CodeK6G
Name[(2~{R})-2-oxidanyl-3-[oxidanyl-[2-(trimethyl-$l^{4}-azanyl)ethoxy]phosphoryl]oxy-propyl] hexadecanoate
Synonyms
Identifier[(2~{R})-2-oxidanyl-3-[oxidanyl-[2-(trimethyl-$l^{4}-azanyl)ethoxy]phosphoryl]oxy-propyl] hexadecanoate
FormulaC24 H51 N O7 P
Molecular Weight496.638
SMILESCCCCCCCCCCCCCCCC(=O)OC[C@H](COP(=O)(O)OCC[N](C)(C)C)O
PubChem
Formal Charge0
Total Atoms84
Total Chiral Atoms1
Total Bonds83
Total Aromatic Bonds0
Networks3
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This ligand is also present in the following 3 networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
7WU3 B2 Adhesion Adhesion ADGRF1 Homo sapiens - K6G Gs/Beta1/Gamma2 3.1 2022-04-27 10.1038/s41586-022-04580-w

A 2D representation of the interactions of K6G in 7WU3
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
A:A:Y391 R:R:L681 3.52 0 Yes No 4 7 2 1
R:R:L681 R:R:T622 4.42 8 No No 7 7 1 1
R:R:M698 R:R:T622 6.02 8 No No 8 7 1 1
R:R:T622 W:W:?1 4.04 8 No Yes 7 0 1 0
R:R:C626 W:W:?1 4.35 0 No Yes 7 0 1 0
R:R:M677 R:R:W674 4.65 0 No Yes 6 9 1 2
R:R:L705 R:R:M677 4.24 0 No No 6 6 2 1
R:R:M677 W:W:?1 11.63 0 No Yes 6 0 1 0
R:R:L681 W:W:?1 3.79 8 No Yes 7 0 1 0
R:R:R685 R:R:Y684 11.32 0 No Yes 8 8 2 1
R:R:L688 R:R:Y684 3.52 8 No Yes 6 8 1 1
R:R:H691 R:R:Y684 7.62 8 No Yes 7 8 1 1
R:R:M693 R:R:Y684 3.59 8 Yes Yes 5 8 2 1
R:R:Y684 W:W:?1 9.64 8 Yes Yes 8 0 1 0
R:R:I687 R:R:L688 4.28 0 No No 6 6 2 1
R:R:L688 W:W:?1 11.38 8 No Yes 6 0 1 0
R:R:H691 R:R:M693 5.25 8 No Yes 7 5 1 2
R:R:H691 W:W:?1 5.87 8 No Yes 7 0 1 0
R:R:M693 R:R:M698 5.78 8 Yes No 5 8 2 1
R:R:M698 W:W:?1 5.17 8 No Yes 8 0 1 0
R:R:G702 W:W:?1 4.69 0 No Yes 7 0 1 0
R:R:V701 W:W:?1 2.72 0 No Yes 6 0 1 0
StatisticsValue
Average Number Of Links10.00
Average Number Of Links With An Hub1.00
Average Interaction Strength6.33
Average Nodes In Shell17.00
Average Hubs In Shell5.00
Average Links In Shell22.00
Average Links Mediated by Hubs In Shell18.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
7WU4 B2 Adhesion Adhesion ADGRF1 Homo sapiens - K6G Gi1/Beta1/Gamma2 3.4 2022-04-27 10.1038/s41586-022-04580-w

A 2D representation of the interactions of K6G in 7WU4
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:L681 R:R:T622 5.9 3 No Yes 7 7 1 1
R:R:R685 R:R:T622 3.88 3 Yes Yes 8 7 2 1
R:R:M698 R:R:T622 4.52 3 No Yes 8 7 1 1
R:R:M699 R:R:T622 4.52 3 Yes Yes 7 7 1 1
R:R:T622 W:W:?1 2.69 3 Yes Yes 7 0 1 0
R:R:I625 R:R:M699 4.37 3 No Yes 7 7 1 1
R:R:F703 R:R:I625 2.51 3 Yes No 8 7 2 1
R:R:I625 W:W:?1 2.61 3 No Yes 7 0 1 0
R:R:C626 R:R:W674 2.61 3 No Yes 7 9 1 1
R:R:C626 W:W:?1 4.35 3 No Yes 7 0 1 0
R:R:N629 R:R:W674 22.6 3 No Yes 9 9 2 1
R:R:F703 R:R:N629 8.46 3 Yes No 8 9 2 2
R:R:N629 R:R:Y707 5.81 3 No Yes 9 9 2 2
R:R:I630 R:R:W674 3.52 0 No Yes 8 9 2 1
R:R:M677 R:R:W674 4.65 3 No Yes 6 9 1 1
R:R:F703 R:R:W674 8.02 3 Yes Yes 8 9 2 1
R:R:W674 R:R:Y707 10.61 3 Yes Yes 9 9 1 2
R:R:W674 W:W:?1 7.29 3 Yes Yes 9 0 1 0
R:R:I680 R:R:L676 2.85 0 No No 8 7 1 2
R:R:L705 R:R:M677 4.24 0 No No 6 6 2 1
R:R:M677 W:W:?1 5.17 3 No Yes 6 0 1 0
R:R:I680 W:W:?1 6.52 0 No Yes 8 0 1 0
R:R:L681 R:R:R685 12.15 3 No Yes 7 8 1 2
R:R:L681 W:W:?1 11.38 3 No Yes 7 0 1 0
R:R:L688 R:R:Y684 7.03 3 Yes No 6 8 1 1
R:R:H691 R:R:Y684 8.71 3 No No 7 8 2 1
R:R:Y684 W:W:?1 31.07 3 No Yes 8 0 1 0
R:R:I687 R:R:L688 7.14 3 No Yes 6 6 1 1
R:R:I687 W:W:?1 2.61 3 No Yes 6 0 1 0
R:R:H691 R:R:L688 2.57 3 No Yes 7 6 2 1
R:R:L688 W:W:?1 5.06 3 Yes Yes 6 0 1 0
R:R:M699 R:R:Q695 6.8 3 Yes No 7 6 1 2
R:R:M698 W:W:?1 5.17 3 No Yes 8 0 1 0
R:R:M699 W:W:?1 6.46 3 Yes Yes 7 0 1 0
R:R:G702 W:W:?1 4.69 0 No Yes 7 0 1 0
R:R:F703 R:R:Y707 3.09 3 Yes Yes 8 9 2 2
R:R:G702 R:R:V701 1.84 0 No No 7 6 1 2
StatisticsValue
Average Number Of Links13.00
Average Number Of Links With An Hub4.00
Average Interaction Strength7.31
Average Nodes In Shell24.00
Average Hubs In Shell8.00
Average Links In Shell37.00
Average Links Mediated by Hubs In Shell33.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
7WU5 B2 Adhesion Adhesion ADGRF1 Homo sapiens - K6G Gi1/Beta1/Gamma2 3 2022-04-27 10.1038/s41586-022-04580-w

A 2D representation of the interactions of K6G in 7WU5
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:L681 R:R:T622 7.37 0 No No 7 7 2 1
R:R:T622 W:W:?1 5.39 0 No Yes 7 0 1 0
R:R:I625 R:R:M699 4.37 0 No No 7 7 1 2
R:R:I625 W:W:?1 5.22 0 No Yes 7 0 1 0
R:R:C626 R:R:L678 3.17 0 No No 7 8 1 2
R:R:C626 W:W:?1 4.35 0 No Yes 7 0 1 0
R:R:N629 R:R:W674 25.99 3 No Yes 9 9 2 1
R:R:F703 R:R:N629 8.46 3 Yes No 8 9 2 2
R:R:N629 R:R:Y707 4.65 3 No Yes 9 9 2 2
R:R:M677 R:R:W674 4.65 3 Yes Yes 6 9 1 1
R:R:F703 R:R:W674 8.02 3 Yes Yes 8 9 2 1
R:R:G706 R:R:W674 4.22 0 No Yes 9 9 2 1
R:R:W674 R:R:Y707 7.72 3 Yes Yes 9 9 1 2
R:R:W674 W:W:?1 4.16 3 Yes Yes 9 0 1 0
R:R:L676 R:R:M677 4.24 0 Yes Yes 7 6 2 1
R:R:I680 R:R:L676 4.28 0 No Yes 8 7 1 2
R:R:G702 R:R:M677 3.49 3 No Yes 7 6 1 1
R:R:L705 R:R:M677 5.65 0 No Yes 6 6 2 1
R:R:M677 W:W:?1 9.04 3 Yes Yes 6 0 1 0
R:R:I680 W:W:?1 6.52 0 No Yes 8 0 1 0
R:R:A683 R:R:V761 3.39 0 No No 6 8 1 2
R:R:L688 R:R:Y684 7.03 3 No Yes 6 8 1 2
R:R:H691 R:R:Y684 6.53 3 Yes Yes 7 8 1 2
R:R:M693 R:R:Y684 7.18 3 No Yes 5 8 1 2
R:R:I687 R:R:L764 4.28 0 No No 6 7 1 2
R:R:I687 W:W:?1 10.44 0 No Yes 6 0 1 0
R:R:H691 R:R:L688 6.43 3 Yes No 7 6 1 1
R:R:L688 W:W:?1 10.12 3 No Yes 6 0 1 0
R:R:H691 R:R:M693 9.19 3 Yes No 7 5 1 1
R:R:H691 W:W:?1 5.87 3 Yes Yes 7 0 1 0
R:R:M693 W:W:?1 3.88 3 No Yes 5 0 1 0
R:R:F703 R:R:M699 6.22 3 Yes No 8 7 2 2
R:R:G702 W:W:?1 6.25 3 No Yes 7 0 1 0
R:R:F703 R:R:Y707 3.09 3 Yes Yes 8 9 2 2
R:R:A683 W:W:?1 2.88 0 No Yes 6 0 1 0
R:R:V701 W:W:?1 2.72 0 No Yes 6 0 1 0
StatisticsValue
Average Number Of Links13.00
Average Number Of Links With An Hub3.00
Average Interaction Strength5.91
Average Nodes In Shell26.00
Average Hubs In Shell8.00
Average Links In Shell36.00
Average Links Mediated by Hubs In Shell31.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
StatisticsValue
Average Number Of Links12.00
Average Number Of Links With An Hub2.67
Average Interaction Strength6.52
Average Nodes In Shell22.33
Average Hubs In Shell7.00
Average Links In Shell31.67
Average Links Mediated by Hubs In Shell27.33

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Physico-chemical properties of the nodes interacting with this ligand

(Click to enlarge 🔍)

missing image


Location of the nodes interacting with this ligand

(Click to enlarge 🔍)