Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg Int. Strength Num Of Links Community ConSurf
1R:R:F569 3.798519
2R:R:S574 4.0625409
3R:R:V577 3.94413
4R:R:P578 3.466514
5R:R:L593 2.575618
6R:R:I597 3.03407
7R:R:L600 2.9825409
8R:R:R624 4.646559
9R:R:L634 3.4125409
10R:R:D638 3.18507
11R:R:W640 6.545406
12R:R:C657 3.8825439
13R:R:F662 5.615478
14R:R:F666 5.25407
15R:R:Y668 4.296508
16R:R:L669 3.07509
17R:R:F672 5.1409
18R:R:W674 6.08571729
19R:R:Y684 5.54488
20R:R:C709 2.325408
21R:R:P710 2.95509
22R:R:Y727 5.1275479
23R:R:C733 3.525439
24R:R:W734 7.5325448
25R:R:P743 1.97667608
26R:R:V762 1.49408
27R:R:V789 2.6925408
28R:R:H820 4.925418
29R:R:F823 5.51419
30R:R:N827 6.865409
31R:R:Q830 3.1275409
32R:R:L835 4.475408
33R:R:F837 5.21408
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
1R:R:F569 R:R:L572 13.26764.87YesNo099
2R:R:F641 R:R:L572 12.05223.65NoNo099
3R:R:F641 R:R:I571 10.97065.02NoNo097
4R:R:S568 R:R:V577 10.9883.23NoYes093
5R:R:F569 R:R:F823 26.9223.22YesYes199
6R:R:F823 R:R:G807 22.20873.01YesNo199
7R:R:G807 R:R:T810 21.19393.64NoNo197
8R:R:H820 R:R:T810 18.05362.74YesNo187
9R:R:F569 R:R:L593 12.77043.65YesYes198
10R:R:F569 R:R:Y668 41.98362.06YesYes098
11R:R:A828 R:R:G592 10.3921.95NoNo089
12R:R:A828 R:R:L593 12.45351.58NoYes088
13R:R:D638 R:R:L593 12.68322.71YesYes078
14R:R:D638 R:R:Y668 51.34923.45YesYes078
15R:R:C603 R:R:L835 10.18846.35NoYes078
16R:R:C603 R:R:L600 13.40141.59NoYes079
17R:R:L600 R:R:L634 21.83654.15YesYes099
18R:R:D638 R:R:L634 43.08274.07YesYes079
19R:R:L634 R:R:Q830 15.37862.66YesYes099
20R:R:F823 R:R:N827 10.208812.08YesYes099
21R:R:G831 R:R:L600 14.78833.42NoYes099
22R:R:G831 R:R:Q830 12.89831.64NoYes099
23R:R:L845 R:R:R624 19.88547.29NoYes089
24R:R:E607 R:R:R624 25.37516.98NoYes099
25R:R:E607 R:R:V628 26.63995.7NoNo097
26R:R:N629 R:R:V628 28.02111.48NoNo097
27R:R:N629 R:R:W674 29.271322.6NoYes299
28R:R:M677 R:R:W674 97.96763.49NoYes069
29R:R:L705 R:R:M677 98.97944.24NoNo066
30R:R:C709 R:R:L705 1001.59YesNo086
31R:R:C709 R:R:F673 27.18074.19YesNo088
32R:R:F673 R:R:L669 27.38142.44NoYes089
33R:R:H665 R:R:L669 81.98135.14NoYes099
34R:R:F747 R:R:H665 81.6442.26NoNo089
35R:R:F747 R:R:Y668 81.33584.13NoYes088
36R:R:C709 R:R:P710 47.14181.88YesYes089
37R:R:L669 R:R:P710 29.37023.28YesYes099
38R:R:C709 R:R:I713 27.18071.64YesNo089
39R:R:I713 R:R:L669 27.38142.85NoYes099
40R:R:K844 R:R:S843 10.15931.53NoNo085
41R:R:D842 R:R:S843 11.60741.47NoNo095
42R:R:D842 R:R:L845 13.04954.07NoNo098
43R:R:M698 R:R:T622 10.12154.52NoNo087
44R:R:C626 R:R:T622 25.43031.69NoNo077
45R:R:C626 R:R:W674 67.07082.61NoYes079
46R:R:L681 R:R:R685 13.01174.86NoNo078
47R:R:L681 R:R:T622 14.30572.95NoNo077
48R:R:C626 R:R:L678 43.64683.17NoNo078
49R:R:G831 R:R:I834 23.56651.76NoNo099
50R:R:F666 R:R:S714 13.88995.28YesNo079
51R:R:F662 R:R:S714 13.78233.96YesNo089
52R:R:F662 R:R:Y727 10.65653.09YesYes789
53R:R:G679 R:R:L678 11.29331.71NoNo098
54R:R:L678 R:R:L800 31.87084.15NoNo089
55R:R:R685 R:R:Y684 10.12745.14NoYes088
56R:R:P772 R:R:T785 10.25531.75NoNo077
57R:R:T785 R:R:W770 13.17756.06NoNo076
58R:R:V789 R:R:W770 14.62551.23YesNo086
59R:R:L766 R:R:V789 17.23374.47NoYes078
60R:R:L766 R:R:V762 18.65551.49NoYes078
61R:R:L800 R:R:V762 29.55051.49NoYes098
62R:R:F833 R:R:P798 11.70332.89NoNo079
63R:R:I834 R:R:P798 16.4661.69NoNo099
64R:R:H820 R:R:P578 10.63913.05YesYes184
65R:R:T664 R:R:Y668 13.15422.5NoYes078
66R:R:F666 R:R:P710 21.50215.78YesYes079
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


PDB Summary
PDB 7WXW_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.
Net Summary
Imin 1.64
Number of Linked Nodes 251
Number of Links 280
Number of Hubs 33
Number of Links mediated by Hubs 127
Number of Communities 9
Number of Nodes involved in Communities 40
Number of Links involved in Communities 46
Path Summary
Number Of Nodes in MetaPath 67
Number Of Links MetaPath 66
Number of Shortest Paths 54433
Length Of Smallest Path 3
Average Path Length 16.041
Length of Longest Path 33
Minimum Path Strength 1.22
Average Path Strength 3.8441
Maximum Path Strength 13.41
Minimum Path Correlation 0.7
Average Path Correlation 0.931575
Maximum Path Correlation 0.99
Minimum % Of Corr. Nodes 3.7037
Average % Of Corr. Nodes 49.4503
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 38.922
Maximum Path Hubs % 100
AnnotationTypeLinks
Gene OntologyMolecular Function
Gene OntologyBiological Process• cellular response to stimulus   • regulation of biological process   • regulation of cellular process   • response to stimulus   • signaling   • biological regulation   • adenylate cyclase-activating G protein-coupled receptor signaling pathway   • cell communication   • adenylate cyclase-modulating G protein-coupled receptor signaling pathway   • G protein-coupled receptor signaling pathway   • cellular process   • signal transduction   • cell surface receptor signaling pathway   • regulation of lipid metabolic process   • primary metabolic process   • metabolic process   • regulation of metabolic process   • lipid metabolic process   • regulation of primary metabolic process   • developmental process   • fat cell differentiation   • cellular developmental process   • cell differentiation   • behavior   • multicellular organismal process   • system process   • learning or memory   • nervous system process   • cognition   • memory   • nervous system development   • cellular component organization   • cellular component biogenesis   • multicellular organism development   • cell junction organization   • cellular component assembly   • cell junction assembly   • anatomical structure development   • synapse organization   • cellular component organization or biogenesis   • synapse assembly   • system development   • energy derivation by oxidation of organic compounds   • energy reserve metabolic process   • generation of precursor metabolites and energy   • plasma membrane bounded cell projection organization   • cell projection organization   • cell development   • neuron projection development   • generation of neurons   • neurogenesis   • neuron differentiation   • neuron development   • membrane-bounded organelle   • intracellular organelle   • cellular anatomical structure   • intracellular anatomical structure   • cytoplasmic vesicle   • organelle   • intracellular vesicle   • cytoplasm   • intracellular membrane-bounded organelle   • vesicle   • membrane   • extracellular region   • cell periphery   • plasma membrane   • protein binding   • binding   • G-protein beta-subunit binding   • fibroblast proliferation   • cell population proliferation   • cellular response to nitrogen compound   • response to dopamine   • cellular response to dopamine   • response to monoamine   • response to catecholamine   • adenylate cyclase-activating dopamine receptor signaling pathway   • cellular response to catecholamine stimulus   • G protein-coupled dopamine receptor signaling pathway   • response to oxygen-containing compound   • response to nitrogen compound   • cellular response to oxygen-containing compound   • cellular response to chemical stimulus   • cellular response to monoamine stimulus   • response to chemical   • response to ketone   • response to prostaglandin   • response to lipid   • response to endogenous stimulus   • response to alcohol   • cellular response to prostaglandin stimulus   • cellular response to endogenous stimulus   • cellular response to prostaglandin E stimulus   • cellular response to alcohol   • response to hormone   • cellular response to lipid   • response to prostaglandin E   • cellular response to ketone   • cellular response to hormone stimulus   • protein-containing complex   • extrinsic component of plasma membrane   • catalytic complex   • plasma membrane protein complex   • cytoplasmic side of membrane   • membrane protein complex   • heterotrimeric G-protein complex   • side of membrane   • cytoplasmic side of plasma membrane   • GTPase complex   • extrinsic component of membrane   • extrinsic component of cytoplasmic side of plasma membrane   • extracellular exosome   • extracellular vesicle   • extracellular organelle   • extracellular space   • extracellular membrane-bounded organelle   • synapse   • cell junction   • enzyme binding   • GTPase binding   • protein-containing complex binding   • pyrophosphatase activity   • GTPase activity   • ribonucleoside triphosphate phosphatase activity   • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides   • hydrolase activity   • hydrolase activity, acting on acid anhydrides   • catalytic activity   • signaling receptor complex adaptor activity   • protein-macromolecule adaptor activity   • molecular adaptor activity   • signaling adaptor activity   • sensory perception of chemical stimulus   • sensory perception   • sensory perception of taste   • sensory organ development   • eye development   • animal organ development   • retina development in camera-type eye   • visual system development   • camera-type eye development   • sensory system development   • small GTPase-mediated signal transduction   • Ras protein signal transduction   • intracellular signal transduction   • intracellular signaling cassette   • phospholipase C-activating G protein-coupled receptor signaling pathway   • synaptic signaling   • cellular response to acetylcholine   • cell-cell signaling   • acetylcholine receptor signaling pathway   • postsynaptic signal transduction   • G protein-coupled acetylcholine receptor signaling pathway   • response to acetylcholine   • non-motile cilium   • 9+0 non-motile cilium   • cilium   • neuron projection   • photoreceptor disc membrane   • photoreceptor outer segment   • plasma membrane bounded cell projection   • cell projection   • photoreceptor cell cilium   • organelle membrane   • cytosol   • vacuolar membrane   • lytic vacuole   • vacuole   • lytic vacuole membrane   • bounding membrane of organelle   • lysosomal membrane   • lysosome
Gene OntologyCellular Component
SCOP2Domain Identifier• Transducin (heterotrimeric G protein), gamma chain
SCOP2Family Identifier• Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations-• Orientations of Proteins in Membranes database (OPM)   • Protein Data Bank of Transmembrane Proteins (PDBTM)   • MemProtMD


Details about the values in these tables can be found in the corresponding documentation page .
PDBsumOpen PDBsum Page
ChainR
ProteinReceptor
UniProtQ5T601
Sequence
>7WXW_nogp_Chain_R
TSFSILMSP FVPSTIFPV VKWITYVGL GISIGSLIL CLIIEALFW 
KQIKKSQTS HTRRICMVN IALSLLIAD VWFIVGATV DTTVNPSGV 
CTAAVFFTH FFYLSLFFW MLMLGILLA YRIILVFHH MAQHLMMAV 
GFCLGYGCP LIISVITIA VTQPSNTYK RKDVCWLNW SNGSKPLLA 
FVVPALAIV AVNFVVVLL VLTKLWRPA TIIRVGKSL LILTPLLGL 
TWGFGIGTI VDSQNLAWH VIFALLNAF QGFFILCFG ILLDSKLRQ 
LLFNKLS


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  




This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
8G2YB2AdhesionAdhesionADGRF1Homo sapiens-LPCchim(Gs-CtGq)/β1/γ23.442023-05-1010.1038/s41467-023-38083-7
8G2Y (No Gprot) B2AdhesionAdhesionADGRF1Homo sapiens-LPC3.442023-05-1010.1038/s41467-023-38083-7
7WZ7B2AdhesionAdhesionADGRF1Homo sapiens--chim(NtGi1-G12)/β1/γ22.832022-09-2810.1038/s41467-022-33173-4
7WZ7 (No Gprot) B2AdhesionAdhesionADGRF1Homo sapiens--2.832022-09-2810.1038/s41467-022-33173-4
7WXUB2AdhesionAdhesionADGRF1Homo sapiens--chim(NtGi1-Gs-CtGq)/β1/γ22.852022-09-2810.1038/s41467-022-33173-4
7WXU (No Gprot) B2AdhesionAdhesionADGRF1Homo sapiens--2.852022-09-2810.1038/s41467-022-33173-4
7WXWB2AdhesionAdhesionADGRF1Homo sapiens--chim(NtGi1-Gs)/β1/γ22.842022-09-2810.1038/s41467-022-33173-4
7WXW (No Gprot) B2AdhesionAdhesionADGRF1Homo sapiens--2.842022-09-2810.1038/s41467-022-33173-4
7WY0B2AdhesionAdhesionADGRF1Homo sapiens--chim(NtGi1L-G13)/β1/γ22.832022-09-2810.1038/s41467-022-33173-4
7WY0 (No Gprot) B2AdhesionAdhesionADGRF1Homo sapiens--2.832022-09-2810.1038/s41467-022-33173-4
7X2VB2AdhesionAdhesionADGRF1Homo sapiens--Gi1/β1/γ23.092022-09-2810.1038/s41467-022-33173-4
7X2V (No Gprot) B2AdhesionAdhesionADGRF1Homo sapiens--3.092022-09-2810.1038/s41467-022-33173-4
7WU5B2AdhesionAdhesionADGRF1Homo sapiens-K6GGi1/β1/γ232022-04-2710.1038/s41586-022-04580-w
7WU5 (No Gprot) B2AdhesionAdhesionADGRF1Homo sapiens-K6G32022-04-2710.1038/s41586-022-04580-w
7WU4B2AdhesionAdhesionADGRF1Homo sapiens-K6GGi1/β1/γ23.42022-04-2710.1038/s41586-022-04580-w
7WU4 (No Gprot) B2AdhesionAdhesionADGRF1Homo sapiens-K6G3.42022-04-2710.1038/s41586-022-04580-w
7WU3B2AdhesionAdhesionADGRF1Homo sapiens-K6GGs/β1/γ23.12022-04-2710.1038/s41586-022-04580-w
7WU3 (No Gprot) B2AdhesionAdhesionADGRF1Homo sapiens-K6G3.12022-04-2710.1038/s41586-022-04580-w




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Download 7WXW_nogp.zip



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