psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:S568	R:R:T567	3.2	Yes	No	0	9	9
2	R:R:F582	R:R:T567	9.08	No	No	0	1	9
3	R:R:T567	R:R:V732	3.17	No	No	0	9	4
4	R:R:S568	R:R:S570	6.52	Yes	Yes	1	9	9
5	R:R:S568	R:R:V577	4.85	Yes	Yes	1	9	3
6	R:R:S568	R:R:V585	4.85	Yes	No	0	9	8
7	R:R:F569	R:R:L572	7.31	Yes	Yes	1	9	9
8	R:R:F569	R:R:T589	6.49	Yes	No	0	9	9
9	R:R:F569	R:R:L593	8.53	Yes	No	0	9	8
10	R:R:F569	R:R:Y668	7.22	Yes	Yes	1	9	8
11	R:R:F569	R:R:W804	4.01	Yes	Yes	1	9	9
12	R:R:F569	R:R:F823	3.22	Yes	No	1	9	9
13	R:R:S570	R:R:S574	3.26	Yes	Yes	1	9	9
14	R:R:S570	R:R:V577	4.85	Yes	Yes	1	9	3
15	R:R:H820	R:R:S570	16.74	Yes	Yes	1	8	9
16	R:R:I571	R:R:R729	3.76	No	No	0	7	5
17	R:R:I571	R:R:V732	4.61	No	No	0	7	4
18	R:R:F641	R:R:L572	3.65	No	Yes	0	9	9
19	R:R:L572	R:R:Y668	7.03	Yes	Yes	1	9	8
20	R:R:L572	R:R:W734	4.56	Yes	Yes	1	9	8
21	R:R:L572	R:R:W804	6.83	Yes	Yes	1	9	9
22	R:R:M573	R:R:V748	6.09	Yes	No	1	9	7
23	R:R:L752	R:R:M573	4.24	No	Yes	0	8	9
24	R:R:M573	R:R:W804	3.49	Yes	Yes	1	9	9
25	R:R:G807	R:R:M573	3.49	No	Yes	0	9	9
26	R:R:I811	R:R:M573	7.29	No	Yes	1	5	9
27	R:R:P575	R:R:S574	3.56	No	Yes	1	6	9
28	R:R:S574	R:R:T810	3.2	Yes	Yes	1	9	7
29	R:R:H820	R:R:S574	6.97	Yes	Yes	1	8	9
30	R:R:P575	R:R:W737	12.16	No	No	1	6	6
31	R:R:L744	R:R:P575	3.28	Yes	No	1	8	6
32	R:R:F576	R:R:S814	3.96	No	No	0	3	5
33	R:R:P578	R:R:V577	3.53	Yes	Yes	1	4	3
34	R:R:F582	R:R:V577	7.87	No	Yes	0	1	3
35	R:R:H820	R:R:V577	9.69	Yes	Yes	1	8	3
36	R:R:I581	R:R:P578	3.39	Yes	Yes	1	4	4
37	R:R:L817	R:R:P578	4.93	No	Yes	0	2	4
38	R:R:H820	R:R:P578	12.2	Yes	Yes	1	8	4
39	R:R:I581	R:R:V585	9.22	Yes	No	0	4	8
40	R:R:H820	R:R:I581	3.98	Yes	Yes	1	8	4
41	R:R:K586	R:R:Y590	9.55	No	No	0	3	5
42	R:R:I588	R:R:W587	3.52	No	No	0	9	4
43	R:R:V591	R:R:W587	6.13	No	No	0	7	4
44	R:R:I642	R:R:Y590	3.63	No	No	0	8	5
45	R:R:A645	R:R:Y590	4	No	No	0	7	5
46	R:R:F829	R:R:G592	9.03	Yes	No	0	7	9
47	R:R:D638	R:R:L593	5.43	Yes	No	0	7	8
48	R:R:L600	R:R:S596	4.5	Yes	No	4	9	9
49	R:R:D638	R:R:S596	4.42	Yes	No	0	7	9
50	R:R:G831	R:R:S596	3.71	No	No	4	9	9
51	R:R:D638	R:R:I597	5.6	Yes	No	0	7	7
52	R:R:I597	R:R:V639	4.61	No	No	0	7	6
53	R:R:G598	R:R:I601	3.53	No	No	0	3	5
54	R:R:L835	R:R:S599	7.51	Yes	No	0	8	8
55	R:R:L600	R:R:L634	11.07	Yes	No	0	9	9
56	R:R:L600	R:R:L635	8.3	Yes	No	0	9	8
57	R:R:G831	R:R:L600	5.13	No	Yes	4	9	9
58	R:R:L602	R:R:L835	4.15	No	Yes	0	6	8
59	R:R:C603	R:R:L835	4.76	No	Yes	0	7	8
60	R:R:C603	R:R:I839	3.27	No	No	0	7	7
61	R:R:F610	R:R:I606	5.02	Yes	No	0	8	8
62	R:R:E607	R:R:W611	4.36	Yes	No	5	9	9
63	R:R:E607	R:R:R624	9.3	Yes	Yes	5	9	9
64	R:R:E607	R:R:V628	4.28	Yes	No	0	9	7
65	R:R:E607	R:R:I839	4.1	Yes	No	0	9	7
66	R:R:F610	R:R:L609	9.74	Yes	No	0	8	4
67	R:R:F610	R:R:L848	4.87	Yes	No	0	8	7
68	R:R:F610	R:R:L849	7.31	Yes	No	0	8	7
69	R:R:F610	R:R:K852	4.96	Yes	No	0	8	4
70	R:R:H621	R:R:W611	4.23	No	No	0	6	9
71	R:R:R624	R:R:W611	10	Yes	No	5	9	9
72	R:R:L848	R:R:Q613	3.99	No	No	0	7	5
73	R:R:K852	R:R:Q613	4.07	No	No	0	4	5
74	R:R:Q618	R:R:Q695	6.4	Yes	No	0	7	6
75	R:R:R685	R:R:T619	3.88	No	No	0	8	8
76	R:R:R624	R:R:S620	5.27	Yes	No	0	9	8
77	R:R:H621	R:R:I625	3.98	No	No	0	6	7
78	R:R:H621	R:R:Q695	8.65	No	No	0	6	6
79	R:R:L681	R:R:T622	8.84	No	No	0	7	7
80	R:R:M698	R:R:T622	4.52	No	No	0	8	7
81	R:R:M627	R:R:R623	3.72	Yes	No	0	7	9
82	R:R:L845	R:R:R624	10.93	No	Yes	0	8	9
83	R:R:C626	R:R:W674	3.92	No	Yes	0	7	9
84	R:R:C626	R:R:L678	4.76	No	Yes	0	7	8
85	R:R:L799	R:R:M627	5.65	No	Yes	0	6	7
86	R:R:I839	R:R:M627	4.37	No	Yes	0	7	7
87	R:R:N629	R:R:W674	33.9	No	Yes	2	9	9
88	R:R:F703	R:R:N629	4.83	No	No	2	8	9
89	R:R:N629	R:R:Y707	4.65	No	Yes	2	9	9
90	R:R:I630	R:R:W674	3.52	No	Yes	0	8	9
91	R:R:I630	R:R:M675	7.29	No	No	0	8	9
92	R:R:S633	R:R:S670	6.52	No	No	0	8	8
93	R:R:D638	R:R:L634	9.5	Yes	No	0	7	9
94	R:R:L634	R:R:L671	4.15	No	No	0	9	7
95	R:R:I636	R:R:L635	4.28	Yes	No	0	7	8
96	R:R:F667	R:R:I636	7.54	No	Yes	0	8	7
97	R:R:A637	R:R:Y668	5.34	No	Yes	0	9	8
98	R:R:V643	R:R:W640	3.68	No	Yes	0	8	6
99	R:R:F663	R:R:W640	21.05	No	Yes	0	8	6
100	R:R:G644	R:R:V647	3.68	No	Yes	0	6	5
101	R:R:C733	R:R:V647	3.42	No	Yes	0	9	5
102	R:R:D648	R:R:T650	7.23	No	No	0	5	3
103	R:R:C657	R:R:T649	3.38	No	No	0	9	3
104	R:R:N652	R:R:V651	4.43	No	No	0	4	1
105	R:R:N652	R:R:V656	5.91	No	No	0	4	5
106	R:R:C657	R:R:C733	7.28	No	No	0	9	9
107	R:R:T658	R:R:Y727	3.75	No	Yes	0	6	9
108	R:R:K728	R:R:T658	4.5	No	No	0	5	6
109	R:R:V661	R:R:Y727	12.62	No	Yes	0	8	9
110	R:R:V661	R:R:W734	3.68	No	Yes	0	8	8
111	R:R:F662	R:R:F666	3.22	No	Yes	1	8	7
112	R:R:F662	R:R:S714	9.25	No	No	1	8	9
113	R:R:F662	R:R:I718	5.02	No	No	0	8	7
114	R:R:T664	R:R:W734	7.28	No	Yes	0	7	8
115	R:R:H665	R:R:S714	5.58	No	No	1	9	9
116	R:R:H665	R:R:W734	4.23	No	Yes	1	9	8
117	R:R:F747	R:R:H665	3.39	Yes	No	1	8	9
118	R:R:F666	R:R:F667	6.43	Yes	No	0	7	8
119	R:R:F666	R:R:P710	8.67	Yes	Yes	1	7	9
120	R:R:F666	R:R:L711	7.31	Yes	No	0	7	7
121	R:R:F666	R:R:S714	5.28	Yes	No	1	7	9
122	R:R:F747	R:R:Y668	5.16	Yes	Yes	1	8	8
123	R:R:W804	R:R:Y668	4.82	Yes	Yes	1	9	8
124	R:R:F673	R:R:L669	6.09	Yes	Yes	1	8	9
125	R:R:L669	R:R:P710	4.93	Yes	Yes	1	9	9
126	R:R:I713	R:R:L669	4.28	No	Yes	0	9	9
127	R:R:L669	R:R:P750	6.57	Yes	No	0	9	9
128	R:R:S670	R:R:Y707	7.63	No	Yes	0	8	9
129	R:R:F672	R:R:L671	3.65	Yes	No	0	9	7
130	R:R:L671	R:R:M675	4.24	No	No	0	7	9
131	R:R:A751	R:R:F672	5.55	No	Yes	0	9	9
132	R:R:F672	R:R:I754	5.02	Yes	No	0	9	9
133	R:R:F672	R:R:V755	3.93	Yes	No	0	9	8
134	R:R:F672	R:R:W804	14.03	Yes	Yes	0	9	9
135	R:R:C709	R:R:F673	11.17	No	Yes	0	8	8
136	R:R:F673	R:R:P710	7.22	Yes	Yes	1	8	9
137	R:R:F673	R:R:I754	6.28	Yes	No	0	8	9
138	R:R:F703	R:R:W674	12.03	No	Yes	2	8	9
139	R:R:W674	R:R:Y707	15.43	Yes	Yes	2	9	9
140	R:R:I680	R:R:L676	7.14	No	Yes	0	8	7
141	R:R:I754	R:R:L676	8.56	No	Yes	0	9	7
142	R:R:G702	R:R:M677	3.49	No	Yes	0	7	6
143	R:R:L705	R:R:M677	7.07	No	Yes	0	6	6
144	R:R:L678	R:R:L799	6.92	Yes	No	0	8	6
145	R:R:L678	R:R:L800	4.15	Yes	Yes	0	8	9
146	R:R:G679	R:R:L800	3.42	No	Yes	0	9	9
147	R:R:L682	R:R:V765	4.47	No	No	0	9	9
148	R:R:H691	R:R:Y684	9.8	No	No	0	7	8
149	R:R:M693	R:R:Y684	7.18	No	No	0	5	8
150	R:R:I686	R:R:L764	7.14	No	No	0	7	7
151	R:R:I686	R:R:K768	7.27	No	No	0	7	8
152	R:R:H691	R:R:L688	7.71	No	No	0	7	6
153	R:R:M693	R:R:M698	4.33	No	No	0	5	8
154	R:R:A694	R:R:H696	5.85	No	No	0	8	5
155	R:R:H696	R:R:L697	12.86	No	No	0	5	3
156	R:R:F703	R:R:Y707	5.16	No	Yes	2	8	9
157	R:R:A746	R:R:T717	5.03	No	No	0	9	9
158	R:R:I718	R:R:Q722	6.86	No	No	0	7	7
159	R:R:I718	R:R:Y727	8.46	No	Yes	0	7	9
160	R:R:T721	R:R:Y727	8.74	No	Yes	0	9	9
161	R:R:P743	R:R:T721	5.25	Yes	No	0	8	9
162	R:R:S741	R:R:T726	3.2	No	No	6	8	4
163	R:R:P743	R:R:T726	6.99	Yes	No	6	8	4
164	R:R:L735	R:R:Y727	3.52	Yes	Yes	0	9	9
165	R:R:N736	R:R:R729	15.67	No	No	0	8	5
166	R:R:D731	R:R:K730	13.83	No	No	0	3	2
167	R:R:L735	R:R:W734	15.94	Yes	Yes	0	9	8
168	R:R:F747	R:R:W734	4.01	Yes	Yes	1	8	8
169	R:R:L735	R:R:P743	4.93	Yes	Yes	0	9	8
170	R:R:L735	R:R:L744	4.15	Yes	Yes	0	9	8
171	R:R:K742	R:R:W737	17.4	No	No	0	7	6
172	R:R:L744	R:R:W737	7.97	Yes	No	1	8	6
173	R:R:P743	R:R:S741	3.56	Yes	No	6	8	8
174	R:R:K742	R:R:L745	5.64	No	No	0	7	8
175	R:R:L744	R:R:V748	4.47	Yes	No	1	8	7
176	R:R:L745	R:R:V749	5.96	No	No	0	8	7
177	R:R:A751	R:R:F747	4.16	No	Yes	0	9	8
178	R:R:I811	R:R:V748	6.14	No	No	1	5	7
179	R:R:P750	R:R:V749	3.53	No	No	0	9	7
180	R:R:I808	R:R:L752	12.85	No	No	0	7	8
181	R:R:L800	R:R:N758	19.22	Yes	No	0	9	9
182	R:R:F759	R:R:L763	7.31	No	No	0	4	4
183	R:R:L766	R:R:V762	4.47	No	No	0	7	8
184	R:R:L796	R:R:V762	5.96	No	No	0	9	8
185	R:R:L769	R:R:R788	4.86	No	No	0	7	7
186	R:R:G790	R:R:V789	3.68	No	No	0	5	8
187	R:R:F837	R:R:L794	10.96	No	No	0	8	6
188	R:R:I795	R:R:L841	8.56	No	No	0	7	5
189	R:R:L796	R:R:L800	6.92	No	Yes	0	9	9
190	R:R:P798	R:R:T797	3.5	No	No	0	9	9
191	R:R:L802	R:R:T797	11.79	No	No	0	7	9
192	R:R:F833	R:R:P798	7.22	No	No	0	7	9
193	R:R:N827	R:R:T803	7.31	No	No	0	9	9
194	R:R:F823	R:R:W804	7.02	No	Yes	1	9	9
195	R:R:N827	R:R:W804	21.47	No	Yes	1	9	9
196	R:R:Q830	R:R:W804	9.86	No	Yes	0	9	9
197	R:R:F806	R:R:I822	8.79	No	No	0	8	5
198	R:R:F806	R:R:L826	4.87	No	No	0	8	6
199	R:R:G807	R:R:T810	3.64	No	Yes	0	9	7
200	R:R:G809	R:R:W819	11.26	No	Yes	0	7	6
201	R:R:T810	R:R:W819	4.85	Yes	Yes	0	7	6
202	R:R:H820	R:R:T810	5.48	Yes	Yes	1	8	7
203	R:R:D813	R:R:Q815	9.14	No	No	0	4	3
204	R:R:D813	R:R:W819	7.82	No	Yes	0	4	6
205	R:R:N816	R:R:W819	28.25	No	Yes	0	5	6
206	R:R:F823	R:R:N827	18.12	No	No	1	9	9
207	R:R:F829	R:R:F832	3.22	Yes	Yes	3	7	5
208	R:R:G831	R:R:I834	3.53	No	No	0	9	9
209	R:R:F832	R:R:F833	5.36	Yes	No	0	5	7
210	R:R:C836	R:R:F832	8.38	No	Yes	0	7	5
211	R:R:F833	R:R:F837	7.5	No	No	0	7	8
212	R:R:F837	R:R:L841	4.87	No	No	0	8	5
213	R:R:D842	R:R:L845	12.21	No	No	0	9	8
214	R:R:K844	R:R:L848	12.69	No	No	0	8	7
215	R:R:P723	R:R:Q722	3.16	No	No	0	8	7
216	R:R:T717	R:R:T721	3.14	No	No	0	9	9
217	R:R:R685	R:R:Y684	3.09	No	No	0	8	8
218	R:R:I588	R:R:V584	3.07	No	No	0	9	3
219	R:R:L766	R:R:S792	3	No	No	0	7	8
220	R:R:L769	R:R:S792	3	No	No	0	7	8
221	R:R:L676	R:R:V757	2.98	Yes	No	0	7	7
222	R:R:L705	R:R:V701	2.98	No	No	0	6	6
223	R:R:L711	R:R:V715	2.98	No	No	0	7	6
224	R:R:L802	R:R:V762	2.98	No	No	0	7	8
225	R:R:L793	R:R:T797	2.95	No	No	0	7	9
226	R:R:I601	R:R:I605	2.94	No	No	0	5	6
227	R:R:D648	R:R:T649	2.89	No	No	0	5	3
228	R:R:Q815	R:R:S814	2.89	No	No	0	3	5
229	R:R:I601	R:R:L635	2.85	No	No	0	5	8
230	R:R:I605	R:R:L609	2.85	No	No	0	6	4
231	R:R:I636	R:R:L632	2.85	Yes	No	0	7	5
232	R:R:I687	R:R:L688	2.85	No	No	0	6	6
233	R:R:I687	R:R:L764	2.85	No	No	0	6	7
234	R:R:L676	R:R:M677	2.83	Yes	Yes	0	7	6
235	R:R:K728	R:R:N725	2.8	No	No	0	5	4
236	R:R:K742	R:R:N739	2.8	No	No	0	7	4
237	R:R:A828	R:R:F569	2.77	No	Yes	0	8	9
238	R:R:A659	R:R:F663	2.77	No	No	0	7	8
239	R:R:L678	R:R:L682	2.77	Yes	No	0	8	9
240	R:R:A784	R:R:R788	2.77	No	No	0	6	7
241	R:R:L849	R:R:L853	2.77	No	No	0	7	4
242	R:R:M698	R:R:Q618	2.72	No	Yes	0	8	7
243	R:R:K612	R:R:Q613	2.71	No	No	0	7	5
244	R:R:F690	R:R:V689	2.62	No	No	0	8	9
245	R:R:A660	R:R:W640	2.59	No	Yes	0	7	6
246	R:R:R788	R:R:T785	2.59	No	No	0	7	7
247	R:R:F829	R:R:I595	2.51	Yes	No	3	7	7
248	R:R:F832	R:R:I595	2.51	Yes	No	3	5	7
249	R:R:F759	R:R:L802	2.44	No	No	0	4	7
250	R:R:F829	R:R:L825	2.44	Yes	No	0	7	5
251	R:R:F850	R:R:N851	2.42	No	No	0	3	4
252	R:R:I636	R:R:W640	2.35	Yes	Yes	0	7	6
253	R:R:G708	R:R:P710	2.03	No	Yes	0	6	9
254	R:R:A660	R:R:G644	1.95	No	No	0	7	6
255	R:R:G655	R:R:S654	1.86	No	No	0	3	4
256	R:R:G592	R:R:V591	1.84	No	No	0	9	7
257	R:R:G805	R:R:V755	1.84	No	No	0	6	8
258	R:R:G809	R:R:V812	1.84	No	No	0	7	6
259	R:R:G655	R:R:T658	1.82	No	No	0	3	6
260	R:R:A631	R:R:C603	1.81	No	No	0	8	7
261	R:R:G838	R:R:M627	1.75	No	Yes	0	8	7
262	R:R:G801	R:R:M675	1.75	No	No	0	9	9
263	R:R:G706	R:R:M677	1.75	No	Yes	0	9	6
264	R:R:G594	R:R:L593	1.71	No	No	0	5	8
265	R:R:A824	R:R:V585	1.7	No	No	0	8	8
266	R:R:A683	R:R:V761	1.7	No	No	0	6	8
267	R:R:N652	R:R:P653	1.63	No	No	0	4	4
268	R:R:S579	R:R:T580	1.6	No	No	0	3	3
269	R:R:V647	R:R:V656	1.6	Yes	No	0	5	5
270	R:R:S724	R:R:T726	1.6	No	No	0	3	4
271	R:R:V757	R:R:V761	1.6	No	No	0	7	8
272	R:R:V761	R:R:V765	1.6	No	No	0	8	9
273	R:R:T646	R:R:V647	1.59	No	Yes	0	5	5
274	R:R:A818	R:R:N816	1.56	No	No	0	6	5
275	R:R:I642	R:R:V643	1.54	No	No	0	8	8
276	R:R:I716	R:R:V720	1.54	No	No	0	7	5
277	R:R:K616	R:R:S617	1.53	No	No	0	7	8
278	R:R:I581	R:R:T580	1.52	Yes	No	0	4	3
279	R:R:K768	R:R:T767	1.5	No	No	0	8	4
280	R:R:L604	R:R:V628	1.49	No	No	0	8	7
281	R:R:L766	R:R:V789	1.49	No	No	0	7	8
282	R:R:I712	R:R:I716	1.47	No	No	0	5	7
283	R:R:L826	R:R:T803	1.47	No	No	0	6	9
284	R:R:D731	R:R:V732	1.46	No	No	0	3	4
285	R:R:F582	R:R:P583	1.44	No	No	0	1	1
286	R:R:Q618	R:R:S617	1.44	Yes	No	0	7	8
287	R:R:L835	R:R:L840	1.38	Yes	No	0	8	7
288	R:R:L840	R:R:L849	1.38	No	No	0	7	7
289	R:R:M699	R:R:Q695	1.36	No	No	0	7	6
290	R:R:N851	R:R:Q847	1.32	No	No	0	4	6
291	R:R:H692	R:R:Q618	1.24	No	Yes	0	6	7

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	R:R:S568	4.855	4	1	9
2	R:R:F569	5.65	7	1	9
3	R:R:S570	7.8425	4	1	9
4	R:R:L572	5.876	5	1	9
5	R:R:M573	4.92	5	1	9
6	R:R:S574	4.2475	4	1	9
7	R:R:V577	6.158	5	1	3
8	R:R:P578	6.0125	4	1	4
9	R:R:I581	4.5275	4	1	4
10	R:R:L600	7.25	4	4	9
11	R:R:E607	5.51	4	5	9
12	R:R:F610	6.38	5	0	8
13	R:R:Q618	2.95	4	0	7
14	R:R:R624	8.875	4	5	9
15	R:R:M627	3.8725	4	0	7
16	R:R:I636	4.255	4	0	7
17	R:R:D638	6.2375	4	0	7
18	R:R:W640	7.4175	4	0	6
19	R:R:V647	2.5725	4	0	5
20	R:R:F666	6.182	5	1	7
21	R:R:Y668	5.914	5	1	8
22	R:R:L669	5.4675	4	1	9
23	R:R:F672	6.436	5	0	9
24	R:R:F673	7.69	4	1	8
25	R:R:W674	13.76	5	2	9
26	R:R:L676	5.3775	4	0	7
27	R:R:M677	3.785	4	0	6
28	R:R:L678	4.65	4	0	8
29	R:R:Y707	8.2175	4	2	9
30	R:R:P710	5.7125	4	1	9
31	R:R:Y727	7.418	5	0	9
32	R:R:W734	6.61667	6	1	8
33	R:R:L735	7.135	4	0	9
34	R:R:P743	5.1825	4	6	8
35	R:R:L744	4.9675	4	1	8
36	R:R:F747	4.18	4	1	8
37	R:R:L800	8.4275	4	0	9
38	R:R:W804	8.94125	8	1	9
39	R:R:T810	4.2925	4	1	7
40	R:R:W819	13.045	4	0	6
41	R:R:H820	9.17667	6	1	8
42	R:R:F829	4.3	4	3	7
43	R:R:F832	4.8675	4	3	5
44	R:R:L835	4.45	4	0	8

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:S568	R:R:T567	27.2889	3.2	Yes	No	0	9	9
2	R:R:F582	R:R:V577	12.6081	7.87	No	Yes	0	1	3
3	R:R:T567	R:R:V732	29.8512	3.17	No	No	0	9	4
4	R:R:M573	R:R:W804	69.532	3.49	Yes	Yes	1	9	9
5	R:R:G807	R:R:M573	60.9613	3.49	No	Yes	0	9	9
6	R:R:G807	R:R:T810	59.8614	3.64	No	Yes	0	9	7
7	R:R:S574	R:R:T810	13.3647	3.2	Yes	Yes	1	9	7
8	R:R:S570	R:R:S574	18.4257	3.26	Yes	Yes	1	9	9
9	R:R:S568	R:R:S570	23.4613	6.52	Yes	Yes	1	9	9
10	R:R:H820	R:R:T810	39.0514	5.48	Yes	Yes	1	8	7
11	R:R:H820	R:R:V577	21.5221	9.69	Yes	Yes	1	8	3
12	R:R:L572	R:R:W734	26.3733	4.56	Yes	Yes	1	9	8
13	R:R:L735	R:R:W734	35.866	15.94	Yes	Yes	0	9	8
14	R:R:L735	R:R:L744	21.058	4.15	Yes	Yes	0	9	8
15	R:R:L744	R:R:P575	18.4321	3.28	Yes	No	1	8	6
16	R:R:P575	R:R:S574	18.7436	3.56	No	Yes	1	6	9
17	R:R:L572	R:R:W804	23.5885	6.83	Yes	Yes	1	9	9
18	R:R:F569	R:R:L593	10.6943	8.53	Yes	No	0	9	8
19	R:R:I571	R:R:V732	15.2785	4.61	No	No	0	7	4
20	R:R:I571	R:R:R729	10.1984	3.76	No	No	0	7	5
21	R:R:T810	R:R:W819	16.8171	4.85	Yes	Yes	0	7	6
22	R:R:I636	R:R:W640	39.6045	2.35	Yes	Yes	0	7	6
23	R:R:F667	R:R:I636	28.6432	7.54	No	Yes	0	8	7
24	R:R:F666	R:R:F667	29.4252	6.43	Yes	No	0	7	8
25	R:R:F662	R:R:F666	18.3113	3.22	No	Yes	1	8	7
26	R:R:F662	R:R:I718	17.9362	5.02	No	No	0	8	7
27	R:R:I718	R:R:Y727	17.2876	8.46	No	Yes	0	7	9
28	R:R:L735	R:R:Y727	26.0491	3.52	Yes	Yes	0	9	9
29	R:R:F666	R:R:S714	12.7607	5.28	Yes	No	1	7	9
30	R:R:H665	R:R:S714	13.7271	5.58	No	No	1	9	9
31	R:R:H665	R:R:W734	11.0122	4.23	No	Yes	1	9	8
32	R:R:F829	R:R:F832	13.7907	3.22	Yes	Yes	3	7	5
33	R:R:F832	R:R:F833	19.5766	5.36	Yes	No	0	5	7
34	R:R:F833	R:R:P798	28.6432	7.22	No	No	0	7	9
35	R:R:P798	R:R:T797	30.468	3.5	No	No	0	9	9
36	R:R:L802	R:R:T797	33.8759	11.79	No	No	0	7	9
37	R:R:L802	R:R:V762	39.1722	2.98	No	No	0	7	8
38	R:R:L796	R:R:V762	53.9229	5.96	No	No	0	9	8
39	R:R:L796	R:R:L800	55.576	6.92	No	Yes	0	9	9
40	R:R:L678	R:R:L800	60.4018	4.15	Yes	Yes	0	8	9
41	R:R:C626	R:R:L678	84.5117	4.76	No	Yes	0	7	8
42	R:R:C626	R:R:W674	85.3319	3.92	No	Yes	0	7	9
43	R:R:I630	R:R:W674	90.9016	3.52	No	Yes	0	8	9
44	R:R:I630	R:R:M675	91.868	7.29	No	No	0	8	9
45	R:R:L671	R:R:M675	93.8517	4.24	No	No	0	7	9
46	R:R:F672	R:R:L671	100	3.65	Yes	No	0	9	7
47	R:R:F672	R:R:W804	90.1704	14.03	Yes	Yes	0	9	9
48	R:R:D638	R:R:L593	10.9232	5.43	Yes	No	0	7	8
49	R:R:L600	R:R:L634	34.41	11.07	Yes	No	0	9	9
50	R:R:L634	R:R:L671	36.1584	4.15	No	No	0	9	7
51	R:R:I601	R:R:L635	33.8441	2.85	No	No	0	5	8
52	R:R:L600	R:R:L635	35.6879	8.3	Yes	No	0	9	8
53	R:R:C603	R:R:L835	19.5829	4.76	No	Yes	0	7	8
54	R:R:C603	R:R:I839	21.2297	3.27	No	No	0	7	7
55	R:R:I839	R:R:M627	55.5888	4.37	No	Yes	0	7	7
56	R:R:L799	R:R:M627	59.1874	5.65	No	Yes	0	6	7
57	R:R:L678	R:R:L799	60.5099	6.92	Yes	No	0	8	6
58	R:R:L835	R:R:L840	20.1233	1.38	Yes	No	0	8	7
59	R:R:L840	R:R:L849	20.7528	1.38	No	No	0	7	7
60	R:R:F610	R:R:L849	22.3741	7.31	Yes	No	0	8	7
61	R:R:F610	R:R:L609	29.5015	9.74	Yes	No	0	8	4
62	R:R:I605	R:R:L609	30.3026	2.85	No	No	0	6	4
63	R:R:I601	R:R:I605	31.339	2.94	No	No	0	5	6
64	R:R:E607	R:R:I839	55.2899	4.1	Yes	No	0	9	7
65	R:R:E607	R:R:W611	42.8535	4.36	Yes	No	5	9	9
66	R:R:H621	R:R:W611	41.5692	4.23	No	No	0	6	9
67	R:R:Q618	R:R:Q695	34.6516	6.4	Yes	No	0	7	6
68	R:R:H621	R:R:Q695	38.1358	8.65	No	No	0	6	6
69	R:R:M693	R:R:Y684	19.7673	7.18	No	No	0	5	8
70	R:R:M693	R:R:M698	21.7319	4.33	No	No	0	5	8
71	R:R:M698	R:R:Q618	27.3143	2.72	No	Yes	0	8	7
72	R:R:A660	R:R:G644	23.4168	1.95	No	No	0	7	6
73	R:R:A660	R:R:W640	25.1081	2.59	No	Yes	0	7	6
74	R:R:G644	R:R:V647	21.5348	3.68	No	Yes	0	6	5
75	R:R:T658	R:R:Y727	18.6165	3.75	No	Yes	0	6	9
76	R:R:V661	R:R:Y727	14.5282	12.62	No	Yes	0	8	9
77	R:R:V661	R:R:W734	15.7426	3.68	No	Yes	0	8	8
78	R:R:F747	R:R:W734	19.5575	4.01	Yes	Yes	1	8	8
79	R:R:F666	R:R:P710	13.7017	8.67	Yes	Yes	1	7	9
80	R:R:F673	R:R:P710	11.7434	7.22	Yes	Yes	1	8	9
81	R:R:F673	R:R:I754	18.7373	6.28	Yes	No	0	8	9
82	R:R:F672	R:R:I754	19.2141	5.02	Yes	No	0	9	9
83	R:R:A751	R:R:F672	22.2469	5.55	No	Yes	0	9	9
84	R:R:A751	R:R:F747	21.3377	4.16	No	Yes	0	9	8
85	R:R:I754	R:R:L676	25.8329	8.56	No	Yes	0	9	7
86	R:R:L682	R:R:V765	16.1114	4.47	No	No	0	9	9
87	R:R:V761	R:R:V765	16.9697	1.6	No	No	0	8	9
88	R:R:V757	R:R:V761	18.2922	1.6	No	No	0	7	8
89	R:R:L676	R:R:V757	19.2205	2.98	Yes	No	0	7	7
90	R:R:H691	R:R:Y684	14.0768	9.8	No	No	0	7	8
91	R:R:I687	R:R:L688	10.0585	2.85	No	No	0	6	6
92	R:R:H691	R:R:L688	12.074	7.71	No	No	0	7	6
93	R:R:T717	R:R:T721	11.0949	3.14	No	No	0	9	9
94	R:R:T721	R:R:Y727	12.8751	8.74	No	Yes	0	9	9
95	R:R:L735	R:R:P743	15.7236	4.93	Yes	Yes	0	9	8
96	R:R:D731	R:R:V732	10.2047	1.46	No	No	0	3	4
97	R:R:L766	R:R:V762	15.3039	4.47	No	No	0	7	8
98	R:R:I636	R:R:L635	34.7469	4.28	Yes	No	0	7	8
99	R:R:L678	R:R:L682	15.7045	2.77	Yes	No	0	8	9

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

there is no ligand in network 7WZ7_nogp

PDB Summary
PDB	7WZ7_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	3.17
Number of Linked Nodes	256
Number of Links	291
Number of Hubs	44
Number of Links mediated by Hubs	157
Number of Communities	6
Number of Nodes involved in Communities	45
Number of Links involved in Communities	63

Path Summary
Number Of Nodes in MetaPath	100
Number Of Links MetaPath	99
Number of Shortest Paths	43518
Length Of Smallest Path	3
Average Path Length	14.5149
Length of Longest Path	37
Minimum Path Strength	1.34
Average Path Strength	5.58778
Maximum Path Strength	19.755
Minimum Path Correlation	0.7
Average Path Correlation	0.923566
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	3.125
Average % Of Corr. Nodes	47.6157
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	42.5207
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function	• protein binding • binding • enzyme binding • GTPase binding • protein-containing complex binding • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • multicellular organismal process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development
Gene Ontology	Biological Process	• multicellular organismal process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development • anatomical structure development • sensory system development • system development • cell population proliferation • cellular process • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • signal transduction • cell communication • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • response to oxygen-containing compound • cellular response to oxygen-containing compound • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to chemical stimulus • cellular response to alcohol • response to hormone • response to chemical • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • small GTPase-mediated signal transduction • Ras protein signal transduction • intracellular signal transduction • intracellular signaling cassette • phospholipase C-activating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular response to nitrogen compound • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • response to nitrogen compound • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to monoamine stimulus • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • synaptic signaling • cellular response to acetylcholine • cell-cell signaling • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • cellular anatomical structure • membrane • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cell periphery • cytoplasmic side of plasma membrane • GTPase complex
Gene Ontology	Cellular Component	• cellular anatomical structure • membrane • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cell periphery • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • membrane-bounded organelle • extracellular vesicle • extracellular organelle • extracellular region • organelle • extracellular space • vesicle • extracellular membrane-bounded organelle • non-motile cilium • 9+0 non-motile cilium • cilium • neuron projection • photoreceptor disc membrane • photoreceptor outer segment • plasma membrane bounded cell projection • cell projection • photoreceptor cell cilium • organelle membrane • intracellular anatomical structure • cytoplasm • cytosol • vacuolar membrane • lytic vacuole • vacuole • intracellular membrane-bounded organelle • intracellular organelle • lytic vacuole membrane • bounding membrane of organelle • lysosomal membrane • lysosome • synapse • cell junction • molecular transducer activity • G protein-coupled receptor activity • transmembrane signaling receptor activity • signaling receptor activity • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cell communication • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular process • signal transduction • cell surface receptor signaling pathway • regulation of lipid metabolic process • primary metabolic process • metabolic process • regulation of metabolic process • lipid metabolic process • regulation of primary metabolic process • developmental process • fat cell differentiation • cellular developmental process • cell differentiation • behavior • multicellular organismal process • system process • learning or memory • nervous system process • cognition • memory • nervous system development • cellular component organization • cellular component biogenesis • multicellular organism development • cell junction organization • cellular component assembly • cell junction assembly • anatomical structure development • synapse organization • cellular component organization or biogenesis • synapse assembly • system development • energy derivation by oxidation of organic compounds • energy reserve metabolic process • generation of precursor metabolites and energy • plasma membrane bounded cell projection organization • cell projection organization • cell development • neuron projection development • generation of neurons • neurogenesis • neuron differentiation • neuron development • cytoplasmic vesicle • intracellular vesicle • protein binding • binding • G-protein beta-subunit binding • fibroblast proliferation • cell population proliferation • cellular response to nitrogen compound • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • response to oxygen-containing compound • response to nitrogen compound • cellular response to oxygen-containing compound • cellular response to chemical stimulus • cellular response to monoamine stimulus • response to chemical • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to alcohol • response to hormone • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus
SCOP2	Domain Identifier	• Transducin (heterotrimeric G protein), gamma chain
SCOP2	Family Identifier	• Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	Q5T601
Sequence	>7WZ7_nogp_Chain_R T S F S I L M S P F V P S T I F P V V K W I T Y V G L G I S I G S L I L C L I I E A L F W K Q K S Q T S H T R R I C M V N I A L S L L I A D V W F I V G A T V D T T V N P S G V C T A A V F F T H F F Y L S L F F W M L M L G I L L A Y R I I L V F H H M A Q H L M M A V G F C L G Y G C P L I I S V I T I A V T Q P S N T Y K R K D V C W L N W S N G S K P L L A F V V P A L A I V A V N F V V V L L V L T K L A T I I R V G K S L L I L T P L L G L T W G F G I G T I V D S Q N L A W H V I F A L L N A F Q G F F I L C F G I L L D S K L R Q L L F N K L S Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	8G2Y	B2	Adhesion	Adhesion	ADGRF1	Homo sapiens	-	LPC	chim(Gs-CtGq)/β1/γ2	3.44	2023-05-10	doi.org/10.1038/s41467-023-38083-7
	8G2Y (No Gprot)	B2	Adhesion	Adhesion	ADGRF1	Homo sapiens	-	LPC		3.44	2023-05-10	doi.org/10.1038/s41467-023-38083-7
	7WU3	B2	Adhesion	Adhesion	ADGRF1	Homo sapiens	-	K6G	Gs/β1/γ2	3.1	2022-04-27	doi.org/10.1038/s41586-022-04580-w
	7WU3 (No Gprot)	B2	Adhesion	Adhesion	ADGRF1	Homo sapiens	-	K6G		3.1	2022-04-27	doi.org/10.1038/s41586-022-04580-w
	7WU4	B2	Adhesion	Adhesion	ADGRF1	Homo sapiens	-	K6G	Gi1/β1/γ2	3.4	2022-04-27	doi.org/10.1038/s41586-022-04580-w
	7WU4 (No Gprot)	B2	Adhesion	Adhesion	ADGRF1	Homo sapiens	-	K6G		3.4	2022-04-27	doi.org/10.1038/s41586-022-04580-w
	7WU5	B2	Adhesion	Adhesion	ADGRF1	Homo sapiens	-	K6G	Gi1/β1/γ2	3	2022-04-27	doi.org/10.1038/s41586-022-04580-w
	7WU5 (No Gprot)	B2	Adhesion	Adhesion	ADGRF1	Homo sapiens	-	K6G		3	2022-04-27	doi.org/10.1038/s41586-022-04580-w
	7WXU	B2	Adhesion	Adhesion	ADGRF1	Homo sapiens	-	-	chim(NtGi1-Gs-CtGq)/β1/γ2	2.85	2022-09-28	doi.org/10.1038/s41467-022-33173-4
	7WXU (No Gprot)	B2	Adhesion	Adhesion	ADGRF1	Homo sapiens	-	-		2.85	2022-09-28	doi.org/10.1038/s41467-022-33173-4
	7WXW	B2	Adhesion	Adhesion	ADGRF1	Homo sapiens	-	-	chim(NtGi1-Gs)/β1/γ2	2.84	2022-09-28	doi.org/10.1038/s41467-022-33173-4
	7WXW (No Gprot)	B2	Adhesion	Adhesion	ADGRF1	Homo sapiens	-	-		2.84	2022-09-28	doi.org/10.1038/s41467-022-33173-4
	7WY0	B2	Adhesion	Adhesion	ADGRF1	Homo sapiens	-	-	chim(NtGi1L-G13)/β1/γ2	2.83	2022-09-28	doi.org/10.1038/s41467-022-33173-4
	7WY0 (No Gprot)	B2	Adhesion	Adhesion	ADGRF1	Homo sapiens	-	-		2.83	2022-09-28	doi.org/10.1038/s41467-022-33173-4
	7WZ7	B2	Adhesion	Adhesion	ADGRF1	Homo sapiens	-	-	chim(NtGi1-G12)/β1/γ2	2.83	2022-09-28	doi.org/10.1038/s41467-022-33173-4
	7WZ7 (No Gprot)	B2	Adhesion	Adhesion	ADGRF1	Homo sapiens	-	-		2.83	2022-09-28	doi.org/10.1038/s41467-022-33173-4
	7X2V	B2	Adhesion	Adhesion	ADGRF1	Homo sapiens	-	-	Gi1/β1/γ2	3.09	2022-09-28	doi.org/10.1038/s41467-022-33173-4
	7X2V (No Gprot)	B2	Adhesion	Adhesion	ADGRF1	Homo sapiens	-	-		3.09	2022-09-28	doi.org/10.1038/s41467-022-33173-4

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