psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:S568	R:R:V577	3.23	No	No	0	9	3
2	R:R:S568	R:R:V585	3.23	No	No	0	9	8
3	R:R:F569	R:R:T589	7.78	Yes	No	2	9	9
4	R:R:F569	R:R:L593	6.09	Yes	Yes	2	9	8
5	R:R:F569	R:R:Y668	3.09	Yes	Yes	2	9	8
6	R:R:F569	R:R:W804	3.01	Yes	Yes	2	9	9
7	R:R:F569	R:R:F823	3.22	Yes	Yes	2	9	9
8	R:R:F569	R:R:N827	3.62	Yes	Yes	2	9	9
9	R:R:S570	R:R:T810	3.2	No	Yes	2	9	7
10	R:R:H820	R:R:S570	13.95	Yes	No	2	8	9
11	R:R:I571	R:R:V577	4.61	No	No	0	7	3
12	R:R:F641	R:R:I571	5.02	No	No	0	9	7
13	R:R:F641	R:R:L572	3.65	No	No	0	9	9
14	R:R:L572	R:R:Y668	8.21	No	Yes	0	9	8
15	R:R:G807	R:R:M573	5.24	No	No	2	9	9
16	R:R:M573	R:R:T810	4.52	No	Yes	2	9	7
17	R:R:F823	R:R:M573	4.98	Yes	No	2	9	9
18	R:R:P575	R:R:S574	3.56	No	Yes	0	6	9
19	R:R:S574	R:R:T810	4.8	Yes	Yes	0	9	7
20	R:R:I811	R:R:S574	4.64	No	Yes	0	5	9
21	R:R:S574	R:R:S814	3.26	Yes	No	0	9	5
22	R:R:P575	R:R:W737	12.16	No	Yes	0	6	6
23	R:R:F576	R:R:S814	9.25	No	No	0	3	5
24	R:R:P578	R:R:T580	3.5	No	No	0	4	3
25	R:R:H820	R:R:P578	6.1	Yes	No	0	8	4
26	R:R:I581	R:R:T580	4.56	Yes	No	5	4	3
27	R:R:L817	R:R:T580	11.79	No	No	5	2	3
28	R:R:I581	R:R:V584	3.07	Yes	No	0	4	3
29	R:R:I581	R:R:L817	4.28	Yes	No	5	4	2
30	R:R:F582	R:R:K586	9.93	No	No	0	1	3
31	R:R:K586	R:R:P583	6.69	No	No	0	3	1
32	R:R:I588	R:R:L825	8.56	No	No	0	9	5
33	R:R:L593	R:R:T589	2.95	Yes	No	2	8	9
34	R:R:F829	R:R:G592	6.02	Yes	No	0	7	9
35	R:R:D638	R:R:L593	4.07	Yes	Yes	0	7	8
36	R:R:I642	R:R:L593	4.28	No	Yes	0	8	8
37	R:R:F829	R:R:I595	3.77	Yes	No	0	7	7
38	R:R:G831	R:R:S596	3.71	No	No	0	9	9
39	R:R:I597	R:R:L635	4.28	Yes	No	0	7	8
40	R:R:D638	R:R:I597	2.8	Yes	Yes	0	7	7
41	R:R:I597	R:R:V639	3.07	Yes	No	0	7	6
42	R:R:G598	R:R:I601	3.53	No	No	0	3	5
43	R:R:F832	R:R:S599	2.64	Yes	No	0	5	8
44	R:R:L835	R:R:S599	9.01	No	No	0	8	8
45	R:R:L600	R:R:L634	5.54	No	Yes	0	9	9
46	R:R:L600	R:R:L635	2.77	No	No	0	9	8
47	R:R:G831	R:R:L600	5.13	No	No	0	9	9
48	R:R:I601	R:R:I605	2.94	No	No	0	5	6
49	R:R:I601	R:R:L635	2.85	No	No	0	5	8
50	R:R:L602	R:R:L835	4.15	No	No	0	6	8
51	R:R:C603	R:R:E607	6.08	No	No	0	7	9
52	R:R:L604	R:R:L632	6.92	No	No	0	8	5
53	R:R:I606	R:R:I839	2.94	No	No	0	8	7
54	R:R:E607	R:R:R624	5.82	No	Yes	0	9	9
55	R:R:E607	R:R:M627	6.77	No	No	0	9	7
56	R:R:F610	R:R:R624	6.41	No	Yes	0	8	9
57	R:R:H621	R:R:W611	3.17	No	No	0	6	9
58	R:R:Q618	R:R:T619	2.83	No	No	0	7	8
59	R:R:R685	R:R:T619	19.41	No	No	0	8	8
60	R:R:H621	R:R:I625	3.98	No	No	1	6	7
61	R:R:H621	R:R:M699	2.63	No	No	1	6	7
62	R:R:L681	R:R:T622	2.95	No	No	0	7	7
63	R:R:M698	R:R:T622	3.01	Yes	No	0	8	7
64	R:R:R623	R:R:R624	4.26	No	Yes	0	9	9
65	R:R:R624	R:R:V628	2.62	Yes	No	0	9	7
66	R:R:I625	R:R:M699	2.92	No	No	1	7	7
67	R:R:I625	W:W:?1	3.47	No	Yes	1	7	0
68	R:R:C626	R:R:L678	3.17	No	No	0	7	8
69	R:R:L799	R:R:M627	7.07	Yes	No	0	6	7
70	R:R:N629	R:R:V628	2.96	No	No	0	9	7
71	R:R:N629	R:R:W674	18.08	No	Yes	1	9	9
72	R:R:F703	R:R:N629	3.62	No	No	1	8	9
73	R:R:I630	R:R:L671	2.85	No	Yes	6	8	7
74	R:R:I630	R:R:M675	5.83	No	Yes	6	8	9
75	R:R:I630	R:R:L799	2.85	No	Yes	0	8	6
76	R:R:S633	R:R:S670	4.89	No	No	0	8	8
77	R:R:L671	R:R:S633	4.5	Yes	No	0	7	8
78	R:R:D638	R:R:L634	6.79	Yes	Yes	0	7	9
79	R:R:L634	R:R:L671	5.54	Yes	Yes	0	9	7
80	R:R:L634	R:R:Q830	5.32	Yes	No	0	9	9
81	R:R:F667	R:R:I636	18.84	No	No	0	8	7
82	R:R:A637	R:R:Y668	9.34	No	Yes	0	9	8
83	R:R:D638	R:R:Y668	3.45	Yes	Yes	0	7	8
84	R:R:V643	R:R:W640	3.68	No	No	0	8	6
85	R:R:A660	R:R:W640	3.89	No	No	0	7	6
86	R:R:F663	R:R:W640	18.04	No	No	0	8	6
87	R:R:C657	R:R:K728	3.23	No	No	0	9	5
88	R:R:C657	R:R:C733	7.28	No	No	0	9	9
89	R:R:V661	R:R:Y727	5.05	No	Yes	0	8	9
90	R:R:F662	R:R:F663	7.5	No	No	0	8	8
91	R:R:F662	R:R:S714	6.61	No	No	0	8	9
92	R:R:F663	R:R:F667	4.29	No	No	0	8	8
93	R:R:T664	R:R:W734	3.64	No	No	0	7	8
94	R:R:H665	R:R:L669	5.14	Yes	Yes	3	9	9
95	R:R:H665	R:R:T717	2.74	Yes	No	0	9	9
96	R:R:H665	R:R:L735	3.86	Yes	Yes	0	9	9
97	R:R:F747	R:R:H665	7.92	No	Yes	3	8	9
98	R:R:F666	R:R:F667	6.43	Yes	No	0	7	8
99	R:R:F666	R:R:P710	2.89	Yes	Yes	0	7	9
100	R:R:F666	R:R:L711	8.53	Yes	No	0	7	7
101	R:R:F666	R:R:S714	3.96	Yes	No	0	7	9
102	R:R:W804	R:R:Y668	4.82	Yes	Yes	2	9	8
103	R:R:L669	R:R:P710	3.28	Yes	Yes	3	9	9
104	R:R:F747	R:R:L669	3.65	No	Yes	3	8	9
105	R:R:L669	R:R:P750	3.28	Yes	No	0	9	9
106	R:R:P710	R:R:S670	3.56	Yes	No	0	9	8
107	R:R:F672	R:R:L671	4.87	No	Yes	0	9	7
108	R:R:L671	R:R:M675	2.83	Yes	Yes	6	7	9
109	R:R:A751	R:R:F672	4.16	No	No	0	9	9
110	R:R:F672	R:R:W804	19.04	No	Yes	0	9	9
111	R:R:C709	R:R:F673	5.59	No	No	3	8	8
112	R:R:F673	R:R:P710	10.11	No	Yes	3	8	9
113	R:R:F673	R:R:I754	3.77	No	No	0	8	9
114	R:R:G702	R:R:W674	2.81	Yes	Yes	1	7	9
115	R:R:F703	R:R:W674	3.01	No	Yes	1	8	9
116	R:R:G706	R:R:W674	4.22	No	Yes	0	9	9
117	R:R:W674	R:R:Y707	7.72	Yes	No	1	9	9
118	R:R:M675	R:R:N758	4.21	Yes	No	0	9	9
119	R:R:G801	R:R:M675	3.49	No	Yes	0	9	9
120	R:R:I754	R:R:L676	4.28	No	No	0	9	7
121	R:R:G702	R:R:M677	5.24	Yes	No	1	7	6
122	R:R:L705	R:R:M677	5.65	No	No	0	6	6
123	R:R:M677	W:W:?1	9.16	No	Yes	1	6	0
124	R:R:L678	R:R:L799	4.15	No	Yes	0	8	6
125	R:R:I680	W:W:?1	15.03	No	Yes	0	8	0
126	R:R:L681	R:R:R685	6.07	No	No	0	7	8
127	R:R:L681	W:W:?1	8.97	No	Yes	0	7	0
128	R:R:I686	R:R:L682	2.85	Yes	No	8	7	9
129	R:R:L682	R:R:V765	4.47	No	No	8	9	9
130	R:R:A683	R:R:V761	3.39	No	No	0	6	8
131	R:R:L688	R:R:Y684	5.86	Yes	Yes	1	6	8
132	R:R:M693	R:R:Y684	9.58	No	Yes	1	5	8
133	R:R:M698	R:R:Y684	4.79	Yes	Yes	1	8	8
134	R:R:Y684	W:W:?1	2.85	Yes	Yes	1	8	0
135	R:R:I686	R:R:V765	4.61	Yes	No	8	7	9
136	R:R:I686	R:R:K768	2.91	Yes	No	0	7	8
137	R:R:I687	R:R:L764	7.14	No	No	0	6	7
138	R:R:L688	W:W:?1	3.36	Yes	Yes	1	6	0
139	R:R:F690	R:R:V689	2.62	No	No	0	8	9
140	R:R:M693	R:R:M698	2.89	No	Yes	1	5	8
141	R:R:H696	R:R:Q695	11.13	No	No	0	5	6
142	R:R:M699	R:R:Q695	4.08	No	No	0	7	6
143	R:R:L697	R:R:V701	2.98	No	No	0	3	6
144	R:R:M698	W:W:?1	9.16	Yes	Yes	1	8	0
145	R:R:G702	W:W:?1	2.77	Yes	Yes	1	7	0
146	R:R:F703	R:R:Y707	3.09	No	No	1	8	9
147	R:R:C709	R:R:P710	3.77	No	Yes	3	8	9
148	R:R:S714	R:R:V715	3.23	No	No	0	9	6
149	R:R:P743	R:R:T717	5.25	Yes	No	0	8	9
150	R:R:I718	R:R:Y727	13.3	No	Yes	0	7	9
151	R:R:Q722	R:R:T721	2.83	No	No	7	7	9
152	R:R:T721	R:R:Y727	6.24	No	Yes	7	9	9
153	R:R:Q722	R:R:Y727	5.64	No	Yes	7	7	9
154	R:R:R729	R:R:V732	5.23	No	No	0	5	4
155	R:R:N736	R:R:R729	7.23	No	No	0	8	5
156	R:R:D731	R:R:K730	5.53	No	No	0	3	2
157	R:R:L735	R:R:W734	13.67	Yes	No	0	9	8
158	R:R:F747	R:R:W734	9.02	No	No	0	8	8
159	R:R:L735	R:R:P743	6.57	Yes	Yes	0	9	8
160	R:R:L735	R:R:L744	4.15	Yes	No	0	9	8
161	R:R:N736	R:R:N739	12.26	No	No	0	8	4
162	R:R:G740	R:R:N736	5.09	No	No	0	4	8
163	R:R:S741	R:R:W737	6.18	No	Yes	0	8	6
164	R:R:L744	R:R:W737	6.83	No	Yes	0	8	6
165	R:R:L745	R:R:W737	3.42	No	Yes	0	8	6
166	R:R:I811	R:R:W737	3.52	No	Yes	0	5	6
167	R:R:G740	R:R:P743	6.09	No	Yes	0	4	8
168	R:R:K742	R:R:P743	3.35	No	Yes	0	7	8
169	R:R:L744	R:R:V748	2.98	No	No	0	8	7
170	R:R:L752	R:R:V748	4.47	No	No	0	8	7
171	R:R:I811	R:R:V748	3.07	No	No	0	5	7
172	R:R:P750	R:R:V749	5.3	No	No	0	9	7
173	R:R:I808	R:R:L752	5.71	No	No	0	7	8
174	R:R:I754	R:R:N758	4.25	No	No	0	9	9
175	R:R:G805	R:R:V755	3.68	No	No	0	6	8
176	R:R:L800	R:R:N758	8.24	Yes	No	0	9	9
177	R:R:L802	R:R:V762	4.47	No	No	0	7	8
178	R:R:L766	R:R:V789	2.98	No	No	0	7	8
179	R:R:L766	R:R:S792	4.5	No	No	0	7	8
180	R:R:L769	R:R:S792	3	No	No	0	7	8
181	R:R:T785	R:R:W770	3.64	No	No	0	7	6
182	R:R:R788	R:R:T785	15.52	No	No	0	7	7
183	R:R:K791	R:R:L841	2.82	No	No	0	8	5
184	R:R:L793	R:R:T797	2.95	No	No	0	7	9
185	R:R:F837	R:R:L794	12.18	No	No	0	8	6
186	R:R:L794	R:R:L841	4.15	No	No	0	6	5
187	R:R:G838	R:R:I795	3.53	No	No	0	8	7
188	R:R:P798	R:R:T797	3.5	Yes	No	0	9	9
189	R:R:F833	R:R:P798	2.89	Yes	Yes	4	7	9
190	R:R:F837	R:R:P798	2.89	No	Yes	4	8	9
191	R:R:L799	R:R:L800	2.77	Yes	Yes	0	6	9
192	R:R:L826	R:R:T803	8.84	No	No	0	6	9
193	R:R:N827	R:R:T803	4.39	Yes	No	0	9	9
194	R:R:F823	R:R:W804	4.01	Yes	Yes	2	9	9
195	R:R:N827	R:R:W804	15.82	Yes	Yes	2	9	9
196	R:R:Q830	R:R:W804	6.57	No	Yes	0	9	9
197	R:R:G807	R:R:T810	5.46	No	Yes	2	9	7
198	R:R:F823	R:R:G807	3.01	Yes	No	2	9	9
199	R:R:G809	R:R:I808	3.53	No	No	0	7	7
200	R:R:G809	R:R:W819	4.22	No	No	0	7	6
201	R:R:H820	R:R:T810	5.48	Yes	Yes	2	8	7
202	R:R:F823	R:R:T810	3.89	Yes	Yes	2	9	7
203	R:R:D813	R:R:V812	4.38	No	No	0	4	6
204	R:R:H820	R:R:S814	5.58	Yes	No	0	8	5
205	R:R:A818	R:R:N816	4.69	No	No	0	6	5
206	R:R:N816	R:R:W819	7.91	No	No	0	5	6
207	R:R:F823	R:R:N827	15.71	Yes	Yes	2	9	9
208	R:R:F829	R:R:L825	3.65	Yes	No	0	7	5
209	R:R:F829	R:R:F832	9.65	Yes	Yes	4	7	5
210	R:R:F829	R:R:F833	3.22	Yes	Yes	4	7	7
211	R:R:F832	R:R:F833	5.36	Yes	Yes	4	5	7
212	R:R:C836	R:R:F832	6.98	No	Yes	0	7	5
213	R:R:F833	R:R:F837	3.22	Yes	No	4	7	8
214	R:R:C836	R:R:L840	3.17	No	No	0	7	7
215	R:R:I839	R:R:L845	4.28	No	No	0	7	8
216	R:R:D842	R:R:K844	4.15	No	No	0	9	8
217	R:R:D842	R:R:L845	8.14	No	No	0	9	8
218	R:R:K844	R:R:L848	5.64	No	No	0	8	7
219	R:R:V591	R:R:W587	2.45	No	No	0	7	4
220	R:R:F610	R:R:L845	2.44	No	No	0	8	8
221	R:R:F806	R:R:L826	2.44	No	No	0	8	6
222	R:R:F833	R:R:L826	2.44	Yes	No	0	7	6
223	R:R:A828	R:R:G592	1.95	No	No	0	8	9
224	R:R:A660	R:R:G644	1.95	No	No	0	7	6
225	R:R:G592	R:R:V591	1.84	No	No	0	9	7
226	R:R:G644	R:R:V647	1.84	No	No	0	6	5
227	R:R:G679	R:R:V761	1.84	No	No	0	9	8
228	R:R:G702	R:R:V701	1.84	Yes	No	0	7	6
229	R:R:G790	R:R:V789	1.84	No	No	0	5	8
230	R:R:G809	R:R:V812	1.84	No	No	0	7	6
231	R:R:G655	R:R:T658	1.82	No	No	0	3	6
232	R:R:A631	R:R:C603	1.81	No	No	0	8	7
233	R:R:A660	R:R:C657	1.81	No	No	0	7	9
234	R:R:G594	R:R:I597	1.76	No	Yes	0	5	7
235	R:R:P743	R:R:T721	1.75	Yes	No	0	8	9
236	R:R:G679	R:R:L678	1.71	No	No	0	9	8
237	R:R:G679	R:R:L800	1.71	No	Yes	0	9	9
238	R:R:G708	R:R:L711	1.71	No	No	0	6	7
239	R:R:A824	R:R:V585	1.7	No	No	0	8	8
240	R:R:I581	R:R:P583	1.69	Yes	No	0	4	1
241	R:R:I834	R:R:P798	1.69	No	Yes	0	9	9
242	R:R:C709	R:R:I713	1.64	No	No	0	8	9
243	R:R:A631	R:R:L604	1.58	No	No	0	8	8
244	R:R:A608	R:R:L609	1.58	No	No	0	5	4
245	R:R:A694	R:R:L697	1.58	No	No	0	8	3
246	R:R:I588	R:R:V821	1.54	No	No	0	9	7
247	R:R:I716	R:R:V720	1.54	No	No	0	7	5
248	R:R:I822	R:R:V821	1.54	No	No	0	5	7
249	R:R:K586	R:R:T567	1.5	No	No	0	3	9
250	R:R:K728	R:R:T658	1.5	No	No	0	5	6
251	R:R:L676	R:R:V757	1.49	No	No	0	7	7
252	R:R:L766	R:R:V762	1.49	No	No	0	7	8
253	R:R:L800	R:R:V762	1.49	Yes	No	0	9	8
254	R:R:L796	R:R:V765	1.49	No	No	0	9	9
255	R:R:I686	R:R:I687	1.47	Yes	No	0	7	6
256	R:R:I787	R:R:K791	1.45	No	No	0	4	8
257	R:R:I687	R:R:L688	1.43	No	Yes	0	6	6
258	R:R:I795	R:R:L796	1.43	No	No	0	7	9
259	R:R:A645	R:R:F641	1.39	No	No	0	7	9
260	R:R:H691	R:R:L688	1.29	No	Yes	0	7	6
261	R:R:K730	R:R:R729	1.24	No	No	0	2	5
262	R:R:V755	R:R:W804	1.23	No	Yes	0	8	9
263	R:R:F759	R:R:L763	1.22	No	No	0	4	4
264	R:R:F759	R:R:L802	1.22	No	No	0	4	7
265	R:R:L769	R:R:R788	1.21	No	No	0	7	7

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	R:R:F569	4.46833	6	2	9
2	R:R:S574	4.065	4	0	9
3	R:R:I581	3.4	4	5	4
4	R:R:L593	4.3475	4	2	8
5	R:R:I597	2.9775	4	0	7
6	R:R:R624	4.7775	4	0	9
7	R:R:L634	5.7975	4	0	9
8	R:R:D638	4.2775	4	0	7
9	R:R:H665	4.915	4	3	9
10	R:R:F666	5.4525	4	0	7
11	R:R:Y668	5.782	5	2	8
12	R:R:L669	3.8375	4	3	9
13	R:R:L671	4.118	5	6	7
14	R:R:W674	7.168	5	1	9
15	R:R:M675	4.09	4	6	9
16	R:R:Y684	5.77	4	1	8
17	R:R:I686	2.96	4	8	7
18	R:R:L688	2.985	4	1	6
19	R:R:M698	4.9625	4	1	8
20	R:R:G702	3.165	4	1	7
21	R:R:P710	4.722	5	3	9
22	R:R:Y727	7.5575	4	7	9
23	R:R:L735	7.0625	4	0	9
24	R:R:W737	6.422	5	0	6
25	R:R:P743	4.602	5	0	8
26	R:R:P798	2.7425	4	4	9
27	R:R:L799	4.21	4	0	6
28	R:R:L800	3.5525	4	0	9
29	R:R:W804	7.78571	7	2	9
30	R:R:T810	4.55833	6	2	7
31	R:R:H820	7.7775	4	2	8
32	R:R:F823	5.80333	6	2	9
33	R:R:N827	9.885	4	2	9
34	R:R:F829	5.262	5	4	7
35	R:R:F832	6.1575	4	4	5
36	R:R:F833	3.426	5	4	7
37	W:W:?1	6.84625	8	1	0

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:F569	R:R:Y668	12.3902	3.09	Yes	Yes	2	9	8
2	R:R:L572	R:R:Y668	29.1387	8.21	No	Yes	0	9	8
3	R:R:F641	R:R:L572	25.9287	3.65	No	No	0	9	9
4	R:R:F641	R:R:I571	18.8378	5.02	No	No	0	9	7
5	R:R:I571	R:R:V577	15.102	4.61	No	No	0	7	3
6	R:R:S568	R:R:V577	11.3456	3.23	No	No	0	9	3
7	R:R:D638	R:R:Y668	18.2843	3.45	Yes	Yes	0	7	8
8	R:R:W804	R:R:Y668	21.854	4.82	Yes	Yes	2	9	8
9	R:R:F569	R:R:F823	13.0751	3.22	Yes	Yes	2	9	9
10	R:R:F823	R:R:W804	38.5472	4.01	Yes	Yes	2	9	9
11	R:R:N827	R:R:W804	34.0367	15.82	Yes	Yes	2	9	9
12	R:R:F823	R:R:T810	68.4677	3.89	Yes	Yes	2	9	7
13	R:R:H820	R:R:T810	24.981	5.48	Yes	Yes	2	8	7
14	R:R:P575	R:R:S574	18.8931	3.56	No	Yes	0	6	9
15	R:R:S574	R:R:T810	56.6378	4.8	Yes	Yes	0	9	7
16	R:R:I811	R:R:S574	43.6043	4.64	No	Yes	0	5	9
17	R:R:S574	R:R:S814	11.6984	3.26	Yes	No	0	9	5
18	R:R:P575	R:R:W737	17.8139	12.16	No	Yes	0	6	6
19	R:R:I811	R:R:W737	17.9108	3.52	No	Yes	0	5	6
20	R:R:H820	R:R:P578	26.2055	6.1	Yes	No	0	8	4
21	R:R:P578	R:R:T580	23.3483	3.5	No	No	0	4	3
22	R:R:I581	R:R:T580	17.551	4.56	Yes	No	5	4	3
23	R:R:I581	R:R:P583	11.7814	1.69	Yes	No	0	4	1
24	R:R:F829	R:R:F833	21.5081	3.22	Yes	Yes	4	7	7
25	R:R:F833	R:R:L826	53.1857	2.44	Yes	No	0	7	6
26	R:R:L826	R:R:T803	56.963	8.84	No	No	0	6	9
27	R:R:N827	R:R:T803	58.8309	4.39	Yes	No	0	9	9
28	R:R:L600	R:R:L634	12.1619	5.54	No	Yes	0	9	9
29	R:R:D638	R:R:L634	17.2466	6.79	Yes	Yes	0	7	9
30	R:R:D638	R:R:I597	14.6524	2.8	Yes	Yes	0	7	7
31	R:R:F832	R:R:F833	12.9021	5.36	Yes	Yes	4	5	7
32	R:R:E607	R:R:M627	98.6095	6.77	No	No	0	9	7
33	R:R:L799	R:R:M627	100	7.07	Yes	No	0	6	7
34	R:R:I630	R:R:L799	83.293	2.85	No	Yes	0	8	6
35	R:R:I630	R:R:L671	83.1131	2.85	No	Yes	6	8	7
36	R:R:L634	R:R:L671	27.2432	5.54	Yes	Yes	0	9	7
37	R:R:F672	R:R:L671	68.3224	4.87	No	Yes	0	9	7
38	R:R:F672	R:R:W804	67.1325	19.04	No	Yes	0	9	9
39	R:R:F610	R:R:L845	12.3072	2.44	No	No	0	8	8
40	R:R:F610	R:R:R624	14.3272	6.41	No	Yes	0	8	9
41	R:R:E607	R:R:R624	91.4009	5.82	No	Yes	0	9	9
42	R:R:I625	W:W:?1	12.5424	3.47	No	Yes	1	7	0
43	R:R:G702	W:W:?1	54.9844	2.77	Yes	Yes	1	7	0
44	R:R:G702	R:R:W674	65.7558	2.81	Yes	Yes	1	7	9
45	R:R:N629	R:R:W674	70.6814	18.08	No	Yes	1	9	9
46	R:R:N629	R:R:V628	75.9391	2.96	No	No	0	9	7
47	R:R:R624	R:R:V628	77.5649	2.62	Yes	No	0	9	7
48	R:R:L681	W:W:?1	10.2387	8.97	No	Yes	0	7	0
49	R:R:L671	R:R:M675	16.2504	2.83	Yes	Yes	6	7	9
50	R:R:L671	R:R:S633	48.3708	4.5	Yes	No	0	7	8
51	R:R:S633	R:R:S670	47.5337	4.89	No	No	0	8	8
52	R:R:F666	R:R:F667	27.6306	6.43	Yes	No	0	7	8
53	R:R:F666	R:R:P710	39.9516	2.89	Yes	Yes	0	7	9
54	R:R:P710	R:R:S670	46.8558	3.56	Yes	No	0	9	8
55	R:R:F663	R:R:F667	23.5213	4.29	No	No	0	8	8
56	R:R:F663	R:R:W640	21.6465	18.04	No	No	0	8	6
57	R:R:A660	R:R:W640	17.4265	3.89	No	No	0	7	6
58	R:R:A660	R:R:C657	10.9927	1.81	No	No	0	7	9
59	R:R:L744	R:R:W737	29.3947	6.83	No	Yes	0	8	6
60	R:R:L735	R:R:L744	45.8872	4.15	Yes	No	0	9	8
61	R:R:L735	R:R:P743	46.9872	6.57	Yes	Yes	0	9	8
62	R:R:P743	R:R:T721	23.3068	1.75	Yes	No	0	8	9
63	R:R:T721	R:R:Y727	14.0021	6.24	No	Yes	7	9	9
64	R:R:I811	R:R:V748	25.4099	3.07	No	No	0	5	7
65	R:R:L744	R:R:V748	18.4227	2.98	No	No	0	8	7
66	R:R:L669	R:R:P710	56.368	3.28	Yes	Yes	3	9	9
67	R:R:H665	R:R:L669	49.9965	5.14	Yes	Yes	3	9	9
68	R:R:H665	R:R:T717	21.4044	2.74	Yes	No	0	9	9
69	R:R:F673	R:R:P710	35.9875	10.11	No	Yes	3	8	9
70	R:R:F673	R:R:I754	37.0391	3.77	No	No	0	8	9
71	R:R:I754	R:R:N758	39.0937	4.25	No	No	0	9	9
72	R:R:M675	R:R:N758	15.0536	4.21	Yes	No	0	9	9
73	R:R:I686	R:R:I687	13.9744	1.47	Yes	No	0	7	6
74	R:R:I687	R:R:L688	17.8554	1.43	No	Yes	0	6	6
75	R:R:L688	W:W:?1	21.4666	3.36	Yes	Yes	1	6	0
76	R:R:L799	R:R:L800	43.0785	2.77	Yes	Yes	0	6	9
77	R:R:L800	R:R:N758	46.4338	8.24	Yes	No	0	9	9
78	R:R:N736	R:R:R729	18.6717	7.23	No	No	0	8	5
79	R:R:G740	R:R:N736	27.9281	5.09	No	No	0	4	8
80	R:R:G740	R:R:P743	32.5355	6.09	No	Yes	0	4	8
81	R:R:L752	R:R:V748	14.7146	4.47	No	No	0	8	7
82	R:R:I808	R:R:L752	12.9229	5.71	No	No	0	7	8
83	R:R:L800	R:R:V762	27.6721	1.49	Yes	No	0	9	8
84	R:R:L766	R:R:V762	18.6648	1.49	No	No	0	7	8
85	R:R:L766	R:R:S792	11.8229	4.5	No	No	0	7	8
86	R:R:F833	R:R:F837	10.3563	3.22	Yes	No	4	7	8
87	R:R:G809	R:R:I808	11.1173	3.53	No	No	0	7	7
88	R:R:P743	R:R:T717	20.1591	5.25	Yes	No	0	8	9
89	R:R:H665	R:R:L735	31.7468	3.86	Yes	Yes	0	9	9
90	R:R:F823	R:R:N827	20.4981	15.71	Yes	Yes	2	9	9

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:H621	R:R:I625	3.98	1	No	No	6	7	2	1
R:R:H621	R:R:M699	2.63	1	No	No	6	7	2	2
R:R:L681	R:R:T622	2.95	0	No	No	7	7	1	2
R:R:M698	R:R:T622	3.01	1	Yes	No	8	7	1	2
R:R:I625	R:R:M699	2.92	1	No	No	7	7	1	2
R:R:I625	W:W:?1	3.47	1	No	Yes	7	0	1	0
R:R:G702	R:R:W674	2.81	1	Yes	Yes	7	9	1	2
R:R:G702	R:R:M677	5.24	1	Yes	No	7	6	1	1
R:R:L705	R:R:M677	5.65	0	No	No	6	6	2	1
R:R:M677	W:W:?1	9.16	1	No	Yes	6	0	1	0
R:R:I680	W:W:?1	15.03	0	No	Yes	8	0	1	0
R:R:L681	R:R:R685	6.07	0	No	No	7	8	1	2
R:R:L681	W:W:?1	8.97	0	No	Yes	7	0	1	0
R:R:L688	R:R:Y684	5.86	1	Yes	Yes	6	8	1	1
R:R:M693	R:R:Y684	9.58	1	No	Yes	5	8	2	1
R:R:M698	R:R:Y684	4.79	1	Yes	Yes	8	8	1	1
R:R:Y684	W:W:?1	2.85	1	Yes	Yes	8	0	1	0
R:R:L688	W:W:?1	3.36	1	Yes	Yes	6	0	1	0
R:R:M693	R:R:M698	2.89	1	No	Yes	5	8	2	1
R:R:M698	W:W:?1	9.16	1	Yes	Yes	8	0	1	0
R:R:G702	W:W:?1	2.77	1	Yes	Yes	7	0	1	0
R:R:G702	R:R:V701	1.84	1	Yes	No	7	6	1	2
R:R:I687	R:R:L688	1.43	0	No	Yes	6	6	2	1
R:R:H691	R:R:L688	1.29	0	No	Yes	7	6	2	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	8G2Y_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	2.62
Number of Linked Nodes	230
Number of Links	265
Number of Hubs	37
Number of Links mediated by Hubs	134
Number of Communities	8
Number of Nodes involved in Communities	49
Number of Links involved in Communities	65

Path Summary
Number Of Nodes in MetaPath	91
Number Of Links MetaPath	90
Number of Shortest Paths	41102
Length Of Smallest Path	3
Average Path Length	13.7473
Length of Longest Path	31
Minimum Path Strength	1.22
Average Path Strength	5.28795
Maximum Path Strength	17.43
Minimum Path Correlation	0.7
Average Path Correlation	0.917162
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	3.84615
Average % Of Corr. Nodes	45.1642
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	45.2427
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process	• cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cell communication • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular process • signal transduction • cell surface receptor signaling pathway • regulation of lipid metabolic process • primary metabolic process • metabolic process • regulation of metabolic process • lipid metabolic process • regulation of primary metabolic process • developmental process • fat cell differentiation • cellular developmental process • cell differentiation • behavior • multicellular organismal process • system process • learning or memory • nervous system process • cognition • memory • nervous system development • cellular component organization • cellular component biogenesis • multicellular organism development • cell junction organization • cellular component assembly • cell junction assembly • anatomical structure development • synapse organization • cellular component organization or biogenesis • synapse assembly • system development • energy derivation by oxidation of organic compounds • energy reserve metabolic process • generation of precursor metabolites and energy • plasma membrane bounded cell projection organization • cell projection organization • cell development • neuron projection development • generation of neurons • neurogenesis • neuron differentiation • neuron development • membrane-bounded organelle • intracellular organelle • cellular anatomical structure • intracellular anatomical structure • cytoplasmic vesicle • organelle • intracellular vesicle • cytoplasm • intracellular membrane-bounded organelle • vesicle • membrane • extracellular region • cell periphery • plasma membrane • protein binding • binding • G-protein beta-subunit binding • fibroblast proliferation • cell population proliferation • cellular response to nitrogen compound • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • response to oxygen-containing compound • response to nitrogen compound • cellular response to oxygen-containing compound • cellular response to chemical stimulus • cellular response to monoamine stimulus • response to chemical • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to alcohol • response to hormone • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • extracellular vesicle • extracellular organelle • extracellular space • extracellular membrane-bounded organelle • synapse • cell junction • enzyme binding • GTPase binding • protein-containing complex binding • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • sensory perception of chemical stimulus • sensory perception • sensory perception of taste • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • camera-type eye development • sensory system development • small GTPase-mediated signal transduction • Ras protein signal transduction • intracellular signal transduction • intracellular signaling cassette • phospholipase C-activating G protein-coupled receptor signaling pathway • synaptic signaling • cellular response to acetylcholine • cell-cell signaling • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • non-motile cilium • 9+0 non-motile cilium • cilium • neuron projection • photoreceptor disc membrane • photoreceptor outer segment • plasma membrane bounded cell projection • cell projection • photoreceptor cell cilium • organelle membrane • cytosol • vacuolar membrane • lytic vacuole • vacuole • lytic vacuole membrane • bounding membrane of organelle • lysosomal membrane • lysosome
Gene Ontology	Cellular Component
SCOP2	Domain Identifier
SCOP2	Family Identifier
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	LPC
PDB Residues	W:W:?1
Environment Details	Open EMBL-EBI Page
Code	LPC
Name	[1-MYRISTOYL-GLYCEROL-3-YL]PHOSPHONYLCHOLINE
Synonyms
Identifier
Formula	C22 H47 N O7 P
Molecular Weight	468.585
SMILES
PubChem	444675
Formal Charge	1
Total Atoms	78
Total Chiral Atoms	2
Total Bonds	77
Total Aromatic Bonds	0


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	Q5T601
Sequence	>8G2Y_nogp_Chain_R T S F S I L M S P F V P S T I F P V V K W I T Y V G L G I S I G S L I L C L I I E A L F W Q T S H T R R I C M V N I A L S L L I A D V W F I V G A T V G V C T A A V F F T H F F Y L S L F F W M L M L G I L L A Y R I I L V F H H M A Q H L M M A V G F C L G Y G C P L I I S V I T I A V T Q Y K R K D V C W L N W S N G S K P L L A F V V P A L A I V A V N F V V V L L V L T K L W T I I R V G K S L L I L T P L L G L T W G F G I G T I V D S Q N L A W H V I F A L L N A F Q G F F I L C F G I L L D S K L R Q L Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	7WU3	B2	Adhesion	Adhesion	ADGRF1	Homo sapiens	-	K6G	Gs/β1/γ2	3.1	2022-04-27	doi.org/10.1038/s41586-022-04580-w
	7WU3 (No Gprot)	B2	Adhesion	Adhesion	ADGRF1	Homo sapiens	-	K6G		3.1	2022-04-27	doi.org/10.1038/s41586-022-04580-w
	7WU4	B2	Adhesion	Adhesion	ADGRF1	Homo sapiens	-	K6G	Gi1/β1/γ2	3.4	2022-04-27	doi.org/10.1038/s41586-022-04580-w
	7WU4 (No Gprot)	B2	Adhesion	Adhesion	ADGRF1	Homo sapiens	-	K6G		3.4	2022-04-27	doi.org/10.1038/s41586-022-04580-w
	7WU5	B2	Adhesion	Adhesion	ADGRF1	Homo sapiens	-	K6G	Gi1/β1/γ2	3	2022-04-27	doi.org/10.1038/s41586-022-04580-w
	7WU5 (No Gprot)	B2	Adhesion	Adhesion	ADGRF1	Homo sapiens	-	K6G		3	2022-04-27	doi.org/10.1038/s41586-022-04580-w
	7WXU	B2	Adhesion	Adhesion	ADGRF1	Homo sapiens	-	-	chim(NtGi1-Gs-CtGq)/β1/γ2	2.85	2022-09-28	doi.org/10.1038/s41467-022-33173-4
	7WXU (No Gprot)	B2	Adhesion	Adhesion	ADGRF1	Homo sapiens	-	-		2.85	2022-09-28	doi.org/10.1038/s41467-022-33173-4
	7WXW	B2	Adhesion	Adhesion	ADGRF1	Homo sapiens	-	-	chim(NtGi1-Gs)/β1/γ2	2.84	2022-09-28	doi.org/10.1038/s41467-022-33173-4
	7WXW (No Gprot)	B2	Adhesion	Adhesion	ADGRF1	Homo sapiens	-	-		2.84	2022-09-28	doi.org/10.1038/s41467-022-33173-4
	7WY0	B2	Adhesion	Adhesion	ADGRF1	Homo sapiens	-	-	chim(NtGi1L-G13)/β1/γ2	2.83	2022-09-28	doi.org/10.1038/s41467-022-33173-4
	7WY0 (No Gprot)	B2	Adhesion	Adhesion	ADGRF1	Homo sapiens	-	-		2.83	2022-09-28	doi.org/10.1038/s41467-022-33173-4
	7WZ7	B2	Adhesion	Adhesion	ADGRF1	Homo sapiens	-	-	chim(NtGi1-G12)/β1/γ2	2.83	2022-09-28	doi.org/10.1038/s41467-022-33173-4
	7WZ7 (No Gprot)	B2	Adhesion	Adhesion	ADGRF1	Homo sapiens	-	-		2.83	2022-09-28	doi.org/10.1038/s41467-022-33173-4
	7X2V	B2	Adhesion	Adhesion	ADGRF1	Homo sapiens	-	-	Gi1/β1/γ2	3.09	2022-09-28	doi.org/10.1038/s41467-022-33173-4
	7X2V (No Gprot)	B2	Adhesion	Adhesion	ADGRF1	Homo sapiens	-	-		3.09	2022-09-28	doi.org/10.1038/s41467-022-33173-4
	8G2Y	B2	Adhesion	Adhesion	ADGRF1	Homo sapiens	-	LPC	chim(Gs-CtGq)/β1/γ2	3.44	2023-05-10	doi.org/10.1038/s41467-023-38083-7
	8G2Y (No Gprot)	B2	Adhesion	Adhesion	ADGRF1	Homo sapiens	-	LPC		3.44	2023-05-10	doi.org/10.1038/s41467-023-38083-7

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