Show | PDB | Class | SubFamily | Type | SubType | Species | Orthosteric Ligand | Other Ligand(s) | Protein Partners | Resolution | Date | DOI |
| 7WU3 | B2 | Adhesion | Adhesion | ADGRF1 | Homo sapiens | - | K6G | Gs/Beta1/Gamma2 | 3.1 | 2022-04-27 | 10.1038/s41586-022-04580-w |
![](/psngpcr/ligands/K6G/K6G_7WU3_W_W_1.png)
A 2D representation of the interactions of K6G in 7WU3 colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | A:A:Y391 | R:R:L681 | 3.52 | 0 | Yes | No | 4 | 7 | 2 | 1 | R:R:L681 | R:R:T622 | 4.42 | 8 | No | No | 7 | 7 | 1 | 1 | R:R:M698 | R:R:T622 | 6.02 | 8 | No | No | 8 | 7 | 1 | 1 | R:R:T622 | W:W:?1 | 4.04 | 8 | No | Yes | 7 | 0 | 1 | 0 | R:R:C626 | W:W:?1 | 4.35 | 0 | No | Yes | 7 | 0 | 1 | 0 | R:R:M677 | R:R:W674 | 4.65 | 0 | No | Yes | 6 | 9 | 1 | 2 | R:R:L705 | R:R:M677 | 4.24 | 0 | No | No | 6 | 6 | 2 | 1 | R:R:M677 | W:W:?1 | 11.63 | 0 | No | Yes | 6 | 0 | 1 | 0 | R:R:L681 | W:W:?1 | 3.79 | 8 | No | Yes | 7 | 0 | 1 | 0 | R:R:R685 | R:R:Y684 | 11.32 | 0 | No | Yes | 8 | 8 | 2 | 1 | R:R:L688 | R:R:Y684 | 3.52 | 8 | No | Yes | 6 | 8 | 1 | 1 | R:R:H691 | R:R:Y684 | 7.62 | 8 | No | Yes | 7 | 8 | 1 | 1 | R:R:M693 | R:R:Y684 | 3.59 | 8 | Yes | Yes | 5 | 8 | 2 | 1 | R:R:Y684 | W:W:?1 | 9.64 | 8 | Yes | Yes | 8 | 0 | 1 | 0 | R:R:I687 | R:R:L688 | 4.28 | 0 | No | No | 6 | 6 | 2 | 1 | R:R:L688 | W:W:?1 | 11.38 | 8 | No | Yes | 6 | 0 | 1 | 0 | R:R:H691 | R:R:M693 | 5.25 | 8 | No | Yes | 7 | 5 | 1 | 2 | R:R:H691 | W:W:?1 | 5.87 | 8 | No | Yes | 7 | 0 | 1 | 0 | R:R:M693 | R:R:M698 | 5.78 | 8 | Yes | No | 5 | 8 | 2 | 1 | R:R:M698 | W:W:?1 | 5.17 | 8 | No | Yes | 8 | 0 | 1 | 0 | R:R:G702 | W:W:?1 | 4.69 | 0 | No | Yes | 7 | 0 | 1 | 0 | R:R:V701 | W:W:?1 | 2.72 | 0 | No | Yes | 6 | 0 | 1 | 0 | |
Statistics | Value |
---|
Average Number Of Links | 10.00 | Average Number Of Links With An Hub | 1.00 | Average Interaction Strength | 6.33 | Average Nodes In Shell | 17.00 | Average Hubs In Shell | 5.00 | Average Links In Shell | 22.00 | Average Links Mediated by Hubs In Shell | 18.00 |
| ![](/psngpcr/ligands/K6G/K6G_7WU3_W_W_1_res_stats.svg) Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | ![](/psngpcr/ligands/K6G/K6G_7WU3_W_W_1_pos_stats.svg) Location of the nodes interacting with this ligand (click to enlarge 🔍) |
|
Show | PDB | Class | SubFamily | Type | SubType | Species | Orthosteric Ligand | Other Ligand(s) | Protein Partners | Resolution | Date | DOI |
| 7WU4 | B2 | Adhesion | Adhesion | ADGRF1 | Homo sapiens | - | K6G | Gi1/Beta1/Gamma2 | 3.4 | 2022-04-27 | 10.1038/s41586-022-04580-w |
![](/psngpcr/ligands/K6G/K6G_7WU4_W_W_1.png)
A 2D representation of the interactions of K6G in 7WU4 colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | R:R:L681 | R:R:T622 | 5.9 | 3 | No | Yes | 7 | 7 | 1 | 1 | R:R:R685 | R:R:T622 | 3.88 | 3 | Yes | Yes | 8 | 7 | 2 | 1 | R:R:M698 | R:R:T622 | 4.52 | 3 | No | Yes | 8 | 7 | 1 | 1 | R:R:M699 | R:R:T622 | 4.52 | 3 | Yes | Yes | 7 | 7 | 1 | 1 | R:R:T622 | W:W:?1 | 2.69 | 3 | Yes | Yes | 7 | 0 | 1 | 0 | R:R:I625 | R:R:M699 | 4.37 | 3 | No | Yes | 7 | 7 | 1 | 1 | R:R:F703 | R:R:I625 | 2.51 | 3 | Yes | No | 8 | 7 | 2 | 1 | R:R:I625 | W:W:?1 | 2.61 | 3 | No | Yes | 7 | 0 | 1 | 0 | R:R:C626 | R:R:W674 | 2.61 | 3 | No | Yes | 7 | 9 | 1 | 1 | R:R:C626 | W:W:?1 | 4.35 | 3 | No | Yes | 7 | 0 | 1 | 0 | R:R:N629 | R:R:W674 | 22.6 | 3 | No | Yes | 9 | 9 | 2 | 1 | R:R:F703 | R:R:N629 | 8.46 | 3 | Yes | No | 8 | 9 | 2 | 2 | R:R:N629 | R:R:Y707 | 5.81 | 3 | No | Yes | 9 | 9 | 2 | 2 | R:R:I630 | R:R:W674 | 3.52 | 0 | No | Yes | 8 | 9 | 2 | 1 | R:R:M677 | R:R:W674 | 4.65 | 3 | No | Yes | 6 | 9 | 1 | 1 | R:R:F703 | R:R:W674 | 8.02 | 3 | Yes | Yes | 8 | 9 | 2 | 1 | R:R:W674 | R:R:Y707 | 10.61 | 3 | Yes | Yes | 9 | 9 | 1 | 2 | R:R:W674 | W:W:?1 | 7.29 | 3 | Yes | Yes | 9 | 0 | 1 | 0 | R:R:I680 | R:R:L676 | 2.85 | 0 | No | No | 8 | 7 | 1 | 2 | R:R:L705 | R:R:M677 | 4.24 | 0 | No | No | 6 | 6 | 2 | 1 | R:R:M677 | W:W:?1 | 5.17 | 3 | No | Yes | 6 | 0 | 1 | 0 | R:R:I680 | W:W:?1 | 6.52 | 0 | No | Yes | 8 | 0 | 1 | 0 | R:R:L681 | R:R:R685 | 12.15 | 3 | No | Yes | 7 | 8 | 1 | 2 | R:R:L681 | W:W:?1 | 11.38 | 3 | No | Yes | 7 | 0 | 1 | 0 | R:R:L688 | R:R:Y684 | 7.03 | 3 | Yes | No | 6 | 8 | 1 | 1 | R:R:H691 | R:R:Y684 | 8.71 | 3 | No | No | 7 | 8 | 2 | 1 | R:R:Y684 | W:W:?1 | 31.07 | 3 | No | Yes | 8 | 0 | 1 | 0 | R:R:I687 | R:R:L688 | 7.14 | 3 | No | Yes | 6 | 6 | 1 | 1 | R:R:I687 | W:W:?1 | 2.61 | 3 | No | Yes | 6 | 0 | 1 | 0 | R:R:H691 | R:R:L688 | 2.57 | 3 | No | Yes | 7 | 6 | 2 | 1 | R:R:L688 | W:W:?1 | 5.06 | 3 | Yes | Yes | 6 | 0 | 1 | 0 | R:R:M699 | R:R:Q695 | 6.8 | 3 | Yes | No | 7 | 6 | 1 | 2 | R:R:M698 | W:W:?1 | 5.17 | 3 | No | Yes | 8 | 0 | 1 | 0 | R:R:M699 | W:W:?1 | 6.46 | 3 | Yes | Yes | 7 | 0 | 1 | 0 | R:R:G702 | W:W:?1 | 4.69 | 0 | No | Yes | 7 | 0 | 1 | 0 | R:R:F703 | R:R:Y707 | 3.09 | 3 | Yes | Yes | 8 | 9 | 2 | 2 | R:R:G702 | R:R:V701 | 1.84 | 0 | No | No | 7 | 6 | 1 | 2 | |
Statistics | Value |
---|
Average Number Of Links | 13.00 | Average Number Of Links With An Hub | 4.00 | Average Interaction Strength | 7.31 | Average Nodes In Shell | 24.00 | Average Hubs In Shell | 8.00 | Average Links In Shell | 37.00 | Average Links Mediated by Hubs In Shell | 33.00 |
| ![](/psngpcr/ligands/K6G/K6G_7WU4_W_W_1_res_stats.svg) Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | ![](/psngpcr/ligands/K6G/K6G_7WU4_W_W_1_pos_stats.svg) Location of the nodes interacting with this ligand (click to enlarge 🔍) |
|
Show | PDB | Class | SubFamily | Type | SubType | Species | Orthosteric Ligand | Other Ligand(s) | Protein Partners | Resolution | Date | DOI |
| 7WU5 | B2 | Adhesion | Adhesion | ADGRF1 | Homo sapiens | - | K6G | Gi1/Beta1/Gamma2 | 3 | 2022-04-27 | 10.1038/s41586-022-04580-w |
![](/psngpcr/ligands/K6G/K6G_7WU5_W_W_1.png)
A 2D representation of the interactions of K6G in 7WU5 colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | R:R:L681 | R:R:T622 | 7.37 | 0 | No | No | 7 | 7 | 2 | 1 | R:R:T622 | W:W:?1 | 5.39 | 0 | No | Yes | 7 | 0 | 1 | 0 | R:R:I625 | R:R:M699 | 4.37 | 0 | No | No | 7 | 7 | 1 | 2 | R:R:I625 | W:W:?1 | 5.22 | 0 | No | Yes | 7 | 0 | 1 | 0 | R:R:C626 | R:R:L678 | 3.17 | 0 | No | No | 7 | 8 | 1 | 2 | R:R:C626 | W:W:?1 | 4.35 | 0 | No | Yes | 7 | 0 | 1 | 0 | R:R:N629 | R:R:W674 | 25.99 | 3 | No | Yes | 9 | 9 | 2 | 1 | R:R:F703 | R:R:N629 | 8.46 | 3 | Yes | No | 8 | 9 | 2 | 2 | R:R:N629 | R:R:Y707 | 4.65 | 3 | No | Yes | 9 | 9 | 2 | 2 | R:R:M677 | R:R:W674 | 4.65 | 3 | Yes | Yes | 6 | 9 | 1 | 1 | R:R:F703 | R:R:W674 | 8.02 | 3 | Yes | Yes | 8 | 9 | 2 | 1 | R:R:G706 | R:R:W674 | 4.22 | 0 | No | Yes | 9 | 9 | 2 | 1 | R:R:W674 | R:R:Y707 | 7.72 | 3 | Yes | Yes | 9 | 9 | 1 | 2 | R:R:W674 | W:W:?1 | 4.16 | 3 | Yes | Yes | 9 | 0 | 1 | 0 | R:R:L676 | R:R:M677 | 4.24 | 0 | Yes | Yes | 7 | 6 | 2 | 1 | R:R:I680 | R:R:L676 | 4.28 | 0 | No | Yes | 8 | 7 | 1 | 2 | R:R:G702 | R:R:M677 | 3.49 | 3 | No | Yes | 7 | 6 | 1 | 1 | R:R:L705 | R:R:M677 | 5.65 | 0 | No | Yes | 6 | 6 | 2 | 1 | R:R:M677 | W:W:?1 | 9.04 | 3 | Yes | Yes | 6 | 0 | 1 | 0 | R:R:I680 | W:W:?1 | 6.52 | 0 | No | Yes | 8 | 0 | 1 | 0 | R:R:A683 | R:R:V761 | 3.39 | 0 | No | No | 6 | 8 | 1 | 2 | R:R:L688 | R:R:Y684 | 7.03 | 3 | No | Yes | 6 | 8 | 1 | 2 | R:R:H691 | R:R:Y684 | 6.53 | 3 | Yes | Yes | 7 | 8 | 1 | 2 | R:R:M693 | R:R:Y684 | 7.18 | 3 | No | Yes | 5 | 8 | 1 | 2 | R:R:I687 | R:R:L764 | 4.28 | 0 | No | No | 6 | 7 | 1 | 2 | R:R:I687 | W:W:?1 | 10.44 | 0 | No | Yes | 6 | 0 | 1 | 0 | R:R:H691 | R:R:L688 | 6.43 | 3 | Yes | No | 7 | 6 | 1 | 1 | R:R:L688 | W:W:?1 | 10.12 | 3 | No | Yes | 6 | 0 | 1 | 0 | R:R:H691 | R:R:M693 | 9.19 | 3 | Yes | No | 7 | 5 | 1 | 1 | R:R:H691 | W:W:?1 | 5.87 | 3 | Yes | Yes | 7 | 0 | 1 | 0 | R:R:M693 | W:W:?1 | 3.88 | 3 | No | Yes | 5 | 0 | 1 | 0 | R:R:F703 | R:R:M699 | 6.22 | 3 | Yes | No | 8 | 7 | 2 | 2 | R:R:G702 | W:W:?1 | 6.25 | 3 | No | Yes | 7 | 0 | 1 | 0 | R:R:F703 | R:R:Y707 | 3.09 | 3 | Yes | Yes | 8 | 9 | 2 | 2 | R:R:A683 | W:W:?1 | 2.88 | 0 | No | Yes | 6 | 0 | 1 | 0 | R:R:V701 | W:W:?1 | 2.72 | 0 | No | Yes | 6 | 0 | 1 | 0 | |
Statistics | Value |
---|
Average Number Of Links | 13.00 | Average Number Of Links With An Hub | 3.00 | Average Interaction Strength | 5.91 | Average Nodes In Shell | 26.00 | Average Hubs In Shell | 8.00 | Average Links In Shell | 36.00 | Average Links Mediated by Hubs In Shell | 31.00 |
| ![](/psngpcr/ligands/K6G/K6G_7WU5_W_W_1_res_stats.svg) Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | ![](/psngpcr/ligands/K6G/K6G_7WU5_W_W_1_pos_stats.svg) Location of the nodes interacting with this ligand (click to enlarge 🔍) |
|