psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:S568	R:R:S570	4.89	No	Yes	0	9	9
2	R:R:F569	R:R:L572	6.09	Yes	Yes	2	9	9
3	R:R:F569	R:R:T589	6.49	Yes	No	0	9	9
4	R:R:F569	R:R:L593	3.65	Yes	No	0	9	8
5	R:R:F569	R:R:F641	5.36	Yes	No	2	9	9
6	R:R:S570	R:R:S574	4.89	Yes	Yes	3	9	9
7	R:R:S570	R:R:V577	4.85	Yes	No	0	9	3
8	R:R:H820	R:R:S570	5.58	Yes	Yes	3	8	9
9	R:R:I571	R:R:V732	6.14	No	No	0	7	4
10	R:R:I571	R:R:W734	3.52	No	Yes	0	7	8
11	R:R:F641	R:R:L572	3.65	No	Yes	2	9	9
12	R:R:L572	R:R:Y668	7.03	Yes	Yes	2	9	8
13	R:R:F747	R:R:L572	3.65	Yes	Yes	2	8	9
14	R:R:M573	R:R:V748	7.61	No	No	0	9	7
15	R:R:G807	R:R:M573	5.24	No	No	0	9	9
16	R:R:F823	R:R:M573	7.46	No	No	0	9	9
17	R:R:P575	R:R:S574	3.56	Yes	Yes	3	6	9
18	R:R:S574	R:R:S814	3.26	Yes	No	3	9	5
19	R:R:H820	R:R:S574	4.18	Yes	Yes	3	8	9
20	R:R:P575	R:R:W737	20.27	Yes	No	0	6	6
21	R:R:I811	R:R:P575	3.39	No	Yes	0	5	6
22	R:R:P575	R:R:S814	3.56	Yes	No	3	6	5
23	R:R:P578	R:R:V577	3.53	Yes	No	0	4	3
24	R:R:I581	R:R:P578	6.77	Yes	Yes	0	4	4
25	R:R:H820	R:R:P578	4.58	Yes	Yes	0	8	4
26	R:R:I581	R:R:V585	6.14	Yes	No	0	4	8
27	R:R:F582	R:R:P583	4.33	No	No	0	1	1
28	R:R:F582	R:R:K586	6.2	No	No	0	1	3
29	R:R:K586	R:R:W587	3.48	No	No	0	3	4
30	R:R:F829	R:R:G592	4.52	No	No	0	7	9
31	R:R:D638	R:R:L593	5.43	Yes	No	0	7	8
32	R:R:F829	R:R:I595	5.02	No	No	0	7	7
33	R:R:D638	R:R:S596	4.42	Yes	No	0	7	9
34	R:R:G831	R:R:S596	3.71	No	No	0	9	9
35	R:R:I597	R:R:L635	4.28	No	No	0	7	8
36	R:R:L600	R:R:L634	4.15	No	No	0	9	9
37	R:R:L600	R:R:L635	8.3	No	No	0	9	8
38	R:R:I601	R:R:L635	4.28	No	No	0	5	8
39	R:R:L602	R:R:L835	4.15	No	No	0	6	8
40	R:R:I606	R:R:L849	5.71	No	No	0	8	7
41	R:R:E607	R:R:W611	6.54	No	No	0	9	9
42	R:R:E607	R:R:R624	9.3	No	Yes	0	9	9
43	R:R:F610	R:R:L848	8.53	Yes	No	0	8	7
44	R:R:F610	R:R:K852	3.72	Yes	No	0	8	4
45	R:R:K615	R:R:W611	4.64	Yes	No	0	8	9
46	R:R:K612	R:R:K615	5.75	Yes	Yes	5	7	8
47	R:R:K612	R:R:K616	10.06	Yes	No	0	7	7
48	R:R:H621	R:R:K612	6.55	No	Yes	5	6	7
49	R:R:I614	R:R:K844	4.36	No	No	0	7	8
50	R:R:H621	R:R:K615	22.27	No	Yes	5	6	8
51	R:R:K615	R:R:R624	9.9	Yes	Yes	0	8	9
52	R:R:S617	R:R:T619	4.8	No	No	0	8	8
53	R:R:S617	R:R:S620	3.26	No	No	0	8	8
54	R:R:Q618	R:R:R685	5.84	No	Yes	0	7	8
55	R:R:H692	R:R:Q618	6.18	No	No	0	6	7
56	R:R:Q618	R:R:Q695	7.68	No	No	0	7	6
57	R:R:R685	R:R:T619	12.94	Yes	No	0	8	8
58	R:R:R624	R:R:S620	3.95	Yes	No	0	9	8
59	R:R:L681	R:R:T622	7.37	No	No	0	7	7
60	R:R:T622	W:W:?1	4.85	No	Yes	0	7	0
61	R:R:R623	R:R:R624	7.46	No	Yes	0	9	9
62	R:R:M627	R:R:R623	7.44	No	No	0	7	9
63	R:R:I625	R:R:M699	4.37	No	No	0	7	7
64	R:R:I625	W:W:?1	4.7	No	Yes	0	7	0
65	R:R:C626	W:W:?1	3.92	No	Yes	0	7	0
66	R:R:L799	R:R:M627	8.48	No	No	0	6	7
67	R:R:N629	R:R:W674	25.99	No	Yes	1	9	9
68	R:R:F703	R:R:N629	8.46	No	No	1	8	9
69	R:R:N629	R:R:Y707	4.65	No	No	1	9	9
70	R:R:S633	R:R:S670	4.89	No	No	0	8	8
71	R:R:D638	R:R:L634	8.14	Yes	No	0	7	9
72	R:R:L634	R:R:L671	4.15	No	No	0	9	7
73	R:R:F667	R:R:I636	8.79	No	No	0	8	7
74	R:R:A637	R:R:F667	4.16	No	No	0	9	8
75	R:R:A637	R:R:Y668	4	No	Yes	0	9	8
76	R:R:D638	R:R:Y668	4.6	Yes	Yes	0	7	8
77	R:R:F663	R:R:W640	16.04	No	No	0	8	6
78	R:R:V647	R:R:V656	9.62	No	No	0	5	5
79	R:R:C657	R:R:T649	5.07	No	Yes	4	9	3
80	R:R:K728	R:R:T649	4.5	Yes	Yes	4	5	3
81	R:R:C733	R:R:T649	3.38	No	Yes	4	9	3
82	R:R:N652	R:R:V651	5.91	No	No	0	4	1
83	R:R:N652	R:R:V656	4.43	No	No	0	4	5
84	R:R:S654	R:R:T658	6.4	No	No	0	4	6
85	R:R:C657	R:R:K728	8.08	No	Yes	4	9	5
86	R:R:C657	R:R:C733	7.28	No	No	4	9	9
87	R:R:V661	R:R:Y727	6.31	No	Yes	0	8	9
88	R:R:F662	R:R:F663	5.36	No	No	0	8	8
89	R:R:F662	R:R:S714	3.96	No	No	0	8	9
90	R:R:T664	R:R:Y668	3.75	No	Yes	0	7	8
91	R:R:T664	R:R:W734	4.85	No	Yes	0	7	8
92	R:R:H665	R:R:L669	9	Yes	Yes	0	9	9
93	R:R:H665	R:R:S714	4.18	Yes	No	0	9	9
94	R:R:H665	R:R:T717	5.48	Yes	No	0	9	9
95	R:R:H665	R:R:L735	3.86	Yes	Yes	0	9	9
96	R:R:F747	R:R:H665	6.79	Yes	Yes	0	8	9
97	R:R:F666	R:R:F667	5.36	No	No	0	7	8
98	R:R:F666	R:R:L711	4.87	No	No	0	7	7
99	R:R:F666	R:R:S714	9.25	No	No	0	7	9
100	R:R:F747	R:R:Y668	4.13	Yes	Yes	2	8	8
101	R:R:L669	R:R:P710	3.28	Yes	No	0	9	9
102	R:R:L669	R:R:P750	3.28	Yes	No	0	9	9
103	R:R:S670	R:R:Y707	3.82	No	No	0	8	9
104	R:R:P710	R:R:S670	3.56	No	No	0	9	8
105	R:R:L671	R:R:M675	4.24	No	Yes	0	7	9
106	R:R:F672	R:R:M675	3.73	Yes	Yes	0	9	9
107	R:R:F672	R:R:F747	7.5	Yes	Yes	0	9	8
108	R:R:A751	R:R:F672	5.55	No	Yes	0	9	9
109	R:R:F672	R:R:W804	16.04	Yes	Yes	0	9	9
110	R:R:F673	R:R:L705	6.09	No	No	0	8	6
111	R:R:C709	R:R:F673	4.19	No	No	0	8	8
112	R:R:F673	R:R:P710	11.56	No	No	0	8	9
113	R:R:M677	R:R:W674	4.65	Yes	Yes	1	6	9
114	R:R:F703	R:R:W674	8.02	No	Yes	1	8	9
115	R:R:G706	R:R:W674	4.22	No	Yes	0	9	9
116	R:R:W674	R:R:Y707	7.72	Yes	No	1	9	9
117	R:R:W674	W:W:?1	3.75	Yes	Yes	1	9	0
118	R:R:G801	R:R:M675	3.49	No	Yes	0	9	9
119	R:R:L676	R:R:M677	4.24	Yes	Yes	0	7	6
120	R:R:I680	R:R:L676	4.28	No	Yes	0	8	7
121	R:R:I754	R:R:L676	7.14	No	Yes	0	9	7
122	R:R:G702	R:R:M677	3.49	No	Yes	1	7	6
123	R:R:L705	R:R:M677	5.65	No	Yes	0	6	6
124	R:R:M677	W:W:?1	8.14	Yes	Yes	1	6	0
125	R:R:I680	W:W:?1	5.87	No	Yes	0	8	0
126	R:R:L681	R:R:R685	4.86	No	Yes	0	7	8
127	R:R:A683	R:R:V761	3.39	No	No	0	6	8
128	R:R:R685	R:R:Y684	10.29	Yes	Yes	1	8	8
129	R:R:L688	R:R:Y684	7.03	No	Yes	1	6	8
130	R:R:H691	R:R:Y684	6.53	Yes	Yes	1	7	8
131	R:R:M693	R:R:Y684	7.18	No	Yes	1	5	8
132	R:R:M698	R:R:Y684	3.59	No	Yes	1	8	8
133	R:R:M698	R:R:R685	4.96	No	Yes	1	8	8
134	R:R:I686	R:R:L764	5.71	No	No	0	7	7
135	R:R:I686	R:R:K768	7.27	No	No	0	7	8
136	R:R:I687	R:R:L764	4.28	No	No	0	6	7
137	R:R:I687	W:W:?1	9.39	No	Yes	0	6	0
138	R:R:H691	R:R:L688	6.43	Yes	No	1	7	6
139	R:R:L688	W:W:?1	9.11	No	Yes	1	6	0
140	R:R:F690	R:R:V689	9.18	No	No	0	8	9
141	R:R:H691	R:R:M693	9.19	Yes	No	1	7	5
142	R:R:H691	W:W:?1	5.29	Yes	Yes	1	7	0
143	R:R:M693	W:W:?1	3.49	No	Yes	1	5	0
144	R:R:H696	R:R:Q695	7.42	No	No	0	5	6
145	R:R:F703	R:R:M699	6.22	No	No	0	8	7
146	R:R:G702	W:W:?1	5.63	No	Yes	1	7	0
147	R:R:T717	R:R:Y727	4.99	No	Yes	0	9	9
148	R:R:I718	R:R:Q722	6.86	No	No	2	7	7
149	R:R:I718	R:R:Y727	8.46	No	Yes	2	7	9
150	R:R:T721	R:R:Y727	3.75	Yes	Yes	0	9	9
151	R:R:P743	R:R:T721	12.24	No	Yes	0	8	9
152	R:R:Q722	R:R:Y727	5.64	No	Yes	2	7	9
153	R:R:S724	R:R:T726	4.8	No	Yes	0	3	4
154	R:R:N736	R:R:T726	4.39	No	Yes	0	8	4
155	R:R:L735	R:R:Y727	5.86	Yes	Yes	2	9	9
156	R:R:R729	R:R:V732	6.54	No	No	0	5	4
157	R:R:R729	R:R:W734	5	No	Yes	0	5	8
158	R:R:L735	R:R:W734	9.11	Yes	Yes	2	9	8
159	R:R:L744	R:R:W734	4.56	Yes	Yes	2	8	8
160	R:R:F747	R:R:W734	5.01	Yes	Yes	2	8	8
161	R:R:L735	R:R:P743	3.28	Yes	No	0	9	8
162	R:R:L735	R:R:L744	4.15	Yes	Yes	2	9	8
163	R:R:K742	R:R:W737	6.96	No	No	0	7	6
164	R:R:L744	R:R:W737	6.83	Yes	No	0	8	6
165	R:R:K742	R:R:L745	4.23	No	No	0	7	8
166	R:R:L744	R:R:V748	4.47	Yes	No	0	8	7
167	R:R:I811	R:R:V748	4.61	No	No	0	5	7
168	R:R:P750	R:R:V749	3.53	No	No	0	9	7
169	R:R:I808	R:R:L752	4.28	No	No	0	7	8
170	R:R:I754	R:R:N758	4.25	No	No	0	9	9
171	R:R:L800	R:R:N758	10.98	No	No	0	9	9
172	R:R:F759	R:R:L763	6.09	No	No	0	4	4
173	R:R:L796	R:R:V762	4.47	No	No	0	9	8
174	R:R:L802	R:R:V762	4.47	No	No	0	7	8
175	R:R:L766	R:R:V789	4.47	No	Yes	0	7	8
176	R:R:L766	R:R:L793	5.54	No	No	0	7	7
177	R:R:R771	R:R:T767	3.88	No	No	0	8	4
178	R:R:T785	R:R:W770	3.64	No	No	0	7	6
179	R:R:V789	R:R:W770	3.68	Yes	No	0	8	6
180	R:R:P772	R:R:R771	5.76	No	No	0	7	8
181	R:R:R777	R:R:T773	10.35	No	No	0	5	6
182	R:R:R777	R:R:V774	6.54	No	No	0	5	5
183	R:R:E776	R:R:G775	3.27	No	No	0	5	6
184	R:R:R777	R:R:R780	8.53	No	No	0	5	3
185	R:R:D782	R:R:S779	4.42	No	No	0	7	4
186	R:R:I787	R:R:R788	5.01	No	No	0	4	7
187	R:R:K791	R:R:R788	7.43	No	No	0	8	7
188	R:R:F837	R:R:L794	9.74	No	No	0	8	6
189	R:R:L794	R:R:L841	4.15	No	No	0	6	5
190	R:R:G838	R:R:I795	3.53	No	No	0	8	7
191	R:R:L796	R:R:L800	6.92	No	No	0	9	9
192	R:R:P798	R:R:T797	3.5	No	No	0	9	9
193	R:R:L802	R:R:T797	8.84	No	No	0	7	9
194	R:R:T803	R:R:W804	3.64	No	Yes	7	9	9
195	R:R:N827	R:R:T803	10.24	No	No	7	9	9
196	R:R:N827	R:R:W804	18.08	No	Yes	7	9	9
197	R:R:Q830	R:R:W804	7.67	No	Yes	0	9	9
198	R:R:F806	R:R:I822	3.77	No	No	0	8	5
199	R:R:F806	R:R:F823	4.29	No	No	0	8	9
200	R:R:F806	R:R:L826	3.65	No	No	0	8	6
201	R:R:H820	R:R:T810	6.85	Yes	No	0	8	7
202	R:R:D813	R:R:Q815	6.53	No	No	0	4	3
203	R:R:D813	R:R:N816	10.77	No	No	0	4	5
204	R:R:N816	R:R:W819	14.69	No	No	0	5	6
205	R:R:F823	R:R:N827	10.87	No	No	0	9	9
206	R:R:L825	R:R:L826	5.54	No	No	0	5	6
207	R:R:F832	R:R:F833	6.43	No	No	0	5	7
208	R:R:C836	R:R:F832	6.98	No	No	0	7	5
209	R:R:C836	R:R:F837	5.59	No	No	0	7	8
210	R:R:F850	R:R:L840	6.09	No	No	0	3	7
211	R:R:D842	R:R:K844	6.91	No	No	6	9	8
212	R:R:D842	R:R:L845	4.07	No	No	6	9	8
213	R:R:R846	R:R:S843	6.59	No	No	0	7	5
214	R:R:K844	R:R:L845	7.05	No	No	6	8	8
215	R:R:F850	R:R:R846	5.34	No	No	0	3	7
216	R:R:K852	R:R:N851	4.2	No	No	0	4	4
217	R:R:F829	R:R:F832	3.22	No	No	0	7	5
218	R:R:S741	R:R:T721	3.2	No	Yes	0	8	9
219	R:R:S738	R:R:T726	3.2	No	Yes	0	2	4
220	R:R:S741	R:R:T726	3.2	No	Yes	0	8	4
221	R:R:C603	R:R:L835	3.17	No	No	0	7	8
222	R:R:C626	R:R:L678	3.17	No	No	0	7	8
223	R:R:P723	R:R:Q722	3.16	No	No	0	8	7
224	R:R:A631	R:R:L604	3.15	No	No	0	8	8
225	R:R:I581	R:R:V584	3.07	Yes	No	0	4	3
226	R:R:I588	R:R:V585	3.07	No	No	0	9	8
227	R:R:K728	R:R:V661	3.04	Yes	No	0	5	8
228	R:R:L835	R:R:S599	3	No	No	0	8	8
229	R:R:K730	R:R:T649	3	No	Yes	0	2	3
230	R:R:K728	R:R:T658	3	Yes	No	0	5	6
231	R:R:K768	R:R:T767	3	No	No	0	8	4
232	R:R:L769	R:R:S792	3	No	No	0	7	8
233	R:R:L676	R:R:V757	2.98	Yes	No	0	7	7
234	R:R:L711	R:R:V715	2.98	No	No	0	7	6
235	R:R:L769	R:R:V789	2.98	No	Yes	0	7	8
236	R:R:L793	R:R:T797	2.95	No	No	0	7	9
237	R:R:I606	R:R:I839	2.94	No	No	0	8	7
238	R:R:A746	R:R:H665	2.93	No	Yes	0	9	9
239	R:R:I630	R:R:M675	2.92	No	Yes	0	8	9
240	R:R:D648	R:R:V651	2.92	No	No	0	5	1
241	R:R:I786	R:R:K783	2.91	No	No	0	6	6
242	R:R:F833	R:R:P798	2.89	No	No	0	7	9
243	R:R:I614	R:R:L848	2.85	No	No	0	7	7
244	R:R:I636	R:R:L632	2.85	No	No	0	7	5
245	R:R:I713	R:R:L669	2.85	No	Yes	0	9	9
246	R:R:I795	R:R:L841	2.85	No	No	0	7	5
247	R:R:I834	R:R:L799	2.85	No	No	0	9	6
248	R:R:K791	R:R:L841	2.82	No	No	0	8	5
249	R:R:G809	R:R:W819	2.81	No	No	0	7	6
250	R:R:A828	R:R:F569	2.77	No	Yes	0	8	9
251	R:R:L678	R:R:L682	2.77	No	No	0	8	9
252	R:R:D731	R:R:K730	2.77	No	No	0	3	2
253	R:R:N851	R:R:Q847	2.64	No	No	0	4	6
254	R:R:A660	R:R:W640	2.59	No	No	0	7	6
255	R:R:A683	W:W:?1	2.59	No	Yes	0	6	0
256	R:R:T589	R:R:Y590	2.5	No	Yes	0	9	5
257	R:R:V628	R:R:W611	2.45	No	No	0	7	9
258	R:R:V643	R:R:W640	2.45	No	No	0	8	6
259	R:R:V701	W:W:?1	2.45	No	Yes	0	6	0
260	R:R:I642	R:R:Y590	2.42	No	Yes	0	8	5
261	R:R:K586	R:R:Y590	2.39	No	Yes	0	3	5
262	R:R:I786	R:R:W770	2.35	No	No	0	6	6
263	R:R:F610	R:R:Q613	2.34	Yes	No	0	8	5
264	R:R:A660	R:R:G644	1.95	No	No	0	7	6
265	R:R:G831	R:R:S599	1.86	No	No	0	9	8
266	R:R:G740	R:R:S738	1.86	No	No	0	4	2
267	R:R:G592	R:R:V591	1.84	No	No	0	9	7
268	R:R:G644	R:R:V647	1.84	No	No	0	6	5
269	R:R:G679	R:R:V761	1.84	No	No	0	9	8
270	R:R:G805	R:R:V755	1.84	No	No	0	6	8
271	R:R:G790	R:R:V789	1.84	No	Yes	0	5	8
272	R:R:G809	R:R:V812	1.84	No	No	0	7	6
273	R:R:A567	R:R:A645	1.79	No	No	0	9	7
274	R:R:G598	R:R:I597	1.76	No	No	0	3	7
275	R:R:G598	R:R:I601	1.76	No	No	0	3	5
276	R:R:G809	R:R:I808	1.76	No	No	0	7	7
277	R:R:P578	R:R:T580	1.75	Yes	No	0	4	3
278	R:R:G708	R:R:L711	1.71	No	No	0	6	7
279	R:R:A824	R:R:V585	1.7	No	No	0	8	8
280	R:R:C603	R:R:I839	1.64	No	No	0	7	7
281	R:R:N652	R:R:P653	1.63	No	No	0	4	4
282	R:R:S792	R:R:V765	1.62	No	No	0	8	9
283	R:R:T650	R:R:V651	1.59	No	No	0	3	1
284	R:R:T721	R:R:V720	1.59	Yes	No	0	9	5
285	R:R:A631	R:R:L600	1.58	No	No	0	8	9
286	R:R:A694	R:R:L697	1.58	No	No	0	8	3
287	R:R:A751	R:R:L752	1.58	No	No	0	9	8
288	R:R:I581	R:R:V821	1.54	Yes	No	0	4	7
289	R:R:I588	R:R:V821	1.54	No	No	0	9	7
290	R:R:I636	R:R:V639	1.54	No	No	0	7	6
291	R:R:I642	R:R:V639	1.54	No	No	0	8	6
292	R:R:I716	R:R:V715	1.54	No	No	0	7	6
293	R:R:A784	R:R:D781	1.54	No	No	0	6	6
294	R:R:N739	R:R:S738	1.49	No	No	0	4	2
295	R:R:I601	R:R:I605	1.47	No	No	0	5	6
296	R:R:I581	R:R:L817	1.43	Yes	No	0	4	2
297	R:R:D782	R:R:K783	1.38	No	No	0	7	6
298	R:R:K612	R:R:Q613	1.36	Yes	No	0	7	5
299	R:R:A567	R:R:Y590	1.33	No	Yes	0	9	5
300	R:R:F576	R:R:S814	1.32	No	No	0	3	5
301	R:R:A818	R:R:W819	1.3	No	No	0	6	6
302	R:R:V755	R:R:W804	1.23	No	Yes	0	8	9
303	R:R:F610	R:R:L609	1.22	Yes	No	0	8	4
304	R:R:F759	R:R:L802	1.22	No	No	0	4	7
305	R:R:L778	R:R:R780	1.21	No	No	0	5	3

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	R:R:F569	4.872	5	2	9
2	R:R:S570	5.0525	4	3	9
3	R:R:L572	5.105	4	2	9
4	R:R:S574	3.9725	4	3	9
5	R:R:P575	7.695	4	3	6
6	R:R:P578	4.1575	4	0	4
7	R:R:I581	3.79	5	0	4
8	R:R:Y590	2.16	4	0	5
9	R:R:F610	3.9525	4	0	8
10	R:R:K612	5.93	4	5	7
11	R:R:K615	10.64	4	5	8
12	R:R:R624	7.6525	4	0	9
13	R:R:D638	5.6475	4	0	7
14	R:R:T649	3.9875	4	4	3
15	R:R:H665	5.37333	6	0	9
16	R:R:Y668	4.702	5	2	8
17	R:R:L669	4.6025	4	0	9
18	R:R:F672	8.205	4	0	9
19	R:R:W674	9.05833	6	1	9
20	R:R:M675	3.595	4	0	9
21	R:R:L676	4.66	4	0	7
22	R:R:M677	5.234	5	1	6
23	R:R:Y684	6.924	5	1	8
24	R:R:R685	7.778	5	1	8
25	R:R:H691	6.86	4	1	7
26	R:R:T721	5.195	4	0	9
27	R:R:T726	3.8975	4	0	4
28	R:R:Y727	5.835	6	2	9
29	R:R:K728	4.655	4	4	5
30	R:R:W734	5.34167	6	2	8
31	R:R:L735	5.252	5	2	9
32	R:R:L744	5.0025	4	2	8
33	R:R:F747	5.416	5	2	8
34	R:R:V789	3.2425	4	0	8
35	R:R:W804	9.332	5	7	9
36	R:R:H820	5.2975	4	3	8
37	W:W:?1	5.32154	13	1	0

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:F747	R:R:L572	10.1112	3.65	Yes	Yes	2	8	9
2	R:R:L744	R:R:W737	16.058	6.83	Yes	No	0	8	6
3	R:R:P575	R:R:W737	13.9108	20.27	Yes	No	0	6	6
4	R:R:P575	R:R:S574	12.0577	3.56	Yes	Yes	3	6	9
5	R:R:D638	R:R:Y668	17.3377	4.6	Yes	Yes	0	7	8
6	R:R:F747	R:R:Y668	17.3973	4.13	Yes	Yes	2	8	8
7	R:R:F832	R:R:F833	10.5883	6.43	No	No	0	5	7
8	R:R:F833	R:R:P798	11.3244	2.89	No	No	0	7	9
9	R:R:P798	R:R:T797	12.0577	3.5	No	No	0	9	9
10	R:R:L802	R:R:T797	22.0401	8.84	No	No	0	7	9
11	R:R:L802	R:R:V762	24.1101	4.47	No	No	0	7	8
12	R:R:L796	R:R:V762	24.7946	4.47	No	No	0	9	8
13	R:R:L796	R:R:L800	25.4765	6.92	No	No	0	9	9
14	R:R:L800	R:R:N758	26.1556	10.98	No	No	0	9	9
15	R:R:I754	R:R:N758	26.832	4.25	No	No	0	9	9
16	R:R:I754	R:R:L676	27.5058	7.14	No	Yes	0	9	7
17	R:R:L676	R:R:M677	20.389	4.24	Yes	Yes	0	7	6
18	R:R:L705	R:R:M677	55.0278	5.65	No	Yes	0	6	6
19	R:R:F673	R:R:L705	55.0169	6.09	No	No	0	8	6
20	R:R:F673	R:R:P710	54.9953	11.56	No	No	0	8	9
21	R:R:L669	R:R:P710	100	3.28	Yes	No	0	9	9
22	R:R:H665	R:R:L669	98.9847	9	Yes	Yes	0	9	9
23	R:R:H665	R:R:L735	42.2313	3.86	Yes	Yes	0	9	9
24	R:R:L735	R:R:L744	19.1257	4.15	Yes	Yes	2	9	8
25	R:R:R624	R:R:S620	68.6661	3.95	Yes	No	0	9	8
26	R:R:S617	R:R:S620	71.3949	3.26	No	No	0	8	8
27	R:R:S617	R:R:T619	74.1209	4.8	No	No	0	8	8
28	R:R:R685	R:R:T619	76.7195	12.94	Yes	No	0	8	8
29	R:R:L681	R:R:R685	22.6271	4.86	No	Yes	0	7	8
30	R:R:L681	R:R:T622	23.2615	7.37	No	No	0	7	7
31	R:R:T622	W:W:?1	23.8972	4.85	No	Yes	0	7	0
32	R:R:W674	W:W:?1	44.0802	3.75	Yes	Yes	1	9	0
33	R:R:W674	R:R:Y707	44.4923	7.72	Yes	No	1	9	9
34	R:R:S670	R:R:Y707	45.3003	3.82	No	No	0	8	9
35	R:R:P710	R:R:S670	45.2731	3.56	No	No	0	9	8
36	R:R:R685	R:R:Y684	67.5247	10.29	Yes	Yes	1	8	8
37	R:R:L688	R:R:Y684	23.843	7.03	No	Yes	1	6	8
38	R:R:L688	W:W:?1	24.4829	9.11	No	Yes	1	6	0
39	R:R:H691	R:R:Y684	23.8417	6.53	Yes	Yes	1	7	8
40	R:R:H691	W:W:?1	24.4815	5.29	Yes	Yes	1	7	0
41	R:R:M693	R:R:Y684	23.8674	7.18	No	Yes	1	5	8
42	R:R:M693	W:W:?1	24.5154	3.49	No	Yes	1	5	0
43	R:R:M677	W:W:?1	52.1513	8.14	Yes	Yes	1	6	0
44	R:R:K615	R:R:R624	46.8266	9.9	Yes	Yes	0	8	9
45	R:R:F610	R:R:Q613	27.5302	2.34	Yes	No	0	8	5
46	R:R:K612	R:R:Q613	30.2982	1.36	Yes	No	0	7	5
47	R:R:K612	R:R:K615	35.8086	5.75	Yes	Yes	5	7	8
48	R:R:F610	R:R:L848	13.7956	8.53	Yes	No	0	8	7
49	R:R:I614	R:R:L848	11.1604	2.85	No	No	0	7	7
50	R:R:Q618	R:R:R685	11.0411	5.84	No	Yes	0	7	8
51	R:R:R623	R:R:R624	11.1685	7.46	No	Yes	0	9	9
52	R:R:F672	R:R:F747	18.6553	7.5	Yes	Yes	0	9	8
53	R:R:H665	R:R:S714	17.0245	4.18	Yes	No	0	9	9
54	R:R:K728	R:R:V661	13.0649	3.04	Yes	No	0	5	8
55	R:R:V661	R:R:Y727	14.5032	6.31	No	Yes	0	8	9
56	R:R:L735	R:R:Y727	18.4045	5.86	Yes	Yes	2	9	9
57	R:R:H665	R:R:T717	15.2298	5.48	Yes	No	0	9	9
58	R:R:T717	R:R:Y727	14.6143	4.99	No	Yes	0	9	9
59	R:R:T721	R:R:Y727	13.0609	3.75	Yes	Yes	0	9	9
60	R:R:S741	R:R:T721	15.7503	3.2	No	Yes	0	8	9
61	R:R:S741	R:R:T726	13.5082	3.2	No	Yes	0	8	4
62	R:R:F747	R:R:H665	42.5471	6.79	Yes	Yes	0	8	9

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:L681	R:R:T622	7.37	0	No	No	7	7	2	1
R:R:T622	W:W:?1	4.85	0	No	Yes	7	0	1	0
R:R:I625	R:R:M699	4.37	0	No	No	7	7	1	2
R:R:I625	W:W:?1	4.7	0	No	Yes	7	0	1	0
R:R:C626	W:W:?1	3.92	0	No	Yes	7	0	1	0
R:R:N629	R:R:W674	25.99	1	No	Yes	9	9	2	1
R:R:F703	R:R:N629	8.46	1	No	No	8	9	2	2
R:R:N629	R:R:Y707	4.65	1	No	No	9	9	2	2
R:R:M677	R:R:W674	4.65	1	Yes	Yes	6	9	1	1
R:R:F703	R:R:W674	8.02	1	No	Yes	8	9	2	1
R:R:G706	R:R:W674	4.22	0	No	Yes	9	9	2	1
R:R:W674	R:R:Y707	7.72	1	Yes	No	9	9	1	2
R:R:W674	W:W:?1	3.75	1	Yes	Yes	9	0	1	0
R:R:L676	R:R:M677	4.24	0	Yes	Yes	7	6	2	1
R:R:I680	R:R:L676	4.28	0	No	Yes	8	7	1	2
R:R:G702	R:R:M677	3.49	1	No	Yes	7	6	1	1
R:R:L705	R:R:M677	5.65	0	No	Yes	6	6	2	1
R:R:M677	W:W:?1	8.14	1	Yes	Yes	6	0	1	0
R:R:I680	W:W:?1	5.87	0	No	Yes	8	0	1	0
R:R:A683	R:R:V761	3.39	0	No	No	6	8	1	2
R:R:L688	R:R:Y684	7.03	1	No	Yes	6	8	1	2
R:R:H691	R:R:Y684	6.53	1	Yes	Yes	7	8	1	2
R:R:M693	R:R:Y684	7.18	1	No	Yes	5	8	1	2
R:R:I687	R:R:L764	4.28	0	No	No	6	7	1	2
R:R:I687	W:W:?1	9.39	0	No	Yes	6	0	1	0
R:R:H691	R:R:L688	6.43	1	Yes	No	7	6	1	1
R:R:L688	W:W:?1	9.11	1	No	Yes	6	0	1	0
R:R:H691	R:R:M693	9.19	1	Yes	No	7	5	1	1
R:R:H691	W:W:?1	5.29	1	Yes	Yes	7	0	1	0
R:R:M693	W:W:?1	3.49	1	No	Yes	5	0	1	0
R:R:F703	R:R:M699	6.22	1	No	No	8	7	2	2
R:R:G702	W:W:?1	5.63	1	No	Yes	7	0	1	0
R:R:C626	R:R:L678	3.17	0	No	No	7	8	1	2
R:R:A683	W:W:?1	2.59	0	No	Yes	6	0	1	0
R:R:V701	W:W:?1	2.45	0	No	Yes	6	0	1	0

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	7WU5_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	3.26
Number of Linked Nodes	273
Number of Links	305
Number of Hubs	37
Number of Links mediated by Hubs	141
Number of Communities	7
Number of Nodes involved in Communities	42
Number of Links involved in Communities	55

Path Summary
Number Of Nodes in MetaPath	63
Number Of Links MetaPath	62
Number of Shortest Paths	112335
Length Of Smallest Path	3
Average Path Length	18.0067
Length of Longest Path	35
Minimum Path Strength	1.485
Average Path Strength	5.97064
Maximum Path Strength	17.06
Minimum Path Correlation	0.7
Average Path Correlation	0.942855
Maximum Path Correlation	1
Minimum % Of Corr. Nodes	3.125
Average % Of Corr. Nodes	43.6243
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	44.571
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function	• D2 dopamine receptor binding • protein binding • binding • signaling receptor binding • G protein-coupled receptor binding • dopamine receptor binding • enzyme regulator activity • adenylate cyclase inhibitor activity • cyclase regulator activity • molecular function inhibitor activity • cyclase inhibitor activity • molecular function regulator activity • enzyme inhibitor activity • adenylate cyclase regulator activity • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • cation binding • magnesium ion binding • metal ion binding • GDP binding • G protein-coupled serotonin receptor binding • protein-containing complex binding • G-protein beta/gamma-subunit complex binding • pyrophosphatase activity • GTPase activity • G protein activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • adenylate cyclase-inhibiting serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • cell communication • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular process • signal transduction
Gene Ontology	Biological Process	• cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • adenylate cyclase-inhibiting serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • cell communication • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular process • signal transduction • response to hormone • response to chemical • response to endogenous stimulus • response to peptide hormone • response to oxygen-containing compound • response to nitrogen compound • cell division • leukocyte migration • immune system process • mononuclear cell migration • lymphocyte migration • cell migration • T cell migration • cell motility • regulation of steroid biosynthetic process • regulation of cholesterol biosynthetic process • regulation of cholesterol metabolic process • steroid metabolic process • regulation of lipid metabolic process • sterol metabolic process • positive regulation of biological process • cholesterol metabolic process • lipid biosynthetic process • alcohol metabolic process • regulation of primary metabolic process • positive regulation of metabolic process • regulation of small molecule metabolic process • positive regulation of biosynthetic process • positive regulation of lipid metabolic process • small molecule metabolic process • steroid biosynthetic process • positive regulation of cellular process • regulation of biosynthetic process • secondary alcohol biosynthetic process • regulation of alcohol biosynthetic process • small molecule biosynthetic process • regulation of steroid metabolic process • cholesterol biosynthetic process • positive regulation of cholesterol biosynthetic process • primary metabolic process • secondary alcohol metabolic process • positive regulation of steroid biosynthetic process • biosynthetic process • sterol biosynthetic process • positive regulation of lipid biosynthetic process • regulation of sterol biosynthetic process • alcohol biosynthetic process • positive regulation of cholesterol metabolic process • positive regulation of steroid metabolic process • metabolic process • regulation of lipid biosynthetic process • positive regulation of small molecule metabolic process • regulation of metabolic process • positive regulation of alcohol biosynthetic process • positive regulation of sterol biosynthetic process • lipid metabolic process • negative regulation of protein transport • regulation of localization • establishment of protein localization • nitrogen compound transport • negative regulation of biological process • negative regulation of transport • localization • negative regulation of secretion • negative regulation of hormone secretion • negative regulation of secretion by cell • intracellular protein localization • regulation of biological quality • regulation of peptide hormone secretion • negative regulation of peptide hormone secretion • regulation of hormone levels • establishment of protein localization to extracellular region • negative regulation of establishment of protein localization • protein secretion • establishment of localization • regulation of protein secretion • regulation of secretion • negative regulation of protein secretion • regulation of hormone secretion • regulation of protein localization • regulation of peptide secretion • transport • negative regulation of signaling • hormone secretion • negative regulation of cell communication • protein localization to extracellular region • negative regulation of peptide secretion • peptide secretion • regulation of secretion by cell • secretion by cell • amide transport • signal release • negative regulation of cellular process • negative regulation of protein localization • regulation of signaling • regulation of transport • secretion • regulation of peptide transport • regulation of establishment of protein localization • export from cell • cell-cell signaling • regulation of protein transport • peptide transport • negative regulation of insulin secretion • protein transport • regulation of insulin secretion • peptide hormone secretion • macromolecule localization • hormone transport • regulation of cell communication • insulin secretion • regulation of cytoskeleton organization • regulation of cellular component organization • microtubule cytoskeleton organization • regulation of mitotic spindle organization • mitotic cell cycle • cellular component organization • cell cycle • cellular component organization or biogenesis • regulation of cell cycle • microtubule cytoskeleton organization involved in mitosis • spindle organization • cell cycle process • regulation of cell cycle process • regulation of microtubule-based process • regulation of spindle organization • regulation of organelle organization • mitotic spindle organization • organelle organization • mitotic cell cycle process • microtubule-based process • cytoskeleton organization • regulation of microtubule cytoskeleton organization • positive regulation of protein localization to cell periphery • protein localization to cell periphery • positive regulation of protein localization to cell cortex • regulation of protein localization to cell periphery • regulation of protein localization to cell cortex • positive regulation of protein localization • protein localization to cell cortex • response to ketone • response to prostaglandin • response to lipid • response to alcohol • response to prostaglandin E • cellular response to forskolin • cellular response to oxygen-containing compound • cellular response to chemical stimulus • cellular response to alcohol • response to forskolin • cellular response to lipid • cellular response to ketone • midbody • cellular anatomical structure • membrane-bounded organelle • intracellular anatomical structure • nucleus • membrane-enclosed lumen • intracellular membraneless organelle • intracellular membrane-bounded organelle • nucleolus • intracellular organelle lumen • intracellular organelle • organelle lumen • organelle • membraneless organelle
Gene Ontology	Cellular Component	• midbody • cellular anatomical structure • membrane-bounded organelle • intracellular anatomical structure • nucleus • membrane-enclosed lumen • intracellular membraneless organelle • intracellular membrane-bounded organelle • nucleolus • intracellular organelle lumen • intracellular organelle • organelle lumen • organelle • membraneless organelle • nuclear lumen • cell periphery • cell cortex • cytoplasm • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • extracellular vesicle • extracellular organelle • extracellular region • extracellular space • vesicle • extracellular membrane-bounded organelle • centrosome • microtubule organizing center • cytoskeleton • microtubule cytoskeleton • centriolar satellite • cytosol • nucleoplasm • vacuolar membrane • lytic vacuole • vacuole • lytic vacuole membrane • bounding membrane of organelle • lysosomal membrane • organelle membrane • lysosome • Golgi apparatus • endomembrane system • cilium • plasma membrane bounded cell projection • ciliary basal body • cell projection • protein binding • binding • enzyme binding • GTPase binding • protein-containing complex binding • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • multicellular organismal process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development • anatomical structure development • sensory system development • system development • cell population proliferation • cellular process • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • signal transduction • cell communication • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • response to oxygen-containing compound • cellular response to oxygen-containing compound • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to chemical stimulus • cellular response to alcohol • response to hormone • response to chemical • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • small GTPase-mediated signal transduction • Ras protein signal transduction • intracellular signal transduction • intracellular signaling cassette • phospholipase C-activating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular response to nitrogen compound • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • response to nitrogen compound • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to monoamine stimulus • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • synaptic signaling • cellular response to acetylcholine • cell-cell signaling • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • non-motile cilium • 9+0 non-motile cilium • neuron projection • photoreceptor disc membrane • photoreceptor outer segment • photoreceptor cell cilium • synapse • cell junction • G-protein beta-subunit binding • fibroblast proliferation • molecular transducer activity • G protein-coupled receptor activity • transmembrane signaling receptor activity • signaling receptor activity • cell surface receptor signaling pathway • regulation of lipid metabolic process • primary metabolic process • metabolic process • regulation of metabolic process • lipid metabolic process • regulation of primary metabolic process • fat cell differentiation • cellular developmental process • cell differentiation • behavior • learning or memory • cognition • memory • nervous system development • cellular component organization • cellular component biogenesis • cell junction organization • cellular component assembly • cell junction assembly • synapse organization • cellular component organization or biogenesis • synapse assembly • energy derivation by oxidation of organic compounds • energy reserve metabolic process • generation of precursor metabolites and energy • plasma membrane bounded cell projection organization • cell projection organization • cell development • neuron projection development • generation of neurons • neurogenesis • neuron differentiation • neuron development • cytoplasmic vesicle • intracellular vesicle
SCOP2	Domain Identifier	• Ras-like P-loop GTPases • Transducin (heterotrimeric G protein), gamma chain
SCOP2	Family Identifier	• Ras-like P-loop GTPases • Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	K6G
PDB Residues	W:W:?1
Environment Details	Open EMBL-EBI Page
Code	K6G
Name	[(2~{R})-2-oxidanyl-3-[oxidanyl-[2-(trimethyl-$l^{4}-azanyl)ethoxy]phosphoryl]oxy-propyl] hexadecanoate
Synonyms
Identifier
Formula	C24 H51 N O7 P
Molecular Weight	496.638
SMILES
PubChem
Formal Charge	0
Total Atoms	84
Total Chiral Atoms	1
Total Bonds	83
Total Aromatic Bonds	0


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	Q5T601
Sequence	>7WU5_nogp_Chain_R A S F S I L M S P F V P S T I F P V V K W I T Y V G L G I S I G S L I L C L I I E A L F W K Q I K K S Q T S H T R R I C M V N I A L S L L I A D V W F I V G A T V D T T V N P S G V C T A A V F F T H F F Y L S L F F W M L M L G I L L A Y R I I L V F H H M A Q H L M M A V G F C L G Y G C P L I I S V I T I A V T Q P S N T Y K R K D V C W L N W S N G S K P L L A F V V P A L A I V A V N F V V V L L V L T K L W R P T V G E R L S R D D K A T I I R V G K S L L I L T P L L G L T W G F G I G T I V D S Q N L A W H V I F A L L N A F Q G F F I L C F G I L L D S K L R Q L L F N K Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	8G2Y	B2	Adhesion	Adhesion	ADGRF1	Homo sapiens	-	LPC	chim(Gs-CtGq)/β1/γ2	3.44	2023-05-10	doi.org/10.1038/s41467-023-38083-7
	8G2Y (No Gprot)	B2	Adhesion	Adhesion	ADGRF1	Homo sapiens	-	LPC		3.44	2023-05-10	doi.org/10.1038/s41467-023-38083-7
	7WU3	B2	Adhesion	Adhesion	ADGRF1	Homo sapiens	-	K6G	Gs/β1/γ2	3.1	2022-04-27	doi.org/10.1038/s41586-022-04580-w
	7WU3 (No Gprot)	B2	Adhesion	Adhesion	ADGRF1	Homo sapiens	-	K6G		3.1	2022-04-27	doi.org/10.1038/s41586-022-04580-w
	7WU4	B2	Adhesion	Adhesion	ADGRF1	Homo sapiens	-	K6G	Gi1/β1/γ2	3.4	2022-04-27	doi.org/10.1038/s41586-022-04580-w
	7WU4 (No Gprot)	B2	Adhesion	Adhesion	ADGRF1	Homo sapiens	-	K6G		3.4	2022-04-27	doi.org/10.1038/s41586-022-04580-w
	7WU5	B2	Adhesion	Adhesion	ADGRF1	Homo sapiens	-	K6G	Gi1/β1/γ2	3	2022-04-27	doi.org/10.1038/s41586-022-04580-w
	7WU5 (No Gprot)	B2	Adhesion	Adhesion	ADGRF1	Homo sapiens	-	K6G		3	2022-04-27	doi.org/10.1038/s41586-022-04580-w
	7WXU	B2	Adhesion	Adhesion	ADGRF1	Homo sapiens	-	-	chim(NtGi1-Gs-CtGq)/β1/γ2	2.85	2022-09-28	doi.org/10.1038/s41467-022-33173-4
	7WXU (No Gprot)	B2	Adhesion	Adhesion	ADGRF1	Homo sapiens	-	-		2.85	2022-09-28	doi.org/10.1038/s41467-022-33173-4
	7WXW	B2	Adhesion	Adhesion	ADGRF1	Homo sapiens	-	-	chim(NtGi1-Gs)/β1/γ2	2.84	2022-09-28	doi.org/10.1038/s41467-022-33173-4
	7WXW (No Gprot)	B2	Adhesion	Adhesion	ADGRF1	Homo sapiens	-	-		2.84	2022-09-28	doi.org/10.1038/s41467-022-33173-4
	7WY0	B2	Adhesion	Adhesion	ADGRF1	Homo sapiens	-	-	chim(NtGi1L-G13)/β1/γ2	2.83	2022-09-28	doi.org/10.1038/s41467-022-33173-4
	7WY0 (No Gprot)	B2	Adhesion	Adhesion	ADGRF1	Homo sapiens	-	-		2.83	2022-09-28	doi.org/10.1038/s41467-022-33173-4
	7WZ7	B2	Adhesion	Adhesion	ADGRF1	Homo sapiens	-	-	chim(NtGi1-G12)/β1/γ2	2.83	2022-09-28	doi.org/10.1038/s41467-022-33173-4
	7WZ7 (No Gprot)	B2	Adhesion	Adhesion	ADGRF1	Homo sapiens	-	-		2.83	2022-09-28	doi.org/10.1038/s41467-022-33173-4
	7X2V	B2	Adhesion	Adhesion	ADGRF1	Homo sapiens	-	-	Gi1/β1/γ2	3.09	2022-09-28	doi.org/10.1038/s41467-022-33173-4
	7X2V (No Gprot)	B2	Adhesion	Adhesion	ADGRF1	Homo sapiens	-	-		3.09	2022-09-28	doi.org/10.1038/s41467-022-33173-4

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