Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg Int. Strength Num Of Links Community ConSurf
1L:L:?1 9.234171210
2R:R:M36 3.3225405
3R:R:I47 2.8375408
4R:R:N51 4.3409
5R:R:F61 4.325406
6R:R:F71 5.11408
7R:R:L75 5.322559
8R:R:D79 6.134559
9R:R:L80 3.5875477
10R:R:M82 3.8625407
11R:R:W99 5.30714737
12R:R:F101 4.86435
13R:R:F108 4.8125425
14R:R:D113 8.64417
15R:R:L115 3.96405
16R:R:V117 4.88416
17R:R:Y132 8.215408
18R:R:W158 4.6825409
19R:R:Y174 7.14425
20R:R:D192 3.9225443
21R:R:F194 4.724541
22R:R:Y199 5.02626
23R:R:F208 7.03667618
24R:R:Y219 4.382599
25R:R:R221 3.535405
26R:R:F223 3.3575406
27R:R:M279 3.0975498
28R:R:W286 5.43875818
29R:R:L287 4.255406
30R:R:F289 8.3516
31R:R:F290 8.654517
32R:R:N293 6.16415
33R:R:H296 7.0925413
34R:R:L311 3.04405
35R:R:Y316 8.018516
36R:R:F332 5.47833689
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
1L:L:?1 R:R:Y316 16.08743.41YesYes106
2R:R:W313 R:R:Y316 21.4663.86NoYes056
3R:R:I94 R:R:W313 14.48194.7NoNo055
4R:R:I94 R:R:M40 12.70882.92NoNo056
5L:L:?1 R:R:V117 59.20868.66YesYes106
6R:R:M82 R:R:V117 68.53343.04YesYes076
7R:R:M82 R:R:S319 75.82036.13YesNo079
8R:R:D79 R:R:S319 75.59337.36YesNo099
9R:R:D79 R:R:N51 51.85696.73YesYes099
10R:R:N51 R:R:P323 39.72654.89YesNo099
11R:R:P323 R:R:V54 34.99113.53NoNo099
12R:R:C327 R:R:V54 33.78025.12NoNo079
13R:R:C327 R:R:F332 31.3266.98NoYes079
14R:R:F332 R:R:F336 15.69272.14YesNo097
15R:R:A57 R:R:F336 12.93582.77NoNo087
16R:R:A335 R:R:A57 11.54121.79NoNo078
17R:R:A335 R:R:F61 10.13572.77NoYes076
18L:L:?1 R:R:V114 24.78515.77YesNo005
19R:R:S165 R:R:V114 23.86088.08NoNo075
20R:R:L115 R:R:S165 23.42834.5YesNo057
21R:R:L115 R:R:W158 44.81863.42YesYes059
22R:R:S74 R:R:W158 63.44674.94NoYes099
23R:R:I154 R:R:S74 66.81983.1NoNo089
24R:R:F71 R:R:I154 63.89535.02YesNo088
25R:R:D130 R:R:F71 24.9044.78NoYes088
26L:L:?1 R:R:T118 46.34852.85YesNo106
27R:R:S161 R:R:T118 46.13226.4NoNo086
28R:R:L115 R:R:S161 23.60674.5YesNo058
29R:R:A119 R:R:S161 22.74183.42NoNo078
30R:R:A119 R:R:W158 22.50397.78NoYes079
31R:R:F71 R:R:V126 18.73077.87YesNo087
32R:R:S74 R:R:T123 18.82263.2NoNo098
33R:R:D79 R:R:L75 56.0035.43YesYes599
34R:R:L75 R:R:T123 18.29294.42YesNo098
35R:R:L124 R:R:L75 54.15434.15NoYes089
36L:L:?1 R:R:S203 10011.63YesNo005
37R:R:S203 R:R:Y199 99.02167.63NoYes056
38R:R:I169 R:R:Y199 64.21433.63NoYes256
39R:R:I169 R:R:S111 67.17126.19NoNo256
40R:R:F166 R:R:S111 32.915310.57NoNo246
41R:R:F108 R:R:F166 31.45587.5YesNo254
42R:R:F104 R:R:F108 56.81933.22NoYes015
43R:R:F104 R:R:W105 53.754312.03NoNo015
44R:R:F101 R:R:W105 50.67843.01YesNo055
45R:R:Q170 R:R:S111 32.91534.33NoNo246
46R:R:F108 R:R:Q170 31.45583.51YesNo254
47R:R:F101 R:R:W99 22.39588.02YesYes357
48R:R:F101 R:R:T100 16.13065.19YesNo052
49R:R:Y174 R:R:Y199 26.26634.96YesYes256
50R:R:V117 R:R:W286 21.40664.9YesYes168
51L:L:?1 R:R:F290 29.37468.26YesYes107
52R:R:V126 R:R:V157 12.5251.6NoNo077
53R:R:L124 R:R:Y326 11.58444.69NoNo089
54R:R:L124 R:R:M215 44.47272.83NoNo088
55R:R:M215 R:R:Y219 38.08853.59NoYes989
56R:R:A128 R:R:Y219 25.09874NoYes089
57R:R:A128 R:R:V218 23.79591.7NoNo086
58R:R:V218 R:R:Y132 22.48238.83NoYes068
59R:R:F133 R:R:Y132 10.17354.13NoYes058
60R:R:D130 R:R:Y141 18.74169.2NoNo087
61R:R:R221 R:R:Y132 10.17356.17YesYes058
62R:R:L145 R:R:Y141 12.53584.69NoNo077
63R:R:A150 R:R:F71 18.74162.77NoYes078
64R:R:A150 R:R:Y70 12.53581.33NoNo074
65R:R:P168 R:R:Y199 10.56814.17NoYes056
66R:R:R175 R:R:Y174 27.32587.2NoYes025
67R:R:R175 R:R:Y185 24.060824.69NoNo021
68R:R:A181 R:R:Y185 22.4122.67NoNo041
69R:R:A181 R:R:F194 17.29284.16NoYes441
70L:L:?1 R:R:N293 24.83385.32YesYes105
71R:R:H296 R:R:N293 16.86046.38YesYes135
72R:R:I294 R:R:S204 11.05473.1NoNo065
73R:R:F208 R:R:F290 18.606419.29YesYes187
74R:R:F208 R:R:L287 20.0933.65YesYes086
75R:R:L287 R:R:P288 14.74133.28YesNo069
76R:R:L311 R:R:P288 12.93583.28YesNo059
77R:R:H296 R:R:I303 11.54123.98YesNo033
78R:R:T100 R:R:T98 12.9251.57NoNo025
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


2D representation of the interactions of this orthosteric/allosteric ligand.


Links and nodes colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
L:L:?1 R:R:D113 15.77 1 Yes Yes 0 7 0 1
L:L:?1 R:R:V114 5.77 1 Yes No 0 5 0 1
L:L:?1 R:R:V117 8.66 1 Yes Yes 0 6 0 1
L:L:?1 R:R:T118 2.85 1 Yes No 0 6 0 1
L:L:?1 R:R:F193 14.15 1 Yes No 0 4 0 1
L:L:?1 R:R:S203 11.63 1 Yes No 0 5 0 1
L:L:?1 R:R:S207 8.72 1 Yes No 0 5 0 1
L:L:?1 R:R:F289 12.97 1 Yes Yes 0 6 0 1
L:L:?1 R:R:F290 8.26 1 Yes Yes 0 7 0 1
L:L:?1 R:R:N293 5.32 1 Yes Yes 0 5 0 1
L:L:?1 R:R:N312 13.3 1 Yes No 0 5 0 1
L:L:?1 R:R:Y316 3.41 1 Yes Yes 0 6 0 1
R:R:M82 R:R:V86 3.04 0 Yes No 7 7 2 2
R:R:M82 R:R:V117 3.04 0 Yes Yes 7 6 2 1
R:R:D113 R:R:V86 4.38 1 Yes No 7 7 1 2
R:R:V86 R:R:Y316 5.05 1 No Yes 7 6 2 1
R:R:D113 R:R:V117 2.92 1 Yes Yes 7 6 1 1
R:R:D113 R:R:Y316 11.49 1 Yes Yes 7 6 1 1
R:R:S165 R:R:V114 8.08 0 No No 7 5 2 1
R:R:V117 R:R:W286 4.9 1 Yes Yes 6 8 1 2
R:R:S161 R:R:T118 6.4 0 No No 8 6 2 1
R:R:S207 R:R:T118 7.99 1 No No 5 6 1 1
R:R:F193 R:R:T195 5.19 0 No No 4 3 1 2
R:R:T195 R:R:Y199 6.24 0 No Yes 3 6 2 2
R:R:S203 R:R:Y199 7.63 0 No Yes 5 6 1 2
R:R:F290 R:R:S204 5.28 1 Yes No 7 5 1 2
R:R:N293 R:R:S204 5.96 1 Yes No 5 5 1 2
R:R:F208 R:R:W286 3.01 1 Yes Yes 8 8 2 2
R:R:F208 R:R:F290 19.29 1 Yes Yes 8 7 2 1
R:R:F289 R:R:W286 4.01 1 Yes Yes 6 8 1 2
R:R:F290 R:R:W286 4.01 1 Yes Yes 7 8 1 2
R:R:F289 R:R:F290 6.43 1 Yes Yes 6 7 1 1
R:R:F289 R:R:Y308 7.22 1 Yes No 6 5 1 2
R:R:F289 R:R:N312 10.87 1 Yes No 6 5 1 1
R:R:H296 R:R:N293 6.38 1 Yes Yes 3 5 2 1
R:R:N293 R:R:Y308 6.98 1 Yes No 5 5 1 2
R:R:H296 R:R:Y308 15.24 1 Yes No 3 5 2 2
R:R:N312 R:R:Y316 16.28 1 No Yes 5 6 1 1
R:R:W313 R:R:Y316 3.86 0 No Yes 5 6 2 1
R:R:F193 R:R:T110 2.59 0 No No 4 4 1 2

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB 8GG2_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.
Net Summary
Imin 2.85
Number of Linked Nodes 259
Number of Links 282
Number of Hubs 36
Number of Links mediated by Hubs 145
Number of Communities 9
Number of Nodes involved in Communities 51
Number of Links involved in Communities 70
Path Summary
Number Of Nodes in MetaPath 79
Number Of Links MetaPath 78
Number of Shortest Paths 45344
Length Of Smallest Path 3
Average Path Length 13.7875
Length of Longest Path 32
Minimum Path Strength 1.26
Average Path Strength 5.49783
Maximum Path Strength 23.63
Minimum Path Correlation 0.7
Average Path Correlation 0.97584
Maximum Path Correlation 1
Minimum % Of Corr. Nodes 7.69231
Average % Of Corr. Nodes 80.9231
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 41.6871
Maximum Path Hubs % 100
AnnotationTypeLinks
Gene OntologyMolecular Function• amyloid-beta binding   • binding   • peptide binding   • protein binding   • enzyme binding   • adenylate cyclase binding   • G protein-coupled amine receptor activity   • molecular transducer activity   • beta2-adrenergic receptor activity   • G protein-coupled receptor activity   • transmembrane signaling receptor activity   • signaling receptor activity   • beta-adrenergic receptor activity   • adrenergic receptor activity   • protein-containing complex binding   • potassium channel regulator activity   • channel regulator activity   • ion channel regulator activity   • molecular function regulator activity   • transporter regulator activity   • identical protein binding   • protein homodimerization activity   • protein dimerization activity   • cation binding   • ion binding   • catecholamine binding   • norepinephrine binding   • small molecule binding   • multicellular organismal process   • response to nutrient levels   • multicellular organismal-level homeostasis   • response to stimulus   • homeostatic process   • response to dietary excess   • diet induced thermogenesis   • temperature homeostasis   • energy homeostasis   • adaptive thermogenesis   • response to stress   • response to abiotic stimulus   • response to cold   • response to temperature stimulus
Gene OntologyBiological Process• multicellular organismal process   • response to nutrient levels   • multicellular organismal-level homeostasis   • response to stimulus   • homeostatic process   • response to dietary excess   • diet induced thermogenesis   • temperature homeostasis   • energy homeostasis   • adaptive thermogenesis   • response to stress   • response to abiotic stimulus   • response to cold   • response to temperature stimulus   • cellular response to stimulus   • regulation of biological process   • regulation of cellular process   • signaling   • biological regulation   • cell communication   • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway   • adenylate cyclase-inhibiting adrenergic receptor signaling pathway   • adenylate cyclase-modulating G protein-coupled receptor signaling pathway   • adrenergic receptor signaling pathway   • G protein-coupled receptor signaling pathway   • cellular process   • signal transduction   • regulation of developmental process   • positive regulation of biological process   • regulation of biomineral tissue development   • regulation of bone mineralization   • positive regulation of ossification   • positive regulation of developmental process   • multicellular organism development   • positive regulation of biomineral tissue development   • ossification   • anatomical structure development   • biomineral tissue development   • regulation of multicellular organismal process   • developmental process   • regulation of multicellular organismal development   • bone mineralization   • animal organ development   • tissue development   • positive regulation of bone mineralization   • positive regulation of multicellular organismal process   • regulation of ossification   • regulation of multicellular organism growth   • regulation of growth   • regulation of developmental growth   • negative regulation of multicellular organism growth   • developmental growth   • negative regulation of developmental process   • growth   • negative regulation of biological process   • multicellular organism growth   • negative regulation of developmental growth   • negative regulation of growth   • negative regulation of multicellular organismal process   • adenylate cyclase-activating adrenergic receptor signaling pathway   • adenylate cyclase-activating G protein-coupled receptor signaling pathway   • fat cell differentiation   • cellular developmental process   • brown fat cell differentiation   • cell differentiation   • negative regulation of cardiac muscle cell apoptotic process   • muscle cell apoptotic process   • negative regulation of programmed cell death   • regulation of apoptotic process   • regulation of cardiac muscle cell apoptotic process   • regulation of muscle cell apoptotic process   • regulation of programmed cell death   • cell death   • cardiac muscle cell apoptotic process   • negative regulation of apoptotic process   • regulation of striated muscle cell apoptotic process   • striated muscle cell apoptotic process   • negative regulation of muscle cell apoptotic process   • negative regulation of cellular process   • negative regulation of striated muscle cell apoptotic process   • apoptotic process   • programmed cell death   • system process   • regulation of system process   • muscle contraction   • muscle system process   • regulation of muscle system process   • negative regulation of muscle contraction   • smooth muscle contraction   • regulation of smooth muscle contraction   • regulation of muscle contraction   • negative regulation of smooth muscle contraction   • positive regulation of DNA-templated transcription   • RNA metabolic process   • positive regulation of macromolecule biosynthetic process   • regulation of primary metabolic process   • nucleobase-containing compound metabolic process   • RNA biosynthetic process   • nucleic acid biosynthetic process   • positive regulation of metabolic process   • DNA-templated transcription   • regulation of RNA metabolic process   • transcription by RNA polymerase II   • positive regulation of biosynthetic process   • positive regulation of macromolecule metabolic process   • regulation of nucleobase-containing compound metabolic process   • positive regulation of cellular process   • regulation of RNA biosynthetic process   • regulation of biosynthetic process   • regulation of transcription by RNA polymerase II   • primary metabolic process   • regulation of macromolecule metabolic process   • positive regulation of transcription by RNA polymerase II   • nucleobase-containing compound biosynthetic process   • gene expression   • macromolecule biosynthetic process   • nucleic acid metabolic process   • positive regulation of RNA metabolic process   • regulation of gene expression   • biosynthetic process   • positive regulation of RNA biosynthetic process   • metabolic process   • regulation of macromolecule biosynthetic process   • macromolecule metabolic process   • regulation of DNA-templated transcription   • regulation of metabolic process   • tissue remodeling   • bone remodeling   • anatomical structure homeostasis   • tissue homeostasis   • bone resorption   • localization   • import into cell   • transport   • receptor-mediated endocytosis   • endocytosis   • establishment of localization   • vesicle-mediated transport   • cellular localization   • endosome to lysosome transport   • intracellular transport   • lysosomal transport   • establishment of localization in cell   • vacuolar transport   • heart process   • regulation of actin filament-based process   • regulation of heart contraction   • cardiac muscle contraction   • striated muscle contraction   • circulatory system process   • actin filament-based process   • positive regulation of actin filament-based movement   • blood circulation   • cardiac muscle cell contraction   • regulation of cardiac muscle contraction   • positive regulation of cardiac muscle cell contraction   • actin filament-based movement   • regulation of blood circulation   • regulation of striated muscle contraction   • regulation of actin filament-based movement   • regulation of cardiac muscle cell contraction   • actin-mediated cell contraction   • heart contraction   • positive regulation of organelle organization   • catabolic process   • regulation of cellular component organization   • positive regulation of cellular component organization   • regulation of autophagosome maturation   • macroautophagy   • autophagy   • protein-containing complex disassembly   • regulation of autophagy   • regulation of protein-containing complex disassembly   • cellular component organization   • autophagosome maturation   • cellular component organization or biogenesis   • positive regulation of macroautophagy   • process utilizing autophagic mechanism   • positive regulation of protein-containing complex disassembly   • cellular component disassembly   • positive regulation of autophagy   • protein-containing complex organization   • regulation of catabolic process   • positive regulation of autophagosome maturation   • regulation of organelle organization   • positive regulation of catabolic process   • organelle organization   • regulation of macroautophagy   • positive regulation of cardiac muscle cell apoptotic process   • positive regulation of programmed cell death   • positive regulation of striated muscle cell apoptotic process   • positive regulation of apoptotic process   • positive regulation of muscle cell apoptotic process   • lipophagy   • positive regulation of lipophagy   • regulation of lipophagy   • response to psychosocial stress   • regulation of cold-induced thermogenesis   • cold-induced thermogenesis   • positive regulation of cold-induced thermogenesis   • positive regulation of cell communication   • positive regulation of signal transduction   • regulation of signal transduction   • intracellular signal transduction   • positive regulation of response to stimulus   • regulation of intracellular signal transduction   • intracellular signaling cassette   • regulation of signaling   • positive regulation of MAPK cascade   • positive regulation of intracellular signal transduction   • regulation of MAPK cascade   • regulation of response to stimulus   • MAPK cascade   • regulation of cell communication   • positive regulation of signaling   • cell surface receptor signaling pathway   • ligand-gated ion channel signaling pathway   • ionotropic glutamate receptor signaling pathway   • glutamate receptor signaling pathway   • AMPA selective glutamate receptor signaling pathway   • regulation of tube diameter   • regulation of systemic arterial blood pressure mediated by a chemical signal   • regulation of blood pressure   • regulation of tube size   • norepinephrine-epinephrine-mediated vasodilation involved in regulation of systemic arterial blood pressure   • negative regulation of blood pressure   • regulation of systemic arterial blood pressure by norepinephrine-epinephrine   • regulation of systemic arterial blood pressure   • negative regulation of systemic arterial blood pressure   • vascular process in circulatory system   • regulation of biological quality   • blood vessel diameter maintenance   • vasodilation   • regulation of anatomical structure size   • negative regulation of signaling   • negative regulation of response to stimulus   • negative regulation of signal transduction   • negative regulation of G protein-coupled receptor signaling pathway   • negative regulation of cell communication   • regulation of G protein-coupled receptor signaling pathway   • positive regulation of cAMP/PKA signal transduction   • cAMP/PKA signal transduction   • regulation of cAMP/PKA signal transduction   • cellular response to nitrogen compound   • response to oxygen-containing compound   • response to nitrogen compound   • cellular response to amyloid-beta   • cellular response to oxygen-containing compound   • cellular response to chemical stimulus   • response to chemical   • response to amyloid-beta   • regulation of localization   • regulation of transport   • regulation of monoatomic ion transport   • regulation of sodium ion transport   • metal ion transport   • monoatomic ion transport   • regulation of metal ion transport   • monoatomic cation transport   • sodium ion transport   • heat generation   • regulation of postsynaptic membrane potential   • modulation of chemical synaptic transmission   • positive regulation of excitatory postsynaptic potential   • chemical synaptic transmission, postsynaptic   • synaptic signaling   • modulation of excitatory postsynaptic potential   • mini excitatory postsynaptic potential   • trans-synaptic signaling   • nervous system process   • cell-cell signaling   • chemical synaptic transmission   • regulation of nervous system process   • regulation of mini excitatory postsynaptic potential   • positive regulation of mini excitatory postsynaptic potential   • regulation of trans-synaptic signaling   • anterograde trans-synaptic signaling   • excitatory postsynaptic potential   • regulation of membrane potential   • cellular anatomical structure   • membrane   • membrane-bounded organelle   • intracellular anatomical structure   • dense core granule   • intracellular vesicle   • intracellular membrane-bounded organelle   • endomembrane system   • intracellular organelle   • cytoplasmic vesicle   • organelle   • secretory granule   • secretory vesicle   • cytoplasm
Gene OntologyCellular Component• cellular anatomical structure   • membrane   • membrane-bounded organelle   • intracellular anatomical structure   • dense core granule   • intracellular vesicle   • intracellular membrane-bounded organelle   • endomembrane system   • intracellular organelle   • cytoplasmic vesicle   • organelle   • secretory granule   • secretory vesicle   • cytoplasm   • vesicle   • neuronal dense core vesicle   • bounding membrane of organelle   • vesicle membrane   • clathrin-coated vesicle   • endocytic vesicle membrane   • coated vesicle   • endocytic vesicle   • clathrin-coated vesicle membrane   • clathrin-coated endocytic vesicle membrane   • clathrin-coated endocytic vesicle   • cytoplasmic vesicle membrane   • coated vesicle membrane   • organelle membrane   • protein-containing complex   • receptor complex   • intercellular bridge   • Golgi apparatus   • endosome membrane   • endosome   • intracellular membraneless organelle   • cilium   • plasma membrane bounded cell projection   • ciliary basal body   • cell projection   • microtubule organizing center   • cytoskeleton   • membraneless organelle   • microtubule cytoskeleton   • cell periphery   • apical part of cell   • plasma membrane   • plasma membrane region   • apical plasma membrane   • mitotic spindle   • spindle   • lytic vacuole   • vacuole   • lysosome   • early endosome   • nucleus   • protein binding   • binding   • G-protein beta-subunit binding   • fibroblast proliferation   • cell population proliferation   • cellular process   • cellular response to nitrogen compound   • cellular response to stimulus   • response to dopamine   • regulation of cellular process   • response to stimulus   • signaling   • cellular response to dopamine   • response to monoamine   • cell communication   • response to catecholamine   • adenylate cyclase-activating dopamine receptor signaling pathway   • cellular response to catecholamine stimulus   • signal transduction   • regulation of biological process   • G protein-coupled dopamine receptor signaling pathway   • biological regulation   • response to oxygen-containing compound   • response to nitrogen compound   • adenylate cyclase-activating G protein-coupled receptor signaling pathway   • cellular response to oxygen-containing compound   • cellular response to chemical stimulus   • cellular response to monoamine stimulus   • response to chemical   • adenylate cyclase-modulating G protein-coupled receptor signaling pathway   • G protein-coupled receptor signaling pathway   • response to ketone   • response to prostaglandin   • response to lipid   • response to endogenous stimulus   • response to alcohol   • cellular response to prostaglandin stimulus   • cellular response to endogenous stimulus   • cellular response to prostaglandin E stimulus   • cellular response to alcohol   • response to hormone   • cellular response to lipid   • response to prostaglandin E   • cellular response to ketone   • cellular response to hormone stimulus   • extrinsic component of plasma membrane   • catalytic complex   • plasma membrane protein complex   • cytoplasmic side of membrane   • membrane protein complex   • heterotrimeric G-protein complex   • side of membrane   • cytoplasmic side of plasma membrane   • GTPase complex   • extrinsic component of membrane   • extrinsic component of cytoplasmic side of plasma membrane   • extracellular exosome   • extracellular vesicle   • extracellular organelle   • extracellular region   • extracellular space   • extracellular membrane-bounded organelle   • synapse   • cell junction   • enzyme binding   • GTPase binding   • protein-containing complex binding   • pyrophosphatase activity   • GTPase activity   • ribonucleoside triphosphate phosphatase activity   • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides   • hydrolase activity   • hydrolase activity, acting on acid anhydrides   • catalytic activity   • signaling receptor complex adaptor activity   • protein-macromolecule adaptor activity   • molecular adaptor activity   • signaling adaptor activity   • multicellular organismal process   • system process   • sensory perception of chemical stimulus   • sensory perception   • nervous system process   • sensory perception of taste   • developmental process   • sensory organ development   • eye development   • animal organ development   • retina development in camera-type eye   • visual system development   • multicellular organism development   • camera-type eye development   • anatomical structure development   • sensory system development   • system development   • small GTPase-mediated signal transduction   • Ras protein signal transduction   • intracellular signal transduction   • intracellular signaling cassette   • phospholipase C-activating G protein-coupled receptor signaling pathway   • synaptic signaling   • cellular response to acetylcholine   • cell-cell signaling   • acetylcholine receptor signaling pathway   • postsynaptic signal transduction   • G protein-coupled acetylcholine receptor signaling pathway   • response to acetylcholine   • non-motile cilium   • 9+0 non-motile cilium   • neuron projection   • photoreceptor disc membrane   • photoreceptor outer segment   • photoreceptor cell cilium   • cytosol   • vacuolar membrane   • lytic vacuole membrane   • lysosomal membrane   • guanyl nucleotide binding   • GTP binding   • nucleotide binding   • guanyl ribonucleotide binding   • purine ribonucleotide binding   • purine ribonucleoside triphosphate binding   • nucleoside phosphate binding   • ion binding   • purine nucleotide binding   • anion binding   • heterocyclic compound binding   • carbohydrate derivative binding   • ribonucleotide binding   • small molecule binding   • D1 dopamine receptor binding   • signaling receptor binding   • G protein-coupled receptor binding   • dopamine receptor binding   • G-protein beta/gamma-subunit complex binding   • G protein activity   • molecular function regulator activity   • enzyme regulator activity   • cyclase regulator activity   • enzyme activator activity   • cyclase activator activity   • molecular function activator activity   • adenylate cyclase regulator activity   • adenylate cyclase activator activity   • cation binding   • metal ion binding   • epithelium development   • ectodermal placode morphogenesis   • epidermis development   • molting cycle process   • hair cycle   • hair follicle placode formation   • tissue development   • ectodermal placode formation   • anatomical structure morphogenesis   • skin development   • skin epidermis development   • hair follicle development   • molting cycle   • anatomical structure formation involved in morphogenesis   • ectodermal placode development   • hair cycle process   • cellular homeostasis   • chemical homeostasis   • homeostatic process   • glucose homeostasis   • carbohydrate homeostasis   • intracellular chemical homeostasis   • intracellular glucose homeostasis   • neuromuscular process   • regulation of system process   • skeletal muscle contraction   • muscle contraction   • muscle system process   • regulation of muscle system process   • striated muscle contraction   • multicellular organismal movement   • musculoskeletal movement   • regulation of striated muscle contraction   • regulation of muscle contraction   • regulation of skeletal muscle contraction   • regulation of multicellular organismal process   • sensory perception of smell   • response to peptide hormone   • cellular response to peptide hormone stimulus   • response to glucagon   • cellular response to glucagon stimulus   • skeletal system development   • bone development   • response to pH   • cellular response to pH   • response to abiotic stimulus   • cellular response to acidic pH   • response to acidic pH   • cellular response to abiotic stimulus   • cellular response to environmental stimulus   • regulation of body fluid levels   • wound healing   • homotypic cell-cell adhesion   • cell activation   • hemostasis   • platelet aggregation   • blood coagulation   • cell adhesion   • cell-cell adhesion   • response to stress   • coagulation   • regulation of biological quality   • response to wounding   • platelet activation   • response to fluid shear stress   • vascular endothelial cell response to laminar fluid shear stress   • response to laminar fluid shear stress   • cellular response to stress   • cellular response to laminar fluid shear stress   • vascular endothelial cell response to fluid shear stress   • cellular response to fluid shear stress   • cognition   • developmental growth   • growth   • positive regulation of biological process   • adaptive thermogenesis   • multicellular organismal-level homeostasis   • regulation of cold-induced thermogenesis   • cold-induced thermogenesis   • temperature homeostasis   • positive regulation of cold-induced thermogenesis   • positive regulation of multicellular organismal process   • positive regulation of cell communication   • regulation of localization   • establishment of protein localization   • nitrogen compound transport   • positive regulation of establishment of protein localization   • localization   • establishment of localization in cell   • positive regulation of insulin secretion involved in cellular response to glucose stimulus   • positive regulation of insulin secretion   • intracellular protein localization   • regulation of peptide hormone secretion   • regulation of hormone levels   • positive regulation of peptide hormone secretion   • establishment of protein localization to extracellular region   • protein secretion   • establishment of localization   • regulation of protein secretion   • regulation of secretion   • cellular response to carbohydrate stimulus   • response to glucose   • positive regulation of protein localization   • insulin secretion involved in cellular response to glucose stimulus   • cellular localization   • regulation of hormone secretion   • regulation of protein localization   • regulation of peptide secretion   • transport   • positive regulation of secretion by cell   • hormone secretion   • protein localization to extracellular region   • positive regulation of protein transport   • peptide secretion   • regulation of secretion by cell   • secretion by cell   • positive regulation of hormone secretion   • response to monosaccharide   • response to carbohydrate   • positive regulation of secretion   • signal release   • cellular response to hexose stimulus   • cellular response to monosaccharide stimulus   • positive regulation of cellular process   • positive regulation of peptide secretion   • regulation of signaling   • regulation of transport   • secretion   • regulation of peptide transport   • regulation of establishment of protein localization   • export from cell   • cellular response to glucose stimulus   • regulation of protein transport   • positive regulation of protein secretion   • peptide transport   • response to hexose   • positive regulation of transport   • regulation of cellular localization   • protein transport   • regulation of insulin secretion   • peptide hormone secretion   • macromolecule localization   • regulation of insulin secretion involved in cellular response to glucose stimulus   • hormone transport   • regulation of cell communication   • insulin secretion   • positive regulation of signaling   • adenylate cyclase-activating adrenergic receptor signaling pathway   • adrenergic receptor signaling pathway   • serotonin receptor signaling pathway   • adenylate cyclase-activating serotonin receptor signaling pathway   • intracellular transport   • regulation of defense response   • regulation of response to external stimulus   • negative regulation of inflammatory response   • negative regulation of biological process   • inflammatory response to antigenic stimulus   • regulation of response to stress   • regulation of immune system process   • negative regulation of inflammatory response to antigenic stimulus   • defense response   • immune response   • negative regulation of response to stimulus   • negative regulation of immune response   • regulation of inflammatory response to antigenic stimulus   • response to external stimulus   • regulation of inflammatory response   • regulation of response to stimulus   • negative regulation of immune system process   • immune system process   • negative regulation of response to external stimulus   • negative regulation of defense response   • regulation of immune response   • inflammatory response   • positive regulation of adenylate cyclase activity   • positive regulation of molecular function   • regulation of molecular function   • positive regulation of cyclase activity   • activation of adenylate cyclase activity   • regulation of adenylate cyclase activity   • regulation of catalytic activity   • positive regulation of catalytic activity   • positive regulation of lyase activity   • cell surface receptor signaling pathway   • bile acid signaling pathway   • adenylate cyclase-activating G protein-coupled bile acid receptor signaling pathway   • renal system process   • multicellular organismal-level water homeostasis   • multicellular organismal-level chemical homeostasis   • renal water homeostasis   • Golgi apparatus subcompartment   • organelle subcompartment   • trans-Golgi network membrane   • trans-Golgi network
SCOP2Domain Identifier• G protein-coupled receptor-like   • Transducin (heterotrimeric G protein), gamma chain
SCOP2Family Identifier• G protein-coupled receptor-like   • Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations-• Orientations of Proteins in Membranes database (OPM)   • Protein Data Bank of Transmembrane Proteins (PDBTM)   • MemProtMD


Details about the values in these tables can be found in the corresponding documentation page .
CodeG1I
PDB ResiduesL:L:?1
Environment DetailsOpen EMBL-EBI Page
CodeG1I
Name(5R,6R)-6-(methylamino)-5,6,7,8-tetrahydronaphthalene-1,2,5-triol
Synonyms
Identifier
FormulaC11 H15 N O3
Molecular Weight209.242
SMILES
PubChem12353638
Formal Charge0
Total Atoms30
Total Chiral Atoms2
Total Bonds31
Total Aromatic Bonds6

CodeGTP
PDB ResiduesO:O:?1
Environment DetailsOpen EMBL-EBI Page
CodeGTP
NameGuanosine-5'-Triphosphate
SynonymsGuanosine-5'-Triphosphate
Identifier
FormulaC10 H16 N5 O14 P3
Molecular Weight523.18
SMILES
PubChem5280317
Formal Charge0
Total Atoms48
Total Chiral Atoms4
Total Bonds50
Total Aromatic Bonds5

PDBsumOpen PDBsum Page
ChainR
ProteinReceptor
UniProtP07550
Sequence
>8GG2_nogp_Chain_R
WVVGMGIVM SLIVLAIVF GNVLVITAI AKFERLQTV TNYFITSLA 
CADLVMGLA VVPFGAAHI LTKTWTFGN FWCEFWTSI DVLCVTASI 
ETLCVIAVD RYFAITSPF KYQSLLTKN KARVIILMV WIVSGLTSF 
LPIQMHWYR ATHQEAINC YAEETCCDF FTNQAYAIA SSIVSFYVP 
LVIMVFVYS RVFQEAKRQ LQKIDKSEG RFHEHKALK TLGIIMGTF 
TLCWLPFFI VNIVHVIQD NLIRKEVYI LLNWIGYVN SGFNPLIYC 
RSPDFRIAF QEL


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  




This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
2RH1AAmineAdrenergicβ2Homo sapiensCarazolol--2.42007-10-30doi.org/10.1126/science.1150577
2R4RAAmineAdrenergicβ2Homo sapiens---3.42007-11-06doi.org/10.1038/nature06325
2R4SAAmineAdrenergicβ2Homo sapiens---3.42007-11-06doi.org/10.1038/nature06325
3D4SAAmineAdrenergicβ2Homo sapiensTimolol--2.82008-06-17doi.org/10.1016/j.str.2008.05.001
3KJ6AAmineAdrenergicβ2Homo sapiens---3.42010-02-16doi.org/10.1038/nature08650
3NY8AAmineAdrenergicβ2Homo sapiensICI118-551--2.842010-08-11doi.org/10.1021/ja105108q
3NY9AAmineAdrenergicβ2Homo sapiensPubChem 913103--2.842010-08-11doi.org/10.1021/ja105108q
3NYAAAmineAdrenergicβ2Homo sapiensAlprenolol--3.162010-08-11doi.org/10.1021/ja105108q
3PDSAAmineAdrenergicβ2Homo sapiensFAUC50--3.52011-01-12doi.org/10.1038/nature09665
3P0GAAmineAdrenergicβ2Homo sapiensBI167107--3.52011-01-19doi.org/10.1038/nature09648
3SN6AAmineAdrenergicβ2Homo sapiensBI167107-Gs/β1/γ23.22011-07-20doi.org/10.1038/nature10361
3SN6 (No Gprot) AAmineAdrenergicβ2Homo sapiensBI167107-3.22011-07-20doi.org/10.1038/nature10361
4GBRAAmineAdrenergicβ2Homo sapiensCarazolol--3.992012-10-24doi.org/10.1371/journal.pone.0046039
4LDEAAmineAdrenergicβ2Homo sapiensBI167107--2.792013-09-25doi.org/10.1038/nature12572
4LDLAAmineAdrenergicβ2Homo sapiensHydroxybenzyl Isoproterenol--3.12013-09-25doi.org/10.1038/nature12572
4LDOAAmineAdrenergicβ2Homo sapiensEpinephrine--3.22013-09-25doi.org/10.1038/nature12572
4QKXAAmineAdrenergicβ2Homo sapiensPubChem 76210628--3.32014-07-23doi.org/10.1073/pnas.1410415111
5D5AAAmineAdrenergicβ2Homo sapiensCarazolol--2.482016-01-13doi.org/10.1107/S2059798315021683
5D5BAAmineAdrenergicβ2Homo sapiensCarazolol--3.82016-01-13doi.org/10.1107/S2059798315021683
5JQHAAmineAdrenergicβ2Homo sapiensCarazolol--3.22016-07-13doi.org/10.1038/nature18636
5D6LAAmineAdrenergicβ2Homo sapiensCarazolol--3.22016-08-17doi.org/10.1038/nprot.2017.057
5X7DAAmineAdrenergicβ2Homo sapiensCarazololPubChem 129318963-2.72017-08-16doi.org/10.1038/nature23652
6MXTAAmineAdrenergicβ2Homo sapiensSalmeterol--2.962018-11-14doi.org/10.1038/s41589-018-0145-x
6E67AAmineAdrenergicβ2Homo sapiensBI167107-Gs(CT)3.72019-06-05doi.org/10.1016/j.cell.2019.04.021
6E67 (No Gprot) AAmineAdrenergicβ2Homo sapiensBI167107-3.72019-06-05doi.org/10.1016/j.cell.2019.04.021
6N48AAmineAdrenergicβ2Homo sapiensBI167107PubChem 138454256-3.22019-06-26doi.org/10.1126/science.aaw8981
6PRZAAmineAdrenergicβ2Homo sapiensAlprenolol--2.82019-11-13doi.org/10.1107/S2052252519013137
6PS0AAmineAdrenergicβ2Homo sapiensCarazolol--3.42019-11-13doi.org/10.1107/S2052252519013137
6PS1AAmineAdrenergicβ2Homo sapiensTimolol--3.22019-11-13doi.org/10.1107/S2052252519013137
6PS2AAmineAdrenergicβ2Homo sapiensAlprenolol--2.42019-11-13doi.org/10.1107/S2052252519013137
6PS3AAmineAdrenergicβ2Homo sapiensCarvedilol--2.52019-11-13doi.org/10.1107/S2052252519013137
6PS4AAmineAdrenergicβ2Homo sapiensICI118-551--2.62019-11-13doi.org/10.1107/S2052252519013137
6PS5AAmineAdrenergicβ2Homo sapiensPropranolol--2.92019-11-13doi.org/10.1107/S2052252519013137
6PS6AAmineAdrenergicβ2Homo sapiensTimolol--2.72019-11-13doi.org/10.1107/S2052252519013137
6NI3AAmineAdrenergicβ2Homo sapiensBI167107-Gs/β1/γ23.82019-11-20doi.org/10.1038/s41594-019-0330-y
6NI3 (No Gprot) AAmineAdrenergicβ2Homo sapiensBI167107-3.82019-11-20doi.org/10.1038/s41594-019-0330-y
6OBAAAmineAdrenergicβ2Homo sapiensAlprenololGTPL11074-3.12020-03-25doi.org/10.1038/s41589-020-0549-2
7BZ2AAmineAdrenergicβ2Homo sapiensArformoterol-Gs/β1/γ23.822020-08-05doi.org/10.1038/s41421-020-0176-9
7BZ2 (No Gprot) AAmineAdrenergicβ2Homo sapiensArformoterol-3.822020-08-05doi.org/10.1038/s41421-020-0176-9
7DHIAAmineAdrenergicβ2Homo sapiensSalbutamol-Gs/β1/γ23.262020-12-16doi.org/10.1093/nsr/nwaa284
7DHI (No Gprot) AAmineAdrenergicβ2Homo sapiensSalbutamol-3.262020-12-16doi.org/10.1093/nsr/nwaa284
7DHRAAmineAdrenergicβ2Homo sapiensIsoprenaline-Gs/β1/γ23.82020-12-16doi.org/10.1093/nsr/nwaa284
7DHR (No Gprot) AAmineAdrenergicβ2Homo sapiensIsoprenaline-3.82020-12-16doi.org/10.1093/nsr/nwaa284
7XKAAAmineAdrenergicβ2Homo sapiensConstrained Epinephrine--3.12023-04-26doi.org/10.1038/s41467-023-37808-y
8JJ8AAmineAdrenergicβ2Homo sapiensArformoterol--3.22023-09-06doi.org/10.1038/s41589-023-01389-0
8JJLAAmineAdrenergicβ2Homo sapiensOlodaterol--3.22023-09-06doi.org/10.1038/s41589-023-01389-0
8JJOAAmineAdrenergicβ2Homo sapiensAlprenolol--3.42023-09-06doi.org/10.1038/s41589-023-01389-0
8GE2AAmineAdrenergicβ2Homo sapiensConstrained Epinephrine-Gs/β1/γ13.32024-03-06doi.org/10.1038/s41586-024-07153-1
8GE2 (No Gprot) AAmineAdrenergicβ2Homo sapiensConstrained Epinephrine-3.32024-03-06doi.org/10.1038/s41586-024-07153-1
8GE5AAmineAdrenergicβ2Homo sapiensConstrained Epinephrine-Gs/β1/γ13.22024-03-06doi.org/10.1038/s41586-024-07153-1
8GE5 (No Gprot) AAmineAdrenergicβ2Homo sapiensConstrained Epinephrine-3.22024-03-06doi.org/10.1038/s41586-024-07153-1
9CHUAAmineAdrenergicβ2Homo sapiensNorepinephrine--3.492024-11-13doi.org/10.1073/pnas.2414544121
9CHVAAmineAdrenergicβ2Homo sapiens---3.952024-11-13doi.org/10.1073/pnas.2414544121
9U9VAAmineAdrenergicβ2Homo sapiensMETH-Gs/β1/γ22.852025-09-03To be published
9U9V (No Gprot) AAmineAdrenergicβ2Homo sapiensMETH-2.852025-09-03To be published
7XK9AAmineAdrenergicβ2Homo sapiensConstrained IsoproterenolNa-3.42023-04-26doi.org/10.1038/s41467-023-37808-y
8GDZAAmineAdrenergicβ2Homo sapiensConstrained Epinephrine-Gs/β1/γ23.52024-03-06doi.org/10.1038/s41586-024-07153-1
8GDZ (No Gprot) AAmineAdrenergicβ2Homo sapiensConstrained Epinephrine-3.52024-03-06doi.org/10.1038/s41586-024-07153-1
8GE1AAmineAdrenergicβ2Homo sapiensConstrained Epinephrine-Gs/β1/γ23.42024-03-06doi.org/10.1038/s41586-024-07153-1
8GE1 (No Gprot) AAmineAdrenergicβ2Homo sapiensConstrained Epinephrine-3.42024-03-06doi.org/10.1038/s41586-024-07153-1
8GE3AAmineAdrenergicβ2Homo sapiensConstrained Epinephrine-Gs/β1/γ23.32024-03-06doi.org/10.1038/s41586-024-07153-1
8GE3 (No Gprot) AAmineAdrenergicβ2Homo sapiensConstrained Epinephrine-3.32024-03-06doi.org/10.1038/s41586-024-07153-1
8GE4AAmineAdrenergicβ2Homo sapiensConstrained Epinephrine-Gs/β1/γ23.32024-03-06doi.org/10.1038/s41586-024-07153-1
8GE4 (No Gprot) AAmineAdrenergicβ2Homo sapiensConstrained Epinephrine-3.32024-03-06doi.org/10.1038/s41586-024-07153-1
8GE6AAmineAdrenergicβ2Homo sapiensConstrained Epinephrine-Gs/β1/γ23.42024-03-06doi.org/10.1038/s41586-024-07153-1
8GE6 (No Gprot) AAmineAdrenergicβ2Homo sapiensConstrained Epinephrine-3.42024-03-06doi.org/10.1038/s41586-024-07153-1
8GE7AAmineAdrenergicβ2Homo sapiensConstrained Epinephrine-Gs/β1/γ23.42024-03-06doi.org/10.1038/s41586-024-07153-1
8GE7 (No Gprot) AAmineAdrenergicβ2Homo sapiensConstrained Epinephrine-3.42024-03-06doi.org/10.1038/s41586-024-07153-1
8GE8AAmineAdrenergicβ2Homo sapiensConstrained Epinephrine-Gs/β1/γ23.42024-03-06doi.org/10.1038/s41586-024-07153-1
8GE8 (No Gprot) AAmineAdrenergicβ2Homo sapiensConstrained Epinephrine-3.42024-03-06doi.org/10.1038/s41586-024-07153-1
8GE9AAmineAdrenergicβ2Homo sapiensConstrained Epinephrine-Gs/β1/γ23.52024-03-06doi.org/10.1038/s41586-024-07153-1
8GE9 (No Gprot) AAmineAdrenergicβ2Homo sapiensConstrained Epinephrine-3.52024-03-06doi.org/10.1038/s41586-024-07153-1
8GEAAAmineAdrenergicβ2Homo sapiensConstrained Epinephrine-Gs/β1/γ23.52024-03-06doi.org/10.1038/s41586-024-07153-1
8GEA (No Gprot) AAmineAdrenergicβ2Homo sapiensConstrained Epinephrine-3.52024-03-06doi.org/10.1038/s41586-024-07153-1
8GEBAAmineAdrenergicβ2Homo sapiensConstrained Epinephrine-Gs/β1/γ23.62024-03-06doi.org/10.1038/s41586-024-07153-1
8GEB (No Gprot) AAmineAdrenergicβ2Homo sapiensConstrained Epinephrine-3.62024-03-06doi.org/10.1038/s41586-024-07153-1
8GECAAmineAdrenergicβ2Homo sapiensConstrained Epinephrine-Gs/β1/γ23.52024-03-06doi.org/10.1038/s41586-024-07153-1
8GEC (No Gprot) AAmineAdrenergicβ2Homo sapiensConstrained Epinephrine-3.52024-03-06doi.org/10.1038/s41586-024-07153-1
8GEDAAmineAdrenergicβ2Homo sapiensConstrained Epinephrine-Gs/β1/γ23.52024-03-06doi.org/10.1038/s41586-024-07153-1
8GED (No Gprot) AAmineAdrenergicβ2Homo sapiensConstrained Epinephrine-3.52024-03-06doi.org/10.1038/s41586-024-07153-1
8GEEAAmineAdrenergicβ2Homo sapiensConstrained Epinephrine-Gs/β1/γ23.72024-03-06doi.org/10.1038/s41586-024-07153-1
8GEE (No Gprot) AAmineAdrenergicβ2Homo sapiensConstrained Epinephrine-3.72024-03-06doi.org/10.1038/s41586-024-07153-1
8GEFAAmineAdrenergicβ2Homo sapiensConstrained Epinephrine-Gs/β1/γ23.82024-03-06doi.org/10.1038/s41586-024-07153-1
8GEF (No Gprot) AAmineAdrenergicβ2Homo sapiensConstrained Epinephrine-3.82024-03-06doi.org/10.1038/s41586-024-07153-1
8GEGAAmineAdrenergicβ2Homo sapiensConstrained Epinephrine-Gs/β1/γ23.82024-03-06doi.org/10.1038/s41586-024-07153-1
8GEG (No Gprot) AAmineAdrenergicβ2Homo sapiensConstrained Epinephrine-3.82024-03-06doi.org/10.1038/s41586-024-07153-1
8GEHAAmineAdrenergicβ2Homo sapiensConstrained Epinephrine-Gs/β1/γ242024-03-06doi.org/10.1038/s41586-024-07153-1
8GEH (No Gprot) AAmineAdrenergicβ2Homo sapiensConstrained Epinephrine-42024-03-06doi.org/10.1038/s41586-024-07153-1
8GEIAAmineAdrenergicβ2Homo sapiensConstrained Epinephrine-Gs/β1/γ24.12024-03-06doi.org/10.1038/s41586-024-07153-1
8GEI (No Gprot) AAmineAdrenergicβ2Homo sapiensConstrained Epinephrine-4.12024-03-06doi.org/10.1038/s41586-024-07153-1
8GEJAAmineAdrenergicβ2Homo sapiensConstrained Epinephrine-Gs/β1/γ24.22024-03-06doi.org/10.1038/s41586-024-07153-1
8GEJ (No Gprot) AAmineAdrenergicβ2Homo sapiensConstrained Epinephrine-4.22024-03-06doi.org/10.1038/s41586-024-07153-1
8GFVAAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTPGs/β1/γ23.12024-03-06doi.org/10.1038/s41586-024-07153-1
8GFV (No Gprot) AAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTP3.12024-03-06doi.org/10.1038/s41586-024-07153-1
8GFWAAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTPGs/β1/γ232024-03-06doi.org/10.1038/s41586-024-07153-1
8GFW (No Gprot) AAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTP32024-03-06doi.org/10.1038/s41586-024-07153-1
8GFXAAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTPGs/β1/γ232024-03-06doi.org/10.1038/s41586-024-07153-1
8GFX (No Gprot) AAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTP32024-03-06doi.org/10.1038/s41586-024-07153-1
8GFYAAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTPGs/β1/γ232024-03-06doi.org/10.1038/s41586-024-07153-1
8GFY (No Gprot) AAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTP32024-03-06doi.org/10.1038/s41586-024-07153-1
8GFZAAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTPGs/β1/γ232024-03-06doi.org/10.1038/s41586-024-07153-1
8GFZ (No Gprot) AAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTP32024-03-06doi.org/10.1038/s41586-024-07153-1
8GG0AAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTPGs/β1/γ22.92024-03-06doi.org/10.1038/s41586-024-07153-1
8GG0 (No Gprot) AAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTP2.92024-03-06doi.org/10.1038/s41586-024-07153-1
8GG1AAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTPGs/β1/γ232024-03-06doi.org/10.1038/s41586-024-07153-1
8GG1 (No Gprot) AAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTP32024-03-06doi.org/10.1038/s41586-024-07153-1
8GG2AAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTPGs/β1/γ232024-03-06doi.org/10.1038/s41586-024-07153-1
8GG2 (No Gprot) AAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTP32024-03-06doi.org/10.1038/s41586-024-07153-1
8GG3AAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTPGs/β1/γ23.12024-03-06doi.org/10.1038/s41586-024-07153-1
8GG3 (No Gprot) AAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTP3.12024-03-06doi.org/10.1038/s41586-024-07153-1
8GG4AAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTPGs/β1/γ23.22024-03-06doi.org/10.1038/s41586-024-07153-1
8GG4 (No Gprot) AAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTP3.22024-03-06doi.org/10.1038/s41586-024-07153-1
8GG5AAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTPGs/β1/γ23.22024-03-06doi.org/10.1038/s41586-024-07153-1
8GG5 (No Gprot) AAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTP3.22024-03-06doi.org/10.1038/s41586-024-07153-1
8GG6AAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTPGs/β1/γ23.32024-03-06doi.org/10.1038/s41586-024-07153-1
8GG6 (No Gprot) AAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTP3.32024-03-06doi.org/10.1038/s41586-024-07153-1
8GG7AAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTPGs/β1/γ23.32024-03-06doi.org/10.1038/s41586-024-07153-1
8GG7 (No Gprot) AAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTP3.32024-03-06doi.org/10.1038/s41586-024-07153-1
8GG8AAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTPGs/β1/γ23.32024-03-06doi.org/10.1038/s41586-024-07153-1
8GG8 (No Gprot) AAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTP3.32024-03-06doi.org/10.1038/s41586-024-07153-1
8GG9AAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTPGs/β1/γ23.42024-03-06doi.org/10.1038/s41586-024-07153-1
8GG9 (No Gprot) AAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTP3.42024-03-06doi.org/10.1038/s41586-024-07153-1
8GGAAAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTPGs/β1/γ23.52024-03-06doi.org/10.1038/s41586-024-07153-1
8GGA (No Gprot) AAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTP3.52024-03-06doi.org/10.1038/s41586-024-07153-1
8GGBAAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTPGs/β1/γ23.52024-03-06doi.org/10.1038/s41586-024-07153-1
8GGB (No Gprot) AAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTP3.52024-03-06doi.org/10.1038/s41586-024-07153-1
8GGCAAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTPGs/β1/γ23.42024-03-06doi.org/10.1038/s41586-024-07153-1
8GGC (No Gprot) AAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTP3.42024-03-06doi.org/10.1038/s41586-024-07153-1
8GGEAAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTPGs/β1/γ23.52024-03-06doi.org/10.1038/s41586-024-07153-1
8GGE (No Gprot) AAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTP3.52024-03-06doi.org/10.1038/s41586-024-07153-1
8GGFAAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTPGs/β1/γ23.62024-03-06doi.org/10.1038/s41586-024-07153-1
8GGF (No Gprot) AAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTP3.62024-03-06doi.org/10.1038/s41586-024-07153-1
8GGIAAmineAdrenergicβ2Homo sapiensConstrained Epinephrine--3.52024-03-06doi.org/10.1038/s41586-024-07153-1
8GGJAAmineAdrenergicβ2Homo sapiensConstrained Epinephrine--3.52024-03-06doi.org/10.1038/s41586-024-07153-1
8GGKAAmineAdrenergicβ2Homo sapiensConstrained Epinephrine--3.32024-03-06doi.org/10.1038/s41586-024-07153-1
8GGLAAmineAdrenergicβ2Homo sapiensConstrained Epinephrine--3.22024-03-06doi.org/10.1038/s41586-024-07153-1
8GGMAAmineAdrenergicβ2Homo sapiensConstrained Epinephrine--3.22024-03-06doi.org/10.1038/s41586-024-07153-1
8GGNAAmineAdrenergicβ2Homo sapiensConstrained Epinephrine--3.32024-03-06doi.org/10.1038/s41586-024-07153-1
8GGOAAmineAdrenergicβ2Homo sapiensConstrained Epinephrine--3.22024-03-06doi.org/10.1038/s41586-024-07153-1
8GGPAAmineAdrenergicβ2Homo sapiensConstrained Epinephrine--3.22024-03-06doi.org/10.1038/s41586-024-07153-1
8GGQAAmineAdrenergicβ2Homo sapiensConstrained Epinephrine--3.42024-03-06doi.org/10.1038/s41586-024-07153-1
8GGRAAmineAdrenergicβ2Homo sapiensConstrained Epinephrine--3.42024-03-06doi.org/10.1038/s41586-024-07153-1
8GGSAAmineAdrenergicβ2Homo sapiensConstrained Epinephrine--3.52024-03-06doi.org/10.1038/s41586-024-07153-1
8GGTAAmineAdrenergicβ2Homo sapiensConstrained Epinephrine--3.52024-03-06doi.org/10.1038/s41586-024-07153-1
8GGUAAmineAdrenergicβ2Homo sapiensConstrained Epinephrine--3.42024-03-06doi.org/10.1038/s41586-024-07153-1
8GGVAAmineAdrenergicβ2Homo sapiensConstrained Epinephrine--3.52024-03-06doi.org/10.1038/s41586-024-07153-1
8GGWAAmineAdrenergicβ2Homo sapiensConstrained Epinephrine--3.62024-03-06doi.org/10.1038/s41586-024-07153-1
8GGXAAmineAdrenergicβ2Homo sapiensConstrained Epinephrine--3.62024-03-06doi.org/10.1038/s41586-024-07153-1
8GGYAAmineAdrenergicβ2Homo sapiensConstrained Epinephrine--3.92024-03-06doi.org/10.1038/s41586-024-07153-1
8GGZAAmineAdrenergicβ2Homo sapiensConstrained Epinephrine--3.92024-03-06doi.org/10.1038/s41586-024-07153-1
8GH0AAmineAdrenergicβ2Homo sapiensConstrained Epinephrine--42024-03-06doi.org/10.1038/s41586-024-07153-1
8GH1AAmineAdrenergicβ2Homo sapiensConstrained Epinephrine--4.12024-03-06doi.org/10.1038/s41586-024-07153-1
8UNLAAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTPGs/β1/γ23.32024-03-06doi.org/10.1038/s41586-024-07153-1
8UNL (No Gprot) AAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTP3.32024-03-06doi.org/10.1038/s41586-024-07153-1
8UNMAAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTPGs/β1/γ23.42024-03-06doi.org/10.1038/s41586-024-07153-1
8UNM (No Gprot) AAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTP3.42024-03-06doi.org/10.1038/s41586-024-07153-1
8UNNAAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTPGs/β1/γ23.42024-03-06doi.org/10.1038/s41586-024-07153-1
8UNN (No Gprot) AAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTP3.42024-03-06doi.org/10.1038/s41586-024-07153-1
8UNOAAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTPGs/β1/γ23.32024-03-06doi.org/10.1038/s41586-024-07153-1
8UNO (No Gprot) AAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTP3.32024-03-06doi.org/10.1038/s41586-024-07153-1
8UNPAAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTPGs/β1/γ23.32024-03-06doi.org/10.1038/s41586-024-07153-1
8UNP (No Gprot) AAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTP3.32024-03-06doi.org/10.1038/s41586-024-07153-1
8UNQAAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTPGs/β1/γ23.32024-03-06doi.org/10.1038/s41586-024-07153-1
8UNQ (No Gprot) AAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTP3.32024-03-06doi.org/10.1038/s41586-024-07153-1
8UNRAAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTPGs/β1/γ23.42024-03-06doi.org/10.1038/s41586-024-07153-1
8UNR (No Gprot) AAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTP3.42024-03-06doi.org/10.1038/s41586-024-07153-1
8UNSAAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTPGs/β1/γ23.42024-03-06doi.org/10.1038/s41586-024-07153-1
8UNS (No Gprot) AAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTP3.42024-03-06doi.org/10.1038/s41586-024-07153-1
8UNTAAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTPGs/β1/γ23.42024-03-06doi.org/10.1038/s41586-024-07153-1
8UNT (No Gprot) AAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTP3.42024-03-06doi.org/10.1038/s41586-024-07153-1
8UNUAAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTPGs/β1/γ23.52024-03-06doi.org/10.1038/s41586-024-07153-1
8UNU (No Gprot) AAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTP3.52024-03-06doi.org/10.1038/s41586-024-07153-1
8UNVAAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTPGs/β1/γ23.32024-03-06doi.org/10.1038/s41586-024-07153-1
8UNV (No Gprot) AAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTP3.32024-03-06doi.org/10.1038/s41586-024-07153-1
8UNWAAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTPGs/β1/γ23.42024-03-06doi.org/10.1038/s41586-024-07153-1
8UNW (No Gprot) AAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTP3.42024-03-06doi.org/10.1038/s41586-024-07153-1
8UNXAAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTPGs/β1/γ23.62024-03-06doi.org/10.1038/s41586-024-07153-1
8UNX (No Gprot) AAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTP3.62024-03-06doi.org/10.1038/s41586-024-07153-1
8UNYAAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTPGs/β1/γ23.62024-03-06doi.org/10.1038/s41586-024-07153-1
8UNY (No Gprot) AAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTP3.62024-03-06doi.org/10.1038/s41586-024-07153-1
8UNZAAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTPGs/β1/γ23.82024-03-06doi.org/10.1038/s41586-024-07153-1
8UNZ (No Gprot) AAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTP3.82024-03-06doi.org/10.1038/s41586-024-07153-1
8UO0AAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTPGs/β1/γ23.52024-03-06doi.org/10.1038/s41586-024-07153-1
8UO0 (No Gprot) AAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTP3.52024-03-06doi.org/10.1038/s41586-024-07153-1
8UO1AAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTP; MgGs/β1/γ23.62024-03-06doi.org/10.1038/s41586-024-07153-1
8UO1 (No Gprot) AAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTP; Mg3.62024-03-06doi.org/10.1038/s41586-024-07153-1
8UO2AAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTPGs/β1/γ23.62024-03-06doi.org/10.1038/s41586-024-07153-1
8UO2 (No Gprot) AAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTP3.62024-03-06doi.org/10.1038/s41586-024-07153-1
8UO3AAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTP; MgGs/β1/γ23.52024-03-06doi.org/10.1038/s41586-024-07153-1
8UO3 (No Gprot) AAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTP; Mg3.52024-03-06doi.org/10.1038/s41586-024-07153-1
8UO4AAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTP; MgGs/β1/γ242024-03-06doi.org/10.1038/s41586-024-07153-1
8UO4 (No Gprot) AAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTP; Mg42024-03-06doi.org/10.1038/s41586-024-07153-1
8W1VAAmineAdrenergicβ2Homo sapiensPubChem 171716265--32024-07-17doi.org/10.1021/acs.jmedchem.4c00578
9CHXAAmineAdrenergicβ2Homo sapiensCarazolol--3.52024-11-13doi.org/10.1073/pnas.2414544121
9BUYAAmineAdrenergicβ2Homo sapiensLM189-Gi1/β1/γ22.92025-05-28doi.org/10.1126/sciadv.adq3971
9BUY (No Gprot) AAmineAdrenergicβ2Homo sapiensLM189-2.92025-05-28doi.org/10.1126/sciadv.adq3971
9M55AAmineAdrenergicOct-Beta2Ixodes scapularisDPMF-chim(NtGi1-Gs)/β1/γ23.392025-12-1710.1093/pnasnexus/pgaf376
9M55 (No Gprot) AAmineAdrenergicOct-Beta2Ixodes scapularisDPMF-3.392025-12-1710.1093/pnasnexus/pgaf376
9M57AAmineAdrenergicOct-Beta2Ixodes scapularisOctopamine-chim(NtGi1-Gs)/β1/γ23.652025-12-1710.1093/pnasnexus/pgaf376
9M57 (No Gprot) AAmineAdrenergicOct-Beta2Ixodes scapularisOctopamine-3.652025-12-1710.1093/pnasnexus/pgaf376
9L8LAAmineAdrenergicβ2Homo sapiensBI167107AtazanavirGs/β1/γ2 ; Arrestin23.222025-12-31To be published
9L8L (No Gprot) AAmineAdrenergicβ2Homo sapiensBI167107Atazanavir3.222025-12-31To be published




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