psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:K586	R:R:T567	4.5	No	No	0	3	9
2	R:R:T567	R:R:Y590	11.24	No	No	0	9	5
3	R:R:A645	R:R:T567	3.36	No	No	0	7	9
4	R:R:S568	R:R:S570	3.26	Yes	No	0	9	9
5	R:R:S568	R:R:V577	3.23	Yes	No	0	9	3
6	R:R:S568	R:R:V585	4.85	Yes	No	0	9	8
7	R:R:S568	R:R:T589	3.2	Yes	No	0	9	9
8	R:R:F569	R:R:L572	4.87	Yes	Yes	1	9	9
9	R:R:F569	R:R:T589	7.78	Yes	No	0	9	9
10	R:R:F569	R:R:L593	6.09	Yes	Yes	0	9	8
11	R:R:F569	R:R:Y668	4.13	Yes	Yes	1	9	8
12	R:R:F569	R:R:W804	3.01	Yes	Yes	1	9	9
13	R:R:A828	R:R:F569	4.16	No	Yes	0	8	9
14	R:R:S570	R:R:S574	4.89	No	No	2	9	9
15	R:R:H820	R:R:S570	4.18	Yes	No	2	8	9
16	R:R:F641	R:R:I571	2.51	No	No	0	9	7
17	R:R:I571	R:R:R729	8.77	No	No	0	7	5
18	R:R:I571	R:R:V732	4.61	No	No	0	7	4
19	R:R:F641	R:R:L572	7.31	No	Yes	0	9	9
20	R:R:L572	R:R:Y668	5.86	Yes	Yes	1	9	8
21	R:R:F747	R:R:L572	6.09	Yes	Yes	1	8	9
22	R:R:M573	R:R:V748	4.56	No	No	0	9	7
23	R:R:I811	R:R:M573	4.37	No	No	0	5	9
24	R:R:F823	R:R:M573	4.98	Yes	No	0	9	9
25	R:R:P575	R:R:S574	3.56	No	No	0	6	9
26	R:R:H820	R:R:S574	2.79	Yes	No	2	8	9
27	R:R:P575	R:R:W737	9.46	No	No	0	6	6
28	R:R:F576	R:R:P578	4.33	No	Yes	0	3	4
29	R:R:P578	R:R:V577	3.53	Yes	No	0	4	3
30	R:R:F582	R:R:V577	3.93	Yes	No	0	1	3
31	R:R:P578	R:R:T580	3.5	Yes	No	2	4	3
32	R:R:I581	R:R:P578	3.39	No	Yes	0	4	4
33	R:R:P578	R:R:Q815	11.05	Yes	No	2	4	3
34	R:R:H820	R:R:P578	3.05	Yes	Yes	2	8	4
35	R:R:F582	R:R:S579	3.96	Yes	No	0	1	3
36	R:R:Q815	R:R:T580	4.25	No	No	2	3	3
37	R:R:I581	R:R:V584	7.68	No	No	0	4	3
38	R:R:I581	R:R:V585	6.14	No	No	0	4	8
39	R:R:F582	R:R:K586	18.61	Yes	No	0	1	3
40	R:R:H820	R:R:V585	2.77	Yes	No	0	8	8
41	R:R:I588	R:R:W587	4.7	No	No	0	9	4
42	R:R:V591	R:R:W587	11.03	No	No	0	7	4
43	R:R:A824	R:R:I588	3.25	No	No	0	8	9
44	R:R:F829	R:R:G592	9.03	No	No	0	7	9
45	R:R:D638	R:R:L593	5.43	Yes	Yes	0	7	8
46	R:R:I642	R:R:L593	9.99	No	Yes	0	8	8
47	R:R:F832	R:R:I595	3.77	No	No	0	5	7
48	R:R:D638	R:R:S596	2.94	Yes	No	0	7	9
49	R:R:I597	R:R:L635	7.14	Yes	No	0	7	8
50	R:R:D638	R:R:I597	2.8	Yes	Yes	0	7	7
51	R:R:I597	R:R:V639	4.61	Yes	No	0	7	6
52	R:R:L835	R:R:S599	6.01	No	No	0	8	8
53	R:R:L600	R:R:L634	4.15	No	No	0	9	9
54	R:R:L600	R:R:L635	4.15	No	No	0	9	8
55	R:R:I601	R:R:I605	2.94	No	No	0	5	6
56	R:R:I601	R:R:L635	7.14	No	No	0	5	8
57	R:R:I606	R:R:L602	2.85	No	No	0	8	6
58	R:R:L602	R:R:L835	4.15	No	No	0	6	8
59	R:R:C603	R:R:I839	3.27	No	No	0	7	7
60	R:R:L604	R:R:V628	4.47	No	No	0	8	7
61	R:R:A631	R:R:L604	4.73	No	No	0	8	8
62	R:R:L604	R:R:L632	2.77	No	No	0	8	5
63	R:R:I606	R:R:L849	5.71	No	No	0	8	7
64	R:R:E607	R:R:W611	5.45	No	No	0	9	9
65	R:R:E607	R:R:R624	17.45	No	No	0	9	9
66	R:R:E607	R:R:V628	4.28	No	No	0	9	7
67	R:R:F610	R:R:L609	10.96	Yes	No	5	8	4
68	R:R:K852	R:R:L609	4.23	No	No	5	4	4
69	R:R:F610	R:R:L848	3.65	Yes	No	0	8	7
70	R:R:F610	R:R:L849	4.87	Yes	No	0	8	7
71	R:R:F610	R:R:K852	4.96	Yes	No	5	8	4
72	R:R:I614	R:R:W611	10.57	Yes	No	3	7	9
73	R:R:H621	R:R:W611	4.23	Yes	No	3	6	9
74	R:R:K612	R:R:Q613	4.07	No	No	0	7	5
75	R:R:H621	R:R:I614	5.3	Yes	Yes	3	6	7
76	R:R:I614	R:R:R624	5.01	Yes	No	0	7	9
77	R:R:K615	R:R:Q695	8.14	No	No	0	8	6
78	R:R:Q618	R:R:R685	3.5	No	No	6	7	8
79	R:R:H692	R:R:Q618	7.42	No	No	6	6	7
80	R:R:R685	R:R:T619	14.23	No	No	0	8	8
81	R:R:H621	R:R:I625	7.95	Yes	No	3	6	7
82	R:R:H621	R:R:Q695	11.13	Yes	No	0	6	6
83	R:R:H621	R:R:M699	3.94	Yes	No	3	6	7
84	R:R:L681	R:R:T622	2.95	No	No	0	7	7
85	R:R:M627	R:R:R623	8.69	No	No	0	7	9
86	R:R:L845	R:R:R624	8.5	No	No	0	8	9
87	R:R:I625	R:R:M699	4.37	No	No	3	7	7
88	R:R:F703	R:R:I625	2.51	No	No	0	8	7
89	R:R:C626	R:R:W674	5.22	No	Yes	4	7	9
90	R:R:C626	R:R:M677	3.24	No	No	4	7	6
91	R:R:I839	R:R:M627	2.92	No	No	0	7	7
92	R:R:N629	R:R:W674	32.77	No	Yes	4	9	9
93	R:R:F703	R:R:N629	6.04	No	No	0	8	9
94	R:R:N629	R:R:Y707	8.14	No	No	4	9	9
95	R:R:I630	R:R:W674	3.52	No	Yes	0	8	9
96	R:R:S633	R:R:S670	6.52	No	No	0	8	8
97	R:R:L671	R:R:S633	3	Yes	No	0	7	8
98	R:R:L634	R:R:L671	9.69	No	Yes	0	9	7
99	R:R:F667	R:R:I636	15.07	No	No	0	8	7
100	R:R:A637	R:R:Y668	4	No	Yes	0	9	8
101	R:R:D638	R:R:Y668	4.6	Yes	Yes	0	7	8
102	R:R:V643	R:R:W640	8.58	Yes	Yes	7	8	6
103	R:R:A660	R:R:W640	2.59	No	Yes	7	7	6
104	R:R:F663	R:R:W640	48.11	No	Yes	0	8	6
105	R:R:F641	R:R:T664	9.08	No	No	0	9	7
106	R:R:I642	R:R:T646	3.04	No	No	0	8	5
107	R:R:G644	R:R:V643	3.68	No	Yes	0	6	8
108	R:R:A660	R:R:V643	3.39	No	Yes	7	7	8
109	R:R:V647	R:R:V656	4.81	No	No	0	5	5
110	R:R:D648	R:R:T650	8.67	No	No	0	5	3
111	R:R:D648	R:R:V651	8.76	No	No	0	5	1
112	R:R:N652	R:R:P653	3.26	No	No	0	4	4
113	R:R:N652	R:R:V656	5.91	No	No	0	4	5
114	R:R:G655	R:R:S654	3.71	No	No	0	3	4
115	R:R:C657	R:R:C733	7.28	No	No	0	9	9
116	R:R:V661	R:R:Y727	10.09	No	Yes	0	8	9
117	R:R:L735	R:R:V661	2.98	Yes	No	0	9	8
118	R:R:F662	R:R:F663	7.5	No	No	0	8	8
119	R:R:F662	R:R:S714	2.64	No	No	0	8	9
120	R:R:F663	R:R:F667	3.22	No	No	0	8	8
121	R:R:T664	R:R:W734	8.49	No	No	0	7	8
122	R:R:H665	R:R:L669	7.71	Yes	No	0	9	9
123	R:R:H665	R:R:I713	2.65	Yes	No	0	9	9
124	R:R:H665	R:R:S714	4.18	Yes	No	0	9	9
125	R:R:H665	R:R:T717	2.74	Yes	No	0	9	9
126	R:R:H665	R:R:L735	2.57	Yes	Yes	0	9	9
127	R:R:A746	R:R:H665	2.93	No	Yes	0	9	9
128	R:R:F666	R:R:F667	9.65	Yes	No	0	7	8
129	R:R:F666	R:R:P710	4.33	Yes	Yes	0	7	9
130	R:R:F666	R:R:L711	8.53	Yes	No	0	7	7
131	R:R:F666	R:R:S714	7.93	Yes	No	0	7	9
132	R:R:L671	R:R:Y668	3.52	Yes	Yes	0	7	8
133	R:R:F747	R:R:Y668	10.32	Yes	Yes	1	8	8
134	R:R:W804	R:R:Y668	2.89	Yes	Yes	1	9	8
135	R:R:L669	R:R:P710	3.28	No	Yes	0	9	9
136	R:R:L669	R:R:P750	4.93	No	No	0	9	9
137	R:R:S670	R:R:Y707	2.54	No	No	0	8	9
138	R:R:P710	R:R:S670	3.56	Yes	No	0	9	8
139	R:R:F672	R:R:L671	7.31	No	Yes	0	9	7
140	R:R:A751	R:R:F672	8.32	No	No	0	9	9
141	R:R:F672	R:R:W804	19.04	No	Yes	0	9	9
142	R:R:C709	R:R:F673	4.19	No	No	0	8	8
143	R:R:F673	R:R:P710	4.33	No	Yes	0	8	9
144	R:R:M677	R:R:W674	6.98	No	Yes	4	6	9
145	R:R:G702	R:R:W674	2.81	No	Yes	0	7	9
146	R:R:G706	R:R:W674	9.85	No	Yes	0	9	9
147	R:R:W674	R:R:Y707	5.79	Yes	No	4	9	9
148	R:R:I680	R:R:L676	4.28	No	No	0	8	7
149	R:R:I754	R:R:L676	8.56	No	No	0	9	7
150	R:R:L705	R:R:M677	2.83	No	No	0	6	6
151	R:R:L678	R:R:L799	2.77	No	No	0	8	6
152	R:R:I686	R:R:L682	2.85	No	No	0	7	9
153	R:R:L682	R:R:V761	2.98	No	No	0	9	8
154	R:R:L682	R:R:V765	4.47	No	No	0	9	9
155	R:R:H691	R:R:Y684	8.71	No	No	0	7	8
156	R:R:H692	R:R:R685	3.39	No	No	6	6	8
157	R:R:I687	R:R:L764	2.85	No	No	0	6	7
158	R:R:F690	R:R:V689	9.18	No	No	0	8	9
159	R:R:H691	R:R:M693	6.57	No	No	0	7	5
160	R:R:M693	R:R:M698	4.33	No	No	0	5	8
161	R:R:A694	R:R:H696	4.39	No	No	0	8	5
162	R:R:L697	R:R:M698	4.24	No	No	0	3	8
163	R:R:L697	R:R:V701	2.98	No	No	0	3	6
164	R:R:L705	R:R:V701	2.98	No	No	0	6	6
165	R:R:I712	R:R:I716	2.94	No	No	0	5	7
166	R:R:I718	R:R:Y727	10.88	No	Yes	0	7	9
167	R:R:T721	R:R:T726	4.71	No	No	0	9	4
168	R:R:T721	R:R:Y727	6.24	No	Yes	0	9	9
169	R:R:S724	R:R:T726	3.2	No	No	0	3	4
170	R:R:K728	R:R:N725	6.99	No	No	0	5	4
171	R:R:S741	R:R:T726	9.59	No	No	0	8	4
172	R:R:N736	R:R:R729	14.46	No	No	0	8	5
173	R:R:D731	R:R:K730	17.97	No	No	0	3	2
174	R:R:L735	R:R:W734	14.81	Yes	No	1	9	8
175	R:R:L744	R:R:W734	5.69	No	No	1	8	8
176	R:R:L735	R:R:P743	13.14	Yes	No	0	9	8
177	R:R:L735	R:R:L744	5.54	Yes	No	1	9	8
178	R:R:N739	R:R:S738	2.98	No	No	0	4	2
179	R:R:K742	R:R:L745	4.23	No	No	0	7	8
180	R:R:F747	R:R:L744	3.65	Yes	No	1	8	8
181	R:R:A751	R:R:F747	4.16	No	Yes	0	9	8
182	R:R:P750	R:R:V749	3.53	No	No	0	9	7
183	R:R:I754	R:R:N758	4.25	No	No	0	9	9
184	R:R:N758	R:R:V757	2.96	No	No	0	9	7
185	R:R:L800	R:R:N758	16.48	Yes	No	0	9	9
186	R:R:F759	R:R:L763	7.31	No	No	0	4	4
187	R:R:F759	R:R:L802	4.87	No	No	0	4	7
188	R:R:L766	R:R:V762	2.98	No	No	0	7	8
189	R:R:L796	R:R:V762	4.47	No	No	0	9	8
190	R:R:L766	R:R:V789	5.96	No	No	0	7	8
191	R:R:L766	R:R:S792	3	No	No	0	7	8
192	R:R:K768	R:R:T767	3	No	No	0	8	4
193	R:R:L769	R:R:R788	4.86	No	No	0	7	7
194	R:R:P772	R:R:W770	9.46	No	Yes	8	7	6
195	R:R:T785	R:R:W770	9.7	No	Yes	8	7	6
196	R:R:P772	R:R:T785	5.25	No	No	8	7	7
197	R:R:A784	R:R:I787	6.5	No	No	0	6	4
198	R:R:I787	R:R:K791	5.82	No	No	0	4	8
199	R:R:L793	R:R:T797	2.95	No	Yes	0	7	9
200	R:R:F837	R:R:L794	8.53	No	No	0	8	6
201	R:R:I795	R:R:L841	7.14	No	No	0	7	5
202	R:R:L796	R:R:L800	5.54	No	Yes	0	9	9
203	R:R:P798	R:R:T797	3.5	No	Yes	0	9	9
204	R:R:L802	R:R:T797	5.9	No	Yes	0	7	9
205	R:R:F833	R:R:P798	8.67	No	No	0	7	9
206	R:R:L799	R:R:L800	2.77	No	Yes	0	6	9
207	R:R:I834	R:R:L799	4.28	No	No	0	9	6
208	R:R:F806	R:R:T803	2.59	Yes	Yes	1	8	9
209	R:R:L826	R:R:T803	4.42	No	Yes	1	6	9
210	R:R:N827	R:R:T803	8.77	Yes	Yes	1	9	9
211	R:R:F823	R:R:W804	3.01	Yes	Yes	1	9	9
212	R:R:N827	R:R:W804	13.56	Yes	Yes	1	9	9
213	R:R:Q830	R:R:W804	14.24	No	Yes	0	9	9
214	R:R:F806	R:R:W819	3.01	Yes	No	1	8	6
215	R:R:F806	R:R:I822	5.02	Yes	No	1	8	5
216	R:R:F806	R:R:F823	3.22	Yes	Yes	1	8	9
217	R:R:F806	R:R:L826	9.74	Yes	No	1	8	6
218	R:R:F806	R:R:N827	3.62	Yes	Yes	1	8	9
219	R:R:F823	R:R:G807	6.02	Yes	No	0	9	9
220	R:R:I808	R:R:I811	2.94	No	No	0	7	5
221	R:R:H820	R:R:T810	9.58	Yes	No	0	8	7
222	R:R:D813	R:R:S814	2.94	No	No	0	4	5
223	R:R:D813	R:R:N816	10.77	No	No	0	4	5
224	R:R:N816	R:R:W819	4.52	No	No	0	5	6
225	R:R:I822	R:R:W819	10.57	No	No	1	5	6
226	R:R:F823	R:R:N827	16.92	Yes	Yes	1	9	9
227	R:R:L825	R:R:L826	4.15	No	No	0	5	6
228	R:R:A828	R:R:F829	2.77	No	No	0	8	7
229	R:R:C836	R:R:F832	5.59	No	No	0	7	5
230	R:R:I839	R:R:L840	2.85	No	No	0	7	7
231	R:R:D842	R:R:L845	12.21	No	No	0	9	8
232	R:R:R846	R:R:S843	5.27	No	No	0	7	5
233	R:R:K844	R:R:L848	5.64	No	No	0	8	7
234	R:R:F850	R:R:R846	3.21	No	No	0	3	7
235	R:R:N851	R:R:Q847	11.88	No	No	0	4	6
236	R:R:F850	R:R:S854	2.64	No	No	0	3	5
237	R:R:T658	R:R:Y727	2.5	No	Yes	0	6	9
238	R:R:V789	R:R:W770	2.45	No	Yes	0	8	6
239	R:R:L678	R:R:R623	2.43	No	No	0	8	9
240	R:R:L681	R:R:R623	2.43	No	No	0	7	9
241	R:R:I786	R:R:W770	2.35	No	Yes	0	6	6
242	R:R:K742	R:R:W737	2.32	No	No	0	7	6
243	R:R:F833	R:R:F837	2.14	No	No	0	7	8
244	R:R:G708	R:R:P710	2.03	No	Yes	0	6	9
245	R:R:C733	R:R:G644	1.96	No	No	0	9	6
246	R:R:G831	R:R:S596	1.86	No	No	0	9	9
247	R:R:G592	R:R:V591	1.84	No	No	0	9	7
248	R:R:G679	R:R:V761	1.84	No	No	0	9	8
249	R:R:G809	R:R:V812	1.84	No	No	0	7	6
250	R:R:A631	R:R:C603	1.81	No	No	0	8	7
251	R:R:G598	R:R:I597	1.76	No	Yes	0	3	7
252	R:R:G838	R:R:I795	1.76	No	No	0	8	7
253	R:R:G809	R:R:I808	1.76	No	No	0	7	7
254	R:R:G838	R:R:M627	1.75	No	No	0	8	7
255	R:R:G801	R:R:M675	1.75	No	No	0	9	9
256	R:R:G594	R:R:L593	1.71	No	Yes	0	5	8
257	R:R:G679	R:R:L678	1.71	No	No	0	9	8
258	R:R:G679	R:R:L800	1.71	No	Yes	0	9	9
259	R:R:G805	R:R:L752	1.71	No	No	0	6	8
260	R:R:A683	R:R:V761	1.7	No	No	0	6	8
261	R:R:C733	R:R:T649	1.69	No	No	0	9	3
262	R:R:S617	R:R:S620	1.63	No	No	0	8	8
263	R:R:A683	R:R:I687	1.62	No	No	0	6	6
264	R:R:V584	R:R:V821	1.6	No	No	0	3	7
265	R:R:S617	R:R:T619	1.6	No	No	0	8	8
266	R:R:V643	R:R:V647	1.6	Yes	No	0	8	5
267	R:R:C704	R:R:L705	1.59	No	No	0	4	6
268	R:R:P723	R:R:Q722	1.58	No	No	0	8	7
269	R:R:T649	R:R:T650	1.57	No	No	0	3	3
270	R:R:T797	R:R:T803	1.57	Yes	Yes	0	9	9
271	R:R:I595	R:R:S599	1.55	No	No	0	7	8
272	R:R:I614	R:R:S620	1.55	Yes	No	0	7	8
273	R:R:L752	R:R:V748	1.49	No	No	0	8	7
274	R:R:L752	R:R:V755	1.49	No	No	0	8	8
275	R:R:L802	R:R:V755	1.49	No	No	0	7	8
276	R:R:L769	R:R:V765	1.49	No	No	0	7	9
277	R:R:I630	R:R:M675	1.46	No	No	0	8	9
278	R:R:D731	R:R:V732	1.46	No	No	0	3	4
279	R:R:I686	R:R:K768	1.45	No	No	0	7	8
280	R:R:F582	R:R:P583	1.44	Yes	No	0	1	1
281	R:R:P772	R:R:R771	1.44	No	No	0	7	8
282	R:R:Q722	R:R:T658	1.42	No	No	0	7	6
283	R:R:K852	R:R:L853	1.41	No	No	0	4	4
284	R:R:C836	R:R:F837	1.4	No	No	0	7	8
285	R:R:L817	R:R:N816	1.37	No	No	0	2	5
286	R:R:N725	R:R:Q722	1.32	No	No	0	4	7
287	R:R:A659	R:R:W640	1.3	No	Yes	0	7	6

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	R:R:S568	3.635	4	0	9
2	R:R:F569	5.00667	6	1	9
3	R:R:L572	6.0325	4	1	9
4	R:R:P578	4.80833	6	2	4
5	R:R:F582	6.985	4	0	1
6	R:R:L593	5.805	4	0	8
7	R:R:I597	4.0775	4	0	7
8	R:R:F610	6.11	4	5	8
9	R:R:I614	5.6075	4	3	7
10	R:R:H621	6.51	5	3	6
11	R:R:D638	3.9425	4	0	7
12	R:R:W640	15.145	4	7	6
13	R:R:V643	4.3125	4	7	8
14	R:R:H665	3.79667	6	0	9
15	R:R:F666	7.61	4	0	7
16	R:R:Y668	5.04571	7	1	8
17	R:R:L671	5.88	4	0	7
18	R:R:W674	9.56286	7	4	9
19	R:R:P710	3.506	5	0	9
20	R:R:Y727	7.4275	4	0	9
21	R:R:L735	7.808	5	1	9
22	R:R:F747	6.055	4	1	8
23	R:R:W770	5.99	4	8	6
24	R:R:T797	3.48	4	0	9
25	R:R:L800	6.625	4	0	9
26	R:R:T803	4.3375	4	1	9
27	R:R:W804	9.29167	6	1	9
28	R:R:F806	4.53333	6	1	8
29	R:R:H820	4.474	5	2	8
30	R:R:F823	6.83	5	1	9
31	R:R:N827	10.7175	4	1	9

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:F582	R:R:V577	10.2907	3.93	Yes	No	0	1	3
2	R:R:S568	R:R:V577	16.7498	3.23	Yes	No	0	9	3
3	R:R:S568	R:R:S570	11.082	3.26	Yes	No	0	9	9
4	R:R:S568	R:R:T589	36.8883	3.2	Yes	No	0	9	9
5	R:R:F569	R:R:T589	38.1397	7.78	Yes	No	0	9	9
6	R:R:F569	R:R:L572	11.3443	4.87	Yes	Yes	1	9	9
7	R:R:F569	R:R:Y668	31.0914	4.13	Yes	Yes	1	9	8
8	R:R:F569	R:R:W804	12.6946	3.01	Yes	Yes	1	9	9
9	R:R:A828	R:R:F569	10.2004	4.16	No	Yes	0	8	9
10	R:R:F747	R:R:Y668	21.5189	10.32	Yes	Yes	1	8	8
11	R:R:F823	R:R:W804	31.8698	3.01	Yes	Yes	1	9	9
12	R:R:F823	R:R:M573	15.5414	4.98	Yes	No	0	9	9
13	R:R:D638	R:R:Y668	11.8345	4.6	Yes	Yes	0	7	8
14	R:R:C836	R:R:F832	22.6585	5.59	No	No	0	7	5
15	R:R:C836	R:R:F837	24.37	1.4	No	No	0	7	8
16	R:R:F833	R:R:F837	27.5307	2.14	No	No	0	7	8
17	R:R:F833	R:R:P798	29.2165	8.67	No	No	0	7	9
18	R:R:P798	R:R:T797	30.8936	3.5	No	Yes	0	9	9
19	R:R:T797	R:R:T803	39.9372	1.57	Yes	Yes	0	9	9
20	R:R:N827	R:R:T803	43.1109	8.77	Yes	Yes	1	9	9
21	R:R:N827	R:R:W804	58.39	13.56	Yes	Yes	1	9	9
22	R:R:F832	R:R:I595	20.9383	3.77	No	No	0	5	7
23	R:R:I595	R:R:S599	19.2096	1.55	No	No	0	7	8
24	R:R:L835	R:R:S599	17.4723	6.01	No	No	0	8	8
25	R:R:L671	R:R:Y668	65.9112	3.52	Yes	Yes	0	7	8
26	R:R:I606	R:R:L602	13.9675	2.85	No	No	0	8	6
27	R:R:L602	R:R:L835	15.7263	4.15	No	No	0	6	8
28	R:R:A631	R:R:C603	68.8183	1.81	No	No	0	8	7
29	R:R:A631	R:R:L604	69.8073	4.73	No	No	0	8	8
30	R:R:L604	R:R:V628	71.7597	4.47	No	No	0	8	7
31	R:R:E607	R:R:V628	72.6972	4.28	No	No	0	9	7
32	R:R:E607	R:R:W611	71.2178	5.45	No	No	0	9	9
33	R:R:H621	R:R:W611	70.1944	4.23	Yes	No	3	6	9
34	R:R:H621	R:R:I625	83.4136	7.95	Yes	No	3	6	7
35	R:R:F703	R:R:I625	85.3144	2.51	No	No	0	8	7
36	R:R:F703	R:R:N629	86.1744	6.04	No	No	0	8	9
37	R:R:N629	R:R:Y707	81.5215	8.14	No	No	4	9	9
38	R:R:S670	R:R:Y707	98.5895	2.54	No	No	0	8	9
39	R:R:S633	R:R:S670	99.7463	6.52	No	No	0	8	8
40	R:R:L671	R:R:S633	100	3	Yes	No	0	7	8
41	R:R:C603	R:R:I839	67.8163	3.27	No	No	0	7	7
42	R:R:I606	R:R:L849	12.3291	5.71	No	No	0	8	7
43	R:R:H621	R:R:I614	11.0347	5.3	Yes	Yes	3	6	7
44	R:R:F610	R:R:L849	10.7938	4.87	Yes	No	0	8	7
45	R:R:I839	R:R:M627	65.8639	2.92	No	No	0	7	7
46	R:R:M627	R:R:R623	61.8044	8.69	No	No	0	7	9
47	R:R:W674	R:R:Y707	16.4402	5.79	Yes	No	4	9	9
48	R:R:M677	R:R:W674	12.514	6.98	No	Yes	4	6	9
49	R:R:F666	R:R:F667	22.3488	9.65	Yes	No	0	7	8
50	R:R:F666	R:R:P710	25.3161	4.33	Yes	Yes	0	7	9
51	R:R:P710	R:R:S670	41.5971	3.56	Yes	No	0	9	8
52	R:R:F747	R:R:L744	28.2274	3.65	Yes	No	1	8	8
53	R:R:L735	R:R:L744	26.9201	5.54	Yes	No	1	9	8
54	R:R:H665	R:R:L735	26.9416	2.57	Yes	Yes	0	9	9
55	R:R:H665	R:R:S714	14.8835	4.18	Yes	No	0	9	9
56	R:R:F662	R:R:S714	14.0922	2.64	No	No	0	8	9
57	R:R:F662	R:R:F663	12.8709	7.5	No	No	0	8	8
58	R:R:F663	R:R:W640	30.6356	48.11	No	Yes	0	8	6
59	R:R:V643	R:R:W640	24.6108	8.58	Yes	Yes	7	8	6
60	R:R:F663	R:R:F667	19.7514	3.22	No	No	0	8	8
61	R:R:G644	R:R:V643	14.5351	3.68	No	Yes	0	6	8
62	R:R:C733	R:R:G644	12.4839	1.96	No	No	0	9	6
63	R:R:L735	R:R:V661	15.6231	2.98	Yes	No	0	9	8
64	R:R:V661	R:R:Y727	14.5136	10.09	No	Yes	0	8	9
65	R:R:H665	R:R:L669	11.512	7.71	Yes	No	0	9	9
66	R:R:L669	R:R:P710	12.8021	3.28	No	Yes	0	9	9
67	R:R:F672	R:R:W804	33.2631	19.04	No	Yes	0	9	9
68	R:R:L800	R:R:N758	13.3912	16.48	Yes	No	0	9	9
69	R:R:L799	R:R:L800	20.3965	2.77	No	Yes	0	6	9
70	R:R:L678	R:R:L799	22.8305	2.77	No	No	0	8	6
71	R:R:L678	R:R:R623	58.6953	2.43	No	No	0	8	9
72	R:R:G679	R:R:L800	21.0458	1.71	No	Yes	0	9	9
73	R:R:G679	R:R:L678	34.9875	1.71	No	No	0	9	8
74	R:R:L705	R:R:M677	11.1723	2.83	No	No	0	6	6
75	R:R:G679	R:R:V761	14.419	1.84	No	No	0	9	8
76	R:R:L796	R:R:L800	25.7074	5.54	No	Yes	0	9	9
77	R:R:L796	R:R:V762	23.0799	4.47	No	No	0	9	8
78	R:R:L766	R:R:V762	20.7319	2.98	No	No	0	7	8
79	R:R:L766	R:R:V789	15.7392	5.96	No	No	0	7	8
80	R:R:V789	R:R:W770	13.3783	2.45	No	Yes	0	8	6
81	R:R:F806	R:R:F823	15.4812	3.22	Yes	Yes	1	8	9
82	R:R:F806	R:R:N827	14.4706	3.62	Yes	Yes	1	8	9
83	R:R:F806	R:R:W819	16.8745	3.01	Yes	No	1	8	6
84	R:R:N816	R:R:W819	13.5332	4.52	No	No	0	5	6
85	R:R:W804	R:R:Y668	47.8928	2.89	Yes	Yes	1	9	8
86	R:R:F672	R:R:L671	33.4351	7.31	No	Yes	0	9	7

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

there is no ligand in network 7X2V_nogp

PDB Summary
PDB	7X2V_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	2.51
Number of Linked Nodes	264
Number of Links	287
Number of Hubs	31
Number of Links mediated by Hubs	120
Number of Communities	8
Number of Nodes involved in Communities	43
Number of Links involved in Communities	54

Path Summary
Number Of Nodes in MetaPath	87
Number Of Links MetaPath	86
Number of Shortest Paths	48819
Length Of Smallest Path	3
Average Path Length	17.4197
Length of Longest Path	46
Minimum Path Strength	1.37
Average Path Strength	5.51765
Maximum Path Strength	28.345
Minimum Path Correlation	0.7
Average Path Correlation	0.933783
Maximum Path Correlation	1
Minimum % Of Corr. Nodes	2.43902
Average % Of Corr. Nodes	49.6326
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	33.8756
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process	• fibroblast proliferation • cell population proliferation • cellular process • cellular response to nitrogen compound • cellular response to stimulus • response to dopamine • regulation of cellular process • response to stimulus • signaling • cellular response to dopamine • response to monoamine • cell communication • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • signal transduction • regulation of biological process • G protein-coupled dopamine receptor signaling pathway • biological regulation • response to oxygen-containing compound • response to nitrogen compound • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to oxygen-containing compound • cellular response to chemical stimulus • cellular response to monoamine stimulus • response to chemical • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to alcohol • response to hormone • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • cellular anatomical structure • membrane • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cell periphery • cytoplasmic side of plasma membrane • GTPase complex
Gene Ontology	Cellular Component	• cellular anatomical structure • membrane • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cell periphery • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • membrane-bounded organelle • extracellular vesicle • extracellular organelle • extracellular region • organelle • extracellular space • vesicle • extracellular membrane-bounded organelle • synapse • cell junction • D2 dopamine receptor binding • protein binding • binding • signaling receptor binding • G protein-coupled receptor binding • dopamine receptor binding • phosphorus-oxygen lyase activity • enzyme regulator activity • cyclase regulator activity • molecular function regulator activity • cyclase activity • adenylate cyclase regulator activity • lyase activity • catalytic activity • adenylate cyclase activity • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • cation binding • magnesium ion binding • metal ion binding • GDP binding • G protein-coupled serotonin receptor binding • protein-containing complex binding • G-protein beta/gamma-subunit complex binding • pyrophosphatase activity • GTPase activity • G protein activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • adenylate cyclase-inhibiting serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • cell communication • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular process • signal transduction • response to hormone • response to chemical • response to endogenous stimulus • response to peptide hormone • response to oxygen-containing compound • response to nitrogen compound • cell division • leukocyte migration • immune system process • mononuclear cell migration • lymphocyte migration • cell migration • T cell migration • cell motility • regulation of steroid biosynthetic process • regulation of cholesterol biosynthetic process • regulation of cholesterol metabolic process • steroid metabolic process • regulation of lipid metabolic process • sterol metabolic process • positive regulation of biological process • cholesterol metabolic process • lipid biosynthetic process • alcohol metabolic process • regulation of primary metabolic process • positive regulation of metabolic process • regulation of small molecule metabolic process • positive regulation of biosynthetic process • positive regulation of lipid metabolic process • small molecule metabolic process • steroid biosynthetic process • positive regulation of cellular process • regulation of biosynthetic process • secondary alcohol biosynthetic process • regulation of alcohol biosynthetic process • small molecule biosynthetic process • regulation of steroid metabolic process • cholesterol biosynthetic process • positive regulation of cholesterol biosynthetic process • primary metabolic process • secondary alcohol metabolic process • positive regulation of steroid biosynthetic process • biosynthetic process • sterol biosynthetic process • positive regulation of lipid biosynthetic process • regulation of sterol biosynthetic process • alcohol biosynthetic process • positive regulation of cholesterol metabolic process • positive regulation of steroid metabolic process • metabolic process • regulation of lipid biosynthetic process • positive regulation of small molecule metabolic process • regulation of metabolic process • positive regulation of alcohol biosynthetic process • positive regulation of sterol biosynthetic process • lipid metabolic process • regulation of cytoskeleton organization • regulation of cellular component organization • microtubule cytoskeleton organization • regulation of mitotic spindle organization • mitotic cell cycle • cellular component organization • cell cycle • cellular component organization or biogenesis • regulation of cell cycle • microtubule cytoskeleton organization involved in mitosis • spindle organization • cell cycle process • regulation of cell cycle process • regulation of microtubule-based process • regulation of spindle organization • regulation of organelle organization • mitotic spindle organization • organelle organization • mitotic cell cycle process • microtubule-based process • cytoskeleton organization • regulation of microtubule cytoskeleton organization • protein localization • positive regulation of protein localization to cell periphery • regulation of localization • protein localization to cell periphery • cellular localization • regulation of protein localization • positive regulation of protein localization to cell cortex • regulation of protein localization to cell periphery • localization • regulation of cellular localization • regulation of protein localization to cell cortex • cellular macromolecule localization • macromolecule localization • positive regulation of protein localization • protein localization to cell cortex • response to ketone • response to prostaglandin • response to lipid • response to alcohol • response to prostaglandin E • cellular response to forskolin • cellular response to oxygen-containing compound • cellular response to chemical stimulus • cellular response to alcohol • response to forskolin • cellular response to lipid • cellular response to ketone • midbody • intracellular anatomical structure • nucleus • membrane-enclosed lumen • intracellular membraneless organelle • intracellular membrane-bounded organelle • nucleolus • intracellular organelle lumen • intracellular organelle • organelle lumen • membraneless organelle • nuclear lumen • cell cortex • cytoplasm • centrosome • microtubule organizing center • cytoskeleton • microtubule cytoskeleton • centriolar satellite • cytosol • nucleoplasm • vacuolar membrane • lytic vacuole • vacuole • lytic vacuole membrane • bounding membrane of organelle • lysosomal membrane • organelle membrane • lysosome • Golgi apparatus • endomembrane system • cilium • plasma membrane bounded cell projection • ciliary basal body • cell projection • molecular transducer activity • G protein-coupled receptor activity • transmembrane signaling receptor activity • signaling receptor activity • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cell surface receptor signaling pathway • developmental process • fat cell differentiation • cellular developmental process • cell differentiation • behavior • multicellular organismal process • system process • learning or memory • nervous system process • cognition • memory • nervous system development • cellular component biogenesis • multicellular organism development • cell junction organization • cellular component assembly • cell junction assembly • anatomical structure development • synapse organization • synapse assembly • system development • energy derivation by oxidation of organic compounds • energy reserve metabolic process • generation of precursor metabolites and energy • plasma membrane bounded cell projection organization • cell projection organization • cell development • neuron projection development • generation of neurons • neurogenesis • neuron differentiation • neuron development • cytoplasmic vesicle • intracellular vesicle • enzyme binding • GTPase binding • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • sensory perception of chemical stimulus • sensory perception • sensory perception of taste • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • camera-type eye development • sensory system development • cell population proliferation • cellular response to prostaglandin stimulus • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to hormone stimulus • small GTPase-mediated signal transduction • Ras protein signal transduction • intracellular signal transduction • intracellular signaling cassette • phospholipase C-activating G protein-coupled receptor signaling pathway • cellular response to nitrogen compound • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • cellular response to monoamine stimulus • synaptic signaling • cellular response to acetylcholine • cell-cell signaling • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • non-motile cilium • 9+0 non-motile cilium • neuron projection • photoreceptor disc membrane • photoreceptor outer segment • photoreceptor cell cilium
SCOP2	Domain Identifier	• Transducin (heterotrimeric G protein), gamma chain • Ras-like P-loop GTPases
SCOP2	Family Identifier	• Transducin (heterotrimeric G protein), gamma chain • Ras-like P-loop GTPases
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	Q5T601
Sequence	>7X2V_nogp_Chain_R T S F S I L M S P F V P S T I F P V V K W I T Y V G L G I S I G S L I L C L I I E A L F W K Q I K K S Q T S H T R R I C M V N I A L S L L I A D V W F I V G A T V D T T V N P S G V C T A A V F F T H F F Y L S L F F W M L M L G I L L A Y R I I L V F H H M A Q H L M M A V G F C L G Y G C P L I I S V I T I A V T Q P S N T Y K R K D V C W L N W S N G S K P L L A F V V P A L A I V A V N F V V V L L V L T K L W R P A T I I R V G K S L L I L T P L L G L T W G F G I G T I V D S Q N L A W H V I F A L L N A F Q G F F I L C F G I L L D S K L R Q L L F N K L S Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	8G2Y	B2	Adhesion	Adhesion	ADGRF1	Homo sapiens	-	LPC	chim(Gs-CtGq)/β1/γ2	3.44	2023-05-10	10.1038/s41467-023-38083-7
	8G2Y (No Gprot)	B2	Adhesion	Adhesion	ADGRF1	Homo sapiens	-	LPC		3.44	2023-05-10	10.1038/s41467-023-38083-7
	7WZ7	B2	Adhesion	Adhesion	ADGRF1	Homo sapiens	-	-	chim(NtGi1-G12)/β1/γ2	2.83	2022-09-28	10.1038/s41467-022-33173-4
	7WZ7 (No Gprot)	B2	Adhesion	Adhesion	ADGRF1	Homo sapiens	-	-		2.83	2022-09-28	10.1038/s41467-022-33173-4
	7WXU	B2	Adhesion	Adhesion	ADGRF1	Homo sapiens	-	-	chim(NtGi1-Gs-CtGq)/β1/γ2	2.85	2022-09-28	10.1038/s41467-022-33173-4
	7WXU (No Gprot)	B2	Adhesion	Adhesion	ADGRF1	Homo sapiens	-	-		2.85	2022-09-28	10.1038/s41467-022-33173-4
	7WXW	B2	Adhesion	Adhesion	ADGRF1	Homo sapiens	-	-	chim(NtGi1-Gs)/β1/γ2	2.84	2022-09-28	10.1038/s41467-022-33173-4
	7WXW (No Gprot)	B2	Adhesion	Adhesion	ADGRF1	Homo sapiens	-	-		2.84	2022-09-28	10.1038/s41467-022-33173-4
	7WY0	B2	Adhesion	Adhesion	ADGRF1	Homo sapiens	-	-	chim(NtGi1L-G13)/β1/γ2	2.83	2022-09-28	10.1038/s41467-022-33173-4
	7WY0 (No Gprot)	B2	Adhesion	Adhesion	ADGRF1	Homo sapiens	-	-		2.83	2022-09-28	10.1038/s41467-022-33173-4
	7X2V	B2	Adhesion	Adhesion	ADGRF1	Homo sapiens	-	-	Gi1/β1/γ2	3.09	2022-09-28	10.1038/s41467-022-33173-4
	7X2V (No Gprot)	B2	Adhesion	Adhesion	ADGRF1	Homo sapiens	-	-		3.09	2022-09-28	10.1038/s41467-022-33173-4
	7WU5	B2	Adhesion	Adhesion	ADGRF1	Homo sapiens	-	K6G	Gi1/β1/γ2	3	2022-04-27	10.1038/s41586-022-04580-w
	7WU5 (No Gprot)	B2	Adhesion	Adhesion	ADGRF1	Homo sapiens	-	K6G		3	2022-04-27	10.1038/s41586-022-04580-w
	7WU4	B2	Adhesion	Adhesion	ADGRF1	Homo sapiens	-	K6G	Gi1/β1/γ2	3.4	2022-04-27	10.1038/s41586-022-04580-w
	7WU4 (No Gprot)	B2	Adhesion	Adhesion	ADGRF1	Homo sapiens	-	K6G		3.4	2022-04-27	10.1038/s41586-022-04580-w
	7WU3	B2	Adhesion	Adhesion	ADGRF1	Homo sapiens	-	K6G	Gs/β1/γ2	3.1	2022-04-27	10.1038/s41586-022-04580-w
	7WU3 (No Gprot)	B2	Adhesion	Adhesion	ADGRF1	Homo sapiens	-	K6G		3.1	2022-04-27	10.1038/s41586-022-04580-w

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