psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:K586	R:R:T567	6.01	No	No	3	3	9
2	R:R:T567	R:R:Y590	12.48	No	Yes	3	9	5
3	R:R:S568	R:R:V585	8.08	No	No	0	9	8
4	R:R:F569	R:R:L572	3.65	Yes	No	0	9	9
5	R:R:F569	R:R:T589	3.89	Yes	No	0	9	9
6	R:R:F569	R:R:L593	3.65	Yes	Yes	0	9	8
7	R:R:F569	R:R:Y668	2.06	Yes	Yes	0	9	8
8	R:R:S570	R:R:S574	4.89	Yes	Yes	1	9	9
9	R:R:S570	R:R:T810	4.8	Yes	Yes	1	9	7
10	R:R:H820	R:R:S570	6.97	Yes	Yes	1	8	9
11	R:R:L572	R:R:W734	4.56	No	No	0	9	8
12	R:R:L572	R:R:W804	2.28	No	Yes	0	9	9
13	R:R:M573	R:R:V748	4.56	No	No	0	9	7
14	R:R:L752	R:R:M573	2.83	No	No	0	8	9
15	R:R:F823	R:R:M573	2.49	Yes	No	0	9	9
16	R:R:P575	R:R:S574	1.78	No	Yes	0	6	9
17	R:R:S574	R:R:V577	3.23	Yes	Yes	1	9	3
18	R:R:S574	R:R:T810	4.8	Yes	Yes	1	9	7
19	R:R:H820	R:R:S574	5.58	Yes	Yes	1	8	9
20	R:R:P575	R:R:W737	9.46	No	No	0	6	6
21	R:R:I811	R:R:P575	5.08	No	No	0	5	6
22	R:R:P578	R:R:V577	3.53	No	Yes	1	4	3
23	R:R:H820	R:R:V577	4.15	Yes	Yes	1	8	3
24	R:R:P578	R:R:S814	1.78	No	No	0	4	5
25	R:R:H820	R:R:P578	3.05	Yes	No	1	8	4
26	R:R:I581	R:R:V584	4.61	No	No	0	4	3
27	R:R:I581	R:R:Q815	16.47	No	No	0	4	3
28	R:R:H820	R:R:I581	2.65	Yes	No	0	8	4
29	R:R:K586	R:R:Y590	7.17	No	Yes	3	3	5
30	R:R:I588	R:R:L825	2.85	No	No	0	9	5
31	R:R:G592	R:R:V591	1.84	No	No	0	9	7
32	R:R:I595	R:R:V591	3.07	No	No	0	7	7
33	R:R:A828	R:R:G592	1.95	No	No	0	8	9
34	R:R:F829	R:R:G592	3.01	No	No	0	7	9
35	R:R:G594	R:R:L593	1.71	No	Yes	0	5	8
36	R:R:D638	R:R:L593	4.07	No	Yes	0	7	8
37	R:R:F641	R:R:L593	2.44	No	Yes	0	9	8
38	R:R:I642	R:R:L593	2.85	No	Yes	0	8	8
39	R:R:D638	R:R:S596	2.94	No	No	0	7	9
40	R:R:G598	R:R:I597	1.76	No	No	0	3	7
41	R:R:I597	R:R:L635	4.28	No	No	0	7	8
42	R:R:G598	R:R:I601	3.53	No	No	0	3	5
43	R:R:F832	R:R:S599	2.64	No	No	0	5	8
44	R:R:L835	R:R:S599	4.5	No	No	0	8	8
45	R:R:L600	R:R:L634	4.15	Yes	Yes	5	9	9
46	R:R:L600	R:R:L635	2.77	Yes	No	0	9	8
47	R:R:G831	R:R:L600	3.42	No	Yes	5	9	9
48	R:R:L602	R:R:L835	2.77	No	No	0	6	8
49	R:R:C603	R:R:L835	4.76	No	No	0	7	8
50	R:R:C603	R:R:I839	3.27	No	No	0	7	7
51	R:R:E607	R:R:I606	2.73	No	No	0	9	8
52	R:R:F610	R:R:I606	2.51	Yes	No	6	8	8
53	R:R:I606	R:R:L849	4.28	No	No	6	8	7
54	R:R:E607	R:R:R624	11.63	No	Yes	0	9	9
55	R:R:E607	R:R:I839	4.1	No	No	0	9	7
56	R:R:F610	R:R:L609	12.18	Yes	No	0	8	4
57	R:R:F610	R:R:L848	3.65	Yes	No	0	8	7
58	R:R:F610	R:R:L849	3.65	Yes	No	6	8	7
59	R:R:I614	R:R:W611	3.52	No	No	0	7	9
60	R:R:K612	R:R:Q613	8.14	No	No	0	7	5
61	R:R:L848	R:R:Q613	2.66	No	No	0	7	5
62	R:R:H621	R:R:K615	10.48	No	No	0	6	8
63	R:R:H692	R:R:Q618	2.47	No	No	0	6	7
64	R:R:Q618	R:R:Q695	10.24	No	No	0	7	6
65	R:R:M698	R:R:Q618	4.08	No	No	0	8	7
66	R:R:R685	R:R:T619	7.76	No	No	0	8	8
67	R:R:H621	R:R:Q695	12.36	No	No	8	6	6
68	R:R:H621	R:R:M699	2.63	No	No	8	6	7
69	R:R:L681	R:R:T622	5.9	No	No	0	7	7
70	R:R:R623	R:R:R624	3.2	No	Yes	7	9	9
71	R:R:M627	R:R:R623	3.72	Yes	No	7	7	9
72	R:R:M627	R:R:R624	3.72	Yes	Yes	7	7	9
73	R:R:L845	R:R:R624	3.64	No	Yes	0	8	9
74	R:R:I625	R:R:M699	4.37	No	No	0	7	7
75	R:R:C626	R:R:W674	2.61	No	Yes	0	7	9
76	R:R:C626	R:R:L678	3.17	No	No	0	7	8
77	R:R:L799	R:R:M627	2.83	No	Yes	0	6	7
78	R:R:G838	R:R:M627	1.75	No	Yes	0	8	7
79	R:R:N629	R:R:V628	2.96	Yes	No	0	9	7
80	R:R:N629	R:R:W674	20.34	Yes	Yes	2	9	9
81	R:R:F703	R:R:N629	3.62	No	Yes	2	8	9
82	R:R:N629	R:R:Y707	5.81	Yes	Yes	2	9	9
83	R:R:S633	R:R:S670	4.89	No	No	0	8	8
84	R:R:S633	R:R:Y707	3.82	No	Yes	0	8	9
85	R:R:D638	R:R:L634	4.07	No	Yes	0	7	9
86	R:R:L634	R:R:Q830	2.66	Yes	No	0	9	9
87	R:R:G831	R:R:L634	1.71	No	Yes	5	9	9
88	R:R:I636	R:R:W640	2.35	No	Yes	0	7	6
89	R:R:F667	R:R:I636	13.82	No	No	0	8	7
90	R:R:A637	R:R:Y668	9.34	No	Yes	0	9	8
91	R:R:F663	R:R:W640	16.04	No	Yes	0	8	6
92	R:R:G644	R:R:V643	1.84	No	No	0	6	8
93	R:R:V647	R:R:V656	3.21	No	No	0	5	5
94	R:R:D648	R:R:T650	14.45	No	No	0	5	3
95	R:R:C657	R:R:T649	3.38	No	No	0	9	3
96	R:R:N652	R:R:P653	4.89	No	No	0	4	4
97	R:R:G655	R:R:S654	3.71	No	No	0	3	4
98	R:R:C657	R:R:K728	8.08	No	No	0	9	5
99	R:R:C657	R:R:C733	7.28	No	No	0	9	9
100	R:R:Q722	R:R:T658	4.25	No	No	0	7	6
101	R:R:K728	R:R:T658	4.5	No	No	0	5	6
102	R:R:V661	R:R:Y727	7.57	No	Yes	0	8	9
103	R:R:C733	R:R:V661	1.71	No	No	0	9	8
104	R:R:F662	R:R:F663	6.43	Yes	No	0	8	8
105	R:R:F662	R:R:S714	3.96	Yes	No	0	8	9
106	R:R:F662	R:R:I718	5.02	Yes	No	9	8	7
107	R:R:F662	R:R:Y727	2.06	Yes	Yes	9	8	9
108	R:R:T664	R:R:Y668	2.5	No	Yes	0	7	8
109	R:R:T664	R:R:W734	7.28	No	No	0	7	8
110	R:R:H665	R:R:L669	2.57	Yes	Yes	0	9	9
111	R:R:H665	R:R:S714	4.18	Yes	No	0	9	9
112	R:R:H665	R:R:L735	2.57	Yes	No	0	9	9
113	R:R:F747	R:R:H665	3.39	No	Yes	0	8	9
114	R:R:F666	R:R:F667	9.65	Yes	No	0	7	8
115	R:R:F666	R:R:P710	4.33	Yes	Yes	0	7	9
116	R:R:F666	R:R:L711	4.87	Yes	No	0	7	7
117	R:R:F666	R:R:S714	5.28	Yes	No	0	7	9
118	R:R:F667	R:R:S670	2.64	No	No	0	8	8
119	R:R:F747	R:R:Y668	2.06	No	Yes	0	8	8
120	R:R:L669	R:R:P710	3.28	Yes	Yes	0	9	9
121	R:R:I713	R:R:L669	4.28	No	Yes	0	9	9
122	R:R:P710	R:R:S670	1.78	Yes	No	0	9	8
123	R:R:L671	R:R:M675	2.83	No	No	0	7	9
124	R:R:F672	R:R:M675	2.49	Yes	No	0	9	9
125	R:R:F672	R:R:F747	2.14	Yes	No	0	9	8
126	R:R:A751	R:R:F672	8.32	No	Yes	0	9	9
127	R:R:F672	R:R:W804	7.02	Yes	Yes	0	9	9
128	R:R:C709	R:R:F673	5.59	No	No	0	8	8
129	R:R:F673	R:R:I754	2.51	No	No	0	8	9
130	R:R:M677	R:R:W674	3.49	No	Yes	0	6	9
131	R:R:F703	R:R:W674	2	No	Yes	2	8	9
132	R:R:W674	R:R:Y707	9.65	Yes	Yes	2	9	9
133	R:R:G801	R:R:M675	1.75	No	No	0	9	9
134	R:R:I754	R:R:L676	2.85	No	No	0	9	7
135	R:R:L676	R:R:V757	2.98	No	No	0	7	7
136	R:R:G702	R:R:M677	1.75	No	No	0	7	6
137	R:R:L705	R:R:M677	4.24	No	No	0	6	6
138	R:R:G679	R:R:L678	1.71	No	No	0	9	8
139	R:R:G679	R:R:L800	1.71	No	No	0	9	9
140	R:R:I686	R:R:L682	2.85	No	No	0	7	9
141	R:R:R685	R:R:Y684	6.17	No	No	0	8	8
142	R:R:H691	R:R:Y684	4.36	No	No	0	7	8
143	R:R:M693	R:R:Y684	3.59	No	No	0	5	8
144	R:R:I686	R:R:K768	4.36	No	No	0	7	8
145	R:R:I687	R:R:L688	2.85	No	No	0	6	6
146	R:R:I687	R:R:L764	2.85	No	No	0	6	7
147	R:R:M693	R:R:M698	2.89	No	No	0	5	8
148	R:R:A694	R:R:H696	7.32	No	No	0	8	5
149	R:R:M699	R:R:Q695	4.08	No	No	8	7	6
150	R:R:G702	R:R:V701	1.84	No	No	0	7	6
151	R:R:C704	R:R:V701	1.71	No	No	0	4	6
152	R:R:F703	R:R:Y707	4.13	No	Yes	2	8	9
153	R:R:G708	R:R:P710	2.03	No	Yes	0	6	9
154	R:R:C709	R:R:P710	1.88	No	Yes	0	8	9
155	R:R:T717	R:R:Y727	2.5	No	Yes	0	9	9
156	R:R:P743	R:R:T717	1.75	Yes	No	0	8	9
157	R:R:I718	R:R:Y727	10.88	No	Yes	9	7	9
158	R:R:T721	R:R:T726	4.71	No	No	0	9	4
159	R:R:T721	R:R:Y727	2.5	No	Yes	0	9	9
160	R:R:P743	R:R:T721	3.5	Yes	No	0	8	9
161	R:R:P723	R:R:Q722	3.16	No	No	0	8	7
162	R:R:N725	R:R:Q722	2.64	No	No	0	4	7
163	R:R:S741	R:R:T726	4.8	No	No	0	8	4
164	R:R:D731	R:R:R729	3.57	No	No	10	3	5
165	R:R:R729	R:R:V732	3.92	No	No	10	5	4
166	R:R:N736	R:R:R729	2.41	No	No	0	8	5
167	R:R:D731	R:R:K730	4.15	No	No	0	3	2
168	R:R:D731	R:R:V732	5.84	No	No	10	3	4
169	R:R:L735	R:R:W734	9.11	No	No	0	9	8
170	R:R:N736	R:R:P743	3.26	No	Yes	0	8	8
171	R:R:K742	R:R:W737	17.4	No	No	0	7	6
172	R:R:P743	R:R:S741	1.78	Yes	No	0	8	8
173	R:R:L744	R:R:V748	2.98	No	No	0	8	7
174	R:R:P750	R:R:V749	5.3	No	No	0	9	7
175	R:R:L800	R:R:N758	12.36	No	No	0	9	9
176	R:R:L769	R:R:V765	2.98	No	No	0	7	9
177	R:R:L766	R:R:V789	2.98	No	No	0	7	8
178	R:R:L769	R:R:S792	3	No	No	0	7	8
179	R:R:T785	R:R:W770	4.85	No	No	0	7	6
180	R:R:P772	R:R:R771	2.88	No	No	0	7	8
181	R:R:P772	R:R:T785	1.75	No	No	0	7	7
182	R:R:I786	R:R:I787	2.94	No	No	0	6	4
183	R:R:I795	R:R:K791	2.91	No	No	0	7	8
184	R:R:I795	R:R:L841	2.85	No	No	0	7	5
185	R:R:P798	R:R:T797	3.5	Yes	No	0	9	9
186	R:R:L802	R:R:T797	2.95	No	No	0	7	9
187	R:R:F833	R:R:P798	2.89	No	Yes	0	7	9
188	R:R:F837	R:R:P798	2.89	Yes	Yes	0	8	9
189	R:R:L826	R:R:T803	5.9	No	No	0	6	9
190	R:R:N827	R:R:T803	5.85	No	No	0	9	9
191	R:R:F823	R:R:W804	2	Yes	Yes	4	9	9
192	R:R:N827	R:R:W804	7.91	No	Yes	4	9	9
193	R:R:F806	R:R:L826	2.44	No	No	0	8	6
194	R:R:G807	R:R:T810	3.64	No	Yes	0	9	7
195	R:R:F823	R:R:G807	3.01	Yes	No	0	9	9
196	R:R:G809	R:R:I808	1.76	No	No	0	7	7
197	R:R:G809	R:R:V812	1.84	No	No	0	7	6
198	R:R:G809	R:R:W819	2.81	No	Yes	0	7	6
199	R:R:T810	R:R:W819	2.43	Yes	Yes	1	7	6
200	R:R:H820	R:R:T810	8.21	Yes	Yes	1	8	7
201	R:R:D813	R:R:V812	2.92	No	No	0	4	6
202	R:R:D813	R:R:N816	16.16	No	No	1	4	5
203	R:R:D813	R:R:W819	6.7	No	Yes	1	4	6
204	R:R:N816	R:R:W819	14.69	No	Yes	1	5	6
205	R:R:L817	R:R:W819	6.83	No	Yes	0	2	6
206	R:R:A818	R:R:I822	3.25	No	No	0	6	5
207	R:R:F823	R:R:N827	19.33	Yes	No	4	9	9
208	R:R:F829	R:R:L825	4.87	No	No	0	7	5
209	R:R:F829	R:R:F833	3.22	No	No	0	7	7
210	R:R:I834	R:R:Q830	2.74	No	No	0	9	9
211	R:R:G831	R:R:I834	1.76	No	No	0	9	9
212	R:R:C836	R:R:F837	8.38	No	Yes	0	7	8
213	R:R:D842	R:R:S843	2.94	No	No	0	9	5
214	R:R:D842	R:R:L845	4.07	No	No	0	9	8
215	R:R:K844	R:R:L848	5.64	No	No	0	8	7
216	R:R:F850	R:R:R846	2.14	No	No	0	3	7
217	R:R:F850	R:R:L849	2.44	No	No	0	3	7
218	R:R:A660	R:R:V656	1.7	No	No	0	7	5
219	R:R:A818	R:R:V821	1.7	No	No	0	6	7
220	R:R:A746	R:R:T717	1.68	No	No	0	9	9
221	R:R:L669	R:R:P750	1.64	Yes	No	0	9	9
222	R:R:L799	R:R:P798	1.64	No	Yes	0	6	9
223	R:R:S568	R:R:S570	1.63	No	Yes	0	9	9
224	R:R:S617	R:R:S620	1.63	No	No	0	8	8
225	R:R:V584	R:R:V821	1.6	No	No	0	3	7
226	R:R:V585	R:R:V821	1.6	No	No	0	8	7
227	R:R:S617	R:R:T619	1.6	No	No	0	8	8
228	R:R:S654	R:R:T658	1.6	No	No	0	4	6
229	R:R:T650	R:R:V651	1.59	No	No	0	3	1
230	R:R:T785	R:R:V789	1.59	No	No	0	7	8
231	R:R:A631	R:R:L600	1.58	No	Yes	0	8	9
232	R:R:P798	R:R:Q830	1.58	Yes	No	0	9	9
233	R:R:I571	R:R:V577	1.54	No	Yes	0	7	3
234	R:R:I571	R:R:V732	1.54	No	No	0	7	4
235	R:R:I686	R:R:V765	1.54	No	No	0	7	9
236	R:R:I716	R:R:V720	1.54	No	No	0	7	5
237	R:R:M698	R:R:T622	1.51	No	No	0	8	7
238	R:R:F673	R:R:G706	1.51	No	No	0	8	9
239	R:R:L604	R:R:V628	1.49	No	No	0	8	7
240	R:R:N652	R:R:S654	1.49	No	No	0	4	4
241	R:R:L682	R:R:V761	1.49	No	No	0	9	8
242	R:R:L766	R:R:V762	1.49	No	Yes	0	7	8
243	R:R:L793	R:R:V762	1.49	No	Yes	0	7	8
244	R:R:L796	R:R:V762	1.49	No	Yes	0	9	8
245	R:R:L800	R:R:V762	1.49	No	Yes	0	9	8
246	R:R:L802	R:R:V762	1.49	No	Yes	0	7	8
247	R:R:I601	R:R:I605	1.47	No	No	0	5	6
248	R:R:I630	R:R:I834	1.47	No	No	0	8	9
249	R:R:I712	R:R:I716	1.47	No	No	0	5	7
250	R:R:F582	R:R:P583	1.44	No	No	0	1	1
251	R:R:I614	R:R:L845	1.43	No	No	0	7	8
252	R:R:I636	R:R:L632	1.43	No	No	0	7	5
253	R:R:I680	R:R:L676	1.43	No	No	0	8	7
254	R:R:I625	R:R:N629	1.42	No	Yes	0	7	9
255	R:R:K768	R:R:L764	1.41	No	No	0	8	7
256	R:R:A824	R:R:F569	1.39	No	Yes	0	8	9
257	R:R:K844	R:R:Q847	1.36	No	No	0	8	6
258	R:R:A645	R:R:Y590	1.33	No	Yes	0	7	5
259	R:R:F662	R:R:V715	1.31	Yes	No	0	8	6
260	R:R:A660	R:R:W640	1.3	No	Yes	0	7	6
261	R:R:H691	R:R:L688	1.29	No	No	0	7	6
262	R:R:H696	R:R:L697	1.29	No	No	0	5	3
263	R:R:T646	R:R:Y590	1.25	No	Yes	0	5	5
264	R:R:V639	R:R:W640	1.23	No	Yes	0	6	6
265	R:R:F837	R:R:L794	1.22	Yes	No	0	8	6
266	R:R:F837	R:R:L841	1.22	Yes	No	0	8	5
267	R:R:L769	R:R:R788	1.21	No	No	0	7	7

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	R:R:F569	2.928	5	0	9
2	R:R:S570	4.5725	4	1	9
3	R:R:S574	4.056	5	1	9
4	R:R:V577	3.1125	4	1	3
5	R:R:Y590	5.5575	4	3	5
6	R:R:L593	2.944	5	0	8
7	R:R:L600	2.98	4	5	9
8	R:R:F610	5.4975	4	6	8
9	R:R:R624	5.5475	4	7	9
10	R:R:M627	3.005	4	7	7
11	R:R:N629	6.83	5	2	9
12	R:R:L634	3.1475	4	5	9
13	R:R:W640	5.23	4	0	6
14	R:R:F662	3.756	5	9	8
15	R:R:H665	3.1775	4	0	9
16	R:R:F666	6.0325	4	0	7
17	R:R:Y668	3.99	4	0	8
18	R:R:L669	2.9425	4	0	9
19	R:R:F672	4.9925	4	0	9
20	R:R:W674	7.618	5	2	9
21	R:R:Y707	5.8525	4	2	9
22	R:R:P710	2.66	5	0	9
23	R:R:Y727	5.102	5	9	9
24	R:R:P743	2.5725	4	0	8
25	R:R:V762	1.49	5	0	8
26	R:R:P798	2.5	5	0	9
27	R:R:W804	4.8025	4	4	9
28	R:R:T810	4.776	5	1	7
29	R:R:W819	6.692	5	1	6
30	R:R:H820	5.10167	6	1	8
31	R:R:F823	6.7075	4	4	9
32	R:R:F837	3.4275	4	0	8

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:F569	R:R:L572	51.0511	3.65	Yes	No	0	9	9
2	R:R:L572	R:R:W804	50.7722	2.28	No	Yes	0	9	9
3	R:R:F823	R:R:W804	77.2415	2	Yes	Yes	4	9	9
4	R:R:F823	R:R:G807	71.7503	3.01	Yes	No	0	9	9
5	R:R:G807	R:R:T810	70.2703	3.64	No	Yes	0	9	7
6	R:R:S570	R:R:T810	11.9906	4.8	Yes	Yes	1	9	7
7	R:R:S568	R:R:S570	12.2801	1.63	No	Yes	0	9	9
8	R:R:F569	R:R:L593	100	3.65	Yes	Yes	0	9	8
9	R:R:F569	R:R:Y668	53.7323	2.06	Yes	Yes	0	9	8
10	R:R:F672	R:R:W804	44.7984	7.02	Yes	Yes	0	9	9
11	R:R:F672	R:R:F747	47.619	2.14	Yes	No	0	9	8
12	R:R:F747	R:R:Y668	54.7297	2.06	No	Yes	0	8	8
13	R:R:F823	R:R:M573	10.0815	2.49	Yes	No	0	9	9
14	R:R:P575	R:R:S574	11.0039	1.78	No	Yes	0	6	9
15	R:R:S574	R:R:V577	15.8837	3.23	Yes	Yes	1	9	3
16	R:R:H820	R:R:V577	17.0742	4.15	Yes	Yes	1	8	3
17	R:R:H820	R:R:I581	16.3878	2.65	Yes	No	0	8	4
18	R:R:F829	R:R:F833	18.0824	3.22	No	No	0	7	7
19	R:R:F833	R:R:P798	20.5813	2.89	No	Yes	0	7	9
20	R:R:P798	R:R:Q830	86.9584	1.58	Yes	No	0	9	9
21	R:R:L634	R:R:Q830	87.2158	2.66	Yes	No	0	9	9
22	R:R:D638	R:R:L634	93.9082	4.07	No	Yes	0	7	9
23	R:R:D638	R:R:L593	95.9245	4.07	No	Yes	0	7	8
24	R:R:F829	R:R:G592	10.4569	3.01	No	No	0	7	9
25	R:R:I597	R:R:L635	10.1137	4.28	No	No	0	7	8
26	R:R:L600	R:R:L635	12.6662	2.77	Yes	No	0	9	8
27	R:R:L600	R:R:L634	17.4818	4.15	Yes	Yes	5	9	9
28	R:R:C603	R:R:L835	10.4569	4.76	No	No	0	7	8
29	R:R:C603	R:R:I839	12.9558	3.27	No	No	0	7	7
30	R:R:E607	R:R:I839	15.2081	4.1	No	No	0	9	7
31	R:R:E607	R:R:R624	43.2003	11.63	No	Yes	0	9	9
32	R:R:M627	R:R:R624	55.7808	3.72	Yes	Yes	7	7	9
33	R:R:L799	R:R:M627	62.2051	2.83	No	Yes	0	6	7
34	R:R:L799	R:R:P798	64.275	1.64	No	Yes	0	6	9
35	R:R:E607	R:R:I606	27.3166	2.73	No	No	0	9	8
36	R:R:F610	R:R:I606	17.5461	2.51	Yes	No	6	8	8
37	R:R:F610	R:R:L848	12.6877	3.65	Yes	No	0	8	7
38	R:R:L845	R:R:R624	12.3552	3.64	No	Yes	0	8	9
39	R:R:I625	R:R:M699	71.761	4.37	No	No	0	7	7
40	R:R:I625	R:R:N629	74.2171	1.42	No	Yes	0	7	9
41	R:R:N629	R:R:Y707	56.0489	5.81	Yes	Yes	2	9	9
42	R:R:S633	R:R:Y707	88.9211	3.82	No	Yes	0	8	9
43	R:R:S633	R:R:S670	89.8112	4.89	No	No	0	8	8
44	R:R:P710	R:R:S670	63.4492	1.78	Yes	No	0	9	8
45	R:R:L669	R:R:P710	46.5144	3.28	Yes	Yes	0	9	9
46	R:R:H665	R:R:L669	50.2896	2.57	Yes	Yes	0	9	9
47	R:R:F747	R:R:H665	91.4629	3.39	No	Yes	0	8	9
48	R:R:Q618	R:R:Q695	62.1514	10.24	No	No	0	7	6
49	R:R:M699	R:R:Q695	64.1892	4.08	No	No	8	7	6
50	R:R:M698	R:R:Q618	57.3359	4.08	No	No	0	8	7
51	R:R:R685	R:R:Y684	11.8511	6.17	No	No	0	8	8
52	R:R:M693	R:R:Y684	46.9755	3.59	No	No	0	5	8
53	R:R:M693	R:R:M698	49.6675	2.89	No	No	0	5	8
54	R:R:C626	R:R:W674	47.4045	2.61	No	Yes	0	7	9
55	R:R:W674	R:R:Y707	30.1909	9.65	Yes	Yes	2	9	9
56	R:R:C626	R:R:L678	45.9996	3.17	No	No	0	7	8
57	R:R:F666	R:R:F667	28.9683	9.65	Yes	No	0	7	8
58	R:R:F666	R:R:S714	56.0275	5.28	Yes	No	0	7	9
59	R:R:H665	R:R:S714	49.0348	4.18	Yes	No	0	9	9
60	R:R:F662	R:R:S714	89.822	3.96	Yes	No	0	8	9
61	R:R:F662	R:R:F663	13.417	6.43	Yes	No	0	8	8
62	R:R:F663	R:R:W640	11.9155	16.04	No	Yes	0	8	6
63	R:R:C657	R:R:C733	40.3368	7.28	No	No	0	9	9
64	R:R:C733	R:R:V661	43.447	1.71	No	No	0	9	8
65	R:R:V661	R:R:Y727	46.9326	7.57	No	Yes	0	8	9
66	R:R:T717	R:R:Y727	29.1506	2.5	No	Yes	0	9	9
67	R:R:P743	R:R:T717	24.9678	1.75	Yes	No	0	8	9
68	R:R:N736	R:R:P743	40.991	3.26	No	Yes	0	8	8
69	R:R:N736	R:R:R729	36.583	2.41	No	No	0	8	5
70	R:R:R729	R:R:V732	26.7267	3.92	No	No	10	5	4
71	R:R:I571	R:R:V732	30.8022	1.54	No	No	0	7	4
72	R:R:I571	R:R:V577	31.006	1.54	No	Yes	0	7	3
73	R:R:T721	R:R:Y727	31.7675	2.5	No	Yes	0	9	9
74	R:R:P743	R:R:T721	24.9356	3.5	Yes	No	0	8	9
75	R:R:S654	R:R:T658	14.9614	1.6	No	No	0	4	6
76	R:R:K728	R:R:T658	29.5903	4.5	No	No	0	5	6
77	R:R:C657	R:R:K728	33.1939	8.08	No	No	0	9	5
78	R:R:Q722	R:R:T658	11.2505	4.25	No	No	0	7	6
79	R:R:F672	R:R:M675	10.3175	2.49	Yes	No	0	9	9
80	R:R:C709	R:R:P710	18.3076	1.88	No	Yes	0	8	9
81	R:R:C709	R:R:F673	15.755	5.59	No	No	0	8	8
82	R:R:F673	R:R:I754	10.5856	2.51	No	No	0	8	9
83	R:R:M677	R:R:W674	14.3501	3.49	No	Yes	0	6	9
84	R:R:G679	R:R:L678	44.6482	1.71	No	No	0	9	8
85	R:R:G679	R:R:L800	43.8117	1.71	No	No	0	9	9
86	R:R:L800	R:R:V762	43.4148	1.49	No	Yes	0	9	8
87	R:R:L802	R:R:V762	42.3638	1.49	No	Yes	0	7	8
88	R:R:L802	R:R:T797	43.3934	2.95	No	No	0	7	9
89	R:R:P798	R:R:T797	44.616	3.5	Yes	No	0	9	9
90	R:R:I686	R:R:K768	19.8734	4.36	No	No	0	7	8
91	R:R:K768	R:R:L764	22.7585	1.41	No	No	0	8	7
92	R:R:I687	R:R:L764	25.3754	2.85	No	No	0	6	7
93	R:R:I687	R:R:L688	28.2068	2.85	No	No	0	6	6
94	R:R:H691	R:R:L688	31.006	1.29	No	No	0	7	6
95	R:R:H691	R:R:Y684	33.7838	4.36	No	No	0	7	8
96	R:R:I686	R:R:V765	11.1218	1.54	No	No	0	7	9
97	R:R:L766	R:R:V762	17.3852	1.49	No	Yes	0	7	8
98	R:R:L766	R:R:V789	14.4037	2.98	No	No	0	7	8
99	R:R:T785	R:R:V789	11.7868	1.59	No	No	0	7	8
100	R:R:F837	R:R:P798	14.4037	2.89	Yes	Yes	0	8	9
101	R:R:T810	R:R:W819	25.4719	2.43	Yes	Yes	1	7	6
102	R:R:I581	R:R:V584	11.0039	4.61	No	No	0	4	3
103	R:R:S574	R:R:T810	20.828	4.8	Yes	Yes	1	9	7
104	R:R:H820	R:R:T810	28.9361	8.21	Yes	Yes	1	8	7
105	R:R:F662	R:R:Y727	80.3518	2.06	Yes	Yes	9	8	9
106	R:R:N629	R:R:W674	25.0107	20.34	Yes	Yes	2	9	9
107	R:R:F667	R:R:S670	29.9442	2.64	No	No	0	8	8
108	R:R:F666	R:R:P710	28.5929	4.33	Yes	Yes	0	7	9

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

there is no ligand in network 7WXU_nogp

PDB Summary
PDB	7WXU_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	1.71
Number of Linked Nodes	245
Number of Links	267
Number of Hubs	32
Number of Links mediated by Hubs	119
Number of Communities	10
Number of Nodes involved in Communities	37
Number of Links involved in Communities	44

Path Summary
Number Of Nodes in MetaPath	109
Number Of Links MetaPath	108
Number of Shortest Paths	31994
Length Of Smallest Path	3
Average Path Length	14.6522
Length of Longest Path	35
Minimum Path Strength	1.22
Average Path Strength	3.76655
Maximum Path Strength	13.43
Minimum Path Correlation	0.7
Average Path Correlation	0.930593
Maximum Path Correlation	1
Minimum % Of Corr. Nodes	3.125
Average % Of Corr. Nodes	48.2186
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	39.9888
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process	• cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cell communication • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular process • signal transduction • cell surface receptor signaling pathway • regulation of lipid metabolic process • primary metabolic process • metabolic process • regulation of metabolic process • lipid metabolic process • regulation of primary metabolic process • developmental process • fat cell differentiation • cellular developmental process • cell differentiation • behavior • multicellular organismal process • system process • learning or memory • nervous system process • cognition • memory • nervous system development • cellular component organization • cellular component biogenesis • multicellular organism development • cell junction organization • cellular component assembly • cell junction assembly • anatomical structure development • synapse organization • cellular component organization or biogenesis • synapse assembly • system development • energy derivation by oxidation of organic compounds • energy reserve metabolic process • generation of precursor metabolites and energy • plasma membrane bounded cell projection organization • cell projection organization • cell development • neuron projection development • generation of neurons • neurogenesis • neuron differentiation • neuron development • membrane-bounded organelle • intracellular organelle • cellular anatomical structure • intracellular anatomical structure • cytoplasmic vesicle • organelle • intracellular vesicle • cytoplasm • intracellular membrane-bounded organelle • vesicle • membrane • extracellular region • cell periphery • plasma membrane • protein binding • binding • G-protein beta-subunit binding • fibroblast proliferation • cell population proliferation • cellular response to nitrogen compound • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • response to oxygen-containing compound • response to nitrogen compound • cellular response to oxygen-containing compound • cellular response to chemical stimulus • cellular response to monoamine stimulus • response to chemical • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to alcohol • response to hormone • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • extracellular vesicle • extracellular organelle • extracellular space • extracellular membrane-bounded organelle • synapse • cell junction • enzyme binding • GTPase binding • protein-containing complex binding • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • sensory perception of chemical stimulus • sensory perception • sensory perception of taste • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • camera-type eye development • sensory system development • small GTPase-mediated signal transduction • Ras protein signal transduction • intracellular signal transduction • intracellular signaling cassette • phospholipase C-activating G protein-coupled receptor signaling pathway • synaptic signaling • cellular response to acetylcholine • cell-cell signaling • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • non-motile cilium • 9+0 non-motile cilium • cilium • neuron projection • photoreceptor disc membrane • photoreceptor outer segment • plasma membrane bounded cell projection • cell projection • photoreceptor cell cilium • organelle membrane • cytosol • vacuolar membrane • lytic vacuole • vacuole • lytic vacuole membrane • bounding membrane of organelle • lysosomal membrane • lysosome
Gene Ontology	Cellular Component
SCOP2	Domain Identifier	• Transducin (heterotrimeric G protein), gamma chain
SCOP2	Family Identifier	• Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	Q5T601
Sequence	>7WXU_nogp_Chain_R T S F S I L M S P F V P S T I F P V V K W I T Y V G L G I S I G S L I L C L I I E A L F W K Q I K K S Q T S H T R R I C M V N I A L S L L I A D V W F I V G A T V D T T V N P S G V C T A A V F F T H F F Y L S L F F W M L M L G I L L A Y R I I L V F H H M A Q H L M M A V G F C L G Y G C P L I I S V I T I A V T Q P S N T Y K R K D V C W L N W S N G S K P L L A F V V P A L A I V A V N F V V V L L V L T K L W R P A T I I R V G K S L L I L T P L L G L T W G F G I G T I V D S Q N L A W H V I F A L L N A F Q G F F I L C F G I L L D S K L R Q L L F N K L S Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	8G2Y	B2	Adhesion	Adhesion	ADGRF1	Homo sapiens	-	LPC	chim(Gs-CtGq)/β1/γ2	3.44	2023-05-10	doi.org/10.1038/s41467-023-38083-7
	8G2Y (No Gprot)	B2	Adhesion	Adhesion	ADGRF1	Homo sapiens	-	LPC		3.44	2023-05-10	doi.org/10.1038/s41467-023-38083-7
	7WU3	B2	Adhesion	Adhesion	ADGRF1	Homo sapiens	-	K6G	Gs/β1/γ2	3.1	2022-04-27	doi.org/10.1038/s41586-022-04580-w
	7WU3 (No Gprot)	B2	Adhesion	Adhesion	ADGRF1	Homo sapiens	-	K6G		3.1	2022-04-27	doi.org/10.1038/s41586-022-04580-w
	7WU4	B2	Adhesion	Adhesion	ADGRF1	Homo sapiens	-	K6G	Gi1/β1/γ2	3.4	2022-04-27	doi.org/10.1038/s41586-022-04580-w
	7WU4 (No Gprot)	B2	Adhesion	Adhesion	ADGRF1	Homo sapiens	-	K6G		3.4	2022-04-27	doi.org/10.1038/s41586-022-04580-w
	7WU5	B2	Adhesion	Adhesion	ADGRF1	Homo sapiens	-	K6G	Gi1/β1/γ2	3	2022-04-27	doi.org/10.1038/s41586-022-04580-w
	7WU5 (No Gprot)	B2	Adhesion	Adhesion	ADGRF1	Homo sapiens	-	K6G		3	2022-04-27	doi.org/10.1038/s41586-022-04580-w
	7WXU	B2	Adhesion	Adhesion	ADGRF1	Homo sapiens	-	-	chim(NtGi1-Gs-CtGq)/β1/γ2	2.85	2022-09-28	doi.org/10.1038/s41467-022-33173-4
	7WXU (No Gprot)	B2	Adhesion	Adhesion	ADGRF1	Homo sapiens	-	-		2.85	2022-09-28	doi.org/10.1038/s41467-022-33173-4
	7WXW	B2	Adhesion	Adhesion	ADGRF1	Homo sapiens	-	-	chim(NtGi1-Gs)/β1/γ2	2.84	2022-09-28	doi.org/10.1038/s41467-022-33173-4
	7WXW (No Gprot)	B2	Adhesion	Adhesion	ADGRF1	Homo sapiens	-	-		2.84	2022-09-28	doi.org/10.1038/s41467-022-33173-4
	7WY0	B2	Adhesion	Adhesion	ADGRF1	Homo sapiens	-	-	chim(NtGi1L-G13)/β1/γ2	2.83	2022-09-28	doi.org/10.1038/s41467-022-33173-4
	7WY0 (No Gprot)	B2	Adhesion	Adhesion	ADGRF1	Homo sapiens	-	-		2.83	2022-09-28	doi.org/10.1038/s41467-022-33173-4
	7WZ7	B2	Adhesion	Adhesion	ADGRF1	Homo sapiens	-	-	chim(NtGi1-G12)/β1/γ2	2.83	2022-09-28	doi.org/10.1038/s41467-022-33173-4
	7WZ7 (No Gprot)	B2	Adhesion	Adhesion	ADGRF1	Homo sapiens	-	-		2.83	2022-09-28	doi.org/10.1038/s41467-022-33173-4
	7X2V	B2	Adhesion	Adhesion	ADGRF1	Homo sapiens	-	-	Gi1/β1/γ2	3.09	2022-09-28	doi.org/10.1038/s41467-022-33173-4
	7X2V (No Gprot)	B2	Adhesion	Adhesion	ADGRF1	Homo sapiens	-	-		3.09	2022-09-28	doi.org/10.1038/s41467-022-33173-4

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