psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:F582	R:R:T567	3.89	Yes	No	0	1	9
2	R:R:S568	R:R:S570	3.26	Yes	No	0	9	9
3	R:R:I571	R:R:S568	4.64	No	Yes	0	7	9
4	R:R:S568	R:R:V577	9.7	Yes	No	0	9	3
5	R:R:F569	R:R:L572	7.31	Yes	No	1	9	9
6	R:R:F569	R:R:T589	5.19	Yes	No	0	9	9
7	R:R:F569	R:R:F641	3.22	Yes	Yes	1	9	9
8	R:R:F569	R:R:F823	5.36	Yes	Yes	1	9	9
9	R:R:F569	R:R:N827	3.62	Yes	Yes	1	9	9
10	R:R:H820	R:R:S570	8.37	No	No	0	8	9
11	R:R:L572	R:R:Y668	7.03	No	Yes	1	9	8
12	R:R:F747	R:R:L572	4.87	Yes	No	1	8	9
13	R:R:G807	R:R:M573	5.24	No	No	0	9	9
14	R:R:P575	R:R:S574	3.56	Yes	No	0	6	9
15	R:R:S574	R:R:T810	4.8	No	Yes	0	9	7
16	R:R:P575	R:R:W737	8.11	Yes	No	0	6	6
17	R:R:P578	R:R:V577	3.53	Yes	No	0	4	3
18	R:R:I581	R:R:P578	5.08	Yes	Yes	0	4	4
19	R:R:H820	R:R:P578	4.58	No	Yes	0	8	4
20	R:R:I581	R:R:V585	3.07	Yes	No	0	4	8
21	R:R:I581	R:R:L817	9.99	Yes	No	0	4	2
22	R:R:I581	R:R:V821	3.07	Yes	No	0	4	7
23	R:R:F582	R:R:P583	4.33	Yes	No	0	1	1
24	R:R:F582	R:R:K586	6.2	Yes	No	0	1	3
25	R:R:K586	R:R:Y590	11.94	No	No	0	3	5
26	R:R:I595	R:R:V591	3.07	No	No	0	7	7
27	R:R:F829	R:R:G592	4.52	Yes	No	0	7	9
28	R:R:I642	R:R:L593	4.28	No	No	0	8	8
29	R:R:F829	R:R:I595	10.05	Yes	No	0	7	7
30	R:R:F832	R:R:I595	3.77	Yes	No	0	5	7
31	R:R:I597	R:R:S596	3.1	Yes	No	0	7	9
32	R:R:D638	R:R:S596	4.42	No	No	0	7	9
33	R:R:G831	R:R:S599	3.71	No	No	0	9	8
34	R:R:L835	R:R:S599	7.51	No	No	0	8	8
35	R:R:L600	R:R:L634	9.69	No	No	0	9	9
36	R:R:L600	R:R:L635	5.54	No	No	0	9	8
37	R:R:C603	R:R:I839	3.27	No	No	0	7	7
38	R:R:F610	R:R:I606	3.77	Yes	No	0	8	8
39	R:R:I606	R:R:L849	4.28	No	No	0	8	7
40	R:R:E607	R:R:W611	4.36	No	No	0	9	9
41	R:R:E607	R:R:R624	10.47	No	No	0	9	9
42	R:R:F610	R:R:L609	7.31	Yes	No	0	8	4
43	R:R:F610	R:R:I614	3.77	Yes	No	0	8	7
44	R:R:F610	R:R:L848	12.18	Yes	No	0	8	7
45	R:R:K612	R:R:W611	10.44	No	No	0	7	9
46	R:R:K615	R:R:W611	11.6	No	No	0	8	9
47	R:R:I614	R:R:Q613	5.49	No	No	0	7	5
48	R:R:K615	R:R:S620	3.06	No	No	0	8	8
49	R:R:H621	R:R:K615	28.82	No	No	0	6	8
50	R:R:Q618	R:R:S617	2.89	No	No	0	7	8
51	R:R:S617	R:R:T619	3.2	No	No	0	8	8
52	R:R:H692	R:R:Q618	7.42	No	No	0	6	7
53	R:R:Q618	R:R:Q695	3.84	No	No	0	7	6
54	R:R:R685	R:R:T619	14.23	No	No	0	8	8
55	R:R:R623	R:R:S620	3.95	No	No	0	9	8
56	R:R:L681	R:R:T622	5.9	No	Yes	2	7	7
57	R:R:R685	R:R:T622	3.88	No	Yes	2	8	7
58	R:R:M698	R:R:T622	4.52	No	Yes	0	8	7
59	R:R:M699	R:R:T622	4.52	Yes	Yes	0	7	7
60	R:R:R623	R:R:R624	8.53	No	No	0	9	9
61	R:R:M627	R:R:R623	7.44	No	No	0	7	9
62	R:R:I625	R:R:M699	4.37	No	Yes	0	7	7
63	R:R:C626	W:W:?1	3.92	No	Yes	0	7	0
64	R:R:N629	R:R:W674	22.6	No	Yes	2	9	9
65	R:R:F703	R:R:N629	8.46	No	No	2	8	9
66	R:R:N629	R:R:Y707	5.81	No	Yes	2	9	9
67	R:R:I630	R:R:W674	3.52	No	Yes	0	8	9
68	R:R:I636	R:R:L632	5.71	No	No	0	7	5
69	R:R:S633	R:R:S670	3.26	No	No	2	8	8
70	R:R:L671	R:R:S633	3	No	No	0	7	8
71	R:R:S633	R:R:Y707	3.82	No	Yes	2	8	9
72	R:R:D638	R:R:L634	5.43	No	No	0	7	9
73	R:R:L634	R:R:L671	4.15	No	No	0	9	7
74	R:R:F667	R:R:I636	15.07	Yes	No	0	8	7
75	R:R:A637	R:R:Y668	4	No	Yes	0	9	8
76	R:R:V643	R:R:W640	3.68	No	Yes	0	8	6
77	R:R:F663	R:R:W640	15.03	No	Yes	1	8	6
78	R:R:T664	R:R:W640	3.64	Yes	Yes	1	7	6
79	R:R:F667	R:R:W640	3.01	Yes	Yes	1	8	6
80	R:R:F641	R:R:T664	3.89	Yes	Yes	1	9	7
81	R:R:F641	R:R:Y668	5.16	Yes	Yes	1	9	8
82	R:R:V647	R:R:V656	4.81	Yes	No	0	5	5
83	R:R:D648	R:R:V651	5.84	No	No	0	5	1
84	R:R:N652	R:R:V651	4.43	Yes	No	0	4	1
85	R:R:G655	R:R:N652	5.09	No	Yes	0	3	4
86	R:R:N652	R:R:V656	7.39	Yes	No	0	4	5
87	R:R:S654	R:R:T658	3.2	No	No	0	4	6
88	R:R:C657	R:R:C733	7.28	No	No	0	9	9
89	R:R:V661	R:R:Y727	3.79	No	Yes	0	8	9
90	R:R:V661	R:R:W734	4.9	No	Yes	0	8	8
91	R:R:F662	R:R:S714	3.96	No	No	0	8	9
92	R:R:F662	R:R:I718	8.79	No	No	0	8	7
93	R:R:F663	R:R:F667	4.29	No	Yes	1	8	8
94	R:R:T664	R:R:Y668	8.74	Yes	Yes	1	7	8
95	R:R:T664	R:R:W734	4.85	Yes	Yes	1	7	8
96	R:R:H665	R:R:S714	4.18	No	No	0	9	9
97	R:R:A746	R:R:H665	2.93	No	No	0	9	9
98	R:R:F747	R:R:H665	9.05	Yes	No	0	8	9
99	R:R:F666	R:R:F667	9.65	No	Yes	0	7	8
100	R:R:F666	R:R:P710	2.89	No	Yes	0	7	9
101	R:R:F666	R:R:S714	5.28	No	No	0	7	9
102	R:R:W734	R:R:Y668	4.82	Yes	Yes	1	8	8
103	R:R:F747	R:R:Y668	7.22	Yes	Yes	1	8	8
104	R:R:F673	R:R:L669	9.74	Yes	No	0	8	9
105	R:R:S670	R:R:Y707	3.82	No	Yes	2	8	9
106	R:R:P710	R:R:S670	3.56	Yes	No	0	9	8
107	R:R:L671	R:R:M675	5.65	No	No	0	7	9
108	R:R:A751	R:R:F672	8.32	No	No	0	9	9
109	R:R:F672	R:R:W804	17.04	No	Yes	0	9	9
110	R:R:C709	R:R:F673	5.59	No	Yes	0	8	8
111	R:R:F673	R:R:P710	7.22	Yes	Yes	0	8	9
112	R:R:F673	R:R:I754	5.02	Yes	No	0	8	9
113	R:R:M677	R:R:W674	4.65	No	Yes	2	6	9
114	R:R:F703	R:R:W674	8.02	No	Yes	2	8	9
115	R:R:W674	R:R:Y707	10.61	Yes	Yes	2	9	9
116	R:R:W674	W:W:?1	6.56	Yes	Yes	2	9	0
117	R:R:G801	R:R:M675	3.49	No	No	0	9	9
118	R:R:I754	R:R:L676	11.42	No	No	0	9	7
119	R:R:L676	R:R:V757	2.98	No	No	0	7	7
120	R:R:L705	R:R:M677	4.24	No	No	0	6	6
121	R:R:M677	W:W:?1	4.65	No	Yes	2	6	0
122	R:R:L678	R:R:L800	5.54	No	Yes	4	8	9
123	R:R:I680	W:W:?1	5.87	No	Yes	0	8	0
124	R:R:L681	R:R:R685	12.15	No	No	2	7	8
125	R:R:L681	W:W:?1	10.25	No	Yes	2	7	0
126	R:R:A683	R:R:V761	3.39	No	No	0	6	8
127	R:R:L688	R:R:Y684	7.03	No	No	2	6	8
128	R:R:H691	R:R:Y684	8.71	No	No	0	7	8
129	R:R:Y684	W:W:?1	27.96	No	Yes	2	8	0
130	R:R:I686	R:R:K768	5.82	No	No	0	7	8
131	R:R:I687	R:R:L688	7.14	No	No	0	6	6
132	R:R:L688	W:W:?1	4.55	No	Yes	2	6	0
133	R:R:F690	R:R:V689	11.8	No	No	0	8	9
134	R:R:H696	R:R:Q695	7.42	No	No	0	5	6
135	R:R:M699	R:R:Q695	6.8	Yes	No	0	7	6
136	R:R:L697	R:R:V701	2.98	No	No	0	3	6
137	R:R:M698	W:W:?1	4.65	No	Yes	0	8	0
138	R:R:M699	W:W:?1	5.81	Yes	Yes	0	7	0
139	R:R:G702	W:W:?1	4.22	No	Yes	0	7	0
140	R:R:F703	R:R:Y707	3.09	No	Yes	2	8	9
141	R:R:L711	R:R:V715	2.98	No	No	0	7	6
142	R:R:I713	R:R:I716	2.94	No	No	0	9	7
143	R:R:A746	R:R:I713	3.25	No	No	0	9	9
144	R:R:I718	R:R:Y727	8.46	No	Yes	0	7	9
145	R:R:T721	R:R:T726	3.14	Yes	Yes	3	9	4
146	R:R:T721	R:R:Y727	6.24	Yes	Yes	0	9	9
147	R:R:S741	R:R:T721	4.8	Yes	Yes	3	8	9
148	R:R:P743	R:R:T721	8.74	Yes	Yes	3	8	9
149	R:R:S724	R:R:T726	9.59	No	Yes	0	3	4
150	R:R:K728	R:R:N725	5.6	No	No	0	5	4
151	R:R:N736	R:R:T726	2.92	Yes	Yes	3	8	4
152	R:R:S741	R:R:T726	7.99	Yes	Yes	3	8	4
153	R:R:L735	R:R:Y727	9.38	Yes	Yes	0	9	9
154	R:R:N736	R:R:R729	10.85	Yes	No	0	8	5
155	R:R:G740	R:R:R729	4.5	No	No	0	4	5
156	R:R:D731	R:R:V732	5.84	No	No	0	3	4
157	R:R:L735	R:R:W734	4.56	Yes	Yes	0	9	8
158	R:R:F747	R:R:W734	5.01	Yes	Yes	1	8	8
159	R:R:L735	R:R:P743	3.28	Yes	Yes	0	9	8
160	R:R:L735	R:R:L744	5.54	Yes	No	0	9	8
161	R:R:N736	R:R:S741	4.47	Yes	Yes	3	8	8
162	R:R:N736	R:R:P743	4.89	Yes	Yes	3	8	8
163	R:R:L744	R:R:W737	4.56	No	No	0	8	6
164	R:R:P743	R:R:S741	7.13	Yes	Yes	3	8	8
165	R:R:K742	R:R:L745	5.64	No	No	0	7	8
166	R:R:L744	R:R:V748	2.98	No	No	0	8	7
167	R:R:L745	R:R:V749	2.98	No	No	0	8	7
168	R:R:I811	R:R:V748	4.61	No	No	0	5	7
169	R:R:P750	R:R:V749	7.07	No	No	0	9	7
170	R:R:I808	R:R:L752	7.14	No	No	0	7	8
171	R:R:I754	R:R:N758	4.25	No	No	0	9	9
172	R:R:L800	R:R:N758	15.1	Yes	No	0	9	9
173	R:R:F759	R:R:L763	4.87	No	No	0	4	4
174	R:R:L796	R:R:V762	4.47	No	No	0	9	8
175	R:R:L802	R:R:V762	2.98	No	No	0	7	8
176	R:R:L764	R:R:T767	2.95	No	No	0	7	4
177	R:R:K768	R:R:T767	3	No	No	0	8	4
178	R:R:L769	R:R:V789	5.96	No	No	0	7	8
179	R:R:L769	R:R:S792	3	No	No	0	7	8
180	R:R:T785	R:R:W770	3.64	No	Yes	0	7	6
181	R:R:I786	R:R:W770	3.52	No	Yes	0	6	6
182	R:R:V789	R:R:W770	7.36	No	Yes	0	8	6
183	R:R:P772	R:R:R771	7.21	No	No	0	7	8
184	R:R:R777	R:R:T773	6.47	No	No	0	5	6
185	R:R:R777	R:R:R780	5.33	No	No	0	5	3
186	R:R:L778	R:R:S779	3	No	No	0	5	4
187	R:R:A784	R:R:D781	4.63	No	No	0	6	6
188	R:R:D781	R:R:T785	7.23	No	No	0	6	7
189	R:R:R788	R:R:T785	6.47	No	No	0	7	7
190	R:R:L793	R:R:T797	2.95	No	No	0	7	9
191	R:R:I795	R:R:L841	7.14	No	No	0	7	5
192	R:R:L796	R:R:L800	6.92	No	Yes	0	9	9
193	R:R:P798	R:R:T797	3.5	No	No	0	9	9
194	R:R:L802	R:R:T797	7.37	No	No	0	7	9
195	R:R:F833	R:R:P798	2.89	Yes	No	5	7	9
196	R:R:F837	R:R:P798	5.78	Yes	No	5	8	9
197	R:R:I834	R:R:L799	4.28	No	No	0	9	6
198	R:R:L826	R:R:T803	4.42	No	No	0	6	9
199	R:R:N827	R:R:T803	8.77	Yes	No	0	9	9
200	R:R:F823	R:R:W804	3.01	Yes	Yes	1	9	9
201	R:R:N827	R:R:W804	11.3	Yes	Yes	1	9	9
202	R:R:Q830	R:R:W804	14.24	No	Yes	1	9	9
203	R:R:F806	R:R:W819	3.01	No	No	6	8	6
204	R:R:F806	R:R:I822	3.77	No	No	6	8	5
205	R:R:F806	R:R:L826	3.65	No	No	0	8	6
206	R:R:G807	R:R:T810	3.64	No	Yes	0	9	7
207	R:R:F823	R:R:G807	3.01	Yes	No	0	9	9
208	R:R:I808	R:R:I811	5.89	No	No	0	7	5
209	R:R:G809	R:R:V812	3.68	No	No	0	7	6
210	R:R:I811	R:R:T810	3.04	No	Yes	0	5	7
211	R:R:H820	R:R:T810	5.48	No	Yes	0	8	7
212	R:R:D813	R:R:V812	4.38	No	No	0	4	6
213	R:R:D813	R:R:Q815	7.83	No	No	0	4	3
214	R:R:D813	R:R:N816	12.12	No	No	0	4	5
215	R:R:N816	R:R:W819	11.3	No	No	0	5	6
216	R:R:I822	R:R:W819	3.52	No	No	6	5	6
217	R:R:F823	R:R:N827	12.08	Yes	Yes	1	9	9
218	R:R:N827	R:R:Q830	3.96	Yes	No	1	9	9
219	R:R:F829	R:R:F833	4.29	Yes	Yes	0	7	7
220	R:R:G831	R:R:I834	3.53	No	No	0	9	9
221	R:R:F832	R:R:F833	4.29	Yes	Yes	0	5	7
222	R:R:C836	R:R:F832	8.38	No	Yes	0	7	5
223	R:R:F833	R:R:F837	4.29	Yes	Yes	5	7	8
224	R:R:I839	R:R:L835	4.28	No	No	0	7	8
225	R:R:F837	R:R:L841	6.09	Yes	No	0	8	5
226	R:R:D842	R:R:L845	4.07	No	No	0	9	8
227	R:R:F850	R:R:R846	4.28	No	No	0	3	7
228	R:R:E607	R:R:V628	2.85	No	No	0	9	7
229	R:R:I614	R:R:L845	2.85	No	No	0	7	8
230	R:R:I839	R:R:L845	2.85	No	No	0	7	8
231	R:R:L799	R:R:M627	2.83	No	No	0	6	7
232	R:R:K852	R:R:N851	2.8	No	No	0	4	4
233	R:R:L602	R:R:L835	2.77	No	No	0	6	8
234	R:R:L678	R:R:L682	2.77	No	No	0	8	9
235	R:R:D782	R:R:K783	2.77	No	No	0	7	6
236	R:R:F576	R:R:S814	2.64	No	No	0	3	5
237	R:R:F832	R:R:S599	2.64	Yes	No	0	5	8
238	R:R:R846	R:R:S843	2.64	No	No	0	7	5
239	R:R:F672	R:R:V755	2.62	No	No	0	9	8
240	R:R:A660	R:R:W640	2.59	No	Yes	0	7	6
241	R:R:T717	R:R:Y727	2.5	No	Yes	0	9	9
242	R:R:K768	R:R:R771	2.48	No	No	0	8	8
243	R:R:F641	R:R:L593	2.44	Yes	No	0	9	8
244	R:R:F829	R:R:L825	2.44	Yes	No	0	7	5
245	R:R:L766	R:R:W770	2.28	No	Yes	0	7	6
246	R:R:G706	R:R:P710	2.03	No	Yes	0	9	9
247	R:R:G708	R:R:P710	2.03	No	Yes	0	6	9
248	R:R:A828	R:R:G592	1.95	No	No	0	8	9
249	R:R:A660	R:R:G644	1.95	No	No	0	7	6
250	R:R:G644	R:R:V647	1.84	No	Yes	0	6	5
251	R:R:G679	R:R:V761	1.84	No	No	0	9	8
252	R:R:G702	R:R:V701	1.84	No	No	0	7	6
253	R:R:G805	R:R:V755	1.84	No	No	0	6	8
254	R:R:P575	R:R:S738	1.78	Yes	No	0	6	2
255	R:R:P575	R:R:S814	1.78	Yes	No	0	6	5
256	R:R:G594	R:R:I597	1.76	No	Yes	0	5	7
257	R:R:G598	R:R:I601	1.76	No	No	0	3	5
258	R:R:P578	R:R:T580	1.75	Yes	No	0	4	3
259	R:R:C657	R:R:V647	1.71	No	Yes	0	9	5
260	R:R:G679	R:R:L678	1.71	No	No	4	9	8
261	R:R:G679	R:R:L800	1.71	No	Yes	4	9	9
262	R:R:G708	R:R:L711	1.71	No	No	0	6	7
263	R:R:G790	R:R:L793	1.71	No	No	0	5	7
264	R:R:G838	R:R:L799	1.71	No	No	0	8	6
265	R:R:A824	R:R:V585	1.7	No	No	0	8	8
266	R:R:C733	R:R:T649	1.69	No	No	0	9	3
267	R:R:I713	R:R:P750	1.69	No	No	0	9	9
268	R:R:A645	R:R:T567	1.68	No	No	0	7	9
269	R:R:K728	R:R:P653	1.67	No	No	0	5	4
270	R:R:N652	R:R:P653	1.63	Yes	No	0	4	4
271	R:R:S792	R:R:V765	1.62	No	No	0	8	9
272	R:R:T646	R:R:V647	1.59	No	Yes	0	5	5
273	R:R:T721	R:R:V720	1.59	Yes	No	0	9	5
274	R:R:A631	R:R:L600	1.58	No	No	0	8	9
275	R:R:A631	R:R:L604	1.58	No	No	0	8	8
276	R:R:A694	R:R:L697	1.58	No	No	0	8	3
277	R:R:P723	R:R:Q722	1.58	No	No	0	8	7
278	R:R:A818	R:R:L817	1.58	No	No	0	6	2
279	R:R:I571	R:R:V732	1.54	No	No	0	7	4
280	R:R:I581	R:R:V584	1.54	Yes	No	0	4	3
281	R:R:I597	R:R:V639	1.54	Yes	No	0	7	6
282	R:R:K791	R:R:S843	1.53	No	No	0	8	5
283	R:R:L766	R:R:V762	1.49	No	No	0	7	8
284	R:R:L796	R:R:V765	1.49	No	No	0	9	9
285	R:R:I597	R:R:I601	1.47	Yes	No	0	7	5
286	R:R:I712	R:R:I716	1.47	No	No	0	5	7
287	R:R:I786	R:R:K783	1.45	No	No	0	6	6
288	R:R:I795	R:R:K791	1.45	No	No	0	7	8
289	R:R:Q847	R:R:S843	1.44	No	No	0	6	5
290	R:R:I588	R:R:L825	1.43	No	No	0	9	5
291	R:R:D731	R:R:K730	1.38	No	No	0	3	2
292	R:R:I718	R:R:Q722	1.37	No	No	0	7	7
293	R:R:F582	R:R:S568	1.32	Yes	Yes	0	1	9
294	R:R:H691	R:R:M693	1.31	No	No	0	7	5
295	R:R:F759	R:R:L802	1.22	No	No	0	4	7
296	R:R:F837	R:R:L794	1.22	Yes	No	0	8	6

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	R:R:S568	4.73	4	0	9
2	R:R:F569	4.94	5	1	9
3	R:R:P575	3.8075	4	0	6
4	R:R:P578	3.735	4	0	4
5	R:R:I581	4.55	5	0	4
6	R:R:F582	3.935	4	0	1
7	R:R:I597	1.9675	4	0	7
8	R:R:F610	6.7575	4	0	8
9	R:R:T622	4.705	4	2	7
10	R:R:W640	5.59	5	1	6
11	R:R:F641	3.6775	4	1	9
12	R:R:V647	2.4875	4	0	5
13	R:R:N652	4.635	4	0	4
14	R:R:T664	5.28	4	1	7
15	R:R:F667	8.005	4	1	8
16	R:R:Y668	6.16167	6	1	8
17	R:R:F673	6.8925	4	0	8
18	R:R:W674	9.32667	6	2	9
19	R:R:M699	5.375	4	0	7
20	R:R:Y707	5.43	5	2	9
21	R:R:P710	3.546	5	0	9
22	R:R:T721	4.902	5	3	9
23	R:R:T726	5.91	4	3	4
24	R:R:Y727	6.074	5	0	9
25	R:R:W734	4.828	5	1	8
26	R:R:L735	5.69	4	0	9
27	R:R:N736	5.7825	4	3	8
28	R:R:S741	6.0975	4	3	8
29	R:R:P743	6.01	4	3	8
30	R:R:F747	6.5375	4	1	8
31	R:R:W770	4.2	4	0	6
32	R:R:L800	7.3175	4	4	9
33	R:R:W804	11.3975	4	1	9
34	R:R:T810	4.24	4	0	7
35	R:R:F823	5.865	4	1	9
36	R:R:N827	7.946	5	1	9
37	R:R:F829	5.325	4	0	7
38	R:R:F832	4.77	4	0	5
39	R:R:F833	3.94	4	5	7
40	R:R:F837	4.345	4	5	8
41	W:W:?1	7.844	10	2	0

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:S568	R:R:S570	13.7506	3.26	Yes	No	0	9	9
2	R:R:F569	R:R:F823	37.6493	5.36	Yes	Yes	1	9	9
3	R:R:F823	R:R:G807	30.8871	3.01	Yes	No	0	9	9
4	R:R:G807	R:R:T810	28.9696	3.64	No	Yes	0	9	7
5	R:R:H820	R:R:T810	28.6224	5.48	No	Yes	0	8	7
6	R:R:H820	R:R:S570	14.9896	8.37	No	No	0	8	9
7	R:R:F569	R:R:L572	32.0242	7.31	Yes	No	1	9	9
8	R:R:F569	R:R:F641	33.8493	3.22	Yes	Yes	1	9	9
9	R:R:F747	R:R:L572	29.3295	4.87	Yes	No	1	8	9
10	R:R:F747	R:R:H665	38.2991	9.05	Yes	No	0	8	9
11	R:R:H665	R:R:S714	39.535	4.18	No	No	0	9	9
12	R:R:F666	R:R:S714	56.8785	5.28	No	No	0	7	9
13	R:R:F666	R:R:P710	100	2.89	No	Yes	0	7	9
14	R:R:F673	R:R:P710	76.2924	7.22	Yes	Yes	0	8	9
15	R:R:F673	R:R:I754	74.4577	5.02	Yes	No	0	8	9
16	R:R:I754	R:R:N758	72.5657	4.25	No	No	0	9	9
17	R:R:L800	R:R:N758	71.9223	15.1	Yes	No	0	9	9
18	R:R:L796	R:R:L800	67.928	6.92	No	Yes	0	9	9
19	R:R:L796	R:R:V762	64.1726	4.47	No	No	0	9	8
20	R:R:L802	R:R:V762	56.2637	2.98	No	No	0	7	8
21	R:R:L802	R:R:T797	53.8748	7.37	No	No	0	7	9
22	R:R:P798	R:R:T797	51.4286	3.5	No	No	0	9	9
23	R:R:F833	R:R:P798	41.6977	2.89	Yes	No	5	7	9
24	R:R:F641	R:R:T664	32.1484	3.89	Yes	Yes	1	9	7
25	R:R:T664	R:R:W640	42.768	3.64	Yes	Yes	1	7	6
26	R:R:F667	R:R:W640	44.4179	3.01	Yes	Yes	1	8	6
27	R:R:F666	R:R:F667	45.3798	9.65	No	Yes	0	7	8
28	R:R:F832	R:R:F833	35.3368	4.29	Yes	Yes	0	5	7
29	R:R:P710	R:R:S670	50.473	3.56	Yes	No	0	9	8
30	R:R:S633	R:R:S670	15.9484	3.26	No	No	2	8	8
31	R:R:L671	R:R:S633	16.6237	3	No	No	0	7	8
32	R:R:L634	R:R:L671	13.413	4.15	No	No	0	9	7
33	R:R:F832	R:R:S599	32.0624	2.64	Yes	No	0	5	8
34	R:R:G831	R:R:S599	17.834	3.71	No	No	0	9	8
35	R:R:L835	R:R:S599	14.5724	7.51	No	No	0	8	8
36	R:R:I839	R:R:L835	12.3937	4.28	No	No	0	7	8
37	R:R:I839	R:R:L845	10.1895	2.85	No	No	0	7	8
38	R:R:M627	R:R:R623	12.4351	7.44	No	No	0	7	9
39	R:R:L799	R:R:M627	13.5276	2.83	No	No	0	6	7
40	R:R:I834	R:R:L799	15.6936	4.28	No	No	0	9	6
41	R:R:G831	R:R:I834	16.767	3.53	No	No	0	9	9
42	R:R:S670	R:R:Y707	33.6869	3.82	No	Yes	2	8	9
43	R:R:W674	R:R:Y707	32.3746	10.61	Yes	Yes	2	9	9
44	R:R:W674	W:W:?1	28.4918	6.56	Yes	Yes	2	9	0
45	R:R:A660	R:R:W640	13.757	2.59	No	Yes	0	7	6
46	R:R:A660	R:R:G644	12.8842	1.95	No	No	0	7	6
47	R:R:G644	R:R:V647	12.0051	1.84	No	Yes	0	6	5
48	R:R:L735	R:R:L744	19.9331	5.54	Yes	No	0	9	8
49	R:R:L735	R:R:Y727	12.7759	9.38	Yes	Yes	0	9	9
50	R:R:L735	R:R:W734	26.896	4.56	Yes	Yes	0	9	8
51	R:R:I718	R:R:Y727	19.1846	8.46	No	Yes	0	7	9
52	R:R:F662	R:R:I718	18.0666	8.79	No	No	0	8	7
53	R:R:F672	R:R:W804	12.6485	17.04	No	Yes	0	9	9
54	R:R:T721	R:R:Y727	11.5401	6.24	Yes	Yes	0	9	9
55	R:R:L735	R:R:P743	13.1231	3.28	Yes	Yes	0	9	8
56	R:R:L766	R:R:V762	11.2183	1.49	No	No	0	7	8
57	R:R:L766	R:R:W770	10.1354	2.28	No	Yes	0	7	6
58	R:R:N827	R:R:T803	16.56	8.77	Yes	No	0	9	9
59	R:R:L826	R:R:T803	14.9323	4.42	No	No	0	6	9
60	R:R:F806	R:R:L826	13.2983	3.65	No	No	0	8	6
61	R:R:H820	R:R:P578	12.5115	4.58	No	Yes	0	8	4
62	R:R:F747	R:R:W734	13.053	5.01	Yes	Yes	1	8	8
63	R:R:T664	R:R:W734	15.0756	4.85	Yes	Yes	1	7	8
64	R:R:F662	R:R:S714	18.538	3.96	No	No	0	8	9
65	R:R:F569	R:R:N827	25.5901	3.62	Yes	Yes	1	9	9

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:L681	R:R:T622	5.9	2	No	Yes	7	7	1	2
R:R:R685	R:R:T622	3.88	2	No	Yes	8	7	2	2
R:R:M698	R:R:T622	4.52	0	No	Yes	8	7	1	2
R:R:M699	R:R:T622	4.52	0	Yes	Yes	7	7	1	2
R:R:I625	R:R:M699	4.37	0	No	Yes	7	7	2	1
R:R:C626	W:W:?1	3.92	0	No	Yes	7	0	1	0
R:R:N629	R:R:W674	22.6	2	No	Yes	9	9	2	1
R:R:F703	R:R:N629	8.46	2	No	No	8	9	2	2
R:R:N629	R:R:Y707	5.81	2	No	Yes	9	9	2	2
R:R:I630	R:R:W674	3.52	0	No	Yes	8	9	2	1
R:R:M677	R:R:W674	4.65	2	No	Yes	6	9	1	1
R:R:F703	R:R:W674	8.02	2	No	Yes	8	9	2	1
R:R:W674	R:R:Y707	10.61	2	Yes	Yes	9	9	1	2
R:R:W674	W:W:?1	6.56	2	Yes	Yes	9	0	1	0
R:R:L705	R:R:M677	4.24	0	No	No	6	6	2	1
R:R:M677	W:W:?1	4.65	2	No	Yes	6	0	1	0
R:R:I680	W:W:?1	5.87	0	No	Yes	8	0	1	0
R:R:L681	R:R:R685	12.15	2	No	No	7	8	1	2
R:R:L681	W:W:?1	10.25	2	No	Yes	7	0	1	0
R:R:L688	R:R:Y684	7.03	2	No	No	6	8	1	1
R:R:H691	R:R:Y684	8.71	0	No	No	7	8	2	1
R:R:Y684	W:W:?1	27.96	2	No	Yes	8	0	1	0
R:R:I687	R:R:L688	7.14	0	No	No	6	6	2	1
R:R:L688	W:W:?1	4.55	2	No	Yes	6	0	1	0
R:R:M699	R:R:Q695	6.8	0	Yes	No	7	6	1	2
R:R:M698	W:W:?1	4.65	0	No	Yes	8	0	1	0
R:R:M699	W:W:?1	5.81	0	Yes	Yes	7	0	1	0
R:R:G702	W:W:?1	4.22	0	No	Yes	7	0	1	0
R:R:F703	R:R:Y707	3.09	2	No	Yes	8	9	2	2
R:R:G702	R:R:V701	1.84	0	No	No	7	6	1	2

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	7WU4_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	2.89
Number of Linked Nodes	267
Number of Links	296
Number of Hubs	41
Number of Links mediated by Hubs	146
Number of Communities	6
Number of Nodes involved in Communities	41
Number of Links involved in Communities	58

Path Summary
Number Of Nodes in MetaPath	66
Number Of Links MetaPath	65
Number of Shortest Paths	53184
Length Of Smallest Path	3
Average Path Length	16.259
Length of Longest Path	38
Minimum Path Strength	1.47333
Average Path Strength	5.29236
Maximum Path Strength	20.21
Minimum Path Correlation	0.7
Average Path Correlation	0.944823
Maximum Path Correlation	1
Minimum % Of Corr. Nodes	4
Average % Of Corr. Nodes	54.3799
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	42.577
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function	• D2 dopamine receptor binding • protein binding • binding • signaling receptor binding • G protein-coupled receptor binding • dopamine receptor binding • enzyme regulator activity • adenylate cyclase inhibitor activity • cyclase regulator activity • molecular function inhibitor activity • cyclase inhibitor activity • molecular function regulator activity • enzyme inhibitor activity • adenylate cyclase regulator activity • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • cation binding • magnesium ion binding • metal ion binding • GDP binding • G protein-coupled serotonin receptor binding • protein-containing complex binding • G-protein beta/gamma-subunit complex binding • pyrophosphatase activity • GTPase activity • G protein activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • adenylate cyclase-inhibiting serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • cell communication • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular process • signal transduction
Gene Ontology	Biological Process	• cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • adenylate cyclase-inhibiting serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • cell communication • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular process • signal transduction • response to hormone • response to chemical • response to endogenous stimulus • response to peptide hormone • response to oxygen-containing compound • response to nitrogen compound • cell division • leukocyte migration • immune system process • mononuclear cell migration • lymphocyte migration • cell migration • T cell migration • cell motility • regulation of steroid biosynthetic process • regulation of cholesterol biosynthetic process • regulation of cholesterol metabolic process • steroid metabolic process • regulation of lipid metabolic process • sterol metabolic process • positive regulation of biological process • cholesterol metabolic process • lipid biosynthetic process • alcohol metabolic process • regulation of primary metabolic process • positive regulation of metabolic process • regulation of small molecule metabolic process • positive regulation of biosynthetic process • positive regulation of lipid metabolic process • small molecule metabolic process • steroid biosynthetic process • positive regulation of cellular process • regulation of biosynthetic process • secondary alcohol biosynthetic process • regulation of alcohol biosynthetic process • small molecule biosynthetic process • regulation of steroid metabolic process • cholesterol biosynthetic process • positive regulation of cholesterol biosynthetic process • primary metabolic process • secondary alcohol metabolic process • positive regulation of steroid biosynthetic process • biosynthetic process • sterol biosynthetic process • positive regulation of lipid biosynthetic process • regulation of sterol biosynthetic process • alcohol biosynthetic process • positive regulation of cholesterol metabolic process • positive regulation of steroid metabolic process • metabolic process • regulation of lipid biosynthetic process • positive regulation of small molecule metabolic process • regulation of metabolic process • positive regulation of alcohol biosynthetic process • positive regulation of sterol biosynthetic process • lipid metabolic process • negative regulation of protein transport • regulation of localization • establishment of protein localization • nitrogen compound transport • negative regulation of biological process • negative regulation of transport • localization • negative regulation of secretion • negative regulation of hormone secretion • negative regulation of secretion by cell • intracellular protein localization • regulation of biological quality • regulation of peptide hormone secretion • negative regulation of peptide hormone secretion • regulation of hormone levels • establishment of protein localization to extracellular region • negative regulation of establishment of protein localization • protein secretion • establishment of localization • regulation of protein secretion • regulation of secretion • negative regulation of protein secretion • regulation of hormone secretion • regulation of protein localization • regulation of peptide secretion • transport • negative regulation of signaling • hormone secretion • negative regulation of cell communication • protein localization to extracellular region • negative regulation of peptide secretion • peptide secretion • regulation of secretion by cell • secretion by cell • amide transport • signal release • negative regulation of cellular process • negative regulation of protein localization • regulation of signaling • regulation of transport • secretion • regulation of peptide transport • regulation of establishment of protein localization • export from cell • cell-cell signaling • regulation of protein transport • peptide transport • negative regulation of insulin secretion • protein transport • regulation of insulin secretion • peptide hormone secretion • macromolecule localization • hormone transport • regulation of cell communication • insulin secretion • regulation of cytoskeleton organization • regulation of cellular component organization • microtubule cytoskeleton organization • regulation of mitotic spindle organization • mitotic cell cycle • cellular component organization • cell cycle • cellular component organization or biogenesis • regulation of cell cycle • microtubule cytoskeleton organization involved in mitosis • spindle organization • cell cycle process • regulation of cell cycle process • regulation of microtubule-based process • regulation of spindle organization • regulation of organelle organization • mitotic spindle organization • organelle organization • mitotic cell cycle process • microtubule-based process • cytoskeleton organization • regulation of microtubule cytoskeleton organization • positive regulation of protein localization to cell periphery • protein localization to cell periphery • positive regulation of protein localization to cell cortex • regulation of protein localization to cell periphery • regulation of protein localization to cell cortex • positive regulation of protein localization • protein localization to cell cortex • response to ketone • response to prostaglandin • response to lipid • response to alcohol • response to prostaglandin E • cellular response to forskolin • cellular response to oxygen-containing compound • cellular response to chemical stimulus • cellular response to alcohol • response to forskolin • cellular response to lipid • cellular response to ketone • midbody • cellular anatomical structure • membrane-bounded organelle • intracellular anatomical structure • nucleus • membrane-enclosed lumen • intracellular membraneless organelle • intracellular membrane-bounded organelle • nucleolus • intracellular organelle lumen • intracellular organelle • organelle lumen • organelle • membraneless organelle
Gene Ontology	Cellular Component	• midbody • cellular anatomical structure • membrane-bounded organelle • intracellular anatomical structure • nucleus • membrane-enclosed lumen • intracellular membraneless organelle • intracellular membrane-bounded organelle • nucleolus • intracellular organelle lumen • intracellular organelle • organelle lumen • organelle • membraneless organelle • nuclear lumen • cell periphery • cell cortex • cytoplasm • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • extracellular vesicle • extracellular organelle • extracellular region • extracellular space • vesicle • extracellular membrane-bounded organelle • centrosome • microtubule organizing center • cytoskeleton • microtubule cytoskeleton • centriolar satellite • cytosol • nucleoplasm • vacuolar membrane • lytic vacuole • vacuole • lytic vacuole membrane • bounding membrane of organelle • lysosomal membrane • organelle membrane • lysosome • Golgi apparatus • endomembrane system • cilium • plasma membrane bounded cell projection • ciliary basal body • cell projection • protein binding • binding • enzyme binding • GTPase binding • protein-containing complex binding • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • multicellular organismal process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development • anatomical structure development • sensory system development • system development • cell population proliferation • cellular process • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • signal transduction • cell communication • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • response to oxygen-containing compound • cellular response to oxygen-containing compound • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to chemical stimulus • cellular response to alcohol • response to hormone • response to chemical • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • small GTPase-mediated signal transduction • Ras protein signal transduction • intracellular signal transduction • intracellular signaling cassette • phospholipase C-activating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular response to nitrogen compound • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • response to nitrogen compound • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to monoamine stimulus • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • synaptic signaling • cellular response to acetylcholine • cell-cell signaling • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • non-motile cilium • 9+0 non-motile cilium • neuron projection • photoreceptor disc membrane • photoreceptor outer segment • photoreceptor cell cilium • synapse • cell junction • molecular transducer activity • G protein-coupled receptor activity • transmembrane signaling receptor activity • signaling receptor activity • cell surface receptor signaling pathway • regulation of lipid metabolic process • primary metabolic process • metabolic process • regulation of metabolic process • lipid metabolic process • regulation of primary metabolic process • fat cell differentiation • cellular developmental process • cell differentiation • behavior • learning or memory • cognition • memory • nervous system development • cellular component organization • cellular component biogenesis • cell junction organization • cellular component assembly • cell junction assembly • synapse organization • cellular component organization or biogenesis • synapse assembly • energy derivation by oxidation of organic compounds • energy reserve metabolic process • generation of precursor metabolites and energy • plasma membrane bounded cell projection organization • cell projection organization • cell development • neuron projection development • generation of neurons • neurogenesis • neuron differentiation • neuron development • cytoplasmic vesicle • intracellular vesicle • G-protein beta-subunit binding • fibroblast proliferation
SCOP2	Domain Identifier	• Ras-like P-loop GTPases • Transducin (heterotrimeric G protein), gamma chain
SCOP2	Family Identifier	• Ras-like P-loop GTPases • Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	K6G
PDB Residues	W:W:?1
Environment Details	Open EMBL-EBI Page
Code	K6G
Name	[(2~{R})-2-oxidanyl-3-[oxidanyl-[2-(trimethyl-$l^{4}-azanyl)ethoxy]phosphoryl]oxy-propyl] hexadecanoate
Synonyms
Identifier
Formula	C24 H51 N O7 P
Molecular Weight	496.638
SMILES
PubChem
Formal Charge	0
Total Atoms	84
Total Chiral Atoms	1
Total Bonds	83
Total Aromatic Bonds	0


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	Q5T601
Sequence	>7WU4_nogp_Chain_R T S F S I L M S P F V P S T I F P V V K W I T Y V G L G I S I G S L I L C L I I E A L F W K Q I K K S Q T S H T R R I C M V N I A L S L L I A D V W F I V G A T V D T T V N P S G V C T A A V F F T H F F Y L S L F F W M L M L G I L L A Y R I I L V F H H M A Q H L M M A V G F C L G Y G C P L I I S V I T I A V T Q P S N T Y K R K D V C W L N W S N G S K P L L A F V V P A L A I V A V N F V V V L L V L T K L W R P T V G E R L S R D D K A T I I R V G K S L L I L T P L L G L T W G F G I G T I V D S Q N L A W H V I F A L L N A F Q G F F I L C F G I L L D S K L R Q L L F N K Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	8G2Y	B2	Adhesion	Adhesion	ADGRF1	Homo sapiens	-	LPC	chim(Gs-CtGq)/β1/γ2	3.44	2023-05-10	doi.org/10.1038/s41467-023-38083-7
	8G2Y (No Gprot)	B2	Adhesion	Adhesion	ADGRF1	Homo sapiens	-	LPC		3.44	2023-05-10	doi.org/10.1038/s41467-023-38083-7
	7WU3	B2	Adhesion	Adhesion	ADGRF1	Homo sapiens	-	K6G	Gs/β1/γ2	3.1	2022-04-27	doi.org/10.1038/s41586-022-04580-w
	7WU3 (No Gprot)	B2	Adhesion	Adhesion	ADGRF1	Homo sapiens	-	K6G		3.1	2022-04-27	doi.org/10.1038/s41586-022-04580-w
	7WU4	B2	Adhesion	Adhesion	ADGRF1	Homo sapiens	-	K6G	Gi1/β1/γ2	3.4	2022-04-27	doi.org/10.1038/s41586-022-04580-w
	7WU4 (No Gprot)	B2	Adhesion	Adhesion	ADGRF1	Homo sapiens	-	K6G		3.4	2022-04-27	doi.org/10.1038/s41586-022-04580-w
	7WU5	B2	Adhesion	Adhesion	ADGRF1	Homo sapiens	-	K6G	Gi1/β1/γ2	3	2022-04-27	doi.org/10.1038/s41586-022-04580-w
	7WU5 (No Gprot)	B2	Adhesion	Adhesion	ADGRF1	Homo sapiens	-	K6G		3	2022-04-27	doi.org/10.1038/s41586-022-04580-w
	7WXU	B2	Adhesion	Adhesion	ADGRF1	Homo sapiens	-	-	chim(NtGi1-Gs-CtGq)/β1/γ2	2.85	2022-09-28	doi.org/10.1038/s41467-022-33173-4
	7WXU (No Gprot)	B2	Adhesion	Adhesion	ADGRF1	Homo sapiens	-	-		2.85	2022-09-28	doi.org/10.1038/s41467-022-33173-4
	7WXW	B2	Adhesion	Adhesion	ADGRF1	Homo sapiens	-	-	chim(NtGi1-Gs)/β1/γ2	2.84	2022-09-28	doi.org/10.1038/s41467-022-33173-4
	7WXW (No Gprot)	B2	Adhesion	Adhesion	ADGRF1	Homo sapiens	-	-		2.84	2022-09-28	doi.org/10.1038/s41467-022-33173-4
	7WY0	B2	Adhesion	Adhesion	ADGRF1	Homo sapiens	-	-	chim(NtGi1L-G13)/β1/γ2	2.83	2022-09-28	doi.org/10.1038/s41467-022-33173-4
	7WY0 (No Gprot)	B2	Adhesion	Adhesion	ADGRF1	Homo sapiens	-	-		2.83	2022-09-28	doi.org/10.1038/s41467-022-33173-4
	7WZ7	B2	Adhesion	Adhesion	ADGRF1	Homo sapiens	-	-	chim(NtGi1-G12)/β1/γ2	2.83	2022-09-28	doi.org/10.1038/s41467-022-33173-4
	7WZ7 (No Gprot)	B2	Adhesion	Adhesion	ADGRF1	Homo sapiens	-	-		2.83	2022-09-28	doi.org/10.1038/s41467-022-33173-4
	7X2V	B2	Adhesion	Adhesion	ADGRF1	Homo sapiens	-	-	Gi1/β1/γ2	3.09	2022-09-28	doi.org/10.1038/s41467-022-33173-4
	7X2V (No Gprot)	B2	Adhesion	Adhesion	ADGRF1	Homo sapiens	-	-		3.09	2022-09-28	doi.org/10.1038/s41467-022-33173-4

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