Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg Int. Strength Num Of Links Community ConSurf
1B:B:L7 3.55408
2B:B:L14 3.775408
3B:B:T34 3.3525405
4B:B:V40 4.211676103
5B:B:L51 7.83489
6B:B:H54 6.72429789
7B:B:Y59 9.66518
8B:B:W63 6.94507
9B:B:V71 4.35478
10B:B:S74 4.8825489
11B:B:D76 6.35589
12B:B:L79 5.556577
13B:B:I80 7.4125488
14B:B:W82 8.90286789
15B:B:Y85 11.46494
16B:B:N88 4.065207
17B:B:K89 8.44333689
18B:B:I93 8.2025477
19B:B:L95 4.874578
20B:B:W99 8.30857719
21B:B:Y105 5.04406
22B:B:N110 7.2154174
23B:B:Y111 7.045174
24B:B:V112 4.0125478
25B:B:C114 4.2425478
26B:B:N119 4.1475419
27B:B:C121 3.7375418
28B:B:Y124 5.16776
29B:B:E130 4.9403
30B:B:V133 6.855474
31B:B:H142 8.308519
32B:B:Y145 5.79625818
33B:B:C149 3.84418
34B:B:F151 4.675609
35B:B:L152 3.45403
36B:B:I157 4.106517
37B:B:T159 4.69833619
38B:B:D163 9.375419
39B:B:W169 7.76429718
40B:B:F180 8.618567
41B:B:H183 8.125669
42B:B:D186 3.982519
43B:B:V187 4.2525469
44B:B:L190 5.495465
45B:B:F199 8.136569
46B:B:V200 8.4975456
47B:B:S201 5.5725469
48B:B:A203 4.6875468
49B:B:C204 5.945417
50B:B:D205 7.192569
51B:B:K209 9.616566
52B:B:L210 4.8825405
53B:B:W211 9.26667668
54B:B:Q220 8.0275457
55B:B:F222 8.61458
56B:B:H225 12.088559
57B:B:D228 8.85419
58B:B:I232 4.7075458
59B:B:F235 7.941437116
60B:B:P236 6.36254117
61B:B:N237 6.79754115
62B:B:F241 7.84333656
63B:B:T243 7.38458
64B:B:T249 5.8456
65B:B:R251 12.442558
66B:B:F253 7.68333656
67B:B:R256 6.615409
68B:B:D258 11.69457
69B:B:Q259 3.385406
70B:B:Y264 7.46333605
71B:B:F278 5.3456117
72B:B:R283 5.855109
73B:B:L284 4.774105
74B:B:L285 4.7475406
75B:B:Y289 8.876507
76B:B:N295 8.96254226
77B:B:K301 5.315405
78B:B:V307 3.934223
79B:B:H311 10.28254129
80B:B:V327 3.7975406
81B:B:T329 6.13408
82B:B:W332 15.7833619
83B:B:D333 9.8654129
84B:B:L336 3.932587
85B:B:K337 9.084126
86B:B:W339 10.6325129
87A:A:V34 5.41754235
88A:A:L37 4.9625409
89A:A:Q52 4.4425409
90A:A:I184 7.065419
91A:A:F191 8.76254155
92A:A:F196 7.9554237
93A:A:K197 7.95416
94A:A:F199 7.884515
95A:A:Q204 7.2225419
96A:A:S206 5.735418
97A:A:R208 4.3375419
98A:A:K210 7.08619
99A:A:W211 6.37857719
100A:A:H213 6.1775418
101A:A:F215 7.832519
102A:A:I222 3.885407
103A:A:V225 5.415407
104A:A:D229 6.5075448
105A:A:Y230 7.855648
106A:A:L232 7.7325448
107A:A:L234 6.2825408
108A:A:R242 10.1475449
109A:A:F250 6.576519
110A:A:N255 6.715408
111A:A:W258 7.09505
112A:A:F259 6.95254249
113A:A:L268 5.385408
114A:A:N269 5.7054149
115A:A:F274 5.045449
116A:A:K277 8.2725449
117A:A:I278 4.735446
118A:A:C286 4.274546
119A:A:Y287 6.76714747
120A:A:Y290 8.905407
121A:A:Y296 6.644504
122A:A:Y320 7.1456167
123A:A:T321 8.27415
124A:A:T324 5.71254149
125A:A:N331 6.834148
126A:A:F336 5.165158
127A:A:D341 10.84754168
128A:A:L353 4.49833637
129A:A:F354 5.0075435
130G:G:L19 3.4975409
131G:G:R27 5.4075408
132G:G:Y40 7.4954116
133G:G:D48 5.303336109
134G:G:L51 3.03406
135G:G:N59 6.582599
136G:G:P60 6.765499
137G:G:F61 5.08125898
138R:R:Y34 5.10167626
139R:R:I57 3.125404
140R:R:I63 4.1508
141R:R:N67 5.192509
142R:R:V70 3.56254139
143R:R:F80 9.423336138
144R:R:L91 5.128539
145R:R:D95 6.084509
146R:R:Y102 10.956507
147R:R:T109 3.6325425
148R:R:T113 4.36425
149R:R:L116 3.406526
150R:R:W121 8.43529
151R:R:R124 6.90286726
152R:R:Q125 10.015424
153R:R:D129 6.7675425
154R:R:L132 4.97427
155R:R:V136 5.5725428
156R:R:L139 5.0325438
157R:R:L140 4.7125407
158R:R:R146 6.166539
159R:R:H147 8.62754257
160R:R:F151 11.99754256
161R:R:R152 7.702535
162R:R:V164 3.7325407
163R:R:W172 4.5675409
164R:R:M178 4.145425
165R:R:I189 3.99403
166R:R:M198 7.8325183
167R:R:Y202 8.05167624
168R:R:Y206 8.9527
169R:R:W210 5.14526
170R:R:N214 9.2925427
171R:R:M221 2.525409
172R:R:Y225 5.72439
173R:R:Y231 8.8025406
174R:R:R235 5.98754157
175R:R:T236 4.145405
176R:R:M253 3.985407
177R:R:F267 10.08429
178R:R:W271 7.37375828
179R:R:P273 4.37409
180R:R:D281 7.6654184
181R:R:V282 4.165405
182R:R:V289 3.0185184
183R:R:Y311 5.19571739
184R:R:R314 8.752537
185R:R:M318 6.71754138
186L:L:?1 7.952141420
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
1B:B:W297 B:B:Y264 18.482615.43NoYes085
2B:B:W297 B:B:Y289 18.64545.79NoYes087
3B:B:I269 B:B:Y289 19.71736.04NoYes047
4B:B:D291 B:B:I269 20.15324.2NoNo084
5B:B:C271 B:B:D291 22.16046.22NoNo058
6B:B:C271 B:B:D290 22.59653.11NoNo056
7B:B:D290 B:B:R314 23.261622.63NoNo068
8B:B:R314 B:B:W332 23.479530.99NoYes089
9B:B:W332 B:B:Y59 53.35869.65YesYes198
10B:B:Q75 B:B:Y59 55.778814.65NoYes198
11B:B:Q75 B:B:W99 57.98414.38NoYes199
12B:B:L117 B:B:W99 34.06484.56NoYes199
13A:A:W211 B:B:L117 34.27593.42YesNo199
14A:A:W211 B:B:Y145 34.45566.75YesYes198
15B:B:G162 B:B:Y145 32.44978.69NoYes198
16B:B:G162 B:B:S161 32.39613.71NoNo199
17B:B:H142 B:B:S161 31.683415.34YesNo199
18B:B:H142 B:B:T159 26.07825.48YesYes199
19B:B:C149 B:B:T159 21.30493.38YesYes189
20B:B:C149 B:B:T102 21.40975.07YesNo088
21B:B:C148 B:B:T102 21.29283.38NoNo068
22B:B:C148 B:B:L190 21.17596.35NoYes065
23B:B:L190 B:B:S160 16.33597.51YesNo056
24B:B:S160 B:B:V187 16.0994.85NoYes069
25B:B:A203 B:B:V187 15.13353.39YesYes689
26B:B:A203 B:B:G202 14.53411.95YesNo086
27B:B:G202 B:B:I229 14.41413.53NoNo067
28A:A:F215 B:B:W99 34.089915.03YesYes199
29A:A:F215 A:A:W211 35.70434.01YesYes199
30B:B:S316 B:B:W332 29.43937.41NoYes099
31B:B:C317 B:B:S316 29.22113.44NoNo079
32B:B:C317 B:B:M61 29.0044.86NoNo076
33B:B:M61 B:B:W63 28.57313.49NoYes067
34B:B:T321 B:B:W63 16.050912.13NoYes077
35B:B:D323 B:B:T321 15.15817.23NoNo1977
36B:B:D323 B:B:M325 14.96085.54NoNo075
37B:B:M325 G:G:P49 15.15145.03NoNo057
38G:G:D48 G:G:P49 14.71124.83YesNo097
39A:A:D341 R:R:T236 96.21697.23YesYes085
40A:A:D341 R:R:M239 95.94546.93YesNo1687
41A:A:F334 R:R:M239 96.47643.73NoNo037
42A:A:F334 A:A:H322 96.563821.5NoNo039
43A:A:H322 A:A:N331 96.73876.38NoYes098
44A:A:N331 A:A:T324 96.70597.31YesYes1489
45A:A:N269 A:A:T324 98.87027.31YesYes1499
46A:A:C224 A:A:N269 99.57077.87NoYes079
47A:A:C224 A:A:S44 99.65673.44NoNo079
48A:A:A41 A:A:S44 99.82853.42NoNo079
49A:A:A41 A:A:E43 1003.02NoNo079
50A:A:D229 A:A:E43 49.96887.8YesNo489
51A:A:D229 A:A:L232 49.95524.07YesYes488
52A:A:D231 A:A:L232 50.15545.43NoYes498
53A:A:D231 A:A:Y230 50.13318.39NoYes498
54A:A:F274 A:A:Y230 97.99996.19YesYes498
55A:A:F274 A:A:L227 97.30556.09YesNo097
56A:A:L227 A:A:L268 97.71168.3NoYes078
57A:A:L268 A:A:T321 97.67832.95YesYes085
58A:A:L266 A:A:T321 97.45410.32NoYes195
59A:A:F223 A:A:L266 95.663.65NoNo199
60A:A:F223 A:A:L249 96.02196.09NoNo199
61A:A:L249 A:A:R208 95.84423.64NoYes199
62A:A:R208 A:A:W211 95.71856YesYes199
63A:A:E43 A:A:R242 50.116911.63NoYes499
64A:A:L232 A:A:R242 50.449915.79YesYes489
65A:A:K277 A:A:L232 50.25495.64YesYes498
66A:A:K277 A:A:Y230 50.24275.97YesYes498
67A:A:L348 A:A:L353 44.75614.15NoYes097
68A:A:L348 R:R:V232 44.97355.96NoNo097
69R:R:T236 R:R:V232 90.81513.17YesNo057
70A:A:L353 R:R:L256 44.75365.54YesNo077
71R:R:L256 R:R:V232 45.75914.47NoNo077
72A:A:L353 R:R:R146 85.12336.07YesYes379
73R:R:R146 R:R:Y311 61.78856.17YesYes399
74R:R:L139 R:R:Y311 37.98123.52YesYes389
75R:R:L139 R:R:N307 34.258.24YesNo089
76R:R:N303 R:R:N307 34.23336.81NoNo099
77R:R:N303 R:R:W271 33.56437.91NoYes098
78R:R:W210 R:R:W271 28.72644.69YesYes268
79L:L:?1 R:R:W210 25.56758.04YesYes206
80R:R:I142 R:R:R146 23.39033.76NoYes389
81R:R:I142 R:R:L91 23.17644.28NoYes389
82R:R:D95 R:R:L91 39.71935.43YesYes099
83R:R:D95 R:R:N67 26.78728.08YesYes099
84R:R:I63 R:R:V59 12.76163.07YesNo087
85R:R:L298 R:R:V59 11.86212.98NoNo067
86R:R:L298 R:R:Y102 10.06697.03NoYes067
87R:R:L91 R:R:Y311 23.1823.52YesYes399
88R:R:D95 R:R:S304 12.17645.89YesNo099
89R:R:A92 R:R:N67 13.80214.69NoYes099
90R:R:A92 R:R:V70 12.88353.39NoYes099
91R:R:M318 R:R:V70 11.0454.56YesYes1389
92R:R:F80 R:R:M318 10.126411.2YesYes1388
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


2D representation of the interactions of this orthosteric/allosteric ligand.


Links and nodes colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:K39 R:R:Y34 10.75 2 No Yes 8 6 1 1
R:R:T113 R:R:Y34 7.49 2 Yes Yes 5 6 1 1
R:R:P200 R:R:Y34 5.56 0 No Yes 6 6 2 1
L:L:?1 R:R:Y34 3.31 2 Yes Yes 0 6 0 1
L:L:?1 R:R:K39 8.96 2 Yes No 0 8 0 1
R:R:K294 R:R:V52 13.66 2 No No 4 5 1 2
R:R:M106 R:R:Y102 7.18 0 No Yes 6 7 2 2
R:R:L297 R:R:Y102 9.38 0 No Yes 6 7 1 2
R:R:L105 R:R:R124 6.07 0 No Yes 6 6 2 1
R:R:M106 R:R:T109 3.01 0 No Yes 6 5 2 1
R:R:N108 R:R:R124 8.44 0 No Yes 5 6 2 1
R:R:K294 R:R:T109 4.5 2 No Yes 4 5 1 1
L:L:?1 R:R:T109 5.2 2 Yes Yes 0 5 0 1
R:R:L116 R:R:T113 2.95 2 Yes Yes 6 5 2 1
R:R:R124 R:R:T113 3.88 2 Yes Yes 6 5 1 1
L:L:?1 R:R:T113 3.12 2 Yes Yes 0 5 0 1
R:R:L116 R:R:W121 3.42 2 Yes Yes 6 9 2 2
R:R:L116 R:R:R124 4.86 2 Yes Yes 6 6 2 1
R:R:R124 R:R:W121 8 2 Yes Yes 6 9 1 2
R:R:Q125 R:R:W121 16.43 2 Yes Yes 4 9 1 2
R:R:P200 R:R:W121 4.05 0 No Yes 6 9 2 2
R:R:Q125 R:R:R124 9.35 2 Yes Yes 4 6 1 1
L:L:?1 R:R:R124 7.72 2 Yes Yes 0 6 0 1
R:R:Q125 R:R:Y202 6.76 2 Yes Yes 4 4 1 1
L:L:?1 R:R:Q125 7.52 2 Yes Yes 0 4 0 1
R:R:D129 R:R:G126 5.03 2 Yes No 5 6 1 2
R:R:D129 R:R:Y202 9.2 2 Yes Yes 5 4 1 1
R:R:D129 R:R:Y206 8.05 2 Yes Yes 5 7 1 2
L:L:?1 R:R:D129 4.79 2 Yes Yes 0 5 0 1
R:R:L132 R:R:W210 3.42 2 Yes Yes 7 6 2 1
R:R:L132 R:R:W271 6.83 2 Yes Yes 7 8 2 2
R:R:M178 R:R:T133 4.52 2 Yes No 5 6 2 2
R:R:T133 R:R:W210 6.06 2 No Yes 6 6 2 1
R:R:M178 R:R:Y206 3.59 2 Yes Yes 5 7 2 2
R:R:M178 R:R:W210 3.49 2 Yes Yes 5 6 2 1
R:R:P182 R:R:Y202 11.13 2 No Yes 6 4 2 1
R:R:P182 R:R:Y206 18.08 2 No Yes 6 7 2 2
R:R:E293 R:R:M198 14.89 0 No Yes 4 3 1 2
R:R:A199 R:R:Y202 5.34 0 No Yes 4 4 2 1
R:R:Y202 R:R:Y206 10.92 2 Yes Yes 4 7 1 2
L:L:?1 R:R:Y202 4.96 2 Yes Yes 0 4 0 1
R:R:L207 R:R:L278 4.15 2 No No 6 6 1 1
R:R:L207 R:R:V282 2.98 2 No Yes 6 5 1 2
L:L:?1 R:R:L207 3.91 2 Yes No 0 6 0 1
R:R:W210 R:R:W271 4.69 2 Yes Yes 6 8 1 2
L:L:?1 R:R:W210 8.04 2 Yes Yes 0 6 0 1
L:L:?1 R:R:L278 6.84 2 Yes No 0 6 0 1
L:L:?1 R:R:E293 23.38 2 Yes No 0 4 0 1
L:L:?1 R:R:K294 6.97 2 Yes No 0 4 0 1
L:L:?1 R:R:L297 16.61 2 Yes No 0 6 0 1
R:R:L41 R:R:Y34 2.34 0 No Yes 2 6 2 1
R:R:G110 R:R:T109 1.82 0 No Yes 5 5 2 1
R:R:A211 R:R:L278 1.58 0 No No 4 6 2 1
R:R:N35 R:R:Y34 1.16 0 No Yes 7 6 2 1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

ShowSimilarityNetwork TypeNameLigandDescription
100.00Consensusgi_lpaOrthosteric Ligand7TD1-LPA1-LPA-Gi1/β1/γ2 7YU3-LPA1-ONO-0740556-Gi1/β1/γ2
100.00Consensuslpa_onOrthosteric Ligandlpa1_on
100.00Consensuslpa_on_gpOrthosteric Ligandlpa1_on_gp
92.31Single7YU3ONO-07405567YU3-LPA1-ONO-0740556-Gi1/β1/γ2
92.31Consensuslpa1_onOrthosteric Ligand7TD1-LPA1-LPA-Gi1/β1/γ2 7YU3-LPA1-ONO-0740556-Gi1/β1/γ2
92.31Consensuslpa1_on_gpOrthosteric Ligand7TD1-LPA1-LPA-Gi1/β1/γ2 7YU3-LPA1-ONO-0740556-Gi1/β1/γ2
86.67Single7YU8ONO-07405567YU8-LPA1-ONO-0740556-Gi1/β1/γ2
85.71Single7TD1LPA7TD1-LPA1-LPA-Gi1/β1/γ2
85.71Single7YU7ONO-07405567YU7-LPA1-ONO-0740556-Gi1/β1/γ2
85.71Single9IZGNKP9IZG-LPA1-NKP-chim(NtGi1-Gs-CtGq)/β1/γ2
84.62Single7YU4ONO-07405567YU4-LPA1-ONO-0740556
80.00Single9IZHLPA9IZH-LPA1-LPA-chim(NtGi2-G13)/β1/γ2
78.57Single7YU6ONO-07405567YU6-LPA1-ONO-0740556-Gi1/β1/γ2
75.00Single4Z35ONO-99105394Z35-LPA1-ONO-9910539
75.00Single9IZFNKP9IZF-LPA1-NKP-Gi1/β1/γ2
68.42Single7TD2LPA7TD2-LPA1-LPA-Gi1/β1/γ2
66.67Consensuslpl_onOrthosteric Ligands1p_on lpa_on
66.67Consensuslpl_on_gpOrthosteric Ligands1p_on_gp lpa_on_gp
62.50Single4Z34ONO-97803074Z34-LPA1-ONO-9780307
60.00Single7TD0LPA7TD0-LPA1-LPA-Gi1/β1/γ2
58.82Consensusgi_lipidOrthosteric Ligandgi_cannabinoid gi_ffa gi_leukotriene gi_lpa gi_s1p
58.82Consensuslpa1_offOrthosteric Ligand4Z36-LPA1-ONO-3080573 4Z35-LPA1-ONO-9910539 4Z34-LPA1-ONO-9780307
58.82Consensuslpa_offOrthosteric Ligandlpa1_off
55.00Single8F7SDeltorphin8F7S-δ-Deltorphin-Gi1/β1/γ2
55.00Consensusdop_on_gpOrthosteric Ligand8F7S-δ-Deltorphin-Gi1/β1/γ2
50.00Single4Z36ONO-30805734Z36-LPA1-ONO-3080573
50.00Single9J5VCpY9J5V-LPA1-CpY-Gi1/β1/γ2
50.00Consensuslipid_offonOrthosteric Ligandlipid_off lipid_on
50.00Consensuslipid_offon_gpOrthosteric Ligandlipid_on_gp lipid_off
50.00Consensuslpl_offOrthosteric Ligands1p_off lpa_off
47.62Single8F7WDynorphin8F7W-κ-Dynorphin-Gi1/β1/γ2
47.37Single8WRZPubChem 1023367048WRZ-CB1-PubChem 102336704-Arrestin2
47.06Consensuslipid_onOrthosteric Ligandcannabinoid_on ffa_on lpl_on prostanoid_on leukotriene_on
47.06Consensuslipid_on_gpOrthosteric Ligandcannabinoid_on_gp ffa_on_gp lpl_on_gp prostanoid_on_gp leukotriene_on_gp
46.67Single7WF7S1P7WF7-S1P1-S1P-Gi1/β1/γ2
45.83Consensusopioid_on_gpOrthosteric Ligandmop_on_gp nop_on_gp dop_on_gp kop_on_gp
45.00Single8F7REndomorphin8F7R-μ-Endomorphin-Gi1/β1/γ2
45.00Consensusdop_onOrthosteric Ligand8F7S-δ-Deltorphin-Gi1/β1/γ2
44.44Single8HQCC5a anaphylatoxin8HQC-C5a1-C5a anaphylatoxin-Go/β1/γ2
43.48Single8XWQEndothelin-18XWQ-ETB-Endothelin-1-Gi1/β1/γ2
42.86Single7TD4Siponimod7TD4-S1P1-Siponimod-Gi1/β1/γ2
42.11Single7EW2Fingolimod7EW2-S1P3-Fingolimod-Gi1/β1/γ2
42.11Single8I9AEP548I9A-C3aB-EP54-chim(NtGi1-Gs-CtGq)/β1/γ2
41.67Single7P02Protachykinin-17P02-NK1-Protachykinin-1-chim(NtGi1-Gs)/β1/γ2
41.67Single7Y64C5a anaphylatoxin7Y64-C5a1-C5a anaphylatoxin-Gi1/β1/γ2
41.67Single8ZRTET-18ZRT-ETB-ET-1
41.67Consensusopioid_onOrthosteric Ligandmop_on nop_on dop_on kop_on
41.18Single7YK7DC5910537YK7-RXFP4-DC591053-Gi2/β1/γ2
40.91Single8F7QBeta-Endorphin8F7Q-μ-β-Endorphin-Gi1/β1/γ2
40.91Consensuss1p3_on_gpOrthosteric Ligand7EW3-S1P3-S1P-Gi1/β1/γ2 7EW4-S1P3-CYM5541-Gi1/β1/γ2 7EW2-S1P3-Fingolimod-Gi1/β1/γ2
40.00Single3VGAZM-2413853VGA-A2A-ZM-241385-Antibody
40.00Single6DDFDamgo6DDF-μ-Damgo-Gi1/β1/γ2
40.00Single7EW0Ozanimod7EW0-S1P1-Ozanimod-Gi1/β1/γ2
40.00Single8GUTLEI-1028GUT-CB2-LEI-102-Gi1/β1/γ2
40.00Single8I95EP548I95-C3aB-EP54-Go/β1/γ2
40.00Single8IYSTUG-8918IYS-FFA4-TUG-891-GDP-chim(NtGi1L-Gq)/β1/γ2
38.89Single5NM2ZM-2413855NM2-A2A-ZM-241385-Na
38.89Single7SBFPZM217SBF-μ-PZM21-Gi1/β1/γ2
38.89Single7TD3S1P7TD3-S1P1-S1P-Gi1/β1/γ2
38.89Single8DZQmomSalB8DZQ-κ-momSalB-Go/β1/γ2
38.89Single8WGBW9R8WGB-mGlu4; mGlu2-Glutammate-W9R-Gi3/β1/γ2
38.89Consensuss1p_offOrthosteric Ligands1p1_off s1p5_off
38.46Single8FEG(DNCP)-Beta-Naloxamine8FEG-κ-(DNCP)-β-Naloxamine-Gi1/β1/γ2
38.46Single8XWPEndothelin-18XWP-ETB-Endothelin-1-Gi1/β1/γ2
38.46Single8ZH8QRF-Amide8ZH8-QRFP-QRF-Amide-Gq/β1/γ1
38.10Single7XBXCX3CL17XBX-CX3CR1-CX3CL1-Gi1/β1/γ2
38.10Single7XY6BAY 60-65837XY6-A2B-BAY 60-6583-chim(NtGi1-Gs)/β1/γ2
38.10Single7Y1FDynorphin7Y1F-κ-Dynorphin-Gi1/β1/γ2
38.10Single8H4IDoconexent8H4I-FFA4-Doconexent-chim(NtGi1-Gs)/β1/γ2
38.10Single8QJ2pN1628QJ2-MC4-pN162-Gs
38.10Single8X3LXWD8X3L-CB2-XWD-Gi1/β1/γ2
37.93Single6LRYSarafotoxin-B6LRY-ETB-Sarafotoxin-B
37.50Single3PWHZM-2413853PWH-A2A-ZM-241385
37.50Single7TUZ7-alpha,25-dihydroxycholesterol7TUZ-GPR183-7-α,25-dihydroxycholesterol-Gi1/β1/γ2
37.50Single7VDLCortistatin-147VDL-MRGPRX2-Cortistatin-14-Gi1/β1/γ2
37.50Single8H4KGW95088H4K-FFA4-GW9508-chim(NtGi1-Gs-CtGq)/β1/γ2
37.50Consensusc5a1_on_gpOrthosteric Ligand8HK5-C5a1-Complement C5-Gi1/β1/γ2 7Y66-C5a1-BM213-Gi1/β1/γ2 7Y67-C5a1-C089 peptide-Gi1/β1/γ2 7Y64-C5a1-C5a anaphylatoxin-Gi1/β1/γ2
37.50Consensusgi_class-aOrthosteric Ligandgi_peptide gi_sensory gi_alicarboxylic gi_amine gi_lipid gi_nucleotide gi_protein
37.04Single8IY5Endothelin-18IY5-ETB-Endothelin-1-Gi1/β1/γ2
37.04Consensusendothelin_onOrthosteric Ligandetb_on eta_on
36.84Single3P0GBI1671073P0G-β2-BI167107
36.84Single3SN6BI1671073SN6-β2-BI167107-Gs/β1/γ2
36.84Single5XRAAM115425XRA-CB1-AM11542
36.84Single6DDEDamgo6DDE-μ-Damgo-Gi1/β1/γ2
36.84Single7F58THIQ7F58-MC4-THIQ-Gs/β1/γ2
36.84Single7FEECP559407FEE-CB1-CP55940-ZCZ011
36.84Single7JVPSKF839597JVP-D1-SKF83959-Gs/β1/γ2
36.84Single7VIGCBP-3077VIG-S1P1-CBP-307-Gi1/β1/γ2
36.84Single8DCSCyanopindolol8DCS-β1-Cyanopindolol-Gs/β1/γ2
36.84Single8E0GBU728E0G-μ-BU72
36.84Single8I9LC3a anaphylatoxin8I9L-C3aB-C3a anaphylatoxin-Go/β1/γ2
36.84Single8ID39-Hydroxystearic acid8ID3-FFA4-9-Hydroxystearic acid-Gi1/β1/γ2
36.84Single8ID6Oleic acid8ID6-FFA4-Oleic acid-Gi1/β1/γ2
36.84Single8WU1PubChem 1190256658WU1-CB1-PubChem 119025665-Arrestin2
36.84Single8XBIS3E-LysoPS8XBI-GPR34-S3E-LysoPS
36.84Single9B65KCA9B65-CB1-KCA-Gi1/β1/γ2
36.84Single9GE2ML1849GE2-GPR55-ML184-Cholesterol-chim(CtGi1-G13)/β1/γ2
36.36Single7F4ISHU91197F4I-MC1-SHU9119-chim(NtGi1-Gs)/β1/γ2
36.36Single7W0PElabela7W0P-Apelin-Elabela-Gi1/β1/γ2
36.36Single8GHVAMG3158GHV-CB1-AMG315-Gi1/β1/γ2
36.36Single8XBHS3E-LysoPS8XBH-GPR34-S3E-LysoPS-Gi1/β1/γ2
36.36Consensusclass-a_on_gpOrthosteric Ligandsensory_on_gp alicarboxylic_on_gp amine_on_gp lipid_on_gp nucleotide_on_gp peptide_on_gp protein_on_gp
36.36Consensusgi_opioidOrthosteric Ligand8F7R-μ-Endomorphin-Gi1/β1/γ2 8EF5-μ-Fentanyl-Gi1/β1/γ2 7SCG-μ-FH210-Gi1/β1/γ2 7T2H-μ-Lofentanil-Gi1/β1/γ2 7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2 8DZP-κ-momSalB-Gi1/β1/γ2 8EF6-μ-Morphine-Gi1/β1/γ2 8F7X-NOP-Nociceptin-Gi1/β1/γ2 8EFB-μ-Oliceridine-Gi1/β1/γ2 7U2L-μ-PubChem 163201242-Gi1/β1/γ2 8EFO-μ-PZM21-Gi1/β1/γ2 8EFL-μ-SR17018-Gi1/β1/γ2 8F7Q-μ-β-Endorphin-Gi1/β1/γ2 7U2K-μ-C6-guano-Gi1/β1/γ2 8EFQ-μ-Damgo-Gi1/β1/γ2 8F7S-δ-Deltorphin-Gi1/β1/γ2 8F7W-κ-Dynorphin-Gi1/β1/γ2
36.00Single7F6HBradykinin7F6H-BK2-Bradykinin-Gq/β1/γ2
36.00Single8XVHEndothelin-18XVH-ETB-Endothelin-1-chim(Gs-CtGq)/β1/γ2
35.71Single5GLHEndothelin-15GLH-ETB-Endothelin-1
35.71Single6IGKEndothelin-36IGK-ETB-Endothelin-3
35.29Single3V2YPubChem 518926453V2Y-S1P1-PubChem 51892645
35.29Single5IU4ZM-2413855IU4-A2A-ZM-241385-Na
35.29Single5IUBQ274563445IUB-A2A-Q27456344-Na
35.29Single5K2CZM-2413855K2C-A2A-ZM-241385-Na
35.29Single5NM4ZM-2413855NM4-A2A-ZM-241385-Na
35.29Single6AQFZM-2413856AQF-A2A-ZM-241385
35.29Single6PT0WIN 55212-26PT0-CB2-WIN 55212-2-Gi1/β1/γ2
35.29Single7AROLUF58337ARO-A2A-LUF5833-Na
35.29Single7SR8TAK-9257SR8-OX2-TAK-925-chim(NtGi1L-Gs-CtGq)/β1/γ2
35.29Single7YK6PubChem 1383196747YK6-RXFP4-PubChem 138319674-Gi2/β1/γ2
35.29Single8GUQOlorinab8GUQ-CB2-Olorinab-Gi1/β1/γ2
35.29Single8GURCP55,9408GUR-CB2-CP55,940-Gi1/β1/γ2
35.29Single8K9KDamgo8K9K-μ-Damgo-Gi3/β1/γ1
35.29Single8K9LDamgo8K9L-μ-Damgo-VV9-Gi3/β1/γ1
35.29Consensusadenosine_onOrthosteric Liganda1_on a2_on a3_on
35.29Consensusgi_adenosineOrthosteric Ligand7LD4-A1-Adenosine-Gi2/β1/γ2 8X17-A3A-Namodenoson-Gi1/β1/γ2 8X16-A3A-Piclidenoson-Gi1/β1/γ2
35.00Single2YCXCyanopindolol2YCX-β1-Cyanopindolol
35.00Single4LDEBI1671074LDE-β2-BI167107
35.00Single4PXZ2MeSADP4PXZ-P2Y12-2MeSADP
35.00Single4RWADIPP-NH24RWA-δ-DIPP-NH2
35.00Single5F8UCyanopindolol5F8U-β1-Cyanopindolol
35.00Single6KPGAM8416KPG-CB1-AM841-Gi1/β1/γ2
35.00Single6KQICP559406KQI-CB1-CP55940-Org27569
35.00Single6OS0Angiotensinogen6OS0-AT1-Angiotensinogen
35.00Single7YITNalfurafine7YIT-κ-Nalfurafine
35.00Single8IA8E7 peptide8IA8-C3aB-E7 peptide-Gi1/β1/γ2
35.00Single8JJ8Formoterol8JJ8-β2-Formoterol
35.00Single8JJLOlodaterol8JJL-β2-Olodaterol
35.00Single8JPBNeurotensin-(8-13)8JPB-NTS1-Neurotensin-(8-13)-PubChem 118610427; GDP; Mg-Gq; GRK2
35.00Single9GYOP3959GYO-GPBA-P395-chim(NtGi1-Gs)/β1/γ2
35.00Consensuskop_onOrthosteric Ligand8F7W-κ-Dynorphin-Gi1/β1/γ2 8DZS-κ-GR89,696-chim(NtGi2-Gz)/β1/γ2 8DZP-κ-momSalB-Gi1/β1/γ2
35.00Consensusopioid_offOrthosteric Ligandmop_off nop_off dop_off kop_off
35.00Consensuss1p3_onOrthosteric Ligand7EW3-S1P3-S1P-Gi1/β1/γ2 7EW4-S1P3-CYM5541-Gi1/β1/γ2 7EW2-S1P3-Fingolimod-Gi1/β1/γ2
34.78Single7DDZJNJ-310200287DDZ-Y2-JNJ-31020028
34.78Single7RMISubstance-P7RMI-NK1-Substance-P-chim(Gs-CtGq)/β1/γ2
34.78Consensusccr8_on_gpOrthosteric Ligand8KFX-CCR8-LMD-009-Gi1/β1/γ2 8KFY-CCR8-ZK-756326-Gi1/β1/γ2 8U1U-CCR8-CCL1-Gi1/β1/γ2
34.78Consensuscompl-peptide_onOrthosteric Ligandc5a1_on c3a_on
34.78Consensusgi_ghrelinOrthosteric Ligand7NA7-Ghrelin-Ghrelin-27-Gi1/β1/γ2 7NA8-Ghrelin-PubChem 178024-Gi1/β1/γ2
34.78Consensusnpy2_offOrthosteric Ligand7DDZ-Y2-JNJ-31020028
34.78Consensussst4_onOrthosteric Ligand7XMS-SST4-Somatostatin-14-Gi1/β1/γ2 7XMT-SST4-J-2156-Gi1/β1/γ2
34.78Consensussst4_on_gpOrthosteric Ligand7XMS-SST4-Somatostatin-14-Gi1/β1/γ2 7XMT-SST4-J-2156-Gi1/β1/γ2
34.62Single8XQFApelin-138XQF-Apelin-Apelin-13-Gi1/β1/γ2
34.62Consensusgi_compl-peptOrthosteric Ligand8HK5-C5a1-Complement C5-Gi1/β1/γ2 8IA8-C3aB-E7 peptide-Gi1/β1/γ2 7Y66-C5a1-BM213-Gi1/β1/γ2 7Y67-C5a1-C089 peptide-Gi1/β1/γ2 8HK2-C3aB-C3a anaphylatoxin-Gi1/β1/γ2 7Y64-C5a1-C5a anaphylatoxin-Gi1/β1/γ2
34.62Consensusgi_peptideOrthosteric Ligandgi_cck gi_apelin gi_compl-pept gi_endothelin gi_formylpeptide gi_galanin gi_ghrelin gi_npy gi_neurotensin gi_opioid gi_orexin gi_relaxin gi_somatostatin
34.48Single8HBDIRL16208HBD-ETB-IRL1620-Gi1/β1/γ2
34.48Consensusendothelin_on_gpOrthosteric Ligandetb_on_gp eta_on_gp
34.48Consensusmelanocortin_onOrthosteric Ligandmc1_on mc4_on mc2_on mc3_on mc5_on
34.48Consensusmelanocortin_on_gpOrthosteric Ligandmc1_on_gp mc4_on_gp mc2_on_gp mc3_on_gp mc5_on_gp
33.33Single3OE0CVX153OE0-CXCR4-CVX15
33.33Single4EIYZM-2413854EIY-A2A-ZM-241385-Na
33.33Single4QIMANTA XV4QIM-SMO-ANTA XV
33.33Single4RWSvMIP-II4RWS-CXCR4-vMIP-II
33.33Single5IU8Q274563475IU8-A2A-Q27456347-Na
33.33Single5OLGZM-2413855OLG-A2A-ZM-241385-Na
33.33Single5UENDU1725UEN-A1-DU172
33.33Single5UIGCmpd-15UIG-A2A-Cmpd-1
33.33Single6LPJZM-2413856LPJ-A2A-ZM-241385-Na
33.33Single6LPKZM-2413856LPK-A2A-ZM-241385-Na
33.33Single6LW5WKYMVm6LW5-FPR2-ALX-WKYMVm
33.33Single6XBM25(S)-Epoxycholesterol6XBM-SMO-25(S)-Epoxycholesterol-Gi1/β1/γ2
33.33Single6Z4VNTS8-136Z4V-NTS1-NTS8-13
33.33Single7BU7BI1671077BU7-β1-BI167107
33.33Single7CRHSKF839597CRH-D1-SKF83959-Gs/β1/γ2
33.33Single7EVZCenerimod7EVZ-S1P1-Cenerimod-Gi1/β1/γ2
33.33Single7F4FAfamelanotide7F4F-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2
33.33Single7F53Alpha-MSH7F53-MC4-α-MSH-Gs/β1/γ2
33.33Single7MBXCholecystokinin-87MBX-CCKA-Cholecystokinin-8-Gs/β1/γ1
33.33Single7O7F6P4-CCL57O7F-CCR5-6P4-CCL5-Gi1/β1/γ1
33.33Single7P00Substance-P7P00-NK1-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
33.33Single7PYRPSB-21157PYR-A2A-PSB-2115
33.33Single7V3ZCP559407V3Z-CB1-CP55940
33.33Single7X2DTavapadon7X2D-D1-Tavapadon-Gs/β1/γ2
33.33Single7XJISolabegron7XJI-β3-Solabegron-Gs/β1/γ2
33.33Single7XK2MK68927XK2-HCA2-MK6892-Gi1/β1/γ2
33.33Single8GAGPubChem 1708384908GAG-CB1-PubChem 170838490-Gi1/β1/γ2
33.33Single8IC0Interleukin-88IC0-CXCR1-Interleukin-8-Gi1/β1/γ2
33.33Single8IJDMK68928IJD-HCA2-MK6892-Gi1/β1/γ2
33.33Single8J21Butyric acid8J21-FFA3-Butyric acid-Gi1/β1/γ2
33.33Single8J24Acetic acid8J24-FFA2-Acetic acid-Gi1/β1/γ2
33.33Single8JPFNeurotensin8JPF-NTS1-Neurotensin-PubChem 118610427
33.33Single8RW7StilSwitch18RW7-A2A-StilSwitch1-Na
33.33Single8WKZSBL-MC-318WKZ-MC4-SBL-MC-31
33.33Single8X17Namodenoson8X17-A3A-Namodenoson-Gi1/β1/γ2
33.33Single8XBES3E-LysoPS8XBE-GPR34-S3E-LysoPS-Gi1/β1/γ1
33.33Single8XIQL7967788XIQ-SST3-L796778-chim(NtGi1-Gs-CtGi1)/β1/γ2
33.33Single8XIRPasireotide8XIR-SST3-Pasireotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
33.33Single9B54A1AIW9B54-CB1-A1AIW-Gi1/β1/γ2
33.33Single9GE3Lysophosphatidylinositol9GE3-GPR55-Lysophosphatidylinositol-chim(CtGi1-G13)/β1/γ2
33.33Consensusa3_onOrthosteric Liganda3a_on
33.33Consensusadenosine_on_gpOrthosteric Liganda1_on_gp a2_on_gp a3_on_gp
33.33Consensusangiotensin_onOrthosteric Ligandat1_on
33.33Consensusat1_onOrthosteric Ligand7F6G-AT1-SAR1-AngII-Gq/β1/γ2
33.33Consensusc5a1_onOrthosteric Ligand8HK5-C5a1-Complement C5-Gi1/β1/γ2 7Y66-C5a1-BM213-Gi1/β1/γ2 7Y67-C5a1-C089 peptide-Gi1/β1/γ2 7Y64-C5a1-C5a anaphylatoxin-Gi1/β1/γ2
33.33Consensuscb1_on_gpOrthosteric Ligand6KPG-CB1-AM841-Gi1/β1/γ2 8K8J-CB1-Fenofibrate-chim(Gs-CtGq)/β1/γ2
33.33Consensusclass-a_onOrthosteric Ligandsensory_on alicarboxylic_on amine_on lipid_on nucleotide_on peptide_on protein_on
33.33Consensuscompl-peptide_on_gpOrthosteric Ligandc5a1_on_gp c3a_on_gp
33.33Consensuscxcr1_on_gpOrthosteric Ligand8IC0-CXCR1-Interleukin-8-Gi1/β1/γ2
33.33Consensusffa3_onOrthosteric Ligand8J21-FFA3-Butyric acid-Gi1/β1/γ2
33.33Consensusffa3_on_gpOrthosteric Ligand8J21-FFA3-Butyric acid-Gi1/β1/γ2
33.33Consensusgi_s1pOrthosteric Ligand7VIE-S1P1-S1P-Gi1/β1/γ2 7EW3-S1P3-S1P-Gi1/β1/γ2 7EVY-S1P1-Siponimod-Gi1/β1/γ2 7EW1-S1P5-Siponimod-Gi1/β1/γ2 7VIF-S1P1-S-FTY720-P-Gi1/β1/γ2 7VIG-S1P1-CBP-307-Gi1/β1/γ2 7EVZ-S1P1-Cenerimod-Gi1/β1/γ2 7EW4-S1P3-CYM5541-Gi1/β1/γ2 7EW2-S1P3-Fingolimod-Gi1/β1/γ2 7EW0-S1P1-Ozanimod-Gi1/β1/γ2 7EW7-S1P1-SEW2871-Gi1/β1/γ2
33.33Consensusgq_peptideOrthosteric Ligandgq_cck gq_kisspeptin gq_bradykinin gq_bombesin gq_angiotensin
33.33Consensusgs_class-aOrthosteric Ligandgs_peptide gs_nucleotide gs_amine
33.33Consensuskop_on_gpOrthosteric Ligand8F7W-κ-Dynorphin-Gi1/β1/γ2 8DZS-κ-GR89,696-chim(NtGi2-Gz)/β1/γ2 8DZP-κ-momSalB-Gi1/β1/γ2
33.33Consensuslipid_offOrthosteric Ligandcannabinoid_off paf_off lpl_off prostanoid_off leukotriene_off
33.33Consensusnk1_onOrthosteric Ligand7P00-NK1-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
33.33Consensusnk1_on_gpOrthosteric Ligand7P00-NK1-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
33.33Consensusnucleotide_offonOrthosteric Ligandnucleotide_off nucleotide_on
33.33Consensusnucleotide_offon_gpOrthosteric Ligandnucleotide_on_gp nucleotide_off
33.33Consensusnucleotide_on_gpOrthosteric Ligandadenosine_on_gp p2y_on_gp
33.33Consensuspeptide_offonOrthosteric Ligandpeptide_off peptide_on
33.33Consensuspeptide_onOrthosteric Ligandcck_on angiotensin_on apelin_on bombesin_on bradykinin_on compl-peptide_on endothelin_on formylpeptide_on galanin_on ghrelin_on kisspeptin_on melanocortin_on motilin_on neuromedin-u_on npy_on neurotensin_on opioid_on orexin_on relaxin_on somatostatin_on tachykinin_on trh_on vasop-oxy_on
33.33Consensuspeptide_on_gpOrthosteric Ligandcck_on_gp angiotensin_on_gp apelin_on_gp bombesin_on_gp bradykinin_on_gp compl-peptide_on_gp endothelin_on_gp formylpeptide_on_gp galanin_on_gp ghrelin_on_gp kisspeptin_on_gp melanocortin_on_gp motilin_on_gp neuromedin-u_on_gp npy_on_gp neurotensin_on_gp opioid_on_gp orexin_on_gp relaxin_on_gp somatostatin_on_gp tachykinin_on_gp trh_on_gp vasop-oxy_on_gp
32.14Single6IGLIRL16206IGL-ETB-IRL1620
32.14Single8IY6Endothelin-18IY6-ETB-Endothelin-1
32.14Consensusbk2_onOrthosteric Ligand7F6H-BK2-Bradykinin-Gq/β1/γ2 7F6I-BK2-Kallidin-Gq/β1/γ2
32.14Consensusbk2_on_gpOrthosteric Ligand7F6H-BK2-Bradykinin-Gq/β1/γ2 7F6I-BK2-Kallidin-Gq/β1/γ2
32.14Consensusbradykinin_onOrthosteric Ligandbk2_on
32.14Consensusbradykinin_on_gpOrthosteric Ligandbk2_on_gp
32.14Consensusgq_bradykininOrthosteric Ligand7F6H-BK2-Bradykinin-Gq/β1/γ2 7F6I-BK2-Kallidin-Gq/β1/γ2
32.14Consensusgs_melanocortinOrthosteric Ligand7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2 7F54-MC4-Afamelanotide-Gs/β1/γ2 7F4D-MC1-α-MSH-chim(NtGi1-Gs)/β1/γ2 8INR-MC5-α-MSH-Ca-chim(NtGi1-Gs)/β1/γ2 7F53-MC4-α-MSH-Gs/β1/γ2 7F55-MC4-Bremelanotide-Gs/β1/γ2 8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1 8IOC-MC3-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2 8IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/β1/γ2 7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2 7F4I-MC1-SHU9119-chim(NtGi1-Gs)/β1/γ2 7F58-MC4-THIQ-Gs/β1/γ2
32.00Single7F6GSAR1-AngII7F6G-AT1-SAR1-AngII-Gq/β1/γ2
32.00Single8IHFMK68928IHF-HCA2-MK6892-Gi1/β1/γ2
32.00Single8XZJWN3538XZJ-Apelin-WN353-Gi1/β1/γ2
32.00Single9BKKCholecystokinin-89BKK-CCKA-Cholecystokinin-8-chim(NtGi1-Gs-CtGq)/β1/γ2
32.00Consensusangiotensin_on_gpOrthosteric Ligandat1_on_gp
32.00Consensusat1_on_gpOrthosteric Ligand7F6G-AT1-SAR1-AngII-Gq/β1/γ2
32.00Consensusgq_angiotensinOrthosteric Ligand7F6G-AT1-SAR1-AngII-Gq/β1/γ2
32.00Consensuspeptide_offon_gpOrthosteric Ligandpeptide_on_gp peptide_off
31.82Single3NY9ICI118-5513NY9-β2-ICI118-551
31.82Single6C1QPMX536C1Q-C5a1-PMX53-NDT9513727
31.82Single7RKFFractalkine7RKF-US28-Fractalkine-GDP-chim(NtGi1-G11)/β1/γ2
31.82Single7RKNFractalkine7RKN-US28-Fractalkine-Gi1/β1/γ2
31.82Single7RMGSubstance-P7RMG-NK1-Substance-P-chim(Gs-CtGq)/β1/γ2
31.82Single7RMHSubstance-P7RMH-NK1-Substance-P-Gs/β1/γ2
31.82Single7YJ4INSL57YJ4-RXFP4-INSL5-Gi2/β1/γ2
31.82Single8JBFSenktide8JBF-NK3-Senktide-chim(NtGi1-Gs-CtGq)/β1/γ2
31.82Single9ERXD9-THC analog9ERX-CB1-D9-THC analog-Gi1/β1/γ2
31.82Consensuss1p_onOrthosteric Ligands1p1_on s1p3_on s1p5_on
31.82Consensuss1p_on_gpOrthosteric Ligands1p1_on_gp s1p3_on_gp s1p5_on_gp
31.58Single4RWDDIPP-NH24RWD-δ-DIPP-NH2-Na
31.58Single5C1MBU725C1M-μ-BU72
31.58Single5IUAQ274563485IUA-A2A-Q27456348-Na
31.58Single6E67BI1671076E67-β2-BI167107-Gs (fused)
31.58Single6LPLZM-2413856LPL-A2A-ZM-241385-Na
31.58Single6S0QZM-2413856S0Q-A2A-ZM-241385
31.58Single6W2XPubChem 237279706W2X-GABAB1, GABAB2-PubChem 5311042-PubChem 23727970
31.58Single6WQAZM-2413856WQA-A2A-ZM-241385-Na
31.58Single6XBKCholesterol6XBK-SMO-Cholesterol-Gi1/β1/γ2
31.58Single7C4SS1P7C4S-S1P3-S1P
31.58Single7CFNINT-7777CFN-GPBA-INT-777-Gs/β1/γ2
31.58Single7CKXA776367CKX-D1-A77636-Gs/β1/γ2
31.58Single7EO2FTY720-P7EO2-S1P1-FTY720-P-Gi1/β1/γ2
31.58Single7EPFNAM5977EPF-mGlu2; mGlu2-NAM597
31.58Single7LD3Adenosine7LD3-A1-Adenosine-PubChem 25263603-Gi2/β1/γ2
31.58Single7RM5ZM-2413857RM5-A2A-ZM-241385-Na
31.58Single7WC6LSD7WC6-5-HT2A-LSD
31.58Single8FYNZM-2413858FYN-A2A-ZM-241385-Na
31.58Single8ID4Linoleic acid8ID4-FFA4-Linoleic acid-Gi1/β1/γ2
31.58Single8J6JGSK2560738J6J-HCA2-GSK256073-Gi1/β1/γ2
31.58Single8JXSPF-61428JXS-D1-PF-6142
31.58Single8SZGCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-chim(NtGi1-Gq)/β1/γ2
31.58Single8TF5Oleic acid8TF5-GPR6-Oleic acid
31.58Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/β1/γ2
31.58Consensusa1_offOrthosteric Ligand5UEN-A1-DU172 5N2S-A1-PSB36
31.58Consensusa3_on_gpOrthosteric Liganda3a_on_gp
31.58Consensusa3a_onOrthosteric Ligand8X17-A3A-Namodenoson-Gi1/β1/γ2 8X16-A3A-Piclidenoson-Gi1/β1/γ2
31.58Consensusa3a_on_gpOrthosteric Ligand8X17-A3A-Namodenoson-Gi1/β1/γ2 8X16-A3A-Piclidenoson-Gi1/β1/γ2
31.58Consensusadenosine_offOrthosteric Liganda1_off a2_off
31.58Consensuscb2_onOrthosteric Ligand8GUR-CB2-CP55,940-Gi1/β1/γ2 8GUS-CB2-HU-308-Gi1/β1/γ2 8GUT-CB2-LEI-102-Gi1/β1/γ2 6KPF-CB2-PubChem 145915889-Gi1/β1/γ2 6PT0-CB2-WIN 55212-2-Gi1/β1/γ2 8GUQ-CB2-Olorinab-Gi1/β1/γ2
31.58Consensuscb2_on_gpOrthosteric Ligand8GUR-CB2-CP55,940-Gi1/β1/γ2 8GUS-CB2-HU-308-Gi1/β1/γ2 8GUT-CB2-LEI-102-Gi1/β1/γ2 6KPF-CB2-PubChem 145915889-Gi1/β1/γ2 6PT0-CB2-WIN 55212-2-Gi1/β1/γ2 8GUQ-CB2-Olorinab-Gi1/β1/γ2
31.58Consensusd1_onOrthosteric Ligand7F0T-D1-Dopamine-Gs/β1/γ2 7CKY-D1-PW0464-Gs/β1/γ2 8IRR-D1-Rotigotine-Gs/β1/γ2 7JV5-D1-SKF81297-Gs/β1/γ2 7JVP-D1-SKF83959-Gs/β1/γ2 7X2D-D1-Tavapadon-Gs/β1/γ2 7CKX-D1-A77636-Gs/β1/γ2 7JVQ-D1-Apomorphine-Gs/β1/γ2 7CKW-D1-Fenoldopam-Gs/β1/γ2
31.58Consensusnucleotide_onOrthosteric Ligandadenosine_on p2y_on
31.58Consensusrxfp4_onOrthosteric Ligand7YK7-RXFP4-DC591053-Gi2/β1/γ2 7YJ4-RXFP4-INSL5-Gi2/β1/γ2 7YK6-RXFP4-PubChem 138319674-Gi2/β1/γ2
31.58Consensusrxfp4_on_gpOrthosteric Ligand7YK7-RXFP4-DC591053-Gi2/β1/γ2 7YJ4-RXFP4-INSL5-Gi2/β1/γ2 7YK6-RXFP4-PubChem 138319674-Gi2/β1/γ2
31.58Consensuss1p5_offOrthosteric Ligand7YXA-S1P5-ONO-5430608
31.25Single6LI0C176LI0-GPR52-C17
31.25Single6QNOAll-trans-Retinal6QNO-Rhodopsin-All-trans-Retinal-Gi1/β1/γ1
31.25Single8RWHStilSwitch28RWH-A2A-StilSwitch2-Na
31.03Single8U1UCCL18U1U-CCR8-CCL1-Gi1/β1/γ2
31.03Consensusccr5_on_gpOrthosteric Ligand7O7F-CCR5-6P4-CCL5-Gi1/β1/γ1 7F1Q-CCR5-MIP-1a-Gi1/β1/γ2
31.03Consensusgi_endothelinOrthosteric Ligand8IY5-ETB-Endothelin-1-Gi1/β1/γ2 8HBD-ETB-IRL1620-Gi1/β1/γ2
30.77Single7F6IKallidin7F6I-BK2-Kallidin-Gq/β1/γ2
30.77Single8HCQEndothelin-18HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/β1/γ2
30.77Single8HCXEndothelin-18HCX-ETB-Endothelin-1-chim(NtGi2L-Gs-CtGq)/β1/γ2
30.77Single8HK5Complement C58HK5-C5a1-Complement C5-Gi1/β1/γ2
30.77Single8IA2C5a anaphylatoxin8IA2-C5a1-C5a anaphylatoxin-Go/β1/γ2
30.77Single8XVIEndothelin-18XVI-ETA-Endothelin-1-chim(Gs-CtGq)/β1/γ2
30.77Single8ZPSPrRP208ZPS-PrRP-PrRP20-chim(NtGi1-Gs-CtGq)/β1/γ2
30.77Consensuseta_onOrthosteric Ligand8HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/β1/γ2
30.77Consensuseta_on_gpOrthosteric Ligand8HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/β1/γ2
30.43Single4IB4Ergotamine4IB4-5-HT2B-Ergotamine
30.43Single7F54Afamelanotide7F54-MC4-Afamelanotide-Gs/β1/γ2
30.43Single7L0RNeurotensin7L0R-NTS1-Neurotensin-Gi1/β1/γ1
30.43Single7NA7Ghrelin-277NA7-Ghrelin-Ghrelin-27-Gi1/β1/γ2
30.43Single7W2ZGhrelin7W2Z-Ghrelin-Ghrelin-Go/β1/γ2
30.43Single8F7XNociceptin8F7X-NOP-Nociceptin-Gi1/β1/γ2
30.43Single8G59TUG-8918G59-FFA4-TUG-891-chim(Gi1-CtGq)/β1/γ2
30.43Single8J6RMK68928J6R-HCA2-MK6892-Gi1/β1/γ2
30.43Single8K3ZCXCL128K3Z-CXCR4-CXCL12-Gi1/β1/γ1
30.43Single8WDTphotoNECA8WDT-A2A-photoNECA
30.43Consensusgi_nucleotideOrthosteric Ligandgi_adenosine gi_p2y
30.43Consensusmc4_onOrthosteric Ligand7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2 7F58-MC4-THIQ-Gs/β1/γ2 7F54-MC4-Afamelanotide-Gs/β1/γ2 7F53-MC4-α-MSH-Gs/β1/γ2 7F55-MC4-Bremelanotide-Gs/β1/γ2
30.43Consensusmop_offOrthosteric Ligand4DKL-μ-β-Funaltrexamine 8QOT-μ-Nanobody-E 7UL4-μ-Alvimopan
30.43Consensusnk3_onOrthosteric Ligand8JBF-NK3-Senktide-chim(NtGi1-Gs-CtGq)/β1/γ2
30.43Consensusnk3_on_gpOrthosteric Ligand8JBF-NK3-Senktide-chim(NtGi1-Gs-CtGq)/β1/γ2
30.43Consensusp2y_onOrthosteric Ligandp2y1_on p2y10_on p2y12_on
30.00Single3PDSHydroxybenzylisoproterenol3PDS-β2-Hydroxybenzylisoproterenol
30.00Single3ZEVNeurotensin3ZEV-NTS1-Neurotensin
30.00Single4BV0Neurotensin4BV0-NTS1-Neurotensin
30.00Single4DJHJDTic4DJH-κ-JDTic
30.00Single4LDLHydroxybenzylisoproterenol4LDL-β2-Hydroxybenzylisoproterenol
30.00Single5V56TC1145V56-SMO-TC114
30.00Single5XR8AM8415XR8-CB1-AM841
30.00Single6GT3Imaradenant6GT3-A2A-Imaradenant-Na
30.00Single6H7JIsoprenaline6H7J-β1-Isoprenaline
30.00Single6N48BI1671076N48-β2-BI167107-PubChem 138454256
30.00Single6NI3BI1671076NI3-β2-BI167107-Gs/β1/γ2
30.00Single6OS1TRV0266OS1-AT1-TRV026
30.00Single7CKYPW04647CKY-D1-PW0464-Gs/β1/γ2
30.00Single7EW1Siponimod7EW1-S1P5-Siponimod-Gi1/β1/γ2
30.00Single7EW3S1P7EW3-S1P3-S1P-Gi1/β1/γ2
30.00Single7JJOIsoprenaline7JJO-β1-Isoprenaline-Gs/β1/γ2
30.00Single7JV5SKF812977JV5-D1-SKF81297-Gs/β1/γ2
30.00Single7L0PNeurotensin7L0P-NTS1-Neurotensin-Gi1/β1/γ1
30.00Single7L0QNeurotensin7L0Q-NTS1-Neurotensin-Gi1/β1/γ1
30.00Single7M8W15r-Methyl-Prostaglandin D27M8W-DP2-15r-Methyl-Prostaglandin D2-Na
30.00Single7PX4PSB-21137PX4-A2A-PSB-2113
30.00Single7SK6CXCL12_LRHQ7SK6-ACKR3-CXCL12_LRHQ
30.00Single7TUYGSK682753A7TUY-GPR183-GSK682753A
30.00Single7WV9CP559407WV9-CB1-CP55940-ZCZ011-Gi2/β1/γ2
30.00Single7XTQR3997XTQ-GPBA-R399-Gs/β1/γ2
30.00Single8DZPmomSalB8DZP-κ-momSalB-Gi1/β1/γ2
30.00Single8FMZNeurotensin/Neuromedin-N8FMZ-NTS1-Neurotensin/Neuromedin-N-chim(NtGi2L-Gs-CtGq)/β1/γ2
30.00Single8GUSHU-3088GUS-CB2-HU-308-Gi1/β1/γ2
30.00Single8HDOBAY 60-65838HDO-A2B-BAY 60-6583-Gs/β1/γ2
30.00Single8HPTC5a anaphylatoxin C-terminal peptide8HPT-C5a1-C5a anaphylatoxin C-terminal peptide-Go/β1/γ2
30.00Single8IHBGSK2560738IHB-HCA2-GSK256073-Gi1/β1/γ2
30.00Single8JSRAnamorelin8JSR-Ghrelin-Anamorelin-chim(NtGi1-Gs-CtGq)/β1/γ2
30.00Single8JZPC5A anaphylatoxin8JZP-C5a1-C5A anaphylatoxin-Go/β1/γ2
30.00Single8T1VPubChem 1183102098T1V-GPR6-PubChem 118310209-Na
30.00Single8UGWPubChem 30865998UGW-A2A-PubChem 3086599
30.00Single8VVFJDTic8VVF-κ-JDTic-Gi1/β1/γ2
30.00Single8X16Piclidenoson8X16-A3A-Piclidenoson-Gi1/β1/γ2
30.00Single8XVLZibotentan8XVL-ETA-Zibotentan
30.00Single8YH6Namodenoson8YH6-A3A-Namodenoson-Gi1/β1/γ2
30.00Single9IJDCarazolol9IJD-β3-Carazolol-chim(NtGi1-Gs)/β1/γ2
30.00Consensusa2_onOrthosteric Liganda2b_on
30.00Consensusa2_on_gpOrthosteric Liganda2b_on_gp
30.00Consensusa2b_onOrthosteric Ligand8HDP-A2B-Adenosine-Gs/β1/γ2 7XY6-A2B-BAY 60-6583-chim(NtGi1-Gs)/β1/γ2 7XY7-A2B-NECA-chim(NtGi1-Gs)/β1/γ2 8HDO-A2B-BAY 60-6583-Gs/β1/γ2
30.00Consensusa2b_on_gpOrthosteric Ligand8HDP-A2B-Adenosine-Gs/β1/γ2 7XY6-A2B-BAY 60-6583-chim(NtGi1-Gs)/β1/γ2 7XY7-A2B-NECA-chim(NtGi1-Gs)/β1/γ2 8HDO-A2B-BAY 60-6583-Gs/β1/γ2
30.00Consensusclass-a_offOrthosteric Ligandsensory_off alicarboxylic_off amine_off lipid_off nucleotide_off peptide_off protein_off
30.00Consensuscyslt1_offOrthosteric Ligand6RZ5-CysLT1-Zafirlukast-Na 6RZ4-CysLT1-Pranlukast-Na
30.00Consensusd1_on_gpOrthosteric Ligand7F0T-D1-Dopamine-Gs/β1/γ2 7CKY-D1-PW0464-Gs/β1/γ2 8IRR-D1-Rotigotine-Gs/β1/γ2 7JV5-D1-SKF81297-Gs/β1/γ2 7JVP-D1-SKF83959-Gs/β1/γ2 7X2D-D1-Tavapadon-Gs/β1/γ2 7CKX-D1-A77636-Gs/β1/γ2 7JVQ-D1-Apomorphine-Gs/β1/γ2 7CKW-D1-Fenoldopam-Gs/β1/γ2
30.00Consensusetb_on_gpOrthosteric Ligand8IY5-ETB-Endothelin-1-Gi1/β1/γ2 8HBD-ETB-IRL1620-Gi1/β1/γ2
30.00Consensusffa_onOrthosteric Ligandffa2_on ffa3_on
30.00Consensusffa_on_gpOrthosteric Ligandffa2_on_gp ffa3_on_gp
30.00Consensusgi_cannabinoidOrthosteric Ligand8GUR-CB2-CP55,940-Gi1/β1/γ2 8GUS-CB2-HU-308-Gi1/β1/γ2 8GUT-CB2-LEI-102-Gi1/β1/γ2 8GUQ-CB2-Olorinab-Gi1/β1/γ2 6KPF-CB2-PubChem 145915889-Gi1/β1/γ2 6PT0-CB2-WIN 55212-2-Gi1/β1/γ2 6KPG-CB1-AM841-Gi1/β1/γ2
30.00Consensusgi_ffaOrthosteric Ligand8J21-FFA3-Butyric acid-Gi1/β1/γ2 8J22-FFA2-TUG-1375-Gi1/β1/γ2
30.00Consensusgi_relaxinOrthosteric Ligand7YK7-RXFP4-DC591053-Gi2/β1/γ2 7YJ4-RXFP4-INSL5-Gi2/β1/γ2 7YK6-RXFP4-PubChem 138319674-Gi2/β1/γ2
30.00Consensusgs_adenosineOrthosteric Ligand8HDP-A2B-Adenosine-Gs/β1/γ2 8HDO-A2B-BAY 60-6583-Gs/β1/γ2 7XY7-A2B-NECA-chim(NtGi1-Gs)/β1/γ2 7XY6-A2B-BAY 60-6583-chim(NtGi1-Gs)/β1/γ2
30.00Consensusgs_dopamineOrthosteric Ligand7F0T-D1-Dopamine-Gs/β1/γ2 7CKW-D1-Fenoldopam-Gs/β1/γ2 7CKY-D1-PW0464-Gs/β1/γ2 8IRV-D5-Rotigotine-chim(NtGi1-Gs)/β1/γ2 8IRR-D1-Rotigotine-Gs/β1/γ2 7JV5-D1-SKF81297-Gs/β1/γ2 7JVP-D1-SKF83959-Gs/β1/γ2 7X2D-D1-Tavapadon-Gs/β1/γ2 7CKX-D1-A77636-Gs/β1/γ2 7JVQ-D1-Apomorphine-Gs/β1/γ2
30.00Consensusgs_nucleotideOrthosteric Ligandgs_adenosine
30.00Consensuskop_offOrthosteric Ligand4DJH-κ-JDTic
30.00Consensusmotilin_onOrthosteric Ligand8IBU-Motilin-Erythromycin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
30.00Consensusneurotensin_onOrthosteric Ligandnts1_on
30.00Consensusnts1_onOrthosteric Ligand6OSA-NTS1-JMV449-Gi1/β1/γ2 7L0S-NTS1-Neurotensin-Gi1/β1/γ1
30.00Consensusrelaxin_onOrthosteric Ligandrxfp4_on
30.00Consensusrelaxin_on_gpOrthosteric Ligandrxfp4_on_gp
30.00Consensuss1p5_onOrthosteric Ligand7EW1-S1P5-Siponimod-Gi1/β1/γ2
30.00Consensuss1p5_on_gpOrthosteric Ligand7EW1-S1P5-Siponimod-Gi1/β1/γ2
29.63Single4XT3Fractalkine4XT3-US28-Fractalkine
29.63Single5UIW5P7-CCL55UIW-CCR5-5P7-CCL5
29.63Single7SK4CXCL12_LRHQ7SK4-ACKR3-CXCL12_LRHQ
29.63Single8XVEBQ30208XVE-ETB-BQ3020-chim(Gs-CtGq)/β1/γ2
29.63Consensusccr5_offOrthosteric Ligand5UIW-CCR5-5P7-CCL5
29.41Single3V2WPubChem 518926453V2W-S1P1-PubChem 51892645
29.41Single5K2DZM-2413855K2D-A2A-ZM-241385-Na
29.41Single5OLHVipadenant5OLH-A2A-Vipadenant-Na
29.41Single6DS0Ly2660976DS0-5-HT2B-Ly266097
29.41Single6JZHZM-2413856JZH-A2A-ZM-241385-Na
29.41Single6PS7ZM-2413856PS7-A2A-ZM-241385-Na
29.41Single6TQ6PubChem 1457142836TQ6-OX1-PubChem 145714283
29.41Single8DU3PubChem 1055260648DU3-A2A-PubChem 105526064
29.41Single8EFOPZM218EFO-μ-PZM21-Gi1/β1/γ2
29.41Single8H8JLodoxamide8H8J-GPR35-Lodoxamide-Ca-chim(NtGi1L-G13)/β1/γ2
29.41Single8HMPC178HMP-GPR52-C17-Gs/β1/γ2
29.41Single8J20Valeric acid8J20-FFA3-Valeric acid-AR420626-Gi1/β1/γ2
29.41Single8RVWStilSwitch38RVW-A2A-StilSwitch3-Na
29.41Single8RW0Istradefylline8RW0-A2A-Istradefylline-Na
29.41Single8RW4AzoSwitch28RW4-A2A-AzoSwitch2-Na
29.41Single8RWEStilSwitch48RWE-A2A-StilSwitch4-Na
29.41Single8T3SButyric acid8T3S-FFA2-Butyric acid-chim(NtGi2L-Gs-CtGq)/β1/γ2
29.41Single9FUPIstradefylline9FUP-A2A-Istradefylline-Na
29.41Consensuscxcr1_onOrthosteric Ligand8IC0-CXCR1-Interleukin-8-Gi1/β1/γ2
29.41Consensuss1p1_offOrthosteric Ligand3V2W-S1P1-PubChem 51892645
29.17Single3QAKUK-4320973QAK-A2A-UK-432097
29.17Single6DO1Angiotensin-like peptide S1I86DO1-AT1-Angiotensin-like peptide S1I8
29.17Single7C6A(Sar1,Ile8)-Angiotensin II7C6A-AT2-(Sar1,Ile8)-Angiotensin II
29.17Single7CUMPhospholipid7CUM-GABAB1, GABAB2-CGP54626-Phospholipid
29.17Single7PIVSetmelanotide7PIV-MC4-Setmelanotide-Gs/β1/γ2
29.17Single7RKMFractalkine7RKM-US28-Fractalkine-Gi1/β1/γ2
29.17Single7XMSSomatostatin-147XMS-SST4-Somatostatin-14-Gi1/β1/γ2
29.17Single8IBVMotilin8IBV-Motilin-Motilin-chim(NtGi1-Gs-CtGq)/β1/γ2
29.17Single9EAINanobody AT2099EAI-AT1-Losartan-Nanobody AT209
29.17Consensusmc4_on_gpOrthosteric Ligand7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2 7F58-MC4-THIQ-Gs/β1/γ2 7F54-MC4-Afamelanotide-Gs/β1/γ2 7F53-MC4-α-MSH-Gs/β1/γ2 7F55-MC4-Bremelanotide-Gs/β1/γ2
29.17Consensustachykinin_on_gpOrthosteric Ligandnk1_on_gp nk2_on_gp nk3_on_gp
29.03Consensusgs_peptideOrthosteric Ligandgs_cck gs_melanocortin gs_vasop-oxy
28.57Single4GRVNeurotensin-(8-13)4GRV-NTS1-Neurotensin-(8-13)
28.57Single4PY02MeSATP4PY0-P2Y12-2MeSATP
28.57Single4XEENeurotensin4XEE-NTS1-Neurotensin
28.57Single4XESNeurotensin4XES-NTS1-Neurotensin
28.57Single5TZYMK8666; PubChem 1270535975TZY-FFA1-MK8666; PubChem 127053597
28.57Single6MXTSalmeterol6MXT-β2-Salmeterol
28.57Single6OS2TRV0266OS2-AT1-TRV026
28.57Single6OSAJMV4496OSA-NTS1-JMV449-Gi1/β1/γ2
28.57Single7BZ2Arformoterol7BZ2-β2-Arformoterol-Gs/β1/γ2
28.57Single7DH5Mirabegron7DH5-β3-Mirabegron-Gs/β1/γ2
28.57Single7EO4BAF3127EO4-S1P1-BAF312-Gi1/β1/γ2
28.57Single7EVYSiponimod7EVY-S1P1-Siponimod-Gi1/β1/γ2
28.57Single7L0SNeurotensin7L0S-NTS1-Neurotensin-Gi1/β1/γ1
28.57Single7L1VPubChem 1554910097L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/β1/γ2
28.57Single7T6BS1P7T6B-S1P2-S1P-chim(NtGi1L-G13)/β1/γ2
28.57Single7W0NElabela7W0N-Apelin-Elabela-Gi1/β1/γ2
28.57Single7XATSomatostatin-147XAT-SST2-Somatostatin-14-Gi1/β1/γ2
28.57Single8HK2C3a anaphylatoxin8HK2-C3aB-C3a anaphylatoxin-Gi1/β1/γ2
28.57Single8IBUErythromycin-A8IBU-Motilin-Erythromycin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
28.57Single8ID9Eicosapentaenoic acid8ID9-FFA4-Eicosapentaenoic acid-Gi1/β1/γ2
28.57Single8JWY2-1188JWY-A2A-2-118
28.57Single8U26Protachykinin-18U26-NK1-Protachykinin-1-Gs/β1/γ2
28.57Single8W1VPubChem 1717162658W1V-β2-PubChem 171716265
28.57Single8WRBLysophosphatidylserine8WRB-GPR34-Lysophosphatidylserine-Gi1/β1/γ2
28.57Single8ZPLHF511168ZPL-CXCR4-HF51116-Cholesterol
28.57Single9L3WRetinoic acid receptor responder protein 29L3W-CML1-Retinoic acid receptor responder protein 2-Gi1/β1/γ2
28.57Consensusbeta3_onOrthosteric Ligand7DH5-β3-Mirabegron-Gs/β1/γ2 7XJH-β3-Isoproterenol-Gs/β1/γ2 7XJI-β3-Solabegron-Gs/β1/γ2
28.57Consensusbeta3_on_gpOrthosteric Ligand7DH5-β3-Mirabegron-Gs/β1/γ2 7XJH-β3-Isoproterenol-Gs/β1/γ2 7XJI-β3-Solabegron-Gs/β1/γ2
28.57Consensusbeta_onOrthosteric Ligandbeta1_on beta2_on beta3_on
28.57Consensusbeta_on_gpOrthosteric Ligandbeta1_on_gp beta2_on_gp beta3_on_gp
28.57Consensuscannabinoid_offOrthosteric Ligandcb2_off cb1_off
28.57Consensuscannabinoid_onOrthosteric Ligandcb2_on cb1_on
28.57Consensuscannabinoid_on_gpOrthosteric Ligandcb2_on_gp cb1_on_gp
28.57Consensuscb1_onOrthosteric Ligand6KPG-CB1-AM841-Gi1/β1/γ2 8K8J-CB1-Fenofibrate-chim(Gs-CtGq)/β1/γ2
28.57Consensusccr8_onOrthosteric Ligand8KFX-CCR8-LMD-009-Gi1/β1/γ2 8KFY-CCR8-ZK-756326-Gi1/β1/γ2 8U1U-CCR8-CCL1-Gi1/β1/γ2
28.57Consensusgi_neurotensinOrthosteric Ligand6OSA-NTS1-JMV449-Gi1/β1/γ2 7L0S-NTS1-Neurotensin-Gi1/β1/γ1
28.57Consensusleukotriene_offOrthosteric Ligandblt_off cyslt_off
28.57Consensusmop_onOrthosteric Ligand8F7R-μ-Endomorphin-Gi1/β1/γ2 8EF5-μ-Fentanyl-Gi1/β1/γ2 7SCG-μ-FH210-Gi1/β1/γ2 7T2H-μ-Lofentanil-Gi1/β1/γ2 7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2 8EF6-μ-Morphine-Gi1/β1/γ2 8EFB-μ-Oliceridine-Gi1/β1/γ2 7U2L-μ-PubChem 163201242-Gi1/β1/γ2 8EFO-μ-PZM21-Gi1/β1/γ2 8EFL-μ-SR17018-Gi1/β1/γ2 8F7Q-μ-β-Endorphin-Gi1/β1/γ2 7U2K-μ-C6-guano-Gi1/β1/γ2 8EFQ-μ-Damgo-Gi1/β1/γ2
28.57Consensusmop_on_gpOrthosteric Ligand8F7R-μ-Endomorphin-Gi1/β1/γ2 8EF5-μ-Fentanyl-Gi1/β1/γ2 7SCG-μ-FH210-Gi1/β1/γ2 7T2H-μ-Lofentanil-Gi1/β1/γ2 7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2 8EF6-μ-Morphine-Gi1/β1/γ2 8EFB-μ-Oliceridine-Gi1/β1/γ2 7U2L-μ-PubChem 163201242-Gi1/β1/γ2 8EFO-μ-PZM21-Gi1/β1/γ2 8EFL-μ-SR17018-Gi1/β1/γ2 8F7Q-μ-β-Endorphin-Gi1/β1/γ2 7U2K-μ-C6-guano-Gi1/β1/γ2 8EFQ-μ-Damgo-Gi1/β1/γ2
28.57Consensusmotilin_on_gpOrthosteric Ligand8IBU-Motilin-Erythromycin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
28.57Consensusneurotensin_on_gpOrthosteric Ligandnts1_on_gp
28.57Consensusnts1_on_gpOrthosteric Ligand6OSA-NTS1-JMV449-Gi1/β1/γ2 7L0S-NTS1-Neurotensin-Gi1/β1/γ1
28.57Consensuss1p1_onOrthosteric Ligand7VIE-S1P1-S1P-Gi1/β1/γ2 7VIF-S1P1-S-FTY720-P-Gi1/β1/γ2 7VIG-S1P1-CBP-307-Gi1/β1/γ2 7EVY-S1P1-Siponimod-Gi1/β1/γ2 7EVZ-S1P1-Cenerimod-Gi1/β1/γ2 7EW0-S1P1-Ozanimod-Gi1/β1/γ2 7EW7-S1P1-SEW2871-Gi1/β1/γ2
28.57Consensuss1p1_on_gpOrthosteric Ligand7VIE-S1P1-S1P-Gi1/β1/γ2 7VIF-S1P1-S-FTY720-P-Gi1/β1/γ2 7VIG-S1P1-CBP-307-Gi1/β1/γ2 7EVY-S1P1-Siponimod-Gi1/β1/γ2 7EVZ-S1P1-Cenerimod-Gi1/β1/γ2 7EW0-S1P1-Ozanimod-Gi1/β1/γ2 7EW7-S1P1-SEW2871-Gi1/β1/γ2
28.12Single7X9ANeuropeptide-Y7X9A-Y1-Neuropeptide-Y-Gi1/β1/γ2
28.00Single6PT2KGCHM076PT2-δ-KGCHM07
28.00Single7XOUCholecystokinin-87XOU-CCKA-Cholecystokinin-8-Gs/β1/γ2
28.00Single8K6MNeuropeptide-Y8K6M-Y1-Neuropeptide-Y-Gi2/β1/γ1
28.00Consensuscxcr4_on_gpOrthosteric Ligand8K3Z-CXCR4-CXCL12-Gi1/β1/γ1
28.00Consensusgs_cckOrthosteric Ligand7MBX-CCKA-Cholecystokinin-8-Gs/β1/γ1
28.00Consensusnpy1_onOrthosteric Ligand8K6M-Y1-Neuropeptide-Y-Gi2/β1/γ1
28.00Consensusnpy1_on_gpOrthosteric Ligand8K6M-Y1-Neuropeptide-Y-Gi2/β1/γ1
27.78Single3REYXAC3REY-A2A-XAC
27.78Single4DKLBeta-Funaltrexamine4DKL-μ-β-Funaltrexamine
27.78Single5IU7Q274563465IU7-A2A-Q27456346-Na
27.78Single5JTBZM-2413855JTB-A2A-ZM-241385
27.78Single5NLXZM-2413855NLX-A2A-ZM-241385-Na
27.78Single6FK8PubChem 1324730356FK8-Rhodopsin-PubChem 132473035
27.78Single6MH8ZM-2413856MH8-A2A-ZM-241385
27.78Single6VI4JDTic6VI4-κ-JDTic
27.78Single6ZDRHMS1413f126ZDR-A2A-HMS1413f12-Na
27.78Single7C2EPubChem 1490507997C2E-GLP-1-PubChem 149050799-Gs/β1/γ2
27.78Single7T32ZM-2413857T32-A2A-ZM-241385
27.78Single8K4NVF08K4N-GPR34-VF0-Gi1/β1/γ2
27.78Single8K4SDCA-3P8K4S-MRGPRX4-DCA-3P-chim(NtGi1L-Gs-CtGq)/β1/γ2
27.78Single8RQQZM-2413858RQQ-A2A-ZM-241385-Na
27.78Single8RWCStilSwitch28RWC-A2A-StilSwitch2-Na
27.78Single8RWDStilSwitch38RWD-A2A-StilSwitch3-Na
27.78Single8RWIStilSwitch28RWI-A2A-StilSwitch2-Na
27.78Single8UO0Constrained Epinephrine8UO0-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
27.78Single8Y45ADL58598Y45-δ-ADL5859-Gi2/β1/γ2
27.78Single8Y62C16:0 Ceramide8Y62-FPR2-ALX-C16:0 Ceramide-Gi1/β1/γ2
27.78Single8YH2Adenosine8YH2-A3A-Adenosine-Gi1/β1/γ2
27.78Single8YKVPubChem 1375531688YKV-Succinate-PubChem 137553168-Gi1/β1/γ2
27.78Single9K1DButanoic acid9K1D-FFA2-Butanoic acid-Cholesterol-Gi1/β1/γ2
27.78Consensusa2_offOrthosteric Liganda2a_off
27.78Consensusa2a_offOrthosteric Ligand3RFM-A2A-Caffeine 8C9W-A2A-Etrumadenant 3UZA-A2A-GTPL9236 8GNG-A2A-Istradefylline 8CU6-A2A-LJ-4517 7PX4-A2A-PSB-2113 7PYR-A2A-PSB-2115 8DU3-A2A-PubChem 105526064 8JWY-A2A-2-118 8PWN-A2A-Theophylline 5IU4-A2A-ZM-241385-Na 5OLZ-A2A-PubChem 135566609-Na 6GT3-A2A-Imaradenant-Na 5OLV-A2A-LUAA41063-Na 5N2R-A2A-PSB-36-Na 5IU7-A2A-Q27456346-Na 5OLH-A2A-Vipadenant-Na 5OLO-A2A-Tozadenant-Na 6ZDR-A2A-HMS1413f12-Na 8GNE-A2A-KW-6356-Na 8JWZ-A2A-AB928-Na 5IU8-A2A-Q27456347-Na 5IUB-A2A-Q27456344-Na 6ZDV-A2A-Chromone 5d-Na 5IUA-A2A-Q27456348-Na 8A2P-A2A-LUAA47070-Na
27.78Consensusnucleotide_offOrthosteric Ligandadenosine_off p2y_off
27.59Consensusetb_onOrthosteric Ligand8IY5-ETB-Endothelin-1-Gi1/β1/γ2 8HBD-ETB-IRL1620-Gi1/β1/γ2
27.27Single2YCZIodocyanopindolol2YCZ-β1-Iodocyanopindolol
27.27Single4BUONeurotensin4BUO-NTS1-Neurotensin
27.27Single5TUDErgotamine5TUD-5-HT2B-Ergotamine
27.27Single5X93K-87945X93-ETB-K-8794
27.27Single6BQGErgotamine6BQG-5-HT2C-Ergotamine
27.27Single6H7LDobutamine6H7L-β1-Dobutamine
27.27Single6IBLArformoterol6IBL-β1-Arformoterol
27.27Single6TKOArformoterol6TKO-β1-Arformoterol-Arrestin2
27.27Single6UP7Neurotensin6UP7-NTS1-Neurotensin-Arrestin2
27.27Single7EZCUKA7EZC-A2A-UKA
27.27Single7JVRBromoergocryptine7JVR-D2-Bromoergocryptine-Gi1/β1/γ2
27.27Single7MTSADX551647MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/β1/γ2
27.27Single7Y65C5a peptide7Y65-C5a1-C5a peptide-Gi1/β1/γ2
27.27Single8ID8TUG-8918ID8-FFA4-TUG-891-Gi1/β1/γ2
27.27Single8K4OCXCL18K4O-KSHV-CXCL1-Gi1/β1/γ1
27.27Single8XGSMetastin8XGS-Kiss1-Metastin-chim(NtGi1-Gq)/β1/γ2
27.27Single8ZX4Lysophosphatidylinositol 8ZX4-GPR55-Lysophosphatidylinositol-chim(NtGi1-G13)/β1/γ2
27.27Consensusbeta1_onOrthosteric Ligand8DCR-β1-Dobutamine-Gs/β1/γ2 7S0F-β1-Isoprenaline-Gi1/β1/γ2
27.27Consensusbeta1_on_gpOrthosteric Ligand8DCR-β1-Dobutamine-Gs/β1/γ2 7S0F-β1-Isoprenaline-Gi1/β1/γ2
27.27Consensusc3a_on_gpOrthosteric Ligand8HK2-C3aB-C3a anaphylatoxin-Gi1/β1/γ2 8IA8-C3aB-E7 peptide-Gi1/β1/γ2
27.27Consensuspeptide_offOrthosteric Ligandcck_off angiotensin_off bombesin_off endothelin_off ghrelin_off npy_off opioid_off orexin_off somatostatin_off tachykinin_off vasop-oxy_off neurotensin_off
26.92Single5WB2CX3CL1.355WB2-US28-CX3CL1.35
26.92Single6JODAngiotensin II6JOD-AT2-Angiotensin II
26.92Single6WI9Secretin6WI9-Secretin-Secretin-Gs/β1/γ2
26.92Single7DW9AVP7DW9-V2-AVP-chim(NtGi1-Gs)/β1/γ2
26.92Single7KH0AVP7KH0-V2-AVP-chim(NtGi1-Gs)/β1/γ2
26.92Single7T10Somatostatin-147T10-SST2-Somatostatin-14-Gi3/β1/γ2
26.92Single7W40Bombesin7W40-BB2-Bombesin-chim(NtGi1L-Gq)/β1/γ2
26.92Single7YONPeptide-YY(3-36)7YON-Y2-Peptide-YY(3-36)-Gi1/β1/γ2
26.92Single8J6IMK68928J6I-HCA2-MK6892-Gi1/β1/γ2
26.92Single8X8LCortistatin8X8L-SST5-Cortistatin-chim(NtGi1-Gs-CtGi1)/β1/γ2
26.92Consensuscxcr3_on_gpOrthosteric Ligand8HNK-CXCR3-CXCL11-Gi1/β1/γ2 8HNL-CXCR3-PS372424-Gi1/β1/γ2
26.92Consensusgi_formylpeptideOrthosteric Ligand7WVY-FPR2-ALX-Amyloid-β42-Gi2/β1/γ2 7T6U-FPR2-ALX-CGEN-855A-Gi1/β1/γ2 7VFX-FPR1-ALX-fMLF-Gi1/β1/γ2 7T6V-FPR2-ALX-fMLFII-Gi1/β1/γ2 7WVX-FPR2-ALX-Humanin-Gi2/β1/γ2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/β1/γ2 6OMM-FPR2-ALX-WKYMVX-Gi1/β1/γ2
26.92Consensusgs_vasop-oxyOrthosteric Ligand7DW9-V2-AVP-chim(NtGi1-Gs)/β1/γ2
26.92Consensusp2y_on_gpOrthosteric Ligandp2y1_on_gp p2y10_on_gp p2y12_on_gp
26.92Consensusprotein_offonOrthosteric Ligandprotein_off protein_on
26.92Consensusprotein_offon_gpOrthosteric Ligandprotein_on_gp protein_off
26.92Consensusprotein_onOrthosteric Ligandchemokine_on chemerin_on
26.92Consensustachykinin_onOrthosteric Ligandnk1_on nk2_on nk3_on
26.92Consensusv2_onOrthosteric Ligand7DW9-V2-AVP-chim(NtGi1-Gs)/β1/γ2
26.92Consensusv2_on_gpOrthosteric Ligand7DW9-V2-AVP-chim(NtGi1-Gs)/β1/γ2
26.92Consensusvasop-oxy_onOrthosteric Ligandv2_on
26.92Consensusvasop-oxy_on_gpOrthosteric Ligandv2_on_gp
26.67Single3RFMCaffeine3RFM-A2A-Caffeine
26.67Single6OT025(S)-Epoxycholesterol6OT0-SMO-25(S)-Epoxycholesterol-Gi1/β1/γ2
26.67Single8A2OTheophylline8A2O-A2A-Theophylline-Na
26.47Consensusmc2_onOrthosteric Ligand8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1
26.47Consensusmc2_on_gpOrthosteric Ligand8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1
26.32Single2Y01Dobutamine2Y01-β1-Dobutamine
26.32Single2Y02Carmoterol2Y02-β1-Carmoterol
26.32Single2Y04Salbutamol2Y04-β1-Salbutamol
26.32Single2YCYCyanopindolol2YCY-β1-Cyanopindolol
26.32Single3EMLZM-2413853EML-A2A-ZM-241385
26.32Single4EJ4Naltrindole4EJ4-δ-Naltrindole
26.32Single5K2AZM-2413855K2A-A2A-ZM-241385-Na
26.32Single5VRAZM-2413855VRA-A2A-ZM-241385-Na
26.32Single5ZKPForopafant (SR27417)5ZKP-PAF-Foropafant (SR27417)
26.32Single6FK7PubChem 1324730346FK7-Rhodopsin-PubChem 132473034
26.32Single6FKCPubChem 1324730396FKC-Rhodopsin-PubChem 132473039
26.32Single6KPFPubChem 1459158896KPF-CB2-PubChem 145915889-Gi1/β1/γ2
26.32Single6PRZS-Alprenolol6PRZ-β2-S-Alprenolol
26.32Single6S0LZM-2413856S0L-A2A-ZM-241385
26.32Single7JOZVFP7JOZ-D1-VFP-Gs/β1/γ2
26.32Single7JVQApomorphine7JVQ-D1-Apomorphine-Gs/β1/γ2
26.32Single7LCKDanuglipron7LCK-GLP-1-Danuglipron
26.32Single7LJCSKF-812977LJC-D1-SKF-81297-Mevidalen-Gs/β1/γ2
26.32Single7PP1Selatogrel7PP1-P2Y12-Selatogrel
26.32Single7S0GIsoprenaline7S0G-β1-Isoprenaline-chim(Gi1-CtGs)/β1/γ2
26.32Single7S15PubChem 1346112237S15-GLP-1-PubChem 134611223
26.32Single7SQOTAK-9257SQO-OX2-TAK-925-Gi1/β1/γ2
26.32Single7UL4Alvimopan7UL4-μ-Alvimopan
26.32Single7UM6Lisuride7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/β1/γ2
26.32Single7VIES1P7VIE-S1P1-S1P-Gi1/β1/γ2
26.32Single7VIFS-FTY720-P7VIF-S1P1-S-FTY720-P-Gi1/β1/γ2
26.32Single7XJHIsoproterenol7XJH-β3-Isoproterenol-Gs/β1/γ2
26.32Single7YXAONO-54306087YXA-S1P5-ONO-5430608
26.32Single8CU6LJ-45178CU6-A2A-LJ-4517
26.32Single8CU7LJ-45178CU7-A2A-LJ-4517-Na
26.32Single8EFQDamgo8EFQ-μ-Damgo-Gi1/β1/γ2
26.32Single8EJKTAK-8758EJK-FFA1-TAK-875-chim(NtGi1L-Gs-CtGq)/β1/γ2
26.32Single8I7VAcipimox8I7V-HCA2-Acipimox-Gi1/β1/γ2
26.32Single8IHJAcifran8IHJ-HCA3-Acifran-Gi1/β1/γ2
26.32Single8JXRLSD8JXR-D1-LSD
26.32Single8RLNLUF58348RLN-A2A-LUF5834
26.32Single8RWXStilSwitch38RWX-A2A-StilSwitch3-Na
26.32Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/β1/γ2
26.32Single8UNVConstrained Epinephrine8UNV-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
26.32Single8UNZConstrained Epinephrine8UNZ-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
26.32Single8UO2Constrained Epinephrine8UO2-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
26.32Single8XBGS3E-LysoPS8XBG-GPR34-S3E-LysoPS
26.32Single8XVKAmbrisentan8XVK-ETA-Ambrisentan
26.32Single9AVGCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVG-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs)/β1/γ2
26.32Single9CHXS-Carazolol9CHX-β2-S-Carazolol
26.32Single9D61JDTic9D61-κ-JDTic-Gi1/β1/γ2
26.32Single9IYAONO-97105319IYA-GPR55-ONO-9710531
26.32Consensus5ht5_onOrthosteric Ligand5ht5a_on
26.32Consensus5ht5a_onOrthosteric Ligand7X5H-5-HT5A-5-CT-Gi1/β1/γ2 7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/β1/γ2 7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/β1/γ2
26.32Consensusdop_offOrthosteric Ligand4EJ4-δ-Naltrindole
26.32Consensusgi_orexinOrthosteric Ligand7SQO-OX2-TAK-925-Gi1/β1/γ2
26.09Single4UG2CGS216804UG2-A2A-CGS21680
26.09Single5VBLApelin mimetic peptide agonist5VBL-Apelin-Apelin mimetic peptide agonist
26.09Single5WF6UK-4320975WF6-A2A-UK-432097
26.09Single5ZTYAM102575ZTY-CB2-AM10257
26.09Single6G79Donitriptan6G79-5-HT1B-Donitriptan-Go/β1/γ2
26.09Single6OMMWKYMVX6OMM-FPR2-ALX-WKYMVX-Gi1/β1/γ2
26.09Single6OS9JMV4496OS9-NTS1-JMV449-Gi1/β1/γ2
26.09Single6PT3DPI-2876PT3-δ-DPI-287
26.09Single6RZ6ONO-25703666RZ6-CysLT2-ONO-2570366
26.09Single7S8LCortistatin-147S8L-MRGPRX2-Cortistatin-14-chim(NtGi2L-Gs-CtGq)/β1/γ2
26.09Single8SAI1-Oleoyl-2-Hydroxy-Sn-Glycero-3-Phospho-L-Serine8SAI-GPR34-1-Oleoyl-2-Hydroxy-Sn-Glycero-3-Phospho-L-Serine-Gi1/β1/γ2
26.09Single8X5YAstemizole8X5Y-H1-Astemizole
26.09Single8XX6CXCL88XX6-CXCR2-CXCL8-Go/β1/γ2
26.09Consensuscb2_offOrthosteric Ligand5ZTY-CB2-AM10257
26.09Consensuscxcr3_onOrthosteric Ligand8HNK-CXCR3-CXCL11-Gi1/β1/γ2 8HNL-CXCR3-PS372424-Gi1/β1/γ2
26.09Consensuscxcr_on_gpOrthosteric Ligandcxcr3_on_gp cxcr4_on_gp cxcr1_on_gp cxcr2_on_gp
26.09Consensusformylpeptide_onOrthosteric Ligandfpr2-alx_on fpr1-alx_on
26.09Consensuskiss1_onOrthosteric Ligand8ZJD-Kiss1-Kisspeptin-10-chim(NtGi1-Gq)/β1/γ1
26.09Consensuskisspeptin_onOrthosteric Ligandkiss1_on
26.09Consensusox2_onOrthosteric Ligand7L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/β1/γ2 7SQO-OX2-TAK-925-Gi1/β1/γ2 7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/β1/γ2
26.09Consensusox2_on_gpOrthosteric Ligand7L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/β1/γ2 7SQO-OX2-TAK-925-Gi1/β1/γ2 7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/β1/γ2
25.93Single7F9YGhrelin-287F9Y-Ghrelin-Ghrelin-28-chim(NtGi1-Gs-CtGq)/β1/γ2
25.93Single8E3ZVIP8E3Z-VPAC1-VIP-Gs/β1/γ2
25.93Single8XGOTAK4488XGO-Kiss1-TAK448-chim(NtGi1-Gq)/β1/γ2
25.93Single8XQEApelin-138XQE-Apelin-Apelin-13-Gi1/β1/γ2
25.93Consensuschemokine_offOrthosteric Ligandccr_off cxcr_off
25.93Consensuscxcr_offOrthosteric Ligandcxcr3_off cxcr4_off
25.93Consensusmc1_onOrthosteric Ligand7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2 7F4D-MC1-α-MSH-chim(NtGi1-Gs)/β1/γ2 7F4I-MC1-SHU9119-chim(NtGi1-Gs)/β1/γ2
25.93Consensusmc1_on_gpOrthosteric Ligand7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2 7F4D-MC1-α-MSH-chim(NtGi1-Gs)/β1/γ2 7F4I-MC1-SHU9119-chim(NtGi1-Gs)/β1/γ2
25.93Consensussst5_on_gpOrthosteric Ligand8X8L-SST5-Cortistatin-chim(NtGi1-Gs-CtGi1)/β1/γ2 8X8N-SST5-Octreotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
25.00Single2Y00Dobutamine2Y00-β1-Dobutamine
25.00Single2Y03Isoprenaline2Y03-β1-Isoprenaline
25.00Single4IARErgotamine4IAR-5-HT1B-Ergotamine
25.00Single4JKVTaladegib4JKV-SMO-Taladegib
25.00Single4NTJAZD12834NTJ-P2Y12-AZD1283
25.00Single4PHUFasiglifam4PHU-FFA1-Fasiglifam
25.00Single4XT1Fractalkine4XT1-US28-Fractalkine
25.00Single4ZJ8Suvorexant4ZJ8-OX1-Suvorexant
25.00Single5JQHS-Carazolol5JQH-β2-S-Carazolol
25.00Single5N2RPSB-365N2R-A2A-PSB-36-Na
25.00Single5N2SPSB365N2S-A1-PSB36
25.00Single5OM4PubChem 1355666095OM4-A2A-PubChem 135566609-Na
25.00Single5TVNLSD5TVN-5-HT2B-LSD
25.00Single5X7DS-Carazolol5X7D-β2-S-Carazolol-PubChem 129318963
25.00Single5XPRBosentan5XPR-ETB-Bosentan
25.00Single6D32Cyclopamine6D32-SMO-Cyclopamine-Cyclopamine
25.00Single6GDGNECA6GDG-A2A-NECA-Gs/β1/γ1
25.00Single6KPCPubChem 1459158896KPC-CB2-PubChem 145915889
25.00Single6KUWPubChem 572132346KUW-α2c-PubChem 57213234
25.00Single6PS3S-Carvedilol6PS3-β2-S-Carvedilol
25.00Single6RZ4Pranlukast6RZ4-CysLT1-Pranlukast-Na
25.00Single6RZ8ONO-20803656RZ8-CysLT2-ONO-2080365
25.00Single6TO7Suvorexant6TO7-OX1-Suvorexant-Na
25.00Single6TP6Filorexant6TP6-OX1-Filorexant
25.00Single6W2XPubChem 237279706W2X-GABAB1, GABAB2-PubChem 5311042-PubChem 23727970
25.00Single6WIVPubChem 52923113; PubChem 529246456WIV-GABAB1, GABAB2-PubChem 52923113; PubChem 52924645
25.00Single7BVQS-Carazolol7BVQ-β1-S-Carazolol
25.00Single7C61Ergotamine7C61-5-HT1B-Ergotamine
25.00Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
25.00Single7RGPTirzepatide7RGP-GLP-1-Tirzepatide-chim(NtGi1-Gs)/β1/γ2
25.00Single7S0FIsoprenaline7S0F-β1-Isoprenaline-Gi1/β1/γ2
25.00Single7SK3CXCL127SK3-ACKR3-CXCL12
25.00Single7T6UCGEN-855A7T6U-FPR2-ALX-CGEN-855A-Gi1/β1/γ2
25.00Single7VABNon-Acylated Tirzepatide7VAB-GIP-Non-Acylated Tirzepatide-chim(NtGi1-Gs)/β1/γ2
25.00Single7VUHJNJ-635330547VUH-GPR139-JNJ-63533054-chim(Gs-CtGq)/β1/γ2
25.00Single7VV4Cortistatin-147VV4-MRGPRX2-Cortistatin-14
25.00Single7WC5Psilocin7WC5-5-HT2A-Psilocin
25.00Single7XK9Constrained Isoproterenol7XK9-β2-Constrained Isoproterenol-Na
25.00Single7XKAConstrained Epinephrine7XKA-β2-Constrained Epinephrine
25.00Single8DCRDobutamine8DCR-β1-Dobutamine-Gs/β1/γ2
25.00Single8DZRGR89,6968DZR-κ-GR89,696-chim(NtGi2-Gt3)/β1/γ2
25.00Single8EITDoconexent8EIT-FFA1-Doconexent-chim(NtGi1L-Gs-CtGq)/β1/γ2
25.00Single8GDZConstrained Epinephrine8GDZ-β2-Constrained Epinephrine-Gs/β1/γ2
25.00Single8GEBConstrained Epinephrine8GEB-β2-Constrained Epinephrine-Gs/β1/γ2
25.00Single8GEGConstrained Epinephrine8GEG-β2-Constrained Epinephrine-Gs/β1/γ2
25.00Single8GGBConstrained Epinephrine8GGB-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
25.00Single8GGEConstrained Epinephrine8GGE-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
25.00Single8GH1Constrained Epinephrine8GH1-β2-Constrained Epinephrine
25.00Single8GNEKW-63568GNE-A2A-KW-6356-Na
25.00Single8IZ4Lysophosphatidylserine8IZ4-GPR34-Lysophosphatidylserine-Gi1/β1/γ2
25.00Single8K8JFenofibrate8K8J-CB1-Fenofibrate-chim(Gs-CtGq)/β1/γ2
25.00Single8KFXLMD-0098KFX-CCR8-LMD-009-Gi1/β1/γ2
25.00Single8PKMBefiradol8PKM-5-HT1A-Befiradol-t7m-Gi1/β1/γ1
25.00Single8QOTNanobody-E8QOT-μ-Nanobody-E
25.00Single8S4DCMF-0198S4D-Apelin-CMF-019
25.00Single8U4OCXCL128U4O-CXCR4-CXCL12-Cholesterol-Gi1/β1/γ2
25.00Single8UNNConstrained Epinephrine8UNN-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
25.00Single8UNPConstrained Epinephrine8UNP-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
25.00Single8UUJFCH-22964138UUJ-HCA2-FCH-2296413-Gi1/β1/γ2
25.00Single8WKYPG-9348WKY-MC4-PG-934
25.00Single8WZ2Orexigenic Neuropeptide QRFP8WZ2-QRFP-Orexigenic Neuropeptide QRFP-chim(NtGi1L-Gs-CtGq)/β1/γ2
25.00Single8XGMChemerin8XGM-CML2-Chemerin-Gi1/β1/γ2
25.00Single8XWNCXCL88XWN-CXCR2-CXCL8
25.00Single8YH0NECA8YH0-A3A-NECA-Gi1/β1/γ2
25.00Single8ZJDKisspeptin-108ZJD-Kiss1-Kisspeptin-10-chim(NtGi1-Gq)/β1/γ1
25.00Single8ZSPLSD8ZSP-TA1-LSD-chim(NtGi1L-Gs-CtGq)/β1/γ2
25.00Single9AVLCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVL-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi3/β2/γ2
25.00Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
25.00Single9BKJCholecystokinin-89BKJ-CCKA-Cholecystokinin-8-chim(NtGi1-Gs-CtGq)/β1/γ2
25.00Single9L3YRetinoic acid receptor responder protein 29L3Y-CML2-Retinoic acid receptor responder protein 2-Gi1/β1/γ2
25.00Consensus5ht5_on_gpOrthosteric Ligand5ht5a_on_gp
25.00Consensus5ht5a_on_gpOrthosteric Ligand7X5H-5-HT5A-5-CT-Gi1/β1/γ2 7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/β1/γ2 7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/β1/γ2
25.00Consensusadrenergic_offOrthosteric Ligandalpha_off beta_off
25.00Consensusadrenergic_on_gpOrthosteric Ligandalpha_on_gp beta_on_gp
25.00Consensusalpha2c_offOrthosteric Ligand6KUW-α2c-PubChem 57213234
25.00Consensusalpha_offOrthosteric Ligandalpha1_off alpha2_off
25.00Consensusccr5_onOrthosteric Ligand7O7F-CCR5-6P4-CCL5-Gi1/β1/γ1 7F1Q-CCR5-MIP-1a-Gi1/β1/γ2
25.00Consensusccr_offOrthosteric Ligandccr2_off ccr5_off
25.00Consensuschemerin_on_gpOrthosteric Ligandcml1_on_gp
25.00Consensuscml1_onOrthosteric Ligand7YKD-CML1-Chemerin-9-Gi1/β1/γ2
25.00Consensuscxcr4_onOrthosteric Ligand8K3Z-CXCR4-CXCL12-Gi1/β1/γ1
25.00Consensuscyslt_offOrthosteric Ligandcyslt2_off cyslt1_off
25.00Consensusd4_onOrthosteric Ligand8IRU-D4-Rotigotine-chim(NtGi1-Gs-CtGi1)/β1/γ2
25.00Consensusgi_chemerinOrthosteric Ligand7YKD-CML1-Chemerin-9-Gi1/β1/γ2
25.00Consensusgi_proteinOrthosteric Ligandgi_chemokine gi_chemerin
25.00Consensusgq_kisspeptinOrthosteric Ligand8ZJD-Kiss1-Kisspeptin-10-chim(NtGi1-Gq)/β1/γ1
25.00Consensusgs_amineOrthosteric Ligandgs_5ht gs_adrenergic gs_dopamine gs_histamine gs_trace-amine
25.00Consensuskiss1_on_gpOrthosteric Ligand8ZJD-Kiss1-Kisspeptin-10-chim(NtGi1-Gq)/β1/γ1
25.00Consensuskisspeptin_on_gpOrthosteric Ligandkiss1_on_gp
25.00Consensusnop_onOrthosteric Ligand8F7X-NOP-Nociceptin-Gi1/β1/γ2
25.00Consensusnop_on_gpOrthosteric Ligand8F7X-NOP-Nociceptin-Gi1/β1/γ2
25.00Consensusprotein_on_gpOrthosteric Ligandchemokine_on_gp chemerin_on_gp
24.14Single7WVYAmyloid-Beta427WVY-FPR2-ALX-Amyloid-β42-Gi2/β1/γ2
24.14Single7YOONeuropeptide-Y7YOO-Y2-Neuropeptide-Y-Gi1/β1/γ2
24.14Single8ZJGChemerin8ZJG-CML1-Chemerin-Gi1/β1/γ2
24.14Single9K26PrRP319K26-PrRP-PrRP31-Gi1/β1/γ2
24.14Consensusnpy2_onOrthosteric Ligand7YOO-Y2-Neuropeptide-Y-Gi1/β1/γ2
24.14Consensusnpy2_on_gpOrthosteric Ligand7YOO-Y2-Neuropeptide-Y-Gi1/β1/γ2
24.00Single5XJM(Sar1,Ile8)-Angiotensin II5XJM-AT2-(Sar1,Ile8)-Angiotensin II
24.00Single6HLOAprepitant6HLO-NK1-Aprepitant
24.00Single7CUMPhospholipid7CUM-GABAB1, GABAB2-CGP54626-Phospholipid
24.00Single7W0NElabela7W0N-Apelin-Elabela-Gi1/β1/γ2
24.00Single8JBHSubstance-P8JBH-NK3-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
24.00Single8JZZC5a-desArg8JZZ-C5a1-C5a-desArg-Go/β1/γ2
24.00Single8XYDPlatelet Activating Factor8XYD-PAF-Platelet Activating Factor-Gi1/β1/γ2
24.00Single8Z7JAgonistic antibody8Z7J-Apelin-Agonistic antibody-Gi1/β1/γ2
24.00Consensusformylpeptide_on_gpOrthosteric Ligandfpr2-alx_on_gp fpr1-alx_on_gp
24.00Consensusghrelin_onOrthosteric Ligand7NA7-Ghrelin-Ghrelin-27-Gi1/β1/γ2 7F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/β1/γ2 7NA8-Ghrelin-PubChem 178024-Gi1/β1/γ2
24.00Consensusghrelin_on_gpOrthosteric Ligand7NA7-Ghrelin-Ghrelin-27-Gi1/β1/γ2 7F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/β1/γ2 7NA8-Ghrelin-PubChem 178024-Gi1/β1/γ2
24.00Consensusgq_class-aOrthosteric Ligandgq_peptide gq_amine gq_nucleotide
24.00Consensusmc5_onOrthosteric Ligand8INR-MC5-α-MSH-Ca-chim(NtGi1-Gs)/β1/γ2 8IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/β1/γ2
23.81Single2YDVNECA2YDV-A2A-NECA
23.81Single4IAQDihydroergotamine4IAQ-5-HT1B-Dihydroergotamine
23.81Single4UHRCGS216804UHR-A2A-CGS21680
23.81Single5A8E7-Methylcyanopindolol5A8E-β1-7-Methylcyanopindolol-Na
23.81Single5G53NECA5G53-A2A-NECA-Gs
23.81Single5TZRMK86665TZR-FFA1-MK8666
23.81Single5V57TC1145V57-SMO-TC114
23.81Single6J21Aprepitant6J21-NK1-Aprepitant
23.81Single6N4BMDMB-Fubinaca6N4B-CB1-MDMB-Fubinaca-Gi1/β1/γ2
23.81Single6RZ5Zafirlukast6RZ5-CysLT1-Zafirlukast-Na
23.81Single6WGTLSD6WGT-5-HT2A-LSD
23.81Single6Z8NSRI-98296Z8N-NTS1-SRI-9829
23.81Single7EW7SEW28717EW7-S1P1-SEW2871-Gi1/β1/γ2
23.81Single7F1TMIP-1a7F1T-CCR5-MIP-1a
23.81Single7S8MCortistatin-147S8M-MRGPRX2-Cortistatin-14-Gi1/β1/γ2
23.81Single7T2HLofentanil7T2H-μ-Lofentanil-Gi1/β1/γ2
23.81Single7U2LPubChem 1632012427U2L-μ-PubChem 163201242-Gi1/β1/γ2
23.81Single7WVXHumanin7WVX-FPR2-ALX-Humanin-Gi2/β1/γ2
23.81Single7XAVLanreotide7XAV-SST2-Lanreotide-Gi1/β1/γ2
23.81Single7XOWGastrin7XOW-CCKB-Gastrin-chim(NtGi1-Gq)/β1/γ2
23.81Single7XY7NECA7XY7-A2B-NECA-chim(NtGi1-Gs)/β1/γ2
23.81Single7Y24Octreotide7Y24-SST2-Octreotide-Go/β1/γ2
23.81Single7Y67C089 peptide7Y67-C5a1-C089 peptide-Gi1/β1/γ2
23.81Single8EF5Fentanyl8EF5-μ-Fentanyl-Gi1/β1/γ2
23.81Single8EFLSR170188EFL-μ-SR17018-Gi1/β1/γ2
23.81Single8FN1Neurotensin/Neuromedin-N8FN1-NTS1-Neurotensin/Neuromedin-N-chim(NtGi1-Go)/β1/γ2
23.81Single8IHHLUF62838IHH-HCA2-LUF6283-Gi1/β1/γ2
23.81Single8IRRRotigotine8IRR-D1-Rotigotine-Gs/β1/γ2
23.81Single8IRURotigotine8IRU-D4-Rotigotine-chim(NtGi1-Gs-CtGi1)/β1/γ2
23.81Single8IRVRotigotine8IRV-D5-Rotigotine-chim(NtGi1-Gs)/β1/γ2
23.81Single8JBGNeurokinin-B8JBG-NK3-Neurokinin-B-chim(NtGi1-Gs-CtGq)/β1/γ2
23.81Single8JXVClozapine8JXV-H4-Clozapine-Gi1/β1/γ2
23.81Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/β1/γ2
23.81Single8WJXADP8WJX-P2Y1-ADP-chim(Gs-CtGq)/β1/γ2
23.81Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/β1/γ2
23.81Single9F33FOB02-04A9F33-D3-FOB02-04A-Go1/β1/γ2
23.81Single9ITELPA9ITE-LPA6-LPA-chim(NtGi2-G13)/β1/γ2
23.81Consensusbeta2_onOrthosteric Ligand7DHI-β2-Salbutamol-Gs/β1/γ2 6NI3-β2-BI167107-Gs/β1/γ2
23.81Consensusbeta2_on_gpOrthosteric Ligand7DHI-β2-Salbutamol-Gs/β1/γ2 6NI3-β2-BI167107-Gs/β1/γ2
23.81Consensusd4_on_gpOrthosteric Ligand8IRU-D4-Rotigotine-chim(NtGi1-Gs-CtGi1)/β1/γ2
23.81Consensusd5_on_gpOrthosteric Ligand8IRV-D5-Rotigotine-chim(NtGi1-Gs)/β1/γ2
23.81Consensusgi_dopamineOrthosteric Ligand7JVR-D2-Bromoergocryptine-Gi1/β1/γ2 7CMV-D3-PD128907-Gi1/β1/γ2 7CMU-D3-Pramipexole-Gi1/β1/γ2 8IRS-D2-Rotigotine-Gi1/β1/γ2 8IRT-D3-Rotigotine-Gi1/β1/γ2
23.81Consensusgs_adrenergicOrthosteric Ligand7DHI-β2-Salbutamol-Gs/β1/γ2 7XJI-β3-Solabegron-Gs/β1/γ2 7JJO-β1-Isoprenaline-Gs/β1/γ2 6NI3-β2-BI167107-Gs/β1/γ2 8DCR-β1-Dobutamine-Gs/β1/γ2 7XJH-β3-Isoproterenol-Gs/β1/γ2 7DH5-β3-Mirabegron-Gs/β1/γ2
23.81Consensusp2y12_onOrthosteric Ligand7XXI-P2Y12-2MeSADP-Gi2/β1/γ2
23.81Consensusprotein_offOrthosteric Ligandchemokine_off grh_off
23.53Single4O9RCyclopamine4O9R-SMO-Cyclopamine
23.53Single6HLLCP999946HLL-NK1-CP99994
23.53Single6PH7Nerol6PH7-Rhodopsin-Nerol-Gt(CT)
23.53Single6TP4ACT-4622066TP4-OX1-ACT-462206
23.53Single6TQ4PubChem 160468446TQ4-OX1-PubChem 16046844-Na
23.53Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
23.53Single7T96LY21196207T96-M2-Acetylcholine-LY2119620-Go/β1/γ2
23.53Single7VDHC48/807VDH-MRGPRX2-C48/80-Gi1/β1/γ2
23.53Single7VUIJNJ-635330547VUI-GPR139-JNJ-63533054-GTP-chim(Gs-CtGq)/β1/γ2
23.53Single7XTASerotonin7XTA-5-HT4-Serotonin-Gi1/β1/γ2
23.53Single8EF6Morphine8EF6-μ-Morphine-Gi1/β1/γ2
23.53Single8UO3Constrained Epinephrine8UO3-β2-Constrained Epinephrine-GTP; Mg-Gs/β1/γ2
23.53Single8YH3N-methyladenosine8YH3-A3A-N-methyladenosine-Gi1/β1/γ2
23.53Single9L3ZLRH7-C29L3Z-CML1-LRH7-C2
23.53Consensus5ht4_onOrthosteric Ligand7XTA-5-HT4-Serotonin-Gi1/β1/γ2
23.53Consensus5ht4_on_gpOrthosteric Ligand7XTA-5-HT4-Serotonin-Gi1/β1/γ2
23.33Single5VAIGLP-15VAI-GLP-1-GLP-1-Gs/β1/γ2
23.33Single7TS0Urocortin7TS0-CRF2-Urocortin-chim(NtGi1L-Go)/β1/γ2
23.33Single7VGXNeuropeptide-Y7VGX-Y1-Neuropeptide-Y-Gi1/β1/γ2
23.08Single5WF5UK-4320975WF5-A2A-UK-432097
23.08Single6MEOEnvelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd46MEO-CCR5-Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4
23.08Single6W25SHU91196W25-MC4-SHU9119-Ca
23.08Single7RYCOxytocin7RYC-OT-Oxytocin-chim(NtGi2L-Gs-CtGq)/β1/γ2
23.08Single7XA3CCL27XA3-CCR2-CCL2-Gi1/β1/γ2
23.08Single8K6NPro-neuropeptide-Y8K6N-Y2-Pro-neuropeptide-Y-Gi2/β1/γ1
23.08Single8XGUTAK4488XGU-Kiss1-TAK448-Gi1/β1/γ2
23.08Single9IVMGLP-1 (Truncated)9IVM-GLP-1-GLP-1 (Truncated)-LSN3318839-chim(NtGi1-Gs)/β2/γ2
23.08Single9K27PrRP319K27-PrRP-PrRP31-chim(NtGi1-Gq)/β1/γ2
23.08Consensusccr2_onOrthosteric Ligand7XA3-CCR2-CCL2-Gi1/β1/γ2
23.08Consensusccr2_on_gpOrthosteric Ligand7XA3-CCR2-CCL2-Gi1/β1/γ2
23.08Consensusccr_onOrthosteric Ligandccr6_on ccr8_on ccr2_on ccr1_on ccr5_on
23.08Consensusfpr2-alx_onOrthosteric Ligand7WVX-FPR2-ALX-Humanin-Gi2/β1/γ2 7T6U-FPR2-ALX-CGEN-855A-Gi1/β1/γ2 7T6V-FPR2-ALX-fMLFII-Gi1/β1/γ2 7WVY-FPR2-ALX-Amyloid-β42-Gi2/β1/γ2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/β1/γ2 6OMM-FPR2-ALX-WKYMVX-Gi1/β1/γ2
23.08Consensusgi_somatostatinOrthosteric Ligand7WIC-SST2-Somatostatin-14-Gi1/β1/γ2 7XMS-SST4-Somatostatin-14-Gi1/β1/γ2 8X8L-SST5-Cortistatin-chim(NtGi1-Gs-CtGi1)/β1/γ2 7XMT-SST4-J-2156-Gi1/β1/γ2 7WIG-SST2-L-054,264-Gi1/β1/γ2 8X8N-SST5-Octreotide-chim(NtGi1-Gs-CtGi1)/β1/γ2 7YAE-SST2-Octreotide-Gi1/β1/γ2 7YAC-SST2-Paltusotine-Gi1/β1/γ2
23.08Consensussomatostatin_onOrthosteric Ligandsst2_on sst4_on sst5_on
23.08Consensussomatostatin_on_gpOrthosteric Ligandsst2_on_gp sst4_on_gp sst5_on_gp
22.73Single4AMIBucindolol4AMI-β1-Bucindolol
22.73Single4OR2FITM4OR2-mGlu1; mGlu1-FITM
22.73Single5UNHPubChem 1264564065UNH-AT2-PubChem 126456406
22.73Single6C1RPMX536C1R-C5a1-PMX53-Avacopan; Na
22.73Single6CM4Risperidone6CM4-D2-Risperidone
22.73Single6H7NS-Xamoterol6H7N-β1-S-Xamoterol
22.73Single6H7OCyanopindolol6H7O-β1-Cyanopindolol
22.73Single6RZ7ONO-25703666RZ7-CysLT2-ONO-2570366
22.73Single6VMSBromoergocryptine6VMS-D2-Bromoergocryptine-Gi1/β1/γ2
22.73Single6YVRNTS8-136YVR-NTS1-NTS8-13
22.73Single7EXDLasmiditan7EXD-5-HT1F-Lasmiditan-Gi1/β1/γ2
22.73Single7F55Bremelanotide7F55-MC4-Bremelanotide-Gs/β1/γ2
22.73Single7L1UOrexin7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/β1/γ2
22.73Single7MTRADX551647MTR-mGlu2; mGlu2-Glutamate-ADX55164
22.73Single7SUSPubChem 1227019087SUS-Apelin-PubChem 122701908
22.73Single7W0LPubChem 1227019087W0L-Apelin-PubChem 122701908-Gi1/β1/γ2
22.73Single7XMTJ-21567XMT-SST4-J-2156-Gi1/β1/γ2
22.73Single7XW5ML1097XW5-TSH-TSH-ML109-Gs/β1/γ2
22.73Single7XXI2MeSADP7XXI-P2Y12-2MeSADP-Gi2/β1/γ2
22.73Single7Y66BM2137Y66-C5a1-BM213-Gi1/β1/γ2
22.73Single7YMJTamsulosin7YMJ-Alpha1A-Tamsulosin
22.73Single8FYTLSD8FYT-5-HT1A-LSD-Gi1/β1/γ1
22.73Single8IRSRotigotine8IRS-D2-Rotigotine-Gi1/β1/γ2
22.73Single8IYWGSK2560738IYW-HCA2-GSK256073-Go/β1/γ2
22.73Single8J6DEP1418J6D-C3aB-EP141-Go/β1/γ2
22.73Single8JPCNeurotensin-(8-13)8JPC-NTS1-Neurotensin-(8-13)-PubChem 118610427; GDP; Mg-Gq; GRK2
22.73Single8JWZAB9288JWZ-A2A-AB928-Na
22.73Single8JZ7MK68928JZ7-HCA2-MK6892-Gi1/β1/γ2
22.73Single8T3QDocosa-4,7,10,13,16,19-Hexaenoic acid8T3Q-FFA4-Docosa-4,7,10,13,16,19-Hexaenoic acid-chim(NtGi2L-Gs-CtGq)/β1/γ2
22.73Single8XQJJN2418XQJ-Apelin-JN241
22.73Single8XQSCholesterol8XQS-TAS2R14-Cholesterol-Flufenamic acid-Gi1/β1/γ1
22.73Single8XX3CXCL38XX3-CXCR2-CXCL3-Go/β1/γ2
22.73Single9MQLIsoquinuclidine9MQL-κ-Isoquinuclidine
22.73Consensus5ht1f_onOrthosteric Ligand7EXD-5-HT1F-Lasmiditan-Gi1/β1/γ2
22.73Consensus5ht1f_on_gpOrthosteric Ligand7EXD-5-HT1F-Lasmiditan-Gi1/β1/γ2
22.73Consensusalpha1_offOrthosteric Ligandalpha1a_off
22.73Consensusalpha1a_offOrthosteric Ligand7YMJ-Alpha1A-Tamsulosin
22.73Consensusc3a_onOrthosteric Ligand8HK2-C3aB-C3a anaphylatoxin-Gi1/β1/γ2 8IA8-C3aB-E7 peptide-Gi1/β1/γ2
22.73Consensuscxcr_onOrthosteric Ligandcxcr3_on cxcr4_on cxcr1_on cxcr2_on
22.73Consensusd2_on_gpOrthosteric Ligand7JVR-D2-Bromoergocryptine-Gi1/β1/γ2 8IRS-D2-Rotigotine-Gi1/β1/γ2
22.73Consensusffa2_on_gpOrthosteric Ligand8J22-FFA2-TUG-1375-Gi1/β1/γ2
22.73Consensusgi_p2yOrthosteric Ligand7XXI-P2Y12-2MeSADP-Gi2/β1/γ2
22.73Consensusorexin_onOrthosteric Ligandox2_on
22.73Consensusp2y12_on_gpOrthosteric Ligand7XXI-P2Y12-2MeSADP-Gi2/β1/γ2
22.58Single6PB0Urocortin6PB0-CRF1-Urocortin-chim(NtGi1-Gs)/β1/γ2
22.58Single8ZJETAK-4488ZJE-Kiss1-TAK-448-chim(NtGi1-Gq)/β1/γ1
22.58Consensusbb2_onOrthosteric Ligand7W40-BB2-Bombesin-chim(NtGi1L-Gq)/β1/γ2 7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/β1/γ2
22.58Consensusbb2_on_gpOrthosteric Ligand7W40-BB2-Bombesin-chim(NtGi1L-Gq)/β1/γ2 7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/β1/γ2
22.58Consensusbombesin_onOrthosteric Ligandbb2_on
22.58Consensusbombesin_on_gpOrthosteric Ligandbb2_on_gp
22.58Consensusgi_npyOrthosteric Ligand8K6M-Y1-Neuropeptide-Y-Gi2/β1/γ1 7X9C-Y4-Pancreatic Hormone-Gi1/β1/γ2 7YOO-Y2-Neuropeptide-Y-Gi1/β1/γ2
22.58Consensusgq_bombesinOrthosteric Ligand7W40-BB2-Bombesin-chim(NtGi1L-Gq)/β1/γ2 7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/β1/γ2
22.58Consensusnpy_onOrthosteric Ligandnpy1_on npy2_on npy4_on
22.58Consensusnpy_on_gpOrthosteric Ligandnpy1_on_gp npy2_on_gp npy4_on_gp
22.50Single8GY7Corticotropin8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1
22.22Single2X72All-trans-Retinal2X72-Rhodopsin-All-trans-Retinal-Gt(CT)
22.22Single3VG9ZM-2413853VG9-A2A-ZM-241385-Antibody
22.22Single4BWBNeurotensin4BWB-NTS1-Neurotensin
22.22Single4QINSAG1.54QIN-SMO-SAG1.5
22.22Single5OLOTozadenant5OLO-A2A-Tozadenant-Na
22.22Single5WS3EMPA5WS3-OX2-EMPA
22.22Single6AKXA4R6AKX-CCR5-A4R
22.22Single6B73MP11046B73-κ-MP1104
22.22Single6FKBPubChem 1324730386FKB-Rhodopsin-PubChem 132473038
22.22Single6METEnvelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd46MET-CCR5-Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4
22.22Single6NWEOctyl-Beta-D-Glucopyranoside6NWE-Rhodopsin-Octyl-β-D-Glucopyranoside-Gt(CT)
22.22Single6O3CSAG21k6O3C-SMO-SAG21k-Cholesterol
22.22Single6OBAS-Alprenolol6OBA-β2-S-Alprenolol-GTPL11074
22.22Single6TODEMPA6TOD-OX1-EMPA-Na
22.22Single6ZA8RTI-3a6ZA8-NTS1-RTI-3a
22.22Single7F16TIP397F16-PTH2-TIP39-Gs/β1/γ2
22.22Single7F1ODopamine7F1O-D1-Dopamine-GDP; Mg-Gs/β1/γ2
22.22Single7F4HAfamelanotide7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2
22.22Single7FIMTirzepatide7FIM-GLP-1-Tirzepatide-Gs/β1/γ2
22.22Single7LD4Adenosine7LD4-A1-Adenosine-Gi2/β1/γ2
22.22Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
22.22Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
22.22Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
22.22Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
22.22Single7SRRLSD7SRR-5-HT2B-LSD-chim(NtGi2L-Gs-CtGq)/β1/γ2
22.22Single7SRSLSD7SRS-5-HT2B-LSD-Arrestin2
22.22Single7VIHCBP-3077VIH-S1P1-CBP-307-Gi1/β1/γ2
22.22Single7VUJJNJ-635330547VUJ-GPR139-JNJ-63533054-GDP-chim(Gs-CtGq)/β1/γ2
22.22Single7VV5C48/807VV5-MRGPRX2-C48/80-Gi1/β1/γ2
22.22Single7X2CFenoldopam7X2C-D1-Fenoldopam-Fenoldopam-Gs/β1/γ2
22.22Single7XRRLemborexant7XRR-OX2-Lemborexant
22.22Single8GGCConstrained Epinephrine8GGC-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
22.22Single8GGZConstrained Epinephrine8GGZ-β2-Constrained Epinephrine
22.22Single8GNGIstradefylline8GNG-A2A-Istradefylline
22.22Single8HDPAdenosine8HDP-A2B-Adenosine-Gs/β1/γ2
22.22Single8IEDA1LYA8IED-GPR156-A1LYA-Go/β1/γ2
22.22Single8IJANiacin8IJA-HCA2-Niacin-Gi1/β1/γ2
22.22Single8JPPSuccinic acid8JPP-Succinate-Succinic acid-chim(Gs-CtGq)/β1/γ1
22.22Single8JSOAMPH8JSO-TA1-AMPH-chim(NtGi1-Gs)/β1/γ2
22.22Single8SZGCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-chim(NtGi1-Gq)/β1/γ2
22.22Single8T3VDocosa-4,7,10,13,16,19-Hexaenoic acid8T3V-FFA1-Docosa-4,7,10,13,16,19-Hexaenoic acid-chim(NtGi2L-Gs-CtGq)/β1/γ2
22.22Single8WC4ZH86518WC4-TA1-ZH8651-chim(NtGi1-Gs)/β1/γ2
22.22Single8WCA2-Phenylethylamine8WCA-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/β1/γ2
22.22Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
22.22Single8WSTPro-MCH8WST-MCH2-Pro-MCH-chim(NtGi1L-Gs-CtGq)/β1/γ2
22.22Single8YW4Retatrutide8YW4-GIP-Retatrutide-chim(NtGi1-Gs)/β1/γ22
22.22Single9BA0A1AKN9BA0-CB1-A1AKN
22.22Single9C2FCa; Ca; Tryptophan; '6218; PO49C2F-CaS-Ca-Ca; Ca; Tryptophan; '6218; PO4
22.22Consensus5ht2_on_gpOrthosteric Ligand5ht2b_on_gp
22.22Consensus5ht2b_on_gpOrthosteric Ligand7SRR-5-HT2B-LSD-chim(NtGi2L-Gs-CtGq)/β1/γ2
22.22Consensusa1_onOrthosteric Ligand7LD4-A1-Adenosine-Gi2/β1/γ2
22.22Consensusa1_on_gpOrthosteric Ligand7LD4-A1-Adenosine-Gi2/β1/γ2
22.22Consensusfpr2-alx_on_gpOrthosteric Ligand7WVX-FPR2-ALX-Humanin-Gi2/β1/γ2 7T6U-FPR2-ALX-CGEN-855A-Gi1/β1/γ2 7T6V-FPR2-ALX-fMLFII-Gi1/β1/γ2 7WVY-FPR2-ALX-Amyloid-β42-Gi2/β1/γ2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/β1/γ2 6OMM-FPR2-ALX-WKYMVX-Gi1/β1/γ2
22.22Consensusmc5_on_gpOrthosteric Ligand8INR-MC5-α-MSH-Ca-chim(NtGi1-Gs)/β1/γ2 8IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/β1/γ2
22.22Consensusorexin_offOrthosteric Ligandox2_off ox1_off
22.22Consensusox1_offOrthosteric Ligand6TP6-OX1-Filorexant 6TP4-OX1-ACT-462206 6V9S-OX1-GTPL11403 6TOT-OX1-Lemborexant 6TP3-OX1-Nemorexant 6TQ6-OX1-PubChem 145714283 6TQ9-OX1-SB-408124 4ZJC-OX1-SB-674042 4ZJ8-OX1-Suvorexant 6TOD-OX1-EMPA-Na 6TOS-OX1-GSK1059865-Na 6TQ4-OX1-PubChem 16046844-Na
22.22Consensusox2_offOrthosteric Ligand5WQC-OX2-EMPA 6TPN-OX2-HTL6641 7XRR-OX2-Lemborexant 6TPJ-OX2-Suvorexant
21.88Single6LPBPACAP6LPB-PAC1-PACAP-Gs/β1/γ1
21.74Single4BVNCyanopindolol4BVN-β1-Cyanopindolol-Na
21.74Single4NC3Ergotamine4NC3-5-HT2B-Ergotamine
21.74Single4OR2FITM4OR2-mGlu1; mGlu1-FITM
21.74Single6K1QIRL25006K1Q-ETB-IRL2500
21.74Single6RZ9ONO-27703726RZ9-CysLT2-ONO-2770372
21.74Single7LLLExendin-47LLL-GLP-1-Exendin-4-Gs/β1/γ2
21.74Single7UM4AS26747237UM4-5-HT5A-AS2674723
21.74Single7WVVfMLFII7WVV-FPR2-ALX-fMLFII-Gi2/β1/γ2
21.74Single7X1UTRH7X1U-TRH-TRH-chim(NtGi2L-Gs-CtGq)/β1/γ2
21.74Single7X8RBOC57X8R-GLP-1-BOC5-Gs/β1/γ2
21.74Single8E9X2-Deoxycytidine8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/β1/γ2
21.74Single8E9YClozapine-N-oxide8E9Y-M3-Clozapine-N-oxide-chim(NtGi2L-Gs-CtGq)/β1/γ2
21.74Single8FN0Neurotensin/Neuromedin-N8FN0-NTS1-Neurotensin/Neuromedin-N-PubChem 118610427-chim(NtGi1-Go)/β1/γ2
21.74Single8FX5Xanomeline8FX5-M4-Xanomeline-Xanomeline-Gi1/β1/γ2
21.74Single8T3OTUG-8918T3O-FFA4-TUG-891-2Y5-chim(NtGi2L-Gs-CtGq)/β1/γ2
21.74Single8XVUCXCL28XVU-CXCR2-CXCL2
21.74Single8XWFCXCL38XWF-CXCR2-CXCL3
21.74Single8XXHCXCL28XXH-CXCR2-CXCL2-Go/β1/γ2
21.74Consensuscyslt2_offOrthosteric Ligand6RZ7-CysLT2-ONO-2570366 6RZ8-CysLT2-ONO-2080365 6RZ9-CysLT2-ONO-2770372
21.74Consensusendothelin_offOrthosteric Ligandetb_off
21.74Consensusetb_offOrthosteric Ligand5X93-ETB-K-8794 5XPR-ETB-Bosentan 6K1Q-ETB-IRL2500
21.74Consensusorexin_on_gpOrthosteric Ligandox2_on_gp
21.43Single5YQZGlucagon analogue5YQZ-Glucagon-Glucagon analogue
21.43Single6X18GLP-16X18-GLP-1-GLP-1-Gs/β1/γ2
21.43Single7WBJPACAP277WBJ-VPAC1-PACAP27-Gs/β1/γ2
21.43Single7X9BNeuropeptide-Y7X9B-Y2-Neuropeptide-Y-Gi1/β1/γ2
21.43Single7X9CPancreatic Hormone7X9C-Y4-Pancreatic Hormone-Gi1/β1/γ2
21.43Single8E3YPACAP278E3Y-VPAC1-PACAP27-Gs/β1/γ2
21.43Single8IODPG-9018IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/β1/γ2
21.43Single8WWKMCH8WWK-MCH1-MCH-Gi1/β1/γ2
21.43Consensusccr_on_gpOrthosteric Ligandccr6_on_gp ccr8_on_gp ccr2_on_gp ccr1_on_gp ccr5_on_gp
21.43Consensuschemokine_on_gpOrthosteric Ligandccr_on_gp cxcr_on_gp
21.43Consensuscml1_on_gpOrthosteric Ligand7YKD-CML1-Chemerin-9-Gi1/β1/γ2
21.43Consensusgi_apelinOrthosteric Ligand8XZH-Apelin-MM07-Gi1/β1/γ2 7W0M-Apelin-PubChem 122701908-Gi1/β1/γ2 8XZJ-Apelin-WN353-Gi1/β1/γ2 8XZF-Apelin-WN561-Gi1/β1/γ2 8XZG-Apelin-Apelin-13-Gi1/β1/γ2
21.43Consensusgi_chemokineOrthosteric Ligand6WWZ-CCR6-CCL20-Go/β1/γ2 8HNK-CXCR3-CXCL11-Gi1/β1/γ2 8K3Z-CXCR4-CXCL12-Gi1/β1/γ1 8IC0-CXCR1-Interleukin-8-Gi1/β1/γ2 6LFM-CXCR2-Interleukin-8-Gi1/β1/γ2 8KFX-CCR8-LMD-009-Gi1/β1/γ2 7F1Q-CCR5-MIP-1a-Gi1/β1/γ2 8HNL-CXCR3-PS372424-Gi1/β1/γ2 8KFY-CCR8-ZK-756326-Gi1/β1/γ2 7O7F-CCR5-6P4-CCL5-Gi1/β1/γ1 8U1U-CCR8-CCL1-Gi1/β1/γ2 7VLA-CCR1-CCL15(27-92)-Gi1/β1/γ2 7XA3-CCR2-CCL2-Gi1/β1/γ2
21.05Single1F8811-cis-Retinal1F88-Rhodopsin-11-cis-Retinal
21.05Single3UZC4-(3-amino-5-phenyl-1,2,4-triazin-6-yl)-2-chlorophenol3UZC-A2A-4-(3-amino-5-phenyl-1,2,4-triazin-6-yl)-2-chlorophenol
21.05Single4LDOL-Epinephrine4LDO-β2-L-Epinephrine
21.05Single4MBSMaraviroc4MBS-CCR5-Maraviroc
21.05Single4N6HNaltrindole4N6H-δ-Naltrindole-Na
21.05Single4ZJCSB-6740424ZJC-OX1-SB-674042
21.05Single5K2BZM-2413855K2B-A2A-ZM-241385-Na
21.05Single5TE3Octyl-Beta-D-Glucopyranoside5TE3-Rhodopsin-Octyl-β-D-Glucopyranoside
21.05Single5UVIZM-2413855UVI-A2A-ZM-241385
21.05Single6IQLL7458706IQL-D4-L745870
21.05Single6KUXRS-799486KUX-α2a-RS-79948
21.05Single6ME32-Phenylmelatonin6ME3-MT1-2-Phenylmelatonin
21.05Single6PELCitronellol6PEL-Rhodopsin-Citronellol-Gt(CT)
21.05Single6PS0S-Carazolol6PS0-β2-S-Carazolol
21.05Single6PS4ICI118-5516PS4-β2-ICI118-551
21.05Single6PS5S-Propranolol6PS5-β2-S-Propranolol
21.05Single6PS82-Phenylmelatonin6PS8-MT1-2-Phenylmelatonin
21.05Single6TOSGSK10598656TOS-OX1-GSK1059865-Na
21.05Single6TP3Nemorexant6TP3-OX1-Nemorexant
21.05Single6TPGEMPA6TPG-OX2-EMPA
21.05Single6TPNHTL66416TPN-OX2-HTL6641
21.05Single6V9SGTPL114036V9S-OX1-GTPL11403
21.05Single6WJCMuscarinic toxin 76WJC-M1-Atropine-Muscarinic toxin 7
21.05Single6XBLSAG6XBL-SMO-SAG-Cholesterol-Gi1/β1/γ2
21.05Single7CKWFenoldopam7CKW-D1-Fenoldopam-Gs/β1/γ2
21.05Single7CKZDopamine7CKZ-D1-Dopamine-Mevidalen-Gs/β1/γ2
21.05Single7CMUPramipexole7CMU-D3-Pramipexole-Gi1/β1/γ2
21.05Single7EJ8Brimonidine7EJ8-α2a-Brimonidine-Go/β1/γ2
21.05Single7EJADexmedetomidine7EJA-α2a-Dexmedetomidine-Go/β1/γ2
21.05Single7F0TDopamine7F0T-D1-Dopamine-Gs/β1/γ2
21.05Single7F1ZDopamine7F1Z-D1-Dopamine-GDP-Gs/β1/γ2
21.05Single7F61PF-036547467F61-H3-PF-03654746-Cholesterol
21.05Single7RANPubChem 1645758477RAN-5-HT2A-PubChem 164575847-chim(NtGi2L-Gs-CtGq)/β1/γ2
21.05Single7T94PubChem 576644067T94-M2-Acetylcholine-PubChem 57664406-chim(NtGi1-Go)/β1/γ2
21.05Single7UM7Methylergometrine7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/β1/γ2
21.05Single7VV6C48/807VV6-MRGPRX2-C48/80
21.05Single7XXH2MeSADP7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/β1/γ2
21.05Single7ZI0SAG7ZI0-SMO-SAG-Cholesterol
21.05Single8GG5Constrained Epinephrine8GG5-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
21.05Single8GG7Constrained Epinephrine8GG7-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
21.05Single8GGLConstrained Epinephrine8GGL-β2-Constrained Epinephrine
21.05Single8GGMConstrained Epinephrine8GGM-β2-Constrained Epinephrine
21.05Single8GGPConstrained Epinephrine8GGP-β2-Constrained Epinephrine
21.05Single8GGQConstrained Epinephrine8GGQ-β2-Constrained Epinephrine
21.05Single8GGSConstrained Epinephrine8GGS-β2-Constrained Epinephrine
21.05Single8GGTConstrained Epinephrine8GGT-β2-Constrained Epinephrine
21.05Single8GGXConstrained Epinephrine8GGX-β2-Constrained Epinephrine
21.05Single8H4LDoconexent8H4L-FFA4-Doconexent-chim(NtGi1-Gs-CtGq)/β1/γ2
21.05Single8HQN9-S-HODE8HQN-GPR132-9-S-HODE-Gi1/β1/γ2
21.05Single8IHKAcifran8IHK-HCA3-Acifran
21.05Single8IY9Niacin8IY9-HCA2-Niacin-Go/β1/γ2
21.05Single8JERAcipimox8JER-HCA2-Acipimox-Go/β1/γ2
21.05Single8JLQFenoldopam8JLQ-TA1-Fenoldopam-Gs/β1/γ2
21.05Single8K2WAMG4878K2W-CXCR3-AMG487
21.05Single8K5CAcipimox8K5C-HCA2-Acipimox
21.05Single8THLEpinephrine8THL-Alpha1A-Epinephrine-chim(NtGi2L-Gs-CtGq)/β1/γ2
21.05Single8UNLConstrained Epinephrine8UNL-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
21.05Single8UNOConstrained Epinephrine8UNO-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
21.05Single8UO1Constrained Epinephrine8UO1-β2-Constrained Epinephrine-GTP; Mg-Gs/β1/γ2
21.05Single8VVGGB188VVG-κ-GB18-Gi1/β1/γ2
21.05Single8WC8ZH86518WC8-TA1-ZH8651-chim(NtGi1-Gs)/β1/γ2
21.05Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
21.05Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/β1/γ2
21.05Single9ASBCa; Ca; Cyclomethyltryptophan; 9IG; PO49ASB-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
21.05Single9ASBCa; Ca; Cyclomethyltryptophan; 9IG; PO49ASB-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
21.05Single9AVGCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVG-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs)/β1/γ2
21.05Single9BJKNaloxone9BJK-μ-Naloxone-NAM
21.05Consensus5ht_on_gpOrthosteric Ligand5ht1_on_gp 5ht2_on_gp 5ht4_on_gp 5ht5_on_gp 5ht6_on_gp 5ht7_on_gp
21.05Consensusalpha1_onOrthosteric Ligandalpha1a_on
21.05Consensusalpha1_on_gpOrthosteric Ligandalpha1a_on_gp
21.05Consensusalpha1a_onOrthosteric Ligand7EJ0-α2a-L-Norepinephrine-Go/β1/γ2 7EJ8-α2a-Brimonidine-Go/β1/γ2 7EJA-α2a-Dexmedetomidine-Go/β1/γ2 7EJK-α2a-Oxymetazoline-Go/β1/γ2 7W6P-α2a-N-pyridin-4-ylisoquinolin-4-amine-Go/β1/γ2 7W7E-α2a-PubChem 164946676-Go/β1/γ2
21.05Consensusalpha1a_on_gpOrthosteric Ligand7EJ0-α2a-L-Norepinephrine-Go/β1/γ2 7EJ8-α2a-Brimonidine-Go/β1/γ2 7EJA-α2a-Dexmedetomidine-Go/β1/γ2 7EJK-α2a-Oxymetazoline-Go/β1/γ2 7W6P-α2a-N-pyridin-4-ylisoquinolin-4-amine-Go/β1/γ2 7W7E-α2a-PubChem 164946676-Go/β1/γ2
21.05Consensuscxcr2_onOrthosteric Ligand6LFM-CXCR2-Interleukin-8-Gi1/β1/γ2
21.05Consensuscxcr3_offOrthosteric Ligand8K2W-CXCR3-AMG487
21.05Consensusd3_onOrthosteric Ligand7CMV-D3-PD128907-Gi1/β1/γ2 8IRT-D3-Rotigotine-Gi1/β1/γ2 7CMU-D3-Pramipexole-Gi1/β1/γ2
21.05Consensusd3_on_gpOrthosteric Ligand7CMV-D3-PD128907-Gi1/β1/γ2 8IRT-D3-Rotigotine-Gi1/β1/γ2 7CMU-D3-Pramipexole-Gi1/β1/γ2
21.05Consensusp2y1_on_gpOrthosteric Ligand7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/β1/γ2
20.83Single6W2YPubChem 237279706W2Y-GABAB1; GABAB1-PubChem 5311042-PubChem 23727970
20.83Single6XBJCholesterol6XBJ-SMO-Cholesterol-Gi1/β1/γ2
20.83Single7AUESetmelanotide7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2
20.83Single7F2OBradykinin7F2O-BK2-Bradykinin-chim(NtGi1-Gs-CtGq)/β1/γ2
20.83Single7F8WGastrin-177F8W-CCKB-Gastrin-17-chim(NtGsL-Gq)/β1/γ2
20.83Single7F9ZGHRP-67F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/β1/γ2
20.83Single7SK9CCX6627SK9-ACKR3-CCX662
20.83Single7T11Octreotide7T11-SST2-Octreotide-Gi3/β1/γ2
20.83Single7X8SWB4-247X8S-GLP-1-WB4-24-Gs/β1/γ2
20.83Single8IA7Cholecystokinin-88IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/β1/γ2
20.83Single8IEIA1LYA8IEI-GPR156-A1LYA
20.83Single8J22TUG-13758J22-FFA2-TUG-1375-Gi1/β1/γ2
20.83Single8JLRA776368JLR-TA1-A77636-chim(NtGi1-Gs)/β1/γ2
20.83Single8XQJJN2418XQJ-Apelin-JN241
20.83Single8XQLCholesterol8XQL-TAS2R14-Cholesterol-Aristolochic acid A-Gt3/β1/γ1
20.83Single8XZFWN5618XZF-Apelin-WN561-Gi1/β1/γ2
20.83Single8Z74Agonistic antibody8Z74-Apelin-Agonistic antibody
20.83Single8Z74Agonistic antibody8Z74-Apelin-Agonistic antibody
20.83Single9EAJNanobody AT2099EAJ-AT1-Nanobody AT209
20.83Consensuscxcr4_offOrthosteric Ligand4RWS-CXCR4-vMIP-II 3OE0-CXCR4-CVX15 3OE6-CXCR4-IT1t
20.83Consensusgq_cckOrthosteric Ligand8IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/β1/γ2 7XOW-CCKB-Gastrin-chim(NtGi1-Gq)/β1/γ2 7EZM-CCKA-Cholecystokinin-8-chim(NtGsL-Gq)/β1/γ2 7F8W-CCKB-Gastrin-17-chim(NtGsL-Gq)/β1/γ2
20.83Consensusnmur1_onOrthosteric Ligand7W53-NMUR1-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
20.69Single7RA3GIP7RA3-GIP-GIP-chim(NtGi1-Gs)/β1/γ2
20.69Single7W3ZGastrin Releasing Peptide7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/β1/γ2
20.69Single7YKDChemerin-97YKD-CML1-Chemerin-9-Gi1/β1/γ2
20.69Single8E3XPACAP278E3X-PAC1-PACAP27-Gs/β1/γ2
20.69Single8H0PNMB308H0P-BB1-NMB30-chim(NtGi1-Gs-CtGq)/β1/γ2
20.69Single8JISPeptide-158JIS-GLP-1-Peptide-15-chim(NtGi1-Gs)/β1/γ2
20.69Single9J1Pg1:Ox9J1P-GLP-1-g1:Ox-chim(NtGi1-Gs)/β1/γ2
20.69Consensusnpy4_onOrthosteric Ligand7X9C-Y4-Pancreatic Hormone-Gi1/β1/γ2
20.69Consensusnpy4_on_gpOrthosteric Ligand7X9C-Y4-Pancreatic Hormone-Gi1/β1/γ2
20.00Single2VT4Cyanopindolol2VT4-β1-Cyanopindolol
20.00Single3NY8ICI118-5513NY8-β2-ICI118-551
20.00Single3ZPQ4-(piperazin-1- yl)-1H-indole3ZPQ-β1-4-(piperazin-1- yl)-1H-indole-Na
20.00Single3ZPR4-methyl-2-(piperazin-1-yl)3ZPR-β1-4-methyl-2-(piperazin-1-yl)-Na
20.00Single4AMJS-Carvedilol4AMJ-β1-S-Carvedilol
20.00Single4EA3PubChem 102965614EA3-NOP-PubChem 10296561
20.00Single4GBRS-Carazolol4GBR-β2-S-Carazolol
20.00Single4J4QOctyl Beta-D-Glucopyranoside4J4Q-Rhodopsin-Octyl β-D-Glucopyranoside-Gt(CT)
20.00Single4QKX35V4QKX-β2-35V
20.00Single4X1HNonyl-Beta-D-Glucopyranoside4X1H-Rhodopsin-Nonyl-β-D-Glucopyranoside-Gt(CT)
20.00Single5DHGC-355DHG-NOP-C-35
20.00Single5DHHSB-6121115DHH-NOP-SB-612111
20.00Single5MZJTheophylline5MZJ-A2A-Theophylline-Na
20.00Single5OLZPubChem 1355666095OLZ-A2A-PubChem 135566609-Na
20.00Single5OM1PubChem 1355666095OM1-A2A-PubChem 135566609-Na
20.00Single5T04Neurotensin5T04-NTS1-Neurotensin
20.00Single5TGZAM65385TGZ-CB1-AM6538
20.00Single6B3JExendin-P56B3J-GLP-1-Exendin-P5-Gs/β1/γ2
20.00Single6D27CAY104716D27-DP2-CAY10471
20.00Single6DRXLisuride6DRX-5-HT2B-Lisuride
20.00Single6FKDPubChem 1373491836FKD-Rhodopsin-PubChem 137349183
20.00Single6GPSMK08126GPS-CCR2-MK0812
20.00Single6H7MSalbutamol6H7M-β1-Salbutamol
20.00Single6PS1Timolol6PS1-β2-Timolol
20.00Single6PS2S-Alprenolol6PS2-β2-S-Alprenolol
20.00Single6TOTLemborexant6TOT-OX1-Lemborexant
20.00Single6UVAAdrenomedullin-26UVA-CT Like (AM2)-Adrenomedullin-2-Gs/β1/γ2; RAMP3
20.00Single6VCBGLP-16VCB-GLP-1-GLP-1-LSN3160440-Gs/β1/γ2
20.00Single6X1ADanuglipron6X1A-GLP-1-Danuglipron-Gs/β1/γ2
20.00Single7BTSL-Epinephrine7BTS-β1-L-Epinephrine
20.00Single7BU6L-Norepinephrine7BU6-β1-L-Norepinephrine
20.00Single7CFMP3957CFM-GPBA-P395-Gs/β1/γ2
20.00Single7DB6Ramelteon7DB6-MT1-Ramelteon-Gi1/β1/γ2
20.00Single7DTYGIP7DTY-GIP-GIP-Gs/β1/γ2
20.00Single7F8XNN90567F8X-CCKA-NN9056
20.00Single7FIHOrg435537FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/β1/γ2
20.00Single7FIYTirzepatide7FIY-GIP-Tirzepatide-Gs/β1/γ2
20.00Single7LCIDanuglipron7LCI-GLP-1-Danuglipron-Gs/β1/γ2
20.00Single7NA8PubChem 1780247NA8-Ghrelin-PubChem 178024-Gi1/β1/γ2
20.00Single7QA8Peptide7QA8-STE2-Peptide
20.00Single7QA8Peptide7QA8-STE2-Peptide
20.00Single7S1MEx4-D-Ala7S1M-GLP-1-Ex4-D-Ala-Gs/β1/γ2
20.00Single7SCGFH2107SCG-μ-FH210-Gi1/β1/γ2
20.00Single7T2GMitragynine Pseudoindoxyl7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2
20.00Single7T6VfMLFII7T6V-FPR2-ALX-fMLFII-Gi1/β1/γ2
20.00Single7TRQVU04671547TRQ-M4-Iperoxo-VU0467154-Gi1/β1/γ2
20.00Single7VGZRemalteon7VGZ-MT1-Remalteon-Gi1/β1/γ2
20.00Single7VKTLTB47VKT-BLT1-LTB4-Gi1/β1/γ2
20.00Single7VQXPACAP277VQX-VPAC1-PACAP27-Gs/β1/γ2
20.00Single7W53Neuromedin-U-257W53-NMUR1-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
20.00Single7WC7Lisuride7WC7-5-HT2A-Lisuride
20.00Single7WKDTRH7WKD-TRH-TRH-chim(NtGi1-Gs-CtGq)/β1/γ2
20.00Single7X2CFenoldopam7X2C-D1-Fenoldopam-Fenoldopam-Gs/β1/γ2
20.00Single7XAUOctreotide7XAU-SST2-Octreotide-Gi1/β1/γ2
20.00Single7XKEBeta-Hydroxyandrosterone7XKE-ADGRG2-β-Hydroxyandrosterone-chim(NtGi1-Gs)/β1/γ2
20.00Single7XTC5-CT7XTC-5-HT7-5-CT-Gs/β1/γ2
20.00Single8CICEtrumadenant8CIC-A2A-Etrumadenant-Na
20.00Single8DWGProenkephalin-A8DWG-MRGPRX1-Proenkephalin-A-ML382-chim(NtGi2L-Gs-CtGq)/β1/γ2
20.00Single8DZSGR89,6968DZS-κ-GR89,696-chim(NtGi2-Gz)/β1/γ2
20.00Single8FU6Glucagon derivative ZP37808FU6-Glucagon-Glucagon derivative ZP3780-Gs/β1/γ2
20.00Single8GE3Constrained Epinephrine8GE3-β2-Constrained Epinephrine-Gs/β1/γ2
20.00Single8GE9Constrained Epinephrine8GE9-β2-Constrained Epinephrine-Gs/β1/γ2
20.00Single8GECConstrained Epinephrine8GEC-β2-Constrained Epinephrine-Gs/β1/γ2
20.00Single8GEEConstrained Epinephrine8GEE-β2-Constrained Epinephrine-Gs/β1/γ2
20.00Single8GEHConstrained Epinephrine8GEH-β2-Constrained Epinephrine-Gs/β1/γ2
20.00Single8GFVConstrained Epinephrine8GFV-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
20.00Single8GFWConstrained Epinephrine8GFW-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
20.00Single8GFXConstrained Epinephrine8GFX-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
20.00Single8GFZConstrained Epinephrine8GFZ-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
20.00Single8GG0Constrained Epinephrine8GG0-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
20.00Single8GG1Constrained Epinephrine8GG1-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
20.00Single8GG3Constrained Epinephrine8GG3-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
20.00Single8GG4Constrained Epinephrine8GG4-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
20.00Single8GG6Constrained Epinephrine8GG6-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
20.00Single8GG9Constrained Epinephrine8GG9-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
20.00Single8GGIConstrained Epinephrine8GGI-β2-Constrained Epinephrine
20.00Single8GGJConstrained Epinephrine8GGJ-β2-Constrained Epinephrine
20.00Single8GGKConstrained Epinephrine8GGK-β2-Constrained Epinephrine
20.00Single8GGNConstrained Epinephrine8GGN-β2-Constrained Epinephrine
20.00Single8GGOConstrained Epinephrine8GGO-β2-Constrained Epinephrine
20.00Single8GGUConstrained Epinephrine8GGU-β2-Constrained Epinephrine
20.00Single8HVINOX-6-78HVI-GPR132-NOX-6-7-Gi1/β1/γ2
20.00Single8IEBA1LYA8IEB-GPR156-A1LYA
20.00Single8IEPA1LYA8IEP-GPR156-A1LYA
20.00Single8IEPA1LYA8IEP-GPR156-A1LYA
20.00Single8INRAlpha-MSH8INR-MC5-α-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
20.00Single8IRTRotigotine8IRT-D3-Rotigotine-Gi1/β1/γ2
20.00Single8IZBLysophosphatidylserine8IZB-GPR174-Lysophosphatidylserine-Gs/β1/γ2
20.00Single8J6PNiacin8J6P-HCA2-Niacin-Compound 9n-Gi1/β1/γ2
20.00Single8JD0NAM5638JD0-mGlu2; mGlu3-Glutamate-NAM563
20.00Single8JHNMMF8JHN-HCA2-MMF-Go/β1/γ2
20.00Single8JIINiacin8JII-HCA2-Niacin-Compound 9n-Gi1/β1/γ2
20.00Single8JLZST19368JLZ-5-HT6-ST1936-Gs/β1/γ2
20.00Single8KEXDCA-3P8KEX-MRGPRX4-DCA-3P
20.00Single8KFYZK-7563268KFY-CCR8-ZK-756326-Gi1/β1/γ2
20.00Single8PWNTheophylline8PWN-A2A-Theophylline
20.00Single8UGYMianserin8UGY-5-HT1E-Mianserin-Gi1/β1/γ1
20.00Single8UH3Setiptiline8UH3-5-HT1E-Setiptiline-Gi1/β1/γ1
20.00Single8UNQConstrained Epinephrine8UNQ-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
20.00Single8UNRConstrained Epinephrine8UNR-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
20.00Single8UNUConstrained Epinephrine8UNU-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
20.00Single8UNYConstrained Epinephrine8UNY-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
20.00Single8W87METH8W87-TA1-METH-chim(NtGi1L-Gs)/β1/γ2
20.00Single8WWLMCH8WWL-MCH1-MCH-Gi1/β1/γ2
20.00Single8YH5Riboprine8YH5-A3A-Riboprine-Gi1/β1/γ2
20.00Single8YICSAR2477998YIC-S1P1-SAR247799-Gi1/β1/γ2
20.00Single8ZBEOctreotide8ZBE-SST5-Octreotide-Gi1/β1/γ1
20.00Single8ZSSRO52633978ZSS-TA1-RO5263397-chim(NtGi1-Gs)/β1/γ2
20.00Single9B9ZA1AKO9B9Z-CB1-A1AKO
20.00Single9CBMDexmedetomidine9CBM-α2a-Dexmedetomidine-Gi1/β1/γ2
20.00Single9IMATalquetamab9IMA-GPRC5D-Talquetamab
20.00Single9IV25alpha-DHT9IV2-ADGRD1-5α-DHT-chim(NtGi1-Gs)/β1/γ2
20.00Consensus5ht6_onOrthosteric Ligand7XTB-5-HT6-Serotonin-Gs/β1/γ2 8JLZ-5-HT6-ST1936-Gs/β1/γ2
20.00Consensus5ht6_on_gpOrthosteric Ligand7XTB-5-HT6-Serotonin-Gs/β1/γ2 8JLZ-5-HT6-ST1936-Gs/β1/γ2
20.00Consensus5ht7_onOrthosteric Ligand7XTC-5-HT7-5-CT-Gs/β1/γ2
20.00Consensus5ht7_on_gpOrthosteric Ligand7XTC-5-HT7-5-CT-Gs/β1/γ2
20.00Consensusadrenergic_onOrthosteric Ligandalpha_on beta_on
20.00Consensusalicarboxylic_on_gpOrthosteric Ligandsuccinate_on_gp hca_on_gp
20.00Consensusalpha_onOrthosteric Ligandalpha1_on alpha2_on
20.00Consensusblt1_onOrthosteric Ligand7VKT-BLT1-LTB4-Gi1/β1/γ2
20.00Consensusblt1_on_gpOrthosteric Ligand7VKT-BLT1-LTB4-Gi1/β1/γ2
20.00Consensusblt_onOrthosteric Ligandblt1_on
20.00Consensusblt_on_gpOrthosteric Ligandblt1_on_gp
20.00Consensusccr2_offOrthosteric Ligand6GPS-CCR2-MK0812
20.00Consensuschemokine_onOrthosteric Ligandccr_on cxcr_on
20.00Consensusd5_onOrthosteric Ligand8IRV-D5-Rotigotine-chim(NtGi1-Gs)/β1/γ2
20.00Consensusdopamine_offOrthosteric Ligandd2_off d3_off
20.00Consensusdopamine_onOrthosteric Ligandd2_on d1_on d3_on d4_on d5_on
20.00Consensusdopamine_on_gpOrthosteric Ligandd2_on_gp d1_on_gp d3_on_gp d4_on_gp d5_on_gp
20.00Consensusgi_alicarboxylicOrthosteric Ligandgi_hca gi_succinate
20.00Consensusgi_hcaOrthosteric Ligand8J6R-HCA2-MK6892-Gi1/β1/γ2 8JIM-HCA2-MMF-Gi1/β1/γ2 8IHI-HCA2-Acifran-Gi1/β1/γ2 8IHH-HCA2-LUF6283-Gi1/β1/γ2 8I7V-HCA2-Acipimox-Gi1/β1/γ2 8I7W-HCA2-GSK256073-Gi1/β1/γ2
20.00Consensusgi_leukotrieneOrthosteric Ligand7VKT-BLT1-LTB4-Gi1/β1/γ2
20.00Consensusgs_trace-amineOrthosteric Ligand8W88-TA1-SEP-363856-Gs/β1/γ2 8JLJ-TA1-T1AM-chim(NtGi1-Gs)/β1/γ2 8JLO-TA1-Ulotaront-Gs/β1/γ2 8WC4-TA1-ZH8651-chim(NtGi1-Gs)/β1/γ2 8WC7-TA1-ZH8667-chim(NtGi1-Gs)/β1/γ2 8JLR-TA1-A77636-chim(NtGi1-Gs)/β1/γ2 8JSO-TA1-AMPH-chim(NtGi1-Gs)/β1/γ2 8W87-TA1-METH-chim(NtGi1L-Gs)/β1/γ2 8W89-TA1-PEA-chim(NtGi1L-Gs)/β1/γ2 8JLP-TA1-Ralmitaront-Gs/β1/γ2 8W8A-TA1-RO5256390-chim(NtGi1L-Gs)/β1/γ2
20.00Consensushca2_onOrthosteric Ligand8J6R-HCA2-MK6892-Gi1/β1/γ2 8JIM-HCA2-MMF-Gi1/β1/γ2 8I7V-HCA2-Acipimox-Gi1/β1/γ2 8I7W-HCA2-GSK256073-Gi1/β1/γ2 8IHH-HCA2-LUF6283-Gi1/β1/γ2 8IHI-HCA2-Acifran-Gi1/β1/γ2
20.00Consensushca2_on_gpOrthosteric Ligand8J6R-HCA2-MK6892-Gi1/β1/γ2 8IHI-HCA2-Acifran-Gi1/β1/γ2 8IHH-HCA2-LUF6283-Gi1/β1/γ2 8I7V-HCA2-Acipimox-Gi1/β1/γ2 8JIM-HCA2-MMF-Gi1/β1/γ2 8I7W-HCA2-GSK256073-Gi1/β1/γ2
20.00Consensushca_on_gpOrthosteric Ligandhca2_on_gp
20.00Consensusleukotriene_onOrthosteric Ligandblt_on
20.00Consensusleukotriene_on_gpOrthosteric Ligandblt_on_gp
20.00Consensusnmur1_on_gpOrthosteric Ligand7W53-NMUR1-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
20.00Consensussst5_onOrthosteric Ligand8X8L-SST5-Cortistatin-chim(NtGi1-Gs-CtGi1)/β1/γ2 8X8N-SST5-Octreotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
19.35Single6LMLGlucagon6LML-Glucagon-Glucagon-Gi1/β1/γ1
19.35Single6UUSAdrenomedullin6UUS-CT Like (AM2)-Adrenomedullin-Gs/β1/γ2; RAMP3
19.35Single6WZGSecretin6WZG-Secretin-Secretin-Gs/β1/γ2
19.35Single7KI1Taspoglutide7KI1-GLP-1-Taspoglutide-Gs/β1/γ2
19.35Single8HAFPTHrP(1-36)8HAF-PTH1-PTHrP(1-36)-chim(NtGi1-Gs)/β1/γ2
19.35Single8KGGLPS8KGG-P2Y10-LPS-chim(NtGi2-G13)/β1/γ2
19.35Single8WWNMCH8WWN-MCH1-MCH-Gi1/β1/γ2
19.35Single8Y52BA18Y52-BB3-BA1-chim(NtGi1-Gs-CtGq)/β1/γ2
19.23Single7F1QMIP-1a7F1Q-CCR5-MIP-1a-Gi1/β1/γ2
19.23Single7VBINon-Acylated Tirzepatide7VBI-GLP-1-Non-Acylated Tirzepatide-Gs/β1/γ2
19.23Single7WJ5Somatostatin-147WJ5-SST2-Somatostatin-14-Gi1/β1/γ2
19.23Single7XNACYN1548067XNA-SST2-CYN154806
19.23Single8IEBA1LYA8IEB-GPR156-A1LYA
19.23Single8KH5Lysophosphatidylserine8KH5-GPR174-Lysophosphatidylserine-Gs/β1/γ2
19.23Single8WSSPro-MCH8WSS-MCH1-Pro-MCH-Gi1/β1/γ1
19.23Consensussst2_offOrthosteric Ligand7XNA-SST2-CYN154806
19.05Single2RH1S-Carazolol2RH1-β2-S-Carazolol
19.05Single2YCWS-Carazolol2YCW-β1-S-Carazolol
19.05Single5D6LS-Carazolol5D6L-β2-S-Carazolol
19.05Single5WQCEMPA5WQC-OX2-EMPA
19.05Single6D26Fevipiprant6D26-DP2-Fevipiprant
19.05Single6GPXMK08126GPX-CCR2-MK0812
19.05Single6HLPNetupitant6HLP-NK1-Netupitant
19.05Single6LFMInterleukin-86LFM-CXCR2-Interleukin-8-Gi1/β1/γ2
19.05Single6ME62-Phenylmelatonin6ME6-MT2-2-Phenylmelatonin
19.05Single6ME82-Phenylmelatonin6ME8-MT2-2-Phenylmelatonin
19.05Single6Z4SSR486926Z4S-NTS1-SR48692
19.05Single7SINNPS-21437SIN-CaS-NPS-2143
19.05Single7SINNPS-21437SIN-CaS-NPS-2143
19.05Single7VFXfMLF7VFX-FPR1-ALX-fMLF-Gi1/β1/γ2
19.05Single7VV0PAMP-127VV0-MRGPRX2-PAMP-12
19.05Single7W41PD1762527W41-BB2-PD176252
19.05Single7WIGL-054,2647WIG-SST2-L-054,264-Gi1/β1/γ2
19.05Single7X1TTaltirelin7X1T-TRH-Taltirelin-chim(NtGi2L-Gs-CtGq)/β1/γ2
19.05Single7Y26Octreotide7Y26-SST2-Octreotide-chim(NtGi2L-Gs-CtGq)/β1/γ2
19.05Single8C9WEtrumadenant8C9W-A2A-Etrumadenant
19.05Single8EJCTAK-8758EJC-FFA1-TAK-875-chim(NtGi1L-Gs-CtGq)/β1/γ2
19.05Single8GFYConstrained Epinephrine8GFY-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
19.05Single8GG2Constrained Epinephrine8GG2-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
19.05Single8I7WGSK2560738I7W-HCA2-GSK256073-Gi1/β1/γ2
19.05Single8JGGBAM8-228JGG-MRGPRX1-BAM8-22-Gi1/β1/γ2
19.05Single8TH4AT118-L Nanobody8TH4-AT1-Losartan-AT118-L Nanobody
19.05Single8ZPTPrRP208ZPT-PrRP-PrRP20-chim(NtGi1-Gs-CtGq)/β1/γ2
19.05Single8ZRKGSK-12922638ZRK-GPR119-GSK-1292263-Gs/β1/γ2
19.05Single9EAHOlmesartan9EAH-AT1-Olmesartan-Nanobody AT209
19.05Single9IYBProstaglandin9IYB-DP2-Prostaglandin-A1D5Q-Gi1/β1/γ2
19.05Single9MQKIsoquinuclidine9MQK-κ-Isoquinuclidine
19.05Consensusalpha_on_gpOrthosteric Ligandalpha1_on_gp alpha2_on_gp
19.05Consensusamine_offOrthosteric Ligand5ht_off adrenergic_off dopamine_off histamine_off muscarinic_off
19.05Consensusamine_offonOrthosteric Ligandamine_off amine_on
19.05Consensusamine_offon_gpOrthosteric Ligandamine_on_gp amine_off
19.05Consensusamine_onOrthosteric Ligand5ht_on adrenergic_on dopamine_on histamine_on muscarinic_on trace-amine_on
19.05Consensusbb2_offOrthosteric Ligand7W41-BB2-PD176252
19.05Consensusbeta2_offOrthosteric Ligand2RH1-β2-S-Carazolol 6PS3-β2-S-Carvedilol 6PS5-β2-S-Propranolol 3D4S-β2-Timolol 3NY8-β2-ICI118-551 3NY9-β2-ICI118-551 6PRZ-β2-S-Alprenolol
19.05Consensusbeta_offOrthosteric Ligandbeta1_off beta2_off
19.05Consensusbombesin_offOrthosteric Ligandbb2_off
19.05Consensuscxcr2_on_gpOrthosteric Ligand6LFM-CXCR2-Interleukin-8-Gi1/β1/γ2
19.05Consensusd2_onOrthosteric Ligand7JVR-D2-Bromoergocryptine-Gi1/β1/γ2 8IRS-D2-Rotigotine-Gi1/β1/γ2
19.05Consensusdp2_offOrthosteric Ligand6D26-DP2-Fevipiprant
19.05Consensusdp_offOrthosteric Liganddp2_off
19.05Consensusfpr1-alx_onOrthosteric Ligand7VFX-FPR1-ALX-fMLF-Gi1/β1/γ2
19.05Consensusfpr1-alx_on_gpOrthosteric Ligand7VFX-FPR1-ALX-fMLF-Gi1/β1/γ2
19.05Consensusgi_adrenergicOrthosteric Ligand7EJ0-α2a-L-Norepinephrine-Go/β1/γ2 7EJK-α2a-Oxymetazoline-Go/β1/γ2 7W7E-α2a-PubChem 164946676-Go/β1/γ2 7W6P-α2a-N-pyridin-4-ylisoquinolin-4-amine-Go/β1/γ2 7EJ8-α2a-Brimonidine-Go/β1/γ2 6K42-α2b-Dexmedetomidine-Gi1/β1/γ2 7EJA-α2a-Dexmedetomidine-Go/β1/γ2 7S0F-β1-Isoprenaline-Gi1/β1/γ2
19.05Consensush1_offOrthosteric Ligand8X63-H1-Mepyramine 3RZE-H1-Cidoxepin 8X5Y-H1-Astemizole
19.05Consensusta1_onOrthosteric Ligand8W87-TA1-METH-chim(NtGi1L-Gs)/β1/γ2 8W89-TA1-PEA-chim(NtGi1L-Gs)/β1/γ2 8JLP-TA1-Ralmitaront-Gs/β1/γ2 8W8A-TA1-RO5256390-chim(NtGi1L-Gs)/β1/γ2 8W88-TA1-SEP-363856-Gs/β1/γ2 8JLO-TA1-Ulotaront-Gs/β1/γ2 8JLR-TA1-A77636-chim(NtGi1-Gs)/β1/γ2 8JSO-TA1-AMPH-chim(NtGi1-Gs)/β1/γ2 8ZSP-TA1-LSD-chim(NtGi1L-Gs-CtGq)/β1/γ2
19.05Consensustrace-amine_onOrthosteric Ligandta1_on
18.75Single3OE8IT1t3OE8-CXCR4-IT1t
18.75Single6XBM25(S)-Epoxycholesterol6XBM-SMO-25(S)-Epoxycholesterol-Gi1/β1/γ2
18.75Single7DUQGLP-17DUQ-GLP-1-GLP-1-PubChem 156022738-Gs/β1/γ2
18.75Single9C2FCa; Ca; Tryptophan; '6218; PO49C2F-CaS-Ca-Ca; Ca; Tryptophan; '6218; PO4
18.75Consensusp2y_offOrthosteric Ligandp2y1_off
18.52Single6UUNAdrenomedullin6UUN-CT Like (AM1)-Adrenomedullin-Gs/β1/γ2; RAMP2
18.52Single7F4DAlpha-MSH7F4D-MC1-α-MSH-chim(NtGi1-Gs)/β1/γ2
18.52Single8XZHMM078XZH-Apelin-MM07-Gi1/β1/γ2
18.52Consensuscckb_on_gpOrthosteric Ligand8IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/β1/γ2 7XOW-CCKB-Gastrin-chim(NtGi1-Gq)/β1/γ2 7F8V-CCKB-Gastrin-17-Gi2/β1/γ2
18.52Consensusmc3_onOrthosteric Ligand8IOC-MC3-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
18.52Consensusmc3_on_gpOrthosteric Ligand8IOC-MC3-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
18.18Single5D5AS-Carazolol5D5A-β2-S-Carazolol
18.18Single5D5BS-Carazolol5D5B-β2-S-Carazolol
18.18Single5ZHPPubChem 1348285895ZHP-M3-PubChem 134828589
18.18Single5ZKBAF-DX 3845ZKB-M2-AF-DX 384
18.18Single6E59L-7607356E59-NK1-L-760735
18.18Single6J20Aprepitant6J20-NK1-Aprepitant
18.18Single6KO5PubChem 574000026KO5-Ghrelin-PubChem 57400002
18.18Single6TQ7SB-3348676TQ7-OX1-SB-334867
18.18Single7B6WCyclazosin7B6W-α1b-Cyclazosin
18.18Single7E2ZAripiprazole7E2Z-5-HT1A-Aripiprazole-Gi1/β1/γ2
18.18Single7VBHPeptide-207VBH-GLP-1-Peptide-20-Gs/β1/γ2
18.18Single7W6PN-pyridin-4-ylisoquinolin-4-amine7W6P-α2a-N-pyridin-4-ylisoquinolin-4-amine-Go/β1/γ2
18.18Single7W7EPubChem 1649466767W7E-α2a-PubChem 164946676-Go/β1/γ2
18.18Single7XJLSpexin7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/β1/γ2
18.18Single7XWONeurokinin-A7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
18.18Single8FLULong-Acting PTH8FLU-PTH1-Long-Acting PTH-Gs/β1/γ2
18.18Single8IYHMK68928IYH-HCA2-MK6892-Go/β1/γ2
18.18Single8JGFBAM8-228JGF-MRGPRX1-BAM8-22-chim(NtGi1-Gs-CtGq)/β1/γ2
18.18Single8JLPRalmitaront8JLP-TA1-Ralmitaront-Gs/β1/γ2
18.18Single8JT6(R)-IHCH-71798JT6-5-HT1A-(R)-IHCH-7179-Gi1/β1/γ2
18.18Single8JXWVUF68848JXW-H4-VUF6884-Gi1/β1/γ2
18.18Single8JXXClobenpropit8JXX-H4-Clobenpropit-Gi1/β1/γ2
18.18Single8XIPPasireotide8XIP-SST1-Pasireotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
18.18Single8XX7CXCL58XX7-CXCR2-CXCL5-Go/β1/γ2
18.18Single9ASTLymphotactin9AST-XCR1-Lymphotactin-Gi1/β1/γ2
18.18Single9BJKNAM9BJK-μ-Naloxone-NAM
18.18Consensusamine_on_gpOrthosteric Ligand5ht_on_gp adrenergic_on_gp dopamine_on_gp histamine_on_gp muscarinic_on_gp trace-amine_on_gp
18.18Consensusbeta1_offOrthosteric Ligand2VT4-β1-Cyanopindolol 2YCW-β1-S-Carazolol 2YCZ-β1-Iodocyanopindolol 5A8E-β1-7-Methylcyanopindolol-Na 3ZPQ-β1-4-(piperazin-1- yl)-1H-indole-Na 3ZPR-β1-4-methyl-2-(piperazin-1-yl)-Na
18.18Consensusffa2_onOrthosteric Ligand8J22-FFA2-TUG-1375-Gi1/β1/γ2
18.18Consensusgi_5htOrthosteric Ligand8FYT-5-HT1A-LSD-Gi1/β1/γ1 7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/β1/γ2 8UGY-5-HT1E-Mianserin-Gi1/β1/γ1 8W8B-5-HT1A-SEP-363856-Gi1/β1/γ2 7E2Y-5-HT1A-Serotonin-Gi1/β1/γ2 7E32-5-HT1D-Serotonin-Gi1/β1/γ2 7XTA-5-HT4-Serotonin-Gi1/β1/γ2 8UH3-5-HT1E-Setiptiline-Gi1/β1/γ1 8JSP-5-HT1A-Ulotaront-Gi1/β1/γ2 8FYL-5-HT1A-Vilazodone-Gi1/β1/γ1 8JT6-5-HT1A-(R)-IHCH-7179-Gi1/β1/γ2 8FYE-5-HT1A-4-F,5-MeO-PyrT-Gi1/β1/γ1 7X5H-5-HT5A-5-CT-Gi1/β1/γ2 8FY8-5-HT1A-5-MeO-DMT-Gi1/β1/γ1 7E2Z-5-HT1A-Aripiprazole-Gi1/β1/γ2 7E33-5-HT1E-BRL-54443-Gi1/β1/γ2 8FYX-5-HT1A-Buspirone-Gi1/β1/γ1 7EXD-5-HT1F-Lasmiditan-Gi1/β1/γ2 7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/β1/γ2
18.18Consensusnk2_on_gpOrthosteric Ligand7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
18.18Consensusnpy_offOrthosteric Ligandnpy1_off npy2_off
18.18Consensusta1_on_gpOrthosteric Ligand8W87-TA1-METH-chim(NtGi1L-Gs)/β1/γ2 8W89-TA1-PEA-chim(NtGi1L-Gs)/β1/γ2 8JLP-TA1-Ralmitaront-Gs/β1/γ2 8W8A-TA1-RO5256390-chim(NtGi1L-Gs)/β1/γ2 8W88-TA1-SEP-363856-Gs/β1/γ2 8JLO-TA1-Ulotaront-Gs/β1/γ2 8JLR-TA1-A77636-chim(NtGi1-Gs)/β1/γ2 8JSO-TA1-AMPH-chim(NtGi1-Gs)/β1/γ2 8ZSP-TA1-LSD-chim(NtGi1L-Gs-CtGq)/β1/γ2
18.18Consensustachykinin_offOrthosteric Ligandnk1_off
18.18Consensustrace-amine_on_gpOrthosteric Ligandta1_on_gp
17.86Single6M1IPACAP6M1I-PAC1-PACAP-Gs/β1/γ2
17.86Single6WIVPubChem 52923113; PubChem 529246456WIV-GABAB1, GABAB2-PubChem 52923113; PubChem 52924645
17.86Single7TYIAmylin7TYI-CT-Amylin-Gs/β1/γ2
17.86Single7V9MSomatoliberin7V9M-GHRH (SV1)-Somatoliberin-Gs/β1/γ2
17.86Single7XK8Neuromedin-U-257XK8-NMUR2-Neuromedin-U-25-Gi1/β1/γ2
17.86Single8HA0PTH8HA0-PTH1-PTH-chim(NtGi1-Gs)/β1/γ2
17.86Single8IEDA1LYA8IED-GPR156-A1LYA-Go/β1/γ2
17.86Single8YW3Retatrutide8YW3-GLP-1-Retatrutide-Gs/β1/γ2
17.86Consensusapelin_onOrthosteric Ligand8XZH-Apelin-MM07-Gi1/β1/γ2 7W0M-Apelin-PubChem 122701908-Gi1/β1/γ2 8XZJ-Apelin-WN353-Gi1/β1/γ2 8XZF-Apelin-WN561-Gi1/β1/γ2 8XZG-Apelin-Apelin-13-Gi1/β1/γ2
17.86Consensusapelin_on_gpOrthosteric Ligand8XZH-Apelin-MM07-Gi1/β1/γ2 7W0M-Apelin-PubChem 122701908-Gi1/β1/γ2 8XZJ-Apelin-WN353-Gi1/β1/γ2 8XZF-Apelin-WN561-Gi1/β1/γ2 8XZG-Apelin-Apelin-13-Gi1/β1/γ2
17.65Single2J4Y11-cis-Retinal2J4Y-Rhodopsin-11-cis-Retinal
17.65Single3OE6IT1t3OE6-CXCR4-IT1t
17.65Single3UZAGTPL92363UZA-A2A-GTPL9236
17.65Single4XNWMRS25004XNW-P2Y1-MRS2500
17.65Single5WKTOctyl-Beta-D-Glucopyranoside5WKT-Rhodopsin-Octyl-β-D-Glucopyranoside-Gt(CT)
17.65Single6FK9PubChem 1324730366FK9-Rhodopsin-PubChem 132473036
17.65Single6ME5Agomelatine6ME5-MT1-Agomelatine
17.65Single6WPWGlucagon derivative ZP37806WPW-Glucagon-Glucagon derivative ZP3780-Gs/β1/γ2
17.65Single7EJKOxymetazoline7EJK-α2a-Oxymetazoline-Go/β1/γ2
17.65Single7V35Peptide-207V35-Glucagon-Peptide-20-Gs/β1/γ2
17.65Single8F76Propanoic acid8F76-OR51E2-Propanoic acid-Gs/β1/γ2
17.65Single8GGFConstrained Epinephrine8GGF-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
17.65Single8J6QBeta-Hydroxybutyrate8J6Q-HCA2-β-Hydroxybutyrate-Compound 9n-Gi1/β1/γ2
17.65Single8JEF(3S)-3-hydroxyoctanoic acid8JEF-HCA3-(3S)-3-hydroxyoctanoic acid-Gi1/β1/γ2
17.65Single8JIPMEDI03828JIP-GLP-1-MEDI0382-chim(NtGi1-Gs)/β1/γ2
17.65Single8JIRSAR4258998JIR-GLP-1-SAR425899-chim(NtGi1-Gs)/β1/γ2
17.65Single8JRVGlucagon8JRV-Glucagon-Glucagon-Arrestin2
17.65Single8RQLFlufenamic acid8RQL-TAS2R14-Flufenamic acid-Flufenamic acid-chim(NtGi1-Gt3)/β1/γ2
17.65Single8X9UMetenolone8X9U-ADGRD1-Metenolone-chim(NtGi1-Gs)/β1/γ2
17.65Single9C1PCa; Tryptophan; '6218; PO49C1P-CaS-Ca-Ca; Tryptophan; '6218; PO4
17.65Single9IV15alpha-DHT9IV1-ADGRD1-5α-DHT-chim(NtGi1-Gs)/β1/γ2
17.65Consensus5ht2_onOrthosteric Ligand5ht2b_on
17.65Consensus5ht2b_onOrthosteric Ligand7SRR-5-HT2B-LSD-chim(NtGi2L-Gs-CtGq)/β1/γ2
17.65Consensusp2y1_offOrthosteric Ligand4XNW-P2Y1-MRS2500
17.39Single3D4STimolol3D4S-β2-Timolol
17.39Single3VW7Vorapaxar; Na3VW7-PAR1-Vorapaxar; Na
17.39Single4N4WSANT-14N4W-SMO-SANT-1
17.39Single6A93Risperidone6A93-5-HT2A-Risperidone
17.39Single6W2YPubChem 237279706W2Y-GABAB1; GABAB1-PubChem 5311042-PubChem 23727970
17.39Single6XBLCholesterol6XBL-SMO-SAG-Cholesterol-Gi1/β1/γ2
17.39Single6XOXOrforglipron6XOX-GLP-1-Orforglipron-chim(NtGi1-Gs)/β1/γ2
17.39Single6ZG4HTL00099366ZG4-M1-HTL0009936
17.39Single7EPENAM5637EPE-mGlu2; mGlu2-NAM563
17.39Single7JNIOlodanrigan7JNI-AT2-Olodanrigan
17.39Single7WCMMBX-29827WCM-GPR119-MBX-2982-Gs/β1/γ2
17.39Single7XJKGalanin7XJK-GAL2-Galanin-chim(NtGi2L-Gs-CtGq)/β1/γ2
17.39Single7XW6ML1097XW6-TSH-M22 Fab-ML109-Gs/β1/γ2
17.39Single7XW9TRH7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/β1/γ2
17.39Single8DWCProenkephalin-A8DWC-MRGPRX1-Proenkephalin-A-chim(NtGi2L-Gs-CtGq)/β1/γ2
17.39Single8FYE4-F,5-MeO-PyrT8FYE-5-HT1A-4-F,5-MeO-PyrT-Gi1/β1/γ1
17.39Single8H0QGastrin Releasing Peptide8H0Q-BB2-Gastrin Releasing Peptide-chim(NtGi1-Gs-CtGq)/β1/γ2
17.39Single8JD3HZR; PEF8JD3-mGlu2; mGlu3-Glutamate-HZR; PEF-Gi1/β1/γ2
17.39Single8JJPChemerin8JJP-CML2-Chemerin-Gi1/β1/γ2
17.39Single8X8NOctreotide8X8N-SST5-Octreotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
17.39Single8XQNCholesterol8XQN-TAS2R14-Cholesterol-Aristolochic acid A-Gi1/β1/γ1
17.39Single8XWACXCL18XWA-CXCR2-CXCL1
17.39Single8XWMCXCL68XWM-CXCR2-CXCL6
17.39Single8XWSCXCL58XWS-CXCR2-CXCL5
17.39Single8XYIVUF106618XYI-CXCR3-VUF10661
17.39Consensusgi_amineOrthosteric Ligandgi_5ht gi_muscarinic gi_adrenergic gi_dopamine gi_histamine
17.39Consensusnk1_offOrthosteric Ligand6HLP-NK1-Netupitant 6HLO-NK1-Aprepitant 6HLL-NK1-CP99994 6E59-NK1-L-760735
17.39Consensustrh_onOrthosteric Ligand7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/β1/γ2
17.39Consensustrh_on_gpOrthosteric Ligand7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/β1/γ2
17.24Single7LLYOxyntomodulin7LLY-GLP-1-Oxyntomodulin-Gs/β1/γ2
17.24Single7QBIAlpha-factor mating pheromone7QBI-STE2-α-factor mating pheromone
17.24Single7XV3Lysophosphatidylserine7XV3-GPR174-Lysophosphatidylserine-chim(NtGi1-Gs)/β1/γ2
17.24Single8HNKCXCL118HNK-CXCR3-CXCL11-Gi1/β1/γ2
17.24Consensusneuromedin-u_on_gpOrthosteric Ligandnmur1_on_gp nmur2_on_gp
17.24Consensusp2y10_onOrthosteric Ligand8KGG-P2Y10-LPS-chim(NtGi2-G13)/β1/γ2
17.14Single7Y36Teriparatide7Y36-PTH1-Teriparatide-Gs/β1/γ2
17.14Single8FLQPTH8FLQ-PTH1-PTH-Gs/β1/γ2
17.14Single8JIUSAR4258998JIU-Glucagon-SAR425899-Gs/β1/γ2
17.14Single9JR3PTH9JR3-PTH1-PTH-chim(NtGi1L-Gs-CtGq)/β1/γ2
16.67Single3OE9IT1t3OE9-CXCR4-IT1t
16.67Single3PBLEticlopride3PBL-D3-Eticlopride
16.67Single5L7IVismodegib5L7I-SMO-Vismodegib
16.67Single5UNGPubChem 157800525UNG-AT2-PubChem 15780052
16.67Single6BQHRitanserin6BQH-5-HT2C-Ritanserin
16.67Single6E3YCalcitonin gene-related peptide-16E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/β1/γ2; RAMP1
16.67Single6FK6PubChem 1324730336FK6-Rhodopsin-PubChem 132473033
16.67Single6I9K9-cis-Retinal6I9K-Rhodopsin-9-cis-Retinal
16.67Single6M1HMaxadilan6M1H-PAC1-Maxadilan-Gs/β1/γ2
16.67Single6NBFLong-Acting PTH Analog6NBF-PTH1-Long-Acting PTH Analog-Gs/β1/γ2
16.67Single6PGSGeraniol6PGS-Rhodopsin-Geraniol-Gt(CT)
16.67Single7D3SSecretin7D3S-Secretin-Secretin-Gs/β1/γ2
16.67Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
16.67Single7EZHCholecystokinin-87EZH-CCKA-Cholecystokinin-8-Gi1/β1/γ2
16.67Single7EZMCholecystokinin-87EZM-CCKA-Cholecystokinin-8-chim(NtGsL-Gq)/β1/γ2
16.67Single7F8VGastrin-177F8V-CCKB-Gastrin-17-Gi2/β1/γ2
16.67Single7KI0Semaglutide7KI0-GLP-1-Semaglutide-Gs/β1/γ2
16.67Single7MBYCholecystokinin-87MBY-CCKA-Cholecystokinin-8-chim(NtGi1L-Gs-CtGq)/β1/γ2
16.67Single7PIUSetmelanotide7PIU-MC4-Setmelanotide-Gs/β1/γ2
16.67Single7QBIAlpha-factor mating pheromone7QBI-STE2-α-factor mating pheromone
16.67Single7QVMOxytocin7QVM-OT-Oxytocin-chim(NtGi1-Go-CtGq)/β1/γ2
16.67Single7S8NR-Zinc-35737S8N-MRGPRX2-R-Zinc-3573-chim(NtGi2L-Gs-CtGq)/β1/γ2
16.67Single7S8OR-Zinc-35737S8O-MRGPRX2-R-Zinc-3573-Gi1/β1/γ2
16.67Single7SK7CCX6627SK7-ACKR3-CXCL12-CCX662
16.67Single7SK8CCX6627SK8-ACKR3-CXCL12-CCX662
16.67Single7SRQLSD7SRQ-5-HT2B-LSD
16.67Single7TRPLY20332987TRP-M4-Iperoxo-LY2033298-Gi1/β1/γ2
16.67Single7U2KC6-guano7U2K-μ-C6-guano-Gi1/β1/γ2
16.67Single7VGY2-Iodomelatonin7VGY-MT1-2-Iodomelatonin-Gi1/β1/γ2
16.67Single7XP6Strychnine7XP6-T2R46-Strychnine-chim(Gs-CtGt3)/β1/γ2
16.67Single7XT9Serotonin7XT9-5-HT4-Serotonin-Gs/β1/γ2
16.67Single7XTBSerotonin7XTB-5-HT6-Serotonin-Gs/β1/γ2
16.67Single8A2PLUAA470708A2P-A2A-LUAA47070-Na
16.67Single8FLRPTHrP(1-36)8FLR-PTH1-PTHrP(1-36)-Gs/β1/γ2
16.67Single8GGYConstrained Epinephrine8GGY-β2-Constrained Epinephrine
16.67Single8HN1Toxin AdTx18HN1-Alpha1A-Toxin AdTx1
16.67Single8IHIAcifran8IHI-HCA2-Acifran-Gi1/β1/γ2
16.67Single8J19LY2378J19-GPR84-LY237-Gi1/β1/γ2
16.67Single8JLOUlotaront8JLO-TA1-Ulotaront-Gs/β1/γ2
16.67Single8JPNCis-Epoxysuccinic acid8JPN-Succinate-Cis-Epoxysuccinic acid-Gi1/β1/γ1
16.67Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
16.67Single8U4RREGN7663-Fab8U4R-CXCR4-REGN7663-Fab-Cholesterol
16.67Single8UO4Constrained Epinephrine8UO4-β2-Constrained Epinephrine-GTP; Mg-Gs/β1/γ2
16.67Single8WP1Cis-Epoxysuccinic acid8WP1-Succinate-Cis-Epoxysuccinic acid-Gi1/β1/γ2
16.67Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/β1/γ2
16.67Single8XIOL7975918XIO-SST1-L797591-chim(NtGi1-Gs-CtGi1)/β1/γ2
16.67Single8XVJMacitentan8XVJ-ETA-Macitentan
16.67Single8XWVCXCL18XWV-CXCR2-CXCL1-Go/β1/γ2
16.67Single8YKWSuccinic acid8YKW-Succinate-Succinic acid-Gi1/β1/γ1
16.67Single8YN4Histamine8YN4-H2-Histamine-chim(NtGi1L-Gs-CtGq)/β1/γ2
16.67Single8ZSVRO52633978ZSV-TA1-RO5263397-chim(NtGi1-Gs)/β1/γ2
16.67Single8ZX5AM2518ZX5-GPR55-AM251-chim(NtGi1-G13)/β1/γ2
16.67Single9B9Y7DY9B9Y-CB1-7DY
16.67Single9EAILosartan9EAI-AT1-Losartan-Nanobody AT209
16.67Single9IJEEpinephrine9IJE-β3-Epinephrine-chim(NtGi1-Gs)/β1/γ2
16.67Consensus5ht2c_offOrthosteric Ligand6BQH-5-HT2C-Ritanserin
16.67Consensuscck_onOrthosteric Ligandccka_on cckb_on
16.67Consensuscck_on_gpOrthosteric Ligandccka_on_gp cckb_on_gp
16.67Consensusccka_onOrthosteric Ligand7EZH-CCKA-Cholecystokinin-8-Gi1/β1/γ2
16.67Consensusccka_on_gpOrthosteric Ligand7EZH-CCKA-Cholecystokinin-8-Gi1/β1/γ2
16.67Consensuschemerin_onOrthosteric Ligandcml1_on
16.67Consensusd3_offOrthosteric Ligand3PBL-D3-Eticlopride
16.67Consensusgal2_onOrthosteric Ligand7WQ4-GAL2-Galanin-chim(NtGi1-Gs-CtGq)/β1/γ2 7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/β1/γ2
16.67Consensusgal2_on_gpOrthosteric Ligand7WQ4-GAL2-Galanin-chim(NtGi1-Gs-CtGq)/β1/γ2 7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/β1/γ2
16.67Consensusnk2_onOrthosteric Ligand7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
16.67Consensusprostanoid_offOrthosteric Ligandep_off dp_off
16.13Single6P9XCorticoliberin6P9X-CRF1-Corticoliberin-Gs/β1/γ2
16.13Single7AD3Alpha-factor mating pheromone7AD3-STE2-α-factor mating pheromone-Gi1/STE4/γ2
16.13Single7EIBDes-Arg10-Kallidin7EIB-BK1-Des-Arg10-Kallidin-chim(NtGi1-Gs-CtGq)/β1/γ2
16.13Single7QBCAlpha-factor mating pheromone7QBC-STE2-α-factor mating pheromone
16.13Single7VVKPTH7VVK-PTH1-PTH-Gs/β1/γ2
16.13Single8HAOPTH8HAO-PTH1-PTH-chim(NtGi1-Gs)/β1/γ2
16.13Consensusp2y10_on_gpOrthosteric Ligand8KGG-P2Y10-LPS-chim(NtGi2-G13)/β1/γ2
16.00Single6KNMJN241-96KNM-Apelin-JN241-9
16.00Single7XN9L-054,5227XN9-SST2-L-054,522
16.00Single8XQOCholesterol8XQO-TAS2R14-Cholesterol-Aristolochic acid A-Gi1/β1/γ1
16.00Single9ITBLPA9ITB-LPA6-LPA-chim(NtGi1-Gs-CtGq)/β1/γ2
15.79Single1GZM11-cis-Retinal1GZM-Rhodopsin-11-cis-Retinal
15.79Single3C9L11-cis-Retinal3C9L-Rhodopsin-11-cis-Retinal
15.79Single3ODUIT1t3ODU-CXCR4-IT1t
15.79Single4MQTLY21196204MQT-M2-Iperoxo-LY2119620
15.79Single4S0VSuvorexant4S0V-OX2-Suvorexant
15.79Single5OLVLUAA410635OLV-A2A-LUAA41063-Na
15.79Single5U09Taranabant5U09-CB1-Taranabant
15.79Single5ZKQABT-4915ZKQ-PAF-ABT-491
15.79Single6AKYMaraviroc6AKY-CCR5-Maraviroc
15.79Single6D9HAdenosine6D9H-A1-Adenosine-Gi2/β1/γ2
15.79Single6LFOInterleukin-86LFO-CXCR2-Interleukin-8-Gi1/β1/γ2
15.79Single6ME2Ramelteon6ME2-MT1-Ramelteon
15.79Single6ME9Ramelteon6ME9-MT2-Ramelteon
15.79Single6RNKNF-56-EJ406RNK-Succinate-NF-56-EJ40
15.79Single6TPJSuvorexant6TPJ-OX2-Suvorexant
15.79Single6WWZCCL206WWZ-CCR6-CCL20-Go/β1/γ2
15.79Single7BR3Elagolix7BR3-GnRH1-Elagolix
15.79Single7DHRIsoprenaline7DHR-β2-Isoprenaline-Gs/β1/γ2
15.79Single7EJ0L-Norepinephrine7EJ0-α2a-L-Norepinephrine-Go/β1/γ2
15.79Single7F8ULintitript7F8U-CCKA-Lintitript
15.79Single7F8YDevazepide7F8Y-CCKA-Devazepide
15.79Single7LCJDanuglipron7LCJ-GLP-1-Danuglipron
15.79Single7M3ECa; Ca; Tryptophan; NPS-21437M3E-CaS-Ca; Ca; Tryptophan; NPS-2143
15.79Single7M3ECa; Ca; Tryptophan; NPS-21437M3E-CaS-Ca; Ca; Tryptophan; NPS-2143
15.79Single7S8PMS471347S8P-MRGPRX4-MS47134-chim(NtGi2L-Gs-CtGq)/β1/γ2
15.79Single7T6SPubChem 247763417T6S-FPR2-ALX-PubChem 24776341-Gi1/β1/γ2
15.79Single7W0MPubChem 1227019087W0M-Apelin-PubChem 122701908-Gi1/β1/γ2
15.79Single7W0OElabela7W0O-Apelin-Elabela-Gi1/β1/γ2
15.79Single7X2FDopamine7X2F-D1-Dopamine-Mevidalen-Gs/β1/γ2
15.79Single7X5H5-CT7X5H-5-HT5A-5-CT-Gi1/β1/γ2
15.79Single7XJJGalanin7XJJ-GAL1-Galanin-Go/β1/γ2
15.79Single7XT8Serotonin7XT8-5-HT4-Serotonin-Gs/β1/γ2
15.79Single7YMHNorepinephrine7YMH-Alpha1A-Norepinephrine-chim(Gs-CtGq)
15.79Single8DWGML3828DWG-MRGPRX1-Proenkephalin-A-ML382-chim(NtGi2L-Gs-CtGq)/β1/γ2
15.79Single8DWHPubChem 1390305318DWH-MRGPRX1-PubChem 139030531-chim(NtGi2L-Gs-CtGq)/β1/γ2
15.79Single8FYXBuspirone8FYX-5-HT1A-Buspirone-Gi1/β1/γ1
15.79Single8GGAConstrained Epinephrine8GGA-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
15.79Single8GGRConstrained Epinephrine8GGR-β2-Constrained Epinephrine
15.79Single8GGWConstrained Epinephrine8GGW-β2-Constrained Epinephrine
15.79Single8GH0Constrained Epinephrine8GH0-β2-Constrained Epinephrine
15.79Single8IJBAcipimox8IJB-HCA2-Acipimox-Gi1/β1/γ2
15.79Single8J6LNiacin8J6L-HCA2-Niacin-Gi1/β1/γ2
15.79Single8TZQL-Dopamine8TZQ-D2-L-Dopamine-Go/β1/γ2
15.79Single8UNSConstrained Epinephrine8UNS-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
15.79Single8UNTConstrained Epinephrine8UNT-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
15.79Single8UNXConstrained Epinephrine8UNX-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
15.79Single8UTDMK19038UTD-HCA2-MK1903-Gi1/β1/γ2
15.79Single8WOGSuccinic acid8WOG-Succinate-Succinic acid-Gi1/β1/γ2
15.79Single8XXXCXCL68XXX-CXCR2-CXCL6-Go/β1/γ2
15.79Single8YKXMaleic acid8YKX-Succinate-Maleic acid-Gi1/β1/γ1
15.79Single8YUTAmthamine8YUT-H2-Amthamine-Gs/β1/γ2
15.79Single9AVLCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVL-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi3/β2/γ2
15.79Single9MQJIsoquinuclidine9MQJ-μ-Isoquinuclidine
15.79Consensus5ht1e_onOrthosteric Ligand7E33-5-HT1E-BRL-54443-Gi1/β1/γ2 8UGY-5-HT1E-Mianserin-Gi1/β1/γ1 8UH3-5-HT1E-Setiptiline-Gi1/β1/γ1
15.79Consensus5ht_onOrthosteric Ligand5ht1_on 5ht2_on 5ht4_on 5ht5_on 5ht6_on 5ht7_on
15.79Consensusalpha2_offOrthosteric Ligandalpha2c_off
15.79Consensusccr6_onOrthosteric Ligand6WWZ-CCR6-CCL20-Go/β1/γ2
15.79Consensusccr6_on_gpOrthosteric Ligand6WWZ-CCR6-CCL20-Go/β1/γ2
15.79Consensusgi_succinateOrthosteric Ligand8YKW-Succinate-Succinic acid-Gi1/β1/γ1 8YKX-Succinate-Maleic acid-Gi1/β1/γ1
15.79Consensusgnrh1_offOrthosteric Ligand7BR3-GnRH1-Elagolix
15.79Consensusgs_5htOrthosteric Ligand7XTC-5-HT7-5-CT-Gs/β1/γ2 7XTB-5-HT6-Serotonin-Gs/β1/γ2 8JLZ-5-HT6-ST1936-Gs/β1/γ2 7XT8-5-HT4-Serotonin-Gs/β1/γ2
15.79Consensusp2y1_onOrthosteric Ligand7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/β1/γ2
15.79Consensuspaf_offOrthosteric Ligand5ZKQ-PAF-ABT-491
15.79Consensussuccinate_onOrthosteric Ligand8YKW-Succinate-Succinic acid-Gi1/β1/γ1 8YKX-Succinate-Maleic acid-Gi1/β1/γ1
15.79Consensussuccinate_on_gpOrthosteric Ligand8YKW-Succinate-Succinic acid-Gi1/β1/γ1 8YKX-Succinate-Maleic acid-Gi1/β1/γ1
15.62Single6NBHLong-Acting PTH Analog6NBH-PTH1-Long-Acting PTH Analog-Gs/β1/γ2
15.62Single6PB1Urocortin6PB1-CRF2-Urocortin-chim(NtGi1-Gs)/β1/γ2
15.62Single7D68GLP-27D68-GLP-2-GLP-2-Gs/β1/γ2
15.62Single7QBCAlpha-factor mating pheromone7QBC-STE2-α-factor mating pheromone
15.62Single7TYLAmylin7TYL-CT-Amylin-Gs/β1/γ2
15.62Single7VVJPTHrP(1-36)7VVJ-PTH1-PTHrP(1-36)-Gs/β1/γ2
15.62Single7VVLPTH7VVL-PTH1-PTH-Gs/β1/γ2
15.62Single8F0KPramlintide Analogue San3858F0K-CT (AMY3)-Pramlintide Analogue San385-Gs/β1/γ2; RAMP3
15.38Single5UNFPubChem 157800525UNF-AT2-PubChem 15780052
15.38Single6X19CHU-1286X19-GLP-1-CHU-128-Gs/β1/γ2
15.38Single7RTBPeptide-197RTB-GLP-1-Peptide-19-Gs/β1/γ2
15.38Single7VLACCL15(27-92)7VLA-CCR1-CCL15(27-92)-Gi1/β1/γ2
15.38Single7WICSomatostatin-147WIC-SST2-Somatostatin-14-Gi1/β1/γ2
15.38Single7WVWfMYFINILTL7WVW-FPR2-ALX-fMYFINILTL-Gi2/β1/γ2
15.38Single8FYLVilazodone8FYL-5-HT1A-Vilazodone-Gi1/β1/γ1
15.38Single8IEIA1LYA8IEI-GPR156-A1LYA
15.38Single8JIQPeptide-158JIQ-Glucagon-Peptide-15-Gs/β1/γ2
15.38Single8KIGSHU91198KIG-MC3-SHU9119-Ca
15.38Single8ZCJPasireotide8ZCJ-SST5-Pasireotide-Gi1/β1/γ1
15.38Consensusccr1_onOrthosteric Ligand7VLA-CCR1-CCL15(27-92)-Gi1/β1/γ2
15.38Consensusccr1_on_gpOrthosteric Ligand7VLA-CCR1-CCL15(27-92)-Gi1/β1/γ2
15.38Consensussomatostatin_offOrthosteric Ligandsst2_off
15.15Single7RBTTirzepatide7RBT-GIP-Tirzepatide-PubChem 163183774-chim(NtGi1-Gs)/β1/γ2
15.15Single7TYXAmylin7TYX-CT (AMY2)-Amylin-Gs/β1/γ2; RAMP2
15.00Single2YDOAdenosine2YDO-A2A-Adenosine
15.00Single3OAX11-cis-Retinal3OAX-Rhodopsin-11-cis-Retinal
15.00Single4ZUDOlmesartan4ZUD-AT1-Olmesartan
15.00Single6FKAPubChem 1324730376FKA-Rhodopsin-PubChem 132473037
15.00Single6K41Dexmedetomidine6K41-α2b-Dexmedetomidine-Go/β1/γ2
15.00Single6ME42-Iodomelatonin6ME4-MT1-2-Iodomelatonin
15.00Single6TPKRetosiban6TPK-OT-Retosiban
15.00Single6U1NLY21196206U1N-M2-LY2119620-Arrestin2
15.00Single6ZDVChromone 5d6ZDV-A2A-Chromone 5d-Na
15.00Single6ZFZ77-LH-28-16ZFZ-M1-77-LH-28-1
15.00Single6ZG9GSK10347026ZG9-M1-GSK1034702
15.00Single6ZINSR486926ZIN-NTS1-SR48692
15.00Single7BB6AVP7BB6-V2-AVP-Gs/β1/γ2
15.00Single7CMVPD1289077CMV-D3-PD128907-Gi1/β1/γ2
15.00Single7DHISalbutamol7DHI-β2-Salbutamol-Gs/β1/γ2
15.00Single7E33BRL-544437E33-5-HT1E-BRL-54443-Gi1/β1/γ2
15.00Single7F24Dopamine7F24-D1-Dopamine-GDP-Gs/β1/γ2
15.00Single7UL3Famotidine7UL3-H2-Famotidine
15.00Single7UTZPubChem 6440787UTZ-TSH-TR1402-PubChem 644078-Gs/β1/γ2
15.00Single7VUGJNJ-635330547VUG-GPR139-JNJ-63533054-Gi1/β1/γ2
15.00Single7WC9PubChem 1624213647WC9-5-HT2A-PubChem 162421364
15.00Single7WVUfMLF7WVU-FPR1-ALX-fMLF-Gi1/β1/γ2
15.00Single7XOVSR1461317XOV-CCKA-SR146131-Gs/β1/γ2
15.00Single7ZBC11-cis-Retinal7ZBC-Rhodopsin-11-cis-Retinal
15.00Single7ZBE11-cis-Retinal7ZBE-Rhodopsin-11-cis-Retinal
15.00Single8FCZ11-cis-Retinal8FCZ-Rhodopsin-11-cis-Retinal
15.00Single8GE1Constrained Epinephrine8GE1-β2-Constrained Epinephrine-Gs/β1/γ2
15.00Single8GE4Constrained Epinephrine8GE4-β2-Constrained Epinephrine-Gs/β1/γ2
15.00Single8GE6Constrained Epinephrine8GE6-β2-Constrained Epinephrine-Gs/β1/γ2
15.00Single8GE7Constrained Epinephrine8GE7-β2-Constrained Epinephrine-Gs/β1/γ2
15.00Single8GE8Constrained Epinephrine8GE8-β2-Constrained Epinephrine-Gs/β1/γ2
15.00Single8GEAConstrained Epinephrine8GEA-β2-Constrained Epinephrine-Gs/β1/γ2
15.00Single8GEDConstrained Epinephrine8GED-β2-Constrained Epinephrine-Gs/β1/γ2
15.00Single8GEFConstrained Epinephrine8GEF-β2-Constrained Epinephrine-Gs/β1/γ2
15.00Single8GG8Constrained Epinephrine8GG8-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
15.00Single8GGVConstrained Epinephrine8GGV-β2-Constrained Epinephrine
15.00Single8HJ5PubChem 1390305318HJ5-MRGPRX1-PubChem 139030531-chim(NtGi1-Gs-CtGq)/β1/γ2
15.00Single8JIMMMF8JIM-HCA2-MMF-Gi1/β1/γ2
15.00Single8JLKUlotaront8JLK-TA1-Ulotaront-chim(NtGi1-Gs)/β1/γ2
15.00Single8THKA616038THK-Alpha1A-A61603-chim(NtGi2L-Gs-CtGq)/β1/γ2
15.00Single8U02L-Dopamine8U02-D2-L-Dopamine-Go/β1/γ2
15.00Single8UNMConstrained Epinephrine8UNM-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
15.00Single8UNWConstrained Epinephrine8UNW-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
15.00Single8V6UPubChem 1713924568V6U-5-HT2A-PubChem 171392456-chim(NtGi2-Gs-CtGq)/β1/γ2
15.00Single8W88SEP-3638568W88-TA1-SEP-363856-Gs/β1/γ2
15.00Single8X7ATreprostinil8X7A-I2-Treprostinil-Gs/β1/γ2
15.00Single8YN3Histamine8YN3-H2-Histamine-Gs/β1/γ2
15.00Single8ZPMAMD0708ZPM-CXCR4-AMD070-Cholesterol
15.00Single8ZPNAMD31008ZPN-CXCR4-AMD3100-Cholesterol
15.00Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
15.00Single9CBLEpinephrine9CBL-α2a-Epinephrine-Gi1/β1/γ2
15.00Single9EPP11,20-Ethanoretinal9EPP-Rhodopsin-11,20-Ethanoretinal-chim(Gi1-CtGq)/β1/γ2
15.00Single9JKQMETH9JKQ-TA1-METH-Gs/β1/γ2
15.00Single9MQIIsoquinuclidine9MQI-μ-Isoquinuclidine
15.00Consensusat1_offOrthosteric Ligand4YAY-AT1-ZD-7155 4ZUD-AT1-Olmesartan
15.00Consensuscb1_offOrthosteric Ligand5U09-CB1-Taranabant 5TGZ-CB1-AM6538
15.00Consensusghrelin_offOrthosteric Ligand6KO5-Ghrelin-PubChem 57400002 7F83-Ghrelin-PF-05190457
15.00Consensusgrh_offOrthosteric Ligandgnrh1_off
15.00Consensushca_onOrthosteric Ligandhca2_on
15.00Consensusnop_offOrthosteric Ligand4EA3-NOP-PubChem 10296561 5DHG-NOP-C-35 5DHH-NOP-SB-612111
15.00Consensusopsins_offOrthosteric Ligandrhodopsin_off
15.00Consensusot_offOrthosteric Ligand6TPK-OT-Retosiban
15.00Consensussensory_offOrthosteric Ligandopsins_off
15.00Consensusvasop-oxy_offOrthosteric Ligandot_off
14.81Single7E14Orforglipron7E14-GLP-1-Orforglipron-PubChem 156022738-Gs/β1/γ2
14.81Single7EZKCholecystokinin-87EZK-CCKA-Cholecystokinin-8-chim(NtGi1-Gs)/β1/γ2
14.81Single7SK5CXCL127SK5-ACKR3-CXCL12
14.81Single7TRYUrocortin7TRY-CRF2-Urocortin-chim(NtGi1-G11)/β1/γ2
14.81Single8IOCGamma-MSH8IOC-MC3-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
14.81Single8K6OPro-neuropeptide-Y8K6O-Y1-Pro-neuropeptide-Y-Gi2/β1/γ1
14.81Single8SG1Chemerin-98SG1-CML1-Chemerin-9-Gi1/β1/γ2
14.81Consensuscckb_onOrthosteric Ligand8IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/β1/γ2 7XOW-CCKB-Gastrin-chim(NtGi1-Gq)/β1/γ2 7F8V-CCKB-Gastrin-17-Gi2/β1/γ2
14.81Consensusgi_cckOrthosteric Ligand7EZH-CCKA-Cholecystokinin-8-Gi1/β1/γ2 7F8V-CCKB-Gastrin-17-Gi2/β1/γ2
14.71Single8F2APramlintide Analogue San3858F2A-CT (AMY3)-Pramlintide Analogue San385-Gs/β1/γ2; RAMP3
14.71Single8FLSAbaloparatide8FLS-PTH1-Abaloparatide-Gs/β1/γ2
14.29Single1HZX11-cis-Retinal1HZX-Rhodopsin-11-cis-Retinal
14.29Single3NYAS-Alprenolol3NYA-β2-S-Alprenolol
14.29Single4YAYZD-71554YAY-AT1-ZD-7155
14.29Single5NDDAZ8838; Na5NDD-PAR2-AZ8838; Na
14.29Single6K42Dexmedetomidine6K42-α2b-Dexmedetomidine-Gi1/β1/γ2
14.29Single6VN7PACAP6VN7-VPAC1-PACAP-Gs/β1/γ2
14.29Single6Z10PubChem 1545855546Z10-Succinate-PubChem 154585554
14.29Single7E32Serotonin7E32-5-HT1D-Serotonin-Gi1/β1/γ2
14.29Single7M3JNPS-2143; PO47M3J-CaS-NPS-2143; PO4
14.29Single7SK8CXCL127SK8-ACKR3-CXCL12-CCX662
14.29Single7T6TfMLFII7T6T-FPR1-ALX-fMLFII-Gi1/β1/γ2
14.29Single7UM55-CT7UM5-5-HT5A-5-CT-chim(NtGi1-Go)/β1/γ2
14.29Single7VVMPTH7VVM-PTH1-PTH-Gs/β1/γ2
14.29Single7W55Neuromedin-U-257W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
14.29Single7WQ3Galanin7WQ3-GAL1-Galanin-Gi1/β1/γ2
14.29Single7YACPaltusotine7YAC-SST2-Paltusotine-Gi1/β1/γ2
14.29Single8JJOAlprenolol8JJO-β2-Alprenolol
14.29Single8JLJT1AM8JLJ-TA1-T1AM-chim(NtGi1-Gs)/β1/γ2
14.29Single8K5DGSK2560738K5D-HCA2-GSK256073
14.29Single8PJKST1718PJK-5-HT1A-ST171-t7m-Gi1/β1/γ1
14.29Single8T1WCVN4248T1W-GPR6-CVN424
14.29Single8TH3AT118-H Nanobody8TH3-AT1-AT118-H Nanobody
14.29Single8UWLLisuride8UWL-5-HT2A-Lisuride-chim(NtGi2-Gs-CtGq)/β1/γ2
14.29Single8W8ARO52563908W8A-TA1-RO5256390-chim(NtGi1L-Gs)/β1/γ2
14.29Single8WC7ZH86678WC7-TA1-ZH8667-chim(NtGi1-Gs)/β1/γ2
14.29Single8X63Mepyramine8X63-H1-Mepyramine
14.29Single8X64Desloratadine8X64-H1-Desloratadine
14.29Single8XJLPGF2-alpha8XJL-FP-alpha-PGF2-α-chim(NtGi2-Gs-CtGq)/β1/γ2
14.29Single8XZGApelin-138XZG-Apelin-Apelin-13-Gi1/β1/γ2
14.29Single8Y63C20:0 Ceramide8Y63-FPR2-ALX-C20:0 Ceramide-Gi1/β1/γ2
14.29Single8ZQEGPR15L(C11)8ZQE-GPR15-GPR15L(C11)-Gi1/β1/γ1
14.29Single9JR2PTH9JR2-PTH1-PTH-chim(NtGi1L-Gs-CtGq)/β1/γ2
14.29Consensus5ht1d_onOrthosteric Ligand7E32-5-HT1D-Serotonin-Gi1/β1/γ2
14.29Consensus5ht1d_on_gpOrthosteric Ligand7E32-5-HT1D-Serotonin-Gi1/β1/γ2
14.29Consensusalicarboxylic_offOrthosteric Ligandsuccinate_off
14.29Consensusalpha2_onOrthosteric Ligandalpha2b_on
14.29Consensusalpha2_on_gpOrthosteric Ligandalpha2b_on_gp
14.29Consensusalpha2b_onOrthosteric Ligand6K42-α2b-Dexmedetomidine-Gi1/β1/γ2
14.29Consensusalpha2b_on_gpOrthosteric Ligand6K42-α2b-Dexmedetomidine-Gi1/β1/γ2
14.29Consensuscck_offOrthosteric Ligandccka_off
14.29Consensusccka_offOrthosteric Ligand7F8Y-CCKA-Devazepide 7F8U-CCKA-Lintitript
14.29Consensusgal1_onOrthosteric Ligand7WQ3-GAL1-Galanin-Gi1/β1/γ2
14.29Consensusgal1_on_gpOrthosteric Ligand7WQ3-GAL1-Galanin-Gi1/β1/γ2
14.29Consensusgi_galaninOrthosteric Ligand7WQ3-GAL1-Galanin-Gi1/β1/γ2
14.29Consensushistamine_offOrthosteric Ligandh1_off
14.29Consensusnmur2_onOrthosteric Ligand7W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
14.29Consensusnmur2_on_gpOrthosteric Ligand7W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
14.29Consensussuccinate_offOrthosteric Ligand6RNK-Succinate-NF-56-EJ40 6Z10-Succinate-PubChem 154585554
13.89Single7TYOCalcitonin7TYO-CT-Calcitonin-Gs/β1/γ2
13.89Single8JITMEDI03828JIT-Glucagon-MEDI0382-Gs/β1/γ2
13.79Single7AD3Alpha-factor mating pheromone7AD3-STE2-α-factor mating pheromone-Gi1/STE4/γ2
13.79Single7FINPeptide-20; GGL7FIN-GIP-Peptide-20; GGL-Gs/β1/γ2
13.79Single7W57Neuromedin-S7W57-NMUR2-Neuromedin-S-chim(NtGi1-Gs-CtGq)/β1/γ2
13.79Single7WUIIP157WUI-ADGRG2-IP15-chim(NtGi1-Gs)/β1/γ2
13.79Single8YW5Retatrutide8YW5-Glucagon-Retatrutide-Gs/β1/γ2
13.79Consensusneuromedin-u_onOrthosteric Ligandnmur1_on nmur2_on
13.64Single5T1APubChem 68764898; PubChem 120931705T1A-CCR2-PubChem 68764898; PubChem 12093170
13.64Single5WIUNemonapride5WIU-D4-Nemonapride
13.64Single5WIVNemonapride5WIV-D4-Nemonapride-Na
13.64Single5YHLPubChem 1351213525YHL-EP4-PubChem 135121352
13.64Single5YWYONO-AE3-2085YWY-EP4-ONO-AE3-208
13.64Single5ZBQUR-MK-2995ZBQ-Y1-UR-MK-299
13.64Single5ZK33-quinuclidinyl-benzilate5ZK3-M2-3-quinuclidinyl-benzilate
13.64Single6ME72-Phenylmelatonin6ME7-MT2-2-Phenylmelatonin
13.64Single6PS6Timolol6PS6-β2-Timolol
13.64Single6Z4QSR142948A6Z4Q-NTS1-SR142948A
13.64Single7BB7AVP7BB7-V2-AVP-Gs/β1/γ2
13.64Single7E9GJNJ-404118137E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/β1/γ2
13.64Single7EUOfMLF7EUO-FPR1-ALX-fMLF-Gi1/β1/γ2
13.64Single7M3JNPS-2143; PO47M3J-CaS-NPS-2143; PO4
13.64Single8EFBOliceridine8EFB-μ-Oliceridine-Gi1/β1/γ2
13.64Single8GD9Rivenprost8GD9-EP4-Rivenprost-Gs/β1/γ2
13.64Single8HNLPS3724248HNL-CXCR3-PS372424-Gi1/β1/γ2
13.64Single8J18(3R)-3-Hydroxydodecanoic acid8J18-GPR84-(3R)-3-Hydroxydodecanoic acid-Gi1/β1/γ2
13.64Single8TH4Losartan8TH4-AT1-Losartan-AT118-L Nanobody
13.64Single8VVEnorBNI8VVE-κ-norBNI-Gi1/β1/γ2
13.64Single8XQPCholesterol8XQP-TAS2R14-Cholesterol-Aristolochic acid A-Gt3/β1/γ1
13.64Single8XYKVUF106618XYK-CXCR3-VUF10661-Go1/β1/γ2
13.64Single9DQHEP-28259DQH-MRGPRD-EP-2825-chim(NtGi1-Gs-CtGq)/β1/γ2
13.64Single9DQJEP-39459DQJ-MRGPRD-EP-3945-chim(NtGi1-Gs-CtGq)/β1/γ2
13.64Single9EAHNanobody AT2099EAH-AT1-Olmesartan-Nanobody AT209
13.64Single9F34FOB02-04A9F34-D3-FOB02-04A-Go1/β1/γ2
13.64Consensus5ht1_onOrthosteric Ligand5ht1a_on 5ht1d_on 5ht1e_on 5ht1f_on
13.64Consensus5ht1_on_gpOrthosteric Ligand5ht1a_on_gp 5ht1d_on_gp 5ht1e_on_gp 5ht1f_on_gp
13.64Consensus5ht1e_on_gpOrthosteric Ligand7E33-5-HT1E-BRL-54443-Gi1/β1/γ2 8UGY-5-HT1E-Mianserin-Gi1/β1/γ1 8UH3-5-HT1E-Setiptiline-Gi1/β1/γ1
13.64Consensus5ht2_offOrthosteric Ligand5ht2a_off 5ht2b_off 5ht2c_off
13.64Consensusblt1_offOrthosteric Ligand5X33-BLT1-BIIL260 7K15-BLT1-MKD046-Na
13.64Consensusblt_offOrthosteric Ligandblt1_off
13.64Consensusep4_offOrthosteric Ligand5YWY-EP4-ONO-AE3-208 5YHL-EP4-PubChem 135121352
13.64Consensusep_offOrthosteric Ligandep4_off
13.33Single5MZPCaffeine5MZP-A2A-Caffeine-Na
13.33Single7TYHCalcitonin-17TYH-CT (AMY2)-Calcitonin-1-Gs/β1/γ2; RAMP2
13.33Single7TYWCalcitonin-17TYW-CT (AMY1)-Calcitonin-1-Gs/β1/γ2; RAMP1
13.33Single7VL9CCL15(26-92)7VL9-CCR1-CCL15(26-92)-Gi1/β1/γ2
13.33Single7Y35Abaloparatide7Y35-PTH1-Abaloparatide-Gs/β1/γ2
13.33Single8WCCCyclohexylammonium Ion8WCC-TA1-Cyclohexylammonium Ion
13.33Single8WWMMCH8WWM-MCH1-MCH-Gi1/β1/γ2
13.04Single3UON3-quinuclidinyl-benzilate3UON-M2-3-quinuclidinyl-benzilate
13.04Single4U15Tiotropium4U15-M3-Tiotropium
13.04Single5V54Methiothepin5V54-5-HT1B-Methiothepin
13.04Single5ZBHBMS-1938855ZBH-Y1-BMS-193885
13.04Single6O3CCholesterol6O3C-SMO-SAG21k-Cholesterol
13.04Single6OL9Tiotropium6OL9-M5-Tiotropium
13.04Single7EW4CYM55417EW4-S1P3-CYM5541-Gi1/β1/γ2
13.04Single7R0CAVP7R0C-V2-AVP-Arrestin2
13.04Single7SK7CXCL127SK7-ACKR3-CXCL12-CCX662
13.04Single7T9NPubChem 6440787T9N-TSH-M22 Fab-PubChem 644078-Gs/β1/γ2
13.04Single7XBDGalanin7XBD-GAL2-Galanin-chim(NtGi2L-Gs-CtGq)/β1/γ2
13.04Single8I2GCompound 7163408I2G-FSH-Glycoprotein hormones α chain-Compound 716340-Gs/β1/γ2
13.04Single8XQTCholesterol8XQT-TAS2R14-Cholesterol-Cholesterol-Gi1/β1/γ1
13.04Single8XZICMF-0198XZI-Apelin-CMF-019-Gi1/β1/γ2
13.04Single8ZR5Firuglipel8ZR5-GPR119-Firuglipel-Gs/β1/γ2
13.04Consensus5ht1_offOrthosteric Ligand5ht1b_off
13.04Consensus5ht1b_offOrthosteric Ligand5V54-5-HT1B-Methiothepin
13.04Consensus5ht_offOrthosteric Ligand5ht2_off 5ht1_off
13.04Consensush4_on_gpOrthosteric Ligand8HN8-H4-Histamine-Gi1/β1/γ2 8HOC-H4-Imetit-Gi1/β1/γ2 8JXV-H4-Clozapine-Gi1/β1/γ2 8JXW-H4-VUF6884-Gi1/β1/γ2 8JXX-H4-Clobenpropit-Gi1/β1/γ2
13.04Consensusm3_offOrthosteric Ligand4U15-M3-Tiotropium 4U16-M3-N-Methyl-Scopolamine 5ZHP-M3-PubChem 134828589
13.04Consensusm5_offOrthosteric Ligand6OL9-M5-Tiotropium
13.04Consensusmuscarinic_offOrthosteric Ligandm2_off m3_off m4_off m5_off m1_off
13.04Consensusnpy1_offOrthosteric Ligand5ZBH-Y1-BMS-193885 5ZBQ-Y1-UR-MK-299
12.90Single6FJ3PTH6FJ3-PTH1-PTH
12.90Single6P9YPACAP6P9Y-PAC1-PACAP-Gs/β1/γ2
12.90Single7CZ5Somatoliberin7CZ5-GHRH-Somatoliberin-Gs/β1/γ2
12.50Single5CXVTiotropium5CXV-M1-Tiotropium
12.50Single5NX2GLP-1 (Truncated)5NX2-GLP-1-GLP-1 (Truncated)
12.50Single5X33BIIL2605X33-BLT1-BIIL260
12.50Single6AK3Dinoprostone IPGE26AK3-EP3-Dinoprostone IPGE2
12.50Single6DRYMethylergonovine6DRY-5-HT2B-Methylergonovine
12.50Single7DFPSpiperone7DFP-D2-Spiperone
12.50Single7K15MKD0467K15-BLT1-MKD046-Na
12.50Single7TYFAmylin7TYF-CT (AMY1)-Amylin-Gs/β1/γ2; RAMP1
12.50Single7TYNCalcitonin-17TYN-CT-Calcitonin-1-Gs/β1/γ2
12.50Single7V68PubChem 576644067V68-M4-Iperoxo-PubChem 57664406-Gi1/β1/γ2
12.50Single7W0LPubChem 1227019087W0L-Apelin-PubChem 122701908-Gi1/β1/γ2
12.50Single7WC4Serotonin7WC4-5-HT2A-Serotonin
12.50Single7WCNAR2314537WCN-GPR119-AR231453-Gs/β1/γ2
12.50Single7WQ4Galanin7WQ4-GAL2-Galanin-chim(NtGi1-Gs-CtGq)/β1/γ2
12.50Single7XKDBeta-Hydroxyandrosterone7XKD-ADGRG2-β-Hydroxyandrosterone-Gs/β1/γ2
12.50Single7XZ5Lysophosphatidylcholine7XZ5-GPR119-Lysophosphatidylcholine-Gs/β1/γ2
12.50Single8E9W2-Deoxycytidine8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/β1/γ2
12.50Single8G056-OAU8G05-GPR84-6-OAU-Gi1/β1/γ2
12.50Single8GCPPGE28GCP-EP4-PGE2-Gi1/β1/γ2
12.50Single8HQMNPGLY8HQM-GPR132-NPGLY-Gi1/β1/γ2
12.50Single8HS2Fab0468HS2-GPR20-Fab046
12.50Single8VHFMBX-29828VHF-GPR119-MBX-2982-Gs/β1/γ2
12.50Consensus5ht1a_onOrthosteric Ligand8FYT-5-HT1A-LSD-Gi1/β1/γ1 7E2Y-5-HT1A-Serotonin-Gi1/β1/γ2 7E2Z-5-HT1A-Aripiprazole-Gi1/β1/γ2 8FYX-5-HT1A-Buspirone-Gi1/β1/γ1 8JSP-5-HT1A-Ulotaront-Gi1/β1/γ2 8JT6-5-HT1A-(R)-IHCH-7179-Gi1/β1/γ2 8FY8-5-HT1A-5-MeO-DMT-Gi1/β1/γ1 8FYE-5-HT1A-4-F,5-MeO-PyrT-Gi1/β1/γ1 8FYL-5-HT1A-Vilazodone-Gi1/β1/γ1
12.50Consensus5ht1a_on_gpOrthosteric Ligand8FYT-5-HT1A-LSD-Gi1/β1/γ1 8FYX-5-HT1A-Buspirone-Gi1/β1/γ1 8JSP-5-HT1A-Ulotaront-Gi1/β1/γ2 8JT6-5-HT1A-(R)-IHCH-7179-Gi1/β1/γ2 7E2Y-5-HT1A-Serotonin-Gi1/β1/γ2 7E2Z-5-HT1A-Aripiprazole-Gi1/β1/γ2 8FY8-5-HT1A-5-MeO-DMT-Gi1/β1/γ1 8FYE-5-HT1A-4-F,5-MeO-PyrT-Gi1/β1/γ1 8FYL-5-HT1A-Vilazodone-Gi1/β1/γ1
12.50Consensusgalanin_onOrthosteric Ligandgal2_on gal1_on
12.50Consensusgalanin_on_gpOrthosteric Ligandgal2_on_gp gal1_on_gp
12.50Consensusgi_muscarinicOrthosteric Ligand8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/β1/γ2 7T8X-M2-Acetylcholine-chim(NtGi1-Go)/β1/γ2 7TRS-M4-Acetylcholine-Gi1/β1/γ2 7TRK-M4-Iperoxo-Gi1/β1/γ2 7V6A-M4-PubChem 9864275-Gi1/β1/γ2
12.50Consensusm1_offOrthosteric Ligand5CXV-M1-Tiotropium
12.50Consensusm4_onOrthosteric Ligand7TRS-M4-Acetylcholine-Gi1/β1/γ2 7V6A-M4-PubChem 9864275-Gi1/β1/γ2 8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/β1/γ2 7TRK-M4-Iperoxo-Gi1/β1/γ2
12.50Consensusm4_on_gpOrthosteric Ligand7TRS-M4-Acetylcholine-Gi1/β1/γ2 7V6A-M4-PubChem 9864275-Gi1/β1/γ2 8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/β1/γ2 7TRK-M4-Iperoxo-Gi1/β1/γ2
12.12Single6LMKGlucagon6LMK-Glucagon-Glucagon-Gs/β1/γ2
12.12Single8FLTM-PTH(1-14)8FLT-PTH1-M-PTH(1-14)-Gs/β1/γ2
12.00Single7D7MDinoprostone7D7M-EP4-Dinoprostone-Gs/β1/γ1
12.00Single7XZ6APD6687XZ6-GPR119-APD668-Gs/β1/γ2
12.00Single8IULLatanoprost8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/β1/γ2
12.00Single8K2XCXCL108K2X-CXCR3-CXCL10-Gi1/β1/γ2
12.00Consensusd2_offOrthosteric Ligand6CM4-D2-Risperidone 6LUQ-D2-Haloperidol 7DFP-D2-Spiperone
12.00Consensusfp-alpha_onOrthosteric Ligand8IUK-FP-alpha-PGF2-α-chim(NtGi1-Gs-CtGq)/β1/γ2 8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/β1/γ2 8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/β1/γ2
12.00Consensusfp-alpha_on_gpOrthosteric Ligand8IUK-FP-alpha-PGF2-α-chim(NtGi1-Gs-CtGq)/β1/γ2 8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/β1/γ2 8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/β1/γ2
11.76Single6OY9All-trans-Retinal6OY9-Rhodopsin-All-trans-Retinal-Gt/β1/γ1
11.76Single6TQ9SB-4081246TQ9-OX1-SB-408124
11.76Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
11.76Single7VDMSubstance-P7VDM-MRGPRX2-Substance-P-Gi1/β1/γ2
11.76Single8DPHLorcaserin8DPH-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/β1/γ2
11.76Single8IWM2-Phenylethylamine8IWM-TA9-2-Phenylethylamine
11.76Single8U4QREGN7663-Fab8U4Q-CXCR4-REGN7663-Fab-Cholesterol-Gi1/β1/γ2
11.76Single9CHUNoradrenaline9CHU-β2-Noradrenaline
11.76Consensusgs_histamineOrthosteric Ligand8POK-H2-Histamine-Gs/β1/γ2
11.76Consensush2_onOrthosteric Ligand8POK-H2-Histamine-Gs/β1/γ2
11.54Single7YAEOctreotide7YAE-SST2-Octreotide-Gi1/β1/γ2
11.54Single8GDAL9026888GDA-EP4-L902688-Gs/β1/γ2
11.54Single8IQ4Carboprost8IQ4-FP-alpha-Carboprost-chim(NtGi1-Gs-CtGq)/β1/γ2
11.54Single8IUMTafluprost acid8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/β1/γ2
11.54Consensussst2_onOrthosteric Ligand7WIC-SST2-Somatostatin-14-Gi1/β1/γ2 7WIG-SST2-L-054,264-Gi1/β1/γ2 7YAE-SST2-Octreotide-Gi1/β1/γ2 7YAC-SST2-Paltusotine-Gi1/β1/γ2
11.54Consensussst2_on_gpOrthosteric Ligand7WIC-SST2-Somatostatin-14-Gi1/β1/γ2 7WIG-SST2-L-054,264-Gi1/β1/γ2 7YAE-SST2-Octreotide-Gi1/β1/γ2 7YAC-SST2-Paltusotine-Gi1/β1/γ2
11.43Single7TZFAmylin7TZF-CT (AMY3)-Amylin-Gs/β1/γ2; RAMP3
11.11Single3C9M11-cis-Retinal3C9M-Rhodopsin-11-cis-Retinal
11.11Single6FUFAll-trans-Retinal6FUF-Rhodopsin-All-trans-Retinal-Go
11.11Single6OIKLY21196206OIK-M2-Iperoxo-LY2119620-chim(NtGi1-Go)/β1/γ2
11.11Single7F23Dopamine7F23-D1-Dopamine-GDP-Gs/β1/γ2
11.11Single7MT8All-trans-Retinal7MT8-Rhodopsin-All-trans-Retinal-GRK1
11.11Single7MT9All-trans-Retinal7MT9-Rhodopsin-All-trans-Retinal-GRK1
11.11Single7MTAAll-trans-Retinal7MTA-Rhodopsin-All-trans-Retinal-GRK1
11.11Single7V6A-7V6A-M4-PubChem 9864275-Gi1/β1/γ2
11.11Single7W56Neuromedin-S7W56-NMUR1-Neuromedin-S-chim(NtGi1-Gs-CtGq)/β1/γ2
11.11Single7XMRSomatostatin-147XMR-SST2-Somatostatin-14-Gi1/β1/γ2
11.11Single8ITFDMCHA8ITF-TA9-DMCHA-chim(NtGi1-Gs)/β1/γ2
11.11Single8IW72-Phenylethylamine8IW7-TA9-2-Phenylethylamine-chim(NtGi1-Gs)/β1/γ2
11.11Single8JXTHistamine8JXT-H4-Histamine-PO4-Gi1/β1/γ2
11.11Single8POKHistamine8POK-H2-Histamine-Gs/β1/γ2
11.11Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
11.11Single8WC62-Phenylethylamine8WC6-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/β1/γ2
11.11Single8WC9ZH86518WC9-TA1-ZH8651-chim(NtGi1-Gs-CtGq)/β1/γ2
11.11Single8YN9Histamine8YN9-H4-Histamine-Gi1/β1/γ2
11.11Single8YUUHistamine8YUU-H3-Histamine-Gi1/β1/γ1
11.11Single9C1PCa; Tryptophan; '6218; PO49C1P-CaS-Ca-Ca; Tryptophan; '6218; PO4
11.11Consensush2_on_gpOrthosteric Ligand8POK-H2-Histamine-Gs/β1/γ2
11.11Consensush3_onOrthosteric Ligand8YUU-H3-Histamine-Gi1/β1/γ1
11.11Consensush3_on_gpOrthosteric Ligand8YUU-H3-Histamine-Gi1/β1/γ1
10.81Single7TYYCalcitonin-17TYY-CT (AMY2)-Calcitonin-1-Gs/β1/γ2; RAMP2
10.71Single6WHCGlu16 analog of GCG6WHC-Glucagon-Glu16 analog of GCG-Gs/β1/γ2
10.53Single1L9H11-cis-Retinal1L9H-Rhodopsin-11-cis-Retinal
10.53Single5TE520-Methanoretinal5TE5-Rhodopsin-20-Methanoretinal
10.53Single7E2YSerotonin7E2Y-5-HT1A-Serotonin-Gi1/β1/γ2
10.53Single7UL2SR486927UL2-NTS1-SR48692-Na
10.53Single7YFCHistamine7YFC-H4-Histamine-chim(NtGi1-Gs-CtGq)/β1/γ2
10.53Single7YFDImetit7YFD-H4-Imetit-chim(NtGi1-Gs-CtGq)/β1/γ2
10.53Single7YS6Serotonin7YS6-5-HT6-Serotonin-chim(NtGi1-Gs)/β1/γ2
10.53Single8DPFLorcaserin8DPF-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/β1/γ2
10.53Single8FX5Xanomeline8FX5-M4-Xanomeline-Xanomeline-Gi1/β1/γ2
10.53Single8H2GNiacin8H2G-HCA2-Niacin-Gi1/β1/γ2
10.53Single8HN8Histamine8HN8-H4-Histamine-Gi1/β1/γ2
10.53Single8HSCFab0468HSC-GPR20-Fab046-Gi1/β1/γ2
10.53Single8JILNiacin8JIL-HCA2-Niacin-Gi1/β1/γ2
10.53Single8K5BNiacin8K5B-HCA2-Niacin
10.53Single8W89PEA8W89-TA1-PEA-chim(NtGi1L-Gs)/β1/γ2
10.53Single8X2KOleic monoethanolamide8X2K-GPR3-Oleic monoethanolamide-chim(NtGi1-Gs)/β1/γ2
10.53Single8Y0NVUF114188Y0N-CXCR3-VUF11418-Go1/β1/γ2
10.53Single8YN5Histamine8YN5-H3-Histamine-Gi1/β1/γ2
10.53Single8YN6Imetit8YN6-H3-Imetit-Gi1/β1/γ2
10.53Single8YN7Immethridine8YN7-H3-Immethridine-Go1/β1/γ2
10.53Single8YRGFospropofol8YRG-MRGPRX4-Fospropofol-chim(NtGi1-Gs-CtGq)/β1/γ2
10.53Single8YUVImmepip8YUV-H3-Immepip-Gi1/β1/γ2
10.53Single9EPQ11,20-Ethanoretinal9EPQ-Rhodopsin-11,20-Ethanoretinal-chim(Gi1-CtGq)/β1/γ2
10.53Single9EPRRetinal9EPR-Rhodopsin-Retinal-Gi1/β1/γ2
10.53Single9IQTNiacin9IQT-HCA2-Niacin-Gi1/β1/γ2
10.53Consensusgq_nucleotideOrthosteric Ligandgq_p2y
10.53Consensusgq_p2yOrthosteric Ligand7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/β1/γ2
10.53Consensush4_onOrthosteric Ligand8HN8-H4-Histamine-Gi1/β1/γ2 8HOC-H4-Imetit-Gi1/β1/γ2 8JXV-H4-Clozapine-Gi1/β1/γ2 8JXW-H4-VUF6884-Gi1/β1/γ2 8JXX-H4-Clobenpropit-Gi1/β1/γ2
10.53Consensusneurotensin_offOrthosteric Ligandnts1_off
10.53Consensusnts1_offOrthosteric Ligand7UL2-NTS1-SR48692-Na
10.00Single2PED9-cis-Retinal2PED-Rhodopsin-9-cis-Retinal
10.00Single6KUYPubChem 1457046436KUY-α2a-PubChem 145704643
10.00Single6OYAAll-trans-Retinal6OYA-Rhodopsin-All-trans-Retinal-Gt/β1/γ1
10.00Single7LJDDopamine7LJD-D1-Dopamine-Mevidalen-Gs/β1/γ1
10.00Single7T8XAcetylcholine7T8X-M2-Acetylcholine-chim(NtGi1-Go)/β1/γ2
10.00Single7T90Acetylcholine7T90-M2-Acetylcholine-chim(NtGi1-Go)/β1/γ2
10.00Single7T96Acetylcholine7T96-M2-Acetylcholine-LY2119620-Go/β1/γ2
10.00Single7YM8Oxymetazoline7YM8-Alpha1A-Oxymetazoline-chim(Gs-CtGq)
10.00Single8A6CAll-trans-Retinal8A6C-Rhodopsin-All-trans-Retinal
10.00Single8A6DAll-trans-Retinal8A6D-Rhodopsin-All-trans-Retinal
10.00Single8A6EAll-trans-Retinal8A6E-Rhodopsin-All-trans-Retinal
10.00Single8HOCImetit8HOC-H4-Imetit-Gi1/β1/γ2
10.00Single8IW4Spermidine8IW4-TA9-Spermidine-chim(NtGi1-Gs)/β1/γ2
10.00Single8IWESpermidine8IWE-TA9-Spermidine
10.00Single8U4PAMD31008U4P-CXCR4-AMD3100-Cholesterol-Gi1/β1/γ2
10.00Single8U4SREGN7663-Fab8U4S-CXCR4-REGN7663-Fab
10.00Single8U4TREGN7663-Fab8U4T-CXCR4-REGN7663-Fab
10.00Single8U8FPalmitic Acid8U8F-GPR3-Palmitic Acid-Gs/β1/γ2
10.00Single8WC3SEP-3638568WC3-TA1-SEP-363856-chim(NtGi1-Gs)/β1/γ2
10.00Single8XXVIndomethacin8XXV-DP2-Indomethacin-A1D5Q-Gi1/β1/γ2
10.00Single8Y0HVUF114188Y0H-CXCR3-VUF11418
10.00Single8YNAImmepip8YNA-H4-Immepip-Gi1/β1/γ
10.00Single9BQJRO769BQJ-μ-RO76-Gi1/β1/γ2
10.00Consensusangiotensin_offOrthosteric Ligandat1_off
10.00Consensusgq_histamineOrthosteric Ligand7DFL-H1-Histamine-chim(NtGi1L-Gq)/β1/γ2
10.00Consensush1_on_gpOrthosteric Ligand7DFL-H1-Histamine-chim(NtGi1L-Gq)/β1/γ2
10.00Consensushistamine_onOrthosteric Ligandh1_on h2_on h3_on h4_on
10.00Consensushistamine_on_gpOrthosteric Ligandh1_on_gp h2_on_gp h3_on_gp h4_on_gp
10.00Consensusm2_onOrthosteric Ligand7T8X-M2-Acetylcholine-chim(NtGi1-Go)/β1/γ2
10.00Consensusm2_on_gpOrthosteric Ligand7T8X-M2-Acetylcholine-chim(NtGi1-Go)/β1/γ2
10.00Consensusrhodopsin_offOrthosteric Ligand1U19-Rhodopsin-11-cis-Retinal 2PED-Rhodopsin-9-cis-Retinal 5TE5-Rhodopsin-20-Methanoretinal
10.00Consensusrhodopsin_on_gpOrthosteric Ligand6OYA-Rhodopsin-All-trans-Retinal-Gt/β1/γ1
10.00Consensussensory_offonOrthosteric Ligandsensory_off sensory_on
10.00Consensussensory_offon_gpOrthosteric Ligandsensory_on_gp sensory_on
9.76Single8F0JPramlintide Analogue San458F0J-CT-Pramlintide Analogue San45-Gs/β1/γ2
9.52Single3RZECidoxepin3RZE-H1-Cidoxepin
9.52Single4MQTIperoxo4MQT-M2-Iperoxo-LY2119620
9.52Single6A94Zotepine6A94-5-HT2A-Zotepine
9.52Single6WH4Methiothepin6WH4-5-HT2A-Methiothepin
9.52Single6WJCAtropine6WJC-M1-Atropine-Muscarinic toxin 7
9.52Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
9.52Single7T94Acetylcholine7T94-M2-Acetylcholine-PubChem 57664406-chim(NtGi1-Go)/β1/γ2
9.52Single7TRSAcetylcholine7TRS-M4-Acetylcholine-Gi1/β1/γ2
9.52Single8DPGPsilocin8DPG-5-HT2C-Psilocin-chim(NtGi2L-Gs-CtGq)/β1/γ2
9.52Single8F2BPramlintide Analogue San458F2B-CT (AMY3)-Pramlintide Analogue San45-Gs/β1/γ2; RAMP3
9.52Single8JEI3-nitro-4-(propylamino)benzoic acid8JEI-HCAR3-3-nitro-4-(propylamino)benzoic acid-Gi1/β1/γ2
9.52Single8JLNT1AM8JLN-TA1-T1AM-Gs/β1/γ2
9.52Single8JSPUlotaront8JSP-5-HT1A-Ulotaront-Gi1/β1/γ2
9.52Single8PM2DMCH8PM2-TA7-DMCH-Gs/β1/γ2
9.52Single8UHBRO52563908UHB-TA1-RO5256390-Gs/β1/γ2
9.52Single8Y01Retinal8Y01-Opsin1MW-Retinal-Gi1/β1/γ2
9.52Single8Y53MK50468Y53-BB3-MK5046-chim(NtGi1-Gs-CtGq)/β1/γ2
9.52Single8YN8Proxyfan8YN8-H3-Proxyfan-Go1/β1/γ2
9.52Single8ZMGPimavanserin8ZMG-5-HT2A-Pimavanserin
9.52Consensus5ht2a_offOrthosteric Ligand6A94-5-HT2A-Zotepine 6A93-5-HT2A-Risperidone 7VOD-5-HT2A-Cariprazine 7WC8-5-HT2A-Lumateperone 8JT8-5-HT2A-(R)-IHCH-7179
9.38Single6NBILong-Acting PTH Analog6NBI-PTH1-Long-Acting PTH Analog-Gs/β1/γ2
9.09Single4DAJTiotropium4DAJ-M3-Tiotropium
9.09Single4MQSIperoxo4MQS-M2-Iperoxo
9.09Single4U14Tiotropium4U14-M3-Tiotropium
9.09Single4U16N-Methyl-Scopolamine4U16-M3-N-Methyl-Scopolamine
9.09Single5DSGTiotropium5DSG-M4-Tiotropium
9.09Single5YC8N-Methyl-Scopolamine5YC8-M2-N-Methyl-Scopolamine
9.09Single5ZK8N-Methyl-Scopolamine5ZK8-M2-N-Methyl-Scopolamine
9.09Single5ZKCN-Methyl-Scopolamine5ZKC-M2-N-Methyl-Scopolamine
9.09Single6DRZMethysergide6DRZ-5-HT2B-Methysergide
9.09Single6IIVDaltroban6IIV-TP-Daltroban
9.09Single6ORVTT-OAD26ORV-GLP-1-TT-OAD2-Gs/β1/γ2
9.09Single6WHADB139486WHA-5-HT2A-DB13948-chim(NtGi2L-Gs-CtGq)/β1/γ2
9.09Single7F83PF-051904577F83-Ghrelin-PF-05190457
9.09Single7TRPIperoxo7TRP-M4-Iperoxo-LY2033298-Gi1/β1/γ2
9.09Single7VH0Ramelteon7VH0-MT2-Ramelteon-Gi1/β1/γ1
9.09Single7WC8Lumateperone7WC8-5-HT2A-Lumateperone
9.09Single8FY85-MeO-DMT8FY8-5-HT1A-5-MeO-DMT-Gi1/β1/γ1
9.09Single8GCML9026888GCM-EP4-L902688-Gi1/β1/γ2
9.09Single8JT8(R)-IHCH-71798JT8-5-HT2A-(R)-IHCH-7179
9.09Single8X9TAP5038X9T-ADGRD1-AP503-chim(NtGi1-Gs)/β1/γ2
9.09Single9IVGGLP-1 (Truncated)9IVG-GLP-1-GLP-1 (Truncated)-chim(NtGi1-Gs)/β1/γ2
9.09Consensus5ht2b_offOrthosteric Ligand6DRZ-5-HT2B-Methysergide
9.09Consensusgi_histamineOrthosteric Ligand8JXX-H4-Clobenpropit-Gi1/β1/γ2 8JXV-H4-Clozapine-Gi1/β1/γ2 8YUU-H3-Histamine-Gi1/β1/γ1 8HN8-H4-Histamine-Gi1/β1/γ2 8HOC-H4-Imetit-Gi1/β1/γ2 8JXW-H4-VUF6884-Gi1/β1/γ2
9.09Consensusgq_amineOrthosteric Ligandgq_muscarinic gq_histamine
9.09Consensusm4_offOrthosteric Ligand5DSG-M4-Tiotropium
9.09Consensusmuscarinic_onOrthosteric Ligandm2_on m3_on m4_on m1_on
9.09Consensusmuscarinic_on_gpOrthosteric Ligandm2_on_gp m3_on_gp m4_on_gp m1_on_gp
8.70Single4WW3All-trans-Retinal4WW3-Rhodopsin-All-trans-Retinal
8.70Single6LUQHaloperidol6LUQ-D2-Haloperidol
8.70Single6M9TMisoprostol-FA6M9T-EP3-Misoprostol-FA
8.70Single6OIKIperoxo6OIK-M2-Iperoxo-LY2119620-chim(NtGi1-Go)/β1/γ2
8.70Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
8.70Single7TRKIperoxo7TRK-M4-Iperoxo-Gi1/β1/γ2
8.70Single7VOEAripiprazole7VOE-5-HT2A-Aripiprazole
8.70Single8E9ZIperoxo8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/β1/γ2
8.70Single8SZICa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZI-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi3/β1/γ2
8.70Single8X0BVU04244658X0B-mGlu5; mGlu5-Quisqualate-VU0424465
8.70Single8X0DVU04244658X0D-mGlu5; mGlu5-Quisqualate-VU0424465
8.70Single8X0DVU04244658X0D-mGlu5; mGlu5-Quisqualate-VU0424465
8.70Single8ZMFA1L108ZMF-5-HT2C-A1L10
8.70Consensusgq_muscarinicOrthosteric Ligand6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/β1/γ2
8.70Consensusm1_onOrthosteric Ligand6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/β1/γ2
8.70Consensusm2_offOrthosteric Ligand5ZKC-M2-N-Methyl-Scopolamine 5ZK3-M2-3-quinuclidinyl-benzilate 5ZKB-M2-AF-DX 384
8.70Consensusm3_onOrthosteric Ligand8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/β1/γ2 8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/β1/γ2 8E9Y-M3-Clozapine-N-oxide-chim(NtGi2L-Gs-CtGq)/β1/γ2
8.70Consensusm3_on_gpOrthosteric Ligand8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/β1/γ2 8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/β1/γ2 8E9Y-M3-Clozapine-N-oxide-chim(NtGi2L-Gs-CtGq)/β1/γ2
8.33Single6OIJIperoxo6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/β1/γ2
8.33Single7P2L4YI7P2L-mGlu5-4YI
8.33Single7TRQIperoxo7TRQ-M4-Iperoxo-VU0467154-Gi1/β1/γ2
8.33Single8EA0Iperoxo8EA0-M3-Iperoxo
8.33Single8GDBPGE28GDB-EP4-PGE2-Gs/β1/γ2
8.33Single8IUKPGF2-alpha8IUK-FP-alpha-PGF2-α-chim(NtGi1-Gs-CtGq)/β1/γ2
8.33Single8JD5BQI; HZE; PEF8JD5-mGlu2; mGlu4-Glutamate-BQI; HZE; PEF-Gi1/β1/γ2
8.33Single8X0BVU04244658X0B-mGlu5; mGlu5-Quisqualate-VU0424465
8.33Single8X0FVU04244658X0F-mGlu5; mGlu5-Quisqualate-VU0424465
8.33Single8X79MRE-2698X79-I2-MRE-269-Gs/β1/γ2
8.33Single8XJMLatanoprost8XJM-FP-alpha-Latanoprost-chim(NtGi2-Gs-CtGq)/β1/γ2
8.33Single9AUCCalcitonin gene-related peptide-19AUC-CT (AMY1)-Calcitonin gene-related peptide-1-Gs/β1/γ2; RAMP1
8.33Consensusm1_on_gpOrthosteric Ligand6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/β1/γ2
8.00Single6IIURamatroban6IIU-TP-Ramatroban
8.00Single8IQ6Latanoprost8IQ6-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/β1/γ2
8.00Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/β1/γ2
8.00Single8XJNCloprosetnol8XJN-TP-Cloprosetnol-chim(NtGi1-Gs-CtGq)/β1/γ2
7.69Single6D32Cyclopamine6D32-SMO-Cyclopamine-Cyclopamine
7.69Single6D35Cholesterol6D35-SMO-Cholesterol
7.69Single6N51Quisqualate6N51-mGlu5; mGlu5-Quisqualate
7.69Single6N51Quisqualate6N51-mGlu5; mGlu5-Quisqualate
7.69Single6UO8SKF975416UO8-GABAB1, GABAB2-SKF97541-GS39783
7.69Single6UO9SKF975416UO9-GABAB1, GABAB2-SKF97541
7.69Single6W2XPubChem 53110426W2X-GABAB1, GABAB2-PubChem 5311042-PubChem 23727970
7.69Single6W2YPubChem 53110426W2Y-GABAB1; GABAB1-PubChem 5311042-PubChem 23727970
7.69Single6W2YPubChem 53110426W2Y-GABAB1; GABAB1-PubChem 5311042-PubChem 23727970
7.69Single7C7QBaclofen7C7Q-GABAB1, GABAB2-Baclofen-PubChem 7023848
7.69Single7C7SCGP546267C7S-GABAB1, GABAB2-CGP54626
7.69Single7CUMCGP546267CUM-GABAB1, GABAB2-CGP54626-Phospholipid
7.69Single7CX4Evatanepag7CX4-EP2-Evatanepag-Gs/β1/γ2
7.69Single7DD5Ca7DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
7.69Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
7.69Single7DD5Ca7DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
7.69Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
7.69Single7DGEQuisqualate7DGE-mGlu1; mGlu1-Quisqualate
7.69Single7DTTCa7DTT-CaS-Ca-Ca
7.69Single7DTTCa7DTT-CaS-Ca-Ca
7.69Single7DTUTryptophan7DTU-CaS-Tryptophan
7.69Single7DTUTryptophan7DTU-CaS-Tryptophan
7.69Single7DTVCa7DTV-CaS-Ca-Ca; Tryptophan
7.69Single7DTVCa; Tryptophan7DTV-CaS-Ca-Ca; Tryptophan
7.69Single7DTVCa7DTV-CaS-Ca-Ca; Tryptophan
7.69Single7DTVCa; Tryptophan7DTV-CaS-Ca-Ca; Tryptophan
7.69Single7E6TCa7E6T-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
7.69Single7E6TCa; Ca; Cyclomethyltryptophan; PO47E6T-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
7.69Single7E6TCa7E6T-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
7.69Single7E6TCa; Ca; Cyclomethyltryptophan; PO47E6T-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
7.69Single7E9GEglumetad7E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/β1/γ2
7.69Single7E9GEglumetad7E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/β1/γ2
7.69Single7E9HPhosphoserine7E9H-mGlu4; mGlu4-Phosphoserine-Gi3/β1/γ2
7.69Single7E9HPhosphoserine7E9H-mGlu4; mGlu4-Phosphoserine-Gi3/β1/γ2
7.69Single7EB2Baclofen7EB2-GABAB2; GABAB1-Baclofen-rac-BHFF-Gi1/β1/γ2
7.69Single7EPBEglumetad7EPB-mGlu2; mGlu2-Eglumetad
7.69Single7EPBEglumetad7EPB-mGlu2; mGlu2-Eglumetad
7.69Single7FD8Quisqualate7FD8-mGlu5; mGlu5-Quisqualate
7.69Single7FD8Quisqualate7FD8-mGlu5; mGlu5-Quisqualate
7.69Single7FD9LY3414957FD9-mGlu5; mGlu5-LY341495
7.69Single7FD9LY3414957FD9-mGlu5; mGlu5-LY341495
7.69Single7FIHhCG7FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/β1/γ2
7.69Single7FIIhCG7FII-LH-hCG-chim(NtGi1-Gs)/β1/γ2
7.69Single7M3ECa; Ca; Tryptophan; NPS-21437M3E-CaS-Ca; Ca; Tryptophan; NPS-2143
7.69Single7M3ECa; Ca; Tryptophan; NPS-21437M3E-CaS-Ca; Ca; Tryptophan; NPS-2143
7.69Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
7.69Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
7.69Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
7.69Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
7.69Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
7.69Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
7.69Single7MTQLY3414957MTQ-mGlu2; mGlu2-LY341495
7.69Single7MTQLY3414957MTQ-mGlu2; mGlu2-LY341495
7.69Single7MTRGlutamate7MTR-mGlu2; mGlu2-Glutamate-ADX55164
7.69Single7MTRGlutamate7MTR-mGlu2; mGlu2-Glutamate-ADX55164
7.69Single7MTSGlutamate7MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/β1/γ2
7.69Single7MTSGlutamate7MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/β1/γ2
7.69Single7SILCa7SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
7.69Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
7.69Single7SILCa7SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
7.69Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
7.69Single7SIMCa7SIM-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
7.69Single7SIMCa; Ca; Cyclomethyltryptophan; PO47SIM-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
7.69Single7SIMCa7SIM-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
7.69Single7SIMCa; Ca; Cyclomethyltryptophan; PO47SIM-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
7.69Single7T9NM22 Fab7T9N-TSH-M22 Fab-PubChem 644078-Gs/β1/γ2
7.69Single7VVNPTH7VVN-PTH1-PTH-Gs/β1/γ2
7.69Single7WI6LY3414957WI6-mGlu3; mGlu3-LY341495
7.69Single7WI6LY3414957WI6-mGlu3; mGlu3-LY341495
7.69Single7WI8LY3414957WI8-mGlu3; mGlu3-LY341495
7.69Single7WI8LY3414957WI8-mGlu3; mGlu3-LY341495
7.69Single7WIHLY27941937WIH-mGlu3; mGlu3-LY2794193
7.69Single7WIHLY27941937WIH-mGlu3; mGlu3-LY2794193
7.69Single7XW6M22 Fab7XW6-TSH-M22 Fab-ML109-Gs/β1/γ2
7.69Single7XW7K1-707XW7-TSH-K1-70
7.69Single8JCULY3414958JCU-mGlu2; mGlu3-LY341495
7.69Single8JCULY3414958JCU-mGlu2; mGlu3-LY341495
7.69Single8JCVLY3414958JCV-mGlu2; mGlu3-LY341495
7.69Single8JCVLY3414958JCV-mGlu2; mGlu3-LY341495
7.69Single8JCWLY3414958JCW-mGlu2; mGlu3-LY341495
7.69Single8JCWLY3414958JCW-mGlu2; mGlu3-LY341495
7.69Single8JCXLY3414958JCX-mGlu2; mGlu3-LY341495
7.69Single8JCXLY3414958JCX-mGlu2; mGlu3-LY341495
7.69Single8JCYLY3414958JCY-mGlu2; mGlu3-LY341495
7.69Single8JCYLY3414958JCY-mGlu2; mGlu3-LY341495
7.69Single8JCZLY3414958JCZ-mGlu2; mGlu3-LY341495
7.69Single8JCZLY3414958JCZ-mGlu2; mGlu3-LY341495
7.69Single8JD0Glutamate8JD0-mGlu2; mGlu3-Glutamate-NAM563
7.69Single8JD1Glutamate8JD1-mGlu2; mGlu3-Glutamate
7.69Single8JD1Glutamate8JD1-mGlu2; mGlu3-Glutamate
7.69Single8JD2Glutamate8JD2-mGlu2; mGlu3-Glutamate
7.69Single8JD2Glutamate8JD2-mGlu2; mGlu3-Glutamate
7.69Single8JD3Glutamate8JD3-mGlu2; mGlu3-Glutamate-HZR; PEF-Gi1/β1/γ2
7.69Single8JD3Glutamate8JD3-mGlu2; mGlu3-Glutamate-HZR; PEF-Gi1/β1/γ2
7.69Single8JD4Glutamate8JD4-mGlu2; mGlu4-Glutamate
7.69Single8JD4Glutamate8JD4-mGlu2; mGlu4-Glutamate
7.69Single8JD5Glutamate8JD5-mGlu2; mGlu4-Glutamate-BQI; HZE; PEF-Gi1/β1/γ2
7.69Single8JD5Glutamate8JD5-mGlu2; mGlu4-Glutamate-BQI; HZE; PEF-Gi1/β1/γ2
7.69Single8JD6Phosphoserine8JD6-mGlu4; mGlu4-Phosphoserine-N-(3-chlorophenyl)pyridine-2-carboxamide-Gi3/β1/γ2
7.69Single8JD6Phosphoserine8JD6-mGlu4; mGlu4-Phosphoserine-N-(3-chlorophenyl)pyridine-2-carboxamide-Gi3/β1/γ2
7.69Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
7.69Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
7.69Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
7.69Single8SZGCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-chim(NtGi1-Gq)/β1/γ2
7.69Single8SZGCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-chim(NtGi1-Gq)/β1/γ2
7.69Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/β1/γ2
7.69Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/β1/γ2
7.69Single8SZICa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZI-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi3/β1/γ2
7.69Single8SZICa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZI-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi3/β1/γ2
7.69Single8T7HQuisqualate8T7H-mGlu5; mGlu5-Quisqualate
7.69Single8T7HQuisqualate8T7H-mGlu5; mGlu5-Quisqualate
7.69Single8T8MQuisqualate8T8M-mGlu5; mGlu5-Quisqualate
7.69Single8T8MQuisqualate8T8M-mGlu5; mGlu5-Quisqualate
7.69Single8TAOQuisqualate8TAO-mGlu5; mGlu5-Quisqualate-CDPPB
7.69Single8TAOQuisqualate8TAO-mGlu5; mGlu5-Quisqualate-CDPPB
7.69Single8TQBCa; PAM VU60233268TQB-mGlu3; mGlu3-Ca; PAM VU6023326-Ca
7.69Single8TQBCa; PAM VU60233268TQB-mGlu3; mGlu3-Ca; PAM VU6023326-Ca
7.69Single8TR0LY3414958TR0-mGlu3; mGlu3-LY341495
7.69Single8TR0LY3414958TR0-mGlu3; mGlu3-LY341495
7.69Single8TR2Ca; LY3792688TR2-mGlu3; mGlu3-Ca; LY379268-Ca
7.69Single8TR2Ca; LY3792688TR2-mGlu3; mGlu3-Ca; LY379268-Ca
7.69Single8TRCLY3414958TRC-mGlu3; mGlu3-LY341495
7.69Single8TRCLY3414958TRC-mGlu3; mGlu3-LY341495
7.69Single8TRDLY3414958TRD-mGlu3; mGlu3-LY341495
7.69Single8TRDLY3414958TRD-mGlu3; mGlu3-LY341495
7.69Single8WG9(2S)-2-amino-4-phosphonobutanoic acid8WG9-mGlu4; mGlu2-(2S)-2-amino-4-phosphonobutanoic acid
7.69Single8WGBGlutammate8WGB-mGlu4; mGlu2-Glutammate-W9R-Gi3/β1/γ2
7.69Single8WGBGlutammate8WGB-mGlu4; mGlu2-Glutammate-W9R-Gi3/β1/γ2
7.69Single8WGCLY3792688WGC-mGlu4; mGlu2-LY379268
7.69Single8WGDWAG/WA68WGD-mGlu4; mGlu2-WAG/WA6
7.69Single8WGDWAG/WA68WGD-mGlu4; mGlu2-WAG/WA6
7.69Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
7.69Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
7.69Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/β1/γ2
7.69Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/β1/γ2
7.69Single8WVXNorrin8WVX-LGR4-Norrin
7.69Single8WVYNorrin8WVY-LGR4-Norrin
7.69Single8X0BQuisqualate8X0B-mGlu5; mGlu5-Quisqualate-VU0424465
7.69Single8X0BQuisqualate8X0B-mGlu5; mGlu5-Quisqualate-VU0424465
7.69Single8X0CQuisqualate8X0C-mGlu5; mGlu5-Quisqualate-VU0424465
7.69Single8X0CQuisqualate8X0C-mGlu5; mGlu5-Quisqualate-VU0424465
7.69Single8X0DQuisqualate8X0D-mGlu5; mGlu5-Quisqualate-VU0424465
7.69Single8X0DQuisqualate8X0D-mGlu5; mGlu5-Quisqualate-VU0424465
7.69Single8X0EQuisqualate8X0E-mGlu5; mGlu5-Quisqualate
7.69Single8X0EQuisqualate8X0E-mGlu5; mGlu5-Quisqualate
7.69Single8X0FQuisqualate8X0F-mGlu5; mGlu5-Quisqualate-VU0424465
7.69Single8X0FQuisqualate8X0F-mGlu5; mGlu5-Quisqualate-VU0424465
7.69Single8X0GQuisqualate8X0G-mGlu5; mGlu5-Quisqualate
7.69Single8X0GQuisqualate8X0G-mGlu5; mGlu5-Quisqualate
7.69Single8X0HQuisqualate8X0H-mGlu5; mGlu5-Quisqualate
7.69Single8X0HQuisqualate8X0H-mGlu5; mGlu5-Quisqualate
7.69Single8XJKCloprosetnol8XJK-FP-alpha-Cloprosetnol-chim(NtGi1-Gs-CtGq)/β1/γ2
7.69Single8XJOU466198XJO-TP-U46619-chim(NtGi1-Gs-CtGq)/β1/γ2
7.69Single8XUMR-spondin-28XUM-LGR4-R-spondin-2
7.69Single9ASBCa9ASB-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
7.69Single9ASBCa; Ca; Cyclomethyltryptophan; 9IG; PO49ASB-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
7.69Single9AVGCa9AVG-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs)/β1/γ2
7.69Single9AVGCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVG-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs)/β1/γ2
7.69Single9AVLCa9AVL-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi3/β2/γ2
7.69Single9AVLCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVL-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi3/β2/γ2
7.69Single9AVLCa9AVL-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi3/β2/γ2
7.69Single9AVLCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVL-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi3/β2/γ2
7.69Single9AXFCa9AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
7.69Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
7.69Single9AXFCa9AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
7.69Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
7.69Single9AYFCa9AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/β1/γ2
7.69Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/β1/γ2
7.69Single9C1PCa9C1P-CaS-Ca-Ca; Tryptophan; '6218; PO4
7.69Single9C1PCa; Tryptophan; '6218; PO49C1P-CaS-Ca-Ca; Tryptophan; '6218; PO4
7.69Single9C1PCa9C1P-CaS-Ca-Ca; Tryptophan; '6218; PO4
7.69Single9C1PCa; Tryptophan; '6218; PO49C1P-CaS-Ca-Ca; Tryptophan; '6218; PO4
7.69Single9C2FCa9C2F-CaS-Ca-Ca; Ca; Tryptophan; '6218; PO4
7.69Single9C2FCa; Ca; Tryptophan; '6218; PO49C2F-CaS-Ca-Ca; Ca; Tryptophan; '6218; PO4
7.69Single9C2FCa9C2F-CaS-Ca-Ca; Ca; Tryptophan; '6218; PO4
7.69Single9C2FCa; Ca; Tryptophan; '6218; PO49C2F-CaS-Ca-Ca; Ca; Tryptophan; '6218; PO4
7.69Single9II2Glutamate9II2-mGlu3; mGlu3-Glutamate-Arrestin2
7.69Single9II2Glutamate9II2-mGlu3; mGlu3-Glutamate-Arrestin2
7.69Single9II3Glutamate9II3-mGlu3; mGlu3-Glutamate-Arrestin2
7.69Single9II3Glutamate9II3-mGlu3; mGlu3-Glutamate-Arrestin2
7.69Consensusprostanoid_onOrthosteric Ligandtp_on fp-alpha_on
7.69Consensusprostanoid_on_gpOrthosteric Ligandtp_on_gp fp-alpha_on_gp
7.69Consensustp_onOrthosteric Ligand8XJO-TP-U46619-chim(NtGi1-Gs-CtGq)/β1/γ2
7.69Consensustp_on_gpOrthosteric Ligand8XJO-TP-U46619-chim(NtGi1-Gs-CtGq)/β1/γ2
7.41Single5EE7MK08935EE7-Glucagon-MK0893
7.41Single7CX2PGE27CX2-EP2-PGE2-Gs/β1/γ2
7.14Single7CX3Taprenepag7CX3-EP2-Taprenepag-Gs/β1/γ2
7.14Single7DD6Ca7DD6-CaS-Ca-Ca; Ca; Tryptophan
7.14Single7DD6Ca; Ca; Tryptophan7DD6-CaS-Ca-Ca; Ca; Tryptophan
7.14Single7DD6Ca7DD6-CaS-Ca-Ca; Ca; Tryptophan
7.14Single7DD6Ca; Ca; Tryptophan7DD6-CaS-Ca-Ca; Ca; Tryptophan
7.14Single7DD7Ca7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
7.14Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
7.14Single7DD7Ca7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
7.14Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
7.14Single9ASBCa9ASB-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
7.14Single9ASBCa; Ca; Cyclomethyltryptophan; 9IG; PO49ASB-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
7.14Single9AVGCa9AVG-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs)/β1/γ2
7.14Single9AVGCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVG-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs)/β1/γ2
7.14Single9AYFCa9AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/β1/γ2
7.14Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/β1/γ2
6.67Single7KNUCalcitonin gene-related peptide-17KNU-CT Like-Calcitonin gene-related peptide-1-RAMP1
6.67Single7T9MCS-17 Antibody7T9M-TSH-CS-17 Antibody
6.67Single8TLMAnti-murine CCR8 antibody8TLM-CCR8-Anti-murine CCR8 antibody
6.45Single6NIYAdrenomedullin6NIY-CT-Adrenomedullin-Gs/β1/γ2
6.25Single4A4MAll-trans-Retinal4A4M-Rhodopsin-All-trans-Retinal-Gt(CT)
6.25Single5EN0All-trans-Retinal5EN0-Rhodopsin-All-trans-Retinal-Gt(CT)
6.25Single6O3CCholesterol6O3C-SMO-SAG21k-Cholesterol
6.25Single7FIGhCG7FIG-LH-hCG-chim(NtGi1L-Gs)/β1/γ2
6.25Single7UTZTR14027UTZ-TSH-TR1402-PubChem 644078-Gs/β1/γ2
6.25Single7XW5TSH7XW5-TSH-TSH-ML109-Gs/β1/γ2
6.25Single7ZI0Cholesterol7ZI0-SMO-SAG-Cholesterol
6.25Single8GEJConstrained Epinephrine8GEJ-β2-Constrained Epinephrine-Gs/β1/γ2
6.25Single8JGBConorfamide-Tx28JGB-MRGPRX1-Conorfamide-Tx2-Gi1/β1/γ2
6.25Single8WCBCyclohexylammonium Ion8WCB-TA1-Cyclohexylammonium Ion-chim(NtGi1-Gs-CtGq)/β1/γ2
5.88Single3PXOAll-trans-Retinal3PXO-Rhodopsin-All-trans-Retinal
5.88Single5DYSAll-trans-Retinal5DYS-Rhodopsin-All-trans-Retinal
5.88Single5L7DCholesterol5L7D-SMO-Cholesterol
5.88Single7T9ITSH7T9I-TSH-TSH-Gs/β1/γ2
5.88Single8I2GGlycoprotein hormones alpha chain8I2G-FSH-Glycoprotein hormones α chain-Compound 716340-Gs/β1/γ2
5.88Single8SZICa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZI-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi3/β1/γ2
5.88Single8X9S5alpha-DHT8X9S-ADGRD1-5α-DHT-chim(NtGi1-Gs)/β1/γ2
5.56Single2HPYAll-trans-Retinal2HPY-Rhodopsin-All-trans-Retinal
5.56Single7MTBAll-trans-Retinal7MTB-Rhodopsin-All-trans-Retinal-GRK1
5.56Single7Y14Beta-Alanine7Y14-MRGPRD-β-Alanine
5.56Single8GEIConstrained Epinephrine8GEI-β2-Constrained Epinephrine-Gs/β1/γ2
5.56Single8WC5Tetramethylammonium Ion8WC5-TA1-Tetramethylammonium Ion-chim(NtGi1-Gs)/β1/γ2
5.56Consensusopsins_onOrthosteric Ligandrhodopsin_on opsin1lw_on
5.56Consensussensory_onOrthosteric Ligandopsins_on
5.26Single2ZIY11-cis-Retinal2ZIY-Rhodopsin-11-cis-Retinal
5.26Single3PQRAll-trans-Retinal3PQR-Rhodopsin-All-trans-Retinal-Gt(CT)
5.26Single6PWCNeurotensin6PWC-NTS1-Neurotensin-Arrestin2
5.26Single7F61Cholesterol7F61-H3-PF-03654746-Cholesterol
5.26Single7Y12Beta-Alanine7Y12-MRGPRD-β-Alanine-Gi1/β1/γ2
5.26Single8DPILorcaserin8DPI-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/β1/γ2
5.26Single8IU2Retinal8IU2-Opsin1LW-Retinal-Gi1/β1/γ2
5.26Single8J6QCompound 9n8J6Q-HCA2-β-Hydroxybutyrate-Compound 9n-Gi1/β1/γ2
5.26Single8JPSCCL78JPS-ACKR1-CCL7
5.26Consensusgi_opsinsOrthosteric Ligand8IU2-Opsin1LW-Retinal-Gi1/β1/γ2
5.26Consensusgi_sensoryOrthosteric Ligandgi_opsins
5.26Consensusopsin1lw_onOrthosteric Ligand8IU2-Opsin1LW-Retinal-Gi1/β1/γ2
5.26Consensusopsin1lw_on_gpOrthosteric Ligand8IU2-Opsin1LW-Retinal-Gi1/β1/γ2
5.26Consensusopsins_on_gpOrthosteric Ligandrhodopsin_on_gp opsin1lw_on_gp
5.26Consensusrhodopsin_onOrthosteric Ligand6OYA-Rhodopsin-All-trans-Retinal-Gt/β1/γ1
5.26Consensussensory_on_gpOrthosteric Ligandopsins_on_gp
5.00Single1U1911-cis-Retinal1U19-Rhodopsin-11-cis-Retinal
5.00Single2G87All-trans-Retinal2G87-Rhodopsin-All-trans-Retinal
5.00Single2I3511-cis-Retinal2I35-Rhodopsin-11-cis-Retinal
5.00Single3AYMAll-trans-Retinal3AYM-Rhodopsin-All-trans-Retinal
5.00Single7DFLHistamine7DFL-H1-Histamine-chim(NtGi1L-Gq)/β1/γ2
5.00Single7V68Iperoxo7V68-M4-Iperoxo-PubChem 57664406-Gi1/β1/γ2
5.00Single7XKFBeta-Hydroxyandrosterone7XKF-ADGRG2-β-Hydroxyandrosterone-Gs/β1/γ2
5.00Single8J6PCompound 9n8J6P-HCA2-Niacin-Compound 9n-Gi1/β1/γ2
5.00Single8JHYCompound 9n8JHY-HCA2-Compound 9n-Gi1/β1/γ2
5.00Single8JIICompound 9n8JII-HCA2-Niacin-Compound 9n-Gi1/β1/γ2
5.00Single8YN2Histamine8YN2-H1-Histamine-chim(NtGi1L-Gs-CtGq)/β1/γ2
5.00Consensush1_onOrthosteric Ligand7DFL-H1-Histamine-chim(NtGi1L-Gq)/β1/γ2
4.76Single2Z7311-cis-Retinal2Z73-Rhodopsin-11-cis-Retinal
4.76Single3AYN9-cis-Retinal3AYN-Rhodopsin-9-cis-Retinal
4.76Single4XNVBPTU4XNV-P2Y1-BPTU
4.76Single7WV9ZCZ0117WV9-CB1-CP55940-ZCZ011-Gi2/β1/γ2
4.55Single7VODCariprazine7VOD-5-HT2A-Cariprazine
4.55Single8HNMVUF112228HNM-CXCR3-VUF11222-Gi1/β1/γ2
4.55Single8IYXYL-3658IYX-GPR34-YL-365
4.55Single8W8BSEP-3638568W8B-5-HT1A-SEP-363856-Gi1/β1/γ2
4.17Single5CGCHTL142425CGC-mGlu5-HTL14242
4.17Single8GDCPGE28GDC-EP3-PGE2-Gi1/β1/γ2
4.17Single8X0CVU04244658X0C-mGlu5; mGlu5-Quisqualate-VU0424465
4.17Single8X0CVU04244658X0C-mGlu5; mGlu5-Quisqualate-VU0424465
4.17Single8YNSSNAP-948478YNS-MCH1-SNAP-94847
3.70Single5CGDHTL142425CGD-mGlu5-HTL14242
3.45Single8XFTR-spondin-28XFT-LGR4-R-spondin-2-ZNRF3
3.45Single8Y69R-spondin-28Y69-LGR4-R-spondin-2-Cholesterol-ZNRF3
3.33Single7SHEPI; PE7SHE-GPR158-PI; PE
3.23Single8WVUR-spondin-18WVU-LGR4-R-spondin-1-RNF43
3.23Single8Y69R-spondin-28Y69-LGR4-R-spondin-2-Cholesterol-ZNRF3
3.12Single8XFPR-spondin-28XFP-LGR4-R-spondin-2-ZNRF3
2.86Single8XFSR-spondin-28XFS-LGR4-R-spondin-2-ZNRF3

PDB Summary
PDB 7YU5
Class A
SubFamily Lipid
Type Lysophospholipid
SubType LPA1
Species Homo Sapiens
Ligand ONO-0740556
Other Ligand(s) -
Protein Partners Gi1/Beta1/Gamma2
PDB Resolution 3.7
Date 2022-10-05
D.O.I. 10.1038/s41467-022-33121-2
Net Summary
Imin 2.95
Number of Linked Nodes 862
Number of Links 1068
Number of Hubs 186
Number of Links mediated by Hubs 677
Number of Communities 25
Number of Nodes involved in Communities 241
Number of Links involved in Communities 360
Path Summary
Number Of Nodes in MetaPath 93
Number Of Links MetaPath 92
Number of Shortest Paths 4179126
Length Of Smallest Path 3
Average Path Length 45.7259
Length of Longest Path 77
Minimum Path Strength 1.145
Average Path Strength 6.72384
Maximum Path Strength 31.16
Minimum Path Correlation 0.7
Average Path Correlation 0.993191
Maximum Path Correlation 1
Minimum % Of Corr. Nodes 1.75439
Average % Of Corr. Nodes 30.5609
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 51.3454
Maximum Path Hubs % 100
AnnotationTypeLinks
Gene OntologyMolecular Function• cytoskeletal protein binding   • spectrin binding   • protein-containing complex binding   • protein binding   • binding   • enzyme binding   • GTPase binding   • phosphoric ester hydrolase activity   • alkylglycerophosphoethanolamine phosphodiesterase activity   • hydrolase activity, acting on ester bonds   • phosphoric diester hydrolase activity   • hydrolase activity   • catalytic activity   • pyrophosphatase activity   • GTPase activity   • ribonucleoside triphosphate phosphatase activity   • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides   • hydrolase activity, acting on acid anhydrides   • signaling receptor complex adaptor activity   • protein-macromolecule adaptor activity   • molecular adaptor activity   • signaling adaptor activity   • positive regulation of cytosolic calcium ion concentration   • biological regulation   • regulation of biological quality   • multicellular organismal process   • system process   • sensory perception of chemical stimulus   • sensory perception   • nervous system process   • sensory perception of taste   • developmental process   • sensory organ development   • eye development   • animal organ development   • retina development in camera-type eye
Gene OntologyBiological Process• positive regulation of cytosolic calcium ion concentration   • biological regulation   • regulation of biological quality   • multicellular organismal process   • system process   • sensory perception of chemical stimulus   • sensory perception   • nervous system process   • sensory perception of taste   • developmental process   • sensory organ development   • eye development   • animal organ development   • retina development in camera-type eye   • visual system development   • multicellular organism development   • camera-type eye development   • anatomical structure development   • sensory system development   • system development   • response to decreased oxygen levels   • cellular response to stimulus   • response to stimulus   • cellular response to oxygen levels   • cellular response to hypoxia   • cellular response to decreased oxygen levels   • cellular response to chemical stimulus   • cellular response to stress   • response to hypoxia   • response to stress   • response to chemical   • response to oxygen levels   • response to abiotic stimulus   • cellular process   • cell population proliferation   • regulation of biological process   • regulation of cellular process   • signaling   • phospholipase C-activating G protein-coupled receptor signaling pathway   • cell communication   • G protein-coupled receptor signaling pathway   • signal transduction   • muscle cell apoptotic process   • striated muscle cell apoptotic process   • apoptotic process   • cell death   • programmed cell death   • cardiac muscle cell apoptotic process   • protein-containing complex   • extrinsic component of plasma membrane   • catalytic complex   • plasma membrane protein complex   • cytoplasmic side of membrane   • membrane   • plasma membrane   • membrane protein complex   • heterotrimeric G-protein complex   • side of membrane   • cell periphery   • cellular anatomical structure   • cytoplasmic side of plasma membrane   • GTPase complex
Gene OntologyCellular Component• protein-containing complex   • extrinsic component of plasma membrane   • catalytic complex   • plasma membrane protein complex   • cytoplasmic side of membrane   • membrane   • plasma membrane   • membrane protein complex   • heterotrimeric G-protein complex   • side of membrane   • cell periphery   • cellular anatomical structure   • cytoplasmic side of plasma membrane   • GTPase complex   • extrinsic component of membrane   • extrinsic component of cytoplasmic side of plasma membrane   • photoreceptor inner segment   • somatodendritic compartment   • cell projection   • dendrite   • dendritic tree   • neuron projection   • plasma membrane bounded cell projection   • intracellular anatomical structure   • cytoplasm   • membrane-bounded organelle   • non-motile cilium   • 9+0 non-motile cilium   • cilium   • photoreceptor outer segment   • photoreceptor cell cilium   • organelle   • ciliary membrane   • photoreceptor outer segment membrane   • bounding membrane of organelle   • plasma membrane region   • organelle membrane   • cell projection membrane   • synapse   • cell junction   • cell body   • D2 dopamine receptor binding   • protein binding   • binding   • signaling receptor binding   • G protein-coupled receptor binding   • dopamine receptor binding   • phosphorus-oxygen lyase activity   • enzyme regulator activity   • cyclase regulator activity   • molecular function regulator activity   • cyclase activity   • adenylate cyclase regulator activity   • lyase activity   • catalytic activity   • adenylate cyclase activity   • guanyl nucleotide binding   • GTP binding   • nucleotide binding   • guanyl ribonucleotide binding   • purine ribonucleotide binding   • purine ribonucleoside triphosphate binding   • nucleoside phosphate binding   • ion binding   • purine nucleotide binding   • anion binding   • heterocyclic compound binding   • carbohydrate derivative binding   • ribonucleotide binding   • small molecule binding   • cation binding   • magnesium ion binding   • metal ion binding   • GDP binding   • G protein-coupled serotonin receptor binding   • protein-containing complex binding   • G-protein beta/gamma-subunit complex binding   • pyrophosphatase activity   • GTPase activity   • G protein activity   • ribonucleoside triphosphate phosphatase activity   • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides   • hydrolase activity   • hydrolase activity, acting on acid anhydrides   • cellular response to stimulus   • regulation of biological process   • regulation of cellular process   • response to stimulus   • signaling   • biological regulation   • adenylate cyclase-inhibiting serotonin receptor signaling pathway   • G protein-coupled serotonin receptor signaling pathway   • cell communication   • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway   • adenylate cyclase-modulating G protein-coupled receptor signaling pathway   • G protein-coupled receptor signaling pathway   • cellular process   • signal transduction   • response to hormone   • response to chemical   • response to endogenous stimulus   • response to peptide hormone   • response to oxygen-containing compound   • response to nitrogen compound   • cell division   • leukocyte migration   • immune system process   • mononuclear cell migration   • lymphocyte migration   • cell migration   • T cell migration   • cell motility   • regulation of steroid biosynthetic process   • regulation of cholesterol biosynthetic process   • regulation of cholesterol metabolic process   • steroid metabolic process   • regulation of lipid metabolic process   • sterol metabolic process   • positive regulation of biological process   • cholesterol metabolic process   • lipid biosynthetic process   • alcohol metabolic process   • regulation of primary metabolic process   • positive regulation of metabolic process   • regulation of small molecule metabolic process   • positive regulation of biosynthetic process   • positive regulation of lipid metabolic process   • small molecule metabolic process   • steroid biosynthetic process   • positive regulation of cellular process   • regulation of biosynthetic process   • secondary alcohol biosynthetic process   • regulation of alcohol biosynthetic process   • small molecule biosynthetic process   • regulation of steroid metabolic process   • cholesterol biosynthetic process   • positive regulation of cholesterol biosynthetic process   • primary metabolic process   • secondary alcohol metabolic process   • positive regulation of steroid biosynthetic process   • biosynthetic process   • sterol biosynthetic process   • positive regulation of lipid biosynthetic process   • regulation of sterol biosynthetic process   • alcohol biosynthetic process   • positive regulation of cholesterol metabolic process   • positive regulation of steroid metabolic process   • metabolic process   • regulation of lipid biosynthetic process   • positive regulation of small molecule metabolic process   • regulation of metabolic process   • positive regulation of alcohol biosynthetic process   • positive regulation of sterol biosynthetic process   • lipid metabolic process   • regulation of cytoskeleton organization   • regulation of cellular component organization   • microtubule cytoskeleton organization   • regulation of mitotic spindle organization   • mitotic cell cycle   • cellular component organization   • cell cycle   • cellular component organization or biogenesis   • regulation of cell cycle   • microtubule cytoskeleton organization involved in mitosis   • spindle organization   • cell cycle process   • regulation of cell cycle process   • regulation of microtubule-based process   • regulation of spindle organization   • regulation of organelle organization   • mitotic spindle organization   • organelle organization   • mitotic cell cycle process   • microtubule-based process   • cytoskeleton organization   • regulation of microtubule cytoskeleton organization   • protein localization   • positive regulation of protein localization to cell periphery   • regulation of localization   • protein localization to cell periphery   • cellular localization   • regulation of protein localization   • positive regulation of protein localization to cell cortex   • regulation of protein localization to cell periphery   • localization   • regulation of cellular localization   • regulation of protein localization to cell cortex   • cellular macromolecule localization   • macromolecule localization   • positive regulation of protein localization   • protein localization to cell cortex   • response to ketone   • response to prostaglandin   • response to lipid   • response to alcohol   • response to prostaglandin E   • cellular response to forskolin   • cellular response to oxygen-containing compound   • cellular response to chemical stimulus   • cellular response to alcohol   • response to forskolin   • cellular response to lipid   • cellular response to ketone   • midbody   • nucleus   • membrane-enclosed lumen   • intracellular membraneless organelle   • intracellular membrane-bounded organelle   • nucleolus   • intracellular organelle lumen   • intracellular organelle   • organelle lumen   • membraneless organelle   • nuclear lumen   • cell cortex   • extracellular exosome   • extracellular vesicle   • extracellular organelle   • extracellular region   • extracellular space   • vesicle   • extracellular membrane-bounded organelle   • centrosome   • microtubule organizing center   • cytoskeleton   • microtubule cytoskeleton   • centriolar satellite   • cytosol   • nucleoplasm   • vacuolar membrane   • lytic vacuole   • vacuole   • lytic vacuole membrane   • lysosomal membrane   • lysosome   • Golgi apparatus   • endomembrane system   • ciliary basal body   • G-protein beta-subunit binding   • cellular response to nitrogen compound   • response to dopamine   • cellular response to dopamine   • response to monoamine   • response to catecholamine   • adenylate cyclase-activating dopamine receptor signaling pathway   • cellular response to catecholamine stimulus   • G protein-coupled dopamine receptor signaling pathway   • adenylate cyclase-activating G protein-coupled receptor signaling pathway   • cellular response to monoamine stimulus   • cellular response to prostaglandin stimulus   • cellular response to endogenous stimulus   • cellular response to prostaglandin E stimulus   • cellular response to hormone stimulus   • phospholipid binding   • lipid binding   • lysophosphatidic acid binding   • bioactive lipid receptor activity   • molecular transducer activity   • G protein-coupled receptor activity   • transmembrane signaling receptor activity   • signaling receptor activity   • lysophosphatidic acid receptor activity   • G-protein alpha-subunit binding   • PDZ domain binding   • protein domain specific binding   • developmental process   • multicellular organism development   • multicellular organismal process   • nerve development   • cranial nerve development   • anatomical structure development   • optic nerve development   • nervous system development   • system development   • positive regulation of programmed cell death   • regulation of apoptotic process   • regulation of programmed cell death   • cell death   • positive regulation of apoptotic process   • apoptotic process   • programmed cell death   • head development   • animal organ development   • brain development   • cerebellum development   • central nervous system development   • metencephalon development   • hindbrain development   • regulation of developmental process   • cellular developmental process   • cell projection organization   • positive regulation of dendritic spine development   • cell development   • regulation of dendritic spine development   • neuron projection development   • positive regulation of developmental process   • neurogenesis   • neuron differentiation   • dendrite development   • cell differentiation   • dendritic spine development   • plasma membrane bounded cell projection organization   • generation of neurons   • neuron development   • regulation of neuron projection development   • negative regulation of biological process   • negative regulation of cellular process   • negative regulation of cell projection organization   • negative regulation of cellular component organization   • regulation of cell projection organization   • negative regulation of neuron projection development   • regulation of plasma membrane bounded cell projection organization   • cell chemotaxis   • chemotaxis   • response to external stimulus   • taxis   • locomotion   • phospholipase C-activating G protein-coupled receptor signaling pathway   • transport   • regulation of transport   • regulation of synaptic vesicle cycle   • synaptic vesicle cycle   • regulation of vesicle-mediated transport   • establishment of localization   • vesicle-mediated transport   • vesicle-mediated transport in synapse   • establishment of localization in cell   • import into cell   • receptor internalization   • postsynaptic neurotransmitter receptor internalization   • regulation of receptor internalization   • regulation of postsynaptic neurotransmitter receptor internalization   • regulation of biological quality   • regulation of endocytosis   • regulation of receptor-mediated endocytosis   • protein-containing complex localization   • neurotransmitter receptor internalization   • regulation of postsynaptic membrane neurotransmitter receptor levels   • postsynaptic endocytosis   • endocytosis   • receptor-mediated endocytosis   • corpus callosum development   • forebrain development   • telencephalon development   • positive regulation of cytosolic calcium ion concentration   • positive regulation of cell communication   • positive regulation of signal transduction   • positive regulation of canonical NF-kappaB signal transduction   • regulation of signal transduction   • intracellular signal transduction   • positive regulation of response to stimulus   • regulation of intracellular signal transduction   • intracellular signaling cassette   • regulation of signaling   • positive regulation of intracellular signal transduction   • canonical NF-kappaB signal transduction   • regulation of response to stimulus   • regulation of cell communication   • regulation of canonical NF-kappaB signal transduction   • positive regulation of signaling   • cellular component biogenesis   • bleb assembly   • cellular component assembly   • plasma membrane bounded cell projection assembly   • cell projection assembly   • small GTPase-mediated signal transduction   • regulation of small GTPase mediated signal transduction   • Rho protein signal transduction   • regulation of Rho protein signal transduction   • positive regulation of Rho protein signal transduction   • positive regulation of small GTPase mediated signal transduction   • positive regulation of locomotion   • regulation of cell motility   • positive regulation of smooth muscle cell chemotaxis   • regulation of smooth muscle cell chemotaxis   • regulation of response to external stimulus   • regulation of smooth muscle cell migration   • positive regulation of smooth muscle cell migration   • positive regulation of chemotaxis   • positive regulation of cell migration   • muscle cell migration   • positive regulation of response to external stimulus   • positive regulation of cell motility   • smooth muscle cell chemotaxis   • regulation of cell migration   • regulation of chemotaxis   • smooth muscle cell migration   • regulation of locomotion   • negative regulation of organelle assembly   • negative regulation of plasma membrane bounded cell projection assembly   • cilium assembly   • cilium organization   • organelle assembly   • regulation of cell projection assembly   • regulation of cellular component biogenesis   • regulation of plasma membrane bounded cell projection assembly   • regulation of cilium assembly   • negative regulation of organelle organization   • regulation of organelle assembly   • negative regulation of cilium assembly   • cellular response to oxygen levels   • response to oxygen levels   • response to abiotic stimulus   • regulation of cell shape   • cell morphogenesis   • regulation of cell morphogenesis   • anatomical structure morphogenesis   • regulation of anatomical structure morphogenesis   • negative regulation of signaling   • negative regulation of intracellular signal transduction   • negative regulation of cAMP/PKA signal transduction   • negative regulation of cell communication   • cAMP/PKA signal transduction   • negative regulation of response to stimulus   • negative regulation of signal transduction   • regulation of cAMP/PKA signal transduction   • oligodendrocyte development   • glial cell development   • gliogenesis   • oligodendrocyte differentiation   • glial cell differentiation   • positive regulation of MAPK cascade   • regulation of MAPK cascade   • MAPK cascade   • myelination   • axon ensheathment   • ensheathment of neurons   • response to 1-oleoyl-sn-glycerol 3-phosphate   • response to organophosphorus   • cellular response to 1-oleoyl-sn-glycerol 3-phosphate   • positive regulation of organelle organization   • regulation of actin filament-based process   • positive regulation of cellular component organization   • regulation of actin filament bundle assembly   • positive regulation of actin filament bundle assembly   • actin filament bundle organization   • positive regulation of stress fiber assembly   • actin filament-based process   • stress fiber assembly   • regulation of actin filament organization   • actin cytoskeleton organization   • actomyosin structure organization   • positive regulation of cellular component biogenesis   • positive regulation of cytoskeleton organization   • actin filament organization   • positive regulation of supramolecular fiber organization   • regulation of stress fiber assembly   • contractile actin filament bundle assembly   • regulation of actomyosin structure organization   • regulation of actin cytoskeleton organization   • actin filament bundle assembly   • regulation of supramolecular fiber organization   • supramolecular fiber organization   • postsynapse   • postsynaptic membrane   • synaptic membrane   • presynapse   • presynaptic membrane   • glutamatergic synapse   • dendritic shaft   • neuron spine   • dendritic spine   • neuronal cell body   • cell surface   • GABA-ergic synapse   • endosome   • intracellular vesicle   • cytoplasmic vesicle
SCOP2Domain Identifier• Ras-like P-loop GTPases   • Transducin (heterotrimeric G protein), gamma chain   • G protein-coupled receptor-like
SCOP2Family Identifier• Ras-like P-loop GTPases   • Transducin (heterotrimeric G protein), gamma chain   • G protein-coupled receptor-like
Membrane Protein Annotations-• Orientations of Proteins in Membranes database (OPM)   • Protein Data Bank of Transmembrane Proteins (PDBTM)   • MemProtMD


Details about the values in these tables can be found in the corresponding documentation page .
CodeK6L
PDB ResiduesL:L:?1
Environment DetailsOpen EMBL-EBI Page
CodeK6L
Name[(2~{R})-2-[5-(2-hexylphenyl)pentanoylamino]-3-oxidanyl-propyl] dihydrogen phosphate
Synonyms
Identifier
FormulaC20 H34 N O6 P
Molecular Weight415.461
SMILES
PubChem141702624
Formal Charge0
Total Atoms62
Total Chiral Atoms1
Total Bonds62
Total Aromatic Bonds6

PDBsumOpen PDBsum Page
ChainB
ProteinG Protein β Sub unit
UniProtP54311
Sequence
>7YU5_Chain_B
ELDQLRQEA EQLKNQIRD ARKACADAT LSQITNNID PVGRIQMRT 
RRTLRGHLA KIYAMHWGT DSRLLVSAS QDGKLIIWD SYTTNKVHA 
IPLRSSWVM TCAYAPSGN YVACGGLDN ICSIYNLKT REGNVRVSR 
ELAGHTGYL SCCRFLDDN QIVTSSGDT TCALWDIET GQQTTTFTG 
HTGDVMSLS LAPDTRLFV SGACDASAK LWDVREGMC RQTFTGHES 
DINAICFFP NGNAFATGS DDATCRLFD LRADQELMT YSHDNIICG 
ITSVSFSKS GRLLLAGYD DFNCNVWDA LKADRAGVL AGHDNRVSC 
LGVTDDGMA VATGSWDSF LKIWN


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainA
ProteinG Protein α Sub unit
UniProtP63096
Sequence
>7YU5_Chain_A
SAEDKAAVE RSKMIDRNL REDGEKAAR EVKLLLLGA GESGKSTIV 
KQMKTGIVE THFTFKDLH FKMFDVGGQ RSERKKWIH CFEGVTAII 
FCVALSDYD LVLAEDEEM NRMHESMKL FDSICNNKW FTDTSIILF 
LNKKDLFEE KIKKSPLTI CYPEYAGSN TYEEAAAYI QCQFEDLNK 
RKDTKEIYT HFTCATDTK NVQFVFDAV TDVIIKNNL KDCGLF


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainG
ProteinG Protein γ Sub unit
UniProtP63212
Sequence
>7YU5_Chain_G
SIAQARKLV EQLKMEANI DRIKVSKAA ADLMAYCEA HAKEDPLLT 
PVPASENPF


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainR
ProteinReceptor
UniProtQ92633
Sequence
>7YU5_Chain_R
QCFYNESIA FFYNRSGKH LATEWNTVS KLVMGLGIT VCIFIMLAN 
LLVMVAIYV NRRFHFPIY YLMANLAAA DFFAGLAYF YLMFNTGPN 
TRRLTVSTW LLRQGLIDT SLTASVANL LAIAIERHI TVFRMQLHT 
RMSNRRVVV VIVVIWTMA IVMGAIPSV GWNCICDIE NCSNMAPLY 
SDSYLVFWA IFNLVTFVV MVVLYAHIF GYVRQRTMR MDTMMSLLK 
TVVIVLGAF IICWTPGLV LLLLDVCCP QCDVLAYEK FFLLLAEFN 
SAMNPIIYS YRDKEMSAT FR


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  




This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
9IZGALipidLysophospholipidLPA1Homo sapiensNKP-chim(NtGi1-Gs-CtGq)/β1/γ23.042025-01-0110.1016/j.jsb.2024.108164
9IZG (No Gprot) ALipidLysophospholipidLPA1Homo sapiensNKP-3.042025-01-0110.1016/j.jsb.2024.108164
9IZHALipidLysophospholipidLPA1Homo sapiensLPA-chim(NtGi2-G13)/β1/γ23.042025-01-01doi.org/10.1016/j.jsb.2024.108164
9IZH (No Gprot) ALipidLysophospholipidLPA1Homo sapiensLPA-3.042025-01-01doi.org/10.1016/j.jsb.2024.108164
9J5VALipidLysophospholipidLPA1Homo sapiensCpY-Gi1/β1/γ22.862024-11-2710.1038/s42003-024-07152-y
9J5V (No Gprot) ALipidLysophospholipidLPA1Homo sapiensCpY-2.862024-11-2710.1038/s42003-024-07152-y
9IZFALipidLysophospholipidLPA1Homo sapiensNKP-Gi1/β1/γ23.142025-01-0110.1016/j.jsb.2024.108164
9IZF (No Gprot) ALipidLysophospholipidLPA1Homo sapiensNKP-3.142025-01-0110.1016/j.jsb.2024.108164
7YU4ALipidLysophospholipidLPA1Homo sapiensONO-0740556--3.72022-10-0510.1038/s41467-022-33121-2
7YU8ALipidLysophospholipidLPA1Homo sapiensONO-0740556-Gi1/β1/γ25.62022-10-0510.1038/s41467-022-33121-2
7YU8 (No Gprot) ALipidLysophospholipidLPA1Homo sapiensONO-0740556-5.62022-10-0510.1038/s41467-022-33121-2
7YU7ALipidLysophospholipidLPA1Homo sapiensONO-0740556-Gi1/β1/γ24.52022-10-0510.1038/s41467-022-33121-2
7YU7 (No Gprot) ALipidLysophospholipidLPA1Homo sapiensONO-0740556-4.52022-10-0510.1038/s41467-022-33121-2
7YU6ALipidLysophospholipidLPA1Homo sapiensONO-0740556-Gi1/β1/γ23.92022-10-0510.1038/s41467-022-33121-2
7YU6 (No Gprot) ALipidLysophospholipidLPA1Homo sapiensONO-0740556-3.92022-10-0510.1038/s41467-022-33121-2
7YU5 (No Gprot) ALipidLysophospholipidLPA1Homo sapiensONO-0740556-3.72022-10-0510.1038/s41467-022-33121-2
7YU3ALipidLysophospholipidLPA1Homo sapiensONO-0740556-Gi1/β1/γ23.52022-10-0510.1038/s41467-022-33121-2
7YU3 (No Gprot) ALipidLysophospholipidLPA1Homo sapiensONO-0740556-3.52022-10-0510.1038/s41467-022-33121-2
7TD2ALipidLysophospholipidLPA1Homo sapiensLPA-Gi1/β1/γ23.112022-02-0910.1038/s41467-022-28417-2
7TD2 (No Gprot) ALipidLysophospholipidLPA1Homo sapiensLPA-3.112022-02-0910.1038/s41467-022-28417-2
7TD1ALipidLysophospholipidLPA1Homo sapiensLPA-Gi1/β1/γ23.082022-02-0910.1038/s41467-022-28417-2
7TD1 (No Gprot) ALipidLysophospholipidLPA1Homo sapiensLPA-3.082022-02-0910.1038/s41467-022-28417-2
7TD0ALipidLysophospholipidLPA1Homo sapiensLPA-Gi1/β1/γ22.832022-02-0910.1038/s41467-022-28417-2
7TD0 (No Gprot) ALipidLysophospholipidLPA1Homo sapiensLPA-2.832022-02-0910.1038/s41467-022-28417-2
4Z36ALipidLysophospholipidLPA1Homo sapiensONO-3080573--2.92015-06-0310.1016/j.cell.2015.06.002
4Z35ALipidLysophospholipidLPA1Homo sapiensONO-9910539--2.92015-06-0310.1016/j.cell.2015.06.002
4Z34ALipidLysophospholipidLPA1Homo sapiensONO-9780307--32015-06-0310.1016/j.cell.2015.06.002




You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download 7YU5.zip



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