Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg Int. Strength Num Of Links Community ConSurf
1A:A:L52 7.9225419
2A:A:L53 5.272509
3A:A:F64 10.705497
4A:A:Q67 5.37499
5A:A:Y209 5.84754177
6A:A:F211 5.93754168
7A:A:I213 8.80254165
8A:A:P217 3.4525404
9A:A:F218 8.768336167
10A:A:R232 4.964589
11A:A:W233 10.385619
12A:A:F234 7.65833619
13A:A:E235 6.6525488
14A:A:F237 7.79719
15A:A:S242 4.395408
16A:A:L246 7.205497
17A:A:F272 8.2845189
18A:A:V276 4.9375406
19A:A:F281 5.48619
20A:A:F289 6.07125899
21A:A:E311 4.97405
22A:A:F325 5.62406
23A:A:Y343 11.2525409
24A:A:F346 9.5445155
25A:A:N351 8.015499
26A:A:N354 8.268599
27A:A:L371 4.54118
28A:A:L376 5.1565118
29B:B:D27 6.475408
30B:B:M45 4.485474
31B:B:R48 5.8675427
32B:B:R49 7.4427
33B:B:H54 10.9409
34B:B:Y59 7.8275408
35B:B:M61 4.8975426
36B:B:W63 7.628527
37B:B:D76 7.365409
38B:B:K78 7.36408
39B:B:I80 8.6225428
40B:B:W82 10.1033629
41B:B:Y85 14.3625424
42B:B:N88 6.2825407
43B:B:K89 8.28667629
44B:B:H91 6.6775405
45B:B:I93 6.1475457
46B:B:L95 5.555458
47B:B:W99 6.89875819
48B:B:Y105 4.79756
49B:B:Y111 6.13504
50B:B:V112 4.1875458
51B:B:C114 4.21833658
52B:B:L117 5.32519
53B:B:I123 5.79416
54B:B:Y124 5.54857756
55B:B:L126 4.85455
56B:B:T128 3.735203
57B:B:V133 6.1454
58B:B:H142 6.95714719
59B:B:Y145 9.12833618
60B:B:R150 5.905406
61B:B:F151 5.93167619
62B:B:T159 8.17419
63B:B:D163 7.128519
64B:B:C166 3.81468
65B:B:W169 9.975618
66B:B:Q176 7.5575414
67B:B:F180 7.198567
68B:B:H183 7.625669
69B:B:V187 5.072569
70B:B:F199 7.424569
71B:B:S201 4.7975469
72B:B:K209 10.5525466
73B:B:L210 7.07405
74B:B:W211 8.55333668
75B:B:C218 5.69465
76B:B:Q220 7.485437
77B:B:F222 5.68333638
78B:B:H225 9.01429739
79B:B:D228 7.9225489
80B:B:I232 5.095438
81B:B:F234 6.8225405
82B:B:F235 7.494297126
83B:B:P236 6.354127
84B:B:F241 6.79167636
85B:B:D246 7.29489
86B:B:D247 7.434539
87B:B:R251 11.864538
88B:B:F253 6.5675436
89B:B:D258 8.6437
90B:B:M262 6.8825404
91B:B:Y264 6.714505
92B:B:F278 6.8285127
93B:B:R283 7.641676149
94B:B:L285 5.4125406
95B:B:Y289 6.456676217
96B:B:C294 4.665475
97B:B:N295 7.93254216
98B:B:V296 4.9525405
99B:B:H311 8.576579
100B:B:R314 12.788588
101B:B:V315 3.9675477
102B:B:M325 5.87525
103B:B:T329 5.785408
104B:B:W332 15.466589
105B:B:D333 7.52479
106B:B:K337 7.085476
107B:B:W339 8.03167679
108B:B:N340 5.3725429
109G:G:L19 3.485409
110G:G:R27 5.7625408
111G:G:Y40 8.364126
112G:G:D48 8.305409
113G:G:L51 6.0375406
114G:G:N59 8.135629
115G:G:P60 9.0525429
116G:G:F61 6.41667928
117G:G:R62 10.4375407
118R:R:F569 5.74833649
119R:R:L572 5.3325409
120R:R:M573 4.85649
121R:R:P578 4.754504
122R:R:I581 4.22404
123R:R:F610 5.144228
124R:R:R624 5.293336109
125R:R:D638 5.902507
126R:R:F662 6.34448
127R:R:H665 4.5375449
128R:R:Y668 6.388508
129R:R:L669 4.46549
130R:R:F672 9.64509
131R:R:F673 4.9375408
132R:R:W674 9.267139
133R:R:M675 5.5975409
134R:R:Y684 10.135408
135R:R:R685 9.32508
136R:R:F690 7.2575408
137R:R:F703 6.0854138
138R:R:Y707 6.636139
139R:R:Y727 8.09571749
140R:R:W734 6.205608
141R:R:F747 5.68648
142R:R:L796 4.63254119
143R:R:W804 12.394549
144R:R:T810 4.395447
145R:R:H820 8.1525448
146R:R:F823 7.438549
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
1B:B:H54 B:B:I80 21.49110.61YesYes098
2B:B:H54 B:B:S74 49.808716.74YesNo099
3B:B:D76 B:B:S74 49.7927.36YesNo099
4B:B:D76 B:B:K78 52.620511.06YesYes098
5B:B:D76 B:B:L55 1009.5YesNo096
6A:A:K42 B:B:L55 99.47064.23NoNo056
7A:A:K42 A:A:K46 99.20555.75NoNo054
8B:B:L70 B:B:W82 26.64964.56NoYes259
9B:B:L70 B:B:M61 24.05918.48NoYes256
10B:B:C317 B:B:M61 30.26823.24NoYes076
11B:B:C317 B:B:S316 30.15493.44NoNo079
12B:B:S316 B:B:W332 30.10724.94NoYes099
13A:A:E235 A:A:V280 16.9657.13YesNo085
14A:A:F281 A:A:V280 16.75375.24YesNo095
15A:A:K50 A:A:L48 21.5765.64NoNo096
16A:A:L48 A:A:P217 21.30263.28NoYes064
17A:A:K46 R:R:H692 98.674513.1NoNo046
18A:A:F281 A:A:L52 11.88113.65YesYes199
19A:A:F237 A:A:L52 12.240515.83YesYes199
20A:A:F234 A:A:F281 15.2767.5YesYes199
21A:A:F234 A:A:F237 12.39947.5YesYes199
22B:B:L95 B:B:Y124 12.26345.86YesYes586
23B:B:L95 B:B:V100 23.09434.47YesNo589
24B:B:V100 B:B:Y59 46.721913.88NoYes098
25B:B:Q75 B:B:Y59 46.00546.76NoYes098
26A:A:C236 B:B:Q75 45.87584.58NoNo099
27A:A:C236 B:B:W99 19.87843.92NoYes199
28B:B:C114 B:B:Y124 12.78215.38YesYes586
29B:B:C114 B:B:V100 23.77433.42YesNo589
30A:A:P217 A:A:V216 20.36513.53YesNo044
31A:A:F218 A:A:V216 18.69316.55YesNo074
32B:B:R314 B:B:W332 20.241822.99YesYes889
33B:B:D290 B:B:R314 31.547921.44NoYes068
34A:A:F281 A:A:I275 28.40855.02YesNo098
35A:A:I275 A:A:V276 27.40763.07NoYes086
36A:A:F272 A:A:V276 23.38639.18YesYes096
37A:A:F245 A:A:F272 13.288213.93NoYes099
38A:A:F245 A:A:V247 12.78039.18NoNo097
39A:A:S268 A:A:V247 12.27214.85NoNo087
40A:A:L265 A:A:S268 11.76373NoNo098
41A:A:F252 A:A:L265 11.2553.65NoNo099
42A:A:F252 A:A:K299 10.74619.93NoNo099
43R:R:H692 R:R:R685 98.40874.51NoYes068
44R:R:R685 R:R:T619 26.637616.82YesNo088
45A:A:L374 R:R:T619 24.99854.42NoNo058
46A:A:L374 R:R:L682 24.66995.54NoNo059
47A:A:L376 R:R:L682 23.3534.15YesNo089
48A:A:L376 R:R:L796 19.70345.54YesYes1189
49R:R:L796 R:R:V762 18.37872.98YesNo098
50R:R:L802 R:R:V762 14.98875.96NoNo078
51R:R:L802 R:R:T797 13.98024.42NoNo079
52R:R:P798 R:R:T797 13.013.5NoNo099
53R:R:F833 R:R:P798 11.99622.89NoNo079
54R:R:F832 R:R:F833 11.65775.36NoNo057
55R:R:F832 R:R:S599 10.98015.28NoNo058
56R:R:L835 R:R:S599 10.64087.51NoNo088
57B:B:C271 B:B:D290 35.45763.11NoNo056
58B:B:C271 B:B:D291 35.09614.67NoNo058
59B:B:D291 B:B:Y289 34.16564.6NoYes087
60B:B:W297 B:B:Y289 31.84499.65NoYes2187
61B:B:W297 B:B:Y264 31.837210.61NoYes085
62B:B:M262 B:B:Y264 20.87258.38YesYes045
63B:B:L30 B:B:M262 19.05711.31NoYes054
64B:B:L261 B:B:L30 18.8548.3NoNo055
65B:B:L261 G:G:V30 18.03954.47NoNo058
66B:B:Q259 G:G:V30 17.01565.73NoNo068
67B:B:Q259 B:B:R22 16.60432.34NoNo066
68B:B:D258 B:B:R22 10.73999.53YesNo076
69B:B:M325 G:G:P49 11.19466.71YesNo057
70B:B:R283 G:G:L51 11.24647.29YesYes096
71B:B:N340 G:G:F61 11.55513.62YesYes298
72B:B:L51 B:B:W82 15.902414.81NoYes299
73B:B:I338 B:B:L51 23.57817.14NoNo259
74B:B:S72 B:B:W82 20.63878.65NoYes299
75B:B:H62 B:B:Y105 11.10885.44NoYes066
76B:B:H62 B:B:R150 10.92919.03NoYes066
77B:B:K78 B:B:P94 52.58943.35YesNo085
78B:B:I93 B:B:P94 52.65993.39YesNo075
79B:B:I93 B:B:Y124 26.50144.84YesYes576
80B:B:I93 B:B:L79 22.03077.14YesNo577
81B:B:L79 B:B:L95 10.91965.54NoYes578
82B:B:C114 B:B:L79 11.2344.76YesNo587
83B:B:H142 B:B:S161 11.309412.55YesNo199
84B:B:G162 B:B:S161 12.70383.71NoNo199
85R:R:L681 R:R:R685 73.67533.64NoYes078
86R:R:L681 R:R:T622 73.38695.9NoNo077
87R:R:Q695 R:R:T622 73.01284.25NoNo067
88R:R:H621 R:R:Q695 72.72287.42NoNo066
89R:R:H621 R:R:I625 72.1429.28NoNo067
90R:R:I625 R:R:M699 71.85135.83NoNo077
91R:R:F703 R:R:M699 71.56023.73YesNo087
92R:R:F703 R:R:W674 37.71038.02YesYes1389
93R:R:I630 R:R:W674 34.41153.52NoYes089
94R:R:I630 R:R:M675 34.10314.37NoYes089
95R:R:F672 R:R:M675 29.00567.46YesYes099
96R:R:F672 R:R:F747 13.33485.36YesYes098
97R:R:F747 R:R:W734 15.03797.02YesYes088
98R:R:F703 R:R:Y707 33.23894.13YesYes1389
99R:R:S670 R:R:Y707 23.10727.63NoYes1389
100R:R:P710 R:R:S670 22.82413.56NoNo098
101R:R:L669 R:R:P710 22.22433.28YesNo099
102R:R:F747 R:R:L669 13.41034.87YesYes489
103R:R:F672 R:R:W804 14.563623.05YesYes099
104R:R:F823 R:R:W804 10.9746.01YesYes499
105R:R:F823 R:R:T810 11.11663.89YesYes497
106A:A:C236 A:A:F237 25.9028.38NoYes199
107B:B:I338 G:G:F61 20.393411.3NoYes258
108A:A:K50 B:B:W99 17.9774.64NoYes099
109B:B:H54 B:B:S72 28.42716.97YesNo099
110B:B:I80 B:B:W82 20.739216.44YesYes289
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


PDB Summary
PDB 7WY0
Class B2
SubFamily Adhesion
Type Adhesion
SubType ADGRF1
Species Homo sapiens
Ligand -
Other Ligand(s) -
Protein Partners chim(NtGi1L-G13)/Beta1/Gamma2
PDB Resolution 2.83
Date 2022-09-28
D.O.I. 10.1038/s41467-022-33173-4
Net Summary
Imin 3.2
Number of Linked Nodes 838
Number of Links 1005
Number of Hubs 146
Number of Links mediated by Hubs 545
Number of Communities 22
Number of Nodes involved in Communities 199
Number of Links involved in Communities 294
Path Summary
Number Of Nodes in MetaPath 111
Number Of Links MetaPath 110
Number of Shortest Paths 1169222
Length Of Smallest Path 3
Average Path Length 30.9837
Length of Longest Path 62
Minimum Path Strength 1.29
Average Path Strength 6.82062
Maximum Path Strength 30.06
Minimum Path Correlation 0.71
Average Path Correlation 0.979769
Maximum Path Correlation 1
Minimum % Of Corr. Nodes 2.63158
Average % Of Corr. Nodes 43.5688
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 40.8733
Maximum Path Hubs % 100
AnnotationTypeLinks
Gene OntologyMolecular Function
Gene OntologyBiological Process
Gene OntologyCellular Component
SCOP2Domain Identifier
SCOP2Family Identifier
Membrane Protein Annotations-• Orientations of Proteins in Membranes database (OPM)   • Protein Data Bank of Transmembrane Proteins (PDBTM)   • MemProtMD


Details about the values in these tables can be found in the corresponding documentation page .
PDBsumOpen PDBsum Page
ChainA
ProteinG Protein α Sub unit
UniProtQ14344
Sequence
>7WY0_Chain_A
LSAEDKAAV ERSKMIDKC LSREKTYVK RLVKILLLG AGESGKSTF 
LKQMRIIHV NKGIHEYDF EIKNVPFKM VDVSERKRW FECFDSVTS 
ILFLVSSSE FLTESLNIF ETIVNNRVF SNVSIILFL NKTDLLEEK 
VQIVSIKDY FLEFEGDPH CLRDVQKFL VECFRNKRR KPLYHHFTT 
SINTENIRL VFRDVKDTI LHDNLKQLM LQ


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainB
ProteinG Protein β Sub unit
UniProtP62873
Sequence
>7WY0_Chain_B
ELDQLRQEA EQLKNQIRD ARKACADAT LSQITNNID PVGRIQMRT 
RRTLRGHLA KIYAMHWGT DSRLLVSAS QDGKLIIWD SYTTNKVHA 
IPLRSSWVM TCAYAPSGN YVACGGLDN ICSIYNLKT REGNVRVSR 
ELAGHTGYL SCCRFLDDN QIVTSSGDT TCALWDIET GQQTTTFTG 
HTGDVMSLS LAPDTRLFV SGACDASAK LWDVREGMC RQTFTGHES 
DINAICFFP NGNAFATGS DDATCRLFD LRADQELMT YSHDNIICG 
ITSVSFSKS GRLLLAGYD DFNCNVWDA LKADRAGVL AGHDNRVSC 
LGVTDDGMA VATGSWDSF LKIWN


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainG
ProteinG Protein γ Sub unit
UniProtP59768
Sequence
>7WY0_Chain_G
TASIAQARK LVEQLKMEA NIDRIKVSK AAADLMAYC EAHAKEDPL 
LTPVPASEN PFR


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainR
ProteinReceptor
UniProtQ5T601
Sequence
>7WY0_Chain_R
TSFSILMSP FVPSTIFPV VKWITYVGL GISIGSLIL CLIIEALFW 
KQIKKSQTS HTRRICMVN IALSLLIAD VWFIVGATV DTTVNPSGV 
CTAAVFFTH FFYLSLFFW MLMLGILLA YRIILVFHH MAQHLMMAV 
GFCLGYGCP LIISVITIA VTQPSNTYK RKDVCWLNW SNGSKPLLA 
FVVPALAIV AVNFVVVLL VLTKLWRPA TIIRVGKSL LILTPLLGL 
TWGFGIGTI VDSQNLAWH VIFALLNAF QGFFILCFG ILLDSKLRQ 
LLFNKLS


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  




This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
7WU3B2AdhesionAdhesionADGRF1Homo sapiens-K6GGs/&β;1/&γ;23.12022-04-2710.1038/s41586-022-04580-w
7WU4B2AdhesionAdhesionADGRF1Homo sapiens-K6GGi1/&β;1/&γ;23.42022-04-2710.1038/s41586-022-04580-w
7WU5B2AdhesionAdhesionADGRF1Homo sapiens-K6GGi1/&β;1/&γ;232022-04-2710.1038/s41586-022-04580-w
7WXUB2AdhesionAdhesionADGRF1Homo sapiens--chim(NtGi1-Gs-CtGq)/&β;1/&γ;22.852022-09-2810.1038/s41467-022-33173-4
7WXWB2AdhesionAdhesionADGRF1Homo sapiens--chim(NtGi1-Gs)/&β;1/&γ;22.842022-09-2810.1038/s41467-022-33173-4
7WY0B2AdhesionAdhesionADGRF1Homo sapiens--chim(NtGi1L-G13)/&β;1/&γ;22.832022-09-2810.1038/s41467-022-33173-4
7WZ7B2AdhesionAdhesionADGRF1Homo sapiens--chim(NtGi1-G12)/&β;1/&γ;22.832022-09-2810.1038/s41467-022-33173-4
7X2VB2AdhesionAdhesionADGRF1Homo sapiens--Gi1/&β;1/&γ;23.092022-09-2810.1038/s41467-022-33173-4
8G2YB2AdhesionAdhesionADGRF1Homo sapiens-LPCchim(Gs-CtGq)/&β;1/&γ;23.442023-05-1010.1038/s41467-023-38083-7




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Download 7WY0.zip



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