psnGPCR

Press and hold down the left mouse button and move the mouse to rotate.
Press and hold down the central mouse button and move the mouse to translate.
Use the mouse wheel to zoom in or out.
Click on any atom on your molecule and the corresponding residue label will be placed beneath the viewer.

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:P5	R:R:Q6	7.9	No	No	0	7	4
2	R:R:P5	R:R:S69	3.56	No	No	0	7	4
3	R:R:F9	R:R:V13	6.55	No	No	0	6	6
4	R:R:F9	R:R:L67	19.49	No	No	0	6	4
5	R:R:K62	R:R:Y12	16.72	No	Yes	0	7	9
6	R:R:L262	R:R:Y12	3.52	No	Yes	0	5	9
7	R:R:I263	R:R:Y12	8.46	No	Yes	0	6	9
8	R:R:A15	R:R:W267	6.48	No	No	0	7	4
9	R:R:F16	R:R:T56	3.89	No	No	0	6	6
10	R:R:F16	R:R:L59	3.65	No	No	0	6	9
11	R:R:F16	R:R:P60	7.22	No	No	0	6	9
12	R:R:L18	R:R:V270	4.47	No	No	0	6	6
13	R:R:G19	R:R:V269	3.68	No	Yes	0	8	7
14	R:R:F20	R:R:P21	4.33	No	No	0	5	5
15	R:R:F20	R:R:V24	3.93	No	No	0	5	3
16	R:R:D52	R:R:N23	13.46	Yes	No	0	9	9
17	R:R:N23	R:R:P273	13.03	No	No	0	9	9
18	R:R:G49	R:R:I27	3.53	No	Yes	0	8	7
19	R:R:P40	R:R:T39	3.5	Yes	No	0	7	7
20	R:R:P40	R:R:Y114	5.56	Yes	Yes	2	7	6
21	R:R:P40	R:R:R118	5.76	Yes	No	2	7	8
22	R:R:P40	R:R:S123	3.56	Yes	Yes	2	7	8
23	R:R:P40	W:W:?1	5.47	Yes	Yes	2	7	0
24	R:R:R104	R:R:S41	9.22	No	No	0	9	7
25	R:R:S123	R:R:V43	4.85	Yes	No	0	8	7
26	R:R:V43	R:R:W124	17.16	No	No	0	7	4
27	R:R:A99	R:R:Y44	8.01	No	Yes	2	6	7
28	R:R:L100	R:R:Y44	3.52	No	Yes	0	8	7
29	R:R:S123	R:R:Y44	7.63	Yes	Yes	2	8	7
30	R:R:V126	R:R:Y44	8.83	No	Yes	2	5	7
31	R:R:Y44	W:W:?1	10.93	Yes	Yes	2	7	0
32	R:R:A45	R:R:T276	5.03	No	No	0	7	7
33	R:R:F96	R:R:N47	9.67	Yes	No	3	6	9
34	R:R:C127	R:R:N47	12.6	No	No	3	7	9
35	R:R:D52	R:R:L48	4.07	Yes	Yes	3	9	9
36	R:R:F96	R:R:L48	4.87	Yes	Yes	3	6	9
37	R:R:L48	R:R:L97	5.54	Yes	Yes	3	9	8
38	R:R:L48	R:R:N272	9.61	Yes	Yes	3	9	9
39	R:R:F96	R:R:S51	5.28	Yes	No	0	6	8
40	R:R:D52	R:R:V269	4.38	Yes	Yes	0	9	7
41	R:R:D52	R:R:N272	10.77	Yes	Yes	3	9	9
42	R:R:H86	R:R:L55	5.14	Yes	Yes	0	6	7
43	R:R:L55	R:R:P89	4.93	Yes	No	0	7	8
44	R:R:L55	R:R:L90	4.15	Yes	No	0	7	7
45	R:R:L55	R:R:V269	4.47	Yes	Yes	0	7	7
46	R:R:T56	R:R:V269	4.76	No	Yes	0	6	7
47	R:R:F82	R:R:S58	3.96	Yes	No	0	5	7
48	R:R:H86	R:R:S58	8.37	Yes	No	0	6	7
49	R:R:L61	R:R:W72	6.83	No	Yes	1	6	9
50	R:R:F82	R:R:L61	12.18	Yes	No	1	5	6
51	R:R:E65	R:R:K62	9.45	No	No	0	7	7
52	R:R:H86	R:R:K62	6.55	Yes	No	0	6	7
53	R:R:E65	R:R:L171	5.3	No	Yes	0	7	5
54	R:R:E172	R:R:E65	5.07	Yes	No	0	6	7
55	R:R:E172	R:R:G70	6.55	Yes	No	0	6	6
56	R:R:P73	R:R:W72	6.76	No	Yes	1	4	9
57	R:R:L74	R:R:W72	10.25	No	Yes	1	7	9
58	R:R:C79	R:R:W72	6.53	No	Yes	1	9	9
59	R:R:F82	R:R:W72	10.02	Yes	Yes	1	5	9
60	R:R:C170	R:R:W72	10.45	No	Yes	1	9	9
61	R:R:L74	R:R:P73	4.93	No	No	1	7	4
62	R:R:L74	R:R:L78	5.54	No	No	0	7	5
63	R:R:L78	R:R:P75	4.93	No	No	0	5	8
64	R:R:C79	R:R:P80	3.77	No	No	0	9	7
65	R:R:C170	R:R:C79	7.28	No	No	1	9	9
66	R:R:A146	R:R:P80	3.74	No	No	0	3	7
67	R:R:F82	R:R:L171	3.65	Yes	Yes	1	5	5
68	R:R:A83	R:R:F142	5.55	No	No	0	6	4
69	R:R:F87	R:R:H86	4.53	Yes	Yes	1	6	6
70	R:R:H86	R:R:L171	3.86	Yes	Yes	1	6	5
71	R:R:F87	R:R:Y91	4.13	Yes	Yes	0	6	8
72	R:R:F87	R:R:L171	3.65	Yes	Yes	1	6	5
73	R:R:F87	R:R:Y240	9.28	Yes	Yes	1	6	8
74	R:R:L138	R:R:Y91	5.86	No	Yes	0	6	8
75	R:R:L190	R:R:Y91	5.86	No	Yes	0	6	8
76	R:R:N241	R:R:Y91	10.47	No	Yes	0	9	8
77	R:R:A92	R:R:F96	4.16	No	Yes	3	6	6
78	R:R:A92	R:R:W131	3.89	No	No	3	6	9
79	R:R:G95	W:W:?1	5.69	No	Yes	0	5	0
80	R:R:C127	R:R:F96	4.19	No	Yes	3	7	6
81	R:R:F96	R:R:I130	7.54	Yes	No	0	6	6
82	R:R:F96	R:R:W131	11.02	Yes	No	3	6	9
83	R:R:L97	R:R:N272	10.98	Yes	Yes	3	8	9
84	R:R:A99	W:W:?1	5.24	No	Yes	2	6	0
85	R:R:S101	R:R:T198	6.4	No	No	0	9	8
86	R:R:C201	R:R:S101	5.16	No	No	0	7	9
87	R:R:A102	W:W:?1	8.39	No	Yes	0	6	0
88	R:R:R104	R:R:V225	9.15	No	No	0	9	7
89	R:R:L106	R:R:Y105	3.52	No	Yes	2	7	7
90	R:R:A109	R:R:Y105	5.34	No	Yes	2	8	7
91	R:R:F110	R:R:Y105	4.13	No	Yes	2	6	7
92	R:R:F200	R:R:Y105	4.13	No	Yes	0	4	7
93	R:R:C201	R:R:Y105	6.72	No	Yes	0	7	7
94	R:R:G204	R:R:Y105	4.35	No	Yes	0	4	7
95	R:R:L106	R:R:Y114	9.38	No	Yes	2	7	6
96	R:R:L106	W:W:?1	3.69	No	Yes	2	7	0
97	R:R:G107	R:R:Y114	4.35	No	Yes	0	8	6
98	R:R:A109	R:R:F110	5.55	No	No	2	8	6
99	R:R:R118	R:R:Y114	10.29	No	Yes	2	8	6
100	R:R:Y114	W:W:?1	7.02	Yes	Yes	2	6	0
101	R:R:Q115	R:R:R118	5.84	No	No	0	5	8
102	R:R:Q115	R:R:R218	5.84	No	No	0	5	5
103	R:R:R119	R:R:Y122	8.23	No	No	0	5	3
104	R:R:S123	W:W:?1	4	Yes	Yes	2	8	0
105	R:R:V126	W:W:?1	8.93	No	Yes	2	5	0
106	R:R:I130	W:W:?1	6.65	No	Yes	0	6	0
107	R:R:L133	W:W:?1	3.69	No	Yes	0	5	0
108	R:R:H137	R:R:S185	6.97	Yes	No	0	5	5
109	R:R:H137	R:R:L186	10.29	Yes	No	0	5	6
110	R:R:H137	R:R:L189	6.43	Yes	No	0	5	5
111	R:R:H137	R:R:L190	10.29	Yes	No	0	5	6
112	R:R:L138	R:R:L186	5.54	No	No	0	6	6
113	R:R:L186	R:R:V141	11.92	No	No	0	6	5
114	R:R:F142	R:R:R183	11.76	No	No	0	4	6
115	R:R:E172	R:R:K259	8.1	Yes	No	0	6	3
116	R:R:S247	R:R:W174	3.71	No	Yes	0	6	4
117	R:R:L253	R:R:W174	4.56	No	Yes	0	3	4
118	R:R:G255	R:R:W174	4.22	No	Yes	0	5	4
119	R:R:R258	R:R:W174	5	Yes	Yes	0	7	4
120	R:R:D175	R:R:R183	21.44	Yes	No	1	6	6
121	R:R:D175	R:R:N244	4.04	Yes	No	1	6	7
122	R:R:D175	R:R:F248	4.78	Yes	Yes	1	6	5
123	R:R:P176	R:R:S178	3.56	No	No	0	1	1
124	R:R:A179	R:R:P176	3.74	No	No	0	4	1
125	R:R:G180	R:R:P181	4.06	No	No	0	3	4
126	R:R:F248	R:R:G180	10.54	Yes	No	0	5	3
127	R:R:F248	R:R:R183	4.28	Yes	No	1	5	6
128	R:R:F184	R:R:L188	4.87	No	No	0	4	4
129	R:R:F184	R:R:V245	5.24	No	No	0	4	5
130	R:R:N241	R:R:S187	8.94	No	No	0	9	5
131	R:R:F191	R:R:F192	11.79	Yes	No	0	9	4
132	R:R:F191	R:R:L195	7.31	Yes	No	0	9	6
133	R:R:F191	R:R:V237	5.24	Yes	No	0	9	8
134	R:R:F191	R:R:G238	4.52	Yes	No	0	9	4
135	R:R:F191	R:R:N241	13.29	Yes	No	0	9	9
136	R:R:L193	W:W:?1	6.45	No	Yes	0	4	0
137	R:R:P194	W:W:?1	14.21	No	Yes	0	9	0
138	R:R:I197	W:W:?1	4.75	No	Yes	0	6	0
139	R:R:L233	R:R:T198	4.42	No	No	0	9	8
140	R:R:F202	R:R:L206	10.96	Yes	No	0	8	5
141	R:R:F202	R:R:G227	6.02	Yes	No	0	8	4
142	R:R:F202	R:R:L230	4.87	Yes	No	0	8	8
143	R:R:R207	R:R:R211	4.26	No	No	0	4	4
144	R:R:H216	R:R:L209	3.86	No	No	0	2	8
145	R:R:L209	R:R:L220	4.15	No	No	0	8	4
146	R:R:L214	R:R:S212	12.01	No	No	0	3	5
147	R:R:L220	R:R:W224	4.56	No	No	0	4	5
148	R:R:G228	R:R:V275	3.68	No	No	0	5	7
149	R:R:L271	R:R:T232	7.37	No	No	0	6	6
150	R:R:L233	R:R:V237	4.47	No	No	0	9	8
151	R:R:C236	R:R:L271	4.76	No	No	0	8	6
152	R:R:G238	R:R:P239	4.06	No	No	0	4	9
153	R:R:P239	R:R:T264	6.99	No	No	0	9	5
154	R:R:N244	R:R:Y240	13.96	No	Yes	1	7	8
155	R:R:R258	R:R:Y240	8.23	Yes	Yes	1	7	8
156	R:R:L262	R:R:Y240	7.03	No	Yes	0	5	8
157	R:R:R258	R:R:S243	3.95	Yes	No	0	7	5
158	R:R:N244	R:R:R258	7.23	No	Yes	1	7	7
159	R:R:F248	R:R:S247	7.93	Yes	No	0	5	6
160	R:R:L249	R:R:Y250	4.69	No	No	0	4	2
161	R:R:N252	R:R:Y250	4.65	No	No	0	1	2
162	R:R:V270	R:R:W267	8.58	No	No	0	6	4
163	R:R:N272	R:R:S268	5.96	Yes	No	0	9	9
164	R:R:T276	R:R:Y278	7.49	No	No	0	7	7
165	R:R:C236	R:R:S268	3.44	No	No	0	8	9
166	R:R:L46	R:R:W124	3.42	No	No	0	6	4
167	R:R:G94	R:R:L97	3.42	No	Yes	0	8	8
168	R:R:A182	R:R:V141	3.39	No	No	0	4	5
169	R:R:A173	R:R:V169	3.39	No	No	0	5	5
170	R:R:L3	R:R:P4	3.28	No	No	0	7	6
171	R:R:L7	R:R:P4	3.28	No	No	0	7	6
172	R:R:L54	R:R:P89	3.28	No	No	0	7	8
173	R:R:L214	R:R:P111	3.28	No	No	0	3	9
174	R:R:D175	R:R:P176	3.22	Yes	No	0	6	1
175	R:R:R217	R:R:R221	3.2	No	No	0	3	7
176	R:R:T232	R:R:V275	3.17	No	No	0	6	7
177	R:R:A30	R:R:L46	3.15	No	No	0	6	6
178	R:R:A266	R:R:L59	3.15	No	No	0	6	9
179	R:R:A88	R:R:L135	3.15	No	No	0	5	3
180	R:R:A229	R:R:L97	3.15	No	Yes	0	8	8
181	R:R:A103	W:W:?1	3.15	No	Yes	0	8	0
182	R:R:Y122	W:W:?1	3.12	No	Yes	0	3	0
183	R:R:I263	R:R:S8	3.1	No	No	0	6	3
184	R:R:K219	R:R:S212	3.06	No	No	0	6	5
185	R:R:A179	R:R:E145	3.02	No	No	0	4	4
186	R:R:L100	R:R:S41	3	No	No	0	8	7
187	R:R:L230	R:R:T198	2.95	No	No	0	8	8
188	R:R:L260	R:R:T264	2.95	No	No	0	3	5
189	R:R:G29	R:R:Y278	2.9	No	No	0	7	7
190	R:R:I263	R:R:L11	2.85	No	No	0	6	5
191	R:R:I27	R:R:L53	2.85	Yes	No	0	7	7
192	R:R:K219	R:R:L209	2.82	No	No	0	6	8
193	R:R:G254	R:R:W257	2.81	No	No	0	6	5
194	R:R:A63	R:R:F9	2.77	No	No	0	7	6
195	R:R:A222	R:R:R104	2.77	No	No	0	8	9
196	R:R:L195	R:R:L234	2.77	No	No	0	6	5
197	R:R:A226	R:R:F202	2.77	No	Yes	0	7	8
198	R:R:L231	R:R:L235	2.77	No	No	0	5	5
199	R:R:L53	R:R:N23	2.75	No	No	0	7	9
200	R:R:A66	R:R:Y12	2.67	No	Yes	0	6	9
201	R:R:R207	R:R:V203	2.62	No	No	0	4	3
202	R:R:A14	R:R:W267	2.59	No	No	0	4	4
203	R:R:F20	R:R:T56	2.59	No	No	0	5	6
204	R:R:R218	R:R:T215	2.59	No	No	0	5	3
205	R:R:V134	R:R:Y91	2.52	No	Yes	0	7	8
206	R:R:S256	R:R:W257	2.47	No	No	0	1	5
207	R:R:L253	R:R:W257	2.28	No	No	0	3	5
208	R:R:G93	R:R:G94	2.11	No	No	0	9	8
209	R:R:A129	W:W:?1	2.1	No	Yes	0	3	0
210	R:R:G261	R:R:P239	2.03	No	No	0	6	9
211	R:R:C236	R:R:G265	1.96	No	No	0	8	8
212	R:R:P4	R:R:P5	1.95	No	No	0	6	7
213	R:R:A98	R:R:G95	1.95	No	No	0	7	5
214	R:R:A128	R:R:G125	1.95	No	No	0	4	1
215	R:R:A26	R:R:P273	1.87	No	No	0	9	9
216	R:R:A88	R:R:P89	1.87	No	No	0	5	8
217	R:R:G10	R:R:V13	1.84	No	No	0	5	6
218	R:R:G139	R:R:V84	1.84	No	No	0	4	6
219	R:R:G277	R:R:T276	1.82	No	No	0	4	7
220	R:R:A108	R:R:C205	1.81	No	Yes	0	8	7
221	R:R:A222	R:R:C205	1.81	No	Yes	0	8	7
222	R:R:A223	R:R:C205	1.81	No	Yes	0	5	7
223	R:R:A226	R:R:C205	1.81	No	Yes	0	7	7
224	R:R:A30	R:R:A45	1.79	No	No	0	6	7
225	R:R:A68	R:R:A71	1.79	No	No	0	3	4
226	R:R:A108	R:R:A208	1.79	No	No	0	8	5
227	R:R:A109	R:R:A208	1.79	No	No	0	8	5
228	R:R:P73	R:R:V64	1.77	No	No	0	4	4
229	R:R:G19	R:R:L18	1.71	No	No	0	8	6
230	R:R:G139	R:R:L138	1.71	No	No	0	4	6
231	R:R:A42	R:R:T39	1.68	No	No	0	7	7
232	R:R:L22	R:R:P273	1.64	No	No	0	7	9
233	R:R:C50	R:R:I27	1.64	No	Yes	0	4	7
234	R:R:L112	R:R:P111	1.64	No	No	0	6	9
235	R:R:N252	R:R:P251	1.63	No	No	0	1	2
236	R:R:F117	W:W:?1	1.62	No	Yes	0	4	0
237	R:R:A108	R:R:K219	1.61	No	No	0	8	6
238	R:R:A199	R:R:L230	1.58	No	No	0	4	8
239	R:R:I27	R:R:T31	1.52	Yes	No	0	7	1
240	R:R:L78	R:R:S77	1.5	No	No	0	5	1
241	R:R:G204	R:R:R207	1.5	No	No	0	4	4
242	R:R:P120	R:R:R119	1.44	No	No	0	4	5
243	R:R:E172	R:R:V169	1.43	Yes	No	0	6	5
244	R:R:C121	R:R:R119	1.39	No	No	0	4	5
245	R:R:L11	R:R:L7	1.38	No	No	0	5	7
246	R:R:L188	R:R:L189	1.38	No	No	0	4	5
247	R:R:A63	R:R:Y12	1.33	No	Yes	0	7	9
248	R:R:R217	R:R:T215	1.29	No	No	0	3	3

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	R:R:Y12	6.54	5	0	9
2	R:R:I27	2.385	4	0	7
3	R:R:P40	4.77	5	2	7
4	R:R:Y44	7.784	5	2	7
5	R:R:L48	6.0225	4	3	9
6	R:R:D52	8.17	4	3	9
7	R:R:L55	4.6725	4	0	7
8	R:R:W72	8.47333	6	1	9
9	R:R:F82	7.4525	4	1	5
10	R:R:H86	5.69	5	1	6
11	R:R:F87	5.3975	4	1	6
12	R:R:Y91	5.768	5	0	8
13	R:R:F96	6.67571	7	3	6
14	R:R:L97	5.7725	4	3	8
15	R:R:Y105	4.69833	6	2	7
16	R:R:Y114	7.32	5	2	6
17	R:R:S123	5.01	4	2	8
18	R:R:H137	8.495	4	0	5
19	R:R:L171	4.115	4	1	5
20	R:R:E172	5.2875	4	0	6
21	R:R:W174	4.3725	4	0	4
22	R:R:D175	8.37	4	1	6
23	R:R:F191	8.43	5	0	9
24	R:R:F202	6.155	4	0	8
25	R:R:C205	1.81	4	0	7
26	R:R:Y240	9.625	4	1	8
27	R:R:F248	6.8825	4	1	5
28	R:R:R258	6.1025	4	1	7
29	R:R:V269	4.3225	4	0	7
30	R:R:N272	9.33	4	3	9
31	W:W:?1	5.83889	18	2	0

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:A63	R:R:F9	10.9032	2.77	No	No	0	7	6
2	R:R:A63	R:R:Y12	13.5875	1.33	No	Yes	0	7	9
3	R:R:I263	R:R:Y12	23.8087	8.46	No	Yes	0	6	9
4	R:R:I263	R:R:L11	18.8861	2.85	No	No	0	6	5
5	R:R:L11	R:R:L7	16.2543	1.38	No	No	0	5	7
6	R:R:L7	R:R:P4	13.5875	3.28	No	No	0	7	6
7	R:R:K62	R:R:Y12	31.9402	16.72	No	Yes	0	7	9
8	R:R:L262	R:R:Y12	10.9994	3.52	No	Yes	0	5	9
9	R:R:G19	R:R:L18	10.7458	1.71	No	No	0	8	6
10	R:R:G19	R:R:V269	12.8443	3.68	No	Yes	0	8	7
11	R:R:L55	R:R:V269	100	4.47	Yes	Yes	0	7	7
12	R:R:H86	R:R:L55	99.8426	5.14	Yes	Yes	0	6	7
13	R:R:H86	R:R:K62	36.3907	6.55	Yes	No	0	6	7
14	R:R:T56	R:R:V269	16.6477	4.76	No	Yes	0	6	7
15	R:R:D52	R:R:V269	98.4524	4.38	Yes	Yes	0	9	7
16	R:R:D52	R:R:N23	18.956	13.46	Yes	No	0	9	9
17	R:R:L53	R:R:N23	10.7021	2.75	No	No	0	7	9
18	R:R:P40	W:W:?1	13.7973	5.47	Yes	Yes	2	7	0
19	R:R:I130	W:W:?1	81.8396	6.65	No	Yes	0	6	0
20	R:R:F96	R:R:I130	82.3205	7.54	Yes	No	0	6	6
21	R:R:F96	R:R:L48	85.783	4.87	Yes	Yes	3	6	9
22	R:R:D52	R:R:L48	81.4899	4.07	Yes	Yes	3	9	9
23	R:R:Y114	W:W:?1	11.218	7.02	Yes	Yes	2	6	0
24	R:R:R118	R:R:Y114	11.83	10.29	No	Yes	2	8	6
25	R:R:S123	W:W:?1	17.8281	4	Yes	Yes	2	8	0
26	R:R:Y44	W:W:?1	10.3261	10.93	Yes	Yes	2	7	0
27	R:R:L100	R:R:Y44	10.2474	3.52	No	Yes	0	8	7
28	R:R:S123	R:R:V43	18.3789	4.85	Yes	No	0	8	7
29	R:R:V43	R:R:W124	16.4991	17.16	No	No	0	7	4
30	R:R:A30	R:R:A45	10.4398	1.79	No	No	0	6	7
31	R:R:A30	R:R:L46	12.477	3.15	No	No	0	6	6
32	R:R:L46	R:R:W124	14.4968	3.42	No	No	0	6	4
33	R:R:D52	R:R:N272	14.8553	10.77	Yes	Yes	3	9	9
34	R:R:F82	R:R:S58	14.6367	3.96	Yes	No	0	5	7
35	R:R:H86	R:R:S58	16.5341	8.37	Yes	No	0	6	7
36	R:R:F82	R:R:L171	25.8722	3.65	Yes	Yes	1	5	5
37	R:R:H86	R:R:L171	21.2381	3.86	Yes	Yes	1	6	5
38	R:R:E65	R:R:L171	12.5033	5.3	No	Yes	0	7	5
39	R:R:F82	R:R:W72	35.0616	10.02	Yes	Yes	1	5	9
40	R:R:E172	R:R:E65	14.5318	5.07	Yes	No	0	6	7
41	R:R:L74	R:R:W72	13.2465	10.25	No	Yes	1	7	9
42	R:R:L74	R:R:L78	10.0114	5.54	No	No	0	7	5
43	R:R:D175	R:R:N244	19.5156	4.04	Yes	No	1	6	7
44	R:R:N244	R:R:Y240	20.5911	13.96	No	Yes	1	7	8
45	R:R:L262	R:R:Y240	11.83	7.03	No	Yes	0	5	8
46	R:R:F87	R:R:H86	50.118	4.53	Yes	Yes	1	6	6
47	R:R:F87	R:R:Y240	42.686	9.28	Yes	Yes	1	6	8
48	R:R:F87	R:R:Y91	57.4714	4.13	Yes	Yes	0	6	8
49	R:R:L138	R:R:Y91	11.8213	5.86	No	Yes	0	6	8
50	R:R:L190	R:R:Y91	14.287	5.86	No	Yes	0	6	8
51	R:R:N241	R:R:Y91	41.7242	10.47	No	Yes	0	9	8
52	R:R:F191	R:R:N241	40.8062	13.29	Yes	No	0	9	9
53	R:R:F191	R:R:V237	35.4464	5.24	Yes	No	0	9	8
54	R:R:L233	R:R:V237	34.8605	4.47	No	No	0	9	8
55	R:R:L233	R:R:T198	34.4496	4.42	No	No	0	9	8
56	R:R:S101	R:R:T198	18.0205	6.4	No	No	0	9	8
57	R:R:C201	R:R:S101	17.8893	5.16	No	No	0	7	9
58	R:R:L106	W:W:?1	31.1533	3.69	No	Yes	2	7	0
59	R:R:L106	R:R:Y105	35.5863	3.52	No	Yes	2	7	7
60	R:R:A109	R:R:Y105	17.0237	5.34	No	Yes	2	8	7
61	R:R:Q115	R:R:R118	17.8543	5.84	No	No	0	5	8
62	R:R:Q115	R:R:R218	14.1733	5.84	No	No	0	5	5
63	R:R:H137	R:R:L190	12.2235	10.29	Yes	No	0	5	6
64	R:R:R258	R:R:Y240	15.2313	8.23	Yes	Yes	1	7	8
65	R:R:R258	R:R:W174	12.2847	5	Yes	Yes	0	7	4
66	R:R:F202	R:R:L230	20.1889	4.87	Yes	No	0	8	8
67	R:R:L230	R:R:T198	23.5114	2.95	No	No	0	8	8
68	R:R:A108	R:R:K219	19.4282	1.61	No	No	0	8	6
69	R:R:A108	R:R:C205	13.0366	1.81	No	Yes	0	8	7
70	R:R:A226	R:R:C205	15.7821	1.81	No	Yes	0	7	7
71	R:R:A226	R:R:F202	15.5198	2.77	No	Yes	0	7	8
72	R:R:A108	R:R:A208	13.4476	1.79	No	No	0	8	5
73	R:R:A109	R:R:A208	15.31	1.79	No	No	0	8	5
74	R:R:C236	R:R:S268	12.6344	3.44	No	No	0	8	9
75	R:R:N272	R:R:S268	14.6804	5.96	Yes	No	0	9	9
76	R:R:R218	R:R:T215	11.1917	2.59	No	No	0	5	3
77	R:R:F87	R:R:L171	13.2902	3.65	Yes	Yes	1	6	5
78	R:R:C201	R:R:Y105	17.8106	6.72	No	Yes	0	7	7

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:P40	R:R:T39	3.5	2	Yes	No	7	7	1	2
R:R:P40	R:R:Y114	5.56	2	Yes	Yes	7	6	1	1
R:R:P40	R:R:R118	5.76	2	Yes	No	7	8	1	2
R:R:P40	R:R:S123	3.56	2	Yes	Yes	7	8	1	1
R:R:P40	W:W:?1	5.47	2	Yes	Yes	7	0	1	0
R:R:S123	R:R:V43	4.85	2	Yes	No	8	7	1	2
R:R:A99	R:R:Y44	8.01	2	No	Yes	6	7	1	1
R:R:L100	R:R:Y44	3.52	0	No	Yes	8	7	2	1
R:R:S123	R:R:Y44	7.63	2	Yes	Yes	8	7	1	1
R:R:V126	R:R:Y44	8.83	2	No	Yes	5	7	1	1
R:R:Y44	W:W:?1	10.93	2	Yes	Yes	7	0	1	0
R:R:G95	W:W:?1	5.69	0	No	Yes	5	0	1	0
R:R:F96	R:R:I130	7.54	3	Yes	No	6	6	2	1
R:R:A99	W:W:?1	5.24	2	No	Yes	6	0	1	0
R:R:A102	W:W:?1	8.39	0	No	Yes	6	0	1	0
R:R:L106	R:R:Y105	3.52	2	No	Yes	7	7	1	2
R:R:L106	R:R:Y114	9.38	2	No	Yes	7	6	1	1
R:R:L106	W:W:?1	3.69	2	No	Yes	7	0	1	0
R:R:G107	R:R:Y114	4.35	0	No	Yes	8	6	2	1
R:R:R118	R:R:Y114	10.29	2	No	Yes	8	6	2	1
R:R:Y114	W:W:?1	7.02	2	Yes	Yes	6	0	1	0
R:R:R119	R:R:Y122	8.23	0	No	No	5	3	2	1
R:R:S123	W:W:?1	4	2	Yes	Yes	8	0	1	0
R:R:V126	W:W:?1	8.93	2	No	Yes	5	0	1	0
R:R:I130	W:W:?1	6.65	0	No	Yes	6	0	1	0
R:R:L133	W:W:?1	3.69	0	No	Yes	5	0	1	0
R:R:L193	W:W:?1	6.45	0	No	Yes	4	0	1	0
R:R:P194	W:W:?1	14.21	0	No	Yes	9	0	1	0
R:R:I197	W:W:?1	4.75	0	No	Yes	6	0	1	0
R:R:A103	W:W:?1	3.15	0	No	Yes	8	0	1	0
R:R:Y122	W:W:?1	3.12	0	No	Yes	3	0	1	0
R:R:A129	W:W:?1	2.1	0	No	Yes	3	0	1	0
R:R:A98	R:R:G95	1.95	0	No	No	7	5	2	1
R:R:F117	W:W:?1	1.62	0	No	Yes	4	0	1	0

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

Similarity	Network Type	Name	Ligand	Description
57.14	Single	5TZY	MK8666; PubChem 127053597	5TZY-FFA1 (GPR40)-MK8666; PubChem 127053597
40.00	Single	5O9H	NDT9513727	5O9H-C5a₁-NDT9513727
39.13	Single	7SHE	PI; PE	7SHE-GPR158-PI; PE
38.46	Single	7SHE	PI; PE	7SHE-GPR158-PI; PE
38.46	Single	7SHF	PI; PE	7SHF-GPR158-PI; PE-B5; RGS7
33.33	Single	6N48	PubChem 138454256	6N48-β₂-BI167107-PubChem 138454256
33.33	Single	7WU3	K6G	7WU3-ADGRF1-K6G-Gs/&β;1/&γ;2
32.00	Single	7SHF	PI; PE	7SHF-GPR158-PI; PE-B5; RGS7
31.82	Single	6C1R	Avacopan; Na	6C1R-C5a₁-PMX53-Avacopan; Na
31.82	Consensus	c5a1_off_ortoallo	Other Ligand	6C1Q-C5a₁-PMX53-NDT9513727 6C1R-C5a₁-PMX53-Avacopan; Na
30.00	Single	7CKZ	Mevidalen	7CKZ-D₁-Dopamine-Mevidalen-Gs/&β;1/&γ;2
29.17	Single	7WU4	K6G	7WU4-ADGRF1-K6G-Gi1/&β;1/&γ;2
28.57	Single	6C1Q	NDT9513727	6C1Q-C5a₁-PMX53-NDT9513727
28.57	Single	8G2Y	LPC	8G2Y-ADGRF1-LPC-chim(Gs-CtGq)/&β;1/&γ;2
28.57	Consensus	d1_on_allo	Other Ligand	7LJC-D₁-PubChem 86764103-Mevidalen-Gs/&β;1/&γ;2 7CKZ-D₁-Dopamine-Mevidalen-Gs/&β;1/&γ;2
27.78	Single	5XSZ	Glyceryl Mono-oleate	5XSZ-LPA₆-Glyceryl Mono-oleate
25.00	Single	6OBA	GTPL11074	6OBA-β₂-(S)-Alprenolol-GTPL11074
25.00	Consensus	beta2_off_allo	Other Ligand	6OBA-β₂-(S)-Alprenolol-GTPL11074
20.00	Single	7WU5	K6G	7WU5-ADGRF1-K6G-Gi1/&β;1/&γ;2
18.18	Single	7LJD	Mevidalen	7LJD-D₁-Dopamine-Mevidalen-Gs/&β;1/&γ;1
18.18	Single	7X2F	Mevidalen	7X2F-D₁-Dopamine-Mevidalen-Gs/&β;1/&γ;2
17.39	Single	7LJC	Mevidalen	7LJC-D₁-PubChem 86764103-Mevidalen-Gs/&β;1/&γ;2
16.67	Single	8IYX	YL-365	8IYX-GPR34-YL-365
16.00	Consensus	adgrf1_on_allo	Other Ligand	7WU5-ADGRF1-K6G-Gi1/&β;1/&γ;2 8G2Y-ADGRF1-LPC-chim(Gs-CtGq)/&β;1/&γ;2
8.70	Single	8WG8	Peptide	8WG8-Glucagon-Peptide-chim(NtGi1-Gs)/&β;1/&γ;2
8.00	Single	8U8F	PML	8U8F-GPR3-PML-Gs/&β;1/&γ;2
6.25	Single	8SAI	1-oleoyl-2-hydroxy-sn-glycero-3-phospho-L-serine	8SAI-GPR34-1-oleoyl-2-hydroxy-sn-glycero-3-phospho-L-serine-Gi1/&β;1/&γ;2
4.00	Single	8X2K	5YM	8X2K-GPR3-5YM-chim(NtGi1-Gs)/&β;1/&γ;2
3.70	Single	8K4N	VF0	8K4N-GPR34-VF0-Gi1/&β;1/&γ;2
3.45	Single	8IZ4	Lysophosphatidylserine	8IZ4-GPR34-Lysophosphatidylserine-Gi1/&β;1/&γ;2
3.33	Single	8JLP	Ralmitaront	8JLP-TA1-Ralmitaront-Gs/&β;1/&γ;2
3.33	Single	8XBI	S3E-LysoPS	8XBI-GPR34-S3E-LysoPS
3.33	Consensus	s1p2_on	Orthosteric Ligand	7T6B-S1P₂-S1P-chim(NtGi1L-G13)/&β;1/&γ;2
3.23	Single	7T6B	S1P	7T6B-S1P₂-S1P-chim(NtGi1L-G13)/&β;1/&γ;2
3.23	Single	7XZ5	Lysophosphatidylcholine	7XZ5-GPR119-Lysophosphatidylcholine-Gs/&β;1/&γ;2
3.23	Single	8WRB	Lysophosphatidylserine	8WRB-GPR34-Lysophosphatidylserine-Gi1/&β;1/&γ;2
2.94	Single	6RZ8	ONO-2080365	6RZ8-CysLT₂-ONO-2080365
2.94	Single	8IZB	Lysophosphatidylserine	8IZB-GPR174-Lysophosphatidylserine-Gs/&β;1/&γ;2
2.94	Single	8XBH	S3E-LysoPS	8XBH-GPR34-S3E-LysoPS-Gi1/&β;1/&γ;2
2.56	Single	7XV3	Lysophosphatidylserine	7XV3-GPR174-Lysophosphatidylserine-chim(NtGi1-Gs)/&β;1/&γ;2

PDB Summary
PDB	5KW2
Class	A
SubFamily	Lipid
Type	Free fatty acid
SubType	FFA1 (GPR40)
Species	Homo sapiens
Ligand	-
Other Ligand(s)	PubChem 133053953
Protein Partners	-
PDB Resolution	2.76
Date	2018-05-02
D.O.I.	10.1038/s41467-017-01240-w

Net Summary
I_min	3.5
Number of Linked Nodes	227
Number of Links	248
Number of Hubs	31
Number of Links mediated by Hubs	126
Number of Communities	3
Number of Nodes involved in Communities	37
Number of Links involved in Communities	52

Path Summary
Number Of Nodes in MetaPath	79
Number Of Links MetaPath	78
Number of Shortest Paths	28314
Length Of Smallest Path	3
Average Path Length	11.5829
Length of Longest Path	26
Minimum Path Strength	1.415
Average Path Strength	5.70408
Maximum Path Strength	13.245
Minimum Path Correlation	0.7
Average Path Correlation	0.906027
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	4.7619
Average % Of Corr. Nodes	47.5399
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	48.6193
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process
Gene Ontology	Cellular Component
SCOP2	Domain Identifier
SCOP2	Family Identifier
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	6XQ
PDB Residues	W:W:?1
Environment Details	Open EMBL-EBI Page
Code	6XQ
Name	(3~{S})-3-cyclopropyl-3-[2-[1-[2-[2,2-dimethylpropyl-(6-methylpyridin-2-yl)carbamoyl]-5-methoxy-phenyl]piperidin-4-yl]-1-benzofuran-6-yl]propanoic acid
Synonyms
Identifier	(3~{S})-3-cyclopropyl-3-[2-[1-[2-[2,2-dimethylpropyl-(6-methylpyridin-2-yl)carbamoyl]-5-methoxy-phenyl]piperidin-4-yl]-1-benzofuran-6-yl]propanoic acid
Formula	C38 H45 N3 O5
Molecular Weight	623.781
SMILES	Cc1cccc(n1)N(CC(C)(C)C)C(=O)c2ccc(cc2N3CCC(CC3)c4cc5ccc(cc5o4)[C@@H](CC(=O)O)C6CC6)OC
PubChem	133053953
Formal Charge	0
Total Atoms	91
Total Chiral Atoms	1
Total Bonds	96
Total Aromatic Bonds	22


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	O14842
Sequence	>5KW2_Chain_R L P P Q L S F G L Y V A A F A L G F P L N V L A I R G A T A T P S A V Y A L N L G C S D L L L T V S L P L K A V E A L A S G A W P L P A S L C P V F A V A H F A P L Y A G G G F L A A L S A A R Y L G A A F P L G Y Q A F R R P C Y S W G V C A A I W A L V L C H L G L V F G L E A P V C L E A W D P A S A G P A R F S L S L L L F F L P L A I T A F C F V G C L R A L A R S L T H R R K L R A A W V A G G A L L T L L L C V G P Y N A S N V A S F L Y P N L G G S W R K L G L I T G A W S V V L N P L V T G Y Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	4PHU	A	Lipid	Free fatty acid	FFA1 (GPR40)	Homo sapiens	-	Fasiglifam	-	2.33	2014-07-16	10.1038/nature13494
	5TZR	A	Lipid	Free fatty acid	FFA1 (GPR40)	Homo sapiens	-	MK8666	-	2.2	2017-06-07	10.1038/nsmb.3417
	5TZY	A	Lipid	Free fatty acid	FFA1 (GPR40)	Homo sapiens	-	MK8666; PubChem 127053597	-	3.22	2017-06-07	10.1038/nsmb.3417
	8EIT	A	Lipid	Free fatty acid	FFA1 (GPR40)	Homo sapiens	Doconexent	-	chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2	2.8	2023-05-24	10.1073/pnas.2219569120
	8EJC	A	Lipid	Free fatty acid	FFA1 (GPR40)	Homo sapiens	TAK-875	-	chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2	3	2023-05-24	10.1073/pnas.2219569120
	8EJK	A	Lipid	Free fatty acid	FFA1 (GPR40)	Homo sapiens	TAK-875	-	chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2	3.4	2023-05-24	10.1073/pnas.2219569120

You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download 5KW2.zip

You can click to copy the link of this page to easily come back here later

or use this QR code to link and share this page.

You can also read or download a guide explaining the meaning of all files and numerical data.