Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg Int. Strength Num Of Links Community ConSurf
1A:A:Y63 6.2625419
2A:A:V214 3.895416
3A:A:F219 6.255418
4A:A:K233 2.99479
5A:A:W234 4.435409
6A:A:F246 3.83509
7A:A:V248 2.48407
8A:A:D249 7.22754148
9A:A:Y253 6.4275408
10A:A:F273 3.884189
11A:A:W277 6.355186
12A:A:W281 8.085455
13A:A:I285 2.62407
14A:A:F290 4.7125419
15A:A:N292 4.685419
16A:A:Y311 2.4175406
17A:A:F312 2.2785138
18A:A:F315 6.9025406
19A:A:P321 3.62754105
20A:A:E330 4.4625403
21A:A:K338 5.42254105
22A:A:Y339 5.345103
23A:A:F340 5.7165137
24A:A:F345 4.735408
25A:A:S349 3.795407
26A:A:Y360 7.3625408
27A:A:F363 6.1754105
28A:A:T364 4.785419
29A:A:R373 4.802515
30A:A:R374 4.486514
31A:A:F376 3.53375818
32A:A:I382 2.535406
33B:B:L4 3.94504
34B:B:D27 5.07408
35B:B:T34 2.635405
36B:B:V40 3.2265233
37B:B:R48 3.7325407
38B:B:H54 6.8025409
39B:B:L55 4.234126
40B:B:K57 8.082559
41B:B:Y59 5.624558
42B:B:W63 5.45667607
43B:B:D76 3.3525129
44B:B:W82 8.3925409
45B:B:D83 5.9725488
46B:B:Y85 8.1575484
47B:B:K89 5.5725409
48B:B:H91 5.1245115
49B:B:I93 3.3175407
50B:B:W99 5.30286709
51B:B:Y105 3.294506
52B:B:N110 6.19254154
53B:B:Y111 5.43254154
54B:B:Y124 4.242506
55B:B:T128 5.71254263
56B:B:E130 5.74263
57B:B:H142 6.02286799
58B:B:Y145 3.61857778
59B:B:F151 4.692509
60B:B:L152 3.2075403
61B:B:D163 7.765499
62B:B:W169 7.86167698
63B:B:I171 3.56406
64B:B:F180 4.752547
65B:B:H183 6.896549
66B:B:F199 4.854549
67B:B:V200 5.5575426
68B:B:K209 7.8625446
69B:B:W211 6.632548
70B:B:C218 3.715445
71B:B:Q220 5.3425427
72B:B:F222 4.61628
73B:B:H225 7.59167629
74B:B:D228 5.516579
75B:B:I232 4.785428
76B:B:F234 6.05405
77B:B:F235 5.91833636
78B:B:F241 4.95429726
79B:B:T243 4.18667628
80B:B:D247 7.9075429
81B:B:R251 8.0325428
82B:B:F253 6.035426
83B:B:D258 7.055427
84B:B:Y264 4.85735
85B:B:F278 5.4425437
86B:B:R283 7.0354239
87B:B:Y289 4.70667637
88B:B:W297 3.298538
89B:B:R304 3.7725435
90B:B:H311 7.335289
91B:B:R314 11.144558
92B:B:V320 3.24754277
93B:B:T321 6.234257
94B:B:W332 8.44714759
95B:B:D333 5.29254289
96B:B:W339 5.9185249
97G:G:D48 4.662509
98G:G:N59 4.6775489
99G:G:F61 3.74286788
100R:R:F569 2.928509
101R:R:S570 4.5725469
102R:R:S574 4.056569
103R:R:V577 3.1125463
104R:R:Y590 5.55754295
105R:R:L593 2.944508
106R:R:L600 2.98409
107R:R:F610 5.49754318
108R:R:R624 5.54754209
109R:R:M627 3.0054207
110R:R:N629 8.18254169
111R:R:W640 5.23406
112R:R:F662 3.7565338
113R:R:H665 3.1775409
114R:R:F666 6.0325407
115R:R:Y668 3.99408
116R:R:L669 2.9425409
117R:R:F672 4.9925409
118R:R:W674 7.6185169
119R:R:I686 2.892507
120R:R:F690 4.79418
121R:R:Y707 5.85254169
122R:R:P710 2.88409
123R:R:Y727 5.1025339
124R:R:V762 1.49508
125R:R:P798 2.5509
126R:R:W804 4.80254309
127R:R:T810 4.776567
128R:R:W819 6.692566
129R:R:H820 5.10167668
130R:R:F823 6.70754309
131R:R:F837 3.4275408
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
1B:B:L69 B:B:Y105 16.65862.34NoYes056
2B:B:D83 B:B:L69 16.80872.71YesNo085
3A:A:Y37 B:B:D76 63.49872.3NoYes1249
4A:A:R42 A:A:Y37 63.6713.38NoNo094
5A:A:F222 A:A:R42 62.62412.14NoNo079
6A:A:F222 B:B:W99 62.269212.03NoYes079
7B:B:D83 B:B:Y85 16.62152.3YesYes884
8B:B:Y85 G:G:F61 16.66365.16YesYes848
9B:B:S84 G:G:F61 18.51682.64NoYes858
10B:B:S84 B:B:W63 19.37612.47NoYes057
11B:B:M61 B:B:W63 86.90965.82NoYes067
12B:B:C317 B:B:M61 86.78424.86NoNo076
13B:B:C317 B:B:G330 86.65831.96NoNo075
14B:B:G330 B:B:T329 86.5321.82NoNo058
15B:B:H311 B:B:T329 83.91125.48YesNo098
16B:B:D333 B:B:H311 83.30155.04YesYes2899
17B:B:D312 B:B:D333 82.78243.99NoYes059
18B:B:D312 R:R:Q613 82.49972.61NoNo055
19R:R:L848 R:R:Q613 82.2162.66NoNo075
20R:R:F610 R:R:L848 81.78613.65YesNo087
21R:R:F610 R:R:I606 80.81812.51YesNo3188
22R:R:E607 R:R:I606 80.91412.73NoNo098
23R:R:E607 R:R:R624 79.876111.63NoYes099
24R:R:R623 R:R:R624 33.18573.2NoYes2099
25A:A:Y391 R:R:R623 35.04328.23NoNo049
26A:A:F376 R:R:F690 25.17136.43YesYes188
27A:A:I383 R:R:F690 26.00763.77NoYes088
28A:A:I383 R:R:V689 26.26953.07NoNo089
29A:A:L384 R:R:V689 26.53141.49NoNo069
30A:A:L384 R:R:I686 26.79384.28NoYes067
31R:R:I686 R:R:L682 29.75562.85YesNo079
32A:A:Y391 R:R:L682 30.21782.34NoNo049
33A:A:F238 B:B:W99 39.11616.01NoYes099
34A:A:F212 A:A:M60 14.83814.98NoNo099
35B:B:L117 B:B:W99 19.13533.42NoYes099
36A:A:F238 A:A:W234 38.50082NoYes099
37B:B:L117 B:B:Y145 16.93843.52NoYes798
38B:B:D186 B:B:Y145 16.39994.6NoYes098
39A:A:R231 A:A:W234 39.69454NoYes099
40A:A:D272 A:A:R231 39.45543.57NoNo089
41A:A:D272 A:A:F246 39.21668.36NoYes089
42A:A:F246 A:A:V248 19.93982.62YesYes097
43A:A:F246 A:A:F273 10.01633.22YesYes099
44A:A:L291 A:A:V248 11.1292.98NoYes087
45A:A:F345 A:A:L270 17.49267.31YesNo086
46A:A:L270 A:A:Q267 14.17383.99NoNo064
47A:A:F312 A:A:Q267 13.34822.34YesNo084
48R:R:L802 R:R:V762 10.62081.49NoYes078
49R:R:L802 R:R:T797 10.85582.95NoNo079
50R:R:P798 R:R:T797 11.09553.5YesNo099
51R:R:L799 R:R:P798 47.08181.64NoYes069
52R:R:L799 R:R:M627 47.29462.83NoYes067
53R:R:M627 R:R:R624 45.633.72YesYes2079
54A:A:F363 A:A:L291 10.84872.44YesNo058
55B:B:T321 B:B:W63 10010.92YesYes077
56B:B:G324 B:B:T321 99.50581.82NoYes097
57B:B:G324 G:G:P49 99.44244.06NoNo097
58G:G:D48 G:G:P49 99.74243.22YesNo097
59B:B:S281 G:G:D48 74.41035.89NoYes099
60B:B:S281 G:G:H44 74.30712.79NoNo096
61G:G:H44 G:G:Y40 74.100610.89NoNo066
62B:B:P236 G:G:Y40 36.62164.17NoNo076
63B:B:F235 B:B:P236 36.288310.11YesNo367
64B:B:F235 B:B:F278 71.86587.5YesYes367
65B:B:C233 B:B:F278 32.1534.19NoYes037
66B:B:C233 B:B:V276 31.79261.71NoNo036
67B:B:C250 B:B:V276 31.09761.71NoNo086
68B:B:C250 B:B:G244 77.22361.96NoNo085
69B:B:G244 B:B:T243 75.66811.82NoYes058
70B:B:F241 B:B:T243 31.68192.59YesYes268
71B:B:F222 B:B:F241 11.56437.5YesYes286
72B:B:D258 B:B:F222 17.32624.78YesYes278
73B:B:N237 G:G:Y40 37.38513.49NoNo056
74B:B:F235 B:B:N237 36.53087.25YesNo065
75B:B:F278 B:B:L285 39.02717.31YesNo376
76B:B:L285 B:B:Y264 38.70833.52NoYes365
77B:B:C250 B:B:Y264 47.13325.38NoYes085
78G:G:D48 G:G:L51 25.29084.07YesNo096
79B:B:V40 G:G:L51 24.80192.98YesNo036
80B:B:R283 B:B:V40 23.55225.23YesYes2393
81B:B:I37 B:B:R283 23.09653.76NoYes029
82B:B:I37 B:B:T34 23.0533.04NoYes025
83B:B:L30 B:B:T34 20.44872.95NoYes055
84B:B:L30 B:B:M262 20.28335.65NoNo054
85B:B:M262 B:B:Y264 19.92410.78NoYes345
86B:B:F253 B:B:T243 14.38987.78YesYes268
87B:B:F222 B:B:F253 11.53172.14YesYes286
88B:B:I80 B:B:W82 66.395512.92NoYes089
89B:B:H54 B:B:I80 66.22636.63YesNo098
90B:B:D76 B:B:S74 65.56695.89YesNo099
91B:B:H62 B:B:Y105 12.00714.36NoYes066
92B:B:H62 B:B:R150 11.715810.16NoNo066
93B:B:L70 B:B:W63 68.13326.83NoYes057
94B:B:D186 B:B:G162 15.29156.71NoNo099
95B:B:G162 B:B:S161 15.0093.71NoNo099
96B:B:H142 B:B:S161 13.253415.34YesNo999
97B:B:H142 B:B:W169 10.36364.23YesYes998
98B:B:I232 B:B:T243 17.29143.04YesYes288
99B:B:I232 B:B:V200 15.37576.14YesYes286
100B:B:F234 B:B:V200 17.354810.49YesYes056
101B:B:F241 B:B:V200 15.45182.62YesYes266
102B:B:L210 B:B:V200 11.57382.98NoYes056
103B:B:H225 B:B:T243 10.65316.85YesYes298
104R:R:P798 R:R:Q830 36.58311.58YesNo099
105R:R:L634 R:R:Q830 35.86792.66NoNo099
106R:R:D638 R:R:L634 33.70214.07NoNo079
107R:R:D638 R:R:L593 33.21864.07NoYes078
108R:R:F569 R:R:L593 32.26053.65YesYes098
109R:R:F569 R:R:L572 16.2643.65YesNo099
110R:R:L572 R:R:W804 15.49572.28NoYes099
111R:R:F823 R:R:W804 13.28392YesYes3099
112R:R:F823 R:R:G807 11.92933.01YesNo099
113R:R:G807 R:R:T810 11.64973.64NoYes097
114R:R:F569 R:R:Y668 15.31732.06YesYes098
115R:R:F747 R:R:Y668 14.55392.06NoYes088
116R:R:F747 R:R:H665 13.48523.39NoYes089
117B:B:H54 B:B:S74 65.72928.37YesNo099
118B:B:L70 B:B:W82 67.96974.56NoYes059
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


PDB Summary
PDB 7WXU
Class B2
SubFamily Adhesion
Type Adhesion
SubType ADGRF1
Species Homo sapiens
Ligand -
Other Ligand(s) -
Protein Partners chim(NtGi1-Gs-CtGq)/Beta1/Gamma2
PDB Resolution 2.85
Date 2022-09-28
D.O.I. 10.1038/s41467-022-33173-4
Net Summary
Imin 1.82
Number of Linked Nodes 833
Number of Links 959
Number of Hubs 131
Number of Links mediated by Hubs 504
Number of Communities 34
Number of Nodes involved in Communities 193
Number of Links involved in Communities 251
Path Summary
Number Of Nodes in MetaPath 119
Number Of Links MetaPath 118
Number of Shortest Paths 778366
Length Of Smallest Path 3
Average Path Length 33.0459
Length of Longest Path 60
Minimum Path Strength 1.22
Average Path Strength 4.73196
Maximum Path Strength 17.615
Minimum Path Correlation 0.7
Average Path Correlation 0.974656
Maximum Path Correlation 1
Minimum % Of Corr. Nodes 2.43902
Average % Of Corr. Nodes 41.4587
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 40.0878
Maximum Path Hubs % 100
AnnotationTypeLinks
Gene OntologyMolecular Function
Gene OntologyBiological Process
Gene OntologyCellular Component
SCOP2Domain Identifier
SCOP2Family Identifier
Membrane Protein Annotations-• Orientations of Proteins in Membranes database (OPM)   • Protein Data Bank of Transmembrane Proteins (PDBTM)   • MemProtMD


Details about the values in these tables can be found in the corresponding documentation page .
PDBsumOpen PDBsum Page
ChainA
ProteinG Protein α Sub unit
UniProtP63092
Sequence
>7WXU_Chain_A
SAEDKAAVE RSKMIEKQL QKDKQVYRR TLRLLLLGA DNSGKSTIV 
KQMRIYVKT SGIFETKFQ VDKVNFHMF DVGAQRDER RKWIQCFND 
VTAIIFVVD SSDYNRLQE ALNDFKSIW NNRWLRTIS VILFLNKQD 
LLAEKVLAG KSKIEDYFP EFARYTTPE DATPEPGED PRVTRAKYF 
IRKEFVDIS TASGDGRHI CYPHFTCSV DTENARRIF NDCKDIILQ 
MNLREYNLV


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainB
ProteinG Protein β Sub unit
UniProtP62873
Sequence
>7WXU_Chain_B
ELDQLRQEA EQLKNQIRD ARKACADAT LSQITNNID PVGRIQMRT 
RRTLRGHLA KIYAMHWGT DSRLLVSAS QDGKLIIWD SYTTNKVHA 
IPLRSSWVM TCAYAPSGN YVACGGLDN ICSIYNLKT REGNVRVSR 
ELAGHTGYL SCCRFLDDN QIVTSSGDT TCALWDIET GQQTTTFTG 
HTGDVMSLS LAPDTRLFV SGACDASAK LWDVREGMC RQTFTGHES 
DINAICFFP NGNAFATGS DDATCRLFD LRADQELMT YSHDNIICG 
ITSVSFSKS GRLLLAGYD DFNCNVWDA LKADRAGVL AGHDNRVSC 
LGVTDDGMA VATGSWDSF LKIWN


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainG
ProteinG Protein γ Sub unit
UniProtP59768
Sequence
>7WXU_Chain_G
TASIAQARK LVEQLKMEA NIDRIKVSK AAADLMAYC EAHAKEDPL 
LTPVPASEN PFR


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainR
ProteinReceptor
UniProtQ5T601
Sequence
>7WXU_Chain_R
TSFSILMSP FVPSTIFPV VKWITYVGL GISIGSLIL CLIIEALFW 
KQIKKSQTS HTRRICMVN IALSLLIAD VWFIVGATV DTTVNPSGV 
CTAAVFFTH FFYLSLFFW MLMLGILLA YRIILVFHH MAQHLMMAV 
GFCLGYGCP LIISVITIA VTQPSNTYK RKDVCWLNW SNGSKPLLA 
FVVPALAIV AVNFVVVLL VLTKLWRPA TIIRVGKSL LILTPLLGL 
TWGFGIGTI VDSQNLAWH VIFALLNAF QGFFILCFG ILLDSKLRQ 
LLFNKLS


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  




This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
7WU3B2AdhesionAdhesionADGRF1Homo sapiens-K6GGs/&β;1/&γ;23.12022-04-2710.1038/s41586-022-04580-w
7WU4B2AdhesionAdhesionADGRF1Homo sapiens-K6GGi1/&β;1/&γ;23.42022-04-2710.1038/s41586-022-04580-w
7WU5B2AdhesionAdhesionADGRF1Homo sapiens-K6GGi1/&β;1/&γ;232022-04-2710.1038/s41586-022-04580-w
7WXUB2AdhesionAdhesionADGRF1Homo sapiens--chim(NtGi1-Gs-CtGq)/&β;1/&γ;22.852022-09-2810.1038/s41467-022-33173-4
7WXWB2AdhesionAdhesionADGRF1Homo sapiens--chim(NtGi1-Gs)/&β;1/&γ;22.842022-09-2810.1038/s41467-022-33173-4
7WY0B2AdhesionAdhesionADGRF1Homo sapiens--chim(NtGi1L-G13)/&β;1/&γ;22.832022-09-2810.1038/s41467-022-33173-4
7WZ7B2AdhesionAdhesionADGRF1Homo sapiens--chim(NtGi1-G12)/&β;1/&γ;22.832022-09-2810.1038/s41467-022-33173-4
7X2VB2AdhesionAdhesionADGRF1Homo sapiens--Gi1/&β;1/&γ;23.092022-09-2810.1038/s41467-022-33173-4
8G2YB2AdhesionAdhesionADGRF1Homo sapiens-LPCchim(Gs-CtGq)/&β;1/&γ;23.442023-05-1010.1038/s41467-023-38083-7




You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download 7WXU.zip



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