Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg Int. Strength Num Of Links Community ConSurf
1R:R:V33 3.0525404
2R:R:M40 5.5675436
3R:R:N51 4.765409
4R:R:N69 6.9525409
5R:R:F71 5.796508
6R:R:L80 4.6525447
7R:R:W99 9.57286717
8R:R:F101 7.962515
9R:R:W105 9.3425415
10R:R:W109 6.75515
11R:R:L124 4.375418
12R:R:D130 6.805408
13R:R:R131 5.4409
14R:R:Y174 10.1225475
15R:R:D192 6.98423
16R:R:F193 5.785404
17R:R:F194 5.6975421
18R:R:T195 5.7875473
19R:R:Y199 8.274576
20R:R:Y219 7.17667609
21R:R:E225 7.27465
22R:R:H269 7.815405
23R:R:F282 7.62419
24R:R:W286 8.66833618
25R:R:F289 9.736516
26R:R:F290 13.136517
27R:R:I303 8.4425403
28R:R:Y308 7.4725415
29R:R:N312 11.28415
30R:R:Y316 11.3825406
31R:R:N318 6.3419
32R:R:N322 5.57459
33R:R:Y326 7.36559
34R:R:F332 6.34509
35R:R:F336 6.9175407
36L:L:?3 9.96910
37W:W:?4 11.2314700
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
1R:R:M40 R:R:W313 10.06811.63YesNo365
2R:R:W313 R:R:Y316 12.263717.36NoYes056
3R:R:M82 R:R:S319 17.50227.67NoNo079
4R:R:M82 R:R:V86 18.46094.56NoNo077
5R:R:D113 R:R:V86 19.37597.3NoNo077
6R:R:D79 R:R:S319 17.30378.83NoNo099
7R:R:F332 R:R:F336 20.42177.5YesYes097
8R:R:F332 R:R:Y326 38.63564.13YesYes099
9R:R:N322 R:R:Y326 49.37915.81YesYes599
10R:R:L75 R:R:N322 46.31195.49NoYes099
11R:R:L124 R:R:L75 49.23874.15YesNo089
12R:R:F282 R:R:L124 98.47254.87YesYes198
13R:R:F282 R:R:W286 10012.03YesYes198
14R:R:N312 R:R:W286 39.93564.52YesYes158
15R:R:N312 R:R:Y316 11.665711.63YesYes056
16R:R:D79 R:R:N322 16.69136.73NoYes099
17R:R:F336 R:R:L53 16.180514.61YesNo076
18R:R:L124 R:R:M279 63.98364.24YesNo188
19R:R:M279 R:R:Y219 63.121810.78NoYes089
20R:R:L275 R:R:Y219 28.33285.86NoYes089
21R:R:I127 R:R:L275 27.18294.28NoNo098
22R:R:F71 R:R:I127 26.03066.28YesNo089
23R:R:D130 R:R:F71 18.15348.36YesYes088
24L:L:?3 R:R:W109 36.28513.43YesYes105
25L:L:?3 R:R:D113 22.476920.43YesNo007
26R:R:W109 R:R:W99 16.892214.99YesYes157
27L:L:?3 R:R:N312 35.868714.47YesYes105
28R:R:F101 R:R:T100 12.88829.08YesNo052
29R:R:F108 R:R:Q170 10.65633.51NoNo054
30R:R:E107 R:R:Q170 18.59897.65NoNo054
31R:R:E107 R:R:H172 20.86234.92NoNo054
32R:R:H172 R:R:R175 23.498523.7NoNo042
33R:R:R175 R:R:Y174 59.493116.46NoYes025
34R:R:T195 R:R:Y174 31.26924.99YesYes735
35R:R:F193 R:R:T195 38.73496.49YesYes043
36L:L:?3 R:R:F193 44.60057.33YesYes004
37R:R:Y174 R:R:Y199 30.69316.95YesYes756
38R:R:S203 R:R:Y199 40.35213.99NoYes056
39L:L:?3 R:R:S203 41.41956.78YesNo005
40L:L:?3 R:R:V114 15.773810.09YesNo005
41R:R:S165 R:R:V114 14.446.46NoNo075
42L:L:?3 R:R:V117 31.27657.85YesNo006
43R:R:V117 R:R:W286 31.213512.26NoYes068
44R:R:F282 R:R:I121 12.98027.54YesNo097
45R:R:I121 R:R:P211 11.806110.16NoNo078
46R:R:P211 W:W:?4 10.658713.55NoYes080
47R:R:E225 R:R:R221 11.196111.63YesNo055
48R:R:E225 R:R:I135 25.22454.1YesNo059
49R:R:I135 R:R:V222 26.38656.14NoNo098
50R:R:V222 R:R:Y219 27.54366.31NoYes089
51R:R:K140 R:R:Q229 10.898410.85NoNo057
52R:R:E225 R:R:Q229 12.09916.37YesNo657
53R:R:R175 R:R:Y185 33.980528.81NoNo021
54R:R:A181 R:R:Y185 31.38786.67NoNo041
55R:R:A181 R:R:F194 23.47194.16NoYes241
56R:R:D192 R:R:F194 18.24065.97YesYes231
57R:R:F208 R:R:F290 11.939337.51NoYes087
58R:R:F290 R:R:W286 40.0766.01YesYes178
59L:L:?3 R:R:F290 37.190412.84YesYes107
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


2D representation of the interactions of this orthosteric/allosteric ligand.


Links and nodes colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:D113 R:R:V86 7.3 0 No No 7 7 1 2
R:R:F89 R:R:W105 22.05 1 No Yes 5 5 2 2
R:R:F89 R:R:W109 5.01 1 No Yes 5 5 2 1
R:R:G90 R:R:W109 5.63 0 No Yes 7 5 2 1
R:R:W105 R:R:W99 5.62 1 Yes Yes 5 7 2 2
R:R:W109 R:R:W99 14.99 1 Yes Yes 5 7 1 2
R:R:W105 R:R:W109 4.69 1 Yes Yes 5 5 2 1
R:R:F193 R:R:T110 5.19 0 Yes No 4 4 1 2
R:R:D113 R:R:Y316 11.49 0 No Yes 7 6 1 2
L:L:?3 R:R:D113 20.43 1 Yes No 0 7 0 1
R:R:S165 R:R:V114 6.46 0 No No 7 5 2 1
L:L:?3 R:R:V114 10.09 1 Yes No 0 5 0 1
R:R:V117 R:R:W286 12.26 0 No Yes 6 8 1 2
L:L:?3 R:R:V117 7.85 1 Yes No 0 6 0 1
R:R:F193 R:R:T195 6.49 0 Yes Yes 4 3 1 2
R:R:F193 R:R:Y308 4.13 0 Yes Yes 4 5 1 2
L:L:?3 R:R:F193 7.33 1 Yes Yes 0 4 0 1
R:R:T195 R:R:Y199 9.99 7 Yes Yes 3 6 2 2
R:R:S203 R:R:Y199 13.99 0 No Yes 5 6 1 2
L:L:?3 R:R:S203 6.78 1 Yes No 0 5 0 1
R:R:F208 R:R:F290 37.51 0 No Yes 8 7 2 1
R:R:F290 R:R:W286 6.01 1 Yes Yes 7 8 1 2
R:R:N312 R:R:W286 4.52 1 Yes Yes 5 8 1 2
R:R:F289 R:R:F290 5.36 1 Yes Yes 6 7 1 1
R:R:F289 R:R:N293 12.08 1 Yes No 6 5 1 2
R:R:F289 R:R:Y308 10.32 1 Yes Yes 6 5 1 2
R:R:F289 R:R:N312 14.5 1 Yes Yes 6 5 1 1
L:L:?3 R:R:F289 6.42 1 Yes Yes 0 6 0 1
L:L:?3 R:R:F290 12.84 1 Yes Yes 0 7 0 1
R:R:N293 R:R:Y308 6.98 1 No Yes 5 5 2 2
R:R:N312 R:R:Y316 11.63 1 Yes Yes 5 6 1 2
L:L:?3 R:R:N312 14.47 1 Yes Yes 0 5 0 1
R:R:F290 R:R:S204 3.96 1 Yes No 7 5 1 2
L:L:?3 R:R:W109 3.43 1 Yes Yes 0 5 0 1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

ShowSimilarityNetwork TypeNameLigandDescription
100.00Consensusbeta2_off_alloOrthosteric Ligand6OBA-β2-(S)-Alprenolol-GTPL11074
88.89Single8GGSEpinephrine8GGS-β2-Epinephrine
88.89Single8UNVEpinephrine8UNV-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
81.82Single2Y04Salbutamol2Y04-β1-Salbutamol
81.82Single6H7MSalbutamol6H7M-β1-Salbutamol
81.82Single7S0GIsoprenaline7S0G-β1-Isoprenaline-chim(Gi1-CtGs)/&β;1/&γ;2
81.82Single7UM6Lisuride7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/&β;1/&γ;2
81.82Single7WC7Lisuride7WC7-5-HT2A-Lisuride
81.82Single7XJHIsoproterenol7XJH-β3-Isoproterenol-Gs/&β;1/&γ;2
80.00Single6KUXRS-799486KUX-α2a-RS-79948
80.00Single7YMHNorepinephrine7YMH-Alpha1A-Norepinephrine-chim(Gs-CtGq)/&β;1/&γ;2
80.00Single8GECEpinephrine8GEC-β2-Epinephrine-Gs/&β;1/&γ;2
80.00Single8GEFEpinephrine8GEF-β2-Epinephrine-Gs/&β;1/&γ;2
80.00Single8GG7Epinephrine8GG7-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
80.00Single8GGAEpinephrine8GGA-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
80.00Single8GGVEpinephrine8GGV-β2-Epinephrine
80.00Single8GGXEpinephrine8GGX-β2-Epinephrine
80.00Single8GH0Epinephrine8GH0-β2-Epinephrine
80.00Single8UNOEpinephrine8UNO-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
80.00Consensusalpha2a_offOrthosteric Ligand6KUX-α2a-RS-79948
77.78Single8GGREpinephrine8GGR-β2-Epinephrine
75.00Single2Y03Isoprenaline2Y03-β1-Isoprenaline
75.00Single5TVNLSD5TVN-5-HT2B-LSD
75.00Single6E67BI1671076E67-β2-BI167107-Gs (fused)
75.00Single6KUWPubChem 572132346KUW-α2c-PubChem 57213234
75.00Single6PS3(S)-Carvedilol6PS3-β2-(S)-Carvedilol
75.00Single7BVQ(S)-Carazolol7BVQ-β1-(S)-Carazolol
75.00Single7S0FIsoprenaline7S0F-β1-Isoprenaline-Gi1/&β;1/&γ;2
75.00Consensusadrenergic_offOrthosteric Ligandbeta_off alpha_off
75.00Consensusalpha2c_offOrthosteric Ligand6KUW-α2c-PubChem 57213234
75.00Consensusbeta2_onOrthosteric Ligand3SN6-β2-BI167107-Gs/&β;1/&γ;2 7DHR-β2-Isoprenaline-Gs/&β;1/&γ;2 7BZ2-β2-Arformoterol-Gs/&β;1/&γ;2 7DHI-β2-Salbutamol-Gs/&β;1/&γ;2
75.00Consensusbeta3_onOrthosteric Ligand7DH5-β3-Mirabegron-Gs/&β;1/&γ;2 7XJH-β3-Isoproterenol-Gs/&β;1/&γ;2
75.00Consensusbeta_onOrthosteric Ligandbeta1_on beta2_on beta3_on
75.00Consensusgi_adrenergicOrthosteric Ligand7S0F-β1-Isoprenaline-Gi1/&β;1/&γ;2 6K42-α2b-Dexmedetomidine-Gi1/&β;1/&γ;2
75.00Consensusgs_adrenergicOrthosteric Ligand3SN6-β2-BI167107-Gs/&β;1/&γ;2 7DHR-β2-Isoprenaline-Gs/&β;1/&γ;2 7DHI-β2-Salbutamol-Gs/&β;1/&γ;2 7XJH-β3-Isoproterenol-Gs/&β;1/&γ;2 7DH5-β3-Mirabegron-Gs/&β;1/&γ;2 7XJI-β3-Solabegron-Gs/&β;1/&γ;2 8THK-Alpha1A-A61603-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8THL-Alpha1A-Epinephrine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 7JJO-β1-Isoprenaline-Gs/&β;1/&γ;2 8DCR-β1-Dobutamine-Gs/&β;1/&γ;2 7BZ2-β2-Arformoterol-Gs/&β;1/&γ;2
72.73Single4LDOL-Epinephrine4LDO-β2-L-Epinephrine
72.73Single6PS4ICI 118-5516PS4-β2-ICI 118-551
72.73Single6PS5(S)-Propranolol6PS5-β2-(S)-Propranolol
72.73Single7DHISalbutamol7DHI-β2-Salbutamol-Gs/&β;1/&γ;2
72.73Single7UM7Methylergometrine7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/&β;1/&γ;2
72.73Single8GDZEpinephrine8GDZ-β2-Epinephrine-Gs/&β;1/&γ;2
72.73Single8GE1Epinephrine8GE1-β2-Epinephrine-Gs/&β;1/&γ;2
72.73Single8GE4Epinephrine8GE4-β2-Epinephrine-Gs/&β;1/&γ;2
72.73Single8GE6Epinephrine8GE6-β2-Epinephrine-Gs/&β;1/&γ;2
72.73Single8GE7Epinephrine8GE7-β2-Epinephrine-Gs/&β;1/&γ;2
72.73Single8GE8Epinephrine8GE8-β2-Epinephrine-Gs/&β;1/&γ;2
72.73Single8GE9Epinephrine8GE9-β2-Epinephrine-Gs/&β;1/&γ;2
72.73Single8GEGEpinephrine8GEG-β2-Epinephrine-Gs/&β;1/&γ;2
72.73Single8GFVEpinephrine8GFV-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
72.73Single8GG4Epinephrine8GG4-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
72.73Single8GGIEpinephrine8GGI-β2-Epinephrine
72.73Single8GGKEpinephrine8GGK-β2-Epinephrine
72.73Single8GGMEpinephrine8GGM-β2-Epinephrine
72.73Single8GGPEpinephrine8GGP-β2-Epinephrine
72.73Single8GGQEpinephrine8GGQ-β2-Epinephrine
72.73Single8GGTEpinephrine8GGT-β2-Epinephrine
72.73Single8UNQEpinephrine8UNQ-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
72.73Single8UNZEpinephrine8UNZ-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
72.73Consensus5ht5_onOrthosteric Ligand5ht5a_on
72.73Consensus5ht5a_onOrthosteric Ligand7UM5-5-HT5A-5-CT-chim(NtGi1-Go)/&β;1/&γ;2 7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/&β;1/&γ;2 7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/&β;1/&γ;2
70.00Single8GEIEpinephrine8GEI-β2-Epinephrine-Gs/&β;1/&γ;2
70.00Single8GGYEpinephrine8GGY-β2-Epinephrine
70.00Single8UNXEpinephrine8UNX-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
69.23Single3P0GBI1671073P0G-β2-BI167107
69.23Single3SN6BI1671073SN6-β2-BI167107-Gs/&β;1/&γ;2
69.23Single4LDLHydroxybenzylisoproterenol4LDL-β2-Hydroxybenzylisoproterenol
69.23Single6H7JIsoprenaline6H7J-β1-Isoprenaline
69.23Single6NI3BI1671076NI3-β2-BI167107-Gs/&β;1/&γ;2
69.23Single6WGTLSD6WGT-5-HT2A-LSD
69.23Single7JJOIsoprenaline7JJO-β1-Isoprenaline-Gs/&β;1/&γ;2
69.23Consensusdopamine_offOrthosteric Ligandd3_off d2_off d4_off
66.67Single2Y01Dobutamine2Y01-β1-Dobutamine
66.67Single2Y02Carmoterol2Y02-β1-Carmoterol
66.67Single2YCYCyanopindolol2YCY-β1-Cyanopindolol
66.67Single3NY8ICI 118-5513NY8-β2-ICI 118-551
66.67Single3ZPQ4-(piperazin-1- yl)-1H-indole3ZPQ-β1-4-(piperazin-1- yl)-1H-indole-Na
66.67Single4GBR(S)-Carazolol4GBR-β2-(S)-Carazolol
66.67Single4QKXPubChem 762106284QKX-β2-PubChem 76210628
66.67Single5JQH(S)-Carazolol5JQH-β2-(S)-Carazolol
66.67Single6PRZ(S)-Alprenolol6PRZ-β2-(S)-Alprenolol
66.67Single6PS0(S)-Carazolol6PS0-β2-(S)-Carazolol
66.67Single6PS2(S)-Alprenolol6PS2-β2-(S)-Alprenolol
66.67Single7BTSL-Epinephrine7BTS-β1-L-Epinephrine
66.67Single7BU6L-Norepinephrine7BU6-β1-L-Norepinephrine
66.67Single8GE3Epinephrine8GE3-β2-Epinephrine-Gs/&β;1/&γ;2
66.67Single8GEBEpinephrine8GEB-β2-Epinephrine-Gs/&β;1/&γ;2
66.67Single8GEEEpinephrine8GEE-β2-Epinephrine-Gs/&β;1/&γ;2
66.67Single8GEHEpinephrine8GEH-β2-Epinephrine-Gs/&β;1/&γ;2
66.67Single8GFWEpinephrine8GFW-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
66.67Single8GFXEpinephrine8GFX-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
66.67Single8GFYEpinephrine8GFY-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
66.67Single8GFZEpinephrine8GFZ-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
66.67Single8GG0Epinephrine8GG0-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
66.67Single8GG1Epinephrine8GG1-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
66.67Single8GG2Epinephrine8GG2-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
66.67Single8GG6Epinephrine8GG6-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
66.67Single8GGJEpinephrine8GGJ-β2-Epinephrine
66.67Single8GGNEpinephrine8GGN-β2-Epinephrine
66.67Single8GGOEpinephrine8GGO-β2-Epinephrine
66.67Single8GGUEpinephrine8GGU-β2-Epinephrine
66.67Single8UNNEpinephrine8UNN-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
66.67Single8UNPEpinephrine8UNP-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
66.67Single8UO4Epinephrine8UO4-β2-Epinephrine-GTP; Mg-Gs/&β;1/&γ;2
66.67Consensusadrenergic_onOrthosteric Ligandbeta_on alpha_on
66.67Consensusamine_onOrthosteric Ligandadrenergic_on histamine_on muscarinic_on tar_on 5ht_on dopamine_on
66.67Consensusd5_onOrthosteric Ligand8IRV-D5-Rotigotine-chim(NtGi1-Gs)/&β;1/&γ;2
66.67Consensusdopamine_onOrthosteric Ligandd3_on d2_on d5_on d1_on
64.29Single4AMIBucindolol4AMI-β1-Bucindolol
64.29Single4LDEBI1671074LDE-β2-BI167107
64.29Single5F8UCyanopindolol5F8U-β1-Cyanopindolol
64.29Single6H7N(S)-Xamoterol6H7N-β1-(S)-Xamoterol
64.29Single6H7OCyanopindolol6H7O-β1-Cyanopindolol
64.29Single6TKOArformoterol6TKO-β1-Arformoterol-Arrestin2
64.29Single7DH5Mirabegron7DH5-β3-Mirabegron-Gs/&β;1/&γ;2
64.29Single8JJ8Formoterol8JJ8-β2-Formoterol
64.29Single8JJLOlodaterol8JJL-β2-Olodaterol
64.29Consensusbeta1_onOrthosteric Ligand7JJO-β1-Isoprenaline-Gs/&β;1/&γ;2 8DCR-β1-Dobutamine-Gs/&β;1/&γ;2
64.29Consensusgo_5htOrthosteric Ligand6G79-5-HT1B-Donitriptan-Go/&β;1/&γ;2 7UM5-5-HT5A-5-CT-chim(NtGi1-Go)/&β;1/&γ;2 7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/&β;1/&γ;2 7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/&β;1/&γ;2
63.64Single7SRSLSD7SRS-5-HT2B-LSD-Arrestin2
63.64Single7X5H5-CT7X5H-5-HT5A-5-CT-Gi1/&β;1/&γ;2
63.64Single8GEAEpinephrine8GEA-β2-Epinephrine-Gs/&β;1/&γ;2
63.64Single8GEDEpinephrine8GED-β2-Epinephrine-Gs/&β;1/&γ;2
63.64Single8GG9Epinephrine8GG9-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
63.64Single8GGWEpinephrine8GGW-β2-Epinephrine
63.64Single8UNLEpinephrine8UNL-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
63.64Single8UNTEpinephrine8UNT-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
63.64Single8UNUEpinephrine8UNU-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
63.64Single8UNWEpinephrine8UNW-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
63.64Single8UO0Epinephrine8UO0-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
63.64Single8UO1Epinephrine8UO1-β2-Epinephrine-GTP; Mg-Gs/&β;1/&γ;2
63.64Single8UO3Epinephrine8UO3-β2-Epinephrine-GTP; Mg-Gs/&β;1/&γ;2
63.64Single8WC4ZH86518WC4-TA1-ZH8651-chim(NtGi1-Gs)/&β;1/&γ;2
63.64Single8WCA2-Phenylethylamine8WCA-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/&β;1/&γ;2
63.64Consensus5ht_onOrthosteric Ligand5ht1_on 5ht2_on 5ht4_on 5ht5_on 5ht6_on 5ht7_on
63.64Consensusalpha1_onOrthosteric Ligandalpha1a_on
63.64Consensusalpha1a_onOrthosteric Ligand7YMH-Alpha1A-Norepinephrine-chim(Gs-CtGq)/&β;1/&γ;2 7YM8-Alpha1A-Oxymetazoline-chim(Gs-CtGq)/&β;1/&γ;2 8THK-Alpha1A-A61603-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8THL-Alpha1A-Epinephrine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
63.64Consensusalpha2_offOrthosteric Ligandalpha2a_off alpha2c_off
61.54Single2RH1(S)-Carazolol2RH1-β2-(S)-Carazolol
61.54Single2Y00Dobutamine2Y00-β1-Dobutamine
61.54Single2YCW(S)-Carazolol2YCW-β1-(S)-Carazolol
61.54Single5D6L(S)-Carazolol5D6L-β2-(S)-Carazolol
61.54Single5WIUNemonapride5WIU-D4-Nemonapride
61.54Single5WIVNemonapride5WIV-D4-Nemonapride-Na
61.54Single5X7D(S)-Carazolol5X7D-β2-(S)-Carazolol-PubChem 129318963
61.54Single6ME82-Phenylmelatonin6ME8-MT2-2-Phenylmelatonin
61.54Single7BZ2Arformoterol7BZ2-β2-Arformoterol-Gs/&β;1/&γ;2
61.54Single7WC6LSD7WC6-5-HT2A-LSD
61.54Single7XKAEpinephrine7XKA-β2-Epinephrine
61.54Single8UNYEpinephrine8UNY-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
61.54Consensus5ht2b_offOrthosteric Ligand6DRZ-5-HT2B-Methysergide 6DRX-5-HT2B-Lisuride
61.54Consensusamine_offOrthosteric Ligandadrenergic_off histamine_off muscarinic_off 5ht_off dopamine_off
61.54Consensusbeta2_offOrthosteric Ligand6PS2-β2-(S)-Alprenolol 6PS3-β2-(S)-Carvedilol 6PS5-β2-(S)-Propranolol 6PS6-β2-Timolol 2RH1-β2-(S)-Carazolol 6PS4-β2-ICI 118-551 3NY9-β2-PubChem 913103
61.54Consensusbeta_offOrthosteric Ligandbeta1_off beta2_off
61.54Consensusd1_onOrthosteric Ligand7F0T-D1-Dopamine-Gs/&β;1/&γ;2 7CKY-D1-PW0464-Gs/&β;1/&γ;2 8IRR-D1-Rotigotine-Gs/&β;1/&γ;2 7JV5-D1-SKF81297-Gs/&β;1/&γ;2 7JVP-D1-SKF83959-Gs/&β;1/&γ;2 7X2D-D1-Tavapadon-Gs/&β;1/&γ;2 7JOZ-D1-VFP-Gs/&β;1/&γ;2 7CKX-D1-A77636-Gs/&β;1/&γ;2 7JVQ-D1-Apomorphine-Gs/&β;1/&γ;2
61.54Consensusd2_onOrthosteric Ligand7JVR-D2-Bromoergocryptine-Gi1/&β;1/&γ;2 8IRS-D2-Rotigotine-Gi1/&β;1/&γ;2
61.54Consensusd4_offOrthosteric Ligand5WIU-D4-Nemonapride
61.54Consensusd4_off_alloOrthosteric Ligand5WIV-D4-Nemonapride-Na
61.54Consensusta1_onOrthosteric Ligand8W87-TA1-METH-chim(NtGi1L-Gs)/&β;1/&γ;2 8W89-TA1-PEA-chim(NtGi1L-Gs)/&β;1/&γ;2 8JLP-TA1-Ralmitaront-Gs/&β;1/&γ;2 8W8A-TA1-RO5256390-chim(NtGi1L-Gs)/&β;1/&γ;2 8W88-TA1-SEP-363856-Gs/&β;1/&γ;2 8JLN-TA1-T1AM-Gs/&β;1/&γ;2 8JLO-TA1-Ulotaront-Gs/&β;1/&γ;2 8JLR-TA1-A77636-chim(NtGi1-Gs)/&β;1/&γ;2 8JSO-TA1-AMPH-chim(NtGi1-Gs)/&β;1/&γ;2 8JLQ-TA1-Fenoldopam-Gs/&β;1/&γ;2 8WCA-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/&β;1/&γ;2
60.00Single2YCZIodocyanopindolol2YCZ-β1-Iodocyanopindolol
60.00Single6H7LDobutamine6H7L-β1-Dobutamine
60.00Single6IBLArformoterol6IBL-β1-Arformoterol
60.00Single7JVRBromoergocryptine7JVR-D2-Bromoergocryptine-Gi1/&β;1/&γ;2
60.00Single7XJISolabegron7XJI-β3-Solabegron-Gs/&β;1/&γ;2
60.00Single8GGZEpinephrine8GGZ-β2-Epinephrine
60.00Single8POKHistamine8POK-H2-Histamine-Gs/&β;1/&γ;2
60.00Single8WC9ZH86518WC9-TA1-ZH8651-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
58.33Single6A94Zotepine6A94-5-HT2A-Zotepine
58.33Single7CMUPramipexole7CMU-D3-Pramipexole-Gi1/&β;1/&γ;2
58.33Single7RANPubChem 1645758477RAN-5-HT2A-PubChem 164575847-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
58.33Single8GG3Epinephrine8GG3-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
58.33Single8GG5Epinephrine8GG5-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
58.33Single8GG8Epinephrine8GG8-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
58.33Single8GGLEpinephrine8GGL-β2-Epinephrine
58.33Single8JLNT1AM8JLN-TA1-T1AM-Gs/&β;1/&γ;2
58.33Single8JLQFenoldopam8JLQ-TA1-Fenoldopam-Gs/&β;1/&γ;2
58.33Single8JSPUlotaront8JSP-5-HT1A-Ulotaront-Gi1/&β;1/&γ;2
58.33Single8THKA616038THK-Alpha1A-A61603-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
58.33Single8THLEpinephrine8THL-Alpha1A-Epinephrine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
58.33Single8UNREpinephrine8UNR-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
58.33Single8UNSEpinephrine8UNS-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
58.33Single8UO2Epinephrine8UO2-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
58.33Single8W88SEP-3638568W88-TA1-SEP-363856-Gs/&β;1/&γ;2
58.33Consensusd3_onOrthosteric Ligand8IRT-D3-Rotigotine-Gi1/&β;1/&γ;2 7CMV-D3-PD128907-Gi1/&β;1/&γ;2 7CMU-D3-Pramipexole-Gi1/&β;1/&γ;2
58.33Consensusgs_tarOrthosteric Ligand8W88-TA1-SEP-363856-Gs/&β;1/&γ;2 8JLN-TA1-T1AM-Gs/&β;1/&γ;2 8JLO-TA1-Ulotaront-Gs/&β;1/&γ;2 8JLQ-TA1-Fenoldopam-Gs/&β;1/&γ;2 8JLP-TA1-Ralmitaront-Gs/&β;1/&γ;2 8WCA-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/&β;1/&γ;2 8WCB-TA1-Cyclohexylammonium ion-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8WC8-TA1-ZH8651-chim(NtGi1-Gs)/&β;1/&γ;2
57.14Single2YDVNECA2YDV-A2A-NECA
57.14Single3PDSHydroxybenzylisoproterenol3PDS-β2-Hydroxybenzylisoproterenol
57.14Single4UHRCGS216804UHR-A2A-CGS21680
57.14Single5A8E7-Methylcyanopindolol5A8E-β1-7-Methylcyanopindolol-Na
57.14Single5D5A(S)-Carazolol5D5A-β2-(S)-Carazolol
57.14Single5D5B(S)-Carazolol5D5B-β2-(S)-Carazolol
57.14Single5G53NECA5G53-A2A-NECA-Gs
57.14Single5ZKBAF-DX 3845ZKB-M2-AF-DX 384
57.14Single6N48BI1671076N48-β2-BI167107-PubChem 138454256
57.14Single7B6WCyclazosin7B6W-α1b-Cyclazosin
57.14Single7CKYPW04647CKY-D1-PW0464-Gs/&β;1/&γ;2
57.14Single7E2ZAripiprazole7E2Z-5-HT1A-Aripiprazole-Gi1/&β;1/&γ;2
57.14Single7JVPSKF839597JVP-D1-SKF83959-Gs/&β;1/&γ;2
57.14Single7W6PW967W6P-α2a-W96-Go/&β;1/&γ;2
57.14Single7W7EW587W7E-α2a-W58-Go/&β;1/&γ;2
57.14Single8DCSCyanopindolol8DCS-β1-Cyanopindolol-Gs/&β;1/&γ;2
57.14Single8IRRRotigotine8IRR-D1-Rotigotine-Gs/&β;1/&γ;2
57.14Single8JT6(R)-IHCH-71798JT6-5-HT1A-(R)-IHCH-7179-Gi1/&β;1/&γ;2
57.14Consensus5ht5_offOrthosteric Ligand5ht5a_off
57.14Consensus5ht_offOrthosteric Ligand5ht2_off 5ht5_off 5ht1_off
57.14Consensusalpha1b_offOrthosteric Ligand7B6W-α1b-Cyclazosin
57.14Consensusbeta1_offOrthosteric Ligand2VT4-β1-Cyanopindolol 2YCZ-β1-Iodocyanopindolol
57.14Consensusgi_amineOrthosteric Ligandgi_5ht gi_adrenergic gi_dopamine gi_muscarinic gi_histamine
57.14Consensusgi_dopamineOrthosteric Ligand8IRT-D3-Rotigotine-Gi1/&β;1/&γ;2 7JVR-D2-Bromoergocryptine-Gi1/&β;1/&γ;2 8IRS-D2-Rotigotine-Gi1/&β;1/&γ;2 7CMV-D3-PD128907-Gi1/&β;1/&γ;2 7CMU-D3-Pramipexole-Gi1/&β;1/&γ;2
57.14Consensusgs_dopamineOrthosteric Ligand7F0T-D1-Dopamine-Gs/&β;1/&γ;2 7CKX-D1-A77636-Gs/&β;1/&γ;2 7JVQ-D1-Apomorphine-Gs/&β;1/&γ;2 7CKY-D1-PW0464-Gs/&β;1/&γ;2 8IRV-D5-Rotigotine-chim(NtGi1-Gs)/&β;1/&γ;2 7JV5-D1-SKF81297-Gs/&β;1/&γ;2 7JVP-D1-SKF83959-Gs/&β;1/&γ;2 7X2D-D1-Tavapadon-Gs/&β;1/&γ;2 7JOZ-D1-VFP-Gs/&β;1/&γ;2
55.56Single8GEJEpinephrine8GEJ-β2-Epinephrine-Gs/&β;1/&γ;2
55.56Consensusgabab_offOther Ligand7C7S-GABAB1, GABAB2-CGP54626 7CUM-GABAB1, GABAB2-CGP54626-Phospholipid 6W2X-GABAB1, GABAB2-PubChem 5311042-PubChem 23727970
54.55Single3PBLEticlopride3PBL-D3-Eticlopride
54.55Single7EJKOxymetazoline7EJK-α2a-Oxymetazoline-Go/&β;1/&γ;2
54.55Single7XT9Serotonin7XT9-5-HT4-Serotonin-Gs/&β;1/&γ;2
54.55Single7XTASerotonin7XTA-5-HT4-Serotonin-Gi1/&β;1/&γ;2
54.55Single7XTBSerotonin7XTB-5-HT6-Serotonin-Gs/&β;1/&γ;2
54.55Single7YS6Serotonin7YS6-5-HT6-Serotonin-chim(NtGi1-Gs)/&β;1/&γ;2
54.55Single8DPFLorcaserin8DPF-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
54.55Single8EF6Morphine8EF6-μ-Morphine-Gi1/&β;1/&γ;2
54.55Single8GGCEpinephrine8GGC-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
54.55Single8GGEEpinephrine8GGE-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
54.55Single8GH1Epinephrine8GH1-β2-Epinephrine
54.55Single8JLOUlotaront8JLO-TA1-Ulotaront-Gs/&β;1/&γ;2
54.55Single8JSOAMPH8JSO-TA1-AMPH-chim(NtGi1-Gs)/&β;1/&γ;2
54.55Single8WC3SEP-3638568WC3-TA1-SEP-363856-chim(NtGi1-Gs)/&β;1/&γ;2
54.55Consensus5ht4_onOrthosteric Ligand7XT8-5-HT4-Serotonin-Gs/&β;1/&γ;2
54.55Consensusd3_offOrthosteric Ligand3PBL-D3-Eticlopride
53.85Single2VT4Cyanopindolol2VT4-β1-Cyanopindolol
53.85Single3NYA(S)-Alprenolol3NYA-β2-(S)-Alprenolol
53.85Single3ZPR4-methyl-2-(piperazin-1-yl)3ZPR-β1-4-methyl-2-(piperazin-1-yl)-Na
53.85Single6DRXLisuride6DRX-5-HT2B-Lisuride
53.85Single6DRZMethysergide6DRZ-5-HT2B-Methysergide
53.85Single6PS1Timolol6PS1-β2-Timolol
53.85Single7BU7BI1671077BU7-β1-BI167107
53.85Single7CRHSKF839597CRH-D1-SKF83959-Gs/&β;1/&γ;2
53.85Single7E32Serotonin7E32-5-HT1D-Serotonin-Gi1/&β;1/&γ;2
53.85Single7JVQApomorphine7JVQ-D1-Apomorphine-Gs/&β;1/&γ;2
53.85Single7UM55-CT7UM5-5-HT5A-5-CT-chim(NtGi1-Go)/&β;1/&γ;2
53.85Single7VGZRemalteon7VGZ-MT1-Remalteon-Gi1/&β;1/&γ;2
53.85Single7XTC5-CT7XTC-5-HT7-5-CT-Gs/&β;1/&γ;2
53.85Single8GGBEpinephrine8GGB-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
53.85Single8IRTRotigotine8IRT-D3-Rotigotine-Gi1/&β;1/&γ;2
53.85Single8JJOAlprenolol8JJO-β2-Alprenolol
53.85Single8JLJT1AM8JLJ-TA1-T1AM-chim(NtGi1-Gs)/&β;1/&γ;2
53.85Single8UNMEpinephrine8UNM-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
53.85Single8W87METH8W87-TA1-METH-chim(NtGi1L-Gs)/&β;1/&γ;2
53.85Single8W8ARO52563908W8A-TA1-RO5256390-chim(NtGi1L-Gs)/&β;1/&γ;2
53.85Single8WC7ZH86678WC7-TA1-ZH8667-chim(NtGi1-Gs)/&β;1/&γ;2
53.85Consensus5ht1a_onOrthosteric Ligand8JSP-5-HT1A-Ulotaront-Gi1/&β;1/&γ;2 7E2Z-5-HT1A-Aripiprazole-Gi1/&β;1/&γ;2 8W8B-5-HT1A-SEP-363856-Gi1/&β;1/&γ;2 7E2Y-5-HT1A-Serotonin-Gi1/&β;1/&γ;2
53.85Consensus5ht1d_onOrthosteric Ligand7E32-5-HT1D-Serotonin-Gi1/&β;1/&γ;2
53.85Consensus5ht2_offOrthosteric Ligand5ht2a_off 5ht2b_off 5ht2c_off
53.85Consensus5ht7_onOrthosteric Ligand7XTC-5-HT7-5-CT-Gs/&β;1/&γ;2
53.85Consensusalpha2_onOrthosteric Ligandalpha2a_on alpha2b_on
53.85Consensusalpha_offOrthosteric Ligandalpha1_off alpha2_off
53.85Consensusalpha_onOrthosteric Ligandalpha1_on alpha2_on
53.85Consensusgi_5htOrthosteric Ligand7E2Y-5-HT1A-Serotonin-Gi1/&β;1/&γ;2 8JSP-5-HT1A-Ulotaront-Gi1/&β;1/&γ;2 7E32-5-HT1D-Serotonin-Gi1/&β;1/&γ;2 7E33-5-HT1E-BRL-54443-Gi1/&β;1/&γ;2 7EXD-5-HT1F-Lasmiditan-Gi1/&β;1/&γ;2 7XTA-5-HT4-Serotonin-Gi1/&β;1/&γ;2 7X5H-5-HT5A-5-CT-Gi1/&β;1/&γ;2 7E2Z-5-HT1A-Aripiprazole-Gi1/&β;1/&γ;2 8W8B-5-HT1A-SEP-363856-Gi1/&β;1/&γ;2
53.85Consensustar_onOrthosteric Ligandta1_on
53.33Single2YCXCyanopindolol2YCX-β1-Cyanopindolol
53.33Single3D4STimolol Maleate3D4S-β2-Timolol Maleate
53.33Single6DRYMethylergonovine6DRY-5-HT2B-Methylergonovine
53.33Single6MXTSalmeterol6MXT-β2-Salmeterol
53.33Single6VMSBromoergocryptine6VMS-D2-Bromoergocryptine-Gi1/&β;1/&γ;2
53.33Single7YMJTamsulosin7YMJ-Alpha1A-Tamsulosin
53.33Single8IRVRotigotine8IRV-D5-Rotigotine-chim(NtGi1-Gs)/&β;1/&γ;2
53.33Consensusgs_amineOrthosteric Ligandgs_5ht gs_adrenergic gs_dopamine gs_histamine gs_muscarinic gs_tar
52.94Single4AMJ(S)-Carvedilol4AMJ-β1-(S)-Carvedilol
52.94Single8DCRDobutamine8DCR-β1-Dobutamine-Gs/&β;1/&γ;2
50.00Single4BVNCyanopindolol4BVN-β1-Cyanopindolol-Na
50.00Single5C1MBU725C1M-μ-BU72
50.00Single6AKXA4R6AKX-CCR5-A4R
50.00Single6AKYMaraviroc6AKY-CCR5-Maraviroc
50.00Single6BQGErgotamine6BQG-5-HT2C-Ergotamine
50.00Single6DDFDamgo6DDF-μ-Damgo-Gi1/&β;1/&γ;2
50.00Single6KUYPubChem 1457046436KUY-α2a-PubChem 145704643
50.00Single6ME2Ramelteon6ME2-MT1-Ramelteon
50.00Single6ME72-Phenylmelatonin6ME7-MT2-2-Phenylmelatonin
50.00Single6PS6Timolol6PS6-β2-Timolol
50.00Single7CKXA776367CKX-D1-A77636-Gs/&β;1/&γ;2
50.00Single7DHRIsoprenaline7DHR-β2-Isoprenaline-Gs/&β;1/&γ;2
50.00Single7F1ODopamine7F1O-D1-Dopamine-GDP; Mg-Gs/&β;1/&γ;2
50.00Single7F24Dopamine7F24-D1-Dopamine-GDP-Gs/&β;1/&γ;2
50.00Single7LD4Adenosine7LD4-A1-Adenosine-Gi2/&β;1/&γ;2
50.00Single7SBFPZM217SBF-μ-PZM21-Gi1/&β;1/&γ;2
50.00Single7SRRLSD7SRR-5-HT2B-LSD-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
50.00Single7UM4AS26747237UM4-5-HT5A-AS2674723
50.00Single7X2DTavapadon7X2D-D1-Tavapadon-Gs/&β;1/&γ;2
50.00Single7X2FDopamine7X2F-D1-Dopamine-Mevidalen-Gs/&β;1/&γ;2
50.00Single7XT8Serotonin7XT8-5-HT4-Serotonin-Gs/&β;1/&γ;2
50.00Single7YM8Oxymetazoline7YM8-Alpha1A-Oxymetazoline-chim(Gs-CtGq)/&β;1/&γ;2
50.00Single8C9WEtrumadenant8C9W-A2A-Etrumadenant
50.00Single8DPHLorcaserin8DPH-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
50.00Single8DZQmomSalB8DZQ-κ-momSalB-Go/&β;1/&γ;2
50.00Single8DZRGR89,6968DZR-κ-GR89,696-chim(NtGi2-Gt3)/&β;1/&γ;2
50.00Single8GGFEpinephrine8GGF-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
50.00Single8IW4Spermidine8IW4-TAAR9-Spermidine-chim(NtGi1-Gs)/&β;1/&γ;2
50.00Single8IWESpermidine8IWE-TAAR9-Spermidine
50.00Consensus5ht1_onOrthosteric Ligand5ht1a_on 5ht1d_on 5ht1e_on 5ht1f_on 5ht1b_on
50.00Consensus5ht2_onOrthosteric Ligand5ht2a_on 5ht2c_on
50.00Consensus5ht2c_onOrthosteric Ligand8DPF-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8DPG-5-HT2C-Psilocin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
50.00Consensus5ht5a_offOrthosteric Ligand7UM4-5-HT5A-AS2674723
50.00Consensusa1_onOrthosteric Ligand7LD4-A1-Adenosine-Gi2/&β;1/&γ;2
50.00Consensusalpha2a_onOrthosteric Ligand7EJ0-α2a-L-Norepinephrine-Go/&β;1/&γ;2 7EJK-α2a-Oxymetazoline-Go/&β;1/&γ;2 7W7E-α2a-W58-Go/&β;1/&γ;2 7W6P-α2a-W96-Go/&β;1/&γ;2 7EJ8-α2a-Brimonidine-Go/&β;1/&γ;2 7EJA-α2a-Dexmedetomidine-Go/&β;1/&γ;2
50.00Consensusbeta1_off_alloOrthosteric Ligand4BVN-β1-Cyanopindolol-Na
50.00Consensusgi_nucleotideOrthosteric Ligand7LD4-A1-Adenosine-Gi2/&β;1/&γ;2
50.00Consensusgo_amineOrthosteric Ligandgo_adrenergic go_muscarinic go_5ht
50.00Consensusgo_opioidOrthosteric Ligand8DZQ-κ-momSalB-Go/&β;1/&γ;2
50.00Consensusgs_5htOrthosteric Ligand7XT8-5-HT4-Serotonin-Gs/&β;1/&γ;2 7XTB-5-HT6-Serotonin-Gs/&β;1/&γ;2 8JLZ-5-HT6-ST1936-Gs/&β;1/&γ;2 7XTC-5-HT7-5-CT-Gs/&β;1/&γ;2 6WHA-5-HT2A-DB13948-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 7RAN-5-HT2A-PubChem 164575847-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8DPF-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8DPG-5-HT2C-Psilocin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
47.06Single3NY9PubChem 9131033NY9-β2-PubChem 913103
47.06Single4UG2CGS216804UG2-A2A-CGS21680
47.06Single8JLRA776368JLR-TA1-A77636-chim(NtGi1-Gs)/&β;1/&γ;2
47.06Single8X5YAstemizole8X5Y-H1-Astemizole
46.67Single4IAQDihydroergotamine4IAQ-5-HT1B-Dihydroergotamine
46.67Single4RWADIPP-NH24RWA-δ-DIPP-NH2
46.67Single4RWDDIPP-NH24RWD-δ-DIPP-NH2-Na
46.67Single4U15Tiotropium4U15-M3-Tiotropium
46.67Single5V54Methiothepin5V54-5-HT1B-Methiothepin
46.67Single6J21Aprepitant6J21-NK1-Aprepitant
46.67Single6OL9Tiotropium6OL9-M5-Tiotropium
46.67Single7JV5SKF812977JV5-D1-SKF81297-Gs/&β;1/&γ;2
46.67Single7VGY2-Iodomelatonin7VGY-MT1-2-Iodomelatonin-Gi1/&β;1/&γ;2
46.67Single8DZPmomSalB8DZP-κ-momSalB-Gi1/&β;1/&γ;2
46.67Single8E0GBU728E0G-μ-BU72
46.67Single8IRURotigotine8IRU-D4-Rotigotine-chim(NtGi1-Gs-CtGi1)/&β;1/&γ;2
46.67Single8JLPRalmitaront8JLP-TA1-Ralmitaront-Gs/&β;1/&γ;2
46.67Consensus5ht1_offOrthosteric Ligand5ht1b_off
46.67Consensus5ht1b_offOrthosteric Ligand5V54-5-HT1B-Methiothepin
46.67Consensusa2_onOrthosteric Liganda2a_on a2b_on
46.67Consensusgo_adrenergicOrthosteric Ligand7EJ0-α2a-L-Norepinephrine-Go/&β;1/&γ;2 7EJK-α2a-Oxymetazoline-Go/&β;1/&γ;2 7W7E-α2a-W58-Go/&β;1/&γ;2 7W6P-α2a-W96-Go/&β;1/&γ;2 6K41-α2b-Dexmedetomidine-Go/&β;1/&γ;2 7EJ8-α2a-Brimonidine-Go/&β;1/&γ;2 7EJA-α2a-Dexmedetomidine-Go/&β;1/&γ;2
46.67Consensush1_offOrthosteric Ligand3RZE-H1-Cidoxepin 8X5Y-H1-Astemizole 8X63-H1-Mepyramine 8X64-H1-Desloratadine
46.67Consensushistamine_offOrthosteric Ligandh1_off
46.67Consensusm3_offOrthosteric Ligand4U15-M3-Tiotropium 4U16-M3-N-Methyl Scopolamine 5ZHP-M3-PubChem 134828589
46.67Consensusm5_offOrthosteric Ligand6OL9-M5-Tiotropium
46.67Consensusmuscarinic_offOrthosteric Ligandm2_off m3_off m4_off m5_off m1_off
46.67Consensusnk1_offOrthosteric Ligand6J20-NK1-Aprepitant 6HLL-NK1-CP99994 6E59-NK1-L-760735
46.15Single4MBSMaraviroc4MBS-CCR5-Maraviroc
46.15Single4MQTIperoxo4MQT-M2-Iperoxo-LY2119620
46.15Single6K41Dexmedetomidine6K41-α2b-Dexmedetomidine-Go/&β;1/&γ;2
46.15Single6ME32-Phenylmelatonin6ME3-MT1-2-Phenylmelatonin
46.15Single6ME42-Iodomelatonin6ME4-MT1-2-Iodomelatonin
46.15Single6TPGEMPA6TPG-OX2-EMPA
46.15Single6TPNHTL66416TPN-OX2-HTL6641
46.15Single6WH4Methiothepin6WH4-5-HT2A-Methiothepin
46.15Single6WJCAtropine6WJC-M1-Atropine-Muscarinic toxin 7
46.15Single7CKWFenoldopam7CKW-D1-Fenoldopam-Gs/&β;1/&γ;2
46.15Single7CKZDopamine7CKZ-D1-Dopamine-Mevidalen-Gs/&β;1/&γ;2
46.15Single7E33BRL-544437E33-5-HT1E-BRL-54443-Gi1/&β;1/&γ;2
46.15Single7F0TDopamine7F0T-D1-Dopamine-Gs/&β;1/&γ;2
46.15Single7JOZVFP7JOZ-D1-VFP-Gs/&β;1/&γ;2
46.15Single7SR8TAK-9257SR8-OX2-TAK-925-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
46.15Single8FCZ11-cis-Retinal8FCZ-Rhodopsin-11-cis-Retinal
46.15Single8JLKUlotaront8JLK-TA1-Ulotaront-chim(NtGi1-Gs)/&β;1/&γ;2
46.15Single8UHBRO52563908UHB-TA1-RO5256390-Gs/&β;1/&γ;2
46.15Consensus5ht1e_onOrthosteric Ligand7E33-5-HT1E-BRL-54443-Gi1/&β;1/&γ;2
46.15Consensus5ht2a_offOrthosteric Ligand6A94-5-HT2A-Zotepine 6WH4-5-HT2A-Methiothepin 7VOE-5-HT2A-Aripiprazole 7VOD-5-HT2A-Cariprazine 7WC8-5-HT2A-Lumateperone 6A93-5-HT2A-Risperidone
46.15Consensus5ht2a_onOrthosteric Ligand7RAN-5-HT2A-PubChem 164575847-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 6WHA-5-HT2A-DB13948-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
46.15Consensusalpha2b_onOrthosteric Ligand6K41-α2b-Dexmedetomidine-Go/&β;1/&γ;2
46.15Consensusd1_on_alloOrthosteric Ligand7LJC-D1-PubChem 86764103-Mevidalen-Gs/&β;1/&γ;2 7CKZ-D1-Dopamine-Mevidalen-Gs/&β;1/&γ;2
46.15Consensusm1_off_alloOrthosteric Ligand6WJC-M1-Atropine-Muscarinic toxin 7
46.15Consensusox2_offOrthosteric Ligand6TPN-OX2-HTL6641 7XRR-OX2-Lemborexant
45.45Single6FUFAll-trans-retinal6FUF-Rhodopsin-All-trans-retinal-Go/&β;1/&γ;2
45.45Single8DPILorcaserin8DPI-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
45.45Single8WC62-Phenylethylamine8WC6-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/&β;1/&γ;2
45.00Single7C61Ergotamine7C61-5-HT1B-Ergotamine
44.44Single4IARErgotamine4IAR-5-HT1B-Ergotamine
44.44Consensusmop_offOrthosteric Ligand7UL4-μ-Alvimopan 4DKL-μ-Beta-funaltrexamine 8QOT-μ-Nanobody E
43.75Single5CXVTiotropium5CXV-M1-Tiotropium
43.75Single6ME62-Phenylmelatonin6ME6-MT2-2-Phenylmelatonin
43.75Single7EXDLasmiditan7EXD-5-HT1F-Lasmiditan-Gi1/&β;1/&γ;2
43.75Single7YITNalfurafine7YIT-κ-Nalfurafine
43.75Single8IRSRotigotine8IRS-D2-Rotigotine-Gi1/&β;1/&γ;2
43.75Consensus5ht1f_onOrthosteric Ligand7EXD-5-HT1F-Lasmiditan-Gi1/&β;1/&γ;2
43.75Consensusd2_offOrthosteric Ligand6CM4-D2-Risperidone 6LUQ-D2-Haloperidol 7DFP-D2-Spiperone
43.75Consensusm1_offOrthosteric Ligand5CXV-M1-Tiotropium
43.75Consensusmop_onOrthosteric Ligand8F7Q-μ-Beta-endorphin-Gi1/&β;1/&γ;2 8EFQ-μ-Damgo-Gi1/&β;1/&γ;2 8F7R-μ-Endomorphin-Gi1/&β;1/&γ;2 8EF5-μ-Fentanyl-Gi1/&β;1/&γ;2 8EF6-μ-Morphine-Gi1/&β;1/&γ;2 8EFB-μ-Oliceridine-Gi1/&β;1/&γ;2 8EFO-μ-PZM21-Gi1/&β;1/&γ;2 8EFL-μ-SR17018-Gi1/&β;1/&γ;2
43.75Consensusopioid_offOrthosteric Ligandkop_off mop_off nop_off dop_off
42.86Single1HZX11-cis-Retinal1HZX-Rhodopsin-11-cis-Retinal
42.86Single4DAJTiotropium4DAJ-M3-Tiotropium
42.86Single4EJ4Naltrindole4EJ4-δ-Naltrindole
42.86Single4MQSIperoxo4MQS-M2-Iperoxo
42.86Single4U14Tiotropium4U14-M3-Tiotropium
42.86Single4U16N-Methyl Scopolamine4U16-M3-N-Methyl Scopolamine
42.86Single5YC8N-Methyl Scopolamine5YC8-M2-N-Methyl Scopolamine
42.86Single5ZK8N-Methyl Scopolamine5ZK8-M2-N-Methyl Scopolamine
42.86Single5ZKCN-Methyl Scopolamine5ZKC-M2-N-Methyl Scopolamine
42.86Single6K42Dexmedetomidine6K42-α2b-Dexmedetomidine-Gi1/&β;1/&γ;2
42.86Single6PS82-Phenylmelatonin6PS8-MT1-2-Phenylmelatonin
42.86Single7LJCPubChem 867641037LJC-D1-PubChem 86764103-Mevidalen-Gs/&β;1/&γ;2
42.86Single7SCGFH2107SCG-μ-FH210-Gi1/&β;1/&γ;2
42.86Single7SQOTAK-9257SQO-OX2-TAK-925-Gi1/&β;1/&γ;2
42.86Single7T2GMitragynine pseudoindoxyl7T2G-μ-Mitragynine pseudoindoxyl-Gi1/&β;1/&γ;2
42.86Single7T6VfMLFII7T6V-FPR2-ALX-fMLFII-Gi1/&β;1/&γ;2
42.86Single7TRPIperoxo7TRP-M4-Iperoxo-LY2033298-Gi1/&β;1/&γ;2
42.86Single7UL4Alvimopan7UL4-μ-Alvimopan
42.86Single7VH0Ramelteon7VH0-MT2-Ramelteon-Gi1/&β;1/&γ;1
42.86Single7X2CFenoldopam7X2C-D1-Fenoldopam-Fenoldopam-Gs/&β;1/&γ;2
42.86Single7YACPaltusotine7YAC-SST2-Paltusotine-Gi1/&β;1/&γ;2
42.86Single8CICEtrumadenant8CIC-A2A-Etrumadenant-Na
42.86Single8DZSGR89,6968DZS-κ-GR89,696-chim(NtGi2-Gz)/&β;1/&γ;2
42.86Single8EFQDamgo8EFQ-μ-Damgo-Gi1/&β;1/&γ;2
42.86Single8J18(3R)-3-hydroxydodecanoic acid8J18-GPR84-(3R)-3-hydroxydodecanoic acid-Gi1/&β;1/&γ;2
42.86Single8JLZST19368JLZ-5-HT6-ST1936-Gs/&β;1/&γ;2
42.86Single8X63Mepyramine8X63-H1-Mepyramine
42.86Single8X64Desloratadine8X64-H1-Desloratadine
42.86Consensus5ht6_onOrthosteric Ligand7XTB-5-HT6-Serotonin-Gs/&β;1/&γ;2 8JLZ-5-HT6-ST1936-Gs/&β;1/&γ;2
42.86Consensusdop_offOrthosteric Ligand4EJ4-δ-Naltrindole
42.86Consensusgo_muscarinicOrthosteric Ligand8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/&β;1/&γ;2 7T8X-M2-Acetylcholine-chim(NtGi1-Go)/&β;1/&γ;2
42.86Consensusgq_amineOrthosteric Ligandgq_muscarinic gq_histamine
42.86Consensushistamine_onOrthosteric Ligandh1_on h4_on
42.86Consensusm4_on_alloOrthosteric Ligand7TRP-M4-Iperoxo-LY2033298-Gi1/&β;1/&γ;2 7TRQ-M4-Iperoxo-VU0467154-Gi1/&β;1/&γ;2 7V68-M4-Iperoxo-PubChem 57664406-Gi1/&β;1/&γ;2
42.11Single4IB4Ergotamine4IB4-5-HT2B-Ergotamine
42.11Single7CUMPhospholipid7CUM-GABAB1, GABAB2-CGP54626-Phospholipid
42.11Consensusalpha1_offOrthosteric Ligandalpha1a_off alpha1b_off
41.67Single6HLLCP999946HLL-NK1-CP99994
41.67Single6TP4ACT-4622066TP4-OX1-ACT-462206
41.67Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
41.67Single7DFLHistamine7DFL-H1-Histamine-chim(NtGi1L-Gq)/&β;1/&γ;2
41.67Single7E2YSerotonin7E2Y-5-HT1A-Serotonin-Gi1/&β;1/&γ;2
41.67Single7SRQLSD7SRQ-5-HT2B-LSD
41.67Single7YFCHistamine7YFC-H4-Histamine-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
41.67Single8W89PEA8W89-TA1-PEA-chim(NtGi1L-Gs)/&β;1/&γ;2
41.67Single8W8BSEP-3638568W8B-5-HT1A-SEP-363856-Gi1/&β;1/&γ;2
41.67Consensusgq_histamineOrthosteric Ligand7DFL-H1-Histamine-chim(NtGi1L-Gq)/&β;1/&γ;2
41.67Consensush1_onOrthosteric Ligand7DFL-H1-Histamine-chim(NtGi1L-Gq)/&β;1/&γ;2
41.67Consensusmt2_onOrthosteric Ligand7VH0-MT2-Ramelteon-Gi1/&β;1/&γ;1
41.18Single4NC3Ergotamine4NC3-5-HT2B-Ergotamine
41.18Single5TUDErgotamine5TUD-5-HT2B-Ergotamine
41.18Single5UNGPubChem 157800525UNG-AT2-PubChem 15780052
41.18Single5UNHPubChem 1264564065UNH-AT2-PubChem 126456406
41.18Single6BQHRitanserin6BQH-5-HT2C-Ritanserin
41.18Single6G79Donitriptan6G79-5-HT1B-Donitriptan-Go/&β;1/&γ;2
41.18Single7SK8CCX6627SK8-ACKR3-CXCL12-CCX662
41.18Single7U2KC6-guano7U2K-μ-C6-guano-Gi1/&β;1/&γ;2
41.18Single8E9X2-Deoxycytidine8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/&β;1/&γ;2
41.18Single8E9YPubChem 4466038E9Y-M3-PubChem 446603-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
41.18Single8FX5Xanomeline8FX5-M4-Xanomeline-Xanomeline-Gi1/&β;1/&γ;2
41.18Consensus5ht2c_offOrthosteric Ligand6BQH-5-HT2C-Ritanserin
41.18Consensusclass-a_onOrthosteric Ligandsensory_on amine_on lipid_on nucleotide_on peptide_on protein_on hcar_on steroid_on melatonin_on
41.18Consensusendothelin_offOrthosteric Ligandetb_off
41.18Consensusetb_offOrthosteric Ligand5XPR-ETB-Bosentan 6K1Q-ETB-IRL2500 5X93-ETB-K-8794
41.18Consensusgi_class-aOrthosteric Ligandgi_amine gi_lipid gi_melatonin gi_peptide gi_protein gi_nucleotide gi_hcar
40.00Single5WQCEMPA5WQC-OX2-EMPA
40.00Single5XPRBosentan5XPR-ETB-Bosentan
40.00Single5ZK3Quinuclidinyl benzilate hydrobromide5ZK3-M2-Quinuclidinyl benzilate hydrobromide
40.00Single6DDEDamgo6DDE-μ-Damgo-Gi1/&β;1/&γ;2
40.00Single6LUQHaloperidol6LUQ-D2-Haloperidol
40.00Single6TP6Filorexant6TP6-OX1-Filorexant
40.00Single6W2XPubChem 237279706W2X-GABAB1, GABAB2-PubChem 5311042-PubChem 23727970
40.00Single7CFNINT-7777CFN-GPBA-INT-777-Gs/&β;1/&γ;2
40.00Single7EW3S1P7EW3-S1P3-S1P-Gi1/&β;1/&γ;2
40.00Single7LD3Adenosine7LD3-A1-Adenosine-PubChem 25263603-Gi2/&β;1/&γ;2
40.00Single7TRKIperoxo7TRK-M4-Iperoxo-Gi1/&β;1/&γ;2
40.00Single7VOEAripiprazole7VOE-5-HT2A-Aripiprazole
40.00Single7WC4Serotonin7WC4-5-HT2A-Serotonin
40.00Single8E9ZIperoxo8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
40.00Single8EA0Iperoxo8EA0-M3-Iperoxo
40.00Single8EFBOliceridine8EFB-μ-Oliceridine-Gi1/&β;1/&γ;2
40.00Single8HNLPS3724248HNL-CXCR3-PS372424-Gi1/&β;1/&γ;2
40.00Single8J19PubChem 1270454228J19-GPR84-PubChem 127045422-Gi1/&β;1/&γ;2
40.00Consensusa1_on_alloOrthosteric Ligand7LD3-A1-Adenosine-PubChem 25263603-Gi2/&β;1/&γ;2
40.00Consensusgs_muscarinicOrthosteric Ligand8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
40.00Consensusm2_offOrthosteric Ligand5ZKB-M2-AF-DX 384 5ZKC-M2-N-Methyl Scopolamine 5ZK3-M2-Quinuclidinyl benzilate hydrobromide
40.00Consensusm3_onOrthosteric Ligand8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
38.89Single6PT3DPI-2876PT3-δ-DPI-287
38.89Single7SK9CCX6627SK9-ACKR3-CCX662
38.89Single7XY6PubChem 117178317XY6-A2B-PubChem 11717831-chim(NtGi1-Gs)/&β;1/&γ;2
38.89Consensuslipid_onOrthosteric Ligandcannabinoid_on ffa_on gpr119_on leuko_on lpl_on prostanoid_on
38.46Single1GZM11-cis-Retinal1GZM-Rhodopsin-11-cis-Retinal
38.46Single2PED9-cis-Retinal2PED-Rhodopsin-9-cis-Retinal
38.46Single2X72All-trans-retinal2X72-Rhodopsin-All-trans-retinal-Gt(CT)
38.46Single3C9L11-cis-Retinal3C9L-Rhodopsin-11-cis-Retinal
38.46Single3VGAZM2413853VGA-A2A-ZM241385-Antibody
38.46Single6NWEOctyl Beta-D-Glucopyranoside6NWE-Rhodopsin-Octyl Beta-D-Glucopyranoside-Gt(CT)
38.46Single6TODEMPA6TOD-OX1-EMPA-Na
38.46Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
38.46Single7EJ0L-Norepinephrine7EJ0-α2a-L-Norepinephrine-Go/&β;1/&γ;2
38.46Single7LJDDopamine7LJD-D1-Dopamine-Mevidalen-Gs/&β;1/&γ;1
38.46Single7T6SPubChem 247763417T6S-FPR2-ALX-PubChem 24776341-Gi1/&β;1/&γ;2
38.46Single7T8XAcetylcholine7T8X-M2-Acetylcholine-chim(NtGi1-Go)/&β;1/&γ;2
38.46Single7T90Acetylcholine7T90-M2-Acetylcholine-chim(NtGi1-Go)/&β;1/&γ;2
38.46Single8EFOPZM218EFO-μ-PZM21-Gi1/&β;1/&γ;2
38.46Single8HDPAdenosine8HDP-A2B-Adenosine-Gs/&β;1/&γ;2
38.46Single8HOCImetit8HOC-H4-Imetit-Gi1/&β;1/&γ;2
38.46Consensusgi_histamineOrthosteric Ligand8HN8-H4-Histamine-Gi1/&β;1/&γ;2 8HOC-H4-Imetit-Gi1/&β;1/&γ;2
38.46Consensusgs_histamineOrthosteric Ligand7YFC-H4-Histamine-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7YFD-H4-Imetit-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
38.46Consensush4_onOrthosteric Ligand7YFC-H4-Histamine-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7YFD-H4-Imetit-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
38.46Consensusm2_onOrthosteric Ligand7T8X-M2-Acetylcholine-chim(NtGi1-Go)/&β;1/&γ;2
38.46Consensusmelatonin_onOrthosteric Ligandmt1_on mt2_on
38.46Consensusopsin_offOrthosteric Ligand1U19-Rhodopsin-11-cis-Retinal 2PED-Rhodopsin-9-cis-Retinal 5TE5-Rhodopsin-20-Methanoretinal
38.46Consensusorexin_offOrthosteric Ligandox2_off ox1_off
37.50Single3UONQuinuclidinyl benzilate hydrobromide3UON-M2-Quinuclidinyl benzilate hydrobromide
37.50Single4DJHJDTic4DJH-κ-JDTic
37.50Single5X93K-87945X93-ETB-K-8794
37.50Single5ZHPPubChem 1348285895ZHP-M3-PubChem 134828589
37.50Single6GT3Imaradenant6GT3-A2A-Imaradenant-Na
37.50Single6J20Aprepitant6J20-NK1-Aprepitant
37.50Single6TQ7SB-3348676TQ7-OX1-SB-334867
37.50Single7EW1Siponimod7EW1-S1P5-Siponimod-Gi1/&β;1/&γ;2
37.50Single7M8W15r-Methyl-Prostaglandin D27M8W-DP2-15r-Methyl-Prostaglandin D2-Na
37.50Single7T2HLofentanil7T2H-μ-Lofentanil-Gi1/&β;1/&γ;2
37.50Single7TRQIperoxo7TRQ-M4-Iperoxo-VU0467154-Gi1/&β;1/&γ;2
37.50Single7U2LPubChem 1632012427U2L-μ-PubChem 163201242-Gi1/&β;1/&γ;2
37.50Single8EF5Fentanyl8EF5-μ-Fentanyl-Gi1/&β;1/&γ;2
37.50Single8EFLSR170188EFL-μ-SR17018-Gi1/&β;1/&γ;2
37.50Single8G056-OAU8G05-GPR84-6-OAU-Gi1/&β;1/&γ;2
37.50Single8HDOBAY 60-65838HDO-A2B-BAY 60-6583-Gs/&β;1/&γ;2
37.50Single8I9AEP548I9A-C3aB-EP54-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
37.50Single8ID39-Hydroxystearic acid8ID3-FFA4 (GPR120)-9-Hydroxystearic acid-Gi1/&β;1/&γ;2
37.50Single8JD0J9R8JD0-mGlu2; mGlu3-Glutamate-J9R
37.50Single8JXVClozapine8JXV-H4-Clozapine-Gi1/&β;1/&γ;2
37.50Single8JXWVUF68848JXW-H4-VUF6884-Gi1/&β;1/&γ;2
37.50Single8JXXClobenpropit8JXX-H4-Clobenpropit-Gi1/&β;1/&γ;2
37.50Consensus5ht1b_onOrthosteric Ligand6G79-5-HT1B-Donitriptan-Go/&β;1/&γ;2
37.50Consensusa2b_onOrthosteric Ligand8HDP-A2B-Adenosine-Gs/&β;1/&γ;2 8HDO-A2B-BAY 60-6583-Gs/&β;1/&γ;2 7XY7-A2B-NECA-chim(NtGi1-Gs)/&β;1/&γ;2 7XY6-A2B-PubChem 11717831-chim(NtGi1-Gs)/&β;1/&γ;2
37.50Consensusangiotensin_offOrthosteric Ligandat1_off at2_off
37.50Consensusgs_adenosineOrthosteric Ligand8HDP-A2B-Adenosine-Gs/&β;1/&γ;2 8HDO-A2B-BAY 60-6583-Gs/&β;1/&γ;2 6GDG-A2A-NECA-Gs/&β;1/&γ;1 7XY7-A2B-NECA-chim(NtGi1-Gs)/&β;1/&γ;2 7XY6-A2B-PubChem 11717831-chim(NtGi1-Gs)/&β;1/&γ;2
37.50Consensusgs_compl-peptideOrthosteric Ligand8I9A-C3aB-EP54-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
37.50Consensusgs_nucleotideOrthosteric Ligandgs_adenosine
37.50Consensuskop_offOrthosteric Ligand4DJH-κ-JDTic
37.50Consensuss1p3_onOrthosteric Ligand7EW3-S1P3-S1P-Gi1/&β;1/&γ;2 7EW4-S1P3-CYM5541-Gi1/&β;1/&γ;2 7EW2-S1P3-Fingolimod-Gi1/&β;1/&γ;2
37.50Consensuss1p5_onOrthosteric Ligand7EW1-S1P5-Siponimod-Gi1/&β;1/&γ;2
37.50Consensussst4_onOrthosteric Ligand7XMT-SST4-J-2156-Gi1/&β;1/&γ;2
36.84Single5UNFPubChem 157800525UNF-AT2-PubChem 15780052
36.84Single7WVWfMYFINILTL7WVW-FPR2-ALX-fMYFINILTL-Gi2/&β;1/&γ;2
36.84Single8G59TUG-8918G59-FFA4 (GPR120)-TUG-891-Gi1/&β;1/&γ;2
36.84Consensusgi_opioidOrthosteric Ligand8EF6-μ-Morphine-Gi1/&β;1/&γ;2 8F7Q-μ-Beta-endorphin-Gi1/&β;1/&γ;2 7U2K-μ-C6-guano-Gi1/&β;1/&γ;2 8EFQ-μ-Damgo-Gi1/&β;1/&γ;2 8F7S-δ-Deltorphin-Gi1/&β;1/&γ;2 8F7W-κ-Dynorphin-Gi1/&β;1/&γ;2 8F7R-μ-Endomorphin-Gi1/&β;1/&γ;2 8EF5-μ-Fentanyl-Gi1/&β;1/&γ;2 7SCG-μ-FH210-Gi1/&β;1/&γ;2 7T2H-μ-Lofentanil-Gi1/&β;1/&γ;2 7T2G-μ-Mitragynine pseudoindoxyl-Gi1/&β;1/&γ;2 8DZP-κ-momSalB-Gi1/&β;1/&γ;2 8F7X-NOP-Nociceptin-Gi1/&β;1/&γ;2 8EFB-μ-Oliceridine-Gi1/&β;1/&γ;2 8FEG-κ-PRD_002517-Gi1/&β;1/&γ;2 7U2L-μ-PubChem 163201242-Gi1/&β;1/&γ;2 8EFO-μ-PZM21-Gi1/&β;1/&γ;2 8EFL-μ-SR17018-Gi1/&β;1/&γ;2
36.36Single7MTBAll-trans-retinal7MTB-Rhodopsin-All-trans-retinal-GRK1
36.36Single8IWM2-Phenylethylamine8IWM-TAAR9-2-Phenylethylamine
36.36Single8WC5Tetramethylammonium ion8WC5-TA1-Tetramethylammonium ion-chim(NtGi1-Gs)/&β;1/&γ;2
36.36Consensusgq_class-aOrthosteric Ligandgq_amine gq_peptide
36.36Consensushca2_on_alloOrthosteric Ligand8J6P-HCA2-Niacin-Compound 9n-Gi1/&β;1/&γ;2 8J6Q-HCA2-Beta-hydroxybutyrate-Compound 9n-Gi1/&β;1/&γ;2
36.36Consensussensory_onOrthosteric Ligandopsin_on
35.71Single2YDOAdenosine2YDO-A2A-Adenosine
35.71Single3OAX11-cis-Retinal3OAX-Rhodopsin-11-cis-Retinal
35.71Single3RZECidoxepin3RZE-H1-Cidoxepin
35.71Single3UZCPubChem 1355666093UZC-A2A-PubChem 135566609
35.71Single3V2YPubChem 518926453V2Y-S1P1-PubChem 51892645
35.71Single4DKLBeta-funaltrexamine4DKL-μ-Beta-funaltrexamine
35.71Single4N6HNaltrindole4N6H-δ-Naltrindole-Na
35.71Single4ZJCSB-6740424ZJC-OX1-SB-674042
35.71Single5TE3Octyl Beta-D-Glucopyranoside5TE3-Rhodopsin-Octyl Beta-D-Glucopyranoside
35.71Single6DS0Ly2660976DS0-5-HT2B-Ly266097
35.71Single6VI4JDTic6VI4-κ-JDTic
35.71Single7CMVPD1289077CMV-D3-PD128907-Gi1/&β;1/&γ;2
35.71Single7EJ8Brimonidine7EJ8-α2a-Brimonidine-Go/&β;1/&γ;2
35.71Single7F1ZDopamine7F1Z-D1-Dopamine-GDP-Gs/&β;1/&γ;2
35.71Single7F61PF-036547467F61-H3-PF-03654746-Cholesterol
35.71Single7T32ZM2413857T32-A2A-ZM241385
35.71Single7T94Acetylcholine7T94-M2-Acetylcholine-PubChem 57664406-chim(NtGi1-Go)/&β;1/&γ;2
35.71Single7TRSAcetylcholine7TRS-M4-Acetylcholine-Gi1/&β;1/&γ;2
35.71Single7VODCariprazine7VOD-5-HT2A-Cariprazine
35.71Single7VUGJNJ-635330547VUG-GPR139-JNJ-63533054-Gi1/&β;1/&γ;2
35.71Single7WC9PubChem 1624213647WC9-5-HT2A-PubChem 162421364
35.71Single7ZBC11-cis-Retinal7ZBC-Rhodopsin-11-cis-Retinal
35.71Single7ZBE11-cis-Retinal7ZBE-Rhodopsin-11-cis-Retinal
35.71Single8DPGPsilocin8DPG-5-HT2C-Psilocin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
35.71Single8GURPubChem 1048958GUR-CB2-PubChem 104895-Gi1/&β;1/&γ;2
35.71Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
35.71Consensusdop_off_alloOrthosteric Ligand4N6H-δ-Naltrindole-Na
35.71Consensusgi_melatoninOrthosteric Ligand7VGY-MT1-2-Iodomelatonin-Gi1/&β;1/&γ;2 7DB6-MT1-Ramelteon-Gi1/&β;1/&γ;2 7VH0-MT2-Ramelteon-Gi1/&β;1/&γ;1
35.71Consensush3_on_alloOrthosteric Ligand7F61-H3-PF-03654746-Cholesterol
35.71Consensusox1_offOrthosteric Ligand6TOT-OX1-Lemborexant 6TP4-OX1-ACT-462206 6TP6-OX1-Filorexant 6V9S-OX1-GTPL11403 6TP3-OX1-Nemorexant 6TQ6-OX1-PubChem 145714283 6TQ7-OX1-SB-334867 6TQ9-OX1-SB-408124 4ZJC-OX1-SB-674042 4ZJ8-OX1-Suvorexant
35.71Consensuss1p1_offOrthosteric Ligand3V2Y-S1P1-PubChem 51892645
35.71Consensuss1p_offOrthosteric Ligands1p1_off
35.71Consensussensory_offOrthosteric Ligandopsin_off
35.29Single4OR2FITM4OR2-mGlu1; mGlu1-FITM
35.29Single6A93Risperidone6A93-5-HT2A-Risperidone
35.29Single6CM4Risperidone6CM4-D2-Risperidone
35.29Single7DFPSpiperone7DFP-D2-Spiperone
35.29Single7EW2Fingolimod7EW2-S1P3-Fingolimod-Gi1/&β;1/&γ;2
35.29Single7JNIOlodanrigan7JNI-AT2-Olodanrigan
35.29Single7L1VPubChem 1554910097L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
35.29Single7WCNAR2314537WCN-GPR119-AR231453-Gs/&β;1/&γ;2
35.29Single7X1TTaltirelin7X1T-TRH-Taltirelin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
35.29Single7XMTJ-21567XMT-SST4-J-2156-Gi1/&β;1/&γ;2
35.29Single7XY7NECA7XY7-A2B-NECA-chim(NtGi1-Gs)/&β;1/&γ;2
35.29Single8E9W2-Deoxycytidine8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
35.29Single8I95EP548I95-C3aB-EP54-Go/&β;1/&γ;2
35.29Single8IA8E7 peptide8IA8-C3aB-E7 peptide-Gi1/&β;1/&γ;2
35.29Single8IJDMK68928IJD-HCA2-MK6892-Gi1/&β;1/&γ;2
35.29Single8JWYPubChem 1684517108JWY-A2A-PubChem 168451710
35.29Single8JWZAB9288JWZ-A2A-AB928-Na
35.29Single8JZ7MK68928JZ7-HCA2-MK6892-Gi1/&β;1/&γ;2
35.29Single8T3QDHA8T3Q-FFA4-DHA-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
35.29Single8WU1KCA8WU1-CB1-KCA-Arrestin1
35.29Consensusat2_offOrthosteric Ligand7JNI-AT2-Olodanrigan
35.29Consensuscannabinoid_offOrthosteric Ligandcb1_off cb2_off
35.29Consensusgs_bileacidOrthosteric Ligand7CFN-GPBA-INT-777-Gs/&β;1/&γ;2 7CFM-GPBA-P395-Gs/&β;1/&γ;2 7XTQ-GPBA-R399-Gs/&β;1/&γ;2
35.29Consensusgs_steroidOrthosteric Ligandgs_bileacid
35.29Consensuslpa1_offOrthosteric Ligand4Z36-LPA1-ONO-3080573 4Z34-LPA1-ONO-9780307 4Z35-LPA1-ONO-9910539 7YU4-LPA1-ONO-0740556
35.00Single3QAKUK-4320973QAK-A2A-UK-432097
35.00Single6HLOAprepitant6HLO-NK1-Aprepitant
35.00Single8F7SDeltorphin8F7S-δ-Deltorphin-Gi1/&β;1/&γ;2
35.00Consensusgi_lplOrthosteric Ligand7EW3-S1P3-S1P-Gi1/&β;1/&γ;2 7TD4-S1P1-Siponimod-Gi1/&β;1/&γ;2 7VIF-S1P1-(S)-FTY720-P-Gi1/&β;1/&γ;2 7EO4-S1P1-BAF312-Gi1/&β;1/&γ;2 7VIG-S1P1-CBP-307-Gi1/&β;1/&γ;2 7EVZ-S1P1-Cenerimod-Gi1/&β;1/&γ;2 7EW4-S1P3-CYM5541-Gi1/&β;1/&γ;2 7EW2-S1P3-Fingolimod-Gi1/&β;1/&γ;2 7TD0-LPA1-LPA-Gi1/&β;1/&γ;2 7YU3-LPA1-ONO-0740556-Gi1/&β;1/&γ;2 7EW0-S1P1-Ozanimod-Gi1/&β;1/&γ;2 7EW7-S1P1-PubChem 4077460-Gi1/&β;1/&γ;2
34.78Consensuskop_onOrthosteric Ligand8F7W-κ-Dynorphin-Gi1/&β;1/&γ;2 8DZR-κ-GR89,696-chim(NtGi2-Gt3)/&β;1/&γ;2 8DZP-κ-momSalB-Gi1/&β;1/&γ;2 8FEG-κ-PRD_002517-Gi1/&β;1/&γ;2
33.33Single2J4Y11-cis-Retinal2J4Y-Rhodopsin-11-cis-Retinal
33.33Single3C9M11-cis-Retinal3C9M-Rhodopsin-11-cis-Retinal
33.33Single3UZAGTPL92363UZA-A2A-GTPL9236
33.33Single4EA3PubChem 102965614EA3-NOP-PubChem 10296561
33.33Single4J4QOctyl Beta-D-Glucopyranoside4J4Q-Rhodopsin-Octyl Beta-D-Glucopyranoside-Gt(CT)
33.33Single4OR2FITM4OR2-mGlu1; mGlu1-FITM
33.33Single4X1HNonyl Beta-D-Glucopyranoside4X1H-Rhodopsin-Nonyl Beta-D-Glucopyranoside-Gt(CT)
33.33Single4Z35ONO-99105394Z35-LPA1-ONO-9910539
33.33Single5DSGTiotropium5DSG-M4-Tiotropium
33.33Single5OLZPubChem 1355666095OLZ-A2A-PubChem 135566609-Na
33.33Single5OM1PubChem 1355666095OM1-A2A-PubChem 135566609-Na
33.33Single5UIGJ3.651.884G5UIG-A2A-J3.651.884G
33.33Single5WF5UK-4320975WF5-A2A-UK-432097
33.33Single5WKTOctyl Beta-D-Glucopyranoside5WKT-Rhodopsin-Octyl Beta-D-Glucopyranoside-Gt(CT)
33.33Single6ME5Agomelatine6ME5-MT1-Agomelatine
33.33Single6ME9Ramelteon6ME9-MT2-Ramelteon
33.33Single6PT2KGCHM076PT2-δ-KGCHM07
33.33Single6TOTLemborexant6TOT-OX1-Lemborexant
33.33Single6WHADB139486WHA-5-HT2A-DB13948-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
33.33Single7DB6Ramelteon7DB6-MT1-Ramelteon-Gi1/&β;1/&γ;2
33.33Single7EPFNAM5977EPF-mGlu2; mGlu2-NAM597
33.33Single7EVZCenerimod7EVZ-S1P1-Cenerimod-Gi1/&β;1/&γ;2
33.33Single7EW0Ozanimod7EW0-S1P1-Ozanimod-Gi1/&β;1/&γ;2
33.33Single7EZCUKA7EZC-A2A-UKA
33.33Single7F23Dopamine7F23-D1-Dopamine-GDP-Gs/&β;1/&γ;2
33.33Single7MTSADX551647MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/&β;1/&γ;2
33.33Single7SK7CCX6627SK7-ACKR3-CXCL12-CCX662
33.33Single7TD0LPA7TD0-LPA1-LPA-Gi1/&β;1/&γ;2
33.33Single7VIES1P7VIE-S1P1-S1P-Gi1/&β;1/&γ;2
33.33Single7WC5Psilocin7WC5-5-HT2A-Psilocin
33.33Single7WC8Lumateperone7WC8-5-HT2A-Lumateperone
33.33Single7WVVfMLFII7WVV-FPR2-ALX-fMLFII-Gi2/&β;1/&γ;2
33.33Single7XK2MK68927XK2-HCA2-MK6892-Gi1/&β;1/&γ;2
33.33Single7XZ6APD6687XZ6-GPR119-APD668-Gs/&β;1/&γ;2
33.33Single8CU6LJ-45178CU6-A2A-LJ-4517
33.33Single8CU7LJ-45178CU7-A2A-LJ-4517-Na
33.33Single8GAGYVF8GAG-CB1-YVF-Gi1/&β;1/&γ;2
33.33Single8IW72-Phenylethylamine8IW7-TAAR9-2-Phenylethylamine-chim(NtGi1-Gs)/&β;1/&γ;2
33.33Single8J6QBeta-hydroxybutyrate8J6Q-HCA2-Beta-hydroxybutyrate-Compound 9n-Gi1/&β;1/&γ;2
33.33Single8JXTHistamine8JXT-H4-Histamine-PO4-Gi1/&β;1/&γ;2
33.33Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/&β;1/&γ;2
33.33Single8T3OTUG-8918T3O-FFA4-TUG-891-2Y5-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
33.33Single8X17Namodenoson8X17-A3A-Namodenoson-Gi1/&β;1/&γ;2
33.33Consensusadenosine_onOrthosteric Liganda1_on a2_on
33.33Consensusangiotensin_onOrthosteric Ligandat1_on
33.33Consensusat1_onOrthosteric Ligand7F6G-AT1-SAR1-AngII-Gq/&β;1/&γ;2
33.33Consensusbileacid_onOrthosteric Ligand7CFN-GPBA-INT-777-Gs/&β;1/&γ;2 7CFM-GPBA-P395-Gs/&β;1/&γ;2 7XTQ-GPBA-R399-Gs/&β;1/&γ;2
33.33Consensusffa4_on_alloOrthosteric Ligand8T3O-FFA4-TUG-891-2Y5-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
33.33Consensusgi_hcaOrthosteric Ligand8H2G-HCA2-Niacin-Gi1/&β;1/&γ;2 8IHJ-HCA3-Acifran-Gi1/&β;1/&γ;2 8IHI-HCA2-Acifran-Gi1/&β;1/&γ;2 8IHB-HCA2-GSK256073-Gi1/&β;1/&γ;2 8IHH-HCA2-LUF6283-Gi1/&β;1/&γ;2 8IHF-HCA2-MK6892-Gi1/&β;1/&γ;2 8JIM-HCA2-MMF-Gi1/&β;1/&γ;2 8IJB-HCA2-Acipimox-Gi1/&β;1/&γ;2 8IJD-HCA2-MK6892-Gi1/&β;1/&γ;2
33.33Consensusgi_hcarOrthosteric Ligandgi_hca
33.33Consensusgs_class-aOrthosteric Ligandgs_amine gs_nucleotide gs_lipid gs_peptide gs_protein gs_steroid
33.33Consensusgs_orexinOrthosteric Ligand7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7SR8-OX2-TAK-925-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
33.33Consensushca2_onOrthosteric Ligand8H2G-HCA2-Niacin-Gi1/&β;1/&γ;2 8IHI-HCA2-Acifran-Gi1/&β;1/&γ;2 8IHH-HCA2-LUF6283-Gi1/&β;1/&γ;2 8IHF-HCA2-MK6892-Gi1/&β;1/&γ;2 8JHY-HCA2-Compound 9n-Gi1/&β;1/&γ;2 8IHB-HCA2-GSK256073-Gi1/&β;1/&γ;2 8JIM-HCA2-MMF-Gi1/&β;1/&γ;2 8IJB-HCA2-Acipimox-Gi1/&β;1/&γ;2 8IJD-HCA2-MK6892-Gi1/&β;1/&γ;2 8J6J-HCA2-GSK256073-Gi1/&β;1/&γ;2
33.33Consensusm2_on_alloOrthosteric Ligand7T94-M2-Acetylcholine-PubChem 57664406-chim(NtGi1-Go)/&β;1/&γ;2 6OIK-M2-Iperoxo-LY2119620-chim(NtGi1-Go)/&β;1/&γ;2
33.33Consensusm4_offOrthosteric Ligand5DSG-M4-Tiotropium
33.33Consensusmuscarinic_onOrthosteric Ligandm2_on m3_on m4_on m1_on
33.33Consensusnucleotide_onOrthosteric Ligandadenosine_on
33.33Consensusopioid_onOrthosteric Ligandkop_on mop_on nop_on dop_on
33.33Consensusopsin_onOrthosteric Ligand6OYA-Rhodopsin-All-trans-retinal-Gt/&β;1/&γ;1
33.33Consensusorexin_onOrthosteric Ligandox2_on
33.33Consensuss1p1_onOrthosteric Ligand7TD3-S1P1-S1P-Gi1/&β;1/&γ;2 7TD4-S1P1-Siponimod-Gi1/&β;1/&γ;2 7VIF-S1P1-(S)-FTY720-P-Gi1/&β;1/&γ;2 7EO4-S1P1-BAF312-Gi1/&β;1/&γ;2 7VIG-S1P1-CBP-307-Gi1/&β;1/&γ;2 7EVZ-S1P1-Cenerimod-Gi1/&β;1/&γ;2 7EW0-S1P1-Ozanimod-Gi1/&β;1/&γ;2 7EW7-S1P1-PubChem 4077460-Gi1/&β;1/&γ;2
33.33Consensussteroid_onOrthosteric Ligandbileacid_on
33.33Consensustachykinin_offOrthosteric Ligandnk1_off
31.82Single7DW9Acyclovir triphosphate7DW9-V2-Acyclovir triphosphate-chim(NtGi1-Gs)/&β;1/&γ;2
31.82Single7F6GSAR1-AngII7F6G-AT1-SAR1-AngII-Gq/&β;1/&γ;2
31.82Single7W40Bombesin7W40-BB2-Bombesin-chim(NtGi1L-Gq)/&β;1/&γ;2
31.82Single8H4KGW95088H4K-FFA4-GW9508-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
31.82Consensusgq_angiotensinOrthosteric Ligand7F6G-AT1-SAR1-AngII-Gq/&β;1/&γ;2
31.82Consensusv2_onOrthosteric Ligand7DW9-V2-Acyclovir triphosphate-chim(NtGi1-Gs)/&β;1/&γ;2
31.58Single5WF6UK-4320975WF6-A2A-UK-432097
31.58Single5ZTYAM102575ZTY-CB2-AM10257
31.58Single7XN9L-054,5227XN9-SST2-L-054,522
31.58Single8F7REndomorphin8F7R-μ-Endomorphin-Gi1/&β;1/&γ;2
31.58Consensuscb2_offOrthosteric Ligand5ZTY-CB2-AM10257
31.58Consensusdop_onOrthosteric Ligand8F7S-δ-Deltorphin-Gi1/&β;1/&γ;2
31.58Consensusgi_lipidOrthosteric Ligandgi_cannabinoid gi_prostanoid gi_ffa gi_lpl gi_leukotriene
31.58Consensuslpl_offOrthosteric Ligands1p_off lpa_off
31.58Consensuslpl_onOrthosteric Ligands1p_on lpa_on
31.58Consensusox2_onOrthosteric Ligand7L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7SR8-OX2-TAK-925-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
31.25Single4WW3All-trans-retinal4WW3-Rhodopsin-All-trans-retinal
31.25Single4ZJ8Suvorexant4ZJ8-OX1-Suvorexant
31.25Single5NM2ZM2413855NM2-A2A-ZM241385-Na
31.25Single5OM4PubChem 1355666095OM4-A2A-PubChem 135566609-Na
31.25Single6D26Fevipiprant6D26-DP2-Fevipiprant
31.25Single6GDGNECA6GDG-A2A-NECA-Gs/&β;1/&γ;1
31.25Single6OIKIperoxo6OIK-M2-Iperoxo-LY2119620-chim(NtGi1-Go)/&β;1/&γ;2
31.25Single6TO7Suvorexant6TO7-OX1-Suvorexant-Na
31.25Single7C4SS1P7C4S-S1P3-S1P
31.25Single7EO2FTY720-P7EO2-S1P1-FTY720-P-Gi1/&β;1/&γ;2
31.25Single7EUOfMLF7EUO-FPR1-ALX-fMLF-Gi1/&β;1/&γ;2
31.25Single7TD3S1P7TD3-S1P1-S1P-Gi1/&β;1/&γ;2
31.25Single7VFXfMLF7VFX-FPR1-ALX-fMLF-Gi1/&β;1/&γ;2
31.25Single8IHJAcifran8IHJ-HCA3-Acifran-Gi1/&β;1/&γ;2
31.25Single8J6JGSK2560738J6J-HCA2-GSK256073-Gi1/&β;1/&γ;2
31.25Single8KFXLMD-0098KFX-CCR8-LMD-009-Gi1/&β;1/&γ;2
31.25Single8SZGCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-chim(NtGi1-Gq)/&β;1/&γ;2
31.25Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
31.25Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
31.25Consensusa2a_onOrthosteric Ligand6GDG-A2A-NECA-Gs/&β;1/&γ;1
31.25Consensuscb2_onOrthosteric Ligand8GUS-CB2-HU-308-Gi1/&β;1/&γ;2 8GUT-CB2-LEI-102-Gi1/&β;1/&γ;2 8GUQ-CB2-Olorinab-Gi1/&β;1/&γ;2 8GUR-CB2-PubChem 104895-Gi1/&β;1/&γ;2 6KPF-CB2-PubChem 145915889-Gi1/&β;1/&γ;2 6PT0-CB2-WIN 55212-2-Gi1/&β;1/&γ;2
31.25Consensusgq_muscarinicOrthosteric Ligand6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/&β;1/&γ;2
31.25Consensusm1_onOrthosteric Ligand6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/&β;1/&γ;2
30.77Single1L9H11-cis-Retinal1L9H-Rhodopsin-11-cis-Retinal
30.77Single1U1911-cis-Retinal1U19-Rhodopsin-11-cis-Retinal
30.77Single2G87All-trans-retinal2G87-Rhodopsin-All-trans-retinal
30.77Single2I3511-cis-Retinal2I35-Rhodopsin-11-cis-Retinal
30.77Single5OLVLUAA410635OLV-A2A-LUAA41063-Na
30.77Single5TE520-Methanoretinal5TE5-Rhodopsin-20-Methanoretinal
30.77Single6I9K9-cis-Retinal6I9K-Rhodopsin-9-cis-Retinal
30.77Single6TQ4PubChem 160468446TQ4-OX1-PubChem 16046844-Na
30.77Single7V68Iperoxo7V68-M4-Iperoxo-PubChem 57664406-Gi1/&β;1/&γ;2
30.77Single7YFDImetit7YFD-H4-Imetit-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
30.77Single8A2PLUAA470708A2P-A2A-LUAA47070-Na
30.77Single8H2GNiacin8H2G-HCA2-Niacin-Gi1/&β;1/&γ;2
30.77Single8HN8Histamine8HN8-H4-Histamine-Gi1/&β;1/&γ;2
30.77Single8IJANiacin8IJA-HCA2-Niacin-Gi1/&β;1/&γ;2
30.77Single8ITFDMCHA8ITF-TAAR9-DMCHA-chim(NtGi1-Gs)/&β;1/&γ;2
30.77Single8IY9Niacin8IY9-HCA2-Niacin-Go/&β;1/&γ;2
30.77Single8K5BNiacin8K5B-HCA2-Niacin
30.77Consensusmt1_onOrthosteric Ligand7VGY-MT1-2-Iodomelatonin-Gi1/&β;1/&γ;2 7DB6-MT1-Ramelteon-Gi1/&β;1/&γ;2
30.77Consensusox1_off_alloOrthosteric Ligand6TOD-OX1-EMPA-Na 6TOS-OX1-GSK1059865-Na 6TQ4-OX1-PubChem 16046844-Na 6TO7-OX1-Suvorexant-Na
30.43Single7KH0Acyclovir triphosphate7KH0-V2-Acyclovir triphosphate-chim(NtGi1-Gs)/&β;1/&γ;2
30.43Single7YKDChemerin-97YKD-CML1-Chemerin-9-Gi1/&β;1/&γ;2
30.00Single5MZPCaffeine5MZP-A2A-Caffeine-Na
30.00Single7W0PElabela7W0P-Apelin-Elabela-Gi1/&β;1/&γ;2
30.00Single7WKDTRH7WKD-TRH-TRH-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
30.00Single8F7XNociceptin8F7X-NOP-Nociceptin-Gi1/&β;1/&γ;2
30.00Single8J6RMK68928J6R-HCA2-MK6892-Gi1/&β;1/&γ;2
30.00Single8WCBCyclohexylammonium ion8WCB-TA1-Cyclohexylammonium ion-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
30.00Single8WCCCyclohexylammonium ion8WCC-TA1-Cyclohexylammonium ion
30.00Consensusalpha1a_offOrthosteric Ligand7YMJ-Alpha1A-Tamsulosin 8HN1-Alpha1A-Toxin AdTx1
30.00Consensusapelin_onOrthosteric Ligand7W0P-Apelin-Elabela-Gi1/&β;1/&γ;2 7W0M-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
30.00Consensusnop_onOrthosteric Ligand8F7X-NOP-Nociceptin-Gi1/&β;1/&γ;2
29.41Single4Z34ONO-97803074Z34-LPA1-ONO-9780307
29.41Single5XR8AM8415XR8-CB1-AM841
29.41Single6E59L-7607356E59-NK1-L-760735
29.41Single6KO5PubChem 574000026KO5-Ghrelin-PubChem 57400002
29.41Single6OIJIperoxo6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/&β;1/&γ;2
29.41Single7EPENAM5637EPE-mGlu-NAM563
29.41Single7EW4CYM55417EW4-S1P3-CYM5541-Gi1/&β;1/&γ;2
29.41Single7EW7PubChem 40774607EW7-S1P1-PubChem 4077460-Gi1/&β;1/&γ;2
29.41Single7TD1LPA7TD1-LPA1-LPA-Gi1/&β;1/&γ;2
29.41Single7TUYGSK682753A7TUY-GPR183-GSK682753A
29.41Single7VIGCBP-3077VIG-S1P1-CBP-307-Gi1/&β;1/&γ;2
29.41Single7W41PD1762527W41-BB2-PD176252
29.41Single7WVXHumanin7WVX-FPR2-ALX-Humanin-Gi2/&β;1/&γ;2
29.41Single7XTQR3997XTQ-GPBA-R399-Gs/&β;1/&γ;2
29.41Single8HPTC5a anaphylatoxin C-terminal peptide8HPT-C5a1-C5a anaphylatoxin C-terminal peptide-Go/&β;1/&γ;2
29.41Single8ID6Oleic acid8ID6-FFA4 (GPR120)-Oleic acid-Gi1/&β;1/&γ;2
29.41Single8IHBGSK2560738IHB-HCA2-GSK256073-Gi1/&β;1/&γ;2
29.41Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/&β;1/&γ;2
29.41Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
29.41Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/&β;1/&γ;2
29.41Consensusadenosine_offOrthosteric Liganda1_off a2_off
29.41Consensusarrestin2Orthosteric Ligand6TKO-β1-Arformoterol-Arrestin2 6PWC-NTS1-Neurotensin-Arrestin2 7R0C-V2-Acyclovir triphosphate-Arrestin2
29.41Consensusbb2_offOrthosteric Ligand7W41-BB2-PD176252
29.41Consensusbombesin_offOrthosteric Ligandbb2_off
29.41Consensusclass-a_offOrthosteric Ligandsensory_off amine_off lipid_off nucleotide_off peptide_off protein_off hcar_off
29.41Consensusffa4_onOrthosteric Ligand8H4K-FFA4-GW9508-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8ID9-FFA4 (GPR120)-Eicosapentaenoic acid-Gi1/&β;1/&γ;2 8ID4-FFA4 (GPR120)-Linoleic acid-Gi1/&β;1/&γ;2 8ID6-FFA4 (GPR120)-Oleic acid-Gi1/&β;1/&γ;2 8G59-FFA4 (GPR120)-TUG-891-Gi1/&β;1/&γ;2 8ID3-FFA4 (GPR120)-9-Hydroxystearic acid-Gi1/&β;1/&γ;2 8H4I-FFA4-Doconexent-chim(NtGi1-Gs)/&β;1/&γ;2
29.41Consensusgi_muscarinicOrthosteric Ligand7TRS-M4-Acetylcholine-Gi1/&β;1/&γ;2 7TRK-M4-Iperoxo-Gi1/&β;1/&γ;2 7V6A-M4-PubChem 9864275-Gi1/&β;1/&γ;2
29.41Consensuslpa1_onOrthosteric Ligand7TD0-LPA1-LPA-Gi1/&β;1/&γ;2 7YU3-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
29.41Consensuslpa_offOrthosteric Ligandlpa1_off
29.41Consensuslpa_onOrthosteric Ligandlpa1_on
29.17Consensusgs_vasopressin-otOrthosteric Ligand7RYC-OT-Oxytocin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 7DW9-V2-Acyclovir triphosphate-chim(NtGi1-Gs)/&β;1/&γ;2
28.57Single1F8811-cis-Retinal1F88-Rhodopsin-11-cis-Retinal
28.57Single5DHHSB-6121115DHH-NOP-SB-612111
28.57Single5K2DZM2413855K2D-A2A-ZM241385
28.57Single5OLHVipadenant5OLH-A2A-Vipadenant-Na
28.57Single5OLOTozadenant5OLO-A2A-Tozadenant-Na
28.57Single5WS3EMPA5WS3-OX2-EMPA
28.57Single6B73PubChem 1319551386B73-κ-PubChem 131955138
28.57Single6D9HAdenosine6D9H-A1-Adenosine-Gi2/&β;1/&γ;2
28.57Single6DO1Angiotensin-Like peptide S1I86DO1-AT1-Angiotensin-Like peptide S1I8
28.57Single6JZHZM2413856JZH-A2A-ZM241385-Na
28.57Single6OYAAll-trans-retinal6OYA-Rhodopsin-All-trans-retinal-Gt/&β;1/&γ;1
28.57Single6PS7ZM2413856PS7-A2A-ZM241385-Na
28.57Single6TQ6PubChem 1457142836TQ6-OX1-PubChem 145714283
28.57Single7DDZJNJ-310200287DDZ-Y2-JNJ-31020028
28.57Single7F8ULintitript7F8U-CCKA-Lintitript
28.57Single7M3ECa; Ca; Tryptophan; NPS-2143; PO47M3E-CaS-Ca; Ca; Tryptophan; NPS-2143; PO4
28.57Single7M3ECa; Ca; Tryptophan; NPS-2143; PO47M3E-CaS-Ca; Ca; Tryptophan; NPS-2143; PO4
28.57Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
28.57Single7TUZ7alpha,25-dihydroxycholesterol7TUZ-GPR183-7alpha,25-dihydroxycholesterol-Gi1/&β;1/&γ;2
28.57Single7VIHCBP-3077VIH-S1P1-CBP-307-Gi1/&β;1/&γ;2
28.57Single7VUJJNJ-635330547VUJ-GPR139-JNJ-63533054-GDP-chim(Gs-CtGq)/&β;1/&γ;2
28.57Single7WF7S1P7WF7-S1P1-S1P-Gi1/&β;1/&γ;2
28.57Single7XRRLemborexant7XRR-OX2-Lemborexant
28.57Single8A6CAll-trans-retinal8A6C-Rhodopsin-All-trans-retinal
28.57Single8A6DAll-trans-retinal8A6D-Rhodopsin-All-trans-retinal
28.57Single8A6EAll-trans-retinal8A6E-Rhodopsin-All-trans-retinal
28.57Single8DU3PubChem 1055260648DU3-A2A-PubChem 105526064
28.57Single8F7WDynorphin8F7W-κ-Dynorphin-Gi1/&β;1/&γ;2
28.57Single8GNGIstradefylline8GNG-A2A-Istradefylline
28.57Single8IHKAcifran8IHK-HCA3-Acifran
28.57Single8SG1Chemerin-98SG1-CML1-Chemerin-9-Gi1/&β;1/&γ;2
28.57Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
28.57Consensusa2a_off_alloOrthosteric Ligand6ZDR-A2A-HMS1413f12-Na 6GT3-A2A-Imaradenant-Na 8CU7-A2A-LJ-4517-Na 5OLV-A2A-LUAA41063-Na 5N2R-A2A-PubChem 92460631; psb36-Na 5MZJ-A2A-Theophylline-Na 5OLO-A2A-Tozadenant-Na 5OLH-A2A-Vipadenant-Na 5NM4-A2A-ZM241385-Na 8GNE-A2A-KW-6356-Na 8JWZ-A2A-AB928-Na 5MZP-A2A-Caffeine-Na 8CIC-A2A-Etrumadenant-Na
28.57Consensusgt_class-aOrthosteric Ligandgt_opsin
28.57Consensusgt_opsinOrthosteric Ligandgt_sensory
28.57Consensusgt_sensoryOrthosteric Ligand6OYA-Rhodopsin-All-trans-retinal-Gt/&β;1/&γ;1
28.57Consensusnpy2_offOrthosteric Ligand7DDZ-Y2-JNJ-31020028
27.78Single4Z36ONO-30805734Z36-LPA1-ONO-3080573
27.78Single6HLPNetupitant6HLP-NK1-Netupitant
27.78Single6OS0Angiotensinogen6OS0-AT1-Angiotensinogen
27.78Single6W2YPubChem 237279706W2Y-GABAB1; GABAB1-PubChem 5311042-PubChem 23727970
27.78Single6ZG4HTL00099366ZG4-M1-HTL0009936
27.78Single7EO4BAF3127EO4-S1P1-BAF312-Gi1/&β;1/&γ;2
27.78Single7EVYSiponimod7EVY-S1P1-Siponimod-Gi1/&β;1/&γ;2
27.78Single7W0LPubChem 1227019087W0L-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
27.78Single7WCMMBX-29827WCM-GPR119-MBX-2982-Gs/&β;1/&γ;2
27.78Single7XW9TRH7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
27.78Single7Y24Octreotide7Y24-SST2-Octreotide-Go/&β;1/&γ;2
27.78Single8I9LC3a anaphylatoxin8I9L-C3aB-C3a anaphylatoxin-Go/&β;1/&γ;2
27.78Consensuscannabinoid_onOrthosteric Ligandcb1_on cb2_on
27.78Consensuscb1_onOrthosteric Ligand8GHV-CB1-PubChem 145964903-Gi1/&β;1/&γ;2 6KPG-CB1-AM841-Gi1/&β;1/&γ;2 6N4B-CB1-MDMB-Fubinaca-Gi1/&β;1/&γ;2
27.78Consensusdp2_offOrthosteric Ligand6D27-DP2-CAY10471 6D26-DP2-Fevipiprant
27.78Consensusdp_offOrthosteric Liganddp2_off
27.78Consensusgi_cannabinoidOrthosteric Ligand8GUS-CB2-HU-308-Gi1/&β;1/&γ;2 8GUT-CB2-LEI-102-Gi1/&β;1/&γ;2 8GUQ-CB2-Olorinab-Gi1/&β;1/&γ;2 8GUR-CB2-PubChem 104895-Gi1/&β;1/&γ;2 6KPF-CB2-PubChem 145915889-Gi1/&β;1/&γ;2 6PT0-CB2-WIN 55212-2-Gi1/&β;1/&γ;2 6KPG-CB1-AM841-Gi1/&β;1/&γ;2 6N4B-CB1-MDMB-Fubinaca-Gi1/&β;1/&γ;2 8GHV-CB1-PubChem 145964903-Gi1/&β;1/&γ;2
27.78Consensusgpr119_onOrthosteric Ligand7XZ6-GPR119-APD668-Gs/&β;1/&γ;2 7WCN-GPR119-AR231453-Gs/&β;1/&γ;2 7XZ5-GPR119-Lysophosphatidylcholine-Gs/&β;1/&γ;2 7WCM-GPR119-MBX-2982-Gs/&β;1/&γ;2
27.78Consensusgs_trhOrthosteric Ligand7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
27.78Consensusm4_onOrthosteric Ligand7TRS-M4-Acetylcholine-Gi1/&β;1/&γ;2 7TRK-M4-Iperoxo-Gi1/&β;1/&γ;2 8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/&β;1/&γ;2 7V6A-M4-PubChem 9864275-Gi1/&β;1/&γ;2
27.78Consensuspeptide_offOrthosteric Ligandopioid_off angiotensin_off bombesin_off cck_off endothelin_off ghrelin_off npy_off nts_off orexin_off vasopressin-ot_off tachykinin_off sst_off
27.78Consensuss1p_onOrthosteric Ligands1p3_on s1p5_on s1p1_on s1p2_on
27.78Consensustrh_onOrthosteric Ligand7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
27.27Single3PXOAll-trans-retinal3PXO-Rhodopsin-All-trans-retinal
27.27Single5DYSAll-trans-retinal5DYS-Rhodopsin-All-trans-retinal
27.27Single5MZJTheophylline5MZJ-A2A-Theophylline-Na
27.27Single7T6TfMLFII7T6T-FPR1-ALX-fMLFII-Gi1/&β;1/&γ;2
27.27Single7TD2LPA7TD2-LPA1-LPA-Gi1/&β;1/&γ;2
27.27Single8PWNTheophylline8PWN-A2A-Theophylline
27.27Consensusgi_chemerinOrthosteric Ligand8SG1-CML1-Chemerin-9-Gi1/&β;1/&γ;2
27.27Consensusgi_formylpeptideOrthosteric Ligand7VFX-FPR1-ALX-fMLF-Gi1/&β;1/&γ;2 7T6T-FPR1-ALX-fMLFII-Gi1/&β;1/&γ;2 7WVY-FPR2-ALX-Amyloid-Beta42-Gi2/&β;1/&γ;2 7T6U-FPR2-ALX-CGEN-855A-Gi1/&β;1/&γ;2 7WVV-FPR2-ALX-fMLFII-Gi2/&β;1/&γ;2 7WVW-FPR2-ALX-fMYFINILTL-Gi2/&β;1/&γ;2 7WVX-FPR2-ALX-Humanin-Gi2/&β;1/&γ;2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/&β;1/&γ;2 6OMM-FPR2-ALX-WKYMVX-Gi1/&β;1/&γ;2
26.92Consensusgq_peptideOrthosteric Ligandgq_cck gq_angiotensin gq_bombesin gq_bradykinin
26.92Consensuspeptide_onOrthosteric Ligandopioid_on angiotensin_on bombesin_on cck_on endothelin_on ghrelin_on npy_on nts_on orexin_on vasopressin-ot_on tachykinin_on sst_on relaxin_on trh_on nmur_on motilin_on melanocortin_on galanin_on fpr-alx_on compl-peptide_on bradykinin_on apelin_on
26.67Single3REYPubChem 56973REY-A2A-PubChem 5697
26.67Single5IU4ZM2413855IU4-A2A-ZM241385-Na
26.67Single5IU7Q274563465IU7-A2A-Q27456346-Na
26.67Single5IUBQ274563445IUB-A2A-Q27456344-Na
26.67Single5JTBZM2413855JTB-A2A-ZM241385
26.67Single5K2BZM2413855K2B-A2A-ZM241385-Na
26.67Single5K2CZM2413855K2C-A2A-ZM241385-Na
26.67Single5NLXZM2413855NLX-A2A-ZM241385-Na
26.67Single5NM4ZM2413855NM4-A2A-ZM241385-Na
26.67Single6AQFZM2413856AQF-A2A-ZM241385
26.67Single6IQLL7458706IQL-D4-L745870
26.67Single6TOSGSK10598656TOS-OX1-GSK1059865-Na
26.67Single6TP3Nemorexant6TP3-OX1-Nemorexant
26.67Single6V9SGTPL114036V9S-OX1-GTPL11403
26.67Single6ZDRHMS1413f126ZDR-A2A-HMS1413f12-Na
26.67Single6ZDVPubChem 9840736ZDV-A2A-PubChem 984073-Na
26.67Single6ZFZ77-LH-28-16ZFZ-M1-77-LH-28-1
26.67Single7AROLUF58337ARO-A2A-LUF5833-Na
26.67Single7EJADexmedetomidine7EJA-α2a-Dexmedetomidine-Go/&β;1/&γ;2
26.67Single7WVUfMLF7WVU-FPR1-ALX-fMLF-Gi1/&β;1/&γ;2
26.67Single8DWGML3828DWG-MRGPRX1-Proenkephalin-A-ML382-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
26.67Single8GUQOlorinab8GUQ-CB2-Olorinab-Gi1/&β;1/&γ;2
26.67Single8HNMVUF112228HNM-CXCR3-VUF11222-Gi1/&β;1/&γ;2
26.67Single8J6PNiacin8J6P-HCA2-Niacin-Compound 9n-Gi1/&β;1/&γ;2
26.67Single8JERAcipimox8JER-HCA2-Acipimox-Go/&β;1/&γ;2
26.67Single8JHNMMF8JHN-HCA2-MMF-Go/&β;1/&γ;2
26.67Single8JIMMMF8JIM-HCA2-MMF-Gi1/&β;1/&γ;2
26.67Single8K5CAcipimox8K5C-HCA2-Acipimox
26.67Consensusat1_offOrthosteric Ligand4YAY-AT1-ZD-7155 4ZUD-AT1-Olmesartan
26.67Consensushca_onOrthosteric Ligandhca2_on hca3_on
26.67Consensushcar_onOrthosteric Ligandhca_on
26.67Consensusnop_offOrthosteric Ligand4EA3-NOP-PubChem 10296561 5DHG-NOP-PubChem 25001412 5DHH-NOP-SB-612111
26.32Single6K1QIRL25006K1Q-ETB-IRL2500
26.32Single7XAVLanreotide7XAV-SST2-Lanreotide-Gi1/&β;1/&γ;2
26.32Single7Y65C5a peptide7Y65-C5a1-C5a peptide-Gi1/&β;1/&γ;2
26.32Single7YU8ONO-07405567YU8-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
26.32Single8GUTLEI-1028GUT-CB2-LEI-102-Gi1/&β;1/&γ;2
26.32Single8ID8TUG-8918ID8-FFA4 (GPR120)-TUG-891-Gi1/&β;1/&γ;2
26.32Single8IYSTUG-8918IYS-FFA4-TUG-891-GDP-chim(NtGi1L-Gq)/&β;1/&γ;2
26.32Single8JD3HZR; PEF8JD3-mGlu2; mGlu3-Glutamate-HZR; PEF-Gi1/&β;1/&γ;2
26.32Single8K2XCXCL108K2X-CXCR3-CXCL10-Gi1/&β;1/&γ;2
26.09Single6JODAngiotensin II6JOD-AT2-Angiotensin II
26.09Single6WI9Secretin6WI9-Secretin-Secretin-Gs/&β;1/&γ;2
26.09Single8IHFMK68928IHF-HCA2-MK6892-Gi1/&β;1/&γ;2
26.09Single8J6IMK68928J6I-HCA2-MK6892-Gi1/&β;1/&γ;2
25.93Consensusbb2_onOrthosteric Ligand7W40-BB2-Bombesin-chim(NtGi1L-Gq)/&β;1/&γ;2 7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/&β;1/&γ;2
25.93Consensusgi_peptideOrthosteric Ligandgi_opioid gi_endothelin gi_formylpeptide gi_galanin gi_ghrelin gi_neuromedin gi_neurotensin gi_relaxin gi_neuropeptide gi_somatostatin gi_apelin gi_compl-peptide gi_cck
25.93Consensusgq_bombesinOrthosteric Ligand7W40-BB2-Bombesin-chim(NtGi1L-Gq)/&β;1/&γ;2 7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/&β;1/&γ;2
25.00Single3EMLZM2413853EML-A2A-ZM241385
25.00Single3RFMCaffeine3RFM-A2A-Caffeine
25.00Single4EIYZM2413854EIY-A2A-ZM241385-Na
25.00Single4YAYZD-71554YAY-AT1-ZD-7155
25.00Single4ZUDOlmesartan4ZUD-AT1-Olmesartan
25.00Single5DHGPubChem 250014125DHG-NOP-PubChem 25001412
25.00Single5EE7MK08935EE7-Glucagon-MK0893
25.00Single5IU8Q274563475IU8-A2A-Q27456347-Na
25.00Single5K2AZM2413855K2A-A2A-ZM241385-Na
25.00Single5OLGZM2413855OLG-A2A-ZM241385-Na
25.00Single5UENDU1725UEN-A1-DU172
25.00Single5VRAZM2413855VRA-A2A-ZM241385-Na
25.00Single5ZKPForopafant (SR27417)5ZKP-PAF-Foropafant (SR27417)
25.00Single6D27CAY104716D27-DP2-CAY10471
25.00Single6KPFPubChem 1459158896KPF-CB2-PubChem 145915889-Gi1/&β;1/&γ;2
25.00Single6LPJZM2413856LPJ-A2A-ZM241385-Na
25.00Single6LPKZM2413856LPK-A2A-ZM241385-Na
25.00Single6OY9All-trans-retinal6OY9-Rhodopsin-All-trans-retinal-Gt/&β;1/&γ;1
25.00Single6S0LZM2413856S0L-A2A-ZM241385
25.00Single6TQ9SB-4081246TQ9-OX1-SB-408124
25.00Single7CFMP3957CFM-GPBA-P395-Gs/&β;1/&γ;2
25.00Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
25.00Single7M3JNPS-2143; PO47M3J-CaS-NPS-2143; PO4
25.00Single7MTRADX551647MTR-mGlu2; mGlu2-Glutamate-ADX55164
25.00Single7PYRPSB-21157PYR-A2A-PSB-2115
25.00Single7V3ZPubMed 1048957V3Z-CB1-PubMed 104895
25.00Single7VIF(S)-FTY720-P7VIF-S1P1-(S)-FTY720-P-Gi1/&β;1/&γ;2
25.00Single7VKTLTB47VKT-BLT1-LTB4-Gi1/&β;1/&γ;2
25.00Single7X1UTRH7X1U-TRH-TRH-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
25.00Single7YJ4INSL57YJ4-RXFP4-INSL5-Gi2/&β;1/&γ;2
25.00Single7YU4ONO-07405567YU4-LPA1-ONO-0740556
25.00Single8A2OTheophylline8A2O-A2A-Theophylline-Na
25.00Single8I7VAcipimox8I7V-HCA2-Acipimox-Gi1/&β;1/&γ;2
25.00Single8I7WGSK2560738I7W-HCA2-GSK256073-Gi1/&β;1/&γ;2
25.00Single8IA7Cholecystokinin-88IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/&β;1/&γ;2
25.00Single8ID4Linoleic acid8ID4-FFA4 (GPR120)-Linoleic acid-Gi1/&β;1/&γ;2
25.00Single8IYHMK68928IYH-HCA2-MK6892-Go/&β;1/&γ;2
25.00Single8JIINiacin8JII-HCA2-Niacin-Compound 9n-Gi1/&β;1/&γ;2
25.00Single8JT8(R)-IHCH-71798JT8-5-HT2A-(R)-IHCH-7179
25.00Single8K5DGSK2560738K5D-HCA2-GSK256073
25.00Consensusa2_offOrthosteric Liganda2a_off
25.00Consensusa2a_offOrthosteric Ligand8C9W-A2A-Etrumadenant 3UZA-A2A-GTPL9236 8GNG-A2A-Istradefylline 5UIG-A2A-J3.651.884G 8CU6-A2A-LJ-4517 7PX4-A2A-PSB-2113 7PYR-A2A-PSB-2115 8DU3-A2A-PubChem 105526064 8JWY-A2A-PubChem 168451710 5K2D-A2A-ZM241385
25.00Consensusbk1_onOrthosteric Ligand7EIB-BK1-Des-Arg10-Kallidin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
25.00Consensusblt1_onOrthosteric Ligand7VKT-BLT1-LTB4-Gi1/&β;1/&γ;2
25.00Consensusblt_onOrthosteric Ligandblt1_on
25.00Consensusbombesin_onOrthosteric Ligandbb2_on bb1_on
25.00Consensusc3a_onOrthosteric Ligand8HK2-C3aB-C3a anaphylatoxin-Gi1/&β;1/&γ;2 8IA8-C3aB-E7 peptide-Gi1/&β;1/&γ;2 8J6D-C3aB-EP141-Go/&β;1/&γ;2 8I95-C3aB-EP54-Go/&β;1/&γ;2
25.00Consensuscb1_on_alloOrthosteric Ligand7WV9-CB1-PubMed 104895-ZCZ011-Gi2/&β;1/&γ;2
25.00Consensusfpr1-alx_onOrthosteric Ligand7VFX-FPR1-ALX-fMLF-Gi1/&β;1/&γ;2 7T6T-FPR1-ALX-fMLFII-Gi1/&β;1/&γ;2
25.00Consensusfpr2-alx_onOrthosteric Ligand7WVY-FPR2-ALX-Amyloid-Beta42-Gi2/&β;1/&γ;2 7T6U-FPR2-ALX-CGEN-855A-Gi1/&β;1/&γ;2 7WVV-FPR2-ALX-fMLFII-Gi2/&β;1/&γ;2 7WVW-FPR2-ALX-fMYFINILTL-Gi2/&β;1/&γ;2 7WVX-FPR2-ALX-Humanin-Gi2/&β;1/&γ;2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/&β;1/&γ;2 6OMM-FPR2-ALX-WKYMVX-Gi1/&β;1/&γ;2
25.00Consensusgi_apelinOrthosteric Ligand7W0P-Apelin-Elabela-Gi1/&β;1/&γ;2 7W0M-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
25.00Consensusgi_leukotrieneOrthosteric Ligand7VKT-BLT1-LTB4-Gi1/&β;1/&γ;2
25.00Consensushca3_onOrthosteric Ligand8IHJ-HCA3-Acifran-Gi1/&β;1/&γ;2
25.00Consensusleuko_onOrthosteric Ligandblt_on
25.00Consensusnucleotide_offOrthosteric Ligandadenosine_off p2y_off
24.14Single6LRYSarafotoxin-B6LRY-ETB-Sarafotoxin-B
24.00Single7F8VGastrin-177F8V-CCKB-Gastrin-17-Gi2/&β;1/&γ;2
24.00Single7RGPTirzepatide7RGP-GLP-1-Tirzepatide-chim(NtGi1-Gs)/&β;1/&γ;2
24.00Single8H0PNMB308H0P-BB1-NMB30-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
24.00Consensusbb1_onOrthosteric Ligand8H0P-BB1-NMB30-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
23.81Single7F4ISHU91197F4I-MC1-SHU9119-chim(NtGi1-Gs)/&β;1/&γ;2
23.81Single7F8XNN90567F8X-CCKA-NN9056
23.81Single7TD4Siponimod7TD4-S1P1-Siponimod-Gi1/&β;1/&γ;2
23.81Single7WICSomatostatin-147WIC-SST2-Somatostatin-14-Gi1/&β;1/&γ;2
23.81Single8GHVPubChem 1459649038GHV-CB1-PubChem 145964903-Gi1/&β;1/&γ;2
23.81Single8JZZC5a-desArg8JZZ-C5a1-C5a-desArg-Go/&β;1/&γ;2
23.81Consensusfpr-alx_onOrthosteric Ligandfpr1-alx_on fpr2-alx_on
23.81Consensusgo_class-aOrthosteric Ligandgo_amine go_peptide go_protein
23.81Consensussst_onOrthosteric Ligandsst2_on sst4_on
23.53Single5CGCHTL142425CGC-mGlu5-HTL14242
23.53Single5IUAQ274563485IUA-A2A-Q27456348-Na
23.53Single5N2RPubChem 92460631; psb365N2R-A2A-PubChem 92460631; psb36-Na
23.53Single5N2SPSB365N2S-A1-PSB36
23.53Single6KPCPubChem 1459158896KPC-CB2-PubChem 145915889
23.53Single6LPLZM2413856LPL-A2A-ZM241385-Na
23.53Single6S0QZM2413856S0Q-A2A-ZM241385
23.53Single6WQAZM2413856WQA-A2A-ZM241385-Na
23.53Single7BB7Acyclovir triphosphate7BB7-V2-Acyclovir triphosphate-Gs/&β;1/&γ;2
23.53Single7M3JNPS-2143; PO47M3J-CaS-NPS-2143; PO4
23.53Single7RM5ZM2413857RM5-A2A-ZM241385-Na
23.53Single7SINNPS-21437SIN-CaS-NPS-2143
23.53Single7SINNPS-21437SIN-CaS-NPS-2143
23.53Single7VUHJNJ-635330547VUH-GPR139-JNJ-63533054-chim(Gs-CtGq)/&β;1/&γ;2
23.53Single7WIGL-054,2647WIG-SST2-L-054,264-Gi1/&β;1/&γ;2
23.53Single7YU3ONO-07405567YU3-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
23.53Single7YU6ONO-07405567YU6-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
23.53Single7YU7ONO-07405567YU7-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
23.53Single8FYNZM2413858FYN-A2A-ZM241385-Na
23.53Single8GNEKW-63568GNE-A2A-KW-6356-Na
23.53Single8ID9Eicosapentaenoic acid8ID9-FFA4 (GPR120)-Eicosapentaenoic acid-Gi1/&β;1/&γ;2
23.53Single8K8JFenofibrate8K8J-CB1-Fenofibrate-chim(Gs-CtGq)/&β;1/&γ;2
23.53Single8QOTNanobody E8QOT-μ-Nanobody E
23.53Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/&β;1/&γ;2
23.53Consensusa1_offOrthosteric Ligand5UEN-A1-DU172 5N2S-A1-PSB36
23.33Consensusnpy1_onOrthosteric Ligand7X9A-Y1-Neuropeptide Y-Gi1/&β;1/&γ;2
23.08Single3PQRAll-trans-retinal3PQR-Rhodopsin-All-trans-retinal-Gt(CT)
23.08Single7EIBDes-Arg10-Kallidin7EIB-BK1-Des-Arg10-Kallidin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
23.08Single7F4FAfamelanotide7F4F-MC1-Afamelanotide-chim(NtGi1-Gs)/&β;1/&γ;2
23.08Single7MT8All-trans-retinal7MT8-Rhodopsin-All-trans-retinal-GRK1
23.08Single7MT9All-trans-retinal7MT9-Rhodopsin-All-trans-retinal-GRK1
23.08Single7MTAAll-trans-retinal7MTA-Rhodopsin-All-trans-retinal-GRK1
23.08Single7WVYAmyloid-Beta427WVY-FPR2-ALX-Amyloid-Beta42-Gi2/&β;1/&γ;2
23.08Single8EITDoconexent8EIT-FFA1 (GPR40)-Doconexent-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
23.08Single8F76-8F76-OR51E2-Gs/&β;1/&γ;2
23.08Single8IU2Retinal8IU2-Opsin1LW-Retinal-Gi1/&β;1/&γ;2
23.08Single8J21Butyric acid8J21-FFA3-Butyric acid-Gi1/&β;1/&γ;2
23.08Single8J24Acetic acid8J24-FFA2-Acetic acid-Gi1/&β;1/&γ;2
23.08Consensusendothelin_onOrthosteric Ligandetb_on eta_on
23.08Consensusffa3_onOrthosteric Ligand8J21-FFA3-Butyric acid-Gi1/&β;1/&γ;2
23.08Consensusgo_class-b1Orthosteric Ligandgo_crf
23.08Consensusgo_crfOrthosteric Ligand7TS0-CRF2-Urocortin-chim(NtGi1L-Go)/&β;1/&γ;2
22.73Single5XJM(Sar1,Ile8)-Angiotensin II5XJM-AT2-(Sar1,Ile8)-Angiotensin II
22.73Single7CUMPhospholipid7CUM-GABAB1, GABAB2-CGP54626-Phospholipid
22.73Single7EZKCholecystokinin-87EZK-CCKA-Cholecystokinin-8-chim(NtGi1-Gs)/&β;1/&γ;2
22.73Single7WJ5Somatostatin-147WJ5-SST2-Somatostatin-14-Gi1/&β;1/&γ;2
22.73Single7XMSSomatostatin-147XMS-SST4-Somatostatin-14-Gi1/&β;1/&γ;2
22.73Consensusgi_cckOrthosteric Ligand7EZH-CCKA-Cholecystokinin-8-Gi1/&β;1/&γ;2 7F8V-CCKB-Gastrin-17-Gi2/&β;1/&γ;2
22.22Single5XRAAM115425XRA-CB1-AM11542
22.22Single6B3JExendin-P56B3J-GLP-1-Exendin-P5-Gs/&β;1/&γ;2
22.22Single6IGLIRL16206IGL-ETB-IRL1620
22.22Single7PX4PSB-21137PX4-A2A-PSB-2113
22.22Single7VGXNeuropeptide Y7VGX-Y1-Neuropeptide Y-Gi1/&β;1/&γ;2
22.22Single7WV9PubMed 1048957WV9-CB1-PubMed 104895-ZCZ011-Gi2/&β;1/&γ;2
22.22Single7YU5ONO-07405567YU5-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
22.22Single8FEGPRD_0025178FEG-κ-PRD_002517-Gi1/&β;1/&γ;2
22.22Single8GUSHU-3088GUS-CB2-HU-308-Gi1/&β;1/&γ;2
22.22Single8IHHLUF62838IHH-HCA2-LUF6283-Gi1/&β;1/&γ;2
22.22Single8IY5Endothelin-18IY5-ETB-Endothelin-1-Gi1/&β;1/&γ;2
22.22Single8IYWGSK2560738IYW-HCA2-GSK256073-Go/&β;1/&γ;2
22.22Single8X16Piclidenoson8X16-A3A-Piclidenoson-Gi1/&β;1/&γ;2
22.22Single8XJMLatanoprost8XJM-FP-alpha-Latanoprost-chim(NtGi2-Gs-CtGq)/&β;1/&γ;2
22.22Consensuscck_onOrthosteric Ligandccka_on cckb_on
22.22Consensusccka_onOrthosteric Ligand7EZH-CCKA-Cholecystokinin-8-Gi1/&β;1/&γ;2 7XOV-CCKA-SR146131-Gs/&β;1/&γ;2
22.22Consensuschemerin_onOrthosteric Ligandcml1_on
22.22Consensuscml1_onOrthosteric Ligand8SG1-CML1-Chemerin-9-Gi1/&β;1/&γ;2
22.22Consensuscyslt1_off_ortoalloOrthosteric Ligand6RZ5-CysLT1-Zafirlukast-Na 6RZ4-CysLT1-Pranlukast-Na
22.22Consensusgi_ffaOrthosteric Ligand8ID6-FFA4 (GPR120)-Oleic acid-Gi1/&β;1/&γ;2 8G59-FFA4 (GPR120)-TUG-891-Gi1/&β;1/&γ;2 8ID3-FFA4 (GPR120)-9-Hydroxystearic acid-Gi1/&β;1/&γ;2 8ID9-FFA4 (GPR120)-Eicosapentaenoic acid-Gi1/&β;1/&γ;2 8ID4-FFA4 (GPR120)-Linoleic acid-Gi1/&β;1/&γ;2 8J22-FFA2-TUG-1375-Gi1/&β;1/&γ;2 8J24-FFA2-Acetic acid-Gi1/&β;1/&γ;2 8J21-FFA3-Butyric acid-Gi1/&β;1/&γ;2
22.22Consensusgq_bradykininOrthosteric Ligand7F6H-BK2-Bradykinin-Gq/&β;1/&γ;2 7F6I-BK2-Kallidin-Gq/&β;1/&γ;2
22.22Consensusgs_endothelinOrthosteric Ligand8HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8HCX-ETB-Endothelin-1-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
22.22Consensusgs_ffaOrthosteric Ligand8EIT-FFA1 (GPR40)-Doconexent-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2 8EJC-FFA1 (GPR40)-TAK-875-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2 8H4K-FFA4-GW9508-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8T3V-FFA1-DHA-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8T3S-FFA2-Butyric acid-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8T3Q-FFA4-DHA-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8GD9-EP4-Rivenprost-Gs/&β;1/&γ;2 8GDA-EP4-L902688-Gs/&β;1/&γ;2 8GDB-EP4-PGE2-Gs/&β;1/&γ;2
22.22Consensusgs_peptideOrthosteric Ligandgs_cck gs_motilin gs_neuromedin gs_orexin gs_sst gs_tachykinin gs_trh gs_vasopressin-ot gs_bombesin gs_bradykinin gs_compl-peptide gs_endothelin gs_galanin gs_ghrelin gs_melanocortin
22.22Consensusnpy1_offOrthosteric Ligand5ZBH-Y1-BMS-193885 5ZBQ-Y1-UR-MK-299
22.22Consensusnpy_offOrthosteric Ligandnpy2_off npy1_off
21.74Single6VN7PACAP6VN7-VPAC1-PACAP-Gs/&β;1/&γ;2
21.74Single7MBXCholecystokinin-87MBX-CCKA-Cholecystokinin-8-Gs/&β;1/&γ;1
21.43Single3AYMAll-trans-retinal3AYM-Rhodopsin-All-trans-retinal
21.43Single3OE9IT1t3OE9-CXCR4-IT1t
21.43Single3V2WPubChem 518926453V2W-S1P1-PubChem 51892645
21.43Single5GLHEndothelin-15GLH-ETB-Endothelin-1
21.43Single6IGKEndothelin-36IGK-ETB-Endothelin-3
21.43Single6PB0Urocortin6PB0-CRF1-Urocortin-chim(NtGi1-Gs)/&β;1/&γ;2
21.43Single6PGSGeraniol6PGS-Rhodopsin-Geraniol-Gt(CT)
21.43Single6QNOAll-trans-retinal6QNO-Rhodopsin-All-trans-retinal-Gi1/&β;1/&γ;1
21.43Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
21.43Single7TS0Urocortin7TS0-CRF2-Urocortin-chim(NtGi1L-Go)/&β;1/&γ;2
21.43Single7VUIJNJ-635330547VUI-GPR139-JNJ-63533054-GTP-chim(Gs-CtGq)/&β;1/&γ;2
21.43Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
21.05Single6XBLCholesterol6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
21.05Single7K15MKD0467K15-BLT1-MKD046-Na
21.05Single7L1UOrexin7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
21.05Single7SUSPubChem 1227019087SUS-Apelin-PubChem 122701908
21.05Single7W0LPubChem 1227019087W0L-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
21.05Single7XZ5Lysophosphatidylcholine7XZ5-GPR119-Lysophosphatidylcholine-Gs/&β;1/&γ;2
21.05Single8J22TUG-13758J22-FFA2-TUG-1375-Gi1/&β;1/&γ;2
21.05Single8J6DEP1418J6D-C3aB-EP141-Go/&β;1/&γ;2
21.05Consensusblt1_offOrthosteric Ligand7K15-BLT1-MKD046-Na
21.05Consensusblt_offOrthosteric Ligandblt1_off
21.05Consensusgi_class-fOther Ligandgi_frizzled
21.05Consensusgi_frizzledOther Ligand6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
21.05Consensusleuko_offOrthosteric Ligandblt_off cyslt_off
20.83Single6WIVPubChem 52923113; PubChem 529246456WIV-GABAB1, GABAB2-PubChem 52923113; PubChem 52924645
20.83Single7FIMTirzepatide7FIM-GLP-1-Tirzepatide-Gs/&β;1/&γ;2
20.83Single7RYCOxytocin7RYC-OT-Oxytocin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
20.83Single8HNKCXCL118HNK-CXCR3-CXCL11-Gi1/&β;1/&γ;2
20.83Consensusgi_somatostatinOrthosteric Ligand7XMR-SST2-Somatostatin-14-Gi1/&β;1/&γ;2 7XMT-SST4-J-2156-Gi1/&β;1/&γ;2 7XAU-SST2-Octreotide-Gi1/&β;1/&γ;2 7YAC-SST2-Paltusotine-Gi1/&β;1/&γ;2
20.69Single6LPBPACAP6LPB-PAC1-PACAP-Gs/&β;1/&γ;1
20.69Single8HBDIRL16208HBD-ETB-IRL1620-Gi1/&β;1/&γ;2
20.69Consensusgi_endothelinOrthosteric Ligand8IY5-ETB-Endothelin-1-Gi1/&β;1/&γ;2 8HBD-ETB-IRL1620-Gi1/&β;1/&γ;2
20.00Single2Z7311-cis-Retinal2Z73-Rhodopsin-11-cis-Retinal
20.00Single3AYN9-cis-Retinal3AYN-Rhodopsin-9-cis-Retinal
20.00Single3PWHZM2413853PWH-A2A-ZM241385
20.00Single3VG9ZM2413853VG9-A2A-ZM241385-Antibody
20.00Single4S0VSuvorexant4S0V-OX2-Suvorexant
20.00Single5CGDHTL142425CGD-mGlu5-HTL14242
20.00Single6TPJSuvorexant6TPJ-OX2-Suvorexant
20.00Single6UUNAdrenomedullin6UUN-CT Like (AM1)-Adrenomedullin-Gs/&β;1/&γ;2; RAMP2
20.00Single7EZHCholecystokinin-87EZH-CCKA-Cholecystokinin-8-Gi1/&β;1/&γ;2
20.00Single7EZMCholecystokinin-87EZM-CCKA-Cholecystokinin-8-chim(NtGsL-Gq)/&β;1/&γ;2
20.00Single7F6HBradykinin7F6H-BK2-Bradykinin-Gq/&β;1/&γ;2
20.00Single7LLLExendin-47LLL-GLP-1-Exendin-4-Gs/&β;1/&γ;2
20.00Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
20.00Single7MBYCholecystokinin-87MBY-CCKA-Cholecystokinin-8-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
20.00Single7QBIAlpha-factor mating pheromone7QBI-STE2-Alpha-factor mating pheromone
20.00Single7V9MSomatoliberin7V9M-GHRH (SV1)-Somatoliberin-Gs/&β;1/&γ;2
20.00Single7W0MPubChem 1227019087W0M-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
20.00Single7W0OElabela7W0O-Apelin-Elabela-Gi1/&β;1/&γ;2
20.00Single7X8RBOC57X8R-GLP-1-BOC5-Gs/&β;1/&γ;2
20.00Single7X9BNeuropeptide Y7X9B-Y2-Neuropeptide Y-Gi1/&β;1/&γ;2
20.00Single7X9CPancreatic Hormone7X9C-Y4-Pancreatic Hormone-Gi1/&β;1/&γ;2
20.00Single7XATSomatostatin-147XAT-SST2-Somatostatin-14-Gi1/&β;1/&γ;2
20.00Single7Y64C5a anaphylatoxin7Y64-C5a1-C5a anaphylatoxin-Gi1/&β;1/&γ;2
20.00Single8E3YPACAP278E3Y-VPAC1-PACAP27-Gs/&β;1/&γ;2
20.00Single8E3ZVIP8E3Z-VPAC1-VIP-Gs/&β;1/&γ;2
20.00Single8HCXEndothelin-18HCX-ETB-Endothelin-1-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
20.00Single8HN1Toxin AdTx18HN1-Alpha1A-Toxin AdTx1
20.00Single8IJBAcipimox8IJB-HCA2-Acipimox-Gi1/&β;1/&γ;2
20.00Single8IODPG-9018IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
20.00Single8IULLatanoprost8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
20.00Single8J20Valeric acid8J20-FFA3-Valeric acid-AR420626-Gi1/&β;1/&γ;2
20.00Single8J6LNiacin8J6L-HCA2-Niacin-Gi1/&β;1/&γ;2
20.00Single8SZGCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-chim(NtGi1-Gq)/&β;1/&γ;2
20.00Single8T3SButyric acid8T3S-FFA2-Butyric acid-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
20.00Single8WRZ8D08WRZ-CB1-8D0-Arrestin1
20.00Consensusc5a1_onOrthosteric Ligand7Y65-C5a1-C5a peptide-Gi1/&β;1/&γ;2 8HK5-C5a1-Complement C5-Gi1/&β;1/&γ;2 7Y66-C5a1-BM213-Gi1/&β;1/&γ;2 7Y67-C5a1-C089 peptide-Gi1/&β;1/&γ;2 7Y64-C5a1-C5a anaphylatoxin-Gi1/&β;1/&γ;2
20.00Consensuscckb_onOrthosteric Ligand7XOW-CCKB-Gastrin-Gq/&β;1/&γ;2 7F8W-CCKB-Gastrin-17-chim(NtGsL-Gq)/&β;1/&γ;2 8IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/&β;1/&γ;2
20.00Consensusffa3_on_alloOrthosteric Ligand8J20-FFA3-Valeric acid-AR420626-Gi1/&β;1/&γ;2
20.00Consensusfpa_onOrthosteric Ligand8IUK-FP-alpha-PGF2-alpha-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
20.00Consensusgs_bradykininOrthosteric Ligand7F2O-BK2-Bradykinin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7EIB-BK1-Des-Arg10-Kallidin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
20.00Consensusgs_cckOrthosteric Ligand7MBX-CCKA-Cholecystokinin-8-Gs/&β;1/&γ;1 7XOV-CCKA-SR146131-Gs/&β;1/&γ;2
20.00Consensusmc1_onOrthosteric Ligand7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/&β;1/&γ;2 7F4D-MC1-Alpha-MSH-chim(NtGi1-Gs)/&β;1/&γ;2 7F4I-MC1-SHU9119-chim(NtGi1-Gs)/&β;1/&γ;2
20.00Consensusmglu_onOther Ligandmglu2_on mglu4_on
20.00Consensusot_onOrthosteric Ligand7QVM-OT-Oxytocin-chim(NtGi1-Go-CtGq)/&β;1/&γ;2
19.35Single7X9ANeuropeptide Y7X9A-Y1-Neuropeptide Y-Gi1/&β;1/&γ;2
19.35Consensusgi_neuropeptideOrthosteric Ligand7YOO-Y2-Neuropeptide Y-Gi1/&β;1/&γ;2 7YON-Y2-Peptide YY(3-36)-Gi1/&β;1/&γ;2 7X9C-Y4-Pancreatic Hormone-Gi1/&β;1/&γ;2 7X9A-Y1-Neuropeptide Y-Gi1/&β;1/&γ;2
19.35Consensusnpy_onOrthosteric Ligandnpy2_on npy4_on npy1_on
19.23Single6P9YPACAP6P9Y-PAC1-PACAP-Gs/&β;1/&γ;2
19.23Single7QBIAlpha-factor mating pheromone7QBI-STE2-Alpha-factor mating pheromone
19.23Single7VABNon-Acylated Tirzepatide7VAB-GIP-Non-Acylated Tirzepatide-chim(NtGi1-Gs)/&β;1/&γ;2
19.23Single8E3XPACAP278E3X-PAC1-PACAP27-Gs/&β;1/&γ;2
19.23Consensusbradykinin_onOrthosteric Ligandbk2_on bk1_on
19.23Consensusclass-d_onOrthosteric Ligandste2_on
19.23Consensusgi_compl-peptideOrthosteric Ligand8HK5-C5a1-Complement C5-Gi1/&β;1/&γ;2 8IA8-C3aB-E7 peptide-Gi1/&β;1/&γ;2 7Y66-C5a1-BM213-Gi1/&β;1/&γ;2 7Y67-C5a1-C089 peptide-Gi1/&β;1/&γ;2 8HK2-C3aB-C3a anaphylatoxin-Gi1/&β;1/&γ;2 7Y64-C5a1-C5a anaphylatoxin-Gi1/&β;1/&γ;2 7Y65-C5a1-C5a peptide-Gi1/&β;1/&γ;2
19.23Consensusnpy2_onOrthosteric Ligand7YOO-Y2-Neuropeptide Y-Gi1/&β;1/&γ;2 7YON-Y2-Peptide YY(3-36)-Gi1/&β;1/&γ;2
19.23Consensusnpy4_onOrthosteric Ligand7X9C-Y4-Pancreatic Hormone-Gi1/&β;1/&γ;2
19.05Single6OMMWKYMVX6OMM-FPR2-ALX-WKYMVX-Gi1/&β;1/&γ;2
19.05Single6XBJCholesterol6XBJ-SMO-Cholesterol-Gi1/&β;1/&γ;2
19.05Single7F2OBradykinin7F2O-BK2-Bradykinin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
19.05Single7F8WGastrin-177F8W-CCKB-Gastrin-17-chim(NtGsL-Gq)/&β;1/&γ;2
19.05Single7RKFFractalkine7RKF-US28-Fractalkine-GDP-chim(NtGi1-G11)/&β;1/&γ;2
19.05Single7Y1FDynorphin7Y1F-κ-Dynorphin-Gi1/&β;1/&γ;2
19.05Single7YAEOctreotide7YAE-SST2-Octreotide-Gi1/&β;1/&γ;2
19.05Single8H4IDoconexent8H4I-FFA4-Doconexent-chim(NtGi1-Gs)/&β;1/&γ;2
19.05Single8IUMTafluprost acid8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
19.05Single8XZFWN5618XZF-Apelin-WN561-Gi1/&β;1/&γ;2
19.05Consensusclass-d_offOrthosteric Ligandste2_off
19.05Consensusgo_compl-peptideOrthosteric Ligand8I95-C3aB-EP54-Go/&β;1/&γ;2 8IA2-C5a1-C5a anaphylatoxin-Go/&β;1/&γ;2 8I9L-C3aB-C3a anaphylatoxin-Go/&β;1/&γ;2 8J6D-C3aB-EP141-Go/&β;1/&γ;2
19.05Consensusgo_vasopressinOrthosteric Ligand7QVM-OT-Oxytocin-chim(NtGi1-Go-CtGq)/&β;1/&γ;2
19.05Consensusgq_cckOrthosteric Ligand8IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/&β;1/&γ;2 7F8W-CCKB-Gastrin-17-chim(NtGsL-Gq)/&β;1/&γ;2 7EZM-CCKA-Cholecystokinin-8-chim(NtGsL-Gq)/&β;1/&γ;2 7XOW-CCKB-Gastrin-Gq/&β;1/&γ;2
19.05Consensusgs_bombesinOrthosteric Ligand8H0Q-BB2-Gastrin Releasing Peptide-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8H0P-BB1-NMB30-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
19.05Consensusste2_offOrthosteric Ligand7QA8-STE2-Peptide
18.75Single5UVIZM2413855UVI-A2A-ZM241385
18.75Single6MH8ZM2413856MH8-A2A-ZM241385
18.75Single6PELCitronellol6PEL-Rhodopsin-Citronellol-Gt(CT)
18.75Single6PT0WIN 55212-26PT0-CB2-WIN 55212-2-Gi1/&β;1/&γ;2
18.75Single6TPKRetosiban6TPK-OT-Retosiban
18.75Single6ZG9GSK10347026ZG9-M1-GSK1034702
18.75Single7BB6Acyclovir triphosphate7BB6-V2-Acyclovir triphosphate-Gs/&β;1/&γ;2
18.75Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
18.75Single7YK6PubChem 1383196747YK6-RXFP4-PubChem 138319674-Gi2/&β;1/&γ;2
18.75Single8H4LDoconexent8H4L-FFA4-Doconexent-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
18.75Single8HQN9(S)-HODE8HQN-GPR132-9(S)-HODE-Gi1/&β;1/&γ;2
18.75Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
18.75Consensuscb1_offOrthosteric Ligand5TGZ-CB1-AM6538 5U09-CB1-Taranabant
18.75Consensusffa2_onOrthosteric Ligand8J24-FFA2-Acetic acid-Gi1/&β;1/&γ;2 8T3S-FFA2-Butyric acid-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8J22-FFA2-TUG-1375-Gi1/&β;1/&γ;2
18.75Consensusghrelin_offOrthosteric Ligand6KO5-Ghrelin-PubChem 57400002 7F83-Ghrelin-PF-05190457
18.75Consensusot_offOrthosteric Ligand6TPK-OT-Retosiban
18.75Consensuspth_onOrthosteric Ligandpth1_on pth2_on
18.75Consensusvasopressin-ot_offOrthosteric Ligandot_off
18.52Single6P9XCorticoliberin6P9X-CRF1-Corticoliberin-Gs/&β;1/&γ;2
18.52Single6VCBGLP-16VCB-GLP-1-GLP-1-LSN3160440-Gs/&β;1/&γ;2
18.52Single7AD3Alpha-factor mating pheromone7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
18.52Single7F53Alpha-MSH7F53-MC4-Alpha-MSH-Gs/&β;1/&γ;2
18.52Single7QBCAlpha-factor mating pheromone7QBC-STE2-Alpha-factor mating pheromone
18.52Single7YOONeuropeptide Y7YOO-Y2-Neuropeptide Y-Gi1/&β;1/&γ;2
18.52Consensusetb_onOrthosteric Ligand8HCX-ETB-Endothelin-1-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8HBD-ETB-IRL1620-Gi1/&β;1/&γ;2
18.52Consensusgi_class-dOrthosteric Ligandgi_ste
18.52Consensusgi_proteinOrthosteric Ligandgi_chemokine gi_chemerin
18.52Consensusgi_steOrthosteric Ligand7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
18.52Consensusgs_cgrpOrthosteric Ligand6E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/&β;1/&γ;2; RAMP1 6UUN-CT Like (AM1)-Adrenomedullin-Gs/&β;1/&γ;2; RAMP2
18.18Single4A4MAll-trans-retinal4A4M-Rhodopsin-All-trans-retinal-Gt(CT)
18.18Single4XT1Fractalkine4XT1-US28-Fractalkine
18.18Single5EN0All-trans-retinal5EN0-Rhodopsin-All-trans-retinal-Gt(CT)
18.18Single6WIVPubChem 52923113; PubChem 529246456WIV-GABAB1, GABAB2-PubChem 52923113; PubChem 52924645
18.18Single7QA8Peptide7QA8-STE2-Peptide
18.18Single7QA8Peptide7QA8-STE2-Peptide
18.18Single7T6UCGEN-855A7T6U-FPR2-ALX-CGEN-855A-Gi1/&β;1/&γ;2
18.18Consensusclass-d_offOrthosteric Ligandste2_off
18.18Consensusgi_ghrelinOrthosteric Ligand7NA7-Ghrelin-Ghrelin-27-Gi1/&β;1/&γ;2 7NA8-Ghrelin-PubChem 178024-Gi1/&β;1/&γ;2
18.18Consensusgi_relaxinOrthosteric Ligand7YK7-RXFP4-DC591053-Gi2/&β;1/&γ;2 7YJ4-RXFP4-INSL5-Gi2/&β;1/&γ;2 7YK6-RXFP4-PubChem 138319674-Gi2/&β;1/&γ;2
18.18Consensussst2_onOrthosteric Ligand7XMR-SST2-Somatostatin-14-Gi1/&β;1/&γ;2 7XAU-SST2-Octreotide-Gi1/&β;1/&γ;2 7YAC-SST2-Paltusotine-Gi1/&β;1/&γ;2
18.18Consensusste2_offOrthosteric Ligand7QA8-STE2-Peptide
17.86Single6LMLGlucagon6LML-Glucagon-Glucagon
17.86Single6WZGSecretin6WZG-Secretin-Secretin-Gs/&β;1/&γ;2
17.86Single7D68GLP-27D68-GLP-2-GLP-2-Gs/&β;1/&γ;2
17.86Single7KI1Taspoglutide7KI1-GLP-1-Taspoglutide-Gs/&β;1/&γ;2
17.86Single7QBCAlpha-factor mating pheromone7QBC-STE2-Alpha-factor mating pheromone
17.86Consensuscrf1_onOrthosteric Ligand6P9X-CRF1-Corticoliberin-Gs/&β;1/&γ;2
17.86Consensuscrf_onOrthosteric Ligandcrf2_on crf1_on
17.65Single5NDDAZ8838; Na5NDD-PAR2-AZ8838; Na
17.65Single5TGZAM65385TGZ-CB1-AM6538
17.65Single6GPSMK08126GPS-CCR2-MK0812
17.65Single6XBM25(S)-Epoxycholesterol6XBM-SMO-25(S)-Epoxycholesterol-Gi1/&β;1/&γ;2
17.65Single6Z10PubChem 1545855546Z10-Succinate-PubChem 154585554
17.65Single7E9GJNJ-404118137E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/&β;1/&γ;2
17.65Single7F16TIP397F16-PTH2-TIP39-Gs/&β;1/&γ;2
17.65Single7F83PF-051904577F83-Ghrelin-PF-05190457
17.65Single7PP1Selatogrel7PP1-P2Y12-Selatogrel
17.65Single7YK7DC5910537YK7-RXFP4-DC591053-Gi2/&β;1/&γ;2
17.65Single8KFYZK-7563268KFY-CCR8-ZK-756326-Gi1/&β;1/&γ;2
17.65Consensuscck_offOrthosteric Ligandccka_off
17.65Consensusccka_offOrthosteric Ligand7F8Y-CCKA-Devazepide 7F8U-CCKA-Lintitript
17.65Consensusffa_onOrthosteric Ligandffa4_on ffa1_on ffa2_on ffa3_on
17.65Consensusfsh_on_alloOther Ligand8I2G-FSH-Glycoprotein hormones alpha chain-Compound 716340-Gs/&β;1/&γ;2
17.65Consensusgs_pthOrthosteric Ligand8FLQ-PTH1-PTH-Gs/&β;1/&γ;2 7Y35-PTH1-Abaloparatide-Gs/&β;1/&γ;2 7Y36-PTH1-Teriparatide-Gs/&β;1/&γ;2 7F16-PTH2-TIP39-Gs/&β;1/&γ;2 7VVM-PTH1-PTH-Gs/&β;1/&γ;2 8FLU-PTH1-Long-acting PTH-Gs/&β;1/&γ;2 6NBF-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2
17.65Consensuslipid_offOrthosteric Ligandcannabinoid_off leuko_off lpl_off paf_off prostanoid_off
17.65Consensusp2y12_offOrthosteric Ligand4NTJ-P2Y12-AZD1283 7PP1-P2Y12-Selatogrel
17.65Consensuspaf_offOrthosteric Ligand5ZKQ-PAF-ABT-491 5ZKP-PAF-Foropafant (SR27417)
17.39Single7PIUSetmelanotide7PIU-MC4-Setmelanotide-Gs/&β;1/&γ;2
17.39Single7RKMFractalkine7RKM-US28-Fractalkine-Gi1/&β;1/&γ;2
17.39Single7VBINon-Acylated Tirzepatide7VBI-GLP-1-Non-Acylated Tirzepatide-Gs/&β;1/&γ;2
17.39Single7W0NElabela7W0N-Apelin-Elabela-Gi1/&β;1/&γ;2
17.39Single8F7QBeta-endorphin8F7Q-μ-Beta-endorphin-Gi1/&β;1/&γ;2
17.39Consensusvasopressin-ot_onOrthosteric Ligandot_on v2_on
17.24Single5VAIGLP-15VAI-GLP-1-GLP-1-Gs/&β;1/&γ;2
17.24Single7DUQGLP-17DUQ-GLP-1-GLP-1-PubChem 156022738-Gs/&β;1/&γ;2
17.24Consensusgs_crfOrthosteric Ligand6P9X-CRF1-Corticoliberin-Gs/&β;1/&γ;2
16.67Single3OE0CVX153OE0-CXCR4-CVX15
16.67Single4NTJAZD12834NTJ-P2Y12-AZD1283
16.67Single5ZBQUR-MK-2995ZBQ-Y1-UR-MK-299
16.67Single6GPXMK08126GPX-CCR2-MK0812
16.67Single6LW5WKYMVm6LW5-FPR2-ALX-WKYMVm
16.67Single6N4BMDMB-Fubinaca6N4B-CB1-MDMB-Fubinaca-Gi1/&β;1/&γ;2
16.67Single6RZ4Pranlukast6RZ4-CysLT1-Pranlukast-Na
16.67Single6RZ5Zafirlukast6RZ5-CysLT1-Zafirlukast-Na
16.67Single6W25SHU91196W25-MC4-SHU9119-Ca
16.67Single6WPWGlucagon derivative ZP37806WPW-Glucagon-Glucagon derivative ZP3780-Gs/&β;1/&γ;2
16.67Single7F4HAfamelanotide7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/&β;1/&γ;2
16.67Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
16.67Single7T9NPubChem 6440787T9N-TSH-M22 Fab-PubChem 644078-Gs/&β;1/&γ;2
16.67Single7XAUOctreotide7XAU-SST2-Octreotide-Gi1/&β;1/&γ;2
16.67Single7XOUCholecystokinin-87XOU-CCKA-Cholecystokinin-8-Gs/&β;1/&γ;2
16.67Single7Y26Octreotide7Y26-SST2-Octreotide-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
16.67Single7Y27Somatostatin-147Y27-SST2-Somatostatin-14-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
16.67Single7YXAONO-54306087YXA-S1P5-ONO-5430608
16.67Single8FLSAbaloparatide8FLS-PTH1-Abaloparatide-Gs/&β;1/&γ;2
16.67Single8FLULong-acting PTH8FLU-PTH1-Long-acting PTH-Gs/&β;1/&γ;2
16.67Single8GD9Rivenprost8GD9-EP4-Rivenprost-Gs/&β;1/&γ;2
16.67Single8XZGApelin-138XZG-Apelin-Apelin-13-Gi1/&β;1/&γ;2
16.67Single8XZHMM078XZH-Apelin-MM07-Gi1/&β;1/&γ;2
16.67Consensusglp_onOrthosteric Ligandglp1_on glp2_on
16.67Consensusgs_sstOrthosteric Ligand7Y27-SST2-Somatostatin-14-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
16.67Consensusmc5_onOrthosteric Ligand8INR-MC5-Alpha-MSH-Ca-chim(NtGi1-Gs)/&β;1/&γ;2 8IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
16.67Consensusmelanocortin_onOrthosteric Ligandmc2_on mc1_on mc3_on mc4_on mc5_on
16.67Consensusrxfp4_onOrthosteric Ligand7YK7-RXFP4-DC591053-Gi2/&β;1/&γ;2 7YJ4-RXFP4-INSL5-Gi2/&β;1/&γ;2 7YK6-RXFP4-PubChem 138319674-Gi2/&β;1/&γ;2
16.22Consensusgs_class-b1Orthosteric Ligandgs_glucagon gs_vip-pacap gs_pth gs_calcitonin gs_crf
16.13Single7VVMPTH7VVM-PTH1-PTH-Gs/&β;1/&γ;2
16.13Single8U1UCCL18U1U-CCR8-CCL1-Gi1/&β;1/&γ;2
16.00Single5WB2CX3CL1.355WB2-US28-CX3CL1.35
16.00Single6M1IPACAP6M1I-PAC1-PACAP-Gs/&β;1/&γ;2
16.00Single7AD3Alpha-factor mating pheromone7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
16.00Single7WUIIP157WUI-ADGRG2-IP15-chim(NtGi1-Gs)/&β;1/&γ;2
16.00Single7YONPeptide YY(3-36)7YON-Y2-Peptide YY(3-36)-Gi1/&β;1/&γ;2
16.00Single8HA0PTH8HA0-PTH1-PTH-chim(NtGi1-Gs)/&β;1/&γ;2
16.00Single8IA2C5a anaphylatoxin8IA2-C5a1-C5a anaphylatoxin-Go/&β;1/&γ;2
16.00Consensusbk2_onOrthosteric Ligand7F2O-BK2-Bradykinin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7F6I-BK2-Kallidin-Gq/&β;1/&γ;2
16.00Consensusclass-d_onOrthosteric Ligandste2_on
16.00Consensuscompl-peptide_onOrthosteric Ligandc5a1_on c3a_on
16.00Consensusgi_class-dOrthosteric Ligandgi_ste
16.00Consensusgi_steOrthosteric Ligand7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
16.00Consensusgo_class-bOrthosteric Ligandgo_class-b1 go_class-b2
15.79Single4OO9Mavoglurant4OO9-mGlu5-Mavoglurant
15.79Single5ZBHBMS-1938855ZBH-Y1-BMS-193885
15.79Single6O3CCholesterol6O3C-SMO-SAG21k-Cholesterol
15.79Single6W2XPubChem 237279706W2X-GABAB1, GABAB2-PubChem 5311042-PubChem 23727970
15.79Single7F58THIQ7F58-MC4-THIQ-Gs/&β;1/&γ;2
15.79Single7FEEPubMed 1048957FEE-CB1-PubMed 104895-ZCZ011
15.79Single7R0CAcyclovir triphosphate7R0C-V2-Acyclovir triphosphate-Arrestin2
15.79Single7XOWGastrin7XOW-CCKB-Gastrin-Gq/&β;1/&γ;2
15.79Single7XOXCholecystokinin-87XOX-CCKB-Cholecystokinin-8-Gq/&β;1/&γ;2
15.79Single8I2GCompound 7163408I2G-FSH-Glycoprotein hormones alpha chain-Compound 716340-Gs/&β;1/&γ;2
15.79Single8IUKPGF2-alpha8IUK-FP-alpha-PGF2-alpha-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
15.79Single8JD5BQI; HZE; PEF8JD5-mGlu2; mGlu4-Glutamate-BQI; HZE; PEF-Gi1/&β;1/&γ;2
15.79Single8X79MRE-2698X79-I2-MRE-269-Gs/&β;1/&γ;2
15.79Consensusrelaxin_onOrthosteric Ligandrxfp4_on
15.62Single7Y36Teriparatide7Y36-PTH1-Teriparatide-Gs/&β;1/&γ;2
15.62Single8FLQPTH8FLQ-PTH1-PTH-Gs/&β;1/&γ;2
15.62Consensusgs_vip-pacapOrthosteric Ligand8E3Y-VPAC1-PACAP27-Gs/&β;1/&γ;2 7VQX-VPAC1-PACAP27-Gs/&β;1/&γ;2 8E3Z-VPAC1-VIP-Gs/&β;1/&γ;2 6M1I-PAC1-PACAP-Gs/&β;1/&γ;2 6VN7-VPAC1-PACAP-Gs/&β;1/&γ;2
15.62Consensusmc2_onOrthosteric Ligand8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/&β;1/&γ;2; MRAP1
15.38Single2HPYAll-trans-retinal2HPY-Rhodopsin-All-trans-retinal
15.38Single6X18GLP-16X18-GLP-1-GLP-1-Gs/&β;1/&γ;2
15.38Single7F6IKallidin7F6I-BK2-Kallidin-Gq/&β;1/&γ;2
15.38Single7LLYOxyntomodulin7LLY-GLP-1-Oxyntomodulin-Gs/&β;1/&γ;2
15.38Single7P02Protachykinin-17P02-NK1-Protachykinin-1-chim(NtGi1-Gs)/&β;1/&γ;2
15.38Single7TRYUrocortin7TRY-CRF2-Urocortin-chim(NtGi1-G11)/&β;1/&γ;2
15.38Single7WBJPACAP277WBJ-VPAC1-PACAP27-Gs/&β;1/&γ;2
15.38Single8HCQEndothelin-18HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
15.38Single8HK5Complement C58HK5-C5a1-Complement C5-Gi1/&β;1/&γ;2
15.38Single8KH5Lysophosphatidylserine8KH5-GPR174-Lysophosphatidylserine-Gs/&β;1/&γ;2
15.38Consensuseta_onOrthosteric Ligand8HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
15.15Single6E3YCalcitonin gene-related peptide-16E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/&β;1/&γ;2; RAMP1
15.00Single4N4WSANT-14N4W-SMO-SANT-1
15.00Single6C1RPMX536C1R-C5a1-PMX53-Avacopan; Na
15.00Single6KPGAM8416KPG-CB1-AM841-Gi1/&β;1/&γ;2
15.00Single6KQIPubMed 1048956KQI-CB1-PubMed 104895-ORG27569
15.00Single6W2YPubChem 237279706W2Y-GABAB1; GABAB1-PubChem 5311042-PubChem 23727970
15.00Single7T6BS1P7T6B-S1P2-S1P-chim(NtGi1L-G13)/&β;1/&γ;2
15.00Single7W0NElabela7W0N-Apelin-Elabela-Gi1/&β;1/&γ;2
15.00Single7XW5ML1097XW5-TSH-TSH-ML109-Gs/&β;1/&γ;2
15.00Single7XW6ML1097XW6-TSH-M22 Fab-ML109-Gs/&β;1/&γ;2
15.00Single7Y66BM2137Y66-C5a1-BM213-Gi1/&β;1/&γ;2
15.00Single8GCPPGE28GCP-EP4-PGE2-Gi1/&β;1/&γ;2
15.00Single8H0QGastrin Releasing Peptide8H0Q-BB2-Gastrin Releasing Peptide-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
15.00Single8HK2C3a anaphylatoxin8HK2-C3aB-C3a anaphylatoxin-Gi1/&β;1/&γ;2
15.00Consensusadgrg_onOrthosteric Ligandadgrg2_on adgrg3_on
15.00Consensuscb1_off_alloOrthosteric Ligand6KQI-CB1-PubMed 104895-ORG27569
15.00Consensusclass-b2_onOrthosteric Ligandadgrg_on
15.00Consensusgi_prostanoidOrthosteric Ligand8GCP-EP4-PGE2-Gi1/&β;1/&γ;2 8GDC-EP3-PGE2-Gi1/&β;1/&γ;2 8GCM-EP4-L902688-Gi1/&β;1/&γ;2
15.00Consensusprostanoid_onOrthosteric Ligandep_on fpa_on
15.00Consensustsh_on_alloOther Ligand7XW5-TSH-TSH-ML109-Gs/&β;1/&γ;2
14.81Single4XT3Fractalkine4XT3-US28-Fractalkine
14.81Single6FJ3PTH6FJ3-PTH1-PTH
14.81Single6NBFLong-acting PTH analog6NBF-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2
14.81Single7CZ5Somatoliberin7CZ5-GHRH-Somatoliberin-Gs/&β;1/&γ;2
14.81Single7D3SSecretin7D3S-Secretin-Secretin-Gs/&β;1/&γ;2
14.81Single7FIYTirzepatide7FIY-GIP-Tirzepatide-Gs/&β;1/&γ;2
14.81Single7KI0Semaglutide7KI0-GLP-1-Semaglutide-Gs/&β;1/&γ;2
14.81Single7RA3GIP7RA3-GIP-GIP-chim(NtGi1-Gs)/&β;1/&γ;2
14.81Single7W57Neuromedin-S7W57-NMUR2-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
14.81Single7XV3Lysophosphatidylserine7XV3-GPR174-Lysophosphatidylserine-chim(NtGi1-Gs)/&β;1/&γ;2
14.81Single8JISPeptide-158JIS-GLP-1-Peptide-15-chim(NtGi1-Gs)/&β;1/&γ;2
14.81Consensusgi_neuromedinOrthosteric Ligand7XK8-NMUR2-Neuromedin-U-25-Gi1/&β;1/&γ;2
14.29Single2ZIY11-cis-Retinal2ZIY-Rhodopsin-11-cis-Retinal
14.29Single3OE6IT1t3OE6-CXCR4-IT1t
14.29Single3OE8IT1t3OE8-CXCR4-IT1t
14.29Single5TZYMK8666; PubChem 1270535975TZY-FFA1 (GPR40)-MK8666; PubChem 127053597
14.29Single6FK9PubChem 1324730366FK9-Rhodopsin-PubChem 132473036
14.29Single6LI0GTPL98046LI0-GPR52-GTPL9804
14.29Single6UVAAdrenomedullin-26UVA-CT Like (AM2)-Adrenomedullin-2-Gs/&β;1/&γ;2; RAMP3
14.29Single7DTYGIP7DTY-GIP-GIP-Gs/&β;1/&γ;2
14.29Single7P00Substance P7P00-NK1-Substance P-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
14.29Single7QVMOxytocin7QVM-OT-Oxytocin-chim(NtGi1-Go-CtGq)/&β;1/&γ;2
14.29Single7S1MEx4-D-Ala7S1M-GLP-1-Ex4-D-Ala-Gs/&β;1/&γ;2
14.29Single7VVJPTHrP(1-36)7VVJ-PTH1-PTHrP(1-36)-Gs/&β;1/&γ;2
14.29Single7XK8Neuromedin-U-257XK8-NMUR2-Neuromedin-U-25-Gi1/&β;1/&γ;2
14.29Single8FU6Glucagon derivative ZP37808FU6-Glucagon-Glucagon derivative ZP3780-Gs/&β;1/&γ;2
14.29Single8IQ6Latanoprost8IQ6-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
14.29Single8XJOU466198XJO-TP-U46619-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
14.29Consensusc5a1_off_ortoalloOrthosteric Ligand6C1Q-C5a1-PMX53-NDT9513727 6C1R-C5a1-PMX53-Avacopan; Na
14.29Consensusccr8_onOrthosteric Ligand8U1U-CCR8-CCL1-Gi1/&β;1/&γ;2
14.29Consensusep4_onOrthosteric Ligand7D7M-EP4-Dinoprostone-Gs/&β;1/&γ;1 8GCP-EP4-PGE2-Gi1/&β;1/&γ;2 8GD9-EP4-Rivenprost-Gs/&β;1/&γ;2 8GDA-EP4-L902688-Gs/&β;1/&γ;2
14.29Consensusgs_lipidOrthosteric Ligandgs_ffa gs_prostanoid
14.29Consensusgs_prostanoidOrthosteric Ligand8IUK-FP-alpha-PGF2-alpha-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7CX2-EP2-PGE2-Gs/&β;1/&γ;2 7CX3-EP2-Taprenepag-Gs/&β;1/&γ;2 7D7M-EP4-Dinoprostone-Gs/&β;1/&γ;1 7CX4-EP2-Evatanepag-Gs/&β;1/&γ;2 8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
14.29Consensusnk2_onOrthosteric Ligand7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
14.29Consensusste2_onOrthosteric Ligand7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
13.89Consensusclass-b1_onOrthosteric Ligandglucagon_on calcitonin_on vip-pacap_on pth_on crf_on
13.79Single6NBHLong-acting PTH analog6NBH-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2
13.79Single6PB1Urocortin6PB1-CRF2-Urocortin-chim(NtGi1-Gs)/&β;1/&γ;2
13.79Single6UUSAdrenomedullin6UUS-CT Like (AM2)-Adrenomedullin-Gs/&β;1/&γ;2; RAMP3
13.79Single8FLTM-PTH(1-14)8FLT-PTH1-M-PTH(1-14)-Gs/&β;1/&γ;2
13.79Single8HAFPTHrP(1-36)8HAF-PTH1-PTHrP(1-36)-chim(NtGi1-Gs)/&β;1/&γ;2
13.79Single8IY6Endothelin-18IY6-ETB-Endothelin-1
13.79Consensusgi_chemokineOrthosteric Ligand7VL9-CCR1-CCL15(26-92)-Gi1/&β;1/&γ;2 7XA3-CCR2-CCL2-Gi1/&β;1/&γ;2 7O7F-CCR5-(6P4)CCL5-Gi1/&β;1/&γ;1 7F1Q-CCR5-MIP-1a-Gi1/&β;1/&γ;2 7XBX-CX3CR1-CX3CL1-Gi1/&β;1/&γ;2 8IC0-CXCR1-Interleukin-8-Gi1/&β;1/&γ;2 6LFM-CXCR2-Interleukin-8-Gi1/&β;1/&γ;2 8U1U-CCR8-CCL1-Gi1/&β;1/&γ;2
13.64Single6C1QPMX536C1Q-C5a1-PMX53-NDT9513727
13.64Single7F9ZGHRP-67F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
13.64Single7NA7Ghrelin-277NA7-Ghrelin-Ghrelin-27-Gi1/&β;1/&γ;2
13.64Single7RMGSubstance P7RMG-NK1-Substance P-chim(Gs-CtGq)/&β;1/&γ;2
13.64Single7X8SWB4-247X8S-GLP-1-WB4-24-Gs/&β;1/&γ;2
13.64Single8IQ4Carboprost8IQ4-FP-alpha-Carboprost-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
13.64Single8JBFSenktide8JBF-NK3-Senktide-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
13.64Consensuschemokine_onOrthosteric Ligandcxcr_on cx3cr_on
13.64Consensusmc4_onOrthosteric Ligand7F53-MC4-Alpha-MSH-Gs/&β;1/&γ;2 7F55-MC4-Bremelanotide-Gs/&β;1/&γ;2 7PIV-MC4-Setmelanotide-Gs/&β;1/&γ;2 7F58-MC4-THIQ-Gs/&β;1/&γ;2 7F54-MC4-Afamelanotide-Gs/&β;1/&γ;2
13.64Consensusnk1_onOrthosteric Ligand8U26-NK1-Protachykinin-1-Gs/&β;1/&γ;2 7P00-NK1-Substance P-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
13.64Consensusprotein_onOrthosteric Ligandccr_on chemokine_on gphr_on chemerin_on
13.51Consensusgs_calcitoninOrthosteric Ligandgs_ct gs_cgrp
13.33Single6FK6PubChem 1324730336FK6-Rhodopsin-PubChem 132473033
13.33Single6PH7Nerol6PH7-Rhodopsin-Nerol-Gt(CT)
13.33Single7D76Beclomethasone7D76-ADGRG3-Beclomethasone-Go/&β;1/&γ;2
13.33Single7XP6Strychnine7XP6-T2R46-Strychnine-chim(Gs-CtGt3)/&β;1/&γ;2
13.33Single8H8JLodoxamide8H8J-GPR35-Lodoxamide-Ca-chim(NtGi1L-G13)/&β;1/&γ;2
13.33Single8IHIAcifran8IHI-HCA2-Acifran-Gi1/&β;1/&γ;2
13.33Single8JILNiacin8JIL-HCA2-Niacin-Gi1/&β;1/&γ;2
13.33Single8U4RREGN7663-Fab8U4R-CXCR4-REGN7663-Fab-Cholesterol
13.33Single8X2K5YM8X2K-GPR3-5YM-chim(NtGi1-Gs)/&β;1/&γ;2
13.33Consensusclass-t_onOrthosteric Ligandtaste2_on
13.33Consensusgo_adhesionOrthosteric Ligand7D77-ADGRG3-Hydrocortisone-Go/&β;1/&γ;2 7D76-ADGRG3-Beclomethasone-Go/&β;1/&γ;2
13.33Consensusgo_class-b2Orthosteric Ligandgo_adhesion
13.33Consensusgs_class-tOrthosteric Ligandgs_taste
13.33Consensusgs_tasteOrthosteric Ligand7XP6-T2R46-Strychnine-chim(Gs-CtGt3)/&β;1/&γ;2
13.33Consensustaste2_onOrthosteric Ligand7XP6-T2R46-Strychnine-chim(Gs-CtGt3)/&β;1/&γ;2
13.16Single8GY7Corticotropin8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/&β;1/&γ;2; MRAP1
13.04Single6X19CHU-1286X19-GLP-1-CHU-128-Gs/&β;1/&γ;2
13.04Single7F54Afamelanotide7F54-MC4-Afamelanotide-Gs/&β;1/&γ;2
13.04Single7RMHSubstance P7RMH-NK1-Substance P-Gs/&β;1/&γ;2
13.04Single7XMRSomatostatin-147XMR-SST2-Somatostatin-14-Gi1/&β;1/&γ;2
13.04Single8IZBLysophosphatidylserine8IZB-GPR174-Lysophosphatidylserine-Gs/&β;1/&γ;2
13.04Single8XBHS3E-LysoPS8XBH-GPR34-S3E-LysoPS-Gi1/&β;1/&γ;2
13.04Consensusnmur1_onOrthosteric Ligand7W56-NMUR1-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
13.04Consensusprotein_offOrthosteric Ligandccr_off chemokine_off gnrh_off
12.50Single3ODUIT1t3ODU-CXCR4-IT1t
12.50Single5U09Taranabant5U09-CB1-Taranabant
12.50Single5ZKQABT-4915ZKQ-PAF-ABT-491
12.50Single6FKBPubChem 1324730386FKB-Rhodopsin-PubChem 132473038
12.50Single6RNKNF-56-EJ406RNK-Succinate-NF-56-EJ40
12.50Single6WHCGlu16 analog of GCG6WHC-Glucagon-Glu16 analog of GCG-Gs/&β;1/&γ;2
12.50Single7BR3Elagolix7BR3-GnRH1-Elagolix
12.50Single7C6A(Sar1,Ile8)-Angiotensin II7C6A-AT2-(Sar1,Ile8)-Angiotensin II
12.50Single7E14Orforglipron7E14-GLP-1-Orforglipron-PubChem 156022738-Gs/&β;1/&γ;2
12.50Single7PIVSetmelanotide7PIV-MC4-Setmelanotide-Gs/&β;1/&γ;2
12.50Single7RMISubstance P7RMI-NK1-Substance P-chim(Gs-CtGq)/&β;1/&γ;2
12.50Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
12.50Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
12.50Single7SK5CXCL127SK5-ACKR3-CXCL12
12.50Single7V35Peptide-207V35-Glucagon-Peptide-20-Gs/&β;1/&γ;2
12.50Single7W56Neuromedin-S7W56-NMUR1-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
12.50Single7X2CFenoldopam7X2C-D1-Fenoldopam-Fenoldopam-Gs/&β;1/&γ;2
12.50Single7XBXCX3CL17XBX-CX3CR1-CX3CL1-Gi1/&β;1/&γ;2
12.50Single8HMPPubChem 699214798HMP-GPR52-PubChem 69921479-Gs/&β;1/&γ;2
12.50Single8JIPMEDI03828JIP-GLP-1-MEDI0382-chim(NtGi1-Gs)/&β;1/&γ;2
12.50Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
12.50Single8U4PAMD31008U4P-CXCR4-AMD3100-Cholesterol-Gi1/&β;1/&γ;2
12.50Single8U8FPML8U8F-GPR3-PML-Gs/&β;1/&γ;2
12.50Consensuscx3cr_onOrthosteric Ligandcx3cr1_on
12.50Consensusgnrh1_offOrthosteric Ligand7BR3-GnRH1-Elagolix
12.50Consensuspth1_onOrthosteric Ligand8FLQ-PTH1-PTH-Gs/&β;1/&γ;2 8FLR-PTH1-PTHrP(1-36)-Gs/&β;1/&γ;2 7Y36-PTH1-Teriparatide-Gs/&β;1/&γ;2 7Y35-PTH1-Abaloparatide-Gs/&β;1/&γ;2 8FLU-PTH1-Long-acting PTH-Gs/&β;1/&γ;2 6NBF-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2 7VVM-PTH1-PTH-Gs/&β;1/&γ;2
12.50Consensussst_offOrthosteric Ligandsst2_off
12.50Consensusvip-pacap_onOrthosteric Ligandvpac1_on vpac2_on pca1_on
12.12Consensusgs_glucagonOrthosteric Ligand6X18-GLP-1-GLP-1-Gs/&β;1/&γ;2 6B3J-GLP-1-Exendin-P5-Gs/&β;1/&γ;2 6WZG-Secretin-Secretin-Gs/&β;1/&γ;2 6X1A-GLP-1-Danuglipron-Gs/&β;1/&γ;2 7CZ5-GHRH-Somatoliberin-Gs/&β;1/&γ;2 7D68-GLP-2-GLP-2-Gs/&β;1/&γ;2 7DTY-GIP-GIP-Gs/&β;1/&γ;2 7FIM-GLP-1-Tirzepatide-Gs/&β;1/&γ;2 7FIN-GIP-Peptide-20; GGL-Gs/&β;1/&γ;2 7FIY-GIP-Tirzepatide-Gs/&β;1/&γ;2 7KI0-GLP-1-Semaglutide-Gs/&β;1/&γ;2 7RTB-GLP-1-Peptide-19-Gs/&β;1/&γ;2 7S1M-GLP-1-Ex4-D-Ala-Gs/&β;1/&γ;2 7VAB-GIP-Non-Acylated Tirzepatide-chim(NtGi1-Gs)/&β;1/&γ;2 8JIU-Glucagon-SAR425899-Gs/&β;1/&γ;2
12.12Consensuspth2_onOrthosteric Ligand7F16-PTH2-TIP39-Gs/&β;1/&γ;2
12.00Single7F4DAlpha-MSH7F4D-MC1-Alpha-MSH-chim(NtGi1-Gs)/&β;1/&γ;2
12.00Single7O7F(6P4)CCL57O7F-CCR5-(6P4)CCL5-Gi1/&β;1/&γ;1
12.00Single7VVNPTH7VVN-PTH1-PTH-Gs/&β;1/&γ;2
12.00Single7XA3CCL27XA3-CCR2-CCL2-Gi1/&β;1/&γ;2
12.00Single7XNACYN1548067XNA-SST2-CYN154806
12.00Consensusccr2_onOrthosteric Ligand7XA3-CCR2-CCL2-Gi1/&β;1/&γ;2
12.00Consensuscx3cr1_onOrthosteric Ligand7XBX-CX3CR1-CX3CL1-Gi1/&β;1/&γ;2
12.00Consensusgo_peptideOrthosteric Ligandgo_opioid go_ghrelin go_compl-peptide go_galanin go_vasopressin
12.00Consensusgs_tachykininOrthosteric Ligand8U26-NK1-Protachykinin-1-Gs/&β;1/&γ;2 7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7P00-NK1-Substance P-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
12.00Consensusmc3_onOrthosteric Ligand8IOC-MC3-Gamma-MSH-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
12.00Consensussst2_offOrthosteric Ligand7XNA-SST2-CYN154806
12.00Consensustachykinin_onOrthosteric Ligandnk1_on nk2_on
11.76Single6FFIMMPEP6FFI-mGlu5-MMPEP
11.76Single6FK8PubChem 1324730356FK8-Rhodopsin-PubChem 132473035
11.76Single6FKAPubChem 1324730376FKA-Rhodopsin-PubChem 132473037
11.76Single7S8PMS471347S8P-MRGPRX4-MS47134-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
11.76Single7VVOPTH7VVO-PTH1-PTH-Gs/&β;1/&γ;2
11.76Single7XOVSR1461317XOV-CCKA-SR146131-Gs/&β;1/&γ;2
11.76Single7XXH2MeSADP7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/&β;1/&γ;2
11.76Single8GCML9026888GCM-EP4-L902688-Gi1/&β;1/&γ;2
11.76Single8JIUSAR4258998JIU-Glucagon-SAR425899-Gs/&β;1/&γ;2
11.76Single8K4NVF08K4N-GPR34-VF0-Gi1/&β;1/&γ;2
11.76Single8WC8ZH86518WC8-TA1-ZH8651-chim(NtGi1-Gs)/&β;1/&γ;2
11.76Single8X7ATreprostinil8X7A-I2-Treprostinil-Gs/&β;1/&γ;2
11.76Consensusgnrh_offOrthosteric Ligandgnrh1_off
11.76Consensusgs_class-bOrthosteric Ligandgs_class-b1 gs_class-b2
11.54Single6MEOEnvelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd46MEO-CCR5-Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4
11.54Single6METEnvelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd46MET-CCR5-Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4
11.54Single7FINPeptide-20; GGL7FIN-GIP-Peptide-20; GGL-Gs/&β;1/&γ;2
11.54Single8XZJWN3538XZJ-Apelin-WN353-Gi1/&β;1/&γ;2
11.54Consensusnmur2_onOrthosteric Ligand7W57-NMUR2-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
11.54Consensusnmur_onOrthosteric Ligandnmur1_on nmur2_on
11.54Consensuspca1_onOrthosteric Ligand6M1I-PAC1-PACAP-Gs/&β;1/&γ;2
11.54Consensusste2_onOrthosteric Ligand7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
11.11Single6FFHFenobam6FFH-mGlu5-Fenobam
11.11Single6FK7PubChem 1324730346FK7-Rhodopsin-PubChem 132473034
11.11Single6FKCPubChem 1324730396FKC-Rhodopsin-PubChem 132473039
11.11Single6FKDPubChem 1373491836FKD-Rhodopsin-PubChem 137349183
11.11Single6IIVDaltroban6IIV-TP-Daltroban
11.11Single7F9YGhrelin-287F9Y-Ghrelin-Ghrelin-28-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
11.11Single7NA8PubChem 1780247NA8-Ghrelin-PubChem 178024-Gi1/&β;1/&γ;2
11.11Single7Y35Abaloparatide7Y35-PTH1-Abaloparatide-Gs/&β;1/&γ;2
11.11Single8EJCTAK-8758EJC-FFA1 (GPR40)-TAK-875-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
11.11Single8EJKTAK-8758EJK-FFA1 (GPR40)-TAK-875-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
11.11Single8XJLPGF2-alpha8XJL-FP-alpha-PGF2-alpha-chim(NtGi2-Gs-CtGq)/&β;1/&γ;2
11.11Consensusclass-c_offOther Ligandgabab_off mglu_off
11.11Consensuscrf2_onOrthosteric Ligand7TS0-CRF2-Urocortin-chim(NtGi1L-Go)/&β;1/&γ;2
11.11Consensusffa1_onOrthosteric Ligand8EIT-FFA1 (GPR40)-Doconexent-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2 8EJC-FFA1 (GPR40)-TAK-875-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2 8T3V-FFA1-DHA-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
11.11Consensusglucagon_onOrthosteric Ligandgip_on glu_on secretin_on ghrh_on glp_on
11.11Consensusgs_ghrelinOrthosteric Ligand7F9Y-Ghrelin-Ghrelin-28-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
11.11Consensusgs_melanocortinOrthosteric Ligand7F4D-MC1-Alpha-MSH-chim(NtGi1-Gs)/&β;1/&γ;2 7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/&β;1/&γ;2 7F54-MC4-Afamelanotide-Gs/&β;1/&γ;2 7F53-MC4-Alpha-MSH-Gs/&β;1/&γ;2 7F55-MC4-Bremelanotide-Gs/&β;1/&γ;2 7PIV-MC4-Setmelanotide-Gs/&β;1/&γ;2 7F4I-MC1-SHU9119-chim(NtGi1-Gs)/&β;1/&γ;2 7F58-MC4-THIQ-Gs/&β;1/&γ;2
11.11Consensusgs_neuromedinOrthosteric Ligand7W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7W56-NMUR1-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7W57-NMUR2-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
11.11Consensushcar_offOrthosteric Ligandsuccinate_off
11.11Consensusprostanoid_offOrthosteric Ligandep_off tp_off dp_off
11.11Consensussuccinate_offOrthosteric Ligand6RNK-Succinate-NF-56-EJ40 6Z10-Succinate-PubChem 154585554
11.11Consensustp_offOrthosteric Ligand6IIV-TP-Daltroban 6IIU-TP-Ramatroban
11.11Consensusvpac1_onOrthosteric Ligand8E3Y-VPAC1-PACAP27-Gs/&β;1/&γ;2 8E3Z-VPAC1-VIP-Gs/&β;1/&γ;2 6VN7-VPAC1-PACAP-Gs/&β;1/&γ;2
10.71Single5UIW5P7-CCL55UIW-CCR5-5P7-CCL5
10.71Single6NBILong-acting PTH analog6NBI-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2
10.71Single7SK4CXCL12_LRHQ7SK4-ACKR3-CXCL12_LRHQ
10.71Single7W3ZGastrin Releasing Peptide7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/&β;1/&γ;2
10.71Single8FLRPTHrP(1-36)8FLR-PTH1-PTHrP(1-36)-Gs/&β;1/&γ;2
10.71Single8HAOPTH8HAO-PTH1-PTH-chim(NtGi1-Gs)/&β;1/&γ;2
10.71Consensusccr5_offOrthosteric Ligand5UIW-CCR5-5P7-CCL5
10.71Consensusglp1_on_alloOrthosteric Ligand6VCB-GLP-1-GLP-1-LSN3160440-Gs/&β;1/&γ;2
10.53Single4PHUFasiglifam4PHU-FFA1 (GPR40)-Fasiglifam
10.53Single5T1APubChem 68764898; PubChem 120931705T1A-CCR2-PubChem 68764898; PubChem 12093170
10.53Single5YHLPubChem 1351213525YHL-EP4-PubChem 135121352
10.53Single5YWYONO-AE3-2085YWY-EP4-ONO-AE3-208
10.53Single6LFMInterleukin-86LFM-CXCR2-Interleukin-8-Gi1/&β;1/&γ;2
10.53Single6M9TMisoprostol-FA6M9T-EP3-Misoprostol-FA
10.53Single6XBKCholesterol6XBK-SMO-Cholesterol-Gi1/&β;1/&γ;2
10.53Single8GDAL9026888GDA-EP4-L902688-Gs/&β;1/&γ;2
10.53Single8GDCPGE28GDC-EP3-PGE2-Gi1/&β;1/&γ;2
10.53Single8IZ4Lysophosphatidylserine8IZ4-GPR34-Lysophosphatidylserine-Gi1/&β;1/&γ;2
10.53Consensusccr2_off_alloOther Ligand5T1A-CCR2-PubChem 68764898; PubChem 12093170 6GPX-CCR2-MK0812
10.53Consensusep3_onOrthosteric Ligand8GDC-EP3-PGE2-Gi1/&β;1/&γ;2
10.53Consensusep4_offOrthosteric Ligand5YWY-EP4-ONO-AE3-208 5YHL-EP4-PubChem 135121352
10.53Consensusep_offOrthosteric Ligandep4_off
10.34Consensusccr_onOrthosteric Ligandccr5_on ccr6_on ccr1_on ccr2_on ccr8_on
10.00Single5TZR-5TZR-FFA1 (GPR40)-MK8666
10.00Single7AUESetmelanotide7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/&β;1/&γ;2
10.00Single7F1TMIP-1a7F1T-CCR5-MIP-1a
10.00Single7P2L4YI7P2L-mGlu5-4YI
10.00Single7VVLPTH7VVL-PTH1-PTH-Gs/&β;1/&γ;2
10.00Single7XWONeurokinin-A7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
10.00Single7Y67C089 peptide7Y67-C5a1-C089 peptide-Gi1/&β;1/&γ;2
10.00Single8GDBPGE28GDB-EP4-PGE2-Gs/&β;1/&γ;2
10.00Single8HQCC5a anaphylatoxin8HQC-C5a1-C5a anaphylatoxin-Go/&β;1/&γ;2
10.00Single8T6JCDPPB8T6J-mGlu5; mGlu5-CDPPB
10.00Single8TAOCDPPB8TAO-mGlu5; mGlu5-Quisqualate-CDPPB
10.00Single8XBIS3E-LysoPS8XBI-GPR34-S3E-LysoPS
10.00Consensusmglu2_onOther Ligand7MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/&β;1/&γ;2 7E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/&β;1/&γ;2
10.00Consensuss1p2_onOrthosteric Ligand7T6B-S1P2-S1P-chim(NtGi1L-G13)/&β;1/&γ;2
10.00Consensussecretin_onOrthosteric Ligand6WZG-Secretin-Secretin-Gs/&β;1/&γ;2
9.68Single7RBTTirzepatide7RBT-GIP-Tirzepatide-PubChem 163183774-chim(NtGi1-Gs)/&β;1/&γ;2
9.52Single4PY02MeSATP4PY0-P2Y12-2MeSATP
9.52Single5X33BIIL2605X33-BLT1-BIIL260
9.52Single6AK3Dinoprostone IPGE26AK3-EP3-Dinoprostone IPGE2
9.52Single6IIURamatroban6IIU-TP-Ramatroban
9.52Single6OS2TRV0266OS2-AT1-TRV026
9.52Single6RZ7ONO-25703666RZ7-CysLT2-ONO-2570366
9.52Single6XOXOrforglipron6XOX-GLP-1-Orforglipron-chim(NtGi1-Gs)/&β;1/&γ;2
9.52Single7F55Bremelanotide7F55-MC4-Bremelanotide-Gs/&β;1/&γ;2
9.52Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/&β;1/&γ;2
9.52Single8T6JCDPPB8T6J-mGlu5; mGlu5-CDPPB
9.52Single8U26Protachykinin-18U26-NK1-Protachykinin-1-Gs/&β;1/&γ;2
9.52Single8WRBLysophosphatidylserine8WRB-GPR34-Lysophosphatidylserine-Gi1/&β;1/&γ;2
9.52Consensuschemokine_offOrthosteric Ligandcxcr_off
9.52Consensuscxcr4_offOrthosteric Ligand4RWS-CXCR4-vMIP-II
9.52Consensuscxcr_offOrthosteric Ligandcxcr4_off
9.52Consensusep_onOrthosteric Ligandep4_on ep2_on ep3_on
9.38Single7SK6CXCL12_LRHQ7SK6-ACKR3-CXCL12_LRHQ
9.38Single7VBHPeptide-207VBH-GLP-1-Peptide-20-Gs/&β;1/&γ;2
9.09Single4PXZ2MeSADP4PXZ-P2Y12-2MeSADP
9.09Single4RWSvMIP-II4RWS-CXCR4-vMIP-II
9.09Single6RZ9ONO-27703726RZ9-CysLT2-ONO-2770372
9.09Consensusadgrg2_onOrthosteric Ligand7XKD-ADGRG2-Betahydroxyandrosterone-Gs/&β;1/&γ;2 7WUI-ADGRG2-IP15-chim(NtGi1-Gs)/&β;1/&γ;2
9.09Consensuscyslt2_offOrthosteric Ligand6RZ6-CysLT2-ONO-2570366 6RZ9-CysLT2-ONO-2770372 6RZ8-CysLT2-ONO-2080365
9.09Consensuscyslt_offOrthosteric Ligandcyslt2_off
8.82Single8JITMEDI03828JIT-Glucagon-MEDI0382-Gs/&β;1/&γ;2
8.70Single6RZ6ONO-25703666RZ6-CysLT2-ONO-2570366
8.70Single7RKNFractalkine7RKN-US28-Fractalkine-Gi1/&β;1/&γ;2
8.70Single7S8LCortistatin-147S8L-MRGPRX2-Cortistatin-14-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
8.70Single7W2ZGhrelin7W2Z-Ghrelin-Ghrelin-Go/&β;1/&γ;2
8.70Single8INRAlpha-MSH8INR-MC5-Alpha-MSH-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
8.70Single8SAI1-oleoyl-2-hydroxy-sn-glycero-3-phospho-L-serine8SAI-GPR34-1-oleoyl-2-hydroxy-sn-glycero-3-phospho-L-serine-Gi1/&β;1/&γ;2
8.70Consensusgo_ghrelinOrthosteric Ligand7W2Z-Ghrelin-Ghrelin-Go/&β;1/&γ;2
8.70Consensusgs_adgrOrthosteric Ligand7XKD-ADGRG2-Betahydroxyandrosterone-Gs/&β;1/&γ;2 7WUI-ADGRG2-IP15-chim(NtGi1-Gs)/&β;1/&γ;2
8.70Consensusgs_class-b2Orthosteric Ligandgs_adgr
8.33Single5VBLApelin Mimetic Peptide Agonist5VBL-Apelin-Apelin Mimetic Peptide Agonist
8.33Single6RZ8ONO-20803656RZ8-CysLT2-ONO-2080365
8.33Single7W53Neuromedin-U-257W53-NMUR1-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
8.33Single8JIQPeptide-158JIQ-Glucagon-Peptide-15-Gs/&β;1/&γ;2
8.33Single8U4OCXCL128U4O-CXCR4-CXCL12-Cholesterol-Gi1/&β;1/&γ;2
8.00Single7F1QMIP-1a7F1Q-CCR5-MIP-1a-Gi1/&β;1/&γ;2
8.00Single7SHEPI; PE7SHE-GPR158-PI; PE
8.00Single8IBVMotilin8IBV-Motilin-Motilin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
8.00Single8IOCGamma-MSH8IOC-MC3-Gamma-MSH-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
7.89Consensusglu_onOrthosteric Ligand6LMK-Glucagon-Glucagon-Gs/&β;1/&γ;2 6WPW-Glucagon-Glucagon derivative ZP3780-Gs/&β;1/&γ;2 8JIT-Glucagon-MEDI0382-Gs/&β;1/&γ;2 8JIQ-Glucagon-Peptide-15-Gs/&β;1/&γ;2 7V35-Glucagon-Peptide-20-Gs/&β;1/&γ;2 8JIU-Glucagon-SAR425899-Gs/&β;1/&γ;2 6WHC-Glucagon-Glu16 analog of GCG-Gs/&β;1/&γ;2
7.69Single7V68PubChem 576644067V68-M4-Iperoxo-PubChem 57664406-Gi1/&β;1/&γ;2
7.69Single7XKEBetahydroxyandrosterone7XKE-ADGRG2-Betahydroxyandrosterone-chim(NtGi1-Gs)/&β;1/&γ;2
7.69Single8HQMNPGLY8HQM-GPR132-NPGLY-Gi1/&β;1/&γ;2
7.69Single8SZICa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZI-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi3/&β;1/&γ;2
7.69Consensusccr_offOrthosteric Ligandccr5_off ccr8_off
7.69Consensusclass-c_onOther Ligandgabab_on mglu_on
7.69Consensusgs_motilinOrthosteric Ligand8IBV-Motilin-Motilin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IBU-Motilin-Erythromycin A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
7.41Single5YQZGlucagon analogue5YQZ-Glucagon-Glucagon analogue
7.41Single6NIYAdrenomedullin6NIY-CT-Adrenomedullin-Gs/&β;1/&γ;2
7.41Consensusccr1_onOrthosteric Ligand7VL9-CCR1-CCL15(26-92)-Gi1/&β;1/&γ;2
7.41Consensusghrelin_onOrthosteric Ligand7W2Z-Ghrelin-Ghrelin-Go/&β;1/&γ;2 7F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7NA8-Ghrelin-PubChem 178024-Gi1/&β;1/&γ;2
7.14Single6OT025(S)-Epoxycholesterol6OT0-SMO-25(S)-Epoxycholesterol-Gi1/&β;1/&γ;2
7.14Single7VL9CCL15(26-92)7VL9-CCR1-CCL15(26-92)-Gi1/&β;1/&γ;2
7.14Single7XKDBetahydroxyandrosterone7XKD-ADGRG2-Betahydroxyandrosterone-Gs/&β;1/&γ;2
7.14Single8HVINOX-6-78HVI-GPR132-NOX-6-7-Gi1/&β;1/&γ;2
6.90Single7SK3CXCL127SK3-ACKR3-CXCL12
6.90Consensusccr5_onOrthosteric Ligand7O7F-CCR5-(6P4)CCL5-Gi1/&β;1/&γ;1 7F1Q-CCR5-MIP-1a-Gi1/&β;1/&γ;2
6.90Consensusctlike_onOrthosteric Ligand6E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/&β;1/&γ;2; RAMP1 6UUN-CT Like (AM1)-Adrenomedullin-Gs/&β;1/&γ;2; RAMP2
6.90Consensusghrh_onOrthosteric Ligand7CZ5-GHRH-Somatoliberin-Gs/&β;1/&γ;2
6.67Single5NX2GLP-1 (Truncated)5NX2-GLP-1-GLP-1 (Truncated)
6.67Single6LMKGlucagon6LMK-Glucagon-Glucagon-Gs/&β;1/&γ;2
6.67Single7D77Hydrocortisone7D77-ADGRG3-Hydrocortisone-Go/&β;1/&γ;2
6.67Single7V6APubChem 98642757V6A-M4-PubChem 9864275-Gi1/&β;1/&γ;2
6.67Single7VQXPACAP277VQX-VPAC1-PACAP27-Gs/&β;1/&γ;2
6.67Consensusgip_on_alloOther Ligand7RBT-GIP-Tirzepatide-PubChem 163183774-chim(NtGi1-Gs)/&β;1/&γ;2
6.67Consensusglp2_onOrthosteric Ligand7D68-GLP-2-GLP-2-Gs/&β;1/&γ;2
6.67Consensussmo_off_alloOrthosteric Ligand6D32-SMO-Cyclopamine-Cyclopamine
6.45Single7VVKPTH7VVK-PTH1-PTH-Gs/&β;1/&γ;2
6.45Consensuscalcitonin_onOrthosteric Ligandct_on ctlike_on
6.45Consensusglp1_onOrthosteric Ligand6X18-GLP-1-GLP-1-Gs/&β;1/&γ;2 6X19-GLP-1-CHU-128-Gs/&β;1/&γ;2 6X1A-GLP-1-Danuglipron-Gs/&β;1/&γ;2 7S1M-GLP-1-Ex4-D-Ala-Gs/&β;1/&γ;2 7LLL-GLP-1-Exendin-4-Gs/&β;1/&γ;2 6B3J-GLP-1-Exendin-P5-Gs/&β;1/&γ;2 8JIP-GLP-1-MEDI0382-chim(NtGi1-Gs)/&β;1/&γ;2 7VBI-GLP-1-Non-Acylated Tirzepatide-Gs/&β;1/&γ;2 6XOX-GLP-1-Orforglipron-chim(NtGi1-Gs)/&β;1/&γ;2 8JIS-GLP-1-Peptide-15-chim(NtGi1-Gs)/&β;1/&γ;2 7RTB-GLP-1-Peptide-19-Gs/&β;1/&γ;2 7VBH-GLP-1-Peptide-20-Gs/&β;1/&γ;2 7C2E-GLP-1-PubChem 149050799-Gs/&β;1/&γ;2 8JIR-GLP-1-SAR425899-chim(NtGi1-Gs)/&β;1/&γ;2 7KI0-GLP-1-Semaglutide-Gs/&β;1/&γ;2 7KI1-GLP-1-Taspoglutide-Gs/&β;1/&γ;2 7FIM-GLP-1-Tirzepatide-Gs/&β;1/&γ;2
6.45Consensusvpac2_onOrthosteric Ligand7VQX-VPAC1-PACAP27-Gs/&β;1/&γ;2
6.25Single4MQTLY21196204MQT-M2-Iperoxo-LY2119620
6.25Single5L7IVismodegib5L7I-SMO-Vismodegib
6.25Single6U1NLY21196206U1N-M2-LY2119620-Arrestin2
6.25Single7TRPLY20332987TRP-M4-Iperoxo-LY2033298-Gi1/&β;1/&γ;2
6.25Consensusgip_onOrthosteric Ligand7DTY-GIP-GIP-Gs/&β;1/&γ;2 7VAB-GIP-Non-Acylated Tirzepatide-chim(NtGi1-Gs)/&β;1/&γ;2 7FIN-GIP-Peptide-20; GGL-Gs/&β;1/&γ;2 7FIY-GIP-Tirzepatide-Gs/&β;1/&γ;2
6.25Consensusgip_on_alloOrthosteric Ligand7RBT-GIP-Tirzepatide-PubChem 163183774-chim(NtGi1-Gs)/&β;1/&γ;2
6.25Consensusm4_on_alloOther Ligand7TRP-M4-Iperoxo-LY2033298-Gi1/&β;1/&γ;2 7TRQ-M4-Iperoxo-VU0467154-Gi1/&β;1/&γ;2 7V68-M4-Iperoxo-PubChem 57664406-Gi1/&β;1/&γ;2
6.25Consensussmo_on_alloOrthosteric Ligand6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
5.88Single4XNVBPTU4XNV-P2Y1-BPTU
5.88Single6PWCNeurotensin6PWC-NTS1-Neurotensin-Arrestin2
5.88Single7F8YDevazepide7F8Y-CCKA-Devazepide
5.88Single7LCJDanuglipron7LCJ-GLP-1-Danuglipron
5.88Single7T94PubChem 576644067T94-M2-Acetylcholine-PubChem 57664406-chim(NtGi1-Go)/&β;1/&γ;2
5.88Single7VDLCortistatin-147VDL-MRGPRX2-Cortistatin-14-Gi1/&β;1/&γ;2
5.88Single7WV9ZCZ0117WV9-CB1-PubMed 104895-ZCZ011-Gi2/&β;1/&γ;2
5.88Single8JIRSAR4258998JIR-GLP-1-SAR425899-chim(NtGi1-Gs)/&β;1/&γ;2
5.88Consensuscb1_on_alloOther Ligand7WV9-CB1-PubMed 104895-ZCZ011-Gi2/&β;1/&γ;2
5.88Consensuscxcr1_onOrthosteric Ligand8IC0-CXCR1-Interleukin-8-Gi1/&β;1/&γ;2
5.88Consensusm2_on_alloOther Ligand7T94-M2-Acetylcholine-PubChem 57664406-chim(NtGi1-Go)/&β;1/&γ;2 6OIK-M2-Iperoxo-LY2119620-chim(NtGi1-Go)/&β;1/&γ;2
5.88Consensusp2y_offOrthosteric Ligandp2y1_off p2y12_off
5.88Consensussmo_on_alloOther Ligand6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
5.56Single6WJCMuscarinic toxin 76WJC-M1-Atropine-Muscarinic toxin 7
5.56Single6ZA8RTI-3a6ZA8-NTS1-RTI-3a
5.56Single7C2EPubChem 1490507997C2E-GLP-1-PubChem 149050799-Gs/&β;1/&γ;2
5.56Single7TRQVU04671547TRQ-M4-Iperoxo-VU0467154-Gi1/&β;1/&γ;2
5.56Single7UTZPubChem 6440787UTZ-TSH-TR1402-PubChem 644078-Gs/&β;1/&γ;2
5.56Single8IYXYL-3658IYX-GPR34-YL-365
5.56Single8JD6N-(3-chlorophenyl)pyridine-2-carboxamide8JD6-mGlu4; mGlu4-Phosphoserine-N-(3-chlorophenyl)pyridine-2-carboxamide-Gi3/&β;1/&γ;2
5.56Single8K2WAMG4878K2W-CXCR3-AMG487
5.56Single8T3VDHA8T3V-FFA1-DHA-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
5.56Consensuscxcr2_onOrthosteric Ligand6LFM-CXCR2-Interleukin-8-Gi1/&β;1/&γ;2
5.56Consensuscxcr_onOrthosteric Ligandcxcr1_on cxcr2_on
5.56Consensuslh_on_alloOther Ligand7FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/&β;1/&γ;2
5.56Consensusm1_off_alloOther Ligand6WJC-M1-Atropine-Muscarinic toxin 7
5.26Single4QIMPubChem 249053754QIM-SMO-PubChem 24905375
5.26Single6X1ADanuglipron6X1A-GLP-1-Danuglipron-Gs/&β;1/&γ;2
5.26Single7FIHOrg435537FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/&β;1/&γ;2
5.26Single7LCIDanuglipron7LCI-GLP-1-Danuglipron-Gs/&β;1/&γ;2
5.26Single7LCKDanuglipron7LCK-GLP-1-Danuglipron
5.26Single8IC0Interleukin-88IC0-CXCR1-Interleukin-8-Gi1/&β;1/&γ;2
5.26Consensussmo_offOrthosteric Ligand5L7I-SMO-Vismodegib 4O9R-SMO-Cyclopamine 4QIM-SMO-PubChem 24905375 4JKV-SMO-Taladegib (LY2940680)
5.00Single4JKVTaladegib (LY2940680)4JKV-SMO-Taladegib (LY2940680)
5.00Single7VV0PAMP-127VV0-MRGPRX2-PAMP-12
5.00Single7VV4Cortistatin-147VV4-MRGPRX2-Cortistatin-14
5.00Single8FN1Neurotensin/neuromedin N8FN1-NTS1-Neurotensin/neuromedin N-chim(NtGi1-Go)/&β;1/&γ;2
5.00Single8JPCNeurotensin 8-138JPC-NTS1-Neurotensin 8-13-PubChem 118610427; GDP; Mg-Gq; GRK2
5.00Single8SZICa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZI-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi3/&β;1/&γ;2
4.76Single5V56TC1145V56-SMO-TC114
4.76Single5V57TC1145V57-SMO-TC114
4.76Single6OS1TRV0266OS1-AT1-TRV026
4.76Single6Z4QSR142948A6Z4Q-NTS1-SR142948A
4.76Single7S8MCortistatin-147S8M-MRGPRX2-Cortistatin-14-Gi1/&β;1/&γ;2
4.76Single7XBDGalanin7XBD-GAL2-Galanin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
4.76Single7XJLSpexin7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
4.76Single8JD5BQI; HZE; PEF8JD5-mGlu2; mGlu4-Glutamate-BQI; HZE; PEF-Gi1/&β;1/&γ;2
4.55Single3VW7Vorapaxar; Na3VW7-PAR1-Vorapaxar; Na
4.55Single4XEENeurotensin4XEE-NTS1-Neurotensin
4.55Single4XESNeurotensin4XES-NTS1-Neurotensin
4.55Single6YVRNTS8-136YVR-NTS1-NTS8-13
4.55Single7D7MDinoprostone7D7M-EP4-Dinoprostone-Gs/&β;1/&γ;1
4.55Single7L0SNeurotensin7L0S-NTS1-Neurotensin-Gi1/&β;1/γ1
4.55Single7SHEPI; PE7SHE-GPR158-PI; PE
4.55Single7XXI2MeSADP7XXI-P2Y12-2MeSADP-Gi2/&β;1/&γ;2
4.55Single8IBUErythromycin A8IBU-Motilin-Erythromycin A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
4.55Consensusgalanin_onOrthosteric Ligandgal2_on gal1_on
4.55Consensusnts1_offOrthosteric Ligand6Z4Q-NTS1-SR142948A 6Z4S-NTS1-SR48692
4.55Consensusnts_offOrthosteric Ligandnts1_off
4.35Single4BUONeurotensin4BUO-NTS1-Neurotensin
4.35Single6M1HMaxadilan6M1H-PAC1-Maxadilan-Gs/&β;1/&γ;2
4.35Single7CX2PGE27CX2-EP2-PGE2-Gs/&β;1/&γ;2
4.35Single7CX4Evatanepag7CX4-EP2-Evatanepag-Gs/&β;1/&γ;2
4.35Single7SHFPI; PE7SHF-GPR158-PI; PE-B5; RGS7
4.35Consensusep2_onOrthosteric Ligand7CX4-EP2-Evatanepag-Gs/&β;1/&γ;2 7CX2-EP2-PGE2-Gs/&β;1/&γ;2 7CX3-EP2-Taprenepag-Gs/&β;1/&γ;2
4.35Consensusgal2_onOrthosteric Ligand7WQ4-GAL2-Galanin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
4.35Consensusgs_galaninOrthosteric Ligand7WQ4-GAL2-Galanin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
4.17Single6KNMJN241-96KNM-Apelin-JN241-9
4.17Consensusmotilin_onOrthosteric Ligand8IBV-Motilin-Motilin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IBU-Motilin-Erythromycin A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
4.00Single7CX3Taprenepag7CX3-EP2-Taprenepag-Gs/&β;1/&γ;2
4.00Single7L0RNeurotensin7L0R-NTS1-Neurotensin-Gi1/&β;1/&γ;1
4.00Single7RTBPeptide-197RTB-GLP-1-Peptide-19-Gs/&β;1/&γ;2
3.85Single7SHFPI; PE7SHF-GPR158-PI; PE-B5; RGS7
3.70Single7W55Neuromedin-U-257W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
3.12Single7TYWCalcitonin-17TYW-CT (AMY1)-Calcitonin-1-Gs/&β;1/&γ;2; RAMP1
3.03Single7TYFAmylin7TYF-CT (AMY1)-Amylin-Gs/&β;1/&γ;2; RAMP1
3.03Single7TYIAmylin7TYI-CT-Amylin-Gs/&β;1/&γ;2
3.03Single7TYNCalcitonin-17TYN-CT-Calcitonin-1-Gs/&β;1/&γ;2
2.94Single7TYHCalcitonin-17TYH-CT (AMY2)-Calcitonin-1-Gs/&β;1/&γ;2; RAMP2
2.86Single7TZFAmylin7TZF-CT (AMY3)-Amylin-Gs/&β;1/&γ;2; RAMP3
2.86Single8F0KPramlintide analogue san3858F0K-CT (AMY3)-Pramlintide analogue san385-Gs/&β;1/&γ;2; RAMP3
2.78Single7TYYCalcitonin-17TYY-CT (AMY2)-Calcitonin-1-Gs/&β;1/&γ;2; RAMP2
2.78Single9AUCCalcitonin gene-related peptide-19AUC-CT-Calcitonin gene-related peptide-1-Gs/&β;1/&γ;2; RAMP1
2.63Single8F2APramlintide analogue san3858F2A-CT (AMY3)-Pramlintide analogue san385-Gs/&β;1/&γ;2; RAMP3
2.63Consensusct_onOrthosteric Ligand7TYL-CT-Amylin-Gs/&β;1/&γ;2 7TYN-CT-Calcitonin-1-Gs/&β;1/&γ;2 8F0J-CT-Pramlintide analogue san45-Gs/&β;1/&γ;2 6NIY-CT-Adrenomedullin-Gs/&β;1/&γ;2
2.50Single7TYOCalcitonin7TYO-CT-Calcitonin-Gs/&β;1/&γ;2
2.44Single8F2BPramlintide analogue san458F2B-CT (AMY3)-Pramlintide analogue san45-Gs/&β;1/&γ;2; RAMP3
2.44Consensusgs_ctOrthosteric Ligand7TYN-CT-Calcitonin-1-Gs/&β;1/&γ;2 6NIY-CT-Adrenomedullin-Gs/&β;1/&γ;2 8F0J-CT-Pramlintide analogue san45-Gs/&β;1/&γ;2 7TYL-CT-Amylin-Gs/&β;1/&γ;2 8F0K-CT (AMY3)-Pramlintide analogue san385-Gs/&β;1/&γ;2; RAMP3
2.33Single8F0JPramlintide analogue san458F0J-CT-Pramlintide analogue san45-Gs/&β;1/&γ;2

2D representation of the interactions of this orthosteric/allosteric ligand.


Links and nodes colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:I121 R:R:P211 10.16 0 No No 7 8 2 1
R:R:E122 R:R:V157 5.7 0 No No 5 7 1 2
R:R:E122 R:R:S161 4.31 0 No No 5 8 1 2
R:R:E122 W:W:?4 17.18 0 No Yes 5 0 1 0
R:R:C125 W:W:?4 11.22 0 No Yes 7 0 1 0
R:R:V129 R:R:V218 6.41 0 No No 6 6 1 2
R:R:V129 W:W:?4 10.54 0 No Yes 6 0 1 0
R:R:V210 W:W:?4 19.32 0 No Yes 5 0 1 0
R:R:P211 W:W:?4 13.55 0 No Yes 8 0 1 0
R:R:I214 W:W:?4 5.05 0 No Yes 6 0 1 0
R:R:V206 W:W:?4 1.76 0 No Yes 4 0 1 0

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

ShowSimilarityNetwork TypeNameLigandDescription
100.00Consensusbeta2_off_alloOther Ligand6OBA-β2-(S)-Alprenolol-GTPL11074
63.64Single6C1RAvacopan; Na6C1R-C5a1-PMX53-Avacopan; Na
63.64Consensusc5a1_off_ortoalloOther Ligand6C1Q-C5a1-PMX53-NDT9513727 6C1R-C5a1-PMX53-Avacopan; Na
60.00Single6C1QNDT95137276C1Q-C5a1-PMX53-NDT9513727
54.55Single5O9HNDT95137275O9H-C5a1-NDT9513727
37.50Single5TZYMK8666; PubChem 1270535975TZY-FFA1 (GPR40)-MK8666; PubChem 127053597
36.36Single7CKZMevidalen7CKZ-D1-Dopamine-Mevidalen-Gs/&β;1/&γ;2
31.25Single7SHEPI; PE7SHE-GPR158-PI; PE
25.00Single5KW2PubChem 1330539535KW2-FFA1 (GPR40)-PubChem 133053953
25.00Single7SHEPI; PE7SHE-GPR158-PI; PE
25.00Single7SHFPI; PE7SHF-GPR158-PI; PE-B5; RGS7
23.08Single8U8FPML8U8F-GPR3-PML-Gs/&β;1/&γ;2
22.22Single7SHFPI; PE7SHF-GPR158-PI; PE-B5; RGS7
20.00Single5XSZGlyceryl Mono-oleate5XSZ-LPA6-Glyceryl Mono-oleate
15.38Single8X2K5YM8X2K-GPR3-5YM-chim(NtGi1-Gs)/&β;1/&γ;2
11.11Single8JLPRalmitaront8JLP-TA1-Ralmitaront-Gs/&β;1/&γ;2
11.11Consensuss1p2_onOrthosteric Ligand7T6B-S1P2-S1P-chim(NtGi1L-G13)/&β;1/&γ;2
10.53Single7T6BS1P7T6B-S1P2-S1P-chim(NtGi1L-G13)/&β;1/&γ;2
10.53Single8WRBLysophosphatidylserine8WRB-GPR34-Lysophosphatidylserine-Gi1/&β;1/&γ;2
9.09Single6RZ8ONO-20803656RZ8-CysLT2-ONO-2080365
7.41Single7XV3Lysophosphatidylserine7XV3-GPR174-Lysophosphatidylserine-chim(NtGi1-Gs)/&β;1/&γ;2
7.14Single7YFCHistamine7YFC-H4-Histamine-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
7.14Single7YFDImetit7YFD-H4-Imetit-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
7.14Single8HN8Histamine8HN8-H4-Histamine-Gi1/&β;1/&γ;2
7.14Single8J6QCompound 9n8J6Q-HCA2-Beta-hydroxybutyrate-Compound 9n-Gi1/&β;1/&γ;2
7.14Single8JIICompound 9n8JII-HCA2-Niacin-Compound 9n-Gi1/&β;1/&γ;2
7.14Consensushca2_on_alloOther Ligand8J6P-HCA2-Niacin-Compound 9n-Gi1/&β;1/&γ;2 8J6Q-HCA2-Beta-hydroxybutyrate-Compound 9n-Gi1/&β;1/&γ;2
6.67Single8G2YLPC8G2Y-ADGRF1-LPC-chim(Gs-CtGq)/&β;1/&γ;2
6.67Single8HOCImetit8HOC-H4-Imetit-Gi1/&β;1/&γ;2
6.67Single8J6PCompound 9n8J6P-HCA2-Niacin-Compound 9n-Gi1/&β;1/&γ;2
6.67Single8JHYCompound 9n8JHY-HCA2-Compound 9n-Gi1/&β;1/&γ;2
6.67Consensusd1_on_alloOther Ligand7LJC-D1-PubChem 86764103-Mevidalen-Gs/&β;1/&γ;2 7CKZ-D1-Dopamine-Mevidalen-Gs/&β;1/&γ;2
6.67Consensusgi_histamineOrthosteric Ligand8HN8-H4-Histamine-Gi1/&β;1/&γ;2 8HOC-H4-Imetit-Gi1/&β;1/&γ;2
6.67Consensusgs_histamineOrthosteric Ligand7YFC-H4-Histamine-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7YFD-H4-Imetit-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
6.67Consensush4_onOrthosteric Ligand7YFC-H4-Histamine-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7YFD-H4-Imetit-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
6.25Single6N48PubChem 1384542566N48-β2-BI167107-PubChem 138454256
6.25Single8IYXYL-3658IYX-GPR34-YL-365
5.88Consensushistamine_onOrthosteric Ligandh1_on h4_on
5.56Single7EW3S1P7EW3-S1P3-S1P-Gi1/&β;1/&γ;2
5.56Single7WU5K6G7WU5-ADGRF1-K6G-Gi1/&β;1/&γ;2
5.56Single8IZ4Lysophosphatidylserine8IZ4-GPR34-Lysophosphatidylserine-Gi1/&β;1/&γ;2
5.26Single7EW4CYM55417EW4-S1P3-CYM5541-Gi1/&β;1/&γ;2
5.26Single7WU4K6G7WU4-ADGRF1-K6G-Gi1/&β;1/&γ;2
5.26Single8JXVClozapine8JXV-H4-Clozapine-Gi1/&β;1/&γ;2
5.26Single8JXWVUF68848JXW-H4-VUF6884-Gi1/&β;1/&γ;2
5.26Single8JXXClobenpropit8JXX-H4-Clobenpropit-Gi1/&β;1/&γ;2
5.26Consensusmglu2_onOther Ligand7MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/&β;1/&γ;2 7E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/&β;1/&γ;2
5.00Single6RZ7ONO-25703666RZ7-CysLT2-ONO-2570366
5.00Single7EO4BAF3127EO4-S1P1-BAF312-Gi1/&β;1/&γ;2
5.00Single7EVYSiponimod7EVY-S1P1-Siponimod-Gi1/&β;1/&γ;2
5.00Single7XZ5Lysophosphatidylcholine7XZ5-GPR119-Lysophosphatidylcholine-Gs/&β;1/&γ;2
4.76Single6RZ9ONO-27703726RZ9-CysLT2-ONO-2770372
4.76Single7EVZCenerimod7EVZ-S1P1-Cenerimod-Gi1/&β;1/&γ;2
4.76Single7EW0Ozanimod7EW0-S1P1-Ozanimod-Gi1/&β;1/&γ;2
4.76Consensuscyslt2_offOrthosteric Ligand6RZ6-CysLT2-ONO-2570366 6RZ9-CysLT2-ONO-2770372 6RZ8-CysLT2-ONO-2080365
4.76Consensuscyslt_offOrthosteric Ligandcyslt2_off
4.55Single6RZ6ONO-25703666RZ6-CysLT2-ONO-2570366
4.55Single8SAI1-oleoyl-2-hydroxy-sn-glycero-3-phospho-L-serine8SAI-GPR34-1-oleoyl-2-hydroxy-sn-glycero-3-phospho-L-serine-Gi1/&β;1/&γ;2
4.35Single7TD4Siponimod7TD4-S1P1-Siponimod-Gi1/&β;1/&γ;2
4.35Single8IZBLysophosphatidylserine8IZB-GPR174-Lysophosphatidylserine-Gs/&β;1/&γ;2
3.85Single7W40Bombesin7W40-BB2-Bombesin-chim(NtGi1L-Gq)/&β;1/&γ;2
3.70Consensuscrf2_onOrthosteric Ligand7TS0-CRF2-Urocortin-chim(NtGi1L-Go)/&β;1/&γ;2
3.57Consensusglp1_on_alloOrthosteric Ligand6VCB-GLP-1-GLP-1-LSN3160440-Gs/&β;1/&γ;2
3.33Consensussecretin_onOrthosteric Ligand6WZG-Secretin-Secretin-Gs/&β;1/&γ;2
3.23Consensusgip_on_alloOrthosteric Ligand7RBT-GIP-Tirzepatide-PubChem 163183774-chim(NtGi1-Gs)/&β;1/&γ;2
3.03Consensuspth1_onOrthosteric Ligand8FLQ-PTH1-PTH-Gs/&β;1/&γ;2 8FLR-PTH1-PTHrP(1-36)-Gs/&β;1/&γ;2 7Y36-PTH1-Teriparatide-Gs/&β;1/&γ;2 7Y35-PTH1-Abaloparatide-Gs/&β;1/&γ;2 8FLU-PTH1-Long-acting PTH-Gs/&β;1/&γ;2 6NBF-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2 7VVM-PTH1-PTH-Gs/&β;1/&γ;2

PDB Summary
PDB 6OBA
Class A
SubFamily Amine
Type Adrenergic
SubType Beta2
Species Homo sapiens
Ligand (S)-Alprenolol
Other Ligand(s) GTPL11074
Protein Partners -
PDB Resolution 3.1
Date 2020-03-25
D.O.I. 10.1038/s41589-020-0549-2
Net Summary
Imin 4.09
Number of Linked Nodes 260
Number of Links 286
Number of Hubs 37
Number of Links mediated by Hubs 137
Number of Communities 7
Number of Nodes involved in Communities 40
Number of Links involved in Communities 51
Path Summary
Number Of Nodes in MetaPath 60
Number Of Links MetaPath 59
Number of Shortest Paths 76502
Length Of Smallest Path 3
Average Path Length 13.992
Length of Longest Path 28
Minimum Path Strength 1.43
Average Path Strength 8.15568
Maximum Path Strength 26.255
Minimum Path Correlation 0.7
Average Path Correlation 0.91856
Maximum Path Correlation 0.99
Minimum % Of Corr. Nodes 4.34783
Average % Of Corr. Nodes 43.0226
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 50.0054
Maximum Path Hubs % 100
AnnotationTypeLinks
Gene OntologyMolecular Function
Gene OntologyBiological Process
Gene OntologyCellular Component
SCOP2Domain Identifier
SCOP2Family Identifier
Membrane Protein Annotations-• Orientations of Proteins in Membranes database (OPM)   • Protein Data Bank of Transmembrane Proteins (PDBTM)   • MemProtMD


Details about the values in these tables can be found in the corresponding documentation page .
CodeJTZ
PDB ResiduesL:L:?3
Environment DetailsOpen EMBL-EBI Page
CodeJTZ
Name(2S)-1-[(1-methylethyl)amino]-3-(2-prop-2-en-1-ylphenoxy)propan-2-ol
Synonyms
Identifier(2S)-1-(propan-2-ylamino)-3-(2-prop-2-enylphenoxy)propan-2-ol
FormulaC15 H23 N O2
Molecular Weight249.349
SMILESCC(C)NC[C@@H](COc1ccccc1CC=C)O
PubChem204665
Formal Charge0
Total Atoms41
Total Chiral Atoms1
Total Bonds41
Total Aromatic Bonds6

CodeM3J
PDB ResiduesW:W:?4
Environment DetailsOpen EMBL-EBI Page
CodeM3J
Name6-bromo-N~2~-phenylquinazoline-2,4-diamine
Synonyms
Identifier6-bromanyl-~{N}2-phenyl-quinazoline-2,4-diamine
FormulaC14 H11 Br N4
Molecular Weight315.168
SMILESc1ccc(cc1)Nc2nc3ccc(cc3c(n2)N)Br
PubChem145998261
Formal Charge0
Total Atoms30
Total Chiral Atoms0
Total Bonds32
Total Aromatic Bonds17

PDBsumOpen PDBsum Page
ChainR
ProteinReceptor
UniProtP07550
Sequence
>6OBA_Chain_R
VWVVGMGIV MSLIVLAIV FGNVLVITA IAKFERLQT VTNYFITSL 
ACADLVMGL AVVPFGAAH ILMKMWTFG NFWCEFWTS IDVLCVTAS 
IETLCVIAV DRYFAITSP FKYQSLLTK NKARVIILM VWIVSGLTS 
FLPIQMHWY RATHQEAIN CYAEETCCD FFTNQAYAI ASSIVSFYV 
PLVIMVFVY SRVFQEAKR QLKFCLKEH KALKTLGII MGTFTLCWL 
PFFIVNIVH VIQDNLIRK EVYILLNWI GYVNSGFNP LIYCRSPDF 
RIAFQELLC L


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  



This network is also present in following consensuses:
IdComponents
beta2_off_allo6OBA-β2-(S)-Alprenolol-GTPL11074

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
2R4RAAmineAdrenergicβ2Homo sapiens---3.42007-11-0610.1038/nature06325
2R4SAAmineAdrenergicβ2Homo sapiens---3.42007-11-0610.1038/nature06325
2RH1AAmineAdrenergicβ2Homo sapiens(S)-Carazolol--2.42007-10-3010.1126/science.1150577
3D4SAAmineAdrenergicβ2Homo sapiensTimolol Maleate--2.82008-06-1710.1016/j.str.2008.05.001
3KJ6AAmineAdrenergicβ2Homo sapiens---3.42010-02-1610.1038/nature08650
3NY8AAmineAdrenergicβ2Homo sapiensICI 118-551--2.842010-08-1110.1021/ja105108q
3NY9AAmineAdrenergicβ2Homo sapiensPubChem 913103--2.842010-08-1110.1021/ja105108q
3NYAAAmineAdrenergicβ2Homo sapiens(S)-Alprenolol--3.162010-08-1110.1021/ja105108q
3P0GAAmineAdrenergicβ2Homo sapiensBI167107--3.52011-01-1910.1038/nature09648
3PDSAAmineAdrenergicβ2Homo sapiensHydroxybenzylisoproterenol--3.52011-01-1210.1038/nature09665
3SN6AAmineAdrenergicβ2Homo sapiensBI167107-Gs/&β;1/&γ;23.22011-07-2010.1038/nature10361
4GBRAAmineAdrenergicβ2Homo sapiens(S)-Carazolol--3.992012-10-2410.1371/journal.pone.0046039
4LDEAAmineAdrenergicβ2Homo sapiensBI167107--2.792013-09-2510.1038/nature12572
4LDLAAmineAdrenergicβ2Homo sapiensHydroxybenzylisoproterenol--3.12013-09-2510.1038/nature12572
4LDOAAmineAdrenergicβ2Homo sapiensL-Epinephrine--3.22013-09-2510.1038/nature12572
4QKXAAmineAdrenergicβ2Homo sapiensPubChem 76210628--3.32014-07-2310.1073/pnas.1410415111
5D5AAAmineAdrenergicβ2Homo sapiens(S)-Carazolol--2.482016-01-1310.1107/S2059798315021683
5D5BAAmineAdrenergicβ2Homo sapiens(S)-Carazolol--3.82016-01-1310.1107/S2059798315021683
5D6LAAmineAdrenergicβ2Homo sapiens(S)-Carazolol--3.22016-08-1710.1038/nprot.2017.057
5JQHAAmineAdrenergicβ2Homo sapiens(S)-Carazolol--3.22016-07-1310.1038/nature18636
5X7DAAmineAdrenergicβ2Homo sapiens(S)-CarazololPubChem 129318963-2.72017-08-1610.1038/nature23652
6E67AAmineAdrenergicβ2Homo sapiensBI167107-Gs (fused)3.72019-06-0510.1016/j.cell.2019.04.021
6MXTAAmineAdrenergicβ2Homo sapiensSalmeterol--2.962018-11-1410.1038/s41589-018-0145-x
6N48AAmineAdrenergicβ2Homo sapiensBI167107PubChem 138454256-3.22019-06-2610.1126/science.aaw8981
6NI3AAmineAdrenergicβ2Homo sapiensBI167107-Gs/&β;1/&γ;23.82019-11-2010.1038/s41594-019-0330-y
6PRZAAmineAdrenergicβ2Homo sapiens(S)-Alprenolol--2.82019-11-1310.1107/S2052252519013137
6PS0AAmineAdrenergicβ2Homo sapiens(S)-Carazolol--3.42019-11-1310.1107/S2052252519013137
6PS1AAmineAdrenergicβ2Homo sapiensTimolol--3.22019-11-1310.1107/S2052252519013137
6PS2AAmineAdrenergicβ2Homo sapiens(S)-Alprenolol--2.42019-11-1310.1107/S2052252519013137
6PS3AAmineAdrenergicβ2Homo sapiens(S)-Carvedilol--2.52019-11-1310.1107/S2052252519013137
6PS4AAmineAdrenergicβ2Homo sapiensICI 118-551--2.62019-11-1310.1107/S2052252519013137
6PS5AAmineAdrenergicβ2Homo sapiens(S)-Propranolol--2.92019-11-1310.1107/S2052252519013137
6PS6AAmineAdrenergicβ2Homo sapiensTimolol--2.72019-11-1310.1107/S2052252519013137
7BZ2AAmineAdrenergicβ2Homo sapiensArformoterol-Gs/&β;1/&γ;23.822020-08-0510.1038/s41421-020-0176-9
7DHIAAmineAdrenergicβ2Homo sapiensSalbutamol-Gs/&β;1/&γ;23.262020-12-1610.1093/nsr/nwaa284
7DHRAAmineAdrenergicβ2Homo sapiensIsoprenaline-Gs/&β;1/&γ;23.82020-12-1610.1093/nsr/nwaa284
7XKAAAmineAdrenergicβ2Homo sapiensEpinephrine--3.12023-04-2610.1038/s41467-023-37808-y
8GDZAAmineAdrenergicβ2Homo sapiensEpinephrine-Gs/&β;1/&γ;23.52024-03-0610.1038/s41586-024-07153-1
8GE1AAmineAdrenergicβ2Homo sapiensEpinephrine-Gs/&β;1/&γ;23.42024-03-0610.1038/s41586-024-07153-1
8GE3AAmineAdrenergicβ2Homo sapiensEpinephrine-Gs/&β;1/&γ;23.32024-03-0610.1038/s41586-024-07153-1
8GE4AAmineAdrenergicβ2Homo sapiensEpinephrine-Gs/&β;1/&γ;23.32024-03-0610.1038/s41586-024-07153-1
8GE6AAmineAdrenergicβ2Homo sapiensEpinephrine-Gs/&β;1/&γ;23.42024-03-0610.1038/s41586-024-07153-1
8GE7AAmineAdrenergicβ2Homo sapiensEpinephrine-Gs/&β;1/&γ;23.42024-03-0610.1038/s41586-024-07153-1
8GE8AAmineAdrenergicβ2Homo sapiensEpinephrine-Gs/&β;1/&γ;23.42024-03-0610.1038/s41586-024-07153-1
8GE9AAmineAdrenergicβ2Homo sapiensEpinephrine-Gs/&β;1/&γ;23.52024-03-0610.1038/s41586-024-07153-1
8GEAAAmineAdrenergicβ2Homo sapiensEpinephrine-Gs/&β;1/&γ;23.52024-03-0610.1038/s41586-024-07153-1
8GEBAAmineAdrenergicβ2Homo sapiensEpinephrine-Gs/&β;1/&γ;23.62024-03-0610.1038/s41586-024-07153-1
8GECAAmineAdrenergicβ2Homo sapiensEpinephrine-Gs/&β;1/&γ;23.52024-03-0610.1038/s41586-024-07153-1
8GEDAAmineAdrenergicβ2Homo sapiensEpinephrine-Gs/&β;1/&γ;23.52024-03-0610.1038/s41586-024-07153-1
8GEEAAmineAdrenergicβ2Homo sapiensEpinephrine-Gs/&β;1/&γ;23.72024-03-0610.1038/s41586-024-07153-1
8GEFAAmineAdrenergicβ2Homo sapiensEpinephrine-Gs/&β;1/&γ;23.82024-03-0610.1038/s41586-024-07153-1
8GEGAAmineAdrenergicβ2Homo sapiensEpinephrine-Gs/&β;1/&γ;23.82024-03-0610.1038/s41586-024-07153-1
8GEHAAmineAdrenergicβ2Homo sapiensEpinephrine-Gs/&β;1/&γ;242024-03-0610.1038/s41586-024-07153-1
8GEIAAmineAdrenergicβ2Homo sapiensEpinephrine-Gs/&β;1/&γ;24.12024-03-0610.1038/s41586-024-07153-1
8GEJAAmineAdrenergicβ2Homo sapiensEpinephrine-Gs/&β;1/&γ;24.22024-03-0610.1038/s41586-024-07153-1
8GFVAAmineAdrenergicβ2Homo sapiensEpinephrineGTPGs/&β;1/&γ;23.12024-03-0610.1038/s41586-024-07153-1
8GFWAAmineAdrenergicβ2Homo sapiensEpinephrineGTPGs/&β;1/&γ;232024-03-0610.1038/s41586-024-07153-1
8GFXAAmineAdrenergicβ2Homo sapiensEpinephrineGTPGs/&β;1/&γ;232024-03-0610.1038/s41586-024-07153-1
8GFYAAmineAdrenergicβ2Homo sapiensEpinephrineGTPGs/&β;1/&γ;232024-03-0610.1038/s41586-024-07153-1
8GFZAAmineAdrenergicβ2Homo sapiensEpinephrineGTPGs/&β;1/&γ;232024-03-0610.1038/s41586-024-07153-1
8GG0AAmineAdrenergicβ2Homo sapiensEpinephrineGTPGs/&β;1/&γ;22.92024-03-0610.1038/s41586-024-07153-1
8GG1AAmineAdrenergicβ2Homo sapiensEpinephrineGTPGs/&β;1/&γ;232024-03-0610.1038/s41586-024-07153-1
8GG2AAmineAdrenergicβ2Homo sapiensEpinephrineGTPGs/&β;1/&γ;232024-03-0610.1038/s41586-024-07153-1
8GG3AAmineAdrenergicβ2Homo sapiensEpinephrineGTPGs/&β;1/&γ;23.12024-03-0610.1038/s41586-024-07153-1
8GG4AAmineAdrenergicβ2Homo sapiensEpinephrineGTPGs/&β;1/&γ;23.22024-03-0610.1038/s41586-024-07153-1
8GG5AAmineAdrenergicβ2Homo sapiensEpinephrineGTPGs/&β;1/&γ;23.22024-03-0610.1038/s41586-024-07153-1
8GG6AAmineAdrenergicβ2Homo sapiensEpinephrineGTPGs/&β;1/&γ;23.32024-03-0610.1038/s41586-024-07153-1
8GG7AAmineAdrenergicβ2Homo sapiensEpinephrineGTPGs/&β;1/&γ;23.32024-03-0610.1038/s41586-024-07153-1
8GG8AAmineAdrenergicβ2Homo sapiensEpinephrineGTPGs/&β;1/&γ;23.32024-03-0610.1038/s41586-024-07153-1
8GG9AAmineAdrenergicβ2Homo sapiensEpinephrineGTPGs/&β;1/&γ;23.42024-03-0610.1038/s41586-024-07153-1
8GGAAAmineAdrenergicβ2Homo sapiensEpinephrineGTPGs/&β;1/&γ;23.52024-03-0610.1038/s41586-024-07153-1
8GGBAAmineAdrenergicβ2Homo sapiensEpinephrineGTPGs/&β;1/&γ;23.52024-03-0610.1038/s41586-024-07153-1
8GGCAAmineAdrenergicβ2Homo sapiensEpinephrineGTPGs/&β;1/&γ;23.42024-03-0610.1038/s41586-024-07153-1
8GGEAAmineAdrenergicβ2Homo sapiensEpinephrineGTPGs/&β;1/&γ;23.52024-03-0610.1038/s41586-024-07153-1
8GGFAAmineAdrenergicβ2Homo sapiensEpinephrineGTPGs/&β;1/&γ;23.62024-03-0610.1038/s41586-024-07153-1
8GGIAAmineAdrenergicβ2Homo sapiensEpinephrine--3.52024-03-0610.1038/s41586-024-07153-1
8GGJAAmineAdrenergicβ2Homo sapiensEpinephrine--3.52024-03-0610.1038/s41586-024-07153-1
8GGKAAmineAdrenergicβ2Homo sapiensEpinephrine--3.32024-03-0610.1038/s41586-024-07153-1
8GGLAAmineAdrenergicβ2Homo sapiensEpinephrine--3.22024-03-0610.1038/s41586-024-07153-1
8GGMAAmineAdrenergicβ2Homo sapiensEpinephrine--3.22024-03-0610.1038/s41586-024-07153-1
8GGNAAmineAdrenergicβ2Homo sapiensEpinephrine--3.32024-03-0610.1038/s41586-024-07153-1
8GGOAAmineAdrenergicβ2Homo sapiensEpinephrine--3.22024-03-0610.1038/s41586-024-07153-1
8GGPAAmineAdrenergicβ2Homo sapiensEpinephrine--3.22024-03-0610.1038/s41586-024-07153-1
8GGQAAmineAdrenergicβ2Homo sapiensEpinephrine--3.42024-03-0610.1038/s41586-024-07153-1
8GGRAAmineAdrenergicβ2Homo sapiensEpinephrine--3.42024-03-0610.1038/s41586-024-07153-1
8GGSAAmineAdrenergicβ2Homo sapiensEpinephrine--3.52024-03-0610.1038/s41586-024-07153-1
8GGTAAmineAdrenergicβ2Homo sapiensEpinephrine--3.52024-03-0610.1038/s41586-024-07153-1
8GGUAAmineAdrenergicβ2Homo sapiensEpinephrine--3.42024-03-0610.1038/s41586-024-07153-1
8GGVAAmineAdrenergicβ2Homo sapiensEpinephrine--3.52024-03-0610.1038/s41586-024-07153-1
8GGWAAmineAdrenergicβ2Homo sapiensEpinephrine--3.62024-03-0610.1038/s41586-024-07153-1
8GGXAAmineAdrenergicβ2Homo sapiensEpinephrine--3.62024-03-0610.1038/s41586-024-07153-1
8GGYAAmineAdrenergicβ2Homo sapiensEpinephrine--3.92024-03-0610.1038/s41586-024-07153-1
8GGZAAmineAdrenergicβ2Homo sapiensEpinephrine--3.92024-03-0610.1038/s41586-024-07153-1
8GH0AAmineAdrenergicβ2Homo sapiensEpinephrine--42024-03-0610.1038/s41586-024-07153-1
8GH1AAmineAdrenergicβ2Homo sapiensEpinephrine--4.12024-03-0610.1038/s41586-024-07153-1
8JJ8AAmineAdrenergicβ2Homo sapiensFormoterol--3.22023-09-0610.1038/s41589-023-01389-0
8JJLAAmineAdrenergicβ2Homo sapiensOlodaterol--3.22023-09-0610.1038/s41589-023-01389-0
8JJOAAmineAdrenergicβ2Homo sapiensAlprenolol--3.42023-09-0610.1038/s41589-023-01389-0
8UNLAAmineAdrenergicβ2Homo sapiensEpinephrineGTPGs/&β;1/&γ;23.32024-03-0610.1038/s41586-024-07153-1
8UNMAAmineAdrenergicβ2Homo sapiensEpinephrineGTPGs/&β;1/&γ;23.42024-03-0610.1038/s41586-024-07153-1
8UNNAAmineAdrenergicβ2Homo sapiensEpinephrineGTPGs/&β;1/&γ;23.42024-03-0610.1038/s41586-024-07153-1
8UNOAAmineAdrenergicβ2Homo sapiensEpinephrineGTPGs/&β;1/&γ;23.32024-03-0610.1038/s41586-024-07153-1
8UNPAAmineAdrenergicβ2Homo sapiensEpinephrineGTPGs/&β;1/&γ;23.32024-03-0610.1038/s41586-024-07153-1
8UNQAAmineAdrenergicβ2Homo sapiensEpinephrineGTPGs/&β;1/&γ;23.32024-03-0610.1038/s41586-024-07153-1
8UNRAAmineAdrenergicβ2Homo sapiensEpinephrineGTPGs/&β;1/&γ;23.42024-03-0610.1038/s41586-024-07153-1
8UNSAAmineAdrenergicβ2Homo sapiensEpinephrineGTPGs/&β;1/&γ;23.42024-03-0610.1038/s41586-024-07153-1
8UNTAAmineAdrenergicβ2Homo sapiensEpinephrineGTPGs/&β;1/&γ;23.42024-03-0610.1038/s41586-024-07153-1
8UNUAAmineAdrenergicβ2Homo sapiensEpinephrineGTPGs/&β;1/&γ;23.52024-03-0610.1038/s41586-024-07153-1
8UNVAAmineAdrenergicβ2Homo sapiensEpinephrineGTPGs/&β;1/&γ;23.32024-03-0610.1038/s41586-024-07153-1
8UNWAAmineAdrenergicβ2Homo sapiensEpinephrineGTPGs/&β;1/&γ;23.42024-03-0610.1038/s41586-024-07153-1
8UNXAAmineAdrenergicβ2Homo sapiensEpinephrineGTPGs/&β;1/&γ;23.62024-03-0610.1038/s41586-024-07153-1
8UNYAAmineAdrenergicβ2Homo sapiensEpinephrineGTPGs/&β;1/&γ;23.62024-03-0610.1038/s41586-024-07153-1
8UNZAAmineAdrenergicβ2Homo sapiensEpinephrineGTPGs/&β;1/&γ;23.82024-03-0610.1038/s41586-024-07153-1
8UO0AAmineAdrenergicβ2Homo sapiensEpinephrineGTPGs/&β;1/&γ;23.52024-03-0610.1038/s41586-024-07153-1
8UO1AAmineAdrenergicβ2Homo sapiensEpinephrineGTP; MgGs/&β;1/&γ;23.62024-03-0610.1038/s41586-024-07153-1
8UO2AAmineAdrenergicβ2Homo sapiensEpinephrineGTPGs/&β;1/&γ;23.62024-03-0610.1038/s41586-024-07153-1
8UO3AAmineAdrenergicβ2Homo sapiensEpinephrineGTP; MgGs/&β;1/&γ;23.52024-03-0610.1038/s41586-024-07153-1
8UO4AAmineAdrenergicβ2Homo sapiensEpinephrineGTP; MgGs/&β;1/&γ;242024-03-0610.1038/s41586-024-07153-1




You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download 6OBA.zip



You can click to copy the link of this page to easily come back here later

or use this QR code to link and share this page.



You can also  read or  download a guide explaining the meaning of all files and numerical data.