Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg Int. Strength Num Of Links Community ConSurf
1A:A:V34 5.472595
2A:A:L36 4.2575497
3A:A:L37 2.972519
4A:A:L38 5.275458
5A:A:L39 3.7675419
6A:A:K46 5.068559
7A:A:I49 5.63457
8A:A:I184 3.4925419
9A:A:F191 8.82495
10A:A:L194 7.5125494
11A:A:F196 8.818597
12A:A:K197 10.005416
13A:A:M198 3.465457
14A:A:F199 7.915415
15A:A:V201 3.435419
16A:A:Q204 5.51143719
17A:A:E207 5.388519
18A:A:K210 5.60375819
19A:A:W211 5.50333619
20A:A:F215 3.84889919
21A:A:F223 3.215419
22A:A:D226 7.5554128
23A:A:D229 7.2554128
24A:A:Y230 8.172518
25A:A:R242 7.7856129
26A:A:F250 5.04419
27A:A:I253 5.318518
28A:A:W258 5.758525
29A:A:F259 5.308519
30A:A:I264 5.5675416
31A:A:I265 4.524558
32A:A:L266 3.6975419
33A:A:F267 5.406559
34A:A:N269 6.04459
35A:A:K270 4.26254129
36A:A:K271 4.6125405
37A:A:F274 10.965409
38A:A:F307 4.31518
39A:A:R313 5.09404
40A:A:K317 7.7375417
41A:A:Y320 4.82286757
42A:A:H322 8.4475459
43A:A:F323 5.566504
44A:A:Q333 7.105495
45A:A:F334 7.252553
46A:A:F336 6.1125498
47A:A:V339 4.685498
48A:A:F354 5.82667605
49B:B:L7 3.38754168
50B:B:L14 3.5545178
51B:B:D27 4.3375408
52B:B:L30 3.23405
53B:B:I37 5.765422
54B:B:V40 4.364523
55B:B:M45 5.3375404
56B:B:T50 4.22754113
57B:B:L51 8.666549
58B:B:H54 8.902549
59B:B:Y59 6.808528
60B:B:W63 6.594507
61B:B:L70 4.736545
62B:B:S72 4.568549
63B:B:Q75 5.9075409
64B:B:K78 4.91408
65B:B:L79 3.9956107
66B:B:I80 8.73448
67B:B:W82 10.0317649
68B:B:Y85 9.08444
69B:B:K89 7649
70B:B:H91 4.4625105
71B:B:I93 3.7085107
72B:B:L95 4.3345108
73B:B:W99 6.23619
74B:B:Y105 5.034297106
75B:B:Y111 5.8325484
76B:B:L117 4.706519
77B:B:I120 3.5925406
78B:B:I123 4.318586
79B:B:Y124 5.7165106
80B:B:L126 4.0725105
81B:B:L139 4.8925489
82B:B:H142 6.87589
83B:B:Y145 4.74667918
84B:B:L146 3.9175407
85B:B:C149 4.32408
86B:B:F151 4.39167689
87B:B:L152 3.2475463
88B:B:I157 3.978587
89B:B:V158 3.9175465
90B:B:T159 5.204589
91B:B:C166 4.165468
92B:B:L168 4.73566
93B:B:W169 8.36333688
94B:B:Q176 7.5425484
95B:B:F180 6.54167667
96B:B:H183 8.13667669
97B:B:M188 5.185418
98B:B:F199 5.63875869
99B:B:S201 4.23569
100B:B:C204 5.085417
101B:B:D205 6.3475409
102B:B:S207 4.07465
103B:B:K209 10.532566
104B:B:L210 6.945405
105B:B:W211 7.49714768
106B:B:C218 6.0775465
107B:B:Q220 6.01477
108B:B:F222 6.996578
109B:B:H225 7.69779
110B:B:D228 6.218519
111B:B:I232 4.35408
112B:B:F234 5.36575
113B:B:F235 6.28286726
114B:B:P236 6.015427
115B:B:F241 5.93776
116B:B:T243 5.73478
117B:B:T249 3.97676
118B:B:R251 9.81667678
119B:B:F253 7.10833676
120B:B:L255 5.205476
121B:B:D258 10.6275477
122B:B:Y264 5.39167625
123B:B:I269 4.5524
124B:B:C271 5.8775425
125B:B:F278 5.00429727
126B:B:R283 7.41833629
127B:B:L284 4.29425
128B:B:L285 4.555426
129B:B:Y289 6.4525827
130B:B:D290 7.765426
131B:B:D291 5.6625428
132B:B:C294 3.7525115
133B:B:W297 4.888528
134B:B:K301 7.275405
135B:B:R304 4.76525
136B:B:H311 10.094119
137B:B:R314 11.015428
138B:B:L318 4.154116
139B:B:M325 4.486545
140B:B:T329 4.8354118
141B:B:W332 8.81286729
142B:B:D333 7.5085119
143B:B:L336 6.566547
144B:B:K337 8.9754116
145B:B:W339 11.674119
146B:B:N340 5.866549
147G:G:E22 3.685409
148G:G:Y40 9.255426
149G:G:D48 9.3225409
150G:G:L51 5.988526
151G:G:N59 5.132549
152G:G:P60 6.3925449
153G:G:F61 5.07125848
154R:R:S568 4.73409
155R:R:F569 4.94539
156R:R:L572 5.4125439
157R:R:P575 3.8075406
158R:R:P578 3.735404
159R:R:I581 4.55504
160R:R:F582 3.935401
161R:R:I597 2.253336207
162R:R:F610 5.8945218
163R:R:K615 11.49408
164R:R:T622 4.302537
165R:R:R624 5.994229
166R:R:S633 3.18438
167R:R:W640 5.59536
168R:R:F641 3.43539
169R:R:V647 2.4875405
170R:R:T664 5.28437
171R:R:F667 5.72429738
172R:R:Y668 6.16167638
173R:R:S670 3.32438
174R:R:L671 3.9125407
175R:R:F673 6.8925408
176R:R:W674 8.47143739
177R:R:R685 8.298538
178R:R:L688 5.45436
179R:R:V689 6.4575499
180R:R:F690 7.09833698
181R:R:M699 5.5375437
182R:R:F703 5.52438
183R:R:Y707 5.43539
184R:R:P710 3.546509
185R:R:I713 2.6825409
186R:R:T721 4.9025139
187R:R:T726 5.914134
188R:R:Y727 6.074509
189R:R:W734 4.828538
190R:R:L735 5.69409
191R:R:N736 5.78254138
192R:R:S741 6.09754138
193R:R:P743 6.014138
194R:R:F747 5.728538
195R:R:W770 4.2406
196R:R:R777 5.6325405
197R:R:L778 1.875405
198R:R:R780 5.8975413
199R:R:L800 7.31754239
200R:R:W804 9.68539
201R:R:T810 4.24407
202R:R:F823 5.19539
203R:R:N827 7.946539
204R:R:F829 5.325407
205R:R:Q830 5.9375439
206R:R:F832 4.77405
207R:R:F833 3.645247
208R:R:F837 4.0345248
209R:R:L845 3.05254218
210W:W:?1 7.313081330
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
1B:B:G319 B:B:W63 11.54542.81NoYes057
2B:B:G319 B:B:S277 11.69943.71NoNo055
3B:B:L318 B:B:S277 11.8693YesNo065
4B:B:L318 B:B:S275 20.23886.01YesNo068
5B:B:S275 B:B:T274 20.41063.2NoNo088
6B:B:R314 B:B:T274 20.44292.59YesNo288
7B:B:R314 B:B:W332 36.513320.99YesYes289
8B:B:K57 B:B:W332 31.096813.92NoYes099
9B:B:K57 B:B:Q75 31.41956.78NoYes099
10A:A:C214 B:B:Q75 31.37584.58NoYes079
11A:A:C214 A:A:F215 31.40942.79NoYes079
12A:A:F215 A:A:L37 81.71482.44YesYes199
13A:A:L37 A:A:L39 99.77844.15YesYes199
14A:A:F223 A:A:L39 1002.44YesYes199
15A:A:F223 A:A:L266 73.82882.44YesYes199
16A:A:L266 A:A:T321 55.21774.42YesNo095
17A:A:T321 R:R:R777 52.60252.59NoYes055
18A:A:E318 R:R:R777 52.4478.14NoYes045
19A:A:E318 A:A:Y320 52.40397.86NoYes047
20A:A:I265 A:A:Y320 42.20234.84YesYes587
21A:A:I222 A:A:I265 41.28835.89NoYes078
22A:A:I222 A:A:L36 40.76487.14NoYes077
23A:A:L36 A:A:V339 39.73874.47YesYes978
24A:A:V339 R:R:F690 39.96172.62YesYes988
25A:A:I343 R:R:F690 40.28256.28NoYes978
26A:A:I343 A:A:N347 40.32322.83NoNo078
27A:A:N347 R:R:R685 40.28398.44NoYes088
28B:B:W332 B:B:Y59 32.15033.86YesYes298
29B:B:Q75 B:B:Y59 31.5137.89YesYes098
30B:B:Q75 B:B:W99 31.57044.38YesYes099
31A:A:F215 B:B:W99 31.61785.01YesYes199
32A:A:W211 B:B:Y145 36.09625.79YesYes198
33A:A:V201 A:A:W211 18.17123.68YesYes199
34B:B:H62 B:B:Y105 11.80714.36NoYes066
35B:B:H62 B:B:R150 11.895114.67NoNo066
36B:B:C148 B:B:R150 11.98562.79NoNo066
37B:B:C148 B:B:L190 21.20623.17NoNo065
38B:B:F199 B:B:L190 21.15769.74YesNo695
39B:B:C166 B:B:F199 19.58675.59YesYes689
40B:B:C166 B:B:S160 23.32333.44YesNo086
41B:B:S147 B:B:S160 35.99054.89NoNo096
42B:B:S147 B:B:Y145 35.97512.54NoYes198
43A:A:F223 A:A:F250 19.62495.36YesYes199
44A:A:F250 A:A:I264 19.2126.28YesYes196
45A:A:I264 A:A:L266 18.78994.28YesYes169
46A:A:I264 A:A:K317 37.3125.82YesYes167
47A:A:K317 A:A:R313 37.05373.71YesYes074
48A:A:R313 A:A:T260 18.74810.35YesNo043
49A:A:D261 A:A:T260 18.64618.67NoNo043
50A:A:R313 A:A:T316 18.7482.59YesNo043
51A:A:D261 A:A:T316 18.64614.34NoNo043
52A:A:D261 A:A:K349 37.06212.77NoNo045
53A:A:F354 A:A:K349 36.60382.48YesNo055
54A:A:F354 R:R:L769 39.37962.44YesNo057
55R:R:L769 R:R:S792 37.97093NoNo078
56A:A:L353 R:R:S792 37.67556.01NoNo078
57A:A:L353 R:R:L682 37.08592.77NoNo079
58B:B:K209 B:B:T221 10.249116.52YesNo667
59B:B:T221 G:G:E22 11.19885.64NoYes079
60B:B:Q220 G:G:E22 12.04132.55YesYes079
61B:B:C271 B:B:D290 15.71079.34YesYes256
62B:B:C271 B:B:Y289 13.92234.03YesYes257
63B:B:W297 B:B:Y289 11.26186.75YesYes287
64B:B:M45 B:B:N340 16.3874.21YesYes049
65B:B:L308 B:B:M45 30.24898.48NoYes074
66B:B:M45 G:G:L50 11.59272.83YesNo049
67B:B:L308 B:B:W339 15.475721.64NoYes079
68B:B:H311 B:B:T329 16.30295.48YesYes1198
69B:B:D333 B:B:H311 24.67695.04YesYes1199
70B:B:C148 B:B:T102 10.72163.38NoNo068
71B:B:C294 B:B:L308 15.45523.17YesNo057
72B:B:D333 B:B:N313 25.88622.69YesNo097
73R:R:R685 R:R:T622 20.71863.88YesYes387
74R:R:T622 W:W:?1 20.24592.69YesYes370
75R:R:W674 W:W:?1 37.92387.29YesYes390
76R:R:I630 R:R:W674 19.15313.52NoYes089
77R:R:I630 R:R:L671 19.02182.85NoYes087
78R:R:L671 R:R:M675 17.32895.65YesNo079
79R:R:F823 R:R:G807 13.88513.01YesNo399
80R:R:G807 R:R:T810 13.68373.64NoYes097
81R:R:L681 R:R:R685 20.303212.15NoYes378
82R:R:L681 W:W:?1 20.246111.38NoYes370
83R:R:M675 R:R:Q830 11.48462.72NoYes099
84R:R:W674 R:R:Y707 18.414910.61YesYes399
85R:R:F667 R:R:W640 10.23953.01YesYes386
86R:R:L678 R:R:L682 35.30882.77NoNo089
87R:R:L678 R:R:L800 34.03115.54NoYes2389
88R:R:L800 R:R:N758 12.985915.1YesNo099
89R:R:I754 R:R:N758 12.67294.25NoNo099
90R:R:F673 R:R:I754 11.80315.02YesNo089
91R:R:L796 R:R:L800 20.83186.92NoYes099
92R:R:L796 R:R:V762 20.50854.47NoNo098
93R:R:L802 R:R:V762 20.18762.98NoNo078
94R:R:L802 R:R:T797 19.24087.37NoNo079
95R:R:P798 R:R:T797 18.30233.5NoNo099
96R:R:F833 R:R:P798 16.38712.89YesNo2479
97R:R:F832 R:R:F833 11.38294.29YesYes057
98R:R:F832 R:R:S599 10.38062.64YesNo058
99A:A:L37 A:A:V201 18.2322.98YesYes199
100A:A:F215 A:A:W211 18.4184.01YesYes199
101B:B:S160 B:B:V187 12.59038.08NoNo069
102B:B:H183 B:B:V187 11.63188.3YesNo699
103B:B:D290 B:B:R314 15.927815.48YesYes268
104B:B:N313 B:B:W332 26.22065.65NoYes079
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


2D representation of the interactions of this orthosteric/allosteric ligand.


Links and nodes colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:L681 R:R:T622 5.9 3 No Yes 7 7 1 1
R:R:R685 R:R:T622 3.88 3 Yes Yes 8 7 2 1
R:R:M698 R:R:T622 4.52 3 No Yes 8 7 1 1
R:R:M699 R:R:T622 4.52 3 Yes Yes 7 7 1 1
R:R:T622 W:W:?1 2.69 3 Yes Yes 7 0 1 0
R:R:I625 R:R:M699 4.37 3 No Yes 7 7 1 1
R:R:F703 R:R:I625 2.51 3 Yes No 8 7 2 1
R:R:I625 W:W:?1 2.61 3 No Yes 7 0 1 0
R:R:C626 R:R:W674 2.61 3 No Yes 7 9 1 1
R:R:C626 W:W:?1 4.35 3 No Yes 7 0 1 0
R:R:N629 R:R:W674 22.6 3 No Yes 9 9 2 1
R:R:F703 R:R:N629 8.46 3 Yes No 8 9 2 2
R:R:N629 R:R:Y707 5.81 3 No Yes 9 9 2 2
R:R:I630 R:R:W674 3.52 0 No Yes 8 9 2 1
R:R:M677 R:R:W674 4.65 3 No Yes 6 9 1 1
R:R:F703 R:R:W674 8.02 3 Yes Yes 8 9 2 1
R:R:W674 R:R:Y707 10.61 3 Yes Yes 9 9 1 2
R:R:W674 W:W:?1 7.29 3 Yes Yes 9 0 1 0
R:R:I680 R:R:L676 2.85 0 No No 8 7 1 2
R:R:L705 R:R:M677 4.24 0 No No 6 6 2 1
R:R:M677 W:W:?1 5.17 3 No Yes 6 0 1 0
R:R:I680 W:W:?1 6.52 0 No Yes 8 0 1 0
R:R:L681 R:R:R685 12.15 3 No Yes 7 8 1 2
R:R:L681 W:W:?1 11.38 3 No Yes 7 0 1 0
R:R:L688 R:R:Y684 7.03 3 Yes No 6 8 1 1
R:R:H691 R:R:Y684 8.71 3 No No 7 8 2 1
R:R:Y684 W:W:?1 31.07 3 No Yes 8 0 1 0
R:R:I687 R:R:L688 7.14 3 No Yes 6 6 1 1
R:R:I687 W:W:?1 2.61 3 No Yes 6 0 1 0
R:R:H691 R:R:L688 2.57 3 No Yes 7 6 2 1
R:R:L688 W:W:?1 5.06 3 Yes Yes 6 0 1 0
R:R:M699 R:R:Q695 6.8 3 Yes No 7 6 1 2
R:R:M698 W:W:?1 5.17 3 No Yes 8 0 1 0
R:R:M699 W:W:?1 6.46 3 Yes Yes 7 0 1 0
R:R:G702 W:W:?1 4.69 0 No Yes 7 0 1 0
R:R:F703 R:R:Y707 3.09 3 Yes Yes 8 9 2 2
R:R:G702 R:R:V701 1.84 0 No No 7 6 1 2

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

ShowSimilarityNetwork TypeNameLigandDescription
69.23Single8G2YLPC8G2Y-ADGRF1-LPC-chim(Gs-CtGq)/&β;1/&γ;2
56.25Single7WU5K6G7WU5-ADGRF1-K6G-Gi1/&β;1/&γ;2
53.33Single7WU3K6G7WU3-ADGRF1-K6G-Gs/&β;1/&γ;2
29.17Single5KW2PubChem 1330539535KW2-FFA1 (GPR40)-PubChem 133053953
28.57Single5XSZGlyceryl Mono-oleate5XSZ-LPA6-Glyceryl Mono-oleate
20.00Consensusadgrf1_on_alloOther Ligand7WU5-ADGRF1-K6G-Gi1/&β;1/&γ;2 8G2Y-ADGRF1-LPC-chim(Gs-CtGq)/&β;1/&γ;2
16.67Single5TZYMK8666; PubChem 1270535975TZY-FFA1 (GPR40)-MK8666; PubChem 127053597
15.00Single6N48PubChem 1384542566N48-β2-BI167107-PubChem 138454256
11.76Single8U4PCholesterol8U4P-CXCR4-AMD3100-Cholesterol-Gi1/&β;1/&γ;2
10.53Single7CKZMevidalen7CKZ-D1-Dopamine-Mevidalen-Gs/&β;1/&γ;2
10.53Single7LJDMevidalen7LJD-D1-Dopamine-Mevidalen-Gs/&β;1/&γ;1
10.53Single7X2FMevidalen7X2F-D1-Dopamine-Mevidalen-Gs/&β;1/&γ;2
10.53Single8U4QCholesterol8U4Q-CXCR4-REGN7663-Fab-Cholesterol-Gi1/&β;1/&γ;2
10.00Single7LJCMevidalen7LJC-D1-PubChem 86764103-Mevidalen-Gs/&β;1/&γ;2
10.00Single8G94CD698G94-S1P1-CD69-Gi1/&β;1/&γ;2
10.00Consensusd1_on_alloOther Ligand7LJC-D1-PubChem 86764103-Mevidalen-Gs/&β;1/&γ;2 7CKZ-D1-Dopamine-Mevidalen-Gs/&β;1/&γ;2
9.09Single6C1RAvacopan; Na6C1R-C5a1-PMX53-Avacopan; Na
9.09Consensusc5a1_off_ortoalloOther Ligand6C1Q-C5a1-PMX53-NDT9513727 6C1R-C5a1-PMX53-Avacopan; Na
8.00Single7SHEPI; PE7SHE-GPR158-PI; PE
6.90Single7SHEPI; PE7SHE-GPR158-PI; PE
6.90Single7SHFPI; PE7SHF-GPR158-PI; PE-B5; RGS7
6.25Single4PXFOctyl Beta-D-Glucopyranoside4PXF-Rhodopsin-Octyl Beta-D-Glucopyranoside-Arrestin1_Finger_loop
5.88Single8U4NCholesterol8U4N-CXCR4-Cholesterol-Gi1/&β;1/&γ;2
5.56Single6KQIORG275696KQI-CB1-PubMed 104895-ORG27569
5.56Consensuscb1_off_alloOther Ligand6KQI-CB1-PubMed 104895-ORG27569
5.26Single6OBAGTPL110746OBA-β2-(S)-Alprenolol-GTPL11074
5.26Single8U4OCholesterol8U4O-CXCR4-CXCL12-Cholesterol-Gi1/&β;1/&γ;2
5.26Single8U4RCholesterol8U4R-CXCR4-REGN7663-Fab-Cholesterol
5.26Consensusbeta2_off_alloOther Ligand6OBA-β2-(S)-Alprenolol-GTPL11074
4.76Single6C1QNDT95137276C1Q-C5a1-PMX53-NDT9513727
4.55Single5O9HNDT95137275O9H-C5a1-NDT9513727
4.55Single8IYXYL-3658IYX-GPR34-YL-365
3.70Single7SHFPI; PE7SHF-GPR158-PI; PE-B5; RGS7

PDB Summary
PDB 7WU4
Class B2
SubFamily Adhesion
Type Adhesion
SubType ADGRF1
Species Homo sapiens
Ligand -
Other Ligand(s) K6G
Protein Partners Gi1/Beta1/Gamma2
PDB Resolution 3.4
Date 2022-04-27
D.O.I. 10.1038/s41586-022-04580-w
Net Summary
Imin 2.44
Number of Linked Nodes 843
Number of Links 1125
Number of Hubs 210
Number of Links mediated by Hubs 750
Number of Communities 25
Number of Nodes involved in Communities 303
Number of Links involved in Communities 481
Path Summary
Number Of Nodes in MetaPath 105
Number Of Links MetaPath 104
Number of Shortest Paths 4657946
Length Of Smallest Path 3
Average Path Length 33.4247
Length of Longest Path 54
Minimum Path Strength 1.295
Average Path Strength 5.46398
Maximum Path Strength 21.225
Minimum Path Correlation 0.7
Average Path Correlation 0.993946
Maximum Path Correlation 1
Minimum % Of Corr. Nodes 2.77778
Average % Of Corr. Nodes 38.9305
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 58.9585
Maximum Path Hubs % 100
AnnotationTypeLinks
Gene OntologyMolecular Function
Gene OntologyBiological Process
Gene OntologyCellular Component
SCOP2Domain Identifier
SCOP2Family Identifier
Membrane Protein Annotations-• Orientations of Proteins in Membranes database (OPM)   • Protein Data Bank of Transmembrane Proteins (PDBTM)   • MemProtMD


Details about the values in these tables can be found in the corresponding documentation page .
CodeK6G
PDB ResiduesW:W:?1
Environment DetailsOpen EMBL-EBI Page
CodeK6G
Name[(2~{R})-2-oxidanyl-3-[oxidanyl-[2-(trimethyl-$l^{4}-azanyl)ethoxy]phosphoryl]oxy-propyl] hexadecanoate
Synonyms
Identifier[(2~{R})-2-oxidanyl-3-[oxidanyl-[2-(trimethyl-$l^{4}-azanyl)ethoxy]phosphoryl]oxy-propyl] hexadecanoate
FormulaC24 H51 N O7 P
Molecular Weight496.638
SMILESCCCCCCCCCCCCCCCC(=O)OC[C@H](COP(=O)(O)OCC[N](C)(C)C)O
PubChem
Formal Charge0
Total Atoms84
Total Chiral Atoms1
Total Bonds83
Total Aromatic Bonds0

PDBsumOpen PDBsum Page
ChainA
ProteinG Protein α Sub unit
UniProtP63096
Sequence
>7WU4_Chain_A
KAAVERSKM IDRNLREDG EKAAREVKL LLLGADNSG KSTIVKQMT 
GIVETHFTF KDLHFKMFD VGGQRSERK KWIHCFEDV AAIIFCVDL 
SDYNRMHES MKLFDSICN NKWFTDTSI ILFLNKKDL FEEKIKKSP 
LTICYQEYA GSNTYEEAA AYIQCQFED LNKRKDTKE IYTHFTCAT 
DTKNAQFIF DAVTDVIIK NNLKDCGLF


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainB
ProteinG Protein β Sub unit
UniProtP62873
Sequence
>7WU4_Chain_B
SELDQLRQE AEQLKNQIR DARKACADA TLSQITNNI DPVGRIQMR 
TRRTLRGHL AKIYAMHWG TDSRLLVSA SQDGKLIIW DSYTTNKVH 
AIPLRSSWV MTCAYAPSG NYVACGGLD NICSIYNLK TREGNVRVS 
RELAGHTGY LSCCRFLDD NQIVTSSGD TTCALWDIE TGQQTTTFT 
GHTGDVMSL SLAPDTRLF VSGACDASA KLWDVREGM CRQTFTGHE 
SDINAICFF PNGNAFATG SDDATCRLF DLRADQELM TYSHDNIIC 
GITSVSFSK SGRLLLAGY DDFNCNVWD ALKADRAGV LAGHDNRVS 
CLGVTDDGM AVATGSWDS FLKIWN


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainG
ProteinG Protein γ Sub unit
UniProtP59768
Sequence
>7WU4_Chain_G
ASIAQARKL VEQLKMEAN IDRIKVSKA AADLMAYCE AHAKEDPLL 
TPVPASENP FR


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainR
ProteinReceptor
UniProtQ5T601
Sequence
>7WU4_Chain_R
TSFSILMSP FVPSTIFPV VKWITYVGL GISIGSLIL CLIIEALFW 
KQIKKSQTS HTRRICMVN IALSLLIAD VWFIVGATV DTTVNPSGV 
CTAAVFFTH FFYLSLFFW MLMLGILLA YRIILVFHH MAQHLMMAV 
GFCLGYGCP LIISVITIA VTQPSNTYK RKDVCWLNW SNGSKPLLA 
FVVPALAIV AVNFVVVLL VLTKLWRPT VGERLSRDD KATIIRVGK 
SLLILTPLL GLTWGFGIG TIVDSQNLA WHVIFALLN AFQGFFILC 
FGILLDSKL RQLLFNK


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  




This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
7WU3B2AdhesionAdhesionADGRF1Homo sapiens-K6GGs/&β;1/&γ;23.12022-04-2710.1038/s41586-022-04580-w
7WU4B2AdhesionAdhesionADGRF1Homo sapiens-K6GGi1/&β;1/&γ;23.42022-04-2710.1038/s41586-022-04580-w
7WU5B2AdhesionAdhesionADGRF1Homo sapiens-K6GGi1/&β;1/&γ;232022-04-2710.1038/s41586-022-04580-w
7WXUB2AdhesionAdhesionADGRF1Homo sapiens--chim(NtGi1-Gs-CtGq)/&β;1/&γ;22.852022-09-2810.1038/s41467-022-33173-4
7WXWB2AdhesionAdhesionADGRF1Homo sapiens--chim(NtGi1-Gs)/&β;1/&γ;22.842022-09-2810.1038/s41467-022-33173-4
7WY0B2AdhesionAdhesionADGRF1Homo sapiens--chim(NtGi1L-G13)/&β;1/&γ;22.832022-09-2810.1038/s41467-022-33173-4
7WZ7B2AdhesionAdhesionADGRF1Homo sapiens--chim(NtGi1-G12)/&β;1/&γ;22.832022-09-2810.1038/s41467-022-33173-4
7X2VB2AdhesionAdhesionADGRF1Homo sapiens--Gi1/&β;1/&γ;23.092022-09-2810.1038/s41467-022-33173-4
8G2YB2AdhesionAdhesionADGRF1Homo sapiens-LPCchim(Gs-CtGq)/&β;1/&γ;23.442023-05-1010.1038/s41467-023-38083-7




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