.74Consensuscyslt2_offOrthosteric Ligand6RZ6-CysLT2-ONO-2570366 6RZ9-CysLT2-ONO-2770372 6RZ8-CysLT2-ONO-2080365
21.74Consensuscyslt_offOrthosteric Ligandcyslt2_off
21.74Consensusendothelin_offOrthosteric Ligandetb_off
21.74Consensusetb_offOrthosteric Ligand5XPR-ETB-Bosentan 6K1Q-ETB-IRL2500 5X93-ETB-K-8794
21.74Consensusffa4_on_alloOrthosteric Ligand8T3O-FFA4-TUG-891-2Y5-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
21.74Consensusgs_cckOrthosteric Ligand7MBX-CCKA-Cholecystokinin-8-Gs/&β;1/&γ;1 7XOV-CCKA-SR146131-Gs/&β;1/&γ;2
21.43Single6X18GLP-16X18-GLP-1-GLP-1-Gs/&β;1/&γ;2
21.43Single7X9BNeuropeptide Y7X9B-Y2-Neuropeptide Y-Gi1/&β;1/&γ;2
21.43Single7X9CPancreatic Hormone7X9C-Y4-Pancreatic Hormone-Gi1/&β;1/&γ;2
21.43Single7YKDChemerin-97YKD-CML1-Chemerin-9-Gi1/&β;1/&γ;2
21.43Single8E3YPACAP278E3Y-VPAC1-PACAP27-Gs/&β;1/&γ;2
21.43Single8IODPG-9018IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
21.43Consensusgs_bradykininOrthosteric Ligand7F2O-BK2-Bradykinin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7EIB-BK1-Des-Arg10-Kallidin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
21.43Consensusgs_ghrelinOrthosteric Ligand7F9Y-Ghrelin-Ghrelin-28-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
21.43Consensusgs_neuromedinOrthosteric Ligand7W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7W56-NMUR1-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7W57-NMUR2-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
21.05Single3UZCPubChem 1355666093UZC-A2A-PubChem 135566609
21.05Single4LDOL-Epinephrine4LDO-β2-L-Epinephrine
21.05Single4MBSMaraviroc4MBS-CCR5-Maraviroc
21.05Single4N6HNaltrindole4N6H-δ-Naltrindole-Na
21.05Single4ZJCSB-6740424ZJC-OX1-SB-674042
21.05Single5K2BZM2413855K2B-A2A-ZM241385-Na
21.05Single5TE3Octyl Beta-D-Glucopyranoside5TE3-Rhodopsin-Octyl Beta-D-Glucopyranoside
21.05Single5UVIZM2413855UVI-A2A-ZM241385
21.05Single6IQLL7458706IQL-D4-L745870
21.05Single6ME32-Phenylmelatonin6ME3-MT1-2-Phenylmelatonin
21.05Single6PELCitronellol6PEL-Rhodopsin-Citronellol-Gt(CT)
21.05Single6PS4ICI 118-5516PS4-β2-ICI 118-551
21.05Single6PS5(S)-Propranolol6PS5-β2-(S)-Propranolol
21.05Single6TOSGSK10598656TOS-OX1-GSK1059865-Na
21.05Single6TP3Nemorexant6TP3-OX1-Nemorexant
21.05Single6TPGEMPA6TPG-OX2-EMPA
21.05Single6TPNHTL66416TPN-OX2-HTL6641
21.05Single6V9SGTPL114036V9S-OX1-GTPL11403
21.05Single6WJCMuscarinic toxin 76WJC-M1-Atropine-Muscarinic toxin 7
21.05Single6XBLSAG6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
21.05Single6ZA8RTI-3a6ZA8-NTS1-RTI-3a
21.05Single7CKWFenoldopam7CKW-D1-Fenoldopam-Gs/&β;1/&γ;2
21.05Single7CKZDopamine7CKZ-D1-Dopamine-Mevidalen-Gs/&β;1/&γ;2
21.05Single7CMUPramipexole7CMU-D3-Pramipexole-Gi1/&β;1/&γ;2
21.05Single7F0TDopamine7F0T-D1-Dopamine-Gs/&β;1/&γ;2
21.05Single7F1ZDopamine7F1Z-D1-Dopamine-GDP-Gs/&β;1/&γ;2
21.05Single7F61PF-036547467F61-H3-PF-03654746-Cholesterol
21.05Single7RANPubChem 1645758477RAN-5-HT2A-PubChem 164575847-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
21.05Single7S8PMS471347S8P-MRGPRX4-MS47134-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
21.05Single7TRQVU04671547TRQ-M4-Iperoxo-VU0467154-Gi1/&β;1/&γ;2
21.05Single7UM7Methylergometrine7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/&β;1/&γ;2
21.05Single7VV6C48/807VV6-MRGPRX2-C48/80
21.05Single7XXH2MeSADP7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/&β;1/&γ;2
21.05Single7ZI0SAG7ZI0-SMO-SAG-Cholesterol
21.05Single8DWGML3828DWG-MRGPRX1-Proenkephalin-A-ML382-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
21.05Single8GDZEpinephrine8GDZ-β2-Epinephrine-Gs/&β;1/&γ;2
21.05Single8GEGEpinephrine8GEG-β2-Epinephrine-Gs/&β;1/&γ;2
21.05Single8GG5Epinephrine8GG5-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
21.05Single8GGKEpinephrine8GGK-β2-Epinephrine
21.05Single8GGMEpinephrine8GGM-β2-Epinephrine
21.05Single8GGPEpinephrine8GGP-β2-Epinephrine
21.05Single8GGQEpinephrine8GGQ-β2-Epinephrine
21.05Single8GGTEpinephrine8GGT-β2-Epinephrine
21.05Single8H4LDoconexent8H4L-FFA4-Doconexent-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
21.05Single8HQN9(S)-HODE8HQN-GPR132-9(S)-HODE-Gi1/&β;1/&γ;2
21.05Single8J6PNiacin8J6P-HCA2-Niacin-Compound 9n-Gi1/&β;1/&γ;2
21.05Single8JERAcipimox8JER-HCA2-Acipimox-Go/&β;1/&γ;2
21.05Single8JHNMMF8JHN-HCA2-MMF-Go/&β;1/&γ;2
21.05Single8JLQFenoldopam8JLQ-TA1-Fenoldopam-Gs/&β;1/&γ;2
21.05Single8K2WAMG4878K2W-CXCR3-AMG487
21.05Single8K5CAcipimox8K5C-HCA2-Acipimox
21.05Single8THLEpinephrine8THL-Alpha1A-Epinephrine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
21.05Single8UNZEpinephrine8UNZ-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
21.05Consensuscxcr2_onOrthosteric Ligand6LFM-CXCR2-Interleukin-8-Gi1/&β;1/&γ;2
21.05Consensuscxcr_onOrthosteric Ligandcxcr1_on cxcr2_on
21.05Consensusd1_on_alloOrthosteric Ligand7LJC-D1-PubChem 86764103-Mevidalen-Gs/&β;1/&γ;2 7CKZ-D1-Dopamine-Mevidalen-Gs/&β;1/&γ;2
21.05Consensusd3_onOrthosteric Ligand8IRT-D3-Rotigotine-Gi1/&β;1/&γ;2 7CMV-D3-PD128907-Gi1/&β;1/&γ;2 7CMU-D3-Pramipexole-Gi1/&β;1/&γ;2
21.05Consensusdop_off_alloOrthosteric Ligand4N6H-δ-Naltrindole-Na
21.05Consensusgi_class-fOrthosteric Ligandgi_frizzled
21.05Consensusgi_frizzledOrthosteric Ligand6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
21.05Consensusgs_tarOrthosteric Ligand8W88-TA1-SEP-363856-Gs/&β;1/&γ;2 8JLN-TA1-T1AM-Gs/&β;1/&γ;2 8JLO-TA1-Ulotaront-Gs/&β;1/&γ;2 8JLQ-TA1-Fenoldopam-Gs/&β;1/&γ;2 8JLP-TA1-Ralmitaront-Gs/&β;1/&γ;2 8WCA-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/&β;1/&γ;2 8WCB-TA1-Cyclohexylammonium ion-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8WC8-TA1-ZH8651-chim(NtGi1-Gs)/&β;1/&γ;2
21.05Consensush3_on_alloOrthosteric Ligand7F61-H3-PF-03654746-Cholesterol
21.05Consensushca_onOrthosteric Ligandhca2_on hca3_on
21.05Consensushcar_onOrthosteric Ligandhca_on
21.05Consensuslh_on_alloOther Ligand7FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/&β;1/&γ;2
21.05Consensusm1_off_alloOther Ligand6WJC-M1-Atropine-Muscarinic toxin 7
21.05Consensusox1_offOrthosteric Ligand6TOT-OX1-Lemborexant 6TP4-OX1-ACT-462206 6TP6-OX1-Filorexant 6V9S-OX1-GTPL11403 6TP3-OX1-Nemorexant 6TQ6-OX1-PubChem 145714283 6TQ7-OX1-SB-334867 6TQ9-OX1-SB-408124 4ZJC-OX1-SB-674042 4ZJ8-OX1-Suvorexant
20.83Single6XBJCholesterol6XBJ-SMO-Cholesterol-Gi1/&β;1/&γ;2
20.83Single7F2OBradykinin7F2O-BK2-Bradykinin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
20.83Single7F8WGastrin-177F8W-CCKB-Gastrin-17-chim(NtGsL-Gq)/&β;1/&γ;2
20.83Single7F9ZGHRP-67F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
20.83Single7SK9CCX6627SK9-ACKR3-CCX662
20.83Single7X1UTRH7X1U-TRH-TRH-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
20.83Single7X8SWB4-247X8S-GLP-1-WB4-24-Gs/&β;1/&γ;2
20.83Single8IA7Cholecystokinin-88IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/&β;1/&γ;2
20.83Single8IYHMK68928IYH-HCA2-MK6892-Go/&β;1/&γ;2
20.83Single8JLRA776368JLR-TA1-A77636-chim(NtGi1-Gs)/&β;1/&γ;2
20.83Single8XZFWN5618XZF-Apelin-WN561-Gi1/&β;1/&γ;2
20.83Consensuschemokine_onOrthosteric Ligandcxcr_on cx3cr_on
20.83Consensusclass-d_offOrthosteric Ligandste2_off
20.83Consensusfpr2-alx_onOrthosteric Ligand7WVY-FPR2-ALX-Amyloid-Beta42-Gi2/&β;1/&γ;2 7T6U-FPR2-ALX-CGEN-855A-Gi1/&β;1/&γ;2 7WVV-FPR2-ALX-fMLFII-Gi2/&β;1/&γ;2 7WVW-FPR2-ALX-fMYFINILTL-Gi2/&β;1/&γ;2 7WVX-FPR2-ALX-Humanin-Gi2/&β;1/&γ;2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/&β;1/&γ;2 6OMM-FPR2-ALX-WKYMVX-Gi1/&β;1/&γ;2
20.83Consensusgo_vasopressinOrthosteric Ligand7QVM-OT-Oxytocin-chim(NtGi1-Go-CtGq)/&β;1/&γ;2
20.83Consensusgq_cckOrthosteric Ligand8IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/&β;1/&γ;2 7F8W-CCKB-Gastrin-17-chim(NtGsL-Gq)/&β;1/&γ;2 7EZM-CCKA-Cholecystokinin-8-chim(NtGsL-Gq)/&β;1/&γ;2 7XOW-CCKB-Gastrin-Gq/&β;1/&γ;2
20.69Single7FIYTirzepatide7FIY-GIP-Tirzepatide-Gs/&β;1/&γ;2
20.69Single7RA3GIP7RA3-GIP-GIP-chim(NtGi1-Gs)/&β;1/&γ;2
20.69Single7W3ZGastrin Releasing Peptide7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/&β;1/&γ;2
20.69Single8E3XPACAP278E3X-PAC1-PACAP27-Gs/&β;1/&γ;2
20.69Single8H0PNMB308H0P-BB1-NMB30-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
20.69Single8JISPeptide-158JIS-GLP-1-Peptide-15-chim(NtGi1-Gs)/&β;1/&γ;2
20.69Consensusbb1_onOrthosteric Ligand8H0P-BB1-NMB30-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
20.69Consensusgi_neuromedinOrthosteric Ligand7XK8-NMUR2-Neuromedin-U-25-Gi1/&β;1/&γ;2
20.69Consensusnpy4_onOrthosteric Ligand7X9C-Y4-Pancreatic Hormone-Gi1/&β;1/&γ;2
20.59Consensuspth2_onOrthosteric Ligand7F16-PTH2-TIP39-Gs/&β;1/&γ;2
20.00Single2VT4Cyanopindolol2VT4-β1-Cyanopindolol
20.00Single3NY8ICI 118-5513NY8-β2-ICI 118-551
20.00Single3ZPQ4-(piperazin-1- yl)-1H-indole3ZPQ-β1-4-(piperazin-1- yl)-1H-indole-Na
20.00Single3ZPR4-methyl-2-(piperazin-1-yl)3ZPR-β1-4-methyl-2-(piperazin-1-yl)-Na
20.00Single4AMJ(S)-Carvedilol4AMJ-β1-(S)-Carvedilol
20.00Single4EA3PubChem 102965614EA3-NOP-PubChem 10296561
20.00Single4GBR(S)-Carazolol4GBR-β2-(S)-Carazolol
20.00Single4J4QOctyl Beta-D-Glucopyranoside4J4Q-Rhodopsin-Octyl Beta-D-Glucopyranoside-Gt(CT)
20.00Single4QKXPubChem 762106284QKX-β2-PubChem 76210628
20.00Single4X1HNonyl Beta-D-Glucopyranoside4X1H-Rhodopsin-Nonyl Beta-D-Glucopyranoside-Gt(CT)
20.00Single4ZUDOlmesartan4ZUD-AT1-Olmesartan
20.00Single5DHGPubChem 250014125DHG-NOP-PubChem 25001412
20.00Single5JQH(S)-Carazolol5JQH-β2-(S)-Carazolol
20.00Single5MZJTheophylline5MZJ-A2A-Theophylline-Na
20.00Single5OLZPubChem 1355666095OLZ-A2A-PubChem 135566609-Na
20.00Single5OM1PubChem 1355666095OM1-A2A-PubChem 135566609-Na
20.00Single5T04Neurotensin5T04-NTS1-Neurotensin
20.00Single5TGZAM65385TGZ-CB1-AM6538
20.00Single6D27CAY104716D27-DP2-CAY10471
20.00Single6DRXLisuride6DRX-5-HT2B-Lisuride
20.00Single6FKDPubChem 1373491836FKD-Rhodopsin-PubChem 137349183
20.00Single6GPSMK08126GPS-CCR2-MK0812
20.00Single6H7MSalbutamol6H7M-β1-Salbutamol
20.00Single6PS0(S)-Carazolol6PS0-β2-(S)-Carazolol
20.00Single6PS1Timolol6PS1-β2-Timolol
20.00Single6PS2(S)-Alprenolol6PS2-β2-(S)-Alprenolol
20.00Single6PS82-Phenylmelatonin6PS8-MT1-2-Phenylmelatonin
20.00Single6TOTLemborexant6TOT-OX1-Lemborexant
20.00Single6UVAAdrenomedullin-26UVA-CT Like (AM2)-Adrenomedullin-2-Gs/&β;1/&γ;2; RAMP3
20.00Single6VCBGLP-16VCB-GLP-1-GLP-1-LSN3160440-Gs/&β;1/&γ;2
20.00Single6X1ADanuglipron6X1A-GLP-1-Danuglipron-Gs/&β;1/&γ;2
20.00Single7BTSL-Epinephrine7BTS-β1-L-Epinephrine
20.00Single7BU6L-Norepinephrine7BU6-β1-L-Norepinephrine
20.00Single7CFMP3957CFM-GPBA-P395-Gs/&β;1/&γ;2
20.00Single7DB6Ramelteon7DB6-MT1-Ramelteon-Gi1/&β;1/&γ;2
20.00Single7DTYGIP7DTY-GIP-GIP-Gs/&β;1/&γ;2
20.00Single7F8XNN90567F8X-CCKA-NN9056
20.00Single7FIHOrg435537FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/&β;1/&γ;2
20.00Single7LCIDanuglipron7LCI-GLP-1-Danuglipron-Gs/&β;1/&γ;2
20.00Single7NA8PubChem 1780247NA8-Ghrelin-PubChem 178024-Gi1/&β;1/&γ;2
20.00Single7QA8Peptide7QA8-STE2-Peptide
20.00Single7QA8Peptide7QA8-STE2-Peptide
20.00Single7S1MEx4-D-Ala7S1M-GLP-1-Ex4-D-Ala-Gs/&β;1/&γ;2
20.00Single7SCGFH2107SCG-μ-FH210-Gi1/&β;1/&γ;2
20.00Single7T2GMitragynine pseudoindoxyl7T2G-μ-Mitragynine pseudoindoxyl-Gi1/&β;1/&γ;2
20.00Single7T6VfMLFII7T6V-FPR2-ALX-fMLFII-Gi1/&β;1/&γ;2
20.00Single7VGZRemalteon7VGZ-MT1-Remalteon-Gi1/&β;1/&γ;2
20.00Single7VKTLTB47VKT-BLT1-LTB4-Gi1/&β;1/&γ;2
20.00Single7W53Neuromedin-U-257W53-NMUR1-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
20.00Single7WC7Lisuride7WC7-5-HT2A-Lisuride
20.00Single7WKDTRH7WKD-TRH-TRH-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
20.00Single7X2CFenoldopam7X2C-D1-Fenoldopam-Fenoldopam-Gs/&β;1/&γ;2
20.00Single7XK8Neuromedin-U-257XK8-NMUR2-Neuromedin-U-25-Gi1/&β;1/&γ;2
20.00Single7XTC5-CT7XTC-5-HT7-5-CT-Gs/&β;1/&γ;2
20.00Single8CICEtrumadenant8CIC-A2A-Etrumadenant-Na
20.00Single8DZSGR89,6968DZS-κ-GR89,696-chim(NtGi2-Gz)/&β;1/&γ;2
20.00Single8EJCTAK-8758EJC-FFA1 (GPR40)-TAK-875-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
20.00Single8FU6Glucagon derivative ZP37808FU6-Glucagon-Glucagon derivative ZP3780-Gs/&β;1/&γ;2
20.00Single8GE3Epinephrine8GE3-β2-Epinephrine-Gs/&β;1/&γ;2
20.00Single8GEBEpinephrine8GEB-β2-Epinephrine-Gs/&β;1/&γ;2
20.00Single8GEEEpinephrine8GEE-β2-Epinephrine-Gs/&β;1/&γ;2
20.00Single8GFWEpinephrine8GFW-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
20.00Single8GFXEpinephrine8GFX-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
20.00Single8GFYEpinephrine8GFY-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
20.00Single8GFZEpinephrine8GFZ-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
20.00Single8GG0Epinephrine8GG0-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
20.00Single8GG1Epinephrine8GG1-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
20.00Single8GG2Epinephrine8GG2-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
20.00Single8GG6Epinephrine8GG6-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
20.00Single8GGJEpinephrine8GGJ-β2-Epinephrine
20.00Single8GGNEpinephrine8GGN-β2-Epinephrine
20.00Single8GGOEpinephrine8GGO-β2-Epinephrine
20.00Single8GGUEpinephrine8GGU-β2-Epinephrine
20.00Single8IRTRotigotine8IRT-D3-Rotigotine-Gi1/&β;1/&γ;2
20.00Single8IZBLysophosphatidylserine8IZB-GPR174-Lysophosphatidylserine-Gs/&β;1/&γ;2
20.00Single8JIINiacin8JII-HCA2-Niacin-Compound 9n-Gi1/&β;1/&γ;2
20.00Single8JLZST19368JLZ-5-HT6-ST1936-Gs/&β;1/&γ;2
20.00Single8KFYZK-7563268KFY-CCR8-ZK-756326-Gi1/&β;1/&γ;2
20.00Single8PWNTheophylline8PWN-A2A-Theophylline
20.00Single8UNMEpinephrine8UNM-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
20.00Single8UNNEpinephrine8UNN-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
20.00Single8UNPEpinephrine8UNP-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
20.00Single8UO4Epinephrine8UO4-β2-Epinephrine-GTP; Mg-Gs/&β;1/&γ;2
20.00Single8W87METH8W87-TA1-METH-chim(NtGi1L-Gs)/&β;1/&γ;2
20.00Consensus5ht6_onOrthosteric Ligand7XTB-5-HT6-Serotonin-Gs/&β;1/&γ;2 8JLZ-5-HT6-ST1936-Gs/&β;1/&γ;2
20.00Consensus5ht7_onOrthosteric Ligand7XTC-5-HT7-5-CT-Gs/&β;1/&γ;2
20.00Consensusadrenergic_onOrthosteric Ligandbeta_on alpha_on
20.00Consensusalpha2_onOrthosteric Ligandalpha2a_on alpha2b_on
20.00Consensusalpha_onOrthosteric Ligandalpha1_on alpha2_on
20.00Consensusblt1_onOrthosteric Ligand7VKT-BLT1-LTB4-Gi1/&β;1/&γ;2
20.00Consensusblt_onOrthosteric Ligandblt1_on
20.00Consensusccr_onOrthosteric Ligandccr5_on ccr6_on ccr1_on ccr2_on ccr8_on
20.00Consensusclass-d_offOrthosteric Ligandste2_off
20.00Consensusd5_onOrthosteric Ligand8IRV-D5-Rotigotine-chim(NtGi1-Gs)/&β;1/&γ;2
20.00Consensusdopamine_onOrthosteric Ligandd3_on d2_on d5_on d1_on
20.00Consensusffa1_onOrthosteric Ligand8EIT-FFA1 (GPR40)-Doconexent-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2 8EJC-FFA1 (GPR40)-TAK-875-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2 8T3V-FFA1-DHA-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
20.00Consensusgi_hcaOrthosteric Ligand8H2G-HCA2-Niacin-Gi1/&β;1/&γ;2 8IHJ-HCA3-Acifran-Gi1/&β;1/&γ;2 8IHI-HCA2-Acifran-Gi1/&β;1/&γ;2 8IHB-HCA2-GSK256073-Gi1/&β;1/&γ;2 8IHH-HCA2-LUF6283-Gi1/&β;1/&γ;2 8IHF-HCA2-MK6892-Gi1/&β;1/&γ;2 8JIM-HCA2-MMF-Gi1/&β;1/&γ;2 8IJB-HCA2-Acipimox-Gi1/&β;1/&γ;2 8IJD-HCA2-MK6892-Gi1/&β;1/&γ;2
20.00Consensusgi_hcarOrthosteric Ligandgi_hca
20.00Consensusgi_leukotrieneOrthosteric Ligand7VKT-BLT1-LTB4-Gi1/&β;1/&γ;2
20.00Consensusgs_class-bOrthosteric Ligandgs_class-b1 gs_class-b2
20.00Consensushca2_onOrthosteric Ligand8H2G-HCA2-Niacin-Gi1/&β;1/&γ;2 8IHI-HCA2-Acifran-Gi1/&β;1/&γ;2 8IHH-HCA2-LUF6283-Gi1/&β;1/&γ;2 8IHF-HCA2-MK6892-Gi1/&β;1/&γ;2 8JHY-HCA2-Compound 9n-Gi1/&β;1/&γ;2 8IHB-HCA2-GSK256073-Gi1/&β;1/&γ;2 8JIM-HCA2-MMF-Gi1/&β;1/&γ;2 8IJB-HCA2-Acipimox-Gi1/&β;1/&γ;2 8IJD-HCA2-MK6892-Gi1/&β;1/&γ;2 8J6J-HCA2-GSK256073-Gi1/&β;1/&γ;2
20.00Consensusleuko_onOrthosteric Ligandblt_on
20.00Consensuspaf_offOrthosteric Ligand5ZKQ-PAF-ABT-491 5ZKP-PAF-Foropafant (SR27417)
20.00Consensusprotein_offOrthosteric Ligandccr_off chemokine_off gnrh_off
20.00Consensuspth_onOrthosteric Ligandpth1_on pth2_on
20.00Consensussst_onOrthosteric Ligandsst2_on sst4_on
20.00Consensustar_onOrthosteric Ligandta1_on
19.44Consensusct_onOrthosteric Ligand7TYL-CT-Amylin-Gs/&β;1/&γ;2 7TYN-CT-Calcitonin-1-Gs/&β;1/&γ;2 8F0J-CT-Pramlintide analogue san45-Gs/&β;1/&γ;2 6NIY-CT-Adrenomedullin-Gs/&β;1/&γ;2
19.35Single6B3JExendin-P56B3J-GLP-1-Exendin-P5-Gs/&β;1/&γ;2
19.35Single6LMLGlucagon6LML-Glucagon-Glucagon
19.35Single6UUSAdrenomedullin6UUS-CT Like (AM2)-Adrenomedullin-Gs/&β;1/&γ;2; RAMP3
19.35Single6WZGSecretin6WZG-Secretin-Secretin-Gs/&β;1/&γ;2
19.35Single7KI1Taspoglutide7KI1-GLP-1-Taspoglutide-Gs/&β;1/&γ;2
19.35Single8HAFPTHrP(1-36)8HAF-PTH1-PTHrP(1-36)-chim(NtGi1-Gs)/&β;1/&γ;2
19.35Consensuscrf1_onOrthosteric Ligand6P9X-CRF1-Corticoliberin-Gs/&β;1/&γ;2
19.35Consensuscrf_onOrthosteric Ligandcrf2_on crf1_on
19.23Single7F1QMIP-1a7F1Q-CCR5-MIP-1a-Gi1/&β;1/&γ;2
19.23Single7VBINon-Acylated Tirzepatide7VBI-GLP-1-Non-Acylated Tirzepatide-Gs/&β;1/&γ;2
19.23Single7WJ5Somatostatin-147WJ5-SST2-Somatostatin-14-Gi1/&β;1/&γ;2
19.05Single2RH1(S)-Carazolol2RH1-β2-(S)-Carazolol
19.05Single2YCW(S)-Carazolol2YCW-β1-(S)-Carazolol
19.05Single5D6L(S)-Carazolol5D6L-β2-(S)-Carazolol
19.05Single5WQCEMPA5WQC-OX2-EMPA
19.05Single6D26Fevipiprant6D26-DP2-Fevipiprant
19.05Single6GPXMK08126GPX-CCR2-MK0812
19.05Single6LFMInterleukin-86LFM-CXCR2-Interleukin-8-Gi1/&β;1/&γ;2
19.05Single6ME82-Phenylmelatonin6ME8-MT2-2-Phenylmelatonin
19.05Single6N4BMDMB-Fubinaca6N4B-CB1-MDMB-Fubinaca-Gi1/&β;1/&γ;2
19.05Single6Z4SSR486926Z4S-NTS1-SR48692
19.05Single6Z8NSRI-98296Z8N-NTS1-SRI-9829
19.05Single7SINNPS-21437SIN-CaS-NPS-2143
19.05Single7SINNPS-21437SIN-CaS-NPS-2143
19.05Single7VFXfMLF7VFX-FPR1-ALX-fMLF-Gi1/&β;1/&γ;2
19.05Single7VV0PAMP-127VV0-MRGPRX2-PAMP-12
19.05Single7WIGL-054,2647WIG-SST2-L-054,264-Gi1/&β;1/&γ;2
19.05Single7Y26Octreotide7Y26-SST2-Octreotide-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
19.05Single7Y27Somatostatin-147Y27-SST2-Somatostatin-14-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
19.05Single8C9WEtrumadenant8C9W-A2A-Etrumadenant
19.05Single8JPCNeurotensin 8-138JPC-NTS1-Neurotensin 8-13-PubChem 118610427; GDP; Mg-Gq; GRK2
19.05Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
19.05Consensusalpha2a_onOrthosteric Ligand7EJ0-α2a-L-Norepinephrine-Go/&β;1/&γ;2 7EJK-α2a-Oxymetazoline-Go/&β;1/&γ;2 7W7E-α2a-W58-Go/&β;1/&γ;2 7W6P-α2a-W96-Go/&β;1/&γ;2 7EJ8-α2a-Brimonidine-Go/&β;1/&γ;2 7EJA-α2a-Dexmedetomidine-Go/&β;1/&γ;2
19.05Consensusamine_offOrthosteric Ligandadrenergic_off histamine_off muscarinic_off 5ht_off dopamine_off
19.05Consensusbeta2_offOrthosteric Ligand6PS2-β2-(S)-Alprenolol 6PS3-β2-(S)-Carvedilol 6PS5-β2-(S)-Propranolol 6PS6-β2-Timolol 2RH1-β2-(S)-Carazolol 6PS4-β2-ICI 118-551 3NY9-β2-PubChem 913103
19.05Consensusbeta_offOrthosteric Ligandbeta1_off beta2_off
19.05Consensusd2_onOrthosteric Ligand7JVR-D2-Bromoergocryptine-Gi1/&β;1/&γ;2 8IRS-D2-Rotigotine-Gi1/&β;1/&γ;2
19.05Consensusgo_amineOrthosteric Ligandgo_adrenergic go_muscarinic go_5ht
19.05Consensusgs_sstOrthosteric Ligand7Y27-SST2-Somatostatin-14-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
19.05Consensusta1_onOrthosteric Ligand8W87-TA1-METH-chim(NtGi1L-Gs)/&β;1/&γ;2 8W89-TA1-PEA-chim(NtGi1L-Gs)/&β;1/&γ;2 8JLP-TA1-Ralmitaront-Gs/&β;1/&γ;2 8W8A-TA1-RO5256390-chim(NtGi1L-Gs)/&β;1/&γ;2 8W88-TA1-SEP-363856-Gs/&β;1/&γ;2 8JLN-TA1-T1AM-Gs/&β;1/&γ;2 8JLO-TA1-Ulotaront-Gs/&β;1/&γ;2 8JLR-TA1-A77636-chim(NtGi1-Gs)/&β;1/&γ;2 8JSO-TA1-AMPH-chim(NtGi1-Gs)/&β;1/&γ;2 8JLQ-TA1-Fenoldopam-Gs/&β;1/&γ;2 8WCA-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/&β;1/&γ;2
18.92Consensusgs_pthOrthosteric Ligand8FLQ-PTH1-PTH-Gs/&β;1/&γ;2 7Y35-PTH1-Abaloparatide-Gs/&β;1/&γ;2 7Y36-PTH1-Teriparatide-Gs/&β;1/&γ;2 7F16-PTH2-TIP39-Gs/&β;1/&γ;2 7VVM-PTH1-PTH-Gs/&β;1/&γ;2 8FLU-PTH1-Long-acting PTH-Gs/&β;1/&γ;2 6NBF-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2
18.75Single6XBM25(S)-Epoxycholesterol6XBM-SMO-25(S)-Epoxycholesterol-Gi1/&β;1/&γ;2
18.75Single7DUQGLP-17DUQ-GLP-1-GLP-1-PubChem 156022738-Gs/&β;1/&γ;2
18.75Single8HVINOX-6-78HVI-GPR132-NOX-6-7-Gi1/&β;1/&γ;2
18.75Consensusgs_crfOrthosteric Ligand6P9X-CRF1-Corticoliberin-Gs/&β;1/&γ;2
18.52Single7F4DAlpha-MSH7F4D-MC1-Alpha-MSH-chim(NtGi1-Gs)/&β;1/&γ;2
18.52Single7VVNPTH7VVN-PTH1-PTH-Gs/&β;1/&γ;2
18.52Single7XAUOctreotide7XAU-SST2-Octreotide-Gi1/&β;1/&γ;2
18.52Single7XNACYN1548067XNA-SST2-CYN154806
18.52Single8XZHMM078XZH-Apelin-MM07-Gi1/&β;1/&γ;2
18.52Consensusmc3_onOrthosteric Ligand8IOC-MC3-Gamma-MSH-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
18.52Consensussst2_offOrthosteric Ligand7XNA-SST2-CYN154806
18.42Consensusglu_onOrthosteric Ligand6LMK-Glucagon-Glucagon-Gs/&β;1/&γ;2 6WPW-Glucagon-Glucagon derivative ZP3780-Gs/&β;1/&γ;2 8JIT-Glucagon-MEDI0382-Gs/&β;1/&γ;2 8JIQ-Glucagon-Peptide-15-Gs/&β;1/&γ;2 7V35-Glucagon-Peptide-20-Gs/&β;1/&γ;2 8JIU-Glucagon-SAR425899-Gs/&β;1/&γ;2 6WHC-Glucagon-Glu16 analog of GCG-Gs/&β;1/&γ;2
18.18Single5D5A(S)-Carazolol5D5A-β2-(S)-Carazolol
18.18Single5D5B(S)-Carazolol5D5B-β2-(S)-Carazolol
18.18Single5ZHPPubChem 1348285895ZHP-M3-PubChem 134828589
18.18Single5ZKBAF-DX 3845ZKB-M2-AF-DX 384
18.18Single6E59L-7607356E59-NK1-L-760735
18.18Single6J20Aprepitant6J20-NK1-Aprepitant
18.18Single6KO5PubChem 574000026KO5-Ghrelin-PubChem 57400002
18.18Single6TQ7SB-3348676TQ7-OX1-SB-334867
18.18Single6WPWGlucagon derivative ZP37806WPW-Glucagon-Glucagon derivative ZP3780-Gs/&β;1/&γ;2
18.18Single6Z4QSR142948A6Z4Q-NTS1-SR142948A
18.18Single7B6WCyclazosin7B6W-α1b-Cyclazosin
18.18Single7E2ZAripiprazole7E2Z-5-HT1A-Aripiprazole-Gi1/&β;1/&γ;2
18.18Single7VBHPeptide-207VBH-GLP-1-Peptide-20-Gs/&β;1/&γ;2
18.18Single7VGY2-Iodomelatonin7VGY-MT1-2-Iodomelatonin-Gi1/&β;1/&γ;2
18.18Single7W41PD1762527W41-BB2-PD176252
18.18Single7W6PW967W6P-α2a-W96-Go/&β;1/&γ;2
18.18Single7W7EW587W7E-α2a-W58-Go/&β;1/&γ;2
18.18Single7XJLSpexin7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
18.18Single7XWONeurokinin-A7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
18.18Single8FLULong-acting PTH8FLU-PTH1-Long-acting PTH-Gs/&β;1/&γ;2
18.18Single8IYWGSK2560738IYW-HCA2-GSK256073-Go/&β;1/&γ;2
18.18Single8JD0J9R8JD0-mGlu2; mGlu3-Glutamate-J9R
18.18Single8JLPRalmitaront8JLP-TA1-Ralmitaront-Gs/&β;1/&γ;2
18.18Single8JT6(R)-IHCH-71798JT6-5-HT1A-(R)-IHCH-7179-Gi1/&β;1/&γ;2
18.18Single8JXWVUF68848JXW-H4-VUF6884-Gi1/&β;1/&γ;2
18.18Single8JXXClobenpropit8JXX-H4-Clobenpropit-Gi1/&β;1/&γ;2
18.18Consensus5ht_offOrthosteric Ligand5ht2_off 5ht5_off 5ht1_off
18.18Consensusalpha1b_offOrthosteric Ligand7B6W-α1b-Cyclazosin
18.18Consensusarrestin2Orthosteric Ligand6TKO-β1-Arformoterol-Arrestin2 6PWC-NTS1-Neurotensin-Arrestin2 7R0C-V2-Acyclovir triphosphate-Arrestin2
18.18Consensusbb2_offOrthosteric Ligand7W41-BB2-PD176252
18.18Consensusbeta1_offOrthosteric Ligand2VT4-β1-Cyanopindolol 2YCZ-β1-Iodocyanopindolol
18.18Consensusbombesin_offOrthosteric Ligandbb2_off
18.18Consensuscck_onOrthosteric Ligandccka_on cckb_on
18.18Consensuschemerin_onOrthosteric Ligandcml1_on
18.18Consensuscml1_onOrthosteric Ligand8SG1-CML1-Chemerin-9-Gi1/&β;1/&γ;2
18.18Consensusgi_amineOrthosteric Ligandgi_5ht gi_adrenergic gi_dopamine gi_muscarinic gi_histamine
18.18Consensusglp_onOrthosteric Ligandglp1_on glp2_on
18.18Consensusgo_adrenergicOrthosteric Ligand7EJ0-α2a-L-Norepinephrine-Go/&β;1/&γ;2 7EJK-α2a-Oxymetazoline-Go/&β;1/&γ;2 7W7E-α2a-W58-Go/&β;1/&γ;2 7W6P-α2a-W96-Go/&β;1/&γ;2 6K41-α2b-Dexmedetomidine-Go/&β;1/&γ;2 7EJ8-α2a-Brimonidine-Go/&β;1/&γ;2 7EJA-α2a-Dexmedetomidine-Go/&β;1/&γ;2
18.18Consensush1_offOrthosteric Ligand3RZE-H1-Cidoxepin 8X5Y-H1-Astemizole 8X63-H1-Mepyramine 8X64-H1-Desloratadine
18.18Consensushistamine_offOrthosteric Ligandh1_off
18.18Consensusnk1_offOrthosteric Ligand6J20-NK1-Aprepitant 6HLL-NK1-CP99994 6E59-NK1-L-760735
18.18Consensusnpy_offOrthosteric Ligandnpy2_off npy1_off
17.86Single6M1IPACAP6M1I-PAC1-PACAP-Gs/&β;1/&γ;2
17.86Single6WIVPubChem 52923113; PubChem 529246456WIV-GABAB1, GABAB2-PubChem 52923113; PubChem 52924645
17.86Single8HA0PTH8HA0-PTH1-PTH-chim(NtGi1-Gs)/&β;1/&γ;2
17.86Single8HNKCXCL118HNK-CXCR3-CXCL11-Gi1/&β;1/&γ;2
17.86Consensusnmur2_onOrthosteric Ligand7W57-NMUR2-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
17.65Single2J4Y11-cis-Retinal2J4Y-Rhodopsin-11-cis-Retinal
17.65Single3OE6IT1t3OE6-CXCR4-IT1t
17.65Single3OE8IT1t3OE8-CXCR4-IT1t
17.65Single3UZAGTPL92363UZA-A2A-GTPL9236
17.65Single4XNWMRS25004XNW-P2Y1-MRS2500
17.65Single5WKTOctyl Beta-D-Glucopyranoside5WKT-Rhodopsin-Octyl Beta-D-Glucopyranoside-Gt(CT)
17.65Single6FK9PubChem 1324730366FK9-Rhodopsin-PubChem 132473036
17.65Single6ME5Agomelatine6ME5-MT1-Agomelatine
17.65Single6ME9Ramelteon6ME9-MT2-Ramelteon
17.65Single7S8O(R)-Zinc-35737S8O-MRGPRX2-(R)-Zinc-3573-Gi1/&β;1/&γ;2
17.65Single7V35Peptide-207V35-Glucagon-Peptide-20-Gs/&β;1/&γ;2
17.65Single8F76-8F76-OR51E2-Gs/&β;1/&γ;2
17.65Single8GGREpinephrine8GGR-β2-Epinephrine
17.65Single8GGZEpinephrine8GGZ-β2-Epinephrine
17.65Single8J6QBeta-hydroxybutyrate8J6Q-HCA2-Beta-hydroxybutyrate-Compound 9n-Gi1/&β;1/&γ;2
17.65Single8JIPMEDI03828JIP-GLP-1-MEDI0382-chim(NtGi1-Gs)/&β;1/&γ;2
17.65Single8JRVGlucagon8JRV-Glucagon-Glucagon-Arrestin2
17.65Consensusp2y1_offOrthosteric Ligand4XNW-P2Y1-MRS2500
17.65Consensuspth1_onOrthosteric Ligand8FLQ-PTH1-PTH-Gs/&β;1/&γ;2 8FLR-PTH1-PTHrP(1-36)-Gs/&β;1/&γ;2 7Y36-PTH1-Teriparatide-Gs/&β;1/&γ;2 7Y35-PTH1-Abaloparatide-Gs/&β;1/&γ;2 8FLU-PTH1-Long-acting PTH-Gs/&β;1/&γ;2 6NBF-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2 7VVM-PTH1-PTH-Gs/&β;1/&γ;2
17.65Consensussmo_off_alloOrthosteric Ligand6D32-SMO-Cyclopamine-Cyclopamine
17.39Single3D4STimolol Maleate3D4S-β2-Timolol Maleate
17.39Single3VW7Vorapaxar; Na3VW7-PAR1-Vorapaxar; Na
17.39Single4N4WSANT-14N4W-SMO-SANT-1
17.39Single6A93Risperidone6A93-5-HT2A-Risperidone
17.39Single6ME62-Phenylmelatonin6ME6-MT2-2-Phenylmelatonin
17.39Single6W2YPubChem 237279706W2Y-GABAB1; GABAB1-PubChem 5311042-PubChem 23727970
17.39Single6W2YPubChem 237279706W2Y-GABAB1; GABAB1-PubChem 5311042-PubChem 23727970
17.39Single6XBLCholesterol6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
17.39Single6XOXOrforglipron6XOX-GLP-1-Orforglipron-chim(NtGi1-Gs)/&β;1/&γ;2
17.39Single6ZG4HTL00099366ZG4-M1-HTL0009936
17.39Single7JNIOlodanrigan7JNI-AT2-Olodanrigan
17.39Single7WCMMBX-29827WCM-GPR119-MBX-2982-Gs/&β;1/&γ;2
17.39Single7XJKGalanin7XJK-GAL2-Galanin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
17.39Single7XW6ML1097XW6-TSH-M22 Fab-ML109-Gs/&β;1/&γ;2
17.39Single7XW9TRH7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
17.39Single8H0QGastrin Releasing Peptide8H0Q-BB2-Gastrin Releasing Peptide-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
17.39Consensusadgrg_onOrthosteric Ligandadgrg2_on adgrg3_on
17.39Consensusat2_offOrthosteric Ligand7JNI-AT2-Olodanrigan
17.39Consensusclass-b2_onOrthosteric Ligandadgrg_on
17.39Consensusgi_class-fOther Ligandgi_frizzled
17.39Consensusgi_frizzledOther Ligand6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
17.39Consensusgpr119_onOrthosteric Ligand7XZ6-GPR119-APD668-Gs/&β;1/&γ;2 7WCN-GPR119-AR231453-Gs/&β;1/&γ;2 7XZ5-GPR119-Lysophosphatidylcholine-Gs/&β;1/&γ;2 7WCM-GPR119-MBX-2982-Gs/&β;1/&γ;2
17.39Consensusgs_trhOrthosteric Ligand7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
17.39Consensusnts1_offOrthosteric Ligand6Z4Q-NTS1-SR142948A 6Z4S-NTS1-SR48692
17.39Consensusnts_offOrthosteric Ligandnts1_off
17.39Consensustrh_onOrthosteric Ligand7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
17.24Single6UUNAdrenomedullin6UUN-CT Like (AM1)-Adrenomedullin-Gs/&β;1/&γ;2; RAMP2
17.24Single7LLYOxyntomodulin7LLY-GLP-1-Oxyntomodulin-Gs/&β;1/&γ;2
17.24Single7QBIAlpha-factor mating pheromone7QBI-STE2-Alpha-factor mating pheromone
17.24Single7TRYUrocortin7TRY-CRF2-Urocortin-chim(NtGi1-G11)/&β;1/&γ;2
17.24Single7V9MSomatoliberin7V9M-GHRH (SV1)-Somatoliberin-Gs/&β;1/&γ;2
17.24Single7WBJPACAP277WBJ-VPAC1-PACAP27-Gs/&β;1/&γ;2
17.24Single8KH5Lysophosphatidylserine8KH5-GPR174-Lysophosphatidylserine-Gs/&β;1/&γ;2
17.24Consensusbk1_onOrthosteric Ligand7EIB-BK1-Des-Arg10-Kallidin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
17.24Consensusbombesin_onOrthosteric Ligandbb2_on bb1_on
17.24Consensuscrf2_onOrthosteric Ligand7TS0-CRF2-Urocortin-chim(NtGi1L-Go)/&β;1/&γ;2
17.14Single7Y36Teriparatide7Y36-PTH1-Teriparatide-Gs/&β;1/&γ;2
17.14Single8FLQPTH8FLQ-PTH1-PTH-Gs/&β;1/&γ;2
17.14Consensusgs_glucagonOrthosteric Ligand6X18-GLP-1-GLP-1-Gs/&β;1/&γ;2 6B3J-GLP-1-Exendin-P5-Gs/&β;1/&γ;2 6WZG-Secretin-Secretin-Gs/&β;1/&γ;2 6X1A-GLP-1-Danuglipron-Gs/&β;1/&γ;2 7CZ5-GHRH-Somatoliberin-Gs/&β;1/&γ;2 7D68-GLP-2-GLP-2-Gs/&β;1/&γ;2 7DTY-GIP-GIP-Gs/&β;1/&γ;2 7FIM-GLP-1-Tirzepatide-Gs/&β;1/&γ;2 7FIN-GIP-Peptide-20; GGL-Gs/&β;1/&γ;2 7FIY-GIP-Tirzepatide-Gs/&β;1/&γ;2 7KI0-GLP-1-Semaglutide-Gs/&β;1/&γ;2 7RTB-GLP-1-Peptide-19-Gs/&β;1/&γ;2 7S1M-GLP-1-Ex4-D-Ala-Gs/&β;1/&γ;2 7VAB-GIP-Non-Acylated Tirzepatide-chim(NtGi1-Gs)/&β;1/&γ;2 8JIU-Glucagon-SAR425899-Gs/&β;1/&γ;2
17.14Consensusgs_vip-pacapOrthosteric Ligand8E3Y-VPAC1-PACAP27-Gs/&β;1/&γ;2 7VQX-VPAC1-PACAP27-Gs/&β;1/&γ;2 8E3Z-VPAC1-VIP-Gs/&β;1/&γ;2 6M1I-PAC1-PACAP-Gs/&β;1/&γ;2 6VN7-VPAC1-PACAP-Gs/&β;1/&γ;2
16.67Single3OE9IT1t3OE9-CXCR4-IT1t
16.67Single3PBLEticlopride3PBL-D3-Eticlopride
16.67Single5L7IVismodegib5L7I-SMO-Vismodegib
16.67Single5OLVLUAA410635OLV-A2A-LUAA41063-Na
16.67Single5UNGPubChem 157800525UNG-AT2-PubChem 15780052
16.67Single6BQHRitanserin6BQH-5-HT2C-Ritanserin
16.67Single6E3YCalcitonin gene-related peptide-16E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/&β;1/&γ;2; RAMP1
16.67Single6FK6PubChem 1324730336FK6-Rhodopsin-PubChem 132473033
16.67Single6I9K9-cis-Retinal6I9K-Rhodopsin-9-cis-Retinal
16.67Single6M1HMaxadilan6M1H-PAC1-Maxadilan-Gs/&β;1/&γ;2
16.67Single6NBFLong-acting PTH analog6NBF-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2
16.67Single6PGSGeraniol6PGS-Rhodopsin-Geraniol-Gt(CT)
16.67Single7D3SSecretin7D3S-Secretin-Secretin-Gs/&β;1/&γ;2
16.67Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
16.67Single7EJKOxymetazoline7EJK-α2a-Oxymetazoline-Go/&β;1/&γ;2
16.67Single7EZHCholecystokinin-87EZH-CCKA-Cholecystokinin-8-Gi1/&β;1/&γ;2
16.67Single7EZMCholecystokinin-87EZM-CCKA-Cholecystokinin-8-chim(NtGsL-Gq)/&β;1/&γ;2
16.67Single7F8VGastrin-177F8V-CCKB-Gastrin-17-Gi2/&β;1/&γ;2
16.67Single7KI0Semaglutide7KI0-GLP-1-Semaglutide-Gs/&β;1/&γ;2
16.67Single7MBYCholecystokinin-87MBY-CCKA-Cholecystokinin-8-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
16.67Single7QBIAlpha-factor mating pheromone7QBI-STE2-Alpha-factor mating pheromone
16.67Single7QVMOxytocin7QVM-OT-Oxytocin-chim(NtGi1-Go-CtGq)/&β;1/&γ;2
16.67Single7S8N(R)-Zinc-35737S8N-MRGPRX2-(R)-Zinc-3573-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
16.67Single7SK7CCX6627SK7-ACKR3-CXCL12-CCX662
16.67Single7SK8CCX6627SK8-ACKR3-CXCL12-CCX662
16.67Single7SRQLSD7SRQ-5-HT2B-LSD
16.67Single7TRPLY20332987TRP-M4-Iperoxo-LY2033298-Gi1/&β;1/&γ;2
16.67Single7U2KC6-guano7U2K-μ-C6-guano-Gi1/&β;1/&γ;2
16.67Single7W57Neuromedin-S7W57-NMUR2-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
16.67Single7XT9Serotonin7XT9-5-HT4-Serotonin-Gs/&β;1/&γ;2
16.67Single7XTBSerotonin7XTB-5-HT6-Serotonin-Gs/&β;1/&γ;2
16.67Single7XV3Lysophosphatidylserine7XV3-GPR174-Lysophosphatidylserine-chim(NtGi1-Gs)/&β;1/&γ;2
16.67Single8A2PLUAA470708A2P-A2A-LUAA47070-Na
16.67Single8FLRPTHrP(1-36)8FLR-PTH1-PTHrP(1-36)-Gs/&β;1/&γ;2
16.67Single8GEIEpinephrine8GEI-β2-Epinephrine-Gs/&β;1/&γ;2
16.67Single8GGSEpinephrine8GGS-β2-Epinephrine
16.67Single8GGYEpinephrine8GGY-β2-Epinephrine
16.67Single8HAOPTH8HAO-PTH1-PTH-chim(NtGi1-Gs)/&β;1/&γ;2
16.67Single8HN1Toxin AdTx18HN1-Alpha1A-Toxin AdTx1
16.67Single8IHIAcifran8IHI-HCA2-Acifran-Gi1/&β;1/&γ;2
16.67Single8IJANiacin8IJA-HCA2-Niacin-Gi1/&β;1/&γ;2
16.67Single8IY9Niacin8IY9-HCA2-Niacin-Go/&β;1/&γ;2
16.67Single8JD3HZR; PEF8JD3-mGlu2; mGlu3-Glutamate-HZR; PEF-Gi1/&β;1/&γ;2
16.67Single8JIUSAR4258998JIU-Glucagon-SAR425899-Gs/&β;1/&γ;2
16.67Single8JLOUlotaront8JLO-TA1-Ulotaront-Gs/&β;1/&γ;2
16.67Single8JSOAMPH8JSO-TA1-AMPH-chim(NtGi1-Gs)/&β;1/&γ;2
16.67Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
16.67Single8U4RREGN7663-Fab8U4R-CXCR4-REGN7663-Fab-Cholesterol
16.67Single8UNVEpinephrine8UNV-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
16.67Consensus5ht2c_offOrthosteric Ligand6BQH-5-HT2C-Ritanserin
16.67Consensusclass-d_onOrthosteric Ligandste2_on
16.67Consensusd3_offOrthosteric Ligand3PBL-D3-Eticlopride
16.67Consensusgal2_onOrthosteric Ligand7WQ4-GAL2-Galanin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
16.67Consensusglp1_on_alloOrthosteric Ligand6VCB-GLP-1-GLP-1-LSN3160440-Gs/&β;1/&γ;2
16.67Consensusgo_chemokineOrthosteric Ligand6WWZ-CCR6-CCL20-Go/&β;1/&γ;2
16.67Consensusgo_proteinOrthosteric Ligandgo_chemokine
16.67Consensusgs_galaninOrthosteric Ligand7WQ4-GAL2-Galanin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
16.67Consensusgs_lipidOrthosteric Ligandgs_ffa gs_prostanoid
16.67Consensusmt1_onOrthosteric Ligand7VGY-MT1-2-Iodomelatonin-Gi1/&β;1/&γ;2 7DB6-MT1-Ramelteon-Gi1/&β;1/&γ;2
16.67Consensusnk2_onOrthosteric Ligand7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
16.67Consensusot_onOrthosteric Ligand7QVM-OT-Oxytocin-chim(NtGi1-Go-CtGq)/&β;1/&γ;2
16.13Single6P9XCorticoliberin6P9X-CRF1-Corticoliberin-Gs/&β;1/&γ;2
16.13Single7AD3Alpha-factor mating pheromone7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
16.13Single7EIBDes-Arg10-Kallidin7EIB-BK1-Des-Arg10-Kallidin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
16.13Single7QBCAlpha-factor mating pheromone7QBC-STE2-Alpha-factor mating pheromone
16.13Single7VQXPACAP277VQX-VPAC1-PACAP27-Gs/&β;1/&γ;2
16.13Single7VVJPTHrP(1-36)7VVJ-PTH1-PTHrP(1-36)-Gs/&β;1/&γ;2
16.13Consensusgi_class-dOrthosteric Ligandgi_ste
16.13Consensusgi_steOrthosteric Ligand7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
16.13Consensusgs_cgrpOrthosteric Ligand6E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/&β;1/&γ;2; RAMP1 6UUN-CT Like (AM1)-Adrenomedullin-Gs/&β;1/&γ;2; RAMP2
16.00Single6KNMJN241-96KNM-Apelin-JN241-9
16.00Single7XN9L-054,5227XN9-SST2-L-054,522
16.00Consensusfpr1-alx_onOrthosteric Ligand7VFX-FPR1-ALX-fMLF-Gi1/&β;1/&γ;2 7T6T-FPR1-ALX-fMLFII-Gi1/&β;1/&γ;2
16.00Consensusgs_adgrOrthosteric Ligand7XKD-ADGRG2-Betahydroxyandrosterone-Gs/&β;1/&γ;2 7WUI-ADGRG2-IP15-chim(NtGi1-Gs)/&β;1/&γ;2
16.00Consensusgs_bombesinOrthosteric Ligand8H0Q-BB2-Gastrin Releasing Peptide-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8H0P-BB1-NMB30-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
16.00Consensusgs_class-b2Orthosteric Ligandgs_adgr
16.00Consensusprotein_onOrthosteric Ligandccr_on chemokine_on gphr_on chemerin_on
16.00Consensusste2_offOrthosteric Ligand7QA8-STE2-Peptide
15.79Single1F8811-cis-Retinal1F88-Rhodopsin-11-cis-Retinal
15.79Single1GZM11-cis-Retinal1GZM-Rhodopsin-11-cis-Retinal
15.79Single3C9L11-cis-Retinal3C9L-Rhodopsin-11-cis-Retinal
15.79Single3ODUIT1t3ODU-CXCR4-IT1t
15.79Single4S0VSuvorexant4S0V-OX2-Suvorexant
15.79Single5U09Taranabant5U09-CB1-Taranabant
15.79Single5ZKQABT-4915ZKQ-PAF-ABT-491
15.79Single6AKYMaraviroc6AKY-CCR5-Maraviroc
15.79Single6D9HAdenosine6D9H-A1-Adenosine-Gi2/&β;1/&γ;2
15.79Single6LFOInterleukin-86LFO-CXCR2-Interleukin-8-Gi1/&β;1/&γ;2
15.79Single6ME2Ramelteon6ME2-MT1-Ramelteon
15.79Single6PWCNeurotensin6PWC-NTS1-Neurotensin-Arrestin2
15.79Single6RNKNF-56-EJ406RNK-Succinate-NF-56-EJ40
15.79Single6TPJSuvorexant6TPJ-OX2-Suvorexant
15.79Single6WWZCCL206WWZ-CCR6-CCL20-Go/&β;1/&γ;2
15.79Single7BR3Elagolix7BR3-GnRH1-Elagolix
15.79Single7DHRIsoprenaline7DHR-β2-Isoprenaline-Gs/&β;1/&γ;2
15.79Single7EJ0L-Norepinephrine7EJ0-α2a-L-Norepinephrine-Go/&β;1/&γ;2
15.79Single7F24Dopamine7F24-D1-Dopamine-GDP-Gs/&β;1/&γ;2
15.79Single7F8ULintitript7F8U-CCKA-Lintitript
15.79Single7F8YDevazepide7F8Y-CCKA-Devazepide
15.79Single7LCJDanuglipron7LCJ-GLP-1-Danuglipron
15.79Single7M3ECa; Ca; Tryptophan; NPS-2143; PO47M3E-CaS-Ca; Ca; Tryptophan; NPS-2143; PO4
15.79Single7M3ECa; Ca; Tryptophan; NPS-2143; PO47M3E-CaS-Ca; Ca; Tryptophan; NPS-2143; PO4
15.79Single7T6SPubChem 247763417T6S-FPR2-ALX-PubChem 24776341-Gi1/&β;1/&γ;2
15.79Single7W0MPubChem 1227019087W0M-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
15.79Single7W0OElabela7W0O-Apelin-Elabela-Gi1/&β;1/&γ;2
15.79Single7X2FDopamine7X2F-D1-Dopamine-Mevidalen-Gs/&β;1/&γ;2
15.79Single7X5H5-CT7X5H-5-HT5A-5-CT-Gi1/&β;1/&γ;2
15.79Single7XT8Serotonin7XT8-5-HT4-Serotonin-Gs/&β;1/&γ;2
15.79Single7YMHNorepinephrine7YMH-Alpha1A-Norepinephrine-chim(Gs-CtGq)/&β;1/&γ;2
15.79Single8FN0Neurotensin/neuromedin N8FN0-NTS1-Neurotensin/neuromedin N-PubChem 118610427-chim(NtGi1-Go)/&β;1/&γ;2
15.79Single8GECEpinephrine8GEC-β2-Epinephrine-Gs/&β;1/&γ;2
15.79Single8GEDEpinephrine8GED-β2-Epinephrine-Gs/&β;1/&γ;2
15.79Single8GEFEpinephrine8GEF-β2-Epinephrine-Gs/&β;1/&γ;2
15.79Single8GG7Epinephrine8GG7-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
15.79Single8GG9Epinephrine8GG9-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
15.79Single8GGAEpinephrine8GGA-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
15.79Single8GGVEpinephrine8GGV-β2-Epinephrine
15.79Single8GGWEpinephrine8GGW-β2-Epinephrine
15.79Single8GGXEpinephrine8GGX-β2-Epinephrine
15.79Single8GH0Epinephrine8GH0-β2-Epinephrine
15.79Single8IHKAcifran8IHK-HCA3-Acifran
15.79Single8IJBAcipimox8IJB-HCA2-Acipimox-Gi1/&β;1/&γ;2
15.79Single8J6LNiacin8J6L-HCA2-Niacin-Gi1/&β;1/&γ;2
15.79Single8UNLEpinephrine8UNL-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
15.79Single8UNOEpinephrine8UNO-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
15.79Single8UNTEpinephrine8UNT-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
15.79Single8UNUEpinephrine8UNU-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
15.79Single8UNWEpinephrine8UNW-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
15.79Single8UO1Epinephrine8UO1-β2-Epinephrine-GTP; Mg-Gs/&β;1/&γ;2
15.79Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
15.79Consensus5ht_onOrthosteric Ligand5ht1_on 5ht2_on 5ht4_on 5ht5_on 5ht6_on 5ht7_on
15.79Consensusalpha1_onOrthosteric Ligandalpha1a_on
15.79Consensusalpha1a_onOrthosteric Ligand7YMH-Alpha1A-Norepinephrine-chim(Gs-CtGq)/&β;1/&γ;2 7YM8-Alpha1A-Oxymetazoline-chim(Gs-CtGq)/&β;1/&γ;2 8THK-Alpha1A-A61603-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8THL-Alpha1A-Epinephrine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
15.79Consensusccr6_onOrthosteric Ligand6WWZ-CCR6-CCL20-Go/&β;1/&γ;2
15.79Consensusglucagon_onOrthosteric Ligandgip_on glu_on secretin_on ghrh_on glp_on
15.79Consensusgnrh1_offOrthosteric Ligand7BR3-GnRH1-Elagolix
15.79Consensusgs_5htOrthosteric Ligand7XT8-5-HT4-Serotonin-Gs/&β;1/&γ;2 7XTB-5-HT6-Serotonin-Gs/&β;1/&γ;2 8JLZ-5-HT6-ST1936-Gs/&β;1/&γ;2 7XTC-5-HT7-5-CT-Gs/&β;1/&γ;2 6WHA-5-HT2A-DB13948-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 7RAN-5-HT2A-PubChem 164575847-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8DPF-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8DPG-5-HT2C-Psilocin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
15.79Consensusm2_on_alloOther Ligand7T94-M2-Acetylcholine-PubChem 57664406-chim(NtGi1-Go)/&β;1/&γ;2 6OIK-M2-Iperoxo-LY2119620-chim(NtGi1-Go)/&β;1/&γ;2
15.79Consensusmelatonin_onOrthosteric Ligandmt1_on mt2_on
15.62Single6NBHLong-acting PTH analog6NBH-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2
15.62Single6PB1Urocortin6PB1-CRF2-Urocortin-chim(NtGi1-Gs)/&β;1/&γ;2
15.62Single7D68GLP-27D68-GLP-2-GLP-2-Gs/&β;1/&γ;2
15.62Single7QBCAlpha-factor mating pheromone7QBC-STE2-Alpha-factor mating pheromone
15.62Single7VVKPTH7VVK-PTH1-PTH-Gs/&β;1/&γ;2
15.62Single7VVLPTH7VVL-PTH1-PTH-Gs/&β;1/&γ;2
15.62Consensusglp1_onOrthosteric Ligand6X18-GLP-1-GLP-1-Gs/&β;1/&γ;2 6X19-GLP-1-CHU-128-Gs/&β;1/&γ;2 6X1A-GLP-1-Danuglipron-Gs/&β;1/&γ;2 7S1M-GLP-1-Ex4-D-Ala-Gs/&β;1/&γ;2 7LLL-GLP-1-Exendin-4-Gs/&β;1/&γ;2 6B3J-GLP-1-Exendin-P5-Gs/&β;1/&γ;2 8JIP-GLP-1-MEDI0382-chim(NtGi1-Gs)/&β;1/&γ;2 7VBI-GLP-1-Non-Acylated Tirzepatide-Gs/&β;1/&γ;2 6XOX-GLP-1-Orforglipron-chim(NtGi1-Gs)/&β;1/&γ;2 8JIS-GLP-1-Peptide-15-chim(NtGi1-Gs)/&β;1/&γ;2 7RTB-GLP-1-Peptide-19-Gs/&β;1/&γ;2 7VBH-GLP-1-Peptide-20-Gs/&β;1/&γ;2 7C2E-GLP-1-PubChem 149050799-Gs/&β;1/&γ;2 8JIR-GLP-1-SAR425899-chim(NtGi1-Gs)/&β;1/&γ;2 7KI0-GLP-1-Semaglutide-Gs/&β;1/&γ;2 7KI1-GLP-1-Taspoglutide-Gs/&β;1/&γ;2 7FIM-GLP-1-Tirzepatide-Gs/&β;1/&γ;2
15.62Consensussecretin_onOrthosteric Ligand6WZG-Secretin-Secretin-Gs/&β;1/&γ;2
15.62Consensusvpac2_onOrthosteric Ligand7VQX-VPAC1-PACAP27-Gs/&β;1/&γ;2
15.38Single5UNFPubChem 157800525UNF-AT2-PubChem 15780052
15.38Single6X19CHU-1286X19-GLP-1-CHU-128-Gs/&β;1/&γ;2
15.38Single7RTBPeptide-197RTB-GLP-1-Peptide-19-Gs/&β;1/&γ;2
15.38Single7VLACCL15(27-92)7VLA-CCR1-CCL15(27-92)-Gi1/&β;1/&γ;2
15.38Single7WICSomatostatin-147WIC-SST2-Somatostatin-14-Gi1/&β;1/&γ;2
15.38Single7WVWfMYFINILTL7WVW-FPR2-ALX-fMYFINILTL-Gi2/&β;1/&γ;2
15.38Single8JIQPeptide-158JIQ-Glucagon-Peptide-15-Gs/&β;1/&γ;2
15.38Consensusalpha1a_offOrthosteric Ligand7YMJ-Alpha1A-Tamsulosin 8HN1-Alpha1A-Toxin AdTx1
15.38Consensusclass-b1_onOrthosteric Ligandglucagon_on calcitonin_on vip-pacap_on pth_on crf_on
15.38Consensusnmur1_onOrthosteric Ligand7W56-NMUR1-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
15.38Consensussst2_onOrthosteric Ligand7XMR-SST2-Somatostatin-14-Gi1/&β;1/&γ;2 7XAU-SST2-Octreotide-Gi1/&β;1/&γ;2 7YAC-SST2-Paltusotine-Gi1/&β;1/&γ;2
15.38Consensusste2_offOrthosteric Ligand7QA8-STE2-Peptide
15.15Single7RBTTirzepatide7RBT-GIP-Tirzepatide-PubChem 163183774-chim(NtGi1-Gs)/&β;1/&γ;2
15.15Consensusgip_onOrthosteric Ligand7DTY-GIP-GIP-Gs/&β;1/&γ;2 7VAB-GIP-Non-Acylated Tirzepatide-chim(NtGi1-Gs)/&β;1/&γ;2 7FIN-GIP-Peptide-20; GGL-Gs/&β;1/&γ;2 7FIY-GIP-Tirzepatide-Gs/&β;1/&γ;2
15.15Consensusgip_on_alloOrthosteric Ligand7RBT-GIP-Tirzepatide-PubChem 163183774-chim(NtGi1-Gs)/&β;1/&γ;2
15.00Single2YDOAdenosine2YDO-A2A-Adenosine
15.00Single3OAX11-cis-Retinal3OAX-Rhodopsin-11-cis-Retinal
15.00Single6FKAPubChem 1324730376FKA-Rhodopsin-PubChem 132473037
15.00Single6K41Dexmedetomidine6K41-α2b-Dexmedetomidine-Go/&β;1/&γ;2
15.00Single6ME42-Iodomelatonin6ME4-MT1-2-Iodomelatonin
15.00Single6TPKRetosiban6TPK-OT-Retosiban
15.00Single6ZDVPubChem 9840736ZDV-A2A-PubChem 984073-Na
15.00Single6ZFZ77-LH-28-16ZFZ-M1-77-LH-28-1
15.00Single6ZG9GSK10347026ZG9-M1-GSK1034702
15.00Single6ZINSR486926ZIN-NTS1-SR48692
15.00Single7BB6Acyclovir triphosphate7BB6-V2-Acyclovir triphosphate-Gs/&β;1/&γ;2
15.00Single7CMVPD1289077CMV-D3-PD128907-Gi1/&β;1/&γ;2
15.00Single7DHISalbutamol7DHI-β2-Salbutamol-Gs/&β;1/&γ;2
15.00Single7E33BRL-544437E33-5-HT1E-BRL-54443-Gi1/&β;1/&γ;2
15.00Single7EJ8Brimonidine7EJ8-α2a-Brimonidine-Go/&β;1/&γ;2
15.00Single7EJADexmedetomidine7EJA-α2a-Dexmedetomidine-Go/&β;1/&γ;2
15.00Single7UTZPubChem 6440787UTZ-TSH-TR1402-PubChem 644078-Gs/&β;1/&γ;2
15.00Single7VUGJNJ-635330547VUG-GPR139-JNJ-63533054-Gi1/&β;1/&γ;2
15.00Single7WC9PubChem 1624213647WC9-5-HT2A-PubChem 162421364
15.00Single7WVUfMLF7WVU-FPR1-ALX-fMLF-Gi1/&β;1/&γ;2
15.00Single7XJJGalanin7XJJ-GAL1-Galanin-Go/&β;1/&γ;2
15.00Single7XOVSR1461317XOV-CCKA-SR146131-Gs/&β;1/&γ;2
15.00Single7ZBC11-cis-Retinal7ZBC-Rhodopsin-11-cis-Retinal
15.00Single7ZBE11-cis-Retinal7ZBE-Rhodopsin-11-cis-Retinal
15.00Single8FCZ11-cis-Retinal8FCZ-Rhodopsin-11-cis-Retinal
15.00Single8GE1Epinephrine8GE1-β2-Epinephrine-Gs/&β;1/&γ;2
15.00Single8GE4Epinephrine8GE4-β2-Epinephrine-Gs/&β;1/&γ;2
15.00Single8GE6Epinephrine8GE6-β2-Epinephrine-Gs/&β;1/&γ;2
15.00Single8GE7Epinephrine8GE7-β2-Epinephrine-Gs/&β;1/&γ;2
15.00Single8GE8Epinephrine8GE8-β2-Epinephrine-Gs/&β;1/&γ;2
15.00Single8GE9Epinephrine8GE9-β2-Epinephrine-Gs/&β;1/&γ;2
15.00Single8GFVEpinephrine8GFV-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
15.00Single8GG3Epinephrine8GG3-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
15.00Single8GG4Epinephrine8GG4-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
15.00Single8GG8Epinephrine8GG8-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
15.00Single8GGIEpinephrine8GGI-β2-Epinephrine
15.00Single8GGLEpinephrine8GGL-β2-Epinephrine
15.00Single8JIMMMF8JIM-HCA2-MMF-Gi1/&β;1/&γ;2
15.00Single8JLKUlotaront8JLK-TA1-Ulotaront-chim(NtGi1-Gs)/&β;1/&γ;2
15.00Single8THKA616038THK-Alpha1A-A61603-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
15.00Single8UNQEpinephrine8UNQ-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
15.00Single8UNREpinephrine8UNR-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
15.00Single8UNSEpinephrine8UNS-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
15.00Single8W88SEP-3638568W88-TA1-SEP-363856-Gs/&β;1/&γ;2
15.00Single8X7ATreprostinil8X7A-I2-Treprostinil-Gs/&β;1/&γ;2
15.00Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
15.00Consensus5ht1e_onOrthosteric Ligand7E33-5-HT1E-BRL-54443-Gi1/&β;1/&γ;2
15.00Consensusalpha2b_onOrthosteric Ligand6K41-α2b-Dexmedetomidine-Go/&β;1/&γ;2
15.00Consensusat1_offOrthosteric Ligand4YAY-AT1-ZD-7155 4ZUD-AT1-Olmesartan
15.00Consensuscb1_offOrthosteric Ligand5TGZ-CB1-AM6538 5U09-CB1-Taranabant
15.00Consensusghrelin_offOrthosteric Ligand6KO5-Ghrelin-PubChem 57400002 7F83-Ghrelin-PF-05190457
15.00Consensusgi_melatoninOrthosteric Ligand7VGY-MT1-2-Iodomelatonin-Gi1/&β;1/&γ;2 7DB6-MT1-Ramelteon-Gi1/&β;1/&γ;2 7VH0-MT2-Ramelteon-Gi1/&β;1/&γ;1
15.00Consensusgnrh_offOrthosteric Ligandgnrh1_off
15.00Consensusgo_galaninOrthosteric Ligand7XJJ-GAL1-Galanin-Go/&β;1/&γ;2
15.00Consensusnop_offOrthosteric Ligand4EA3-NOP-PubChem 10296561 5DHG-NOP-PubChem 25001412 5DHH-NOP-SB-612111
15.00Consensusot_offOrthosteric Ligand6TPK-OT-Retosiban
15.00Consensussensory_offOrthosteric Ligandopsin_off
15.00Consensusvasopressin-ot_offOrthosteric Ligandot_off
14.81Single7E14Orforglipron7E14-GLP-1-Orforglipron-PubChem 156022738-Gs/&β;1/&γ;2
14.81Single7EZKCholecystokinin-87EZK-CCKA-Cholecystokinin-8-chim(NtGi1-Gs)/&β;1/&γ;2
14.81Single7SK5CXCL127SK5-ACKR3-CXCL12
14.81Single7W56Neuromedin-S7W56-NMUR1-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
14.81Single8DWGProenkephalin-A8DWG-MRGPRX1-Proenkephalin-A-ML382-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
14.81Single8IOCGamma-MSH8IOC-MC3-Gamma-MSH-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
14.81Single8SG1Chemerin-98SG1-CML1-Chemerin-9-Gi1/&β;1/&γ;2
14.81Consensusgi_cckOrthosteric Ligand7EZH-CCKA-Cholecystokinin-8-Gi1/&β;1/&γ;2 7F8V-CCKB-Gastrin-17-Gi2/&β;1/&γ;2
14.81Consensussst_offOrthosteric Ligandsst2_off
14.71Single8FLSAbaloparatide8FLS-PTH1-Abaloparatide-Gs/&β;1/&γ;2
14.63Consensusgs_class-b1Orthosteric Ligandgs_glucagon gs_vip-pacap gs_pth gs_calcitonin gs_crf
14.29Single1HZX11-cis-Retinal1HZX-Rhodopsin-11-cis-Retinal
14.29Single3NYA(S)-Alprenolol3NYA-β2-(S)-Alprenolol
14.29Single4YAYZD-71554YAY-AT1-ZD-7155
14.29Single5NDDAZ8838; Na5NDD-PAR2-AZ8838; Na
14.29Single6K42Dexmedetomidine6K42-α2b-Dexmedetomidine-Gi1/&β;1/&γ;2
14.29Single6VN7PACAP6VN7-VPAC1-PACAP-Gs/&β;1/&γ;2
14.29Single6Z10PubChem 1545855546Z10-Succinate-PubChem 154585554
14.29Single7E32Serotonin7E32-5-HT1D-Serotonin-Gi1/&β;1/&γ;2
14.29Single7E9GJNJ-404118137E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/&β;1/&γ;2
14.29Single7M3JNPS-2143; PO47M3J-CaS-NPS-2143; PO4
14.29Single7SK8CXCL127SK8-ACKR3-CXCL12-CCX662
14.29Single7T6TfMLFII7T6T-FPR1-ALX-fMLFII-Gi1/&β;1/&γ;2
14.29Single7UM55-CT7UM5-5-HT5A-5-CT-chim(NtGi1-Go)/&β;1/&γ;2
14.29Single7VVMPTH7VVM-PTH1-PTH-Gs/&β;1/&γ;2
14.29Single7W55Neuromedin-U-257W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
14.29Single7WQ3Galanin7WQ3-GAL1-Galanin-Gi1/&β;1/&γ;2
14.29Single7YACPaltusotine7YAC-SST2-Paltusotine-Gi1/&β;1/&γ;2
14.29Single8HS2Fab0468HS2-GPR20-Fab046
14.29Single8I7WGSK2560738I7W-HCA2-GSK256073-Gi1/&β;1/&γ;2
14.29Single8J18(3R)-3-hydroxydodecanoic acid8J18-GPR84-(3R)-3-hydroxydodecanoic acid-Gi1/&β;1/&γ;2
14.29Single8JGGBAM8-228JGG-MRGPRX1-BAM8-22-Gi1/&β;1/&γ;2
14.29Single8JIRSAR4258998JIR-GLP-1-SAR425899-chim(NtGi1-Gs)/&β;1/&γ;2
14.29Single8JJOAlprenolol8JJO-β2-Alprenolol
14.29Single8JLJT1AM8JLJ-TA1-T1AM-chim(NtGi1-Gs)/&β;1/&γ;2
14.29Single8K5DGSK2560738K5D-HCA2-GSK256073
14.29Single8W8ARO52563908W8A-TA1-RO5256390-chim(NtGi1L-Gs)/&β;1/&γ;2
14.29Single8WC7ZH86678WC7-TA1-ZH8667-chim(NtGi1-Gs)/&β;1/&γ;2
14.29Single8X63Mepyramine8X63-H1-Mepyramine
14.29Single8X64Desloratadine8X64-H1-Desloratadine
14.29Single8XJLPGF2-alpha8XJL-FP-alpha-PGF2-alpha-chim(NtGi2-Gs-CtGq)/&β;1/&γ;2
14.29Single8XZGApelin-138XZG-Apelin-Apelin-13-Gi1/&β;1/&γ;2
14.29Consensus5ht1d_onOrthosteric Ligand7E32-5-HT1D-Serotonin-Gi1/&β;1/&γ;2
14.29Consensus5ht2_offOrthosteric Ligand5ht2a_off 5ht2b_off 5ht2c_off
14.29Consensusamine_onOrthosteric Ligandadrenergic_on histamine_on muscarinic_on tar_on 5ht_on dopamine_on
14.29Consensuscck_offOrthosteric Ligandccka_off
14.29Consensusccka_offOrthosteric Ligand7F8Y-CCKA-Devazepide 7F8U-CCKA-Lintitript
14.29Consensusfsh_on_alloOther Ligand8I2G-FSH-Glycoprotein hormones alpha chain-Compound 716340-Gs/&β;1/&γ;2
14.29Consensusgal1_onOrthosteric Ligand7WQ3-GAL1-Galanin-Gi1/&β;1/&γ;2
14.29Consensusgi_5htOrthosteric Ligand7E2Y-5-HT1A-Serotonin-Gi1/&β;1/&γ;2 8JSP-5-HT1A-Ulotaront-Gi1/&β;1/&γ;2 7E32-5-HT1D-Serotonin-Gi1/&β;1/&γ;2 7E33-5-HT1E-BRL-54443-Gi1/&β;1/&γ;2 7EXD-5-HT1F-Lasmiditan-Gi1/&β;1/&γ;2 7XTA-5-HT4-Serotonin-Gi1/&β;1/&γ;2 7X5H-5-HT5A-5-CT-Gi1/&β;1/&γ;2 7E2Z-5-HT1A-Aripiprazole-Gi1/&β;1/&γ;2 8W8B-5-HT1A-SEP-363856-Gi1/&β;1/&γ;2
14.29Consensusgi_chemerinOrthosteric Ligand8SG1-CML1-Chemerin-9-Gi1/&β;1/&γ;2
14.29Consensusgi_galaninOrthosteric Ligand7WQ3-GAL1-Galanin-Gi1/&β;1/&γ;2
14.29Consensushcar_offOrthosteric Ligandsuccinate_off
14.29Consensusprostanoid_offOrthosteric Ligandep_off tp_off dp_off
14.29Consensussmo_offOrthosteric Ligand5L7I-SMO-Vismodegib 4O9R-SMO-Cyclopamine 4QIM-SMO-PubChem 24905375 4JKV-SMO-Taladegib (LY2940680)
14.29Consensussuccinate_offOrthosteric Ligand6RNK-Succinate-NF-56-EJ40 6Z10-Succinate-PubChem 154585554
14.29Consensustachykinin_offOrthosteric Ligandnk1_off
14.29Consensusvip-pacap_onOrthosteric Ligandvpac1_on vpac2_on pca1_on
13.89Single8JITMEDI03828JIT-Glucagon-MEDI0382-Gs/&β;1/&γ;2
13.79Single7AD3Alpha-factor mating pheromone7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
13.79Single7FINPeptide-20; GGL7FIN-GIP-Peptide-20; GGL-Gs/&β;1/&γ;2
13.79Single7WUIIP157WUI-ADGRG2-IP15-chim(NtGi1-Gs)/&β;1/&γ;2
13.79Consensusccr1_onOrthosteric Ligand7VL9-CCR1-CCL15(26-92)-Gi1/&β;1/&γ;2
13.79Consensusclass-d_onOrthosteric Ligandste2_on
13.79Consensusgi_class-dOrthosteric Ligandgi_ste
13.79Consensusgi_steOrthosteric Ligand7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
13.79Consensuspca1_onOrthosteric Ligand6M1I-PAC1-PACAP-Gs/&β;1/&γ;2
13.79Consensusste2_onOrthosteric Ligand7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
13.64Single5T1APubChem 68764898; PubChem 120931705T1A-CCR2-PubChem 68764898; PubChem 12093170
13.64Single5WIUNemonapride5WIU-D4-Nemonapride
13.64Single5WIVNemonapride5WIV-D4-Nemonapride-Na
13.64Single5YHLPubChem 1351213525YHL-EP4-PubChem 135121352
13.64Single5YWYONO-AE3-2085YWY-EP4-ONO-AE3-208
13.64Single5ZBQUR-MK-2995ZBQ-Y1-UR-MK-299
13.64Single5ZK3Quinuclidinyl benzilate hydrobromide5ZK3-M2-Quinuclidinyl benzilate hydrobromide
13.64Single6ME72-Phenylmelatonin6ME7-MT2-2-Phenylmelatonin
13.64Single6PS6Timolol6PS6-β2-Timolol
13.64Single7BB7Acyclovir triphosphate7BB7-V2-Acyclovir triphosphate-Gs/&β;1/&γ;2
13.64Single7EUOfMLF7EUO-FPR1-ALX-fMLF-Gi1/&β;1/&γ;2
13.64Single7M3JNPS-2143; PO47M3J-CaS-NPS-2143; PO4
13.64Single7T9NPubChem 6440787T9N-TSH-M22 Fab-PubChem 644078-Gs/&β;1/&γ;2
13.64Single8EFBOliceridine8EFB-μ-Oliceridine-Gi1/&β;1/&γ;2
13.64Single8GD9Rivenprost8GD9-EP4-Rivenprost-Gs/&β;1/&γ;2
13.64Single8HNLPS3724248HNL-CXCR3-PS372424-Gi1/&β;1/&γ;2
13.64Single8J19PubChem 1270454228J19-GPR84-PubChem 127045422-Gi1/&β;1/&γ;2
13.64Consensus5ht1_onOrthosteric Ligand5ht1a_on 5ht1d_on 5ht1e_on 5ht1f_on 5ht1b_on
13.64Consensus5ht2b_offOrthosteric Ligand6DRZ-5-HT2B-Methysergide 6DRX-5-HT2B-Lisuride
13.64Consensusccr2_off_alloOther Ligand5T1A-CCR2-PubChem 68764898; PubChem 12093170 6GPX-CCR2-MK0812
13.64Consensusd4_offOrthosteric Ligand5WIU-D4-Nemonapride
13.64Consensusd4_off_alloOrthosteric Ligand5WIV-D4-Nemonapride-Na
13.64Consensusep4_offOrthosteric Ligand5YWY-EP4-ONO-AE3-208 5YHL-EP4-PubChem 135121352
13.64Consensusep_offOrthosteric Ligandep4_off
13.33Single5MZPCaffeine5MZP-A2A-Caffeine-Na
13.33Single7VL9CCL15(26-92)7VL9-CCR1-CCL15(26-92)-Gi1/&β;1/&γ;2
13.33Single7Y35Abaloparatide7Y35-PTH1-Abaloparatide-Gs/&β;1/&γ;2
13.33Single8WCCCyclohexylammonium ion8WCC-TA1-Cyclohexylammonium ion
13.33Consensusvpac1_onOrthosteric Ligand8E3Y-VPAC1-PACAP27-Gs/&β;1/&γ;2 8E3Z-VPAC1-VIP-Gs/&β;1/&γ;2 6VN7-VPAC1-PACAP-Gs/&β;1/&γ;2
13.04Single3UONQuinuclidinyl benzilate hydrobromide3UON-M2-Quinuclidinyl benzilate hydrobromide
13.04Single4U15Tiotropium4U15-M3-Tiotropium
13.04Single5V54Methiothepin5V54-5-HT1B-Methiothepin
13.04Single5ZBHBMS-1938855ZBH-Y1-BMS-193885
13.04Single6O3CCholesterol6O3C-SMO-SAG21k-Cholesterol
13.04Single6OL9Tiotropium6OL9-M5-Tiotropium
13.04Single7AUESetmelanotide7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/&β;1/&γ;2
13.04Single7EPENAM5637EPE-mGlu-NAM563
13.04Single7EW4CYM55417EW4-S1P3-CYM5541-Gi1/&β;1/&γ;2
13.04Single7R0CAcyclovir triphosphate7R0C-V2-Acyclovir triphosphate-Arrestin2
13.04Single7SK7CXCL127SK7-ACKR3-CXCL12-CCX662
13.04Single7XBDGalanin7XBD-GAL2-Galanin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
13.04Single8G056-OAU8G05-GPR84-6-OAU-Gi1/&β;1/&γ;2
13.04Single8I2GCompound 7163408I2G-FSH-Glycoprotein hormones alpha chain-Compound 716340-Gs/&β;1/&γ;2
13.04Consensus5ht1_offOrthosteric Ligand5ht1b_off
13.04Consensus5ht1b_offOrthosteric Ligand5V54-5-HT1B-Methiothepin
13.04Consensusangiotensin_offOrthosteric Ligandat1_off at2_off
13.04Consensusccka_onOrthosteric Ligand7EZH-CCKA-Cholecystokinin-8-Gi1/&β;1/&γ;2 7XOV-CCKA-SR146131-Gs/&β;1/&γ;2
13.04Consensusgi_muscarinicOrthosteric Ligand7TRS-M4-Acetylcholine-Gi1/&β;1/&γ;2 7TRK-M4-Iperoxo-Gi1/&β;1/&γ;2 7V6A-M4-PubChem 9864275-Gi1/&β;1/&γ;2
13.04Consensusm3_offOrthosteric Ligand4U15-M3-Tiotropium 4U16-M3-N-Methyl Scopolamine 5ZHP-M3-PubChem 134828589
13.04Consensusm5_offOrthosteric Ligand6OL9-M5-Tiotropium
13.04Consensusmglu2_onOther Ligand7MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/&β;1/&γ;2 7E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/&β;1/&γ;2
13.04Consensusmuscarinic_offOrthosteric Ligandm2_off m3_off m4_off m5_off m1_off
13.04Consensusnpy1_offOrthosteric Ligand5ZBH-Y1-BMS-193885 5ZBQ-Y1-UR-MK-299
12.90Single6FJ3PTH6FJ3-PTH1-PTH
12.90Single6P9YPACAP6P9Y-PAC1-PACAP-Gs/&β;1/&γ;2
12.90Single7CZ5Somatoliberin7CZ5-GHRH-Somatoliberin-Gs/&β;1/&γ;2
12.90Consensusctlike_onOrthosteric Ligand6E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/&β;1/&γ;2; RAMP1 6UUN-CT Like (AM1)-Adrenomedullin-Gs/&β;1/&γ;2; RAMP2
12.90Consensusghrh_onOrthosteric Ligand7CZ5-GHRH-Somatoliberin-Gs/&β;1/&γ;2
12.50Single5CXVTiotropium5CXV-M1-Tiotropium
12.50Single5NX2GLP-1 (Truncated)5NX2-GLP-1-GLP-1 (Truncated)
12.50Single5X33BIIL2605X33-BLT1-BIIL260
12.50Single6AK3Dinoprostone IPGE26AK3-EP3-Dinoprostone IPGE2
12.50Single6DRYMethylergonovine6DRY-5-HT2B-Methylergonovine
12.50Single6LMKGlucagon6LMK-Glucagon-Glucagon-Gs/&β;1/&γ;2
12.50Single7DFPSpiperone7DFP-D2-Spiperone
12.50Single7K15MKD0467K15-BLT1-MKD046-Na
12.50Single7V68PubChem 576644067V68-M4-Iperoxo-PubChem 57664406-Gi1/&β;1/&γ;2
12.50Single7W0LPubChem 1227019087W0L-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
12.50Single7WC4Serotonin7WC4-5-HT2A-Serotonin
12.50Single7WCNAR2314537WCN-GPR119-AR231453-Gs/&β;1/&γ;2
12.50Single7WQ4Galanin7WQ4-GAL2-Galanin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
12.50Single7XKEBetahydroxyandrosterone7XKE-ADGRG2-Betahydroxyandrosterone-chim(NtGi1-Gs)/&β;1/&γ;2
12.50Single7XZ5Lysophosphatidylcholine7XZ5-GPR119-Lysophosphatidylcholine-Gs/&β;1/&γ;2
12.50Single8DWCProenkephalin-A8DWC-MRGPRX1-Proenkephalin-A-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
12.50Single8E9W2-Deoxycytidine8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
12.50Single8GCPPGE28GCP-EP4-PGE2-Gi1/&β;1/&γ;2
12.50Single8GEJEpinephrine8GEJ-β2-Epinephrine-Gs/&β;1/&γ;2
12.50Single8HQMNPGLY8HQM-GPR132-NPGLY-Gi1/&β;1/&γ;2
12.50Single8HSCFab0468HSC-GPR20-Fab046-Gi1/&β;1/&γ;2
12.50Single8JGFBAM8-228JGF-MRGPRX1-BAM8-22-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
12.50Consensusblt1_offOrthosteric Ligand7K15-BLT1-MKD046-Na
12.50Consensusblt_offOrthosteric Ligandblt1_off
12.50Consensusclass-c_onOther Ligandgabab_on mglu_on
12.50Consensusd2_offOrthosteric Ligand6CM4-D2-Risperidone 6LUQ-D2-Haloperidol 7DFP-D2-Spiperone
12.50Consensusgabab_offOther Ligand7C7S-GABAB1, GABAB2-CGP54626 7CUM-GABAB1, GABAB2-CGP54626-Phospholipid 6W2X-GABAB1, GABAB2-PubChem 5311042-PubChem 23727970
12.50Consensusgalanin_onOrthosteric Ligandgal2_on gal1_on
12.50Consensusgi_prostanoidOrthosteric Ligand8GCP-EP4-PGE2-Gi1/&β;1/&γ;2 8GDC-EP3-PGE2-Gi1/&β;1/&γ;2 8GCM-EP4-L902688-Gi1/&β;1/&γ;2
12.50Consensusglp2_onOrthosteric Ligand7D68-GLP-2-GLP-2-Gs/&β;1/&γ;2
12.50Consensusm1_offOrthosteric Ligand5CXV-M1-Tiotropium
12.50Consensusm4_onOrthosteric Ligand7TRS-M4-Acetylcholine-Gi1/&β;1/&γ;2 7TRK-M4-Iperoxo-Gi1/&β;1/&γ;2 8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/&β;1/&γ;2 7V6A-M4-PubChem 9864275-Gi1/&β;1/&γ;2
12.50Consensusprostanoid_onOrthosteric Ligandep_on fpa_on
12.50Consensusste2_onOrthosteric Ligand7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
12.20Consensusgs_calcitoninOrthosteric Ligandgs_ct gs_cgrp
12.12Single8FLTM-PTH(1-14)8FLT-PTH1-M-PTH(1-14)-Gs/&β;1/&γ;2
12.12Consensuscalcitonin_onOrthosteric Ligandct_on ctlike_on
12.00Single7XZ6APD6687XZ6-GPR119-APD668-Gs/&β;1/&γ;2
12.00Single8IULLatanoprost8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
12.00Single8K2XCXCL108K2X-CXCR3-CXCL10-Gi1/&β;1/&γ;2
12.00Consensusadgrg2_onOrthosteric Ligand7XKD-ADGRG2-Betahydroxyandrosterone-Gs/&β;1/&γ;2 7WUI-ADGRG2-IP15-chim(NtGi1-Gs)/&β;1/&γ;2
12.00Consensusep4_onOrthosteric Ligand7D7M-EP4-Dinoprostone-Gs/&β;1/&γ;1 8GCP-EP4-PGE2-Gi1/&β;1/&γ;2 8GD9-EP4-Rivenprost-Gs/&β;1/&γ;2 8GDA-EP4-L902688-Gs/&β;1/&γ;2
12.00Consensusfpa_onOrthosteric Ligand8IUK-FP-alpha-PGF2-alpha-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
12.00Consensusgs_prostanoidOrthosteric Ligand8IUK-FP-alpha-PGF2-alpha-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7CX2-EP2-PGE2-Gs/&β;1/&γ;2 7CX3-EP2-Taprenepag-Gs/&β;1/&γ;2 7D7M-EP4-Dinoprostone-Gs/&β;1/&γ;1 7CX4-EP2-Evatanepag-Gs/&β;1/&γ;2 8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
11.76Single6OY9All-trans-retinal6OY9-Rhodopsin-All-trans-retinal-Gt/&β;1/&γ;1
11.76Single6TQ9SB-4081246TQ9-OX1-SB-408124
11.76Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
11.76Single7VDMSubstance P7VDM-MRGPRX2-Substance P-Gi1/&β;1/&γ;2
11.76Single7XKDBetahydroxyandrosterone7XKD-ADGRG2-Betahydroxyandrosterone-Gs/&β;1/&γ;2
11.76Single8DPHLorcaserin8DPH-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
11.76Single8U4QREGN7663-Fab8U4Q-CXCR4-REGN7663-Fab-Cholesterol-Gi1/&β;1/&γ;2
11.76Consensushca2_on_alloOrthosteric Ligand8J6P-HCA2-Niacin-Compound 9n-Gi1/&β;1/&γ;2 8J6Q-HCA2-Beta-hydroxybutyrate-Compound 9n-Gi1/&β;1/&γ;2
11.54Single7YAEOctreotide7YAE-SST2-Octreotide-Gi1/&β;1/&γ;2
11.54Single8IQ4Carboprost8IQ4-FP-alpha-Carboprost-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
11.54Single8IUMTafluprost acid8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
11.11Single3C9M11-cis-Retinal3C9M-Rhodopsin-11-cis-Retinal
11.11Single6FUFAll-trans-retinal6FUF-Rhodopsin-All-trans-retinal-Go/&β;1/&γ;2
11.11Single6OIKLY21196206OIK-M2-Iperoxo-LY2119620-chim(NtGi1-Go)/&β;1/&γ;2
11.11Single7F23Dopamine7F23-D1-Dopamine-GDP-Gs/&β;1/&γ;2
11.11Single7MT8All-trans-retinal7MT8-Rhodopsin-All-trans-retinal-GRK1
11.11Single7MT9All-trans-retinal7MT9-Rhodopsin-All-trans-retinal-GRK1
11.11Single7MTAAll-trans-retinal7MTA-Rhodopsin-All-trans-retinal-GRK1
11.11Single7V6APubChem 98642757V6A-M4-PubChem 9864275-Gi1/&β;1/&γ;2
11.11Single7XMRSomatostatin-147XMR-SST2-Somatostatin-14-Gi1/&β;1/&γ;2
11.11Single8JGBConorfamide-Tx28JGB-MRGPRX1-Conorfamide-Tx2-Gi1/&β;1/&γ;2
11.11Single8JXTHistamine8JXT-H4-Histamine-PO4-Gi1/&β;1/&γ;2
11.11Single8POKHistamine8POK-H2-Histamine-Gs/&β;1/&γ;2
11.11Single8WC62-Phenylethylamine8WC6-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/&β;1/&γ;2
11.11Single8WC9ZH86518WC9-TA1-ZH8651-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
10.71Single6WHCGlu16 analog of GCG6WHC-Glucagon-Glu16 analog of GCG-Gs/&β;1/&γ;2
10.53Single1L9H11-cis-Retinal1L9H-Rhodopsin-11-cis-Retinal
10.53Single4MQTLY21196204MQT-M2-Iperoxo-LY2119620
10.53Single5TE520-Methanoretinal5TE5-Rhodopsin-20-Methanoretinal
10.53Single6U1NLY21196206U1N-M2-LY2119620-Arrestin2
10.53Single7E2YSerotonin7E2Y-5-HT1A-Serotonin-Gi1/&β;1/&γ;2
10.53Single7UL2SR486927UL2-NTS1-SR48692-Na
10.53Single7XP6Strychnine7XP6-T2R46-Strychnine-chim(Gs-CtGt3)/&β;1/&γ;2
10.53Single7YFCHistamine7YFC-H4-Histamine-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
10.53Single7YFDImetit7YFD-H4-Imetit-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
10.53Single7YS6Serotonin7YS6-5-HT6-Serotonin-chim(NtGi1-Gs)/&β;1/&γ;2
10.53Single8DPFLorcaserin8DPF-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
10.53Single8FX5Xanomeline8FX5-M4-Xanomeline-Xanomeline-Gi1/&β;1/&γ;2
10.53Single8H2GNiacin8H2G-HCA2-Niacin-Gi1/&β;1/&γ;2
10.53Single8HN8Histamine8HN8-H4-Histamine-Gi1/&β;1/&γ;2
10.53Single8ITFDMCHA8ITF-TAAR9-DMCHA-chim(NtGi1-Gs)/&β;1/&γ;2
10.53Single8JILNiacin8JIL-HCA2-Niacin-Gi1/&β;1/&γ;2
10.53Single8K5BNiacin8K5B-HCA2-Niacin
10.53Single8UNXEpinephrine8UNX-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
10.53Single8W89PEA8W89-TA1-PEA-chim(NtGi1L-Gs)/&β;1/&γ;2
10.53Single8WC3SEP-3638568WC3-TA1-SEP-363856-chim(NtGi1-Gs)/&β;1/&γ;2
10.53Single8X2K5YM8X2K-GPR3-5YM-chim(NtGi1-Gs)/&β;1/&γ;2
10.53Consensus5ht4_onOrthosteric Ligand7XT8-5-HT4-Serotonin-Gs/&β;1/&γ;2
10.53Consensusclass-t_onOrthosteric Ligandtaste2_on
10.53Consensusgs_class-tOrthosteric Ligandgs_taste
10.53Consensusgs_tasteOrthosteric Ligand7XP6-T2R46-Strychnine-chim(Gs-CtGt3)/&β;1/&γ;2
10.53Consensusm4_on_alloOther Ligand7TRP-M4-Iperoxo-LY2033298-Gi1/&β;1/&γ;2 7TRQ-M4-Iperoxo-VU0467154-Gi1/&β;1/&γ;2 7V68-M4-Iperoxo-PubChem 57664406-Gi1/&β;1/&γ;2
10.53Consensusmt2_onOrthosteric Ligand7VH0-MT2-Ramelteon-Gi1/&β;1/&γ;1
10.53Consensusnts1_off_alloOrthosteric Ligand7UL2-NTS1-SR48692-Na
10.53Consensustaste2_onOrthosteric Ligand7XP6-T2R46-Strychnine-chim(Gs-CtGt3)/&β;1/&γ;2
10.00Single2PED9-cis-Retinal2PED-Rhodopsin-9-cis-Retinal
10.00Single5DHHSB-6121115DHH-NOP-SB-612111
10.00Single6KUYPubChem 1457046436KUY-α2a-PubChem 145704643
10.00Single6OYAAll-trans-retinal6OYA-Rhodopsin-All-trans-retinal-Gt/&β;1/&γ;1
10.00Single7LJDDopamine7LJD-D1-Dopamine-Mevidalen-Gs/&β;1/&γ;1
10.00Single7T8XAcetylcholine7T8X-M2-Acetylcholine-chim(NtGi1-Go)/&β;1/&γ;2
10.00Single7T90Acetylcholine7T90-M2-Acetylcholine-chim(NtGi1-Go)/&β;1/&γ;2
10.00Single7YM8Oxymetazoline7YM8-Alpha1A-Oxymetazoline-chim(Gs-CtGq)/&β;1/&γ;2
10.00Single8A6CAll-trans-retinal8A6C-Rhodopsin-All-trans-retinal
10.00Single8A6DAll-trans-retinal8A6D-Rhodopsin-All-trans-retinal
10.00Single8A6EAll-trans-retinal8A6E-Rhodopsin-All-trans-retinal
10.00Single8DWHCompound-168DWH-MRGPRX1-Compound-16-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
10.00Single8GEAEpinephrine8GEA-β2-Epinephrine-Gs/&β;1/&γ;2
10.00Single8HOCImetit8HOC-H4-Imetit-Gi1/&β;1/&γ;2
10.00Single8IW4Spermidine8IW4-TAAR9-Spermidine-chim(NtGi1-Gs)/&β;1/&γ;2
10.00Single8IWESpermidine8IWE-TAAR9-Spermidine
10.00Single8U4PAMD31008U4P-CXCR4-AMD3100-Cholesterol-Gi1/&β;1/&γ;2
10.00Single8U8FPML8U8F-GPR3-PML-Gs/&β;1/&γ;2
10.00Consensus5ht2_onOrthosteric Ligand5ht2a_on 5ht2c_on
10.00Consensus5ht2c_onOrthosteric Ligand8DPF-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8DPG-5-HT2C-Psilocin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
10.00Consensusgi_histamineOrthosteric Ligand8HN8-H4-Histamine-Gi1/&β;1/&γ;2 8HOC-H4-Imetit-Gi1/&β;1/&γ;2
10.00Consensusgs_histamineOrthosteric Ligand7YFC-H4-Histamine-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7YFD-H4-Imetit-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
10.00Consensusgt_class-aOrthosteric Ligandgt_opsin
10.00Consensusgt_opsinOrthosteric Ligandgt_sensory
10.00Consensusgt_sensoryOrthosteric Ligand6OYA-Rhodopsin-All-trans-retinal-Gt/&β;1/&γ;1
10.00Consensush4_onOrthosteric Ligand7YFC-H4-Histamine-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7YFD-H4-Imetit-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
10.00Consensusm2_onOrthosteric Ligand7T8X-M2-Acetylcholine-chim(NtGi1-Go)/&β;1/&γ;2
10.00Consensusopsin_offOrthosteric Ligand1U19-Rhodopsin-11-cis-Retinal 2PED-Rhodopsin-9-cis-Retinal 5TE5-Rhodopsin-20-Methanoretinal
9.52Single3RZECidoxepin3RZE-H1-Cidoxepin
9.52Single4MQTIperoxo4MQT-M2-Iperoxo-LY2119620
9.52Single6A94Zotepine6A94-5-HT2A-Zotepine
9.52Single6WH4Methiothepin6WH4-5-HT2A-Methiothepin
9.52Single6WJCAtropine6WJC-M1-Atropine-Muscarinic toxin 7
9.52Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
9.52Single7T94Acetylcholine7T94-M2-Acetylcholine-PubChem 57664406-chim(NtGi1-Go)/&β;1/&γ;2
9.52Single7TRSAcetylcholine7TRS-M4-Acetylcholine-Gi1/&β;1/&γ;2
9.52Single8DPGPsilocin8DPG-5-HT2C-Psilocin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
9.52Single8GCML9026888GCM-EP4-L902688-Gi1/&β;1/&γ;2
9.52Single8HJ5PubChem 1390305318HJ5-MRGPRX1-PubChem 139030531-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
9.52Single8JLNT1AM8JLN-TA1-T1AM-Gs/&β;1/&γ;2
9.52Single8JSPUlotaront8JSP-5-HT1A-Ulotaront-Gi1/&β;1/&γ;2
9.52Single8UHBRO52563908UHB-TA1-RO5256390-Gs/&β;1/&γ;2
9.52Single8WC8ZH86518WC8-TA1-ZH8651-chim(NtGi1-Gs)/&β;1/&γ;2
9.52Consensus5ht2a_offOrthosteric Ligand6A94-5-HT2A-Zotepine 6WH4-5-HT2A-Methiothepin 7VOE-5-HT2A-Aripiprazole 7VOD-5-HT2A-Cariprazine 7WC8-5-HT2A-Lumateperone 6A93-5-HT2A-Risperidone
9.52Consensus5ht2a_onOrthosteric Ligand7RAN-5-HT2A-PubChem 164575847-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 6WHA-5-HT2A-DB13948-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
9.52Consensusgs_ctOrthosteric Ligand7TYN-CT-Calcitonin-1-Gs/&β;1/&γ;2 6NIY-CT-Adrenomedullin-Gs/&β;1/&γ;2 8F0J-CT-Pramlintide analogue san45-Gs/&β;1/&γ;2 7TYL-CT-Amylin-Gs/&β;1/&γ;2 8F0K-CT (AMY3)-Pramlintide analogue san385-Gs/&β;1/&γ;2; RAMP3
9.52Consensusm1_off_alloOrthosteric Ligand6WJC-M1-Atropine-Muscarinic toxin 7
9.38Single6NBILong-acting PTH analog6NBI-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2
9.09Single4DAJTiotropium4DAJ-M3-Tiotropium
9.09Single4MQSIperoxo4MQS-M2-Iperoxo
9.09Single4U14Tiotropium4U14-M3-Tiotropium
9.09Single4U16N-Methyl Scopolamine4U16-M3-N-Methyl Scopolamine
9.09Single5DSGTiotropium5DSG-M4-Tiotropium
9.09Single5YC8N-Methyl Scopolamine5YC8-M2-N-Methyl Scopolamine
9.09Single5ZK8N-Methyl Scopolamine5ZK8-M2-N-Methyl Scopolamine
9.09Single5ZKCN-Methyl Scopolamine5ZKC-M2-N-Methyl Scopolamine
9.09Single6DRZMethysergide6DRZ-5-HT2B-Methysergide
9.09Single6IIVDaltroban6IIV-TP-Daltroban
9.09Single6ORVTT-OAD26ORV-GLP-1-TT-OAD2-Gs/&β;1/&γ;2
9.09Single6WHADB139486WHA-5-HT2A-DB13948-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
9.09Single7F83PF-051904577F83-Ghrelin-PF-05190457
9.09Single7TRPIperoxo7TRP-M4-Iperoxo-LY2033298-Gi1/&β;1/&γ;2
9.09Single7VH0Ramelteon7VH0-MT2-Ramelteon-Gi1/&β;1/&γ;1
9.09Single7WC8Lumateperone7WC8-5-HT2A-Lumateperone
9.09Single8JT8(R)-IHCH-71798JT8-5-HT2A-(R)-IHCH-7179
9.09Consensus5ht1a_onOrthosteric Ligand8JSP-5-HT1A-Ulotaront-Gi1/&β;1/&γ;2 7E2Z-5-HT1A-Aripiprazole-Gi1/&β;1/&γ;2 8W8B-5-HT1A-SEP-363856-Gi1/&β;1/&γ;2 7E2Y-5-HT1A-Serotonin-Gi1/&β;1/&γ;2
9.09Consensusgo_muscarinicOrthosteric Ligand8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/&β;1/&γ;2 7T8X-M2-Acetylcholine-chim(NtGi1-Go)/&β;1/&γ;2
9.09Consensusgq_amineOrthosteric Ligandgq_muscarinic gq_histamine
9.09Consensushistamine_onOrthosteric Ligandh1_on h4_on
9.09Consensusm2_on_alloOrthosteric Ligand7T94-M2-Acetylcholine-PubChem 57664406-chim(NtGi1-Go)/&β;1/&γ;2 6OIK-M2-Iperoxo-LY2119620-chim(NtGi1-Go)/&β;1/&γ;2
9.09Consensusm4_offOrthosteric Ligand5DSG-M4-Tiotropium
9.09Consensusm4_on_alloOrthosteric Ligand7TRP-M4-Iperoxo-LY2033298-Gi1/&β;1/&γ;2 7TRQ-M4-Iperoxo-VU0467154-Gi1/&β;1/&γ;2 7V68-M4-Iperoxo-PubChem 57664406-Gi1/&β;1/&γ;2
9.09Consensusmuscarinic_onOrthosteric Ligandm2_on m3_on m4_on m1_on
9.09Consensustp_offOrthosteric Ligand6IIV-TP-Daltroban 6IIU-TP-Ramatroban
8.82Single7TYWCalcitonin-17TYW-CT (AMY1)-Calcitonin-1-Gs/&β;1/&γ;2; RAMP1
8.70Single4WW3All-trans-retinal4WW3-Rhodopsin-All-trans-retinal
8.70Single6LUQHaloperidol6LUQ-D2-Haloperidol
8.70Single6M9TMisoprostol-FA6M9T-EP3-Misoprostol-FA
8.70Single6OIKIperoxo6OIK-M2-Iperoxo-LY2119620-chim(NtGi1-Go)/&β;1/&γ;2
8.70Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
8.70Single7TRKIperoxo7TRK-M4-Iperoxo-Gi1/&β;1/&γ;2
8.70Single7VOEAripiprazole7VOE-5-HT2A-Aripiprazole
8.70Single8E9ZIperoxo8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
8.70Single8EA0Iperoxo8EA0-M3-Iperoxo
8.70Single8GDAL9026888GDA-EP4-L902688-Gs/&β;1/&γ;2
8.70Single8SZICa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZI-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi3/&β;1/&γ;2
8.70Consensusgq_muscarinicOrthosteric Ligand6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/&β;1/&γ;2
8.70Consensusgs_muscarinicOrthosteric Ligand8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
8.70Consensusm1_onOrthosteric Ligand6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/&β;1/&γ;2
8.70Consensusm2_offOrthosteric Ligand5ZKB-M2-AF-DX 384 5ZKC-M2-N-Methyl Scopolamine 5ZK3-M2-Quinuclidinyl benzilate hydrobromide
8.70Consensusm3_onOrthosteric Ligand8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
8.57Single7TYFAmylin7TYF-CT (AMY1)-Amylin-Gs/&β;1/&γ;2; RAMP1
8.57Single7TYIAmylin7TYI-CT-Amylin-Gs/&β;1/&γ;2
8.57Single7TYNCalcitonin-17TYN-CT-Calcitonin-1-Gs/&β;1/&γ;2
8.33Single6OIJIperoxo6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/&β;1/&γ;2
8.33Single7P2L4YI7P2L-mGlu5-4YI
8.33Single7TRQIperoxo7TRQ-M4-Iperoxo-VU0467154-Gi1/&β;1/&γ;2
8.33Single7TYHCalcitonin-17TYH-CT (AMY2)-Calcitonin-1-Gs/&β;1/&γ;2; RAMP2
8.33Single8GDBPGE28GDB-EP4-PGE2-Gs/&β;1/&γ;2
8.33Single8IUKPGF2-alpha8IUK-FP-alpha-PGF2-alpha-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
8.33Single8JD5BQI; HZE; PEF8JD5-mGlu2; mGlu4-Glutamate-BQI; HZE; PEF-Gi1/&β;1/&γ;2
8.33Single8X79MRE-2698X79-I2-MRE-269-Gs/&β;1/&γ;2
8.33Single8XJMLatanoprost8XJM-FP-alpha-Latanoprost-chim(NtGi2-Gs-CtGq)/&β;1/&γ;2
8.11Single7TZFAmylin7TZF-CT (AMY3)-Amylin-Gs/&β;1/&γ;2; RAMP3
8.11Single8F0KPramlintide analogue san3858F0K-CT (AMY3)-Pramlintide analogue san385-Gs/&β;1/&γ;2; RAMP3
8.00Single6IIURamatroban6IIU-TP-Ramatroban
8.00Single7D7MDinoprostone7D7M-EP4-Dinoprostone-Gs/&β;1/&γ;1
8.00Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/&β;1/&γ;2
8.00Consensusep_onOrthosteric Ligandep4_on ep2_on ep3_on
7.89Single7TYYCalcitonin-17TYY-CT (AMY2)-Calcitonin-1-Gs/&β;1/&γ;2; RAMP2
7.89Single9AUCCalcitonin gene-related peptide-19AUC-CT-Calcitonin gene-related peptide-1-Gs/&β;1/&γ;2; RAMP1
7.69Single6D32Cyclopamine6D32-SMO-Cyclopamine-Cyclopamine
7.69Single6D35Cholesterol6D35-SMO-Cholesterol
7.69Single6N51Quisqualate6N51-mGlu5; mGlu5-Quisqualate
7.69Single6N51Quisqualate6N51-mGlu5; mGlu5-Quisqualate
7.69Single6UO8SKF975416UO8-GABAB1, GABAB2-SKF97541-GS39783
7.69Single6UO9SKF975416UO9-GABAB1, GABAB2-SKF97541
7.69Single6W2XPubChem 53110426W2X-GABAB1, GABAB2-PubChem 5311042-PubChem 23727970
7.69Single6W2YPubChem 53110426W2Y-GABAB1; GABAB1-PubChem 5311042-PubChem 23727970
7.69Single6W2YPubChem 53110426W2Y-GABAB1; GABAB1-PubChem 5311042-PubChem 23727970
7.69Single7C7QBaclofen7C7Q-GABAB1, GABAB2-Baclofen-PubChem 7023848
7.69Single7C7SCGP546267C7S-GABAB1, GABAB2-CGP54626
7.69Single7CUMCGP546267CUM-GABAB1, GABAB2-CGP54626-Phospholipid
7.69Single7CX4Evatanepag7CX4-EP2-Evatanepag-Gs/&β;1/&γ;2
7.69Single7DD5Ca37DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
7.69Single7DD5Ca7DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
7.69Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
7.69Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
7.69Single7DGEQuisqualate7DGE-mGlu1; mGlu1-Quisqualate
7.69Single7DTTCa7DTT-CaS-Ca-Ca
7.69Single7DTTCa7DTT-CaS-Ca-Ca
7.69Single7DTUTryptophan7DTU-CaS-Tryptophan
7.69Single7DTUTryptophan7DTU-CaS-Tryptophan
7.69Single7DTVCa7DTV-CaS-Ca-Ca; Tryptophan
7.69Single7DTVCa; Tryptophan7DTV-CaS-Ca-Ca; Tryptophan
7.69Single7DTVCa7DTV-CaS-Ca-Ca; Tryptophan
7.69Single7DTVCa; Tryptophan7DTV-CaS-Ca-Ca; Tryptophan
7.69Single7E6TCa7E6T-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
7.69Single7E6TCa; Ca; Cyclomethyltryptophan; PO47E6T-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
7.69Single7E6TCa7E6T-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
7.69Single7E6TCa; Ca; Cyclomethyltryptophan; PO47E6T-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
7.69Single7E9GEglumetad7E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/&β;1/&γ;2
7.69Single7E9GEglumetad7E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/&β;1/&γ;2
7.69Single7E9HPhosphoserine7E9H-mGlu4; mGlu4-Phosphoserine-Gi3/&β;1/&γ;2
7.69Single7E9HPhosphoserine7E9H-mGlu4; mGlu4-Phosphoserine-Gi3/&β;1/&γ;2
7.69Single7EB2Baclofen7EB2-GABAB1, GABAB2-Baclofen-rac-BHFF-Gi1/&β;1/&γ;2
7.69Single7EPBEglumetad7EPB-mGlu2; mGlu2-Eglumetad
7.69Single7EPBEglumetad7EPB-mGlu2; mGlu2-Eglumetad
7.69Single7FD8Quisqualate7FD8-mGlu5; mGlu5-Quisqualate
7.69Single7FD8Quisqualate7FD8-mGlu5; mGlu5-Quisqualate
7.69Single7FD9LY3414957FD9-mGlu5; mGlu5-LY341495
7.69Single7FD9LY3414957FD9-mGlu5; mGlu5-LY341495
7.69Single7FIHhCG7FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/&β;1/&γ;2
7.69Single7FIIhCG7FII-LH-hCG-6fuf
7.69Single7M3ECa; Ca; Tryptophan; NPS-2143; PO47M3E-CaS-Ca; Ca; Tryptophan; NPS-2143; PO4
7.69Single7M3ECa; Ca; Tryptophan; NPS-2143; PO47M3E-CaS-Ca; Ca; Tryptophan; NPS-2143; PO4
7.69Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
7.69Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
7.69Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
7.69Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
7.69Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
7.69Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
7.69Single7MTQLY3414957MTQ-mGlu2; mGlu2-LY341495
7.69Single7MTQLY3414957MTQ-mGlu2; mGlu2-LY341495
7.69Single7MTRGlutamate7MTR-mGlu2; mGlu2-Glutamate-ADX55164
7.69Single7MTRGlutamate7MTR-mGlu2; mGlu2-Glutamate-ADX55164
7.69Single7MTSGlutamate7MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/&β;1/&γ;2
7.69Single7MTSGlutamate7MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/&β;1/&γ;2
7.69Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
7.69Single7SILCa7SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
7.69Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
7.69Single7SILCa7SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
7.69Single7SIMCa7SIM-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
7.69Single7SIMCa; Ca; Cyclomethyltryptophan; PO47SIM-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
7.69Single7SIMCa7SIM-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
7.69Single7SIMCa; Ca; Cyclomethyltryptophan; PO47SIM-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
7.69Single7T9NM22 Fab7T9N-TSH-M22 Fab-PubChem 644078-Gs/&β;1/&γ;2
7.69Single7WI6LY3414957WI6-mGlu3; mGlu3-LY341495
7.69Single7WI6LY3414957WI6-mGlu3; mGlu3-LY341495
7.69Single7WI8LY3414957WI8-mGlu3; mGlu3-LY341495
7.69Single7WI8LY3414957WI8-mGlu3; mGlu3-LY341495
7.69Single7WIHLY27941937WIH-mGlu3; mGlu3-LY2794193
7.69Single7WIHLY27941937WIH-mGlu3; mGlu3-LY2794193
7.69Single7XW6M22 Fab7XW6-TSH-M22 Fab-ML109-Gs/&β;1/&γ;2
7.69Single7XW7K1-707XW7-TSH-K1-70
7.69Single8IQ6Latanoprost8IQ6-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
7.69Single8JCULY3414958JCU-mGlu2; mGlu3-LY341495
7.69Single8JCULY3414958JCU-mGlu2; mGlu3-LY341495
7.69Single8JCVLY3414958JCV-mGlu2; mGlu3-LY341495
7.69Single8JCVLY3414958JCV-mGlu2; mGlu3-LY341495
7.69Single8JCWLY3414958JCW-mGlu2; mGlu3-LY341495
7.69Single8JCWLY3414958JCW-mGlu2; mGlu3-LY341495
7.69Single8JCXLY3414958JCX-mGlu2; mGlu3-LY341495
7.69Single8JCXLY3414958JCX-mGlu2; mGlu3-LY341495
7.69Single8JCYLY3414958JCY-mGlu2; mGlu3-LY341495
7.69Single8JCYLY3414958JCY-mGlu2; mGlu3-LY341495
7.69Single8JCZLY3414958JCZ-mGlu2; mGlu3-LY341495
7.69Single8JCZLY3414958JCZ-mGlu2; mGlu3-LY341495
7.69Single8JD0Glutamate8JD0-mGlu2; mGlu3-Glutamate-J9R
7.69Single8JD1Glutamate8JD1-mGlu2; mGlu3-Glutamate
7.69Single8JD1Glutamate8JD1-mGlu2; mGlu3-Glutamate
7.69Single8JD2Glutamate8JD2-mGlu2; mGlu3-Glutamate
7.69Single8JD2Glutamate8JD2-mGlu2; mGlu3-Glutamate
7.69Single8JD3Glutamate8JD3-mGlu2; mGlu3-Glutamate-HZR; PEF-Gi1/&β;1/&γ;2
7.69Single8JD3Glutamate8JD3-mGlu2; mGlu3-Glutamate-HZR; PEF-Gi1/&β;1/&γ;2
7.69Single8JD4Glutamate8JD4-mGlu2; mGlu4-Glutamate
7.69Single8JD4Glutamate8JD4-mGlu2; mGlu4-Glutamate
7.69Single8JD5Glutamate8JD5-mGlu2; mGlu4-Glutamate-BQI; HZE; PEF-Gi1/&β;1/&γ;2
7.69Single8JD5Glutamate8JD5-mGlu2; mGlu4-Glutamate-BQI; HZE; PEF-Gi1/&β;1/&γ;2
7.69Single8JD6Phosphoserine8JD6-mGlu4; mGlu4-Phosphoserine-N-(3-chlorophenyl)pyridine-2-carboxamide-Gi3/&β;1/&γ;2
7.69Single8JD6Phosphoserine8JD6-mGlu4; mGlu4-Phosphoserine-N-(3-chlorophenyl)pyridine-2-carboxamide-Gi3/&β;1/&γ;2
7.69Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
7.69Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
7.69Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
7.69Single8SZGCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-chim(NtGi1-Gq)/&β;1/&γ;2
7.69Single8SZGCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-chim(NtGi1-Gq)/&β;1/&γ;2
7.69Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/&β;1/&γ;2
7.69Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/&β;1/&γ;2
7.69Single8SZICa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZI-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi3/&β;1/&γ;2
7.69Single8SZICa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZI-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi3/&β;1/&γ;2
7.69Single8T7HQuisqualate8T7H-mGlu5; mGlu5-Quisqualate
7.69Single8T7HQuisqualate8T7H-mGlu5; mGlu5-Quisqualate
7.69Single8T8MQuisqualate8T8M-mGlu5; mGlu5-Quisqualate
7.69Single8T8MQuisqualate8T8M-mGlu5; mGlu5-Quisqualate
7.69Single8TAOQuisqualate8TAO-mGlu5; mGlu5-Quisqualate-CDPPB
7.69Single8TAOQuisqualate8TAO-mGlu5; mGlu5-Quisqualate-CDPPB
7.69Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
7.69Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
7.69Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
7.69Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
7.69Single8XJOU466198XJO-TP-U46619-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
7.69Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
7.69Single9AXFCa9AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
7.69Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
7.69Single9AXFCa9AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
7.69Single9AYFCa9AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/&β;1/&γ;2
7.69Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/&β;1/&γ;2
7.69Consensusclass-c_offOrthosteric Ligandgabab_off mglu_off
7.69Consensusclass-c_offOrthosteric Ligandgabab_off mglu_off
7.69Consensusclass-c_onOrthosteric Ligandgabab_on mglu_on
7.69Consensusclass-c_onOrthosteric Ligandgabab_on mglu_on
7.69Consensusep2_onOrthosteric Ligand7CX4-EP2-Evatanepag-Gs/&β;1/&γ;2 7CX2-EP2-PGE2-Gs/&β;1/&γ;2 7CX3-EP2-Taprenepag-Gs/&β;1/&γ;2
7.69Consensusfsh_on_alloOrthosteric Ligand8I2G-FSH-Glycoprotein hormones alpha chain-Compound 716340-Gs/&β;1/&γ;2
7.69Consensusgabab_offOrthosteric Ligand7C7S-GABAB1, GABAB2-CGP54626 7CUM-GABAB1, GABAB2-CGP54626-Phospholipid 6W2X-GABAB1, GABAB2-PubChem 5311042-PubChem 23727970
7.69Consensusgabab_onOrthosteric Ligand7EB2-GABAB1, GABAB2-Baclofen-rac-BHFF-Gi1/&β;1/&γ;2
7.69Consensusgi_class-cOrthosteric Ligandgi_mglu gi_gaba
7.69Consensusgi_class-cOrthosteric Ligandgi_mglu gi_gaba
7.69Consensusgi_gabaOrthosteric Ligand7EB2-GABAB1, GABAB2-Baclofen-rac-BHFF-Gi1/&β;1/&γ;2
7.69Consensusgi_mgluOrthosteric Ligand7E9H-mGlu4; mGlu4-Phosphoserine-Gi3/&β;1/&γ;2 8JD6-mGlu4; mGlu4-Phosphoserine-N-(3-chlorophenyl)pyridine-2-carboxamide-Gi3/&β;1/&γ;2
7.69Consensusgi_mgluOrthosteric Ligand7E9H-mGlu4; mGlu4-Phosphoserine-Gi3/&β;1/&γ;2 8JD6-mGlu4; mGlu4-Phosphoserine-N-(3-chlorophenyl)pyridine-2-carboxamide-Gi3/&β;1/&γ;2
7.69Consensusgphr_onOrthosteric Ligandlh_on tsh_on
7.69Consensusgs_gphrOrthosteric Ligand7T9I-TSH-TSH-Gs/&β;1/&γ;2 7FIG-LH-hCG-chim(NtGi1L-Gs)/&β;1/&γ;2
7.69Consensusgs_proteinOrthosteric Ligandgs_gphr
7.69Consensuslh_onOrthosteric Ligand7FIG-LH-hCG-chim(NtGi1L-Gs)/&β;1/&γ;2
7.69Consensuslh_on_alloOrthosteric Ligand7FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/&β;1/&γ;2
7.69Consensusmglu2_offOrthosteric Ligand7MTQ-mGlu2; mGlu2-LY341495
7.69Consensusmglu2_offOrthosteric Ligand7MTQ-mGlu2; mGlu2-LY341495
7.69Consensusmglu2_onOrthosteric Ligand7MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/&β;1/&γ;2 7E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/&β;1/&γ;2
7.69Consensusmglu2_onOrthosteric Ligand7MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/&β;1/&γ;2 7E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/&β;1/&γ;2
7.69Consensusmglu3_offOrthosteric Ligand7WI8-mGlu3; mGlu3-LY341495 7WIH-mGlu3; mGlu3-LY2794193
7.69Consensusmglu3_offOrthosteric Ligand7WI8-mGlu3; mGlu3-LY341495 7WIH-mGlu3; mGlu3-LY2794193
7.69Consensusmglu4_onOrthosteric Ligand7E9H-mGlu4; mGlu4-Phosphoserine-Gi3/&β;1/&γ;2 8JD6-mGlu4; mGlu4-Phosphoserine-N-(3-chlorophenyl)pyridine-2-carboxamide-Gi3/&β;1/&γ;2
7.69Consensusmglu4_onOrthosteric Ligand7E9H-mGlu4; mGlu4-Phosphoserine-Gi3/&β;1/&γ;2 8JD6-mGlu4; mGlu4-Phosphoserine-N-(3-chlorophenyl)pyridine-2-carboxamide-Gi3/&β;1/&γ;2
7.69Consensusmglu5_offOrthosteric Ligand7FD9-mGlu5; mGlu5-LY341495
7.69Consensusmglu5_offOrthosteric Ligand7FD9-mGlu5; mGlu5-LY341495
7.69Consensusmglu_offOrthosteric Ligandmglu2_off mglu3_off mglu5_off
7.69Consensusmglu_offOrthosteric Ligandmglu2_off mglu3_off mglu5_off
7.69Consensusmglu_onOrthosteric Ligandmglu2_on mglu4_on
7.69Consensusmglu_onOrthosteric Ligandmglu2_on mglu4_on
7.69Consensussmo_off_alloOther Ligand6D32-SMO-Cyclopamine-Cyclopamine
7.69Consensustsh_onOrthosteric Ligand7T9I-TSH-TSH-Gs/&β;1/&γ;2
7.69Consensustsh_on_alloOrthosteric Ligand7XW5-TSH-TSH-ML109-Gs/&β;1/&γ;2
7.50Single8F2APramlintide analogue san3858F2A-CT (AMY3)-Pramlintide analogue san385-Gs/&β;1/&γ;2; RAMP3
7.41Single5EE7MK08935EE7-Glucagon-MK0893
7.14Single7CX3Taprenepag7CX3-EP2-Taprenepag-Gs/&β;1/&γ;2
7.14Single7DD6Ca7DD6-CaS-Ca-Ca; Ca; Tryptophan
7.14Single7DD6Ca; Ca; Tryptophan7DD6-CaS-Ca-Ca; Ca; Tryptophan
7.14Single7DD6Ca7DD6-CaS-Ca-Ca; Ca; Tryptophan
7.14Single7DD6Ca; Ca; Tryptophan7DD6-CaS-Ca-Ca; Ca; Tryptophan
7.14Single7DD7Ca7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
7.14Single7DD7Ca7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
7.14Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
7.14Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
7.14Single7TYOCalcitonin7TYO-CT-Calcitonin-Gs/&β;1/&γ;2
7.14Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/&β;1/&γ;2
7.14Single9AYFCa9AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/&β;1/&γ;2
6.98Single8F2BPramlintide analogue san458F2B-CT (AMY3)-Pramlintide analogue san45-Gs/&β;1/&γ;2; RAMP3
6.67Single7KNUCalcitonin gene-related peptide-17KNU-CT Like-Calcitonin gene-related peptide-1-RAMP1
6.67Single7T9MCS-17 Antibody7T9M-TSH-CS-17 Antibody
6.67Single8F0JPramlintide analogue san458F0J-CT-Pramlintide analogue san45-Gs/&β;1/&γ;2
6.45Single6NIYAdrenomedullin6NIY-CT-Adrenomedullin-Gs/&β;1/&γ;2
6.25Single4A4MAll-trans-retinal4A4M-Rhodopsin-All-trans-retinal-Gt(CT)
6.25Single5EN0All-trans-retinal5EN0-Rhodopsin-All-trans-retinal-Gt(CT)
6.25Single6O3CCholesterol6O3C-SMO-SAG21k-Cholesterol
6.25Single6W25Ca6W25-MC4-SHU9119-Ca
6.25Single7FIGhCG7FIG-LH-hCG-chim(NtGi1L-Gs)/&β;1/&γ;2
6.25Single7UTZTR14027UTZ-TSH-TR1402-PubChem 644078-Gs/&β;1/&γ;2
6.25Single7XW5TSH7XW5-TSH-TSH-ML109-Gs/&β;1/&γ;2
6.25Single7ZI0Cholesterol7ZI0-SMO-SAG-Cholesterol
6.25Single8TLMAnti-murine CCR8 antibody8TLM-CCR8-Anti-murine CCR8 antibody
6.25Single8WCBCyclohexylammonium ion8WCB-TA1-Cyclohexylammonium ion-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
6.25Consensusccr8_offOrthosteric Ligand8TLM-CCR8-Anti-murine CCR8 antibody
5.88Single3PXOAll-trans-retinal3PXO-Rhodopsin-All-trans-retinal
5.88Single5DYSAll-trans-retinal5DYS-Rhodopsin-All-trans-retinal
5.88Single5L7DCholesterol5L7D-SMO-Cholesterol
5.88Single7T9ITSH7T9I-TSH-TSH-Gs/&β;1/&γ;2
5.88Single8I2GGlycoprotein hormones alpha chain8I2G-FSH-Glycoprotein hormones alpha chain-Compound 716340-Gs/&β;1/&γ;2
5.88Single8SZICa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZI-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi3/&β;1/&γ;2
5.56Single2HPYAll-trans-retinal2HPY-Rhodopsin-All-trans-retinal
5.56Single7MTBAll-trans-retinal7MTB-Rhodopsin-All-trans-retinal-GRK1
5.56Single7TYLAmylin7TYL-CT-Amylin-Gs/&β;1/&γ;2
5.56Single7TYXAmylin7TYX-CT (AMY2)-Amylin-Gs/&β;1/&γ;2; RAMP2
5.56Single7Y14Beta-alanine7Y14-MRGPRD-Beta-alanine
5.56Single8IWM2-Phenylethylamine8IWM-TAAR9-2-Phenylethylamine
5.56Single8WC5Tetramethylammonium ion8WC5-TA1-Tetramethylammonium ion-chim(NtGi1-Gs)/&β;1/&γ;2
5.56Consensussensory_onOrthosteric Ligandopsin_on
5.26Single2ZIY11-cis-Retinal2ZIY-Rhodopsin-11-cis-Retinal
5.26Single3PQRAll-trans-retinal3PQR-Rhodopsin-All-trans-retinal-Gt(CT)
5.26Single7F61Cholesterol7F61-H3-PF-03654746-Cholesterol
5.26Single7Y12Beta-alanine7Y12-MRGPRD-Beta-alanine-Gi1/&β;1/&γ;2
5.26Single8DPILorcaserin8DPI-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
5.26Single8IU2Retinal8IU2-Opsin1LW-Retinal-Gi1/&β;1/&γ;2
5.26Single8IW72-Phenylethylamine8IW7-TAAR9-2-Phenylethylamine-chim(NtGi1-Gs)/&β;1/&γ;2
5.26Consensusgip_on_alloOther Ligand7RBT-GIP-Tirzepatide-PubChem 163183774-chim(NtGi1-Gs)/&β;1/&γ;2
5.26Consensush3_on_alloOther Ligand7F61-H3-PF-03654746-Cholesterol
5.26Consensusopsin_onOrthosteric Ligand6OYA-Rhodopsin-All-trans-retinal-Gt/&β;1/&γ;1
5.00Single1U1911-cis-Retinal1U19-Rhodopsin-11-cis-Retinal
5.00Single2G87All-trans-retinal2G87-Rhodopsin-All-trans-retinal
5.00Single2I3511-cis-Retinal2I35-Rhodopsin-11-cis-Retinal
5.00Single3AYMAll-trans-retinal3AYM-Rhodopsin-All-trans-retinal
5.00Single7DFLHistamine7DFL-H1-Histamine-chim(NtGi1L-Gq)/&β;1/&γ;2
5.00Single7V68Iperoxo7V68-M4-Iperoxo-PubChem 57664406-Gi1/&β;1/&γ;2
5.00Single7XKFBetahydroxyandrosterone7XKF-ADGRG2-Betahydroxyandrosterone-Gs/&β;1/&γ;2
5.00Single8W8BSEP-3638568W8B-5-HT1A-SEP-363856-Gi1/&β;1/&γ;2
5.00Consensusgq_histamineOrthosteric Ligand7DFL-H1-Histamine-chim(NtGi1L-Gq)/&β;1/&γ;2
5.00Consensush1_onOrthosteric Ligand7DFL-H1-Histamine-chim(NtGi1L-Gq)/&β;1/&γ;2
4.76Single2Z7311-cis-Retinal2Z73-Rhodopsin-11-cis-Retinal
4.76Single3AYN9-cis-Retinal3AYN-Rhodopsin-9-cis-Retinal
4.76Single4XNVBPTU4XNV-P2Y1-BPTU
4.76Single7WV9ZCZ0117WV9-CB1-PubMed 104895-ZCZ011-Gi2/&β;1/&γ;2
4.76Consensuscb1_on_alloOther Ligand7WV9-CB1-PubMed 104895-ZCZ011-Gi2/&β;1/&γ;2
4.76Consensussmo_on_alloOther Ligand6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
4.55Single7VODCariprazine7VOD-5-HT2A-Cariprazine
4.55Single7VVOPTH7VVO-PTH1-PTH-Gs/&β;1/&γ;2
4.55Single8HNMVUF112228HNM-CXCR3-VUF11222-Gi1/&β;1/&γ;2
4.55Single8IYXYL-3658IYX-GPR34-YL-365
4.17Single5CGCHTL142425CGC-mGlu5-HTL14242
4.17Single8GDCPGE28GDC-EP3-PGE2-Gi1/&β;1/&γ;2
4.17Consensusep3_onOrthosteric Ligand8GDC-EP3-PGE2-Gi1/&β;1/&γ;2
3.70Single5CGDHTL142425CGD-mGlu5-HTL14242
3.70Single7CX2PGE27CX2-EP2-PGE2-Gs/&β;1/&γ;2
3.33Single7SHEPI; PE7SHE-GPR158-PI; PE

PDB Summary
PDB 7YU5
Class A
SubFamily Lipid
Type Lysophospholipid (LPA)
SubType LPA1
Species Homo sapiens
Ligand ONO-0740556
Other Ligand(s) -
Protein Partners Gi1/Beta1/Gamma2
PDB Resolution 3.7
Date 2022-10-05
D.O.I. 10.1038/s41467-022-33121-2
Net Summary
Imin 2.95
Number of Linked Nodes 862
Number of Links 1068
Number of Hubs 187
Number of Links mediated by Hubs 681
Number of Communities 25
Number of Nodes involved in Communities 241
Number of Links involved in Communities 360
Path Summary
Number Of Nodes in MetaPath 93
Number Of Links MetaPath 92
Number of Shortest Paths 4179126
Length Of Smallest Path 3
Average Path Length 45.6845
Length of Longest Path 74
Minimum Path Strength 1.145
Average Path Strength 6.71417
Maximum Path Strength 31.16
Minimum Path Correlation 0.7
Average Path Correlation 0.993191
Maximum Path Correlation 1
Minimum % Of Corr. Nodes 1.75439
Average % Of Corr. Nodes 30.4927
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 51.4658
Maximum Path Hubs % 100
AnnotationTypeLinks
Gene OntologyMolecular Function
Gene OntologyBiological Process
Gene OntologyCellular Component
SCOP2Domain Identifier
SCOP2Family Identifier
Membrane Protein Annotations-• Orientations of Proteins in Membranes database (OPM)   • Protein Data Bank of Transmembrane Proteins (PDBTM)   • MemProtMD


Details about the values in these tables can be found in the corresponding documentation page .
CodeK6L
PDB ResiduesL:L:?1
Environment DetailsOpen EMBL-EBI Page
CodeK6L
Name[(2~{R})-2-[5-(2-hexylphenyl)pentanoylamino]-3-oxidanyl-propyl] dihydrogen phosphate
Synonyms
Identifier[(2~{R})-2-[5-(2-hexylphenyl)pentanoylamino]-3-oxidanyl-propyl] dihydrogen phosphate
FormulaC20 H34 N O6 P
Molecular Weight415.461
SMILESCCCCCCc1ccccc1CCCCC(=O)N[C@H](CO)COP(=O)(O)O
PubChem141702624
Formal Charge0
Total Atoms62
Total Chiral Atoms1
Total Bonds62
Total Aromatic Bonds6

PDBsumOpen PDBsum Page
ChainB
ProteinG Protein β Sub unit
UniProtP54311
Sequence
>7YU5_Chain_B
ELDQLRQEA EQLKNQIRD ARKACADAT LSQITNNID PVGRIQMRT 
RRTLRGHLA KIYAMHWGT DSRLLVSAS QDGKLIIWD SYTTNKVHA 
IPLRSSWVM TCAYAPSGN YVACGGLDN ICSIYNLKT REGNVRVSR 
ELAGHTGYL SCCRFLDDN QIVTSSGDT TCALWDIET GQQTTTFTG 
HTGDVMSLS LAPDTRLFV SGACDASAK LWDVREGMC RQTFTGHES 
DINAICFFP NGNAFATGS DDATCRLFD LRADQELMT YSHDNIICG 
ITSVSFSKS GRLLLAGYD DFNCNVWDA LKADRAGVL AGHDNRVSC 
LGVTDDGMA VATGSWDSF LKIWN


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainA
ProteinG Protein α Sub unit
UniProtP63096
Sequence
>7YU5_Chain_A
SAEDKAAVE RSKMIDRNL REDGEKAAR EVKLLLLGA GESGKSTIV 
KQMKTGIVE THFTFKDLH FKMFDVGGQ RSERKKWIH CFEGVTAII 
FCVALSDYD LVLAEDEEM NRMHESMKL FDSICNNKW FTDTSIILF 
LNKKDLFEE KIKKSPLTI CYPEYAGSN TYEEAAAYI QCQFEDLNK 
RKDTKEIYT HFTCATDTK NVQFVFDAV TDVIIKNNL KDCGLF


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainG
ProteinG Protein γ Sub unit
UniProtP63212
Sequence
>7YU5_Chain_G
SIAQARKLV EQLKMEANI DRIKVSKAA ADLMAYCEA HAKEDPLLT 
PVPASENPF


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainR
ProteinReceptor
UniProtQ92633
Sequence
>7YU5_Chain_R
QCFYNESIA FFYNRSGKH LATEWNTVS KLVMGLGIT VCIFIMLAN 
LLVMVAIYV NRRFHFPIY YLMANLAAA DFFAGLAYF YLMFNTGPN 
TRRLTVSTW LLRQGLIDT SLTASVANL LAIAIERHI TVFRMQLHT 
RMSNRRVVV VIVVIWTMA IVMGAIPSV GWNCICDIE NCSNMAPLY 
SDSYLVFWA IFNLVTFVV MVVLYAHIF GYVRQRTMR MDTMMSLLK 
TVVIVLGAF IICWTPGLV LLLLDVCCP QCDVLAYEK FFLLLAEFN 
SAMNPIIYS YRDKEMSAT FR


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  




This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
4Z34ALipidLysophospholipid (LPA)LPA1Homo sapiensONO-9780307--32015-06-0310.1016/j.cell.2015.06.002
4Z35ALipidLysophospholipid (LPA)LPA1Homo sapiensONO-9910539--2.92015-06-0310.1016/j.cell.2015.06.002
4Z36ALipidLysophospholipid (LPA)LPA1Homo sapiensONO-3080573--2.92015-06-0310.1016/j.cell.2015.06.002
7TD0ALipidLysophospholipid (LPA)LPA1Homo sapiensLPA-Gi1/&β;1/&γ;22.832022-02-0910.1038/s41467-022-28417-2
7TD1ALipidLysophospholipid (LPA)LPA1Homo sapiensLPA-Gi1/&β;1/&γ;23.082022-02-0910.1038/s41467-022-28417-2
7TD2ALipidLysophospholipid (LPA)LPA1Homo sapiensLPA-Gi1/&β;1/&γ;23.112022-02-0910.1038/s41467-022-28417-2
7YU3ALipidLysophospholipid (LPA)LPA1Homo sapiensONO-0740556-Gi1/&β;1/&γ;23.52022-10-0510.1038/s41467-022-33121-2
7YU4ALipidLysophospholipid (LPA)LPA1Homo sapiensONO-0740556--3.72022-10-0510.1038/s41467-022-33121-2
7YU6ALipidLysophospholipid (LPA)LPA1Homo sapiensONO-0740556-Gi1/&β;1/&γ;23.92022-10-0510.1038/s41467-022-33121-2
7YU7ALipidLysophospholipid (LPA)LPA1Homo sapiensONO-0740556-Gi1/&β;1/&γ;24.52022-10-0510.1038/s41467-022-33121-2
7YU8ALipidLysophospholipid (LPA)LPA1Homo sapiensONO-0740556-Gi1/&β;1/&γ;25.62022-10-0510.1038/s41467-022-33121-2




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