Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg Int. Strength Num Of Links Community ConSurf
1A:A:V34 5.472595
2A:A:L36 4.2575497
3A:A:L37 2.972519
4A:A:L38 5.275468
5A:A:L39 3.7675419
6A:A:K46 5.068569
7A:A:I49 5.63467
8A:A:I184 3.4925419
9A:A:F191 8.82495
10A:A:L194 7.5125494
11A:A:F196 8.818597
12A:A:K197 10.005416
13A:A:M198 3.465467
14A:A:F199 7.915415
15A:A:V201 3.435419
16A:A:Q204 5.51143719
17A:A:E207 5.388519
18A:A:K210 5.60375819
19A:A:W211 5.00286719
20A:A:F215 3.84889919
21A:A:F223 3.215419
22A:A:Y230 9.606518
23A:A:R242 7.6745119
24A:A:F250 5.04419
25A:A:I253 3.83418
26A:A:W258 5.758525
27A:A:F259 5.308519
28A:A:I264 5.5675416
29A:A:I265 4.524568
30A:A:L266 3.6975419
31A:A:F267 5.406569
32A:A:N269 6.04469
33A:A:F274 9.268519
34A:A:F307 4.31518
35A:A:R313 5.09404
36A:A:K317 7.7375417
37A:A:Y320 4.82286767
38A:A:H322 8.4475469
39A:A:F323 5.566504
40A:A:F334 7.252563
41A:A:F336 6.1125498
42A:A:V339 4.685498
43A:A:F354 5.82667605
44B:B:L7 3.38754148
45B:B:L14 3.5545158
46B:B:D27 4.3375408
47B:B:L30 3.23405
48B:B:I37 5.765422
49B:B:V40 4.364523
50B:B:M45 5.3375404
51B:B:T50 4.2275423
52B:B:L51 8.666549
53B:B:H54 8.902549
54B:B:Y59 6.808528
55B:B:W63 6.594507
56B:B:L70 4.736545
57B:B:S72 4.568549
58B:B:Q75 5.9075409
59B:B:K78 4.91408
60B:B:L79 3.9956107
61B:B:I80 8.73448
62B:B:W82 10.0317649
63B:B:Y85 9.08444
64B:B:K89 7649
65B:B:H91 4.4625105
66B:B:I93 3.7085107
67B:B:L95 4.3345108
68B:B:W99 6.23619
69B:B:Y105 5.034297106
70B:B:Y111 5.8325484
71B:B:L117 4.706519
72B:B:I120 3.5925406
73B:B:I123 4.318586
74B:B:Y124 5.7165106
75B:B:L126 4.0725105
76B:B:E130 3.8075403
77B:B:L139 4.8925489
78B:B:H142 6.87589
79B:B:Y145 4.74667918
80B:B:L146 3.9175407
81B:B:C149 4.32408
82B:B:F151 4.39167689
83B:B:L152 3.2475453
84B:B:I157 3.978587
85B:B:V158 3.9175455
86B:B:T159 5.204589
87B:B:C166 4.165458
88B:B:L168 4.73556
89B:B:W169 8.36333688
90B:B:D170 6.5225459
91B:B:T173 5.095455
92B:B:Q176 7.5425484
93B:B:F180 6.54167657
94B:B:H183 8.13667659
95B:B:M188 5.185418
96B:B:F199 5.63875859
97B:B:S201 4.23559
98B:B:C204 5.085417
99B:B:D205 6.3475409
100B:B:S207 4.07455
101B:B:K209 10.532556
102B:B:L210 6.945405
103B:B:W211 7.49714758
104B:B:C218 6.0775455
105B:B:Q220 6.01477
106B:B:F222 6.996578
107B:B:H225 7.69779
108B:B:D228 6.218519
109B:B:I232 4.35408
110B:B:F234 5.36575
111B:B:F235 6.28286726
112B:B:P236 6.015427
113B:B:F241 5.93776
114B:B:T243 5.73478
115B:B:T249 3.97676
116B:B:R251 9.81667678
117B:B:F253 7.10833676
118B:B:L255 5.205476
119B:B:D258 10.6275477
120B:B:Y264 5.39167625
121B:B:I269 4.5524
122B:B:C271 5.8775425
123B:B:F278 5.00429727
124B:B:R283 7.41833629
125B:B:L284 4.29425
126B:B:L285 4.555426
127B:B:Y289 6.4525827
128B:B:D290 7.765426
129B:B:D291 5.6625428
130B:B:C294 3.752525
131B:B:W297 4.888528
132B:B:K301 7.275405
133B:B:R304 4.76525
134B:B:H311 10.09429
135B:B:N313 3.7427
136B:B:R314 11.015428
137B:B:L318 4.15426
138B:B:M325 4.486545
139B:B:T329 4.835428
140B:B:W332 8.81286729
141B:B:D333 8.574529
142B:B:L336 6.566547
143B:B:K337 8.975426
144B:B:W339 11.67429
145B:B:N340 5.866549
146G:G:E22 3.685409
147G:G:Y40 9.255426
148G:G:D48 9.3225409
149G:G:L51 5.988526
150G:G:N59 6.818549
151G:G:P60 6.3925449
152G:G:F61 5.07125848
153R:R:S568 4.73409
154R:R:F569 4.94539
155R:R:L572 5.4125439
156R:R:P575 3.8075406
157R:R:P578 3.735404
158R:R:I581 4.55504
159R:R:F582 3.935401
160R:R:I597 2.253336187
161R:R:F610 5.8945198
162R:R:K615 11.49408
163R:R:T622 4.302537
164R:R:R624 5.994209
165R:R:S633 3.18438
166R:R:W640 5.59536
167R:R:F641 3.43539
168R:R:V647 2.4875405
169R:R:N652 4.635404
170R:R:T664 5.28437
171R:R:F667 5.72429738
172R:R:Y668 6.16167638
173R:R:S670 3.32438
174R:R:L671 3.9125407
175R:R:F673 6.8925408
176R:R:W674 8.47143739
177R:R:R685 8.298538
178R:R:L688 5.45436
179R:R:V689 6.4575499
180R:R:F690 7.09833698
181R:R:M699 5.5375437
182R:R:F703 5.52438
183R:R:Y707 5.43539
184R:R:P710 3.546509
185R:R:I713 2.6825409
186R:R:T721 4.9025129
187R:R:T726 5.914124
188R:R:Y727 6.074509
189R:R:W734 4.828538
190R:R:L735 5.69409
191R:R:N736 5.78254128
192R:R:S741 6.09754128
193R:R:P743 6.014128
194R:R:F747 5.728538
195R:R:W770 4.2406
196R:R:R777 5.6325405
197R:R:L778 1.875405
198R:R:R780 5.8975413
199R:R:L800 7.31754219
200R:R:W804 9.68539
201R:R:T810 4.24407
202R:R:F823 5.19539
203R:R:N827 7.946539
204R:R:F829 5.325407
205R:R:Q830 5.9375439
206R:R:F832 4.77405
207R:R:F833 3.645227
208R:R:F837 4.0345228
209R:R:L845 3.05254198
210W:W:?1 7.313081330
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
1B:B:G319 B:B:W63 11.64642.81NoYes057
2B:B:G319 B:B:S277 11.80213.71NoNo055
3B:B:L318 B:B:S277 11.97273YesNo065
4B:B:L318 B:B:S275 20.41066.01YesNo068
5B:B:S275 B:B:T274 20.58373.2NoNo088
6B:B:R314 B:B:T274 20.61172.59YesNo288
7B:B:R314 B:B:W332 36.809420.99YesYes289
8B:B:K57 B:B:W332 31.346113.92NoYes099
9B:B:K57 B:B:Q75 31.67126.78NoYes099
10A:A:C214 B:B:Q75 31.62344.58NoYes079
11A:A:C214 A:A:F215 31.65692.79NoYes079
12A:A:F215 A:A:L37 82.11152.44YesYes199
13A:A:L37 A:A:L39 99.92764.15YesYes199
14A:A:F223 A:A:L39 1002.44YesYes199
15A:A:F223 A:A:L266 75.00952.44YesYes199
16A:A:L266 A:A:T321 55.24234.42YesNo095
17A:A:T321 R:R:R777 54.13182.59NoYes055
18A:A:E318 R:R:R777 53.96938.14NoYes045
19A:A:E318 A:A:Y320 53.92477.86NoYes047
20A:A:I265 A:A:Y320 43.43624.84YesYes687
21A:A:I222 A:A:I265 42.91965.89NoYes078
22A:A:I222 A:A:L36 43.1797.14NoYes077
23A:A:L36 A:A:V339 41.56184.47YesYes978
24A:A:V339 R:R:F690 41.79582.62YesYes988
25A:A:I343 R:R:F690 41.54886.28NoYes978
26A:A:I343 A:A:N347 41.59292.83NoNo078
27A:A:N347 R:R:R685 41.55318.44NoYes088
28B:B:W332 B:B:Y59 32.41723.86YesYes298
29B:B:Q75 B:B:Y59 31.76557.89YesYes098
30B:B:Q75 B:B:W99 31.82614.38YesYes099
31A:A:F215 B:B:W99 31.86745.01YesYes199
32A:A:W211 B:B:Y145 35.67655.79YesYes198
33A:A:V201 A:A:W211 18.00313.68YesYes199
34B:B:H62 B:B:Y105 11.59314.36NoYes066
35B:B:H62 B:B:R150 11.680514.67NoNo066
36B:B:C148 B:B:R150 11.77022.79NoNo066
37B:B:C148 B:B:L190 21.41743.17NoNo065
38B:B:F199 B:B:L190 21.36929.74YesNo595
39B:B:C166 B:B:F199 21.3585.59YesYes589
40B:B:C166 B:B:S160 25.04693.44YesNo086
41B:B:S147 B:B:S160 35.5544.89NoNo096
42B:B:S147 B:B:Y145 35.53772.54NoYes198
43A:A:F223 A:A:F250 20.60115.36YesYes199
44A:A:F250 A:A:I264 20.32586.28YesYes196
45A:A:I264 A:A:L266 19.92644.28YesYes169
46A:A:I264 A:A:K317 39.53965.82YesYes167
47A:A:K317 A:A:R313 39.27673.71YesYes074
48A:A:R313 A:A:T260 19.798310.35YesNo043
49A:A:D261 A:A:T260 19.69318.67NoNo043
50A:A:R313 A:A:T316 19.79832.59YesNo043
51A:A:D261 A:A:T316 19.69314.34NoNo043
52A:A:D261 A:A:K349 39.14842.77NoNo045
53A:A:F354 A:A:K349 38.6752.48YesNo055
54A:A:F354 R:R:L769 41.20232.44YesNo057
55R:R:L769 R:R:S792 39.14183NoNo078
56A:A:L353 R:R:S792 38.83696.01NoNo078
57A:A:L353 R:R:L682 38.2282.77NoNo079
58B:B:C271 B:B:D290 15.84049.34YesYes256
59B:B:C271 B:B:Y289 14.03564.03YesYes257
60B:B:W297 B:B:Y289 11.35146.75YesYes287
61B:B:M45 B:B:N340 16.51394.21YesYes049
62B:B:L308 B:B:M45 30.50888.48NoYes074
63B:B:M45 G:G:L50 11.68112.83YesNo049
64B:B:L308 B:B:W339 15.608121.64NoYes079
65B:B:H311 B:B:T329 16.43945.48YesYes298
66B:B:D333 B:B:H311 24.88235.04YesYes299
67B:B:C148 B:B:T102 11.3113.38NoNo068
68B:B:C294 B:B:L308 15.58683.17YesNo057
69B:B:D333 B:B:N313 25.92262.69YesYes297
70R:R:R685 R:R:T622 21.33053.88YesYes387
71R:R:T622 W:W:?1 20.8462.69YesYes370
72R:R:W674 W:W:?1 39.06857.29YesYes390
73R:R:I630 R:R:W674 19.61193.52NoYes089
74R:R:I630 R:R:L671 19.47722.85NoYes087
75R:R:L671 R:R:M675 17.74235.65YesNo079
76R:R:F823 R:R:W804 10.02163.01YesYes399
77R:R:F823 R:R:G807 14.24743.01YesNo399
78R:R:G807 R:R:T810 14.03523.64NoYes097
79R:R:H820 R:R:T810 10.11495.48NoYes087
80R:R:L681 R:R:R685 20.904512.15NoYes378
81R:R:L681 W:W:?1 20.846211.38NoYes370
82R:R:M675 R:R:Q830 11.74612.72NoYes099
83R:R:W674 R:R:Y707 19.092810.61YesYes399
84R:R:F667 R:R:W640 10.76323.01YesYes386
85R:R:L678 R:R:L682 36.43392.77NoNo089
86R:R:L678 R:R:L800 35.11465.54NoYes2189
87R:R:L800 R:R:N758 13.384415.1YesNo099
88R:R:I754 R:R:N758 13.06134.25NoNo099
89R:R:F673 R:R:I754 12.15625.02YesNo089
90R:R:L796 R:R:L800 21.51146.92NoYes099
91R:R:L796 R:R:V762 21.17754.47NoNo098
92R:R:L802 R:R:V762 20.8462.98NoNo078
93R:R:L802 R:R:T797 19.86827.37NoNo079
94R:R:P798 R:R:T797 18.89933.5NoNo099
95R:R:F833 R:R:P798 16.92162.89YesNo2279
96R:R:F832 R:R:F833 11.73164.29YesYes057
97R:R:F832 R:R:S599 10.69862.64YesNo058
98A:A:L37 A:A:V201 18.06292.98YesYes199
99A:A:F215 A:A:W211 18.2324.01YesYes199
100B:B:S160 B:B:V187 10.42958.08NoNo069
101B:B:D290 B:B:R314 16.054915.48YesYes268
102B:B:N313 B:B:W332 26.43815.65YesYes279
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


2D representation of the interactions of this orthosteric/allosteric ligand.


Links and nodes colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:L681 R:R:T622 5.9 3 No Yes 7 7 1 1
R:R:R685 R:R:T622 3.88 3 Yes Yes 8 7 2 1
R:R:M698 R:R:T622 4.52 3 No Yes 8 7 1 1
R:R:M699 R:R:T622 4.52 3 Yes Yes 7 7 1 1
R:R:T622 W:W:?1 2.69 3 Yes Yes 7 0 1 0
R:R:I625 R:R:M699 4.37 3 No Yes 7 7 1 1
R:R:F703 R:R:I625 2.51 3 Yes No 8 7 2 1
R:R:I625 W:W:?1 2.61 3 No Yes 7 0 1 0
R:R:C626 R:R:W674 2.61 3 No Yes 7 9 1 1
R:R:C626 W:W:?1 4.35 3 No Yes 7 0 1 0
R:R:N629 R:R:W674 22.6 3 No Yes 9 9 2 1
R:R:F703 R:R:N629 8.46 3 Yes No 8 9 2 2
R:R:N629 R:R:Y707 5.81 3 No Yes 9 9 2 2
R:R:I630 R:R:W674 3.52 0 No Yes 8 9 2 1
R:R:M677 R:R:W674 4.65 3 No Yes 6 9 1 1
R:R:F703 R:R:W674 8.02 3 Yes Yes 8 9 2 1
R:R:W674 R:R:Y707 10.61 3 Yes Yes 9 9 1 2
R:R:W674 W:W:?1 7.29 3 Yes Yes 9 0 1 0
R:R:I680 R:R:L676 2.85 0 No No 8 7 1 2
R:R:L705 R:R:M677 4.24 0 No No 6 6 2 1
R:R:M677 W:W:?1 5.17 3 No Yes 6 0 1 0
R:R:I680 W:W:?1 6.52 0 No Yes 8 0 1 0
R:R:L681 R:R:R685 12.15 3 No Yes 7 8 1 2
R:R:L681 W:W:?1 11.38 3 No Yes 7 0 1 0
R:R:L688 R:R:Y684 7.03 3 Yes No 6 8 1 1
R:R:H691 R:R:Y684 8.71 3 No No 7 8 2 1
R:R:Y684 W:W:?1 31.07 3 No Yes 8 0 1 0
R:R:I687 R:R:L688 7.14 3 No Yes 6 6 1 1
R:R:I687 W:W:?1 2.61 3 No Yes 6 0 1 0
R:R:H691 R:R:L688 2.57 3 No Yes 7 6 2 1
R:R:L688 W:W:?1 5.06 3 Yes Yes 6 0 1 0
R:R:M699 R:R:Q695 6.8 3 Yes No 7 6 1 2
R:R:M698 W:W:?1 5.17 3 No Yes 8 0 1 0
R:R:M699 W:W:?1 6.46 3 Yes Yes 7 0 1 0
R:R:G702 W:W:?1 4.69 0 No Yes 7 0 1 0
R:R:F703 R:R:Y707 3.09 3 Yes Yes 8 9 2 2
R:R:G702 R:R:V701 1.84 0 No No 7 6 1 2

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

ShowSimilarityNetwork TypeNameLigandDescription
69.23Single8G2YLPC8G2Y-ADGRF1-LPC-chim(Gs-CtGq)/β1/γ2
56.25Single7WU5K6G7WU5-ADGRF1-K6G-Gi1/β1/γ2
53.33Single7WU3K6G7WU3-ADGRF1-K6G-Gs/β1/γ2
31.25Single9K1CDHA9K1C-FFA1-DHA-Gi1/β1/γ2
29.17Single5KW2PubChem 1330539535KW2-FFA1-PubChem 133053953
28.57Single5XSZGlyceryl-mono-oleate5XSZ-LPA6-Glyceryl-mono-oleate
26.32Single9K1DCholesterol9K1D-FFA2-Butanoic acid-Cholesterol-Gi1/β1/γ2
19.05Single9IYBA1D5Q9IYB-DP2-Prostaglandin-A1D5Q-Gi1/β1/γ2
17.65Single8XXUA1D5Q8XXU-DP2-A1D5Q-Gi1/β1/γ2
16.00Single5TZYMK8666; PubChem 1270535975TZY-FFA1-MK8666; PubChem 127053597
15.00Single6N48PubChem 1384542566N48-β2-BI167107-PubChem 138454256
13.04Single8XXVA1D5Q8XXV-DP2-Indomethacin-A1D5Q-Gi1/β1/γ2
11.76Single8U4PCholesterol8U4P-CXCR4-AMD3100-Cholesterol-Gi1/β1/γ2
10.53Single7CKZMevidalen7CKZ-D1-Dopamine-Mevidalen-Gs/β1/γ2
10.53Single7LJDMevidalen7LJD-D1-Dopamine-Mevidalen-Gs/β1/γ1
10.53Single7X2FMevidalen7X2F-D1-Dopamine-Mevidalen-Gs/β1/γ2
10.53Single8K9LVV98K9L-μ-Damgo-VV9-Gi3/β1/γ1
10.53Single8U4QCholesterol8U4Q-CXCR4-REGN7663-Fab-Cholesterol-Gi1/β1/γ2
10.00Single7LJCMevidalen7LJC-D1-SKF-81297-Mevidalen-Gs/β1/γ2
10.00Single8G94CD698G94-S1P1-CD69-Gi1/β1/γ2
9.09Single6C1RAvacopan; Na6C1R-C5a1-PMX53-Avacopan; Na
8.00Single7SHEPI; PE7SHE-GPR158-PI; PE
6.90Single7SHEPI; PE7SHE-GPR158-PI; PE
6.90Single7SHFPI; PE7SHF-GPR158-PI; PE-B5; RGS7
6.25Single4PXFOctyl-Beta-D-Glucopyranoside4PXF-Rhodopsin-Octyl-β-D-Glucopyranoside-Arrestin1 Finger Loop
5.88Single8U4NCholesterol8U4N-CXCR4-Cholesterol-Gi1/β1/γ2
5.56Single6KQIOrg275696KQI-CB1-CP55940-Org27569
5.26Single6OBAGTPL110746OBA-β2-S-Alprenolol-GTPL11074
5.26Single8U4OCholesterol8U4O-CXCR4-CXCL12-Cholesterol-Gi1/β1/γ2
5.26Single8U4RCholesterol8U4R-CXCR4-REGN7663-Fab-Cholesterol
4.76Single6C1QNDT95137276C1Q-C5a1-PMX53-NDT9513727
4.55Single5O9HNDT95137275O9H-C5a1-NDT9513727
4.55Single8IYXYL-3658IYX-GPR34-YL-365
3.70Single7SHFPI; PE7SHF-GPR158-PI; PE-B5; RGS7

PDB Summary
PDB 7WU4
Class B2
SubFamily Adhesion
Type Adhesion
SubType ADGRF1
Species Homo Sapiens
Ligand -
Other Ligand(s) K6G
Protein Partners Gi1/Beta1/Gamma2
PDB Resolution 3.4
Date 2022-04-27
D.O.I. 10.1038/s41586-022-04580-w
Net Summary
Imin 2.44
Number of Linked Nodes 842
Number of Links 1123
Number of Hubs 210
Number of Links mediated by Hubs 754
Number of Communities 23
Number of Nodes involved in Communities 307
Number of Links involved in Communities 488
Path Summary
Number Of Nodes in MetaPath 103
Number Of Links MetaPath 102
Number of Shortest Paths 4456634
Length Of Smallest Path 3
Average Path Length 33.6667
Length of Longest Path 54
Minimum Path Strength 1.295
Average Path Strength 5.43287
Maximum Path Strength 21.225
Minimum Path Correlation 0.71
Average Path Correlation 0.993743
Maximum Path Correlation 1
Minimum % Of Corr. Nodes 3.0303
Average % Of Corr. Nodes 38.853
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 59.5118
Maximum Path Hubs % 100
AnnotationTypeLinks
Gene OntologyMolecular Function• D2 dopamine receptor binding   • protein binding   • binding   • signaling receptor binding   • G protein-coupled receptor binding   • dopamine receptor binding   • phosphorus-oxygen lyase activity   • enzyme regulator activity   • cyclase regulator activity   • molecular function regulator activity   • cyclase activity   • adenylate cyclase regulator activity   • lyase activity   • catalytic activity   • adenylate cyclase activity   • guanyl nucleotide binding   • GTP binding   • nucleotide binding   • guanyl ribonucleotide binding   • purine ribonucleotide binding   • purine ribonucleoside triphosphate binding   • nucleoside phosphate binding   • ion binding   • purine nucleotide binding   • anion binding   • heterocyclic compound binding   • carbohydrate derivative binding   • ribonucleotide binding   • small molecule binding   • cation binding   • magnesium ion binding   • metal ion binding   • GDP binding   • G protein-coupled serotonin receptor binding   • protein-containing complex binding   • G-protein beta/gamma-subunit complex binding   • pyrophosphatase activity   • GTPase activity   • G protein activity   • ribonucleoside triphosphate phosphatase activity   • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides   • hydrolase activity   • hydrolase activity, acting on acid anhydrides   • cellular response to stimulus   • regulation of biological process   • regulation of cellular process   • response to stimulus   • signaling   • biological regulation   • adenylate cyclase-inhibiting serotonin receptor signaling pathway   • G protein-coupled serotonin receptor signaling pathway   • cell communication   • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway   • adenylate cyclase-modulating G protein-coupled receptor signaling pathway   • G protein-coupled receptor signaling pathway   • cellular process   • signal transduction
Gene OntologyBiological Process• cellular response to stimulus   • regulation of biological process   • regulation of cellular process   • response to stimulus   • signaling   • biological regulation   • adenylate cyclase-inhibiting serotonin receptor signaling pathway   • G protein-coupled serotonin receptor signaling pathway   • cell communication   • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway   • adenylate cyclase-modulating G protein-coupled receptor signaling pathway   • G protein-coupled receptor signaling pathway   • cellular process   • signal transduction   • response to hormone   • response to chemical   • response to endogenous stimulus   • response to peptide hormone   • response to oxygen-containing compound   • response to nitrogen compound   • cell division   • leukocyte migration   • immune system process   • mononuclear cell migration   • lymphocyte migration   • cell migration   • T cell migration   • cell motility   • regulation of steroid biosynthetic process   • regulation of cholesterol biosynthetic process   • regulation of cholesterol metabolic process   • steroid metabolic process   • regulation of lipid metabolic process   • sterol metabolic process   • positive regulation of biological process   • cholesterol metabolic process   • lipid biosynthetic process   • alcohol metabolic process   • regulation of primary metabolic process   • positive regulation of metabolic process   • regulation of small molecule metabolic process   • positive regulation of biosynthetic process   • positive regulation of lipid metabolic process   • small molecule metabolic process   • steroid biosynthetic process   • positive regulation of cellular process   • regulation of biosynthetic process   • secondary alcohol biosynthetic process   • regulation of alcohol biosynthetic process   • small molecule biosynthetic process   • regulation of steroid metabolic process   • cholesterol biosynthetic process   • positive regulation of cholesterol biosynthetic process   • primary metabolic process   • secondary alcohol metabolic process   • positive regulation of steroid biosynthetic process   • biosynthetic process   • sterol biosynthetic process   • positive regulation of lipid biosynthetic process   • regulation of sterol biosynthetic process   • alcohol biosynthetic process   • positive regulation of cholesterol metabolic process   • positive regulation of steroid metabolic process   • metabolic process   • regulation of lipid biosynthetic process   • positive regulation of small molecule metabolic process   • regulation of metabolic process   • positive regulation of alcohol biosynthetic process   • positive regulation of sterol biosynthetic process   • lipid metabolic process   • regulation of cytoskeleton organization   • regulation of cellular component organization   • microtubule cytoskeleton organization   • regulation of mitotic spindle organization   • mitotic cell cycle   • cellular component organization   • cell cycle   • cellular component organization or biogenesis   • regulation of cell cycle   • microtubule cytoskeleton organization involved in mitosis   • spindle organization   • cell cycle process   • regulation of cell cycle process   • regulation of microtubule-based process   • regulation of spindle organization   • regulation of organelle organization   • mitotic spindle organization   • organelle organization   • mitotic cell cycle process   • microtubule-based process   • cytoskeleton organization   • regulation of microtubule cytoskeleton organization   • protein localization   • positive regulation of protein localization to cell periphery   • regulation of localization   • protein localization to cell periphery   • cellular localization   • regulation of protein localization   • positive regulation of protein localization to cell cortex   • regulation of protein localization to cell periphery   • localization   • regulation of cellular localization   • regulation of protein localization to cell cortex   • cellular macromolecule localization   • macromolecule localization   • positive regulation of protein localization   • protein localization to cell cortex   • response to ketone   • response to prostaglandin   • response to lipid   • response to alcohol   • response to prostaglandin E   • cellular response to forskolin   • cellular response to oxygen-containing compound   • cellular response to chemical stimulus   • cellular response to alcohol   • response to forskolin   • cellular response to lipid   • cellular response to ketone   • midbody   • cellular anatomical structure   • membrane-bounded organelle   • intracellular anatomical structure   • nucleus   • membrane-enclosed lumen   • intracellular membraneless organelle   • intracellular membrane-bounded organelle   • nucleolus   • intracellular organelle lumen   • intracellular organelle   • organelle lumen   • organelle   • membraneless organelle
Gene OntologyCellular Component• midbody   • cellular anatomical structure   • membrane-bounded organelle   • intracellular anatomical structure   • nucleus   • membrane-enclosed lumen   • intracellular membraneless organelle   • intracellular membrane-bounded organelle   • nucleolus   • intracellular organelle lumen   • intracellular organelle   • organelle lumen   • organelle   • membraneless organelle   • nuclear lumen   • cell periphery   • cell cortex   • cytoplasm   • protein-containing complex   • extrinsic component of plasma membrane   • catalytic complex   • plasma membrane protein complex   • cytoplasmic side of membrane   • membrane   • plasma membrane   • membrane protein complex   • heterotrimeric G-protein complex   • side of membrane   • cytoplasmic side of plasma membrane   • GTPase complex   • extrinsic component of membrane   • extrinsic component of cytoplasmic side of plasma membrane   • extracellular exosome   • extracellular vesicle   • extracellular organelle   • extracellular region   • extracellular space   • vesicle   • extracellular membrane-bounded organelle   • centrosome   • microtubule organizing center   • cytoskeleton   • microtubule cytoskeleton   • centriolar satellite   • cytosol   • nucleoplasm   • vacuolar membrane   • lytic vacuole   • vacuole   • lytic vacuole membrane   • bounding membrane of organelle   • lysosomal membrane   • organelle membrane   • lysosome   • Golgi apparatus   • endomembrane system   • cilium   • plasma membrane bounded cell projection   • ciliary basal body   • cell projection   • protein binding   • binding   • enzyme binding   • GTPase binding   • protein-containing complex binding   • pyrophosphatase activity   • GTPase activity   • ribonucleoside triphosphate phosphatase activity   • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides   • hydrolase activity   • hydrolase activity, acting on acid anhydrides   • catalytic activity   • signaling receptor complex adaptor activity   • protein-macromolecule adaptor activity   • molecular adaptor activity   • signaling adaptor activity   • multicellular organismal process   • system process   • sensory perception of chemical stimulus   • sensory perception   • nervous system process   • sensory perception of taste   • developmental process   • sensory organ development   • eye development   • animal organ development   • retina development in camera-type eye   • visual system development   • multicellular organism development   • camera-type eye development   • anatomical structure development   • sensory system development   • system development   • cell population proliferation   • cellular process   • cellular response to stimulus   • regulation of biological process   • regulation of cellular process   • response to stimulus   • signaling   • biological regulation   • signal transduction   • cell communication   • response to ketone   • response to prostaglandin   • response to lipid   • response to endogenous stimulus   • response to alcohol   • cellular response to prostaglandin stimulus   • response to oxygen-containing compound   • cellular response to oxygen-containing compound   • cellular response to endogenous stimulus   • cellular response to prostaglandin E stimulus   • cellular response to chemical stimulus   • cellular response to alcohol   • response to hormone   • response to chemical   • cellular response to lipid   • response to prostaglandin E   • cellular response to ketone   • cellular response to hormone stimulus   • small GTPase-mediated signal transduction   • Ras protein signal transduction   • intracellular signal transduction   • intracellular signaling cassette   • phospholipase C-activating G protein-coupled receptor signaling pathway   • G protein-coupled receptor signaling pathway   • cellular response to nitrogen compound   • response to dopamine   • cellular response to dopamine   • response to monoamine   • response to catecholamine   • adenylate cyclase-activating dopamine receptor signaling pathway   • cellular response to catecholamine stimulus   • G protein-coupled dopamine receptor signaling pathway   • response to nitrogen compound   • adenylate cyclase-activating G protein-coupled receptor signaling pathway   • cellular response to monoamine stimulus   • adenylate cyclase-modulating G protein-coupled receptor signaling pathway   • synaptic signaling   • cellular response to acetylcholine   • cell-cell signaling   • acetylcholine receptor signaling pathway   • postsynaptic signal transduction   • G protein-coupled acetylcholine receptor signaling pathway   • response to acetylcholine   • non-motile cilium   • 9+0 non-motile cilium   • neuron projection   • photoreceptor disc membrane   • photoreceptor outer segment   • photoreceptor cell cilium   • synapse   • cell junction   • G-protein beta-subunit binding   • fibroblast proliferation   • molecular transducer activity   • G protein-coupled receptor activity   • transmembrane signaling receptor activity   • signaling receptor activity   • cell surface receptor signaling pathway   • regulation of lipid metabolic process   • primary metabolic process   • metabolic process   • regulation of metabolic process   • lipid metabolic process   • regulation of primary metabolic process   • fat cell differentiation   • cellular developmental process   • cell differentiation   • behavior   • learning or memory   • cognition   • memory   • nervous system development   • cellular component organization   • cellular component biogenesis   • cell junction organization   • cellular component assembly   • cell junction assembly   • synapse organization   • cellular component organization or biogenesis   • synapse assembly   • energy derivation by oxidation of organic compounds   • energy reserve metabolic process   • generation of precursor metabolites and energy   • plasma membrane bounded cell projection organization   • cell projection organization   • cell development   • neuron projection development   • generation of neurons   • neurogenesis   • neuron differentiation   • neuron development   • cytoplasmic vesicle   • intracellular vesicle
SCOP2Domain Identifier• Ras-like P-loop GTPases   • Transducin (heterotrimeric G protein), gamma chain
SCOP2Family Identifier• Ras-like P-loop GTPases   • Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations-• Orientations of Proteins in Membranes database (OPM)   • Protein Data Bank of Transmembrane Proteins (PDBTM)   • MemProtMD


Details about the values in these tables can be found in the corresponding documentation page .
CodeK6G
PDB ResiduesW:W:?1
Environment DetailsOpen EMBL-EBI Page
CodeK6G
Name[(2~{R})-2-oxidanyl-3-[oxidanyl-[2-(trimethyl-$l^{4}-azanyl)ethoxy]phosphoryl]oxy-propyl] hexadecanoate
Synonyms
Identifier
FormulaC24 H51 N O7 P
Molecular Weight496.638
SMILES
PubChem
Formal Charge0
Total Atoms84
Total Chiral Atoms1
Total Bonds83
Total Aromatic Bonds0

PDBsumOpen PDBsum Page
ChainA
ProteinG Protein α Sub unit
UniProtP63096
Sequence
>7WU4_Chain_A
KAAVERSKM IDRNLREDG EKAAREVKL LLLGADNSG KSTIVKQMT 
GIVETHFTF KDLHFKMFD VGGQRSERK KWIHCFEDV AAIIFCVDL 
SDYNRMHES MKLFDSICN NKWFTDTSI ILFLNKKDL FEEKIKKSP 
LTICYQEYA GSNTYEEAA AYIQCQFED LNKRKDTKE IYTHFTCAT 
DTKNAQFIF DAVTDVIIK NNLKDCGLF


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainB
ProteinG Protein β Sub unit
UniProtP62873
Sequence
>7WU4_Chain_B
SELDQLRQE AEQLKNQIR DARKACADA TLSQITNNI DPVGRIQMR 
TRRTLRGHL AKIYAMHWG TDSRLLVSA SQDGKLIIW DSYTTNKVH 
AIPLRSSWV MTCAYAPSG NYVACGGLD NICSIYNLK TREGNVRVS 
RELAGHTGY LSCCRFLDD NQIVTSSGD TTCALWDIE TGQQTTTFT 
GHTGDVMSL SLAPDTRLF VSGACDASA KLWDVREGM CRQTFTGHE 
SDINAICFF PNGNAFATG SDDATCRLF DLRADQELM TYSHDNIIC 
GITSVSFSK SGRLLLAGY DDFNCNVWD ALKADRAGV LAGHDNRVS 
CLGVTDDGM AVATGSWDS FLKIWN


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainG
ProteinG Protein γ Sub unit
UniProtP59768
Sequence
>7WU4_Chain_G
ASIAQARKL VEQLKMEAN IDRIKVSKA AADLMAYCE AHAKEDPLL 
TPVPASENP FR


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainR
ProteinReceptor
UniProtQ5T601
Sequence
>7WU4_Chain_R
TSFSILMSP FVPSTIFPV VKWITYVGL GISIGSLIL CLIIEALFW 
KQIKKSQTS HTRRICMVN IALSLLIAD VWFIVGATV DTTVNPSGV 
CTAAVFFTH FFYLSLFFW MLMLGILLA YRIILVFHH MAQHLMMAV 
GFCLGYGCP LIISVITIA VTQPSNTYK RKDVCWLNW SNGSKPLLA 
FVVPALAIV AVNFVVVLL VLTKLWRPT VGERLSRDD KATIIRVGK 
SLLILTPLL GLTWGFGIG TIVDSQNLA WHVIFALLN AFQGFFILC 
FGILLDSKL RQLLFNK


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  




This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
8G2YB2AdhesionAdhesionADGRF1Homo sapiens-LPCchim(Gs-CtGq)/β1/γ23.442023-05-1010.1038/s41467-023-38083-7
8G2Y (No Gprot) B2AdhesionAdhesionADGRF1Homo sapiens-LPC3.442023-05-1010.1038/s41467-023-38083-7
7WZ7B2AdhesionAdhesionADGRF1Homo sapiens--chim(NtGi1-G12)/β1/γ22.832022-09-2810.1038/s41467-022-33173-4
7WZ7 (No Gprot) B2AdhesionAdhesionADGRF1Homo sapiens--2.832022-09-2810.1038/s41467-022-33173-4
7WXUB2AdhesionAdhesionADGRF1Homo sapiens--chim(NtGi1-Gs-CtGq)/β1/γ22.852022-09-2810.1038/s41467-022-33173-4
7WXU (No Gprot) B2AdhesionAdhesionADGRF1Homo sapiens--2.852022-09-2810.1038/s41467-022-33173-4
7WXWB2AdhesionAdhesionADGRF1Homo sapiens--chim(NtGi1-Gs)/β1/γ22.842022-09-2810.1038/s41467-022-33173-4
7WXW (No Gprot) B2AdhesionAdhesionADGRF1Homo sapiens--2.842022-09-2810.1038/s41467-022-33173-4
7WY0B2AdhesionAdhesionADGRF1Homo sapiens--chim(NtGi1L-G13)/β1/γ22.832022-09-2810.1038/s41467-022-33173-4
7WY0 (No Gprot) B2AdhesionAdhesionADGRF1Homo sapiens--2.832022-09-2810.1038/s41467-022-33173-4
7X2VB2AdhesionAdhesionADGRF1Homo sapiens--Gi1/β1/γ23.092022-09-2810.1038/s41467-022-33173-4
7X2V (No Gprot) B2AdhesionAdhesionADGRF1Homo sapiens--3.092022-09-2810.1038/s41467-022-33173-4
7WU5B2AdhesionAdhesionADGRF1Homo sapiens-K6GGi1/β1/γ232022-04-2710.1038/s41586-022-04580-w
7WU5 (No Gprot) B2AdhesionAdhesionADGRF1Homo sapiens-K6G32022-04-2710.1038/s41586-022-04580-w
7WU4B2AdhesionAdhesionADGRF1Homo sapiens-K6GGi1/β1/γ23.42022-04-2710.1038/s41586-022-04580-w
7WU4 (No Gprot) B2AdhesionAdhesionADGRF1Homo sapiens-K6G3.42022-04-2710.1038/s41586-022-04580-w
7WU3B2AdhesionAdhesionADGRF1Homo sapiens-K6GGs/β1/γ23.12022-04-2710.1038/s41586-022-04580-w
7WU3 (No Gprot) B2AdhesionAdhesionADGRF1Homo sapiens-K6G3.12022-04-2710.1038/s41586-022-04580-w




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