Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg Int. Strength Num Of Links Community ConSurf
1A:A:Y37 8.7654184
2A:A:H41 6.7854106
3A:A:N50 6.3545199
4A:A:S51 3.4409
5A:A:F219 6.7508
6A:A:H220 10.585417
7A:A:F222 10.29517
8A:A:Q227 8.135419
9A:A:E230 9.095419
10A:A:K233 5.61833619
11A:A:W234 5.69719
12A:A:F238 7.71619
13A:A:V247 4.6354237
14A:A:D249 7.224198
15A:A:Y253 7.7945118
16A:A:F273 5.5456129
17A:A:W277 11.0154126
18A:A:W281 8.968525
19A:A:I288 4.6275409
20A:A:F290 5.124509
21A:A:N292 5.33254239
22A:A:K293 6.6225409
23A:A:Q294 7.07466
24A:A:L302 3.75754172
25A:A:Y311 5.6885116
26A:A:F312 5.783336118
27A:A:F315 11.58406
28A:A:V334 3.04254174
29A:A:K338 5.48465
30A:A:Y339 7.032563
31A:A:F340 8.3785117
32A:A:R342 6.50167664
33A:A:E344 8.0654115
34A:A:F345 9.02408
35A:A:R356 6.87754122
36A:A:Y358 6.465214
37A:A:Y360 8.55408
38A:A:P361 6.26465
39A:A:F363 7.24565
40A:A:R374 6.794204
41A:A:F376 5.728336108
42A:A:I383 4.46754108
43A:A:R385 7.19754215
44A:A:Y391 4.4975404
45A:A:L393 3.8625408
46A:A:L394 5.3856218
47B:B:L4 5.5725404
48B:B:R22 7.0425436
49B:B:V40 4.6725423
50B:B:H54 10.414599
51B:B:K57 11.415429
52B:B:W63 8.11407
53B:B:D76 6.15189
54B:B:K78 5.3525408
55B:B:I81 4.0445257
56B:B:W82 8.73857799
57B:B:K89 7.9499
58B:B:L95 4.3225268
59B:B:W99 10.4519
60B:B:M101 6.2775409
61B:B:N110 6.6354144
62B:B:Y111 6.31754144
63B:B:D118 4.44754279
64B:B:I120 5.1075406
65B:B:Y124 5.9745266
66B:B:H142 9.654519
67B:B:Y145 6.13429718
68B:B:F151 5.232509
69B:B:L152 4.858503
70B:B:T159 5.272519
71B:B:D163 8.59519
72B:B:W169 8.684518
73B:B:T173 4.38754285
74B:B:F180 8.23547
75B:B:H183 9.664549
76B:B:D186 6.832519
77B:B:V187 4.748549
78B:B:F199 7.8449
79B:B:S201 3.99449
80B:B:C204 5.254517
81B:B:D205 6.824549
82B:B:S207 4.1725445
83B:B:K209 8.88546
84B:B:L210 5.6475435
85B:B:W211 8.45548
86B:B:R214 5.7725409
87B:B:Q220 8.055437
88B:B:F222 8.8775438
89B:B:H225 8.84286739
90B:B:D228 7.562519
91B:B:I232 3.9575408
92B:B:F235 6.826526
93B:B:P236 6.3775427
94B:B:F241 6.27736
95B:B:T243 5.3538
96B:B:D246 7.1825419
97B:B:D247 9.6775439
98B:B:R251 12.506538
99B:B:F253 5.84286736
100B:B:D254 4.194509
101B:B:R256 8.15409
102B:B:D258 8.02537
103B:B:M262 5.35404
104B:B:Y264 6.802525
105B:B:F278 5.61833627
106B:B:R283 8.10167629
107B:B:Y289 7.15857727
108B:B:D290 5.375426
109B:B:C294 4.625475
110B:B:N295 7.7475426
111B:B:V296 3.58405
112B:B:W297 6.0875428
113B:B:D298 8.47429
114B:B:K301 6.052525
115B:B:H311 9.67579
116B:B:R314 10.2725428
117B:B:L318 4.9625406
118B:B:T329 5.19578
119B:B:W332 10.805629
120B:B:D333 9.7975479
121B:B:F335 7.055404
122B:B:L336 5.1375497
123B:B:K337 8.0675476
124B:B:W339 7.335479
125B:B:N340 6.52254139
126G:G:L19 3.338509
127G:G:R27 5.1725438
128G:G:Y40 13.6426
129G:G:D48 6.69509
130G:G:N59 6.064139
131G:G:F61 5.408577138
132R:R:S568 4.355459
133R:R:F569 6.2425229
134R:R:L572 6.4354229
135R:R:V577 5.0225453
136R:R:F582 14.64451
137R:R:K586 13.9375453
138R:R:F610 4.125308
139R:R:W611 4.1075409
140R:R:R624 4.294509
141R:R:V647 3.31405
142R:R:H665 6.33254319
143R:R:Y668 4.9925228
144R:R:L669 4.15319
145R:R:F672 7.6365329
146R:R:W674 10.7285159
147R:R:M675 3.40754329
148R:R:L682 4.1525409
149R:R:Y684 7.138588
150R:R:F690 6.0856108
151R:R:M693 4.0075485
152R:R:Y707 6.4165159
153R:R:P710 4.745409
154R:R:T721 4.4154169
155R:R:Y727 5.6656169
156R:R:K728 4.5575405
157R:R:W734 6.9575408
158R:R:L735 4.6625409
159R:R:W737 6.614296
160R:R:V762 3.725408
161R:R:T785 5.914337
162R:R:W804 11.16754329
163R:R:D813 4.25254344
164R:R:N816 5.90254345
165R:R:W819 5.8125346
166R:R:H820 7.004558
167R:R:N827 8.4775409
168R:R:F829 4.355407
169W:W:?1 6.3281080
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
1A:A:F273 A:A:F345 86.0127.5YesYes098
2A:A:F345 A:A:L270 10012.18YesNo086
3A:A:L270 A:A:Q267 63.88963.99NoNo064
4A:A:F312 A:A:Q267 63.89833.51YesNo084
5A:A:F312 A:A:I308 42.62643.77YesNo087
6A:A:I308 A:A:Y253 42.713810.88NoYes078
7A:A:K300 A:A:Y253 92.50659.55NoYes1198
8A:A:K300 A:A:S251 1003.06NoNo099
9A:A:D249 A:A:S251 1005.89YesNo089
10A:A:D249 A:A:K293 1008.3YesYes089
11A:A:K293 A:A:N292 10011.19YesYes099
12A:A:I56 A:A:N292 1004.25NoYes2379
13A:A:F290 A:A:I56 1005.02YesNo097
14A:A:F290 A:A:I288 65.54923.77YesYes099
15A:A:D378 A:A:I288 65.22625.6NoYes079
16A:A:D378 A:A:Y360 10012.64NoYes078
17A:A:Y358 A:A:Y360 1003.97YesYes048
18A:A:L394 A:A:Y358 1004.69YesYes2184
19A:A:L394 R:R:L769 1004.15YesNo087
20A:A:L388 R:R:L769 62.24124.15NoNo087
21A:A:L388 A:A:L393 62.01824.15NoYes088
22A:A:L393 R:R:L682 1004.15YesYes089
23A:A:Y391 R:R:L682 1003.52YesYes049
24A:A:Y391 R:R:T619 14.39853.75YesNo048
25A:A:E344 A:A:L270 64.01536.63YesNo056
26A:A:E344 A:A:F312 63.897911.66YesYes1158
27A:A:F312 A:A:Y311 85.32283.09YesYes1186
28A:A:Y253 A:A:Y311 42.62049.93YesYes1186
29A:A:S306 A:A:Y311 42.6193.82NoYes1176
30A:A:K300 A:A:S306 42.59083.06NoNo1197
31A:A:F290 A:A:H362 65.54917.92YesNo099
32A:A:D378 A:A:H362 65.229712.61NoNo079
33R:R:L769 R:R:S792 62.24123NoNo078
34A:A:L393 R:R:S792 62.01823YesNo088
35A:A:H387 R:R:T619 11.69514.11NoNo088
36A:A:H387 A:A:I383 10.36863.98NoYes088
37A:A:R231 A:A:W234 12.38884NoYes099
38A:A:L46 A:A:R231 12.58374.86NoNo089
39A:A:F246 A:A:L46 90.71613.65NoNo098
40B:B:C317 B:B:M61 10.23934.86NoNo076
41B:B:C317 B:B:S316 10.79985.16NoNo079
42B:B:S316 B:B:W332 11.08046.18NoYes099
43A:A:W281 B:B:R314 11.44319YesYes258
44A:A:F246 A:A:L289 49.01423.65NoNo099
45A:A:R280 A:A:W281 35.817716.99NoYes055
46A:A:R280 A:A:R283 35.8566.4NoNo053
47A:A:R283 A:A:R356 35.894414.93NoYes032
48A:A:H357 A:A:R356 35.96854.51NoYes1272
49A:A:N279 A:A:W281 77.71063.39NoYes085
50A:A:L282 A:A:N279 77.79969.61NoNo098
51A:A:Y391 R:R:R623 18.03257.2YesNo049
52A:A:Y391 R:R:L681 83.66043.52YesNo047
53B:B:C271 B:B:D290 1003.11NoYes256
54B:B:C271 B:B:Y289 1004.03NoYes257
55B:B:I273 B:B:Y289 91.46517.25NoYes067
56B:B:G244 B:B:I273 91.54025.29NoNo056
57B:B:G244 B:B:H225 90.9953.18NoYes059
58B:B:H225 B:B:T243 29.44885.48YesYes398
59B:B:F241 B:B:T243 28.89565.19YesYes368
60B:B:F241 B:B:L255 56.6793.65YesNo066
61B:B:L210 B:B:L255 56.39965.54YesNo056
62B:B:L210 B:B:R219 83.77654.86YesNo355
63B:B:D212 B:B:R219 83.35795.96NoNo095
64B:B:D212 B:B:E215 82.518216.89NoNo093
65B:B:E215 B:B:R214 82.09843.49NoYes039
66B:B:Q156 B:B:R214 405.84NoYes059
67B:B:L152 B:B:Q156 39.1593.99YesNo035
68B:B:L152 B:B:V158 73.26794.47YesNo035
69B:B:F199 B:B:V158 72.42633.93YesNo095
70B:B:F199 B:B:W211 60.63688.02YesYes498
71B:B:K209 B:B:W211 30.32014.64YesYes468
72B:B:K209 B:B:T221 21.057113.51YesNo467
73B:B:T221 G:G:E22 20.21599.88NoNo079
74G:G:E22 G:G:L19 38.74543.98NoYes099
75B:B:A11 G:G:L19 20.21581.58NoYes059
76B:B:A11 G:G:V16 18.53121.7NoNo057
77B:B:L7 G:G:V16 13.47744.47NoNo087
78B:B:F253 B:B:H225 59.59873.39YesYes369
79B:B:F241 B:B:F253 28.900110.72YesYes366
80B:B:F222 B:B:F253 30.303710.72YesYes386
81B:B:F222 B:B:Q220 28.48067.03YesYes387
82B:B:L210 B:B:Q220 28.21786.65YesYes357
83B:B:R214 B:B:V213 39.5795.23YesNo094
84B:B:L152 B:B:V213 39.15855.96YesNo034
85B:B:C218 B:B:W211 22.74037.84NoYes458
86B:B:C218 G:G:Q18 21.89849.16NoNo059
87G:G:E22 G:G:Q18 20.214110.19NoNo099
88B:B:L14 G:G:L19 13.47745.54NoYes089
89B:B:L70 B:B:W63 11.085911.39NoYes057
90R:R:L681 W:W:?1 80.96263.79NoYes870
91R:R:M677 W:W:?1 72.012911.63NoYes060
92R:R:M677 R:R:W674 70.66554.65NoYes069
93R:R:W674 R:R:Y707 68.866915.43YesYes1599
94R:R:S670 R:R:Y707 67.96945.09NoYes1589
95R:R:P710 R:R:S670 67.5213.56YesNo098
96R:R:L669 R:R:P710 66.17323.28YesYes099
97R:R:F747 R:R:L669 42.76734.87NoYes3189
98R:R:F747 R:R:W734 42.32746.01NoYes088
99R:R:I571 R:R:W734 13.52985.87NoYes078
100R:R:I571 R:R:S568 13.0794.64NoYes079
101R:R:L572 R:R:W734 28.400112.53YesYes098
102R:R:F569 R:R:L572 21.63854.87YesYes2299
103R:R:F569 R:R:N827 20.29064.83YesYes099
104R:R:H665 R:R:L669 21.60876.43YesYes3199
105R:R:R623 R:R:R624 11.72334.26NoYes099
106R:R:H665 R:R:L735 13.51665.14YesYes099
107A:A:I276 A:A:L282 77.88932.85NoNo089
108A:A:W234 B:B:Y145 11.17823.86YesYes198
109A:A:H357 A:A:W277 36.054523.27NoYes1276
110A:A:I276 A:A:L46 78.06972.85NoNo088
111A:A:F246 A:A:F273 41.79115.36NoYes099
112A:A:F345 A:A:L289 41.79188.53YesNo089
113A:A:F273 A:A:W277 36.06546.01YesYes1296
114A:A:W281 B:B:D290 1006.7YesYes256
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


2D representation of the interactions of this orthosteric/allosteric ligand.


Links and nodes colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
A:A:Y391 R:R:L681 3.52 0 Yes No 4 7 2 1
R:R:L681 R:R:T622 4.42 8 No No 7 7 1 1
R:R:M698 R:R:T622 6.02 8 No No 8 7 1 1
R:R:T622 W:W:?1 4.04 8 No Yes 7 0 1 0
R:R:C626 W:W:?1 4.35 0 No Yes 7 0 1 0
R:R:M677 R:R:W674 4.65 0 No Yes 6 9 1 2
R:R:L705 R:R:M677 4.24 0 No No 6 6 2 1
R:R:M677 W:W:?1 11.63 0 No Yes 6 0 1 0
R:R:L681 W:W:?1 3.79 8 No Yes 7 0 1 0
R:R:R685 R:R:Y684 11.32 0 No Yes 8 8 2 1
R:R:L688 R:R:Y684 3.52 8 No Yes 6 8 1 1
R:R:H691 R:R:Y684 7.62 8 No Yes 7 8 1 1
R:R:M693 R:R:Y684 3.59 8 Yes Yes 5 8 2 1
R:R:Y684 W:W:?1 9.64 8 Yes Yes 8 0 1 0
R:R:I687 R:R:L688 4.28 0 No No 6 6 2 1
R:R:L688 W:W:?1 11.38 8 No Yes 6 0 1 0
R:R:H691 R:R:M693 5.25 8 No Yes 7 5 1 2
R:R:H691 W:W:?1 5.87 8 No Yes 7 0 1 0
R:R:M693 R:R:M698 5.78 8 Yes No 5 8 2 1
R:R:M698 W:W:?1 5.17 8 No Yes 8 0 1 0
R:R:G702 W:W:?1 4.69 0 No Yes 7 0 1 0
R:R:V701 W:W:?1 2.72 0 No Yes 6 0 1 0

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

ShowSimilarityNetwork TypeNameLigandDescription
58.33Single8G2YLPC8G2Y-ADGRF1-LPC-chim(Gs-CtGq)/&β;1/&γ;2
53.33Single7WU4K6G7WU4-ADGRF1-K6G-Gi1/&β;1/&γ;2
46.67Single7WU5K6G7WU5-ADGRF1-K6G-Gi1/&β;1/&γ;2
33.33Single5KW2PubChem 1330539535KW2-FFA1 (GPR40)-PubChem 133053953
31.25Consensusadgrf1_on_alloOther Ligand7WU5-ADGRF1-K6G-Gi1/&β;1/&γ;2 8G2Y-ADGRF1-LPC-chim(Gs-CtGq)/&β;1/&γ;2
25.00Single5XSZGlyceryl Mono-oleate5XSZ-LPA6-Glyceryl Mono-oleate
20.00Single7LJDMevidalen7LJD-D1-Dopamine-Mevidalen-Gs/&β;1/&γ;1
20.00Single7X2FMevidalen7X2F-D1-Dopamine-Mevidalen-Gs/&β;1/&γ;2
19.05Single5TZYMK8666; PubChem 1270535975TZY-FFA1 (GPR40)-MK8666; PubChem 127053597
18.75Single7LJCMevidalen7LJC-D1-PubChem 86764103-Mevidalen-Gs/&β;1/&γ;2
17.65Single6N48PubChem 1384542566N48-β2-BI167107-PubChem 138454256
12.50Single7CKZMevidalen7CKZ-D1-Dopamine-Mevidalen-Gs/&β;1/&γ;2
12.00Single7SHFPI; PE7SHF-GPR158-PI; PE-B5; RGS7
11.76Consensusd1_on_alloOther Ligand7LJC-D1-PubChem 86764103-Mevidalen-Gs/&β;1/&γ;2 7CKZ-D1-Dopamine-Mevidalen-Gs/&β;1/&γ;2
11.11Single5O9HNDT95137275O9H-C5a1-NDT9513727
9.09Single7SHEPI; PE7SHE-GPR158-PI; PE
7.69Single4PXFOctyl Beta-D-Glucopyranoside4PXF-Rhodopsin-Octyl Beta-D-Glucopyranoside-Arrestin1_Finger_loop
7.69Single7SHEPI; PE7SHE-GPR158-PI; PE
7.14Single8U4NCholesterol8U4N-CXCR4-Cholesterol-Gi1/&β;1/&γ;2
6.67Single8U4PCholesterol8U4P-CXCR4-AMD3100-Cholesterol-Gi1/&β;1/&γ;2
6.25Single8U4OCholesterol8U4O-CXCR4-CXCL12-Cholesterol-Gi1/&β;1/&γ;2
6.25Single8U4RCholesterol8U4R-CXCR4-REGN7663-Fab-Cholesterol
6.25Single8WG8Peptide8WG8-Glucagon-Peptide-chim(NtGi1-Gs)/&β;1/&γ;2
5.88Single8U4QCholesterol8U4Q-CXCR4-REGN7663-Fab-Cholesterol-Gi1/&β;1/&γ;2
5.56Single6C1QNDT95137276C1Q-C5a1-PMX53-NDT9513727
5.56Single8G94CD698G94-S1P1-CD69-Gi1/&β;1/&γ;2
5.26Single8IYXYL-3658IYX-GPR34-YL-365
5.00Single6C1RAvacopan; Na6C1R-C5a1-PMX53-Avacopan; Na
5.00Consensusc5a1_off_ortoalloOther Ligand6C1Q-C5a1-PMX53-NDT9513727 6C1R-C5a1-PMX53-Avacopan; Na
4.17Single7SHFPI; PE7SHF-GPR158-PI; PE-B5; RGS7

PDB Summary
PDB 7WU3
Class B2
SubFamily Adhesion
Type Adhesion
SubType ADGRF1
Species Homo sapiens
Ligand -
Other Ligand(s) K6G
Protein Partners Gs/Beta1/Gamma2
PDB Resolution 3.1
Date 2022-04-27
D.O.I. 10.1038/s41586-022-04580-w
Net Summary
Imin 3.06
Number of Linked Nodes 846
Number of Links 1031
Number of Hubs 169
Number of Links mediated by Hubs 630
Number of Communities 34
Number of Nodes involved in Communities 243
Number of Links involved in Communities 340
Path Summary
Number Of Nodes in MetaPath 115
Number Of Links MetaPath 114
Number of Shortest Paths 23326774
Length Of Smallest Path 3
Average Path Length 75.3636
Length of Longest Path 81
Minimum Path Strength 1.49
Average Path Strength 8.00465
Maximum Path Strength 22.875
Minimum Path Correlation 0.7
Average Path Correlation 1
Maximum Path Correlation 1
Minimum % Of Corr. Nodes 1.92308
Average % Of Corr. Nodes 31.9631
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 64.1547
Maximum Path Hubs % 100
AnnotationTypeLinks
Gene OntologyMolecular Function
Gene OntologyBiological Process
Gene OntologyCellular Component
SCOP2Domain Identifier
SCOP2Family Identifier
Membrane Protein Annotations-• Orientations of Proteins in Membranes database (OPM)   • Protein Data Bank of Transmembrane Proteins (PDBTM)   • MemProtMD


Details about the values in these tables can be found in the corresponding documentation page .
CodeK6G
PDB ResiduesW:W:?1
Environment DetailsOpen EMBL-EBI Page
CodeK6G
Name[(2~{R})-2-oxidanyl-3-[oxidanyl-[2-(trimethyl-$l^{4}-azanyl)ethoxy]phosphoryl]oxy-propyl] hexadecanoate
Synonyms
Identifier[(2~{R})-2-oxidanyl-3-[oxidanyl-[2-(trimethyl-$l^{4}-azanyl)ethoxy]phosphoryl]oxy-propyl] hexadecanoate
FormulaC24 H51 N O7 P
Molecular Weight496.638
SMILESCCCCCCCCCCCCCCCC(=O)OC[C@H](COP(=O)(O)OCC[N](C)(C)C)O
PubChem
Formal Charge0
Total Atoms84
Total Chiral Atoms1
Total Bonds83
Total Aromatic Bonds0

PDBsumOpen PDBsum Page
ChainA
ProteinG Protein α Sub unit
UniProtP63092
Sequence
>7WU3_Chain_A
IEKQLQKDK QVYRATHRL LLLGADNSG KSTIVKIFE TKFQVDKVN 
FHMFDVGGQ RDERRKWIQ CFNDVTAII FVVDSSDYN RLQEALNDF 
KSIWNNRWL RTISVILFL NKQDLLAEK VLAGKSKIE DYFPEFARY 
TTPEDATPE PGEDPRVTR AKYFIRDEF LRISTASGD GRHYCYPHF 
TCAVDTENA RRIFNDCRD IIQRMHLRQ YELL


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainB
ProteinG Protein β Sub unit
UniProtP62873
Sequence
>7WU3_Chain_B
SELDQLRQE AEQLKNQIR DARKACADA TLSQITNNI DPVGRIQMR 
TRRTLRGHL AKIYAMHWG TDSRLLVSA SQDGKLIIW DSYTTNKVH 
AIPLRSSWV MTCAYAPSG NYVACGGLD NICSIYNLK TREGNVRVS 
RELAGHTGY LSCCRFLDD NQIVTSSGD TTCALWDIE TGQQTTTFT 
GHTGDVMSL SLAPDTRLF VSGACDASA KLWDVREGM CRQTFTGHE 
SDINAICFF PNGNAFATG SDDATCRLF DLRADQELM TYSHDNIIC 
GITSVSFSK SGRLLLAGY DDFNCNVWD ALKADRAGV LAGHDNRVS 
CLGVTDDGM AVATGSWDS FLKIWN


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainG
ProteinG Protein γ Sub unit
UniProtP59768
Sequence
>7WU3_Chain_G
ASIAQARKL VEQLKMEAN IDRIKVSKA AADLMAYCE AHAKEDPLL 
TPVPASENP FR


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainR
ProteinReceptor
UniProtQ5T601
Sequence
>7WU3_Chain_R
TSFSILMSP FVPSTIFPV VKWITYVGL GISIGSLIL CLIIEALFW 
KQIKKSQTS HTRRICMVN IALSLLIAD VWFIVGATV SGVCTAAVF 
FTHFFYLSL FFWMLMLGI LLAYRIILV FHHMAQHLM MAVGFCLGY 
GCPLIISVI TIAVTQPSN TYKRKDVCW LNWSNGSKP LLAFVVPAL 
AIVAVNFVV VLLVLTKLW RPTVGERLS RDDKATIIR VGKSLLILT 
PLLGLTWGF GIGTIVDSQ NLAWHVIFA LLNAFQGFF ILCFGILLD 
SKLRQLLFN K


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  




This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
7WU3B2AdhesionAdhesionADGRF1Homo sapiens-K6GGs/&β;1/&γ;23.12022-04-2710.1038/s41586-022-04580-w
7WU4B2AdhesionAdhesionADGRF1Homo sapiens-K6GGi1/&β;1/&γ;23.42022-04-2710.1038/s41586-022-04580-w
7WU5B2AdhesionAdhesionADGRF1Homo sapiens-K6GGi1/&β;1/&γ;232022-04-2710.1038/s41586-022-04580-w
7WXUB2AdhesionAdhesionADGRF1Homo sapiens--chim(NtGi1-Gs-CtGq)/&β;1/&γ;22.852022-09-2810.1038/s41467-022-33173-4
7WXWB2AdhesionAdhesionADGRF1Homo sapiens--chim(NtGi1-Gs)/&β;1/&γ;22.842022-09-2810.1038/s41467-022-33173-4
7WY0B2AdhesionAdhesionADGRF1Homo sapiens--chim(NtGi1L-G13)/&β;1/&γ;22.832022-09-2810.1038/s41467-022-33173-4
7WZ7B2AdhesionAdhesionADGRF1Homo sapiens--chim(NtGi1-G12)/&β;1/&γ;22.832022-09-2810.1038/s41467-022-33173-4
7X2VB2AdhesionAdhesionADGRF1Homo sapiens--Gi1/&β;1/&γ;23.092022-09-2810.1038/s41467-022-33173-4
8G2YB2AdhesionAdhesionADGRF1Homo sapiens-LPCchim(Gs-CtGq)/&β;1/&γ;23.442023-05-1010.1038/s41467-023-38083-7




You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download 7WU3.zip



You can click to copy the link of this page to easily come back here later

or use this QR code to link and share this page.



You can also  read or  download a guide explaining the meaning of all files and numerical data.