Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg Int. Strength Num Of Links Community ConSurf
1A:A:E27 7.0175406
2A:A:K28 4.1725404
3A:A:Y37 9.5975424
4A:A:L45 4.766676198
5A:A:F219 5.103336138
6A:A:H220 5.295407
7A:A:M221 4.92408
8A:A:F222 10.28527
9A:A:D223 3.814199
10A:A:R232 4.68754118
11A:A:K233 6.105419
12A:A:W234 8.5245119
13A:A:F238 10.615409
14A:A:N254 7.59754229
15A:A:R265 8.55409
16A:A:L272 4.8454118
17A:A:F273 4.433336219
18A:A:W277 7.6765216
19A:A:W281 7.05425
20A:A:F290 4.905499
21A:A:K307 5.82406
22A:A:F312 4.512508
23A:A:F315 12.1875406
24A:A:P321 3.71333645
25A:A:E330 13.6025443
26A:A:Y339 5.8025443
27A:A:R342 6.726544
28A:A:D343 5.4875443
29A:A:F345 8.6025408
30A:A:L346 5.055444
31A:A:Y358 6.36254254
32A:A:F363 9.4025445
33A:A:T364 6.92499
34A:A:D368 3.83499
35A:A:N371 6.412599
36A:A:R374 5.0825494
37A:A:F376 5.8065138
38A:A:R385 10.124255
39A:A:H387 4.72754148
40A:A:Y391 5.6975404
41B:B:H54 9.4945129
42B:B:Y59 9.856528
43B:B:W63 6.28833607
44B:B:R68 9.405435
45B:B:L69 4.715435
46B:B:Q75 7.4525429
47B:B:D76 5.975409
48B:B:W82 10.4265129
49B:B:D83 10.0075438
50B:B:Y85 9.465434
51B:B:N88 8.22437
52B:B:K89 9.545409
53B:B:W99 12.3875429
54B:B:Y105 4.72429736
55B:B:Y111 5.63404
56B:B:I123 4.3325456
57B:B:Y124 6.7225266
58B:B:H142 8.43667659
59B:B:Y145 6.35618
60B:B:F151 4.7475409
61B:B:L152 4.255403
62B:B:I157 3.92457
63B:B:T159 5.854559
64B:B:D163 8.055459
65B:B:C166 4.4775468
66B:B:W169 9.69167658
67B:B:Q176 7.3025454
68B:B:F180 7.582567
69B:B:H183 8.286569
70B:B:D186 6.5825419
71B:B:V187 4.47569
72B:B:F199 9.3425469
73B:B:K209 9.7575466
74B:B:W211 10.36568
75B:B:D212 8.84279
76B:B:F222 8.31418
77B:B:H225 11.768519
78B:B:S227 4.165416
79B:B:D228 7.8025419
80B:B:F234 6.5775405
81B:B:F235 7.5465156
82B:B:P236 5.66754157
83B:B:F241 8.8025416
84B:B:D247 9.4675419
85B:B:T249 7.1725416
86B:B:R251 9.625618
87B:B:F253 7.59833616
88B:B:D258 10.115417
89B:B:M262 4.565404
90B:B:Y264 5.308505
91B:B:F278 6.39754157
92B:B:Y289 9.424167
93B:B:D290 5.868526
94B:B:C294 4.295405
95B:B:N295 7.1645166
96B:B:W297 4.38754168
97B:B:K301 3.955405
98B:B:H311 10.0125109
99B:B:R314 11.265428
100B:B:L318 4.0175406
101B:B:M325 5.7475405
102B:B:T329 6.81408
103B:B:W332 12.6183629
104B:B:D333 8.1154109
105B:B:F335 8.3975404
106B:B:K337 8.52754106
107B:B:W339 8.525109
108G:G:Y40 10.32754156
109G:G:D48 6.2125409
110G:G:N59 5.8825439
111G:G:F61 6.00875838
112R:R:L53 4.5525406
113R:R:F61 7.3545176
114R:R:R63 5.6265176
115R:R:F71 4.5408
116R:R:D79 7.606509
117R:R:L80 4.9954297
118R:R:V87 4.634287
119R:R:W99 10.325317
120R:R:F101 7.4625405
121R:R:W109 5.625405
122R:R:L124 4.72578
123R:R:D130 7.58754148
124R:R:Y132 7.438508
125R:R:I135 5.4375409
126R:R:F139 6.696136
127R:R:Y141 8.0554147
128R:R:L145 5.9154147
129R:R:W158 4.9925409
130R:R:F166 6.6925484
131R:R:Y174 6.93585
132R:R:T189 5.82254324
133R:R:F193 6.9775404
134R:R:Y199 5.938586
135R:R:F208 11.312508
136R:R:M215 4.0125478
137R:R:Y219 5.128509
138R:R:F282 5.684579
139R:R:W286 8.27143778
140R:R:L287 5.2325406
141R:R:F289 8.24676
142R:R:F290 9.375477
143R:R:W313 6.6925405
144R:R:Y316 12.0725476
145R:R:Y326 4.324509
146R:R:F332 6.671676309
147L:L:?1 8.4041070
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
1B:B:H54 B:B:W82 73.83999.52YesYes1299
2B:B:H54 B:B:S74 74.15699.76YesNo1299
3B:B:D76 B:B:S74 74.51234.42YesNo099
4B:B:D76 B:B:L55 75.907510.86YesNo096
5A:A:Y37 B:B:L55 75.81484.69YesNo246
6A:A:R42 A:A:Y37 77.141519.55NoYes294
7A:A:F222 A:A:R42 77.36973.21YesNo279
8A:A:Q384 R:R:Q229 77.727110.24NoNo067
9A:A:R385 R:R:Q229 78.20898.18YesNo057
10A:A:R385 A:A:Y358 83.95647.2YesYes2554
11A:A:Y358 R:R:E237 84.37597.86YesNo043
12A:A:T350 R:R:E237 84.56197.06NoNo043
13A:A:T350 R:R:R239 84.65497.76NoNo044
14A:A:L346 R:R:R239 89.48957.29YesNo044
15A:A:L346 A:A:S349 99.16396.01YesNo047
16A:A:S349 A:A:W277 49.7673.71NoYes076
17A:A:F273 A:A:W277 50.01537.02YesYes2196
18A:A:F246 A:A:F273 99.50253.22NoYes099
19A:A:F246 A:A:L272 1006.09NoYes098
20A:A:L272 A:A:L46 49.82444.15YesNo1188
21A:A:L46 A:A:W234 49.82183.42NoYes1189
22A:A:F238 A:A:W234 98.97165.01YesYes099
23A:A:F238 B:B:W99 97.888214.03YesYes099
24A:A:F222 B:B:W99 78.400223.05YesYes279
25A:A:C359 A:A:S349 49.48185.16NoNo057
26A:A:C359 A:A:F273 49.50924.19NoYes059
27A:A:L272 A:A:R232 50.11514.86YesYes1188
28A:A:R232 A:A:W234 49.82139YesYes1189
29A:A:F340 A:A:Y318 13.267313.41NoNo076
30A:A:D343 A:A:Y318 13.50199.2YesNo436
31A:A:L346 A:A:R342 10.58613.64YesYes444
32A:A:Q227 B:B:T143 45.9855.67NoNo095
33B:B:D163 B:B:T143 46.110910.12YesNo095
34B:B:D163 B:B:H142 46.8437.56YesYes599
35B:B:H142 B:B:T159 47.19885.48YesYes599
36B:B:C149 B:B:T159 51.37885.07NoYes089
37B:B:C149 B:B:T102 51.5025.07NoNo088
38B:B:C148 B:B:T102 51.62523.38NoNo068
39B:B:C148 B:B:R150 51.74836.96NoNo066
40B:B:H62 B:B:R150 57.461916.93NoNo066
41B:B:H62 B:B:Y105 57.5823.27NoYes066
42B:B:L69 B:B:Y105 60.56115.86YesYes356
43A:A:Q227 B:B:G144 45.58524.93NoNo2098
44B:B:G144 B:B:G162 45.48062.11NoNo089
45B:B:G162 B:B:Y145 45.35435.79NoYes098
46A:A:K233 B:B:Y145 44.42674.78YesYes198
47A:A:K233 B:B:D228 44.34186.91YesYes199
48B:B:Q75 B:B:W99 27.69538.76YesYes299
49B:B:K57 B:B:Q75 13.64444.07NoYes299
50B:B:K57 B:B:W332 13.5126.69NoYes299
51B:B:R314 B:B:W332 25.937717.99YesYes289
52B:B:Q75 B:B:Y59 13.782112.4YesYes298
53B:B:W332 B:B:Y59 13.513314.47YesYes298
54B:B:D290 B:B:R314 24.795710.72YesYes268
55A:A:H387 A:A:I383 74.65633.98YesNo088
56A:A:I383 R:R:P138 73.90145.08NoNo088
57A:A:Q384 R:R:P138 73.99796.32NoNo068
58A:A:H387 R:R:A134 57.30344.39YesNo1488
59A:A:H387 R:R:Y141 17.15524.36YesYes1487
60A:A:Y391 R:R:A134 57.23544YesNo048
61A:A:L393 A:A:Y391 55.75724.69NoYes084
62R:R:L275 R:R:Y219 54.77184.69NoYes089
63A:A:L393 R:R:L275 55.28774.15NoNo088
64B:B:D228 B:B:S227 43.95172.94YesYes196
65B:B:S227 B:B:S245 17.45564.89YesNo169
66B:B:H225 B:B:S245 17.322311.16YesNo199
67B:B:H225 B:B:T243 16.49968.21YesNo198
68B:B:F253 B:B:T243 16.23239.08YesNo168
69B:B:F222 B:B:F253 18.571812.86YesYes186
70B:B:D258 B:B:F222 17.22134.78YesYes178
71B:B:D258 B:B:R22 14.469311.91YesNo076
72B:B:I18 B:B:R22 10.33815.01NoNo076
73B:B:D247 B:B:S227 26.38975.89YesYes196
74B:B:D247 B:B:H225 17.322610.08YesYes199
75B:B:H225 B:B:R251 17.050221.44YesYes198
76B:B:F253 B:B:R251 24.34533.21YesYes168
77B:B:C271 B:B:D290 24.27893.11NoYes056
78B:B:C271 B:B:D291 24.00586.22NoNo058
79B:B:D291 B:B:N293 23.73275.39NoNo085
80B:B:N293 B:B:N295 23.45954.09NoYes056
81B:B:N295 B:B:W297 19.33323.39YesYes1668
82B:B:W297 B:B:Y264 18.79174.82YesYes085
83B:B:R68 B:B:Y85 60.452711.32YesYes354
84B:B:M325 G:G:P49 12.74936.71YesNo057
85G:G:D48 G:G:P49 12.12973.22YesNo097
86B:B:S279 G:G:D48 11.198310.31NoYes099
87B:B:S279 G:G:L50 11.04284.5NoNo099
88B:B:V327 G:G:L50 10.88734.47NoNo069
89B:B:L286 B:B:V327 10.5764.47NoNo076
90B:B:Y85 G:G:F61 59.182210.32YesYes348
91B:B:M325 G:G:F61 12.02683.73YesYes058
92B:B:L51 B:B:W82 71.34114.81NoYes099
93B:B:I338 G:G:F61 71.01933.77NoYes058
94B:B:I338 B:B:L51 71.12634.28NoNo059
95B:B:F241 B:B:F253 20.635413.93YesYes166
96B:B:F234 B:B:F241 11.02046.43YesYes056
97B:B:L210 B:B:V200 13.77774.47NoNo056
98B:B:L210 B:B:R219 11.02263.64NoNo055
99R:R:M215 R:R:Y219 53.29613.59YesYes089
100R:R:F282 R:R:M215 46.71244.98YesYes798
101R:R:F208 R:R:F282 12.14947.5YesYes089
102R:R:F208 R:R:F290 10.369418.22YesYes087
103L:L:?1 R:R:F290 20.51235.9YesYes707
104R:R:W313 R:R:Y316 10.226312.54YesYes056
105R:R:F282 R:R:W286 34.55996.01YesYes798
106R:R:F290 R:R:W286 10.39258.02YesYes778
107R:R:V117 R:R:W286 10.39119.81NoYes068
108L:L:?1 R:R:V117 10.27267.21YesNo006
109R:R:F289 R:R:W286 13.42916.01YesYes768
110L:L:?1 R:R:F289 10.300810.81YesYes706
111R:R:D130 R:R:Y141 16.111611.49YesYes1487
112R:R:D130 R:R:F71 15.89653.58YesYes088
113R:R:F71 R:R:I154 15.43185.02YesNo088
114R:R:I154 R:R:S74 15.31866.19NoNo089
115R:R:S74 R:R:W158 15.09546.18NoYes099
116R:R:L115 R:R:W158 14.64613.42NoYes059
117R:R:L115 R:R:S165 14.44026.01NoNo057
118R:R:S165 R:R:V114 10.33173.23NoNo075
119L:L:?1 R:R:V114 10.22519.62YesNo005
120L:L:?1 R:R:D113 18.242712.04YesNo707
121R:R:D113 R:R:V86 17.656211.69NoNo077
122R:R:V86 R:R:W109 16.43984.9NoYes075
123L:L:?1 R:R:F193 14.627310.81YesYes004
124R:R:F193 R:R:Y174 12.19224.13YesYes045
125R:R:Y174 R:R:Y185 12.3948.94YesNo051
126R:R:A181 R:R:Y185 10.93664NoNo041
127B:B:L69 B:B:R68 59.97014.86YesYes355
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


2D representation of the interactions of this orthosteric/allosteric ligand.


Links and nodes colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:D113 R:R:V86 11.69 7 No No 7 7 1 2
R:R:D113 R:R:Y316 12.64 7 No Yes 7 6 1 1
L:L:?1 R:R:D113 12.04 7 Yes No 0 7 0 1
R:R:S165 R:R:V114 3.23 0 No No 7 5 2 1
L:L:?1 R:R:V114 9.62 7 Yes No 0 5 0 1
R:R:V117 R:R:W286 9.81 0 No Yes 6 8 1 2
L:L:?1 R:R:V117 7.21 7 Yes No 0 6 0 1
R:R:S207 R:R:T118 7.99 0 No No 5 6 1 2
R:R:F193 R:R:Y174 4.13 0 Yes Yes 4 5 1 2
R:R:Y174 R:R:Y199 3.97 8 Yes Yes 5 6 2 2
R:R:F193 R:R:T195 10.38 0 Yes No 4 3 1 2
L:L:?1 R:R:F193 10.81 7 Yes Yes 0 4 0 1
R:R:T195 R:R:Y199 6.24 0 No Yes 3 6 2 2
R:R:S203 R:R:Y199 8.9 0 No Yes 5 6 1 2
L:L:?1 R:R:S203 7.27 7 Yes No 0 5 0 1
L:L:?1 R:R:S207 3.63 7 Yes No 0 5 0 1
R:R:F208 R:R:F290 18.22 0 Yes Yes 8 7 2 1
R:R:F289 R:R:W286 6.01 7 Yes Yes 6 8 1 2
R:R:F290 R:R:W286 8.02 7 Yes Yes 7 8 1 2
R:R:F289 R:R:F290 5.36 7 Yes Yes 6 7 1 1
R:R:F289 R:R:Y308 10.32 7 Yes No 6 5 1 2
R:R:F289 R:R:L311 3.65 7 Yes No 6 5 1 2
R:R:F289 R:R:N312 13.29 7 Yes No 6 5 1 1
L:L:?1 R:R:F289 10.81 7 Yes Yes 0 6 0 1
L:L:?1 R:R:F290 5.9 7 Yes Yes 0 7 0 1
R:R:N312 R:R:Y316 17.44 7 No Yes 5 6 1 1
L:L:?1 R:R:N312 11.08 7 Yes No 0 5 0 1
R:R:W313 R:R:Y316 12.54 0 Yes Yes 5 6 2 1
L:L:?1 R:R:Y316 5.67 7 Yes Yes 0 6 0 1
R:R:F193 R:R:T110 2.59 0 Yes No 4 4 1 2
R:R:S203 R:R:T164 1.6 0 No No 5 5 1 2

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

ShowSimilarityNetwork TypeNameLigandDescription
100.00Single7DHISalbutamol7DHI-β2-Salbutamol-Gs/&β;1/&γ;2
100.00Single8GE1Epinephrine8GE1-β2-Epinephrine-Gs/&β;1/&γ;2
100.00Single8GE4Epinephrine8GE4-β2-Epinephrine-Gs/&β;1/&γ;2
100.00Single8GE6Epinephrine8GE6-β2-Epinephrine-Gs/&β;1/&γ;2
100.00Single8GE7Epinephrine8GE7-β2-Epinephrine-Gs/&β;1/&γ;2
100.00Single8GE8Epinephrine8GE8-β2-Epinephrine-Gs/&β;1/&γ;2
100.00Single8GFVEpinephrine8GFV-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
100.00Single8GG4Epinephrine8GG4-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
100.00Single8GGIEpinephrine8GGI-β2-Epinephrine
100.00Single8UNQEpinephrine8UNQ-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
90.91Single6H7MSalbutamol6H7M-β1-Salbutamol
90.91Single7BTSL-Epinephrine7BTS-β1-L-Epinephrine
90.91Single7BU6L-Norepinephrine7BU6-β1-L-Norepinephrine
90.91Single8GE3Epinephrine8GE3-β2-Epinephrine-Gs/&β;1/&γ;2
90.91Single8GEBEpinephrine8GEB-β2-Epinephrine-Gs/&β;1/&γ;2
90.91Single8GEEEpinephrine8GEE-β2-Epinephrine-Gs/&β;1/&γ;2
90.91Single8GFWEpinephrine8GFW-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
90.91Single8GFXEpinephrine8GFX-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
90.91Single8GFYEpinephrine8GFY-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
90.91Single8GFZEpinephrine8GFZ-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
90.91Single8GG0Epinephrine8GG0-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
90.91Single8GG1Epinephrine8GG1-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
90.91Single8GG2Epinephrine8GG2-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
90.91Single8GG6Epinephrine8GG6-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
90.91Single8GGJEpinephrine8GGJ-β2-Epinephrine
90.91Single8GGNEpinephrine8GGN-β2-Epinephrine
90.91Single8GGOEpinephrine8GGO-β2-Epinephrine
90.91Single8GGUEpinephrine8GGU-β2-Epinephrine
90.91Single8UNNEpinephrine8UNN-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
90.91Single8UNPEpinephrine8UNP-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
90.91Consensusadrenergic_onOrthosteric Ligandbeta_on alpha_on
90.91Consensusamine_onOrthosteric Ligandadrenergic_on histamine_on muscarinic_on tar_on 5ht_on dopamine_on
90.91Consensusd5_onOrthosteric Ligand8IRV-D5-Rotigotine-chim(NtGi1-Gs)/&β;1/&γ;2
90.91Consensusdopamine_onOrthosteric Ligandd3_on d2_on d5_on d1_on
90.00Single7YMHNorepinephrine7YMH-Alpha1A-Norepinephrine-chim(Gs-CtGq)/&β;1/&γ;2
90.00Single8GEAEpinephrine8GEA-β2-Epinephrine-Gs/&β;1/&γ;2
90.00Single8GECEpinephrine8GEC-β2-Epinephrine-Gs/&β;1/&γ;2
90.00Single8GEFEpinephrine8GEF-β2-Epinephrine-Gs/&β;1/&γ;2
90.00Single8GG7Epinephrine8GG7-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
90.00Single8GGAEpinephrine8GGA-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
90.00Single8GGVEpinephrine8GGV-β2-Epinephrine
90.00Single8GGWEpinephrine8GGW-β2-Epinephrine
90.00Single8GGXEpinephrine8GGX-β2-Epinephrine
90.00Single8GH0Epinephrine8GH0-β2-Epinephrine
90.00Single8UNOEpinephrine8UNO-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
83.33Single2RH1(S)-Carazolol2RH1-β2-(S)-Carazolol
83.33Single2Y03Isoprenaline2Y03-β1-Isoprenaline
83.33Single6KUWPubChem 572132346KUW-α2c-PubChem 57213234
83.33Single6PS3(S)-Carvedilol6PS3-β2-(S)-Carvedilol
83.33Single7BVQ(S)-Carazolol7BVQ-β1-(S)-Carazolol
83.33Single7S0FIsoprenaline7S0F-β1-Isoprenaline-Gi1/&β;1/&γ;2
83.33Single7XKAEpinephrine7XKA-β2-Epinephrine
83.33Single8UNYEpinephrine8UNY-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
83.33Consensusalpha2c_offOrthosteric Ligand6KUW-α2c-PubChem 57213234
83.33Consensusamine_offOrthosteric Ligandadrenergic_off histamine_off muscarinic_off 5ht_off dopamine_off
83.33Consensusbeta2_offOrthosteric Ligand6PS2-β2-(S)-Alprenolol 6PS3-β2-(S)-Carvedilol 6PS5-β2-(S)-Propranolol 6PS6-β2-Timolol 2RH1-β2-(S)-Carazolol 6PS4-β2-ICI 118-551 3NY9-β2-PubChem 913103
83.33Consensusbeta2_onOrthosteric Ligand3SN6-β2-BI167107-Gs/&β;1/&γ;2 7DHR-β2-Isoprenaline-Gs/&β;1/&γ;2 7BZ2-β2-Arformoterol-Gs/&β;1/&γ;2 7DHI-β2-Salbutamol-Gs/&β;1/&γ;2
83.33Consensusbeta_offOrthosteric Ligandbeta1_off beta2_off
83.33Consensusbeta_onOrthosteric Ligandbeta1_on beta2_on beta3_on
83.33Consensusd2_onOrthosteric Ligand7JVR-D2-Bromoergocryptine-Gi1/&β;1/&γ;2 8IRS-D2-Rotigotine-Gi1/&β;1/&γ;2
83.33Consensusgi_adrenergicOrthosteric Ligand7S0F-β1-Isoprenaline-Gi1/&β;1/&γ;2 6K42-α2b-Dexmedetomidine-Gi1/&β;1/&γ;2
83.33Consensusgs_adrenergicOrthosteric Ligand3SN6-β2-BI167107-Gs/&β;1/&γ;2 7DHR-β2-Isoprenaline-Gs/&β;1/&γ;2 7DHI-β2-Salbutamol-Gs/&β;1/&γ;2 7XJH-β3-Isoproterenol-Gs/&β;1/&γ;2 7DH5-β3-Mirabegron-Gs/&β;1/&γ;2 7XJI-β3-Solabegron-Gs/&β;1/&γ;2 8THK-Alpha1A-A61603-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8THL-Alpha1A-Epinephrine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 7JJO-β1-Isoprenaline-Gs/&β;1/&γ;2 8DCR-β1-Dobutamine-Gs/&β;1/&γ;2 7BZ2-β2-Arformoterol-Gs/&β;1/&γ;2
83.33Consensusta1_onOrthosteric Ligand8W87-TA1-METH-chim(NtGi1L-Gs)/&β;1/&γ;2 8W89-TA1-PEA-chim(NtGi1L-Gs)/&β;1/&γ;2 8JLP-TA1-Ralmitaront-Gs/&β;1/&γ;2 8W8A-TA1-RO5256390-chim(NtGi1L-Gs)/&β;1/&γ;2 8W88-TA1-SEP-363856-Gs/&β;1/&γ;2 8JLN-TA1-T1AM-Gs/&β;1/&γ;2 8JLO-TA1-Ulotaront-Gs/&β;1/&γ;2 8JLR-TA1-A77636-chim(NtGi1-Gs)/&β;1/&γ;2 8JSO-TA1-AMPH-chim(NtGi1-Gs)/&β;1/&γ;2 8JLQ-TA1-Fenoldopam-Gs/&β;1/&γ;2 8WCA-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/&β;1/&γ;2
81.82Single4LDOL-Epinephrine4LDO-β2-L-Epinephrine
81.82Single6PS4ICI 118-5516PS4-β2-ICI 118-551
81.82Single6PS5(S)-Propranolol6PS5-β2-(S)-Propranolol
81.82Single7CMUPramipexole7CMU-D3-Pramipexole-Gi1/&β;1/&γ;2
81.82Single7RANPubChem 1645758477RAN-5-HT2A-PubChem 164575847-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
81.82Single8GDZEpinephrine8GDZ-β2-Epinephrine-Gs/&β;1/&γ;2
81.82Single8GEGEpinephrine8GEG-β2-Epinephrine-Gs/&β;1/&γ;2
81.82Single8GG3Epinephrine8GG3-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
81.82Single8GG5Epinephrine8GG5-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
81.82Single8GG8Epinephrine8GG8-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
81.82Single8GGKEpinephrine8GGK-β2-Epinephrine
81.82Single8GGMEpinephrine8GGM-β2-Epinephrine
81.82Single8GGPEpinephrine8GGP-β2-Epinephrine
81.82Single8GGQEpinephrine8GGQ-β2-Epinephrine
81.82Single8GGTEpinephrine8GGT-β2-Epinephrine
81.82Single8JLNT1AM8JLN-TA1-T1AM-Gs/&β;1/&γ;2
81.82Single8THKA616038THK-Alpha1A-A61603-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
81.82Single8UNREpinephrine8UNR-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
81.82Single8UNSEpinephrine8UNS-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
81.82Single8UNZEpinephrine8UNZ-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
81.82Consensusd3_onOrthosteric Ligand8IRT-D3-Rotigotine-Gi1/&β;1/&γ;2 7CMV-D3-PD128907-Gi1/&β;1/&γ;2 7CMU-D3-Pramipexole-Gi1/&β;1/&γ;2
80.00Single8GEIEpinephrine8GEI-β2-Epinephrine-Gs/&β;1/&γ;2
80.00Single8GGSEpinephrine8GGS-β2-Epinephrine
80.00Single8GGYEpinephrine8GGY-β2-Epinephrine
80.00Single8UNVEpinephrine8UNV-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
80.00Single8UNXEpinephrine8UNX-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
76.92Single4LDLHydroxybenzylisoproterenol4LDL-β2-Hydroxybenzylisoproterenol
76.92Single5D5A(S)-Carazolol5D5A-β2-(S)-Carazolol
76.92Single5D5B(S)-Carazolol5D5B-β2-(S)-Carazolol
76.92Single6H7JIsoprenaline6H7J-β1-Isoprenaline
76.92Single6N48BI1671076N48-β2-BI167107-PubChem 138454256
76.92Single7JJOIsoprenaline7JJO-β1-Isoprenaline-Gs/&β;1/&γ;2
76.92Single7W6PW967W6P-α2a-W96-Go/&β;1/&γ;2
76.92Single7W7EW587W7E-α2a-W58-Go/&β;1/&γ;2
76.92Single8IRRRotigotine8IRR-D1-Rotigotine-Gs/&β;1/&γ;2
76.92Consensusbeta1_offOrthosteric Ligand2VT4-β1-Cyanopindolol 2YCZ-β1-Iodocyanopindolol
76.92Consensusgi_amineOrthosteric Ligandgi_5ht gi_adrenergic gi_dopamine gi_muscarinic gi_histamine
76.92Consensusgi_dopamineOrthosteric Ligand8IRT-D3-Rotigotine-Gi1/&β;1/&γ;2 7JVR-D2-Bromoergocryptine-Gi1/&β;1/&γ;2 8IRS-D2-Rotigotine-Gi1/&β;1/&γ;2 7CMV-D3-PD128907-Gi1/&β;1/&γ;2 7CMU-D3-Pramipexole-Gi1/&β;1/&γ;2
76.92Consensusgs_dopamineOrthosteric Ligand7F0T-D1-Dopamine-Gs/&β;1/&γ;2 7CKX-D1-A77636-Gs/&β;1/&γ;2 7JVQ-D1-Apomorphine-Gs/&β;1/&γ;2 7CKY-D1-PW0464-Gs/&β;1/&γ;2 8IRV-D5-Rotigotine-chim(NtGi1-Gs)/&β;1/&γ;2 7JV5-D1-SKF81297-Gs/&β;1/&γ;2 7JVP-D1-SKF83959-Gs/&β;1/&γ;2 7X2D-D1-Tavapadon-Gs/&β;1/&γ;2 7JOZ-D1-VFP-Gs/&β;1/&γ;2
75.00Single2VT4Cyanopindolol2VT4-β1-Cyanopindolol
75.00Single2Y04Salbutamol2Y04-β1-Salbutamol
75.00Single2YCYCyanopindolol2YCY-β1-Cyanopindolol
75.00Single3NY8ICI 118-5513NY8-β2-ICI 118-551
75.00Single3NYA(S)-Alprenolol3NYA-β2-(S)-Alprenolol
75.00Single3ZPQ4-(piperazin-1- yl)-1H-indole3ZPQ-β1-4-(piperazin-1- yl)-1H-indole-Na
75.00Single4GBR(S)-Carazolol4GBR-β2-(S)-Carazolol
75.00Single4QKXPubChem 762106284QKX-β2-PubChem 76210628
75.00Single5JQH(S)-Carazolol5JQH-β2-(S)-Carazolol
75.00Single6PRZ(S)-Alprenolol6PRZ-β2-(S)-Alprenolol
75.00Single6PS0(S)-Carazolol6PS0-β2-(S)-Carazolol
75.00Single6PS1Timolol6PS1-β2-Timolol
75.00Single6PS2(S)-Alprenolol6PS2-β2-(S)-Alprenolol
75.00Single7E32Serotonin7E32-5-HT1D-Serotonin-Gi1/&β;1/&γ;2
75.00Single7JVQApomorphine7JVQ-D1-Apomorphine-Gs/&β;1/&γ;2
75.00Single7S0GIsoprenaline7S0G-β1-Isoprenaline-chim(Gi1-CtGs)/&β;1/&γ;2
75.00Single7WC7Lisuride7WC7-5-HT2A-Lisuride
75.00Single7XJHIsoproterenol7XJH-β3-Isoproterenol-Gs/&β;1/&γ;2
75.00Single8GEHEpinephrine8GEH-β2-Epinephrine-Gs/&β;1/&γ;2
75.00Single8GGBEpinephrine8GGB-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
75.00Single8IRTRotigotine8IRT-D3-Rotigotine-Gi1/&β;1/&γ;2
75.00Single8JJOAlprenolol8JJO-β2-Alprenolol
75.00Single8JLJT1AM8JLJ-TA1-T1AM-chim(NtGi1-Gs)/&β;1/&γ;2
75.00Single8UNMEpinephrine8UNM-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
75.00Single8UO4Epinephrine8UO4-β2-Epinephrine-GTP; Mg-Gs/&β;1/&γ;2
75.00Single8W87METH8W87-TA1-METH-chim(NtGi1L-Gs)/&β;1/&γ;2
75.00Single8W8ARO52563908W8A-TA1-RO5256390-chim(NtGi1L-Gs)/&β;1/&γ;2
75.00Single8WC7ZH86678WC7-TA1-ZH8667-chim(NtGi1-Gs)/&β;1/&γ;2
75.00Consensus5ht1d_onOrthosteric Ligand7E32-5-HT1D-Serotonin-Gi1/&β;1/&γ;2
75.00Consensusalpha2_onOrthosteric Ligandalpha2a_on alpha2b_on
75.00Consensusalpha_onOrthosteric Ligandalpha1_on alpha2_on
75.00Consensusgi_5htOrthosteric Ligand7E2Y-5-HT1A-Serotonin-Gi1/&β;1/&γ;2 8JSP-5-HT1A-Ulotaront-Gi1/&β;1/&γ;2 7E32-5-HT1D-Serotonin-Gi1/&β;1/&γ;2 7E33-5-HT1E-BRL-54443-Gi1/&β;1/&γ;2 7EXD-5-HT1F-Lasmiditan-Gi1/&β;1/&γ;2 7XTA-5-HT4-Serotonin-Gi1/&β;1/&γ;2 7X5H-5-HT5A-5-CT-Gi1/&β;1/&γ;2 7E2Z-5-HT1A-Aripiprazole-Gi1/&β;1/&γ;2 8W8B-5-HT1A-SEP-363856-Gi1/&β;1/&γ;2
75.00Consensustar_onOrthosteric Ligandta1_on
72.73Single6KUXRS-799486KUX-α2a-RS-79948
72.73Single6KUYPubChem 1457046436KUY-α2a-PubChem 145704643
72.73Single6OBA(S)-Alprenolol6OBA-β2-(S)-Alprenolol-GTPL11074
72.73Single7DHRIsoprenaline7DHR-β2-Isoprenaline-Gs/&β;1/&γ;2
72.73Single7F24Dopamine7F24-D1-Dopamine-GDP-Gs/&β;1/&γ;2
72.73Single7X5H5-CT7X5H-5-HT5A-5-CT-Gi1/&β;1/&γ;2
72.73Single8GEDEpinephrine8GED-β2-Epinephrine-Gs/&β;1/&γ;2
72.73Single8GG9Epinephrine8GG9-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
72.73Single8UNLEpinephrine8UNL-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
72.73Single8UNTEpinephrine8UNT-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
72.73Single8UNUEpinephrine8UNU-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
72.73Single8UNWEpinephrine8UNW-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
72.73Single8UO0Epinephrine8UO0-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
72.73Single8UO1Epinephrine8UO1-β2-Epinephrine-GTP; Mg-Gs/&β;1/&γ;2
72.73Single8UO3Epinephrine8UO3-β2-Epinephrine-GTP; Mg-Gs/&β;1/&γ;2
72.73Single8WC4ZH86518WC4-TA1-ZH8651-chim(NtGi1-Gs)/&β;1/&γ;2
72.73Single8WCA2-Phenylethylamine8WCA-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/&β;1/&γ;2
72.73Consensus5ht2_onOrthosteric Ligand5ht2a_on 5ht2c_on
72.73Consensus5ht_onOrthosteric Ligand5ht1_on 5ht2_on 5ht4_on 5ht5_on 5ht6_on 5ht7_on
72.73Consensusalpha1_onOrthosteric Ligandalpha1a_on
72.73Consensusalpha1a_onOrthosteric Ligand7YMH-Alpha1A-Norepinephrine-chim(Gs-CtGq)/&β;1/&γ;2 7YM8-Alpha1A-Oxymetazoline-chim(Gs-CtGq)/&β;1/&γ;2 8THK-Alpha1A-A61603-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8THL-Alpha1A-Epinephrine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
72.73Consensusalpha2a_offOrthosteric Ligand6KUX-α2a-RS-79948
72.73Consensusbeta2_off_alloOrthosteric Ligand6OBA-β2-(S)-Alprenolol-GTPL11074
71.43Single3D4STimolol Maleate3D4S-β2-Timolol Maleate
71.43Single4AMIBucindolol4AMI-β1-Bucindolol
71.43Single4LDEBI1671074LDE-β2-BI167107
71.43Single6DRYMethylergonovine6DRY-5-HT2B-Methylergonovine
71.43Single6H7N(S)-Xamoterol6H7N-β1-(S)-Xamoterol
71.43Single6H7OCyanopindolol6H7O-β1-Cyanopindolol
71.43Single6TKOArformoterol6TKO-β1-Arformoterol-Arrestin2
71.43Single8IRVRotigotine8IRV-D5-Rotigotine-chim(NtGi1-Gs)/&β;1/&γ;2
71.43Single8JJ8Formoterol8JJ8-β2-Formoterol
71.43Consensusbeta1_onOrthosteric Ligand7JJO-β1-Isoprenaline-Gs/&β;1/&γ;2 8DCR-β1-Dobutamine-Gs/&β;1/&γ;2
71.43Consensusgs_amineOrthosteric Ligandgs_5ht gs_adrenergic gs_dopamine gs_histamine gs_muscarinic gs_tar
70.00Single8GGREpinephrine8GGR-β2-Epinephrine
70.00Single8GGZEpinephrine8GGZ-β2-Epinephrine
70.00Single8WC9ZH86518WC9-TA1-ZH8651-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
69.23Single2YCW(S)-Carazolol2YCW-β1-(S)-Carazolol
69.23Single5D6L(S)-Carazolol5D6L-β2-(S)-Carazolol
69.23Single5WIUNemonapride5WIU-D4-Nemonapride
69.23Single5WIVNemonapride5WIV-D4-Nemonapride-Na
69.23Single5X7D(S)-Carazolol5X7D-β2-(S)-Carazolol-PubChem 129318963
69.23Single6E67BI1671076E67-β2-BI167107-Gs (fused)
69.23Single7BZ2Arformoterol7BZ2-β2-Arformoterol-Gs/&β;1/&γ;2
69.23Single7WC6LSD7WC6-5-HT2A-LSD
69.23Consensus5ht1_onOrthosteric Ligand5ht1a_on 5ht1d_on 5ht1e_on 5ht1f_on 5ht1b_on
69.23Consensusadrenergic_offOrthosteric Ligandbeta_off alpha_off
69.23Consensusbeta3_onOrthosteric Ligand7DH5-β3-Mirabegron-Gs/&β;1/&γ;2 7XJH-β3-Isoproterenol-Gs/&β;1/&γ;2
69.23Consensusd1_onOrthosteric Ligand7F0T-D1-Dopamine-Gs/&β;1/&γ;2 7CKY-D1-PW0464-Gs/&β;1/&γ;2 8IRR-D1-Rotigotine-Gs/&β;1/&γ;2 7JV5-D1-SKF81297-Gs/&β;1/&γ;2 7JVP-D1-SKF83959-Gs/&β;1/&γ;2 7X2D-D1-Tavapadon-Gs/&β;1/&γ;2 7JOZ-D1-VFP-Gs/&β;1/&γ;2 7CKX-D1-A77636-Gs/&β;1/&γ;2 7JVQ-D1-Apomorphine-Gs/&β;1/&γ;2
69.23Consensusd4_offOrthosteric Ligand5WIU-D4-Nemonapride
69.23Consensusd4_off_alloOrthosteric Ligand5WIV-D4-Nemonapride-Na
66.67Single2YCZIodocyanopindolol2YCZ-β1-Iodocyanopindolol
66.67Single4BVNCyanopindolol4BVN-β1-Cyanopindolol-Na
66.67Single6A94Zotepine6A94-5-HT2A-Zotepine
66.67Single6H7LDobutamine6H7L-β1-Dobutamine
66.67Single6IBLArformoterol6IBL-β1-Arformoterol
66.67Single6K41Dexmedetomidine6K41-α2b-Dexmedetomidine-Go/&β;1/&γ;2
66.67Single6WH4Methiothepin6WH4-5-HT2A-Methiothepin
66.67Single7CKZDopamine7CKZ-D1-Dopamine-Mevidalen-Gs/&β;1/&γ;2
66.67Single7E33BRL-544437E33-5-HT1E-BRL-54443-Gi1/&β;1/&γ;2
66.67Single7JVRBromoergocryptine7JVR-D2-Bromoergocryptine-Gi1/&β;1/&γ;2
66.67Single7UM7Methylergometrine7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/&β;1/&γ;2
66.67Single8GGLEpinephrine8GGL-β2-Epinephrine
66.67Single8JLKUlotaront8JLK-TA1-Ulotaront-chim(NtGi1-Gs)/&β;1/&γ;2
66.67Single8JSPUlotaront8JSP-5-HT1A-Ulotaront-Gi1/&β;1/&γ;2
66.67Single8THLEpinephrine8THL-Alpha1A-Epinephrine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
66.67Single8UHBRO52563908UHB-TA1-RO5256390-Gs/&β;1/&γ;2
66.67Single8UO2Epinephrine8UO2-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
66.67Single8W88SEP-3638568W88-TA1-SEP-363856-Gs/&β;1/&γ;2
66.67Consensus5ht1e_onOrthosteric Ligand7E33-5-HT1E-BRL-54443-Gi1/&β;1/&γ;2
66.67Consensus5ht2a_onOrthosteric Ligand7RAN-5-HT2A-PubChem 164575847-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 6WHA-5-HT2A-DB13948-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
66.67Consensusalpha2b_onOrthosteric Ligand6K41-α2b-Dexmedetomidine-Go/&β;1/&γ;2
66.67Consensusbeta1_off_alloOrthosteric Ligand4BVN-β1-Cyanopindolol-Na
66.67Consensusd1_on_alloOrthosteric Ligand7LJC-D1-PubChem 86764103-Mevidalen-Gs/&β;1/&γ;2 7CKZ-D1-Dopamine-Mevidalen-Gs/&β;1/&γ;2
66.67Consensusgs_tarOrthosteric Ligand8W88-TA1-SEP-363856-Gs/&β;1/&γ;2 8JLN-TA1-T1AM-Gs/&β;1/&γ;2 8JLO-TA1-Ulotaront-Gs/&β;1/&γ;2 8JLQ-TA1-Fenoldopam-Gs/&β;1/&γ;2 8JLP-TA1-Ralmitaront-Gs/&β;1/&γ;2 8WCA-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/&β;1/&γ;2 8WCB-TA1-Cyclohexylammonium ion-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8WC8-TA1-ZH8651-chim(NtGi1-Gs)/&β;1/&γ;2
64.29Single2YDVNECA2YDV-A2A-NECA
64.29Single3P0GBI1671073P0G-β2-BI167107
64.29Single3SN6BI1671073SN6-β2-BI167107-Gs/&β;1/&γ;2
64.29Single4U15Tiotropium4U15-M3-Tiotropium
64.29Single4UHRCGS216804UHR-A2A-CGS21680
64.29Single5A8E7-Methylcyanopindolol5A8E-β1-7-Methylcyanopindolol-Na
64.29Single5G53NECA5G53-A2A-NECA-Gs
64.29Single5ZKBAF-DX 3845ZKB-M2-AF-DX 384
64.29Single6OL9Tiotropium6OL9-M5-Tiotropium
64.29Single6WGTLSD6WGT-5-HT2A-LSD
64.29Single7E2ZAripiprazole7E2Z-5-HT1A-Aripiprazole-Gi1/&β;1/&γ;2
64.29Single7JVPSKF839597JVP-D1-SKF83959-Gs/&β;1/&γ;2
64.29Single8DCSCyanopindolol8DCS-β1-Cyanopindolol-Gs/&β;1/&γ;2
64.29Single8IRURotigotine8IRU-D4-Rotigotine-chim(NtGi1-Gs-CtGi1)/&β;1/&γ;2
64.29Single8JT6(R)-IHCH-71798JT6-5-HT1A-(R)-IHCH-7179-Gi1/&β;1/&γ;2
64.29Consensus5ht5_offOrthosteric Ligand5ht5a_off
64.29Consensus5ht_offOrthosteric Ligand5ht2_off 5ht5_off 5ht1_off
64.29Consensusdopamine_offOrthosteric Ligandd3_off d2_off d4_off
64.29Consensusgo_adrenergicOrthosteric Ligand7EJ0-α2a-L-Norepinephrine-Go/&β;1/&γ;2 7EJK-α2a-Oxymetazoline-Go/&β;1/&γ;2 7W7E-α2a-W58-Go/&β;1/&γ;2 7W6P-α2a-W96-Go/&β;1/&γ;2 6K41-α2b-Dexmedetomidine-Go/&β;1/&γ;2 7EJ8-α2a-Brimonidine-Go/&β;1/&γ;2 7EJA-α2a-Dexmedetomidine-Go/&β;1/&γ;2
64.29Consensush1_offOrthosteric Ligand3RZE-H1-Cidoxepin 8X5Y-H1-Astemizole 8X63-H1-Mepyramine 8X64-H1-Desloratadine
64.29Consensushistamine_offOrthosteric Ligandh1_off
64.29Consensusm5_offOrthosteric Ligand6OL9-M5-Tiotropium
64.29Consensusmuscarinic_offOrthosteric Ligandm2_off m3_off m4_off m5_off m1_off
63.64Single3PBLEticlopride3PBL-D3-Eticlopride
63.64Single7DFLHistamine7DFL-H1-Histamine-chim(NtGi1L-Gq)/&β;1/&γ;2
63.64Single7E2YSerotonin7E2Y-5-HT1A-Serotonin-Gi1/&β;1/&γ;2
63.64Single7EJKOxymetazoline7EJK-α2a-Oxymetazoline-Go/&β;1/&γ;2
63.64Single7XTBSerotonin7XTB-5-HT6-Serotonin-Gs/&β;1/&γ;2
63.64Single7YS6Serotonin7YS6-5-HT6-Serotonin-chim(NtGi1-Gs)/&β;1/&γ;2
63.64Single8DPFLorcaserin8DPF-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
63.64Single8GGCEpinephrine8GGC-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
63.64Single8GGEEpinephrine8GGE-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
63.64Single8JLOUlotaront8JLO-TA1-Ulotaront-Gs/&β;1/&γ;2
63.64Single8W8BSEP-3638568W8B-5-HT1A-SEP-363856-Gi1/&β;1/&γ;2
63.64Single8WC3SEP-3638568WC3-TA1-SEP-363856-chim(NtGi1-Gs)/&β;1/&γ;2
63.64Consensus5ht4_onOrthosteric Ligand7XT8-5-HT4-Serotonin-Gs/&β;1/&γ;2
63.64Consensusd3_offOrthosteric Ligand3PBL-D3-Eticlopride
63.64Consensusgq_histamineOrthosteric Ligand7DFL-H1-Histamine-chim(NtGi1L-Gq)/&β;1/&γ;2
63.64Consensush1_onOrthosteric Ligand7DFL-H1-Histamine-chim(NtGi1L-Gq)/&β;1/&γ;2
62.50Single3NY9PubChem 9131033NY9-β2-PubChem 913103
62.50Single8JLRA776368JLR-TA1-A77636-chim(NtGi1-Gs)/&β;1/&γ;2
61.54Single2Y01Dobutamine2Y01-β1-Dobutamine
61.54Single2Y02Carmoterol2Y02-β1-Carmoterol
61.54Single3ZPR4-methyl-2-(piperazin-1-yl)3ZPR-β1-4-methyl-2-(piperazin-1-yl)-Na
61.54Single4U16N-Methyl Scopolamine4U16-M3-N-Methyl Scopolamine
61.54Single5YC8N-Methyl Scopolamine5YC8-M2-N-Methyl Scopolamine
61.54Single5ZK8N-Methyl Scopolamine5ZK8-M2-N-Methyl Scopolamine
61.54Single5ZKCN-Methyl Scopolamine5ZKC-M2-N-Methyl Scopolamine
61.54Single6DRZMethysergide6DRZ-5-HT2B-Methysergide
61.54Single6K42Dexmedetomidine6K42-α2b-Dexmedetomidine-Gi1/&β;1/&γ;2
61.54Single7BU7BI1671077BU7-β1-BI167107
61.54Single7CRHSKF839597CRH-D1-SKF83959-Gs/&β;1/&γ;2
61.54Single7LJCPubChem 867641037LJC-D1-PubChem 86764103-Mevidalen-Gs/&β;1/&γ;2
61.54Single7UM55-CT7UM5-5-HT5A-5-CT-chim(NtGi1-Go)/&β;1/&γ;2
61.54Single7UM6Lisuride7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/&β;1/&γ;2
61.54Single7X2CFenoldopam7X2C-D1-Fenoldopam-Fenoldopam-Gs/&β;1/&γ;2
61.54Single7XTC5-CT7XTC-5-HT7-5-CT-Gs/&β;1/&γ;2
61.54Single8X64Desloratadine8X64-H1-Desloratadine
61.54Consensus5ht1a_onOrthosteric Ligand8JSP-5-HT1A-Ulotaront-Gi1/&β;1/&γ;2 7E2Z-5-HT1A-Aripiprazole-Gi1/&β;1/&γ;2 8W8B-5-HT1A-SEP-363856-Gi1/&β;1/&γ;2 7E2Y-5-HT1A-Serotonin-Gi1/&β;1/&γ;2
61.54Consensus5ht2_offOrthosteric Ligand5ht2a_off 5ht2b_off 5ht2c_off
61.54Consensus5ht7_onOrthosteric Ligand7XTC-5-HT7-5-CT-Gs/&β;1/&γ;2
61.54Consensusgo_muscarinicOrthosteric Ligand8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/&β;1/&γ;2 7T8X-M2-Acetylcholine-chim(NtGi1-Go)/&β;1/&γ;2
61.54Consensusgq_amineOrthosteric Ligandgq_muscarinic gq_histamine
61.54Consensushistamine_onOrthosteric Ligandh1_on h4_on
60.00Single2YCXCyanopindolol2YCX-β1-Cyanopindolol
60.00Single5CXVTiotropium5CXV-M1-Tiotropium
60.00Single5F8UCyanopindolol5F8U-β1-Cyanopindolol
60.00Single6MXTSalmeterol6MXT-β2-Salmeterol
60.00Single6VMSBromoergocryptine6VMS-D2-Bromoergocryptine-Gi1/&β;1/&γ;2
60.00Single7DH5Mirabegron7DH5-β3-Mirabegron-Gs/&β;1/&γ;2
60.00Single7YMJTamsulosin7YMJ-Alpha1A-Tamsulosin
60.00Single8DPHLorcaserin8DPH-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
60.00Single8IRSRotigotine8IRS-D2-Rotigotine-Gi1/&β;1/&γ;2
60.00Consensusd2_offOrthosteric Ligand6CM4-D2-Risperidone 6LUQ-D2-Haloperidol 7DFP-D2-Spiperone
60.00Consensusgo_5htOrthosteric Ligand6G79-5-HT1B-Donitriptan-Go/&β;1/&γ;2 7UM5-5-HT5A-5-CT-chim(NtGi1-Go)/&β;1/&γ;2 7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/&β;1/&γ;2 7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/&β;1/&γ;2
60.00Consensusm1_offOrthosteric Ligand5CXV-M1-Tiotropium
58.82Single4AMJ(S)-Carvedilol4AMJ-β1-(S)-Carvedilol
58.82Single4IARErgotamine4IAR-5-HT1B-Ergotamine
58.82Single8DCRDobutamine8DCR-β1-Dobutamine-Gs/&β;1/&γ;2
58.33Single7LD4Adenosine7LD4-A1-Adenosine-Gi2/&β;1/&γ;2
58.33Single7LJDDopamine7LJD-D1-Dopamine-Mevidalen-Gs/&β;1/&γ;1
58.33Single7SRSLSD7SRS-5-HT2B-LSD-Arrestin2
58.33Single7X2FDopamine7X2F-D1-Dopamine-Mevidalen-Gs/&β;1/&γ;2
58.33Single7XT8Serotonin7XT8-5-HT4-Serotonin-Gs/&β;1/&γ;2
58.33Single7YM8Oxymetazoline7YM8-Alpha1A-Oxymetazoline-chim(Gs-CtGq)/&β;1/&γ;2
58.33Single8IW4Spermidine8IW4-TAAR9-Spermidine-chim(NtGi1-Gs)/&β;1/&γ;2
58.33Single8IWESpermidine8IWE-TAAR9-Spermidine
58.33Consensus5ht2c_onOrthosteric Ligand8DPF-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8DPG-5-HT2C-Psilocin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
58.33Consensusa1_onOrthosteric Ligand7LD4-A1-Adenosine-Gi2/&β;1/&γ;2
58.33Consensusalpha2_offOrthosteric Ligandalpha2a_off alpha2c_off
58.33Consensusgi_nucleotideOrthosteric Ligand7LD4-A1-Adenosine-Gi2/&β;1/&γ;2
58.33Consensusgs_5htOrthosteric Ligand7XT8-5-HT4-Serotonin-Gs/&β;1/&γ;2 7XTB-5-HT6-Serotonin-Gs/&β;1/&γ;2 8JLZ-5-HT6-ST1936-Gs/&β;1/&γ;2 7XTC-5-HT7-5-CT-Gs/&β;1/&γ;2 6WHA-5-HT2A-DB13948-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 7RAN-5-HT2A-PubChem 164575847-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8DPF-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8DPG-5-HT2C-Psilocin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
57.14Single2Y00Dobutamine2Y00-β1-Dobutamine
57.14Single5C1MBU725C1M-μ-BU72
57.14Single5TVNLSD5TVN-5-HT2B-LSD
57.14Single6ME72-Phenylmelatonin6ME7-MT2-2-Phenylmelatonin
57.14Single6ME82-Phenylmelatonin6ME8-MT2-2-Phenylmelatonin
57.14Single6PS6Timolol6PS6-β2-Timolol
57.14Single7CKXA776367CKX-D1-A77636-Gs/&β;1/&γ;2
57.14Single8DZRGR89,6968DZR-κ-GR89,696-chim(NtGi2-Gt3)/&β;1/&γ;2
57.14Single8E9ZIperoxo8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
57.14Consensus5ht2b_offOrthosteric Ligand6DRZ-5-HT2B-Methysergide 6DRX-5-HT2B-Lisuride
57.14Consensusalpha2a_onOrthosteric Ligand7EJ0-α2a-L-Norepinephrine-Go/&β;1/&γ;2 7EJK-α2a-Oxymetazoline-Go/&β;1/&γ;2 7W7E-α2a-W58-Go/&β;1/&γ;2 7W6P-α2a-W96-Go/&β;1/&γ;2 7EJ8-α2a-Brimonidine-Go/&β;1/&γ;2 7EJA-α2a-Dexmedetomidine-Go/&β;1/&γ;2
57.14Consensusgo_amineOrthosteric Ligandgo_adrenergic go_muscarinic go_5ht
57.14Consensusgs_muscarinicOrthosteric Ligand8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
57.14Consensusm2_offOrthosteric Ligand5ZKB-M2-AF-DX 384 5ZKC-M2-N-Methyl Scopolamine 5ZK3-M2-Quinuclidinyl benzilate hydrobromide
57.14Consensusm3_onOrthosteric Ligand8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
56.25Single7SK8CCX6627SK8-ACKR3-CXCL12-CCX662
56.25Single7UM4AS26747237UM4-5-HT5A-AS2674723
56.25Single7XJISolabegron7XJI-β3-Solabegron-Gs/&β;1/&γ;2
56.25Single8E9X2-Deoxycytidine8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/&β;1/&γ;2
56.25Single8E9YPubChem 4466038E9Y-M3-PubChem 446603-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
56.25Single8FX5Xanomeline8FX5-M4-Xanomeline-Xanomeline-Gi1/&β;1/&γ;2
56.25Consensus5ht5a_offOrthosteric Ligand7UM4-5-HT5A-AS2674723
54.55Single6FUFAll-trans-retinal6FUF-Rhodopsin-All-trans-retinal-Go/&β;1/&γ;2
54.55Single8DPILorcaserin8DPI-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
54.55Single8POKHistamine8POK-H2-Histamine-Gs/&β;1/&γ;2
54.55Single8WC62-Phenylethylamine8WC6-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/&β;1/&γ;2
53.85Single4MQTIperoxo4MQT-M2-Iperoxo-LY2119620
53.85Single6ME32-Phenylmelatonin6ME3-MT1-2-Phenylmelatonin
53.85Single6TPGEMPA6TPG-OX2-EMPA
53.85Single6WJCAtropine6WJC-M1-Atropine-Muscarinic toxin 7
53.85Single7CKWFenoldopam7CKW-D1-Fenoldopam-Gs/&β;1/&γ;2
53.85Single7CMVPD1289077CMV-D3-PD128907-Gi1/&β;1/&γ;2
53.85Single7EJ8Brimonidine7EJ8-α2a-Brimonidine-Go/&β;1/&γ;2
53.85Single7F0TDopamine7F0T-D1-Dopamine-Gs/&β;1/&γ;2
53.85Single7F1ZDopamine7F1Z-D1-Dopamine-GDP-Gs/&β;1/&γ;2
53.85Single7JOZVFP7JOZ-D1-VFP-Gs/&β;1/&γ;2
53.85Single7T94Acetylcholine7T94-M2-Acetylcholine-PubChem 57664406-chim(NtGi1-Go)/&β;1/&γ;2
53.85Single7TRSAcetylcholine7TRS-M4-Acetylcholine-Gi1/&β;1/&γ;2
53.85Single8DPGPsilocin8DPG-5-HT2C-Psilocin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
53.85Single8JLQFenoldopam8JLQ-TA1-Fenoldopam-Gs/&β;1/&γ;2
53.85Consensus5ht5_onOrthosteric Ligand5ht5a_on
53.85Consensus5ht5a_onOrthosteric Ligand7UM5-5-HT5A-5-CT-chim(NtGi1-Go)/&β;1/&γ;2 7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/&β;1/&γ;2 7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/&β;1/&γ;2
53.85Consensusm1_off_alloOrthosteric Ligand6WJC-M1-Atropine-Muscarinic toxin 7
53.33Single3PDSHydroxybenzylisoproterenol3PDS-β2-Hydroxybenzylisoproterenol
53.33Single4RWADIPP-NH24RWA-δ-DIPP-NH2
53.33Single5V54Methiothepin5V54-5-HT1B-Methiothepin
53.33Single6J21Aprepitant6J21-NK1-Aprepitant
53.33Single6NI3BI1671076NI3-β2-BI167107-Gs/&β;1/&γ;2
53.33Single6TQ7SB-3348676TQ7-OX1-SB-334867
53.33Single7JV5SKF812977JV5-D1-SKF81297-Gs/&β;1/&γ;2
53.33Single7TRQIperoxo7TRQ-M4-Iperoxo-VU0467154-Gi1/&β;1/&γ;2
53.33Single7VGY2-Iodomelatonin7VGY-MT1-2-Iodomelatonin-Gi1/&β;1/&γ;2
53.33Single8E0GBU728E0G-μ-BU72
53.33Single8JLPRalmitaront8JLP-TA1-Ralmitaront-Gs/&β;1/&γ;2
53.33Consensus5ht1_offOrthosteric Ligand5ht1b_off
53.33Consensus5ht1b_offOrthosteric Ligand5V54-5-HT1B-Methiothepin
53.33Consensusa2_onOrthosteric Liganda2a_on a2b_on
53.33Consensusm3_offOrthosteric Ligand4U15-M3-Tiotropium 4U16-M3-N-Methyl Scopolamine 5ZHP-M3-PubChem 134828589
53.33Consensusnk1_offOrthosteric Ligand6J20-NK1-Aprepitant 6HLL-NK1-CP99994 6E59-NK1-L-760735
52.94Single4UG2CGS216804UG2-A2A-CGS21680
52.94Single8X5YAstemizole8X5Y-H1-Astemizole
50.00Single4DAJTiotropium4DAJ-M3-Tiotropium
50.00Single4EA3PubChem 102965614EA3-NOP-PubChem 10296561
50.00Single4EJ4Naltrindole4EJ4-δ-Naltrindole
50.00Single4MQSIperoxo4MQS-M2-Iperoxo
50.00Single4U14Tiotropium4U14-M3-Tiotropium
50.00Single5DSGTiotropium5DSG-M4-Tiotropium
50.00Single6CM4Risperidone6CM4-D2-Risperidone
50.00Single6ME62-Phenylmelatonin6ME6-MT2-2-Phenylmelatonin
50.00Single6PS82-Phenylmelatonin6PS8-MT1-2-Phenylmelatonin
50.00Single6WHADB139486WHA-5-HT2A-DB13948-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
50.00Single7EXDLasmiditan7EXD-5-HT1F-Lasmiditan-Gi1/&β;1/&γ;2
50.00Single7SQOTAK-9257SQO-OX2-TAK-925-Gi1/&β;1/&γ;2
50.00Single7SRQLSD7SRQ-5-HT2B-LSD
50.00Single7T2GMitragynine pseudoindoxyl7T2G-μ-Mitragynine pseudoindoxyl-Gi1/&β;1/&γ;2
50.00Single7TRPIperoxo7TRP-M4-Iperoxo-LY2033298-Gi1/&β;1/&γ;2
50.00Single7UL4Alvimopan7UL4-μ-Alvimopan
50.00Single7VGZRemalteon7VGZ-MT1-Remalteon-Gi1/&β;1/&γ;2
50.00Single7XT9Serotonin7XT9-5-HT4-Serotonin-Gs/&β;1/&γ;2
50.00Single7XTASerotonin7XTA-5-HT4-Serotonin-Gi1/&β;1/&γ;2
50.00Single7YACPaltusotine7YAC-SST2-Paltusotine-Gi1/&β;1/&γ;2
50.00Single7YITNalfurafine7YIT-κ-Nalfurafine
50.00Single8E9W2-Deoxycytidine8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
50.00Single8EF6Morphine8EF6-μ-Morphine-Gi1/&β;1/&γ;2
50.00Single8GEJEpinephrine8GEJ-β2-Epinephrine-Gs/&β;1/&γ;2
50.00Single8GH1Epinephrine8GH1-β2-Epinephrine
50.00Single8JJLOlodaterol8JJL-β2-Olodaterol
50.00Single8JLZST19368JLZ-5-HT6-ST1936-Gs/&β;1/&γ;2
50.00Single8JSOAMPH8JSO-TA1-AMPH-chim(NtGi1-Gs)/&β;1/&γ;2
50.00Single8W89PEA8W89-TA1-PEA-chim(NtGi1L-Gs)/&β;1/&γ;2
50.00Single8X63Mepyramine8X63-H1-Mepyramine
50.00Consensus5ht1f_onOrthosteric Ligand7EXD-5-HT1F-Lasmiditan-Gi1/&β;1/&γ;2
50.00Consensus5ht6_onOrthosteric Ligand7XTB-5-HT6-Serotonin-Gs/&β;1/&γ;2 8JLZ-5-HT6-ST1936-Gs/&β;1/&γ;2
50.00Consensusalpha_offOrthosteric Ligandalpha1_off alpha2_off
50.00Consensusdop_offOrthosteric Ligand4EJ4-δ-Naltrindole
50.00Consensusm2_on_alloOrthosteric Ligand7T94-M2-Acetylcholine-PubChem 57664406-chim(NtGi1-Go)/&β;1/&γ;2 6OIK-M2-Iperoxo-LY2119620-chim(NtGi1-Go)/&β;1/&γ;2
50.00Consensusm4_offOrthosteric Ligand5DSG-M4-Tiotropium
50.00Consensusm4_on_alloOrthosteric Ligand7TRP-M4-Iperoxo-LY2033298-Gi1/&β;1/&γ;2 7TRQ-M4-Iperoxo-VU0467154-Gi1/&β;1/&γ;2 7V68-M4-Iperoxo-PubChem 57664406-Gi1/&β;1/&γ;2
50.00Consensusmop_offOrthosteric Ligand7UL4-μ-Alvimopan 4DKL-μ-Beta-funaltrexamine 8QOT-μ-Nanobody E
50.00Consensusmop_onOrthosteric Ligand8F7Q-μ-Beta-endorphin-Gi1/&β;1/&γ;2 8EFQ-μ-Damgo-Gi1/&β;1/&γ;2 8F7R-μ-Endomorphin-Gi1/&β;1/&γ;2 8EF5-μ-Fentanyl-Gi1/&β;1/&γ;2 8EF6-μ-Morphine-Gi1/&β;1/&γ;2 8EFB-μ-Oliceridine-Gi1/&β;1/&γ;2 8EFO-μ-PZM21-Gi1/&β;1/&γ;2 8EFL-μ-SR17018-Gi1/&β;1/&γ;2
50.00Consensusmuscarinic_onOrthosteric Ligandm2_on m3_on m4_on m1_on
50.00Consensusopioid_offOrthosteric Ligandkop_off mop_off nop_off dop_off
47.37Single4IB4Ergotamine4IB4-5-HT2B-Ergotamine
47.37Single6HLOAprepitant6HLO-NK1-Aprepitant
47.06Single5TUDErgotamine5TUD-5-HT2B-Ergotamine
47.06Single5UNGPubChem 157800525UNG-AT2-PubChem 15780052
47.06Single5UNHPubChem 1264564065UNH-AT2-PubChem 126456406
47.06Single6BQGErgotamine6BQG-5-HT2C-Ergotamine
47.06Single6BQHRitanserin6BQH-5-HT2C-Ritanserin
47.06Single6G79Donitriptan6G79-5-HT1B-Donitriptan-Go/&β;1/&γ;2
47.06Single7X2DTavapadon7X2D-D1-Tavapadon-Gs/&β;1/&γ;2
47.06Consensus5ht2c_offOrthosteric Ligand6BQH-5-HT2C-Ritanserin
47.06Consensusclass-a_onOrthosteric Ligandsensory_on amine_on lipid_on nucleotide_on peptide_on protein_on hcar_on steroid_on melatonin_on
47.06Consensusendothelin_offOrthosteric Ligandetb_off
47.06Consensusetb_offOrthosteric Ligand5XPR-ETB-Bosentan 6K1Q-ETB-IRL2500 5X93-ETB-K-8794
47.06Consensusgi_class-aOrthosteric Ligandgi_amine gi_lipid gi_melatonin gi_peptide gi_protein gi_nucleotide gi_hcar
46.67Single5WQCEMPA5WQC-OX2-EMPA
46.67Single5ZK3Quinuclidinyl benzilate hydrobromide5ZK3-M2-Quinuclidinyl benzilate hydrobromide
46.67Single6OIKIperoxo6OIK-M2-Iperoxo-LY2119620-chim(NtGi1-Go)/&β;1/&γ;2
46.67Single7LD3Adenosine7LD3-A1-Adenosine-PubChem 25263603-Gi2/&β;1/&γ;2
46.67Single7SBFPZM217SBF-μ-PZM21-Gi1/&β;1/&γ;2
46.67Single7TRKIperoxo7TRK-M4-Iperoxo-Gi1/&β;1/&γ;2
46.67Single8C9WEtrumadenant8C9W-A2A-Etrumadenant
46.67Single8DZQmomSalB8DZQ-κ-momSalB-Go/&β;1/&γ;2
46.67Single8EA0Iperoxo8EA0-M3-Iperoxo
46.67Single8EFBOliceridine8EFB-μ-Oliceridine-Gi1/&β;1/&γ;2
46.67Single8HNLPS3724248HNL-CXCR3-PS372424-Gi1/&β;1/&γ;2
46.67Single8J19PubChem 1270454228J19-GPR84-PubChem 127045422-Gi1/&β;1/&γ;2
46.67Consensusa1_on_alloOrthosteric Ligand7LD3-A1-Adenosine-PubChem 25263603-Gi2/&β;1/&γ;2
46.67Consensusgo_opioidOrthosteric Ligand8DZQ-κ-momSalB-Go/&β;1/&γ;2
46.15Single2PED9-cis-Retinal2PED-Rhodopsin-9-cis-Retinal
46.15Single6AKXA4R6AKX-CCR5-A4R
46.15Single6AKYMaraviroc6AKY-CCR5-Maraviroc
46.15Single6ME2Ramelteon6ME2-MT1-Ramelteon
46.15Single6TODEMPA6TOD-OX1-EMPA-Na
46.15Single7EJ0L-Norepinephrine7EJ0-α2a-L-Norepinephrine-Go/&β;1/&γ;2
46.15Single7F1ODopamine7F1O-D1-Dopamine-GDP; Mg-Gs/&β;1/&γ;2
46.15Single7SRRLSD7SRR-5-HT2B-LSD-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
46.15Single7T8XAcetylcholine7T8X-M2-Acetylcholine-chim(NtGi1-Go)/&β;1/&γ;2
46.15Single7T90Acetylcholine7T90-M2-Acetylcholine-chim(NtGi1-Go)/&β;1/&γ;2
46.15Single8EFOPZM218EFO-μ-PZM21-Gi1/&β;1/&γ;2
46.15Single8GGFEpinephrine8GGF-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
46.15Single8HDPAdenosine8HDP-A2B-Adenosine-Gs/&β;1/&γ;2
46.15Single8HOCImetit8HOC-H4-Imetit-Gi1/&β;1/&γ;2
46.15Consensusgi_histamineOrthosteric Ligand8HN8-H4-Histamine-Gi1/&β;1/&γ;2 8HOC-H4-Imetit-Gi1/&β;1/&γ;2
46.15Consensusgs_histamineOrthosteric Ligand7YFC-H4-Histamine-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7YFD-H4-Imetit-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
46.15Consensush4_onOrthosteric Ligand7YFC-H4-Histamine-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7YFD-H4-Imetit-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
46.15Consensusm2_onOrthosteric Ligand7T8X-M2-Acetylcholine-chim(NtGi1-Go)/&β;1/&γ;2
45.45Single7MTBAll-trans-retinal7MTB-Rhodopsin-All-trans-retinal-GRK1
45.45Single8IWM2-Phenylethylamine8IWM-TAAR9-2-Phenylethylamine
45.45Single8WC5Tetramethylammonium ion8WC5-TA1-Tetramethylammonium ion-chim(NtGi1-Gs)/&β;1/&γ;2
45.45Consensushca2_on_alloOrthosteric Ligand8J6P-HCA2-Niacin-Compound 9n-Gi1/&β;1/&γ;2 8J6Q-HCA2-Beta-hydroxybutyrate-Compound 9n-Gi1/&β;1/&γ;2
45.45Consensussensory_onOrthosteric Ligandopsin_on
44.44Single6PT3DPI-2876PT3-δ-DPI-287
44.44Single7SK9CCX6627SK9-ACKR3-CCX662
43.75Single3UONQuinuclidinyl benzilate hydrobromide3UON-M2-Quinuclidinyl benzilate hydrobromide
43.75Single4IAQDihydroergotamine4IAQ-5-HT1B-Dihydroergotamine
43.75Single4RWDDIPP-NH24RWD-δ-DIPP-NH2-Na
43.75Single5X93K-87945X93-ETB-K-8794
43.75Single5ZHPPubChem 1348285895ZHP-M3-PubChem 134828589
43.75Single6GT3Imaradenant6GT3-A2A-Imaradenant-Na
43.75Single6J20Aprepitant6J20-NK1-Aprepitant
43.75Single6OIJIperoxo6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/&β;1/&γ;2
43.75Single7B6WCyclazosin7B6W-α1b-Cyclazosin
43.75Single7CKYPW04647CKY-D1-PW0464-Gs/&β;1/&γ;2
43.75Single7T2HLofentanil7T2H-μ-Lofentanil-Gi1/&β;1/&γ;2
43.75Single7U2LPubChem 1632012427U2L-μ-PubChem 163201242-Gi1/&β;1/&γ;2
43.75Single8DZPmomSalB8DZP-κ-momSalB-Gi1/&β;1/&γ;2
43.75Single8EF5Fentanyl8EF5-μ-Fentanyl-Gi1/&β;1/&γ;2
43.75Single8G056-OAU8G05-GPR84-6-OAU-Gi1/&β;1/&γ;2
43.75Single8JXVClozapine8JXV-H4-Clozapine-Gi1/&β;1/&γ;2
43.75Single8JXWVUF68848JXW-H4-VUF6884-Gi1/&β;1/&γ;2
43.75Single8JXXClobenpropit8JXX-H4-Clobenpropit-Gi1/&β;1/&γ;2
43.75Consensusa2b_onOrthosteric Ligand8HDP-A2B-Adenosine-Gs/&β;1/&γ;2 8HDO-A2B-BAY 60-6583-Gs/&β;1/&γ;2 7XY7-A2B-NECA-chim(NtGi1-Gs)/&β;1/&γ;2 7XY6-A2B-PubChem 11717831-chim(NtGi1-Gs)/&β;1/&γ;2
43.75Consensusalpha1b_offOrthosteric Ligand7B6W-α1b-Cyclazosin
43.75Consensusangiotensin_offOrthosteric Ligandat1_off at2_off
43.75Consensusgs_adenosineOrthosteric Ligand8HDP-A2B-Adenosine-Gs/&β;1/&γ;2 8HDO-A2B-BAY 60-6583-Gs/&β;1/&γ;2 6GDG-A2A-NECA-Gs/&β;1/&γ;1 7XY7-A2B-NECA-chim(NtGi1-Gs)/&β;1/&γ;2 7XY6-A2B-PubChem 11717831-chim(NtGi1-Gs)/&β;1/&γ;2
43.75Consensusgs_nucleotideOrthosteric Ligandgs_adenosine
42.86Single2YDOAdenosine2YDO-A2A-Adenosine
42.86Single3RZECidoxepin3RZE-H1-Cidoxepin
42.86Single3UZCPubChem 1355666093UZC-A2A-PubChem 135566609
42.86Single4DKLBeta-funaltrexamine4DKL-μ-Beta-funaltrexamine
42.86Single4MBSMaraviroc4MBS-CCR5-Maraviroc
42.86Single4N6HNaltrindole4N6H-δ-Naltrindole-Na
42.86Single4ZJCSB-6740424ZJC-OX1-SB-674042
42.86Single6ME42-Iodomelatonin6ME4-MT1-2-Iodomelatonin
42.86Single6TPNHTL66416TPN-OX2-HTL6641
42.86Single6VI4JDTic6VI4-κ-JDTic
42.86Single6ZFZ77-LH-28-16ZFZ-M1-77-LH-28-1
42.86Single7C61Ergotamine7C61-5-HT1B-Ergotamine
42.86Single7EJADexmedetomidine7EJA-α2a-Dexmedetomidine-Go/&β;1/&γ;2
42.86Single7SR8TAK-9257SR8-OX2-TAK-925-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
42.86Single7VUGJNJ-635330547VUG-GPR139-JNJ-63533054-Gi1/&β;1/&γ;2
42.86Single8FCZ11-cis-Retinal8FCZ-Rhodopsin-11-cis-Retinal
42.86Consensus5ht2a_offOrthosteric Ligand6A94-5-HT2A-Zotepine 6WH4-5-HT2A-Methiothepin 7VOE-5-HT2A-Aripiprazole 7VOD-5-HT2A-Cariprazine 7WC8-5-HT2A-Lumateperone 6A93-5-HT2A-Risperidone
42.86Consensusdop_off_alloOrthosteric Ligand4N6H-δ-Naltrindole-Na
42.86Consensusnop_offOrthosteric Ligand4EA3-NOP-PubChem 10296561 5DHG-NOP-PubChem 25001412 5DHH-NOP-SB-612111
42.86Consensusox1_offOrthosteric Ligand6TOT-OX1-Lemborexant 6TP4-OX1-ACT-462206 6TP6-OX1-Filorexant 6V9S-OX1-GTPL11403 6TP3-OX1-Nemorexant 6TQ6-OX1-PubChem 145714283 6TQ7-OX1-SB-334867 6TQ9-OX1-SB-408124 4ZJC-OX1-SB-674042 4ZJ8-OX1-Suvorexant
42.86Consensusox2_offOrthosteric Ligand6TPN-OX2-HTL6641 7XRR-OX2-Lemborexant
42.11Single5UNFPubChem 157800525UNF-AT2-PubChem 15780052
42.11Single7WVWfMYFINILTL7WVW-FPR2-ALX-fMYFINILTL-Gi2/&β;1/&γ;2
42.11Consensusgi_opioidOrthosteric Ligand8EF6-μ-Morphine-Gi1/&β;1/&γ;2 8F7Q-μ-Beta-endorphin-Gi1/&β;1/&γ;2 7U2K-μ-C6-guano-Gi1/&β;1/&γ;2 8EFQ-μ-Damgo-Gi1/&β;1/&γ;2 8F7S-δ-Deltorphin-Gi1/&β;1/&γ;2 8F7W-κ-Dynorphin-Gi1/&β;1/&γ;2 8F7R-μ-Endomorphin-Gi1/&β;1/&γ;2 8EF5-μ-Fentanyl-Gi1/&β;1/&γ;2 7SCG-μ-FH210-Gi1/&β;1/&γ;2 7T2H-μ-Lofentanil-Gi1/&β;1/&γ;2 7T2G-μ-Mitragynine pseudoindoxyl-Gi1/&β;1/&γ;2 8DZP-κ-momSalB-Gi1/&β;1/&γ;2 8F7X-NOP-Nociceptin-Gi1/&β;1/&γ;2 8EFB-μ-Oliceridine-Gi1/&β;1/&γ;2 8FEG-κ-PRD_002517-Gi1/&β;1/&γ;2 7U2L-μ-PubChem 163201242-Gi1/&β;1/&γ;2 8EFO-μ-PZM21-Gi1/&β;1/&γ;2 8EFL-μ-SR17018-Gi1/&β;1/&γ;2
41.67Single3UZAGTPL92363UZA-A2A-GTPL9236
41.67Single7F23Dopamine7F23-D1-Dopamine-GDP-Gs/&β;1/&γ;2
41.67Single8IW72-Phenylethylamine8IW7-TAAR9-2-Phenylethylamine-chim(NtGi1-Gs)/&β;1/&γ;2
41.67Single8J6QBeta-hydroxybutyrate8J6Q-HCA2-Beta-hydroxybutyrate-Compound 9n-Gi1/&β;1/&γ;2
41.67Single8JXTHistamine8JXT-H4-Histamine-PO4-Gi1/&β;1/&γ;2
41.67Consensusopsin_onOrthosteric Ligand6OYA-Rhodopsin-All-trans-retinal-Gt/&β;1/&γ;1
41.18Single6A93Risperidone6A93-5-HT2A-Risperidone
41.18Single6HLPNetupitant6HLP-NK1-Netupitant
41.18Single6ZG4HTL00099366ZG4-M1-HTL0009936
41.18Single7DFPSpiperone7DFP-D2-Spiperone
41.18Single7JNIOlodanrigan7JNI-AT2-Olodanrigan
41.18Single7X1TTaltirelin7X1T-TRH-Taltirelin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
41.18Single7XMTJ-21567XMT-SST4-J-2156-Gi1/&β;1/&γ;2
41.18Single7XY7NECA7XY7-A2B-NECA-chim(NtGi1-Gs)/&β;1/&γ;2
41.18Single8IJDMK68928IJD-HCA2-MK6892-Gi1/&β;1/&γ;2
41.18Single8JZ7MK68928JZ7-HCA2-MK6892-Gi1/&β;1/&γ;2
41.18Consensusat2_offOrthosteric Ligand7JNI-AT2-Olodanrigan
41.18Consensusgs_bileacidOrthosteric Ligand7CFN-GPBA-INT-777-Gs/&β;1/&γ;2 7CFM-GPBA-P395-Gs/&β;1/&γ;2 7XTQ-GPBA-R399-Gs/&β;1/&γ;2
41.18Consensusgs_steroidOrthosteric Ligandgs_bileacid
40.91Consensusgq_class-aOrthosteric Ligandgq_amine gq_peptide
40.00Single1HZX11-cis-Retinal1HZX-Rhodopsin-11-cis-Retinal
40.00Single3QAKUK-4320973QAK-A2A-UK-432097
40.00Single4J4QOctyl Beta-D-Glucopyranoside4J4Q-Rhodopsin-Octyl Beta-D-Glucopyranoside-Gt(CT)
40.00Single4X1HNonyl Beta-D-Glucopyranoside4X1H-Rhodopsin-Nonyl Beta-D-Glucopyranoside-Gt(CT)
40.00Single5DHGPubChem 250014125DHG-NOP-PubChem 25001412
40.00Single5OLZPubChem 1355666095OLZ-A2A-PubChem 135566609-Na
40.00Single5OM1PubChem 1355666095OM1-A2A-PubChem 135566609-Na
40.00Single6DRXLisuride6DRX-5-HT2B-Lisuride
40.00Single6TOTLemborexant6TOT-OX1-Lemborexant
40.00Single7CUMPhospholipid7CUM-GABAB1, GABAB2-CGP54626-Phospholipid
40.00Single7SCGFH2107SCG-μ-FH210-Gi1/&β;1/&γ;2
40.00Single7T6VfMLFII7T6V-FPR2-ALX-fMLFII-Gi1/&β;1/&γ;2
40.00Single7VH0Ramelteon7VH0-MT2-Ramelteon-Gi1/&β;1/&γ;1
40.00Single8CICEtrumadenant8CIC-A2A-Etrumadenant-Na
40.00Single8CU7LJ-45178CU7-A2A-LJ-4517-Na
40.00Single8DZSGR89,6968DZS-κ-GR89,696-chim(NtGi2-Gz)/&β;1/&γ;2
40.00Single8J18(3R)-3-hydroxydodecanoic acid8J18-GPR84-(3R)-3-hydroxydodecanoic acid-Gi1/&β;1/&γ;2
40.00Single8X17Namodenoson8X17-A3A-Namodenoson-Gi1/&β;1/&γ;2
40.00Consensusadenosine_onOrthosteric Liganda1_on a2_on
40.00Consensusgi_hcaOrthosteric Ligand8H2G-HCA2-Niacin-Gi1/&β;1/&γ;2 8IHJ-HCA3-Acifran-Gi1/&β;1/&γ;2 8IHI-HCA2-Acifran-Gi1/&β;1/&γ;2 8IHB-HCA2-GSK256073-Gi1/&β;1/&γ;2 8IHH-HCA2-LUF6283-Gi1/&β;1/&γ;2 8IHF-HCA2-MK6892-Gi1/&β;1/&γ;2 8JIM-HCA2-MMF-Gi1/&β;1/&γ;2 8IJB-HCA2-Acipimox-Gi1/&β;1/&γ;2 8IJD-HCA2-MK6892-Gi1/&β;1/&γ;2
40.00Consensusgi_hcarOrthosteric Ligandgi_hca
40.00Consensushca2_onOrthosteric Ligand8H2G-HCA2-Niacin-Gi1/&β;1/&γ;2 8IHI-HCA2-Acifran-Gi1/&β;1/&γ;2 8IHH-HCA2-LUF6283-Gi1/&β;1/&γ;2 8IHF-HCA2-MK6892-Gi1/&β;1/&γ;2 8JHY-HCA2-Compound 9n-Gi1/&β;1/&γ;2 8IHB-HCA2-GSK256073-Gi1/&β;1/&γ;2 8JIM-HCA2-MMF-Gi1/&β;1/&γ;2 8IJB-HCA2-Acipimox-Gi1/&β;1/&γ;2 8IJD-HCA2-MK6892-Gi1/&β;1/&γ;2 8J6J-HCA2-GSK256073-Gi1/&β;1/&γ;2
40.00Consensusnucleotide_onOrthosteric Ligandadenosine_on
40.00Consensustachykinin_offOrthosteric Ligandnk1_off
38.89Single4NC3Ergotamine4NC3-5-HT2B-Ergotamine
38.89Single6DDFDamgo6DDF-μ-Damgo-Gi1/&β;1/&γ;2
38.89Single7EZCUKA7EZC-A2A-UKA
38.89Single7SK7CCX6627SK7-ACKR3-CXCL12-CCX662
38.89Single7U2KC6-guano7U2K-μ-C6-guano-Gi1/&β;1/&γ;2
38.89Single7XK2MK68927XK2-HCA2-MK6892-Gi1/&β;1/&γ;2
38.89Single8T3OTUG-8918T3O-FFA4-TUG-891-2Y5-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
38.89Consensusbileacid_onOrthosteric Ligand7CFN-GPBA-INT-777-Gs/&β;1/&γ;2 7CFM-GPBA-P395-Gs/&β;1/&γ;2 7XTQ-GPBA-R399-Gs/&β;1/&γ;2
38.89Consensusffa4_on_alloOrthosteric Ligand8T3O-FFA4-TUG-891-2Y5-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
38.89Consensussteroid_onOrthosteric Ligandbileacid_on
38.46Single1U1911-cis-Retinal1U19-Rhodopsin-11-cis-Retinal
38.46Single2G87All-trans-retinal2G87-Rhodopsin-All-trans-retinal
38.46Single2I3511-cis-Retinal2I35-Rhodopsin-11-cis-Retinal
38.46Single6HLLCP999946HLL-NK1-CP99994
38.46Single6I9K9-cis-Retinal6I9K-Rhodopsin-9-cis-Retinal
38.46Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
38.46Single7YFCHistamine7YFC-H4-Histamine-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
38.46Single7YFDImetit7YFD-H4-Imetit-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
38.46Single8H2GNiacin8H2G-HCA2-Niacin-Gi1/&β;1/&γ;2
38.46Single8HN8Histamine8HN8-H4-Histamine-Gi1/&β;1/&γ;2
38.46Single8IJANiacin8IJA-HCA2-Niacin-Gi1/&β;1/&γ;2
38.46Single8ITFDMCHA8ITF-TAAR9-DMCHA-chim(NtGi1-Gs)/&β;1/&γ;2
38.46Single8IY9Niacin8IY9-HCA2-Niacin-Go/&β;1/&γ;2
38.46Single8K5BNiacin8K5B-HCA2-Niacin
38.46Consensusmt2_onOrthosteric Ligand7VH0-MT2-Ramelteon-Gi1/&β;1/&γ;1
38.46Consensusox1_off_alloOrthosteric Ligand6TOD-OX1-EMPA-Na 6TOS-OX1-GSK1059865-Na 6TQ4-OX1-PubChem 16046844-Na 6TO7-OX1-Suvorexant-Na
38.10Single5WF5UK-4320975WF5-A2A-UK-432097
38.10Single6PT2KGCHM076PT2-δ-KGCHM07
38.10Consensusgs_class-aOrthosteric Ligandgs_amine gs_nucleotide gs_lipid gs_peptide gs_protein gs_steroid
37.50Single4ZJ8Suvorexant4ZJ8-OX1-Suvorexant
37.50Single5OM4PubChem 1355666095OM4-A2A-PubChem 135566609-Na
37.50Single5XPRBosentan5XPR-ETB-Bosentan
37.50Single6DDEDamgo6DDE-μ-Damgo-Gi1/&β;1/&γ;2
37.50Single6GDGNECA6GDG-A2A-NECA-Gs/&β;1/&γ;1
37.50Single6LUQHaloperidol6LUQ-D2-Haloperidol
37.50Single6TO7Suvorexant6TO7-OX1-Suvorexant-Na
37.50Single6TP6Filorexant6TP6-OX1-Filorexant
37.50Single7CFNINT-7777CFN-GPBA-INT-777-Gs/&β;1/&γ;2
37.50Single7EUOfMLF7EUO-FPR1-ALX-fMLF-Gi1/&β;1/&γ;2
37.50Single7VOEAripiprazole7VOE-5-HT2A-Aripiprazole
37.50Single8J6JGSK2560738J6J-HCA2-GSK256073-Gi1/&β;1/&γ;2
37.50Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
37.50Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
37.50Consensusa2a_onOrthosteric Ligand6GDG-A2A-NECA-Gs/&β;1/&γ;1
37.50Consensusgq_muscarinicOrthosteric Ligand6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/&β;1/&γ;2
37.50Consensusm1_onOrthosteric Ligand6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/&β;1/&γ;2
36.84Single5WF6UK-4320975WF6-A2A-UK-432097
36.84Single7XN9L-054,5227XN9-SST2-L-054,522
36.84Single7XY6PubChem 117178317XY6-A2B-PubChem 11717831-chim(NtGi1-Gs)/&β;1/&γ;2
36.84Single8IYHMK68928IYH-HCA2-MK6892-Go/&β;1/&γ;2
36.84Consensusgi_lipidOrthosteric Ligandgi_cannabinoid gi_prostanoid gi_ffa gi_lpl gi_leukotriene
36.84Consensuslipid_onOrthosteric Ligandcannabinoid_on ffa_on gpr119_on leuko_on lpl_on prostanoid_on
36.36Single3PXOAll-trans-retinal3PXO-Rhodopsin-All-trans-retinal
36.36Single5DYSAll-trans-retinal5DYS-Rhodopsin-All-trans-retinal
36.36Single8IHFMK68928IHF-HCA2-MK6892-Gi1/&β;1/&γ;2
36.36Single8J6IMK68928J6I-HCA2-MK6892-Gi1/&β;1/&γ;2
36.36Consensusgabab_offOther Ligand7C7S-GABAB1, GABAB2-CGP54626 7CUM-GABAB1, GABAB2-CGP54626-Phospholipid 6W2X-GABAB1, GABAB2-PubChem 5311042-PubChem 23727970
35.71Single1F8811-cis-Retinal1F88-Rhodopsin-11-cis-Retinal
35.71Single1GZM11-cis-Retinal1GZM-Rhodopsin-11-cis-Retinal
35.71Single2X72All-trans-retinal2X72-Rhodopsin-All-trans-retinal-Gt(CT)
35.71Single3C9L11-cis-Retinal3C9L-Rhodopsin-11-cis-Retinal
35.71Single3VGAZM2413853VGA-A2A-ZM241385-Antibody
35.71Single5DHHSB-6121115DHH-NOP-SB-612111
35.71Single5WS3EMPA5WS3-OX2-EMPA
35.71Single6B73PubChem 1319551386B73-κ-PubChem 131955138
35.71Single6D9HAdenosine6D9H-A1-Adenosine-Gi2/&β;1/&γ;2
35.71Single6NWEOctyl Beta-D-Glucopyranoside6NWE-Rhodopsin-Octyl Beta-D-Glucopyranoside-Gt(CT)
35.71Single6OYAAll-trans-retinal6OYA-Rhodopsin-All-trans-retinal-Gt/&β;1/&γ;1
35.71Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
35.71Single7T6SPubChem 247763417T6S-FPR2-ALX-PubChem 24776341-Gi1/&β;1/&γ;2
35.71Single7VUJJNJ-635330547VUJ-GPR139-JNJ-63533054-GDP-chim(Gs-CtGq)/&β;1/&γ;2
35.71Consensusgt_class-aOrthosteric Ligandgt_opsin
35.71Consensusgt_opsinOrthosteric Ligandgt_sensory
35.71Consensusgt_sensoryOrthosteric Ligand6OYA-Rhodopsin-All-trans-retinal-Gt/&β;1/&γ;1
35.71Consensusmelatonin_onOrthosteric Ligandmt1_on mt2_on
35.71Consensusopsin_offOrthosteric Ligand1U19-Rhodopsin-11-cis-Retinal 2PED-Rhodopsin-9-cis-Retinal 5TE5-Rhodopsin-20-Methanoretinal
35.71Consensusorexin_offOrthosteric Ligandox2_off ox1_off
35.29Single4DJHJDTic4DJH-κ-JDTic
35.29Single6E59L-7607356E59-NK1-L-760735
35.29Single6KO5PubChem 574000026KO5-Ghrelin-PubChem 57400002
35.29Single7EW1Siponimod7EW1-S1P5-Siponimod-Gi1/&β;1/&γ;2
35.29Single7XTQR3997XTQ-GPBA-R399-Gs/&β;1/&γ;2
35.29Single8EFLSR170188EFL-μ-SR17018-Gi1/&β;1/&γ;2
35.29Single8HDOBAY 60-65838HDO-A2B-BAY 60-6583-Gs/&β;1/&γ;2
35.29Single8ID39-Hydroxystearic acid8ID3-FFA4 (GPR120)-9-Hydroxystearic acid-Gi1/&β;1/&γ;2
35.29Single8JD0J9R8JD0-mGlu2; mGlu3-Glutamate-J9R
35.29Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
35.29Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/&β;1/&γ;2
35.29Consensus5ht1b_onOrthosteric Ligand6G79-5-HT1B-Donitriptan-Go/&β;1/&γ;2
35.29Consensusgi_muscarinicOrthosteric Ligand7TRS-M4-Acetylcholine-Gi1/&β;1/&γ;2 7TRK-M4-Iperoxo-Gi1/&β;1/&γ;2 7V6A-M4-PubChem 9864275-Gi1/&β;1/&γ;2
35.29Consensuskop_offOrthosteric Ligand4DJH-κ-JDTic
35.29Consensuss1p5_onOrthosteric Ligand7EW1-S1P5-Siponimod-Gi1/&β;1/&γ;2
35.29Consensussst4_onOrthosteric Ligand7XMT-SST4-J-2156-Gi1/&β;1/&γ;2
35.00Single7W0PElabela7W0P-Apelin-Elabela-Gi1/&β;1/&γ;2
35.00Single7WKDTRH7WKD-TRH-TRH-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
35.00Single8G59TUG-8918G59-FFA4 (GPR120)-TUG-891-Gi1/&β;1/&γ;2
35.00Single8J6RMK68928J6R-HCA2-MK6892-Gi1/&β;1/&γ;2
35.00Consensusapelin_onOrthosteric Ligand7W0P-Apelin-Elabela-Gi1/&β;1/&γ;2 7W0M-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
34.78Single7YKDChemerin-97YKD-CML1-Chemerin-9-Gi1/&β;1/&γ;2
33.33Single3OAX11-cis-Retinal3OAX-Rhodopsin-11-cis-Retinal
33.33Single5TE3Octyl Beta-D-Glucopyranoside5TE3-Rhodopsin-Octyl Beta-D-Glucopyranoside
33.33Single6DO1Angiotensin-Like peptide S1I86DO1-AT1-Angiotensin-Like peptide S1I8
33.33Single6DS0Ly2660976DS0-5-HT2B-Ly266097
33.33Single6IQLL7458706IQL-D4-L745870
33.33Single6OY9All-trans-retinal6OY9-Rhodopsin-All-trans-retinal-Gt/&β;1/&γ;1
33.33Single6TOSGSK10598656TOS-OX1-GSK1059865-Na
33.33Single6V9SGTPL114036V9S-OX1-GTPL11403
33.33Single7F61PF-036547467F61-H3-PF-03654746-Cholesterol
33.33Single7L1VPubChem 1554910097L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
33.33Single7T32ZM2413857T32-A2A-ZM241385
33.33Single7W0LPubChem 1227019087W0L-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
33.33Single7WC9PubChem 1624213647WC9-5-HT2A-PubChem 162421364
33.33Single7WCNAR2314537WCN-GPR119-AR231453-Gs/&β;1/&γ;2
33.33Single7XW9TRH7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
33.33Single7ZBC11-cis-Retinal7ZBC-Rhodopsin-11-cis-Retinal
33.33Single8GURPubChem 1048958GUR-CB2-PubChem 104895-Gi1/&β;1/&γ;2
33.33Single8HNMVUF112228HNM-CXCR3-VUF11222-Gi1/&β;1/&γ;2
33.33Single8I95EP548I95-C3aB-EP54-Go/&β;1/&γ;2
33.33Single8J6PNiacin8J6P-HCA2-Niacin-Compound 9n-Gi1/&β;1/&γ;2
33.33Single8JERAcipimox8JER-HCA2-Acipimox-Go/&β;1/&γ;2
33.33Single8JHNMMF8JHN-HCA2-MMF-Go/&β;1/&γ;2
33.33Single8JIMMMF8JIM-HCA2-MMF-Gi1/&β;1/&γ;2
33.33Single8JWYPubChem 1684517108JWY-A2A-PubChem 168451710
33.33Single8JWZAB9288JWZ-A2A-AB928-Na
33.33Single8K5CAcipimox8K5C-HCA2-Acipimox
33.33Single8SG1Chemerin-98SG1-CML1-Chemerin-9-Gi1/&β;1/&γ;2
33.33Single8T3QDHA8T3Q-FFA4-DHA-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
33.33Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
33.33Single8WU1KCA8WU1-CB1-KCA-Arrestin1
33.33Consensusalpha1_offOrthosteric Ligandalpha1a_off alpha1b_off
33.33Consensusat1_offOrthosteric Ligand4YAY-AT1-ZD-7155 4ZUD-AT1-Olmesartan
33.33Consensuscannabinoid_offOrthosteric Ligandcb1_off cb2_off
33.33Consensusgi_melatoninOrthosteric Ligand7VGY-MT1-2-Iodomelatonin-Gi1/&β;1/&γ;2 7DB6-MT1-Ramelteon-Gi1/&β;1/&γ;2 7VH0-MT2-Ramelteon-Gi1/&β;1/&γ;1
33.33Consensusgs_trhOrthosteric Ligand7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
33.33Consensush3_on_alloOrthosteric Ligand7F61-H3-PF-03654746-Cholesterol
33.33Consensushca_onOrthosteric Ligandhca2_on hca3_on
33.33Consensushcar_onOrthosteric Ligandhca_on
33.33Consensuskop_onOrthosteric Ligand8F7W-κ-Dynorphin-Gi1/&β;1/&γ;2 8DZR-κ-GR89,696-chim(NtGi2-Gt3)/&β;1/&γ;2 8DZP-κ-momSalB-Gi1/&β;1/&γ;2 8FEG-κ-PRD_002517-Gi1/&β;1/&γ;2
33.33Consensusm4_onOrthosteric Ligand7TRS-M4-Acetylcholine-Gi1/&β;1/&γ;2 7TRK-M4-Iperoxo-Gi1/&β;1/&γ;2 8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/&β;1/&γ;2 7V6A-M4-PubChem 9864275-Gi1/&β;1/&γ;2
33.33Consensussensory_offOrthosteric Ligandopsin_off
33.33Consensustrh_onOrthosteric Ligand7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
32.00Single7WVYAmyloid-Beta427WVY-FPR2-ALX-Amyloid-Beta42-Gi2/&β;1/&γ;2
31.82Single7T6TfMLFII7T6T-FPR1-ALX-fMLFII-Gi1/&β;1/&γ;2
31.82Consensusangiotensin_onOrthosteric Ligandat1_on
31.82Consensusat1_onOrthosteric Ligand7F6G-AT1-SAR1-AngII-Gq/&β;1/&γ;2
31.82Consensusgi_chemerinOrthosteric Ligand8SG1-CML1-Chemerin-9-Gi1/&β;1/&γ;2
31.82Consensusopioid_onOrthosteric Ligandkop_on mop_on nop_on dop_on
31.58Single7EVZCenerimod7EVZ-S1P1-Cenerimod-Gi1/&β;1/&γ;2
31.58Single7EW0Ozanimod7EW0-S1P1-Ozanimod-Gi1/&β;1/&γ;2
31.58Single7MTSADX551647MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/&β;1/&γ;2
31.58Single7WVVfMLFII7WVV-FPR2-ALX-fMLFII-Gi2/&β;1/&γ;2
31.58Single7XAVLanreotide7XAV-SST2-Lanreotide-Gi1/&β;1/&γ;2
31.58Single7XZ6APD6687XZ6-GPR119-APD668-Gs/&β;1/&γ;2
31.58Single8K2XCXCL108K2X-CXCR3-CXCL10-Gi1/&β;1/&γ;2
31.58Consensusgs_orexinOrthosteric Ligand7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7SR8-OX2-TAK-925-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
31.58Consensusorexin_onOrthosteric Ligandox2_on
31.25Single4YAYZD-71554YAY-AT1-ZD-7155
31.25Single4ZUDOlmesartan4ZUD-AT1-Olmesartan
31.25Single5UIGJ3.651.884G5UIG-A2A-J3.651.884G
31.25Single7DB6Ramelteon7DB6-MT1-Ramelteon-Gi1/&β;1/&γ;2
31.25Single7EPFNAM5977EPF-mGlu2; mGlu2-NAM597
31.25Single7M3JNPS-2143; PO47M3J-CaS-NPS-2143; PO4
31.25Single7VIES1P7VIE-S1P1-S1P-Gi1/&β;1/&γ;2
31.25Single7VKTLTB47VKT-BLT1-LTB4-Gi1/&β;1/&γ;2
31.25Single7WC8Lumateperone7WC8-5-HT2A-Lumateperone
31.25Single8CU6LJ-45178CU6-A2A-LJ-4517
31.25Single8EFQDamgo8EFQ-μ-Damgo-Gi1/&β;1/&γ;2
31.25Single8I7VAcipimox8I7V-HCA2-Acipimox-Gi1/&β;1/&γ;2
31.25Single8I7WGSK2560738I7W-HCA2-GSK256073-Gi1/&β;1/&γ;2
31.25Single8JIINiacin8JII-HCA2-Niacin-Compound 9n-Gi1/&β;1/&γ;2
31.25Single8K5DGSK2560738K5D-HCA2-GSK256073
31.25Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/&β;1/&γ;2
31.25Consensusblt1_onOrthosteric Ligand7VKT-BLT1-LTB4-Gi1/&β;1/&γ;2
31.25Consensusblt_onOrthosteric Ligandblt1_on
31.25Consensusgi_leukotrieneOrthosteric Ligand7VKT-BLT1-LTB4-Gi1/&β;1/&γ;2
31.25Consensusleuko_onOrthosteric Ligandblt_on
30.77Single2J4Y11-cis-Retinal2J4Y-Rhodopsin-11-cis-Retinal
30.77Single3C9M11-cis-Retinal3C9M-Rhodopsin-11-cis-Retinal
30.77Single3PQRAll-trans-retinal3PQR-Rhodopsin-All-trans-retinal-Gt(CT)
30.77Single5WKTOctyl Beta-D-Glucopyranoside5WKT-Rhodopsin-Octyl Beta-D-Glucopyranoside-Gt(CT)
30.77Single6ME5Agomelatine6ME5-MT1-Agomelatine
30.77Single6ME9Ramelteon6ME9-MT2-Ramelteon
30.77Single7MT8All-trans-retinal7MT8-Rhodopsin-All-trans-retinal-GRK1
30.77Single7MT9All-trans-retinal7MT9-Rhodopsin-All-trans-retinal-GRK1
30.77Single7MTAAll-trans-retinal7MTA-Rhodopsin-All-trans-retinal-GRK1
30.77Single8IU2Retinal8IU2-Opsin1LW-Retinal-Gi1/&β;1/&γ;2
30.77Consensusgq_peptideOrthosteric Ligandgq_cck gq_angiotensin gq_bombesin gq_bradykinin
30.43Single7DW9Acyclovir triphosphate7DW9-V2-Acyclovir triphosphate-chim(NtGi1-Gs)/&β;1/&γ;2
30.43Single7F6GSAR1-AngII7F6G-AT1-SAR1-AngII-Gq/&β;1/&γ;2
30.43Single7W40Bombesin7W40-BB2-Bombesin-chim(NtGi1L-Gq)/&β;1/&γ;2
30.43Single8H4KGW95088H4K-FFA4-GW9508-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
30.43Consensusgq_angiotensinOrthosteric Ligand7F6G-AT1-SAR1-AngII-Gq/&β;1/&γ;2
30.43Consensusv2_onOrthosteric Ligand7DW9-V2-Acyclovir triphosphate-chim(NtGi1-Gs)/&β;1/&γ;2
30.00Single5ZTYAM102575ZTY-CB2-AM10257
30.00Single7X1UTRH7X1U-TRH-TRH-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
30.00Single7YJ4INSL57YJ4-RXFP4-INSL5-Gi2/&β;1/&γ;2
30.00Single8IA7Cholecystokinin-88IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/&β;1/&γ;2
30.00Consensuscb2_offOrthosteric Ligand5ZTY-CB2-AM10257
30.00Consensusdop_onOrthosteric Ligand8F7S-δ-Deltorphin-Gi1/&β;1/&γ;2
30.00Consensusgi_apelinOrthosteric Ligand7W0P-Apelin-Elabela-Gi1/&β;1/&γ;2 7W0M-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
30.00Consensusox2_onOrthosteric Ligand7L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7SR8-OX2-TAK-925-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
29.63Consensusbb2_onOrthosteric Ligand7W40-BB2-Bombesin-chim(NtGi1L-Gq)/&β;1/&γ;2 7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/&β;1/&γ;2
29.63Consensusgi_peptideOrthosteric Ligandgi_opioid gi_endothelin gi_formylpeptide gi_galanin gi_ghrelin gi_neuromedin gi_neurotensin gi_relaxin gi_neuropeptide gi_somatostatin gi_apelin gi_compl-peptide gi_cck
29.63Consensusgq_bombesinOrthosteric Ligand7W40-BB2-Bombesin-chim(NtGi1L-Gq)/&β;1/&γ;2 7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/&β;1/&γ;2
29.41Single4WW3All-trans-retinal4WW3-Rhodopsin-All-trans-retinal
29.41Single5CGCHTL142425CGC-mGlu5-HTL14242
29.41Single5NM2ZM2413855NM2-A2A-ZM241385-Na
29.41Single6D26Fevipiprant6D26-DP2-Fevipiprant
29.41Single6W2XPubChem 237279706W2X-GABAB1, GABAB2-PubChem 5311042-PubChem 23727970
29.41Single7EO2FTY720-P7EO2-S1P1-FTY720-P-Gi1/&β;1/&γ;2
29.41Single7EW3S1P7EW3-S1P3-S1P-Gi1/&β;1/&γ;2
29.41Single7M3JNPS-2143; PO47M3J-CaS-NPS-2143; PO4
29.41Single7SINNPS-21437SIN-CaS-NPS-2143
29.41Single7SINNPS-21437SIN-CaS-NPS-2143
29.41Single7VFXfMLF7VFX-FPR1-ALX-fMLF-Gi1/&β;1/&γ;2
29.41Single7VUHJNJ-635330547VUH-GPR139-JNJ-63533054-chim(Gs-CtGq)/&β;1/&γ;2
29.41Single7WIGL-054,2647WIG-SST2-L-054,264-Gi1/&β;1/&γ;2
29.41Single8IHJAcifran8IHJ-HCA3-Acifran-Gi1/&β;1/&γ;2
29.41Single8SZGCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-chim(NtGi1-Gq)/&β;1/&γ;2
29.41Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/&β;1/&γ;2
29.41Consensuscb2_onOrthosteric Ligand8GUS-CB2-HU-308-Gi1/&β;1/&γ;2 8GUT-CB2-LEI-102-Gi1/&β;1/&γ;2 8GUQ-CB2-Olorinab-Gi1/&β;1/&γ;2 8GUR-CB2-PubChem 104895-Gi1/&β;1/&γ;2 6KPF-CB2-PubChem 145915889-Gi1/&β;1/&γ;2 6PT0-CB2-WIN 55212-2-Gi1/&β;1/&γ;2
29.17Single7KH0Acyclovir triphosphate7KH0-V2-Acyclovir triphosphate-chim(NtGi1-Gs)/&β;1/&γ;2
29.17Consensusbk1_onOrthosteric Ligand7EIB-BK1-Des-Arg10-Kallidin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
29.17Consensusbombesin_onOrthosteric Ligandbb2_on bb1_on
28.57Single1L9H11-cis-Retinal1L9H-Rhodopsin-11-cis-Retinal
28.57Single3AYMAll-trans-retinal3AYM-Rhodopsin-All-trans-retinal
28.57Single5OLVLUAA410635OLV-A2A-LUAA41063-Na
28.57Single5TE520-Methanoretinal5TE5-Rhodopsin-20-Methanoretinal
28.57Single6QNOAll-trans-retinal6QNO-Rhodopsin-All-trans-retinal-Gi1/&β;1/&γ;1
28.57Single6TP4ACT-4622066TP4-OX1-ACT-462206
28.57Single6TQ4PubChem 160468446TQ4-OX1-PubChem 16046844-Na
28.57Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
28.57Single7F8XNN90567F8X-CCKA-NN9056
28.57Single7V68Iperoxo7V68-M4-Iperoxo-PubChem 57664406-Gi1/&β;1/&γ;2
28.57Single7WICSomatostatin-147WIC-SST2-Somatostatin-14-Gi1/&β;1/&γ;2
28.57Single8A2PLUAA470708A2P-A2A-LUAA47070-Na
28.57Single8JZZC5a-desArg8JZZ-C5a1-C5a-desArg-Go/&β;1/&γ;2
28.57Consensusalpha1a_offOrthosteric Ligand7YMJ-Alpha1A-Tamsulosin 8HN1-Alpha1A-Toxin AdTx1
28.57Consensusgo_class-aOrthosteric Ligandgo_amine go_peptide go_protein
28.57Consensusmt1_onOrthosteric Ligand7VGY-MT1-2-Iodomelatonin-Gi1/&β;1/&γ;2 7DB6-MT1-Ramelteon-Gi1/&β;1/&γ;2
28.57Consensussst_onOrthosteric Ligandsst2_on sst4_on
28.00Single7F8VGastrin-177F8V-CCKB-Gastrin-17-Gi2/&β;1/&γ;2
28.00Single8H0PNMB308H0P-BB1-NMB30-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
28.00Consensusbb1_onOrthosteric Ligand8H0P-BB1-NMB30-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
28.00Consensusgs_vasopressin-otOrthosteric Ligand7RYC-OT-Oxytocin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 7DW9-V2-Acyclovir triphosphate-chim(NtGi1-Gs)/&β;1/&γ;2
27.78Single5XR8AM8415XR8-CB1-AM841
27.78Single7EPENAM5637EPE-mGlu-NAM563
27.78Single7EW4CYM55417EW4-S1P3-CYM5541-Gi1/&β;1/&γ;2
27.78Single7EW7PubChem 40774607EW7-S1P1-PubChem 4077460-Gi1/&β;1/&γ;2
27.78Single7M8W15r-Methyl-Prostaglandin D27M8W-DP2-15r-Methyl-Prostaglandin D2-Na
27.78Single7TUYGSK682753A7TUY-GPR183-GSK682753A
27.78Single7W41PD1762527W41-BB2-PD176252
27.78Single7WVXHumanin7WVX-FPR2-ALX-Humanin-Gi2/&β;1/&γ;2
27.78Single8HPTC5a anaphylatoxin C-terminal peptide8HPT-C5a1-C5a anaphylatoxin C-terminal peptide-Go/&β;1/&γ;2
27.78Single8I9AEP548I9A-C3aB-EP54-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
27.78Single8ID6Oleic acid8ID6-FFA4 (GPR120)-Oleic acid-Gi1/&β;1/&γ;2
27.78Single8IHBGSK2560738IHB-HCA2-GSK256073-Gi1/&β;1/&γ;2
27.78Single8IHHLUF62838IHH-HCA2-LUF6283-Gi1/&β;1/&γ;2
27.78Single8IYWGSK2560738IYW-HCA2-GSK256073-Go/&β;1/&γ;2
27.78Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/&β;1/&γ;2
27.78Single8X16Piclidenoson8X16-A3A-Piclidenoson-Gi1/&β;1/&γ;2
27.78Single8XJMLatanoprost8XJM-FP-alpha-Latanoprost-chim(NtGi2-Gs-CtGq)/&β;1/&γ;2
27.78Consensusadenosine_offOrthosteric Liganda1_off a2_off
27.78Consensusarrestin2Orthosteric Ligand6TKO-β1-Arformoterol-Arrestin2 6PWC-NTS1-Neurotensin-Arrestin2 7R0C-V2-Acyclovir triphosphate-Arrestin2
27.78Consensusbb2_offOrthosteric Ligand7W41-BB2-PD176252
27.78Consensusbombesin_offOrthosteric Ligandbb2_off
27.78Consensusclass-a_offOrthosteric Ligandsensory_off amine_off lipid_off nucleotide_off peptide_off protein_off hcar_off
27.78Consensusffa4_onOrthosteric Ligand8H4K-FFA4-GW9508-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8ID9-FFA4 (GPR120)-Eicosapentaenoic acid-Gi1/&β;1/&γ;2 8ID4-FFA4 (GPR120)-Linoleic acid-Gi1/&β;1/&γ;2 8ID6-FFA4 (GPR120)-Oleic acid-Gi1/&β;1/&γ;2 8G59-FFA4 (GPR120)-TUG-891-Gi1/&β;1/&γ;2 8ID3-FFA4 (GPR120)-9-Hydroxystearic acid-Gi1/&β;1/&γ;2 8H4I-FFA4-Doconexent-chim(NtGi1-Gs)/&β;1/&γ;2
27.78Consensusgs_compl-peptideOrthosteric Ligand8I9A-C3aB-EP54-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
27.78Consensusgs_ffaOrthosteric Ligand8EIT-FFA1 (GPR40)-Doconexent-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2 8EJC-FFA1 (GPR40)-TAK-875-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2 8H4K-FFA4-GW9508-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8T3V-FFA1-DHA-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8T3S-FFA2-Butyric acid-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8T3Q-FFA4-DHA-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8GD9-EP4-Rivenprost-Gs/&β;1/&γ;2 8GDA-EP4-L902688-Gs/&β;1/&γ;2 8GDB-EP4-PGE2-Gs/&β;1/&γ;2
27.78Consensuss1p3_onOrthosteric Ligand7EW3-S1P3-S1P-Gi1/&β;1/&γ;2 7EW4-S1P3-CYM5541-Gi1/&β;1/&γ;2 7EW2-S1P3-Fingolimod-Gi1/&β;1/&γ;2
27.27Single4A4MAll-trans-retinal4A4M-Rhodopsin-All-trans-retinal-Gt(CT)
27.27Single5EN0All-trans-retinal5EN0-Rhodopsin-All-trans-retinal-Gt(CT)
27.27Single5MZPCaffeine5MZP-A2A-Caffeine-Na
27.27Single5XJM(Sar1,Ile8)-Angiotensin II5XJM-AT2-(Sar1,Ile8)-Angiotensin II
27.27Single7DDZJNJ-310200287DDZ-Y2-JNJ-31020028
27.27Single7WJ5Somatostatin-147WJ5-SST2-Somatostatin-14-Gi1/&β;1/&γ;2
27.27Single7XMSSomatostatin-147XMS-SST4-Somatostatin-14-Gi1/&β;1/&γ;2
27.27Single8F7SDeltorphin8F7S-δ-Deltorphin-Gi1/&β;1/&γ;2
27.27Single8WCBCyclohexylammonium ion8WCB-TA1-Cyclohexylammonium ion-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
27.27Single8WCCCyclohexylammonium ion8WCC-TA1-Cyclohexylammonium ion
27.27Consensusgi_lplOrthosteric Ligand7EW3-S1P3-S1P-Gi1/&β;1/&γ;2 7TD4-S1P1-Siponimod-Gi1/&β;1/&γ;2 7VIF-S1P1-(S)-FTY720-P-Gi1/&β;1/&γ;2 7EO4-S1P1-BAF312-Gi1/&β;1/&γ;2 7VIG-S1P1-CBP-307-Gi1/&β;1/&γ;2 7EVZ-S1P1-Cenerimod-Gi1/&β;1/&γ;2 7EW4-S1P3-CYM5541-Gi1/&β;1/&γ;2 7EW2-S1P3-Fingolimod-Gi1/&β;1/&γ;2 7TD0-LPA1-LPA-Gi1/&β;1/&γ;2 7YU3-LPA1-ONO-0740556-Gi1/&β;1/&γ;2 7EW0-S1P1-Ozanimod-Gi1/&β;1/&γ;2 7EW7-S1P1-PubChem 4077460-Gi1/&β;1/&γ;2
27.27Consensusnpy2_offOrthosteric Ligand7DDZ-Y2-JNJ-31020028
26.92Single7EIBDes-Arg10-Kallidin7EIB-BK1-Des-Arg10-Kallidin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
26.67Single2Z7311-cis-Retinal2Z73-Rhodopsin-11-cis-Retinal
26.67Single3AYN9-cis-Retinal3AYN-Rhodopsin-9-cis-Retinal
26.67Single4S0VSuvorexant4S0V-OX2-Suvorexant
26.67Single5K2DZM2413855K2D-A2A-ZM241385
26.67Single5OLHVipadenant5OLH-A2A-Vipadenant-Na
26.67Single5OLOTozadenant5OLO-A2A-Tozadenant-Na
26.67Single6JZHZM2413856JZH-A2A-ZM241385-Na
26.67Single6PS7ZM2413856PS7-A2A-ZM241385-Na
26.67Single6TPJSuvorexant6TPJ-OX2-Suvorexant
26.67Single7F8ULintitript7F8U-CCKA-Lintitript
26.67Single7M3ECa; Ca; Tryptophan; NPS-2143; PO47M3E-CaS-Ca; Ca; Tryptophan; NPS-2143; PO4
26.67Single7M3ECa; Ca; Tryptophan; NPS-2143; PO47M3E-CaS-Ca; Ca; Tryptophan; NPS-2143; PO4
26.67Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
26.67Single7TUZ7alpha,25-dihydroxycholesterol7TUZ-GPR183-7alpha,25-dihydroxycholesterol-Gi1/&β;1/&γ;2
26.67Single7VIHCBP-3077VIH-S1P1-CBP-307-Gi1/&β;1/&γ;2
26.67Single7XRRLemborexant7XRR-OX2-Lemborexant
26.67Single8A6CAll-trans-retinal8A6C-Rhodopsin-All-trans-retinal
26.67Single8A6DAll-trans-retinal8A6D-Rhodopsin-All-trans-retinal
26.67Single8A6EAll-trans-retinal8A6E-Rhodopsin-All-trans-retinal
26.67Single8DU3PubChem 1055260648DU3-A2A-PubChem 105526064
26.67Single8GNGIstradefylline8GNG-A2A-Istradefylline
26.67Single8IHKAcifran8IHK-HCA3-Acifran
26.67Single8IJBAcipimox8IJB-HCA2-Acipimox-Gi1/&β;1/&γ;2
26.67Single8J6LNiacin8J6L-HCA2-Niacin-Gi1/&β;1/&γ;2
26.67Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
26.67Consensusa2a_off_alloOrthosteric Ligand6ZDR-A2A-HMS1413f12-Na 6GT3-A2A-Imaradenant-Na 8CU7-A2A-LJ-4517-Na 5OLV-A2A-LUAA41063-Na 5N2R-A2A-PubChem 92460631; psb36-Na 5MZJ-A2A-Theophylline-Na 5OLO-A2A-Tozadenant-Na 5OLH-A2A-Vipadenant-Na 5NM4-A2A-ZM241385-Na 8GNE-A2A-KW-6356-Na 8JWZ-A2A-AB928-Na 5MZP-A2A-Caffeine-Na 8CIC-A2A-Etrumadenant-Na
26.32Single4OR2FITM4OR2-mGlu1; mGlu1-FITM
26.32Single4Z36ONO-30805734Z36-LPA1-ONO-3080573
26.32Single6OS0Angiotensinogen6OS0-AT1-Angiotensinogen
26.32Single6W2YPubChem 237279706W2Y-GABAB1; GABAB1-PubChem 5311042-PubChem 23727970
26.32Single6XBLCholesterol6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
26.32Single7EO4BAF3127EO4-S1P1-BAF312-Gi1/&β;1/&γ;2
26.32Single7EVYSiponimod7EVY-S1P1-Siponimod-Gi1/&β;1/&γ;2
26.32Single7EW2Fingolimod7EW2-S1P3-Fingolimod-Gi1/&β;1/&γ;2
26.32Single7K15MKD0467K15-BLT1-MKD046-Na
26.32Single7SUSPubChem 1227019087SUS-Apelin-PubChem 122701908
26.32Single7W0LPubChem 1227019087W0L-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
26.32Single7WCMMBX-29827WCM-GPR119-MBX-2982-Gs/&β;1/&γ;2
26.32Single7Y24Octreotide7Y24-SST2-Octreotide-Go/&β;1/&γ;2
26.32Single8IA8E7 peptide8IA8-C3aB-E7 peptide-Gi1/&β;1/&γ;2
26.32Consensusblt1_offOrthosteric Ligand7K15-BLT1-MKD046-Na
26.32Consensusblt_offOrthosteric Ligandblt1_off
26.32Consensuscannabinoid_onOrthosteric Ligandcb1_on cb2_on
26.32Consensuscb1_onOrthosteric Ligand8GHV-CB1-PubChem 145964903-Gi1/&β;1/&γ;2 6KPG-CB1-AM841-Gi1/&β;1/&γ;2 6N4B-CB1-MDMB-Fubinaca-Gi1/&β;1/&γ;2
26.32Consensusdp2_offOrthosteric Ligand6D27-DP2-CAY10471 6D26-DP2-Fevipiprant
26.32Consensusdp_offOrthosteric Liganddp2_off
26.32Consensusgi_cannabinoidOrthosteric Ligand8GUS-CB2-HU-308-Gi1/&β;1/&γ;2 8GUT-CB2-LEI-102-Gi1/&β;1/&γ;2 8GUQ-CB2-Olorinab-Gi1/&β;1/&γ;2 8GUR-CB2-PubChem 104895-Gi1/&β;1/&γ;2 6KPF-CB2-PubChem 145915889-Gi1/&β;1/&γ;2 6PT0-CB2-WIN 55212-2-Gi1/&β;1/&γ;2 6KPG-CB1-AM841-Gi1/&β;1/&γ;2 6N4B-CB1-MDMB-Fubinaca-Gi1/&β;1/&γ;2 8GHV-CB1-PubChem 145964903-Gi1/&β;1/&γ;2
26.32Consensusgi_class-fOther Ligandgi_frizzled
26.32Consensusgi_frizzledOther Ligand6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
26.32Consensusgpr119_onOrthosteric Ligand7XZ6-GPR119-APD668-Gs/&β;1/&γ;2 7WCN-GPR119-AR231453-Gs/&β;1/&γ;2 7XZ5-GPR119-Lysophosphatidylcholine-Gs/&β;1/&γ;2 7WCM-GPR119-MBX-2982-Gs/&β;1/&γ;2
26.32Consensusleuko_offOrthosteric Ligandblt_off cyslt_off
26.32Consensuslpa1_offOrthosteric Ligand4Z36-LPA1-ONO-3080573 4Z34-LPA1-ONO-9780307 4Z35-LPA1-ONO-9910539 7YU4-LPA1-ONO-0740556
26.32Consensuspeptide_offOrthosteric Ligandopioid_off angiotensin_off bombesin_off cck_off endothelin_off ghrelin_off npy_off nts_off orexin_off vasopressin-ot_off tachykinin_off sst_off
26.32Consensuss1p_onOrthosteric Ligands1p3_on s1p5_on s1p1_on s1p2_on
26.09Single7TD0LPA7TD0-LPA1-LPA-Gi1/&β;1/&γ;2
26.09Consensusgi_formylpeptideOrthosteric Ligand7VFX-FPR1-ALX-fMLF-Gi1/&β;1/&γ;2 7T6T-FPR1-ALX-fMLFII-Gi1/&β;1/&γ;2 7WVY-FPR2-ALX-Amyloid-Beta42-Gi2/&β;1/&γ;2 7T6U-FPR2-ALX-CGEN-855A-Gi1/&β;1/&γ;2 7WVV-FPR2-ALX-fMLFII-Gi2/&β;1/&γ;2 7WVW-FPR2-ALX-fMYFINILTL-Gi2/&β;1/&γ;2 7WVX-FPR2-ALX-Humanin-Gi2/&β;1/&γ;2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/&β;1/&γ;2 6OMM-FPR2-ALX-WKYMVX-Gi1/&β;1/&γ;2
25.93Consensusgq_bradykininOrthosteric Ligand7F6H-BK2-Bradykinin-Gq/&β;1/&γ;2 7F6I-BK2-Kallidin-Gq/&β;1/&γ;2
25.93Consensuspeptide_onOrthosteric Ligandopioid_on angiotensin_on bombesin_on cck_on endothelin_on ghrelin_on npy_on nts_on orexin_on vasopressin-ot_on tachykinin_on sst_on relaxin_on trh_on nmur_on motilin_on melanocortin_on galanin_on fpr-alx_on compl-peptide_on bradykinin_on apelin_on
25.00Single3REYPubChem 56973REY-A2A-PubChem 5697
25.00Single3V2YPubChem 518926453V2Y-S1P1-PubChem 51892645
25.00Single4OR2FITM4OR2-mGlu1; mGlu1-FITM
25.00Single4Z35ONO-99105394Z35-LPA1-ONO-9910539
25.00Single5CGDHTL142425CGD-mGlu5-HTL14242
25.00Single5IU4ZM2413855IU4-A2A-ZM241385-Na
25.00Single5IU7Q274563465IU7-A2A-Q27456346-Na
25.00Single5IUBQ274563445IUB-A2A-Q27456344-Na
25.00Single5JTBZM2413855JTB-A2A-ZM241385
25.00Single5K2BZM2413855K2B-A2A-ZM241385-Na
25.00Single5K2CZM2413855K2C-A2A-ZM241385-Na
25.00Single5MZJTheophylline5MZJ-A2A-Theophylline-Na
25.00Single5NLXZM2413855NLX-A2A-ZM241385-Na
25.00Single5NM4ZM2413855NM4-A2A-ZM241385-Na
25.00Single6AQFZM2413856AQF-A2A-ZM241385
25.00Single6JODAngiotensin II6JOD-AT2-Angiotensin II
25.00Single6TP3Nemorexant6TP3-OX1-Nemorexant
25.00Single6WI9Secretin6WI9-Secretin-Secretin-Gs/&β;1/&γ;2
25.00Single6ZDRHMS1413f126ZDR-A2A-HMS1413f12-Na
25.00Single6ZDVPubChem 9840736ZDV-A2A-PubChem 984073-Na
25.00Single6ZG9GSK10347026ZG9-M1-GSK1034702
25.00Single7AROLUF58337ARO-A2A-LUF5833-Na
25.00Single7BB6Acyclovir triphosphate7BB6-V2-Acyclovir triphosphate-Gs/&β;1/&γ;2
25.00Single7MBYCholecystokinin-87MBY-CCKA-Cholecystokinin-8-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
25.00Single7VODCariprazine7VOD-5-HT2A-Cariprazine
25.00Single7WC4Serotonin7WC4-5-HT2A-Serotonin
25.00Single7WVUfMLF7WVU-FPR1-ALX-fMLF-Gi1/&β;1/&γ;2
25.00Single7Y65C5a peptide7Y65-C5a1-C5a peptide-Gi1/&β;1/&γ;2
25.00Single7YK6PubChem 1383196747YK6-RXFP4-PubChem 138319674-Gi2/&β;1/&γ;2
25.00Single7ZBE11-cis-Retinal7ZBE-Rhodopsin-11-cis-Retinal
25.00Single8GAGYVF8GAG-CB1-YVF-Gi1/&β;1/&γ;2
25.00Single8GUQOlorinab8GUQ-CB2-Olorinab-Gi1/&β;1/&γ;2
25.00Single8HNKCXCL118HNK-CXCR3-CXCL11-Gi1/&β;1/&γ;2
25.00Single8ID8TUG-8918ID8-FFA4 (GPR120)-TUG-891-Gi1/&β;1/&γ;2
25.00Single8IULLatanoprost8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
25.00Single8IYSTUG-8918IYS-FFA4-TUG-891-GDP-chim(NtGi1L-Gq)/&β;1/&γ;2
25.00Single8JD3HZR; PEF8JD3-mGlu2; mGlu3-Glutamate-HZR; PEF-Gi1/&β;1/&γ;2
25.00Single8PWNTheophylline8PWN-A2A-Theophylline
25.00Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
25.00Consensusfpa_onOrthosteric Ligand8IUK-FP-alpha-PGF2-alpha-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
25.00Consensusgi_somatostatinOrthosteric Ligand7XMR-SST2-Somatostatin-14-Gi1/&β;1/&γ;2 7XMT-SST4-J-2156-Gi1/&β;1/&γ;2 7XAU-SST2-Octreotide-Gi1/&β;1/&γ;2 7YAC-SST2-Paltusotine-Gi1/&β;1/&γ;2
25.00Consensuss1p1_offOrthosteric Ligand3V2Y-S1P1-PubChem 51892645
25.00Consensuss1p1_onOrthosteric Ligand7TD3-S1P1-S1P-Gi1/&β;1/&γ;2 7TD4-S1P1-Siponimod-Gi1/&β;1/&γ;2 7VIF-S1P1-(S)-FTY720-P-Gi1/&β;1/&γ;2 7EO4-S1P1-BAF312-Gi1/&β;1/&γ;2 7VIG-S1P1-CBP-307-Gi1/&β;1/&γ;2 7EVZ-S1P1-Cenerimod-Gi1/&β;1/&γ;2 7EW0-S1P1-Ozanimod-Gi1/&β;1/&γ;2 7EW7-S1P1-PubChem 4077460-Gi1/&β;1/&γ;2
25.00Consensuss1p_offOrthosteric Ligands1p1_off
24.00Single7F6HBradykinin7F6H-BK2-Bradykinin-Gq/&β;1/&γ;2
24.00Single7QBIAlpha-factor mating pheromone7QBI-STE2-Alpha-factor mating pheromone
24.00Single7X9CPancreatic Hormone7X9C-Y4-Pancreatic Hormone-Gi1/&β;1/&γ;2
24.00Single7XATSomatostatin-147XAT-SST2-Somatostatin-14-Gi1/&β;1/&γ;2
24.00Consensusgs_bradykininOrthosteric Ligand7F2O-BK2-Bradykinin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7EIB-BK1-Des-Arg10-Kallidin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
23.81Single5EE7MK08935EE7-Glucagon-MK0893
23.81Single6XBJCholesterol6XBJ-SMO-Cholesterol-Gi1/&β;1/&γ;2
23.81Single7F2OBradykinin7F2O-BK2-Bradykinin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
23.81Single7F8WGastrin-177F8W-CCKB-Gastrin-17-chim(NtGsL-Gq)/&β;1/&γ;2
23.81Single7MTRADX551647MTR-mGlu2; mGlu2-Glutamate-ADX55164
23.81Single7YAEOctreotide7YAE-SST2-Octreotide-Gi1/&β;1/&γ;2
23.81Single8F7REndomorphin8F7R-μ-Endomorphin-Gi1/&β;1/&γ;2
23.81Single8H4IDoconexent8H4I-FFA4-Doconexent-chim(NtGi1-Gs)/&β;1/&γ;2
23.81Single8IUMTafluprost acid8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
23.81Single8XZFWN5618XZF-Apelin-WN561-Gi1/&β;1/&γ;2
23.81Consensusc3a_onOrthosteric Ligand8HK2-C3aB-C3a anaphylatoxin-Gi1/&β;1/&γ;2 8IA8-C3aB-E7 peptide-Gi1/&β;1/&γ;2 8J6D-C3aB-EP141-Go/&β;1/&γ;2 8I95-C3aB-EP54-Go/&β;1/&γ;2
23.81Consensusfpr1-alx_onOrthosteric Ligand7VFX-FPR1-ALX-fMLF-Gi1/&β;1/&γ;2 7T6T-FPR1-ALX-fMLFII-Gi1/&β;1/&γ;2
23.81Consensusfpr2-alx_onOrthosteric Ligand7WVY-FPR2-ALX-Amyloid-Beta42-Gi2/&β;1/&γ;2 7T6U-FPR2-ALX-CGEN-855A-Gi1/&β;1/&γ;2 7WVV-FPR2-ALX-fMLFII-Gi2/&β;1/&γ;2 7WVW-FPR2-ALX-fMYFINILTL-Gi2/&β;1/&γ;2 7WVX-FPR2-ALX-Humanin-Gi2/&β;1/&γ;2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/&β;1/&γ;2 6OMM-FPR2-ALX-WKYMVX-Gi1/&β;1/&γ;2
23.81Consensuslpl_offOrthosteric Ligands1p_off lpa_off
23.81Consensuslpl_onOrthosteric Ligands1p_on lpa_on
23.53Single3EMLZM2413853EML-A2A-ZM241385
23.53Single4EIYZM2413854EIY-A2A-ZM241385-Na
23.53Single5IU8Q274563475IU8-A2A-Q27456347-Na
23.53Single5K2AZM2413855K2A-A2A-ZM241385-Na
23.53Single5OLGZM2413855OLG-A2A-ZM241385-Na
23.53Single5TGZAM65385TGZ-CB1-AM6538
23.53Single5UENDU1725UEN-A1-DU172
23.53Single5VRAZM2413855VRA-A2A-ZM241385-Na
23.53Single5ZKPForopafant (SR27417)5ZKP-PAF-Foropafant (SR27417)
23.53Single6D27CAY104716D27-DP2-CAY10471
23.53Single6GPSMK08126GPS-CCR2-MK0812
23.53Single6KPFPubChem 1459158896KPF-CB2-PubChem 145915889-Gi1/&β;1/&γ;2
23.53Single6LPJZM2413856LPJ-A2A-ZM241385-Na
23.53Single6LPKZM2413856LPK-A2A-ZM241385-Na
23.53Single6S0LZM2413856S0L-A2A-ZM241385
23.53Single6XBM25(S)-Epoxycholesterol6XBM-SMO-25(S)-Epoxycholesterol-Gi1/&β;1/&γ;2
23.53Single6Z10PubChem 1545855546Z10-Succinate-PubChem 154585554
23.53Single7CFMP3957CFM-GPBA-P395-Gs/&β;1/&γ;2
23.53Single7PYRPSB-21157PYR-A2A-PSB-2115
23.53Single7V3ZPubMed 1048957V3Z-CB1-PubMed 104895
23.53Single7VIF(S)-FTY720-P7VIF-S1P1-(S)-FTY720-P-Gi1/&β;1/&γ;2
23.53Single7YK7DC5910537YK7-RXFP4-DC591053-Gi2/&β;1/&γ;2
23.53Single8ID4Linoleic acid8ID4-FFA4 (GPR120)-Linoleic acid-Gi1/&β;1/&γ;2
23.53Single8JT8(R)-IHCH-71798JT8-5-HT2A-(R)-IHCH-7179
23.53Consensusa2_offOrthosteric Liganda2a_off
23.53Consensusa2a_offOrthosteric Ligand8C9W-A2A-Etrumadenant 3UZA-A2A-GTPL9236 8GNG-A2A-Istradefylline 5UIG-A2A-J3.651.884G 8CU6-A2A-LJ-4517 7PX4-A2A-PSB-2113 7PYR-A2A-PSB-2115 8DU3-A2A-PubChem 105526064 8JWY-A2A-PubChem 168451710 5K2D-A2A-ZM241385
23.53Consensuscb1_on_alloOrthosteric Ligand7WV9-CB1-PubMed 104895-ZCZ011-Gi2/&β;1/&γ;2
23.53Consensushca3_onOrthosteric Ligand8IHJ-HCA3-Acifran-Gi1/&β;1/&γ;2
23.53Consensusnucleotide_offOrthosteric Ligandadenosine_off p2y_off
23.08Single2HPYAll-trans-retinal2HPY-Rhodopsin-All-trans-retinal
23.08Single3RFMCaffeine3RFM-A2A-Caffeine
23.08Single6TQ9SB-4081246TQ9-OX1-SB-408124
23.08Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
23.08Single7QBIAlpha-factor mating pheromone7QBI-STE2-Alpha-factor mating pheromone
23.08Single7RGPTirzepatide7RGP-GLP-1-Tirzepatide-chim(NtGi1-Gs)/&β;1/&γ;2
23.08Single8A2OTheophylline8A2O-A2A-Theophylline-Na
23.08Consensusbradykinin_onOrthosteric Ligandbk2_on bk1_on
23.08Consensusnpy4_onOrthosteric Ligand7X9C-Y4-Pancreatic Hormone-Gi1/&β;1/&γ;2
22.73Single7F4ISHU91197F4I-MC1-SHU9119-chim(NtGi1-Gs)/&β;1/&γ;2
22.73Single7QA8Peptide7QA8-STE2-Peptide
22.73Single7QA8Peptide7QA8-STE2-Peptide
22.73Single7T6UCGEN-855A7T6U-FPR2-ALX-CGEN-855A-Gi1/&β;1/&γ;2
22.73Single8F7XNociceptin8F7X-NOP-Nociceptin-Gi1/&β;1/&γ;2
22.73Single8GHVPubChem 1459649038GHV-CB1-PubChem 145964903-Gi1/&β;1/&γ;2
22.73Consensusclass-d_offOrthosteric Ligandste2_off
22.73Consensusfpr-alx_onOrthosteric Ligandfpr1-alx_on fpr2-alx_on
22.73Consensusgi_relaxinOrthosteric Ligand7YK7-RXFP4-DC591053-Gi2/&β;1/&γ;2 7YJ4-RXFP4-INSL5-Gi2/&β;1/&γ;2 7YK6-RXFP4-PubChem 138319674-Gi2/&β;1/&γ;2
22.73Consensusnop_onOrthosteric Ligand8F7X-NOP-Nociceptin-Gi1/&β;1/&γ;2
22.73Consensussst2_onOrthosteric Ligand7XMR-SST2-Somatostatin-14-Gi1/&β;1/&γ;2 7XAU-SST2-Octreotide-Gi1/&β;1/&γ;2 7YAC-SST2-Paltusotine-Gi1/&β;1/&γ;2
22.58Consensusgi_neuropeptideOrthosteric Ligand7YOO-Y2-Neuropeptide Y-Gi1/&β;1/&γ;2 7YON-Y2-Peptide YY(3-36)-Gi1/&β;1/&γ;2 7X9C-Y4-Pancreatic Hormone-Gi1/&β;1/&γ;2 7X9A-Y1-Neuropeptide Y-Gi1/&β;1/&γ;2
22.58Consensusnpy1_onOrthosteric Ligand7X9A-Y1-Neuropeptide Y-Gi1/&β;1/&γ;2
22.58Consensusnpy_onOrthosteric Ligandnpy2_on npy4_on npy1_on
22.22Single5IUAQ274563485IUA-A2A-Q27456348-Na
22.22Single5N2RPubChem 92460631; psb365N2R-A2A-PubChem 92460631; psb36-Na
22.22Single5N2SPSB365N2S-A1-PSB36
22.22Single5ZBQUR-MK-2995ZBQ-Y1-UR-MK-299
22.22Single6GPXMK08126GPX-CCR2-MK0812
22.22Single6KPCPubChem 1459158896KPC-CB2-PubChem 145915889
22.22Single6LPLZM2413856LPL-A2A-ZM241385-Na
22.22Single6S0QZM2413856S0Q-A2A-ZM241385
22.22Single6WQAZM2413856WQA-A2A-ZM241385-Na
22.22Single7BB7Acyclovir triphosphate7BB7-V2-Acyclovir triphosphate-Gs/&β;1/&γ;2
22.22Single7C4SS1P7C4S-S1P3-S1P
22.22Single7F4FAfamelanotide7F4F-MC1-Afamelanotide-chim(NtGi1-Gs)/&β;1/&γ;2
22.22Single7QBCAlpha-factor mating pheromone7QBC-STE2-Alpha-factor mating pheromone
22.22Single7RM5ZM2413857RM5-A2A-ZM241385-Na
22.22Single7TD3S1P7TD3-S1P1-S1P-Gi1/&β;1/&γ;2
22.22Single8FYNZM2413858FYN-A2A-ZM241385-Na
22.22Single8GD9Rivenprost8GD9-EP4-Rivenprost-Gs/&β;1/&γ;2
22.22Single8GNEKW-63568GNE-A2A-KW-6356-Na
22.22Single8ID9Eicosapentaenoic acid8ID9-FFA4 (GPR120)-Eicosapentaenoic acid-Gi1/&β;1/&γ;2
22.22Single8K8JFenofibrate8K8J-CB1-Fenofibrate-chim(Gs-CtGq)/&β;1/&γ;2
22.22Single8KFXLMD-0098KFX-CCR8-LMD-009-Gi1/&β;1/&γ;2
22.22Single8QOTNanobody E8QOT-μ-Nanobody E
22.22Consensusa1_offOrthosteric Ligand5UEN-A1-DU172 5N2S-A1-PSB36
22.22Consensusendothelin_onOrthosteric Ligandetb_on eta_on
22.22Consensusgo_class-b1Orthosteric Ligandgo_crf
22.22Consensusgo_crfOrthosteric Ligand7TS0-CRF2-Urocortin-chim(NtGi1L-Go)/&β;1/&γ;2
22.22Consensusrxfp4_onOrthosteric Ligand7YK7-RXFP4-DC591053-Gi2/&β;1/&γ;2 7YJ4-RXFP4-INSL5-Gi2/&β;1/&γ;2 7YK6-RXFP4-PubChem 138319674-Gi2/&β;1/&γ;2
21.74Single7CUMPhospholipid7CUM-GABAB1, GABAB2-CGP54626-Phospholipid
21.74Single7EZKCholecystokinin-87EZK-CCKA-Cholecystokinin-8-chim(NtGi1-Gs)/&β;1/&γ;2
21.74Single7RKMFractalkine7RKM-US28-Fractalkine-Gi1/&β;1/&γ;2
21.74Single7W0NElabela7W0N-Apelin-Elabela-Gi1/&β;1/&γ;2
21.74Single8F7WDynorphin8F7W-κ-Dynorphin-Gi1/&β;1/&γ;2
21.74Consensusgi_cckOrthosteric Ligand7EZH-CCKA-Cholecystokinin-8-Gi1/&β;1/&γ;2 7F8V-CCKB-Gastrin-17-Gi2/&β;1/&γ;2
21.43Single6B3JExendin-P56B3J-GLP-1-Exendin-P5-Gs/&β;1/&γ;2
21.43Single6IGLIRL16206IGL-ETB-IRL1620
21.43Single7QBCAlpha-factor mating pheromone7QBC-STE2-Alpha-factor mating pheromone
21.43Single7VGXNeuropeptide Y7VGX-Y1-Neuropeptide Y-Gi1/&β;1/&γ;2
21.43Single7WC5Psilocin7WC5-5-HT2A-Psilocin
21.43Single8EITDoconexent8EIT-FFA1 (GPR40)-Doconexent-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
21.43Single8F76-8F76-OR51E2-Gs/&β;1/&γ;2
21.43Single8FEGPRD_0025178FEG-κ-PRD_002517-Gi1/&β;1/&γ;2
21.43Single8IY5Endothelin-18IY5-ETB-Endothelin-1-Gi1/&β;1/&γ;2
21.43Single8J21Butyric acid8J21-FFA3-Butyric acid-Gi1/&β;1/&γ;2
21.43Single8J24Acetic acid8J24-FFA2-Acetic acid-Gi1/&β;1/&γ;2
21.43Consensuscrf1_onOrthosteric Ligand6P9X-CRF1-Corticoliberin-Gs/&β;1/&γ;2
21.43Consensusffa3_onOrthosteric Ligand8J21-FFA3-Butyric acid-Gi1/&β;1/&γ;2
21.43Consensusgs_endothelinOrthosteric Ligand8HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8HCX-ETB-Endothelin-1-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
21.43Consensusgs_peptideOrthosteric Ligandgs_cck gs_motilin gs_neuromedin gs_orexin gs_sst gs_tachykinin gs_trh gs_vasopressin-ot gs_bombesin gs_bradykinin gs_compl-peptide gs_endothelin gs_galanin gs_ghrelin gs_melanocortin
21.05Single4OO9Mavoglurant4OO9-mGlu5-Mavoglurant
21.05Single4Z34ONO-97803074Z34-LPA1-ONO-9780307
21.05Single5XRAAM115425XRA-CB1-AM11542
21.05Single6O3CCholesterol6O3C-SMO-SAG21k-Cholesterol
21.05Single7PX4PSB-21137PX4-A2A-PSB-2113
21.05Single7TD1LPA7TD1-LPA1-LPA-Gi1/&β;1/&γ;2
21.05Single7VIGCBP-3077VIG-S1P1-CBP-307-Gi1/&β;1/&γ;2
21.05Single7WV9PubMed 1048957WV9-CB1-PubMed 104895-ZCZ011-Gi2/&β;1/&γ;2
21.05Single8GUSHU-3088GUS-CB2-HU-308-Gi1/&β;1/&γ;2
21.05Single8IUKPGF2-alpha8IUK-FP-alpha-PGF2-alpha-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
21.05Single8X79MRE-2698X79-I2-MRE-269-Gs/&β;1/&γ;2
21.05Consensuscck_onOrthosteric Ligandccka_on cckb_on
21.05Consensusccka_onOrthosteric Ligand7EZH-CCKA-Cholecystokinin-8-Gi1/&β;1/&γ;2 7XOV-CCKA-SR146131-Gs/&β;1/&γ;2
21.05Consensuschemerin_onOrthosteric Ligandcml1_on
21.05Consensuscml1_onOrthosteric Ligand8SG1-CML1-Chemerin-9-Gi1/&β;1/&γ;2
21.05Consensuscyslt1_off_ortoalloOrthosteric Ligand6RZ5-CysLT1-Zafirlukast-Na 6RZ4-CysLT1-Pranlukast-Na
21.05Consensusgi_ffaOrthosteric Ligand8ID6-FFA4 (GPR120)-Oleic acid-Gi1/&β;1/&γ;2 8G59-FFA4 (GPR120)-TUG-891-Gi1/&β;1/&γ;2 8ID3-FFA4 (GPR120)-9-Hydroxystearic acid-Gi1/&β;1/&γ;2 8ID9-FFA4 (GPR120)-Eicosapentaenoic acid-Gi1/&β;1/&γ;2 8ID4-FFA4 (GPR120)-Linoleic acid-Gi1/&β;1/&γ;2 8J22-FFA2-TUG-1375-Gi1/&β;1/&γ;2 8J24-FFA2-Acetic acid-Gi1/&β;1/&γ;2 8J21-FFA3-Butyric acid-Gi1/&β;1/&γ;2
21.05Consensuslpa1_onOrthosteric Ligand7TD0-LPA1-LPA-Gi1/&β;1/&γ;2 7YU3-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
21.05Consensuslpa_offOrthosteric Ligandlpa1_off
21.05Consensuslpa_onOrthosteric Ligandlpa1_on
21.05Consensusnpy1_offOrthosteric Ligand5ZBH-Y1-BMS-193885 5ZBQ-Y1-UR-MK-299
21.05Consensusnpy_offOrthosteric Ligandnpy2_off npy1_off
21.05Consensusrelaxin_onOrthosteric Ligandrxfp4_on
20.83Single6LW5WKYMVm6LW5-FPR2-ALX-WKYMVm
20.83Single6VN7PACAP6VN7-VPAC1-PACAP-Gs/&β;1/&γ;2
20.83Single7MBXCholecystokinin-87MBX-CCKA-Cholecystokinin-8-Gs/&β;1/&γ;1
20.83Single7TD2LPA7TD2-LPA1-LPA-Gi1/&β;1/&γ;2
20.83Single7XAUOctreotide7XAU-SST2-Octreotide-Gi1/&β;1/&γ;2
20.83Single7XOUCholecystokinin-87XOU-CCKA-Cholecystokinin-8-Gs/&β;1/&γ;2
20.83Single8XZGApelin-138XZG-Apelin-Apelin-13-Gi1/&β;1/&γ;2
20.83Single8XZHMM078XZH-Apelin-MM07-Gi1/&β;1/&γ;2
20.69Single5GLHEndothelin-15GLH-ETB-Endothelin-1
20.69Single6IGKEndothelin-36IGK-ETB-Endothelin-3
20.69Single6PB0Urocortin6PB0-CRF1-Urocortin-chim(NtGi1-Gs)/&β;1/&γ;2
20.69Single7TS0Urocortin7TS0-CRF2-Urocortin-chim(NtGi1L-Go)/&β;1/&γ;2
20.00Single3OE9IT1t3OE9-CXCR4-IT1t
20.00Single3V2WPubChem 518926453V2W-S1P1-PubChem 51892645
20.00Single4N4WSANT-14N4W-SMO-SANT-1
20.00Single5WB2CX3CL1.355WB2-US28-CX3CL1.35
20.00Single6LPBPACAP6LPB-PAC1-PACAP-Gs/&β;1/&γ;1
20.00Single6PGSGeraniol6PGS-Rhodopsin-Geraniol-Gt(CT)
20.00Single6WIVPubChem 52923113; PubChem 529246456WIV-GABAB1, GABAB2-PubChem 52923113; PubChem 52924645
20.00Single7AD3Alpha-factor mating pheromone7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
20.00Single7FIMTirzepatide7FIM-GLP-1-Tirzepatide-Gs/&β;1/&γ;2
20.00Single7L1UOrexin7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
20.00Single7RYCOxytocin7RYC-OT-Oxytocin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
20.00Single7VUIJNJ-635330547VUI-GPR139-JNJ-63533054-GTP-chim(Gs-CtGq)/&β;1/&γ;2
20.00Single7WUIIP157WUI-ADGRG2-IP15-chim(NtGi1-Gs)/&β;1/&γ;2
20.00Single7XZ5Lysophosphatidylcholine7XZ5-GPR119-Lysophosphatidylcholine-Gs/&β;1/&γ;2
20.00Single8GCPPGE28GCP-EP4-PGE2-Gi1/&β;1/&γ;2
20.00Single8I9LC3a anaphylatoxin8I9L-C3aB-C3a anaphylatoxin-Go/&β;1/&γ;2
20.00Single8IHIAcifran8IHI-HCA2-Acifran-Gi1/&β;1/&γ;2
20.00Single8J22TUG-13758J22-FFA2-TUG-1375-Gi1/&β;1/&γ;2
20.00Single8J6DEP1418J6D-C3aB-EP141-Go/&β;1/&γ;2
20.00Single8JILNiacin8JIL-HCA2-Niacin-Gi1/&β;1/&γ;2
20.00Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
20.00Consensusbk2_onOrthosteric Ligand7F2O-BK2-Bradykinin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7F6I-BK2-Kallidin-Gq/&β;1/&γ;2
20.00Consensusclass-d_onOrthosteric Ligandste2_on
20.00Consensusgi_class-dOrthosteric Ligandgi_ste
20.00Consensusgi_endothelinOrthosteric Ligand8IY5-ETB-Endothelin-1-Gi1/&β;1/&γ;2 8HBD-ETB-IRL1620-Gi1/&β;1/&γ;2
20.00Consensusgi_prostanoidOrthosteric Ligand8GCP-EP4-PGE2-Gi1/&β;1/&γ;2 8GDC-EP3-PGE2-Gi1/&β;1/&γ;2 8GCM-EP4-L902688-Gi1/&β;1/&γ;2
20.00Consensusgi_steOrthosteric Ligand7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
20.00Consensusprostanoid_onOrthosteric Ligandep_on fpa_on
19.35Single6LRYSarafotoxin-B6LRY-ETB-Sarafotoxin-B
19.23Single6UUNAdrenomedullin6UUN-CT Like (AM1)-Adrenomedullin-Gs/&β;1/&γ;2; RAMP2
19.23Single7F6IKallidin7F6I-BK2-Kallidin-Gq/&β;1/&γ;2
19.23Single7V9MSomatoliberin7V9M-GHRH (SV1)-Somatoliberin-Gs/&β;1/&γ;2
19.23Single7WBJPACAP277WBJ-VPAC1-PACAP27-Gs/&β;1/&γ;2
19.23Single7X9BNeuropeptide Y7X9B-Y2-Neuropeptide Y-Gi1/&β;1/&γ;2
19.23Single7Y64C5a anaphylatoxin7Y64-C5a1-C5a anaphylatoxin-Gi1/&β;1/&γ;2
19.23Single8E3YPACAP278E3Y-VPAC1-PACAP27-Gs/&β;1/&γ;2
19.23Single8E3ZVIP8E3Z-VPAC1-VIP-Gs/&β;1/&γ;2
19.23Single8HCXEndothelin-18HCX-ETB-Endothelin-1-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
19.23Single8IODPG-9018IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
19.23Consensusc5a1_onOrthosteric Ligand7Y65-C5a1-C5a peptide-Gi1/&β;1/&γ;2 8HK5-C5a1-Complement C5-Gi1/&β;1/&γ;2 7Y66-C5a1-BM213-Gi1/&β;1/&γ;2 7Y67-C5a1-C089 peptide-Gi1/&β;1/&γ;2 7Y64-C5a1-C5a anaphylatoxin-Gi1/&β;1/&γ;2
19.23Consensusmc1_onOrthosteric Ligand7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/&β;1/&γ;2 7F4D-MC1-Alpha-MSH-chim(NtGi1-Gs)/&β;1/&γ;2 7F4I-MC1-SHU9119-chim(NtGi1-Gs)/&β;1/&γ;2
19.05Single6K1QIRL25006K1Q-ETB-IRL2500
19.05Single7EZHCholecystokinin-87EZH-CCKA-Cholecystokinin-8-Gi1/&β;1/&γ;2
19.05Single7EZMCholecystokinin-87EZM-CCKA-Cholecystokinin-8-chim(NtGsL-Gq)/&β;1/&γ;2
19.05Single7LLLExendin-47LLL-GLP-1-Exendin-4-Gs/&β;1/&γ;2
19.05Single7YU8ONO-07405567YU8-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
19.05Single8GUTLEI-1028GUT-CB2-LEI-102-Gi1/&β;1/&γ;2
19.05Single8IQ6Latanoprost8IQ6-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
19.05Single8WRZ8D08WRZ-CB1-8D0-Arrestin1
19.05Single8XJOU466198XJO-TP-U46619-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
19.05Consensuscckb_onOrthosteric Ligand7XOW-CCKB-Gastrin-Gq/&β;1/&γ;2 7F8W-CCKB-Gastrin-17-chim(NtGsL-Gq)/&β;1/&γ;2 8IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/&β;1/&γ;2
19.05Consensusep4_onOrthosteric Ligand7D7M-EP4-Dinoprostone-Gs/&β;1/&γ;1 8GCP-EP4-PGE2-Gi1/&β;1/&γ;2 8GD9-EP4-Rivenprost-Gs/&β;1/&γ;2 8GDA-EP4-L902688-Gs/&β;1/&γ;2
19.05Consensusgs_cckOrthosteric Ligand7MBX-CCKA-Cholecystokinin-8-Gs/&β;1/&γ;1 7XOV-CCKA-SR146131-Gs/&β;1/&γ;2
19.05Consensusgs_lipidOrthosteric Ligandgs_ffa gs_prostanoid
19.05Consensusgs_prostanoidOrthosteric Ligand8IUK-FP-alpha-PGF2-alpha-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7CX2-EP2-PGE2-Gs/&β;1/&γ;2 7CX3-EP2-Taprenepag-Gs/&β;1/&γ;2 7D7M-EP4-Dinoprostone-Gs/&β;1/&γ;1 7CX4-EP2-Evatanepag-Gs/&β;1/&γ;2 8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
19.05Consensusot_onOrthosteric Ligand7QVM-OT-Oxytocin-chim(NtGi1-Go-CtGq)/&β;1/&γ;2
18.75Single3PWHZM2413853PWH-A2A-ZM241385
18.75Single3VG9ZM2413853VG9-A2A-ZM241385-Antibody
18.75Single6TQ6PubChem 1457142836TQ6-OX1-PubChem 145714283
18.75Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
18.75Single7W0MPubChem 1227019087W0M-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
18.75Single7W0OElabela7W0O-Apelin-Elabela-Gi1/&β;1/&γ;2
18.75Single7WF7S1P7WF7-S1P1-S1P-Gi1/&β;1/&γ;2
18.75Single7X9ANeuropeptide Y7X9A-Y1-Neuropeptide Y-Gi1/&β;1/&γ;2
18.75Single8J20Valeric acid8J20-FFA3-Valeric acid-AR420626-Gi1/&β;1/&γ;2
18.75Single8SZGCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-chim(NtGi1-Gq)/&β;1/&γ;2
18.75Single8T3SButyric acid8T3S-FFA2-Butyric acid-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
18.75Consensusffa3_on_alloOrthosteric Ligand8J20-FFA3-Valeric acid-AR420626-Gi1/&β;1/&γ;2
18.75Consensusmglu_onOther Ligandmglu2_on mglu4_on
18.52Single6P9YPACAP6P9Y-PAC1-PACAP-Gs/&β;1/&γ;2
18.52Single7VABNon-Acylated Tirzepatide7VAB-GIP-Non-Acylated Tirzepatide-chim(NtGi1-Gs)/&β;1/&γ;2
18.52Single7W57Neuromedin-S7W57-NMUR2-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
18.52Single7XV3Lysophosphatidylserine7XV3-GPR174-Lysophosphatidylserine-chim(NtGi1-Gs)/&β;1/&γ;2
18.52Single8E3XPACAP278E3X-PAC1-PACAP27-Gs/&β;1/&γ;2
18.52Consensusclass-d_onOrthosteric Ligandste2_on
18.52Consensusgi_compl-peptideOrthosteric Ligand8HK5-C5a1-Complement C5-Gi1/&β;1/&γ;2 8IA8-C3aB-E7 peptide-Gi1/&β;1/&γ;2 7Y66-C5a1-BM213-Gi1/&β;1/&γ;2 7Y67-C5a1-C089 peptide-Gi1/&β;1/&γ;2 8HK2-C3aB-C3a anaphylatoxin-Gi1/&β;1/&γ;2 7Y64-C5a1-C5a anaphylatoxin-Gi1/&β;1/&γ;2 7Y65-C5a1-C5a peptide-Gi1/&β;1/&γ;2
18.52Consensusgi_neuromedinOrthosteric Ligand7XK8-NMUR2-Neuromedin-U-25-Gi1/&β;1/&γ;2
18.52Consensusnpy2_onOrthosteric Ligand7YOO-Y2-Neuropeptide Y-Gi1/&β;1/&γ;2 7YON-Y2-Peptide YY(3-36)-Gi1/&β;1/&γ;2
18.18Single6OMMWKYMVX6OMM-FPR2-ALX-WKYMVX-Gi1/&β;1/&γ;2
18.18Single7RKFFractalkine7RKF-US28-Fractalkine-GDP-chim(NtGi1-G11)/&β;1/&γ;2
18.18Single7Y1FDynorphin7Y1F-κ-Dynorphin-Gi1/&β;1/&γ;2
18.18Single8IQ4Carboprost8IQ4-FP-alpha-Carboprost-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
18.18Consensusclass-d_offOrthosteric Ligandste2_off
18.18Consensusgo_compl-peptideOrthosteric Ligand8I95-C3aB-EP54-Go/&β;1/&γ;2 8IA2-C5a1-C5a anaphylatoxin-Go/&β;1/&γ;2 8I9L-C3aB-C3a anaphylatoxin-Go/&β;1/&γ;2 8J6D-C3aB-EP141-Go/&β;1/&γ;2
18.18Consensusgo_vasopressinOrthosteric Ligand7QVM-OT-Oxytocin-chim(NtGi1-Go-CtGq)/&β;1/&γ;2
18.18Consensusgq_cckOrthosteric Ligand8IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/&β;1/&γ;2 7F8W-CCKB-Gastrin-17-chim(NtGsL-Gq)/&β;1/&γ;2 7EZM-CCKA-Cholecystokinin-8-chim(NtGsL-Gq)/&β;1/&γ;2 7XOW-CCKB-Gastrin-Gq/&β;1/&γ;2
18.18Consensusgs_bombesinOrthosteric Ligand8H0Q-BB2-Gastrin Releasing Peptide-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8H0P-BB1-NMB30-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
18.18Consensuspth_onOrthosteric Ligandpth1_on pth2_on
18.18Consensusste2_offOrthosteric Ligand7QA8-STE2-Peptide
17.86Single6P9XCorticoliberin6P9X-CRF1-Corticoliberin-Gs/&β;1/&γ;2
17.86Single6VCBGLP-16VCB-GLP-1-GLP-1-LSN3160440-Gs/&β;1/&γ;2
17.86Single7AD3Alpha-factor mating pheromone7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
17.86Single7F53Alpha-MSH7F53-MC4-Alpha-MSH-Gs/&β;1/&γ;2
17.86Single7XK8Neuromedin-U-257XK8-NMUR2-Neuromedin-U-25-Gi1/&β;1/&γ;2
17.86Single7YOONeuropeptide Y7YOO-Y2-Neuropeptide Y-Gi1/&β;1/&γ;2
17.86Consensusetb_onOrthosteric Ligand8HCX-ETB-Endothelin-1-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8HBD-ETB-IRL1620-Gi1/&β;1/&γ;2
17.86Consensusgi_class-dOrthosteric Ligandgi_ste
17.86Consensusgi_proteinOrthosteric Ligandgi_chemokine gi_chemerin
17.86Consensusgi_steOrthosteric Ligand7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
17.86Consensusgs_cgrpOrthosteric Ligand6E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/&β;1/&γ;2; RAMP1 6UUN-CT Like (AM1)-Adrenomedullin-Gs/&β;1/&γ;2; RAMP2
17.65Single5UVIZM2413855UVI-A2A-ZM241385
17.65Single6FFIMMPEP6FFI-mGlu5-MMPEP
17.65Single6MH8ZM2413856MH8-A2A-ZM241385
17.65Single6PELCitronellol6PEL-Rhodopsin-Citronellol-Gt(CT)
17.65Single6PT0WIN 55212-26PT0-CB2-WIN 55212-2-Gi1/&β;1/&γ;2
17.65Single6TPKRetosiban6TPK-OT-Retosiban
17.65Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
17.65Single8DWGML3828DWG-MRGPRX1-Proenkephalin-A-ML382-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
17.65Single8GCML9026888GCM-EP4-L902688-Gi1/&β;1/&γ;2
17.65Single8H4LDoconexent8H4L-FFA4-Doconexent-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
17.65Single8HQN9(S)-HODE8HQN-GPR132-9(S)-HODE-Gi1/&β;1/&γ;2
17.65Consensuscb1_offOrthosteric Ligand5TGZ-CB1-AM6538 5U09-CB1-Taranabant
17.65Consensusffa2_onOrthosteric Ligand8J24-FFA2-Acetic acid-Gi1/&β;1/&γ;2 8T3S-FFA2-Butyric acid-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8J22-FFA2-TUG-1375-Gi1/&β;1/&γ;2
17.65Consensusghrelin_offOrthosteric Ligand6KO5-Ghrelin-PubChem 57400002 7F83-Ghrelin-PF-05190457
17.65Consensusot_offOrthosteric Ligand6TPK-OT-Retosiban
17.65Consensusvasopressin-ot_offOrthosteric Ligandot_off
17.39Single4XT1Fractalkine4XT1-US28-Fractalkine
17.39Single6WIVPubChem 52923113; PubChem 529246456WIV-GABAB1, GABAB2-PubChem 52923113; PubChem 52924645
17.39Single7TD4Siponimod7TD4-S1P1-Siponimod-Gi1/&β;1/&γ;2
17.39Single7XMRSomatostatin-147XMR-SST2-Somatostatin-14-Gi1/&β;1/&γ;2
17.39Consensusgi_ghrelinOrthosteric Ligand7NA7-Ghrelin-Ghrelin-27-Gi1/&β;1/&γ;2 7NA8-Ghrelin-PubChem 178024-Gi1/&β;1/&γ;2
17.39Consensusnmur1_onOrthosteric Ligand7W56-NMUR1-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
17.39Consensusste2_offOrthosteric Ligand7QA8-STE2-Peptide
17.24Single6LMLGlucagon6LML-Glucagon-Glucagon
17.24Single6WZGSecretin6WZG-Secretin-Secretin-Gs/&β;1/&γ;2
17.24Single7D68GLP-27D68-GLP-2-GLP-2-Gs/&β;1/&γ;2
17.24Single7KI1Taspoglutide7KI1-GLP-1-Taspoglutide-Gs/&β;1/&γ;2
17.24Consensuscrf_onOrthosteric Ligandcrf2_on crf1_on
17.14Single7F16TIP397F16-PTH2-TIP39-Gs/&β;1/&γ;2
17.14Consensusgs_pthOrthosteric Ligand8FLQ-PTH1-PTH-Gs/&β;1/&γ;2 7Y35-PTH1-Abaloparatide-Gs/&β;1/&γ;2 7Y36-PTH1-Teriparatide-Gs/&β;1/&γ;2 7F16-PTH2-TIP39-Gs/&β;1/&γ;2 7VVM-PTH1-PTH-Gs/&β;1/&γ;2 8FLU-PTH1-Long-acting PTH-Gs/&β;1/&γ;2 6NBF-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2
16.67Single5NDDAZ8838; Na5NDD-PAR2-AZ8838; Na
16.67Single5VAIGLP-15VAI-GLP-1-GLP-1-Gs/&β;1/&γ;2
16.67Single6FFHFenobam6FFH-mGlu5-Fenobam
16.67Single6IIVDaltroban6IIV-TP-Daltroban
16.67Single7C6A(Sar1,Ile8)-Angiotensin II7C6A-AT2-(Sar1,Ile8)-Angiotensin II
16.67Single7DUQGLP-17DUQ-GLP-1-GLP-1-PubChem 156022738-Gs/&β;1/&γ;2
16.67Single7E9GJNJ-404118137E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/&β;1/&γ;2
16.67Single7PIUSetmelanotide7PIU-MC4-Setmelanotide-Gs/&β;1/&γ;2
16.67Single7PP1Selatogrel7PP1-P2Y12-Selatogrel
16.67Single7VBINon-Acylated Tirzepatide7VBI-GLP-1-Non-Acylated Tirzepatide-Gs/&β;1/&γ;2
16.67Single7W56Neuromedin-S7W56-NMUR1-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
16.67Single7XBXCX3CL17XBX-CX3CR1-CX3CL1-Gi1/&β;1/&γ;2
16.67Single7YU4ONO-07405567YU4-LPA1-ONO-0740556
16.67Single8F7QBeta-endorphin8F7Q-μ-Beta-endorphin-Gi1/&β;1/&γ;2
16.67Single8KFYZK-7563268KFY-CCR8-ZK-756326-Gi1/&β;1/&γ;2
16.67Single8XJLPGF2-alpha8XJL-FP-alpha-PGF2-alpha-chim(NtGi2-Gs-CtGq)/&β;1/&γ;2
16.67Consensuscck_offOrthosteric Ligandccka_off
16.67Consensusccka_offOrthosteric Ligand7F8Y-CCKA-Devazepide 7F8U-CCKA-Lintitript
16.67Consensuscx3cr_onOrthosteric Ligandcx3cr1_on
16.67Consensusffa_onOrthosteric Ligandffa4_on ffa1_on ffa2_on ffa3_on
16.67Consensusfsh_on_alloOther Ligand8I2G-FSH-Glycoprotein hormones alpha chain-Compound 716340-Gs/&β;1/&γ;2
16.67Consensusgs_crfOrthosteric Ligand6P9X-CRF1-Corticoliberin-Gs/&β;1/&γ;2
16.67Consensushcar_offOrthosteric Ligandsuccinate_off
16.67Consensuslipid_offOrthosteric Ligandcannabinoid_off leuko_off lpl_off paf_off prostanoid_off
16.67Consensusp2y12_offOrthosteric Ligand4NTJ-P2Y12-AZD1283 7PP1-P2Y12-Selatogrel
16.67Consensuspaf_offOrthosteric Ligand5ZKQ-PAF-ABT-491 5ZKP-PAF-Foropafant (SR27417)
16.67Consensusprostanoid_offOrthosteric Ligandep_off tp_off dp_off
16.67Consensussuccinate_offOrthosteric Ligand6RNK-Succinate-NF-56-EJ40 6Z10-Succinate-PubChem 154585554
16.67Consensustp_offOrthosteric Ligand6IIV-TP-Daltroban 6IIU-TP-Ramatroban
16.67Consensusvasopressin-ot_onOrthosteric Ligandot_on v2_on
16.13Single6WPWGlucagon derivative ZP37806WPW-Glucagon-Glucagon derivative ZP3780-Gs/&β;1/&γ;2
16.13Single8FLSAbaloparatide8FLS-PTH1-Abaloparatide-Gs/&β;1/&γ;2
16.13Single8FLULong-acting PTH8FLU-PTH1-Long-acting PTH-Gs/&β;1/&γ;2
16.13Single8HBDIRL16208HBD-ETB-IRL1620-Gi1/&β;1/&γ;2
16.13Consensusglp_onOrthosteric Ligandglp1_on glp2_on
16.13Consensusmelanocortin_onOrthosteric Ligandmc2_on mc1_on mc3_on mc4_on mc5_on
16.00Single3OE0CVX153OE0-CXCR4-CVX15
16.00Single6W25SHU91196W25-MC4-SHU9119-Ca
16.00Single7F4HAfamelanotide7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/&β;1/&γ;2
16.00Consensuscx3cr1_onOrthosteric Ligand7XBX-CX3CR1-CX3CL1-Gi1/&β;1/&γ;2
16.00Consensusmc5_onOrthosteric Ligand8INR-MC5-Alpha-MSH-Ca-chim(NtGi1-Gs)/&β;1/&γ;2 8IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
15.79Single4NTJAZD12834NTJ-P2Y12-AZD1283
15.79Single5T1APubChem 68764898; PubChem 120931705T1A-CCR2-PubChem 68764898; PubChem 12093170
15.79Single5YHLPubChem 1351213525YHL-EP4-PubChem 135121352
15.79Single5YWYONO-AE3-2085YWY-EP4-ONO-AE3-208
15.79Single6M9TMisoprostol-FA6M9T-EP3-Misoprostol-FA
15.79Single6N4BMDMB-Fubinaca6N4B-CB1-MDMB-Fubinaca-Gi1/&β;1/&γ;2
15.79Single6RZ4Pranlukast6RZ4-CysLT1-Pranlukast-Na
15.79Single6RZ5Zafirlukast6RZ5-CysLT1-Zafirlukast-Na
15.79Single6XBKCholesterol6XBK-SMO-Cholesterol-Gi1/&β;1/&γ;2
15.79Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
15.79Single7T9NPubChem 6440787T9N-TSH-M22 Fab-PubChem 644078-Gs/&β;1/&γ;2
15.79Single7Y26Octreotide7Y26-SST2-Octreotide-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
15.79Single7Y27Somatostatin-147Y27-SST2-Somatostatin-14-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
15.79Single7YU3ONO-07405567YU3-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
15.79Single7YU6ONO-07405567YU6-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
15.79Single7YU7ONO-07405567YU7-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
15.79Single7YXAONO-54306087YXA-S1P5-ONO-5430608
15.79Single8GDAL9026888GDA-EP4-L902688-Gs/&β;1/&γ;2
15.79Single8GDCPGE28GDC-EP3-PGE2-Gi1/&β;1/&γ;2
15.79Consensusccr2_off_alloOther Ligand5T1A-CCR2-PubChem 68764898; PubChem 12093170 6GPX-CCR2-MK0812
15.79Consensusep3_onOrthosteric Ligand8GDC-EP3-PGE2-Gi1/&β;1/&γ;2
15.79Consensusep4_offOrthosteric Ligand5YWY-EP4-ONO-AE3-208 5YHL-EP4-PubChem 135121352
15.79Consensusep_offOrthosteric Ligandep4_off
15.79Consensusgs_class-b1Orthosteric Ligandgs_glucagon gs_vip-pacap gs_pth gs_calcitonin gs_crf
15.79Consensusgs_sstOrthosteric Ligand7Y27-SST2-Somatostatin-14-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
15.62Single7VVMPTH7VVM-PTH1-PTH-Gs/&β;1/&γ;2
15.62Consensuspth1_onOrthosteric Ligand8FLQ-PTH1-PTH-Gs/&β;1/&γ;2 8FLR-PTH1-PTHrP(1-36)-Gs/&β;1/&γ;2 7Y36-PTH1-Teriparatide-Gs/&β;1/&γ;2 7Y35-PTH1-Abaloparatide-Gs/&β;1/&γ;2 8FLU-PTH1-Long-acting PTH-Gs/&β;1/&γ;2 6NBF-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2 7VVM-PTH1-PTH-Gs/&β;1/&γ;2
15.62Consensusvip-pacap_onOrthosteric Ligandvpac1_on vpac2_on pca1_on
15.38Single6M1IPACAP6M1I-PAC1-PACAP-Gs/&β;1/&γ;2
15.38Single7XKEBetahydroxyandrosterone7XKE-ADGRG2-Betahydroxyandrosterone-chim(NtGi1-Gs)/&β;1/&γ;2
15.38Single7YONPeptide YY(3-36)7YON-Y2-Peptide YY(3-36)-Gi1/&β;1/&γ;2
15.38Single8HA0PTH8HA0-PTH1-PTH-chim(NtGi1-Gs)/&β;1/&γ;2
15.38Single8IA2C5a anaphylatoxin8IA2-C5a1-C5a anaphylatoxin-Go/&β;1/&γ;2
15.38Consensuscompl-peptide_onOrthosteric Ligandc5a1_on c3a_on
15.38Consensusgo_class-bOrthosteric Ligandgo_class-b1 go_class-b2
15.38Consensuspca1_onOrthosteric Ligand6M1I-PAC1-PACAP-Gs/&β;1/&γ;2
15.15Single7Y36Teriparatide7Y36-PTH1-Teriparatide-Gs/&β;1/&γ;2
15.15Single8FLQPTH8FLQ-PTH1-PTH-Gs/&β;1/&γ;2
15.15Consensusgs_vip-pacapOrthosteric Ligand8E3Y-VPAC1-PACAP27-Gs/&β;1/&γ;2 7VQX-VPAC1-PACAP27-Gs/&β;1/&γ;2 8E3Z-VPAC1-VIP-Gs/&β;1/&γ;2 6M1I-PAC1-PACAP-Gs/&β;1/&γ;2 6VN7-VPAC1-PACAP-Gs/&β;1/&γ;2
15.15Consensusmc2_onOrthosteric Ligand8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/&β;1/&γ;2; MRAP1
15.15Consensuspth2_onOrthosteric Ligand7F16-PTH2-TIP39-Gs/&β;1/&γ;2
15.00Single5ZBHBMS-1938855ZBH-Y1-BMS-193885
15.00Single6W2XPubChem 237279706W2X-GABAB1, GABAB2-PubChem 5311042-PubChem 23727970
15.00Single7F58THIQ7F58-MC4-THIQ-Gs/&β;1/&γ;2
15.00Single7FEEPubMed 1048957FEE-CB1-PubMed 104895-ZCZ011
15.00Single7P2L4YI7P2L-mGlu5-4YI
15.00Single7R0CAcyclovir triphosphate7R0C-V2-Acyclovir triphosphate-Arrestin2
15.00Single7XOWGastrin7XOW-CCKB-Gastrin-Gq/&β;1/&γ;2
15.00Single7XOXCholecystokinin-87XOX-CCKB-Cholecystokinin-8-Gq/&β;1/&γ;2
15.00Single7YU5ONO-07405567YU5-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
15.00Single8GDBPGE28GDB-EP4-PGE2-Gs/&β;1/&γ;2
15.00Single8I2GCompound 7163408I2G-FSH-Glycoprotein hormones alpha chain-Compound 716340-Gs/&β;1/&γ;2
15.00Single8JD5BQI; HZE; PEF8JD5-mGlu2; mGlu4-Glutamate-BQI; HZE; PEF-Gi1/&β;1/&γ;2
15.00Single8T6JCDPPB8T6J-mGlu5; mGlu5-CDPPB
15.00Single8TAOCDPPB8TAO-mGlu5; mGlu5-Quisqualate-CDPPB
14.81Single6X18GLP-16X18-GLP-1-GLP-1-Gs/&β;1/&γ;2
14.81Single7LLYOxyntomodulin7LLY-GLP-1-Oxyntomodulin-Gs/&β;1/&γ;2
14.81Single7TRYUrocortin7TRY-CRF2-Urocortin-chim(NtGi1-G11)/&β;1/&γ;2
14.81Single8HCQEndothelin-18HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
14.81Single8HK5Complement C58HK5-C5a1-Complement C5-Gi1/&β;1/&γ;2
14.81Single8KH5Lysophosphatidylserine8KH5-GPR174-Lysophosphatidylserine-Gs/&β;1/&γ;2
14.81Consensuscrf2_onOrthosteric Ligand7TS0-CRF2-Urocortin-chim(NtGi1L-Go)/&β;1/&γ;2
14.81Consensuseta_onOrthosteric Ligand8HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
14.81Consensusvpac1_onOrthosteric Ligand8E3Y-VPAC1-PACAP27-Gs/&β;1/&γ;2 8E3Z-VPAC1-VIP-Gs/&β;1/&γ;2 6VN7-VPAC1-PACAP-Gs/&β;1/&γ;2
14.71Single6E3YCalcitonin gene-related peptide-16E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/&β;1/&γ;2; RAMP1
14.29Single4XT3Fractalkine4XT3-US28-Fractalkine
14.29Single5X33BIIL2605X33-BLT1-BIIL260
14.29Single6AK3Dinoprostone IPGE26AK3-EP3-Dinoprostone IPGE2
14.29Single6C1RPMX536C1R-C5a1-PMX53-Avacopan; Na
14.29Single6FJ3PTH6FJ3-PTH1-PTH
14.29Single6IIURamatroban6IIU-TP-Ramatroban
14.29Single6KPGAM8416KPG-CB1-AM841-Gi1/&β;1/&γ;2
14.29Single6KQIPubMed 1048956KQI-CB1-PubMed 104895-ORG27569
14.29Single6NBFLong-acting PTH analog6NBF-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2
14.29Single6OT025(S)-Epoxycholesterol6OT0-SMO-25(S)-Epoxycholesterol-Gi1/&β;1/&γ;2
14.29Single6W2YPubChem 237279706W2Y-GABAB1; GABAB1-PubChem 5311042-PubChem 23727970
14.29Single7CZ5Somatoliberin7CZ5-GHRH-Somatoliberin-Gs/&β;1/&γ;2
14.29Single7D3SSecretin7D3S-Secretin-Secretin-Gs/&β;1/&γ;2
14.29Single7FIYTirzepatide7FIY-GIP-Tirzepatide-Gs/&β;1/&γ;2
14.29Single7KI0Semaglutide7KI0-GLP-1-Semaglutide-Gs/&β;1/&γ;2
14.29Single7RA3GIP7RA3-GIP-GIP-chim(NtGi1-Gs)/&β;1/&γ;2
14.29Single7W0NElabela7W0N-Apelin-Elabela-Gi1/&β;1/&γ;2
14.29Single7W3ZGastrin Releasing Peptide7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/&β;1/&γ;2
14.29Single7XW5ML1097XW5-TSH-TSH-ML109-Gs/&β;1/&γ;2
14.29Single7XW6ML1097XW6-TSH-M22 Fab-ML109-Gs/&β;1/&γ;2
14.29Single7Y66BM2137Y66-C5a1-BM213-Gi1/&β;1/&γ;2
14.29Single8H0QGastrin Releasing Peptide8H0Q-BB2-Gastrin Releasing Peptide-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
14.29Single8HK2C3a anaphylatoxin8HK2-C3aB-C3a anaphylatoxin-Gi1/&β;1/&γ;2
14.29Single8JISPeptide-158JIS-GLP-1-Peptide-15-chim(NtGi1-Gs)/&β;1/&γ;2
14.29Single8T6JCDPPB8T6J-mGlu5; mGlu5-CDPPB
14.29Consensusadgrg_onOrthosteric Ligandadgrg2_on adgrg3_on
14.29Consensuscb1_off_alloOrthosteric Ligand6KQI-CB1-PubMed 104895-ORG27569
14.29Consensusclass-b2_onOrthosteric Ligandadgrg_on
14.29Consensusep_onOrthosteric Ligandep4_on ep2_on ep3_on
14.29Consensusglp1_on_alloOrthosteric Ligand6VCB-GLP-1-GLP-1-LSN3160440-Gs/&β;1/&γ;2
14.29Consensustsh_on_alloOther Ligand7XW5-TSH-TSH-ML109-Gs/&β;1/&γ;2
13.79Single6UVAAdrenomedullin-26UVA-CT Like (AM2)-Adrenomedullin-2-Gs/&β;1/&γ;2; RAMP3
13.79Single7DTYGIP7DTY-GIP-GIP-Gs/&β;1/&γ;2
13.79Single7S1MEx4-D-Ala7S1M-GLP-1-Ex4-D-Ala-Gs/&β;1/&γ;2
13.79Single7VVJPTHrP(1-36)7VVJ-PTH1-PTHrP(1-36)-Gs/&β;1/&γ;2
13.79Single8FU6Glucagon derivative ZP37808FU6-Glucagon-Glucagon derivative ZP3780-Gs/&β;1/&γ;2
13.79Consensusccr8_onOrthosteric Ligand8U1U-CCR8-CCL1-Gi1/&β;1/&γ;2
13.79Consensusste2_onOrthosteric Ligand7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
13.64Single5TZYMK8666; PubChem 1270535975TZY-FFA1 (GPR40)-MK8666; PubChem 127053597
13.64Single7QVMOxytocin7QVM-OT-Oxytocin-chim(NtGi1-Go-CtGq)/&β;1/&γ;2
13.64Single7X8RBOC57X8R-GLP-1-BOC5-Gs/&β;1/&γ;2
13.64Single8HN1Toxin AdTx18HN1-Alpha1A-Toxin AdTx1
13.64Consensusadgrg2_onOrthosteric Ligand7XKD-ADGRG2-Betahydroxyandrosterone-Gs/&β;1/&γ;2 7WUI-ADGRG2-IP15-chim(NtGi1-Gs)/&β;1/&γ;2
13.64Consensusc5a1_off_ortoalloOrthosteric Ligand6C1Q-C5a1-PMX53-NDT9513727 6C1R-C5a1-PMX53-Avacopan; Na
13.64Consensusnk2_onOrthosteric Ligand7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
13.51Consensusclass-b1_onOrthosteric Ligandglucagon_on calcitonin_on vip-pacap_on pth_on crf_on
13.33Single2ZIY11-cis-Retinal2ZIY-Rhodopsin-11-cis-Retinal
13.33Single3OE6IT1t3OE6-CXCR4-IT1t
13.33Single3OE8IT1t3OE8-CXCR4-IT1t
13.33Single6FK9PubChem 1324730366FK9-Rhodopsin-PubChem 132473036
13.33Single6NBHLong-acting PTH analog6NBH-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2
13.33Single6PB1Urocortin6PB1-CRF2-Urocortin-chim(NtGi1-Gs)/&β;1/&γ;2
13.33Single6UUSAdrenomedullin6UUS-CT Like (AM2)-Adrenomedullin-Gs/&β;1/&γ;2; RAMP3
13.33Single8FLTM-PTH(1-14)8FLT-PTH1-M-PTH(1-14)-Gs/&β;1/&γ;2
13.33Single8HAFPTHrP(1-36)8HAF-PTH1-PTHrP(1-36)-chim(NtGi1-Gs)/&β;1/&γ;2
13.33Single8IY6Endothelin-18IY6-ETB-Endothelin-1
13.33Consensusgi_chemokineOrthosteric Ligand7VL9-CCR1-CCL15(26-92)-Gi1/&β;1/&γ;2 7XA3-CCR2-CCL2-Gi1/&β;1/&γ;2 7O7F-CCR5-(6P4)CCL5-Gi1/&β;1/&γ;1 7F1Q-CCR5-MIP-1a-Gi1/&β;1/&γ;2 7XBX-CX3CR1-CX3CL1-Gi1/&β;1/&γ;2 8IC0-CXCR1-Interleukin-8-Gi1/&β;1/&γ;2 6LFM-CXCR2-Interleukin-8-Gi1/&β;1/&γ;2 8U1U-CCR8-CCL1-Gi1/&β;1/&γ;2
13.33Consensussecretin_onOrthosteric Ligand6WZG-Secretin-Secretin-Gs/&β;1/&γ;2
13.16Consensusgs_calcitoninOrthosteric Ligandgs_ct gs_cgrp
13.04Single6C1QPMX536C1Q-C5a1-PMX53-NDT9513727
13.04Single7F9ZGHRP-67F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
13.04Single7NA7Ghrelin-277NA7-Ghrelin-Ghrelin-27-Gi1/&β;1/&γ;2
13.04Single8JBFSenktide8JBF-NK3-Senktide-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
13.04Consensuschemokine_onOrthosteric Ligandcxcr_on cx3cr_on
13.04Consensusmc4_onOrthosteric Ligand7F53-MC4-Alpha-MSH-Gs/&β;1/&γ;2 7F55-MC4-Bremelanotide-Gs/&β;1/&γ;2 7PIV-MC4-Setmelanotide-Gs/&β;1/&γ;2 7F58-MC4-THIQ-Gs/&β;1/&γ;2 7F54-MC4-Afamelanotide-Gs/&β;1/&γ;2
13.04Consensusprotein_onOrthosteric Ligandccr_on chemokine_on gphr_on chemerin_on
12.82Single8GY7Corticotropin8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/&β;1/&γ;2; MRAP1
12.50Single5L7IVismodegib5L7I-SMO-Vismodegib
12.50Single5VBLApelin Mimetic Peptide Agonist5VBL-Apelin-Apelin Mimetic Peptide Agonist
12.50Single6FK6PubChem 1324730336FK6-Rhodopsin-PubChem 132473033
12.50Single6PH7Nerol6PH7-Rhodopsin-Nerol-Gt(CT)
12.50Single7D76Beclomethasone7D76-ADGRG3-Beclomethasone-Go/&β;1/&γ;2
12.50Single7F54Afamelanotide7F54-MC4-Afamelanotide-Gs/&β;1/&γ;2
12.50Single7W53Neuromedin-U-257W53-NMUR1-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
12.50Single7XP6Strychnine7XP6-T2R46-Strychnine-chim(Gs-CtGt3)/&β;1/&γ;2
12.50Single8H8JLodoxamide8H8J-GPR35-Lodoxamide-Ca-chim(NtGi1L-G13)/&β;1/&γ;2
12.50Single8IZBLysophosphatidylserine8IZB-GPR174-Lysophosphatidylserine-Gs/&β;1/&γ;2
12.50Single8U4OCXCL128U4O-CXCR4-CXCL12-Cholesterol-Gi1/&β;1/&γ;2
12.50Single8U4RREGN7663-Fab8U4R-CXCR4-REGN7663-Fab-Cholesterol
12.50Single8X2K5YM8X2K-GPR3-5YM-chim(NtGi1-Gs)/&β;1/&γ;2
12.50Single8XBHS3E-LysoPS8XBH-GPR34-S3E-LysoPS-Gi1/&β;1/&γ;2
12.50Consensusclass-t_onOrthosteric Ligandtaste2_on
12.50Consensusgo_adhesionOrthosteric Ligand7D77-ADGRG3-Hydrocortisone-Go/&β;1/&γ;2 7D76-ADGRG3-Beclomethasone-Go/&β;1/&γ;2
12.50Consensusgo_class-b2Orthosteric Ligandgo_adhesion
12.50Consensusgs_class-tOrthosteric Ligandgs_taste
12.50Consensusgs_tasteOrthosteric Ligand7XP6-T2R46-Strychnine-chim(Gs-CtGt3)/&β;1/&γ;2
12.50Consensusprotein_offOrthosteric Ligandccr_off chemokine_off gnrh_off
12.50Consensustaste2_onOrthosteric Ligand7XP6-T2R46-Strychnine-chim(Gs-CtGt3)/&β;1/&γ;2
12.12Single7V35Peptide-207V35-Glucagon-Peptide-20-Gs/&β;1/&γ;2
12.12Single8JIPMEDI03828JIP-GLP-1-MEDI0382-chim(NtGi1-Gs)/&β;1/&γ;2
12.12Single8U1UCCL18U1U-CCR8-CCL1-Gi1/&β;1/&γ;2
12.00Single6WHCGlu16 analog of GCG6WHC-Glucagon-Glu16 analog of GCG-Gs/&β;1/&γ;2
12.00Single7PIVSetmelanotide7PIV-MC4-Setmelanotide-Gs/&β;1/&γ;2
12.00Single7SK5CXCL127SK5-ACKR3-CXCL12
12.00Consensussst_offOrthosteric Ligandsst2_off
11.76Single3ODUIT1t3ODU-CXCR4-IT1t
11.76Single5U09Taranabant5U09-CB1-Taranabant
11.76Single5ZKQABT-4915ZKQ-PAF-ABT-491
11.76Single6FKBPubChem 1324730386FKB-Rhodopsin-PubChem 132473038
11.76Single6RNKNF-56-EJ406RNK-Succinate-NF-56-EJ40
11.76Single7BR3Elagolix7BR3-GnRH1-Elagolix
11.76Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
11.76Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
11.76Single8HMPPubChem 699214798HMP-GPR52-PubChem 69921479-Gs/&β;1/&γ;2
11.76Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
11.76Single8U4PAMD31008U4P-CXCR4-AMD3100-Cholesterol-Gi1/&β;1/&γ;2
11.76Single8U8FPML8U8F-GPR3-PML-Gs/&β;1/&γ;2
11.76Consensusgnrh1_offOrthosteric Ligand7BR3-GnRH1-Elagolix
11.76Consensusgs_glucagonOrthosteric Ligand6X18-GLP-1-GLP-1-Gs/&β;1/&γ;2 6B3J-GLP-1-Exendin-P5-Gs/&β;1/&γ;2 6WZG-Secretin-Secretin-Gs/&β;1/&γ;2 6X1A-GLP-1-Danuglipron-Gs/&β;1/&γ;2 7CZ5-GHRH-Somatoliberin-Gs/&β;1/&γ;2 7D68-GLP-2-GLP-2-Gs/&β;1/&γ;2 7DTY-GIP-GIP-Gs/&β;1/&γ;2 7FIM-GLP-1-Tirzepatide-Gs/&β;1/&γ;2 7FIN-GIP-Peptide-20; GGL-Gs/&β;1/&γ;2 7FIY-GIP-Tirzepatide-Gs/&β;1/&γ;2 7KI0-GLP-1-Semaglutide-Gs/&β;1/&γ;2 7RTB-GLP-1-Peptide-19-Gs/&β;1/&γ;2 7S1M-GLP-1-Ex4-D-Ala-Gs/&β;1/&γ;2 7VAB-GIP-Non-Acylated Tirzepatide-chim(NtGi1-Gs)/&β;1/&γ;2 8JIU-Glucagon-SAR425899-Gs/&β;1/&γ;2
11.54Single7F4DAlpha-MSH7F4D-MC1-Alpha-MSH-chim(NtGi1-Gs)/&β;1/&γ;2
11.54Single7O7F(6P4)CCL57O7F-CCR5-(6P4)CCL5-Gi1/&β;1/&γ;1
11.54Single7VVNPTH7VVN-PTH1-PTH-Gs/&β;1/&γ;2
11.54Single7XA3CCL27XA3-CCR2-CCL2-Gi1/&β;1/&γ;2
11.54Single7XNACYN1548067XNA-SST2-CYN154806
11.54Consensusccr2_onOrthosteric Ligand7XA3-CCR2-CCL2-Gi1/&β;1/&γ;2
11.54Consensusgo_peptideOrthosteric Ligandgo_opioid go_ghrelin go_compl-peptide go_galanin go_vasopressin
11.54Consensusmc3_onOrthosteric Ligand8IOC-MC3-Gamma-MSH-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
11.54Consensussst2_offOrthosteric Ligand7XNA-SST2-CYN154806
11.43Single8JIUSAR4258998JIU-Glucagon-SAR425899-Gs/&β;1/&γ;2
11.43Consensusgs_class-bOrthosteric Ligandgs_class-b1 gs_class-b2
11.11Single6FK8PubChem 1324730356FK8-Rhodopsin-PubChem 132473035
11.11Single6FKAPubChem 1324730376FKA-Rhodopsin-PubChem 132473037
11.11Single6MEOEnvelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd46MEO-CCR5-Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4
11.11Single6METEnvelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd46MET-CCR5-Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4
11.11Single7FINPeptide-20; GGL7FIN-GIP-Peptide-20; GGL-Gs/&β;1/&γ;2
11.11Single7VVOPTH7VVO-PTH1-PTH-Gs/&β;1/&γ;2
11.11Single7XOVSR1461317XOV-CCKA-SR146131-Gs/&β;1/&γ;2
11.11Single7XXH2MeSADP7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/&β;1/&γ;2
11.11Single8K2WAMG4878K2W-CXCR3-AMG487
11.11Single8K4NVF08K4N-GPR34-VF0-Gi1/&β;1/&γ;2
11.11Single8WC8ZH86518WC8-TA1-ZH8651-chim(NtGi1-Gs)/&β;1/&γ;2
11.11Single8X7ATreprostinil8X7A-I2-Treprostinil-Gs/&β;1/&γ;2
11.11Single8XZJWN3538XZJ-Apelin-WN353-Gi1/&β;1/&γ;2
11.11Consensusccr1_onOrthosteric Ligand7VL9-CCR1-CCL15(26-92)-Gi1/&β;1/&γ;2
11.11Consensusgnrh_offOrthosteric Ligandgnrh1_off
11.11Consensusnmur2_onOrthosteric Ligand7W57-NMUR2-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
11.11Consensusnmur_onOrthosteric Ligandnmur1_on nmur2_on
11.11Consensusste2_onOrthosteric Ligand7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
10.81Consensusglucagon_onOrthosteric Ligandgip_on glu_on secretin_on ghrh_on glp_on
10.71Single7F9YGhrelin-287F9Y-Ghrelin-Ghrelin-28-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
10.71Single7P02Protachykinin-17P02-NK1-Protachykinin-1-chim(NtGi1-Gs)/&β;1/&γ;2
10.71Single7VL9CCL15(26-92)7VL9-CCR1-CCL15(26-92)-Gi1/&β;1/&γ;2
10.71Single7Y35Abaloparatide7Y35-PTH1-Abaloparatide-Gs/&β;1/&γ;2
10.71Consensusgs_ghrelinOrthosteric Ligand7F9Y-Ghrelin-Ghrelin-28-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
10.71Consensusgs_melanocortinOrthosteric Ligand7F4D-MC1-Alpha-MSH-chim(NtGi1-Gs)/&β;1/&γ;2 7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/&β;1/&γ;2 7F54-MC4-Afamelanotide-Gs/&β;1/&γ;2 7F53-MC4-Alpha-MSH-Gs/&β;1/&γ;2 7F55-MC4-Bremelanotide-Gs/&β;1/&γ;2 7PIV-MC4-Setmelanotide-Gs/&β;1/&γ;2 7F4I-MC1-SHU9119-chim(NtGi1-Gs)/&β;1/&γ;2 7F58-MC4-THIQ-Gs/&β;1/&γ;2
10.71Consensusgs_neuromedinOrthosteric Ligand7W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7W56-NMUR1-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7W57-NMUR2-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
10.53Single6FK7PubChem 1324730346FK7-Rhodopsin-PubChem 132473034
10.53Single6FKCPubChem 1324730396FKC-Rhodopsin-PubChem 132473039
10.53Single6FKDPubChem 1373491836FKD-Rhodopsin-PubChem 137349183
10.53Single7F83PF-051904577F83-Ghrelin-PF-05190457
10.53Single7NA8PubChem 1780247NA8-Ghrelin-PubChem 178024-Gi1/&β;1/&γ;2
10.53Single8EJCTAK-8758EJC-FFA1 (GPR40)-TAK-875-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
10.53Single8EJKTAK-8758EJK-FFA1 (GPR40)-TAK-875-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
10.53Consensusffa1_onOrthosteric Ligand8EIT-FFA1 (GPR40)-Doconexent-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2 8EJC-FFA1 (GPR40)-TAK-875-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2 8T3V-FFA1-DHA-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
10.53Consensusglu_onOrthosteric Ligand6LMK-Glucagon-Glucagon-Gs/&β;1/&γ;2 6WPW-Glucagon-Glucagon derivative ZP3780-Gs/&β;1/&γ;2 8JIT-Glucagon-MEDI0382-Gs/&β;1/&γ;2 8JIQ-Glucagon-Peptide-15-Gs/&β;1/&γ;2 7V35-Glucagon-Peptide-20-Gs/&β;1/&γ;2 8JIU-Glucagon-SAR425899-Gs/&β;1/&γ;2 6WHC-Glucagon-Glu16 analog of GCG-Gs/&β;1/&γ;2
10.34Single5UIW5P7-CCL55UIW-CCR5-5P7-CCL5
10.34Single6NBILong-acting PTH analog6NBI-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2
10.34Single7SK4CXCL12_LRHQ7SK4-ACKR3-CXCL12_LRHQ
10.34Single8FLRPTHrP(1-36)8FLR-PTH1-PTHrP(1-36)-Gs/&β;1/&γ;2
10.34Single8HAOPTH8HAO-PTH1-PTH-chim(NtGi1-Gs)/&β;1/&γ;2
10.34Consensusccr5_offOrthosteric Ligand5UIW-CCR5-5P7-CCL5
10.34Consensusctlike_onOrthosteric Ligand6E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/&β;1/&γ;2; RAMP1 6UUN-CT Like (AM1)-Adrenomedullin-Gs/&β;1/&γ;2; RAMP2
10.34Consensusghrh_onOrthosteric Ligand7CZ5-GHRH-Somatoliberin-Gs/&β;1/&γ;2
10.00Single4PHUFasiglifam4PHU-FFA1 (GPR40)-Fasiglifam
10.00Single6LFMInterleukin-86LFM-CXCR2-Interleukin-8-Gi1/&β;1/&γ;2
10.00Single7VQXPACAP277VQX-VPAC1-PACAP27-Gs/&β;1/&γ;2
10.00Single8IZ4Lysophosphatidylserine8IZ4-GPR34-Lysophosphatidylserine-Gi1/&β;1/&γ;2
10.00Consensusccr_onOrthosteric Ligandccr5_on ccr6_on ccr1_on ccr2_on ccr8_on
10.00Consensusclass-c_offOther Ligandgabab_off mglu_off
10.00Consensusglp2_onOrthosteric Ligand7D68-GLP-2-GLP-2-Gs/&β;1/&γ;2
9.68Single7VVLPTH7VVL-PTH1-PTH-Gs/&β;1/&γ;2
9.68Consensusglp1_onOrthosteric Ligand6X18-GLP-1-GLP-1-Gs/&β;1/&γ;2 6X19-GLP-1-CHU-128-Gs/&β;1/&γ;2 6X1A-GLP-1-Danuglipron-Gs/&β;1/&γ;2 7S1M-GLP-1-Ex4-D-Ala-Gs/&β;1/&γ;2 7LLL-GLP-1-Exendin-4-Gs/&β;1/&γ;2 6B3J-GLP-1-Exendin-P5-Gs/&β;1/&γ;2 8JIP-GLP-1-MEDI0382-chim(NtGi1-Gs)/&β;1/&γ;2 7VBI-GLP-1-Non-Acylated Tirzepatide-Gs/&β;1/&γ;2 6XOX-GLP-1-Orforglipron-chim(NtGi1-Gs)/&β;1/&γ;2 8JIS-GLP-1-Peptide-15-chim(NtGi1-Gs)/&β;1/&γ;2 7RTB-GLP-1-Peptide-19-Gs/&β;1/&γ;2 7VBH-GLP-1-Peptide-20-Gs/&β;1/&γ;2 7C2E-GLP-1-PubChem 149050799-Gs/&β;1/&γ;2 8JIR-GLP-1-SAR425899-chim(NtGi1-Gs)/&β;1/&γ;2 7KI0-GLP-1-Semaglutide-Gs/&β;1/&γ;2 7KI1-GLP-1-Taspoglutide-Gs/&β;1/&γ;2 7FIM-GLP-1-Tirzepatide-Gs/&β;1/&γ;2
9.68Consensusvpac2_onOrthosteric Ligand7VQX-VPAC1-PACAP27-Gs/&β;1/&γ;2
9.52Single5TZR-5TZR-FFA1 (GPR40)-MK8666
9.52Single7AUESetmelanotide7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/&β;1/&γ;2
9.52Single7F1TMIP-1a7F1T-CCR5-MIP-1a
9.52Single7XWONeurokinin-A7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
9.52Single7Y67C089 peptide7Y67-C5a1-C089 peptide-Gi1/&β;1/&γ;2
9.52Single8HQCC5a anaphylatoxin8HQC-C5a1-C5a anaphylatoxin-Go/&β;1/&γ;2
9.52Single8XBIS3E-LysoPS8XBI-GPR34-S3E-LysoPS
9.52Consensusmglu2_onOther Ligand7MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/&β;1/&γ;2 7E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/&β;1/&γ;2
9.52Consensuss1p2_onOrthosteric Ligand7T6B-S1P2-S1P-chim(NtGi1L-G13)/&β;1/&γ;2
9.38Single7RBTTirzepatide7RBT-GIP-Tirzepatide-PubChem 163183774-chim(NtGi1-Gs)/&β;1/&γ;2
9.38Consensusgip_onOrthosteric Ligand7DTY-GIP-GIP-Gs/&β;1/&γ;2 7VAB-GIP-Non-Acylated Tirzepatide-chim(NtGi1-Gs)/&β;1/&γ;2 7FIN-GIP-Peptide-20; GGL-Gs/&β;1/&γ;2 7FIY-GIP-Tirzepatide-Gs/&β;1/&γ;2
9.38Consensusgip_on_alloOrthosteric Ligand7RBT-GIP-Tirzepatide-PubChem 163183774-chim(NtGi1-Gs)/&β;1/&γ;2
9.09Single4PY02MeSATP4PY0-P2Y12-2MeSATP
9.09Single6OS2TRV0266OS2-AT1-TRV026
9.09Single6RZ7ONO-25703666RZ7-CysLT2-ONO-2570366
9.09Single7D7MDinoprostone7D7M-EP4-Dinoprostone-Gs/&β;1/&γ;1
9.09Single7F55Bremelanotide7F55-MC4-Bremelanotide-Gs/&β;1/&γ;2
9.09Single7SK6CXCL12_LRHQ7SK6-ACKR3-CXCL12_LRHQ
9.09Single7T6BS1P7T6B-S1P2-S1P-chim(NtGi1L-G13)/&β;1/&γ;2
9.09Single7VBHPeptide-207VBH-GLP-1-Peptide-20-Gs/&β;1/&γ;2
9.09Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/&β;1/&γ;2
9.09Single8U26Protachykinin-18U26-NK1-Protachykinin-1-Gs/&β;1/&γ;2
9.09Single8WRBLysophosphatidylserine8WRB-GPR34-Lysophosphatidylserine-Gi1/&β;1/&γ;2
8.82Single8JIRSAR4258998JIR-GLP-1-SAR425899-chim(NtGi1-Gs)/&β;1/&γ;2
8.70Single4PXZ2MeSADP4PXZ-P2Y12-2MeSADP
8.70Single6RZ9ONO-27703726RZ9-CysLT2-ONO-2770372
8.70Single7CX2PGE27CX2-EP2-PGE2-Gs/&β;1/&γ;2
8.70Single7CX4Evatanepag7CX4-EP2-Evatanepag-Gs/&β;1/&γ;2
8.70Single7P00Substance P7P00-NK1-Substance P-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
8.70Consensuscyslt2_offOrthosteric Ligand6RZ6-CysLT2-ONO-2570366 6RZ9-CysLT2-ONO-2770372 6RZ8-CysLT2-ONO-2080365
8.70Consensuscyslt_offOrthosteric Ligandcyslt2_off
8.70Consensusep2_onOrthosteric Ligand7CX4-EP2-Evatanepag-Gs/&β;1/&γ;2 7CX2-EP2-PGE2-Gs/&β;1/&γ;2 7CX3-EP2-Taprenepag-Gs/&β;1/&γ;2
8.57Single8JITMEDI03828JIT-Glucagon-MEDI0382-Gs/&β;1/&γ;2
8.33Single6RZ6ONO-25703666RZ6-CysLT2-ONO-2570366
8.33Single7RKNFractalkine7RKN-US28-Fractalkine-Gi1/&β;1/&γ;2
8.33Single7RMGSubstance P7RMG-NK1-Substance P-chim(Gs-CtGq)/&β;1/&γ;2
8.33Single7W2ZGhrelin7W2Z-Ghrelin-Ghrelin-Go/&β;1/&γ;2
8.33Single7X8SWB4-247X8S-GLP-1-WB4-24-Gs/&β;1/&γ;2
8.33Single8INRAlpha-MSH8INR-MC5-Alpha-MSH-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
8.33Single8SAI1-oleoyl-2-hydroxy-sn-glycero-3-phospho-L-serine8SAI-GPR34-1-oleoyl-2-hydroxy-sn-glycero-3-phospho-L-serine-Gi1/&β;1/&γ;2
8.33Consensusgo_ghrelinOrthosteric Ligand7W2Z-Ghrelin-Ghrelin-Go/&β;1/&γ;2
8.33Consensusgs_adgrOrthosteric Ligand7XKD-ADGRG2-Betahydroxyandrosterone-Gs/&β;1/&γ;2 7WUI-ADGRG2-IP15-chim(NtGi1-Gs)/&β;1/&γ;2
8.33Consensusgs_class-b2Orthosteric Ligandgs_adgr
8.33Consensusnk1_onOrthosteric Ligand8U26-NK1-Protachykinin-1-Gs/&β;1/&γ;2 7P00-NK1-Substance P-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
8.00Single6RZ8ONO-20803656RZ8-CysLT2-ONO-2080365
8.00Single6X19CHU-1286X19-GLP-1-CHU-128-Gs/&β;1/&γ;2
8.00Single7CX3Taprenepag7CX3-EP2-Taprenepag-Gs/&β;1/&γ;2
8.00Single7RMHSubstance P7RMH-NK1-Substance P-Gs/&β;1/&γ;2
8.00Single8JIQPeptide-158JIQ-Glucagon-Peptide-15-Gs/&β;1/&γ;2
7.69Single7E14Orforglipron7E14-GLP-1-Orforglipron-PubChem 156022738-Gs/&β;1/&γ;2
7.69Single7F1QMIP-1a7F1Q-CCR5-MIP-1a-Gi1/&β;1/&γ;2
7.69Single7RMISubstance P7RMI-NK1-Substance P-chim(Gs-CtGq)/&β;1/&γ;2
7.69Single7SHEPI; PE7SHE-GPR158-PI; PE
7.69Single8IBVMotilin8IBV-Motilin-Motilin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
7.69Single8IOCGamma-MSH8IOC-MC3-Gamma-MSH-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
7.41Consensusccr_offOrthosteric Ligandccr5_off ccr8_off
7.41Consensusgs_motilinOrthosteric Ligand8IBV-Motilin-Motilin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IBU-Motilin-Erythromycin A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
7.41Consensusgs_tachykininOrthosteric Ligand8U26-NK1-Protachykinin-1-Gs/&β;1/&γ;2 7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7P00-NK1-Substance P-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
7.41Consensustachykinin_onOrthosteric Ligandnk1_on nk2_on
7.14Single5YQZGlucagon analogue5YQZ-Glucagon-Glucagon analogue
7.14Single6NIYAdrenomedullin6NIY-CT-Adrenomedullin-Gs/&β;1/&γ;2
7.14Single7V68PubChem 576644067V68-M4-Iperoxo-PubChem 57664406-Gi1/&β;1/&γ;2
7.14Single8HQMNPGLY8HQM-GPR132-NPGLY-Gi1/&β;1/&γ;2
7.14Single8SZICa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZI-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi3/&β;1/&γ;2
7.14Consensusclass-c_onOther Ligandgabab_on mglu_on
7.14Consensusghrelin_onOrthosteric Ligand7W2Z-Ghrelin-Ghrelin-Go/&β;1/&γ;2 7F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7NA8-Ghrelin-PubChem 178024-Gi1/&β;1/&γ;2
6.67Single7SK3CXCL127SK3-ACKR3-CXCL12
6.67Single7XKDBetahydroxyandrosterone7XKD-ADGRG2-Betahydroxyandrosterone-Gs/&β;1/&γ;2
6.67Single8HVINOX-6-78HVI-GPR132-NOX-6-7-Gi1/&β;1/&γ;2
6.67Consensusccr5_onOrthosteric Ligand7O7F-CCR5-(6P4)CCL5-Gi1/&β;1/&γ;1 7F1Q-CCR5-MIP-1a-Gi1/&β;1/&γ;2
6.45Single5NX2GLP-1 (Truncated)5NX2-GLP-1-GLP-1 (Truncated)
6.45Single6LMKGlucagon6LMK-Glucagon-Glucagon-Gs/&β;1/&γ;2
6.25Single6LI0GTPL98046LI0-GPR52-GTPL9804
6.25Single7D77Hydrocortisone7D77-ADGRG3-Hydrocortisone-Go/&β;1/&γ;2
6.25Single7V6APubChem 98642757V6A-M4-PubChem 9864275-Gi1/&β;1/&γ;2
6.25Single7VVKPTH7VVK-PTH1-PTH-Gs/&β;1/&γ;2
6.25Consensuscalcitonin_onOrthosteric Ligandct_on ctlike_on
6.25Consensusgip_on_alloOther Ligand7RBT-GIP-Tirzepatide-PubChem 163183774-chim(NtGi1-Gs)/&β;1/&γ;2
6.25Consensussmo_off_alloOrthosteric Ligand6D32-SMO-Cyclopamine-Cyclopamine
5.88Single4MQTLY21196204MQT-M2-Iperoxo-LY2119620
5.88Single6U1NLY21196206U1N-M2-LY2119620-Arrestin2
5.88Single7TRPLY20332987TRP-M4-Iperoxo-LY2033298-Gi1/&β;1/&γ;2
5.88Consensusm4_on_alloOther Ligand7TRP-M4-Iperoxo-LY2033298-Gi1/&β;1/&γ;2 7TRQ-M4-Iperoxo-VU0467154-Gi1/&β;1/&γ;2 7V68-M4-Iperoxo-PubChem 57664406-Gi1/&β;1/&γ;2
5.88Consensussmo_on_alloOrthosteric Ligand6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
5.56Single6PWCNeurotensin6PWC-NTS1-Neurotensin-Arrestin2
5.56Single7F8YDevazepide7F8Y-CCKA-Devazepide
5.56Single7LCJDanuglipron7LCJ-GLP-1-Danuglipron
5.56Single7T94PubChem 576644067T94-M2-Acetylcholine-PubChem 57664406-chim(NtGi1-Go)/&β;1/&γ;2
5.56Single7VDLCortistatin-147VDL-MRGPRX2-Cortistatin-14-Gi1/&β;1/&γ;2
5.56Single7X2CFenoldopam7X2C-D1-Fenoldopam-Fenoldopam-Gs/&β;1/&γ;2
5.56Consensuscxcr1_onOrthosteric Ligand8IC0-CXCR1-Interleukin-8-Gi1/&β;1/&γ;2
5.56Consensusm2_on_alloOther Ligand7T94-M2-Acetylcholine-PubChem 57664406-chim(NtGi1-Go)/&β;1/&γ;2 6OIK-M2-Iperoxo-LY2119620-chim(NtGi1-Go)/&β;1/&γ;2
5.56Consensusp2y_offOrthosteric Ligandp2y1_off p2y12_off
5.56Consensussmo_on_alloOther Ligand6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
5.26Single6WJCMuscarinic toxin 76WJC-M1-Atropine-Muscarinic toxin 7
5.26Single6ZA8RTI-3a6ZA8-NTS1-RTI-3a
5.26Single7C2EPubChem 1490507997C2E-GLP-1-PubChem 149050799-Gs/&β;1/&γ;2
5.26Single7S8PMS471347S8P-MRGPRX4-MS47134-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
5.26Single7TRQVU04671547TRQ-M4-Iperoxo-VU0467154-Gi1/&β;1/&γ;2
5.26Single7UTZPubChem 6440787UTZ-TSH-TR1402-PubChem 644078-Gs/&β;1/&γ;2
5.26Single8IYXYL-3658IYX-GPR34-YL-365
5.26Single8JD6N-(3-chlorophenyl)pyridine-2-carboxamide8JD6-mGlu4; mGlu4-Phosphoserine-N-(3-chlorophenyl)pyridine-2-carboxamide-Gi3/&β;1/&γ;2
5.26Single8T3VDHA8T3V-FFA1-DHA-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
5.26Consensusct_onOrthosteric Ligand7TYL-CT-Amylin-Gs/&β;1/&γ;2 7TYN-CT-Calcitonin-1-Gs/&β;1/&γ;2 8F0J-CT-Pramlintide analogue san45-Gs/&β;1/&γ;2 6NIY-CT-Adrenomedullin-Gs/&β;1/&γ;2
5.26Consensuscxcr2_onOrthosteric Ligand6LFM-CXCR2-Interleukin-8-Gi1/&β;1/&γ;2
5.26Consensuscxcr_onOrthosteric Ligandcxcr1_on cxcr2_on
5.26Consensuslh_on_alloOther Ligand7FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/&β;1/&γ;2
5.26Consensusm1_off_alloOther Ligand6WJC-M1-Atropine-Muscarinic toxin 7
5.00Single4QIMPubChem 249053754QIM-SMO-PubChem 24905375
5.00Single6X1ADanuglipron6X1A-GLP-1-Danuglipron-Gs/&β;1/&γ;2
5.00Single7FIHOrg435537FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/&β;1/&γ;2
5.00Single7LCIDanuglipron7LCI-GLP-1-Danuglipron-Gs/&β;1/&γ;2
5.00Single7LCKDanuglipron7LCK-GLP-1-Danuglipron
5.00Single8IC0Interleukin-88IC0-CXCR1-Interleukin-8-Gi1/&β;1/&γ;2
5.00Consensussmo_offOrthosteric Ligand5L7I-SMO-Vismodegib 4O9R-SMO-Cyclopamine 4QIM-SMO-PubChem 24905375 4JKV-SMO-Taladegib (LY2940680)
4.76Single4JKVTaladegib (LY2940680)4JKV-SMO-Taladegib (LY2940680)
4.76Single7VV0PAMP-127VV0-MRGPRX2-PAMP-12
4.76Single7VV4Cortistatin-147VV4-MRGPRX2-Cortistatin-14
4.76Single8FN1Neurotensin/neuromedin N8FN1-NTS1-Neurotensin/neuromedin N-chim(NtGi1-Go)/&β;1/&γ;2
4.76Single8JPCNeurotensin 8-138JPC-NTS1-Neurotensin 8-13-PubChem 118610427; GDP; Mg-Gq; GRK2
4.76Single8SZICa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZI-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi3/&β;1/&γ;2
4.55Single5V56TC1145V56-SMO-TC114
4.55Single5V57TC1145V57-SMO-TC114
4.55Single6OS1TRV0266OS1-AT1-TRV026
4.55Single6Z4QSR142948A6Z4Q-NTS1-SR142948A
4.55Single7S8MCortistatin-147S8M-MRGPRX2-Cortistatin-14-Gi1/&β;1/&γ;2
4.55Single7XBDGalanin7XBD-GAL2-Galanin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
4.55Single7XJLSpexin7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
4.55Single8JD5BQI; HZE; PEF8JD5-mGlu2; mGlu4-Glutamate-BQI; HZE; PEF-Gi1/&β;1/&γ;2
4.35Single3VW7Vorapaxar; Na3VW7-PAR1-Vorapaxar; Na
4.35Single4XEENeurotensin4XEE-NTS1-Neurotensin
4.35Single4XESNeurotensin4XES-NTS1-Neurotensin
4.35Single6XOXOrforglipron6XOX-GLP-1-Orforglipron-chim(NtGi1-Gs)/&β;1/&γ;2
4.35Single6YVRNTS8-136YVR-NTS1-NTS8-13
4.35Single7L0SNeurotensin7L0S-NTS1-Neurotensin-Gi1/&β;1/γ1
4.35Single7SHEPI; PE7SHE-GPR158-PI; PE
4.35Single7XXI2MeSADP7XXI-P2Y12-2MeSADP-Gi2/&β;1/&γ;2
4.35Single8IBUErythromycin A8IBU-Motilin-Erythromycin A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
4.35Consensuschemokine_offOrthosteric Ligandcxcr_off
4.35Consensuscxcr4_offOrthosteric Ligand4RWS-CXCR4-vMIP-II
4.35Consensuscxcr_offOrthosteric Ligandcxcr4_off
4.35Consensusgalanin_onOrthosteric Ligandgal2_on gal1_on
4.35Consensusnts1_offOrthosteric Ligand6Z4Q-NTS1-SR142948A 6Z4S-NTS1-SR48692
4.35Consensusnts_offOrthosteric Ligandnts1_off
4.17Single4BUONeurotensin4BUO-NTS1-Neurotensin
4.17Single4RWSvMIP-II4RWS-CXCR4-vMIP-II
4.17Single5TZYMK8666; PubChem 1270535975TZY-FFA1 (GPR40)-MK8666; PubChem 127053597
4.17Single6M1HMaxadilan6M1H-PAC1-Maxadilan-Gs/&β;1/&γ;2
4.17Single7SHFPI; PE7SHF-GPR158-PI; PE-B5; RGS7
4.17Consensusgal2_onOrthosteric Ligand7WQ4-GAL2-Galanin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
4.17Consensusgs_galaninOrthosteric Ligand7WQ4-GAL2-Galanin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
4.00Single6KNMJN241-96KNM-Apelin-JN241-9
4.00Single7S8LCortistatin-147S8L-MRGPRX2-Cortistatin-14-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
4.00Consensusmotilin_onOrthosteric Ligand8IBV-Motilin-Motilin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IBU-Motilin-Erythromycin A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
3.85Single7L0RNeurotensin7L0R-NTS1-Neurotensin-Gi1/&β;1/&γ;1
3.85Single7RTBPeptide-197RTB-GLP-1-Peptide-19-Gs/&β;1/&γ;2
3.70Single7SHFPI; PE7SHF-GPR158-PI; PE-B5; RGS7
3.57Single7W55Neuromedin-U-257W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
3.03Single7TYWCalcitonin-17TYW-CT (AMY1)-Calcitonin-1-Gs/&β;1/&γ;2; RAMP1
2.94Single7TYFAmylin7TYF-CT (AMY1)-Amylin-Gs/&β;1/&γ;2; RAMP1
2.94Single7TYIAmylin7TYI-CT-Amylin-Gs/&β;1/&γ;2
2.94Single7TYNCalcitonin-17TYN-CT-Calcitonin-1-Gs/&β;1/&γ;2
2.86Single7TYHCalcitonin-17TYH-CT (AMY2)-Calcitonin-1-Gs/&β;1/&γ;2; RAMP2
2.78Single7TZFAmylin7TZF-CT (AMY3)-Amylin-Gs/&β;1/&γ;2; RAMP3
2.78Single8F0KPramlintide analogue san3858F0K-CT (AMY3)-Pramlintide analogue san385-Gs/&β;1/&γ;2; RAMP3
2.70Single7TYYCalcitonin-17TYY-CT (AMY2)-Calcitonin-1-Gs/&β;1/&γ;2; RAMP2
2.70Single9AUCCalcitonin gene-related peptide-19AUC-CT-Calcitonin gene-related peptide-1-Gs/&β;1/&γ;2; RAMP1
2.56Single8F2APramlintide analogue san3858F2A-CT (AMY3)-Pramlintide analogue san385-Gs/&β;1/&γ;2; RAMP3
2.44Single7TYOCalcitonin7TYO-CT-Calcitonin-Gs/&β;1/&γ;2
2.38Single8F2BPramlintide analogue san458F2B-CT (AMY3)-Pramlintide analogue san45-Gs/&β;1/&γ;2; RAMP3
2.38Consensusgs_ctOrthosteric Ligand7TYN-CT-Calcitonin-1-Gs/&β;1/&γ;2 6NIY-CT-Adrenomedullin-Gs/&β;1/&γ;2 8F0J-CT-Pramlintide analogue san45-Gs/&β;1/&γ;2 7TYL-CT-Amylin-Gs/&β;1/&γ;2 8F0K-CT (AMY3)-Pramlintide analogue san385-Gs/&β;1/&γ;2; RAMP3
2.27Single8F0JPramlintide analogue san458F0J-CT-Pramlintide analogue san45-Gs/&β;1/&γ;2

PDB Summary
PDB 8GE9
Class A
SubFamily Amine
Type Adrenergic
SubType Beta2
Species Homo sapiens
Ligand Epinephrine
Other Ligand(s) -
Protein Partners Gs/Beta1/Gamma2
PDB Resolution 3.5
Date 2024-03-06
D.O.I. 10.1038/s41586-024-07153-1
Net Summary
Imin 3.21
Number of Linked Nodes 854
Number of Links 1000
Number of Hubs 147
Number of Links mediated by Hubs 541
Number of Communities 32
Number of Nodes involved in Communities 208
Number of Links involved in Communities 278
Path Summary
Number Of Nodes in MetaPath 128
Number Of Links MetaPath 127
Number of Shortest Paths 3674311
Length Of Smallest Path 3
Average Path Length 50.1008
Length of Longest Path 85
Minimum Path Strength 1.28
Average Path Strength 7.17543
Maximum Path Strength 22.34
Minimum Path Correlation 0.7
Average Path Correlation 0.990255
Maximum Path Correlation 1
Minimum % Of Corr. Nodes 1.49254
Average % Of Corr. Nodes 28.5823
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 51.7818
Maximum Path Hubs % 100
AnnotationTypeLinks
Gene OntologyMolecular Function
Gene OntologyBiological Process
Gene OntologyCellular Component
SCOP2Domain Identifier
SCOP2Family Identifier
Membrane Protein Annotations-• Orientations of Proteins in Membranes database (OPM)   • Protein Data Bank of Transmembrane Proteins (PDBTM)   • MemProtMD


Details about the values in these tables can be found in the corresponding documentation page .
CodeG1I
PDB ResiduesL:L:?1
Environment DetailsOpen EMBL-EBI Page
CodeG1I
Name(5R,6R)-6-(methylamino)-5,6,7,8-tetrahydronaphthalene-1,2,5-triol
Synonyms
Identifier(5~{R},6~{R})-6-(methylamino)-5,6,7,8-tetrahydronaphthalene-1,2,5-triol
FormulaC11 H15 N O3
Molecular Weight209.242
SMILESCN[C@@H]1CCc2c(ccc(c2O)O)[C@H]1O
PubChem12353638
Formal Charge0
Total Atoms30
Total Chiral Atoms2
Total Bonds31
Total Aromatic Bonds6

PDBsumOpen PDBsum Page
ChainA
ProteinG Protein α Sub unit
UniProtP63092
Sequence
>8GE9_Chain_A
QRNEEKAQR EANKKIEKQ LQKDKQVYR ATHRLLLLG AGESGKSTI 
VKQMRGIFE TKFQVDKVN FHMFDVGGQ RDERRKWIQ CFNDVTAII 
FVVASSSYN MVIRTNRLQ EALNLFKSI WNNRWLRTI SVILFLNKQ 
DLLAEKVLA GKSKIEDYF PEFARYTTP EDATPEPGE DPRVTRAKY 
FIRDEFLRI STASGDGRH YCYPHFTCA VDTENIRRV FNDCRDIIQ 
RMHLRQYEL L


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainB
ProteinG Protein β Sub unit
UniProtP62873
Sequence
>8GE9_Chain_B
QLRQEAEQL KNQIRDARK ACADATLSQ ITNNIDPVG RIQMRTRRT 
LRGHLAKIY AMHWGTDSR LLVSASQDG KLIIWDSYT TNKVHAIPL 
RSSWVMTCA YAPSGNYVA CGGLDNICS IYNLKTVRV SRELAGHTG 
YLSCCRFLD DNQIVTSSG DTTCALWDI ETGQQTTTF TGHTGDVMS 
LSLAPDTRL FVSGACDAS AKLWDVREG MCRQTFTGH ESDINAICF 
FPNGNAFAT GSDDATCRL FDLRADQEL MTYSHDNII CGITSVSFS 
KSGRLLLAG YDDFNCNVW DALKADRAG VLAGHDNRV SCLGVTDDG 
MAVATGSWD SFLKIWN


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainG
ProteinG Protein γ Sub unit
UniProtP59768
Sequence
>8GE9_Chain_G
QARKLVEQL KMEANIDRI KVSKAAADL MAYCEAHAK EDPLLTPVP 
ASENPFR


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainR
ProteinReceptor
UniProtP07550
Sequence
>8GE9_Chain_R
EVWVVGMGI VMSLIVLAI VFGNVLVIT AIAKFERLQ TVTNYFITS 
LACADLVMG LAVVPFGAA HILTKTWTF GNFWCEFWT SIDVLCVTA 
SIETLCVIA VDRYFAITS PFKYQSLLT KNKARVIIL MVWIVSGLT 
SFLPIQMHW YRATHQEAI NCYAEETCC DFFTNQAYA IASSIVSFY 
VPLVIMVFV YSRVFQEAK RQLQKIDKS EGRHKALKT LGIIMGTFT 
LCWLPFFIV NIVHVIQDN LIRKEVYIL LNWIGYVNS GFNPLIYCR 
SPDFRIAFQ ELL


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  




This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
2R4RAAmineAdrenergicβ2Homo sapiens---3.42007-11-0610.1038/nature06325
2R4SAAmineAdrenergicβ2Homo sapiens---3.42007-11-0610.1038/nature06325
2RH1AAmineAdrenergicβ2Homo sapiens(S)-Carazolol--2.42007-10-3010.1126/science.1150577
3D4SAAmineAdrenergicβ2Homo sapiensTimolol Maleate--2.82008-06-1710.1016/j.str.2008.05.001
3KJ6AAmineAdrenergicβ2Homo sapiens---3.42010-02-1610.1038/nature08650
3NY8AAmineAdrenergicβ2Homo sapiensICI 118-551--2.842010-08-1110.1021/ja105108q
3NY9AAmineAdrenergicβ2Homo sapiensPubChem 913103--2.842010-08-1110.1021/ja105108q
3NYAAAmineAdrenergicβ2Homo sapiens(S)-Alprenolol--3.162010-08-1110.1021/ja105108q
3P0GAAmineAdrenergicβ2Homo sapiensBI167107--3.52011-01-1910.1038/nature09648
3PDSAAmineAdrenergicβ2Homo sapiensHydroxybenzylisoproterenol--3.52011-01-1210.1038/nature09665
3SN6AAmineAdrenergicβ2Homo sapiensBI167107-Gs/&β;1/&γ;23.22011-07-2010.1038/nature10361
4GBRAAmineAdrenergicβ2Homo sapiens(S)-Carazolol--3.992012-10-2410.1371/journal.pone.0046039
4LDEAAmineAdrenergicβ2Homo sapiensBI167107--2.792013-09-2510.1038/nature12572
4LDLAAmineAdrenergicβ2Homo sapiensHydroxybenzylisoproterenol--3.12013-09-2510.1038/nature12572
4LDOAAmineAdrenergicβ2Homo sapiensL-Epinephrine--3.22013-09-2510.1038/nature12572
4QKXAAmineAdrenergicβ2Homo sapiensPubChem 76210628--3.32014-07-2310.1073/pnas.1410415111
5D5AAAmineAdrenergicβ2Homo sapiens(S)-Carazolol--2.482016-01-1310.1107/S2059798315021683
5D5BAAmineAdrenergicβ2Homo sapiens(S)-Carazolol--3.82016-01-1310.1107/S2059798315021683
5D6LAAmineAdrenergicβ2Homo sapiens(S)-Carazolol--3.22016-08-1710.1038/nprot.2017.057
5JQHAAmineAdrenergicβ2Homo sapiens(S)-Carazolol--3.22016-07-1310.1038/nature18636
5X7DAAmineAdrenergicβ2Homo sapiens(S)-CarazololPubChem 129318963-2.72017-08-1610.1038/nature23652
6E67AAmineAdrenergicβ2Homo sapiensBI167107-Gs (fused)3.72019-06-0510.1016/j.cell.2019.04.021
6MXTAAmineAdrenergicβ2Homo sapiensSalmeterol--2.962018-11-1410.1038/s41589-018-0145-x
6N48AAmineAdrenergicβ2Homo sapiensBI167107PubChem 138454256-3.22019-06-2610.1126/science.aaw8981
6NI3AAmineAdrenergicβ2Homo sapiensBI167107-Gs/&β;1/&γ;23.82019-11-2010.1038/s41594-019-0330-y
6OBAAAmineAdrenergicβ2Homo sapiens(S)-AlprenololGTPL11074-3.12020-03-2510.1038/s41589-020-0549-2
6PRZAAmineAdrenergicβ2Homo sapiens(S)-Alprenolol--2.82019-11-1310.1107/S2052252519013137
6PS0AAmineAdrenergicβ2Homo sapiens(S)-Carazolol--3.42019-11-1310.1107/S2052252519013137
6PS1AAmineAdrenergicβ2Homo sapiensTimolol--3.22019-11-1310.1107/S2052252519013137
6PS2AAmineAdrenergicβ2Homo sapiens(S)-Alprenolol--2.42019-11-1310.1107/S2052252519013137
6PS3AAmineAdrenergicβ2Homo sapiens(S)-Carvedilol--2.52019-11-1310.1107/S2052252519013137
6PS4AAmineAdrenergicβ2Homo sapiensICI 118-551--2.62019-11-1310.1107/S2052252519013137
6PS5AAmineAdrenergicβ2Homo sapiens(S)-Propranolol--2.92019-11-1310.1107/S2052252519013137
6PS6AAmineAdrenergicβ2Homo sapiensTimolol--2.72019-11-1310.1107/S2052252519013137
7BZ2AAmineAdrenergicβ2Homo sapiensArformoterol-Gs/&β;1/&γ;23.822020-08-0510.1038/s41421-020-0176-9
7DHIAAmineAdrenergicβ2Homo sapiensSalbutamol-Gs/&β;1/&γ;23.262020-12-1610.1093/nsr/nwaa284
7DHRAAmineAdrenergicβ2Homo sapiensIsoprenaline-Gs/&β;1/&γ;23.82020-12-1610.1093/nsr/nwaa284
7XKAAAmineAdrenergicβ2Homo sapiensEpinephrine--3.12023-04-2610.1038/s41467-023-37808-y
8GDZAAmineAdrenergicβ2Homo sapiensEpinephrine-Gs/&β;1/&γ;23.52024-03-0610.1038/s41586-024-07153-1
8GE1AAmineAdrenergicβ2Homo sapiensEpinephrine-Gs/&β;1/&γ;23.42024-03-0610.1038/s41586-024-07153-1
8GE3AAmineAdrenergicβ2Homo sapiensEpinephrine-Gs/&β;1/&γ;23.32024-03-0610.1038/s41586-024-07153-1
8GE4AAmineAdrenergicβ2Homo sapiensEpinephrine-Gs/&β;1/&γ;23.32024-03-0610.1038/s41586-024-07153-1
8GE6AAmineAdrenergicβ2Homo sapiensEpinephrine-Gs/&β;1/&γ;23.42024-03-0610.1038/s41586-024-07153-1
8GE7AAmineAdrenergicβ2Homo sapiensEpinephrine-Gs/&β;1/&γ;23.42024-03-0610.1038/s41586-024-07153-1
8GE8AAmineAdrenergicβ2Homo sapiensEpinephrine-Gs/&β;1/&γ;23.42024-03-0610.1038/s41586-024-07153-1
8GEAAAmineAdrenergicβ2Homo sapiensEpinephrine-Gs/&β;1/&γ;23.52024-03-0610.1038/s41586-024-07153-1
8GEBAAmineAdrenergicβ2Homo sapiensEpinephrine-Gs/&β;1/&γ;23.62024-03-0610.1038/s41586-024-07153-1
8GECAAmineAdrenergicβ2Homo sapiensEpinephrine-Gs/&β;1/&γ;23.52024-03-0610.1038/s41586-024-07153-1
8GEDAAmineAdrenergicβ2Homo sapiensEpinephrine-Gs/&β;1/&γ;23.52024-03-0610.1038/s41586-024-07153-1
8GEEAAmineAdrenergicβ2Homo sapiensEpinephrine-Gs/&β;1/&γ;23.72024-03-0610.1038/s41586-024-07153-1
8GEFAAmineAdrenergicβ2Homo sapiensEpinephrine-Gs/&β;1/&γ;23.82024-03-0610.1038/s41586-024-07153-1
8GEGAAmineAdrenergicβ2Homo sapiensEpinephrine-Gs/&β;1/&γ;23.82024-03-0610.1038/s41586-024-07153-1
8GEHAAmineAdrenergicβ2Homo sapiensEpinephrine-Gs/&β;1/&γ;242024-03-0610.1038/s41586-024-07153-1
8GEIAAmineAdrenergicβ2Homo sapiensEpinephrine-Gs/&β;1/&γ;24.12024-03-0610.1038/s41586-024-07153-1
8GEJAAmineAdrenergicβ2Homo sapiensEpinephrine-Gs/&β;1/&γ;24.22024-03-0610.1038/s41586-024-07153-1
8GFVAAmineAdrenergicβ2Homo sapiensEpinephrineGTPGs/&β;1/&γ;23.12024-03-0610.1038/s41586-024-07153-1
8GFWAAmineAdrenergicβ2Homo sapiensEpinephrineGTPGs/&β;1/&γ;232024-03-0610.1038/s41586-024-07153-1
8GFXAAmineAdrenergicβ2Homo sapiensEpinephrineGTPGs/&β;1/&γ;232024-03-0610.1038/s41586-024-07153-1
8GFYAAmineAdrenergicβ2Homo sapiensEpinephrineGTPGs/&β;1/&γ;232024-03-0610.1038/s41586-024-07153-1
8GFZAAmineAdrenergicβ2Homo sapiensEpinephrineGTPGs/&β;1/&γ;232024-03-0610.1038/s41586-024-07153-1
8GG0AAmineAdrenergicβ2Homo sapiensEpinephrineGTPGs/&β;1/&γ;22.92024-03-0610.1038/s41586-024-07153-1
8GG1AAmineAdrenergicβ2Homo sapiensEpinephrineGTPGs/&β;1/&γ;232024-03-0610.1038/s41586-024-07153-1
8GG2AAmineAdrenergicβ2Homo sapiensEpinephrineGTPGs/&β;1/&γ;232024-03-0610.1038/s41586-024-07153-1
8GG3AAmineAdrenergicβ2Homo sapiensEpinephrineGTPGs/&β;1/&γ;23.12024-03-0610.1038/s41586-024-07153-1
8GG4AAmineAdrenergicβ2Homo sapiensEpinephrineGTPGs/&β;1/&γ;23.22024-03-0610.1038/s41586-024-07153-1
8GG5AAmineAdrenergicβ2Homo sapiensEpinephrineGTPGs/&β;1/&γ;23.22024-03-0610.1038/s41586-024-07153-1
8GG6AAmineAdrenergicβ2Homo sapiensEpinephrineGTPGs/&β;1/&γ;23.32024-03-0610.1038/s41586-024-07153-1
8GG7AAmineAdrenergicβ2Homo sapiensEpinephrineGTPGs/&β;1/&γ;23.32024-03-0610.1038/s41586-024-07153-1
8GG8AAmineAdrenergicβ2Homo sapiensEpinephrineGTPGs/&β;1/&γ;23.32024-03-0610.1038/s41586-024-07153-1
8GG9AAmineAdrenergicβ2Homo sapiensEpinephrineGTPGs/&β;1/&γ;23.42024-03-0610.1038/s41586-024-07153-1
8GGAAAmineAdrenergicβ2Homo sapiensEpinephrineGTPGs/&β;1/&γ;23.52024-03-0610.1038/s41586-024-07153-1
8GGBAAmineAdrenergicβ2Homo sapiensEpinephrineGTPGs/&β;1/&γ;23.52024-03-0610.1038/s41586-024-07153-1
8GGCAAmineAdrenergicβ2Homo sapiensEpinephrineGTPGs/&β;1/&γ;23.42024-03-0610.1038/s41586-024-07153-1
8GGEAAmineAdrenergicβ2Homo sapiensEpinephrineGTPGs/&β;1/&γ;23.52024-03-0610.1038/s41586-024-07153-1
8GGFAAmineAdrenergicβ2Homo sapiensEpinephrineGTPGs/&β;1/&γ;23.62024-03-0610.1038/s41586-024-07153-1
8GGIAAmineAdrenergicβ2Homo sapiensEpinephrine--3.52024-03-0610.1038/s41586-024-07153-1
8GGJAAmineAdrenergicβ2Homo sapiensEpinephrine--3.52024-03-0610.1038/s41586-024-07153-1
8GGKAAmineAdrenergicβ2Homo sapiensEpinephrine--3.32024-03-0610.1038/s41586-024-07153-1
8GGLAAmineAdrenergicβ2Homo sapiensEpinephrine--3.22024-03-0610.1038/s41586-024-07153-1
8GGMAAmineAdrenergicβ2Homo sapiensEpinephrine--3.22024-03-0610.1038/s41586-024-07153-1
8GGNAAmineAdrenergicβ2Homo sapiensEpinephrine--3.32024-03-0610.1038/s41586-024-07153-1
8GGOAAmineAdrenergicβ2Homo sapiensEpinephrine--3.22024-03-0610.1038/s41586-024-07153-1
8GGPAAmineAdrenergicβ2Homo sapiensEpinephrine--3.22024-03-0610.1038/s41586-024-07153-1
8GGQAAmineAdrenergicβ2Homo sapiensEpinephrine--3.42024-03-0610.1038/s41586-024-07153-1
8GGRAAmineAdrenergicβ2Homo sapiensEpinephrine--3.42024-03-0610.1038/s41586-024-07153-1
8GGSAAmineAdrenergicβ2Homo sapiensEpinephrine--3.52024-03-0610.1038/s41586-024-07153-1
8GGTAAmineAdrenergicβ2Homo sapiensEpinephrine--3.52024-03-0610.1038/s41586-024-07153-1
8GGUAAmineAdrenergicβ2Homo sapiensEpinephrine--3.42024-03-0610.1038/s41586-024-07153-1
8GGVAAmineAdrenergicβ2Homo sapiensEpinephrine--3.52024-03-0610.1038/s41586-024-07153-1
8GGWAAmineAdrenergicβ2Homo sapiensEpinephrine--3.62024-03-0610.1038/s41586-024-07153-1
8GGXAAmineAdrenergicβ2Homo sapiensEpinephrine--3.62024-03-0610.1038/s41586-024-07153-1
8GGYAAmineAdrenergicβ2Homo sapiensEpinephrine--3.92024-03-0610.1038/s41586-024-07153-1
8GGZAAmineAdrenergicβ2Homo sapiensEpinephrine--3.92024-03-0610.1038/s41586-024-07153-1
8GH0AAmineAdrenergicβ2Homo sapiensEpinephrine--42024-03-0610.1038/s41586-024-07153-1
8GH1AAmineAdrenergicβ2Homo sapiensEpinephrine--4.12024-03-0610.1038/s41586-024-07153-1
8JJ8AAmineAdrenergicβ2Homo sapiensFormoterol--3.22023-09-0610.1038/s41589-023-01389-0
8JJLAAmineAdrenergicβ2Homo sapiensOlodaterol--3.22023-09-0610.1038/s41589-023-01389-0
8JJOAAmineAdrenergicβ2Homo sapiensAlprenolol--3.42023-09-0610.1038/s41589-023-01389-0
8UNLAAmineAdrenergicβ2Homo sapiensEpinephrineGTPGs/&β;1/&γ;23.32024-03-0610.1038/s41586-024-07153-1
8UNMAAmineAdrenergicβ2Homo sapiensEpinephrineGTPGs/&β;1/&γ;23.42024-03-0610.1038/s41586-024-07153-1
8UNNAAmineAdrenergicβ2Homo sapiensEpinephrineGTPGs/&β;1/&γ;23.42024-03-0610.1038/s41586-024-07153-1
8UNOAAmineAdrenergicβ2Homo sapiensEpinephrineGTPGs/&β;1/&γ;23.32024-03-0610.1038/s41586-024-07153-1
8UNPAAmineAdrenergicβ2Homo sapiensEpinephrineGTPGs/&β;1/&γ;23.32024-03-0610.1038/s41586-024-07153-1
8UNQAAmineAdrenergicβ2Homo sapiensEpinephrineGTPGs/&β;1/&γ;23.32024-03-0610.1038/s41586-024-07153-1
8UNRAAmineAdrenergicβ2Homo sapiensEpinephrineGTPGs/&β;1/&γ;23.42024-03-0610.1038/s41586-024-07153-1
8UNSAAmineAdrenergicβ2Homo sapiensEpinephrineGTPGs/&β;1/&γ;23.42024-03-0610.1038/s41586-024-07153-1
8UNTAAmineAdrenergicβ2Homo sapiensEpinephrineGTPGs/&β;1/&γ;23.42024-03-0610.1038/s41586-024-07153-1
8UNUAAmineAdrenergicβ2Homo sapiensEpinephrineGTPGs/&β;1/&γ;23.52024-03-0610.1038/s41586-024-07153-1
8UNVAAmineAdrenergicβ2Homo sapiensEpinephrineGTPGs/&β;1/&γ;23.32024-03-0610.1038/s41586-024-07153-1
8UNWAAmineAdrenergicβ2Homo sapiensEpinephrineGTPGs/&β;1/&γ;23.42024-03-0610.1038/s41586-024-07153-1
8UNXAAmineAdrenergicβ2Homo sapiensEpinephrineGTPGs/&β;1/&γ;23.62024-03-0610.1038/s41586-024-07153-1
8UNYAAmineAdrenergicβ2Homo sapiensEpinephrineGTPGs/&β;1/&γ;23.62024-03-0610.1038/s41586-024-07153-1
8UNZAAmineAdrenergicβ2Homo sapiensEpinephrineGTPGs/&β;1/&γ;23.82024-03-0610.1038/s41586-024-07153-1
8UO0AAmineAdrenergicβ2Homo sapiensEpinephrineGTPGs/&β;1/&γ;23.52024-03-0610.1038/s41586-024-07153-1
8UO1AAmineAdrenergicβ2Homo sapiensEpinephrineGTP; MgGs/&β;1/&γ;23.62024-03-0610.1038/s41586-024-07153-1
8UO2AAmineAdrenergicβ2Homo sapiensEpinephrineGTPGs/&β;1/&γ;23.62024-03-0610.1038/s41586-024-07153-1
8UO3AAmineAdrenergicβ2Homo sapiensEpinephrineGTP; MgGs/&β;1/&γ;23.52024-03-0610.1038/s41586-024-07153-1
8UO4AAmineAdrenergicβ2Homo sapiensEpinephrineGTP; MgGs/&β;1/&γ;242024-03-0610.1038/s41586-024-07153-1




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Download 8GE9.zip



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