psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	A:A:K25	A:A:K28	11.49	No	No	0	5	4
2	A:A:I26	A:A:L30	4.28	No	No	1	9	5
3	A:A:I26	B:B:K89	10.18	No	Yes	1	9	9
4	A:A:I26	B:B:A92	3.25	No	No	0	9	6
5	A:A:L30	B:B:L55	2.77	No	Yes	1	5	6
6	A:A:L30	B:B:K89	2.82	No	Yes	1	5	9
7	A:A:Q31	R:R:Q695	3.84	No	Yes	0	4	6
8	A:A:K32	A:A:Q35	6.78	No	No	0	4	3
9	A:A:K32	A:A:V36	7.59	No	No	0	4	2
10	A:A:D33	B:B:L55	9.5	No	Yes	1	5	6
11	A:A:D33	B:B:D76	5.32	No	Yes	1	5	9
12	A:A:D33	B:B:K78	13.83	No	No	1	5	8
13	A:A:K34	A:A:R38	7.43	No	No	0	4	4
14	A:A:K34	B:B:L55	5.64	No	Yes	0	4	6
15	A:A:K34	R:R:Q695	6.78	No	Yes	0	4	6
16	A:A:R42	A:A:Y37	12.35	No	Yes	1	9	4
17	A:A:Y37	B:B:A56	4	Yes	No	0	4	7
18	A:A:Y37	B:B:Q75	3.38	Yes	Yes	1	4	9
19	A:A:Y37	B:B:D76	3.45	Yes	Yes	1	4	9
20	A:A:R38	R:R:H692	7.9	No	No	0	4	6
21	A:A:H41	A:A:V217	2.77	Yes	Yes	7	6	5
22	A:A:F219	A:A:H41	4.53	Yes	Yes	7	8	6
23	A:A:H41	A:A:I383	2.65	Yes	Yes	7	6	8
24	A:A:H41	R:R:F690	7.92	Yes	Yes	7	6	8
25	A:A:H41	R:R:H692	3.58	Yes	No	0	6	6
26	A:A:F222	A:A:R42	5.34	Yes	No	0	7	9
27	A:A:R42	B:B:Q75	5.84	No	Yes	1	9	9
28	A:A:L43	A:A:M221	5.65	No	Yes	0	7	8
29	A:A:I375	A:A:L43	5.71	No	No	0	9	7
30	A:A:F238	A:A:L44	13.4	Yes	Yes	1	9	9
31	A:A:L44	A:A:V241	2.98	Yes	No	1	9	9
32	A:A:I244	A:A:L44	4.28	No	Yes	0	8	9
33	A:A:K53	A:A:L45	7.05	No	No	16	9	8
34	A:A:D223	A:A:L45	5.43	No	No	16	9	8
35	A:A:I245	A:A:L45	5.71	Yes	No	0	7	8
36	A:A:I244	A:A:L46	2.85	No	No	0	8	8
37	A:A:A48	A:A:S51	3.42	No	Yes	0	8	9
38	A:A:A48	A:A:R265	4.15	No	No	0	8	9
39	A:A:D249	A:A:N50	14.81	Yes	No	17	8	9
40	A:A:D252	A:A:N50	4.04	Yes	No	17	8	9
41	A:A:S51	A:A:V247	3.23	Yes	Yes	0	9	7
42	A:A:D249	A:A:S51	2.94	Yes	Yes	0	8	9
43	A:A:G52	A:A:N292	3.39	No	Yes	0	9	9
44	A:A:D223	A:A:K53	8.3	No	No	16	9	9
45	A:A:K53	A:A:V247	3.04	No	Yes	0	9	7
46	A:A:I56	A:A:T55	4.56	Yes	No	0	7	9
47	A:A:F290	A:A:I56	2.51	Yes	Yes	11	9	7
48	A:A:I56	A:A:N292	5.66	Yes	Yes	11	7	9
49	A:A:I56	A:A:T364	3.04	Yes	Yes	11	7	9
50	A:A:I56	A:A:N371	8.5	Yes	No	11	7	9
51	A:A:E209	A:A:I207	4.1	No	No	0	9	9
52	A:A:F222	A:A:I207	2.51	Yes	No	0	7	9
53	A:A:D223	A:A:F208	4.78	No	No	0	9	5
54	A:A:E209	A:A:H220	4.92	No	No	0	9	7
55	A:A:M221	A:A:T210	6.02	Yes	No	0	8	7
56	A:A:H220	A:A:K211	5.24	No	No	0	7	4
57	A:A:F212	A:A:F219	8.57	No	Yes	0	9	8
58	A:A:F212	A:A:M221	2.49	No	Yes	0	9	8
59	A:A:K216	A:A:Q213	2.71	No	No	0	4	3
60	A:A:N218	A:A:Q213	18.49	No	No	0	4	3
61	A:A:F219	A:A:V214	3.93	Yes	No	7	8	6
62	A:A:R373	A:A:V214	3.92	Yes	No	7	5	6
63	A:A:F376	A:A:V214	3.93	Yes	No	7	8	6
64	A:A:D215	A:A:R373	3.57	No	Yes	7	5	5
65	A:A:D215	A:A:F376	5.97	No	Yes	7	5	8
66	A:A:F219	A:A:V217	3.93	Yes	Yes	7	8	5
67	A:A:F376	A:A:V217	2.62	Yes	Yes	7	8	5
68	A:A:V217	R:R:F690	3.93	Yes	Yes	7	5	8
69	A:A:F219	A:A:F376	3.22	Yes	Yes	7	8	8
70	A:A:C379	A:A:F219	4.19	No	Yes	0	8	8
71	A:A:F222	A:A:H220	9.05	Yes	No	0	7	7
72	A:A:I245	A:A:M221	2.92	Yes	Yes	0	7	8
73	A:A:F222	B:B:W99	18.04	Yes	Yes	0	7	9
74	A:A:Q227	A:A:V224	2.87	Yes	No	1	9	9
75	A:A:V224	A:A:W234	4.9	No	Yes	1	9	9
76	A:A:Q227	A:A:W234	6.57	Yes	Yes	1	9	9
77	A:A:Q227	B:B:L117	3.99	Yes	Yes	1	9	9
78	A:A:Q227	B:B:N119	6.6	Yes	No	1	9	9
79	A:A:Q227	B:B:G144	4.93	Yes	No	1	9	8
80	A:A:Q227	B:B:Y145	4.51	Yes	Yes	1	9	8
81	A:A:E230	A:A:R228	5.82	No	No	0	9	9
82	A:A:R228	B:B:T164	5.17	No	No	0	9	6
83	A:A:D229	A:A:R231	3.57	No	No	0	8	9
84	A:A:E230	A:A:R232	6.98	No	No	1	9	8
85	A:A:E230	A:A:K233	6.75	No	Yes	1	9	9
86	A:A:R231	A:A:W234	7	No	Yes	0	9	9
87	A:A:L272	A:A:R231	8.5	No	No	0	8	9
88	A:A:K233	A:A:R232	3.71	Yes	No	1	9	8
89	A:A:R232	B:B:D228	11.91	No	Yes	1	8	9
90	A:A:K233	B:B:Y145	3.58	Yes	Yes	1	9	8
91	A:A:K233	B:B:D186	13.83	Yes	Yes	1	9	9
92	A:A:K233	B:B:M188	5.76	Yes	Yes	1	9	8
93	A:A:K233	B:B:C204	6.47	Yes	Yes	1	9	7
94	A:A:F238	A:A:W234	3.01	Yes	Yes	1	9	9
95	A:A:Q236	A:A:W281	6.57	No	Yes	1	8	5
96	A:A:Q236	B:B:R314	4.67	No	Yes	1	8	8
97	A:A:C237	B:B:Y59	9.41	No	Yes	0	8	8
98	A:A:C237	B:B:M101	4.86	No	Yes	0	8	9
99	A:A:F238	A:A:V241	2.62	Yes	No	1	9	9
100	A:A:F238	B:B:W99	8.02	Yes	Yes	1	9	9
101	A:A:F238	B:B:L117	3.65	Yes	Yes	1	9	9
102	A:A:D240	A:A:N239	4.04	No	No	1	6	8
103	A:A:N239	B:B:K57	9.79	No	Yes	1	8	9
104	A:A:N239	B:B:W332	11.3	No	Yes	1	8	9
105	A:A:D240	B:B:K57	15.21	No	Yes	1	6	9
106	A:A:D240	B:B:Q75	6.53	No	Yes	1	6	9
107	A:A:A243	A:A:I288	3.25	No	Yes	0	8	9
108	A:A:I244	A:A:I285	2.94	No	No	0	8	7
109	A:A:F290	A:A:I245	2.51	Yes	Yes	0	9	7
110	A:A:I245	A:A:I375	2.94	Yes	No	0	7	9
111	A:A:F246	A:A:V248	5.24	No	Yes	0	9	7
112	A:A:F246	A:A:I276	3.77	No	No	0	9	8
113	A:A:F290	A:A:V247	2.62	Yes	Yes	0	9	7
114	A:A:N292	A:A:V247	4.43	Yes	Yes	0	9	7
115	A:A:A269	A:A:V248	3.39	No	Yes	0	9	7
116	A:A:L291	A:A:V248	2.98	Yes	Yes	0	8	7
117	A:A:F345	A:A:V248	6.55	Yes	Yes	0	8	7
118	A:A:D249	A:A:D252	3.99	Yes	Yes	17	8	8
119	A:A:D249	A:A:K293	9.68	Yes	No	0	8	9
120	A:A:Q294	A:A:S250	5.78	Yes	No	0	6	6
121	A:A:L297	A:A:S250	6.01	No	No	0	8	6
122	A:A:L296	A:A:S251	9.01	No	No	0	6	9
123	A:A:L297	A:A:S251	4.5	No	No	0	8	9
124	A:A:K300	A:A:S251	4.59	No	No	0	9	9
125	A:A:D252	A:A:N264	5.39	Yes	No	0	8	9
126	A:A:D252	A:A:R265	10.72	Yes	No	0	8	9
127	A:A:L297	A:A:Y253	3.52	No	No	0	8	8
128	A:A:N264	A:A:Y311	12.79	No	No	0	9	6
129	A:A:E268	A:A:R265	10.47	No	No	0	9	9
130	A:A:F312	A:A:L266	3.65	No	No	0	8	8
131	A:A:I341	A:A:L266	5.71	No	No	0	8	8
132	A:A:L270	A:A:Q267	2.66	No	No	0	6	4
133	A:A:N271	A:A:Q267	9.24	No	No	0	5	4
134	A:A:E344	A:A:L270	2.65	Yes	No	0	5	6
135	A:A:F345	A:A:L270	8.53	Yes	No	0	8	6
136	A:A:F273	A:A:W277	8.02	Yes	Yes	5	9	6
137	A:A:F273	A:A:V287	3.93	Yes	No	5	9	6
138	A:A:F273	A:A:F345	7.5	Yes	Yes	0	9	8
139	A:A:F273	A:A:I348	2.51	Yes	No	0	9	4
140	A:A:F273	A:A:S349	2.64	Yes	Yes	5	9	7
141	A:A:C359	A:A:F273	2.79	Yes	Yes	5	5	9
142	A:A:I348	A:A:K274	8.72	No	No	0	4	5
143	A:A:V287	A:A:W277	3.68	No	Yes	5	6	6
144	A:A:S349	A:A:W277	3.71	Yes	Yes	5	7	6
145	A:A:H357	A:A:W277	24.33	No	Yes	0	7	6
146	A:A:C359	A:A:W277	3.92	Yes	Yes	5	5	6
147	A:A:N279	A:A:R280	4.82	No	No	0	8	5
148	A:A:L282	A:A:N279	6.87	No	No	0	9	8
149	A:A:R280	A:A:W281	14.99	No	Yes	0	5	5
150	A:A:W281	B:B:D290	8.93	Yes	No	1	5	6
151	A:A:W281	B:B:R314	13.99	Yes	Yes	1	5	8
152	A:A:I285	A:A:L282	2.85	No	No	0	7	9
153	A:A:R356	A:A:T284	7.76	No	No	0	2	4
154	A:A:S286	A:A:Y360	2.54	No	Yes	18	8	8
155	A:A:I382	A:A:S286	9.29	Yes	No	18	6	8
156	A:A:F290	A:A:I288	2.51	Yes	Yes	0	9	9
157	A:A:D378	A:A:I288	11.2	No	Yes	0	7	9
158	A:A:I288	A:A:I382	2.94	Yes	Yes	0	9	6
159	A:A:L289	A:A:L291	4.15	No	Yes	0	9	8
160	A:A:F345	A:A:L289	6.09	Yes	No	0	8	9
161	A:A:C359	A:A:L289	3.17	Yes	No	0	5	9
162	A:A:F290	A:A:H362	5.66	Yes	No	0	9	9
163	A:A:F290	A:A:T364	5.19	Yes	Yes	11	9	9
164	A:A:L291	A:A:Q294	5.32	Yes	Yes	5	8	6
165	A:A:F363	A:A:L291	4.87	Yes	Yes	5	5	8
166	A:A:N292	A:A:T364	4.39	Yes	Yes	11	9	9
167	A:A:K293	A:A:L296	4.23	No	No	0	9	6
168	A:A:K338	A:A:Q294	6.78	No	Yes	5	5	6
169	A:A:F363	A:A:Q294	10.54	Yes	Yes	5	5	6
170	A:A:R333	A:A:V301	2.62	No	No	0	5	7
171	A:A:V301	A:A:V334	3.21	No	Yes	0	7	4
172	A:A:F312	A:A:F340	6.43	No	Yes	0	8	7
173	A:A:E314	A:A:E344	2.54	No	Yes	0	6	5
174	A:A:F315	A:A:F340	12.86	No	Yes	0	6	7
175	A:A:P321	A:A:Y318	5.56	No	No	0	5	6
176	A:A:F340	A:A:Y318	10.32	Yes	No	0	7	6
177	A:A:D343	A:A:Y318	11.49	No	No	0	3	6
178	A:A:P321	A:A:T320	3.5	No	No	0	5	1
179	A:A:R336	A:A:T320	9.06	No	No	0	5	1
180	A:A:P321	A:A:Y339	4.17	No	Yes	0	5	3
181	A:A:D331	A:A:P332	8.05	No	No	0	4	1
182	A:A:K338	A:A:V334	3.04	No	Yes	0	5	4
183	A:A:T335	A:A:Y339	2.5	No	Yes	0	4	3
184	A:A:F363	A:A:K338	7.44	Yes	No	5	5	5
185	A:A:R342	A:A:Y339	8.23	Yes	Yes	5	4	3
186	A:A:F363	A:A:Y339	4.13	Yes	Yes	5	5	3
187	A:A:E344	A:A:F340	7	Yes	Yes	0	5	7
188	A:A:F345	A:A:I341	2.51	Yes	No	0	8	8
189	A:A:L346	A:A:R342	7.29	No	Yes	5	4	4
190	A:A:P361	A:A:R342	5.76	No	Yes	5	5	4
191	A:A:F363	A:A:R342	7.48	Yes	Yes	5	5	4
192	A:A:E344	A:A:R347	6.98	Yes	No	0	5	4
193	A:A:L346	A:A:S349	6.01	No	Yes	5	4	7
194	A:A:L346	A:A:P361	6.57	No	No	5	4	5
195	A:A:S349	A:A:T350	4.8	Yes	No	0	7	4
196	A:A:C359	A:A:S349	3.44	Yes	Yes	5	5	7
197	A:A:D354	A:A:G355	5.03	No	No	0	3	2
198	A:A:H357	A:A:R356	3.39	No	No	0	7	2
199	A:A:Y358	A:A:Y360	2.98	No	Yes	0	4	8
200	A:A:C359	A:A:P361	3.77	Yes	No	5	5	5
201	A:A:D378	A:A:Y360	9.2	No	Yes	0	7	8
202	A:A:D381	A:A:Y360	5.75	No	Yes	0	8	8
203	A:A:I382	A:A:Y360	8.46	Yes	Yes	18	6	8
204	A:A:H362	A:A:R374	10.16	No	No	0	9	4
205	A:A:D378	A:A:H362	10.08	No	No	0	7	9
206	A:A:D368	A:A:T364	8.67	No	Yes	11	9	9
207	A:A:N371	A:A:T364	7.31	No	Yes	11	9	9
208	A:A:R374	A:A:T364	2.59	No	Yes	0	4	9
209	A:A:D368	A:A:N371	9.42	No	No	11	9	9
210	A:A:F376	A:A:R373	4.28	Yes	Yes	7	8	5
211	A:A:F376	A:A:N377	6.04	Yes	No	0	8	4
212	A:A:F376	A:A:K380	6.2	Yes	No	7	8	7
213	A:A:F376	R:R:F690	7.5	Yes	Yes	7	8	8
214	A:A:K380	R:R:V689	3.04	No	No	7	7	9
215	A:A:K380	R:R:F690	6.2	No	Yes	7	7	8
216	A:A:D381	A:A:Q385	3.92	No	No	0	8	5
217	A:A:I382	A:A:M386	2.92	Yes	No	0	6	4
218	A:A:I383	A:A:N387	2.83	Yes	No	0	8	8
219	A:A:I383	R:R:V689	3.07	Yes	No	7	8	9
220	A:A:I383	R:R:F690	3.77	Yes	Yes	7	8	8
221	A:A:L384	A:A:L388	2.77	No	Yes	0	6	8
222	A:A:N387	R:R:R685	9.64	No	No	0	8	8
223	A:A:L388	A:A:L393	2.77	Yes	Yes	0	8	8
224	A:A:L388	A:A:V394	2.98	Yes	No	0	8	8
225	A:A:L388	R:R:I686	2.85	Yes	Yes	0	8	7
226	A:A:R389	A:A:V394	14.38	No	No	0	5	8
227	A:A:E390	R:R:S620	4.31	No	No	0	4	8
228	A:A:Y391	R:R:T619	2.5	Yes	Yes	0	4	8
229	A:A:Y391	R:R:R623	10.29	Yes	No	0	4	9
230	A:A:Y391	R:R:L678	4.69	Yes	Yes	0	4	8
231	A:A:Y391	R:R:L681	4.69	Yes	Yes	0	4	7
232	A:A:Y391	R:R:L682	10.55	Yes	No	0	4	9
233	A:A:N392	R:R:D842	10.77	No	No	0	7	9
234	A:A:L393	R:R:S792	3	Yes	No	0	8	8
235	A:A:L393	R:R:L796	8.3	Yes	No	19	8	9
236	B:B:Q44	B:B:R42	7.01	No	No	0	4	2
237	B:B:I43	B:B:M45	5.83	No	Yes	0	3	4
238	B:B:Q44	B:B:R46	3.5	No	No	0	4	5
239	B:B:M45	B:B:V296	3.04	Yes	Yes	3	4	5
240	B:B:L308	B:B:M45	9.9	Yes	Yes	3	7	4
241	B:B:M45	G:G:L50	5.65	Yes	No	0	4	9
242	B:B:K337	B:B:T47	4.5	Yes	No	3	6	3
243	B:B:T47	B:B:W339	7.28	No	Yes	3	3	9
244	B:B:R48	B:B:R49	3.2	Yes	No	13	7	7
245	B:B:A326	B:B:R48	4.15	No	Yes	13	7	7
246	B:B:I338	B:B:R48	6.26	No	Yes	13	5	7
247	B:B:N340	B:B:R48	4.82	No	Yes	13	9	7
248	B:B:R49	B:B:T87	3.88	No	No	0	7	5
249	B:B:I338	B:B:R49	2.51	No	No	13	5	7
250	B:B:R52	B:B:T50	2.59	No	No	3	7	3
251	B:B:F335	B:B:T50	2.59	No	No	3	4	3
252	B:B:K337	B:B:T50	4.5	Yes	No	3	6	3
253	B:B:L51	B:B:W82	15.94	Yes	Yes	0	9	9
254	B:B:L51	B:B:T87	2.95	Yes	No	0	9	5
255	B:B:L336	B:B:L51	5.54	Yes	Yes	0	7	9
256	B:B:I338	B:B:L51	4.28	No	Yes	0	5	9
257	B:B:F335	B:B:R52	22.45	No	No	3	4	7
258	B:B:G53	B:B:W82	2.81	No	Yes	0	9	9
259	B:B:H54	B:B:I58	7.95	Yes	No	1	9	9
260	B:B:H54	B:B:S72	4.18	Yes	Yes	1	9	9
261	B:B:H54	B:B:S74	12.55	Yes	No	0	9	9
262	B:B:H54	B:B:I80	9.28	Yes	Yes	1	9	8
263	B:B:H54	B:B:W82	7.41	Yes	Yes	1	9	9
264	B:B:H54	B:B:S334	4.18	Yes	No	0	9	4
265	B:B:H54	B:B:L336	3.86	Yes	Yes	1	9	7
266	B:B:D76	B:B:L55	10.86	Yes	Yes	1	9	6
267	B:B:K57	B:B:Y59	11.94	Yes	Yes	1	9	8
268	B:B:K57	B:B:Q75	6.78	Yes	Yes	1	9	9
269	B:B:K57	B:B:W332	8.12	Yes	Yes	1	9	9
270	B:B:G330	B:B:I58	3.53	No	No	0	5	9
271	B:B:I58	B:B:L336	7.14	No	Yes	1	9	7
272	B:B:Q75	B:B:Y59	10.15	Yes	Yes	1	9	8
273	B:B:W332	B:B:Y59	3.86	Yes	Yes	1	9	8
274	B:B:L70	B:B:M61	5.65	No	No	0	5	6
275	B:B:M61	B:B:S72	3.07	No	Yes	0	6	9
276	B:B:C317	B:B:M61	6.48	No	No	0	7	6
277	B:B:H62	B:B:R150	4.51	No	Yes	0	6	6
278	B:B:L70	B:B:W63	9.11	No	Yes	21	5	7
279	B:B:S84	B:B:W63	6.18	No	Yes	21	5	7
280	B:B:T321	B:B:W63	10.92	No	Yes	0	7	7
281	B:B:A328	B:B:W63	5.19	No	Yes	0	5	7
282	B:B:I81	B:B:L69	4.28	Yes	No	9	7	5
283	B:B:L69	B:B:Y105	3.52	No	Yes	9	5	6
284	B:B:L70	B:B:S84	3	No	No	21	5	5
285	B:B:L79	B:B:V71	2.98	Yes	No	9	7	8
286	B:B:V71	B:B:Y105	7.57	No	Yes	9	8	6
287	B:B:V112	B:B:V71	3.21	No	No	9	8	8
288	B:B:S72	B:B:W82	4.94	Yes	Yes	1	9	9
289	B:B:L336	B:B:S72	9.01	Yes	Yes	1	7	9
290	B:B:A73	B:B:V100	3.39	No	No	0	9	9
291	B:B:A73	B:B:C103	3.61	No	No	0	9	8
292	B:B:D76	B:B:S74	4.42	Yes	No	0	9	9
293	B:B:Q75	B:B:W99	9.86	Yes	Yes	1	9	9
294	B:B:D76	B:B:G77	3.35	Yes	No	0	9	8
295	B:B:D76	B:B:K78	8.3	Yes	No	1	9	8
296	B:B:I80	B:B:K78	2.91	Yes	No	1	8	8
297	B:B:L79	B:B:L95	5.54	Yes	Yes	9	7	8
298	B:B:L79	B:B:V112	2.98	Yes	No	9	7	8
299	B:B:C114	B:B:L79	3.17	No	Yes	9	8	7
300	B:B:I80	B:B:W82	9.4	Yes	Yes	1	8	9
301	B:B:I80	B:B:K89	2.91	Yes	Yes	1	8	9
302	B:B:H91	B:B:I81	11.93	No	Yes	0	5	7
303	B:B:I81	B:B:I93	2.94	Yes	No	0	7	7
304	B:B:I81	B:B:Y105	4.84	Yes	Yes	9	7	6
305	B:B:I81	B:B:L126	4.28	Yes	No	0	7	5
306	B:B:K89	B:B:W82	13.92	Yes	Yes	1	9	9
307	B:B:D83	B:B:T86	10.12	No	No	0	8	6
308	B:B:D83	B:B:V90	4.38	No	No	0	8	5
309	B:B:S84	B:B:Y85	2.54	No	No	0	5	4
310	B:B:H91	B:B:V90	5.54	No	No	0	5	5
311	B:B:I93	B:B:P94	3.39	No	No	0	7	5
312	B:B:I93	B:B:V133	3.07	No	No	0	7	4
313	B:B:L95	B:B:V100	2.98	Yes	No	9	8	9
314	B:B:C114	B:B:L95	4.76	No	Yes	9	8	8
315	B:B:L95	B:B:Y124	8.21	Yes	No	0	8	6
316	B:B:I120	B:B:R96	2.51	Yes	No	22	6	6
317	B:B:E138	B:B:R96	11.63	Yes	No	22	6	6
318	B:B:D118	B:B:S97	8.83	No	No	0	9	8
319	B:B:L117	B:B:W99	3.42	Yes	Yes	1	9	9
320	B:B:C114	B:B:V100	3.42	No	No	9	8	9
321	B:B:G116	B:B:M101	3.49	No	Yes	0	9	9
322	B:B:L117	B:B:M101	2.83	Yes	Yes	1	9	9
323	B:B:M101	B:B:Y145	4.79	Yes	Yes	1	9	8
324	B:B:C149	B:B:T102	5.07	No	No	0	8	8
325	B:B:A104	B:B:F151	2.77	No	Yes	0	7	9
326	B:B:G109	B:B:Y105	2.9	No	Yes	0	5	6
327	B:B:A106	B:B:F151	6.93	No	Yes	0	6	9
328	B:B:N110	B:B:S108	4.47	No	No	23	4	6
329	B:B:D154	B:B:S108	8.83	No	No	23	6	6
330	B:B:D154	B:B:N110	4.04	No	No	23	6	4
331	B:B:I123	B:B:Y111	6.04	Yes	Yes	0	6	4
332	B:B:N125	B:B:Y111	5.81	No	Yes	0	4	4
333	B:B:S136	B:B:Y111	5.09	No	Yes	0	4	4
334	B:B:D154	B:B:Y111	9.2	No	Yes	0	6	4
335	B:B:L126	B:B:V112	5.96	No	No	0	5	8
336	B:B:A113	B:B:F151	2.77	No	Yes	0	9	9
337	B:B:L117	B:B:Y145	3.52	Yes	Yes	1	9	8
338	B:B:D118	B:B:I120	5.6	No	Yes	0	9	6
339	B:B:G144	B:B:N119	3.39	No	No	1	8	9
340	B:B:E138	B:B:I120	6.83	Yes	Yes	22	6	6
341	B:B:A140	B:B:I120	3.25	No	Yes	0	5	6
342	B:B:C121	B:B:L139	4.76	No	No	0	8	9
343	B:B:C121	B:B:L146	3.17	No	No	10	8	7
344	B:B:C121	B:B:T159	3.38	No	Yes	10	8	9
345	B:B:S122	B:B:Y124	6.36	No	No	0	8	6
346	B:B:E138	B:B:S122	4.31	Yes	No	0	6	8
347	B:B:F151	B:B:I123	5.02	Yes	Yes	15	9	6
348	B:B:I123	B:B:I171	4.42	Yes	No	15	6	6
349	B:B:V135	B:B:Y124	3.79	No	No	0	4	6
350	B:B:K127	B:B:N125	6.99	No	No	0	4	4
351	B:B:E138	B:B:V135	2.85	Yes	No	0	6	4
352	B:B:L139	B:B:W169	13.67	No	Yes	0	9	8
353	B:B:G141	B:B:W169	2.81	No	Yes	0	5	8
354	B:B:H142	B:B:L146	5.14	Yes	No	10	9	7
355	B:B:H142	B:B:T159	6.85	Yes	Yes	10	9	9
356	B:B:H142	B:B:S161	16.74	Yes	No	0	9	9
357	B:B:H142	B:B:T165	2.74	Yes	No	0	9	7
358	B:B:A167	B:B:H142	4.39	No	Yes	10	4	9
359	B:B:D163	B:B:T143	13.01	No	No	0	9	5
360	B:B:S147	B:B:Y145	10.17	No	Yes	0	9	8
361	B:B:G162	B:B:Y145	2.9	No	Yes	1	9	8
362	B:B:D186	B:B:Y145	11.49	Yes	Yes	1	9	8
363	B:B:M188	B:B:Y145	3.59	Yes	Yes	1	8	8
364	B:B:L146	B:B:T159	4.42	No	Yes	10	7	9
365	B:B:C148	B:B:R150	6.96	No	Yes	0	6	6
366	B:B:C149	B:B:I157	3.27	No	No	0	8	7
367	B:B:F151	B:B:I157	12.56	Yes	No	0	9	7
368	B:B:F151	B:B:I171	2.51	Yes	No	15	9	6
369	B:B:L152	B:B:V158	4.47	Yes	No	0	3	5
370	B:B:L152	B:B:L192	5.54	Yes	No	0	3	5
371	B:B:L152	B:B:T196	4.42	Yes	No	0	3	1
372	B:B:L152	B:B:V213	2.98	Yes	No	0	3	4
373	B:B:D153	B:B:N155	12.12	No	No	0	5	3
374	B:B:D153	B:B:Q156	10.44	No	No	0	5	5
375	B:B:L168	B:B:Q156	6.65	Yes	No	0	6	5
376	B:B:L168	B:B:V158	4.47	Yes	No	0	6	5
377	B:B:L190	B:B:V158	2.98	Yes	No	0	5	5
378	B:B:T159	B:B:W169	7.28	Yes	Yes	10	9	8
379	B:B:S160	B:B:V187	4.85	No	No	0	6	9
380	B:B:L190	B:B:S160	6.01	Yes	No	0	5	6
381	B:B:G162	B:B:S161	3.71	No	No	0	9	9
382	B:B:D163	B:B:S161	2.94	No	No	0	9	9
383	B:B:D186	B:B:G162	5.03	Yes	No	1	9	9
384	B:B:D163	B:B:T165	7.23	No	No	0	9	7
385	B:B:T165	B:B:T181	3.14	No	No	0	7	2
386	B:B:C166	B:B:F180	2.79	Yes	Yes	8	8	7
387	B:B:C166	B:B:V187	5.12	Yes	No	8	8	9
388	B:B:C166	B:B:F199	5.59	Yes	Yes	8	8	9
389	B:B:C166	B:B:S201	3.44	Yes	Yes	8	8	9
390	B:B:A167	B:B:W169	2.59	No	Yes	10	4	8
391	B:B:A167	B:B:Q176	4.55	No	No	10	4	4
392	B:B:L168	B:B:T178	4.42	Yes	No	8	6	4
393	B:B:F180	B:B:L168	4.87	Yes	Yes	8	7	6
394	B:B:G174	B:B:W169	2.81	No	Yes	0	4	8
395	B:B:Q176	B:B:W169	14.24	No	Yes	10	4	8
396	B:B:D170	B:B:T173	5.78	Yes	No	24	9	5
397	B:B:D170	B:B:Q175	2.61	Yes	No	24	9	4
398	B:B:D170	B:B:T177	4.34	Yes	No	0	9	4
399	B:B:Q175	B:B:T173	8.5	No	No	24	4	5
400	B:B:Q176	B:B:T179	9.92	No	No	0	4	4
401	B:B:F180	B:B:T178	9.08	Yes	No	8	7	4
402	B:B:F180	B:B:F199	10.72	Yes	Yes	8	7	9
403	B:B:F180	B:B:W211	12.03	Yes	Yes	8	7	8
404	B:B:F180	B:B:G216	3.01	Yes	No	0	7	4
405	B:B:G182	B:B:T181	3.64	No	No	0	6	2
406	B:B:G182	G:G:K14	3.49	No	No	0	6	4
407	B:B:H183	B:B:S201	2.79	Yes	Yes	0	9	9
408	B:B:A203	B:B:H183	8.78	No	Yes	0	8	9
409	B:B:H183	B:B:S207	5.58	Yes	No	0	9	5
410	B:B:H183	B:B:K209	17.03	Yes	Yes	0	9	6
411	B:B:D205	B:B:T184	5.78	No	No	0	9	3
412	B:B:D205	B:B:G185	5.03	No	No	0	9	5
413	B:B:D186	B:B:M188	5.54	Yes	Yes	1	9	8
414	B:B:C204	B:B:D186	4.67	Yes	Yes	1	7	9
415	B:B:S201	B:B:V187	4.85	Yes	No	8	9	9
416	B:B:C204	B:B:M188	4.86	Yes	Yes	1	7	8
417	B:B:M188	B:B:N230	2.8	Yes	No	0	8	9
418	B:B:I232	B:B:S189	3.1	Yes	No	0	8	7
419	B:B:F199	B:B:L190	6.09	Yes	Yes	0	9	5
420	B:B:I232	B:B:S191	4.64	Yes	No	0	8	8
421	B:B:F234	B:B:S191	3.96	Yes	No	0	5	8
422	B:B:A193	B:B:F234	4.16	No	Yes	0	4	5
423	B:B:F234	B:B:P194	2.89	Yes	No	2	5	4
424	B:B:G238	B:B:P194	4.06	No	No	2	7	4
425	B:B:D195	B:B:R197	8.34	No	No	25	5	5
426	B:B:D195	B:B:L198	2.71	No	Yes	25	5	3
427	B:B:L198	B:B:R197	3.64	Yes	No	25	3	5
428	B:B:L198	B:B:L210	2.77	Yes	Yes	0	3	5
429	B:B:L198	B:B:R219	4.86	Yes	No	0	3	5
430	B:B:F199	B:B:W211	10.02	Yes	Yes	8	9	8
431	B:B:F199	B:B:V213	2.62	Yes	No	0	9	4
432	B:B:L210	B:B:V200	4.47	Yes	Yes	0	5	6
433	B:B:I232	B:B:V200	4.61	Yes	Yes	2	8	6
434	B:B:F234	B:B:V200	10.49	Yes	Yes	2	5	6
435	B:B:F241	B:B:V200	6.55	Yes	Yes	2	6	6
436	B:B:S201	B:B:W211	7.41	Yes	Yes	8	9	8
437	B:B:G202	B:B:I229	3.53	No	Yes	2	6	7
438	B:B:G202	B:B:I232	3.53	No	Yes	2	6	8
439	B:B:C204	B:B:D228	7.78	Yes	Yes	1	7	9
440	B:B:D205	B:B:S207	4.42	No	No	0	9	5
441	B:B:A208	B:B:F241	2.77	No	Yes	0	6	6
442	B:B:K209	B:B:W211	15.08	Yes	Yes	8	6	8
443	B:B:C218	B:B:K209	6.47	No	Yes	8	5	6
444	B:B:K209	B:B:T221	9.01	Yes	No	0	6	7
445	B:B:K209	G:G:Q18	4.07	Yes	Yes	8	6	9
446	B:B:L210	B:B:Q220	7.99	Yes	Yes	0	5	7
447	B:B:L210	B:B:L255	9.69	Yes	No	0	5	6
448	B:B:C218	B:B:W211	2.61	No	Yes	8	5	8
449	B:B:D212	B:B:E215	9.09	No	No	0	9	3
450	B:B:D212	B:B:R219	7.15	No	No	0	9	5
451	B:B:E215	B:B:R214	9.3	No	No	0	3	9
452	B:B:C218	G:G:Q18	9.16	No	Yes	8	5	9
453	B:B:F222	B:B:Q220	3.51	Yes	Yes	2	8	7
454	B:B:D258	B:B:Q220	13.05	No	Yes	2	7	7
455	B:B:Q220	G:G:I25	4.12	Yes	No	0	7	2
456	B:B:T221	G:G:E22	2.82	No	No	0	7	9
457	B:B:F222	B:B:F241	7.5	Yes	Yes	2	8	6
458	B:B:F222	B:B:F253	10.72	Yes	Yes	2	8	6
459	B:B:F222	B:B:L255	3.65	Yes	No	0	8	6
460	B:B:D258	B:B:F222	5.97	No	Yes	2	7	8
461	B:B:E260	B:B:G224	4.91	Yes	No	0	6	6
462	B:B:H225	B:B:I229	7.95	Yes	Yes	2	9	7
463	B:B:H225	B:B:T243	8.21	Yes	Yes	2	9	8
464	B:B:H225	B:B:S245	11.16	Yes	No	2	9	9
465	B:B:D247	B:B:H225	3.78	Yes	Yes	2	9	9
466	B:B:H225	B:B:R251	14.67	Yes	Yes	2	9	8
467	B:B:F253	B:B:H225	4.53	Yes	Yes	2	6	9
468	B:B:D247	B:B:E226	6.5	Yes	No	0	9	3
469	B:B:E226	B:B:R251	3.49	No	Yes	0	3	8
470	B:B:D228	B:B:S227	2.94	Yes	No	1	9	6
471	B:B:D246	B:B:S227	4.42	No	No	1	9	6
472	B:B:D228	B:B:D246	2.66	Yes	No	1	9	9
473	B:B:I229	B:B:I232	2.94	Yes	Yes	2	7	8
474	B:B:I229	B:B:T243	3.04	Yes	Yes	2	7	8
475	B:B:A231	B:B:V276	3.39	No	No	0	5	6
476	B:B:F241	B:B:I232	6.28	Yes	Yes	2	6	8
477	B:B:I232	B:B:T243	7.6	Yes	Yes	2	8	8
478	B:B:F234	B:B:G238	3.01	Yes	No	2	5	7
479	B:B:F235	B:B:P236	10.11	Yes	Yes	2	6	7
480	B:B:F235	B:B:N237	12.08	Yes	Yes	2	6	5
481	B:B:F235	B:B:F278	6.43	Yes	Yes	2	6	7
482	B:B:F235	G:G:L37	4.87	Yes	No	0	6	7
483	B:B:F235	G:G:Y40	4.13	Yes	Yes	2	6	6
484	B:B:F278	B:B:P236	2.89	Yes	Yes	2	7	7
485	B:B:G282	B:B:P236	4.06	No	Yes	2	9	7
486	B:B:P236	G:G:Y40	6.95	Yes	Yes	2	7	6
487	B:B:G238	B:B:N237	3.39	No	Yes	2	7	5
488	B:B:N237	B:B:N239	6.81	Yes	No	0	5	2
489	B:B:N237	G:G:Y40	8.14	Yes	Yes	2	5	6
490	B:B:N239	B:B:R256	3.62	No	Yes	0	2	9
491	B:B:F241	B:B:T243	3.89	Yes	Yes	2	6	8
492	B:B:F241	B:B:F253	6.43	Yes	Yes	2	6	6
493	B:B:A242	B:B:L252	3.15	No	No	0	4	7
494	B:B:A242	B:B:F278	2.77	No	Yes	0	4	7
495	B:B:F253	B:B:T243	7.78	Yes	Yes	2	6	8
496	B:B:G244	B:B:I273	5.29	No	No	0	5	6
497	B:B:D247	B:B:S245	10.31	Yes	No	2	9	9
498	B:B:D247	B:B:T249	10.12	Yes	Yes	2	9	6
499	B:B:R251	B:B:T249	3.88	Yes	Yes	2	8	6
500	B:B:T249	B:B:T263	3.14	Yes	No	2	6	1
501	B:B:S265	B:B:T249	6.4	No	Yes	0	2	6
502	B:B:C250	B:B:Y264	4.03	No	Yes	2	8	5
503	B:B:C250	B:B:I273	6.55	No	No	0	8	6
504	B:B:C250	B:B:L285	3.17	No	No	2	8	6
505	B:B:E260	B:B:R251	18.61	Yes	Yes	0	6	8
506	B:B:R251	B:B:T263	14.23	Yes	No	2	8	1
507	B:B:L252	B:B:Y264	3.52	No	Yes	0	7	5
508	B:B:E260	B:B:F253	18.66	Yes	Yes	0	6	6
509	B:B:D254	B:B:R256	8.34	Yes	Yes	26	9	9
510	B:B:A257	B:B:D254	4.63	No	Yes	0	7	9
511	B:B:D254	B:B:L261	5.43	Yes	No	0	9	5
512	B:B:D254	G:G:A33	3.09	Yes	No	26	9	7
513	B:B:R256	G:G:I28	12.53	Yes	No	0	9	4
514	B:B:R256	G:G:A33	2.77	Yes	No	26	9	7
515	B:B:R256	G:G:D36	3.57	Yes	No	0	9	5
516	B:B:M262	B:B:Y264	3.59	No	Yes	0	4	5
517	B:B:L285	B:B:Y264	4.69	No	Yes	2	6	5
518	B:B:W297	B:B:Y264	14.47	Yes	Yes	2	8	5
519	B:B:A302	B:B:Y264	2.67	No	Yes	0	2	5
520	B:B:D267	B:B:H266	6.3	No	No	27	3	4
521	B:B:H266	B:B:N268	11.48	No	No	27	4	4
522	B:B:D267	B:B:N268	8.08	No	No	27	3	4
523	B:B:I269	B:B:Y289	3.63	No	Yes	0	4	7
524	B:B:C271	B:B:D291	3.11	No	No	0	5	8
525	B:B:I273	B:B:Y289	10.88	No	Yes	0	6	7
526	B:B:S275	B:B:T274	3.2	No	No	0	8	8
527	B:B:R314	B:B:T274	7.76	Yes	No	0	8	8
528	B:B:F278	B:B:G282	3.01	Yes	No	2	7	9
529	B:B:F278	B:B:L285	3.65	Yes	No	2	7	6
530	B:B:L284	B:B:S279	4.5	No	No	0	5	9
531	B:B:S279	G:G:D48	4.42	No	No	0	9	9
532	B:B:S279	G:G:L50	3	No	No	0	9	9
533	B:B:S281	G:G:D48	10.31	No	No	0	9	9
534	B:B:D298	B:B:R283	10.72	No	Yes	0	9	9
535	B:B:L300	B:B:R283	3.64	No	Yes	28	6	9
536	B:B:R283	G:G:C41	5.57	Yes	No	28	9	7
537	B:B:L284	B:B:V296	2.98	No	Yes	0	5	5
538	B:B:L286	B:B:V296	4.47	No	Yes	0	7	5
539	B:B:L286	B:B:V327	4.47	No	Yes	0	7	6
540	B:B:A287	B:B:Y289	2.67	No	Yes	2	6	7
541	B:B:A287	B:B:W297	2.59	No	Yes	2	6	8
542	B:B:C294	B:B:G288	3.92	Yes	No	3	5	7
543	B:B:G288	B:B:L318	3.42	No	No	3	7	6
544	B:B:N293	B:B:Y289	5.81	No	Yes	2	5	7
545	B:B:N295	B:B:Y289	5.81	No	Yes	2	6	7
546	B:B:W297	B:B:Y289	8.68	Yes	Yes	2	8	7
547	B:B:D290	B:B:R314	8.34	No	Yes	1	6	8
548	B:B:D291	B:B:N293	2.69	No	No	0	8	5
549	B:B:N293	B:B:N295	6.81	No	No	2	5	6
550	B:B:C294	B:B:L308	6.35	Yes	Yes	3	5	7
551	B:B:C294	B:B:V315	3.42	Yes	No	3	5	7
552	B:B:C294	B:B:L318	3.17	Yes	No	3	5	6
553	B:B:N295	B:B:R304	10.85	No	No	0	6	5
554	B:B:L308	B:B:V296	2.98	Yes	Yes	3	7	5
555	B:B:R304	B:B:W297	9	No	Yes	0	5	8
556	B:B:D298	B:B:K301	9.68	No	No	0	9	5
557	B:B:L300	G:G:M38	2.83	No	No	0	6	4
558	B:B:L300	G:G:C41	3.17	No	No	28	6	7
559	B:B:R304	B:B:V307	2.62	No	No	0	5	3
560	B:B:L308	B:B:W339	3.42	Yes	Yes	3	7	9
561	B:B:H311	B:B:V315	2.77	Yes	No	3	9	7
562	B:B:H311	B:B:T329	5.48	Yes	Yes	3	9	8
563	B:B:H311	B:B:S331	13.95	Yes	No	0	9	9
564	B:B:H311	B:B:K337	7.86	Yes	Yes	3	9	6
565	B:B:D312	B:B:D333	7.98	No	No	0	5	9
566	B:B:N313	B:B:W332	4.52	No	Yes	0	7	9
567	B:B:D333	B:B:N313	6.73	No	No	0	9	7
568	B:B:R314	B:B:W332	6	Yes	Yes	1	8	9
569	B:B:T329	B:B:V315	3.17	Yes	No	3	8	7
570	B:B:S316	B:B:W332	4.94	No	Yes	0	9	9
571	B:B:L318	B:B:T329	5.9	No	Yes	3	6	8
572	B:B:V320	B:B:V327	6.41	No	Yes	0	7	6
573	B:B:D323	B:B:T321	7.23	No	No	0	7	7
574	B:B:G324	B:B:T321	3.64	No	No	0	9	7
575	B:B:D323	B:B:M325	5.54	No	No	0	7	5
576	B:B:M325	G:G:P49	6.71	No	No	0	5	7
577	B:B:A326	B:B:N340	4.69	No	No	13	7	9
578	B:B:V327	B:B:W339	3.68	Yes	Yes	0	6	9
579	B:B:V327	G:G:L50	4.47	Yes	No	0	6	9
580	B:B:T329	B:B:W339	8.49	Yes	Yes	3	8	9
581	B:B:K337	B:B:W339	6.96	Yes	Yes	3	6	9
582	G:G:E17	G:G:R13	6.98	No	No	0	6	6
583	G:G:E17	G:G:K14	4.05	No	No	0	6	4
584	G:G:M21	G:G:Q18	6.8	No	Yes	0	1	9
585	G:G:E22	G:G:Q18	5.1	No	Yes	0	9	9
586	G:G:E22	G:G:L19	5.3	No	No	0	9	9
587	G:G:I28	G:G:K32	4.36	No	No	0	4	5
588	G:G:D36	G:G:L37	5.43	No	No	0	5	7
589	G:G:E42	G:G:M38	4.06	No	No	0	1	4
590	G:G:H44	G:G:Y40	21.78	No	Yes	0	6	6
591	G:G:A43	G:G:H44	2.93	No	No	0	4	6
592	G:G:E47	G:G:H44	4.92	No	No	0	3	6
593	G:G:D48	G:G:P49	3.22	No	No	0	9	7
594	R:R:S568	R:R:V577	3.23	No	No	0	9	3
595	R:R:S568	R:R:V585	3.23	No	No	0	9	8
596	R:R:F569	R:R:T589	7.78	Yes	No	6	9	9
597	R:R:F569	R:R:L593	6.09	Yes	Yes	6	9	8
598	R:R:F569	R:R:Y668	3.09	Yes	Yes	6	9	8
599	R:R:F569	R:R:W804	3.01	Yes	Yes	6	9	9
600	R:R:F569	R:R:F823	3.22	Yes	Yes	6	9	9
601	R:R:F569	R:R:N827	3.62	Yes	Yes	6	9	9
602	R:R:S570	R:R:T810	3.2	No	Yes	6	9	7
603	R:R:H820	R:R:S570	13.95	Yes	No	6	8	9
604	R:R:I571	R:R:V577	4.61	No	No	0	7	3
605	R:R:F641	R:R:I571	5.02	Yes	No	0	9	7
606	R:R:F641	R:R:L572	3.65	Yes	No	0	9	9
607	R:R:L572	R:R:Y668	8.21	No	Yes	0	9	8
608	R:R:G807	R:R:M573	5.24	No	No	6	9	9
609	R:R:M573	R:R:T810	4.52	No	Yes	6	9	7
610	R:R:F823	R:R:M573	4.98	Yes	No	6	9	9
611	R:R:P575	R:R:S574	3.56	No	Yes	0	6	9
612	R:R:S574	R:R:T810	4.8	Yes	Yes	0	9	7
613	R:R:I811	R:R:S574	4.64	No	Yes	0	5	9
614	R:R:S574	R:R:S814	3.26	Yes	No	0	9	5
615	R:R:P575	R:R:W737	12.16	No	Yes	0	6	6
616	R:R:F576	R:R:S814	9.25	No	No	0	3	5
617	R:R:P578	R:R:T580	3.5	No	No	0	4	3
618	R:R:H820	R:R:P578	6.1	Yes	No	0	8	4
619	R:R:I581	R:R:T580	4.56	Yes	No	29	4	3
620	R:R:L817	R:R:T580	11.79	No	No	29	2	3
621	R:R:I581	R:R:V584	3.07	Yes	No	0	4	3
622	R:R:I581	R:R:L817	4.28	Yes	No	29	4	2
623	R:R:F582	R:R:K586	9.93	No	No	0	1	3
624	R:R:K586	R:R:P583	6.69	No	No	0	3	1
625	R:R:I588	R:R:L825	8.56	No	No	0	9	5
626	R:R:L593	R:R:T589	2.95	Yes	No	6	8	9
627	R:R:F829	R:R:G592	6.02	Yes	No	0	7	9
628	R:R:D638	R:R:L593	4.07	Yes	Yes	0	7	8
629	R:R:I642	R:R:L593	4.28	No	Yes	0	8	8
630	R:R:F829	R:R:I595	3.77	Yes	No	0	7	7
631	R:R:G831	R:R:S596	3.71	No	No	0	9	9
632	R:R:I597	R:R:L635	4.28	Yes	No	0	7	8
633	R:R:D638	R:R:I597	2.8	Yes	Yes	0	7	7
634	R:R:I597	R:R:V639	3.07	Yes	No	0	7	6
635	R:R:G598	R:R:I601	3.53	No	No	0	3	5
636	R:R:F832	R:R:S599	2.64	Yes	No	0	5	8
637	R:R:L835	R:R:S599	9.01	No	No	0	8	8
638	R:R:L600	R:R:L634	5.54	No	Yes	0	9	9
639	R:R:L600	R:R:L635	2.77	No	No	0	9	8
640	R:R:G831	R:R:L600	5.13	No	No	0	9	9
641	R:R:I601	R:R:I605	2.94	No	No	0	5	6
642	R:R:I601	R:R:L635	2.85	No	No	0	5	8
643	R:R:L602	R:R:L835	4.15	No	No	0	6	8
644	R:R:C603	R:R:E607	6.08	No	No	0	7	9
645	R:R:L604	R:R:L632	6.92	No	No	0	8	5
646	R:R:I606	R:R:I839	2.94	No	No	0	8	7
647	R:R:E607	R:R:R624	5.82	No	Yes	0	9	9
648	R:R:E607	R:R:M627	6.77	No	No	0	9	7
649	R:R:F610	R:R:R624	6.41	No	Yes	0	8	9
650	R:R:H621	R:R:W611	3.17	No	No	0	6	9
651	R:R:Q618	R:R:T619	2.83	No	Yes	0	7	8
652	R:R:R685	R:R:T619	19.41	No	Yes	0	8	8
653	R:R:H621	R:R:I625	3.98	No	No	4	6	7
654	R:R:H621	R:R:M699	2.63	No	No	4	6	7
655	R:R:L681	R:R:T622	2.95	Yes	No	0	7	7
656	R:R:M698	R:R:T622	3.01	Yes	No	0	8	7
657	R:R:R623	R:R:R624	4.26	No	Yes	0	9	9
658	R:R:R624	R:R:V628	2.62	Yes	No	0	9	7
659	R:R:I625	R:R:M699	2.92	No	No	4	7	7
660	R:R:I625	W:W:?1	3.47	No	Yes	4	7	0
661	R:R:C626	R:R:W674	2.61	No	Yes	0	7	9
662	R:R:C626	R:R:L678	3.17	No	Yes	0	7	8
663	R:R:C626	W:W:?1	2.57	No	Yes	0	7	0
664	R:R:L799	R:R:M627	7.07	Yes	No	0	6	7
665	R:R:N629	R:R:V628	2.96	No	No	0	9	7
666	R:R:N629	R:R:W674	18.08	No	Yes	4	9	9
667	R:R:F703	R:R:N629	3.62	No	No	4	8	9
668	R:R:I630	R:R:L671	2.85	No	Yes	30	8	7
669	R:R:I630	R:R:M675	5.83	No	Yes	30	8	9
670	R:R:I630	R:R:L799	2.85	No	Yes	0	8	6
671	R:R:S633	R:R:S670	4.89	No	No	0	8	8
672	R:R:L671	R:R:S633	4.5	Yes	No	0	7	8
673	R:R:D638	R:R:L634	6.79	Yes	Yes	0	7	9
674	R:R:L634	R:R:L671	5.54	Yes	Yes	0	9	7
675	R:R:L634	R:R:Q830	5.32	Yes	No	0	9	9
676	R:R:F667	R:R:I636	18.84	No	No	0	8	7
677	R:R:A637	R:R:Y668	9.34	No	Yes	0	9	8
678	R:R:D638	R:R:Y668	3.45	Yes	Yes	0	7	8
679	R:R:V643	R:R:W640	3.68	No	No	0	8	6
680	R:R:A660	R:R:W640	3.89	No	No	0	7	6
681	R:R:F663	R:R:W640	18.04	No	No	0	8	6
682	R:R:F641	R:R:T664	2.59	Yes	No	0	9	7
683	R:R:C657	R:R:K728	3.23	No	No	0	9	5
684	R:R:C657	R:R:C733	7.28	No	No	0	9	9
685	R:R:V661	R:R:Y727	5.05	No	Yes	0	8	9
686	R:R:F662	R:R:F663	7.5	No	No	0	8	8
687	R:R:F662	R:R:S714	6.61	No	No	0	8	9
688	R:R:F663	R:R:F667	4.29	No	No	0	8	8
689	R:R:T664	R:R:Y668	2.5	No	Yes	0	7	8
690	R:R:T664	R:R:W734	3.64	No	No	0	7	8
691	R:R:H665	R:R:L669	5.14	Yes	Yes	12	9	9
692	R:R:H665	R:R:T717	2.74	Yes	No	0	9	9
693	R:R:H665	R:R:L735	3.86	Yes	Yes	0	9	9
694	R:R:F747	R:R:H665	7.92	No	Yes	12	8	9
695	R:R:F666	R:R:F667	6.43	Yes	No	0	7	8
696	R:R:F666	R:R:P710	2.89	Yes	Yes	0	7	9
697	R:R:F666	R:R:L711	8.53	Yes	No	0	7	7
698	R:R:F666	R:R:S714	3.96	Yes	No	0	7	9
699	R:R:W804	R:R:Y668	4.82	Yes	Yes	6	9	8
700	R:R:L669	R:R:P710	3.28	Yes	Yes	12	9	9
701	R:R:F747	R:R:L669	3.65	No	Yes	12	8	9
702	R:R:L669	R:R:P750	3.28	Yes	No	0	9	9
703	R:R:P710	R:R:S670	3.56	Yes	No	0	9	8
704	R:R:F672	R:R:L671	4.87	No	Yes	0	9	7
705	R:R:L671	R:R:M675	2.83	Yes	Yes	30	7	9
706	R:R:A751	R:R:F672	4.16	No	No	0	9	9
707	R:R:F672	R:R:W804	19.04	No	Yes	0	9	9
708	R:R:C709	R:R:F673	5.59	No	No	12	8	8
709	R:R:F673	R:R:P710	10.11	No	Yes	12	8	9
710	R:R:F673	R:R:I754	3.77	No	No	0	8	9
711	R:R:G702	R:R:W674	2.81	Yes	Yes	4	7	9
712	R:R:F703	R:R:W674	3.01	No	Yes	4	8	9
713	R:R:G706	R:R:W674	4.22	No	Yes	0	9	9
714	R:R:W674	R:R:Y707	7.72	Yes	No	4	9	9
715	R:R:M675	R:R:N758	4.21	Yes	No	0	9	9
716	R:R:G801	R:R:M675	3.49	No	Yes	0	9	9
717	R:R:I754	R:R:L676	4.28	No	No	0	9	7
718	R:R:G702	R:R:M677	5.24	Yes	No	4	7	6
719	R:R:L705	R:R:M677	5.65	No	No	0	6	6
720	R:R:M677	W:W:?1	9.16	No	Yes	4	6	0
721	R:R:L678	R:R:L799	4.15	Yes	Yes	0	8	6
722	R:R:I680	W:W:?1	15.03	No	Yes	0	8	0
723	R:R:L681	R:R:R685	6.07	Yes	No	0	7	8
724	R:R:L681	W:W:?1	8.97	Yes	Yes	0	7	0
725	R:R:I686	R:R:L682	2.85	Yes	No	20	7	9
726	R:R:L682	R:R:V765	4.47	No	No	20	9	9
727	R:R:A683	R:R:V761	3.39	No	No	0	6	8
728	R:R:L688	R:R:Y684	5.86	No	Yes	4	6	8
729	R:R:M693	R:R:Y684	9.58	No	Yes	4	5	8
730	R:R:M698	R:R:Y684	4.79	Yes	Yes	4	8	8
731	R:R:Y684	W:W:?1	2.85	Yes	Yes	4	8	0
732	R:R:I686	R:R:V765	4.61	Yes	No	20	7	9
733	R:R:I686	R:R:K768	2.91	Yes	No	0	7	8
734	R:R:I687	R:R:L764	7.14	No	No	0	6	7
735	R:R:L688	W:W:?1	3.36	No	Yes	4	6	0
736	R:R:F690	R:R:V689	2.62	Yes	No	7	8	9
737	R:R:M693	R:R:M698	2.89	No	Yes	4	5	8
738	R:R:H696	R:R:Q695	11.13	No	Yes	0	5	6
739	R:R:M699	R:R:Q695	4.08	No	Yes	0	7	6
740	R:R:L697	R:R:V701	2.98	No	No	0	3	6
741	R:R:M698	W:W:?1	9.16	Yes	Yes	4	8	0
742	R:R:G702	W:W:?1	2.77	Yes	Yes	4	7	0
743	R:R:F703	R:R:Y707	3.09	No	No	4	8	9
744	R:R:C709	R:R:P710	3.77	No	Yes	12	8	9
745	R:R:S714	R:R:V715	3.23	No	No	0	9	6
746	R:R:P743	R:R:T717	5.25	Yes	No	0	8	9
747	R:R:I718	R:R:Y727	13.3	No	Yes	0	7	9
748	R:R:Q722	R:R:T721	2.83	No	No	31	7	9
749	R:R:T721	R:R:Y727	6.24	No	Yes	31	9	9
750	R:R:Q722	R:R:Y727	5.64	No	Yes	31	7	9
751	R:R:R729	R:R:V732	5.23	No	No	0	5	4
752	R:R:N736	R:R:R729	7.23	No	No	0	8	5
753	R:R:D731	R:R:K730	5.53	No	No	0	3	2
754	R:R:L735	R:R:W734	13.67	Yes	No	0	9	8
755	R:R:F747	R:R:W734	9.02	No	No	0	8	8
756	R:R:L735	R:R:P743	6.57	Yes	Yes	0	9	8
757	R:R:L735	R:R:L744	4.15	Yes	No	0	9	8
758	R:R:N736	R:R:N739	12.26	No	No	0	8	4
759	R:R:G740	R:R:N736	5.09	No	No	0	4	8
760	R:R:S741	R:R:W737	6.18	No	Yes	0	8	6
761	R:R:L744	R:R:W737	6.83	No	Yes	0	8	6
762	R:R:L745	R:R:W737	3.42	No	Yes	0	8	6
763	R:R:I811	R:R:W737	3.52	No	Yes	0	5	6
764	R:R:G740	R:R:P743	6.09	No	Yes	0	4	8
765	R:R:K742	R:R:P743	3.35	No	Yes	0	7	8
766	R:R:L744	R:R:V748	2.98	No	No	0	8	7
767	R:R:L752	R:R:V748	4.47	No	No	0	8	7
768	R:R:I811	R:R:V748	3.07	No	No	0	5	7
769	R:R:P750	R:R:V749	5.3	No	No	0	9	7
770	R:R:I808	R:R:L752	5.71	No	No	0	7	8
771	R:R:I754	R:R:N758	4.25	No	No	0	9	9
772	R:R:G805	R:R:V755	3.68	No	No	0	6	8
773	R:R:L800	R:R:N758	8.24	Yes	No	0	9	9
774	R:R:L802	R:R:V762	4.47	No	No	0	7	8
775	R:R:L766	R:R:V789	2.98	No	No	0	7	8
776	R:R:L766	R:R:S792	4.5	No	No	0	7	8
777	R:R:L769	R:R:S792	3	No	No	0	7	8
778	R:R:T785	R:R:W770	3.64	No	No	0	7	6
779	R:R:R788	R:R:T785	15.52	No	No	0	7	7
780	R:R:K791	R:R:L841	2.82	No	No	0	8	5
781	R:R:L793	R:R:T797	2.95	No	No	0	7	9
782	R:R:F837	R:R:L794	12.18	No	No	0	8	6
783	R:R:L794	R:R:L841	4.15	No	No	0	6	5
784	R:R:G838	R:R:I795	3.53	No	No	0	8	7
785	R:R:P798	R:R:T797	3.5	Yes	No	0	9	9
786	R:R:F833	R:R:P798	2.89	Yes	Yes	14	7	9
787	R:R:F837	R:R:P798	2.89	No	Yes	14	8	9
788	R:R:L799	R:R:L800	2.77	Yes	Yes	0	6	9
789	R:R:L826	R:R:T803	8.84	No	No	0	6	9
790	R:R:N827	R:R:T803	4.39	Yes	No	0	9	9
791	R:R:F823	R:R:W804	4.01	Yes	Yes	6	9	9
792	R:R:N827	R:R:W804	15.82	Yes	Yes	6	9	9
793	R:R:Q830	R:R:W804	6.57	No	Yes	0	9	9
794	R:R:G807	R:R:T810	5.46	No	Yes	6	9	7
795	R:R:F823	R:R:G807	3.01	Yes	No	6	9	9
796	R:R:G809	R:R:I808	3.53	No	No	0	7	7
797	R:R:G809	R:R:W819	4.22	No	No	0	7	6
798	R:R:H820	R:R:T810	5.48	Yes	Yes	6	8	7
799	R:R:F823	R:R:T810	3.89	Yes	Yes	6	9	7
800	R:R:D813	R:R:V812	4.38	No	No	0	4	6
801	R:R:H820	R:R:S814	5.58	Yes	No	0	8	5
802	R:R:A818	R:R:N816	4.69	No	No	0	6	5
803	R:R:N816	R:R:W819	7.91	No	No	0	5	6
804	R:R:F823	R:R:N827	15.71	Yes	Yes	6	9	9
805	R:R:F829	R:R:L825	3.65	Yes	No	0	7	5
806	R:R:F829	R:R:F832	9.65	Yes	Yes	14	7	5
807	R:R:F829	R:R:F833	3.22	Yes	Yes	14	7	7
808	R:R:F832	R:R:F833	5.36	Yes	Yes	14	5	7
809	R:R:C836	R:R:F832	6.98	No	Yes	0	7	5
810	R:R:F833	R:R:F837	3.22	Yes	No	14	7	8
811	R:R:C836	R:R:L840	3.17	No	No	0	7	7
812	R:R:I839	R:R:L845	4.28	No	No	0	7	8
813	R:R:D842	R:R:K844	4.15	No	No	0	9	8
814	R:R:D842	R:R:L845	8.14	No	No	0	9	8
815	R:R:K844	R:R:L848	5.64	No	No	0	8	7
816	R:R:V591	R:R:W587	2.45	No	No	0	7	4
817	R:R:F610	R:R:L845	2.44	No	No	0	8	8
818	R:R:F806	R:R:L826	2.44	No	No	0	8	6
819	R:R:F833	R:R:L826	2.44	Yes	No	0	7	6
820	B:B:L190	B:B:R150	2.43	Yes	Yes	0	5	6
821	B:B:L192	B:B:R150	2.43	No	Yes	0	5	6
822	B:B:L284	B:B:R283	2.43	No	Yes	0	5	9
823	B:B:F292	B:B:N313	2.42	No	No	0	4	7
824	B:B:I157	B:B:W169	2.35	No	Yes	0	7	8
825	A:A:E370	A:A:R373	2.33	No	Yes	0	4	5
826	A:A:D354	A:A:Y358	2.3	No	No	0	3	4
827	B:B:H62	B:B:Y105	2.18	No	Yes	0	6	6
828	A:A:G225	A:A:G226	2.11	No	No	0	9	9
829	B:B:G115	B:B:G116	2.11	No	No	0	9	9
830	B:B:A231	B:B:G244	1.95	No	No	0	5	5
831	B:B:A248	B:B:G272	1.95	No	No	0	5	4
832	B:B:A309	B:B:G310	1.95	No	No	0	3	5
833	R:R:A828	R:R:G592	1.95	No	No	0	8	9
834	R:R:A660	R:R:G644	1.95	No	No	0	7	6
835	B:B:A106	B:B:P107	1.87	No	No	0	6	6
836	A:A:G47	A:A:S51	1.86	No	Yes	0	9	9
837	A:A:G353	A:A:S352	1.86	No	No	0	4	5
838	B:B:G319	B:B:S277	1.86	No	No	0	5	5
839	B:B:G282	B:B:S281	1.86	No	No	0	9	9
840	B:B:G306	B:B:V296	1.84	No	Yes	0	4	5
841	B:B:G319	B:B:V320	1.84	No	No	0	5	7
842	R:R:G592	R:R:V591	1.84	No	No	0	9	7
843	R:R:G644	R:R:V647	1.84	No	No	0	6	5
844	R:R:G679	R:R:V761	1.84	No	No	0	9	8
845	R:R:G702	R:R:V701	1.84	Yes	No	0	7	6
846	R:R:G790	R:R:V789	1.84	No	No	0	5	8
847	R:R:G809	R:R:V812	1.84	No	No	0	7	6
848	B:B:G185	B:B:T164	1.82	No	No	0	5	6
849	R:R:G655	R:R:T658	1.82	No	No	0	3	6
850	B:B:A60	B:B:C103	1.81	No	No	0	7	8
851	R:R:A631	R:R:C603	1.81	No	No	0	8	7
852	R:R:A660	R:R:C657	1.81	No	No	0	7	9
853	R:R:G594	R:R:I597	1.76	No	Yes	0	5	7
854	R:R:P743	R:R:T721	1.75	Yes	No	0	8	9
855	B:B:G324	B:B:K280	1.74	No	No	0	9	1
856	B:B:G310	B:B:K337	1.74	No	Yes	0	5	6
857	A:A:A351	A:A:S352	1.71	No	No	0	4	5
858	B:B:C233	B:B:V276	1.71	No	No	0	3	6
859	R:R:G679	R:R:L678	1.71	No	Yes	0	9	8
860	R:R:G679	R:R:L800	1.71	No	Yes	0	9	9
861	R:R:G708	R:R:L711	1.71	No	No	0	6	7
862	A:A:A298	A:A:V334	1.7	No	Yes	0	4	4
863	B:B:A257	G:G:V30	1.7	No	No	0	7	8
864	B:B:A305	B:B:V296	1.7	No	Yes	0	4	5
865	R:R:A824	R:R:V585	1.7	No	No	0	8	8
866	A:A:C379	A:A:T242	1.69	No	No	0	8	8
867	R:R:I581	R:R:P583	1.69	Yes	No	0	4	1
868	R:R:I834	R:R:P798	1.69	No	Yes	0	9	9
869	B:B:D170	B:B:G174	1.68	Yes	No	0	9	4
870	A:A:G226	A:A:Q227	1.64	No	Yes	0	9	9
871	R:R:C709	R:R:I713	1.64	No	No	0	8	9
872	B:B:S207	B:B:T223	1.6	No	No	0	5	2
873	A:A:G353	A:A:H357	1.59	No	No	0	4	7
874	B:B:A240	B:B:L252	1.58	No	No	0	6	7
875	B:B:A240	G:G:L37	1.58	No	No	0	6	7
876	R:R:A631	R:R:L604	1.58	No	No	0	8	8
877	R:R:A608	R:R:L609	1.58	No	No	0	5	4
878	R:R:A694	R:R:L697	1.58	No	No	0	8	3
879	R:R:I588	R:R:V821	1.54	No	No	0	9	7
880	R:R:I716	R:R:V720	1.54	No	No	0	7	5
881	R:R:I822	R:R:V821	1.54	No	No	0	5	7
882	A:A:C365	A:A:Q294	1.53	No	Yes	0	8	6
883	A:A:A39	A:A:Q35	1.52	No	No	0	5	3
884	R:R:K586	R:R:T567	1.5	No	No	0	3	9
885	R:R:K728	R:R:T658	1.5	No	No	0	5	6
886	A:A:L302	A:A:V301	1.49	No	No	0	2	7
887	R:R:L676	R:R:V757	1.49	No	No	0	7	7
888	R:R:L766	R:R:V762	1.49	No	No	0	7	8
889	R:R:L800	R:R:V762	1.49	Yes	No	0	9	8
890	R:R:I686	R:R:I687	1.47	Yes	No	0	7	6
891	A:A:N218	A:A:T40	1.46	No	No	0	4	7
892	A:A:D331	A:A:V334	1.46	No	Yes	0	4	4
893	B:B:N88	B:B:T86	1.46	No	No	0	7	6
894	B:B:A206	B:B:H225	1.46	No	Yes	0	4	9
895	R:R:I787	R:R:K791	1.45	No	No	0	4	8
896	A:A:F312	A:A:P313	1.44	No	No	0	8	6
897	B:B:M217	G:G:M21	1.44	No	No	0	3	1
898	A:A:I235	A:A:L44	1.43	No	Yes	0	9	9
899	A:A:I235	A:A:L46	1.43	No	No	0	9	8
900	A:A:I235	A:A:L282	1.43	No	No	0	9	9
901	A:A:L393	R:R:I795	1.43	Yes	No	19	8	7
902	R:R:I795	R:R:L796	1.43	No	No	19	7	9
903	A:A:E390	R:R:T619	1.41	No	Yes	0	4	8
904	B:B:G64	B:B:W63	1.41	No	Yes	0	5	7
905	G:G:K14	G:G:L15	1.41	No	No	0	4	2
906	A:A:K211	A:A:N218	1.4	No	No	0	4	4
907	A:A:K274	A:A:N278	1.4	No	No	0	5	8
908	G:G:K20	G:G:N24	1.4	No	No	0	6	1
909	A:A:A372	A:A:F212	1.39	No	No	0	8	9
910	B:B:A299	B:B:F278	1.39	No	Yes	0	5	7
911	R:R:A645	R:R:F641	1.39	No	Yes	0	7	9
912	B:B:D303	B:B:K301	1.38	No	No	0	2	5
913	A:A:D295	A:A:L296	1.36	No	No	0	9	6
914	A:A:D49	A:A:N50	1.35	No	No	0	8	9
915	G:G:E47	G:G:K46	1.35	No	No	0	3	1
916	B:B:H266	B:B:I269	1.33	No	No	0	4	4
917	B:B:D322	B:B:D323	1.33	No	No	0	1	7
918	A:A:D295	A:A:E299	1.3	No	No	0	9	6
919	R:R:H691	R:R:L688	1.29	No	No	0	7	6
920	B:B:E260	B:B:Q259	1.27	Yes	No	0	6	6
921	B:B:I123	B:B:R137	1.25	Yes	No	15	6	5
922	B:B:I171	B:B:R137	1.25	No	No	15	6	5
923	R:R:K730	R:R:R729	1.24	No	No	0	2	5
924	R:R:V755	R:R:W804	1.23	No	Yes	0	8	9
925	R:R:F759	R:R:L763	1.22	No	No	0	4	4
926	R:R:F759	R:R:L802	1.22	No	No	0	4	7
927	R:R:L769	R:R:R788	1.21	No	No	0	7	7
928	G:G:D26	G:G:R27	1.19	No	No	0	1	8

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	A:A:Y37	5.795	4	1	4
2	A:A:H41	4.29	5	7	6
3	A:A:L44	5.5225	4	1	9
4	A:A:S51	2.8625	4	0	9
5	A:A:I56	4.854	5	11	7
6	A:A:V217	3.3125	4	7	5
7	A:A:F219	4.72833	6	7	8
8	A:A:M221	4.27	4	0	8
9	A:A:F222	8.735	4	0	7
10	A:A:Q227	4.44429	7	1	9
11	A:A:K233	6.68333	6	1	9
12	A:A:W234	5.37	4	1	9
13	A:A:F238	6.14	5	1	9
14	A:A:I245	3.52	4	0	7
15	A:A:V247	3.33	4	0	7
16	A:A:V248	4.54	4	0	7
17	A:A:D249	7.855	4	17	8
18	A:A:D252	6.035	4	17	8
19	A:A:F273	4.565	6	5	9
20	A:A:W277	8.732	5	5	6
21	A:A:W281	11.12	4	1	5
22	A:A:I288	4.975	4	0	9
23	A:A:F290	3.5	6	11	9
24	A:A:L291	4.33	4	5	8
25	A:A:N292	4.4675	4	11	9
26	A:A:Q294	5.99	5	5	6
27	A:A:V334	2.3525	4	0	4
28	A:A:Y339	4.7575	4	5	3
29	A:A:F340	9.1525	4	0	7
30	A:A:R342	7.19	4	5	4
31	A:A:E344	4.7925	4	0	5
32	A:A:F345	6.236	5	0	8
33	A:A:S349	4.12	5	5	7
34	A:A:C359	3.418	5	5	5
35	A:A:Y360	5.786	5	18	8
36	A:A:F363	6.892	5	5	5
37	A:A:T364	5.19833	6	11	9
38	A:A:R373	3.525	4	7	5
39	A:A:F376	4.97	8	7	8
40	A:A:I382	5.9025	4	18	6
41	A:A:I383	3.08	4	7	8
42	A:A:L388	2.8425	4	0	8
43	A:A:Y391	6.544	5	0	4
44	A:A:L393	3.875	4	19	8
45	B:B:M45	6.105	4	3	4
46	B:B:R48	4.6075	4	13	7
47	B:B:L51	7.1775	4	0	9
48	B:B:H54	7.05857	7	1	9
49	B:B:L55	7.1925	4	1	6
50	B:B:K57	10.368	5	1	9
51	B:B:Y59	8.84	4	1	8
52	B:B:W63	6.562	5	21	7
53	B:B:S72	5.3	4	1	9
54	B:B:Q75	7.09	6	1	9
55	B:B:D76	5.95	6	1	9
56	B:B:L79	3.6675	4	9	7
57	B:B:I80	6.125	4	1	8
58	B:B:I81	5.654	5	9	7
59	B:B:W82	9.07	6	1	9
60	B:B:K89	7.4575	4	1	9
61	B:B:L95	5.3725	4	9	8
62	B:B:W99	9.835	4	1	9
63	B:B:M101	3.9925	4	1	9
64	B:B:Y105	4.202	5	9	6
65	B:B:Y111	6.535	4	0	4
66	B:B:L117	3.482	5	1	9
67	B:B:I120	4.5475	4	22	6
68	B:B:I123	4.1825	4	15	6
69	B:B:E138	6.405	4	22	6
70	B:B:H142	7.172	5	10	9
71	B:B:Y145	5.56875	8	1	8
72	B:B:R150	4.0825	4	0	6
73	B:B:F151	5.42667	6	15	9
74	B:B:L152	4.3525	4	0	3
75	B:B:T159	5.4825	4	10	9
76	B:B:C166	4.235	4	8	8
77	B:B:L168	5.1025	4	8	6
78	B:B:W169	6.53571	7	10	8
79	B:B:D170	3.6025	4	24	9
80	B:B:F180	7.08333	6	8	7
81	B:B:H183	8.545	4	0	9
82	B:B:D186	8.112	5	1	9
83	B:B:M188	4.51	5	1	8
84	B:B:L190	4.3775	4	0	5
85	B:B:L198	3.495	4	25	3
86	B:B:F199	7.008	5	8	9
87	B:B:V200	6.53	4	2	6
88	B:B:S201	4.6225	4	8	9
89	B:B:C204	5.945	4	1	7
90	B:B:K209	10.332	5	8	6
91	B:B:L210	6.23	4	0	5
92	B:B:W211	9.43	5	8	8
93	B:B:Q220	7.1675	4	2	7
94	B:B:F222	6.27	5	2	8
95	B:B:H225	7.39429	7	2	9
96	B:B:D228	6.3225	4	1	9
97	B:B:I229	4.365	4	2	7
98	B:B:I232	4.67143	7	2	8
99	B:B:F234	4.902	5	2	5
100	B:B:F235	7.524	5	2	6
101	B:B:P236	6.0025	4	2	7
102	B:B:N237	7.605	4	2	5
103	B:B:F241	5.57	6	2	6
104	B:B:T243	6.104	5	2	8
105	B:B:D247	7.6775	4	2	9
106	B:B:T249	5.885	4	2	6
107	B:B:R251	10.976	5	2	8
108	B:B:F253	9.624	5	2	6
109	B:B:D254	5.3725	4	26	9
110	B:B:R256	6.166	5	26	9
111	B:B:E260	10.8625	4	0	6
112	B:B:Y264	5.495	6	2	5
113	B:B:F278	3.35667	6	2	7
114	B:B:R283	5.59	4	28	9
115	B:B:Y289	6.24667	6	2	7
116	B:B:C294	4.215	4	3	5
117	B:B:V296	2.835	6	3	5
118	B:B:W297	8.685	4	2	8
119	B:B:L308	5.6625	4	3	7
120	B:B:H311	7.515	4	3	9
121	B:B:R314	8.152	5	1	8
122	B:B:V327	4.7575	4	0	6
123	B:B:T329	5.76	4	3	8
124	B:B:W332	6.45667	6	1	9
125	B:B:L336	6.3875	4	1	7
126	B:B:K337	5.112	5	3	6
127	B:B:W339	5.966	5	3	9
128	G:G:Q18	6.2825	4	8	9
129	G:G:Y40	10.25	4	2	6
130	R:R:F569	4.46833	6	6	9
131	R:R:S574	4.065	4	0	9
132	R:R:I581	3.4	4	29	4
133	R:R:L593	4.3475	4	6	8
134	R:R:I597	2.9775	4	0	7
135	R:R:T619	6.5375	4	0	8
136	R:R:R624	4.7775	4	0	9
137	R:R:L634	5.7975	4	0	9
138	R:R:D638	4.2775	4	0	7
139	R:R:F641	3.1625	4	0	9
140	R:R:H665	4.915	4	12	9
141	R:R:F666	5.4525	4	0	7
142	R:R:Y668	5.235	6	6	8
143	R:R:L669	3.8375	4	12	9
144	R:R:L671	4.118	5	30	7
145	R:R:W674	6.40833	6	4	9
146	R:R:M675	4.09	4	30	9
147	R:R:L678	3.43	4	0	8
148	R:R:L681	5.67	4	0	7
149	R:R:Y684	5.77	4	4	8
150	R:R:I686	2.938	5	20	7
151	R:R:F690	5.32333	6	7	8
152	R:R:Q695	6.4575	4	0	6
153	R:R:M698	4.9625	4	4	8
154	R:R:G702	3.165	4	4	7
155	R:R:P710	4.722	5	12	9
156	R:R:Y727	7.5575	4	31	9
157	R:R:L735	7.0625	4	0	9
158	R:R:W737	6.422	5	0	6
159	R:R:P743	4.602	5	0	8
160	R:R:P798	2.7425	4	14	9
161	R:R:L799	4.21	4	0	6
162	R:R:L800	3.5525	4	0	9
163	R:R:W804	7.78571	7	6	9
164	R:R:T810	4.55833	6	6	7
165	R:R:H820	7.7775	4	6	8
166	R:R:F823	5.80333	6	6	9
167	R:R:N827	9.885	4	6	9
168	R:R:F829	5.262	5	14	7
169	R:R:F832	6.1575	4	14	5
170	R:R:F833	3.426	5	14	7
171	W:W:?1	6.37111	9	4	0

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	A:A:L30	B:B:L55	35.5568	2.77	No	Yes	1	5	6
2	A:A:K34	B:B:L55	100	5.64	No	Yes	0	4	6
3	A:A:K34	R:R:Q695	71.0475	6.78	No	Yes	0	4	6
4	B:B:D76	B:B:L55	64.6842	10.86	Yes	Yes	1	9	6
5	A:A:K34	A:A:R38	29.2272	7.43	No	No	0	4	4
6	A:A:Y37	B:B:D76	54.062	3.45	Yes	Yes	1	4	9
7	A:A:Y37	B:B:Q75	52.5293	3.38	Yes	Yes	1	4	9
8	A:A:R38	R:R:H692	29.055	7.9	No	No	0	4	6
9	A:A:H41	R:R:H692	29.0057	3.58	Yes	No	0	6	6
10	A:A:F219	A:A:H41	39.3735	4.53	Yes	Yes	7	8	6
11	A:A:H41	A:A:I383	15.4137	2.65	Yes	Yes	7	6	8
12	A:A:F212	A:A:F219	37.6266	8.57	No	Yes	0	9	8
13	A:A:F212	A:A:M221	37.1726	2.49	No	Yes	0	9	8
14	A:A:I245	A:A:M221	36.2467	2.92	Yes	Yes	0	7	8
15	B:B:Q75	B:B:W99	48.1033	9.86	Yes	Yes	1	9	9
16	A:A:S51	A:A:V247	25.1111	3.23	Yes	Yes	0	9	7
17	A:A:F290	A:A:V247	25.716	2.62	Yes	Yes	0	9	7
18	A:A:F290	A:A:I245	34.8423	2.51	Yes	Yes	0	9	7
19	A:A:D249	A:A:S51	23.8974	2.94	Yes	Yes	0	8	9
20	B:B:L117	B:B:W99	46.4908	3.42	Yes	Yes	1	9	9
21	B:B:L117	B:B:Y145	45.6477	3.52	Yes	Yes	1	9	8
22	A:A:E230	A:A:K233	37.6141	6.75	No	Yes	1	9	9
23	A:A:K233	B:B:Y145	36.5453	3.58	Yes	Yes	1	9	8
24	A:A:E230	A:A:R228	37.5953	5.82	No	No	0	9	9
25	A:A:R228	B:B:T164	37.4719	5.17	No	No	0	9	6
26	A:A:L291	A:A:Q294	13.5877	5.32	Yes	Yes	5	8	6
27	A:A:Q294	A:A:S250	20.3055	5.78	Yes	No	0	6	6
28	A:A:L297	A:A:S250	20.5478	6.01	No	No	0	8	6
29	A:A:L297	A:A:S251	21.0316	4.5	No	No	0	8	9
30	A:A:L296	A:A:S251	21.5147	9.01	No	No	0	6	9
31	A:A:K293	A:A:L296	22.2377	4.23	No	No	0	9	6
32	A:A:D249	A:A:K293	22.4782	9.68	Yes	No	0	8	9
33	A:A:I383	A:A:N387	16.1261	2.83	Yes	No	0	8	8
34	R:R:M699	R:R:Q695	70.6772	4.08	No	Yes	0	7	6
35	R:R:I625	R:R:M699	70.2111	2.92	No	No	4	7	7
36	R:R:I625	W:W:?1	70.2038	3.47	No	Yes	4	7	0
37	A:A:Y391	R:R:L681	13.472	4.69	Yes	Yes	0	4	7
38	A:A:N387	R:R:R685	16.0435	9.64	No	No	0	8	8
39	R:R:C626	W:W:?1	60.6077	2.57	No	Yes	0	7	0
40	R:R:C626	R:R:L678	59.8252	3.17	No	Yes	0	7	8
41	R:R:L678	R:R:L799	58.6278	4.15	Yes	Yes	0	8	6
42	R:R:L799	R:R:L800	14.8656	2.77	Yes	Yes	0	6	9
43	R:R:G679	R:R:L678	15.1124	1.71	No	Yes	0	9	8
44	R:R:G679	R:R:L800	14.5931	1.71	No	Yes	0	9	9
45	B:B:K89	B:B:W82	35.2526	13.92	Yes	Yes	1	9	9
46	B:B:S72	B:B:W82	35.2446	4.94	Yes	Yes	1	9	9
47	B:B:M61	B:B:S72	93.2434	3.07	No	Yes	0	6	9
48	B:B:L70	B:B:M61	92.9778	5.65	No	No	0	5	6
49	B:B:L70	B:B:W63	92.4748	9.11	No	Yes	21	5	7
50	B:B:T321	B:B:W63	92.176	10.92	No	Yes	0	7	7
51	B:B:D323	B:B:T321	91.7723	7.23	No	No	0	7	7
52	B:B:D323	B:B:M325	91.5021	5.54	No	No	0	7	5
53	B:B:M325	G:G:P49	91.3667	6.71	No	No	0	5	7
54	G:G:D48	G:G:P49	91.2311	3.22	No	No	0	9	7
55	B:B:S279	G:G:D48	10.896	4.42	No	No	0	9	9
56	B:B:D76	B:B:S74	58.6278	4.42	Yes	No	0	9	9
57	B:B:H54	B:B:S74	58.5697	12.55	Yes	No	0	9	9
58	B:B:G185	B:B:T164	37.3484	1.82	No	No	0	5	6
59	B:B:D205	B:B:G185	37.2247	5.03	No	No	0	9	5
60	B:B:D205	B:B:S207	36.9766	4.42	No	No	0	9	5
61	B:B:H183	B:B:S207	36.7276	5.58	Yes	No	0	9	5
62	B:B:H183	B:B:S201	25.8233	2.79	Yes	Yes	0	9	9
63	B:B:F199	B:B:L190	21.2835	6.09	Yes	Yes	0	9	5
64	B:B:L190	B:B:R150	27.1769	2.43	Yes	Yes	0	5	6
65	B:B:H62	B:B:R150	25.3917	4.51	No	Yes	0	6	6
66	B:B:F199	B:B:W211	15.7061	10.02	Yes	Yes	8	9	8
67	B:B:H183	B:B:K209	10.6619	17.03	Yes	Yes	0	9	6
68	B:B:H62	B:B:Y105	24.7934	2.18	No	Yes	0	6	6
69	B:B:V71	B:B:Y105	16.9657	7.57	No	Yes	9	8	6
70	B:B:L79	B:B:V71	15.7574	2.98	Yes	No	9	7	8
71	B:B:L79	B:B:L95	12.1458	5.54	Yes	Yes	9	7	8
72	B:B:G162	B:B:Y145	12.9332	2.9	No	Yes	1	9	8
73	B:B:G162	B:B:S161	14.9696	3.71	No	No	0	9	9
74	B:B:H142	B:B:S161	13.1431	16.74	Yes	No	0	9	9
75	B:B:S281	G:G:D48	84.4802	10.31	No	No	0	9	9
76	B:B:G282	B:B:S281	84.3345	1.86	No	No	0	9	9
77	B:B:G282	B:B:P236	50.8958	4.06	No	Yes	2	9	7
78	B:B:F235	B:B:P236	26.0359	10.11	Yes	Yes	2	6	7
79	B:B:F235	B:B:N237	47.9754	12.08	Yes	Yes	2	6	5
80	B:B:G238	B:B:N237	66.1423	3.39	No	Yes	2	7	5
81	B:B:F234	B:B:G238	64.9934	3.01	Yes	No	2	5	7
82	B:B:F234	B:B:S191	17.4194	3.96	Yes	No	0	5	8
83	B:B:I232	B:B:S191	16.8433	4.64	Yes	No	0	8	8
84	B:B:F278	B:B:G282	33.2927	3.01	Yes	No	2	7	9
85	B:B:F235	B:B:F278	26.5057	6.43	Yes	Yes	2	6	7
86	B:B:P236	G:G:Y40	24.7148	6.95	Yes	Yes	2	7	6
87	B:B:N237	G:G:Y40	23.8025	8.14	Yes	Yes	2	5	6
88	B:B:F234	B:B:V200	46.4498	10.49	Yes	Yes	2	5	6
89	B:B:I232	B:B:V200	16.8669	4.61	Yes	Yes	2	8	6
90	B:B:F241	B:B:V200	22.0966	6.55	Yes	Yes	2	6	6
91	B:B:I229	B:B:I232	15.1128	2.94	Yes	Yes	2	7	8
92	B:B:F241	B:B:F253	12.2181	6.43	Yes	Yes	2	6	6
93	B:B:H225	B:B:I229	13.9538	7.95	Yes	Yes	2	9	7
94	B:B:I232	B:B:T243	15.1135	7.6	Yes	Yes	2	8	8
95	B:B:H225	B:B:T243	20.9315	8.21	Yes	Yes	2	9	8
96	B:B:D247	B:B:H225	13.9653	3.78	Yes	Yes	2	9	9
97	B:B:H225	B:B:R251	17.4579	14.67	Yes	Yes	2	9	8
98	R:R:I630	R:R:L799	43.6032	2.85	No	Yes	0	8	6
99	R:R:I630	R:R:L671	43.0375	2.85	No	Yes	30	8	7
100	R:R:L634	R:R:L671	10.1874	5.54	Yes	Yes	0	9	7
101	R:R:F672	R:R:L671	21.8448	4.87	No	Yes	0	9	7
102	R:R:F672	R:R:W804	21.4591	19.04	No	Yes	0	9	9
103	R:R:T664	R:R:Y668	10.242	2.5	No	Yes	0	7	8
104	R:R:L671	R:R:S633	11.5266	4.5	Yes	No	0	7	8
105	R:R:S633	R:R:S670	11.3224	4.89	No	No	0	8	8
106	R:R:P710	R:R:S670	11.1249	3.56	Yes	No	0	9	8
107	R:R:F666	R:R:P710	11.4367	2.89	Yes	Yes	0	7	9
108	R:R:L800	R:R:N758	24.8824	8.24	Yes	No	0	9	9
109	R:R:I754	R:R:N758	24.3053	4.25	No	No	0	9	9
110	R:R:F673	R:R:I754	23.1335	3.77	No	No	0	8	9
111	R:R:F673	R:R:P710	21.9695	10.11	No	Yes	12	8	9
112	R:R:L669	R:R:P710	21.3514	3.28	Yes	Yes	12	9	9
113	R:R:H665	R:R:L669	18.9872	5.14	Yes	Yes	12	9	9
114	R:R:L735	R:R:P743	14.0374	6.57	Yes	Yes	0	9	8
115	R:R:G740	R:R:P743	11.1418	6.09	No	Yes	0	4	8
116	A:A:L30	B:B:K89	35.2722	2.82	No	Yes	1	5	9
117	B:B:H54	B:B:S72	57.5583	4.18	Yes	Yes	1	9	9
118	A:A:Y391	R:R:L678	14.0213	4.69	Yes	Yes	0	4	8

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
A:A:Y391	R:R:L678	4.69	0	Yes	Yes	4	8	2	2
A:A:Y391	R:R:L681	4.69	0	Yes	Yes	4	7	2	1
R:R:H621	R:R:I625	3.98	4	No	No	6	7	2	1
R:R:H621	R:R:M699	2.63	4	No	No	6	7	2	2
R:R:L681	R:R:T622	2.95	0	Yes	No	7	7	1	2
R:R:M698	R:R:T622	3.01	4	Yes	No	8	7	1	2
R:R:I625	R:R:M699	2.92	4	No	No	7	7	1	2
R:R:I625	W:W:?1	3.47	4	No	Yes	7	0	1	0
R:R:C626	R:R:W674	2.61	0	No	Yes	7	9	1	2
R:R:C626	R:R:L678	3.17	0	No	Yes	7	8	1	2
R:R:C626	W:W:?1	2.57	0	No	Yes	7	0	1	0
R:R:G702	R:R:W674	2.81	4	Yes	Yes	7	9	1	2
R:R:G702	R:R:M677	5.24	4	Yes	No	7	6	1	1
R:R:L705	R:R:M677	5.65	0	No	No	6	6	2	1
R:R:M677	W:W:?1	9.16	4	No	Yes	6	0	1	0
R:R:I680	W:W:?1	15.03	0	No	Yes	8	0	1	0
R:R:L681	R:R:R685	6.07	0	Yes	No	7	8	1	2
R:R:L681	W:W:?1	8.97	0	Yes	Yes	7	0	1	0
R:R:L688	R:R:Y684	5.86	4	No	Yes	6	8	1	1
R:R:M693	R:R:Y684	9.58	4	No	Yes	5	8	2	1
R:R:M698	R:R:Y684	4.79	4	Yes	Yes	8	8	1	1
R:R:Y684	W:W:?1	2.85	4	Yes	Yes	8	0	1	0
R:R:L688	W:W:?1	3.36	4	No	Yes	6	0	1	0
R:R:M693	R:R:M698	2.89	4	No	Yes	5	8	2	1
R:R:M698	W:W:?1	9.16	4	Yes	Yes	8	0	1	0
R:R:G702	W:W:?1	2.77	4	Yes	Yes	7	0	1	0
R:R:G702	R:R:V701	1.84	4	Yes	No	7	6	1	2
R:R:H691	R:R:L688	1.29	0	No	No	7	6	2	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

Similarity	Network Type	Name	Ligand	Description
69.23	Single	7WU4	K6G	7WU4-ADGRF1-K6G-Gi1/β1/γ2
58.33	Single	7WU3	K6G	7WU3-ADGRF1-K6G-Gs/β1/γ2
40.00	Single	5XSZ	Glyceryl-mono-oleate	5XSZ-LPA₆-Glyceryl-mono-oleate
40.00	Single	7WU5	K6G	7WU5-ADGRF1-K6G-Gi1/β1/γ2
30.77	Single	9CM3	Compound 187	9CM3-FFA2-TUG-1375-Compound 187-chim(NtGi1L-Gs-CtGq)/β1/γ2
30.77	Single	9K1C	DHA	9K1C-FFA1-DHA-Gi1/β1/γ2
28.57	Single	5KW2	PubChem 133053953	5KW2-FFA1-PubChem 133053953
28.57	Single	9JCO	LPC	9JCO-GPR4-LPC-chim(NtGi1-Gs)/β1/γ2
23.53	Single	9IYB	A1D5Q	9IYB-DP₂-Prostaglandin-A1D5Q-Gi1/β1/γ2
23.08	Single	8XXU	A1D5Q	8XXU-DP₂-A1D5Q-Gi1/β1/γ2
20.00	Single	8Y72	BMS-986122	8Y72-μ-Peptide-BMS-986122-Gi1/β1/γ2
20.00	Single	9JCQ	LPC	9JCQ-GPR4-LPC-chim(NtGi1-Gs)/β1/γ2
19.05	Single	5TZY	MK8666; AP8	5TZY-FFA1-MK8666; AP8
18.75	Single	6N48	PubChem 138454256	6N48-β₂-BI167107-PubChem 138454256
15.79	Single	8XXV	A1D5Q	8XXV-DP₂-Indomethacin-A1D5Q-Gi1/β1/γ2
15.38	Single	9NS9	Compound 187	9NS9-FFA2-TUG-1375-Compound 187-Gi1/β1/γ2
13.33	Single	7CKZ	Mevidalen	7CKZ-D₁-Dopamine-Mevidalen-Gs/β1/γ2
13.33	Single	7LJD	Mevidalen	7LJD-D₁-Dopamine-Mevidalen-Gs/β1/γ1
13.33	Single	7X2F	Mevidalen	7X2F-D₁-Dopamine-Mevidalen-Gs/β1/γ2
13.33	Single	8K9L	BMS-986122	8K9L-μ-Damgo-BMS-986122-Gi3/β1/γ1
13.33	Single	9JCP	LPC	9JCP-GPR4-LPC-chim(NtGi1-Gs-CtGq)/β1/γ2
12.50	Single	7LJC	Mevidalen	7LJC-D₁-SKF-81297-Mevidalen-Gs/β1/γ2
11.11	Single	6C1R	Avacopan; Na	6C1R-C5a₁-PMX53-Avacopan; Na
10.53	Single	8YYX	Leukotriene e4	8YYX-Oxoglutarate-Leukotriene e4-chim(Gi1-CtGq)/β1/γ2
10.53	Single	9CM7	AZ-1729	9CM7-FFA2-TUG-1375-AZ-1729-Gi1/β1/γ2
8.33	Single	4PXF	Octyl-Beta-D-Glucopyranoside	4PXF-Rhodopsin-Octyl-β-D-Glucopyranoside-Arrestin1 Finger Loop
7.14	Single	6KQI	Org27569	6KQI-CB₁-CP55940-Org27569
6.67	Single	6OBA	GTPL11074	6OBA-β₂-S-Alprenolol-GTPL11074
6.25	Single	9JCO	LPC	9JCO-GPR4-LPC-chim(NtGi1-Gs)/β1/γ2
5.88	Single	6C1Q	NDT9513727	6C1Q-C5a₁-PMX53-NDT9513727
5.88	Single	8G94	CD69	8G94-S1P₁-CD69-Gi1/β1/γ2
5.56	Single	5O9H	NDT9513727	5O9H-C5a₁-NDT9513727
5.56	Single	8IYX	YL-365	8IYX-GPR34-YL-365

PDB Summary
PDB	8G2Y
Class	B2
SubFamily	Adhesion
Type	Adhesion
SubType	ADGRF1
Species	Homo Sapiens
Ligand	-
Other Ligand(s)	LPC
Protein Partners	chim(Gs-CtGq)/Beta1/Gamma2
PDB Resolution	3.44
Date	2023-05-10
D.O.I.	doi.org/10.1038/s41467-023-38083-7

Net Summary
I_min	2.49
Number of Linked Nodes	729
Number of Links	928
Number of Hubs	171
Number of Links mediated by Hubs	606
Number of Communities	31
Number of Nodes involved in Communities	246
Number of Links involved in Communities	355

Path Summary
Number Of Nodes in MetaPath	119
Number Of Links MetaPath	118
Number of Shortest Paths	1568349
Length Of Smallest Path	3
Average Path Length	33.1277
Length of Longest Path	57
Minimum Path Strength	1.22
Average Path Strength	5.6358
Maximum Path Strength	18.635
Minimum Path Correlation	0.7
Average Path Correlation	0.982127
Maximum Path Correlation	1
Minimum % Of Corr. Nodes	2.7027
Average % Of Corr. Nodes	38.1477
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	51.805
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process	• cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cell communication • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular process • signal transduction • cell surface receptor signaling pathway • regulation of lipid metabolic process • primary metabolic process • metabolic process • regulation of metabolic process • lipid metabolic process • regulation of primary metabolic process • developmental process • fat cell differentiation • cellular developmental process • cell differentiation • behavior • multicellular organismal process • system process • learning or memory • nervous system process • cognition • memory • nervous system development • cellular component organization • cellular component biogenesis • multicellular organism development • cell junction organization • cellular component assembly • cell junction assembly • anatomical structure development • synapse organization • cellular component organization or biogenesis • synapse assembly • system development • energy derivation by oxidation of organic compounds • energy reserve metabolic process • generation of precursor metabolites and energy • plasma membrane bounded cell projection organization • cell projection organization • cell development • neuron projection development • generation of neurons • neurogenesis • neuron differentiation • neuron development • membrane-bounded organelle • intracellular organelle • cellular anatomical structure • intracellular anatomical structure • cytoplasmic vesicle • organelle • intracellular vesicle • cytoplasm • intracellular membrane-bounded organelle • vesicle • membrane • extracellular region • cell periphery • plasma membrane • protein binding • binding • G-protein beta-subunit binding • fibroblast proliferation • cell population proliferation • cellular response to nitrogen compound • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • response to oxygen-containing compound • response to nitrogen compound • cellular response to oxygen-containing compound • cellular response to chemical stimulus • cellular response to monoamine stimulus • response to chemical • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to alcohol • response to hormone • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • extracellular vesicle • extracellular organelle • extracellular space • extracellular membrane-bounded organelle • synapse • cell junction • enzyme binding • GTPase binding • protein-containing complex binding • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • sensory perception of chemical stimulus • sensory perception • sensory perception of taste • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • camera-type eye development • sensory system development • small GTPase-mediated signal transduction • Ras protein signal transduction • intracellular signal transduction • intracellular signaling cassette • phospholipase C-activating G protein-coupled receptor signaling pathway • synaptic signaling • cellular response to acetylcholine • cell-cell signaling • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • non-motile cilium • 9+0 non-motile cilium • cilium • neuron projection • photoreceptor disc membrane • photoreceptor outer segment • plasma membrane bounded cell projection • cell projection • photoreceptor cell cilium • organelle membrane • cytosol • vacuolar membrane • lytic vacuole • vacuole • lytic vacuole membrane • bounding membrane of organelle • lysosomal membrane • lysosome
Gene Ontology	Cellular Component
SCOP2	Domain Identifier
SCOP2	Family Identifier
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	LPC
PDB Residues	W:W:?1
Environment Details	Open EMBL-EBI Page
Code	LPC
Name	[1-MYRISTOYL-GLYCEROL-3-YL]PHOSPHONYLCHOLINE
Synonyms
Identifier
Formula	C22 H47 N O7 P
Molecular Weight	468.585
SMILES
PubChem	444675
Formal Charge	1
Total Atoms	78
Total Chiral Atoms	2
Total Bonds	77
Total Aromatic Bonds	0


PDBsum	Open PDBsum Page
Chain	A
Protein	G Protein α Sub unit
UniProt	P63092
Sequence	>8G2Y_Chain_A K I E K Q L Q K D K Q V Y R A T H R L L L L G A D N S G K S T I I F E T K F Q V D K V N F H M F D V G G Q R D E R R K W I Q C F N D V T A I I F V V D S S D Y N R L Q E A L N L F K S I W N N R W L R T I S V I L F L N K Q D L L A E K V L A Y F P E F A R Y T T P D P R V T R A K Y F I R D E F L R I S T A S G D G R H Y C Y P H F T C A V D T E N A R R I F N D C K D I I L Q M N L R E Y N L V Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

Chain	B
Protein	G Protein β Sub unit
UniProt	P62873
Sequence	>8G2Y_Chain_B G R I Q M R T R R T L R G H L A K I Y A M H W G L L V S A S Q D G K L I I W D S Y T T N K V H A I P L R S S W V M T C A Y A P S G N Y V A C G G L D N I C S I Y N L K V R V S R E L A G H T G Y L S C C R F L D D N Q I V T S S G D T T C A L W D I E T G Q Q T T T F T G H T G D V M S L S L A P D T R L F V S G A C D A S A K L W D V R E G M C R Q T F T G H E S D I N A I C F F P N G N A F A T G S D D A T C R L F D L R A D Q E L M T Y S H D N I I C G I T S V S F S K S G R L L L A G Y D D F N C N V W D A L K A D R A G V L A G H D N R V S C L G V T D D G M A V A T G S W D S F L K I W N Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

Chain	G
Protein	G Protein γ Sub unit
UniProt	P59768
Sequence	>8G2Y_Chain_G R K L V E Q L K M E A N I D R I K V S K A A A D L M A Y C E A H A K E D P L Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

Chain	R
Protein	Receptor
UniProt	Q5T601
Sequence	>8G2Y_Chain_R T S F S I L M S P F V P S T I F P V V K W I T Y V G L G I S I G S L I L C L I I E A L F W Q T S H T R R I C M V N I A L S L L I A D V W F I V G A T V G V C T A A V F F T H F F Y L S L F F W M L M L G I L L A Y R I I L V F H H M A Q H L M M A V G F C L G Y G C P L I I S V I T I A V T Q Y K R K D V C W L N W S N G S K P L L A F V V P A L A I V A V N F V V V L L V L T K L W T I I R V G K S L L I L T P L L G L T W G F G I G T I V D S Q N L A W H V I F A L L N A F Q G F F I L C F G I L L D S K L R Q L Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	8G2Y	B2	Adhesion	Adhesion	ADGRF1	Homo sapiens	-	LPC	chim(Gs-CtGq)/β1/γ2	3.44	2023-05-10	doi.org/10.1038/s41467-023-38083-7
	8G2Y (No Gprot)	B2	Adhesion	Adhesion	ADGRF1	Homo sapiens	-	LPC		3.44	2023-05-10	doi.org/10.1038/s41467-023-38083-7
	7WU3	B2	Adhesion	Adhesion	ADGRF1	Homo sapiens	-	K6G	Gs/β1/γ2	3.1	2022-04-27	doi.org/10.1038/s41586-022-04580-w
	7WU3 (No Gprot)	B2	Adhesion	Adhesion	ADGRF1	Homo sapiens	-	K6G		3.1	2022-04-27	doi.org/10.1038/s41586-022-04580-w
	7WU4	B2	Adhesion	Adhesion	ADGRF1	Homo sapiens	-	K6G	Gi1/β1/γ2	3.4	2022-04-27	doi.org/10.1038/s41586-022-04580-w
	7WU4 (No Gprot)	B2	Adhesion	Adhesion	ADGRF1	Homo sapiens	-	K6G		3.4	2022-04-27	doi.org/10.1038/s41586-022-04580-w
	7WU5	B2	Adhesion	Adhesion	ADGRF1	Homo sapiens	-	K6G	Gi1/β1/γ2	3	2022-04-27	doi.org/10.1038/s41586-022-04580-w
	7WU5 (No Gprot)	B2	Adhesion	Adhesion	ADGRF1	Homo sapiens	-	K6G		3	2022-04-27	doi.org/10.1038/s41586-022-04580-w
	7WXU	B2	Adhesion	Adhesion	ADGRF1	Homo sapiens	-	-	chim(NtGi1-Gs-CtGq)/β1/γ2	2.85	2022-09-28	doi.org/10.1038/s41467-022-33173-4
	7WXU (No Gprot)	B2	Adhesion	Adhesion	ADGRF1	Homo sapiens	-	-		2.85	2022-09-28	doi.org/10.1038/s41467-022-33173-4
	7WXW	B2	Adhesion	Adhesion	ADGRF1	Homo sapiens	-	-	chim(NtGi1-Gs)/β1/γ2	2.84	2022-09-28	doi.org/10.1038/s41467-022-33173-4
	7WXW (No Gprot)	B2	Adhesion	Adhesion	ADGRF1	Homo sapiens	-	-		2.84	2022-09-28	doi.org/10.1038/s41467-022-33173-4
	7WY0	B2	Adhesion	Adhesion	ADGRF1	Homo sapiens	-	-	chim(NtGi1L-G13)/β1/γ2	2.83	2022-09-28	doi.org/10.1038/s41467-022-33173-4
	7WY0 (No Gprot)	B2	Adhesion	Adhesion	ADGRF1	Homo sapiens	-	-		2.83	2022-09-28	doi.org/10.1038/s41467-022-33173-4
	7WZ7	B2	Adhesion	Adhesion	ADGRF1	Homo sapiens	-	-	chim(NtGi1-G12)/β1/γ2	2.83	2022-09-28	doi.org/10.1038/s41467-022-33173-4
	7WZ7 (No Gprot)	B2	Adhesion	Adhesion	ADGRF1	Homo sapiens	-	-		2.83	2022-09-28	doi.org/10.1038/s41467-022-33173-4
	7X2V	B2	Adhesion	Adhesion	ADGRF1	Homo sapiens	-	-	Gi1/β1/γ2	3.09	2022-09-28	doi.org/10.1038/s41467-022-33173-4
	7X2V (No Gprot)	B2	Adhesion	Adhesion	ADGRF1	Homo sapiens	-	-		3.09	2022-09-28	doi.org/10.1038/s41467-022-33173-4

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