Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg Int. Strength Num Of Links Community ConSurf
1A:A:Y37 5.795414
2A:A:H41 4.29576
3A:A:L44 5.5225419
4A:A:S51 2.8625409
5A:A:I56 4.8545117
6A:A:V217 3.3125475
7A:A:F219 4.72833678
8A:A:M221 4.27408
9A:A:F222 8.735407
10A:A:Q227 4.44429719
11A:A:K233 6.68333619
12A:A:W234 5.37419
13A:A:F238 6.14519
14A:A:I245 3.52407
15A:A:V247 3.33407
16A:A:V248 4.54407
17A:A:D249 7.8554178
18A:A:D252 6.0354178
19A:A:F273 4.565659
20A:A:W277 8.732556
21A:A:W281 11.12415
22A:A:I288 4.975409
23A:A:F290 3.56119
24A:A:L291 4.33458
25A:A:N292 4.46754119
26A:A:Q294 5.99556
27A:A:V334 2.3525404
28A:A:Y339 4.7575453
29A:A:F340 9.1525407
30A:A:R342 7.19454
31A:A:E344 4.7925405
32A:A:F345 6.236508
33A:A:S349 4.12557
34A:A:C359 3.418555
35A:A:Y360 5.7865188
36A:A:F363 6.892555
37A:A:T364 5.198336119
38A:A:R373 3.525475
39A:A:F376 4.97878
40A:A:I382 5.90254186
41A:A:I383 3.08478
42A:A:L388 2.8425408
43A:A:Y391 6.544504
44A:A:L393 3.8754198
45B:B:M45 6.105434
46B:B:R48 4.60754137
47B:B:L51 7.1775409
48B:B:H54 7.05857719
49B:B:L55 7.1925416
50B:B:K57 10.368519
51B:B:Y59 8.84418
52B:B:W63 6.5625217
53B:B:S72 5.3419
54B:B:Q75 7.09619
55B:B:D76 5.95619
56B:B:L79 3.6675497
57B:B:I80 6.125418
58B:B:I81 5.654597
59B:B:W82 9.07619
60B:B:K89 7.4575419
61B:B:L95 5.3725498
62B:B:W99 9.835419
63B:B:M101 3.9925419
64B:B:Y105 4.202596
65B:B:Y111 6.535404
66B:B:L117 3.482519
67B:B:I120 4.54754226
68B:B:I123 4.18254156
69B:B:E138 6.4054226
70B:B:H142 7.1725109
71B:B:Y145 5.56875818
72B:B:R150 4.0825406
73B:B:F151 5.426676159
74B:B:L152 4.3525403
75B:B:T159 5.48254109
76B:B:C166 4.235488
77B:B:L168 5.1025486
78B:B:W169 6.535717108
79B:B:D170 3.60254249
80B:B:F180 7.08333687
81B:B:H183 8.545409
82B:B:D186 8.112519
83B:B:M188 4.51518
84B:B:L190 4.3775405
85B:B:L198 3.4954253
86B:B:F199 7.008589
87B:B:V200 6.53426
88B:B:S201 4.6225489
89B:B:C204 5.945417
90B:B:K209 10.332586
91B:B:L210 6.23405
92B:B:W211 9.43588
93B:B:Q220 7.1675427
94B:B:F222 6.27528
95B:B:H225 7.39429729
96B:B:D228 6.3225419
97B:B:I229 4.365427
98B:B:I232 4.67143728
99B:B:F234 4.902525
100B:B:F235 7.524526
101B:B:P236 6.0025427
102B:B:N237 7.605425
103B:B:F241 5.57626
104B:B:T243 6.104528
105B:B:D247 7.6775429
106B:B:T249 5.885426
107B:B:R251 10.976528
108B:B:F253 9.624526
109B:B:D254 5.37254269
110B:B:R256 6.1665269
111B:B:E260 10.8625406
112B:B:Y264 5.495625
113B:B:F278 3.35667627
114B:B:R283 5.594289
115B:B:Y289 6.24667627
116B:B:C294 4.215435
117B:B:V296 2.835635
118B:B:W297 8.685428
119B:B:L308 5.6625437
120B:B:H311 7.515439
121B:B:R314 8.152518
122B:B:V327 4.7575406
123B:B:T329 5.76438
124B:B:W332 6.45667619
125B:B:L336 6.3875417
126B:B:K337 5.112536
127B:B:W339 5.966539
128G:G:Q18 6.2825489
129G:G:Y40 10.25426
130R:R:F569 4.46833669
131R:R:S574 4.065409
132R:R:I581 3.44294
133R:R:L593 4.3475468
134R:R:I597 2.9775407
135R:R:T619 6.5375408
136R:R:R624 4.7775409
137R:R:L634 5.7975409
138R:R:D638 4.2775407
139R:R:F641 3.1625409
140R:R:H665 4.9154129
141R:R:F666 5.4525407
142R:R:Y668 5.235668
143R:R:L669 3.83754129
144R:R:L671 4.1185307
145R:R:W674 6.40833649
146R:R:M675 4.094309
147R:R:L678 3.43408
148R:R:L681 5.67407
149R:R:Y684 5.77448
150R:R:I686 2.9385207
151R:R:F690 5.32333678
152R:R:Q695 6.4575406
153R:R:M698 4.9625448
154R:R:G702 3.165447
155R:R:P710 4.7225129
156R:R:Y727 7.55754319
157R:R:L735 7.0625409
158R:R:W737 6.422506
159R:R:P743 4.602508
160R:R:P798 2.74254149
161R:R:L799 4.21406
162R:R:L800 3.5525409
163R:R:W804 7.78571769
164R:R:T810 4.55833667
165R:R:H820 7.7775468
166R:R:F823 5.80333669
167R:R:N827 9.885469
168R:R:F829 5.2625147
169R:R:F832 6.15754145
170R:R:F833 3.4265147
171W:W:?1 6.37111940
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
1A:A:L30 B:B:L55 35.55682.77NoYes156
2A:A:K34 B:B:L55 1005.64NoYes046
3A:A:K34 R:R:Q695 71.04756.78NoYes046
4B:B:D76 B:B:L55 64.684210.86YesYes196
5A:A:K34 A:A:R38 29.22727.43NoNo044
6A:A:Y37 B:B:D76 54.0623.45YesYes149
7A:A:Y37 B:B:Q75 52.52933.38YesYes149
8A:A:R38 R:R:H692 29.0557.9NoNo046
9A:A:H41 R:R:H692 29.00573.58YesNo066
10A:A:F219 A:A:H41 39.37354.53YesYes786
11A:A:H41 A:A:I383 15.41372.65YesYes768
12A:A:F212 A:A:F219 37.62668.57NoYes098
13A:A:F212 A:A:M221 37.17262.49NoYes098
14A:A:I245 A:A:M221 36.24672.92YesYes078
15B:B:Q75 B:B:W99 48.10339.86YesYes199
16A:A:S51 A:A:V247 25.11113.23YesYes097
17A:A:F290 A:A:V247 25.7162.62YesYes097
18A:A:F290 A:A:I245 34.84232.51YesYes097
19A:A:D249 A:A:S51 23.89742.94YesYes089
20B:B:L117 B:B:W99 46.49083.42YesYes199
21B:B:L117 B:B:Y145 45.64773.52YesYes198
22A:A:E230 A:A:K233 37.61416.75NoYes199
23A:A:K233 B:B:Y145 36.54533.58YesYes198
24A:A:E230 A:A:R228 37.59535.82NoNo099
25A:A:R228 B:B:T164 37.47195.17NoNo096
26A:A:L291 A:A:Q294 13.58775.32YesYes586
27A:A:Q294 A:A:S250 20.30555.78YesNo066
28A:A:L297 A:A:S250 20.54786.01NoNo086
29A:A:L297 A:A:S251 21.03164.5NoNo089
30A:A:L296 A:A:S251 21.51479.01NoNo069
31A:A:K293 A:A:L296 22.23774.23NoNo096
32A:A:D249 A:A:K293 22.47829.68YesNo089
33A:A:I383 A:A:N387 16.12612.83YesNo088
34R:R:M699 R:R:Q695 70.67724.08NoYes076
35R:R:I625 R:R:M699 70.21112.92NoNo477
36R:R:I625 W:W:?1 70.20383.47NoYes470
37A:A:Y391 R:R:L681 13.4724.69YesYes047
38A:A:N387 R:R:R685 16.04359.64NoNo088
39R:R:C626 W:W:?1 60.60772.57NoYes070
40R:R:C626 R:R:L678 59.82523.17NoYes078
41R:R:L678 R:R:L799 58.62784.15YesYes086
42R:R:L799 R:R:L800 14.86562.77YesYes069
43R:R:G679 R:R:L678 15.11241.71NoYes098
44R:R:G679 R:R:L800 14.59311.71NoYes099
45B:B:K89 B:B:W82 35.252613.92YesYes199
46B:B:S72 B:B:W82 35.24464.94YesYes199
47B:B:M61 B:B:S72 93.24343.07NoYes069
48B:B:L70 B:B:M61 92.97785.65NoNo056
49B:B:L70 B:B:W63 92.47489.11NoYes2157
50B:B:T321 B:B:W63 92.17610.92NoYes077
51B:B:D323 B:B:T321 91.77237.23NoNo077
52B:B:D323 B:B:M325 91.50215.54NoNo075
53B:B:M325 G:G:P49 91.36676.71NoNo057
54G:G:D48 G:G:P49 91.23113.22NoNo097
55B:B:S279 G:G:D48 10.8964.42NoNo099
56B:B:D76 B:B:S74 58.62784.42YesNo099
57B:B:H54 B:B:S74 58.569712.55YesNo099
58B:B:G185 B:B:T164 37.34841.82NoNo056
59B:B:D205 B:B:G185 37.22475.03NoNo095
60B:B:D205 B:B:S207 36.97664.42NoNo095
61B:B:H183 B:B:S207 36.72765.58YesNo095
62B:B:H183 B:B:S201 25.82332.79YesYes099
63B:B:F199 B:B:L190 21.28356.09YesYes095
64B:B:L190 B:B:R150 27.17692.43YesYes056
65B:B:H62 B:B:R150 25.39174.51NoYes066
66B:B:F199 B:B:W211 15.706110.02YesYes898
67B:B:H183 B:B:K209 10.661917.03YesYes096
68B:B:H62 B:B:Y105 24.79342.18NoYes066
69B:B:V71 B:B:Y105 16.96577.57NoYes986
70B:B:L79 B:B:V71 15.75742.98YesNo978
71B:B:L79 B:B:L95 12.14585.54YesYes978
72B:B:G162 B:B:Y145 12.93322.9NoYes198
73B:B:G162 B:B:S161 14.96963.71NoNo099
74B:B:H142 B:B:S161 13.143116.74YesNo099
75B:B:S281 G:G:D48 84.480210.31NoNo099
76B:B:G282 B:B:S281 84.33451.86NoNo099
77B:B:G282 B:B:P236 50.89584.06NoYes297
78B:B:F235 B:B:P236 26.035910.11YesYes267
79B:B:F235 B:B:N237 47.975412.08YesYes265
80B:B:G238 B:B:N237 66.14233.39NoYes275
81B:B:F234 B:B:G238 64.99343.01YesNo257
82B:B:F234 B:B:S191 17.41943.96YesNo058
83B:B:I232 B:B:S191 16.84334.64YesNo088
84B:B:F278 B:B:G282 33.29273.01YesNo279
85B:B:F235 B:B:F278 26.50576.43YesYes267
86B:B:P236 G:G:Y40 24.71486.95YesYes276
87B:B:N237 G:G:Y40 23.80258.14YesYes256
88B:B:F234 B:B:V200 46.449810.49YesYes256
89B:B:I232 B:B:V200 16.86694.61YesYes286
90B:B:F241 B:B:V200 22.09666.55YesYes266
91B:B:I229 B:B:I232 15.11282.94YesYes278
92B:B:F241 B:B:F253 12.21816.43YesYes266
93B:B:H225 B:B:I229 13.95387.95YesYes297
94B:B:I232 B:B:T243 15.11357.6YesYes288
95B:B:H225 B:B:T243 20.93158.21YesYes298
96B:B:D247 B:B:H225 13.96533.78YesYes299
97B:B:H225 B:B:R251 17.457914.67YesYes298
98R:R:I630 R:R:L799 43.60322.85NoYes086
99R:R:I630 R:R:L671 43.03752.85NoYes3087
100R:R:L634 R:R:L671 10.18745.54YesYes097
101R:R:F672 R:R:L671 21.84484.87NoYes097
102R:R:F672 R:R:W804 21.459119.04NoYes099
103R:R:T664 R:R:Y668 10.2422.5NoYes078
104R:R:L671 R:R:S633 11.52664.5YesNo078
105R:R:S633 R:R:S670 11.32244.89NoNo088
106R:R:P710 R:R:S670 11.12493.56YesNo098
107R:R:F666 R:R:P710 11.43672.89YesYes079
108R:R:L800 R:R:N758 24.88248.24YesNo099
109R:R:I754 R:R:N758 24.30534.25NoNo099
110R:R:F673 R:R:I754 23.13353.77NoNo089
111R:R:F673 R:R:P710 21.969510.11NoYes1289
112R:R:L669 R:R:P710 21.35143.28YesYes1299
113R:R:H665 R:R:L669 18.98725.14YesYes1299
114R:R:L735 R:R:P743 14.03746.57YesYes098
115R:R:G740 R:R:P743 11.14186.09NoYes048
116A:A:L30 B:B:K89 35.27222.82NoYes159
117B:B:H54 B:B:S72 57.55834.18YesYes199
118A:A:Y391 R:R:L678 14.02134.69YesYes048
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


2D representation of the interactions of this orthosteric/allosteric ligand.


Links and nodes colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
A:A:Y391 R:R:L678 4.69 0 Yes Yes 4 8 2 2
A:A:Y391 R:R:L681 4.69 0 Yes Yes 4 7 2 1
R:R:H621 R:R:I625 3.98 4 No No 6 7 2 1
R:R:H621 R:R:M699 2.63 4 No No 6 7 2 2
R:R:L681 R:R:T622 2.95 0 Yes No 7 7 1 2
R:R:M698 R:R:T622 3.01 4 Yes No 8 7 1 2
R:R:I625 R:R:M699 2.92 4 No No 7 7 1 2
R:R:I625 W:W:?1 3.47 4 No Yes 7 0 1 0
R:R:C626 R:R:W674 2.61 0 No Yes 7 9 1 2
R:R:C626 R:R:L678 3.17 0 No Yes 7 8 1 2
R:R:C626 W:W:?1 2.57 0 No Yes 7 0 1 0
R:R:G702 R:R:W674 2.81 4 Yes Yes 7 9 1 2
R:R:G702 R:R:M677 5.24 4 Yes No 7 6 1 1
R:R:L705 R:R:M677 5.65 0 No No 6 6 2 1
R:R:M677 W:W:?1 9.16 4 No Yes 6 0 1 0
R:R:I680 W:W:?1 15.03 0 No Yes 8 0 1 0
R:R:L681 R:R:R685 6.07 0 Yes No 7 8 1 2
R:R:L681 W:W:?1 8.97 0 Yes Yes 7 0 1 0
R:R:L688 R:R:Y684 5.86 4 No Yes 6 8 1 1
R:R:M693 R:R:Y684 9.58 4 No Yes 5 8 2 1
R:R:M698 R:R:Y684 4.79 4 Yes Yes 8 8 1 1
R:R:Y684 W:W:?1 2.85 4 Yes Yes 8 0 1 0
R:R:L688 W:W:?1 3.36 4 No Yes 6 0 1 0
R:R:M693 R:R:M698 2.89 4 No Yes 5 8 2 1
R:R:M698 W:W:?1 9.16 4 Yes Yes 8 0 1 0
R:R:G702 W:W:?1 2.77 4 Yes Yes 7 0 1 0
R:R:G702 R:R:V701 1.84 4 Yes No 7 6 1 2
R:R:H691 R:R:L688 1.29 0 No No 7 6 2 1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

ShowSimilarityNetwork TypeNameLigandDescription
69.23Single7WU4K6G7WU4-ADGRF1-K6G-Gi1/β1/γ2
58.33Single7WU3K6G7WU3-ADGRF1-K6G-Gs/β1/γ2
40.00Single5XSZGlyceryl-mono-oleate5XSZ-LPA6-Glyceryl-mono-oleate
40.00Single7WU5K6G7WU5-ADGRF1-K6G-Gi1/β1/γ2
30.77Single9K1CDHA9K1C-FFA1-DHA-Gi1/β1/γ2
28.57Single5KW2PubChem 1330539535KW2-FFA1-PubChem 133053953
25.00Single9K1DCholesterol9K1D-FFA2-Butanoic acid-Cholesterol-Gi1/β1/γ2
23.53Single9IYBA1D5Q9IYB-DP2-Prostaglandin-A1D5Q-Gi1/β1/γ2
23.08Single8XXUA1D5Q8XXU-DP2-A1D5Q-Gi1/β1/γ2
19.05Single5TZYMK8666; PubChem 1270535975TZY-FFA1-MK8666; PubChem 127053597
18.75Single6N48PubChem 1384542566N48-β2-BI167107-PubChem 138454256
15.79Single8XXVA1D5Q8XXV-DP2-Indomethacin-A1D5Q-Gi1/β1/γ2
15.38Single8U4PCholesterol8U4P-CXCR4-AMD3100-Cholesterol-Gi1/β1/γ2
13.33Single7CKZMevidalen7CKZ-D1-Dopamine-Mevidalen-Gs/β1/γ2
13.33Single7LJDMevidalen7LJD-D1-Dopamine-Mevidalen-Gs/β1/γ1
13.33Single7X2FMevidalen7X2F-D1-Dopamine-Mevidalen-Gs/β1/γ2
13.33Single8K9LVV98K9L-μ-Damgo-VV9-Gi3/β1/γ1
13.33Single8U4QCholesterol8U4Q-CXCR4-REGN7663-Fab-Cholesterol-Gi1/β1/γ2
12.50Single7LJCMevidalen7LJC-D1-SKF-81297-Mevidalen-Gs/β1/γ2
11.11Single6C1RAvacopan; Na6C1R-C5a1-PMX53-Avacopan; Na
9.52Single7SHEPI; PE7SHE-GPR158-PI; PE
8.33Single4PXFOctyl-Beta-D-Glucopyranoside4PXF-Rhodopsin-Octyl-β-D-Glucopyranoside-Arrestin1 Finger Loop
8.00Single7SHEPI; PE7SHE-GPR158-PI; PE
8.00Single7SHFPI; PE7SHF-GPR158-PI; PE-B5; RGS7
7.69Single8U4NCholesterol8U4N-CXCR4-Cholesterol-Gi1/β1/γ2
7.14Single6KQIOrg275696KQI-CB1-CP55940-Org27569
6.67Single6OBAGTPL110746OBA-β2-S-Alprenolol-GTPL11074
6.67Single8U4OCholesterol8U4O-CXCR4-CXCL12-Cholesterol-Gi1/β1/γ2
6.67Single8U4RCholesterol8U4R-CXCR4-REGN7663-Fab-Cholesterol
5.88Single6C1QNDT95137276C1Q-C5a1-PMX53-NDT9513727
5.88Single8G94CD698G94-S1P1-CD69-Gi1/β1/γ2
5.56Single5O9HNDT95137275O9H-C5a1-NDT9513727
5.56Single8IYXYL-3658IYX-GPR34-YL-365
4.35Single7SHFPI; PE7SHF-GPR158-PI; PE-B5; RGS7

PDB Summary
PDB 8G2Y
Class B2
SubFamily Adhesion
Type Adhesion
SubType ADGRF1
Species Homo Sapiens
Ligand -
Other Ligand(s) LPC
Protein Partners chim(Gs-CtGq)/Beta1/Gamma2
PDB Resolution 3.44
Date 2023-05-10
D.O.I. 10.1038/s41467-023-38083-7
Net Summary
Imin 2.49
Number of Linked Nodes 729
Number of Links 928
Number of Hubs 171
Number of Links mediated by Hubs 606
Number of Communities 31
Number of Nodes involved in Communities 246
Number of Links involved in Communities 355
Path Summary
Number Of Nodes in MetaPath 119
Number Of Links MetaPath 118
Number of Shortest Paths 1568349
Length Of Smallest Path 3
Average Path Length 33.1277
Length of Longest Path 57
Minimum Path Strength 1.22
Average Path Strength 5.6358
Maximum Path Strength 18.635
Minimum Path Correlation 0.7
Average Path Correlation 0.982127
Maximum Path Correlation 1
Minimum % Of Corr. Nodes 2.7027
Average % Of Corr. Nodes 38.1477
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 51.805
Maximum Path Hubs % 100
AnnotationTypeLinks
Gene OntologyMolecular Function
Gene OntologyBiological Process
Gene OntologyCellular Component
SCOP2Domain Identifier
SCOP2Family Identifier
Membrane Protein Annotations-• Orientations of Proteins in Membranes database (OPM)   • Protein Data Bank of Transmembrane Proteins (PDBTM)   • MemProtMD


Details about the values in these tables can be found in the corresponding documentation page .
CodeLPC
PDB ResiduesW:W:?1
Environment DetailsOpen EMBL-EBI Page
CodeLPC
Name[1-MYRISTOYL-GLYCEROL-3-YL]PHOSPHONYLCHOLINE
Synonyms
Identifier
FormulaC22 H47 N O7 P
Molecular Weight468.585
SMILES
PubChem444675
Formal Charge1
Total Atoms78
Total Chiral Atoms2
Total Bonds77
Total Aromatic Bonds0

PDBsumOpen PDBsum Page
ChainA
ProteinG Protein α Sub unit
UniProtP63092
Sequence
>8G2Y_Chain_A
KIEKQLQKD KQVYRATHR LLLLGADNS GKSTIIFET KFQVDKVNF 
HMFDVGGQR DERRKWIQC FNDVTAIIF VVDSSDYNR LQEALNLFK 
SIWNNRWLR TISVILFLN KQDLLAEKV LAYFPEFAR YTTPDPRVT 
RAKYFIRDE FLRISTASG DGRHYCYPH FTCAVDTEN ARRIFNDCK 
DIILQMNLR EYNLV


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainB
ProteinG Protein β Sub unit
UniProtP62873
Sequence
>8G2Y_Chain_B
GRIQMRTRR TLRGHLAKI YAMHWGLLV SASQDGKLI IWDSYTTNK 
VHAIPLRSS WVMTCAYAP SGNYVACGG LDNICSIYN LKVRVSREL 
AGHTGYLSC CRFLDDNQI VTSSGDTTC ALWDIETGQ QTTTFTGHT 
GDVMSLSLA PDTRLFVSG ACDASAKLW DVREGMCRQ TFTGHESDI 
NAICFFPNG NAFATGSDD ATCRLFDLR ADQELMTYS HDNIICGIT 
SVSFSKSGR LLLAGYDDF NCNVWDALK ADRAGVLAG HDNRVSCLG 
VTDDGMAVA TGSWDSFLK IWN


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainG
ProteinG Protein γ Sub unit
UniProtP59768
Sequence
>8G2Y_Chain_G
RKLVEQLKM EANIDRIKV SKAAADLMA YCEAHAKED PL


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainR
ProteinReceptor
UniProtQ5T601
Sequence
>8G2Y_Chain_R
TSFSILMSP FVPSTIFPV VKWITYVGL GISIGSLIL CLIIEALFW 
QTSHTRRIC MVNIALSLL IADVWFIVG ATVGVCTAA VFFTHFFYL 
SLFFWMLML GILLAYRII LVFHHMAQH LMMAVGFCL GYGCPLIIS 
VITIAVTQY KRKDVCWLN WSNGSKPLL AFVVPALAI VAVNFVVVL 
LVLTKLWTI IRVGKSLLI LTPLLGLTW GFGIGTIVD SQNLAWHVI 
FALLNAFQG FFILCFGIL LDSKLRQL


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  




This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
8G2YB2AdhesionAdhesionADGRF1Homo sapiens-LPCchim(Gs-CtGq)/β1/γ23.442023-05-1010.1038/s41467-023-38083-7
8G2Y (No Gprot) B2AdhesionAdhesionADGRF1Homo sapiens-LPC3.442023-05-1010.1038/s41467-023-38083-7
7WZ7B2AdhesionAdhesionADGRF1Homo sapiens--chim(NtGi1-G12)/β1/γ22.832022-09-2810.1038/s41467-022-33173-4
7WZ7 (No Gprot) B2AdhesionAdhesionADGRF1Homo sapiens--2.832022-09-2810.1038/s41467-022-33173-4
7WXUB2AdhesionAdhesionADGRF1Homo sapiens--chim(NtGi1-Gs-CtGq)/β1/γ22.852022-09-2810.1038/s41467-022-33173-4
7WXU (No Gprot) B2AdhesionAdhesionADGRF1Homo sapiens--2.852022-09-2810.1038/s41467-022-33173-4
7WXWB2AdhesionAdhesionADGRF1Homo sapiens--chim(NtGi1-Gs)/β1/γ22.842022-09-2810.1038/s41467-022-33173-4
7WXW (No Gprot) B2AdhesionAdhesionADGRF1Homo sapiens--2.842022-09-2810.1038/s41467-022-33173-4
7WY0B2AdhesionAdhesionADGRF1Homo sapiens--chim(NtGi1L-G13)/β1/γ22.832022-09-2810.1038/s41467-022-33173-4
7WY0 (No Gprot) B2AdhesionAdhesionADGRF1Homo sapiens--2.832022-09-2810.1038/s41467-022-33173-4
7X2VB2AdhesionAdhesionADGRF1Homo sapiens--Gi1/β1/γ23.092022-09-2810.1038/s41467-022-33173-4
7X2V (No Gprot) B2AdhesionAdhesionADGRF1Homo sapiens--3.092022-09-2810.1038/s41467-022-33173-4
7WU5B2AdhesionAdhesionADGRF1Homo sapiens-K6GGi1/β1/γ232022-04-2710.1038/s41586-022-04580-w
7WU5 (No Gprot) B2AdhesionAdhesionADGRF1Homo sapiens-K6G32022-04-2710.1038/s41586-022-04580-w
7WU4B2AdhesionAdhesionADGRF1Homo sapiens-K6GGi1/β1/γ23.42022-04-2710.1038/s41586-022-04580-w
7WU4 (No Gprot) B2AdhesionAdhesionADGRF1Homo sapiens-K6G3.42022-04-2710.1038/s41586-022-04580-w
7WU3B2AdhesionAdhesionADGRF1Homo sapiens-K6GGs/β1/γ23.12022-04-2710.1038/s41586-022-04580-w
7WU3 (No Gprot) B2AdhesionAdhesionADGRF1Homo sapiens-K6G3.12022-04-2710.1038/s41586-022-04580-w




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