Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg Int. Strength Num Of Links Community ConSurf
1G:G:V54 5.065406
2G:G:N59 6.754579
3G:G:F61 6.66167678
4A:A:V34 5.805485
5A:A:L36 3.835487
6A:A:K46 3.465409
7A:A:I49 5.85567
8A:A:I55 9.3875488
9A:A:I184 4.6325419
10A:A:E186 7.4575419
11A:A:F191 7.695685
12A:A:F196 7.665487
13A:A:F199 12.41415
14A:A:V201 4.1475419
15A:A:Q204 6.002519
16A:A:S206 5.62418
17A:A:W211 9.1325419
18A:A:F215 9.68419
19A:A:I222 4.7575407
20A:A:F223 6.5825439
21A:A:S228 3.7875409
22A:A:Y230 10.335118
23A:A:D231 10.0054119
24A:A:R242 9.635409
25A:A:H244 7.854254
26A:A:S246 4.1725439
27A:A:F250 9.6825439
28A:A:C254 3.95435
29A:A:W258 5.395405
30A:A:F259 7.86409
31A:A:L266 6.905439
32A:A:F267 7.29333669
33A:A:N269 5.7975469
34A:A:K270 5.755469
35A:A:F274 6.1756119
36A:A:Y287 5.845407
37A:A:Y296 12.9275404
38A:A:E298 5.9975404
39A:A:F307 5.40333638
40A:A:N311 4.52438
41A:A:K317 4.135437
42A:A:E318 3.3275434
43A:A:I319 5.806535
44A:A:Y320 2.85407
45A:A:H322 9.03469
46A:A:T324 5.7675469
47A:A:F336 6.2225488
48A:A:L353 4.6375407
49R:R:S568 3.635409
50R:R:F569 5.00667659
51R:R:L572 6.0325459
52R:R:P578 4.808336134
53R:R:F582 6.985401
54R:R:L593 5.805408
55R:R:I597 4.0775407
56R:R:F610 6.114278
57R:R:H621 6.515156
58R:R:D638 3.9425407
59R:R:V643 4.3125408
60R:R:H665 4.042509
61R:R:F666 7.61407
62R:R:Y668 5.04571758
63R:R:L671 5.88407
64R:R:W674 9.562867169
65R:R:L682 4.1625409
66R:R:R685 6.4854228
67R:R:P710 3.506509
68R:R:Y727 7.4275409
69R:R:L735 9.1175459
70R:R:F747 6.055458
71R:R:W770 5.994286
72R:R:T797 3.48409
73R:R:W804 9.29167659
74R:R:F806 4.922558
75R:R:H820 4.4745138
76R:R:F823 6.83559
77R:R:N827 10.7175459
78B:B:L4 3.0725404
79B:B:I18 4.115407
80B:B:L30 7.2975445
81B:B:T34 7.08445
82B:B:I37 5.9275442
83B:B:V40 3.675643
84B:B:M45 4.38754104
85B:B:H54 7.515409
86B:B:I58 5.7925409
87B:B:Y59 7.1385298
88B:B:W63 6.83333677
89B:B:L79 4.434507
90B:B:I81 5.64407
91B:B:W82 10.675219
92B:B:Y85 14.2375474
93B:B:N88 5.2525207
94B:B:K89 7.441676219
95B:B:H91 6.6625405
96B:B:I93 4.5775407
97B:B:L95 4.124308
98B:B:W99 6.81143719
99B:B:Y105 4.73833606
100B:B:N110 4.2825404
101B:B:Y111 6.5075404
102B:B:C114 3.05754308
103B:B:L117 5.098519
104B:B:I123 4.4825176
105B:B:Y124 4.755306
106B:B:H142 7.055129
107B:B:Y145 5.51333618
108B:B:F151 3.828509
109B:B:L152 4.92833623
110B:B:D163 7.06754129
111B:B:T165 5.45254127
112B:B:C166 4.116528
113B:B:L168 4.345426
114B:B:W169 10.5185128
115B:B:F180 7.9625427
116B:B:H183 8.30571729
117B:B:V187 3.8475429
118B:B:L190 5.9425425
119B:B:F199 8.82833629
120B:B:S201 3.778529
121B:B:W211 9.06857728
122B:B:E215 7.43254183
123B:B:H225 9.476676149
124B:B:D228 10.375419
125B:B:I232 5.8725408
126B:B:F234 4.30571795
127B:B:F235 7.4365196
128B:B:F241 8.02857796
129B:B:T243 5.485148
130B:B:D247 7.54754149
131B:B:T249 5.0845146
132B:B:R251 12.3875408
133B:B:D254 6.4525409
134B:B:L255 5.5475496
135B:B:M262 6.185444
136B:B:Y264 5.766505
137B:B:R283 9.25449
138B:B:L285 4.105406
139B:B:Y289 7.542507
140B:B:N295 7.84254326
141B:B:D298 8.4075449
142B:B:L300 3.3646
143B:B:V307 3.10254323
144B:B:H311 9.764109
145B:B:R314 16.72408
146B:B:V315 4.665407
147B:B:L318 4.74406
148B:B:V327 3.9575406
149B:B:T329 5.684108
150B:B:W332 15.3225249
151B:B:L336 4.5975407
152B:B:K337 5.214106
153B:B:W339 8.593336109
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
1B:B:I18 G:G:L19 10.14722.85YesNo079
2B:B:I18 G:G:E22 12.2674.1YesNo079
3B:B:T221 G:G:E22 12.72528.47NoNo079
4B:B:K209 B:B:T221 13.186616.52NoNo067
5B:B:K209 B:B:W211 13.622110.44NoYes268
6B:B:C148 B:B:L190 28.76984.76NoYes065
7B:B:F199 B:B:W211 19.021119.04YesYes298
8B:B:H62 B:B:Y105 68.68844.36NoYes066
9B:B:H62 B:B:R150 68.474910.16NoNo066
10B:B:L192 B:B:R150 56.0126.07NoNo056
11B:B:L152 B:B:L192 55.56794.15YesNo235
12B:B:L152 B:B:V158 40.33632.98YesNo235
13B:B:F199 B:B:V158 10.60957.87YesNo295
14B:B:L152 B:B:V213 10.83335.96YesNo234
15B:B:F199 B:B:V213 10.63662.62YesNo294
16B:B:I232 B:B:T243 21.23596.08YesYes088
17B:B:G244 B:B:T243 16.33883.64NoYes058
18B:B:G244 B:B:I273 16.10793.53NoNo056
19B:B:C250 B:B:I273 12.37556.55NoNo086
20B:B:F278 B:B:L285 10.29153.65NoYes076
21A:A:E28 R:R:Q618 83.3695.1NoNo047
22R:R:Q618 R:R:R685 83.60673.5NoYes2278
23A:A:N347 R:R:R685 85.79614.82NoYes088
24A:A:N347 R:R:V689 86.06541.48NoNo089
25A:A:I344 R:R:V689 21.43024.61NoNo069
26A:A:I344 A:A:T340 21.49243.04NoNo066
27A:A:F336 A:A:T340 21.5555.19YesNo086
28A:A:F191 A:A:F336 21.73117.5YesYes858
29A:A:F191 A:A:I55 21.97745.02YesYes858
30A:A:I55 A:A:V335 44.252912.29YesNo088
31A:A:F267 A:A:V335 66.77142.62YesNo098
32A:A:F267 A:A:H322 89.78037.92YesYes699
33A:A:F334 A:A:H322 89.895822.63NoYes039
34A:A:F334 A:A:Y320 89.91583.09NoYes037
35A:A:E318 A:A:Y320 89.9984.49YesYes047
36A:A:E318 A:A:N311 89.99232.63YesYes348
37A:A:K317 A:A:N311 89.78092.8YesYes378
38A:A:I264 A:A:K317 90.0272.91NoYes367
39A:A:I253 A:A:I264 1004.42NoNo086
40A:A:I253 A:A:L39 50.37972.85NoNo089
41A:A:L39 A:A:R208 50.34294.86NoNo099
42A:A:R208 A:A:W211 50.32533NoYes099
43A:A:Q204 A:A:W211 49.137317.52YesYes199
44A:A:Q204 B:B:L117 48.9263.99YesYes199
45B:B:L117 B:B:W99 49.45355.69YesYes199
46A:A:C214 B:B:W99 98.23732.61NoYes079
47A:A:C214 A:A:H213 98.1622.95NoNo078
48A:A:H213 A:A:W258 98.08666.35NoYes085
49A:A:E216 A:A:W258 78.56923.27NoYes075
50A:A:E216 B:B:K57 71.44679.45NoNo2479
51B:B:K57 B:B:Q75 71.93155.42NoNo099
52B:B:Q75 B:B:Y59 71.83994.51NoYes098
53B:B:A73 B:B:Y59 35.24846.67NoYes098
54B:B:A73 B:B:L79 35.14694.73NoYes097
55B:B:L79 B:B:V71 68.12652.98YesNo078
56B:B:V71 B:B:Y105 67.91817.57NoYes086
57R:R:F690 R:R:V689 64.90839.18NoNo089
58A:A:L194 R:R:F690 66.3048.53NoNo048
59A:A:L194 A:A:V34 66.50344.47NoYes045
60A:A:F196 A:A:V34 22.0937.87YesYes875
61A:A:F196 A:A:I55 22.152312.56YesYes878
62A:A:L36 A:A:V34 45.00824.47YesYes875
63A:A:I222 A:A:L36 45.27142.85YesYes077
64A:A:I222 A:A:V335 22.48414.61YesNo078
65A:A:I222 A:A:M53 23.30537.29YesNo078
66A:A:F267 A:A:M53 22.544.98YesNo698
67A:A:I221 A:A:I253 49.63962.94NoNo088
68A:A:F259 A:A:I221 49.620611.3YesNo098
69A:A:F259 A:A:I212 49.4435.02YesNo098
70A:A:I212 A:A:L37 49.42652.85NoNo089
71A:A:F215 A:A:L37 49.41138.53YesNo099
72A:A:F215 B:B:W99 49.186711.02YesYes199
73B:B:C103 B:B:Y59 35.24834.03NoYes2988
74B:B:C103 B:B:L79 35.16023.17NoYes087
75A:A:E28 A:A:R24 83.09910.47NoNo043
76A:A:R24 R:R:K615 80.93597.43NoNo038
77R:R:M627 R:R:R623 10.44548.69NoNo079
78R:R:I839 R:R:M627 11.60032.92NoNo077
79R:R:C603 R:R:I839 12.17723.27NoNo077
80R:R:A631 R:R:C603 12.46561.81NoNo087
81R:R:A631 R:R:L604 12.75394.73NoNo088
82R:R:L604 R:R:V628 13.33044.47NoNo087
83R:R:E607 R:R:V628 13.61854.28NoNo097
84R:R:E607 R:R:W611 13.89975.45NoNo099
85R:R:H621 R:R:W611 14.18564.23YesNo1569
86R:R:H621 R:R:Q695 80.394511.13YesNo066
87R:R:K615 R:R:Q695 80.66528.14NoNo086
88R:R:H621 R:R:I625 65.38347.95YesNo1567
89R:R:F703 R:R:I625 65.1172.51NoNo087
90R:R:F703 R:R:N629 64.84216.04NoNo089
91R:R:N629 R:R:Y707 60.0368.14NoNo1699
92R:R:S670 R:R:Y707 59.88222.54NoNo089
93R:R:S633 R:R:S670 50.44966.52NoNo088
94R:R:L671 R:R:S633 50.1713YesNo078
95R:R:L671 R:R:Y668 35.0763.52YesYes078
96R:R:F569 R:R:Y668 11.44724.13YesYes598
97R:R:W804 R:R:Y668 12.8932.89YesYes598
98R:R:F672 R:R:L671 13.40377.31NoYes097
99R:R:F672 R:R:W804 12.839519.04NoYes099
100R:R:F823 R:R:W804 11.47193.01YesYes599
101R:R:N827 R:R:W804 13.192713.56YesYes599
102B:B:S316 B:B:W332 13.64884.94NoYes099
103B:B:A104 B:B:R150 12.45042.77NoNo076
104B:B:A104 B:B:F151 12.21892.77NoYes079
105B:B:R314 B:B:T274 12.14623.88YesNo088
106B:B:T274 B:B:V315 12.01683.17NoYes087
107B:B:I232 B:B:S189 28.19659.29YesNo087
108B:B:C148 B:B:S189 28.48183.44NoNo067
109B:B:L190 B:B:V158 29.50874.47YesNo255
110A:A:W258 B:B:R314 19.37425YesYes058
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


PDB Summary
PDB 7X2V
Class B2
SubFamily Adhesion
Type Adhesion
SubType ADGRF1
Species Homo sapiens
Ligand -
Other Ligand(s) -
Protein Partners Gi1/Beta1/Gamma2
PDB Resolution 3.09
Date 2022-09-28
D.O.I. 10.1038/s41467-022-33173-4
Net Summary
Imin 2.61
Number of Linked Nodes 845
Number of Links 1004
Number of Hubs 153
Number of Links mediated by Hubs 562
Number of Communities 32
Number of Nodes involved in Communities 208
Number of Links involved in Communities 281
Path Summary
Number Of Nodes in MetaPath 111
Number Of Links MetaPath 110
Number of Shortest Paths 3084480
Length Of Smallest Path 3
Average Path Length 52.3888
Length of Longest Path 83
Minimum Path Strength 1.325
Average Path Strength 6.0251
Maximum Path Strength 29
Minimum Path Correlation 0.7
Average Path Correlation 0.98838
Maximum Path Correlation 1
Minimum % Of Corr. Nodes 1.72414
Average % Of Corr. Nodes 25.8441
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 41.1318
Maximum Path Hubs % 100
AnnotationTypeLinks
Gene OntologyMolecular Function
Gene OntologyBiological Process
Gene OntologyCellular Component
SCOP2Domain Identifier
SCOP2Family Identifier
Membrane Protein Annotations-• Orientations of Proteins in Membranes database (OPM)   • Protein Data Bank of Transmembrane Proteins (PDBTM)   • MemProtMD


Details about the values in these tables can be found in the corresponding documentation page .
PDBsumOpen PDBsum Page
ChainG
ProteinG Protein γ Sub unit
UniProtP59768
Sequence
>7X2V_Chain_G
NTASIAQAR KLVEQLKME ANIDRIKVS KAAADLMAY CEAHAKEDP 
LLTPVPASE NPFR


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainA
ProteinG Protein α Sub unit
UniProtP63096
Sequence
>7X2V_Chain_A
TLSAEDKAA VERSKMIDR NLREDGEKA AREVKLLLL GAGESGKST 
IVKQMKITG IVETHFTFK DLHFKMFDV GAQRSERKK WIHCFEGVT 
AIIFCVALS DYDLVLAMN RMHESMKLF DSICNNKWF TDTSIILFL 
NKKDLFEEK IKKSPLTIC YPEYAGSNT YEEAAAYIQ CQFEDLNKR 
KDTKEIYTH FTCSTDTKN VQFVFDAVT DVIIKNNLK DCGL


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainR
ProteinReceptor
UniProtQ5T601
Sequence
>7X2V_Chain_R
TSFSILMSP FVPSTIFPV VKWITYVGL GISIGSLIL CLIIEALFW 
KQIKKSQTS HTRRICMVN IALSLLIAD VWFIVGATV DTTVNPSGV 
CTAAVFFTH FFYLSLFFW MLMLGILLA YRIILVFHH MAQHLMMAV 
GFCLGYGCP LIISVITIA VTQPSNTYK RKDVCWLNW SNGSKPLLA 
FVVPALAIV AVNFVVVLL VLTKLWRPA TIIRVGKSL LILTPLLGL 
TWGFGIGTI VDSQNLAWH VIFALLNAF QGFFILCFG ILLDSKLRQ 
LLFNKLS


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainB
ProteinG Protein β Sub unit
UniProtP62873
Sequence
>7X2V_Chain_B
LDQLRQEAE QLKNQIRDA RKACADATL SQITNNIDP VGRIQMRTR 
RTLRGHLAK IYAMHWGTD SRLLVSASQ DGKLIIWDS YTTNKVHAI 
PLRSSWVMT CAYAPSGNY VACGGLDNI CSIYNLKTR EGNVRVSRE 
LAGHTGYLS CCRFLDDNQ IVTSSGDTT CALWDIETG QQTTTFTGH 
TGDVMSLSL APDTRLFVS GACDASAKL WDVREGMCR QTFTGHESD 
INAICFFPN GNAFATGSD DATCRLFDL RADQELMTY SHDNIICGI 
TSVSFSKSG RLLLAGYDD FNCNVWDAL KADRAGVLA GHDNRVSCL 
GVTDDGMAV ATGSWDSFL KIWN


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  




This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
7WU3B2AdhesionAdhesionADGRF1Homo sapiens-K6GGs/&β;1/&γ;23.12022-04-2710.1038/s41586-022-04580-w
7WU4B2AdhesionAdhesionADGRF1Homo sapiens-K6GGi1/&β;1/&γ;23.42022-04-2710.1038/s41586-022-04580-w
7WU5B2AdhesionAdhesionADGRF1Homo sapiens-K6GGi1/&β;1/&γ;232022-04-2710.1038/s41586-022-04580-w
7WXUB2AdhesionAdhesionADGRF1Homo sapiens--chim(NtGi1-Gs-CtGq)/&β;1/&γ;22.852022-09-2810.1038/s41467-022-33173-4
7WXWB2AdhesionAdhesionADGRF1Homo sapiens--chim(NtGi1-Gs)/&β;1/&γ;22.842022-09-2810.1038/s41467-022-33173-4
7WY0B2AdhesionAdhesionADGRF1Homo sapiens--chim(NtGi1L-G13)/&β;1/&γ;22.832022-09-2810.1038/s41467-022-33173-4
7WZ7B2AdhesionAdhesionADGRF1Homo sapiens--chim(NtGi1-G12)/&β;1/&γ;22.832022-09-2810.1038/s41467-022-33173-4
7X2VB2AdhesionAdhesionADGRF1Homo sapiens--Gi1/&β;1/&γ;23.092022-09-2810.1038/s41467-022-33173-4
8G2YB2AdhesionAdhesionADGRF1Homo sapiens-LPCchim(Gs-CtGq)/&β;1/&γ;23.442023-05-1010.1038/s41467-023-38083-7




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Download 7X2V.zip



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