Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg Int. Strength Num Of Links Community ConSurf
1A:A:I60 6.045447
2A:A:L61 4.84538
3A:A:L62 6.8875449
4A:A:D66 4.305408
5A:A:K70 5.2625449
6A:A:F73 7.03833647
7A:A:M77 7.032549
8A:A:H81 10.906548
9A:A:F216 5.192549
10A:A:I218 9.7525445
11A:A:F223 5.47407
12A:A:K224 8.32754187
13A:A:K237 5.045429
14A:A:C241 3.71428
15A:A:F242 6.1675439
16A:A:I245 6.0375439
17A:A:I248 4.40667638
18A:A:L249 4.658548
19A:A:F250 7.4475439
20A:A:M251 5.6325447
21A:A:V252 5.4437
22A:A:F277 7.006539
23A:A:I280 4.69667638
24A:A:V281 7.1575437
25A:A:F286 5.84667639
26A:A:I292 4.478549
27A:A:L293 9.315439
28A:A:F294 5.50429749
29A:A:Y330 4.585127
30A:A:F335 9.4575438
31A:A:R337 9.5354124
32A:A:L346 6.9675436
33A:A:F347 5.125449
34A:A:H348 9.7375435
35A:A:I362 4.8375449
36B:B:T34 4.1925105
37B:B:V40 5.2385103
38B:B:I43 4.5275403
39B:B:L51 6.825409
40B:B:H54 9.671676119
41B:B:W63 8.355407
42B:B:V71 5.188578
43B:B:Q75 8.3825429
44B:B:D76 8.36254119
45B:B:I81 5.36477
46B:B:W82 10.2085119
47B:B:S84 4.2854135
48B:B:Y85 13.27254134
49B:B:N88 5.91407
50B:B:K89 8.976676119
51B:B:H91 6.295475
52B:B:I93 7.4075477
53B:B:L95 5.025478
54B:B:W99 11.364509
55B:B:Y105 4.685676
56B:B:N110 5.00254164
57B:B:Y111 5.9854164
58B:B:V112 4.5875478
59B:B:C114 4.06578
60B:B:L117 6.7975429
61B:B:Y124 5.55676
62B:B:T128 4.2975403
63B:B:V133 6.1474
64B:B:H142 6.572529
65B:B:Y145 5.5875828
66B:B:L146 3.86427
67B:B:F151 4.835609
68B:B:I157 4.382527
69B:B:V158 3.545455
70B:B:T159 6.4575429
71B:B:S161 7.1075429
72B:B:D163 8.49429
73B:B:L168 3.9175456
74B:B:W169 8.71143728
75B:B:F180 7.688557
76B:B:H183 9.81333659
77B:B:V187 5.854559
78B:B:L190 5.2425455
79B:B:F199 7.59667659
80B:B:V200 5.885466
81B:B:C204 5.5075427
82B:B:D205 5.526559
83B:B:K209 10.85456
84B:B:L210 5.722505
85B:B:W211 9.01286758
86B:B:R219 4.20254225
87B:B:Q220 6.7725467
88B:B:F222 6.9475468
89B:B:H225 10.1383669
90B:B:D228 6.8475429
91B:B:I232 5.4775468
92B:B:F234 5.4125405
93B:B:F235 7.321437146
94B:B:F241 7.798566
95B:B:T243 7.38468
96B:B:D247 5.876569
97B:B:R251 10.576568
98B:B:F253 7.34666
99B:B:D254 6.995409
100B:B:R256 12.0875409
101B:B:D258 11.2775467
102B:B:Q259 4.6175406
103B:B:M262 5.7525404
104B:B:Y264 7.918505
105B:B:H266 10.08494
106B:B:I269 4.656594
107B:B:F278 6.15407
108B:B:R283 7.1125109
109B:B:L285 5.21406
110B:B:L286 5.515487
111B:B:Y289 6.43857797
112B:B:N293 4.3125495
113B:B:N295 6.03496
114B:B:V296 4.2405
115B:B:L300 4.9254106
116B:B:K301 5.1625105
117B:B:R304 6.7175495
118B:B:H311 7.955689
119B:B:L318 3.65486
120B:B:M325 6.995405
121B:B:W332 12.372529
122B:B:D333 7.3625489
123B:B:K337 8.1625486
124B:B:W339 8.852589
125G:G:L19 3.1085209
126G:G:Y40 7.09754146
127G:G:D48 7.69409
128G:G:L51 4.3954106
129G:G:N59 6.7825139
130G:G:P60 8.57754139
131G:G:F61 5.046258138
132R:R:S568 4.855419
133R:R:F569 5.65719
134R:R:S570 7.8425419
135R:R:L572 5.876519
136R:R:M573 4.92519
137R:R:S574 4.2475419
138R:R:V577 5.64333613
139R:R:P578 6.0125414
140R:R:I581 4.236514
141R:R:S596 3.90754159
142R:R:L600 7.254159
143R:R:E607 5.514249
144R:R:F610 6.38508
145R:R:R624 8.8754249
146R:R:M627 3.682507
147R:R:L634 6.934159
148R:R:I636 4.255407
149R:R:D638 6.23754157
150R:R:W640 7.4175406
151R:R:V647 2.5725405
152R:R:F662 5.145418
153R:R:H665 4.0325419
154R:R:F666 6.182517
155R:R:Y668 5.914518
156R:R:L669 5.4675419
157R:R:F672 6.436509
158R:R:F673 7.69418
159R:R:W674 13.765179
160R:R:L676 5.3775407
161R:R:M677 3.785406
162R:R:F690 7.542548
163R:R:Y707 8.21754179
164R:R:P710 5.7125419
165R:R:T721 5.0675419
166R:R:T726 3.7325414
167R:R:Y727 6.69667619
168R:R:W734 6.61667618
169R:R:L735 7.135409
170R:R:P743 5.1825418
171R:R:L744 4.9675418
172R:R:F747 4.18418
173R:R:L800 8.4275409
174R:R:W804 8.94125819
175R:R:T810 4.2925417
176R:R:W819 13.045406
177R:R:H820 9.17667618
178R:R:F823 7.8425419
179R:R:F829 4.34237
180R:R:F832 4.86754235
181R:R:L835 4.45408
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
1B:B:D66 B:B:R68 82.33323.57NoNo085
2B:B:D66 B:B:L69 82.52275.43NoNo085
3B:B:L69 B:B:Y105 82.71195.86NoYes056
4B:B:V71 B:B:Y105 78.47175.05YesYes786
5B:B:L79 B:B:V71 80.29444.47NoYes078
6B:B:C114 B:B:L79 81.67633.17YesNo087
7B:B:C114 B:B:G115 88.06223.92YesNo089
8B:B:D118 B:B:G115 99.53965.03NoNo099
9B:B:D118 B:B:G116 99.8463.35NoNo099
10B:B:G116 B:B:M101 1003.49NoNo099
11A:A:C241 B:B:M101 66.69173.24YesNo089
12A:A:C241 B:B:Q75 32.95113.05YesYes289
13B:B:Q75 B:B:W99 34.1414.24YesYes099
14A:A:E213 B:B:W99 89.206710.9NoYes099
15A:A:E213 A:A:K224 89.076110.8NoYes097
16A:A:K224 A:A:L57 88.44898.46YesNo1876
17A:A:L57 A:A:P222 88.41834.93NoNo064
18A:A:P222 A:A:R56 70.11712.88NoNo044
19A:A:R56 R:R:H691 69.95866.77NoNo047
20R:R:H691 R:R:Y684 68.52249.8NoNo078
21R:R:R685 R:R:Y684 67.62043.09NoNo088
22R:R:R685 R:R:T619 67.29733.88NoNo088
23A:A:D377 R:R:T619 25.847510.12NoNo048
24A:A:D377 R:R:S620 25.02854.42NoNo048
25R:R:R624 R:R:S620 24.85715.27YesNo098
26A:A:C241 B:B:L117 32.9943.17YesYes289
27B:B:L117 B:B:W99 73.597610.25YesYes099
28B:B:M101 B:B:Y145 33.69693.59NoYes098
29B:B:L117 B:B:Y145 40.80863.52YesYes298
30A:A:I221 A:A:P222 27.5283.39NoNo044
31A:A:I221 R:R:F690 27.100413.82NoYes448
32A:A:V366 R:R:F690 25.23663.93NoYes498
33A:A:I60 A:A:V366 16.61093.07YesNo479
34A:A:F242 B:B:W99 35.248812.03YesYes099
35A:A:F242 A:A:L61 34.63356.09YesYes398
36A:A:I248 A:A:L61 32.7174.28YesYes388
37A:A:I248 A:A:I291 30.8754.42YesNo386
38A:A:F277 A:A:I291 28.27615.02YesNo396
39A:A:F277 A:A:L346 26.57454.87YesYes396
40A:A:D336 A:A:L346 13.25124.07NoYes346
41A:A:D336 A:A:V332 13.03632.92NoNo345
42A:A:F350 A:A:V332 25.67942.62NoNo055
43A:A:F350 A:A:Q328 25.242619.91NoNo055
44A:A:H348 A:A:L346 13.252312.86YesYes356
45A:A:H348 A:A:V332 13.07958.3YesNo355
46A:A:Q333 A:A:R337 13.35144.67NoYes1234
47A:A:D326 A:A:H322 18.66573.78NoNo051
48A:A:H322 A:A:R323 19.10569.03NoNo015
49A:A:E325 A:A:R323 19.54533.49NoNo045
50A:A:E325 A:A:L324 19.984810.6NoNo043
51A:A:L324 A:A:Q328 20.86325.32NoNo035
52A:A:D326 A:A:Y330 10.66869.2NoYes1257
53A:A:I378 R:R:T619 41.63113.04NoNo058
54A:A:I378 R:R:L682 41.31929.99NoNo059
55R:R:E607 R:R:R624 22.1599.3YesYes2499
56R:R:E607 R:R:I839 22.02834.1YesNo097
57R:R:I839 R:R:M627 18.29654.37NoYes077
58B:B:R68 B:B:Y85 78.627926.75NoYes054
59B:B:Y85 G:G:P60 66.150415.3YesYes1349
60B:B:M325 G:G:P60 64.86686.71YesYes059
61B:B:M325 G:G:P49 63.79778.39YesNo057
62G:G:D48 G:G:P49 63.17854.83YesNo097
63G:G:D48 G:G:L51 54.62646.79YesYes096
64B:B:R283 G:G:L51 46.45364.86YesYes1096
65B:B:L300 B:B:R283 42.79184.86YesYes1069
66B:B:L30 B:B:L300 40.16785.54NoYes1056
67B:B:L30 B:B:M262 40.20197.07NoYes054
68B:B:M262 B:B:Y264 39.06739.58YesYes045
69B:B:L252 B:B:Y264 28.91495.86NoYes075
70B:B:L252 B:B:L261 25.40734.15NoNo075
71B:B:L261 G:G:V30 23.03134.47NoNo058
72B:B:Q259 G:G:V30 22.79045.73YesNo068
73B:B:Q259 B:B:R22 22.06678.18YesNo066
74B:B:D258 B:B:R22 14.973615.48YesNo076
75B:B:C148 B:B:T102 18.19535.07NoNo068
76B:B:L146 B:B:T102 17.19022.95YesNo078
77B:B:G115 B:B:L146 13.42943.42NoYes097
78B:B:C148 B:B:L190 15.85513.17NoYes065
79R:R:L682 R:R:V765 41.13834.47NoNo099
80R:R:V761 R:R:V765 40.96261.6NoNo089
81R:R:V757 R:R:V761 40.6231.6NoNo078
82R:R:L676 R:R:V757 40.4552.98YesNo077
83R:R:I754 R:R:L676 39.28318.56NoYes097
84R:R:F672 R:R:I754 33.45955.02YesNo099
85R:R:F672 R:R:W804 30.361614.03YesYes099
86R:R:M573 R:R:W804 13.50393.49YesYes199
87R:R:G807 R:R:M573 11.7273.49NoYes099
88R:R:G807 R:R:T810 23.5533.64NoYes097
89R:R:F823 R:R:W804 11.91497.02YesYes199
90R:R:F823 R:R:G807 12.26773.01YesNo099
91R:R:H820 R:R:T810 14.9395.48YesYes187
92R:R:T567 R:R:V732 10.30593.17NoNo094
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


PDB Summary
PDB 7WZ7
Class B2
SubFamily Adhesion
Type Adhesion
SubType ADGRF1
Species Homo sapiens
Ligand -
Other Ligand(s) -
Protein Partners chim(NtGi1-G12)/Beta1/Gamma2
PDB Resolution 2.83
Date 2022-09-28
D.O.I. 10.1038/s41467-022-33173-4
Net Summary
Imin 2.92
Number of Linked Nodes 837
Number of Links 1033
Number of Hubs 181
Number of Links mediated by Hubs 630
Number of Communities 24
Number of Nodes involved in Communities 241
Number of Links involved in Communities 356
Path Summary
Number Of Nodes in MetaPath 93
Number Of Links MetaPath 92
Number of Shortest Paths 1376882
Length Of Smallest Path 3
Average Path Length 35.4045
Length of Longest Path 73
Minimum Path Strength 1.17
Average Path Strength 6.38938
Maximum Path Strength 21.025
Minimum Path Correlation 0.7
Average Path Correlation 0.983207
Maximum Path Correlation 1
Minimum % Of Corr. Nodes 3.125
Average % Of Corr. Nodes 41.4612
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 43.6984
Maximum Path Hubs % 100
AnnotationTypeLinks
Gene OntologyMolecular Function
Gene OntologyBiological Process
Gene OntologyCellular Component
SCOP2Domain Identifier
SCOP2Family Identifier
Membrane Protein Annotations-• Orientations of Proteins in Membranes database (OPM)   • Protein Data Bank of Transmembrane Proteins (PDBTM)   • MemProtMD


Details about the values in these tables can be found in the corresponding documentation page .
PDBsumOpen PDBsum Page
ChainA
ProteinG Protein α Sub unit
UniProtQ03113
Sequence
>7WZ7_Chain_A
LSAEDKAAV ERSKMIDAL LARERRAVR RLVKILLLG ADNSGKSTF 
LKQMRIIHV NKGIVEHDF VIKKIPFKM VDVRQKWFQ CFDGITSIL 
FMVDSSDNR LVESMNDFE TIVNNKLFF NVSIILFLN KMDLLVEKV 
KTVSIKKHF PDFRGDPHR LEDVQRYLV QCFDRKRRN RSKPLFHHF 
TTSIDTENA RFIFHAVKD TILQENLKD IML


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainB
ProteinG Protein β Sub unit
UniProtP62873
Sequence
>7WZ7_Chain_B
ELDQLRQEA EQLKNQIRD ARKACADAT LSQITNNID PVGRIQMRT 
RRTLRGHLA KIYAMHWGT DSRLLVSAS QDGKLIIWD SYTTNKVHA 
IPLRSSWVM TCAYAPSGN YVACGGLDN ICSIYNLKT REGNVRVSR 
ELAGHTGYL SCCRFLDDN QIVTSSGDT TCALWDIET GQQTTTFTG 
HTGDVMSLS LAPDTRLFV SGACDASAK LWDVREGMC RQTFTGHES 
DINAICFFP NGNAFATGS DDATCRLFD LRADQELMT YSHDNIICG 
ITSVSFSKS GRLLLAGYD DFNCNVWDA LKADRAGVL AGHDNRVSC 
LGVTDDGMA VATGSWDSF LKIWN


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainG
ProteinG Protein γ Sub unit
UniProtP59768
Sequence
>7WZ7_Chain_G
TASIAQARK LVEQLKMEA NIDRIKVSK AAADLMAYC EAHAKEDPL 
LTPVPASEN PFR


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainR
ProteinReceptor
UniProtQ5T601
Sequence
>7WZ7_Chain_R
TSFSILMSP FVPSTIFPV VKWITYVGL GISIGSLIL CLIIEALFW 
KQKSQTSHT RRICMVNIA LSLLIADVW FIVGATVDT TVNPSGVCT 
AAVFFTHFF YLSLFFWML MLGILLAYR IILVFHHMA QHLMMAVGF 
CLGYGCPLI ISVITIAVT QPSNTYKRK DVCWLNWSN GSKPLLAFV 
VPALAIVAV NFVVVLLVL TKLATIIRV GKSLLILTP LLGLTWGFG 
IGTIVDSQN LAWHVIFAL LNAFQGFFI LCFGILLDS KLRQLLFNK 
LS


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  




This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
7WU3B2AdhesionAdhesionADGRF1Homo sapiens-K6GGs/&β;1/&γ;23.12022-04-2710.1038/s41586-022-04580-w
7WU4B2AdhesionAdhesionADGRF1Homo sapiens-K6GGi1/&β;1/&γ;23.42022-04-2710.1038/s41586-022-04580-w
7WU5B2AdhesionAdhesionADGRF1Homo sapiens-K6GGi1/&β;1/&γ;232022-04-2710.1038/s41586-022-04580-w
7WXUB2AdhesionAdhesionADGRF1Homo sapiens--chim(NtGi1-Gs-CtGq)/&β;1/&γ;22.852022-09-2810.1038/s41467-022-33173-4
7WXWB2AdhesionAdhesionADGRF1Homo sapiens--chim(NtGi1-Gs)/&β;1/&γ;22.842022-09-2810.1038/s41467-022-33173-4
7WY0B2AdhesionAdhesionADGRF1Homo sapiens--chim(NtGi1L-G13)/&β;1/&γ;22.832022-09-2810.1038/s41467-022-33173-4
7WZ7B2AdhesionAdhesionADGRF1Homo sapiens--chim(NtGi1-G12)/&β;1/&γ;22.832022-09-2810.1038/s41467-022-33173-4
7X2VB2AdhesionAdhesionADGRF1Homo sapiens--Gi1/&β;1/&γ;23.092022-09-2810.1038/s41467-022-33173-4
8G2YB2AdhesionAdhesionADGRF1Homo sapiens-LPCchim(Gs-CtGq)/&β;1/&γ;23.442023-05-1010.1038/s41467-023-38083-7




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