Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg Int. Strength Num Of Links Community ConSurf
1A:A:I19 3.345409
2A:A:V34 7.005485
3A:A:L36 4.9325487
4A:A:K46 5.80754109
5A:A:I49 5.9525107
6A:A:I184 4.835419
7A:A:F191 7.7575485
8A:A:F196 8.02667687
9A:A:F199 8.618515
10A:A:V201 3.4575419
11A:A:Q204 5.452519
12A:A:S206 5.3675418
13A:A:E207 6.502519
14A:A:K210 6.32819
15A:A:W211 6.16519
16A:A:F215 6.61167619
17A:A:Y230 6.915628
18A:A:R242 4.7275409
19A:A:F250 6.36529
20A:A:N255 6.9325408
21A:A:W258 10.2025405
22A:A:I264 5.935426
23A:A:F267 5.043336109
24A:A:N269 5.5345109
25A:A:F274 6.6525429
26A:A:I278 4.2175426
27A:A:Y287 5.522527
28A:A:Y296 6.79667624
29A:A:Q304 6.534525
30A:A:F307 6.166528
31A:A:R313 4.7425404
32A:A:K317 6.6875407
33A:A:Y320 6.47429727
34A:A:F323 6.836524
35A:A:T324 6.13254109
36A:A:F334 10.0025403
37A:A:F336 5.9675488
38A:A:V339 3.7275488
39A:A:F354 6.3025405
40B:B:V40 4.6265153
41B:B:M45 4.3175404
42B:B:L51 7.89449
43B:B:H54 9.06549
44B:B:Y59 7.395618
45B:B:W63 6.78647
46B:B:V71 4.024128
47B:B:L79 6.1765127
48B:B:I81 4.2875407
49B:B:W82 9.25429749
50B:B:K89 6.44167649
51B:B:H91 4.8275405
52B:B:I93 5.87407
53B:B:L95 5.15754128
54B:B:W99 8.85819
55B:B:Y105 4.144506
56B:B:N110 5.90254134
57B:B:Y111 5.8825134
58B:B:L117 4.9125419
59B:B:Y124 6.43406
60B:B:E130 6.4754203
61B:B:H142 8.946519
62B:B:Y145 5.76375818
63B:B:L146 4.455417
64B:B:C148 3.5425406
65B:B:F151 4.815717139
66B:B:Q156 5.9325405
67B:B:T159 7.13419
68B:B:D163 7.434519
69B:B:C166 4.235458
70B:B:W169 8.95333618
71B:B:D170 6.74254219
72B:B:Q176 6.88414
73B:B:F180 8.418557
74B:B:H183 8.80833659
75B:B:D186 4.472519
76B:B:V187 4.748559
77B:B:M188 5.64418
78B:B:A193 3.0675404
79B:B:F199 6.93667659
80B:B:S201 4.915459
81B:B:C204 5.02517
82B:B:D205 5.96167659
83B:B:S207 4.57455
84B:B:K209 9.175656
85B:B:L210 5.222505
86B:B:W211 8.13667658
87B:B:F222 8.58478
88B:B:H225 8.84286779
89B:B:D228 7.014519
90B:B:I232 3.965408
91B:B:F235 7.65566
92B:B:P236 6.015467
93B:B:F241 7.456576
94B:B:D246 5.8275419
95B:B:T249 5.2925476
96B:B:R251 11.355678
97B:B:F253 6.88571776
98B:B:D258 8.925477
99B:B:M262 5.935464
100B:B:Y264 6.60167665
101B:B:I273 5.78406
102B:B:F278 6.015467
103B:B:R283 8.495159
104B:B:L285 4.535466
105B:B:Y289 7.72667667
106B:B:D290 9.3125406
107B:B:C294 4.6254145
108B:B:N295 8.705466
109B:B:V296 2.806505
110B:B:W297 6.8525468
111B:B:H311 9.1565149
112B:B:M325 5.6725405
113B:B:T329 5.38254148
114B:B:W332 12.1417619
115B:B:D333 8.784149
116B:B:L336 6.1447
117B:B:I338 4.145445
118B:B:W339 7.335409
119G:G:Y40 9.38466
120G:G:D48 6.894509
121G:G:N59 6.425409
122G:G:F61 4.77286748
123R:R:F569 4.872599
124R:R:S570 5.05254119
125R:R:L572 5.105499
126R:R:M573 5.8825409
127R:R:S574 3.726119
128R:R:P575 7.6954116
129R:R:V577 3.714113
130R:R:P578 4.1575404
131R:R:I581 3.79504
132R:R:Y590 2.16405
133R:R:F610 3.9525408
134R:R:K615 9.124538
135R:R:R624 7.6525439
136R:R:D638 5.6475407
137R:R:T649 3.98754163
138R:R:H665 5.37333609
139R:R:Y668 4.702598
140R:R:L669 4.6025409
141R:R:F672 8.205409
142R:R:W674 9.12667639
143R:R:M675 3.595409
144R:R:L676 4.66407
145R:R:M677 5.414536
146R:R:Y684 6.924538
147R:R:R685 7.48667638
148R:R:F690 6.238588
149R:R:H691 7.005437
150R:R:F703 6.4475438
151R:R:Y707 4.82439
152R:R:T721 5.195409
153R:R:T726 3.8975404
154R:R:Y727 5.835699
155R:R:K728 4.375165
156R:R:W734 5.34167698
157R:R:L735 5.252599
158R:R:L744 5.0025498
159R:R:F747 5.416598
160R:R:R777 8.744525
161R:R:V789 3.2425408
162R:R:W804 9.3325249
163R:R:H820 5.29754118
164W:W:?1 5.910771330
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
1B:B:D66 B:B:R68 1003.57NoNo085
2B:B:D66 B:B:L69 1005.43NoNo085
3B:B:I81 B:B:L69 1004.28YesNo075
4B:B:H91 B:B:I81 1003.98YesYes057
5B:B:I81 B:B:V71 1004.61YesYes078
6B:B:L79 B:B:V71 1004.47YesYes1278
7B:B:I93 B:B:L79 1008.56YesYes077
8B:B:L69 B:B:Y105 1003.52NoYes056
9B:B:V71 B:B:Y105 1003.79YesYes086
10B:B:H91 B:B:V133 1004.15YesNo054
11B:B:I93 B:B:V133 1003.07YesNo074
12B:B:I93 B:B:Y124 1008.46YesYes076
13B:B:S122 B:B:Y124 1005.09NoYes086
14B:B:I120 B:B:S122 1003.1NoNo068
15B:B:D118 B:B:I120 1007NoNo096
16B:B:D118 B:B:S97 1008.83NoNo098
17B:B:S97 B:B:W99 1003.71NoYes089
18A:A:F199 B:B:W99 12.130714.03YesYes159
19B:B:L79 B:B:L95 1005.54YesYes1278
20B:B:L95 B:B:Y124 1005.86YesYes086
21B:B:R68 B:B:Y85 10014.4NoNo054
22B:B:Y85 G:G:P60 10011.13NoNo049
23B:B:M325 G:G:P60 1006.71YesNo059
24B:B:M325 G:G:P49 1006.71YesNo057
25G:G:D48 G:G:P49 1003.22YesNo097
26B:B:S279 G:G:D48 1008.83NoYes099
27B:B:L284 B:B:S279 1006.01NoNo059
28B:B:L284 B:B:V296 1004.47NoYes055
29B:B:M45 B:B:V296 1003.04YesYes045
30B:B:L308 B:B:M45 1007.07NoYes074
31B:B:C294 B:B:L308 1006.35YesNo057
32B:B:C294 B:B:V315 1005.12YesNo1457
33B:B:H311 B:B:V315 1004.15YesNo1497
34B:B:D333 B:B:H311 1007.56YesYes1499
35B:B:D312 B:B:D333 1007.98NoYes059
36B:B:D312 R:R:K616 1005.53NoNo057
37R:R:K612 R:R:K616 10010.06NoNo077
38R:R:K612 R:R:K615 1005.75NoYes378
39R:R:K615 R:R:S620 1003.06YesNo388
40R:R:S617 R:R:S620 1003.26NoNo388
41R:R:S617 R:R:T619 1004.8NoNo388
42R:R:R685 R:R:T619 10012.94YesNo388
43R:R:L681 R:R:R685 1004.86NoYes078
44R:R:L681 R:R:T622 1007.37NoNo077
45R:R:T622 W:W:?1 1005.39NoYes070
46R:R:M677 W:W:?1 1009.04YesYes360
47R:R:L676 R:R:M677 1004.24YesYes076
48R:R:I754 R:R:L676 1007.14NoYes097
49R:R:I754 R:R:N758 1004.25NoNo099
50R:R:L800 R:R:N758 10010.98NoNo099
51R:R:L796 R:R:L800 1006.92NoNo099
52R:R:L796 R:R:V762 1004.47NoNo098
53R:R:L802 R:R:V762 1004.47NoNo078
54R:R:L802 R:R:T797 1008.84NoNo079
55R:R:L793 R:R:T797 1002.95NoNo079
56R:R:L766 R:R:L793 1005.54NoNo077
57R:R:L766 R:R:V789 1004.47NoYes078
58R:R:L769 R:R:V789 1002.98NoYes078
59R:R:L769 R:R:S792 1003NoNo078
60A:A:L353 R:R:S792 1007.51NoNo078
61A:A:L348 A:A:L353 1006.92NoNo097
62A:A:F354 A:A:L348 1008.53YesNo059
63A:A:F354 A:A:K345 1006.2YesNo055
64A:A:D341 A:A:K345 1008.3NoNo085
65A:A:D341 A:A:Y320 1005.75NoYes087
66A:A:A338 A:A:Y320 44.13695.34NoYes067
67A:A:A338 A:A:I265 42.79964.87NoNo068
68A:A:I222 A:A:I265 40.12495.89NoNo078
69A:A:I222 A:A:L36 38.78767.14NoYes077
70B:B:Y85 G:G:F61 1008.25NoYes048
71B:B:M325 G:G:F61 1003.73YesYes058
72B:B:C294 B:B:T329 1005.07YesYes1458
73B:B:H311 B:B:T329 1006.85YesYes1498
74B:B:L308 B:B:W339 10010.25NoYes079
75B:B:T329 B:B:W339 1004.85YesYes089
76B:B:K337 B:B:W339 1006.96NoYes069
77B:B:H311 B:B:K337 10010.48YesNo096
78R:R:R685 R:R:Y684 10010.29YesYes388
79R:R:L688 R:R:Y684 1007.03NoYes368
80R:R:L688 W:W:?1 10010.12NoYes360
81R:R:H691 R:R:Y684 1006.53YesYes378
82R:R:H691 W:W:?1 1005.87YesYes370
83R:R:M693 R:R:Y684 1007.18NoYes358
84R:R:M693 W:W:?1 1003.88NoYes350
85R:R:I680 W:W:?1 1006.52NoYes080
86R:R:I680 R:R:L676 1004.28NoYes087
87A:A:F196 A:A:L36 32.10023.65YesYes877
88A:A:F215 B:B:W99 19.355213.03YesYes199
89A:A:F215 A:A:L37 13.33524.87YesNo099
90A:A:L37 A:A:L39 12.1236.92NoNo099
91A:A:Y320 R:R:V774 1005.05YesNo275
92A:A:F334 R:R:V774 1005.24YesNo035
93A:A:F267 A:A:F334 52.14215.36YesYes093
94A:A:F267 A:A:I49 22.72887.54YesYes1097
95A:A:C224 A:A:I49 21.39214.91NoYes1077
96A:A:C224 A:A:K46 40.11034.85NoYes1079
97A:A:F267 A:A:N269 24.06583.62YesYes1099
98A:A:C224 A:A:N269 21.39213.15NoYes1079
99A:A:E318 A:A:Y320 1008.98NoYes247
100A:A:E318 R:R:R780 1009.3NoNo243
101A:A:E308 R:R:R780 1004.65NoNo233
102A:A:E308 A:A:T321 96.18614.23NoNo235
103A:A:L266 A:A:T321 93.53025.9NoNo295
104A:A:F250 A:A:L266 42.75143.65YesNo299
105A:A:Y320 R:R:R777 10011.32YesYes275
106R:R:R777 R:R:R780 1008.53YesNo253
107A:A:K46 A:A:S44 29.41453.06YesNo099
108A:A:D226 A:A:S44 24.06651.47NoNo089
109A:A:D226 A:A:D229 13.37042.66NoNo088
110A:A:D229 A:A:R242 10.69644.76NoYes089
111A:A:F334 A:A:H322 62.804324.89YesNo039
112A:A:H322 A:A:K330 10.69256.55NoNo094
113B:B:L117 B:B:W99 1005.69YesYes199
114A:A:Q204 B:B:L117 1003.99YesYes199
115A:A:F196 A:A:F336 14.71343.22YesYes878
116A:A:W211 B:B:L117 1005.69YesYes199
117A:A:Q204 B:B:Y145 1005.64YesYes198
118A:A:W211 B:B:Y145 1008.68YesYes198
119B:B:D118 B:B:G115 72.62363.35NoNo099
120B:B:G115 B:B:L146 71.41443.42NoYes097
121B:B:H142 B:B:L146 29.04493.86YesYes197
122A:A:K210 B:B:Y145 1003.58YesYes198
123A:A:K210 B:B:D246 1004.15YesYes199
124B:B:Q75 B:B:W99 1006.57NoYes199
125B:B:Q75 B:B:Y59 10010.15NoYes198
126B:B:W332 B:B:Y59 10011.58YesYes198
127A:A:E308 A:A:Q304 1007.65NoYes235
128A:A:L268 A:A:Q304 37.40363.99NoYes285
129A:A:L268 A:A:V225 34.73844.47NoNo287
130A:A:F307 A:A:V225 29.393910.49YesNo287
131A:A:F250 A:A:F307 29.39576.43YesYes298
132A:A:F323 A:A:Q304 98.86937.03YesYes245
133A:A:F323 A:A:Y296 1003.09YesYes244
134A:A:F274 A:A:Y296 1004.13YesYes294
135A:A:H322 R:R:E776 50.78378.62NoNo095
136A:A:F323 R:R:E776 98.89189.33YesNo045
137A:A:F334 R:R:G775 52.11564.52YesNo036
138R:R:E776 R:R:G775 50.783.27NoNo056
139A:A:F274 A:A:L227 10.68878.53YesNo097
140A:A:F274 A:A:Y230 74.81625.16YesYes298
141A:A:F274 A:A:I278 32.06398.79YesYes296
142A:A:L283 A:A:Y230 16.03217.03NoYes278
143A:A:F307 A:A:M243 48.09483.73YesNo088
144A:A:M243 A:A:Y287 42.75094.79NoYes087
145A:A:Y230 A:A:Y287 42.75435.96YesYes287
146A:A:H244 A:A:Y287 10.68765.44NoYes047
147A:A:I264 A:A:L266 48.10654.28YesNo269
148A:A:I264 A:A:K317 40.09195.82YesYes067
149A:A:C254 A:A:K317 10.69133.23NoYes057
150A:A:K317 A:A:R313 24.05543.71YesYes074
151B:B:R314 B:B:W332 10019.99NoYes089
152A:A:E275 A:A:Y296 21.377112.35NoYes054
153A:A:E275 A:A:E276 16.03283.81NoNo055
154A:A:I278 A:A:N294 21.3772.83YesNo063
155A:A:N294 A:A:P282 16.03283.26NoNo035
156A:A:A291 A:A:L283 10.68854.73NoNo037
157A:A:E289 A:A:Y287 64.12556.73NoYes067
158A:A:E289 A:A:Y302 42.75044.49NoNo066
159A:A:E297 A:A:Y296 32.06561.12NoYes044
160A:A:E297 A:A:T295 26.72149.88NoNo045
161A:A:S293 A:A:T295 21.37714.8NoNo035
162A:A:E298 A:A:S293 16.03285.75NoNo043
163A:A:E298 A:A:G292 10.68864.91NoNo047
164A:A:Q306 A:A:Y302 32.062814.65NoNo056
165A:A:C305 A:A:Q306 21.37521.53NoNo035
166A:A:C305 A:A:D309 10.68764.67NoNo034
167B:B:D246 B:B:S227 1004.42YesNo096
168B:B:D247 B:B:S227 1008.83NoNo096
169B:B:D247 B:B:E226 10012.99NoNo093
170B:B:E226 B:B:R251 1003.49NoYes038
171B:B:F253 B:B:R251 1004.28YesYes768
172B:B:F222 B:B:F253 10011.79YesYes786
173B:B:D258 B:B:F222 1004.78YesYes778
174B:B:D258 B:B:R22 1009.53YesNo076
175B:B:I18 B:B:R22 1005.01NoNo076
176B:B:I18 G:G:L19 1001.43NoNo079
177B:B:L14 G:G:L19 1005.54NoNo089
178B:B:L14 B:B:Q13 1006.65NoNo081
179B:B:E10 B:B:Q13 77.53555.1NoNo081
180B:B:E10 B:B:Q6 53.3062.55NoNo081
181B:B:L7 B:B:Q6 43.61415.32NoNo081
182B:B:L7 G:G:R13 33.92222.43NoNo086
183G:G:I9 G:G:R13 24.23028.77NoNo026
184B:B:L4 G:G:I9 14.53819.99NoNo042
185B:B:D247 B:B:S245 1004.42NoNo099
186B:B:H225 B:B:S245 10015.34YesNo799
187B:B:F253 B:B:H225 1003.39YesYes769
188B:B:N16 B:B:Q13 29.07621.32NoNo011
189B:B:N16 B:B:R19 14.538112.05NoNo014
190B:B:S316 B:B:Y59 1003.82NoYes198
191B:B:S316 B:B:T274 1003.2NoNo098
192B:B:D290 B:B:T274 1005.78YesNo068
193B:B:C271 B:B:D290 1003.11NoYes056
194B:B:C271 B:B:Y289 1005.38NoYes657
195B:B:W297 B:B:Y289 1006.75YesYes687
196B:B:L285 B:B:W297 1004.56YesYes668
197B:B:F278 B:B:L285 97.08367.31YesYes676
198B:B:F235 B:B:F278 48.5429.65YesYes667
199B:B:F235 G:G:Y40 38.8345.16YesYes666
200B:B:N237 G:G:Y40 63.105310.47NoYes056
201B:B:N237 B:B:N239 58.25118.17NoNo052
202B:B:N239 B:B:R256 53.396915.67NoNo029
203B:B:R256 G:G:I28 43.68858.77NoNo094
204G:G:A33 G:G:I28 38.83433.25NoNo074
205B:B:D254 G:G:A33 33.984.63NoNo097
206B:B:D254 B:B:L261 24.27154.07NoNo095
207B:B:L261 G:G:V30 19.41722.98NoNo058
208B:B:D290 B:B:R314 10025.01YesNo068
209B:B:F278 B:B:P236 43.68784.33YesYes677
210B:B:P236 G:G:Y40 38.83385.56YesYes676
211B:B:W297 B:B:Y264 36.403711.58YesYes685
212B:B:M262 B:B:Y264 29.126610.78YesYes645
213B:B:L30 B:B:M262 19.41795.65NoYes054
214B:B:L30 G:G:A34 16.99074.73NoNo056
215B:B:I33 G:G:A34 14.56351.62NoNo036
216B:B:I33 G:G:S31 12.13631.55NoNo039
217B:B:H62 B:B:Y105 15.23623.27NoYes066
218B:B:H62 B:B:R150 14.986714.67NoNo066
219B:B:C121 B:B:L146 25.42463.17NoYes187
220B:B:C121 B:B:L139 24.21296.35NoNo089
221B:B:I123 B:B:L139 23.024.28NoNo069
222B:B:H142 B:B:W169 14.57768.46YesYes198
223B:B:I157 B:B:W169 14.55223.52NoYes078
224B:B:F151 B:B:I157 12.129710.05YesNo097
225B:B:L146 B:B:T159 15.73827.37YesYes179
226B:B:T159 B:B:W169 14.527810.92YesYes198
227B:B:I123 B:B:Y111 15.7554.84NoYes1364
228B:B:H225 B:B:T243 26.65118.21YesNo798
229B:B:I232 B:B:T243 24.22943.04YesNo088
230B:B:I232 B:B:S191 19.38323.1YesNo088
231B:B:F241 B:B:F253 1009.65YesYes766
232B:B:F241 B:B:V200 72.68610.49YesNo066
233B:B:F234 B:B:V200 33.92097.87NoNo056
234B:B:F234 B:B:S191 16.96077.93NoNo058
235B:B:A193 B:B:F234 43.61144.16YesNo045
236B:B:A193 B:B:D195 21.80653.09YesNo045
237B:B:F222 B:B:Q220 38.76557.03YesNo787
238B:B:L210 B:B:Q220 33.92353.99YesNo057
239B:B:L198 B:B:L210 14.53896.92NoYes035
240B:B:L210 B:B:V200 33.92074.47YesNo056
241B:B:F241 B:B:L255 38.76583.65YesNo066
242B:B:L210 B:B:L255 33.92018.3YesNo056
243B:B:A193 B:B:P194 14.53771.87YesNo044
244B:B:D195 B:B:R197 14.53774.76NoNo055
245B:B:L210 B:B:R219 72.68682.43YesNo055
246B:B:D212 B:B:R219 58.14955.96NoNo095
247B:B:D212 B:B:E215 43.61215.2NoNo093
248B:B:E215 B:B:M217 29.07485.41NoNo033
249B:B:I273 B:B:Y289 16.999.67YesYes067
250B:B:I269 B:B:Y289 12.13526.04NoYes047
251B:B:N295 B:B:Y289 12.134510.47YesYes667
252B:B:E10 G:G:V16 19.38422.85NoNo087
253B:B:A11 G:G:V16 14.53811.7NoNo057
254R:R:W674 W:W:?1 1004.16YesYes390
255R:R:W674 R:R:Y707 1007.72YesYes399
256R:R:S670 R:R:Y707 1003.82NoYes089
257R:R:P710 R:R:S670 1003.56NoNo098
258R:R:L669 R:R:P710 1003.28YesNo099
259R:R:H665 R:R:L669 1009YesYes099
260R:R:H665 R:R:L735 1003.86YesYes099
261R:R:L735 R:R:L744 57.48424.15YesYes998
262R:R:L744 R:R:W737 44.13136.83YesNo086
263R:R:P575 R:R:W737 40.119620.27YesNo066
264R:R:P575 R:R:S574 36.11333.56YesYes1169
265R:R:L705 R:R:M677 1005.65NoYes066
266R:R:F673 R:R:L705 1006.09NoNo086
267R:R:F673 R:R:P710 10011.56NoNo089
268R:R:S574 R:R:V577 16.05063.23YesYes1193
269R:R:F747 R:R:H665 1006.79YesYes089
270R:R:F747 R:R:L572 18.72513.65YesYes989
271R:R:F569 R:R:L572 16.05046.09YesYes999
272R:R:F569 R:R:T589 12.03916.49YesNo099
273R:R:F747 R:R:Y668 32.09884.13YesYes988
274R:R:D638 R:R:Y668 28.09664.6YesYes078
275R:R:H820 R:R:S574 14.7134.18YesYes1189
276R:R:L744 R:R:V748 12.03484.47YesNo087
277R:R:F672 R:R:F747 44.12637.5YesYes098
278R:R:A751 R:R:F672 22.73435.55NoYes099
279R:R:F823 R:R:M573 13.37127.46NoYes099
280R:R:F672 R:R:W804 14.710616.04YesYes099
281R:R:P578 R:R:V577 13.37563.53YesYes043
282R:R:H820 R:R:P578 13.37564.58YesYes084
283R:R:I581 R:R:P578 21.40116.77YesYes044
284R:R:T589 R:R:Y590 10.70152.5NoYes095
285R:R:P798 R:R:T797 17.38883.5NoNo099
286R:R:F833 R:R:P798 16.05132.89NoNo079
287R:R:F832 R:R:F833 14.71376.43NoNo057
288R:R:D638 R:R:S596 12.04364.42YesNo079
289R:R:G831 R:R:S596 10.70553.71NoNo099
290R:R:D638 R:R:L634 13.38028.14YesNo079
291R:R:L600 R:R:L634 12.04374.15NoNo099
292R:R:H665 R:R:S714 32.09684.18YesNo099
293R:R:F666 R:R:S714 13.37299.25NoNo079
294R:R:F662 R:R:S714 17.38933.96NoNo089
295R:R:F662 R:R:F663 16.05185.36NoNo088
296R:R:F663 R:R:W640 14.714216.04NoNo086
297R:R:A660 R:R:W640 12.0392.59NoNo076
298R:R:A660 R:R:G644 10.70141.95NoNo076
299R:R:H665 R:R:T717 30.75015.48YesNo099
300R:R:T717 R:R:Y727 29.41324.99NoYes099
301R:R:V661 R:R:Y727 24.07356.31NoYes089
302R:R:K728 R:R:V661 21.39873.04YesNo058
303R:R:L735 R:R:Y727 29.43195.86YesYes999
304R:R:T721 R:R:Y727 24.07353.75YesYes099
305R:R:L735 R:R:P743 13.3783.28YesNo098
306R:R:P743 R:R:T721 12.040312.24NoYes089
307R:R:S741 R:R:T721 28.08853.2NoYes089
308R:R:S741 R:R:T726 24.07593.2NoYes084
309R:R:S738 R:R:T726 12.0383.2NoYes024
310R:R:A751 R:R:L752 12.04121.58NoNo098
311R:R:I808 R:R:L752 10.70344.28NoNo078
312R:R:F806 R:R:F823 16.04334.29NoNo089
313B:B:M217 G:G:M21 14.53741.44NoNo031
314A:A:E289 A:A:Q288 10.68761.27NoNo065
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


2D representation of the interactions of this orthosteric/allosteric ligand.


Links and nodes colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:L681 R:R:T622 7.37 0 No No 7 7 2 1
R:R:T622 W:W:?1 5.39 0 No Yes 7 0 1 0
R:R:I625 R:R:M699 4.37 0 No No 7 7 1 2
R:R:I625 W:W:?1 5.22 0 No Yes 7 0 1 0
R:R:C626 R:R:L678 3.17 0 No No 7 8 1 2
R:R:C626 W:W:?1 4.35 0 No Yes 7 0 1 0
R:R:N629 R:R:W674 25.99 3 No Yes 9 9 2 1
R:R:F703 R:R:N629 8.46 3 Yes No 8 9 2 2
R:R:N629 R:R:Y707 4.65 3 No Yes 9 9 2 2
R:R:M677 R:R:W674 4.65 3 Yes Yes 6 9 1 1
R:R:F703 R:R:W674 8.02 3 Yes Yes 8 9 2 1
R:R:G706 R:R:W674 4.22 0 No Yes 9 9 2 1
R:R:W674 R:R:Y707 7.72 3 Yes Yes 9 9 1 2
R:R:W674 W:W:?1 4.16 3 Yes Yes 9 0 1 0
R:R:L676 R:R:M677 4.24 0 Yes Yes 7 6 2 1
R:R:I680 R:R:L676 4.28 0 No Yes 8 7 1 2
R:R:G702 R:R:M677 3.49 3 No Yes 7 6 1 1
R:R:L705 R:R:M677 5.65 0 No Yes 6 6 2 1
R:R:M677 W:W:?1 9.04 3 Yes Yes 6 0 1 0
R:R:I680 W:W:?1 6.52 0 No Yes 8 0 1 0
R:R:A683 R:R:V761 3.39 0 No No 6 8 1 2
R:R:L688 R:R:Y684 7.03 3 No Yes 6 8 1 2
R:R:H691 R:R:Y684 6.53 3 Yes Yes 7 8 1 2
R:R:M693 R:R:Y684 7.18 3 No Yes 5 8 1 2
R:R:I687 R:R:L764 4.28 0 No No 6 7 1 2
R:R:I687 W:W:?1 10.44 0 No Yes 6 0 1 0
R:R:H691 R:R:L688 6.43 3 Yes No 7 6 1 1
R:R:L688 W:W:?1 10.12 3 No Yes 6 0 1 0
R:R:H691 R:R:M693 9.19 3 Yes No 7 5 1 1
R:R:H691 W:W:?1 5.87 3 Yes Yes 7 0 1 0
R:R:M693 W:W:?1 3.88 3 No Yes 5 0 1 0
R:R:F703 R:R:M699 6.22 3 Yes No 8 7 2 2
R:R:G702 W:W:?1 6.25 3 No Yes 7 0 1 0
R:R:F703 R:R:Y707 3.09 3 Yes Yes 8 9 2 2
R:R:A683 W:W:?1 2.88 0 No Yes 6 0 1 0
R:R:V701 W:W:?1 2.72 0 No Yes 6 0 1 0

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

ShowSimilarityNetwork TypeNameLigandDescription
56.25Single7WU4K6G7WU4-ADGRF1-K6G-Gi1/&β;1/&γ;2
46.67Single7WU3K6G7WU3-ADGRF1-K6G-Gs/&β;1/&γ;2
40.00Single8G2YLPC8G2Y-ADGRF1-LPC-chim(Gs-CtGq)/&β;1/&γ;2
21.43Single5XSZGlyceryl Mono-oleate5XSZ-LPA6-Glyceryl Mono-oleate
20.00Single5KW2PubChem 1330539535KW2-FFA1 (GPR40)-PubChem 133053953
17.39Single5TZYMK8666; PubChem 1270535975TZY-FFA1 (GPR40)-MK8666; PubChem 127053597
15.79Single6N48PubChem 1384542566N48-β2-BI167107-PubChem 138454256
15.00Single6C1RAvacopan; Na6C1R-C5a1-PMX53-Avacopan; Na
15.00Consensusc5a1_off_ortoalloOther Ligand6C1Q-C5a1-PMX53-NDT9513727 6C1R-C5a1-PMX53-Avacopan; Na
12.50Single8U4PCholesterol8U4P-CXCR4-AMD3100-Cholesterol-Gi1/&β;1/&γ;2
11.11Single7CKZMevidalen7CKZ-D1-Dopamine-Mevidalen-Gs/&β;1/&γ;2
11.11Single7LJDMevidalen7LJD-D1-Dopamine-Mevidalen-Gs/&β;1/&γ;1
11.11Single7SHFPI; PE7SHF-GPR158-PI; PE-B5; RGS7
11.11Single7X2FMevidalen7X2F-D1-Dopamine-Mevidalen-Gs/&β;1/&γ;2
11.11Single8U4QCholesterol8U4Q-CXCR4-REGN7663-Fab-Cholesterol-Gi1/&β;1/&γ;2
10.53Single7LJCMevidalen7LJC-D1-PubChem 86764103-Mevidalen-Gs/&β;1/&γ;2
10.53Consensusd1_on_alloOther Ligand7LJC-D1-PubChem 86764103-Mevidalen-Gs/&β;1/&γ;2 7CKZ-D1-Dopamine-Mevidalen-Gs/&β;1/&γ;2
10.00Single5O9HNDT95137275O9H-C5a1-NDT9513727
9.52Consensusadgrf1_on_alloOther Ligand7WU5-ADGRF1-K6G-Gi1/&β;1/&γ;2 8G2Y-ADGRF1-LPC-chim(Gs-CtGq)/&β;1/&γ;2
8.33Single7SHEPI; PE7SHE-GPR158-PI; PE
8.00Single7SHFPI; PE7SHF-GPR158-PI; PE-B5; RGS7
7.14Single7SHEPI; PE7SHE-GPR158-PI; PE
6.67Single4PXFOctyl Beta-D-Glucopyranoside4PXF-Rhodopsin-Octyl Beta-D-Glucopyranoside-Arrestin1_Finger_loop
6.25Single8U4NCholesterol8U4N-CXCR4-Cholesterol-Gi1/&β;1/&γ;2
5.88Single6KQIORG275696KQI-CB1-PubMed 104895-ORG27569
5.88Consensuscb1_off_alloOther Ligand6KQI-CB1-PubMed 104895-ORG27569
5.56Single6OBAGTPL110746OBA-β2-(S)-Alprenolol-GTPL11074
5.56Single8U4OCholesterol8U4O-CXCR4-CXCL12-Cholesterol-Gi1/&β;1/&γ;2
5.56Single8U4RCholesterol8U4R-CXCR4-REGN7663-Fab-Cholesterol
5.56Single8WG8Peptide8WG8-Glucagon-Peptide-chim(NtGi1-Gs)/&β;1/&γ;2
5.56Consensusbeta2_off_alloOther Ligand6OBA-β2-(S)-Alprenolol-GTPL11074
5.00Single6C1QNDT95137276C1Q-C5a1-PMX53-NDT9513727
5.00Single8G94CD698G94-S1P1-CD69-Gi1/&β;1/&γ;2
4.76Single8IYXYL-3658IYX-GPR34-YL-365
2.44Consensusct_onOrthosteric Ligand7TYL-CT-Amylin-Gs/&β;1/&γ;2 7TYN-CT-Calcitonin-1-Gs/&β;1/&γ;2 8F0J-CT-Pramlintide analogue san45-Gs/&β;1/&γ;2 6NIY-CT-Adrenomedullin-Gs/&β;1/&γ;2

PDB Summary
PDB 7WU5
Class B2
SubFamily Adhesion
Type Adhesion
SubType ADGRF1
Species Homo sapiens
Ligand -
Other Ligand(s) K6G
Protein Partners Gi1/Beta1/Gamma2
PDB Resolution 3
Date 2022-04-27
D.O.I. 10.1038/s41586-022-04580-w
Net Summary
Imin 3.04
Number of Linked Nodes 851
Number of Links 1050
Number of Hubs 164
Number of Links mediated by Hubs 608
Number of Communities 24
Number of Nodes involved in Communities 234
Number of Links involved in Communities 353
Path Summary
Number Of Nodes in MetaPath 315
Number Of Links MetaPath 314
Number of Shortest Paths 142208846
Length Of Smallest Path 3
Average Path Length 128
Length of Longest Path 96
Minimum Path Strength 1.46
Average Path Strength 8.02572
Maximum Path Strength 22.7367
Minimum Path Correlation 0.71
Average Path Correlation 1
Maximum Path Correlation 1
Minimum % Of Corr. Nodes 1.63934
Average % Of Corr. Nodes 64.7746
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 64.2557
Maximum Path Hubs % 100
AnnotationTypeLinks
Gene OntologyMolecular Function
Gene OntologyBiological Process
Gene OntologyCellular Component
SCOP2Domain Identifier
SCOP2Family Identifier
Membrane Protein Annotations-• Orientations of Proteins in Membranes database (OPM)   • Protein Data Bank of Transmembrane Proteins (PDBTM)   • MemProtMD


Details about the values in these tables can be found in the corresponding documentation page .
CodeK6G
PDB ResiduesW:W:?1
Environment DetailsOpen EMBL-EBI Page
CodeK6G
Name[(2~{R})-2-oxidanyl-3-[oxidanyl-[2-(trimethyl-$l^{4}-azanyl)ethoxy]phosphoryl]oxy-propyl] hexadecanoate
Synonyms
Identifier[(2~{R})-2-oxidanyl-3-[oxidanyl-[2-(trimethyl-$l^{4}-azanyl)ethoxy]phosphoryl]oxy-propyl] hexadecanoate
FormulaC24 H51 N O7 P
Molecular Weight496.638
SMILESCCCCCCCCCCCCCCCC(=O)OC[C@H](COP(=O)(O)OCC[N](C)(C)C)O
PubChem
Formal Charge0
Total Atoms84
Total Chiral Atoms1
Total Bonds83
Total Aromatic Bonds0

PDBsumOpen PDBsum Page
ChainA
ProteinG Protein α Sub unit
UniProtP63096
Sequence
>7WU5_Chain_A
KAAVERSKM IDRNLREDG EKAAREVKL LLLGADNSG KSTIVKQMT 
GIVETHFTF KDLHFKMFD VGGQRSERK KWIHCFEDV AAIIFCVDL 
SDYNRMHES MKLFDSICN NKWFTDTSI ILFLNKKDL FEEKIKKSP 
LTICYQEYA GSNTYEEAA AYIQCQFED LNKRKDTKE IYTHFTCAT 
DTKNAQFIF DAVTDVIIK NNLKDCGLF


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainB
ProteinG Protein β Sub unit
UniProtP62873
Sequence
>7WU5_Chain_B
SELDQLRQE AEQLKNQIR DARKACADA TLSQITNNI DPVGRIQMR 
TRRTLRGHL AKIYAMHWG TDSRLLVSA SQDGKLIIW DSYTTNKVH 
AIPLRSSWV MTCAYAPSG NYVACGGLD NICSIYNLK TREGNVRVS 
RELAGHTGY LSCCRFLDD NQIVTSSGD TTCALWDIE TGQQTTTFT 
GHTGDVMSL SLAPDTRLF VSGACDASA KLWDVREGM CRQTFTGHE 
SDINAICFF PNGNAFATG SDDATCRLF DLRADQELM TYSHDNIIC 
GITSVSFSK SGRLLLAGY DDFNCNVWD ALKADRAGV LAGHDNRVS 
CLGVTDDGM AVATGSWDS FLKIWN


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainG
ProteinG Protein γ Sub unit
UniProtP59768
Sequence
>7WU5_Chain_G
ASIAQARKL VEQLKMEAN IDRIKVSKA AADLMAYCE AHAKEDPLL 
TPVPASENP FR


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainR
ProteinReceptor
UniProtQ5T601
Sequence
>7WU5_Chain_R
ASFSILMSP FVPSTIFPV VKWITYVGL GISIGSLIL CLIIEALFW 
KQIKKSQTS HTRRICMVN IALSLLIAD VWFIVGATV DTTVNPSGV 
CTAAVFFTH FFYLSLFFW MLMLGILLA YRIILVFHH MAQHLMMAV 
GFCLGYGCP LIISVITIA VTQPSNTYK RKDVCWLNW SNGSKPLLA 
FVVPALAIV AVNFVVVLL VLTKLWRPT VGERLSRDD KATIIRVGK 
SLLILTPLL GLTWGFGIG TIVDSQNLA WHVIFALLN AFQGFFILC 
FGILLDSKL RQLLFNK


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  



This network is also present in following consensuses:
IdComponents
adgrf1_on_allo7WU5-ADGRF1-K6G-Gi1/&β;1/&γ;2
8G2Y-ADGRF1-LPC-chim(Gs-CtGq)/&β;1/&γ;2

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
7WU3B2AdhesionAdhesionADGRF1Homo sapiens-K6GGs/&β;1/&γ;23.12022-04-2710.1038/s41586-022-04580-w
7WU4B2AdhesionAdhesionADGRF1Homo sapiens-K6GGi1/&β;1/&γ;23.42022-04-2710.1038/s41586-022-04580-w
7WU5B2AdhesionAdhesionADGRF1Homo sapiens-K6GGi1/&β;1/&γ;232022-04-2710.1038/s41586-022-04580-w
7WXUB2AdhesionAdhesionADGRF1Homo sapiens--chim(NtGi1-Gs-CtGq)/&β;1/&γ;22.852022-09-2810.1038/s41467-022-33173-4
7WXWB2AdhesionAdhesionADGRF1Homo sapiens--chim(NtGi1-Gs)/&β;1/&γ;22.842022-09-2810.1038/s41467-022-33173-4
7WY0B2AdhesionAdhesionADGRF1Homo sapiens--chim(NtGi1L-G13)/&β;1/&γ;22.832022-09-2810.1038/s41467-022-33173-4
7WZ7B2AdhesionAdhesionADGRF1Homo sapiens--chim(NtGi1-G12)/&β;1/&γ;22.832022-09-2810.1038/s41467-022-33173-4
7X2VB2AdhesionAdhesionADGRF1Homo sapiens--Gi1/&β;1/&γ;23.092022-09-2810.1038/s41467-022-33173-4
8G2YB2AdhesionAdhesionADGRF1Homo sapiens-LPCchim(Gs-CtGq)/&β;1/&γ;23.442023-05-1010.1038/s41467-023-38083-7




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